baber/WOPTO huggingface dataset:
Patent CR-20130464-A (CR)
Title: Inhibidores sustituidos de acetil-coa carboxilasa
Inventor: GRIFFITH DAVID ANDREW
IPC: C07D519/00
Filed: 2013-09-12
Abstract: ESTA INVENCIÓN SE REFIERE A COMPUESTOS PIRAZOLOESPIROCETONA SUSTITUIDOS, QUE ACTÚAN COMO INHIBIDORES DE UNA ACETIL-CoA CARBOXILASA Y SU USO EN EL TRATAMIENTO DE ENFERMEDADES, AFECCIONES O TRASTORNOS MODULADOS POR LA INHIBICIÓN DE UNA ENZIMA (S) ACETIL-CoA CARBOXILASA.-
Patent CR-20180056-A (CR)
Title: Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil] [3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona
Inventor: BROWN ADRIAN ST CLAIR
IPC: C07D401/04
Filed: 2016-06-30
Abstract: La presente descripción se refiere a la sal de fumarato cristalina de (S)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona. La descripción también se refiere a composiciones farmacéuticas que comprenden la sal de fumarato cristalina de (S)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona. La descripción también se refiere a métodos para tratar cánceres que comprenden administrarle a un paciente que lo necesita la sal de fumarato cristalina de (S)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona
Patent CR-20180590-A (CR)
Title: MOLÉCULAS DE ÁCIDO NUCLEICO PARA LA REDUCCIÓN DE ARNm DE PAPD5 O PAPD7 PARA TRATAR LA INFECCIÓN POR HEPATITIS B
Inventor: JAVANBAKHT HASSAN;
IPC: C12Q1/70
Filed: 2017-06-19
Abstract: La presente invención se refiere a un método para identificar un compuesto que previene, alivia y/o inhibe una infección por virus de la hepatitis B (VHB), en donde un compuesto que reduce la expresión y/o actividad de proteína que contiene dominio asociado a PAP 5 (PAPD5) y/o que contiene dominio asociado a PAP 7 (PAPD7) se identifica como un compuesto que previene, alivia y/o inhibe una infección por VHB. La invención también proporciona inhibidores de PAPD5 o PAPD7 para su uso en el tratamiento y/o la prevención de una infección por VHB; así como un preparado combinado que comprende un inhibidor de PAPD5 y un inhibidor de PAPD7 para su uso simultáneo o secuencial en el tratamiento o la prevención de una infección por VHB. La presente invención también comprende una composición farmacéutica para su uso en el tratamiento y/o la prevención de una infección por VHB y un método para supervisar el éxito terapéutico durante el tratamiento de una infección por VHB.
Patent CR-20190584-A (CR)
Title: Detector with reduced fluorescence range noise
Inventor: FUNG TRACY H
IPC: G01N21/64
Filed: 2018-11-30
Abstract: There is set forth herein a device comprising structure defining a detector surface configured for supporting biological or chemical substances, and a sensor array comprising light sensors and circuitry to transmit data signals using photons detected by the light sensors. The device can include one or more features for reducing fluorescence range noise in a detection band of the sensor array.
Patent CR-20210654-A (CR)
Title: Transcatheter heart valve delivery systems and methods
Inventor: BUKIN MICHAEL
IPC: A61F2/24
Filed: 2020-08-05
Abstract: A prosthetic heart valve and delivery device for delivering the prosthetic heart valve to a target implantation site, which reduce contact between the prosthetic heart valve and a delivery sheath through which the delivery device is advanced to the target implantation site, is disclosed. As one example, a prosthetic heart valve may comprise a frame including a first end with a plurality of apices spaced apart from one another around a circumference of the first end and a cover element covering the plurality of apices. The cover element may include a cushioning element or a bio-resorbable element.
Patent EC-SP088626-A (EC)
Title: Compuestos para el tratamiento de trastornos inflamatorios
Inventor: KOZLOWSKI JOSEPH A
IPC: C07D403/06
Filed: 2008-07-16
Abstract: Esta invención se refiere a compuestos de fórmula (I): 						 (I)o una de sus sales, solvatos o isómeros aceptables para uso farmacéutico, que pueden ser útiles para el tratamiento de enfermedades o afecciones mediadas por las MMP, ADAM, TACE, agrecanasa, TNF-a o combinaciones de las mismas.
Patent EC-SP099799-A (EC)
Title: Método y sistema para crear rutas turísticas adaptadas a un sistema de navegación portátil
Inventor: PELOSIO GIORGIO
IPC: G06Q30/06
Filed: 2009-12-14
Abstract: La invención se relaciona a un método y a un sistema para crear senderos turísticos adaptados y a utilizarse con un aparato de navegación portable, mismo que comprendería los siguientes pasos: a) ingreso de parámetros característicos de una estructura capaz de ofrecer servicios turísticos en una base de datos, y dichos parámetros característicos se ingresarían bajo el control de un cuerpo certificado; b) Generando senderos turísticos basados en los mencionados parámetros característicos; c) transfiriendo los mencionados senderos turísticos hacía los mencionados dispositivos de navegación portátiles.
Patent EC-SP951522-A (EC)
Title: Recipiente con caperuza de cierre y procedimiento para el llenado sin burbujas de gas de recipientes
Inventor: BACHTLER WULF
IPC: B65D83/00
Filed: 1995-08-29
Abstract: Una caperuza de cierre para el cierre sin gas de recipientes desplaza durante su colocación sobre el cuello del recipiente una parte del contenido del recipiente y hace posible al mismo tiempo, que el gas encerrado escape a través de uno o de varios orificios antes de que la caperuza de cierre se enclava en la posición de cierre.
Patent GB-1053479-A (GB)
IPC: E05D15/06
Abstract: 1,053,479. Multiple swing door installations; hinges. WILLIAM NEWMAN & SONS Ltd. Sept. 2, 1965 [Nov. 28, 1964], No. 48455/64. Headings E2F and E2M. In a set of six swinging glass doors the two end doors move about fixed pivots while the middle four are coupled together in pairs so that they may be moved in unison to a side of the door-way, with their respective upper and lower pivot axes adjacent. An upper endless chain 33, 33 is attached to the upper pivot 12 of each of one pair of doors via brackets 36 and a spring-operated door closer 13, while a lower chain moves the lower pivot 8, 10 via a longitudinal carriage member 16, the two chains being coupled together to move in unison by sprockets 34 and a manually or electrically rotable shaft 35, Fig. 9 (not shown) at one side of the door way. The closed "inline" doors are stacked in an "out-of-the-way position" on rotation of the shaft and chains to roll each pair of doors on channel-track located wheels 1F, 1F, 30, 30 to the side of the door-way, adjacent the previously inwardly turned fixed door, when the sliding doors are swung to a parallel relation therewith. The pairs of doors may be moved via a single upper and lower chain assembly, in which case each pair of doors is attached to opposite sides thereof. In either case the doors are locked in the "out-of-the-way" position by locks let into the floor.
Patent GB-1053748-A (GB)
IPC: F26B7/00
Abstract: 1,053,748. Screw extrusion presses. INTERNATIONAL BASIC ECONOMY CORPORA TION. April 22. 1964 [April 25, 1963]. No. 16636/64. Addition to 965183. Heading B1D. [Also in Division F4] The invention relates to apparatus substantially as described in the parent Specification but the claims are directed to a method of drying polymeric material in an elongated enclosure through which it is advanced for not more than 60 seconds with gradually increasing temperature and at a pressure such that the liquid in the material is not converted to the vapour state until removal from the enclosure produces flash evaporaion of the liquid to expand and rupture the material.
Patent GB-1226458-A (GB)
IPC: C07C309/65
Filed: 1969-08-08
Abstract: 1,226,458. Nitro-substituted phenylalkanesulphonates and their use as herbicides. DAINIPPON INK KAGAKU KOGYO K.K., and KANESHO K.K. 8 Aug., 1969 [17 Feb., 1969], No. 39909/69. Heading C2C. [Also in Division A5] The invention comprises a substituted 2,4- dinitrophenylalkane sulponate of the formula in which R 1  is an alkyl group and R 2  is a secondary or tertiary butyl group. This compound may be prepared by reacting a substituted 2,4- dinitrophenol of the formula in which R 2  is a secondary or tertiary butyl group with a compound of the formula R 1 -SO 2 -Cl, wherein R 1  is an alkyl group, in the presence of an alkali metal hydroxide or a tertiary amine, the reaction being conducted in an organic solvent. The following compounds are specified: 2,4-dinitro-6-t.-butylphenylmethanesulphonate; 2,4 - dinitro - 6 - sec - butylphenylmethanesulphonate; 2,4 - dinitro - 6 - t.- butylphenylethanesulphonate; 2,4 - dinitro - 6- t. - butylphenylpropanesulphonate; 2,4 - dinitro - 6 - t. - butylphenylisopropanesulphonate; 2,4 - dinitro - 6 - sec - butylphenylethanesulphonate; 2,4 - dinitro - 6 - sec - butylphenylpropanesulphonate; and 2,4 - dinitro - 6 - secbutylphenylisopropanesulphonate.
Patent GB-1228363-A (GB)
IPC: H01H33/75
Filed: 1967-04-28
Abstract: 1,228,363. Making tanks; jointing. A. REYROLLE & CO. Ltd. 26 July, 1968 [28 April, 1967], No. 19821/67. Headings B3A and B3V. [Also in Division H2] An oil-blast circuit-breaker has a circularsection or near-circular section tank 11 made of synthetic resin, the tank having its side wall reinforced externally by a winding or wrapping 25 which is prestressed circumferentially in tension so that the resin of the side wall is prestressed and maintained in compression. The tank may be a gravity moulding of cast resin, such as epoxy resin, containing an inorganic filler such as silica flour. The winding may be a metal wire or a glass-fibre tape or cord. Alternatively, the tank may have a wrapping formed by a metal tube or sleeve shrunk on to the tank wall by a high-energyrate electromagnetic forming process in which the tank with the tube or sleeve is surrounded by an inductor coil through which a bank of capacitors is discharged.
Patent GB-1229187-A (GB)
IPC: B60G17/033
Filed: 1969-07-31
Abstract: 1,229,187. Vehicle spring suspensions. GENERAL MOTORS CORP. 31 July, 1969 [22 Aug., 1968], No. 38389/69. Heading B7D. [Also in Division F2] In a motor vehicle in which a sprung mass is resiliently supported by fluid springs 16, 18, a transducer assembly 44 interconnects the springs 16, 18 and includes a housing or container element 46 and a floating piston element 60 engaged at its ends by rolling lobe diaphragms, the arrangement being such that movement of the piston element from a centred position (Fig. 2) varies the effective crosssectional areas of the diaphragms whereby the assembly is operative to automatically vary the respective static rates of the fluid springs proportionally to changes in the static load distribution on the sprung mass. In one embodiment (as shown), the transducer assembly comprises a floating piston 60 formed of two frustocones, ends 62, 64 of which co-operate with rolling-lobe diaphragms 66, 68. Addition of load at the rear of the vehicle causes pressure in chambers 26, 58 to increase and hence a movement of piston 60 to the left in Fig. 3. The piston moves until the pressure in chambers 26, 58 multiplied by the effective area 69 of the piston end portion 64 is in a 1 : 1 ratio with the pressure in chambers 24, 56 multiplied by the effective area 70 of the piston end portion 62. Under these conditions pitch equilibrium has been restored but the vehicle has departed from a level pitch attitude. Levelling valves 74, 76 operate to admit air to, or exhaust air from, the fluid springs with which they are associated until the piston of each spring is at its design height relative to its associated cylinder, whereby level pitch attitude of the vehicle is restored. The valves may operate simultaneously with, but preferably in sequence with, the transducer assembly. In another embodiment (Fig. 4, not shown), the cross-sectional area of the piston of the front spring is approximately half that of the piston of the rear spring, and the crosssectional dimension ratio of the ends of the floating piston of the transducer assembly is proportional to the ratio of the areas of the pistons. In yet another embodiment (Fig. 5, not shown), the floating piston is cylindrical but adjacent portions of the housing of the transducer assembly are tapered. In an embodiment utilizing a hydropneumatic suspension (Fig. 6, not shown) the springs are filled with hydraulic fluid and the diaphragms of the transducer assembly are replaced by sealed gas-filled bladders. In another embodiment (Fig. 7, not shown), utilizing pneumatic fluid at subatmospheric pressure, the floating piston is formed with opposite ends having confronting tapers.
Patent GB-1230308-A (GB)
IPC: B24D3/14
Filed: 1969-07-22
Abstract: 1,230,308. Abrasive article. CARBORUNDUM CO. Ltd. 1 April, 1970 [22 July, 1969], No. 36804/69. Heading C4V. A ceramic bonded abrasive article is obtained by preparing a mix containing a ceramic bonding agent, abrasive grain, water and sodium silicate, forming a shape from the mix, treating the shape with carbon dioxide to effect chemical reaction with the sodium silicate and firing. The bonding agent may be mixtures of china clays, ball clays, stoneware clays and slip clays, potash and soda feldspars and prepared frits. The mix may contain 0À5-4À0% of sodium silicate. The carbon dioxide treatment may be impregnation while located on a bottom moulding plate.
Patent GB-1231348-A (GB)
IPC: G01F25/00
Filed: 1969-05-29
Abstract: 1,231,348. Measuring fluid-flow. M. H. GROVE & J. M. E. GROVE [trading as M. & J. DEVELOPMENT CO.], May 29, 1969 [June 10, 1968], No.27168/69. Heading G1R. In a meter proving method or system comprising a metering loop 19 having inlet and discharge ends 31, 23 and adapted to receive a flow propelled sphere, an interchange section 21 connecting the inlet and discharge ends 31, 23 and formed between separately controllable hydraulically operated valves V1, V2, a retractable detent 114 located between the valve V2 and the inlet 31, a separate controllable power operated means is provided to operate the valves V1, V2 and detent 114 and has an automatic cycle of operations such that the sphere is positioned between the valves V1, V2, valve V2 is first opened to enable the sphere to pass to a position abutting detent 114, the valve V1 is checked for leaks, the valve V2 closed detent 114 retracted and the sphere enters the loop 19 and returns to the interchange 21 through valve V1.
Patent GB-1233369-A (GB)
IPC: B64C27/32
Filed: 1967-10-04
Abstract: 1,233,369. Helicopter rotors. MINISTER OF TECHNOLOGY. 13 Sept., 1968 [4 Oct., 1967], No. 45110/67. Heading B7W. [Also in Division F2] A helicopter rotor assembly has at least one blade comprising a hollow apertured shell 17, Fig. 4, divided into two ducts 19, 20 by a partition 18 so as to form two fluid discharge apertures, preferably of different widths, 21, 22, and carried by a rotatable head member 1, Fig. 1, mounted on fixed structure so that air may be supplied to and discharged from the blade for lift purposes. At the root section 3 of a blade the two ducts 19, 20 of the blade open into a transfer port divided by a baffle 6. The two ducts 7, 8 thus formed communicate spanwise with the blade ducts 19, 20 and downwardly with segmental air supply ports 12 in the fixed structure. The segmental ports are contained by inner wall 2, outer wall 9, and by radial walls 11, and are divided into ducts 13, 14 which communicate with the blade ducts 7, 8. The ducts 12 have a common air supply, not shown, and in each duct is an L-shaped member 16 which may be moved up or down to obstruct the air flow through ducts 13 and 14, thereby altering the air discharge through aperture divisions 21, 22 and being capable of terminating air flow through duct 13 while still providing regulation of the air flow through duct 14. The members 16 may be connected to a control system to provide collective or cyclic variations in air flow. More than one aperture may be used, though all should be in one surface of the blade, and should discharge in a common direction; the apertures may also be divided into spanwise sections each with its own air supply.
Patent GB-1234412-A (GB)
IPC: F23Q2/28
Filed: 1968-08-05
Abstract: 1,234,412. Gas-fuelled lighters. MANSEI KOGYO K.K. 5 Aug., 1968 [3 Aug., 1967; 26 Aug., 1967], No. 37205/68. Heading F4F. In a gas-fuelled smokers' lighter the gas, which issues from the valve nozzle 3a of a valve 3 on opening of a hinged cap 8 at the top of the lighter, is ignited by a spark passing between electrodes 23 and 24 which are in electrical connection with a piezo-electric assembly 17 energized by a spring-loaded striker 20 which is accommodated in a sheath 19, a reciprocable finger-piece 25 being depressible to stress a spring 28 interposed between the finger-piece 25 and the striker 20 so that striker 20 is driven into impact with assembly 17. A valve control member 14 engages a telescopic twoport cylinder 12 situated laterally of valve nozzle 3a and one end of the cylinder is pivoted to the cap 8 on a bracket 9 and the other end is slidably mounted in a pocket 5a<SP>1</SP> in arm 5a of a U-shaped support 5 for electrodes 23 and 24, which support 5 is fitted above a fuel reservoir 2. The piezo-electric assembly 17 is located at the base of the lighter and the striker 20 is normally held in spaced relationship above the assembly 17 by a catch 29 which projects through an aperture 19c in the sheath 19. The finger-piece 25 has a stop 25a positioned to limit travel thereof away from assembly 17 by abutment of the stop against the base 5c of electrode support 5. In operation of the lighter (Fig. 3, not shown), the cap 8 is swung into its open position thereby telescoping cylinder 12 and simultaneously unstressing a leaf spring 15 fixed to control member 14, thereby allowing the valve 3 to open and gas to flow between electrodes 23 and 24. As the cap 8 is swung open, fingerpiece 25 is exposed and to give an igniting spark finger-piece 25 is depressed and spring 28 is thereby stressed until catch 29 is disengaged from the striker 20 by the downward movement of the finger-piece 25, whereupon the striker 20 is spring driven into impact with the assembly 17. A spring 27 returns the striker 20 to its inoperative position on cessation of the depressive force upon the finger-piece 25. In a modification (Figs. 4 and 5, not shown), the striker is provided with a transverse pin and the sheath, which may be of insulating synthetic resin material, has a pair of diametrically opposed L-shaped slots, each having a leg extending circumferentially of the sheath from the upper end of the other leg which extends longitudinally of the sheath and the circumferential legs are engaged by opposite ends of the pin. When the finger-piece is depressed parallelogram shaped apertures in the finger-piece, into which apertures the pin projects, impart a rotary movement to the striker until it is spring-driven down the sheath with the pin ends in the longitudinal legs of the L-shaped slots.
Patent GB-1250321-A (GB)
IPC: E03D9/05
Filed: 1968-11-27
Abstract: 1,250,321. Ventilating toilets. A. C. PALEY. 27 Nov., 1968 [7 Dec., 1967], No. 56296/ 68. Heading E1C. A ventilator for a W.C. comprises a substantially circular tube 2 which may be in two parts or may in fact be horse shoe in plan with holes 4 on its underside, which tube fits between a toilet seat and the bowl. An exhaust pipe 3 leads from the tube to a fan, used for extracting the obnoxious gases. In a second embodiment the ventilation comprises two U-section circular members which overlap and are connected to an exhaust pipe (Fig. 5 not shown).
Patent GB-1251332-A (GB)
IPC: G01P13/02
Filed: 1967-11-12
Abstract: 1,251,332. Wind direction and force indicators; spring-biased assemblies. FERRARIS DEVELOPMENT & ENG. CO. Ltd. 11 Feb., 1969 [12 Nov., 1967; 1 Aug., 1968], Nos. 46682/67 and 36749/68. Heading F2S. [Also in Division G1] In an assembly, such as for a windspeed or direction indicating device, a hollow cylindrical member 71, secured to a shaft 15 provided with a counterweight 18, is mounted in an elastomeric bush 14 and is normally held in the vertical position by a tension spring 19 secured at one end to the lower end of the shaft 15 and at the other end to a threaded member 21 adjustably mounted in a threaded sleeve 49 fixed to a easing 13. Movement of the member 17 from the vertical due to the speed and direction of the wind, is transmitted via three fluid filled bellows 32 and flexible tubes 40 to three vertically disposed bellows 33 of a display unit 12. The bellows 33 are fixed at one end to an annular plate 34 fixed to a base plate 31 and at the other end to a ring 35 forming the outer ring of a gimbals system the inner ring 36 of which is mounted on a fixed ring 29. The ring 35 has a limb 37 of an L-shaped member fixed thereto, the other arm, 38 of which L-shaped member carries a closed ended tube 39 in which is slidably located a ball shaped end 41 of a pointer 41 to which is attached a tension member 42, held in tension by a radially disposed blade spring 43 adjustable by a number of set screws 45. The pointer 26 is supported for universal movement by an elastomeric diaphragm 46 the periphery of which is held by a plate 48 against an end face 47 in a recess in the fixed ring 29. The movement of the member 17 effects, through the bellows 32, 33a, corresponding movement of the pointer 26 to indicate wind speed on rings 27 and direction by radial lines 28. The initial setting, of the apparatus is effected by clamping rod 5' between jaws 53 actuated by inflatable bags 56.
Patent GB-1264442-A (GB)
IPC: G06K7/08
Filed: 1970-11-10
Abstract: 1,264,442. Record cards. INTERNATIONAL BUSINESS MACHINES CORP. 10 Nov., 1970 [29 Dec., 1969], No.53315/70. Heading G4M. A card 10 has fixed low-density data recorded in the form of a pattern of discrete magnetizable areas 12 and variable high density data additionally recorded by means of a head 14 having a skewed gap 16. Both sets of data on the card may be read by a similarly skewed-gap head if the bits 12 are pre-biased. Alternatively, the fixed data may be read by a head having a gap aligned with bits 12. A further possibility is to apply a magnetic field to transfer both sets of data to a magnetic tape which is then read.
Patent GB-1288490-A (GB)
IPC: G09F3/04
Filed: 1970-02-25
Abstract: 1288490 Labels UNISTO AG 25 Feb 1970 [27 Feb 1969] 9102/70 Heading B8F A tag for attaching to nets comprises a resilient plastic sheet 2 glued to the rear of an indicia bearing plate 1 and having strips 3 punched therefrom which are formed with barbs 4 and have their free ends 5 bent over towards the plate. The strips are reinforced by a central ridge 6. The tag is attached to a net by the strips 3 and barbs engaging the meshes of the net.