Patent SG-11201808627R-A (SG)
Title: Novel peptides and combination of peptides for use in immunotherapy against aml and other cancers
Inventor: MAHR ANDREA
IPC: C07K7/08
Filed: 2017-04-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111110111101110101011111 HO 11111 0111010111011110011111011111011110111111 International Bureau .. .... ..Yejd ..... .....!;,,, (10) International Publication Number (43) International Publication Date WO 2017/174645 Al 12 October 2017(12.10.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07K 7/06 (2006.01) C07K 14/00 (2006.01) kind of national protection available): AE, AG, AL, AM, C07K 7/08 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/EP2017/058083 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 5 April 2017 (05.04.2017) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 62/319,141 6 April 2016 (06.04.2016) US (84) Designated States (unless otherwise indicated, for every 1605872.9 6 April 2016 (06.04.2016) GB kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: IMMATICS BIOTECHNOLOGIES GMBH TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, [DE/DE]; Paul-Ehrlich-Strasse 15, 72076 Tithingen (DE). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (72) Inventors: MAHR, Andrea; Kirschenweg 22, 72076 DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Tubingen (DE). WEINSCHENK, Toni; Im Morgenrain LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, 15, 73773 Aichwald (DE). WIEBE, Anita; QuellenstraBe GW, KM, ML, MR, NE, SN, TD, TG). 49, 72124 Ruebgarten (DE). SCHOOR, Oliver; Eich- haldenstrasse 19, 72074 Tithingen (DE). FRITSCHE, Published: Jens; Larchenweg 11, 72144 Dusslingen (DE). SINGH, — with international search report (Art. 21(3)) Harpreet; 5122 Morningside Dr, Apt. 525, Houston, — before the expiration of the time limit for amending the Texas 77005 (US). claims and to be republished in the event of receipt of (74) Agent: KRAUSS, Jan, B.; BOEHMERT & BOEHMERT, = amendments (Rule 48.2(h)) Pettenkoferstrasse 20-22, 80336 Munich (DE). — with sequence listing part of description (Rule 5.2(a)) 1-1 ir) 1 1' 1 1' IN (54) Title: NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST AML AND - OTHER CANCERS N (57) : The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In 1-1 C particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor- associ- ei ated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active phar - 0 maceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and ,-t transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.