Patent SG-11201805685P-A (SG)
Title: Substituted thiohydantoin derivatives as androgen receptor antagonists
Inventor: CONNOLLY PETER J
IPC: A61K31/4439
Filed: 2017-01-10
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111101111011101 01011111010111110 III 011111111011110011111011111111111110111111 International Bureau 0.. .... .. ...... ../ (10) International Publication Number (43) International Publication Date WO 2017/123542 Al 20 July 2017 (20.07.2017) WIPO I PCT (51) International Patent Classification: 66 John Dyer Way, Doylestown, Pennsylvania 18902-9607 C07D 401/14 (2006.01) CO7D 451/06 (2006.01) (US). MEERPOEL, Lieven; Turnhoutseweg 30, 2340 CO7D 405/14 (2006.01) CO7D 487/04 (2006.01) Beerse (BE). PANDE, Vineet; Turnhoutseweg 30, 2340 CO7D 413/14 (2006.01) CO7D 491/044 (2006.01) Beerse (BE). ZHANG, Zhuming; 1400 McKean Road, CO7D 401/04 (2006.01) CO7D 491/048 (2006.01) Spring House, Pennsylvania 19477 (US). BRANCH, CO7D 409/14 (2006.01) A61K 31/4439 (2006.01) Jonathan; 1400 McKean Road, Spring House, CO7D 451/02 (2006.01) A61P 35/00 (2006.01) Pennsylvania 19477 (US). ROCABOY, Christian; Parque Tecnologico de Fuente Alamo., Ctra. El Es- (21) International Application Number: trecho-Lobosillo,Km. 2,5 — Av., E-30320 El Es- PCT/US2017/012844 trecho-Lobosillo Murcia (ES). TRABALON ESCOLAR, (22) International Filing Date: Luis B.; Parque Tecnologico de Fuente Alamo., Ctra. El 10 January 2017 (10.01.2017) Estrecho-Lobosillo Km. 2,5 — Av., E-30320 El Es- trecho-Lobosillo Murcia (ES). (25) Filing Language: English (74) Agents: TRACY, Timothy E. et al.; JOHNSON & JOHN- (26) Publication Language: English SON, One Johnson & Johnson Plaza, New Brunswick, (30) Priority Data: New Jersey 08933 (US). 62/277,009 11 January 2016 (11.01.2016) US (81) Designated States (unless otherwise indicated, for every 62/363,534 18 July 2016 (18.07.2016) US kind of national protection available): AE, AG, AL, AM, (71) Applicant: JANSSEN PHARMACEUTICA NV AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, [BE/BE]; Turnhoutseweg 30, 2340 BEERSE (BE). BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, — DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (72) Inventor; and HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, = (71) Applicant (for US only): BIGNAN, Gilles [US/US]; 1400 KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, McKean Road, Spring House, Pennsylvania 19477 (US). MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, = — (72) Inventors: CONNOLLY, Peter J.; 1400 McKean Road, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, — Spring House, Pennsylvania 19477 (US). HICKSON, Ian; RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, = [Continued on next page] = (54) Title: SUBSTITUTED _= - 'N....I = = = = ,-, . 4 N () I ii- kin M ei ,-1 IN ,-1 O ei I NC mula THIOHYDANTOIN N DERIVATIVES AS ANDROGEN RECEPTOR ANTAGONISTS (57) : Disclosed are compounds, composi- tions and methods for treating of disorders that are af- fected by the antagonism of one or more androgen re- ceptor types. Such compounds are represented by For- (I) as follows: Formula (I) wherein R 1 and G are defined herein. N-G O WO 2017/123542 All#1101MOHIMIIMME301101110MINEHMOVOIS TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, VN, ZA, ZM, ZW. GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (84) Designated States (unless otherwise indicated, for every Published: kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, — with international search report (Art. 21(3)) before the expiration of the time limit for amending the TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of