Patent SG-11201407610W-A (SG)
Title: Cd33 antibodies and use of same to treat cancer
Inventor: SUTHERLAND MAY KUNG
IPC: C07K16/28
Filed: 2013-05-15
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 21 November 2013 (21.11.2013) WIPOIPCT (10) International Publication Number WO 2013/173496 A2 (51) International Patent Classification: C07K16/28 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/041209 15 May 2013 (15.05.2013) English English (30) Priority Data: 61/649,110 13/804,227 18 May 2012 (18.05.2012) US 14 March 2013 (14.03.2013) US (71) Applicant: SEATTLE GENETICS, INC. [US/US]; 21823 30th Drive Southeast, Bothell, Washington 98021 (US). (72) Inventors: SUTHERLAND, May Kung; 21823 30th Drive Southeast, Bothell, Washington 98021 (US). RYAN, Maureen; 21823 30th Drive Southeast, Bothell, Washing­ ton 98021 (US). SUSSMAN, Django; 21823 30th Drive Southeast, Bothell, Washington 98021 (US). BURKE, Patrick; 21823 30th Drive Southeast, Bothell, Washington 98021 (US). JEFFREY, Scott; 21823 30th Drive South­ east, Bothell, Washington 98021 (US). (74) Agents: LIEBESCHUETZ, Joe et al.; Alston & Bird LLP, 100 South Tyron Street, Bank of America Plaza, — Suite 4000, Charlotte, North Carolina 28280-4000 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: without international search report and to be republished upon receipt of that report (Rule 48.2(g)) [Continued on next page] (54) Title: CD33 ANTIBODIES AND USE OF SAME TO TREAT CANCER FIGURE 2 h2H12d h2H12d-SGD-1910 h0Qd-SGD-191O Mytotarg h2H12 h2H12-SGD-1269 hOO-SGD-1269 m2H12-SGD-1269 [ADC], ng/mi CJ o\ m i> • h2H12d • h2H12d-SGD-1910 O hOQd-SGD-tSIO • Mytotarg O h2H12 • h2H12-SGD-1269 x A hOO-SGD-1269 5 A i m2H12-SGD-1269 [ADCj, ng/mi i-H (57) Abstract: The invention provides murine, chimeric, and humanized antibodies that specifically bind to CD33. The antibodies © are useful for treatment and diagnoses of various cancers as well as detecting CD33. WO 2013/173496 A2 I lllll llllllll II llllll III lllll lllll lllll III III III lllll llll llll lllll lllll lllll lllllll llll llll — with sequence listing part of description (Rule 5.2(a))