Patent SG-11201408232R-A (SG)
Title: 1,2,4-triazine-6-carboxamide kinase inhibitors
Inventor: JIA ZHAOZHONG J
IPC: A01N43/707
Filed: 2013-06-14
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 December 2013 (27.12.2013) WIPOIPCT (10) International Publication Number WO 2013/192049 A2 (51) International Patent Classification: C07D 253/075 (2006.01) C07D 417/12 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01) C07D 413/12 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 403/14 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01) C07D 471/04 (2006.01) C07D 413/14 (2006.01) C07D 495/04 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/046006 14 June 2013 (14.06.2013) English (30) Priority Data: 61/663,499 13/841,472 22 June 2012 (22.06.2012) 15 March 2013 (15.03.2013) English US US (71) Applicant: PORTOLA PHARMACEUTICALS, INC. [US/US]; 270 E. Grand Avenue, Suite 22, South San Fran­ cisco, California 94080 (US). (72) Inventors: JIA, Zhaozhong J.; 3416 Leafwood Court, San Mateo, California 94403 (US). KANE, Brian; 5964 Mer- riewood Drive, Oakland, California 94611 (US). ROSE, Jack; 307 27th Avenue, San Mateo, California 94403 (US). BAUER, Shawn M.; 181 Beachview Avenue, Paci- fica, California 94044 (US). SONG, Yonghong; 860 Po­ laris Avenue, Foster City, California 94404 (US). XU, Qing; 836 Polaris Avenue, Foster City, California 94404 (US). PANDEY, Anjali; 4506 Amiens Avenue, Fremont, California 94555 (US). (74) Agents: HOPKINS, Mark H. et al.; Kilpatrick Townsend & Stockton LLP, Eighth Floor, Two Embarcadero Center, San Francisco, California 94111 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — without international search report and to be republished upon receipt of that report (Rule 48.2(g)) CJ as o CJ as i-H o CJ (54) Title: l,2,4-TRIAZINE-6-CARBOXAMIDE KINASE INHIBITORS (57) Abstract: Provided are triazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, meth­ ods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.