baber/WOPTO huggingface dataset:
Patent EP-1572066-A2 (EP)
Title: Novel method and composition for inhibition of angiogenesis and tumor growth using compounds based on a sequence within mmp-2
Inventor: BROOKS PETER C
IPC: A61P9/10
Filed: 2002-05-31
Abstract: The present invention provides methods and compositions for inhibiting angiogenesis, tumor growth and treating disease states using a peptide that contains a specific amino acid sequence of matrix metalloproteinase 2 (MMP-2). In one embodiment, the invention provides a peptide, which comprises the amino acid sequence Ile-Phe-Ala-Gly-Asp-Lys-Phe-Trp-Arg, preferably flanked by cysteine residues at the amino and carboxy termini. Additionally, the invention provides compositions for inhibiting angiogenesis or tumor growth or for treating disease states comprising organic and non-peptidic mimetics based on the above amino acid sequence as well as optimized sequences flanking the region of MMP-2 within which the sequence lies. Also provided are methods for detecting angiogenesis, tumorous tissue, metastases, and tumor invasion into a tissue by contacting a composition of the invention with a tissue and methods for screening compositions of the invention.
Patent EP-1411963-A2 (EP)
Inventor: DAS GUPTA TAPAS K
IPC: C12N15/09
Filed: 2002-01-15
Abstract: L'invention concerne des facteurs cytotoxiques trouvant une utilisation dans la modulation de la mort cellulaire, ainsi que leur utilisation dans des méthodes de traitement d'états pathologiques associés à la nécrose ou à l'apoptose. L'invention concerne également des méthodes d'identification d'agents actifs utiles dans le traitement d'états pathologiques associés à la mort cellulaire. On a découvert que différents agents pathogènes produisent un ou plusieurs facteurs cytotoxiques différents présentant une activité anticancéreuse. Des facteurs cytotoxiques sensiblement purs peuvent être utilisés dans une méthode de traitement d'une maladie infectieuse ou d'un cancer.
Patent EP-1409466-A2 (EP)
Inventor: CANON-KOCH STACIE S
IPC: A61K38/04
Filed: 2002-06-11
Abstract: Compounds of Formula (I), where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.
Patent EP-1418813-A2 (EP)
Title: Procedes, compositions et necessaires relatifs a des molecules chitinases et de type chitinase ainsi qu'a des maladies inflammatoires
Inventor: ELIAS JACK A
IPC: A61P11/06
Filed: 2002-07-23
Abstract: L'invention concerne des compositions et des procédés destinés au traitement de maladies inflammatoires (par exemple, l'asthme, la broncho-pneumonie chronique obstructive, la maladie intestinale inflammatoire, la dermatite atopique, l'atopie, l'allergie, la rhinite allergique, la sclérodermie, et analogues), relatifs à l'inhibition d'une molécule de type chitinase. L'invention concerne également des procédés d'identification de nouveaux composés destinés au traitement de maladies inflammatoires, telles que, entre autre, l'asthme, la broncho-pneumonie chronique obstructive et analogues. Cette invention démontre, pour la première fois, que l'expression de IL-13, ainsi que d'une molécule du type chitinase, diffuse et/ou est associée aux maladies inflammatoires et que l'inhibition de la molécule de type chitinase traite et va même jusqu'à éviter la maladie. En somme, cette invention concerne la découverte que l'inhibition d'une molécule de type chitinase traite et prévient une maladie inflammatoire.
Patent EP-1421434-A2 (EP)
Inventor: SILSBY PAUL ALISTAIR
IPC: G02F1/1335
Filed: 2002-08-13
Abstract: Selon la présente invention, il est possible d'améliorer la visibilité d'un grand écran en utilisant un écran antireflet placé sur une pluralité de pixels. L'effet antireflet est formé par des éléments (17) qui possèdent une surface (18) placée en regard de la position à partir de laquelle l'affichage est regardé . Chaque surface (18) présente une forme sensiblement parabolique pour disperser la lumière incidente sur l'écran.
Patent EP-1373597-A2 (EP)
Inventor: STEINMETZ JEAN
IPC: C23C22/48
Filed: 2002-03-21
Abstract: The invention relates to a method for treating a metal surface by carboxylation before forming, said metal being selected from zinc, iron, aluminium, copper, lead and the alloys thereof as well as copper-coated, aluminium-coated, galvanised steels. Said method is carried out in oxidising conditions in relation to the metal by bringing said metal into contact with an aqueous, organic or hydro-organic bath comprising at least one organic acid in free form or in salt form. The inventive method is characterised in that: the organic acid is a saturated or unsaturated aliphatic monocarboxylic or dicarboxylic acid; the organic acid is in solution and/or emulsion in the bath at a concentration greater than 0.1 mole/litre; the pH of the bath is acid.
Patent EP-1377597-A2 (EP)
Inventor: FINGER JOSHUA
IPC: C07K14/705
Filed: 2002-03-22
Abstract: L'invention concerne de nouveaux polynucléotides codant des polypeptides APEX4, ainsi que des fragments et homologues de ces derniers. L'invention concerne également des polynucléotides codant des variants et des variants d'épissage de polypeptides APEX4, APEX4v1 etAPEX4sv1, respectivement. Elle concerne en outre des vecteurs, des cellules hôtes, des anticorps, ainsi que des procédés de recombinaison et de synthèse permettant de produire lesdits polypeptides. L'invention concerne également des procédés diagnostiques et thérapeutiques conçus pour appliquer ces nouveaux polypeptides APEX4, APEX4v1 etAPEX4sv1 au diagnostic, au traitement et/ou à la prévention de diverses maladies et/ou troubles en relation avec ces polypeptides. L'invention concerne enfin des procédés de criblage permettant d'identifier des agonistes et antagonistes desdits polynucléotides et polypeptides.
Patent EP-1438479-A2 (EP)
Inventor: BISE DOUGLAS E
IPC: E21D20/00
Filed: 2002-09-06
Abstract: Fluid roof bits for mining typically supply high pressure water to a location immediately adjacent the cutting insert (52) of the roof bit to flush debris and cool the cutting insert. The present invention is a drill steel assembly for a wet roof bit that reduces the fluid pressure loss supplied to the roof bit. A drill head body (54) is connected to the drill steel by an intermediate adaptor (58). The adaptor has a spring loaded button (62) thereon that mates with an opening in the drill head body so that the drill head body (54) can be conveniently snapped onto the drill head assembly. A bushing seal (56) made from a flexible material is clamped between said drill steel adaptor and the drill head body to limit fluid pressure losses.
Patent EP-1421638-A2 (EP)
Inventor: ARMSTRONG FRASER
IPC: H01M8/10
Filed: 2002-08-23
Abstract: La présente invention concerne une pile à combustible et un procédé pour faire fonctionner ladite pile à combustible. Ladite pile à combustible comprend une anode sur laquelle est adsorbé un catalyseur, ledit catalyseur comprenant une hydrogénase qui est en contact électronique direct avec l'anode.
Patent EP-1389203-A2 (EP)
Inventor: FIGG WILLIAM D
IPC: A61K31/454
Filed: 2002-02-26
Abstract: A number of thalidomide metabolites having superior anti-angiogenic properties have now been isolated and identified. In addition, thalidomide analogs that mimic the effects of the isolated and identified active thalidomide metabolites, and variations of such thalidomide analogs, have been developed. Such thalidomide analog compounds show enhanced potency in the inhibition of undesirable angiogenesis without the undesirable effects of administration of thalidomide.
Patent EP-1345317-A2 (EP)
Inventor: MANKU TAJINDER
IPC: H03L7/099
Filed: 2003-03-10
Abstract: The invention provides a system and method of generating a number of inputs
to the mixer elements in a direct conversion (homodyne) receiver
configuration using Virtual Local Oscillator (VLO) techniques. These
generated inputs meet the requirement that they must have a fixed and stable
phase-relationship, as well as being correctly related in terms of their power
spectra relative to the operating radio (RF), intermediate (IF), and baseband
frequencies of the system, and that when applied to the mixer elements they
permit the mixer elements to create internally the effect of applying the Local
Oscillator signal at a suitable frequency.
Patent EP-1369332-A2 (EP)
Inventor: CROSS MICHAEL
IPC: B61L17/00
Filed: 2003-06-04
Abstract: An automated manipulation system is provided for manipulating one or more vehicles in a transit
system. The automated manipulation system includes a vehicle control mechanism in
communication with a vehicle for receiving, processing and transmitting signals for controlling
the operation of the vehicle. The system also includes a central control mechanism in wireless
communication with the vehicle control mechanism for receiving, processing and transmitting
signals for controlling the vehicle control mechanism and thereby initiating a manipulation
operation in the vehicle. The manipulation operation is one of: adding a vehicle to the system;
removing a vehicle from the system; coupling a first vehicle to a second vehicle; and uncoupling
a first vehicle from a second vehicle. A method of automatically manipulating at least one
vehicle in a transit system is also provided.
Patent EP-1389698-A2 (EP)
Inventor: ORE THOMAS GEORGE
IPC: F16H59/02
Filed: 2003-08-08
Abstract: The mechanism has a housing which supports the two shafts and encloses a coupling movable between engaged and disengaged positions. A plug is mountable into an opening formed to the housing, and is movable between two locking positions to selectively lock the coupling at the engaged position or the disengaged position. At the engaged position, the coupling connects the shafts to each other. At the disengaged position, the coupling disconnects the shafts from each other.
Patent EP-1376889-A2 (EP)
Inventor: OZLUTURK FATIH
IPC: H04B1/7097
Filed: 1999-01-27
Abstract: The present invention relates to a traffic signal canceller (101) for use in a
receiver that receives communication signals from a transmitter (19) over a
CDMA air interface that removes at least one unwanted traffic signal from a
desired traffic signal prior to decoding.
Patent EP-1431545-A2 (EP)
Inventor: HUESGES HANS-JUERGEN
IPC: F02B27/02
Filed: 2003-08-26
Abstract: Leaf elements (5) are arranged at the outer edge region of the switching flap base body (4). The leaf elements lie against a bead-shaped ridge of an inner wall of the air duct system, in the closed state of the switching flap (1), and thereby seal the air duct. In the open state, the switching flap and the ridge cause only a small flow resistance.
Patent EP-1422631-A2 (EP)
Inventor: ZAKRZEWSKI RADOSLAW ROMUALD
IPC: G06F17/17
Filed: 2003-09-25
Abstract: Interpolation techniques are described for use with data that may not be uniform
and may be characterized as scattered. Such data may be obtained in instances where data
acquisition may not be easily controlled such as in obtaining experimental data for use
with models. Data interpolation techniques may be used in connection with the
experimental data to produce a more complete and accurate data set representative of a
variety of conditions using as input the non-uniform or scattered data. Such data sets
may be used in a variety of applications including providing a realistic and complete set
of data for training and verifying neural networks.
Patent EP-1422592-A2 (EP)
Inventor: KURAKANE HIROSHI
IPC: G06F1/06
Filed: 2003-11-20
Abstract: This invention relates to a clock control system
including a CPU, a peripheral functional block for the CPU,
a frequency multiplication circuit which multiplies the
frequency of an input system clock and outputs the
multiplied system clock, a plurality of frequency division
circuits which divide the frequency of a signal output from
the frequency multiplication circuit to generate clocks to
be supplied to the CPU and peripheral functional block, and
a clock controller which changes the frequency
multiplication ratio of the frequency multiplication
circuit to 1/N (positive integer) and then changes the
frequency division ratio of the frequency division circuit
arranged on the input stage of the peripheral functional
block to 1/N in order to set the CPU to a low-power
consumption mode, and a method of controlling the clock
control system.
Patent EP-1359565-A2 (EP)
Inventor: MI XIANG-DONG
IPC: G09G3/36
Filed: 2003-04-22
Abstract: A driving scheme for chiral nematic (cholesteric) liquid crystal
displays comprises a preparation step, a holding-selection step, and an evolution
step. The column and row drivers require only 2 voltage levels:  U  or 0. Duty
cycles and phases in the preparation step, the holding-selection step, and the
evolution step, are varied to generate optimized contrast, brightness, and gray
levels on cholesteric liquid crystal
Patent EP-1364779-A2 (EP)
Inventor: SHIH RICHARD
IPC: G03F7/24
Filed: 2003-04-07
Abstract: In one embodiment, an imaging system and method for operating same
are provided which includes a media support surface (22) for
supporting a printing plate (18) during recording of an image
thereon, a leading edge clamping mechanism (40) for securing a
leading edge (38) of the printing plate (18) to the media support
surface (22), and a trailing edge clamping mechanism (44) for
securing a trailing edge (42) of the printing plate (18) to the
media support surface (22). An actuation system (106) is used to
actuate both the leading edge clamping mechanism (40) and the
trailing edge clamping mechanism (44).
Patent EP-1331424-A2 (EP)
Inventor: STASKIEWICZ ALMA L
IPC: B28B21/82
Filed: 2003-01-22
Abstract: A three piece full port ball valve for use with a form for producing a cast concrete
article is provided wherein the housing (322) of the valve has been modified by creating
openings (356,359) through the valve housing to access the flow opening in the ball member for
clearing concrete slurry therefrom after the form has been filled. Additional openings (362,365,368) in
the housing (322) at other locations can be created for cleaning around the ball member and the
inside of the housing.
Patent EP-1348973-A2 (EP)
Inventor: NYGAARD RICHARD A JR
IPC: G01R31/317
Filed: 2003-03-07
Abstract: An eye diagram analyzer can assign a plurality of SUT data signals to be members of a labeled
group (6) of channels. There may be a plurality of such groups. The measured data for components within
a group can be merged according to various different modes into a composite eye diagram
presentation (12). When a composite eye diagram is being displayed, the operator may position a screen
pointer (cursor) (17) over some interesting part of the eye diagram, and the analyzer will display a
list (23) of those channels that contributed to the displayed pixels in that part of the eye diagram, as well as other
related information. The operator may also select (31) a channel from among the group, and then have
the displayed pixels for which it is responsible be displayed in a selected color or otherwise
highlighted (32) in a way that allows them to be distinguished from all others.
Patent EP-1471897-A2 (EP)
Inventor: LAUTT WAYNE W
IPC: A61K31/445
Filed: 2003-01-27
Abstract: L'invention concerne l'utilisation d'un antagoniste de la phosphodiestérase en vue de réduire la résistance à l'insuline, et à amplifier l'effet de l'oxyde nitrique sur l'absorption du glucose par les muscles du squelette chez un mammifère. Dans certains cas, l'antagoniste est ciblé vers le foi. Dans certains cas, la résistance à l'insuline est une résistance à l'insuline dépendant de la substance sensibilisant à l'insuline hépatique ('SSIH').
Patent EP-1485108-A2 (EP)
Inventor: SERA TAKASHI
IPC: C12Q1/68
Filed: 2003-01-17
Abstract: The present invention is directed to nucleic acid target-specific chimeric proteins comprising a nuclear-envelope and/or nuclear-lamina binding domain and a DNA binding domain. These proteins, as well as the nucleic acids encoding those proteins, can be used in methods to repress or down-regulate expression of selected genes. The DNA binding domains are preferably from naturally-occurring zinc finger proteins (ZFPs) or artificial zinc finger proteins (AZPs). Molecular switch systems for gene regulation are also provided.
Patent EP-1490737-A2 (EP)
Inventor: JOHNSON CHARLES
IPC: G05B19/408
Filed: 2003-02-14
Abstract: Au moins un mode de réalisation mentionné dans la présente invention comporte un procédé permettant la compensation des délais dans un circuit d'un codeur série. Le procédé consiste à déterminer au moins un délai associé au circuit du codeur série. Ce procédé comprend également l'ajustement d'un signal horloge interne reçu par une mémoire qui reçoit des données et est associée au codeur série pour tenir compte du ou des délai(s) déterminé(s).
Patent EP-1483422-A2 (EP)
Inventor: GAGNIERE JACQUES
IPC: C22C21/02
Filed: 2003-02-12
Abstract: Aluminum alloy strips which are 30-150 mmu thick, having a composition (in wt. %): Si<0.4; Fe: 1.5-1.9; Mn: 0.04-0.15; other elements: <0.05 each and 0.15 in total, remainder aluminum. The strips are used, in particular, for the manufacture of trays and dishes for the distribution of foodstuffs and fast food.
Patent EP-1539998-A2 (EP)
Title: Methodes et compositions pour synthese de molecules d'acides nucleiques a l'aide de sites de reconnaissance multiples
Inventor: CHESNUT JONATHAN D
IPC: C12N15/10
Filed: 2003-06-05
Abstract: la présente invention concerne des compositions et des méthodes de clonage récombinatoire. Ces compositions comprennent des vecteurs présentant de multiples sites de recombinaison et/ou de multiples sites de reconnaissance de la topoisomérase. Les méthodes permettent le clonage simultané d'au moins deux molécules différentes d'acides nucléiques. Dans certains modes de réalisation, les molécules sont fusionnées alors que dans d'autres modes de réalisation, elles sont insérées dans des sites distincts de vecteur. De façon générale, l'invention permet également de lier ou de joindre par recombinaison un certain nombre de molécules et/ou de composés identiques ou différents (tels que composés chimiques, médicaments, protéines ou peptides, lipides, acides nucléiques ou hydrates de carbone). De plus, l'invention porte sur des cellules hôtes comprenant les molécules d'acides nucléiques de l'invention ou des molécules obtenues par les méthodes de l'invention, ainsi que des trousses renfermant les compositions, cellules hôtes et molécules d'acides nucléiques de l'invention qui peuvent s'utiliser pour synthétiser des molécules d'acides nucléiques selon les méthodes de l'invention.
Patent EP-1499538-A2 (EP)
Inventor: JANSSEN FRANK
IPC: B65D1/00
Filed: 2003-04-04
Abstract: A one-way valve for the recontamination-protected repeated discharge of a flowable material from a container of a preferably reducible volume contains a valve seat which consists of a rigid plastic material and which is arranged in the container neck and comprises a base body which rests on the inner wall of the container neck and contains at least one through hole, and a projection which extends in axial direction of the container neck towards the exit opening. The valve seat has arranged thereabove an elastic seal which comprises an annular section covering the at least one through hole, and a sleeve-like section which surrounds the projection at a radial distance with the exception of its end section which in the closed state of the one-way valve rests in the exit opening on the end section of the projection. A sterilization element of silver or of another metal having an oligodynamic action may be arranged in the intermediate space between the projection of the valve seat and the elastic seal. The application of pressure to the contents of the container has the effect that the annular section of the seal releases the at least one through hole of the valve seat, the end section of the sleeve-like part of the seal exiting from the exit opening and releasing the same. The seal will then return into the initial state. The contents of the container is safely sealed against the ingress of contaminants.
Patent EP-1520229-A2 (EP)
Inventor: LERICHE STEPHANE
IPC: G06F9/46
Filed: 2003-06-27
Abstract: The invention concerns a networking system for aeronautical equipment items onboard an heavier-than-air aircraft comprising, for each equipment item, an object-oriented interface (1, 2; 3, 4) with so-called object-front means (1, 2) for perceiving the onboard equipment whereto it is assigned, as an object, in terms of object-oriented programming, capable of communicating with other objects in terms of object-oriented programming in accordance with an object-oriented client/server model and with so-called observer objects (2, 4) identifying events resulting from the operating conditions of the onboard equipment.
Patent EP-1518151-A2 (EP)
Inventor: SCHEDEL THORSTEN
IPC: G03F7/20
Filed: 2003-06-25
Abstract: The invention relates to an arrangement for the depositing or withdrawing of reticles, provided with a magazine housing in which an withdrawing and depositing magazine may be inserted, which has at least one horizontal housing compartment for housing a reticle, a manipulator and a drive unit for moving the reticle magazine and/or the manipulator relative to each other. The invention further relates to a method for the withdrawing or depositing of reticles in photolithographic processes, whereby reticles provided with pellicles are moved from a housing compartment in the withdrawing and depositing magazine after insertion of an withdrawing and depositing magazine in a magazine housing, by means of a manipulator from a housing compartment in the withdrawing and deposition magazine and supplied to the lithographic process. The aim of the invention is to prevent reticles, pellicles arranged thereon or magazines to lie outside the determined tolerance range of the manipulation region of the manipulator and thus prevent damage thereto or destruction thereof, at least for the reticle, on application to the photolithographic process. The above is achieved, whereby a corresponding sensor is provided for the reticle, at least indirectly connected to the drive unit for control thereof, from which data relevant to the reticle may be obtained and by means of which data the movement of the manipulator is controlled.
Patent EP-1570106-A2 (EP)
Inventor: SEIDEL FRANK
IPC: C23C16/448
Filed: 2003-11-26
Abstract: The invention relates to a method and a device for the CVD coating of a workpiece. In the method for CVD coating, in particular for aluminizing, at least one workpiece, a coating gas is generated which serves for the coating of the or each workpiece. According to the invention, workpieces for coating are arranged in a coating chamber with coating granulate arranged in the vicinity of the workpieces for coating. The coating chamber, together with the workpieces for coating and together with the coating granulate are heated to the process temperature. After reaching the process temperature, a process gas is introduced onto the coating granulate, which leads to the generation of the coating gas.
Patent EP-1543573-A2 (EP)
Inventor: BAEUERLEIN PETER
IPC: H01M10/34
Filed: 2003-09-26
Abstract: L'invention concerne un matériau de cathode actif à base d'hydroxyde mixte de nickel, destiné à être utilisé dans des accumulateurs alcalins et présentant une répartition granulométrique bimodale spéciale à l'origine de ses bonnes caractéristiques. Le matériau à base d'hydroxyde mixte de nickel selon l'invention est produit de manière particulièrement avantageuse dans un processus de précipitation continu dans un réacteur à écoulement en boucle disposant d'une zone de décantation intégrée.