baber/WOPTO huggingface dataset:
Patent CR-20200100-A (CR)
Title: Bcma monoclonal antibody-drug conjugate
Inventor: HURT ELAINE M
IPC: C12N15/62
Filed: 2018-07-31
Abstract: The disclosure is directed to an antibody-drug conjugate (ADC) comprising a monoclonal antibody, or an antigen-binding fragment thereof, directed against B-cell maturation antigen (BCMA) conjugated to a cytotoxin. The disclosure also provides compositions comprising the antibody-drug conjugate and methods of killing multiple myeloma cells (including multiple myeloma stems cells) that express BCMA by contacting multiple myeloma cells with the ADC.
Patent EC-SP066484-A (EC)
Inventor: MANTLO NATHAN BRYAN
IPC: C07D403/04
Filed: 2006-04-05
Abstract: Compounds of formula I   
wherein n, m, p, q. Y, R 1  R 2 , R 3 , R 4 , R 6 , and R 6  are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating artherosclerosis and its sequelae.
Patent EG-22652-A (EG)
Title: A boiler constructed using a composite material
Inventor: LATINI LUCIO
IPC: F24H1/18
Filed: 2001-01-23
Granted: 2003-05-31
Abstract: The invention falls into the field of boilers made of polymeric matrix composite materials. The said boiler is constituted of two layers composed, in order from the inside to the outside, of a first layer (4) made of thermoplastic or elastomeric matrix material, and a second layer (5) composed of a plurality of filaments or strips of a synthetic material covered with resins which agglomerate by means of reticulation or fusion. The said first laser is built as a single body and is designed to come into direct contact with the water and the said second layer is also built as a single body and is designed to create structural resistance for the said boiler.
Patent FI-20011352-A (FI)
Inventor: NYMAN BROR
IPC: B01F7/24
Filed: 2001-06-25
Abstract: The invention relates to a method of clarifying and/or thickening a solution containing solids i.e. a slurry, and the apparatus for accomplishing this. Using the method and apparatus of the present invention, the flocculant to be fed into the clarification and thickening equipment is mixed evenly and with a small shear force into the slurry in the feedwell of the apparatus. The feedwell is equipped with a mixing device. The slurry is taken onwards from the feedwell evenly into the clarification tank inside the underflow layer, which enables the separation of a clear overflow solution.
Patent FI-20100182-A (FI)
Inventor: NYHOLM KUSTAA
IPC: A61B6/03
Filed: 2010-04-29
Abstract: The invention relates to a medical x-ray imaging apparatus which includes a support construction (1) supporting a substantially ring-shaped structure (2), an O-arm (2), which in turn supports imaging means (21, 22) and which O-arm (2) is arranged with an examination opening (4). The imaging means (21, 22) are arranged movable within the O-arm (2). The apparatus is arranged with a patient support handlebar (5), which is arranged to be positioned in at least a first and a second position of which in the first position the patient support handlebar (5) functions as a patient support handlebar and in the second position it has some other function.
Patent GB-1032795-A (GB)
Abstract: 1,032,795. Optical apparatus. WILD HEERBRUGG A.G. Feb. 8, 1963 [Feb. 9, 1962], No. 5309/63. Heading G2J [Also in Division G1] To facilitate reading of diametrically opposite points on a circular scale, the images of the two different graduations are seen together in an optical micrometer, the reading being in degrees, minutes, and seconds of arc.
Patent GB-1052105-A (GB)
IPC: B01J23/42
Abstract: 1,052,105. Oxidation catalysts. ENGELHARD INDUSTRIES Inc. Feb. 5, 1964 [Feb. 7, 1963], No. 5002/64. Heading B1E. An oxidation catalyst for exhaust gases with a superficial surface area of from 0.5 to 6 square metres/litre of said support and a density of from 0.45 to 1.05 gms/cc comprising an inert refractory unitary body having unobstructed openings therethrough and an active refractory metal oxide and at least 1.4 gms of platinum group metal/litre of support said active oxide in the form of film of total area of at least 50 square metres/gm of metal oxide.
Patent GB-1052934-A (GB)
IPC: G02F7/00
Abstract: 1,052,934. Electric selective signalling. STANDARD TELEPHONES & CABLES Ltd. Aug. 14, 1964 [Aug. 21, 1963]. No. 33101/63. Heading G4H. An analog to digital converter comprises a reflector or refractor, which is deflected in proportion to the analog and which is scanned by a beam of light. The resultant light beam falls on a coded scale, a photo-cell producing the corresponding electrical signal. A multiplex system is described. The analog signal may be speech. In a single channel system the analog signal feeds a mirror galvanometer 6, a piezo-electric crystal, or a refractive crystal. The scanning beam is derived from a revolving mirror system 4, which may be levitated, on to which is directed light from a D.C. lamp 1, laser, or lightemitting diode. The deflection of the beam perpendicular to the direction of scan is proportional to the amplitude of the analog signal. A coded scale 7, and photo-cell 9 give the digital signal in Gray code. The multiplex system uses several reflectors or refractors which are scanned in succession. The reflectors or refractors may be stacked in several rows, the revolving mirrors then being mounted at differing angles to give a raster scan.
Patent GB-1053095-A (GB)
IPC: B31B50/22
Abstract: 1,053,095. Scoring. TRI-WALL CONTAINERS Inc. Sept. 30, 1963, No. 38453/63. Heading B6J. [Also in Division B8] The longitudinal score lines 22, 23 defining the top and bottom flaps of a carton and running at right angles to the corrugations of the stock are relieved by squashed areas 34, 35. As shown in Fig. 5, a plain roller 44 cooperates with a roller 43 having a scoring flange 43a, a cylindrical portion 43b for creating the squashed area and a tapered part 43c to obviate an abrupt step between the squashed area and the adjacent surface of the stock.
Patent GB-1053515-A (GB)
IPC: F01K7/22
Abstract: 1,053,515. Forced flow steam boilers. SIEMENS-SCHUCKERTWERKE A.G. March 23, 1964 [March 23, 1963], No. 12262/64. Heading F4A. A steam boiler and turbine installation having a starting vessel 8, Fig. 1 (not shown), containing the last stage of a multistage feedwater preheating system, comprises a forced flow boiler 9, a superheater 10, a valve 16, high and low pressure turbines 12, 2, a reheater 13, feedwater control valve 21, measuring device 22 and the first two feedwater preheating stages 6, 7. The vessel 8 is connected to the superheater outlet via a HP reducing valve 17 and to the HP turbine outlet via conduit 14. Exhaust from the LP turbine passes to a condenser 1 from which condensate is pumped to a feedwater container 4. Steam condensed in the vessel 8 drains to stage 7 through valve 26 which opens when the level in vessel 8 reaches a predetermined level. However, during starting water drains directly to container 4 through valve 24 when the level reaches a second predetermined level greater than the first, except if the pressure in container 4 exceeds that in stage 8 or there is excess salt content in the water which then drains to waste through valve 25. For starting, valve 16 is closed and valve 17 opened, steam cooled by injecting water through pipe 18 then passes into the vessel 8. Dry steam is separated out and supplied to the reheater 13, water draining to container 4. The vessel 8 of cylindrical form has the valve 17 axially mounted at the top, Figs. 2-4, and conduit 14 entering radially permitting steam to flow over the plates 27, 28 to separate water. Feedwater is heated in a serpentine parallel pipe system 32 extending between inlet and outlet headers 31, 33. The vessel may be horizontal, Fig. 6, with the separating plates assembly mounted externally of the vessel. The steam may be directed tangentially into the assembly and the walls of the vessel may have cooling tubes adjacent this assembly.
Patent GB-1053597-A (GB)
IPC: C08F236/04
Abstract: 1,053,597. Butadiene - acrylonitrile - unsaturated acid terpolymer. UNITED STATES RUBBER CO. July 26, 1965 [Aug. 28, 1964], No. 31687/65. Heading C3P. A butadiene, an ethylenically unsaturated acid and an acrylonitrile are terpolymerized using an azo initiator in aqueous emulsion in the presence of a cationic emulsifier and a mercaptan modifier and short-stopping the terpolymerization at 40 to 80% conversion so as to form an emulsion of a liquid rubber, the terpolymerization being effected in the presence of from 0À001 to 0À1 parts per 100 monomers of a ferric salt dissolved in the emulsion. Specified monomers are butadiene, isoprene, 2-3-dimethyl butadiene and chlorobutadiene, acrylonitrile, methacrylonitrile, acrylic acid, methacrylic acid maleic acid, fumaric acid and ataconic acid. Preferred proportions are 60 to 95 parts butadiene, 1 to 39 parts acrylonitrile and 1-39 parts acid. The preferred emulsion is cetyldimethyl benzyl ammonium chloride, while n-dodecyl and tertiary dodecyl mercaptan are the preferred modifiers and azo-bis(isobutyronitrile) is the preferred initiator. Specified ferric salts are the nitrate, chloride, bromide, phosphite and (preferred) sulphate. Benzoquinone, carbamates and (preferred) hydroxyl ammonium sulphate are the short-stoppers.
Patent GB-1053894-A (GB)
IPC: F42B10/06
Abstract: 1,053,894. Fins. BOFORS A.B. Feb. 20, 1964 [Feb. 20, 1963], No. 7143/64. Heading F3A. Fins on a projectile are each fitted with at least one member which is adapted to bear against a projector without cutting or leaving deposits on the projector and to be separated from the fins on leaving the projector by the pressure of the combustion gases generated during firing. The member 6, made from nylon or polycarbonate, has a recess 7 with a bottom and curved end walls 8, 9, the width of the recess being the same as the thickness of the fins 4 which are provided with two rectangular slots 10, 11 having a part 12 between them. The depth of the recess 7 is slightly more than the depth of the slots 10, 11 and the member 6 is pressed over the part 12, there being a force fit between the curved ends 8, 9 and the plane rectangular ends 13, 14 of the part 12 so that a cavity is formed between the bottom of the recess 7 and the top of the part 12. On firing, explosive gases enter the cavity through the spaces between the wall parts 8, 9 and the end surfaces 13, 14 and when the projectile leaves the projector the high pressure existing in the cavity forces off the member 6. Another embodiment discloses the member having two recesses fitting over two parts formed between three slots cut in each fin.
Patent GB-1231362-A (GB)
IPC: G03C1/29
Filed: 1969-05-30
Abstract: 1,231,362. Supersensitized photographic silver halide emulsions. KONISHIROKU PHOTO INDUSTRY CO. Ltd. May 30, 1969 [June 4, 1968], No.27643/69. Heading G2C. A photographic silver halide emulsion is supersensitized with at least one sensitizing dye of each of the formulae: - wherein R 1  is alkyl, R 3  is H or alkyl, R 2  and R 4  are each alkyl or substituted alkyl, Y 1  is H, halogen, alkyl or aryl, Y 2  is H or methyl provided that Y 2  is methyl when Y 1  is chlorine, or Y 1  and Y 2  represent a fused-on benzene ring, Z completes a substituted or unsubstituted thiazole, thiazoline, benzothiazole or benzoselenazole ring, X is an acid anion, m is 1 or 2 and n is 2, 3 or 4. The emulsion preferably contains a magenta colour coupler and may contain the usual sensitizers and other additives.
Patent GB-1232241-A (GB)
IPC: C09B47/073
Filed: 1968-06-28
Abstract: 1,232,241. Preparation of phthalocyanine compounds. RANK XEROX Ltd. 28 .Tune, 1968 [3 July, 1967], No. 30958/68. Heading C4P. A process for the preparation of an organic pigment comprises (a) mixing an N-alkyl or di-alkyl-alkanolamine and a reactant selected from optionally substituted 1,3-di-imino-isoindolenine, a heterocyclic analogue of 1,3-diimino-isoindolenine or mixtures of these, (b) heating to reflux temperature, (c) maintaining this temperature for sufficient time to form the pigment preferably 10 mins.-7 hours. The preferred reactants include 2-dimethyl-aminoethanol, 1 - dimethylamino - 2 - propanol, 1 - di-ethylamino - 2 - propanol, and the 5-nitro-, 5-acetamido-, and 5-chloro-derivatives of 1,3-di-imino-isoindoline also the 4,5,6,7- tetrabromo derivative. Phthalocyanine pigments are produced.
Patent GB-1234241-A (GB)
IPC: D06M16/00
Filed: 1968-07-31
Abstract: 1,234,241. Unsymmetrical diphenyl carbonates. J. R. GEIGY A.G. 31 July, 1968 [1 Aug., 1967], No. 36424/68. Heading C2C. [Also in Division A5] The invention comprises compounds of the general Formula I wherein R 1  and R 2  which may be the same or different represent a hydrogen, fluorine, chlorine or bromine atom, the benzene ring B may be unsubstituted or be substituted by up to three fluorine, chlorine or bromine atoms and/or methyl or ethyl radicals and/or one or two trifluoromethyl groups, and the benzene ring C may be unsubstituted or be substituted by up to five fluorine, chlorine or bromine atoms and/ or one or three alkyl C 1-9  or alkoxy C 1-9  radicals and/or one or two trifluoromethyl groups and/or a phenyl radical which may be substituted by up to three chlorine or bromine atoms. They are prepared by reacting a hydroxydiphenyl ether of Formula II where R 1 , R 2  and B are as defined above with a chlorocarbonic acid ester of Formula III wherein C is as defined above, or with phosgene and a phenol of Formula IV or a 2-phenoxyphenyl chlorocarbonate of Formula V may be reacted with the phenol IV preferably in the presence of an acid-binding agent. 2 - (2<SP>1</SP>,4<SP>1</SP> - Dichlorophenoxy - 5 - chlorophenyl chlorocarbonate is prepared by reacting 4,2<SP>1</SP>,4<SP>1</SP> - trichloro - 2 - hydroxy - diphenyl ether with phosgene. The compounds of Formula I have bactericidal activity and may be used as additives in detergent compositions for the sterilization of textiles.
Patent GB-1239315-A (GB)
IPC: B23K37/053
Filed: 1969-08-19
Abstract: 1,239,315. Welding by fusion. M. MORI. 19 Aug., 1969 [19 Aug., 1968; 25 Sept., 1968], No. 41290/69. Heading B3R. Apparatus for aligning the ends of substantially cylindrical components 1, 2 comprises an adjustable linkage 3 adapted to be wound round one of the components for correcting the peripheral shape of the component and link plates 12 connected to the linkage and being adapted (by screws 15) to engage the second cylindrical component to vary its peripheral shape in accordance with variation in the first cylindrical component. The ends of the linkage are joined by screw-threaded shafts 6 and 7 which have intermeshing gears 9 and 10. A pin 5 is detachable to allow for varying the length of the linkage. The number of link plates can also be altered. In another embodiment the link plates do not have feet 14 to engage the first cylindrical component and are removably connected to the linkage via brackets, Figs. 6 and 7 (not shown). For connecting an end plate of curved form to a cylindrical section, the link plates have screws at either end, Fig. 5 (not shown).
Patent GB-1250818-A (GB)
IPC: H03F1/52
Filed: 1969-03-21
Abstract: 1,250,818. Transistor amplifier. RCA CORPORATION. 21 March, 1969 [1 July 1968], No. 14952/69. Heading H3T. [Also in Division H2] A circuit for impressing a bidirectionally variable voltage on a load, comprises two D.C.-D.C. converters 14, 18 applying oppositely poled variable outputs to the same terminal of a load 22, and a bias means e.g. a further converter 16 coupled in series between the two converters to prevent short circuiting of the two converters. Assume each D.C.-D.C. converter 14, 16, 18 is designed to provide 10,000 V across its output terminals 118, 120 when a voltage of 40V is applied across its input terminals 81, 96 and 5000 V output with 20 V input. With the supply 10 providing + 20 V at 32 and - 20 V at 34, 40 V is applied across the input of converter 16 and its output terminals 118, 120 are at - 5000 V and +5000V respectively. With no signal input from amplifier 20, terminal 11 is at earth potential and each of the converters 14, 18 have 20 V input and thus provide 5000 V output between their terminals 118, 120. With the rectifiers bridges as shown, the terminal 118 of converter 14 and the terminal 120 of converter 18 will thus be at earth potential, and no signal will be fed to load 22. As the input signal varies, the voltages applied to inverter 14, 18 will vary differentially to produce a corresponding variation in output which will result in an amplified signal being applied to load 22. Each converter includes a push-pull inverter which comprises transistors 82, 84, 104, 110, switching signals for which are derived via an amplifier 12.
Patent GB-1251495-A (GB)
IPC: B61C17/00
Filed: 1968-07-17
Abstract: 1,251,495. Controlling locomotives. HUDSWELL BADGER Ltd. 21 Aug., 1969 [17 July, 1968], No. 34114/68. Heading B7H. [Also in Division F1] A throttle control for an internal combustion engine driving, for example, a mines locomotive, comprises a fluid, i.e. air, actuated piston and cylinder connection 13 which is maintained in a rigid state under fluid pressure so long as the driver maintains a valve 10 open to permit the fluid to be supplied to the connection 13. Should the driver release the valve 10, the throttle control will become ineffective and if already in an open position the throttle will automatically return to an idle position by the collapse of the rigid state of the connection 13 resulting from relative movement of piston and cylinder achieved by a spring return. A threeway valve 12 may be included in the system which also couples the fluid system to the throttle valve 14 on the gear box such that for the period of gear change the connection 13 has its air supply cut off and the engine throttle brought to an idling condition. The valve 10 may be pedal operated and in addition to idling the engine in the event of the driver removing his foot from the pedal, the brakes of the vehicle may be simultaneously applied. This is achieved by connecting a diaphragm valve in the line to the valve 12 which diaphragm valve controls the flow to the brake cylinder of the vehicle, Fig. 2 (not shown). Superimposed on the above controls may be valve and fluid control devices which in the event of oil pressure failure connect the supply of air to the brakes to cause the brakes to be applied irrespective of whether the pedal valve 10 is operated or not. In addition, a temperature probe indicates whether the water cooling spray in the exhaust manifold is keeping the temperature down to the required level. If the temperature rises, a valve is operated which in turn opens air to an audible alarm. The air to the alarm is shut off when the engine is shut down, Fig. 3 (not shown). The above arrangements can be applied to a single end Diesel driven mines locomotive, but they may also be applied to a double end locomotive in which case two pedal valves 10 are incorporated in the systems one for each cab.
Patent GB-1252251-A (GB)
IPC: G01S3/14
Filed: 1966-11-15
Abstract: 1,252,251. Direction finding. CONTROL DATA CORP. 15 Nov., 1966 [15 Nov., 1965], No. 51249/66. Heading H4D. In an acoustical direction finding device formed of transducers 10, 12, forming a planar array, the spread of the pressure distribution curve 14, 16 is dependent on the angle of incidence of the received beam. Scarring the array along the path 18, at a fixed frequency, produces a signal, the frequency of which is a function of the angle of incidence. Movement of the incident beam relative to the array produces side bands. The elements of array 30, are separately coupled to the samplers 36, 36<SP>1</SP> driven by the clock 37. The swept analysers 46, 46<SP>1</SP> display spectra corresponding to positive or negative azimuth angles alone and eliminates ambiguity due to the sideband components. In an alternative form, 36<SP>1</SP> may be coupled to a bank of fixed filters each of which passes a frequency which corresponds to a specific beam angle.
Patent GB-1252805-A (GB)
IPC: C09J5/10
Filed: 1969-01-21
Abstract: 1,252,805. Bonded aluminium sheets. BOSTIK Ltd. 21 Jan., 1969 [22 Jan., 1968; 1 July, 1968], No. 3439/69. Heading B5N. [Also in Division C3] Aluminium sheets are bonded together by means of a cured composition provided by the use of two heat fusible, coilable rods of substantially uniform cross-section and composition throughout their length, which are dry and non- tacky and sufficiently stiff to be pushed into the entrance port of a melting device. Each of the two rods comprises synthetic polymeric material having chemical groups which react with chemical groups present in the other rod. Predetermined lengths of the two rods are melted and mixed together to form the composition. Examples of suitable materials for pairs of rods are: (1) (a) a material containing epoxy groups and (b) a material, containing groups capable of reacting with or catalysing the polymerization of epoxy groups, e.g. a polyamide containing primary amino groups or a material containing tertiary amino groups. (2) (a) a material containing blocked isocyanate groups, and (b) a second material containing reactive hydrogen atoms capable of reacting with the isocyanate groups which are unblocked when the polymer is melted. A suitable apparatus for dispensing the rods is described in Specification 749,892. Examples relate to the use of both types of composition as set out above which were applied to preheated aluminium and the two substrates lightly pressed together, on cooling a strong bond was formed.
Patent GB-1256473-A (GB)
IPC: A24F1/00
Filed: 1970-07-15
Abstract: 1,256,473. Smoker's pipe. W. H. STRAUSSER. 15 July, 1970 [14 Aug., 1969], No. 34350/70. Heading A2M. The stem 14 of a pipe 10 comprises a moisture trap 28 that includes a barrier wall 32 that leads to a moisture vent 30, and an annular groove 34 round which is wrapped a flexible strip of tape 36 to hold a moisture absorbing pad 38 in place over the outlet of the vent 30.
Patent GB-1289201-A (GB)
Inventor: KUENY D F
IPC: F01P7/16
Filed: 1970-04-14
Abstract: 1289201 Cooling IC engines OUTBOARD MARINE CORP 14 April 1970 [5 Jan 1970] 17639/70 Heading F1B A single or multi-stage I.C. engine, particularly a two-stroke marine engine, has a cooling jacket divided into first and second portions 63, 67 associated with the engine cylinders 27 and with the cylinder heads 35 respectively. Cooling water is delivered by an engine-driven flexiblevane pump 47 through conduit 55, upwardly around cylinders 27, through port 99 and downwardly along channels 87 to the downstream region of the first jacket portion. During idling, the water passes from this region through a restricted bypass passage 155 directly to discharge conduit 127 of second jacket portion, thereby allowing the cylinders to become relatively warm and the heads relatively hot. The by-pass passage may instead be constituted by a conventional by-pass port in thermostatically-operated valve 135 and by a restricted conduit between pocket 125 and discharge conduit 127, thereby permitting drainage of part of the second jacket portion. As the engine speed increases beyond idling the consequent increase in coolant temperature, e. g. above 140‹F., causes the thermostatically-operated valve 135 to open and allow the coolant to flow through the second jacket portion to maintain the cylinders and heads relatively warm. The second jacket portion has a central rib 109 therein which causes the coolant to follow an inverted U-shaped path to discharge conduit 127. Further increase in engine speed, and thereby pump speed and coolant pressure, causes a pressure-actuated valve 141 to open and permit a substantial increase in coolant flow, resulting in reduction of coolant temperature and consequent closure of valve 135, and causing the cylinders and heads to become relatively cool. Either of the valves 135, 141 may be omitted. The coolant discharged through conduit 127 is used to cool the exhaust pipe. Conduits 55, 127 and passage 155 allow drainage of the coolant when the engine is inoperative. Valves 135, 141 and the by-pass passage may be located in the main casting 71. The second jacket portion may instead be defined by a recess in cover 123.