baber/WOPTO huggingface dataset:
Patent AU-628895-B2 (AU)
Title: Cloning and expression of a protein which modulates cellular response to type i interferon
Inventor: REVEL MICHEL
IPC: C07K14/715
Filed: 1989-11-14
Granted: 1992-09-24
Abstract: The gene encoding a protein (L7) which appears to be a part of the human Type I interferon receptor has been cloned and expressed by recombinant DNA techniques. The protein impacts a non-species specific enhanced responsiveness to Type I interferon to transformed cells. The protein is found on the surface of Daudi cells and has structural features characteristic of receptor proteins.
Patent AU-554303-B2 (AU)
Title: 6-fluoro-4-chromanone from 6-fluoro-4-ureidochroman-4- carboxylic acid
Inventor: MOORE BERNARD SHIELDS
IPC: C07D311/22
Filed: 1985-09-25
Granted: 1986-08-14
Abstract: 6-Fluoro-4-chromanone can be regenerated from (R)-6-fluoro-4-ureidochroman-4-carboxylic acid, or from mixtures of (R)-6-fluoro-4-ureidochroman-4-carboxylic acid and its racemic modification, by oxidation with a permanganate, especially potassium permanganate. 6-Fluoro-4-chromanone is a chemical intermediate useful for preparing sorbinil, an aldose reductase inhibitor which can be used in clinical medicine for the control of the chronic complications of diabetes. (R)-6-Fluoro-4-ureidochroman-4-carboxylic acid and its racemic modification are by-products from the production of sorbinil from 6-fluoro-4-chromanone.
Patent AU-584157-B2 (AU)
Title: Urea derivatives
Inventor: LASSEN NIELS
IPC: C07C275/24
Filed: 1986-01-09
Granted: 1989-05-18
Abstract: Novel aminoalkyl substituted urea derivatives of the formula: 
<CHEM>
 wherein X and Y are the same or different and are selected from the group consisting of a phenyl group, each of said phenyl groups being optionally substituted with one or two groups selected from halogen, CF3, OH, or alkoxy (1-4 C-atoms); and R<1> and R<2> are the same or different, and are each selected from the group consisting of lower alkyk groups having from one to four carbon atoms inclusive, or they form together with the nitrogen atom a saturated five- or six-membered heterocyclic ring; R<3> anmd R<4> are each selected from hydrogen, lower alkyl or alkenyl groups with from 1-6 carbon atoms inclusive, cyclopentyl or cyclohexyl; and n is 0 or 1, as well as pharmaceutically acceptable acid addition salts thereof,
 and enantiomers,
 are described as having pronounced anti-neoplastic activity against various tumors.
 A method for the preparation of the compounds of Formula I is described, as well as pharmaceutical compositions containing a compound of Formula I as an active ingredient.
Patent AU-630932-B2 (AU)
Title: Generation of specific probes for target nucleotide sequences
IPC: C12Q1/689
Filed: 1990-04-18
Granted: 1992-11-12
Abstract: A method for generating DNA probes specific for an organism and capable of distinguishing in a non-empirical manner between species. The method comprises amplifying, using a pair of oligonucleotide primers, a variable region of the genome of a number of phylogenetically related organisms to, or of a number of organisms suspected of being present in a given sample containing, said organism to be identified and having said variable region in its genome, at least one of said primers corresponding to a DNA sequence known or suspected of being conserved in said organisms, determining the sequence of the amplified region, selecting said sequence or a portion thereof to generate said probe specific for said organism to be identified by comparison with said other amplified regions and defining the hybridization conditions required to obtain a specific signal based on the precise nucleotide sequence of the selected probe. Specific probes are disclosed for a variety of species including Aeromonas hydrophila, Aeromonas salmonicida, Clostridium difficile, Mycobacterium bovis, Mycobacterium tuberculosis and Salmonella typhimurium.
Patent AU-709127-B2 (AU)
Title: 6-carboxamido dihydropyran derivatives
Inventor: CHERRY PETER
IPC: A61K31/40
Filed: 1996-05-13
Granted: 1999-08-19
Abstract: PCT No. PCT/AU96/00289 Sec. 371 Date Jan. 12, 1998 Sec. 102(e) Date Jan. 12, 1998 PCT Filed May 13, 1996 PCT Pub. No. WO96/36628 PCT Pub. Date Nov. 21, 1996Compounds of formula (I), wherein R1 represents OR5, SR5, NR5R6, N(OR5)R6 or N(NR5R6)R6; X represents OH, N3, NR3R4 or NR4CO2R15; Y represents H or NHR2; R2 represents a group SO2R7 or COR7; R3 represents H, C1-6alkyl or C(=NR8)NR9R10; R4 represents H or C1-6alkyl; R5 represents H, C1-20alkyl, C3-8cycloalkyl, C2-20alkenyl, C2-20alkynyl, CHR11COR12 or C1-20alkyl substituted by one or more groups selected from NR13R14, NR13COR14, CO2R13, OR13, C3-8cycloalkyl and optionally substituted aryl; each R6 independently represents H, C1-6alkyl, C3-8cycloalkyl, C2-6alkenyl, C2-20alkynyl, aryl or C1-4alkyl substituted by one or more groups selected from NR13R14, COR13, C3-8cycloalkyl, CN, N3, OR13 and optionally substituted aryl; or R5 and R6 together form a C2-6 hydrocarbon chain which may optionally contain a group NR13 which chain is optionally substituted by 1, 2, 3 or 4 groups selected from oxo and C1-6alkyl groups which groups may optionally be substituted by hydroxy or optionally substituted aryl; R7 represents C1-6alkyl optionally substituted by one or more halogen atoms, C3-8cycloalkyl or optionally substituted aryl; R8, R9 and R10 each independently represent H, C1-6alkyl, amino, hydroxy, cyano or nitro; R11 represents the side chain of a D- or L-amino acid; R12 represents NR13R14, OR13 or R13; each R13 and each R14 independently represents H, C1-6alkyl or optionally substituted arylC1-4alkyl; R15 represents C1-6alkyl; and their pharmaceutically acceptable derivatives are neuraminidase inhibitors useful in the treatment of viral infections.
Patent AU-682840-B2 (AU)
Title: Slip-on spectacle lenses
Inventor: GANDL-SCHILLER ELISABETH
IPC: G02C9/00
Filed: 1993-12-10
Granted: 1997-10-23
Abstract: PCT No. PCT/EP93/03496 Sec. 371 Date Oct. 10, 1995 Sec. 102(e) Date Oct. 10, 1995 PCT Filed Dec. 10, 1993 PCT Pub. No. WO94/14101 PCT Pub. Date Jun. 23, 1994A clip-on spectacle accessory for rimless, clip-on lenses has clasps that are directly secured to the top edge of each lens. Each clasp forms part of a holder structure for an elastic bridge that connects the clip-on lenses and provides elastic gripping action to hold the accessory to a pair of spectacles. A lower clasp is provided on each clip-on lens so that they are prevented from spreading away from the spectacles.
Patent AU-599028-B2 (AU)
Title: 99mTc(III) myocardial imaging agents which are non-reducable in vivo
Inventor: DEUTSCH EDWARD A
IPC: C07F13/00
Filed: 1986-05-09
Granted: 1990-07-12
Abstract: A cationic <99m>Tc<III> myocardial imaging agent is disclosed which has a relatively negative redox potential. This prevents in vivo reduction of the Tc(III) to Tc(II). The redox potential of the Tc(III) is controlled by complexing the Tc with both hard and soft atoms. Preferably four of the atoms complexed to the Tc(III) are hard atoms such as nitrogen or oxygen and the remaining two are soft atoms such as phosphorous or arsenic. These imaging agents are particularly useful in imaging the human heart.
Patent AU-716156-B2 (AU)
Title: Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
Inventor: KORNBERG BRIAN EDWARD
IPC: A61P25/08
Filed: 1996-05-13
Granted: 2000-02-17
Abstract: A novel series of substituted quinoxaline 2,3-diones useful as neuroprotective agents are taught. Novel intermediates, processes of preparation, and pharmaceutical compositions containing the compounds are also taught. The compounds are glutamate antagonists and are useful in the treatment of stroke, cerebral ischemia, or cerebral infarction resulting from thromboembolic or hemorrhagic stroke, cerebral vasospasms, hypoglycemia, cardiac arrest, status epilepticus, perinatal asphyxia, anoxia, Alzheimer's, Parkinson's, and Huntington's diseases.
Patent AU-779761-B2 (AU)
Title: Medicament for treatment of neuropathies
Inventor: LAREIDA JURG
IPC: A61P1/00
Filed: 2000-07-27
Granted: 2005-02-10
Abstract: Compounds of formula (I) in which R<SUP>1</SUP>=C<SUB>1-6 </SUB>alkyl, optionally halosubstituted; R<SUP>2</SUP>=H, C<SUB>1-4 </SUB>alkyl, optionally halosubstituted or replaced by halogen; R<SUP>3</SUP>=C<SUB>2-4 </SUB>alkyl, optionally halosubstituted; R<SUP>4</SUP>=SO<SUB>2</SUB>NR<SUP>5</SUP>R<SUP>6</SUP>, CO<SUB>2</SUB>R<SUP>7 </SUP>or halogen, C<SUB>2-4 </SUB>alkenyl; optionally substituted with NR<SUP>5</SUP>R<SUP>6</SUP>, SONR<SUP>5</SUP>R<SUP>6</SUP>, CONR<SUP>5</SUP>R<SUP>6</SUP>, CO<SUP>2</SUP>R<SUP>7 </SUP>or halogen, C<SUB>2-4 </SUB>alkanoyl, optionally substituted with NR<SUP>5</SUP>R<SUP>6</SUP>, SONR<SUP>5</SUP>R<SUP>6</SUP>, CONR<SUP>5</SUP>R<SUP>6</SUP>, CO<SUB>2</SUB>R<SUP>7 </SUP>or halogen; R<SUP>5 </SUP>and R<SUP>6</SUP>=independently H or C<SUP>1-4 </SUP>alkyl, or, together with the N atom to which they are attached, a pyrrolidino, piperidino, morpholino, 4-(NR<SUP>8</SUP>)-1-piperazinyl or 1-imidazolyl ring optionally substituted with one or two C<SUB>1-4 </SUB>alkyl groups; R<SUP>7</SUP>=H, C<SUP>1-4 </SUP>alkyl, optionally fluorosubstituted, and R<SUP>8</SUP>=H,C<SUP>1-3 </SUP>alkyl or hydroxyalkyl with 1-4 C atoms, or the pharmaceutically acceptable salts thereof are useful for the chemotherapeutic treatment of neuropathies.
Patent AU-765284-B2 (AU)
Title: Use of bisphosphonic acid derivatives for preparing a medicine for treating lameness
Inventor: MESNIL PHILIPPE DU
IPC: A61P19/02
Filed: 1999-10-01
Granted: 2003-09-11
Abstract: The invention relates to a process for treating lameness with an osseous, articular or osteoarticular component, comprising the administration, to a human or to an animal not suffering from arthritis or from fractures, of an effective amount of a bisphosphonic acid derivative of formula: in which: R1 represents a hydrogen atom, a halogen atom, a hydroxyl, an amino, a mono(C1-C4)alkylamino or a di(C1-C4) alkylamino; R2 represents a halogen atom, a linear alkyl comprising from 1 to 5 carbon atoms which is unsubstituted or substituted with a group chosen from a chlorine atom, a hydroxyl, an amino, a mono(C1-C4)alkylamino or a di(C1-C4)alkylamino; a (C3-C7) cycloalkylamino, or R2 represents a phenoxy, a phenyl, a thiol, a phenylthio, a chlorophenylthio, a pyridyl, a pyridyl-methyl, a 1-pyridyl-1-hydroxymethyl, an imidazolyl-methyl or a 4-thiomorpholinyl, of one of its pharmaceutically acceptable salts or of one of its hydrates.
Patent AU-516431-B2 (AU)
Title: Specific binding assay
Inventor: FEINGERS J
IPC: G01N33/78
Filed: 1980-05-27
Granted: 1981-06-04
Abstract: A specific binding assay method, and a test device and test kit for use therein, for determining a liqand, such as an antigen or antibody, in, or the ligand binding capacity of, a liquid medium, particularly a body fluid such as serum, wherein the unknown ligand competes with a labeled component, such as a radiolabeled form of the ligand or of a binding analog of the ligand, for binding with a binding partner, and wherein separation of the resulting bound-species and free-species of the labeled component is accomplished by allowing the liquid reaction mixture to be drawn by capillary action into a column comprising a bed of an adsorbent material selective for one of the two species. The improvement comprises using a column containing at least one additional bed of capillarily absorbent material disposed above said adsorbent bed and which is substantially nonadsorbent relative to the one of said two species which said adsorbent bed selectively binds. The use of specific types of capillarily absorbent beds in addition to the selectively adsorbent bed to form multilayer columns overcomes several unforeseen problems encountered in using the previously known column chromatography method for certain assay applications.
Patent AU-699782-B2 (AU)
Title: Heating sheet bundle for regenerative heat exchangers
Inventor: KOSTER GERD
IPC: F28D19/04
Filed: 1996-07-29
Granted: 1998-12-17
Abstract: The hot plate packet comprises a number of adjacent profile plates held together but leaving flow channels between them. On at least two opposing packet sides (18, 19) the two outer profile plates (14, 15) are formed as sandwich-type shape-stable profile plate pairs. One profile plate of the pair is undulated and the other is corrugated. The profile plates are joined to one another by welding points (16). The vertical outer rail (20) of the profile plates are connected to horizontal rails (21) on the packet upper and lower sides. The face surfaces of the horizontal rails are located at the same height as the face surfaces of the radial walls of the cells of the hot surface carrier (4).
Patent AU-649416-B2 (AU)
Title: Glycosaminoglycan-modified protein
Inventor: SAKURAI KATSUKIYO
IPC: A61K47/48
Filed: 1990-10-10
Granted: 1994-05-26
Abstract: A glycosaminoglycan-modified protein wherein an amino group of a protein is bound to an aldehyde group, which has been formed by reducing and partially oxidizing the reducing terminal sugar moiety of a glycosaminoglycan, which has a high stability in vivo and can retain physiological activity of the protein for a prolonged period of time.
Patent AU-732161-B2 (AU)
Title: High power laser devices
Inventor: MOORADIAN ARAM
IPC: H01S5/14
Filed: 1998-03-19
Granted: 2001-04-12
Abstract: In an apparatus and method for generating high power laser radiation, the geometry of the resonant laser cavity defines a fundamental spatial or transverse cavity mode. A gain medium is disposed within the resonant cavity and an energy source energizes the gain medium within a first volume. This causes spontaneous and stimulated energy emission to propagate in the gain medium in a direction transverse to the fundamental cavity mode. The transverse emission in turn optically pumps a second volume of the gain medium about the first volume. When the intensity of the transverse emission is sufficiently high, inversion and gain are produced in the second volume. By optimizing the geometry of the cavity such that the fundamental cavity mode is coupled to both the first and the second volumes encompassing the first pumped volume, the transversely-directed energy of the first volume which would otherwise be wasted is instead captured by the fundamental beam, improving the overall power efficiently of the laser. When configured in an appropriate cavity, the high-power laser of the present invention is especially amenable to frequency conversion of the output beam, as it provides beam intensities suitable for efficient nonlinear frequency conversion.
Patent AU-540887-B2 (AU)
Title: Impact irrigator
Inventor: DRECHSEL ARNO
IPC: B05B3/16
Filed: 1981-05-12
Granted: 1984-12-06
Abstract: An improved impact irrigator comprising a rapid return device constituted by a deflector disposed at the end of a rocker lever and arranged to be immersed into the jet when in its operating position; the rocking movements of the lever are induced by a linkage controlled by an appendix which, at the end of the outward and return rotations of the irrigator, interferes with two fixed stops; when the rocker lever is in its rest position with the deflector outside the jet, the configuration of the linkage is such as to keep the lever locked in position, so making it insensitive to external stresses; the connection between the linkage and lever is made with a certain slack which enables the lever, when outside its rest position, to rock further through a short distance without changing the configuration of the linkage.
Patent AU-723518-B2 (AU)
Title: Modular filtration systems and methods
Inventor: CHANCELLOR DENNIS
IPC: B01D63/14
Filed: 1998-04-13
Granted: 2000-08-31
Abstract: A filtration system includes production modules (305) which are mechanically coupled in series, and which contain filters that are fluidly coupled in parallel. Among the many different possibilities contemplated, each production module may advantageously contain not only a filter (314), but also flowpaths for feed fluid (334a), waste fluid (334b), and product fluid (334c) so that a series of coupled modules can be installed, accessed, and removed as single unit. It is further contemplated that coupled modules may be deployed in space efficient manner, such as by insertion into a deep or shall well, a tower, along the ground, into the side of a hill or mountain, or even under a road or parking lot. It is still further contemplated that adjacent production modules may be designed to mate with one another using a slip fit joint, and that the production modules may be maintained in mating relationship through connections to supporting cables or rods.
Patent AU-652744-B2 (AU)
Title: Method and compositions for inhibiting angiogenesis
Inventor: MOSES MARSHA A
IPC: A61K39/395
Filed: 1991-01-25
Granted: 1994-09-08
Abstract: Pharmaceutical compositions for delivering an effective dose of an angiogenesis inhibitor consisting of a specific inhibitor of collagenase, for inhibition of blood vessel ingrowth and tube formation in vivo and capillary endothelial cell proliferation and migration in vitro, which is non-cytotoxic to normal cells. The compositions are delivered topically or locally using implants or injection. Examples of specific collagenase inhibitors include purified cartilage-derived inhibitor, collagenase binding peptides and antibodies which block the active site or metal binding regions of collagenase, and compounds which inhibit enzymes activating collagenase, such as plasmin inhibitor.
Patent AU-711907-B2 (AU)
Title: Mercaptoalkylpeptidyl compounds having an imidazole substituent and their use as inhibitors of matrix metalloproteinases (MMP) and/or tumor necrosis factor (TNF)
Inventor: BAXTER ANDREW DOUGLAS
IPC: A61K31/4178
Filed: 1996-11-22
Granted: 1999-10-21
Abstract: Peptidyl compounds having an imidazole substituent have therapeutic utility via their inhibitory effect on metalloproteinases and tumour necrosis factor.
Patent AU-653350-B2 (AU)
Title: Aqueous dispersions of sparingly soluble UV absorbers
Inventor: JOLLENBECK MARTIN
IPC: C09B67/46
Filed: 1991-07-22
Granted: 1994-09-29
Abstract: Aqueous stable dispersions of UV-absorbent s-triazine compounds containing   (a) 5 to 50 percent by weight of an n-triazine compound of the formula <IMAGE>     (b) 0 to 18 percent by weight of an anionic compound, and (c) 0 to 18 percent by weight of a nonionic compound, with the proviso that at least one of components (b) and (c) must be present.   These dispersions are excellent for improving the light fastness of dyeings on synthetic fibres, in particular polyester fibres or acid-modified polyester fibres.
Patent AU-678643-B2 (AU)
Title: Process for manufacturing caprolactam
Inventor: FUCHS EBERHARD
IPC: C07D201/08
Filed: 1994-11-15
Granted: 1997-06-05
Abstract: PCT No. PCT/EP94/03782 Sec. 371 Date May 16, 1996 Sec. 102(e) Date May 16, 1996 PCT Filed Nov. 15, 1994 PCT Pub. No. WO95/14665 PCT Pub. Date Jun. 1, 1995Cyclic lactams are prepared by reacting amino carbonitriles with water in liquid phase in a fixed bed reactor in the presence of heterogeneous catalysts which have no soluble constituents under the reaction conditions.
Patent AU-648114-B2 (AU)
Title: Process for preparing albuterol, acetal, hemi-acetal, and hydrates of arylglyoxal intermediates thereof
Inventor: TANN CHOU-HONG
IPC: C07C69/88
Filed: 1991-09-06
Granted: 1994-04-14
Abstract: PCT No. PCT/US91/06248 Sec. 371 Date Mar. 1, 1993 Sec. 102(e) Date Mar. 1, 1993 PCT Filed Sep. 6, 1991 PCT Pub. No. WO92/04314 PCT Pub. Date Mar. 19, 1992.The preparation of arylethanolamines, and in particular albuterol (salbutamol), together with their novel boron, acetal and hemi-acetal intermediates is described.
Patent AU-733739-B2 (AU)
Title: Flame retardant resin composition
Inventor: IMAHASHI TAKESHI
IPC: C08K3/22
Filed: 1998-09-29
Granted: 2001-05-24
Abstract: A flame retardant resin composition comprising (A) 100 parts by weight of a synthetic resin, (B) 20 to 150 parts by weight of magnesium hydroxide particles and (C) 20 to 150 parts by weight of aluminum hydroxide particles, wherein the magnesium hydroxide particles and the aluminum hydroxide particles satisfy the following conditions (i) to (v): (i) the average secondary particle diameter measured by a microtrack method is 0.4 to 4 pm; (ii) the specific surface measured by a BET method is 1 to 15 m<2>/g; (iii) the total content of an iron compound and a manganese compound is 200 ppm or less in terms of metals (Fe + Mn); (iv) the ratio of the specific surface measured by the BET method to the specific surface measured by a Blaine method is 1 to 4; and (v) the content of a water-soluble sodium salt is 500 ppm or less in terms of metal sodium. The present invention provides a halogen-free flame retardant resin composition and a molded article therefrom which composition and article have excellent thermal stability, acid resistance, water-resistant insulating properties, mechanical strength and surface appearance and are economically advantageous.
Patent AU-547621-B2 (AU)
Title: Sign construction
Inventor: DOBSON CHARLES EDWARD
IPC: G09F7/08
Filed: 1982-10-20
Granted: 1985-10-24
Abstract: A sign comprises sign plates (18,18 min ,25) arranged edge-to-edge between a pair of mounting bars (32) of L-shape, having a rear limb (29) for mounting to a supporting surface and a side limb (31) which conceals the ends of the plates. At least some of the plates (18,18 min ) have rearwardly directed limbs (20) which are a push fit on forwardly projecting elements (14) carried by base elements (10) slidably engaged in restricted mouth channels (33) formed on the rear limbs (29) of the mounting bars. The top and bottom plates (18 min ) have extensions (54) which conceal the mountings, and end caps (58) plug into box sections (50) on the side limbs (31) of the mounting bars to conceal the ends of those limbs (31) and the ends of the plate extensions (54).
Patent AU-648855-B2 (AU)
Title: Antiherpes compositions and method of use
Inventor: DEZIEL ROBERT
IPC: A61P31/22
Filed: 1991-12-30
Granted: 1994-05-05
Abstract: Disclosed herein is a combination of an antiviral nucleoside analog and a ribonucleotide reductase inhibiting peptide derivative. The combination is useful for combatting herpes infections.
Patent DE-1901509-B2 (DE)
Title: Bag for packing impact sensitive objects - has impact and pressure resisting insert from cellular material
IPC: B65D81/03
Filed: 1969-01-14
Abstract: Bag for packing objects sensitive to pressure or impact including an insert from sheet of low cost cellular sulphate material provided on one of its sides with large parallel ribs. The rubber side of the cellular sheet which is covered by stron paper forms the inside surface of the bag. The open end of the bag includes on its outside past the edge of cellular insert projecting part with folding marking on its surface to enable easy closing of the bag.
Patent DE-1917549-B2 (DE)
Title: Mechanism for picking up cohering bulk material - has suction duct orifice with pointed rotating auger type worm screw
IPC: B65G53/42
Filed: 1969-04-01
Abstract: The mechanism for loosening and removing bulk material consisting of cohering particles, such as copra, comprises a suction duct (4) at the orifice (10) of which there is a rotatable cutter in the form of an open worm screw (6). The duct can be moved about horizontal and vertical axes. The worm screw terminates in a point (9) whose centre line extends from the duct. It consists of a number of strips which, starting from the pointed end, are bent to form the helical screw windings.
Patent DE-1959676-B2 (DE)
Title: Universal joint type support for die for - drawing tubes from out of centre blanks
IPC: B21C3/14
Filed: 1969-11-28
Abstract: Mounting of drawing die for tube drawing for the drawing of tube blanks with non-uniform wall thickness, in a ball and socket type support fitted with guides for the tubes both in front of and behind the die, which has a bell mouth entry hole, and is self-adjusting in its angular position depending on the degree of deflection caused by the drawing forces as a result of the uneven wall thickness of the tube blank.