baber/WOPTO huggingface dataset:
Patent NZ-585395-A (NZ)
Title: Pyridazinone derivatives as parp inhibitors
Inventor: BRANCA DANILA
IPC: A61K31/501
Filed: 2008-11-14
Abstract: The disclosure relates to pyridazinone derivative compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal-damage, skin senescence and UV-induced skin damage, and as chemo-or radiosensitizers for cancer treatment; and are also useful for reducing cell necrosis (in stroke and myocardial infarction), down regulating inflammation and tissue injury, treating retroviral infections and protecting against the toxicity of chemotherapy.
Patent NZ-588649-A (NZ)
Title: Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands
Inventor: COOK JAMES H II
IPC: C07D498/20
Filed: 2009-04-20
Abstract: Disclosed are oxazole substituted 4-azabicyclo[2.2.2]octane compounds of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of formula (I) are: (R)-N-(6-(3-Methoxyphenyl)pyrimidin-4-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine; (R)-2-(4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octane]-2-ylamino)thiazolo[5,4-b]pyridin-5(4H)-one and (R)-N-(5-Bromo-4-(pyridin-3-yl)pyrimidin-2-yl)-4H-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octan]-2-amine. Also disclosed is a pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament for the treatment of schizophrenia or Alzheimer's Disease.
Patent NZ-589170-A (NZ)
Title: Stereoscopic editing for video production, post-production and display adaptation
Inventor: SMOLIC ALJOSA ALEKSEJ ANDREJ
IPC: H04N13/122
Filed: 2010-11-10
Abstract: A system and computer implemented method for stereoscopic modification of a video frame is disclosed. The system comprises one or more computer processors and a memory containing a program which, when executed by the one or more computer processors, is configured to perform an operation. The operation comprises: providing at least one video frame, where each video frame comprises at least two stereo images; and stereoscopically modifying a video frame by: determining at least one visual characteristic of the video frame and a set of disparities of the video frame; computing at least one mapping function based on: (i) at least one predefined aspect of disparity of the video frame that is desired to be altered, and (ii) the determined visual characteristic and the set of disparities; and altering at least one stereo image of the video frame using the computed at least one mapping function.
Patent NZ-589419-A (NZ)
Title: Compositions comprising an ultraviolet radiation-absorbing polymer
Inventor: COLE CURTIS
Filed: 2009-06-29
Abstract: Disclosed is a UV-absorbing polymer, said UV-absorbing polymer comprising the polymerization reaction product of: a first ethylenically unsaturated monomer comprising a first pendant group that comprises a UV -absorbing moiety, and a second pendant group selected from the group consisting of H, or C1 to C12 alkyl; and a second ethylenically unsaturated monomer selected from the group consisting of monomethacryloxypropyl polydimethylsiloxane and methacryloxypropyl trimethoxysilane, wherein the number of repeat units of said first reacted monomer per molecule is from about 1 to about 6000 and the number of repeating units of said second reacted monomer per molecule is from about 2 to about 6300, said UV-absorbing polymer having a weight average molecular weight of at least 2000 and comprising at least 5 mole per cent of said first pendant group. Also disclosed is the UV absorbing polymer in a blend including a second UV absorbing polymer wherein the blend is capable of providing both synergistic SPF and PFA protection over a mass per cent range of the first and second UV absorbing polymers of at least 40 per cent. Also disclosed is a method of protecting mammalian skin or hair from UV radiation comprising topically applying the composition to skin or hair as a sunscreen or sunblock.
Patent NZ-598012-A (NZ)
Title: Processes for the preparation of 1,2,4-oxadiazole benzoic acids
Inventor: ALMSTEAD NEIL G
IPC: C07D271/06
Filed: 2007-09-06
Abstract: 598012 Disclosed is a process for preparing a compound of formula (I): comprising performing the following steps without isolation of an intermediate: (1) reacting the cyanobenzoic acid methyl ester of formula (II) with hydroxylamine, to give formula (II) followed by (2) acylation with 2-fluorobenzoyl chloride, to give formula (IV) followed by (3) condensation to give formula (I).
Patent NZ-599440-A (NZ)
Title: Method of scale inhibition
IPC: C02F5/12
Filed: 2007-05-25
Abstract: IP No. 599440 A method is disclosed to inhibit scale formation in during oil recovery, whereby a threshold amount of a scale inhibiting agent, represented by an aminoacid alkylphosphonic acid, is added to the aqueous system. The aminoacid moiety can be represented by ?-species or by species having, at least, two or more carbon atoms between the carboxylic moiety and the amine group. These aminoacid based inhibitors exhibit unusually superior performance and system acceptability compared to leading state-of-the-art inhibitors.
Patent NZ-599852-A (NZ)
Title: Trench Drainage System
Inventor: MCGOVERN BRIAN
IPC: E01F5/00
Filed: 2012-05-08
Abstract: A trench drainage system (60) has parallel L-shape support rails (61) toed in towards each other and located into a dug trench by supports. A trough (62) is suspended below the rails. A grate (63) is supported over the rails and held by clips (65) that pass over the grate and under the rail lips.
Patent NZ-613566-A (NZ)
Title: Methods and device to reduce slosh energy absorption effects by reducing blood flow from the cranium
Inventor: SMITH DAVID
IPC: B64D10/00
Filed: 2011-10-11
Abstract: Disclosed is a device to reduce slosh energy absorption in an animal or human subject. Slosh is the differential acceleration between the skull and its contents when acceleration is applied to the skull resulting in brain fluids colliding with themselves resulting in traumatic brain injury. At present, helmets are effective in preventing penetration or fracture of the skull, but a helmet has little ability to mitigate slosh effects. The device comprises a collar which is configured to partially encircle the neck of an animal or human subject. At least one region of the collar is inwardly directed to contact the neck. The at least one region contacting the neck applies a localised pressure to a neck vein restricting blood flow by compression thus increasing intracranial blood volume to reduce slosh by bracing the brain.
Patent NZ-619433-A (NZ)
Title: Methods, apparatuses, and systems for speed control of a movable partition
Inventor: HALL DUANE O
IPC: H02P6/14
Filed: 2012-05-17
Abstract: Disclosed is a motor control system for motivating a movable partition (290). The system includes a motor (240) for mechanical coupling to the movable partition (290), a switching circuit (230) operably coupled to the motor (240) for selectively coupling the motor (240) to a positive power source and a negative power source responsive to one or more PWM signals. An encoder (250) generates one or more rotation signals indicative of operational direction and operational speed of the motor (240) and a motor controller operably coupled to the switching circuit and the encoder and improves airflow around panels of the movable partition (290) when a lead post of the movable partition (290) is between a predefined position and a fully retracted position indicative of a billowing effect for the panels. This is done by adjusting pulse widths of the one or more PWM signals to control a rotational speed of the motor (240).
Patent NZ-627064-A (NZ)
Title: Garment and brassiere accessory
Inventor: DE SOUSA JOSE DE JESUS
IPC: A44C25/00
Filed: 2011-05-11
Abstract: A brassiere accessory garment consisting of a body (3) of textile with attachment straps (8) to attach to a brassiere (13). The straps extend from the top of the body, loop around the brassiere shoulder straps (14) and couple back to the body end of the strap via a fastener (9). A further strap is located at the bottom of the body to loop around the centre of the brassiere in a similar manner. The garment is designed to cover the chest to allow the use of low cut tops in a formal or modest environment. The garment comprises attachment means for jewellery (21), which may comprise loops, hooks, or clasps. An extension strap for extending the length of an attachment strap is included.
Patent NZ-629197-A (NZ)
Title: Methods and composition for enhanced forage quality
Inventor: WHALEN DAVID
IPC: C12N15/82
Filed: 2013-06-26
Abstract: Disclosed is a method to select an alfalfa plant with enhanced feed value components from a population of alfalfa plants, wherein said population of alfalfa plants comprises a recombinant DNA molecule and wherein said recombinant DNA molecule has at least about 90% sequence identity with SEQ ID NO:1 or SEQ ID NO:2, comprising: (a) measuring the concentration of acid detergent lignin (ADL), guaiacyl lignin (G-lignin), and neutral detergent fibre digestibility (NDFD) in a lower stem tissue from each of said alfalfa plants in said population of alfalfa plants; (b) selecting an alfalfa plant that comprises the following enhanced feed value components: (i) a concentration of ADL reduced between 12% and about 31% compared to a lower stem tissue of a control alfalfa plant not comprising said DNA molecule; (ii) a concentration of G lignin reduced by about 25% or greater in said lower stem tissue compared to a lower stem tissue of a control alfalfa plant not comprising said DNA molecule; and (iii) a NDFD value increased by greater than 18% in said lower stem tissue compared to a lower stem tissue of a control alfalfa plant not comprising said DNA molecule; and (c) growing the alfalfa plant selected in step (b).
Patent NZ-707366-A (NZ)
Title: Novel histone deacetylase inhibitors and their use in therapy
Inventor: SHUTTLEWORTH STEPHEN JOSEPH
IPC: A61K31/4439
Filed: 2013-11-06
Abstract: A compound of the formula:(I) or a pharmaceutically acceptable salt thereof, wherein: L is a 5-membered nitrogen-containing heteroaryl which is optionally fused to a benzene; Y is a 5, 6 or 7-membered nitrogen-containing heteroaryl, which is optionally fused to a benzene; and W is a zinc-binding group. The compounds are HDAC inhibitors and therefore have potential utility in therapy.
Patent NZ-707832-A (NZ)
Title: 2-pyridone compound
Inventor: KURODA SHOICHI
IPC: A61K31/4439
Filed: 2013-11-12
Abstract: The present invention is directed to a 2-pyridone compound represented by formula [1] or a tautomer of said compound, or a pharmaceutically acceptable salt of said compound or said tautomer, or a solvate of said compound or the like and is useful as a pharmaceutical for treating disorders such as diabetes as it has superior glucokinase activating effects.
Patent NZ-711668-A (NZ)
Title: An inhaler comprising a tiotropium-containing-composition
Inventor: ZENG XIAN-MING
IPC: A61P11/00
Filed: 2012-12-12
Abstract: A pressurised metered dose inhaler or asthma puffer comprising a canister, wherein the canister contains a formulation comprising a tiotropium salt, and organic acid and an HFA propellant is described. The inhaler has a resilient spring button (460) for applying a preload capable of actuating the internal valve of the canister (40) to release a metered dose of the formulation from the canister. It also includes a resisting mechanism (440. 495, 540) for stopping unwanted discharge of a dose.
Patent NZ-713493-A (NZ)
Title: Flash freezing for campylobacter reduction
Inventor: HALL JEREMY
IPC: A23B4/09
Filed: 2012-06-07
Abstract: Disclosed is a process of reducing the number of viable microorganisms present on the surface of meat, comprising the steps of: a) providing an untreated meat item having a surface membrane and muscle tissue, said untreated meat item having viable microorganisms on the surface membrane, and an atmosphere surrounding the meat item; b) cooling the meat item by reducing the temperature of the atmosphere surrounding the meat item at a rate of between 0.5 °C/s and 5 °C/s, until the surface membrane reaches a first temperature as measured by a probe inserted within or just below the membrane of between -5 °C and 2 °C; c) allowing the surface membrane to warm to a second temperature higher than the first temperature to give a treated meat item; wherein the number of viable microorganisms present on the surface membrane is reduced, whilst the ß-hydroxyacyl-CoA dehydrogenase (HADH) activity of the muscle tissue is not increased by more than a factor of 2 in the treated meat item compared with the untreated meat item.
Patent NZ-716749-A (NZ)
Title: Multi-axis passenger-carrying aircraft
Inventor: HAO DU
IPC: B64D13/08
Filed: 2016-02-09
Abstract: A multi-axis passenger-carrying aircraft is provided, comprising: an electrical system; a heat exchange system; a cabin; and an accommodating compartment arranged inside the cabin; wherein the electrical system is arranged inside the accommodating compartment, and wherein the heat exchange system comprises at least an air inlet communicated with the exterior of the cabin, an air outlet communicated with the accommodating compartment, and a cooler with an air inlet end communicated with the air inlet and an air outlet end communicated with the air outlet. In operation, air outside the aircraft may enter the heat exchange system via the air inlet and the cooler via the air inlet end to be cooled by the cooler. The cooled air may be discharged via the air outlet end and then enter the accommodating compartment via the air outlet, providing cool air to the accommodating compartment and dissipating heat from the electrical system. In this way, it allows more stable operation of the electrical system and higher safety factor of the aircraft to ensure its safety.
Patent NZ-732015-A (NZ)
Title: Anti-egfr antibody drug conjugate formulations
Inventor: VINEET KUMAR
IPC: A61K39/395
Filed: 2014-03-14
Abstract: Discloses anti-EGFR antibody-auristating drug conjugate formulations comprising an IgG antibody. The antibody has the HCDR sequences of SEQ ID NO: 15-17 and the LCDRs of SEQ ID NO: 20-22 or the HCVR of SEQ ID NO: 13 and the LCVR of SEQ ID NO: 18. The auristatin can be monomethylauristatin F (MMAF). The formulation further comprises a sugar, buffer and a surfactant, wherein the buffer is selected from the group consisting of acetate, succinate, gluconate, methionine, imidazole, histidine, glycine, arginine, citrate, phosphate, and citrate and phosphate
Patent NZ-734670-A (NZ)
Title: Cells for producing recombinant iduronate-2-sulfatase
Inventor: BOLDOG FERENC
IPC: C12P21/06
Filed: 2013-06-28
Abstract: The present invention provides methods and compositions for production of recombinant iduronate-2-sulfatase (I2S). The invention encompasses the discovery that more potent recombinant I2S protein can be produced by cells engineered to co-express a recombinant I2S protein and a formylglycine generating enzyme (FGE). According to the invention, a cell in cell culture conditions produces I2S protein comprising at least about 70% conversion of the cysteine residue corresponding to Cys59 to Cα-formylglycine (FGly), and at a specific productivity rate of greater than about 30 picogram/cell/day and/or at a level of I2S between 0.3-fold and 10-fold higher than the level of formylglycine generating enzyme. Such cells are adaptable to various cell culture conditions, and in some embodiments are adaptable to a large-scale suspension serum-free culture. Recombinant I2S produced in accordance with the present invention can be used in enzyme replacement therapy, for example in treating Hunter syndrome.
Patent NZ-734998-A (NZ)
Title: Pyolysin methods and compositions
Inventor: MOONEN GLENN
IPC: C07K14/195
Filed: 2016-03-14
Abstract: Methods for improved cultivation media and culture conditions for Trueperella pyogenes are disclosed herein. Also disclosed are improved methods for the isolation and purification of pyolysin from T. pyogenes as a potential candidate for compositions useful in reducing or preventing bovine metritis.
Patent NZ-742177-A (NZ)
Title: A thermostatic mixing valve with disinfecting facility
Inventor: FORRESTAL DAVID PETER
IPC: F16K11/07
Filed: 2016-11-04
Abstract: A thermostatic mixing valve including: a body comprising: a first fluid inlet; a second fluid inlet; an outlet; and a thermostatic element connected to a return spring and a piston; an intermediary body connected to the body, the intermediary body configured to support a housing containing an overtravel spring, the overtravel spring configured to resist a force applied by the thermostatic element during movement thereof; and a plunger extending into the housing, the plunger interacts at its end with the overtravel spring, wherein: in a normal operational condition, movement of the thermostatic element assists with moving the piston such that movement of the piston controls fluid flow from the first fluid inlet and the second fluid inlet to the outlet in order to achieve a relatively constant temperature output; and rotating the plunger: provides a thermal disinfection condition whereby the plunger adjusts the resistance applied onto the thermostatic element from the overtravel spring, thereby allowing the return spring to overcome the overtravel spring, despite the thermostatic element being subjected to a higher temperature, or allow the thermostatic element to extend without engaging the plunger, such that hot water having a temperature higher than the relatively constant temperature output flows through the thermostatic mixing valve to thermally disinfect the valve; and allows the valve to return to the normal operational condition after the thermal disinfection condition.
Patent NZ-750789-A (NZ)
Title: Imidazopyrazine syk inhibitors for the treatment of cancers and other hyperproliferative disorders
Inventor: ABELLA ESTEBAN M
IPC: A61P29/00
Filed: 2017-09-14
Abstract: The application provides methods of treating or reducing aplastic anemia in a patient in need thereof, comprising the step of administering an effective amount of a compound selected from Compounds 1-6, disclosed herein.
Patent NZ-751264-A (NZ)
Title: Biomarkers and methods of treating pd-1 and pd-l1 related conditions
Inventor: KOEPPEN HARTMUT
IPC: G01N33/574
Filed: 2014-03-12
Abstract: Provided herein are biomarkers for the treatment of pathological conditions, such as cancer, and method of using PD-1/PD-L1 pathway antagonists. In particular, provided are biomarkers for patient selection and prognosis in cancer, wherein the biomarkers are PD-L1 and IFN-g.
Patent NZ-755795-A (NZ)
Title: Rechargeable battery pack
Inventor: FAUTEUX DENIS GASTON
IPC: H01M10/48
Filed: 2017-02-13
Abstract: A rechargeable battery pack attachable to a power tool. The rechargeable battery pack comprising a rechargeable battery; a display comprising an array of segments; a charge sensor for sensing a charge level of the rechargeable battery; a display switch that is user-actuable for inputting a first display command; a current sensor for sensing a current level drawn from the rechargeable battery by the power tool; an abnormality detector for detecting an abnormal condition of the rechargeable battery; and a controller operably connected to the display, the charge sensor, the display switch, the current sensor, and the abnormality detector, for controlling a lighted state of the display to progressively light the segments. In a charge display state, upon receiving the first display command, the controller controls the lighted state of the display to represent a level of charge detected by the charge sensor for a predetermined time. In a current display state different from the charge display state, the controller controls the lighted state of the display to represent a level of current detected by the current sensor. The current display state is a default state active in the absence of an abnormality detected by the abnormality detector and in the absence of the first display command.
Patent NZ-757005-A (NZ)
Title: Treatment for gingivitis
Inventor: REYNOLDS ERIC CHARLES
IPC: A23G4/14
Filed: 2018-03-14
Abstract: The present invention relates to compositions and their use for oral care. In particular, the compositions and methods are for maintaining oral health and/or treating various oral conditions such as gingivitis. The present invention relates to methods and uses of stabilized amorphous calcium phosphate (ACP) and/or stabilized amorphous calcium fluoride phosphate (ACFP) in the preparation of a medicament for reducing pathogenic oral bacteria at an oral site in an individual; increasing commensal oral bacteria at an oral site in an individual; decreasing the proportion of pathogenic oral bacteria at an oral site in an individual; inhibiting oral dysbiosis; reducing gingival inflammation in an individual in need thereof; treating gingivitis in an individual in need thereof; and treating chronic gingivitis in an individual in need thereof.
Patent NZ-759030-A (NZ)
Title: Systems for capturing a client vehicle and related methods
Inventor: SORENSEN PETER O
IPC: B64G1/64
Filed: 2018-02-12
Abstract: A capture assembly utilized for insertion into a nozzle (18) of a liquid engine of a spacecraft (11) to capture it. The capture assembly includes a probe (22) for insertion into the nozzle and an assembly at a forward portion of the probe to capture the spacecraft. The assembly includes a plurality of actuated fingers for deploying outwardly from the probe when the probe is inserted into the nozzle. The method of capture includes the steps of inserting a probe of the capture mechanism having one or more fingers positioned at a distal end of the probe into a cavity of the client vehicle and engaging the client vehicle in the cavity with the one or more fingers with an actuator. Translating one or more quillon assemblies along the probe with the same actuator and toward a necking sidewall of the client vehicle defining the cavity. Engaging the sidewall of the client vehicle with the one or more quillon assemblies to further engage with and secure the client vehicle.
Patent PT-109593-A (PT)
Title: Método e solução de combate a incêndios
Inventor: JOSÉ FRANCISCO MARCOS
IPC: A62C3/02
Filed: 2016-08-22
Abstract: O PRESENTE INVENTO REFERE-SE A UM MÉTODO E SOLUÇÃO DE COMBATE A INCÊNDIOS, INSERIDO NO DOMÍNIO TÉCNICO DO COMBATE A INCÊNDIOS. O MÉTODO É O DA ¿ASFIXIA¿ QUE CONSISTE EM IMPEDIR QUE O OXIGÉNIO CHEGUE À MATÉRIA INFLAMÁVEL OU CHEGUE EM MENOR QUANTIDADE COBRINDO-A POR UMA CAMADA DE LAMA QUE NÃO PERMITA OU REDUZA A COMBUSTÃO E É REALIZÁVEL A PARTIR DE UMA SOLUÇÃO DE ÁGUA E ARGILA EM QUANTIDADES ADEQUADAS AO TIPO DE INCÊNDIO A ATACAR E AO TIPO DE BOMBA A UTILIZAR. A ARGILA É MISTURADA NA ÁGUA IMEDIATAMENTE ANTES DA SUA UTILIZAÇÃO NUM TANQUE OU EM BETONEIRAS E LEVADA EM CISTERNAS PARA O LOCAL DO INCÊNDIO A ATACAR DONDE SERÁ BOMBEADA SOBRE O FOGO OU MISTURADA EM GRANDES BALDES PRÓPRIOS PARA OS HELICÓPTEROS LEVANTAREM E DERRAMAREM SOBRE AS CHAMAS OU SOBRE O ESPAÇO A PROTEGER.