baber/WOPTO huggingface dataset:
Patent CR-20160261-A (CR)
Title: Sistema de administración farmacológico
Inventor: DE GRAAFF WOUTER;
IPC: A61K47/32
Filed: 2014-12-08
Abstract: En el presente documento se describe un sistema de administración farmacológico intravaginal que comprende (i) un núcleo que comprende un primer polímero termoplástico y un primer agente terapéutico, en el que el primer agente terapéutico se disuelve en el primer polímero termoplástico , y (ii) una capa externa que rodea el núcleo que comprende un segundo polímero termoplástico, en el que el primer agente terapéutico es menos permeable en el segundo polímero termoplástico que el primer polímero termoplástico, y un segundo agente terapéutico en forma sólida, en el que el segundo agente terapéutico está cargado en una porción de la capa externa.
Patent CR-20170143-A (CR)
Title: Moléculas de anticuerpo que se unen a pd-l1 y usos de las mismas
Inventor: FREY GERHARD JOHANN
IPC: C07K16/46
Filed: 2015-10-13
Abstract: Se divulgan moléculas de anticuerpo que se unen específicamente a PD-L1. También se divulgan terapias de combinación que comprenden moléculas de anticuerpo anti-PD-L1. Las moléculas de anticuerpo anti-PD-L1 se pueden usar para tratar, prevenir y/o diagnosticar afecciones y trastornos cancerosos o infecciosos.
Patent CR-20190176-A (CR)
Title: Uses of il-13 antagonists for treating atopic dermatitis
Inventor: ZHENG YANAN
IPC: A61K39/02
Filed: 2017-09-22
Abstract: Uses of IL-13 antagonists for treating atopic dermatitis are provided. Also provided are methods of treating atopic dermatitis and methods of reducing the severity of atopic dermatitis by administering IL-13 antagonists.Se proveen usos de antagonistas de IL-13 para el tratamiento de dermatitis atópica. Se proveen también métodos para el tratamiento de dermatitis atópica y métodos para la reducción de la gravedad de la dermatitis atópica mediante la administración de antagonistas de IL-13.
Patent CR-20210429-A (CR)
Title: Anti-transferrin receptor antibodies with tailored affinity
Inventor: GOEPFERT ULRICH
Filed: 2016-06-22
Abstract: Herein is reported an anti-transferrin receptor antibody that specifically binds to human transferrin receptor and cynomolgus transferrin receptor, which comprises i) a humanized heavy chain variable domain derived from the heavy chain variable domain of SEQ ID NO: 01, and ii) a humanized light chain variable domain derived from the light chain variable domain of SEQ ID NO: 26, wherein the antibody has an off-rate for the human transferrin receptor that is equal to or less than (i.e. at most) the off-rate of the anti-transferrin receptor antibody 128.1 for the cynomolgus transferrin receptor, whereby the off-rates are determined by surface plasmon resonance, and whereby the anti-transferrin receptor antibody 128.1 has a heavy chain variable domain of SEQ ID NO: 64 and a light chain variable domain of SEQ ID NO: 65.
Patent CR-20220426-A (CR)
Title: A continuous flow process for preparation of acephate and its intermediates
Inventor: KINI PRASHANT VASANT
IPC: C07F9/02
Filed: 2021-01-25
Abstract: The present invention relates to a continuous flow process for synthesis of acephate and its intermediates. The present invention more particularly relates to synthesis of acephate and its intermediates in a microreactor system.
Patent EC-SP066827-A (EC)
Title: Sales de o-desmetilvenlafaxina en multiparticulas y usos de las mismas
Inventor: SHAH SYED MUZAFAR
IPC: A61K31/137
Filed: 2006-09-06
Abstract: Se describe un succinato o formiato de O-desmetilvenlafaxina en multipartículas (ODV); también se describen métodos para tratar depresión y reducir los efectos secundarios gastrointestinales de ODV
Patent EC-SP088397-A (EC)
Title: Derivados de amida heterociclica útiles como microbiocidas
Inventor: EHRENFREUND JOSEF
IPC: C07D231/14
Filed: 2008-04-23
Abstract: La invención se relaciona con un compuesto fungicidamente activo de la fórmula (I): ,donde Het es un anillo heterocíclico de 5 o 6 miembros, que contiene uno a tres heteroátomos, donde cada uno se selecciona de manera independiente de oxígeno, nitrógeno y azufre, donde el anillo está sustituido con los grupos R6, R7 y R8; R1 es hidrógeno, alquilo C1?4, haloalquilo C1?4, alcoxi C1?4, haloalcoxi C1?4, CH2C=CR9, CH2CR10=CHR11, CH=C=CH2 o COR12; R2 y R3 son, de manera independiente, hidrógeno, halo, alquilo C1?4, alcoxi C1?4, haloalquilo C1?4 o haloalcoxi C1?4; R4 y R5 se seleccionan de manera independiente de halo, ciano y nitro; o uno de R4 y R5 es hidrógeno, y el otro se selecciona de halo, ciano y nitro; R6, R7 y R8 son, de manera independiente, hidrógeno, halo, ciano, nitro, alquilo C1?4, haloalquilo C1?4, alcoxi C1?4-alquilo C1-4, haloalcoxi C1?4-alquilo C1-4 o haloalcoxi C1?4, siempre que por lo menos uno de R6, R7 y R8 no sea hidrógeno; R9, R10 y R11 son, de manera independiente, hidrógeno, halo, alquilo C1?4, haloalquilo C1?4 o alcoxi C1?4-alquilo C1?4; y R12 es hidrógeno, alquilo C1?6, haloalquilo C1?6, alcoxi C1?4-alquilo C1?4, alquiltio C1?4-alquilo C1?4, alcoxi C1?4 o arilo; con la preparación de estos compuestos; con nuevos intermediarios utilizados en la preparación de estos compuestos; con composiciones agroquímicas que comprenden por lo menos uno de los nuevos compuestos como ingrediente activo; con la preparación de las composiciones mencionadas; y con el uso de los ingredientes activos o de las composiciones en agricultura u horticultura, para el control o la prevención de la infestación de plantas por microorganismos fitopatógenos, preferentemente, hongos.
Patent FI-20000141-A (FI)
Inventor: DOBRIN BOGDAN-PAUL
IPC: H04N19/895
Filed: 2000-01-24
Abstract: The invention relates to a method for reducing visual artefacts in a digital image, which is coded by blocks (B 1 , B 2 , B 3 , B 4 ) and then decoded. In the method filtering is performed to reduce visual artefacts due to a boundary (R 12 , R 13 , R 24 , R 34 ) between a current block and an adjacent block (B 1 , B 2 , B 3 , B 4 ). The filtering is performed after the current block (B 1 , B 2 , B 3 , B 4 ) is decoded and there is a boundary available for filtering between the current block and a previously decoded block.
Patent FI-20075971-A (FI)
Inventor: TALLBERG THOMAS
IPC: A61K35/30
Filed: 2007-12-28
Abstract: Biological medical means for treating sterile inflammatory diseases are disclosed. The invention relates to the use of L-arginine-hydrochloride (Arg) or lysine (Lys) and L-leucine (Leu) for the manufacture of a pharmaceutical composition for treating or preventing sterile inflammation. The composition further comprises trace elements chromium (Cr), tin (Sn), selenium (Se), strontium (Sr), vanadium (V), wolfram (W) and folic acid. The pharmaceutical composition can further comprise zinc (Zn) and or manganese (Mn) as well as central nervous system (CNS) lipids. Sterile inflammations are related to disorder such as fibromyalgia, Crohn's disease, psoriasis and rheuma.
Patent FI-20175481-A (FI)
Title: Cable feedthrough element and frame
Inventor: AURASTO ORKO
IPC: H02G3/22
Filed: 2017-05-29
Abstract: The invention relates to a feedthrough element for passing cables in a sealed fashion through a partition. The feedthrough element comprises a first body consisting of compressible material and comprising a first interface and a second body consisting of compressible material and comprising a second interface. The first interface and the second interface are adapted to be pressed against each other to form one or more annular holes for passing a cable through the feedthrough element. The feedthrough element also comprises a plurality of flexible annular collars for providing a plurality of sealing contacts with the cable, the collars being located within each of the one or more holes. The invention additionally relates to one or more feedthrough elements in a frame.
Patent GB-1021299-A (GB)
Abstract: 1,021,299. Gear pumps. INSTRUMENT METRON A.B. June 10, 1964 [June 11, 1963], No. 23975/64. Heading F1F. A gear pump of the internally-meshing type comprises a pressure-regulating valve-assembly on one side of a body 1 (Fig. 1, not shown) adjacent an outlet passage 6 for pumping gears 4, 5 which are situated on the other side of said body, a pre-determined pressure at which said assembly opens being dependent on the rate of flow of liquid through a shallow groove 3 from passage 6 to a re-circulating passage 8 located in register with a driving shaft 7 and communicating with a suction, or supply, conduit 9. Groove 3 has a non-uniform crosssectional area (Figs. 3, 4, 5, not shown) and has its smallest cross-sectional area in a single transverse plane which may be situated adjacent either of passages 6, 8 or therebetween. The valve assembly is preferably of the kind described in Specifications 980,702 and 899,202, and is not shown in the drawings.
Patent GB-1052553-A (GB)
IPC: C01B3/50
Abstract: 1,052,553. Hydrogen by diffusion. IMPERIAL CHEMICAL INDUSTRIES Ltd. April 2, 1965 [April 13, 1964], No. 15197/64. Heading C1A. [Also in Divisions B1 and F2] Hydrogen is separated from cracked ammonia by a diffusion process wherein the purge rate and hence the diffusion rate are automatically controlled in response to the diffusate offtake rate. Cracked ammonia at 400 p.s.i.g. and about 400‹ C. is passed into the diffusion cell, which may have a palladium-silver membrane. Substantially pure hydrogen is removed by the diffusate gas line and a purge gas which may be 85% nitrogen is removed by the purge gas line.
Patent GB-1084053-A (GB)
IPC: F24H3/00
Abstract: 1,084,053. Convector space heaters. C. F. LAWSON. May 8, 1964 [Feb. 27, 1963], No. 7798/63. Heading H5H. A convector space-heater comprises a heating element made up of a thick asbestos base 11 and a thin mica film 13 between which is cemented a resistive ribbon 12, members 11, 13 being further bonded by eyelets 14. The element is mounted by bolts 9 and insulators 10 on brackets 8 inside a casing of trapezium cross-section, one side of which is covered by an expanded metal grille 18 to induce air flow as shown by the arrows in Fig. 2. Base 11 may be of ceramic, mica or a quartz-based material and cover 13 of flexible asbestos sheeting or resin-impregnated fibrous material. The ribbon 12 may be riveted or eyeletted to the base 11. Members 11, 12, 13 form an air-tight bond.
Patent GB-1116931-A (GB)
Abstract: 1,116,931. Shedding mechanisms. R. B. GOLOBART. 4 Oct., 1965 [9 Oct., 1964], No. 41935/65. Heading D1E. Spaced pairs of healds A', B', C' and D' are shed immediately before and immediately after the weft is picked so that they open and close in the sequence A', B', C', D' and are all closed before the intermediate main healds (not shown) close the remainder of the shed. Each pair of healds is operated by one pair only of reciprocating levers 21, 22 one lever operating one heald only. The levers 21, 22 are driven from cams fast on the same shaft 1 and having their lobes 180‹ out of phase so that as one heald is lifted the other is lowered and vice-versa. Blocks 31, 32 carrying the cables 42, 43 are adjustable on toothed portions of the levers 21, 22.
Patent GB-1225174-A (GB)
IPC: B60R17/00
Filed: 1968-04-09
Abstract: 1,225,174. Lubricating; bolt. EATON AXLES Ltd. 9 April, 1968 [19 May, 1967], No. 17105/68. Headings F2A and F2H. A gear 14, Fig. 6, of a vehicle drive mechanism collects lubricant from a reservoir 11a formed in a gear chamber of an axle housing 11 and distributes it through the mechanism, via a filter unit 30, Figs. 1 and 2, which is attached by studs 33, 34 to the housing 11. The filter unit has an annular filter 32 which surrounds the stud 34 and has a cover 60 which is attached by means of screws 61 to a filter box 31. The studs 33, 34 are each provided with an axial passage 120 and 130 and with an interconnecting radial passage 120a or 131. The stud members 33, 34 are threaded into tapped openings 70, 71 respectively in the housing 11 and are locked in position by means of a strap member 72, Fig. 2, and nuts 73, 74 which are threaded on to the respective stud member. Lubricant is removed from the gear 14 by means of a member 21, Fig. 6, and is conveyed through the passages 120, 120a in the stud 33; through the filter 32; through the passages 131, 130 in the stud 34; and to the mechanism.
Patent GB-1226338-A (GB)
IPC: C11D3/48
Filed: 1967-11-07
Abstract: 1,226,338. Bactericidal detergent. COALITE & CHEMICAL PRODUCTS Ltd. 10 Dec., 1968 [7 Nov., 1967], No. 50626/67. Heading A5E. [Also in Division C5] A bactericidal detergent in liquid or powder form comprises dodecylbenzene sulphonate (e.g. sodium or triethanolamine salt) and a talkyl phenol such as p-t-amylphenol. Optional ingredients are other bactericides (e.g. o-benzylp-chlorophenol, o-phenyl-phenol, bis(polychlorophenylol)alkane, 2,2'-dihydroxy-3,5,6,3', 5',6'-hexachlorodiphenylmethane), non-ionic detergents (N-polyethoxylated coconionoethanolamide), builders (sodium sulphate) and humectants (sorbitol). The bactericidal detergent finds application in washing crockery, glasses, floors and butchers' blocks.
Patent GB-1226771-A (GB)
IPC: D01H5/52
Filed: 1968-07-01
Abstract: 1,226,771. Drafting apparatus. MASCHINENFABRIK RIETER A.G. 1 July, 1968 [13 July, 1967], No. 31256/68. Heading DID. A drafting mechanism comprises a rear top-roller saddle 9 mounted in a guide arm 1 with a guide e.g. a slot 10 for the holder 12 of the rear pressure roller and at the front end of the saddle 9 a bearing e.g. a pin 15 for a front saddle 16 having a holder 17 for the front pressure roller and a guide e.g. a slot 19 for the middle pressure roller holder 18, the guide for the holder 18 being in a different plane from that in which the guide for holder 12 is disposed. Thus when the apparatus is, as shown, adjusted for short staple lengths the holder 12 can be positioned beneath the guide 19. Fig. 2, not shown shows the apparatus adjusted for long staple lengths with holder 12 at the rearmost end of slot 10 and holder 18 at the rearmost end of slot. 19. Saddle 9 and arm 1 have a series of aligned holes in which the pin 7 may alternatively be mounted to vary the length of the pivot arm of saddle 9. Saddle 9 also has bores for receiving the pin 15 on which the saddle 16 is pivoted.
Patent GB-1226953-A (GB)
IPC: B67D7/74
Filed: 1967-03-02
Abstract: 1,226,953. Dispensing liquids. VEEDER-ROOT Ltd. 6 May, 1968 [2 March, 1967], No. 9897/67. Heading A4T. Liquid dispensing apparatus comprising a single delivery console containing two pumps connected to different liquid supplies and delivering to a common nozzle, each pump having an associated liquid meter, and means for each pump preset and adapted to cut off delivery after a metered quantity is dispensed, has the two preset means mechanically interlocked to establish a preset ratio of the quantities dispensed. The meters drive shafts 4, 4a with eccentrics 5, 5a oscillate frames 6, 6a carrying pawls 10, 10a for engaging teeth on sector covers 11, 11a and ratchet wheels 2, 2a on shafts 1, 1a. The covers have arms spring-loaded at 21, 21a to abut inversely operating cams 18, 18a adjustable by mixture ratio rack and pinion 16, 17. The ratchet wheels carry pegs 12, 12a by which they can be adjusted against springs 3, 3a via quantity rack and pinion 14, 15. As shown, eccentric 5 rotates twice so that pawl 10 shifts cover 11 by two teeth and then is able to shift ratchet wheel 2 by one tooth for the delivery of three units of one liquid. Eccentric 5a rotates once to shift one tooth on cover 11a and once to shift one tooth on ratchet wheel 2a to deliver two units of the other liquid. Thus five units are delivered in the ratio 3 : 2. Arms 20, 20a on the ratchet wheels, according to adjustment at 14, 15, cut off the pump in turn as they contact trip levers 19, 19a. If a larger quantity in multiples of five units is required, the quantity is set at 14, 15 and the covers spring back to abut the cams 18, 18a and the process is repeated until arms 20, 20a trip levers 19, 19a. Since there are four teeth on each cover and one ratchet wheel tooth may be moved at a time, the preset ratios are 0 : 5, 1 : 4, 2 : 3, 3 : 2, 4 : 1, 5 : 0. The cover may be shifted to trip lever 19, 19a so that no delivery occurs and ratio 0 : 5 or 5 : 0 is obtained.
Patent GB-1227463-A (GB)
IPC: H01M4/13
Filed: 1968-10-01
Abstract: 1,227,463. Altering physical properties; making hollow-ware. DOW CHEMICAL CO. 1 Oct., 1968 [2 Oct., 1967], No. 46595/68. Headings B3A and B3V.  A method for reducing surface cracking upon impact extrusion of extruded magnesium base alloys comprises drawing or rolling in the same direction as it was extruded to reduce the crosssectional area so as to reorientate the surface grains. Thereafter a container, e.g. for a battery anode, may be formed by impact extrusion of the improved metal, preferably after pre-heating it to 400-800‹ F. for 20 seconds to 30 minutes, the impact extrusion die being preheated to 300‹ F. The alloy comprised the following by weight per cent:- the balance being Mg with normal impurities. Drawing or rolling is carried out at 70-500‹ C., with a reduction of 0À5-20%. Reductions of less than about 1% may be followed by annealing at 700‹ F. for 1 hour. The alloy was extruded initially at 600‹ or 800‹ F.
Patent GB-1228709-A (GB)
IPC: A01B3/46
Filed: 1969-05-29
Abstract: 1,228,709. Plough landing device. DEERE & CO. 29 May, 1969 [29 May, 1968], No. 27340/69. Heading A1B. [Also in Division G3] A semi-mounted multi-furrow plough 10 has an automatic landing device 70 to ensure that the plough bodies 42 are accurately positioned adjacent the furrow wall 64. The landing device 70 comprises a depending arm 76 rotatably mounted, about pin 134, on a member 130 which is attached to the link 118 which is in turn pivotally attached to the link 116 by means of the pin 100. The arm 118 is connected to a three-position hydraulic slide valve 72 by means of a spring strap 146. A clock spring 140 biasses the member 130 and the arm 76 in a clockwise sense (as seen in Fig. 1) and a stop 144 is provided to limit any clockwise movement. The arm 116 is pivotally mounted on a securing, bracket by a pin (122), Fig. 2 (not shown), which is substantially parallel to the pin 100. A tension spring 78 biasses the arms 116, 118 towards the furrow wall. The piston rod of a double acting hydraulic jack is attached to the tractor linkage and the plough frame is attached to the jack cylinder. Pressure fluid is supplied to the jack via the three position valve 72. In operation: The plough is caused to be lowered into work by raising the rear wheel 50 and lowering the draught links 12. Should the arm -contact unploughed ground the arm 116 will swing upwardly about its pivot (122), Fig. 2 (not shown), and the arm 76 will swing about pin 134 due to the forward motion of the plough. The angled portion 162 of the arm will then be in contact with the ground and the forward motion will tend to cause the arm 76 to swing outwardly about the pin 100 until the portion 156 drops into the furrow. The pivoting of the arm 76 and 118 about the pin 100 operates the valve 72 through the strap 146 and causes the cylinder 23 to move the plough nearer the furrow until the desired position is reached, i.e. the position in which the valve 72 is held in neutral. The desired spacing is achieved by suitable adjustment of the length of link 82. Any deviation of the plough frame 30 from the desired position is automatically cancelled by the valve 72 and jack 23. The rear wheel 50 is steered by the arm 54 and the crank 56 on the pivot shaft 26.
Patent GB-1230268-A (GB)
IPC: F16J1/09
Filed: 1969-12-06
Abstract: 1,230,268. Cooling pistons. FORD MOTOR CO. Ltd. 6 Dec., 1969, No. 59682/69. Heading F2T. An I.C. engine connecting-rod is forged and has a cylindrical oil chamber drilled in its end, the rim 25 of which is spaced from the underside surface of the piston head so that oil in flowing from the chamber back to the engine sump cools the piston head. The oil is pumped to the chamber through a duct 19 and a groove 13 in a bearing bush 11.
Patent GB-1231854-A (GB)
IPC: C10G45/06
Filed: 1968-04-04
Abstract: 1,231,854. Hydrodesulphurization. GAS COUNCIL. 28 March, 1969 [4 April, 1968], No. 16351/68. Heading C5E. In a process for removing organic sulphur compounds from hydrocarbon liquids the liquids are treated with hydrogen at elevated temperatures and at superatmospheric pressures in the presence of a catalyst composition comprising nickel or cobalt or nickel oxide or cobalt oxide or mixtures thereof together with uranoso-uranic oxide and/or uranium trioxide. The catalyst may be supported on alumina. The feedstock may contain asphaltenes and other highly aromatic structures and also metallo-organic compounds.
Patent GB-1232286-A (GB)
IPC: H01L21/316
Filed: 1968-06-14
Abstract: 1,232,286. IGFET gate insulation. WESTERN ELECTRIC CO. Inc. 14 June, 1968 [20 June, 1967], No. 28344/68. Heading H1K. An IGFET has a two-part gate insulation, that part nearest the semi-conductor being of silicon dioxide and the other part being of aluminium oxide or of aluminium silicate. The operational mode of otherwise similar IGFETs may be tailored by selecting the thickness of the silica layer, so that both enhancement and depletion mode transistors may be formed in the same integrated circuit by thinning the silica layer of selected transistors during manufacture. All processing steps are given. To deposit aluminium oxide, the chloride and carbon dioxide are diluted in hydrogen and passed over a heated substrate; if silicon tetrachloride is added, aluminium silicate is formed. Electrodes may be of platinum-titanium-platinumgold.
Patent GB-1233939-A (GB)
IPC: C07D295/04
Filed: 1968-09-04
Abstract: 1,233,939. Derivatives of 1 - (3 - phenylpropyl)piperazine. DELALANDE S.A. 7 Aug., 1969 [4 Sept., 1968], No. 41965/68. Heading C2C. The invention comprises compounds of formula wherein R, a chain having up to 6 carbon atoms, is alkoxycarbonylalkyl, cyanoalkyl, alkylcarbonylalkyl or phenyl-substituted hydroxyalkyl in which the phenyl may itself be alkoxysubstituted, and a process for preparing them by reacting a 1 - R - piperazine with Ph(CH 2 ) 3 Br. Therapeutic compositions for oral, parenteral or rectal administration comprise compounds of the above formula, which are hypotensive, vasodilatory, adrenolytic, spasmolytic and diuretic.
Patent GB-1251502-A (GB)
IPC: C07C17/361
Filed: 1968-10-14
Abstract: 1,251,502. Chlorination. FARBWERKE HOECHST A.G. 14 Oct., 1968 [13 Oct., 1967; 23 Dec., 1967; 22 June, 1968; 15 July, 1968; 7 Aug., 1968], No. 48554/68. Heading C2C. CCl 4  is produced by reacting benzene and/or one or more chlorinated aromatic hydrocarbons, optionally together with one or more chlorinated aliphatic hydrocarbons, with an amount of chlorine ranging from the stoichiometric amount up to a 200% excess, the reaction components being passed in a first stage through a prereaction zone maintained at temperatures from the melting point of the starting material to 400‹ C., and then being reacted in a second stage in the gaseous phase at temperatures of 400‹ -  800‹ C. in a reactor which is corrosion-resistant under the reaction conditions, the pressures in both reactors being substantially equal and within the range of 20-200 atmospheres gauge. By-products, e.g. hexachlorobenzene, hexachloroethane, trichloroethylene and tetrachloroethylene, may be recycled. The starting material may be a mixture of mono-, di- and tri-chlorobenzenes obtained by catalytic oxychlorination of benzene using the HCl by-product of the process of the invention.