baber/WOPTO huggingface dataset:
Patent CA-2423474-A1 (CA)
Inventor: BURK ROBERT M
IPC: A61K31/5575
Filed: 2001-08-22
Abstract: La présente invention concerne l'utilisation d'acide cyclopentane heptan(ène)oïque, de 2-thiocarbamoyloxy et de carbamoyloxy en tant qu'agents thérapeutiques, par ex. en tant qu'hypotenseurs oculaires. Les composés utilisés selon la présente invention sont représentés par la formule (I) dans laquelle les segments ondulés indiquent soit la configuration alpha (.alpha.), soit la configuration bêta (.beta.) ; la liaison en tirets représente une double liaison ou une liaison simple; Z représente O ou S ; Ar est choisi dans le groupe constitué par des radicaux aryle ou hétéroaryle ayant 4 à 10 atomes de carbone et des dérivés substitués desdits radicaux aryle et hétéroaryle ; n vaut 0 ou un nombre entier de 1 à 4; x et y valent 1 ou 0, à condition que lorsque x vaut 1, y vaille 0 et que lorsque x vaut 0, y vaille 1; R?1¿ représente hydrogène ou un radical alkyle inférieur ou un radical alkyle inférieur substitué ayant jusqu'à six atomes de carbone; X est choisi dans le groupe constitué par -OR?1¿ et -N(R?1¿)¿2?; Y représente =O ou deux radicaux hydrogène. La présente invention concerne également les 9 et / ou 11 esters de ces composés et / ou les sels pharmaceutiquement acceptables desdits composés et / ou esters.
Patent CA-2424472-A1 (CA)
Inventor: PROCTOR KENNETH W
IPC: G01D5/20
Filed: 2003-04-04
Abstract: Une sonde qui permet de détecter le mouvement d'un corps magnétique comprend une pièce polaire magnétisable, un circuit électrique en boucle fermée présentant une première extrémité enroulée autour de la pièce polaire et formant un enroulement couplé par induction à la pièce polaire. Ce montage fait que le mouvement d'un corps magnétique par rapport à la pièce polaire induit un courant dans le circuit en boucle fermée et d'une seconde extrémité, éloignée de la pièce polaire, qui forme un enroulement primaire de transformateur. Un enroulement secondaire de transformateur est inductivement couplé à l'enroulement primaire et se termine par une résistance de charge et des moyens permettant de mesurer le signal de sortie du bobinage secondaire. Les enroulements primaire et secondaire forment un transformateur, de sorte qu'un courant dans l'enroulement primaire induit une tension aux bornes de l'enroulement secondaire. Une ou plusieurs spires de mise en court-circuit d'un conducteur sont inductivement couplées aux enroulements primaire et secondaire.
Patent CA-2426952-A1 (CA)
Title: Small molecule compositions for binding to hsp90
Inventor: ROSEN NEAL
IPC: A61P43/00
Filed: 2001-11-01
Abstract: Structural differences in binding pockets of members of the HSP90 family can be exploited to achieve differential degradation of kinases and other signaling proteins through the use of designed small molecules which interact with the N-terminal binding pocket with an affinity which is greater than ADP and different from the ansamycin antibiotics for at least one species of the HSP90 family.Moreover, these small molecules can be designed to be soluble in aqueous media, thus providing a further advantage over the use of ansamycin antibiotics. Pharmaceutical compositions can be formulated containing a pharmaceutically acceptable carrier and a molecule that includes a binding moiety which binds to the N-terminal pocket of at least one member of the HSP90 family of proteins. Such binding moieties were found to have antiproliferative activity against tumor cells which are dependent on proteins requiring chaperones of the HSP90 family for their function. Different chemical species have different activity, however, allowing the selection of, for example Her2 degradation without degradation of Raf kinase. Thus, the binding moieties possess an inherent targeting capacity. In addition, the small molecules can be linked to targeting moieties to provide targeting of the activity to specific classes ofcells. Thus, the invention further provides a method for treatment of diseases, including cancers, by administration of these compositions. Dimeric forms of the binding moieties may also be employed.
Patent CA-2431085-A1 (CA)
Title: Manufacturing solvent-free solid paint
Inventor: MCKAY GARRY MICHAEL
IPC: B01F23/00
Filed: 2001-12-12
Abstract: A method and apparatus for manufacturing small batches of solid paint is disclosed. The method includes a first step of providing a component of the solid paint as a liquid in a heated mixing container (15) that has a base (4 1) and sides (43) and includes a stirrer (23) for stirring the contents of the container. The next step of the method incudes controlling heating stirring of the contents of the container and progressively adding other components of t he solid paint as solids to the container. The liquid acts as a heat transfer medium that transfers heat from the heated container and from the stirrer to  the solids. The mix is heated to a temperature of the solid paint and forms a melt that is a uniform liquid. The final step in the method includes discharging the melt from the container and allowing the melt to cool and fo rm the solid paint.
Patent CA-2431238-A1 (CA)
Title: Sofc stack with thermal compression
Inventor: PERRY MARTIN
IPC: H01M8/04
Filed: 2002-03-27
Abstract: tA solid oxide fuel cell stack includes a thermally responsive compression element. The compression element extends between the top and bottom plates of the stack and has an overall coefficient of thermal expansion which is substantially the same or less than the composite coefficient of thermal expansion of the stack itself. The compression element may be elongated and include a lower rod, an upper sleeve and an intermediate expansion member which are concentrically arranged. The expansion member bears on shoulders formed on the lower rod and upper sleeve to provide a compressive force at elevated temperatures, if the expansion member has a higher coefficient of thermal expansion than the lower rod and upper sleeve.
Patent CA-2432705-A1 (CA)
Inventor: OMELYANCHOUK ALEXANDER N
IPC: H01L39/22
Filed: 2001-12-21
Abstract: In accordance with the present invention, a superconducting phase shift devide is presented. The phase shift device can introduce a phase shift between the phases of the order parameters of the devic'e tow terminals. The two terminal can be coupled through an anisotropic superconductor with angles sides, or through two anisotropic superconductors with misaligned phases, or through a ferromagnet in the junction area. The phase shift device can be used in superconducting quantum computing circuitry. A method of fabricating the phase shift device with a technology different from fabrication technology of conventional superconducting materiasl is described. A method for fabricating a phase shifter chip including an array of phase shift devices is described.
Patent CA-2433540-A1 (CA)
Title: Use of a zwitterionic surfactant together with an anionic ether-containing surfactant as a drag-reducing agent
Inventor: OSKARSSON HANS
IPC: C09K23/00
Filed: 2002-01-15
Abstract: The present invention relates to the use of a zwitterionic surfactant in combination with an ether sulphate or ether carboxylate surfactant in a water-based system as a drag-reducing agent. The combination has besides a high drag-reducing effect also a low sensitivity to hard water.
Patent CA-2433856-A1 (CA)
Inventor: FRANCOIS IRENE
IPC: C07H15/207
Filed: 2001-05-11
Abstract: Compounds having a mimetic or antagonistic property of an inositol phosphoglycan, and the uses of these compounds are disclosed, together with the use, e.g. to treat a condition ameliorated by administration of an IPG  second messenger or an IPG antagonist thereof. Preferred compounds of the invention are based on the substituted cyclitols, such as the chiro-inositol derivative pinitol (3-O-methyl-chiro-inositol).
Patent CA-2439744-A1 (CA)
Inventor: MACDOUGALL BARRY
IPC: C25B9/17
Filed: 2003-09-03
Abstract: An electrochemical cell design is disclosed for the particular application of the electrochemical treatment of contaminants in water. The cell is designed to allow the treatment of low concentrations of contaminants in low conductivity water efficiently, and to be simple to fabricate. The design incorporates tapered inlet and outlet fluid flow manifolds so that the cell pressure drop will be almost entirely due to fluid contacting the electrodes, thus maximising the effective use of the system pump power. A short anode to cathode distance and thin working electrodes are used to minimise resistive electrical power losses. The parallel stacked arrangement of the electrodes and the smooth inlet and outlet designs leads to relatively even distributions of current density and mass transfer resulting in maximal utilisation of the entire active electrode surface area. The electrodes are connected internally in parallel in monopolar stack modules, and the modules are then connected externally in series, with insulating baffles to minimise current by-pass problems. This provides a simple cell construction (a minimum number of simple insulating baffles) while still simplifying the cell wiring and reducing the cell current demand (allowing tighter wiring to be used).
Patent CA-2440404-A1 (CA)
Title: Refractory plug or brick for injecting gas into molten metal
Inventor: WILLOUGHBY CRAIG
IPC: B22D11/10
Filed: 2002-03-19
Abstract: The invention concerns a plug or brick (1) for injecting gas into molten metal through a molten metal-contacting surface (11) comprising (i) a porous refractory body (2) substantially surrounded by a substantially non-porous body (9) except at the molten metal-contacting surface (11); and (ii) gas conducting means (3, 5) for conveying the gas from a gas source to the porous body (2). The plug or brick is characterized in that the non-porous body (11) is made of refractory material and in that the porous and non-porous bodies (2, 11) have been co-pressed. This plug or brick can be used to inject efficiently and reliably small bubbles into a molten metal bath.
Patent CA-2442775-A1 (CA)
Title: New polynucleotides and polypeptides of the ifn alpha-21 gene
Inventor: ESCARY JEAN-LOUIS
IPC: C12Q1/68
Filed: 2002-03-29
Abstract: The present invention relates to new polynucleotides derived from the nucleotide sequence of the IFN.alpha.-21 gene comprising new SNPs, and new polypeptides derived from the natural wild-type IFN.alpha.-21 protein comprising at least one mutation caused by at least one SNP of the invention as well as their therapeutic uses.
Patent CA-2443182-A1 (CA)
Title: Compositions containing a cosmetically active organic acid and a legume product
Inventor: LIU JUE-CHEN
IPC: A61K8/97
Filed: 2003-09-29
Abstract: The present invention features a cleansing composition containing (i) a surfactant, (ii) a legume product, and (iii) a cosmetically active organic acid or a cosmetically acceptable salt or ester thereof, and the use thereof in cleansing the skin.
Patent CA-2443480-A1 (CA)
Inventor: CAVENAGH EDWARD J
IPC: D03D25/00
Filed: 2003-09-30
Abstract: A support column for supporting, for example a mine shaft, is formed by providing a tubular woven polyethylene fabric form for receiving and containing a heated settable filler material while it sets. The form includes a tubular wall defined by a helically wrapped strip and two circular end panels all stitched together with a filler opening in one end panel and in the tubular wall. The flexible woven fabric is laminated on its inside surface with a metal foil layer.
Patent CA-2443746-A1 (CA)
Inventor: CRISTOFALO MICHAEL
IPC: G06Q30/02
Filed: 2001-04-17
Abstract: A system and process for targeting programming (including, but not limited to, advertising) to users by utilizing media object (105) to provide specific content to a user, or groups of users, based upon user profiling information (106) is described. More specificall, the system and method provides for the generation of media object based content, formatting and transmitting the content, and receiving and presenting the content to a user based upon user profile information. The system includes a media object creator (108), which creates media objects utilized i programming signal, a transmitting system for transmitting the media objects, a receiving system (104) connected to a presentation device (112) for receiving and presenting the media objects and a user profiling system which determines which media objects a user is to received based upon user profile information.
Patent CA-2444929-A1 (CA)
Title: A process for removing aluminosilicate material from a substrate, and related compositions
Inventor: KOOL LAWRENCE B
IPC: F01D25/12
Filed: 2003-10-09
Abstract: A process for removing aluminosilicate-based material (e.g., "CMAS") from a substrate is described. The material is treated with an aqueous composition containing at least one acid having the formula H x AF6, in which A is Si, Ge, Ti, Zr, Al, and Ga; and x is 1-6. Treatment of the substrate is often carried out by immersion in an aqueous bath. The process is also very effective for removing CMAS-type material from cavities in the substrate; e.g., cooling holes in a gas turbine component.      Related compositions are also described.
Patent CA-2447429-A1 (CA)
Title: Hand-held, heat sink cryoprobe, system for heat extraction thereof, and method therefore
Inventor: HAAS MICHAEL J
IPC: F25B21/02
Filed: 2002-04-24
Abstract: A cryoprobe system utilizing a monolithic, insulated, hand-held thermal mass (1) having an exposed tip (3) for cryosurgical applications and the like, as well as a heat extraction base (4) configured to interface with the thermal mass to quickly and efficiently reduce the heat of the thermal mass to cryogenic temperatures. The heat extraction base of the preferred embodiment of the present invention is configured to interface with the tip (17) of the thermal mass, such that the tip plugs in securely to the base, to permit an efficient thermal transfer of heat from the thermal mass through the base via a heat exchange system communicating with the base which employs a low temperature cryo-refrigeration unit (20). Also claimed is the method of cryosurgery employing the device(s) of the present invention.
Patent CA-2448442-A1 (CA)
Title: Turbidimetre optique a lentille tubulaire
Inventor: KING KARL
IPC: G01N21/53
Filed: 2002-05-21
Abstract: L'invention porte sur un appareil de mesure de la turbidité d'un liquide comprenant une lentille tubulaire d'un matériau transparent présentant une ouverture recevant le liquide. Un premier et un deuxième émetteur de lumière contigus à la lentille tubulaire produisent deux faisceaux lumineux divergeant sous des angles prédéfinis et frappant la lentille tubulaire qui réfracte lesdits faisceaux dans l'ouverture pour constituer des faisceaux collimatés séparés. Un premier détecteur de lumière contigus à la lentille tubulaire est diamétralement opposé au premier émetteur de lumière, et un deuxième détecteur de lumière est diamétralement opposé au deuxième émetteur de lumière. Chacun de ces détecteurs produit un signal indiquant l'intensité de la lumière reçue de l'intérieur de la lentille tubulaire et on traite les signaux pour en tirer des mesures de turbidité.
Patent CA-2450074-A1 (CA)
Title: Acylic piperazine and piperidine derivatives which are useful for treating neuronal damage
Inventor: BOTFIELD MARTYN
IPC: C07D295/185
Filed: 2002-06-13
Abstract: The present invention relates to acyclic piperazine and piperidine derivatives, which are especially useful for treating or preventing neuronal damage, particularly damage associated with neurological diseases. These compounds are also useful for stimulating nerve growth. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage or for stimulating nerve growth.
Patent CA-2450661-A1 (CA)
Title: Preparation of flumethasone and its 17-carboxyl androsten analogue
Inventor: VILLAX IVAN
IPC: C07J5/00
Filed: 2002-06-11
Abstract: Process for preparing flumethasone (6.alpha.,9.alpha.-difluoro-11(3,17.alpha.,21-trihydroxy-16.alpha.-methyl-pregna-1,4-diene-3,20-dione), flumethasone 21-acetate or its 17-carboxyl androsten analogue of the formula:      which process comprises (a) reacting a compound of formula (II)   with benzoyl chloride to form a 3-enolic ester of the formula (IIIa):      b) reacting the enol benzoate (IIIa) with an electrophilic fluorination agent to introduce fluorine in the C6- position to form a compound of formula (IIIb):      (c) deprotecting the compound (IIIb) at C3 to form a compound of formula (IV):      (d) fluorinating the 9,11-epoxy group of compound IV by reacting it with hydrofluoric acid to yield flumethasone 21-acetate; and optionally (e) hydrolysing the flumethasone 21-acetate, in the presence or absence of an oxidising agent, to yield compound (I) or flumethasone, respectively.
Patent CA-2451087-A1 (CA)
Title: Use of histamine receptor h3 gene in controlling body weight or food intake
Inventor: TAKAHASHI KAZUHIKO
IPC: A61K48/00
Filed: 2002-06-28
Abstract: To clarify the function of a histamine receptor H3 protein in vivo, it is attempted to construct a nonhuman higher animal in which the expression of a histamine receptor H3 gene is artificially regulated. As a result, it is found out that this nonhuman higher animal shows increased body weight, food intake, blood insulin level or blood leptin level compared with a control. Thus, it is found out that disorders in the histamine receptor H3 protein relate to diseases characterized by changes in body weight or food intake, which makes it possible to screening drugs for treating or preventing these diseases and examine the diseases.
Patent CA-2452552-A1 (CA)
Title: Electrode arrangement
Inventor: BLUM STEPHAN RUDIGER
IPC: H01M8/243
Filed: 2002-07-04
Abstract: In order to increase the output of a fuel cell, the fuel cell has an electrode arrangement comprising a number of series-connected electrode bundles (1-6), each consisting of a number of parallelly connected electrodes (7) and each being electrically connected and captive at the ends.
Patent CA-2460084-A1 (CA)
Title: Post-treatment of laminated nonwoven cellulosic fiber webs
Inventor: WADSWORTH LARRY C
IPC: D04H13/00
Filed: 1994-07-22
Abstract: A method for post-treating a laminate precursor nonwoven web which includes layers of thermoplastic man-made fibers and at least one layer of cellulose-based staple natural fibers, including consolidating the web longitudinally and thereby reducing the maximum pore size measure of the web. The presursor web and the resultant consolidated nonwoven web are also disclosed, as is utilization of the product web in medical uses.
Patent CA-2460285-A1 (CA)
Inventor: KUMAR SURINDER
IPC: H03K5/13
Filed: 2004-03-09
Abstract: The present invention provides a method to improve the frequency resolution and phase noise of a synthesized RF signal. It also results in the superior characteristics of instantaneous frequency changeability, wide frequency setting ability, and fully digital ASIC implementation ability. The synthesized RF signal is generated from a higher reference frequency using a variable pulse stretching technique. The amount of the pulse stretch in each cycle is controlled by a phase increment value and is implemented using programmable delay lines. Pulse stretching is extended beyond one cycle by pulse swallowing, allowing the generation of an RF signal from DC up to the input reference clock signal frequency.
Patent CA-2461156-A1 (CA)
Title: Software transparent system and method for peer-to-peer message routing
Inventor: SOLOMON GARY
IPC: G06F13/40
Filed: 2002-11-14
Abstract: Disclosed are a system and method of transmitting data in a processing platform. A switch may comprise an upstream port coupled to a root device to communicate with a processing system. The switch may also comprise a plurality of downstream ports where each downstream port is adapted to be coupled to a device. Data may be transmitted between downstream ports based upon routing information for transmitting data from the upstream port to each of the downstream ports.
Patent CA-2463524-A1 (CA)
Title: Improving the hydrophilicity of water repellent soil
Inventor: BIALLY PAUL THOMAS
IPC: C09K17/14
Filed: 2002-10-08
Abstract: Water repellent soil is treated with low concentrations of a blend of alkyl polyglycoside and EO/PO block copolymer in a weight ratio range of from 6:1 to 0.5:1 of glycoside to block copolymer in order to rapidly increase the wetti ng rate of the water repellent soil.
Patent CA-2464283-A1 (CA)
Inventor: CUNDLIFFE VIVA MARIE
IPC: B01D53/76
Filed: 2004-05-14
Abstract: In a system of high temperature Carbon Dioxide waste stream removal, it is known to have a two to three jacket sodium-containing wall around the fusion reaction or reactor, and the temperature of the jackets will each be maintained by the application of Carbon Dioxide as a temperature flux modulator. The first jacket will abstract heat from the fusion reaction by circulation and will transfer the heat to an ancillary rear where temperatures of 1700 degrees Celsius or higher are made to contact the Carbon Dioxide waste gas and reform it into carbon black powder and monatomic Oxygen. The second two layers will provide circulation of heat fluxes and naturally occurring heat away from the reactor, and both of these layers will be temperature controlled by Carbon Dioxide. The system includes an electrostatic overload safety mechanism for the fusion reaction provided by any number of high temperature rods that are positioned around the fusion reaction and will collect unstable ar undesired electrostatic charge overloads occurring from or near the fusion reaction, which can be used directly, or through adequate power conditioning or disposal. A small version of this system, with modifications, is proposed for larger mobile Carbon Dioxide sources.
Patent CA-2465215-A1 (CA)
Title: Swing bolt lock with improved tamper resistance and method of operation
Inventor: GARTNER KLAUS W
IPC: E05B17/20
Filed: 2003-01-07
Abstract: The locking bolt (40) of a swing bolt lock (10) has an elongated opening (42) that fits on a shaft in the lock's housing. The shaft has a compression spring (68) that biases the bolt toward one side of the shaft. In normal operation, the compression spring urges the bolt such that the shaft is at one end of the elongated opening. There, the swing bolt pivots about the shaft to unlock the lock. When a person tries to force the lock, the elongated opening of the bolt moves against spring bias along the shaft. In one embodiment, flat surfaces in the opening and on the shaft engage each other and a notch on the outside surface of the bolt engages a stationary safety key. This prevents the bolt from applying sufficient force to break weaker parts within the lock mechanism and force the lock open.
Patent CA-2465390-A1 (CA)
Title: Improvement to a method and instrument for inspection of the bond between a honeycomb core and skin
Inventor: LESPINET OLIVIER
IPC: G01N21/88
Filed: 2004-04-28
Abstract: The method for inspection of the bond between a honeycomb core and a skin comprises the following operations: use of a light source (15) to illuminate a so-called illuminated area (17) on the free surface (4) of the honeycomb (1), - automatically detect emerging light (21) from the cells (5) in a so-called observed area (22) also at said free surface (4), - automatically detect openings (6) of the cells (5) in a so-called photographed area (32) also at said free surface (4).      Said instrument for inspection of the bond between a honeycomb core and a skin is specially designed to implement the inspection method described above.      Figure 5.