baber/WOPTO huggingface dataset:
Patent CA-2790641-A1 (CA)
Inventor: BRAIN CHRISTOPHER THOMAS
IPC: A61K31/519
Filed: 2011-02-17
Abstract: The invention is directed to novel deuterated pyrrolopyrimidine compounds of formula (I) wherein R1 and R2 are defined below and to salts, including pharmaceutically acceptable salts thereof. The compounds of the present invention are CDK4/6 inhibitors and could be useful in the treatment of diseases and disorders mediated by CDK4/6, such as cancer, including mantle cell lymphoma, liposarcoma, non small cell lung cancer, melanoma, squamous cell esophageal cancer and breast cancer. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CDK4/6 activity and to the treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
Patent CA-2791390-A1 (CA)
Inventor: MEIRI ODED
IPC: A61M25/01
Filed: 2011-03-07
Abstract: Disclosed herein are representative embodiments of methods, apparatus, and systems used to deliver a prosthetic heart valve to a deficient valve. In one embodiment, for instance, a support member is positioned to at least partially surround the native leaflets of a valve. A locking member is used to couple both ends of the support member, forming a support band. An expandable prosthetic heart valve is delivered into the native heart valve and expanded while the expandable prosthetic valve is at least partially within the support band, thereby causing one or more of the native leaflets of the native heart valve to be frictionally secured between the support band and the expanded prosthetic heart valve.
Patent CA-2792593-A1 (CA)
Inventor: DAYAL YOGESHWAR
IPC: H05H6/00
Filed: 2012-10-18
Abstract: Apparatuses and methods produce radioisotopes in instrumentation tubes of operating commercial nuclear reactors. Irradiation targets may be inserted and removed from instrumentation tubes during operation and converted to radioisotopes otherwise unavailable during operation of commercial nuclear reactors. Example apparatuses may continuously insert, remove, and store irradiation targets to be converted to useable radioisotopes or other desired materials at several different origin and termination points accessible outside an access barrier such as a containment building, drywell wall, or other access restriction preventing access to instrumentation tubes during operation of the nuclear plant.
Patent CA-2796038-A1 (CA)
Title: Thick inorganic fiber webs and methods of making and using
Inventor: ENDLE JAMES P
IPC: D04H1/58
Filed: 2011-04-05
Abstract: Monolithic gravity-laid inorganic fiber webs that are greater than about 5 cm in thickness are disclosed. Methods of making and using such webs are also disclosed. The gravity-laying process comprises mechanically separating inorganic fibers and collecting the fibers as a monolithic thick web, and may comprise blending of multiple types of inorganic fibers and/or blending of inorganic particulate additives with the fibers.
Patent CA-2796320-A1 (CA)
Title: Membrane separation apparatus with air bubble plates
Inventor: TOYOOKA KAZUHIRO
IPC: B01D65/02
Filed: 2011-03-25
Abstract: Disclosed is a membrane separation device wherein the cleaning effect of a membrane element by scrubbing is improved. The membrane separation device (14) comprises: separation membranes (5) (membrane elements) which are immersed in a liquid to be processed that is inside a processing tank (15); an aeration means (2) which diffuses bubbles (6) for cleaning the separation membranes (5); and a bubble entrapment plate (3) provided between the aeration means (2) and the separation membranes (5). The bubble entrapment plate (3) gathers the bubbles (6) diffused from the aeration means (2) by entrapping the bubbles (6) and forms bubbles (6) of a large diameter. The cleaning effect of the separation membranes (5) is improved by making the large-diameter bubbles (6) act on the separation membranes. Furthermore, the multilayer provision of bubble entrapment plates (3) enables the bubbles (6) to act on the entirety of the separation membranes (5).
Patent CA-2797001-A1 (CA)
Inventor: MEYER JEAN-PHILIPPE
IPC: C07D307/54
Filed: 2010-09-08
Abstract: A novel class of diyne compounds and diyne salts provided herein are effective and potent Ole1 protein inhibitors, useful for treating fungal pathogens. Compounds, fungicides and methods are provided as novel, potent and broad spectrum antifungal agents for treatment against a wide variety of fungal pathogens in humans and animals, and in the agricultural setting.
Patent CA-2802045-A1 (CA)
Inventor: SHORE T MICHAEL
IPC: B21B1/18
Filed: 2011-05-16
Abstract: A modular rolling mill has a mill pass line along which products are rolled in a rolling direction. The rolling mill comprises first gear units arranged along a first line parallel to the mill pass mill line. Each first gear unit is driven individually by a motor and has a pair of mechanically interconnected output shafts. Second gear units are arranged along a second line between and parallel to both the first line and the mill pass line. Each second gear unit has a pair of mechanically interconnected input shafts driving a pair of output shafts. Rolling units are arranged in succession along the mill pass line. Each rolling unit is driven by an input shaft and has a pair of mechanically interconnected roll shafts carrying work rolls. First couplings connect the output shafts of each first gear unit to input shafts of two successive gear units, and second couplings releasably connect the output shafts of the second gear units to the input shafts of two successive rolling units.
Patent CA-2804332-A1 (CA)
Inventor: YATES TRAVIS L
IPC: B64C13/04
Filed: 2013-02-01
Abstract: According to one embodiment, a control assembly includes a post, a grip, and a shaft.                           The post has a top, a bottom, and a body joining the top to the bottom.  The shaft has a first end coupled proximate to the body below the top and a second end opposite the first end coupled to the grip. The shaft positions at least part of the grip directly over the top of the post.
Patent CA-2804707-A1 (CA)
Title: Tailored properties by post hot forming processing
Inventor: CHAREST PASCAL P
IPC: B29C43/00
Filed: 2011-06-23
Abstract: A method of forming a shaped product from an initial blank comprises subjecting the initial blank to a hot forming and press hardening operation to form the shaped product with substantially a uniform first tensile strength. Subsequently, the shaped product is at least partially immersed into a fluidized bed that is maintained within a known range of operating temperatures. While the shaped product is immersed into the fluidized bed, a first region of the shaped product is heated selectively to above a known temperature. The first region is then cooled, such that the first region attains a second tensile strength that is substantially less than the first tensile strength.
Patent CA-2804852-A1 (CA)
Inventor: WIEDMANN HANS-JOACHIM
IPC: B65D1/24
Filed: 2011-05-23
Abstract: L'invention concerne une caisse à bouteilles (10, 10'), comprenant un fond de caisse (11), quatre éléments latéraux (12, 13, 14, 15) appliqués sur le fond, et une structure (16) à compartiments (17) pour la réception des bouteilles, la caisse à bouteilles (10, 10') présentant en outre une caractéristique de structure (20) sur au moins deux éléments latéraux et en fond de caisse, qui permet un gerbage/emboîtement de plusieurs caisses à bouteilles. Cette caisse à bouteilles (10, 10') est appropriée, d'une part, pour le transport de bouteilles, qu'elles soient remplies ou vides, et d'autre part, également pour le transport sortant et entrant des caisses à l'état vide.
Patent CA-2808009-A1 (CA)
Inventor: BOWEN BRYAN
IPC: F42B39/14
Filed: 2011-08-15
Abstract: The invention covers a missile canister (10) for accommodating a missile (20) along a longitudinal axis (L) of the canister. The canister comprises a plurality of generally planar longitudinal wall portions (14) connected together to form a tubular vessel having a polygonal cross - section. The interconnecting portions (16) between wall sections (14) are generally flexible so that when a missile (20) is launched the bending moment at the interconnecting portions (16) generated by the increase of pressure in the vessel is substantially less than the bending moment (10) generated at the wall portions (14). The interconnecting portions (16) allow relative angular deflection between adjacent wall portions (14) at respective interconnecting portions (16) when said missile (20) is launched.
Patent CA-2810141-A1 (CA)
Inventor: HOBART RICHARD L
IPC: F02N19/06
Filed: 2013-03-28
Abstract: An engine preheating system supports starting industrial and/or diesel engines in cold weather, eliminating the need for cold weather idling. The system preheats the engine coolant, bringing the entire machine up to a warm starting condition. This provides good lubrication and immediate heat availability. The system is fully portable and does not rely on commercial power, operable at any location. The system utilizes propane fuel, which is widely available. The propane fuel burns quietly and cleanly as opposed to fuel oil. The system includes numerous safety features, such as flow indicators and modern microprocessor technology to ensure safe operation.
Patent CA-2810297-A1 (CA)
Inventor: KENNEDY JAMES
IPC: E03D9/052
Filed: 2010-04-09
Abstract: A fan adaptor for retrofitting a toilet to convert the toilet into a ventilated toilet includes an adaptor body adapted to be disposed between a rear portion of a toilet bowl and a holding tank, a flush valve subassembly having a drain and an upright pipe adapted to extend into the holding tank, the upright pipe being adapted to convey water from the holding tank to the drain and an air exhaust pipe in fluid communication with the drain to enable malodorous air from the toilet bowl to be drawn through the air exhaust pipe.
Patent CA-2812862-A1 (CA)
Title: Enteric coated, low-strength pancrelipase formulations
Inventor: ORTENZI GIOVANNI
IPC: A61K9/28
Filed: 2011-09-30
Abstract: The present invention is directed to a pharmaceutical composition or dosage form having a stable, low (diluted) digestive en2yme content comprising at least one digestive enzyme and at least one carrier, or a dosage form thereof. The invention is also directed to a process of preparation of the composition or the dosage form. In addition the invention is directed to the treatment and prevention of disorders or conditions associated with a digestive enzyme deficiency in a patient in need thereof, comprising administering to said patient a pharmaceutically acceptable amount of the composition having a stable low digestive enzyme content or dosage form thereof.
Patent CA-2813549-A1 (CA)
Inventor: NISHIDA KATSUTOSHI
IPC: H04W36/12
Filed: 2011-10-04
Abstract: A mobile communication system of the present invention comprises: a process wherein a UE switches the connection destination wireless access network from E-UTRAN to UTRAN/GERAN; a process wherein an MME receives, from an S-GW, a Delete Bearer Request to an audio communication packet bearer; and a process wherein the MME, when a core-bearer cut-off flag is set within the received Delete Bearer Request, transmits, to the S-GW, a Delete Bearer Response in response to the Delete Bearer Request, without giving instructions, to UE #1 or the E-UTRAN, to release the audio communication packet bearer.
Patent CA-2817082-A1 (CA)
Inventor: VANKUYK PATRICIA ANN
IPC: C07K14/38
Filed: 2010-11-12
Abstract: The invention relates to the production of biofuels, proteins, peptides and other value-added compounds from crude carbon sources. The inventors identified genes encoding novel pentose transporters, in particular transporters of L-arabinose and/or D-xylose. Regulation of the Aspergillus niger genes by xlnR and araR was instrumental in the identification of these genes and their substrate specificities. Provided are novel pentose transporters and their encoding nucleic acids. Also provided are host cells (over)expressing a transporter, and industrial applications thereof, for instance in biofuel production.
Patent CA-2817582-A1 (CA)
Inventor: NGUYEN TUAN A
IPC: B21D51/44
Filed: 2011-11-17
Abstract: The present invention describes a beverage container end closure that utilizes less material and has improved internal buckle strength based on the geometric configuration of a chuck wall, inner panel wall, outer panel wall, and central panel and that utilizes an outwardly oriented countersink. Certain embodiments of said container end closure comprising: a peripheral curl adapted for interconnection to a container body side wall; a chuck wall interconnected to said peripheral curl and extending downwardly and inwardly at an angle; an outer panel wall interconnected to a lower portion of the chuck wall, said outer panel wall being angled; a countersink interconnected to a lower portion of said outer panel wall; an inner panel wall interconnected to said countersink and extending upwardly at an angle; and a central panel interconnected to an upper end of said inner panel wall and raised above a lowermost portion of said countersink.
Patent CA-2817600-A1 (CA)
Title: Composite communications cables having a fiber optic component located adjacent an outer surface of the central conductor of a coaxial cable component and related methods
Inventor: CHAMBERLAIN JOHN CHARLES
IPC: H01B11/22
Filed: 2013-06-04
Abstract: Composite communications cable are provided that include a central conductor, a dielectric spacer that substantially surrounds the central conductor, an outer conductor that substantially surrounds the dielectric spacer, a jacket that surrounds the outer conductor and a non-buffered optical fiber positioned between the central conductor and the dielectric spacer. An outer surface of the non-buffered optical fiber is within 50 microns of the outer surface of the central conductor. The positioning of the optical fiber adjacent an outer surface of the central conductor may protect the optical fiber from damage.
Patent CA-2817824-A1 (CA)
Title: User-activated self-contained co-packaged iontophoretic drug delivery system
Inventor: SEBREE TERRI B
IPC: A61N1/32
Filed: 2011-11-09
Abstract: A user-activated self-contained co-packaged iontophoretic drug delivery system and method of use for treatment of a subject are described.
Patent CA-2818451-A1 (CA)
Inventor: EL-BAKRY AMR S
IPC: G06G7/48
Filed: 2011-12-08
Abstract: Methods and systems are provided for generating a development plan for a hydrocarbon asset. A high-fidelity computer model of a hydrocarbon asset is created. A low-fidelity computer model of the hydrocarbon asset is created. The low-fidelity computer model is iterated on to an interim solution. A comparison is generated of the interim solution to a solution obtained from a simulation of the high-fidelity computer model at the variables of the interim solution. The low-fidelity computer model is calibrated based, at least in part, on the comparison. The development plan for the hydrocarbon asset is generated based, at least in part, on a result from the calibrated low-fidelity computer model. The low-fidelity computer model is a mixed-integer nonlinear programming problem with complementarity.
Patent CA-2822935-A1 (CA)
Title: Method and apparatus for attractive bonusing
Inventor: SMITH VINCENT P
IPC: A63F13/30
Filed: 2013-07-31
Abstract: A method for a game includes providing a plurality of individual gaming machines for playing a base game, where an outcome of each gaming machine is determined at least in part by chance, and communicatively coupling a progressive bonus apparatus to said plurality of individual gaming machines. The method includes creating value elements and inserting them onto individual gaming machines in a bank of gaming machines.  The value elements can be seen visually by players so that the players can monitor the status of the bonus game while playing the base game. Also disclosed is an apparatus capable of carrying out the above method as well as a media carrying an instruction set for carrying out the above method.
Patent CA-2825507-A1 (CA)
Inventor: BRIDGEMAN TODD CLEABERT
IPC: C22C5/08
Filed: 2013-08-29
Abstract: A platinum-free silver alloy may include about 0.1% to 0.9% Au, about 83% to 90% Ag, about 2% to 3% Pd, about 3% to 5% Zn, about 2% to 8% Cu, about 0.01% to 0.4%  B, about 0.1% to 0.3% Ge, and about 0.01% to 0.03% Ir.
Patent CA-2826708-A1 (CA)
Inventor: ROCKHILL TURNER
IPC: A61K31/201
Filed: 2013-09-10
Abstract: The subject invention is based upon the discovery that a wide variety of pharmaceutical agents can be delivered into the skin, fingernails, and toenails of patients by dissolving or dispersing the pharmaceutical agent in a solvent system which is comprised of a combination of an alkyl lactate and Simmondsia chinesis seed oil. It is critical for the solvent system to contain both the alkyl lactate and Simmondsia chinesis seed oil to attain penetration through skin, fingernails and toenails. In other words, for effective delivery of the pharmaceutical agent through the skin or nail it is critical for the pharmaceutical agent to be dissolved or dispersed in a mixture of an alkyl lactate and Simmondsia chinesis seed oil. The subject invention more specifically discloses a pharmaceutical serum which is comprised of (1) an alkyl lactate, wherein the alkyl group in the alkyl lactate contains from 2 to about 12 carbon atoms, (2) Simmondsia chinesis seed oil, and (3) a pharmaceutical agent. Some representative examples of pharmaceutical agent which can be incorporated into the pharmaceutical serums of this invention include, antifungal agents, hormones, growth factors (cytokines), antimicrobials, antibacterials, antibiotics, non-steroidal anti-inflammatory agents, immunodilators, anesthetics, plant extracts, vitamins, corticosteroids, hair growth stimulants, and the like.
Patent CA-2827989-A1 (CA)
Title: Fluid drilling head nozzle design
Inventor: ADAM SCOTT CHRISTOPHER
IPC: E21B7/18
Filed: 2012-02-23
Abstract: A fluid cutting head (8) of the type having a plurality of nozzles in a rotatable nozzle assembly (9) for cutting a bore hole in rock, has nozzles being arranged to be supplied with high pressure drilling fluid, forming jets positioned to cut adjacent rock. The nozzles include one or more generally axially facing pilot nozzles (1 and 2) and one or more generally radially facing reaming nozzles (3, 4, 5 and 6), at least the pilot nozzles being characterised by a non-tapering outlet section such that the jet issuing therefrom is of substantially constant cross-section in a zone immediately adjacent the outlet section. The pilot nozzles are located in a leading part (26) of the rotatable nozzle assembly (9), having a minimised diameter, while the reaming nozzles are located in the following part (27) of the rotatable nozzle assembly (9), formed in a step-wise fashion to keep the reaming nozzles close to the rock face.
Patent CA-2828106-A1 (CA)
Inventor: GILES KEVIN
IPC: H01J49/42
Filed: 2012-02-24
Abstract: A non-linear ion guide is disclosed comprising a plurality of electrodes (6). An ion guiding region is arranged between the electrodes (6), and the ion guiding region curves at least in a first (x) direction. A DC voltage is applied to at least some of the electrodes (6) in order to form a DC potential well which acts to confine ions within the ion guiding region in the first (x) direction.
Patent CA-2830633-A1 (CA)
Title: Transmission de la longueur d'un element de trame dans le codage audio
Inventor: NEUENDORF MAX
IPC: G10L19/008
Filed: 2012-03-19
Abstract: Selon l'invention, des éléments de trame qui doivent pouvoir être omis peuvent être transmis plus efficacement en ce qu'une information de longueur de la charge utile est transmise séparément à l'intérieur d'un bloc de configuration, l'information de longueur à l'intérieur des éléments de trame étant à son tour subdivisée en un fanion de longueur de charge utile par défaut suivi, si le fanion de longueur de charge utile par défaut n'est pas défini, par une valeur de longueur de charge utile codant explicitement la longueur de la charge utile de l'élément de trame correspondant. Toutefois, si le fanion de longueur de charge utile par défaut est défini, une transmission explicite de la longueur de la charge utile peut être évitée. Au lieu de cela, tout élément de trame dont le fanion de longueur de charge utile d'extension par défaut est défini présente la longueur de charge utile par défaut et tout élément de trame dont la fanion de longueur de charge utile d'extension n'est pas défini présente une longueur de charge utile correspondant à la valeur de la longueur de la charge utile. Cette disposition permet d'accroître l'efficacité de la transmission.
Patent CA-2833764-A1 (CA)
Title: Fermentation methods to produce kvass, kombucha and vegetable extracts using a consortium of microorganisms
Inventor: SKRIPITSYNA MARIYA ANDREEVNA
IPC: A23L19/00
Filed: 2012-04-18
Abstract: The invention relates to bioengineering and the foods industry and relates to consortia of microorganisms and strains of bacteria and yeasts, and is directed to methods for producing a fermented base in the form of a semifinished product of bread kvass, fermentation kvass and alcohol-free kvass in a single process cycle with the aid of consortia and strains of bacteria and yeasts as well as to methods for producing a liquid kombucha culture, kombucha concentrates and kombucha drinks and vegetable extracts in a single process cycle.
Patent CA-2833915-A1 (CA)
Inventor: BALTES CHRISTIAN
IPC: C07C45/38
Filed: 2012-04-19
Abstract: A process for preparing C1-C10-aldehydes by oxidative dehydrogenation of C1-C10-alcohols over a shaped catalyst body obtainable by three-dimensional forming and/or arrangement in the space of silver-containing fibres and/or filaments, characterized in that the mean diameter or the mean diagonal length of an essentially rectangular or square cross section of these silver-containing fibres and/or filaments is in the range from 30 µm to 200 µm.
Patent CA-2837838-A1 (CA)
Inventor: NISHIMURA HIDETAKA
IPC: H01M8/04
Filed: 2012-04-17
Abstract: A fuel cell system that generates electric power by supplying anode gas and cathode gas to a fuel cell includes a control valve adapted to control the pressure of the anode gas to be supplied to the fuel cell; a buffer unit adapted to store the anode-off gas to be discharged from the fuel cell; a pulsation operation unit adapted to control the control valve in order to periodically increase and decrease the pressure of the anode gas at a specific width of the pulsation; and a pulsation width correcting unit adapted to correct the width of the pulsation on the basis of the temperature of the buffer unit.
Patent CA-2838198-A1 (CA)
Inventor: IDDON LISA
IPC: B01D3/00
Filed: 2012-06-07
Abstract: A click chemistry process to be performed with an automated synthesis device using a synthesis cassette includes the steps of performing a chemical reaction in a first vessel at a first elevated temperature, heating the first vessel to a second elevated temperature to cause distillation, delivering a distilled reaction product from the first vessel to a second vessel, performing a click chemistry reaction with the distilled reaction product in the second vessel, purifying the click chemistry product, and formulating a final product from the purified click chemistry product. A cassette and a kit of parts for performing the process are also provided.