baber/WOPTO huggingface dataset:
Patent TW-202321302-A (TW)
Inventor: WANG ZHUOZHI
IPC: C07K16/24
Filed: 2018-05-18
Abstract: The present invention provides CTLA-4 monoclonal antibodies, particularly humanized monoclonal antibodies specifically binding to CTLA-4 with high affinity. The present invention also provides functional monoclonal antibodies cross-reactive to CTLA-4 of human, cynomolgus monkey and mouse. The present invention further provides amino acid sequences of the antibodies of the invention, cloning or expression vectors, host cells and methods for expressing or isolating the antibodies. The epitopes of the antibodies are identified. Therapeutic compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating cancers and other diseases with anti-CTLA-4 antibodies.
Patent TW-202337123-A (TW)
Title: Power conversion system
Inventor: IZUMOTO NAOTO
IPC: H02M3/335
Filed: 2023-02-23
Abstract: The problem of the present invention is to performing soft switching more reliably. In the present invention, a control device (3) shifts to control in a second period by turning off a second semiconductor switching element (Q6) once, in a first period, an excitation current (iLm) starts to flow in the negative direction and discharging of a first parasitic capacitor (C5) between both ends of a first semiconductor switching element (Q5) and a second parasitic capacitor (C6) between both ends of the second semiconductor switching element (Q6) has concluded. A second control unit (5) controls the first semiconductor switching element (Q5) so that the individual timings at which the first semiconductor switching element (Q5) is turned on and off will be when discharging of the first parasitic capacitor (C5) ends. The second control unit (5) controls the second semiconductor switching element (Q6) so that the timing at which the second semiconductor switching element (Q6) is turned on and off is when discharging of the second parasitic capacitor (C6) ends.
Patent TW-202337165-A (TW)
Title: Method for synchronizing clock state and communication device
Inventor: ZANG XIN
IPC: H04L7/02
Filed: 2023-03-14
Abstract: This application discloses a clock status synchronization method and a communications apparatus. In the method, a first access network device determines a clock status of the first access network device, and sends a clock status message to a first network device or a target terminal. The first network device and/or the target terminal, sends a timing service request to a second network device according to the clock status message, to request to acquire an access network device that provides a timing service for the first network device and/or the target terminal. The second network device determines an access network device that provides the time service for the first network device and/or the target terminal, and sends the time service indication information to the determined access network device, so as to instruct the access network device to provide the time service for the first network device and/or the target terminal. According to the foregoing method, a problem of how to ensure that the first network device and the target terminal can obtain the time service when the clock of the access network device is faulty can be resolved, thereby implementing time synchronization with the TSN system based on time synchronization of the mobile communications system.
Patent TW-202325265-A (TW)
Title: Intradialytic use of sodium nitrite
Inventor: SHERMAN CRAIG
IPC: A61K31/04
Filed: 2018-03-07
Abstract: Provided herein are methods for maintaining physiological levels of nitrite in a subject undergoing hemodialysis. Also provided herein are methods of administering pharmaceutically acceptable sodium nitrite to a subject undergoing hemodialysis.
Patent UA-36617-A (UA)
Title: plate for the osteosynthesis of processes of the shin-bone
Filed: 2000-01-13
Abstract: The invention relates to mediacl equipment and can be used in traumatology and orthopedy for increasing of stability of fixing of fractures of processes of the shin-bone. The plate for the osteosynthesis of processes of the shin-bone contains on-bone plate with apertures and screws, has additional compressing plate with apertures and the screw for a compression, and the on-bone plate is made with forked blade on the end.
Patent UA-36635-A (UA)
Title: Pyrolysis apparatus for utilization of organic waste
Filed: 2000-01-18
Abstract: Pyrolysis apparatus for utilization of organic wastes has sealed reactor with external heating, axle with rotor, mechanical grabbles, units for loading and unloading, branch pipe for vapor-gas mix outlet. The rotor is arranged of separate sections as squirrel case, its long ribs are equipped with springy elements placed in chess order in perimeter of section and installed with possibility of springy contact with the inner surface of the reactor. The invention relates to installations for thermal method of utilization of organic wastes and can be used in municipal engineering, medicine, chemical, oil-chemical and other branches of industry for regeneration of hydrocarbons to liquid, gaseous and solid fuels.
Patent UA-47038-A (UA)
Inventor: FEDORCHUK YELYZAVETA PETRIVNA
Filed: 2001-06-26
Abstract: The method for re-creation of the craniotype of the unknown person consists in estimating the X-ray osteometric parameters of the bone remains of the dead man. Using the contact X-ray film several parameters such as whole arc length of the hyoid bone, the greater and lesser radii of the hyoid curvature, and the distance between the osseous and cartilaginous ends of the greater horns are measured. Then the transverse-longitudinal index of the hyoid bone is calculated.
Patent UA-55768-A (UA)
Title: Thermostatic condensate hot-well
Inventor: PYLYPCHAK VITALII IVANOVYCH
Filed: 2002-06-11
Abstract: Thermostatic condensate remover has housing with inlet and outlet channels, between those there is installed the saddle of the valve, cover, thermo-power drive and connected to it shutoff body. Thermo-power drive is made as a screw cylindrical spring of material having effect of “shape memory”. Spring is put on the rod of shutoff body – plate of the valve, and is placed between the plate and the base of controlled rod, in the closed opening of which there is centered the rod of shutoff body. At that, the controlled rod is installed in the cover, this one is made as a cup with throw on nut.
Patent UA-55823-A (UA)
Title: Resilient guide part
Inventor: BALABANOV IHOR VALERIIOVYCH
Filed: 2002-07-03
Abstract: The proposed resilient guide part is made as a square plate with cut-outs producing crosspieces between the center and edges of the plate, which crosspieces are arranged at an angle of 90 degrees. Each of the crosspieces contains a central section and two side sections. The stiffness of the central section exceeds significantly the stiffness of the side sections.
Patent UA-60828-A (UA)
Title: Method for production a wearproof coating
Inventor: MYKHAILOV ARKADII ANDRIIOVYCH
Filed: 2003-02-28
Abstract: Method for production a wearproof coating, including mixture of powders with binding agent, their application on a surface of metal part and burn-off. As specified powders is used a mix of crushed utilized superhard alloys of various fractions which are mixed with metal powder solder before their application on surface of specified part which is set in the mould. The produced mix is scattered on the part, tamped and saturated with a liquid solution of organic binding agent. After evaporation of solvent the part with protective layer is extracted from the mould and heated up to fusion of solder in inductor field with external pressure.
Patent DO-P2002000334-A (DO)
Title: Pirimidinas biciclicas como inhibidores de metaloproteinasas de matriz
Inventor: DYER RICHARD DENNIS
IPC: A61K31/519
Filed: 2002-01-29
Abstract: Son inhibidores selectivos de MMP-13 las pirimidinas bicíclicas de la Fórmula I o una sal farmacéuticamente aceptable de las mismas, en la que R1 es hidrógeno o alquilo; R2, R3 y R4 incluyen hidrógeno, halo, alquilo, CCCH2m arilo, C02 alquilo, CO2CH2 arilo, COHN alquilo y CONHCH2m arilo; y X es O, S, SO, S02, CH2, C=O, CHOH, NH o NR5. Un compuesto de Fórmula I, o una sal farmacéuticamente aceptable del mismo, es útil para tratar el cáncer o la artritis.
Patent DO-P2006000178-A (DO)
Title: Derivados de isoquinolona sustituidos con piperidinilo
Inventor: KADEREIT DIETER
Filed: 2006-07-25
Abstract: La invencion se refiere a derivados de isoquinolona 6-piperidinil-sustituida de formula (I) o a derivados de isoquinolina de formula (I) utiles para el tratamiento y/o prevención de enfermedades asociadas con la Rhoquinasa y/o la fosforilacion mediada por la Rho-quinasa de la fosfatasa de la cadena ligera de miosina, y a composiciones que contienen tales compuestos.
Patent DO-P2014000052-A (DO)
Title: Anticuerpo anti-alfabeta tcr
Inventor: MENRAD ANDREAS
IPC: C07K16/28
Filed: 2014-03-10
Abstract: La presente invención se refiere a anticuerpos monoclonales humanizados que comprenden las CDR de BMA031 anticuerpo murino, que se unen al complejo aßTCR.CD3 y poseen propiedades biológicas mejoradas.
Patent DO-P2020000209-A (DO)
Title: Métodos para tratar cánceres y potenciar la eficacia de agentes terapéuticos para el redireccionamiento de células t
Inventor: FRANCOIS GAUDET
IPC: C07K19/00
Filed: 2020-11-13
Abstract: La descripción proporciona métodos para tratar un cáncer y/o destruir células tumorales en un sujeto, que comprende administrar una cantidad terapéuticamente eficaz de un anticuerpo anti-CD38 y un agente terapéutico para el redireccionamiento de células T al sujeto para tratar el cáncer. La presente descripción proporciona un método para potenciar la eficacia de un agente terapéutico para el redireccionamiento de células T en un sujeto que tiene un cáncer, que comprende administrar al sujeto un anticuerpo anti-CD38. La descripción también proporciona un método para tratar un mieloma múltiple en un sujeto, que comprende administrar una cantidad terapéuticamente eficaz de un anticuerpo biespecífico BCMAxCDS y un anticuerpo anti-CD38 al sujeto para tratar el mieloma múltiple. La descripción también proporciona una combinación farmacéutica que comprende un anticuerpo biespecífico GPRC5DxCD3. La descripción también proporciona un kit que comprende una composición farmacéutica que comprende un anticuerpo biespecífico BCMAxCD3 y un anticuerpo anti-CD38.
Patent EC-SP11011349-A (EC)
Title: Uso de sintético y biológico fungicidas en combinación para controlar hongos dañinos
Inventor: SCHERER MARIA
IPC: A01N63/22
Filed: 2011-09-23
Abstract: Uso combinado de fungicidas sintéticos y agentes de control biológico para controlar hongos dañinos. Para ser más precisos, un método para controlar hongos dañinos, el cual comprende al menos dos bloques de tratamiento, en donde en al menos un bloque de tratamiento las plantas son tratadas con al menos un fungicida sintético y en al menos un bloque de tratamiento las plantas son tratadas con al menos un agente de control biológico, con la condición de que el último bloque de tratamiento comprende someter las plantas al menos a un tratamiento con al menos un agente de control biológico.
Patent GB-187502010-A (GB)
IPC: A23F3/12
Filed: 1875-06-02
Granted: 1875-11-23
Abstract: 2010. Lyle, J., [Lyle, W. S.]. June 2. Tea.-Relates to machinery for rolling leaf tea. The tea is put into bags, and the bags are rolled between a rotating ribbed or corrugated barrel a and a surrounding cylindrical frame. This frame has circular or disc-shaped ends and its cylindrical portion consists of a series of bars b which fit into slots in the frame ends c so as to be capable of being moved either towards or away from the barrel a. The bars b may be adjusted by means of slotted discs d placed outside the frame ends c. These discs engage the ends of the bars b and can be turned round by means of toothed sectors and pinions actuated by a hand-wheel to move the bars b in or out. A feeding-board is placed at one side, and three of the bars b are omitted opposite the board to admit the bags of tea. A bag is removed by pushing the board in towards the barrel a. The bag is then rolled out on to the board. In the Provisional Specification it is stated that the bars may be moved in and out by means of adjusting- screws and springs.
Patent GB-189707092-A (GB)
Title: An Appliance for Supporting a Golf Club Bag.
Inventor: HEDDERWICK PERCY DAVID
Filed: 1897-03-18
Granted: 1898-01-22
Abstract: 7092. Kedderwick, P. D. March 18. Tripod and like stands. - Supports for golf-club bags are formed of removable hinged legs A, A connected to the ring C of the bag by means of two pairs of eyes E fixed on the ring, into which studs on the split upper ends of the legs engage. -
Patent GB-189710628-A (GB)
Title: Improvements in Outside Window Blinds.
Inventor: LEVOYER LOUIS
Filed: 1897-04-28
Granted: 1898-04-28
Abstract: 10,628. Levoyer, L. April 28. Window blinds.-Short outside blinds for the corners or angles of buildings are provided with rollers having straight parts a, a<1> and curved flexible parts x. The rollers are driven through gearing c, d. The bottom rod consists of curved parts v, v<1> and a flexible part x<1>. The central part of the roller consists of a spiral spring g, a number of tongued and grooved rings n, and a number of double rings o jointed together with gimbal joints. The spring bears on rings connected by rods. All the rings run on the rod i keyed to the axle k. The operating gear - wheels are on the sleeves m which are connected to the outer rings o. The spring is connected to the inner rings n. The part x<1> is similarly made.
Patent GB-189710939-A (GB)
Title: Improvements relating to Weighing Apparatus.
Inventor: HIPKINS WILLIAM EDWARD
Filed: 1897-05-03
Granted: 1898-03-19
Abstract: 10,939. Hipkins, W. E. May 3. Bearings are constructed having the lower part A grooved to form the bearing-surface for the knife-edge. A leg or support B is provided for the bearing, a n d i t s arms B', B' loosely fit the concave recesses on each side, while it is pivoted by a split pin or cottar C. With this arrangement the bearing is free to adjust itself upon the knife-edge, and lateral movement is prevented.
Patent GB-189712088-A (GB)
Title: Improvements in Apparatus for Controlling Electric Motors.
Filed: 1897-05-15
Granted: 1898-05-07
Abstract: 12,088. Siemens Bros. & Co. and Stopher, A. J. May 15. Motors, controlling.-A controlling-apparatus for electric locomotives, having more than one motor worked on the series-parallel system, consists of a commutating cylinder C and a vibrating switch G, both of which are operated from the same handwheel E, the construction being such that the current path for each succeeding operation on the motor is prepared but not completed until the switch has made a corresponding stroke. The cylinder C carries a number of contact-segments C<1>, engaging with conducting - springs D, and arranged so as to effect the necessary connections ; it is operated from the hand-wheel E through reducing-gear e, e<1>, e<2>, e<3>. The vibrating switch G is operated by a cam F<1> on a countershaft F driven by the wheels e, e<1>.
Patent GB-189713494-A (GB)
Title: Improvements in or connected with Mud-guards for Velocipedes.
Inventor: BLUEMEL FRANK HENRY
Filed: 1897-06-01
Granted: 1898-04-16
Abstract: 13,494. Bluemel, F. H., Bluemel, E. A., and Bluemel, C. W., [trading as Bluemel & Bros., C. W.]. June 1. Guards, mud. - Relates to arrangements to facilitate the attachment or removal of mud guards. To the under surface of the mud guard m clips c, similar to those described in Specification No. 20,410, A.D. 1896, are secured, while the headed ends s<1> of the stays s are bent at rightangles and take under the channelled portions c<1> of the clip, thereby securing the stays to the mud guard. The extremities b of the stays may be secured to the axle of the machine in a suitable manner, preferably by the means described in Specification No. 18,651, A.D. 1891. Straps such as g, and any number of suitable clips and stays, may be employed for securing the mud guard to the machine.
Patent GB-189713905-A (GB)
Title: Improvements in the Process of Obtaining Gas for Lighting, Heating, and Motive Power Purposes, and in Apparatus therefor.
Inventor: SOXHLET EMILE
Filed: 1897-06-05
Granted: 1898-06-04
Abstract: 13,905. Soxhlet, E., Berghe, F. van den, and Borremans frÞres. Jan. 22, [date claimed under Scc. 103 of Patents &c. Act, A.D. 1883]. Drawings to Specification. Regulators.-In the pipe supplying a burner with a mixture of acetylene and air or other gas is arranged a regulator and flame arrester, consisting of rolled-up metal gauze, having on its outside screw threads or helical ribs, and a tapered and perforated end nearer the burner.
Patent GB-189715121-A (GB)
Title: Improvements in Tyres for Cycles and other Vehicles.
Inventor: MANNES HEINRICH
Filed: 1897-06-24
Granted: 1897-07-31
Abstract: 15,121. Mannes, H. June 24. Tyres, pneumatic &c.- The tyre consists of a jacket a and a cushion b, or cushions b, b<1>, which support the wheel when the tyre is deflated and prevent the jacket from being pressed flat on the rim and damaged. The cushion which rests on the rim also forces the edges of the jacket into the grooves of the rim. In a modification, the cushion b is replaced by an elastic hoop, and in another the tyre is provided with a perforated cushion extending from the rim to the tread part of the cover. The inflating-valve is connected by a rubber tube or otherwise to the passage h.
Patent GB-189715976-A (GB)
Title: Improved Process relating to the Treatment and Production of Phosphates.
Inventor: MASSON-POLET EUGENE
Filed: 1897-07-05
Granted: 1898-05-20
Abstract: 15,976. Masson-Polet, E. July 5. Calcium phosphates.-Natural phosphatic calcium carbonates are converted into soluble phosphates similar to Thomas slag by two processes :-(1) Melting in the presence of metals or ores, such as iron, whereby the phosphorus is absorbed by the metal. (2) Dephosphorizing the metal thus obtained by the Thomas process in order to obtain the phosphate as phosphatic slag.
Patent GB-189719237-A (GB)
Title: A Railway Cycle Label.
Inventor: AWDRY THOMAS
Filed: 1897-08-20
Granted: 1898-02-05
Abstract: 19,237. Awdry, T. Aug. 20. Label holders.-Relates to a railway label for cycles. A case A of metal, leather, &c. is formed with three turned-over edges B, into which one or more direction cards may be inserted. The case has a spring clip secured to it for attachment to a tube of the cycle.
Patent GB-189722395-A (GB)
Title: Improvements in the Manufacture of Lead Carbonate, Ammonium Nitrate, Silicates of Sodium, and Caustic Soda.
Inventor: GARROWAY WILLIAM
Filed: 1897-09-30
Granted: 1898-09-10
Abstract: 22,395. Garroway, W. Sept. 30. White lead; ammonium nitrate; sodium silicate; alkaline hydrates.-Silica and sodium nitrate are heated and treated as described in Specifications No. 2489, A.D. 1896, and No. 7066, A.D. 1897, with superheated steam, nitric acid being given off and sodium silicate remaining. The nitric acid is led into earthenware pipes or stone towers containing scrap lead or litharge, whereby lead nitrate is formed. The lead nitrate is neutralized with ammonia, and precipitated by treatment under pressure with ammonia and carbonic acid or with ammonium carbonate. The ammonium carbonate may be obtained by treating ammonium sulphate with barium carbonate. White lead is precipitated, and a solution of ammonium nitrate is left. The residue of sodium silicate from the first process may be treated with lime to obtain caustic soda and calcium silicate.
Patent GB-189724143-A (GB)
Title: Improvements in Type-writing Machines.
Inventor: HAMILTON EMERY MANVILLE
Filed: 1897-10-19
Granted: 1897-11-27
Abstract: 24,143. Hamilton, E. M. Oct. 19. Type-writers.-Fig. 6 shows a side elevation. The platen 1 is mounted in the carriage 38, and is turned for line-spacing by a pawl on a lever 10*, pivoted to the carriage on a horizontal pivot. The lever or pawl carrier 10* has two pawls, one of which is movable and engages the ratchet-wheel to rotate it and the platen, and the other is rigid and engages the opposite side of the ratchet-wheel to stop the feed movement. The type-bars 11 are pivoted each on a radial plate 12 fixed adjustably and independently to the base-plate. The pivots of the type-bars 11 are in a curve which at its centre is at a greater distance from the printing- point than at its ends, so that the type-bars are shorter at the ends of the curve and increase in length towards its centre. Each type-bar is connected by a link 18 to a bell-crank lever 16, the other end of which is pivoted to the stem 17 of a key. The links 18 preferably work in slots in the plates 12. Slots 21 are also formed in the plates 12 for returning-springs 20, and slots 22 for pins connecting the levers 18 to the key stems 17. To the plates 12, below the levers 18 and in position to be operated thereby, are levers the inner ends of which engage a universal bar connected to the carriage feed dogs. The carriage is mounted to move transversely on the platen upon guides 38* to bring the other sets of type into operation. The carriage, which is shown in Fig. 6 in its central or normal position, is shifted by means of a rod or bar 39 pivoted to a post 40 on the carriage. The rod 39 has two slots or recesses for the pins 50 and 53 on levers 49, 52 pivoted at 55, 56. To these levers are also pivoted the shift keys 51, 54. A spring tends to lift the rod 39. The post 40 and another post at the other end of the carriage are connected by links to arms 42 of a shaft 43. Modifications of the type-bar mechanism are described, in one of which the plates 12 are bent laterally at their front ends, forming recesses for the type-bars, and the links 18 are at the sides of the plates ; in the other modification, the links 18 are connected to the type-bars above their pivots.
Patent GB-189724884-A (GB)
Title: Improvements in Electro-deposition Apparatus.
Inventor: HARRIS ALBERT FREDERICK
Filed: 1897-10-27
Granted: 1898-10-08
Abstract: 24,884. Harris, A. F. Oct. 27. Small articles, plating. -The tank 9 contains a removable frame 18, which supports, by means of adjustable arms and rollers, the end rings 15 of a rotating insulated or non-conductive cage 10. The latter consists of an open-ended cylinder having a removable endpiece 11 and a door 42, and sides formed with a series of grooves 13 having a large number of holes 14. Within the grooves are attached by pins a number of cathode strips 26 connected externally to a series of conductors 28, each of which is joined by a conductor 29 to a commutator 30 rotating synchronously with the cage. The wires 29 pass over a rotating wood block 31, so that those conductors 28 at the bottom of the cage are connected to the top of the commutator and hence are in circuit, and those at the top are connected to the bottom of the commutator, and hence are cut out. The cage and commutator are rotated from the shaft 22 by the gearing shown or by bands forming slings. The bracket 25 from the frame 18 carries a bar or bars 24 to which one or more curved anodes 23 are connected. The pins securing the cathodes have inwardlyprojecting ends, so that the small articles may be moved about thereby during deposition. In a modified form, the cage is formed of wires interlaced longitudinally and crosswise, and the cathodes are supported within the grooves from a bar passing through the cage below the anode, the parts from the grooves to the bar being insulated. In a further modification, the cage is formed of links, connected by cross-rods having inwardly-projecting pieces serving as cathodes.