Patent SG-11201902940R-A (SG)
Title: Bacterial minicells for delivering nucleic acid adjuvants and methods of using the same
Inventor: BRAHMBHATT HIMANSHU
IPC: A61K48/00
Filed: 2017-10-04
Abstract: PPVOUNV. dsRNA PPP WIM.14 4+9%1AV ( RIG-1) (MDAS) DNA € 1, 0 4 13K ( AIM2 ) cGAMI) ( ASC ) ( TBK ) C casPa- Pro-inflammatory cytokines Mitochondrion Cytosol Endosome IL-0 & IL-18 DNA 'D)00,4 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 April 2018 (12.04.2018) WIP0 1 PCT omit VIII °nolo olliolu VIII oloiliono oimIE (10) International Publication Number WO 2018/065923 Al (51) International Patent Classification: A61K 48/00 (2006.01) A61K 47/46 (2006.01) (21) International Application Number: PCT/IB2017/056131 (22) International Filing Date: 04 October 2017 (04.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/405,074 06 October 2016 (06.10.2016) US (71) Applicant: ENGENEIC MOLECULAR DELIVERY PTY LTD [AU/AU]; Building 2, 25 Sirius Road, Lane Cove West, Sydney, New South Wales 2066 (AU). (72) Inventors: BRAHMBHATT, Himanshu; c/o Engeneic Molecular Delivery PTY LTD, Building 2, 25 Sirius Road, Lane Cove West, Sydney, New South Wales 2066 (AU). MACDIARMID, Jennifer; c/o Engeneic Molecular Deliv- ery PTY LTD, Building 2, 25 Sirius Road, Lane Cove West, Sydney, New South Wales 2066 (AU). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: BACTERIAL MINICELLS FOR DELIVERING NUCLEIC ACID ADJUVANTS AND METHODS OF USING THE SAME Figure 1 Endosomal receptors Cytosolic receptors (57) : This disclosure provides intact bacterially derived minicells containing nucleic acids adjuvants or plasmids encoding O nucleic acids adjuvants that can produce a desired immune response in target cells. This discosure further provides methods that employ \" minicells to deliver nucleic acids adjuvants for use in the treatment of diseases, including neoplastic disease and cancer. C [Continued on next page] WO 2018/065923 Al MIDEDIM011010EIRDERI0 1111111111111111111111111111111111111111 Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3))