baber/WOPTO huggingface dataset:
Patent CA-3038480-A1 (CA)
Title: Compound usable as cationic lipid
Inventor: HOSOE SHINTARO
IPC: A61K31/7088
Filed: 2017-09-27
Abstract: The present invention provides a compound represented by formula (I), which is usable as a cationic lipid facilitating the introduction of a nucleic acid into a cell, or the like, and a composition, or the like, containing the compound.
Patent CA-3039283-A1 (CA)
Inventor: BAUER ANDREAS
IPC: A61K31/46
Filed: 2017-10-03
Abstract: L'invention concerne des compositions pharmaceutiques comprenant un agoniste du récepteur farnesoïde X (FXR) et un autre agent thérapeutique, en particulier pour traiter ou prévenir des maladies ou des troubles hépatiques.
Patent CA-3040526-A1 (CA)
Title: Pyrazole amide compounds as irak inhibitors
Inventor: TSO KIN
IPC: C07D471/04
Filed: 2017-10-25
Abstract: Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors of formula 1 and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/ or compositions may be used to treat or prevent an IRAK-associated disease or condition.
Patent CA-3044632-A1 (CA)
Inventor: MCISAAC FRANK
IPC: F16B37/10
Filed: 2019-05-29
Abstract: A split nut with an outer body and an inner body formed of two jaws for gripping a threaded rod. The outer body has an inner surface defining tapered axial channel and includes a separator between the jaws to guide the jaws against an inner surface of the tapered axial channel. The inner surface can be circular in cross section and the outer body can also have an outer surface be circular in cross section. A lock is arranged to lock the jaws in an axial position at which the jaws are sufficiently close to force the jaws into threaded engagement with the threaded rod. The lock can also lock the jaws in an additional axial position at which the threaded rod can be moved freely axially between the jaws. The lock can comprise a locking pin movable within the outer body into respective slots corresponding to each locking position.
Patent CA-3044747-A1 (CA)
Title: Well kickoff systems and methods
Inventor: XIAO JINJIANG
IPC: F04B47/02
Filed: 2017-11-29
Abstract: Systems (10) and methods for removing fluid from a subterranean well (12) with a fluid removal system includes lowering an elongated member (26) into tubing (20) of the subterranean well (12) to a lower position, the elongated tubing having a plunger (29) or valve body (28) located at an end, wherein fluid passes past the plunger or through a valve opening (32) as the valve body moves into the subterranean well. The plunger or valve body (28, 29) is moved in a direction out of the subterranean well (12) so that fluid cannot pass the plunger or through the valve opening, moving the fluid out of the subterranean well.
Patent CA-3046615-A1 (CA)
Title: Strap tie-down
Inventor: TAYLOR CURTIS
IPC: F16G11/12
Filed: 2019-06-14
Abstract: An improved strap tie-down device that includes two primary components, namely a base frame and a lever arm, and further includes a cam and a locking mechanism.
Patent CA-3049738-A1 (CA)
Title: Interaction between c-peptides and elastin receptor, a model for understanding vascular disease
Inventor: WENSVOORT GERT
IPC: G01N33/564
Filed: 2018-02-05
Abstract: The invention shows that inflammation in metabolic syndrome is augmented by a hitherto overlooked lock- and-key activation of the elastin receptor, a protein involved in vascular (blood vessel) inflammation and elastin repair, with the C-peptide, a small protein that is produced in a 1:1 ratio alongside with widely known insulin. The elastin receptor is the lock that is activated by a key motif of amino acids (PG-domain) found in C-peptide and in breakdown products (PG- domain-fragments) thereof. Until now, no one has ever discovered this lock-and-key interaction between the two, now providing novel inroads in diagnosis, prevention and development of novel compounds for treatment of metabolic syndrome, exploiting the finding that not only the normal keys of the elastin receptor (elastin peptides), but also the C-peptide, a peptide we produce together with insulin every time glucose rises in our blood after a meal, interacts in a lock-and-key mode with the elastin receptor.
Patent CA-3051009-A1 (CA)
Inventor: ARLINGHAUS PAUL RAYMOND
IPC: E05B65/10
Filed: 2014-12-30
Abstract: Linvention concerne un mécanisme de surcourse conçu pour coupler un arbre dentrée et un arbre de sortie dans un ensemble de dispositif de sortie. Larbre dentrée est raccordé à un actionneur qui déplace larbre dentrée de façon linéaire, et larbre de sortie est raccordé à un élément de verrouillage du dispositif de sortie. Le mécanisme de surcourse comprend une liaison couplée à larbre de sortie, et un élément élastique préchargé transmet une force entre larbre dentrée et la liaison. Le passage de larbre dentrée dune première position darbre dentrée à une deuxième position darbre dentrée commande à lélément élastique de faire passer la liaison dune première position de liaison à une deuxième position de liaison. Le passage de larbre dentrée de la deuxième position darbre dentrée à une troisième position darbre dentrée commande à lélément élastique de se déformer élastiquement sans déplacer la liaison de la deuxième position de liaison.
Patent CA-3057432-A1 (CA)
Inventor: NISHIDA KEIJI
IPC: C12N15/09
Filed: 2018-03-20
Abstract: La présente invention concerne un procédé de modification d'un site ciblé d'ADN possédé par une cellule, le procédé comprenant une étape de stimulation de la cellule par un facteur qui induit une enzyme de modification d'ADN inhérente à la cellule et de mise en contact de l'ADN avec un complexe dans lequel un module de reconnaissance de séquence d'acide nucléique, qui se lie spécifiquement à une séquence nucléotidique cible dans l'ADN sélectionné, et un module de liaison d'enzyme de modification d'ADN sont liés, ce qui permet de convertir un ou plusieurs nucléotides du site ciblé en un ou plusieurs autres nucléotides, de supprimer ledit un ou lesdits plusieurs nucléotides ou d'insérer ledit un ou lesdits plusieurs nucléotides dans le site ciblé.
Patent CA-3064337-A1 (CA)
Inventor: MAORI EYAL
IPC: A23F5/48
Filed: 2018-05-31
Abstract: L'invention concerne un caféier comprenant un génome comprenant une mutation perte-de-fonction dans une séquence d'acide nucléique codant pour l'alpha-D-galactosidase. L'invention concerne également un procédé d'augmentation de l'extractibilité de solides en provenance de grains de café. De plus, l'invention concerne un procédé de production de café soluble.
Patent CA-3066230-A1 (CA)
Title: Cooling method for reactor molten core melt and cooling control system for reactor molten core
Inventor: Sidorov Aleksandr Stalevich
IPC: G21C9/016
Filed: 2018-12-28
Abstract: The invention relates to safe operation support systems of nuclear power plants (NPPs) at severe accidents, in particular, to methods and systems for cooling and cooling control of the reactors molten core. The technical result of the claimed inventions is to increase the safety of NPP, cooling efficiency of the molten core of a reactor. The objective of the claimed inventions is to increase the efficiency of cooling the molten core of a reactor by safely removing the heat load from the molten metal mirror, ensuring the elimination of vapour explosions leading to the destruction of the localization area of accidents, the reactor cavity and the containment. The technical result is achieved by changing the principle of cooling the reactor molten core, which consists in the fact that after the molten core destroys the reactor vessel, the conditions for subsequent cooling of the molten metal are determined by the characteristics of the trap casing, but not of the reactor. Besides, the technical result is achieved due to the installation of temperature sensors and level gauges designed to monitor the cooling process of the molten core of a reactor.
Patent CA-3071528-A1 (CA)
Inventor: RADIN ALLEN
IPC: C07K16/28
Filed: 2018-08-03
Abstract: The present invention provides methods for treating, preventing or reducing the severity of active eosinophilic esophagitis. In certain embodiments, the present invention provides methods of increasing esophageal distensibility. The methods of the present invention comprise administering to a subject in need thereof a therapeutic composition comprising an interleukin-4/ interleukin-13 (IL-4/IL-13) pathway inhibitor such as an anti-IL-4R antibody.
Patent CA-3072502-A1 (CA)
Title: Soft tissue balancing in articular surgery
Inventor: COUTURE PIERRE
IPC: A61B5/11
Filed: 2017-06-16
Abstract: Systems and methods may be used to perform robot-aided surgery. A system may include a robotic controller to monitor a position and orientation of an end effector coupled to an end of a robotic arm. The robotic controller may apply a force to a bone using the end effector, such as via a soft tissue balancing component. The robotic controller may determine soft tissue balance using information from a tracking system, such as a position of a first tracker affixed to the bone. The soft tissue balance may be output, such as to a display device.
Patent CA-3072815-A1 (CA)
Title: Modular carriage assembly for the fusion of polyolefin pipes
Inventor: MCELROY ARTHUR H
IPC: B29C65/02
Filed: 2018-09-19
Abstract: Modular carriage for varying spacing between ends of polymer pipe during fusion. The modular carriage (10) includes a fixed jaw (12); an inner movable jaw (14); an outer moveable jaw (16) and a plurality of guide rods (24/26). The fixed jaw (12) being adapted for tool free engagement with the terminal ends of the plurality of guide rods (24/26). A carriage cylinder (32/34) is associated with at least two of the guide rods (24/26) and mounted for reciprocal travel along the length of its associated guide rod. The movable jaws (14/16) being adapted for tool free engagement with at least two carriage cylinders (32/34) for reciprocal travel therewith. A combined hydraulic cylinder/guide rod (80) includes a guide rod (82) with an integral guide rod piston (88), a cylindrical tube (84), and a guide rod gland on each end of the cylinder tube (84).
Patent CA-3078462-A1 (CA)
Title: Device for centring and/or pulling a tool in a pipeline
Inventor: SANTOS HUGO FRANCISCO LISBOA
IPC: E21B23/14
Filed: 2018-10-09
Abstract: The present invention relates to a device for centring and pulling a tool in a pipeline, the device comprising expanding arms, with each expanding arm comprises a wheel suitable for making contact with an inside wall of a pipeline, wherein each wheel comprises at least one magnetic element.
Patent CA-3081507-A1 (CA)
Title: Vaporizing device
Inventor: GOMEZ LEONARDO
IPC: A24F40/40
Filed: 2020-05-29
Abstract: A vaporizing device for vaporizing aromatic substances is provided. The vaporizing device includes a heat exchanger configured to heat fresh air to a sub-combustion vaporizing temperature while maintaining the fresh air free from combustion byproducts. The vaporizing device further includes an internal heating cavity configured to permit heating of the aromatic substance via convection.
Patent CA-3082177-A1 (CA)
Title: Control of energy storage to reduce electric power system off-nominal frequency deviations
Inventor: VARTANIAN CHARLES K
IPC: H02J3/24
Filed: 2020-06-02
Abstract: A hybrid power generation system is formed by the combination of an energy storage system (ESS) and a rotating synchronous power generator (SPG). Energy is stored in or released from the ESS in response to measurements of the at least one angle parameter, selected from rotor, torque, or power angle of the SPG, to provide active frequency damping of electrical power output. The control of ESS energy exchange increases the stabilizing impact of the SPG inertia on the frequency of electricity in an electrical network or power grid. The hybrid power generation system can have an effective equal area criterion for stability limit that is greater than that of the SPG operating without the ESS. The hybrid power generation system can enable the electrical network to have a greater proportion of variable or distributed energy resource (DER) power generation systems without otherwise exceeding stability limits.
Patent CA-3082495-A1 (CA)
Inventor: SHI ZHIHUA
IPC: H04L29/06
Filed: 2017-11-14
Abstract: Selon les modes de réalisation, la présente invention concerne un procédé et un dispositif de communication sans fil, permettant d'améliorer la flexibilité dans une radiomessagerie ou dans la transmission de messages de diffusion. Le procédé comprend les étapes suivantes : un dispositif de réseau détermine un mode de radiomessagerie d'un dispositif terminal ou transmet un message de diffusion au dispositif terminal, le mode déterminé étant un premier mode ou un second mode, un premier ensemble de paramètres étant utilisés dans la radiomessagerie ou dans la transmission du message de diffusion à un point de fréquence spécifique dans le premier mode et un second ensemble de paramètres étant utilisés dans la radiomessagerie ou dans la transmission du message de diffusion à un point de fréquence spécifique dans le second mode ; et le dispositif de réseau, selon le mode déterminé, téléavertit le dispositif terminal ou transmet le message de diffusion au dispositif terminal au point de fréquence spécifique.
Patent CA-3085134-A1 (CA)
Inventor: SALAZAR ABRAHAM J
IPC: B05B14/43
Filed: 2018-12-14
Abstract: L'invention concerne une cabine de pulvérisation spécialement adaptée à des opérations de peinture et comportant un module de filtre sec pourvu de caractéristiques pour permettre le changement des filtres rapidement et dans un environnement confiné, ce qui réduit l'exposition à un personnel non autorisé et non correctement protégé. Un module de filtre de type carrousel retourne une paroi pour déplacer des filtres sales dans un espace de confinement tout en plaçant des filtres propres en position pour continuer le processus de mise en peinture. Le procédé et le dispositif selon la présente invention sont sans danger, peuvent être répétés, anticipés, et permettent de changer un grand nombre de filtres sur une courte période de temps, par exemple, pendant une pause déjeuner ou autre pause brève, lors de l'opération de mise en peinture.
Patent CA-3086354-A1 (CA)
Inventor: ERHEL PHILIPPE
IPC: A47C7/50
Filed: 2018-12-18
Abstract: A passenger seat includes a bottom support to be connected to the aircraft floor, a seat pan frame, and a support structure interconnecting the seat pan frame to the bottom support. A front support member defines a frontmost portion of the support structure, and has a top end connected to a front end of the seat pan frame and a bottom end connected to the bottom support. The front end of the seat pan frame is forwardly offset from a front end of the bottom support and the top end of the front support member is forwardly offset from its bottom end such that an empty space is defined across a width of the seat between the seat pan frame and the floor, forwardly of the support structure, forwardly of the bottom support, and rearwardly of a vertical plane aligned with the front end of the seat pan frame.
Patent CA-3087564-A1 (CA)
Inventor: COLISTER GARY
IPC: G16H50/20
Filed: 2019-01-03
Abstract: A system for improving patient outcomes, including a telecommunications network; monitoring equipment for receiving and sending data via the network, and instructions for receiving data and accessing patient medical conditions; a patient database; a communication hub with instructions for collecting data and transmitting data to electronic devices and for storing data; a data storage engine including means for collecting data from electronic devices and instructions for transmitting data to any number of electronic devices; the telecommunication network providing access to all data, including continuous wave form, collected during treatment and quality data not included in any patient record storage location; and a user interface rules engine that provides the user with ability to select any point in time during the patient treatment to review details and create guidance rules so that data can be acquired, consolidated and actionable insights can be delivered in near-real time.
Patent CA-3087926-A1 (CA)
Title: Pyrazolopyrimidines substituees par cycloalkyle ayant une activite contre le vrs
Inventor: LANCOIS DAVID FRANCIS ALAIN
IPC: A61K31/519
Filed: 2019-01-30
Abstract: L'invention concerne des composés de formule (I) ayant une activité antivirale, en particulier, ayant une activité inhibitrice sur la réplication du virus respiratoire syncytial (VRS). L'invention concerne en outre des compositions pharmaceutiques comprenant ces composés et les composés destinés à être utilisés dans le traitement d'une infection par le virus respiratoire syncytial. (Formule I)
Patent CA-3089277-A1 (CA)
Inventor: AUBIN-WALKER SHEILA
IPC: C12Q1/6818
Filed: 2019-02-06
Abstract: L'invention concerne des formulations, y compris des formulations liquides et lyophilisées, comprenant une sonde à colorant rouge lointain et un tensioactif non linéaire ou du foamban. L'invention concerne également des méthodes associées pour préparer une formulation de sonde à colorant rouge lointain lyophilisée ainsi que des kits et des produits de diagnostic associés.
Patent CA-3089544-A1 (CA)
Inventor: HOSOKOSHIYAMA HIROSHI
IPC: B65D1/02
Filed: 2018-11-14
Abstract: La présente invention concerne un récipient de délaminage (1), qui est formé par moulage par soufflage d'un ensemble préforme en résine synthétique (40) comportant une préforme interne (60) incorporée au sein d'une préforme externe (50). Le récipient de délaminage (1) est caractérisé en ce qu'il comporte un corps de couche externe (10) pourvu d'une section d'embouchure externe cylindrique (11) et d'une section de corps cylindrique à fond (12) en prolongement de la section d'embouchure externe (11), un corps de couche interne (20) pourvu d'une section d'embouchure interne cylindrique (21) disposée au sein de la section d'embouchure externe (11) et d'une section de stockage déformable réductible en volume (22) stratifiée de manière pelable sur une surface interne de la section de corps (12), et une ouverture d'introduction d'air extérieur (13) destinée à introduire de l'air extérieur entre le corps de couche externe (10) et le corps de couche interne (20), au moins deux nervures épaisses (30) étant formées d'un seul tenant avec la section de stockage (22) de façon à s'étendre chacune le long de l'axe (O) de la section de corps (12) et à rendre l'épaisseur de la section de stockage (22) supérieure à celle des autres sections.
Patent CA-3090759-A1 (CA)
Title: Systems and methods for training generative machine learning models
Inventor: ROLFE JASON T
IPC: G06N20/00
Filed: 2019-02-07
Abstract: Generative and inference machine learning models with discrete-variable latent spaces are provided. Discrete variables may be transformed by a smoothing transformation with overlapping conditional distributions or made natively reparametrizable by definition over a GUMBEL distribution. Models may be trained by sampling from different models in the positive and negative phase and/or sample with different frequency in the positive and negative phase. Machine learning models may be defined over high-dimensional quantum statistical systems near a phase transition to take advantage of long-range correlations. Machine learning models may be defined over graph-representable input spaces and use multiple spanning trees to form latent representations. Machine learning models may be relaxed via continuous proxies to support a greater range of training techniques, such as importance weighting. Example architectures for (discrete) variational autoencoders using such techniques are also provided. Techniques for improving training efficacy and sparsity of variational autoencoders are also provided.
Patent CA-3090877-A1 (CA)
Title: Systeme de surveillance a distance pour la culture cellulaire
Inventor: MARTIN GREGORY ROGER
IPC: C12M1/34
Filed: 2019-02-08
Abstract: L'invention concerne un système de surveillance à distance conçu pour mesurer de manière non invasive une culture cellulaire. Le système comprend une pluralité de couches de culture cellulaire comprenant une chambre de culture cellulaire conçue pour fonctionner en tant que système fermé, ladite au moins une chambre de culture cellulaire possédant au moins une surface à laquelle des cellules adhèrent. Le système comprend en outre au moins une couche de surveillance comprenant une paroi externe entourant une chambre de surveillance de culture cellulaire en couches conçue pour fonctionner en tant que système fermé et possédant au moins une surface à laquelle des cellules adhèrent, ladite au moins une couche de surveillance comprenant au moins une indentation dans la paroi externe. Le système comprend également au moins un module de surveillance disposé dans au moins l'une de ladite au moins une indentation et comprenant au moins l'un d'un dispositif de surveillance de confluence et d'un dispositif de surveillance d'analyte.
Patent CA-3091227-A1 (CA)
Inventor: ULLRICH JR
IPC: A61B17/02
Filed: 2019-02-14
Abstract: L'invention concerne également un système destiné à être utilisé pendant des procédures chirurgicales. Le système comprend un implant et un outil. L'implant combine une cage ajustable modulaire et une cale qui verrouille la cage en position, après que la cage a été ajustée à sa position finale et à sa hauteur finale, in situ. L'outil combine un extenseur et un dispositif d'insertion. L'invention concerne également un procédé associé d'utilisation du système.
Patent CA-3091325-A1 (CA)
Inventor: COMBES SOPHIE
IPC: G07D7/00
Filed: 2020-08-27
Abstract: The invention relates to a module that can be detachably inserted into a casing, the module forming a unitary assembly comprising a smart board incorporating at least: - a document reader comprising at least a camera (4, 5) arranged on a low end of the smart board and pointed toward the outside of the module; and - a lighting device comprising at least a lighting element (7a, 7b, 7c) arranged on the low end of the smart board near the camera, the module comprising a protective case (15) for at least the lighting element and the camera. The invention also relates to an associated casing and terminal.
Patent CA-3092687-A1 (CA)
Inventor: CURRAN MICHAEL A
IPC: C07K16/28
Filed: 2019-03-14
Abstract: La présente invention concerne des anticorps bispécifiques qui se lient à la fois à PD-L1 et à PD-L2, et des procédés d'utilisation de tels anticorps pour traiter des cancers, tels que ceux qui expriment ou surexpriment PD-L1, PD-L2, ou les deux.
Patent CA-3093425-A1 (CA)
Title: Online lending method, and data interaction processing method, device and system
Inventor: ZHANG YI
IPC: G06Q40/02
Filed: 2015-05-29
Abstract: A lending method, and a data interaction processing method, device and system. The lending method comprises: first and second participants respectively submit first and second borrowing requests; after receiving the first and second borrowing requests, a third participant submits an application to open credit certificates to a first funds management server; the first funds management server generates corresponding first and second credit certificates, and respectively freezes corresponding first and second funds of the third participant; according to the first and second credit certificates, a second funds management server grants funds to the first participant which are equal to the first funds, and grants funds to the second participant which are equal to the second funds, the second funds management server setting a repayment time for the granted funds, and monitoring a repayment date of the first participant and the second participant. The present invention reduces the lending risk for a loan initiator.