Patent SG-11201901528R-A (SG)
Title: Proteolytically cleavable chimeric polypeptides and methods of use thereof
Inventor: LIM WENDELL A
IPC: C07K19/00
Filed: 2017-08-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 March 2018 (01.03.2018) W I PO I PCT olimion °nolo III 111111111o1110 Ho Imo oimIE (10) International Publication Number WO 2018/039247 Al (51) International Patent Classification: C07K 16/30 (2006.01) C07K 19/00 (2006.01) (21) International Application Number: PCT/US2017/048040 (22) International Filing Date: 22 August 2017 (22.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/378,614 23 August 2016 (23.08.2016) US (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor, Oakland, California 94607 (US). (72) Inventors: LIM, Wendell A.; 149 Collins Street, San Fran- cisco, California 94118 (US). ROYBAL, Kole T.; 600 16th Street, San Francisco, California 94158 (US). WILLIAMS, Jasper Z.; 600 16th Street, San Francisco, California 94158 (US). (74) Agent: GUEDELHOEFER, Otto C.; 201 Redwood Shores Parkway, Suite 200, Redwood City, California 94065 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) 1-1 N 71- (54) Title: PROTEOLYTICALLY CLEAVABLE CHIMERIC POLYPEPTIDES AND METHODS OF USE THEREOF cn (57) : The instant disclosure provides chimeric polypeptides which modulate various cellular processes following a cleavage f .r1 event induced upon binding of a specific binding member of the polypeptide with its binding partner. Methods of using chimeric polypeptides to modulate cellular functions, including e.g., induction of gene expression, are also provided. Nucleic acids encoding the subject chimeric polypeptides and associated expression cassettes and vectors as well as cells that contain such nucleic acids and/or 1-1 © expression cassettes and vectors are provided. Also provided, are methods of treating a subject using the described components and f'1 methods as well as kits for practicing the subject methods.