baber/WOPTO huggingface dataset:
Patent ES-2294187-T3 (ES)
Title: Derivados benzotiazol de nicotina o isonicotina.
Inventor: FLOHR ALEXANDER
IPC: A61P9/00
Filed: 2002-11-11
Granted: 2008-04-01
Abstract: Los compuestos de fórmula general IA o IB en donde R1 es fenilo, piperidin-1-ilo o morfolinilo; A es -O- y R es -(CH2)n-N(R'''')-C(O)-alquilo inferior, -(CH2)n-O-alquilo inferior, -(CH2)n-O-(CH2)n-O-alquilo inferior, alquilo inferior, -(CH2)n-morfolinilo, -(CH2)n-fenilo, -(CH2)n-N(R'''')2, -(CH2)n-piridinilo, -(CH2)n-CF3, -(CH2)n-2-oxo-pirrolidinilo o C4-6-cicloalquilo; R'''' es independientemente uno del otro hidrógeno o alquilo inferior y n es 1 ó 2; o A es -N(R'')- y R es alquilo inferior, C4-6-cicloalquilo, -(CH2)n-O-alquilo inferior, -(CH2)n-piridinilo, -(CH2)n-piperidinilo, -(CH2)n-fenilo, -(CH2)n-N(R'''')-C(O)-alquilo inferior, -(CH2)n-morfolinilo, o -(CH2)n-N(R'''')2; R'' y R'''' son independientemente uno del otro hidrógeno o alquilo inferior y n es 1 ó 2; ó A es -CH2- y R es -N(R'''')-(C2)m-O-alquilo inferior, -N(R'''')2, -S-alquilo inferior o es acetidinilo, pirrolidinilo o piperidinilo, que están opcionalmente sustituidos con hidroxilo o alcoxilo inferior o es morfolinilo, -N(R'''')-(C2)m-C4-6-cicloalquilo, -N(R'''')-(CH2)m- C(O)O-alquilo inferior, -N(R'''')-(CH2)m-C(O)OH, -2-oxo-pirrolidinilo, -N(R'''')-C(O)O-alquilo inferior, -O(C2)m-O-alquilo inferior o alcoxilo; R'''' es independientemente uno del otro hidrógeno o alquilo inferior y m es 1, 2 ó 3; o A es -S- y R es alquilo inferior; o A-R son juntos
Patent ES-2242100-T3 (ES)
Inventor: AMTMANN EBERHARD
IPC: A61P31/18
Filed: 2002-11-02
Granted: 2005-11-01
Abstract: The invention relates to pharmaceutical formulations containing exo/exo-tricyclo[5.2.1.02.6]-dec-9-yl-xanthogenate, drugs containing exo/exo-tricyclo[5.2.1.02.6]-dec-9-yl-xanthogenate as active ingredient for the treatment of genital herpes, labial herpes, AIDS, tumors or autoimmune diseases, and methods for the production of pure stereoisomers of tricyclo[5.2.1.02.6]-decan-9-ol and tricyclo[5.2.1.02.6]-dec-9-yl-xanthogenate.
Patent ES-2332585-T3 (ES)
Inventor: FUMAGALLI DANIELE
IPC: E04H17/16
Filed: 2003-06-16
Granted: 2010-02-09
Abstract: An adjusting unit (16) varies the heights at which panels (2a,2b) are fixed to pedestals. U-shaped elements are composed of parallel sleeves (13,14) having square cross-sections and telescopically inserted into corresponding lateral posts (7,8).
Patent ES-2291621-T3 (ES)
Inventor: NISSEN VIBEKE
IPC: A23G4/00
Filed: 2003-02-04
Granted: 2008-03-01
Abstract: The invention relates to a chewing gum tablet (10, 20, 30, 40, 50) comprising at least three separate cohered chewing gum modules (11, 12; 21, 22, 23; 31, 32; 41, 42; 51, 52) 
at least one of said chewing gum modules comprising compressed gum base containing chewing gum granules, said module forming an intermediate gum base containing layer, and 
wherein the chewing gum tablet comprises a gum base content of at least 5% by weight of the tablet, and 
at least one of said three chewing gum modules is substantially free of gum base.
Patent ES-2263005-T3 (ES)
Title: Brazo de suspension para vehiculo a motor.
Inventor: IZQUIERDO NUNEZ JOSE RAMON
IPC: B60G7/00
Filed: 2003-07-07
Granted: 2006-12-01
Abstract: Incorpora un cuerpo (1) conformado en chapa por embutición con reducido espesor y máxima inercia, y consiste en un elemento modular listo para montar que integra: una rótula (2) situada en el interior de un alojamiento frontal exterior (5) en el que se encuentra acoplada por medio de una cazoleta inferior (6) y una tapa (7) que encajan y se sueldan por láser, un silentblock frontal (3) que muestra un cuerpo cilíndrico desde cuya superficie se prolongan radialmente unas parejas de patillas de amarre (11) que se insertan en una ranura (8) definida en un alojamiento frontal (9) curvo cóncavo se pliegan y se sueldan por soldadura láser, y un silentblock trasero (4) que se encuentra incorporado en un alojamiento posterior (12) por medio de unos casquillos (15) enchufados a presión.
Patent ES-2354067-T3 (ES)
Inventor: LAUTERBACH FOLKER
IPC: G03B17/02
Filed: 2003-03-22
Granted: 2011-03-09
Abstract: The invention relates to a protective housing for a camera, comprising a plurality of walls which form two annular chambers. A thermal insulation medium is arranged inside an outer annular chamber and a thermal acculumator medium is arranged inside the inner chamber. Disks are introduced in a gastight manner in the front plates.
Patent ES-2350097-T3 (ES)
Title: Procedimiento para reutilizar un producto de resina sintética triturada.
Inventor: SUZUKI YOSHIKI
IPC: C08J3/20
Filed: 2003-04-11
Granted: 2011-01-18
Abstract: Un procedimiento para producir partículas coloreadas de resina regenerada que comprende las etapas de: preparar un producto fundido que comprende una mezcla de pigmento blanco, un pigmento coloreado y un producto de resina termoplástica pulverizada carente de película de revestimiento para su regeneración que se selecciona del grupo constituido por un producto termoplástico pulverizado que contiene un pigmento negro, una mezcla de un producto termoplástico pulverizado que contiene un pigmento negro y un producto termoplástico pulverizado que contiene un pigmento coloreado, y un producto termoplástico pulverizado que contiene dos o más pigmentos coloreados diferentes; y convertir el producto fundido en partículas sólidas.
Patent ES-2316808-T3 (ES)
Title: Empleo de dihidroimidazolonas para el tratamiento de la epilepsia en perros.
Inventor: RUNDFELDT CHRIS
IPC: A61K31/515
Filed: 2003-10-09
Granted: 2009-04-16
Abstract: Empleo de la 1-(4-clorofenil)-4-(4-morfolinil)-2,5-dihidro-1H-imidazol-2-ona, ó una sal fisiológicamente aceptable de la misma como ingrediente activo para la fabricación de un medicamento para el tratamiento de la epilepsia idiopática en perros.
Patent ES-2321927-T3 (ES)
Inventor: VACHER BERNARD
IPC: A61K31/4545
Filed: 2003-06-18
Granted: 2009-06-15
Abstract: 1-Benzoyl-4-(N-(heteroarylmethyl)-aminomethyl)-piperidine derivatives (I) are new.  Piperidine derivatives of formula (I) and their tautomers and optionally hydrated addition salts with mineral or organic acids are new.  X, Y = CH or N; A = Me, CH2F, CN, OH, OMe, Cl or F; G = Cl or F; D = H, Cl, F, CN or CF3; and E = H, F or Cl;  Provided that if A = Me and X = Y = CH, then G is Cl.
Patent ES-2289337-T3 (ES)
Inventor: PEREZ ALVAREZ MARTA
IPC: A61K31/35
Filed: 2003-07-30
Granted: 2008-02-01
Abstract: Compounds of the general formula (I) or a pharmaceutically acceptable salt, derivative, prodrug or stereoisomer thereof are provided: wherein the substituent groups defined by R are each independently selected from the group consisting of H, SiR'3, SOR', SO2X, C(-O)R', C(-O)OR', C(-O)NR', substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, aryl, heteroaryl or aralkyl; the group R' is selected from substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, aminoalkyl, aryl, aralkyl and heterocyclic groups; and the group R'' is selected from the group consisting of H, OH, OR', OCOR', SH, SR', SOR', SO2R', NO2, NH2, NHR', N(R')2, NHCOR', N(COR')2, NHSO2R', CN, halogen, C(-O)H, C(-O)R', CO2H, CO2R', CH2OR, substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkylidene, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and substituted or unsubstituted heteroaromatic; with the proviso that the compound is not compound 1, 3 or 4 of U.S. Pat. No. 5,514,708. The compounds have antitumour activity. A synthetic route is also provided.
Patent ES-2257706-T3 (ES)
Inventor: BELMONT DANIEL THOMAS
IPC: C07D315/00
Filed: 2003-08-18
Granted: 2006-08-01
Abstract: A process for preparing functionalized gamma-butyrolactones 3 and various biologically active compounds using mucohalic acid 1 and halide 2 in the presence of indium is disclosed, wherein X, Y, R<SUB>1</SUB>, R<SUB>2</SUB>, and R<SUB>3 </SUB>may have any of the meanings defined herein
Patent ES-2366208-T3 (ES)
Inventor: BARTHOLOMAE MARIO
IPC: H01R13/506
Filed: 2003-09-02
Granted: 2011-10-18
Abstract: A cable connection ( 1 ) for connecting a cable ( 2 ) on a housing or a wall is provided. The cable connection includes a threaded bushing ( 3 ) in which the connection contacts ( 4 ) are arranged, and a conductor compartment ( 5 ), which in a use position, holds conductors ( 2 a) or wires of the cable ( 2 ) to be to be connected, with the conductors coming to rest against the contacts ( 4 ) after insertion of the conductor compartment ( 5 ) into the threaded bushing ( 3 ). The connection also includes a clamping insert ( 7 ) that surrounds the cable ( 2 ) and lies axially adjacent to the conductor compartment ( 5 ), fixing the cable in an axial direction in the threaded bushing ( 3 ), and a cap nut ( 6 ) that is screwed onto the threaded bushing ( 3 ) for simultaneous radial deformation of the clamping insert ( 7 ) and fixing of the cable ( 2 ) in a final position of use. The conductor compartment ( 5 ) and the cap nut ( 6 ) are separate and can be attached to the threaded bushing ( 3 ) one after the other and a snap-in connection for axial fixing of the conductor compartment ( 5 ) is provided on the threaded bushing ( 3 ) for axially securing the conductor compartment ( 5 ) in the contact position.
Patent ES-2589560-T3 (ES)
Title: Circuito de control electrónico y método de monitorización  del funcionamiento de triacs
Inventor: OUDART PASCAL
IPC: H02H7/085
Filed: 2003-12-26
Granted: 2016-11-15
Abstract: Circuito de control electrónico que comprende al menos un triac (TC1, TC2, TC3), caracterizado porque una resistencia (R10) se dispone en serie con dicho triac (TC1, TC2, TC3) y los medios que forman un filtro paso bajo (2) están adaptados para medir la componente continua de la corriente que circula en dicha resistencia (R10).
Patent ES-2298630-T3 (ES)
Title: Composicion coadyuvante del aclarado que contiene una sal metalica soluble en agua para uso en el lavado automatico de vajillas para la proteccion de la corrosion de los metales y la formacion de oxido.
Inventor: SONG BRIAN XIAOQING
IPC: C11D3/00
Filed: 2003-12-19
Granted: 2008-05-16
Abstract: Una composición coadyuvante del aclarado para reducir la corrosión de material de vidrio caracterizada por comprender: a) de 0, 01% a 70% en peso de al menos una sal de metal soluble en agua, en donde dicha al menos una sal de metal soluble en agua comprende cinc y en donde dicha sal de cinc soluble en agua se selecciona del grupo que consiste en acetato de cinc, cloruro de cinc, gluconato de cinc, formiato de cinc, malato de cinc, nitrato de cinc, sulfato de cinc y mezclas de las mismas; b) de 0, 01% a 25% en peso de un ácido; c) de 0, 01% a 60% en peso de un tensioactivo no iónico; d) al menos uno de los siguientes: un polímero dispersante, un perfume y mezclas de los mismos; y e) de forma opcional, al menos un componente seleccionado del grupo que consiste en ácido, polímero dispersante, perfume, hidrótropo, aglutinante, medio portador, sustancia activa antibacteriana, tinte y mezclas de los mismos; en donde dicha composición coadyuvante del aclarado tiene un pH de menos de 5 medido a una concentración del 10% en una solución acuosa.
Patent ES-2357744-T3 (ES)
Inventor: GROLL WILLIAM
IPC: A47J36/02
Filed: 2003-08-13
Granted: 2011-04-29
Abstract: Cookware having improved uniform heat transfer over the entire cross section thereof, the cookware formed from a multi-layered composite metal (20) having a layer (40) of titanium or other metal having a lower coefficient of thermal conductivity than that of the adjacent layers at or near the core of the composite. The titanium layer is roll bonded to layers (60), (60') of aluminum which, in turn, is roll bonded to layers (70), (70') of stainless steel. The layer of stainless steel adjacent to the cooking range may be a ferritic stainless steel if induction-type heating is desired. The multi-layered composite is also suitable for making a sole plate for an iron. Both the cookware and sole plate may include a non-stick surface (90) applied thereto.
Patent ES-2234457-T3 (ES)
Title: Unidad de recogida de polvo con conjunto de filtro para aspiradora.
Inventor: LEE YUN-SEOK
IPC: A47L9/12
Filed: 2004-06-03
Granted: 2009-05-01
Abstract: Un conjunto (40) de filtro para una aspiradora, comprendiendo: - un filtro (82; 92) primario para separar por filtración polvo fino contenido en el aire; - un receptáculo (81; 91) de filtro con el filtro (82;92) primario fijado a una periferia externa del mismo y una pluralidad de orificios respiro de aire formados sobre la periferia externa del mismo; y - un filtro (83;93) secundario montado dentro del receptáculo (81; 91) de filtro para separar de nuevo por filtración el fino polvo contenido en el aire que ha pasado a través del filtro (82; 92) primario.
Patent ES-2351599-T3 (ES)
Title: Uso de ésteres de ácidos grasos y dioles dímeros.
Inventor: KAWA ROLF
IPC: A61K8/06
Filed: 2004-10-02
Granted: 2011-02-08
Abstract: Uso de Ésteres de ácido graso dímero y diol para mejorar la resistencia al agua de preparaciones cosméticas y/o farmacéuticas.
Patent ES-2359064-T3 (ES)
Inventor: RICO JARABO CARLOS
IPC: E06B1/02
Filed: 2004-07-08
Granted: 2011-05-18
Abstract: A fixing device for fixing frames to pre-frames, comprising an angular profile (1) at a right angle, wherein one (2) of its walls has a series of openings (3) along the length thereof for the passage of screws which can be screwed to the frame, whereas the other wall (6), which supports the profile of the pre-frame, is provided with transverse notches (7) after its free edge for the passage of screws which can be screwed to the pre-frame for the purpose of adjusting said fixing; the notches (7) having conical recesses on their external side for receiving the head of the screws, and supporting projections (8) on their internal side, the wall (6) being furthermore provided with a longitudinal step on its free edge defining a side area (9), whereas on its external surface, the wall (2) has, supporting ribs (4) for supporting it against the frame, and reinforcing ribs (5) on its internal surface. <IMAGE>
Patent ES-2297397-T3 (ES)
Inventor: OHLIG BENEDIKT
IPC: B60T8/40
Filed: 2004-03-10
Granted: 2008-05-01
Abstract: A braking force generator includes a primary piston displaceable in a housing to enclose a primary pressure chamber. A pedal simulation device is connected to the force input element. A pedal actuation detection device detects the pedal actuation and an actuating force booster stage. During normal operation the force input element is mechanically uncoupled from the primary piston, and the actuating force booster stage exerts an actuating force on the primary piston. In the event of failure of the actuating force booster stage the force input element is workingly connectable to the primary piston such that a contact extension extends from the primary piston towards the force input element. During normal operation the contact extension is held by a release gap at a distance from the force input element and in the event of failure of the actuating force booster stage the force input element after travelling the release gap is applied workingly against the contact extension.
Patent ES-2341771-T3 (ES)
Inventor: ITO TATSUO
IPC: A61K38/00
Filed: 2004-06-25
Granted: 2010-06-28
Abstract: A compound of formula I:   
a thiol form of the compound of formula I having a reduced S-S bond, a pharmaceutically acceptable salt of the compound of formula I, a hydrate of the compound of formula I, an anhydrous form of the compound of formula I, an acetylated form of the compound of formula I, a stereoisomer of the compound of formula I, or a mixture of said stereoisomers, for use in treatment of malignant fibrous histocytoma, liposarcoma, rhabdomyosarcoma, leiomyosarcoma, fibrosarcoma, malignant schwannoma, angiosarcoma or clear cell sarcoma.
Patent ES-2708822-T3 (ES)
Title: Estimación de interferencia y ruido en un sistema OFDM
Inventor: SUTIVONG ARAK
IPC: G01H1/00
Filed: 2004-05-14
Granted: 2019-04-11
Abstract: Un procedimiento para estimar el ruido en un sistema de multiplexación por división de frecuencia ortogonal, OFDM, (200), el procedimiento que comprende: recibir símbolos OFDM; detectar una potencia recibida de una señal en una banda de frecuencias de subportadora no asignada; y caracterizado por: calcular un promedio ponderado de la potencia recibida con al menos una medición de potencia recibida almacenada previamente para la banda de frecuencias de subportadora no asignada, en el que una ponderación para el promedio ponderado se basa en una antigüedad de al menos una medición de potencia recibida almacenada previamente.
Patent ES-2289549-T3 (ES)
Inventor: KRAMER ANDREAS
IPC: C09J175/04
Filed: 2004-07-16
Granted: 2008-02-01
Abstract: Epoxy resin composition containing an epoxide-terminated polymer with urethane groups which also contains at least one aromatic structural element linked to the polymer chain by urethane groups. Compositions containing (A) epoxide adduct(s) with more than 1 epoxide group, (B) polymer(s) of formula (I) with at least one aromatic structural element which is linked to the polymer chain by urethane groups, (C) thixotropy modifier(s) based on urea derivatives, in a non-diffusing carrier material and (D) heat-activated epoxy resin hardener(s). [Image] Y 1an n-valent residue of an isocyanate-terminated linear or branched polyurethane prepolymer (after removing the terminal NCO groups); Y 2a residue of an aliphatic, cycloaliphatic, aromatic or araliphatic epoxide with a prim. or sec. hydroxyl group (after removing the OH and epoxide groups); m : 1, 2 or 3; n : 2, 3 or 4. Independent claims are also included for: (1) epoxide group-terminated impact modifiers of formula (I) (2) a method for bonding heat-stable materials, especially metals, with a composition as defined above which is then hardened at 100-220 (preferably 120-200) [deg] C.
Patent ES-2279432-T3 (ES)
Inventor: NEUMANN CHRISTIAN
IPC: B01F25/60
Filed: 2004-07-01
Granted: 2007-08-16
Abstract: A rigid tank (1), containing a generally-rectangular, disposable pocket (2), is new. Its (2) upper and lower surfaces are permanently connected by a mixing line (3) passing through a dedicated, non-intrusive pump (4) (an external peristaltic pump is shown). This circulates liquid from low in the pocket, to its top. The pump can be opened and closed, allowing the mixing line to be inserted into it, or removed from it. An independent claim is included for the corresponding method of mixing.
Patent ES-2314442-T3 (ES)
Inventor: BUSHBY ROGER STANLEY
IPC: C22C47/12
Filed: 2004-08-12
Granted: 2009-03-16
Abstract: A method of pressure forming a metal matrix composite (MMC), comprises: placing a fiber preform (not shown) into a die cavity (14) defined by a split die (12); introducing molten metal into the die cavity (14) through a sprue (16) to envelope the fiber preform; sealing the sprue (16); applying pressure direct to molten metal in the die cavity (14) with a mechanical compaction piston (18) to encourage infiltration of the fiber preform during solidification.
Patent ES-2336450-T3 (ES)
Inventor: MEHTA JAY L
IPC: A61K31/4184
Filed: 2004-09-22
Granted: 2010-04-13
Abstract: A combination comprising candesartan and rosuvastatin for the prevention or treatment of arteriosclerosis and for the prevention of cardiovascular events is described.
Patent ES-2619176-T3 (ES)
Title: Biocatalizador para producir ácido D-láctico
Inventor: WADA MITSUFUMI
IPC: C12N1/21
Filed: 2004-09-17
Granted: 2017-06-23
Abstract: Un microorganismo recombinante en el que la actividad de D-lactato deshidrogenasa dependiente de FAD (did) inherente en el microorganismo recombinante esta inactivada o reducida, la actividad de piruvato formiato-liasa (pfl) esta inactivada o reducida y la actividad de D-lactato deshidrogenasa dependiente de NADH derivada de Escherichia coli (ldhA) esta potenciada.
Patent ES-2611754-T3 (ES)
Title: Máquina de piruletas
Inventor: ASMA SEFERINUS
IPC: A23G7/02
Filed: 2004-11-03
Granted: 2017-05-10
Abstract: Dispositivo para fabricar piruletas, que comprende un bastidor y un tambor (3) accionado giratorio provisto con moldes de piruletas (40) en su circunferencia, un suministro para suministrar una colada de material de piruletas a los moldes de piruletas y una descarga para las piruletas formadas en los moldes de piruletas, en el que el tambor está dispuesto sobre un árbol hueco (12) y en el que los moldes de piruletas están dispuestos en la circunferencia de una carcasa (10), que define un espacio anular con el árbol hueco, en el que los moldes de piruletas comprenden, por ejemplo moldes inferiores que son sólidos con la carcasa y moldes superiores que están articulados a los moldes inferiores, en el que el árbol hueco está provisto con un primer paso (16, 17) y un segundo paso (16, 17), cada uno de los cuales forma una conexión de fluido entre la cavidad en el árbol hueco y el espacio anular, en el que el árbol hueco está provisto con un suministro de fluido y una descarga de fluido, cuyo suministro de fluido está en conexión de fluido con una fuente de presión para aire de refrigeración, en el que el árbol hueco es estacionario y sobre el que están previstos cojinetes para la carcasa, en el que la carcasa se puede separar del árbol hueco y el árbol hueco está fijado sobre el bastidor.
Patent ES-2386677-T3 (ES)
Inventor: BREUER OLIVER
IPC: A43C7/08
Filed: 2004-11-29
Granted: 2012-08-24
Abstract: Clamping device (1) for shoelaces (2) or the like lacing devices with clamping jaws, between which the shoelace (2) can be locked in a closed position and moved back and forth in an open position, wherein the clamping device (1) is engageable in an open position wherein the engagement in an open position of the clamping device (1) is releasably by a movement of the shoelace (2) to be locked in a direction out of the pulling direction of the shoelace (2) as well as a shoe with a clamping device (1) in accordance to the invention.
Patent ES-2394210-T3 (ES)
Title: Sistema de conexión para motores eléctricos
Inventor: BOTE SALLA RAMON
IPC: H02K3/47
Filed: 2005-04-22
Granted: 2013-01-23
Abstract: Un método de conexión del estator (4) de un motor eléctrico a una pieza de conexión (4) hecha mediante unmaterial eléctricamente conductor, que comprende "n" piezas individuales (4') cada una con una salida del cable (6)y "n-1" cortes (5) entre las mencionadas piezas individuales (4'), en donde las mencionadas piezas individuales (4')están unidas conjuntamente mediante piezas de reposición (7) del mismo material eléctricamente conductor,comprendiendo las siguientes etapas:· Conexión de los "n" extremos de los devanados a las "n" salidas (6) de los cables de las mencionadas "n" piezasindividuales (4') de la pieza de conexión (4).· Encapsulado de la pieza de conexión (4) con el estator, de forma que la resina pueda rellenar también los "n-1"cortes (5);
Patent ES-2297587-T3 (ES)
Inventor: MERSMANN MARKUS
IPC: F27B14/20
Filed: 2005-10-11
Granted: 2008-05-01
Abstract: A contactless melting oven crucible (2) temperature measurement unit has a pyrometer (5) with sensor (6) using optics aimed at part of the crucible by a sample glass (18) connected to the upper end of a tube extending (22) into the oven melt zone (11).
Patent ES-2296050-T3 (ES)
Inventor: RASMUSSEN JON H
IPC: C07K5/087
Filed: 2002-12-23
Granted: 2008-04-16
Abstract: The invention relates to a process for preparing a tripeptide, including a salt thereof, of the formula (IX) 
Boc-D-2Nal-D-4CIPhe-D-3Pal-OH (IX) 
comprising the following consecutive steps:  (a) Reacting Boc-D-4ClPhe-OH with HONSu to form Boc-D-4ClPhe-OSu (VII);  (b) Reacting Boc-D-4ClPhe-OSu (VII) with H-D-3Pal-OH to form Boc-D-4ClPhe-D-3Pal-OH (VIII);  (c) Reacting Boc-D-4ClPhe-D-3Pal-OH (VIII) with Boc-D-2Nal-OSu prepared by reacting Boc-D-2Nal-OH with HONSu to form Boc-D-2Nal-D-4ClPhe-D-3Pal-OH (IX).