Patent EA-000166-B1 (EA)
Title: Biologically active ureido derivatives useful in the treatment of multiple sclerosis
Inventor: ALZANI RACHELE
IPC: A61P37/00
Filed: 1997-01-24
Abstract: 1. Use of a compound which is a ureido derivative of formula (I)   wherein each of m and n, which are the same, is an integer of 1 to 3; and each of the R groups, which are the same, is a naphthyl group substituted by 1 to 3 sulfonic acid groups, or a pharmaceutically acceptable salt thereof; in the manufacture of a medicament for use in the treatment of multiple sclerosis. 2. Use as claimed in Claim 1 wherein, in formula (I), m and n are each 2. 3. Use as claimed in Claim 1 wherein the compound is selected from: 7,7'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylimino (N-methyl-4,2-pyrrole) carbonylimino}] bis (3,5-naphthalene-disulfonic acid); 7,7'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylimino (N-methyl-4,2-pyrrole) carbonylimino}] bis (3,6-naphthalene-disulfonic acid); 7.7'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylimino (N-methyl-4,2-pyrrole) carbonylimino}] bis (l,3,5-naphthalene-trisulfonic acid); 8,8'- [carbonyl-bis {imino-N-niethyl-4,2-pyrrolecarbonylimino ^ (N-methyl-4,2-pyrrole)carbonylimino}] bis(1,3,6-naphthalene- trisulfonic acid); 7.7'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylimino (N-methyl-4,2-pyrrole) carbonylimino}] bis (1,3-naphthalene-disulfonic acid); 7,7'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylimino (N-roethyl-4,2-pyrrole) carbonylimino }] bis(2, 4-naphthalene-disulfonic acid); 8, 8' - [carbonyl-bis {imino-N-roethyl-4,2-pyrrolecarbonylimino (N-methyl-4,2-pyrrole) carbonylimino}] bis (2, 4-naphthalene-disulfonic acid), 8,8'- [carbonyl -bis {imino-N-methyl-4,2-pyrrolecarbonyliraino (N-roethyl-4,2-pyrrole) carbonylimino)}] bis(l, 3,5-naphthalene-trisulfonic acid); 8,8'- [carbonyl -bis {imino-N-methyl -4,2 -pyrrolecarbonylimino (N-roethyl-4,2-pyrrole) carbonylimino}]) bis (5-naphthalene-sulfohic acid), 8,8'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylimino (N-roethyl-4,2-pyrrole) carbonylimino}] bis (1,3-naphthalene-disulfonic acid), 8,8'- [carbonyl-bis (imino-N-methyl-4,2-pyrrolecarbonylimino (N-roethyl -4,2-pyrrole) carbonylimino}] bis (3,5-naphthalene-disulfonic acid); 8,8'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylimino (N-roethyl-4,2-pyrrole) carbonylimino}] bis (1,5-naphthalene-disulfonic acid); 8,8'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylimino (N-inethyl-4,2-pyrrole) carbonylimino}] bis (3-naphthalene sulfonic acid); 8,8'- [carbonyl-bis {imino-N-metbyl-4.2-pyrrolecarbonylimino (N-methyl -4,2 -pyrrole) carbonylimino}] bis (1 -naphthalene-sulfonic, acid); 2,2'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylimino (N-methyl-4,2-pyrrole) carbonylimino}] bis (1,5-naphthalene-disulfonic acid); 7,7'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylimino (N-methyl-4,2-pyrrole) carbonylimino}] bis (1,6-naphthalene-disulfonic acid); 7,7'- [carbonyl-bis {imino-N-methyl -4,2-pyrrolecarbonylimino (N-methyl-4,2-pyrrole) carbonylimino }] bis (2, 6-naphthalene-disulfonic acid); 7,7- [carbonyl-bis {imino-M-me thyl -4,2 -pyrrolecarbonyl imino (N-methyl-4,2-pyrrole) carbonylimino}] bis(l,5-naphthalene-disulfonic acid);, 7,7'- [carbonyl-bis {imino-N-methyl-4,'2-pyrrolecarbonylimino (N-methyl-4,2-pyrrole) carbonylimino}] bis (2,5-naphthalene-disulfonic acid); 7,7'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylimino (N-methyl-4,2-pyrrole^carbonylimino}] bis (2,3-naphthalene-disulfonic acid), ' 8,8'- [carbonyl-bis (imino-N-methyl-4,2-pyrrolecarbonylimino (N-methyl-4,2-pyrrole) carbonylimino}] bis (1,6-naphthalene-disulfonic acid); 8,8'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylimino (N-methyl-4,2-pyrrole) carbonylimino}] bis (2,6-naphthalene-disulfonic acid); 8,8'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylimino (N-methyl-4,2-pyrrole) carbonylimino}] bis (2,5-naphthalene-disulfonic acid); 8,8'- [carbonyl -bis {imino-N-methyl -4,2 -pyrrolecarbonylimino (N-methyl-4,2-pyrrole) carbonylimino}] bis (3,6-naphthalene-disulfonic acid); 8,8'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylimino (N-tnethyl-4,2-pyrrole) carbonylimino}] bis (2,3,5-naphthalen trisulfonic acid);' 8,8'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylinu.no (N-methyl -4,2-pyrrole) carbonylimino}] bis (1,4,6-naphthalene-trisulfonic acid); 8,8'- [carbonyl-bis {imino-N-methy 1-4,2-pyrrolecarbonylinu.no (N-methyl-4,2-pyrrole) carbonylimino}] bis 2,4,6-naphthalene-trisulfonic acid); 7,7'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonyl inono (N-methyl-4,2-pyrrole) carbonylimino}] bis (l-naphthalene sulfonic acid); 7,7'- [carbonyl -bis {iniino-N-methyl -4,2 -pyrrolecarbonylimino (N-methyl-4.2-pyrrole) carbonylimino}] bis (2-naphthalene sulfonic acid); 7,7'- [carbonyl-bis {imino-N-methyl-4,2-pyrroleearbonylimino (N-methyl-4, 2-pyrrole) carbonylimino}] bis (3-naphthalene sulfonic acid); 7,7'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylimino (N-methyl-4,2-pyrrole) carbonylimino}] bis (4 -naphthalene sulfonic acid); 7,7'- [carbonyl-bis {imino-N-methyl-4,2 -pyrrolecarbonylimino (N-methyl-4,2-pyrrole) carbonylimino})bis (1,4,6-naphthalene-trisulfonic acid); 7,7'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylimino (N-methyl-4,2-pyrrole)carbonylimino}] bis (l,3,6-naphthalene-trisulfonic acid); 7,7'-[carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylimino}] bis (1,3-naphthalene disulfonic acid); 7,7'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylimino (N-methyl-4,2-pyrrolecarbonylimino [N-methyl-4,2-pyrrole] carbonylimino}] bis (1.3-naphthalene disulfonic acid); 7,7'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonylimino (N-methyl-4, 2-pyrrole) carbonylimino}] bis (2,4,6-naphthalene-trisulfonic acid); 7,7'- [carbonyl-bis {imino-N-methyl-4,2-pyrrolecarbonyliinino (N-methyl -4.2 -pyrrole) carbonylimino}] bis (2,3,5 -naphthalene-trisulfonic acid; and the pharmaceutically acceptable salts thereof. 4. Use as claimed in Claim 1, "wherein the compound is the sodium or potassium salt of a ureido derivative of formula (I). 5. Use as claimed in Claim 1, wherein the medicament is for treating relapse and/or progression of multiple sclerosis, or for ameliorating the clinical symptoms of a patient suffering from multiple sclerosis.