Patent SG-11201806920S-A (SG)
Title: Modulation hypoxia associated with stroke
Inventor: LE MOAN NATACHA
IPC: A61P9/10
Filed: 2017-02-16
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111110111101110101011111010111110111010111111011010111011111111101111011111 International Bureau ... .... ..Yjd (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/143104 Al 24 August 2017 (24.08.2017) WI P0 I PCT (51) International Patent Classification: (74) Agents: DONAHUE, Brian, A. et al.; Morrison & Foester A61K 38/16 (2006.01) A61P 9/10 (2006.01) LLP, 755 Page Mill Road, Palo Alto, CA 94304-1018 (US). (21) International Application Number: PCT/US2017/018233 (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, 16 February 2017 (16.02.2017) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (26) Publication Language: English KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (30) Priority Data: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 62/296,009 16 February 2016 (16.02.2016) US NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (71) Applicant: OMNIOX, INC. [US/US]; 75 Shoreway Road, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, Suite A, San Carlos, CA 94070-2727 (US). ZA, ZM, ZW. (72) Inventors: LE MOAN, Natacha; C/o Omniox, Inc., 75 (84) Designated States (unless otherwise indicated, for every Shoreway Road, Suite B, San Carlos, CA 94070-2727 kind of regional protection available): ARIPO (BW, GH, (US). KROTOLICA, Ana; C/o Omniox, Inc., 75 Omniox, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Inc., 75 Shoreway Road, Suite B, San Carlos, CA 94070- TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 2727 (US). LEUNG, Philberta; C/o Omniox, Inc., 75 TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Shoreway Road, Suite B, San Carlos, CA 94070-2727 DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (US). CARY, Stephen, P.L.; C/o Omniox, Inc., 75 Shore- LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, way Road, Suite B, San Carlos, CA 94070-2727 (US). [Continued on next page] = = (54) Title: MODULATION HYPDXIA ASSOCIATED WITH STROKE (57) the delivery of oxygen to hypoxic tissue following stroke. H- : The invention provides H-NOX proteins for . NOX proteins extravasate into hypoxic penumbra associated = with stroke and preferentially accumulate for sustained deliv- FIG. 7B ery of oxygen to the hypoxic tissue to ameliorate adverse af- _ _ — fects of stroke related hypoxia. In some embodiments, the H- NOX comprises PEGylated H-NOX and non-PEGylated H- - ES Infarct NOX. D Hypoxic tissue .E 2 5 ..ow p = 0.05 = . (I) 200 E - 1 — ' T M150 . 0 X100 ' — C — = — CC 50 Veh Veh H-NOXP ,-1 .4 ii- Day 1 Day © ,-1 M ii- ,-1 IN ,-1 © ei O WO 2017/143104 Al 1#110H01101DION01010M010111101101010EM0VOIS SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). with sequence listing part of description (Rule 5.2(a)) Published: — with international search report (Art. 21(3))