Patent SG-11201909652W-A (SG)
Title: Neoantigen identification, manufacture, and use
Inventor: BOUCHER THOMAS
IPC: C07K7/08
Filed: 2018-04-19
Abstract: WO 18/ 195 357 Al Example 2 Example 3 / Example 1 / Example 2 • - Example 3 - Example 4 FIG. 13J Example 1 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 October 2018 (25.10.2018) WIPO I PCT (51) International Patent Classification: GOOF 19/22 (2011.01) A61K 35/15 (2015.01) A61K 39/00 (2006.01) C07K 7/08 (2006.01) A61K 38/10 (2006.01) (21) International Application Number: PCT/US2018/028438 (22) International Filing Date: 19 April 2018 (19.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/487,469 19 April 2017 (19.04.2017) US (71) Applicant: GRITSTONE ONCOLOGY, INC. [US/US]; 5858 Horton Street, Suite 210, Emeryville, CA 94608 (US). (72) Inventors: BOUCHER, Thomas; Gritstone Oncology, Inc., 5858 Horton Street, Suite 210, Emeryville, CA 94608 (US). BULIK-SULLIVAN, Brendan; Gritstone Oncolo- gy, Inc., 5858 Horton Street, Suite 210, Emeryville, CA 94608 (US). BUSBY, Jennifer; Gritstone Oncology, Inc., 5858 Horton Street, Suite 210, Emeryville, CA 94608 (US). YELENSKY, Roman; Gritstone Oncology, Inc., 5858 Horton Street, Suite 210, Emeryville, CA 94608 (US). (74) Agent: WHITEHEAD, Andrew P. et al.; Fenwick & West LLP, 801 California Street, Mountain View, CA 94041 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: NEOANTIGEN IDENTIFICATION, MANUFACTURE, AND USE ill~~~~~~~~ 0111111010VIIIOH olo mull! omioommo oimIE (10) International Publication Number WO 2018/195357 Al (57) : Disclosed herein is a system and methods for de- termining the alleles, neoantigens, and vaccine composition as de- termined on the basis of an individual's tumor mutations. Also dis- closed are systems and methods for obtaining high quality sequenc- ing data from a tumor. Further, described herein are systems and methods for identifying somatic changes in polymorphic genome data. Finally, described herein are unique cancer vaccines. [Continued on next page] WO 2018/195357 Al MIDEDIMOMMIDEFIEDMOMMEHOMINHINVOIMIE Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3))