Patent SG-11201908247R-A (SG)
Title: T cell receptor like antibodies that bind to p53-mhc class i complex
Inventor: WANG CHENG-I
IPC: A61K39/395
Filed: 2018-03-01
Abstract: 11 , 10OP9EN90AP6OI : Nn60 9FILPO1APKILKININELE50NP NRFSGSKSOTSASLAITOLCNEDEADNICOODSNISAWVFOGOTICTILSOPKAAPSVIL FPPESEELPANICATIVCUSOFYPGAVIVAMMISSPVIGOVETUPSKCI.NNYANISVI SLIPEOWK6NI(IVSOOVMEGS1 -vEK - FW,ECS DEO 10140:1) LC-COR1: LC COPS: LC-COM: TOSSSNIGAINE11 (SE0 10 NO:I 7, NINRPS (6E0 ID NW.) PSVOSKLSAWY (3E010 NO:1s) PIC1 PICI em• IL, 1E11 OSVITOPPSVSGAPGOR,ISO, _,,MBIUMMWYCOLMITAP<LLIVONTNRPSOVP O RFRARNSGI - SAS, riSLCMEDENIVVCORIMSNISAMMSPOlLTILSOPKAN.SVIL FPPSSEELSANHATIVGLISOF,O.TJAWOOSSMIGOVETTIMI(CSMIMASSYL SLTPECIWKSX.VSCOWTHEGSTVEKTVAPAEGS (SE0 DN.) (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 13 September 2018 (13.09.2018) WIP0 I PCT omit IIl °nolo ow (10) International Publication Number WO 2018/164637 Al (51) International Patent Classification: C07K 16/32 (2006.01) G01N 33/53 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/SG2018/050093 (22) International Filing Date: 01 March 2018 (01.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201701883R 08 March 2017 (08.03.2017) SG (71) Applicant: AGENCY FOR SCIENCE, TECHNOLO- GY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10, Connexis North Tower, Singapore 138632 (SG). (72) Inventors: WANG, Cheng-I; c/o Singapore Immunology Network, 8A Biomedical Grove, Singapore 138648 (SG). LOW, Lionel; c/o Singapore Immunology Network, 8A Biomedical Grove, Singapore 138648 (SG). GOH, Ange- line; c/o Singapore Immunology Network, 8A Biomedical Grove, Singapore 138648 (SG). WANG, Bei; c/o Singapore Immunology Network, 8A Biomedical Grove, Singapore 138648 (SG). LEE, Wen-Hsin; c/o Singapore Immunology Network, 8A Biomedical Grove, Singapore 138648 (SG). HUANG, Ching-Wen; c/o Singapore Immunology Net- work, 8A Biomedical Grove, Singapore 138648 (SG). (74) Agent: SPRUSON & FERGUSON (ASIA) PTE LTD; P.O. Box 1531, Robinson Road Post Office, Singapore 903031 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = (54) Title: T CELL RECEPTOR LIKE ANTIBODIES THAT BIND TO P53-MHC CLASS I COMPLEX (57) : Antibodies and fragments thereof which bind to peptide-MHC complexes are described. In particular, an antibody binding to a peptide-MHC complex comprising a peptide of p53 and a MHC Class I molecule comprising a-chain encoded by an HLA-A*24 allele is claimed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods of treating, preventing and diagnosing cancers using the same. c-crm MSSSNIEMOYFTN (SFO LC-C131:12: ONINRPS (SEP NCtI LC-CORM OSYLISKL,..1 (SEP 10 NO:I s) 10, PIC1 trn OSYLTOPPSVEAAPOPRVUSCAARYANICMDHONTOOLPER,10-LN2IIIIIMOVP LIRFSGSKSPI SASNI IGIC1,136.NlINCOSYPSNISAWY.601 NI I ILSOPINAFSV I L FPPSSEELOANIGTLYDUSOPIPGAVN,f4.13SSPVKAPVETTI7SKOSMICIAPSSYL 31.173.1.111.50,,HEGSTVEKTVAP.ECS ISE° DN.) LC-CORI: MISTSNIOLISVE111 (SRI 0 NO:20) LC CURS: GNINIVS(ShO IU X01 61 LC COPS: OSNOSKISAWY (00310 NO:IS) SEGMS • OGSPGrII ILSTII S G S S P L E E . K(FLAOS/V CJI W ASOSIGTPAMOOK,NPEP IPL LIYM ASV B F E IPG.IS)ERO SGTOO L INNMV ED KVONAL 00 BV 0 00 NRV TISISS F T-131. L100,SW.IHPGLSS,IO1.1-NliLC,SONKNI)OS II D YLDKVVID e SLO IP F LC-CORI: RASOSIOTO(A 0E0 ID NOM) LC-COM: OASNRAT (SEP ID NO2.) LC-COM: PCRSNWP, (SEC D NOM) ON,TOPSSVSGAPPORVTISC,RMNIANGTOVUWYCOLPETA.KILIT210013MGY PORM01.03010ASUrOLOAE0640 00011(LP/LOOPKAAPS VII.F.PSSEELCANKKILYCLIOMPOPVTVAVIKADBSMOVEHWOENNIGIAS EIVIALTPEOWIMINSYSCQVTHEGSNEN - VAPTECS (SEP D NO., W O 20 18/ 16 4637 Al LC-CDRI: MeSSNIPAGYLIVH (8E010 N021) LC-COM: PHINFIPS MEP 10 NO:251 LC CO: R OSYDENISITIVIV (SE0 10 NO:03) ELSA n OSVLIOPPSVSGAPOOMTIS HWYCOLPSTA.KILIIMINIMOV YOMSOEINSO I SWAN I PLOMDMITIVOOSIDSSISAW , O.0301KUVLOOPIUMPSV .Y.SebbLOININI LYCLISPFTYPt, ,,,KALXISYVING. I I liPSKOGNNIMASS BLIPEOWKSHICSYSCPVTHEGSTVEKTVAPAEM (SEP 1D NO:81 LGCORI: TOMSNIGAMOVN (SEP IP NOV LC-CORI: GINNRPS (6E0 10 NO:25) LC-COM: MYCOSIS/MY (8E310 W.) CBAJOIMSVSOSLOGSMS OCI.K.V101.11YDVSRPcEN RORMORKSONIMI MNI PAMFAO'ffriTIT.Mill VFGPII. IQ FFMISEELOANKATIVC-180FIPOINTV,KADOSPVKAENETTPSKOMICMSTIL SITPEOWKSI.FISYSAJTHEGSNEKNAPAEGS (SEP ID NO 7) LC-CORI: MTSSOVOITINTVS (SEP ID W:213) LC-CORI: OVSSRM :5E010 NOSS) LC-COM: SWITYM0, (SEP IP NO:31) [Continued on next page] WO 2018/164637 Al MIDEDIMOMOIDEIREEMOMOHINIEHINIENVOIMIE TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE