baber/WOPTO huggingface dataset:
Patent EA-017945-B1 (EA)
Title: Compositions and methods for the treatment and prevention of fibrotic, inflammatory and neovascularization conditions of the eye of an animal
Inventor: SABBADINI ROGER A
IPC: A61K39/395
Filed: 2006-10-27
Abstract: The present invention relates to compositions and methods for the treatment and prevention of diseases and pathologic conditions of the eye of an animal characterised by aberrant fibrogenesis, or scarring, inflammation and/or aberrant neovascularization or angiogenesis. The compositions and methods of the invention utilize a monoclonal antibody that is reactive against sphingosine-1-phosphate (S1P) or an antigen-binding fragment thereof.
Patent EA-014355-B1 (EA)
Title: Slurry polymerisation process of ethylene in the presence of low amount of scavenger
Inventor: MIUSERQUE OLIVER
IPC: C08F2/14
Filed: 2007-03-29
Abstract: The invention discloses a metallocene catalysed slurry polymerisation process of ethylene in the presence of a low concentration of scavenger. This allows improving the anti-sheeting of the reactor during the polymerisation process.
Patent EA-017015-B1 (EA)
Title: Toltrazuril with improved dissolution properties
Inventor: TIHI JAROSLAV
IPC: A01N43/66
Filed: 2009-04-03
Abstract: The present invention relates to toltrazuril particles with improved dissolution properties and specific surface area of 4 to 40 m/g. The particles are prepared by suspending toltrazuril in a solvent, then dissolving toltrazuril with a basifying agent, then precipitating toltrazuril with an acidifying agent and separating precipitated toltrazuril.
Patent EA-028356-B1 (EA)
Title: Treatment and prophylaxis of amyloidosis
Inventor: SCHENK DALE B
IPC: C12P21/08
Filed: 2008-12-29
Abstract: Disclosed are methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a C-terminal region of AA, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the C-terminal region of AA fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effect prophylaxis or treating amyloid disease.
Patent EA-020269-B1 (EA)
Title: Eccentrically cycloidal engagement of toothed profiles (variant embodiments)
Inventor: STANOVSKOY VIKTOR VLADIMIROVICH
IPC: F16H1/08
Filed: 2011-01-17
Abstract: The eccentrically cycloidal engagement of toothed profiles relates to mechanical transmissions for converting rotary motion into rotary or reciprocal motion and can be used in cylindrical, conical or planetary reduction gears and also rack and pinion drives, which have a high gear ratio, small dimensions and a high load carrying capacity. One of the profiles is in the form of a wheel with a single spiral tooth. The working part of the tooth is described in the principal cross-sections by arcs (6, 7) of a circle (8) which is eccentrically offset from the axis of rotation of the wheel. The mating working surface of the teeth of the second profile is described in the principal cross-sections by portions of the fronts (14, 15) of a cycloidal curve (16). The tips (17) and troughs of the cycloidal teeth are described by arcs of coaxial circles (19, 21). The design of the profiles makes it possible to reduce the surface requiring precision machining.
Patent EA-024506-B1 (EA)
Title: Circuit configuration for operating a household appliance, household appliance comprising this configuration, and method for operating a household appliance
Inventor: ALBAYRAK HASAN GOEKCER
IPC: D06F34/10
Filed: 2011-08-11
Abstract: The invention relates to a circuit configuration for operating a household appliance, such as washing and/or drying machine, having an electric drive motor, and to a method allowing proper operation of a household appliance after an AC power supply Uhas failed. The circuit configuration (1) comprises a motor control unit (6) and a main control unit (18). The motor control unit (6) is supplied with electrical energy Uwith the aid of a motor supply circuit (7). The motor supply circuit (7) comprises an intermediate circuit capacitor (14) for storing electrical voltage. The main control unit (18) is supplied with electrical energy Uby a main supply unit (19). After the AC power supply Ufails, the main control unit (18) is supplied with electrical energy Ufrom the intermediate circuit capacitor (14). Uncontrolled shutoff of the main control unit (18) and the motor control unit (6) can thereby be avoided.
Patent EA-023403-B1 (EA)
Title: Fermentation method
Inventor: SCHULTZ MICHAEL
IPC: C12R1/145
Filed: 2011-12-19
Abstract: This invention relates to the integration of an ammonia production process with a fermentation process to produce products such as alcohols and/or acids in addition to ammonia. In a specific embodiment, a natural gas stream comprising methane is passed to a reforming zone to produce a substrate comprising CO and H. The substrate is next passed to a bioreactor containing a culture of one or more microorganisms and fermenting the culture to produce one or more fermentation products comprising alcohols and/or acids and an exhaust stream comprising CO, and H. The exhaust stream can then be passed to a separation zone to remove at least a portion of the COand produce a purified exhaust stream comprising Hwhich is then passed to an ammonia production zone and is used to produce ammonia.
Patent EA-030252-B1 (EA)
Title: Ph20 polypeptede variants, formulations and uses thereof
Inventor: WEI GE
IPC: C12N9/26
Filed: 2012-12-28
Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided herein are compositions and formulations and uses thereof.
Patent EA-027597-B1 (EA)
Title: Composition with probiotic, hepatoprotective, antioxidant and immune modulating activity
Inventor: SINITSA ALEKSANDR VLADIMIROVICH
IPC: C12R1/125
Filed: 2014-10-09
Abstract: The invention relates to the field of medicine and involves composition that can improve body vital function in conditions of exposure to different aggressive factors due to complex probiotic, hepatoprotective, antioxidant, and immune modulating activity via supporting normal intestinal flora, improving functional condition of liver, activation of body antioxidant system, and enhancing immunity. The disclosed composition is designed in solid dosage form as 500 mg capsules and contains following ingredients, mg per capsule: sterilized lyophilisate of cultural fluid, containing biologically active metabolites of bacteria Bacillus subtilis strain RNCIM No. B-2335 - 4.0; Phyllanthus amarus leaves extract - 50.0; taurine - 250.0; zeolite - 196.0.
Patent EA-025598-B1 (EA)
Title: Active organic coating for application to titanium implants and method for producing the same
Inventor: YASINOV MIKHAIL GRIGORIEVICH
IPC: A61L27/54
Filed: 2015-01-22
Abstract: The invention is related to the field of medicine, in particular, to dentistry, and can be used as a coating for dental implants. The organic coating for titanium implants comprises, as a base, polysaccharides sodium alginate and calcium alginate, and as anti-inflammatory and anti-microbial components it includes dense oak bark extract and liquid extracts of nettle, milfoil and St.John's wort in the following proportion (% by mass): sodium alginate - 30-35; calcium alginate - 25-30; dense oak bark extract - 10-15; liquid nettle extract - 8-10; liquid milfoil extract - 8-10; liquid St.John's wort extract - 8-10. The proposed material makes it possible to reduce the period and to increase the degree of implant survival by stimulation of osteoblast proliferative activity and, therefore, activation of reparative osteogenesis processes, and suppression of pathogenic microorganisms activity at the place of implant introduction.
Patent EA-028244-B1 (EA)
Title: ANTI-PCSK9 ANTIBODIES WITH pH-DEPENDENT BINDING CHARACTERISTICS
Inventor: YANCOPOULOS GEORGE D
IPC: C07K16/40
Filed: 2013-08-12
Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind proprotein convertase subtilisin/kexin-9 (PCSK9) with greater affinity at neutral pH than at acidic pH. The antibodies disclosed herein may possess one or more amino acid changes as compared to antibodies that do not exhibit pH-dependent binding properties. For example, the present disclosure includes anti-PCSK9 antibodies which possess one or more histidine substitutions in one or more complementarity determining regions. The antibodies disclosed herein, with pH-dependent binding properties, remain in circulation and exhibit cholesterol lowering activity for prolonged periods of time in animal subjects as compared to anti-PCSK9 antibodies that do not exhibit pH-dependent binding properties. The antibodies disclosed herein are therefore useful for treating diseases and disorders related to elevated HDL cholesterol, wherein the antibodies disclosed herein can be administered to a patient at a lower dose and/or with less frequent dosing as compared to antibodies that do not exhibit pH-dependent binding properties.
Patent EA-037849-B1 (EA)
Title: Fusion protein, dna, genetic construct, producer, fusion protein-based vaccine for tuberculosis prevention and treatment (versions)
Inventor: DUKHOVLINOV ILYA VLADIMIROVICH
IPC: C12N15/31
Filed: 2016-05-24
Abstract: The invention relates to molecular biology, biotechnology, medicine and cane be used for preventing and treating tuberculosis. Fusion proteins are proposed including immunogenic fragments of Ag85B proteins, Tb10.4 M.tuberculosis, FliC S.Typhimurium, connected by flexible bridges, encoding polynucleotides, genetic constructs for expression of polynucleotides, producers and vaccine options for tuberculosis prevention and treatment based on the described fusion protein, vaccine is developed for humans or animals. The proposed vaccine has an efficiency exceeding that of BCG. The invention claimed for producing said vaccine provides its security and simplicity in production and application.
Patent EA-039937-B1 (EA)
Title: Downhole electrochemical sensor and method of using same
Inventor: LAWRENCE NATHAN
Filed: 2014-11-06
Abstract: An electrochemical sensor of a downhole tool positionable in a wellbore penetrating a subterranean formation is provided. The downhole tool has a flowline to receive downhole fluid. The electrochemical sensor includes a bulkhead carried by the downhole tool, a membrane exposed to the downhole fluid in the flowline, and an electrochemical cell supported by the bulkhead about the membrane. The electrochemical cell includes a plurality of cell sensors, at least one cell electrode, and a sensing solution. The plurality cell sensors include an analyte sensor, a temperature sensor, and a pH sensor. The sensing solution is reactive to certain analytes in the downhole fluid to generate electrical signals measurable by the plurality of cell sensors whereby parameters of chemicals in the downhole fluid may be measured.
Patent EA-032541-B1 (EA)
Title: Macrocyclic compounds
Inventor: LUECKING ULRICH
IPC: A61K31/529
Filed: 2015-04-08
Abstract: The present invention relates to novel macrocyclic compounds of general formula (I)as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyperproliferative disorders and/or virally induced infectious diseases and/or cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
Patent EA-033875-B1 (EA)
Title: Farm for rearing insects
Inventor: COMPARAT SOLENE
IPC: B65G57/00
Filed: 2016-04-13
Abstract: The present invention relates to a farm for rearing insects, comprising a first zone (Z1) in which the insects being reared are stored in containers while they grow and a second zone (Z2) comprising at least one station configured for effecting a rearing-related task on the insects in a container or thereon. The containers are grouped in the first zone (Z1) in sets of palletized containers referred to as basic units. The first zone (Z1) is furthermore equipped with an automated device configured to move the basic units between the first zone (Z1) and an interface (1) with the second zone (Z2).
Patent EA-035780-B1 (EA)
Title: Water-heating boiler
Inventor: ORUMBAEV RAKHIMZHAN KABIEVICH
IPC: F24H9/14
Filed: 2019-05-06
Abstract: The invention relates to hot water boilers and can be used in decentralized heat supply systems of residential and industrial buildings. The hot water boiler contains a prismatic furnace consisting of parallel pipes with collectors and partitions assembled in a U-shaped inner all-welded wall and an outer partial division convective wall. The ceiling and the front walls are designed as all-welded parts. The outer convective wall is combined with the inner wall, and each of them is connected with the first and second vertical collectors. Centerlines of pipes of the outer convective wall are shifted by half the longitudinal pitch s/2 from the centerline of pipes of the inner wall and are located at a distance sfrom them along the U-shaped perimeter. The thermally-insulated reflector is located at a distance sfrom the centerline of pipes of the outer convective wall and forms a checkered double-row channel element. The front and ceiling walls with collectors are rotated by 90 relative to the superimposed U-shaped inner wall and the convective wall and are connected in series. The upper rear collector of the ceiling wall is installed between the right and the left upper longitudinal side collectors, and the left longitudinal side collector is connected in series with the left outer front collector. The right outer front collector is connected to the right inner front collector with two partitions, and on the top it is connected to the outlet nipple of the boiler. In each line, the number of parallel pipes decreases in the high-temperature zone and increases with the distance from the flame.
Patent EA-037417-B1 (EA)
Title: Method for developing practical skills of auscultation with the help of medical simulator
Inventor: ZAJNULLIN RAMIL KHATYAMOVICH
IPC: G09B23/28
Filed: 2019-10-03
Abstract: The invention relates to the field of medicine. A dummy man including a simulated cardiopulmonary resuscitation system, a defibrillator simulation system, a chest decompression simulation system, a pleural cavity drainage procedure simulation system, a tracheal intubation and conicotomy simulation system, a drug injection simulation system, a bleeding simulation system, and bladder catheterization simulation system is used. Voice coils are built into the dummy, which interact with a permanent magnet mounted on the membrane of the acoustic head of the stethoscope. Depending on the training scenario used, sound signals of functioning the internal organs are simulated, physical effects on a human dummy are carried out for resuscitation or medical procedures. The physical effects exerted on the mentioned imitation systems or their absence is recorded. The data on the impacts are transmitted to a computer for processing, and sound signals are simulated, and transmitted to the voice coil system for playback them through the acoustic head of the stethoscope. The technical result is to provide comprehensive training for doctors.
Patent EA-038704-B1 (EA)
Title: Clutch and method for the production thereof
Inventor: KRONDORF MARTIN
Filed: 2018-07-12
Abstract: The invention relates to the field of mechanical engineering and concerns a clutch that can be used, for example, in vehicle drives, in particular rail vehicle drives. It is the problem of the invention to specify a clutch, by way of which the electric contact between the drive side and the output side of the clutch is prevented reliably, and to specify a simple and inexpensive method for the production thereof. The problem is solved by way of a clutch, at least consisting of a clutch half on the drive side and a clutch half on the output side, wherein at least one clutch half has at least two hollow cylinders which are arranged above one another and are arranged in a bore of the clutch half, wherein the second hollow cylinder consists of electrically insulating material, and wherein at least the first hollow cylinder, at least on its outer circumferential surface, and at least the inner circumferential surface of the bore have knurling at least in part.
Patent EA-037829-B1 (EA)
Title: Extraction device for a tuyere part
Inventor: THINNES CLAUDE
IPC: C21B7/16
Filed: 2018-08-02
Abstract: Described herein is an extraction device for extracting a tuyere part, in particular a tuyere or a tuyere cooler, from a shaft furnace, the device comprising a supporting frame with positioning elements configured to position the device against a furnace wall. The device also comprises a carriage supported by the supporting frame. The carriage is movable in a direction radial to the furnace wall. The device further comprises an extraction rod having a first end attached to the carriage and a second end for connecting to the tuyere part, wherein the first end of the extraction rod comprises a stopper. The device also comprises a percussion system acting on the stopper of the extraction rod in a direction away from the furnace wall. The device comprises a pretensioning mechanism on the supporting frame. The pretensioning mechanism is configured to apply a load to the carriage, in a direction away from the furnace wall.
Patent ES-2200670-B1 (ES)
Title: Linea celular de celulas madre embrionarias de dorada.
Inventor: ALVAREZ HERRERO MARIA DEL CAME
IPC: C12N5/02
Filed: 2002-02-04
Granted: 2005-03-01
Abstract: Línea celular de células madre embrionarias de dorada. Se presenta una línea de células madre embrionarias (STEM) de la especie piscícola Sparus aurata (dorada), denominada SaBE-1c. Es una línea clonal obtenida a partir de un cultivo celular heterogéneo (SaBE-1), procedente de células embrionarias del blastodisco de la propia especie. Presenta las siguientes características típicas de células totipotentes: pequeño tamaño, forma poligonal, crecimiento en cultivo muy compacto, tiempo de duplicación de la población celular de 30 horas, cariotipo euploide estable, actividades elevadas de fosfatasa alcalina y telomerasa, capacidad de diferenciarse a distintos tipos celulares, capacidad de formar cuerpos embrioideos cuando se cultiva en suspensión, así como la capacidad de participar en distintos linajes celulares cuando se transplantan a un embrión receptor para producir organismos quimera. La identidad genética de esta línea se ha llevado a cabo mediante el genotipado con tres loci microsatélites.
Patent ES-2237239-B1 (ES)
Title: Caja-precinto de carton.
Inventor: VEGA FERNANDEZ EDUARDO
IPC: B65D5/10
Filed: 2002-10-18
Granted: 2006-10-01
Abstract: Caja-precinto de cartón. A partir de un cuerpo tubular (3), de sección rectangular, prolongado por su embocadura en una pluralidad de solapas de cierre, una de las solapas (7) que forman parte de su fondo, la destinada a montarse en último lugar a la mano de dicho fondo, incorpora en sus fondos laterales y cerca de sus extremos libres sendas aletas (15) desgarrables a través de líneas de precorte (14), de manera que ante un intento de abrir la caja por su fondo se produce ineludiblemente la rotura de dichas aletas (15). Por su parte las solapas (9) y (11) que participan en el cierre de su embocadura, cuentan a su vez con aletas (16) y (22), enchufables en ranuras (20) y (23), solapas con prolongaciones laterales (19) que tras atravesar las citadas ranuras se expanden bloqueando a las aletas (16) y (22) impidiendo también la apertura por esta zona superior, sin que se produzca la rotura de dichas aletas (16) y (22). Esto permite que la caja actúe por sí sola como precinto evidenciando que durante su transporte se ha producido una apertura de la misma y una consecuente manipulación indebida sobre su contenido.
Patent ES-2258391-B1 (ES)
Title: Aducto de ovoalbumina soluble con complejos polialcoholicos de hierro trivalente y metodo para su obtencion.
Inventor: DIAZ VICTOR BAUTISTA
IPC: C07K14/435
Filed: 2004-11-03
Granted: 2007-12-01
Abstract: Aducto de ovoalbúmina soluble con complejos polialcohólicos de hierro trivalente y método para su obtención. Se trata de aductos solubles en agua con complejos de polialcoholes monosacáridos con hierro trivalente con ovoalbúmina soluble y desensibilizada, para la formación de composiciones farmacéuticas o veterinarias junto con excipientes aceptables, o composiciones dietéticas junto con otros aditivos opcionales, empleados para el tratamiento de estados carenciales de hierro en personas o animales; siendo el polialcohol un compuesto que contiene más de un grupo hidroxilo y que es capaz de formar complejos con hierro (III), la ovoalbúmina ha sido sometida a un proceso térmico, alcalino, enzimático y oxidante para su solubilización y purificación, sin afectar mayormente a su peso molecular, destruyendo a la vez impurezas indeseables y fenómenos de alergia e inmunotoxicidad, el aducto se obtiene mezclando la solución del complejo férrico con la solución de ovoalbúmina tratada.
Patent ES-2275399-B1 (ES)
Title: "dispositivo de ajuste para el sistema de seguimiento de colectores parabolicos".
Inventor: EICKHOFF MARTIN
IPC: F24S50/20
Filed: 2005-05-12
Granted: 2008-04-16
Abstract: Dispositivo de ajuste para el sistema de seguimiento de colectores cilindro parabólicos. Para el ajuste básico inicial del sistema de seguimiento de un colector cilindro parabólico respecto a su orientación óptima al sol se mide la radiación solar reflejada por el espejo cilindro parabólico (11) que no alcanza el tubo absorbente. Con este objeto, se instalan paneles (25) con células fotovoltaicas sobre todos los segmentos absorbedores (14) del colector. Los paneles generan una señal en forma de corriente eléctrica que es proporcional a la radiación que no alcanza el tubo absorbente. Para el ajuste básico inicial del colector se ajusta la posición del colector respecto al sol, de tal manera que se mida un mínimo de corriente, lo que significa que en esta posición un máximo de la radiación alcanza el tubo absorbente del colector. Partiendo de este ajuste inicial, el sistema de seguimiento sigue manteniendo este ángulo óptimo entre colector y sol durante la futura operación.
Patent ES-2358710-B1 (ES)
Title: Máquina para la aplicación de recubrimientos de paneles.
Inventor: BARBERAN LATORRE JESUS FCO
IPC: B05C1/02
Filed: 2008-05-23
Granted: 2012-02-14
Abstract: Máquina para la aplicación de recubrimientos de paneles, en la cual se halla provisto un conjunto de aplicación de cola que comprende un cabezal aplicador (7) de rodillos, un cabezal aplicador (10) de labio y un rodillo de transferencia (11), los cuales son susceptibles de desplazamiento individual entre posiciones de trabajo y de reposo, permitiendo realizar de distintas formas el encolado para la fijación de un folio de recubrimiento (3) sobre los paneles a recubrir, antes del paso por unos rodillos de calandrado (4) que son independientes de las formas de encolado.