Patent SG-11201906937Y-A (SG)
Title: Method for non-invasive monitoring of fluorescent tracer agent with background separation corrections
Inventor: KEATING JENNIFER
IPC: G01J1/42
Filed: 2018-01-30
Abstract: PREPROCESSING SUBUNIT BACKGROUND SUBTRACTION SUBUNIT ROTC CALCULATION FAULT DETECTION SUBUNIT SUBUNIT PROCESSING UNIT 302 ) 1308 1304 ) POST-AGENT ADMINISTRATION SELECTION SUBUNIT BACKGROUND CORRECTION SUBUNIT 1306 1310 1312 1-1 co O 00 O O (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 August 2018 (02.08.2018) WIP0 I PCT IiiimmoinionotiolomolomoliolimmommovoimIE (10) International Publication Number WO 2018/140984 Al (51) International Patent Classification: G01N 21/25 (2006.01) GO1J 1/42 (2006.01) C40B 30/04 (2006.01) G01J 1/58 (2006.01) F21V 9/16 (2006.01) GO1T 1/10 (2006.01) (21) International Application Number: PCT/US2018/016053 (22) International Filing Date: 30 January 2018 (30.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/452,021 30 January 2017 (30.01.2017) US (71) Applicant: MEDIBEACON INC. [US/US]; 1100 Corpo- rate Square Drive, Suite 175, St. Louis, MO 63132 (US). (72) Inventors: KEATING, Jennifer; 1631 Mercy Street, Apt. B, Mountain View, CA 94041 (US). SCHULTZ, Kimber- ly; 238 Mercy Street, Mountain View, CA 94041 (US). BECHTEL, Kate; 107 Hardy Circle, Pleasant Hill, CA 94523 (US). SOLOMON, Edward; 1110 Orange Avenue, Menlo Park, CA 94025 (US). (74) Agent: MCCAY, Michael, G. et al.; Armstrong Teasdale LLP, 7700 Forsyth Boulevard, St. Louis, MO 63105-1847 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (54) Title: METHOD FOR NON-INVASIVE MONITORING OF FLUORESCENT TRACER AGENT WITH BACKGROUND SEPARATION CORRECTIONS 236 FIG. 13 (57) : A method of monitoring a time-varying fluorescence emitted from a fluorescent agent from within a diffuse reflecting medium with time-varying optical properties is disclosed that includes providing at least two measurements obtained from a patient before and after administration of the fluorescent agent that includes an Fir me „signal detected adjacent to the medium by a filtered light detector during illumination of the medium by excitatory-wavelength light, and at least one DR signal selected from: a DR em , and DR emizi „ red signal. The method further includes identifying a post-equilibration portion of the measurement data set and transforming each Flr.signal within the post-equilibration portion of the measurement data set to an IF agent signal representing a detected fluorescence intensity emitted solely by the fluorescent agent from within the medium. [Continued on next page] WO 2018/140984 Al MIDEDIMOMMIMEEMOMMMONIHMOHMEHOIMI OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) The disclosed method includes removing the effects of leak-through of excitation-level light and removing the effects of autofluores- cence from the Fir.. signal.