baber/WOPTO huggingface dataset:
Patent ES-2083239-T3 (ES)
Inventor: WIDMER ROBERT
IPC: B23K11/11
Filed: 1993-09-18
Granted: 1996-04-01
Abstract: A multiple electrode resistance spot welding machine for welding wire gratings by means of direct current contains several contact electrodes (4.1.1, 4.2.1, 4.1.2, 4.2.2, ...) which electrically bond a respectively associated grating spot from both sides. The circuit arrangement for the simultaneous application of welding current to all electrically bonded grating spots has a welding transformer for each contact-electrode pair (4.1.1/4.2.1, ..., 4.1.5/4.2.5). According to the invention, welding electrode pairs lying side by side are floating in terms of potential so that the single cross connection is formed by the cross wire (1). A separate contact-electrode pair is provided for each grating spot. <IMAGE>
Patent ES-2088232-T3 (ES)
Title: Colector de segmentos de carbon planar.
Inventor: STROBL GEORG
IPC: H02K13/00
Filed: 1993-07-22
Granted: 1996-08-01
Abstract: UN CONMUTADOR DE SEGMENTOS DE CARBONO PLANO TIENE ELEMENTOS DE CONTACTO 4, CON TERMINALES 31, FIJADOS A LA SUPERFICIE FRONTAL 2 DE UNA BASE AISLANTE 1 MEDIANTE SEGMENTOS DE CARBON SOBREMOLDEADOS 5 FORMADO SOLIDARIAMENTE CON PIEZAS DE ANCLAJE 6 DISPUESTAS DENTRO DE ABERTURA 3 EN EL ELEMENTO DE BASE 1. CADA ABERTURA 3 TIENE UNA SEGUNDA PARTE 8 DISPUESTA HACIA LA PARTE TRASERA DE UNA PRIMERA PARTE 7 QUE TIENE UNA SECCION TRANSVERSAL MAS PEQUEÑA QUE LA SEGUNDA PARTE 8 Y LA PIEZA DE ANCLAJE 6 DISPUESTA DENTRO DE LA ABERTURA 3 TIENE UNA PARTE DE BLOQUEO 10 QUE RELLENA LA SEGUNDA PARTE 8 DE LA ABERTURA 3 PARA DE ESTA MANERA RESISITIR LA RETIRADA DE LA PIEZA DE ANCLAJE 6 DE LA ABERTURA 3. LOS ELEMENTOS DE CONTACTO ESTAN EMPOTRADOS EN LOS SEGMENTOS DE CARBONO 5 Y TIENE AGUJEROS 22 RELLENOS CON MATERIAL DE SEGMENTOS DE CARBONO PARA AUMENTAR EL ENGANCHE ENTRE LOS ELEMENTOS DE CONTACTO 4 Y LOS SEGMENTOS 5.
Patent ES-2093368-T3 (ES)
Title: Bomba de inyeccion de combustible.
Inventor: COOKE PETER MICHAEL
IPC: F02M41/14
Filed: 1993-12-13
Granted: 1996-12-16
Abstract: UN APARATO DE BOMBEO DE COMBUSTIBLE PARA ALIMENTAR COMBUSTIBLE A UN MOTOR DE COMBUSTION INTERNA COMPRENDE UN PRIMER PISTON ACCIONABLE DE PRESION DE FLUIDO (37) MOVIL BAJO LA ACCION DE UN MUELLE (62) PARA AVANZAR LA REGULACION DE DISTRIBUCION DE COMBUSTIBLE POR EL APARATO. EL MUELLE LLEVA EN SU EXTREMO REMOTO DEL PISTON CONTRA UN TOPE DE MUELLE QUE ESTA EN FORMA DE UN PISTON ADEMAS (55). LA POSICION DEL PISTON ADICIONAL SE CONTROLA POR UN DISPOSITIVO DE RESPUESTA DE TEMPERATURA (70) Y CUANDO EL MOTOR ESTA CLIENTE EL PISTON ADICIONAL ES AVANZADO DESDE UNA PRIMERA POSICION A UNA SEGUNDA POSICION. UN PRIMER TOPE (64) LIMITA EL MOVIMIENTO DEL PRIMER PISTON (34) BAJO EL AUMENTO DE PRESION DE FLUIDO CUANDO EL PISTON ADICIONAL ESTA EN SU PRIMERA POSICION Y ESTA ASEGURADO EN EL ALOJAMIENTO Y UN SEGUNDO TOPE (58) LIMITA EL MOVIMIENTO DEL PRIMER PISTON BAJO EL AUMENTO DE LA PRESION DE FLUIDO CUANDO EL PISTON ADICIONA ESTA EN SU SEGUNDA POSICION ESTANDO LLEVADO EL TOPE SOBRE EL PISTON ADICIONAL.
Patent ES-2086903-T3 (ES)
Title: Modulo termorresistivo, dispositivo de calefaccion que lo comprende, y su aplicacion al calentamiento de dispositivos de mando de caudal para instalaciones de alimentacion de motores de combustion interna.
Inventor: JOIGNEAU JEAN-PIERRE
IPC: F02M3/07
Filed: 1993-07-13
Granted: 1996-07-01
Abstract: CONFORME A LA INVENCION, EL MODULO TERMORRESISTIVO, UTILIZABLE COMO DISPOSITIVO DE CALENTAMIENTO ELECTRICO (1'') COMPRENDE UNA TERMISTANCIA DE CTP (20'') ELASTICAMENTE EN TOPE DE DETENCION CONTRA UN CUERPO CONDUCTOR (16''), MEDIANTE UN RESORTE CONDUCTOR (23'') QUE LE CONECTA A UNA BORNA DE ALIMENTACION (25''). LA TERMISTANCIA (20'') ESTA CONECTADA A LA OTRA BORNA DE ALIMENTACION (26'') MEDIANTE EL CUERPO (16''), UNA PLACA DE APOYO (21'') CONDUCTORA Y UN RESORTE (24'') CONDUCTOR, MANTENIENDO LA PLACA (21'') ELASTICAMENTE EN TOPE DE DETENCION CONTRA EL CUERPO (16''). ESTE ULTIMO ESTA ENGATILLADO CON JUEGO SOBRE UN SOPORTE AISLANTE (4'') CON UNA PANTALLA (10'') QUE AISLA LOS DOS RESORTES EL UNO DEL OTRO. UN CONECTOR ELECTRICO (3'') ESTA INTEGRADO EN EL SOPORTE (4''), PROVISTO DE MEDIOS (11'', 12'') DE ESTANQUEIDAD, SOBRE UN ELEMENTO A CALENTAR O DEL CUAL HAY QUE MEDIR LA TEMPERATURA. APLICACION AL RECALENTAMIENTO DE CUERPOS DE CARBURADOR O CUERPO DE MARIPOSA, DE DISPOSITIVOS DE ACCIONAMIENTO DE CONSUMO, DE INSTALACIONES DE ALIMENTACION DE MOTORES DE COMBUSTION INTERNA.
Patent ES-2130238-T3 (ES)
Inventor: EMONDS-ALT XAVIER
IPC: A61K31/397
Filed: 1993-09-28
Granted: 1999-07-01
Abstract: The invention relates to basic quaternary amides of formula <IMAGE>  in which   - Ar represents an optionally substituted mono-, di- or tricyclic heteroaromatic or aromatic group; - T represents a direct bond, a hydroxymethylene group, an alkoxymethylene group in which the alkoxy group is C1-C4 or a C1-C5 alkylene group; - Ar' represents a phenyl which is unsubstituted or substituted one or a number of times, a thienyl, a benzothienyl, a naphthyl or an indolyl; - R represents hydrogen, a C1-C4 alkyl, an  omega -(C1-C4)alkoxy(C2-C4)alkyl or an  omega -(C1-C4)alkanoyloxy(C2-C 4)alkyl,   - Q represents hydrogen; - or else Q and R, together, form a 1,2-ethylene, 1,3-propylene or 1,4-butylene group;   - Am<(+)> represents the radical <IMAGE> in which X1, X2 and X3, together and with the nitrogen atom to which they are bonded, form an azabicyclic or azatricyclic system optionally substituted by a phenyl group;   - A<(-)> is a pharmaceutically acceptable anion.   These compounds are useful in the preparation of medicaments intended for the treatment of pathologies involving the tachykinin system.
Patent ES-2160591-T3 (ES)
Inventor: GORMAN CORNELIA M
IPC: C12N15/16
Filed: 1992-12-04
Granted: 2001-11-16
Abstract: A Chinese hamster ovary (CHO) host cell or a human embryonic kidney (HEK) host cell that comprises a first nucleic acid encoding a prorelaxin polypeptide and a second nucleic acid encoding an enzyme that is capable of cleaving the prorelaxin polypeptide to form a mature, two-chain relaxin polypeptide. <IMAGE>
Patent ES-2080607-T3 (ES)
Inventor: TRANVOIZ RENE
IPC: B62M3/08
Filed: 1992-12-09
Granted: 1996-02-01
Abstract: PCT No. PCT/FR92/01164 Sec. 371 Date Oct. 5, 1993 Sec. 102(e) Date Oct. 5, 1993 PCT Filed Dec. 9, 1992 PCT Pub. No. WO93/11990 PCT Pub. Date Jun. 24, 1993.A device for rapid mounting and removal of a bicycle pedal shaft on a lever or crank arm 4. The pedal assembly comprises a shaft 1 provided with a smooth bearing 5 in the longitudinal direction received in a correspondingly shaped recess at the end of the crank arm or lever, enabling the shaft to be quickly and easily engaged in a removable manner. A retractable retainer 12-14 is provided between the shaft and a threaded ring 2 screwed into the recess in the crank arm or lever.
Patent ES-2108862-T3 (ES)
Inventor: CANFIELD CRAIG
IPC: A61P31/04
Filed: 1993-01-19
Granted: 1998-01-01
Abstract: There are provided compounds of the formula   <IMAGE>   wherein R1 is a substituted or unsubstituted divalent aliphatic group of 1 to 16 carbon atoms; wherein the substituents are mono or poly and are selected from the group consisting of lower alkyl, aryl and arlkyl, R3 is selected from the group consisting of same group of values as R5, R5 is selected from the group consisting of substituted and unsubstituted alkyl of 1-10 carbon atoms, aryl, cycloalkyl and heterocycloalkyl of 3-8 carbon atoms, wherein the substituents are mono or poly and are selected from the group consisting of lower alkyl, cycloalkyl of 3-8 carbon atoms, lower alkenyl, lower alkynyl, nitro, lower alkoxy, lower alkoxycarbonyl, phenyl loweralkyl, phenyl, mono and polyhalophenyl, phenoxy, mono and polyhalophenoxy, R6 and R7 may be the same or different and are hydrogen, alkanoyl or alkoxyalkanoyl, R7 may also have the same value as R5, Y is oxygen or sulfur, m is 0 or 1, q is 0 or 1, wherein the prefix alk designates moieties which are straight chain or branched chain, and the term lower designates 1-6 carbon atoms and the unmodified term alk signifies 1-24 carbon atoms, the respective tautomers thereof, the pharmaceutically acceptable salts and addition salts thereof and the hydrates of said salts and addition salts. There are further provided methods of protecting subjects liable thereto from infections caused by an organism of the group Plasmodium sp., Mycobacterium sp. and Pneumocystis carinii by administering to a subject liable to such infection, a prophylactically effective amount of a compound of the foregoing formula. These compounds will also reduce the level of infection where said subjects have already been infected.
Patent ES-2102016-T3 (ES)
Title: Acoplamiento de conjunto de eje inferior de direccion.
Inventor: CHERPICIAN BERCI
IPC: F16D3/26
Filed: 1993-01-15
Granted: 1997-07-16
Abstract: UN ACOPLAMIENTO DE CONJUNTO DE ARBOL INFERIOR DE DIRECCION (10) PARA ARBOL DE DIRECCION QUE COMPRENDE UN ELEMENTO DE ARBOL INFERIOR (30), UN ELEMENTO DE ARBOL SUPERIOR (31), UN ELEMENTO ELASTOMERICO (20) Y UN PAR DE CONECTORES(32) PARA CONECTAR CON ROTACION EL ELEMENTO DE ARBOL SUPERIOR (31) Y EL ELEMENTO DE ARBOL INFERIOR (30) AL ELEMENTO ELASTOMERICO (20).
Patent ES-2052480-T3 (ES)
Inventor: LAIGLE JEAN
IPC: H02G3/04
Filed: 1993-05-11
Granted: 1997-07-16
Abstract: Cable trough especially for electrical cables. According to the invention, the trough with a generally U-shaped section has, at given longitudinally spaced locations, pairs of holes (24a, 24b) oppositely located in the parallel walls of the block for the temporary insertion of advantageously non-specific retaining elements that facilitate cable laying. The retaining elements are used until the trough is definitively closed using a suitably shaped lid, but can also be left in place.
Patent ES-2100011-T3 (ES)
Inventor: JORGENSEN POVL JORGEN
IPC: B01F7/00
Filed: 1994-10-03
Granted: 1997-06-01
Abstract: The mixer and disperser head (1) comprises a cylindrical, tubular mixing chamber (3) having a plurality of equally angularly spaced discharge slots (7) through its periperal wall, a first plurality of impeller blades (11) rigidly connected to one axial end of the mixing chamber (3), a second plurality of impeller blades (27) rigidly connected to the other axial end of the other end of the mixing chamber (3), and a shaft (15) rigidly connected to the first plurality of impeller blades (11) coaxially with and situated quite outside the mixing chamber. The first (11) and second (27) pluralities of impeller blades being mirror-images of each other relatively off-set by an angle of 60 DEG  about the rotational axis (5) of the mixer and disperser head (1). The first plurality of impeller blades (11) consists of three identical blades (17) angularly off-set by 120 DEG  for each other. Each blade (17) comprising a portion (19) which is leading in the rotational direction (R) of the mixer and dispenser head (1) and a trailing portion (21) forming an inward obtuse angle with the leading portion (19). The leading portion (19) has a first part (23) lying in a plane perpendicular to the axis (5) of rotation and spaced from the one end of the mixing chamber (3) and a second part (24) bent inward about 90 DEG  from the first part (23) and rigidly connected such as by welding (9) to the rim of said one end of the mixing chamber (3). <IMAGE>
Patent ES-2123747-T3 (ES)
Inventor: FODOR ANDREAS DIPL-ING
IPC: E01B7/02
Filed: 1994-11-08
Granted: 1999-01-16
Abstract: Railway switch (points) with rigid rails (2) and pivotable switch blades (switch tongues) (4), at least one roller (1) with a shaft (11) being arranged in the pivoting region, the upper vertex (7) of which lies higher than the corresponding bearing surface (5), the roller (1), in the position of contact of the switch blade (4) on the rigid rail (2), bearing against the switch blade (4) below its upper vertex (7) and, outside this position, the switch blade (4) being able to be carried by rollers (1), and the roller (1) being resiliently mounted in the direction transversely to the track plane (8), the roller (1) being arranged to be adjustable both transversely and in the direction of the track plane (8), and its shaft (11) being oriented in the direction of the rigid rail (2), and the shaft ends (12) of the roller (1) being arranged to be height-adjustable in receptacles (21), and at least one receptacle (21) being holdable indirectly or directly in the direction of the rigid rail (2) via at least one distance piece (29). <IMAGE>
Patent ES-2159299-T3 (ES)
Inventor: MACKRLE SVATOPLUK
IPC: C02F3/30
Filed: 1994-02-07
Granted: 2001-10-01
Abstract: PCT No. PCT/CZ94/00006 Sec. 371 Date Aug. 11, 1995 Sec. 102(e) Date Aug. 11, 1995 PCT Filed Feb. 7, 1994 PCT Pub. No. WO94/18131 PCT Pub. Date Aug. 18, 1994Reactor for biological sewage purification having a tank with a casing and a bottom surface and a funnel-shaped member in the tank. An activation space is defined between the casing and the funnel-shaped member and a separation space is defined inside the funnel-shaped member with a passage in the funnel-shaped member for communication between both spaces. A partition extends from the casing to the funnel-shaped member. A recirculation means defines an inlet communicating with the separation spaces and an outlet communicating with the activation space. A circulation circuit is formed for circulating fluid between the activation space and the separation space.
Patent ES-2162861-T3 (ES)
Title: Procedimiento activado por energia de microondas para la preparacion de material semiconductor de alta calidad.
Inventor: GUHA SUBHENDU
IPC: C23C16/511
Filed: 1994-01-13
Granted: 2002-01-16
Abstract: MATERIAL SEMICONDUCTOR DE ALTA CALIDAD SE DEPOSITA EN UN PROCESO DE ELECTRODEPOSICION DE DESCARGA LUMINESCENTE ENERGIZADO POR MICRONDAS, ENERGIZANDO UN GAS EN PROCESO CON ENERGIA POR MICRONDAS MEDIANTE UN GENERADOR DE MICRONDAS (24) A UN NIVEL DE POTENCIA SUFICIENTE PARA GENERAR UN PLASMA (30) A UN GRADO DE SATURACION DE APROXIMADAMENTE EL 100, E IMPIDIENDO EL ACCESO DE LAS ESPECIES DE ELECTRODEPOSICION A UN SUSTRATO (28) PARA REBAJAR EL INDICE DE ELECTRODEPOSICION A UN VALOR MENOR QUE EL QUE SE CONSEGUIRIA, DE OTRA FORMA, OPERANDO A UN GRADO DE SATURACION DEL 100.
Patent ES-2119183-T3 (ES)
Inventor: MACASKIE LYNNE ELAINE
IPC: C12R1/01
Filed: 1994-03-25
Granted: 1998-10-01
Abstract: PCT No. PCT/GB94/00626 Sec. 371 Date Nov. 13, 1995 Sec. 102(e) Date Nov. 13, 1995 PCT Filed Mar. 25, 1994 PCT Pub. No. WO94/22770 PCT Pub. Date Oct. 13, 1994Removal of a target metal having an insoluble phosphate (e.g. actinides), is effected by passing the solution through a bioreactor containing an immobilised phosphatase-producing microorganism which has been cultivated using a culture medium containing an assimilable organic source of phosphorus and which has been primed with an element, other than the metal to be removed, having an insoluble phosphate so as to deposit the phosphate of the priming element on cell surfaces of the microorganism. The priming element phosphate facilitates deposition of the target metal phosphate.
Patent ES-2114686-T3 (ES)
Inventor: MATTHEWS WENDY ALISON
IPC: C07K19/00
Filed: 1994-05-18
Granted: 1998-06-01
Abstract: Novel generic antibodies are provided that are specific to groups of organophosphates, particularly to a class of organophosphate pesticides in common usage. Further provided are compounds and methods for raising these antibodies, test kits containing them and methods for their use. The antibodies targeted at low molecular weight (i.e. below MW 1000) organophosphorous pesticides methacrifos, pirimphos methyl, etrimfos, fenitrothion, chlopyrifos methyl, dichlorovos and malathion. Preferred conjugates of the invention are of the formula (RO2-P(S)-Z-[Y]-Protein wherein R is lower alkyl and Z is as O, S or -NH-, Y is a spacer group and "Protein" indicates a protein suitable for use in hapten protein conjugates for the purpose of raising antibodies and antisera. Typical and preferred proteins are bovine serum albumin, ovalbumin from chicken egg, keyhole limpet hemocyananin and mixtures of these.
Patent ES-2115948-T3 (ES)
Title: Boquilla de pulverizacion y pulverizador equipado con dicha boquilla.
Inventor: JOUILLAT CLAUDE
IPC: B05B1/30
Filed: 1994-05-25
Granted: 1998-07-01
Abstract: LA INVENCION SE REFIERE A UNA BOQUILLA DE PULVERIZACION DE SUSTANCIA FLUIDA QUE COMPRENDE UN CONDUCTO DE SALIDA 3,4) QUE DESEMBOCA EN UNA CAMARA DE TORBELLINO (5) EN EL CENTRO DE UNA SUPERFICIE ANULAR (10), ESTANDO DICHA CAMARA DE TORBELLINO (5) CERRADA POR UNA PARED DE EXTREMO (5) QUE ESTA PERFORADA CON UN ORIFICIO DE SALIDA (7) Y QUE COMPRENDE UNA CARA INTERNA (A) DOTADA CON RANURAS DE TORBELLINO (8), ESTANDO LA CAMARA DE TORBELLINO (5) PARCIALMENTE RELLENA POR UN NUCLEO 89), DEJANDO EL NUCLEO LIBRE AL MENOS UN PASO LATERAL (11) QUE HACE COMUNICAR LAS RANURAS DE TORBELLINO (8) CON EL CONDUCTO DE SALIDA 3,4), COMPRENDIENDO LA BOQUILLA DE PULVERIZACION ADEMAS UNA VALVULA ADAPTADA PARA OBTURAR EL CONDUCTO DE SALIDA (3,4), CARACTERIZADA EN QUE EL NUCLEO (9) ES UNA PIEZA SENSIBLEMENTE CILINDRICA DE REVOLUCION DE ELASTOMERO QUE ESTA COMPRIMIDA ELASTICAMENTE AXIALMENTE ENTRE LA PARED DE EXTREMO (6) DE LA CAMARA DE TORBELLINO Y DICHA SUPERFICIE ANULAR (10), CONSTITUYENDO EL NUCLEO (9) DICHA VALVULA EN COMBINACION CON LA SUPERFICIE ANULAR, Y ESTANDO APLICADO EL NUCLEO CONTRA LA PARED DE EXTREMO (6) AISLANDO LAS RANURAS DE TORBELLINO (8), DE MANERA QUE LAS RANURAS DE TORBELLINO NO SE COMUNIQUEN ENTRE SI ENTRE EL ORIFICIO DE SALIDA (7) Y DICHO AL MENOS UN PASO LATERAL (119 DEJADO LIBRE POR EL NUCLEO (9).
Patent ES-2138708-T3 (ES)
Inventor: GALEY JEAN-BAPTISTE
IPC: A61K8/00
Filed: 1995-01-20
Granted: 2000-01-16
Abstract: Mono- and di-esters of cinnamic acid (or one of its derivs.) and vitamin C, of formula (I), are new.  R1, R2, R3 = H, OH, alkoxy, fluoroalkoxy or alkylcarbonyloxy; R4 = H or -COR5; R5 = 1-20C alkyl or a gp. of formula (i).
Patent ES-2126867-T3 (ES)
Inventor: ROUANET STEPHANE FABRICE
IPC: A61K8/49
Filed: 1994-11-07
Granted: 1999-04-01
Abstract: A method for providing aerogels, and aerogels produced according to the method is described. The method involves contacting a solution containing material to be processed with a species selected to precipitate the material and selected so as to be miscible with the solvent system of the solution. After the material is precipitated, the material may be washed with the precipitating species until it is substantially free of solvent system. Then the precipitating species containing the material precipitate is taken above its critical point, and the supercritical fluid is exhausted above its critical temperature. Alternately, a separate isolating species is introduced to displace the precipitating species, or the precipitating species/solvent system mixture. The isolating species then is taken above its critical point, and exhausted above its critical temperature. The invention provides for batch or continuous processes. <IMAGE>
Patent ES-2267099-T3 (ES)
Inventor: ZEHAVI EPHRAIM
IPC: H04J13/00
Filed: 1994-10-27
Granted: 2007-03-01
Abstract: An improved system and method for communicating information over in-phase (I) and quadrature phase (Q) communication channels in a spread spectrum communication system is disclosed herein. In an exemplary implementation, first and second information signals are respectively transmitted over the I and Q communication channels using direct sequence spread spectrum communication signals. In-phase pseudorandom noise (PNI) and quadrature phase pseudorandom noise (PNQ) signals of predetermined PN codes are used for spreading the first and second information signals, respectively. In particular, the PNI and PNQ signals are respectively combined with the first and second information signals and an orthogonal function signal to provide I-channel and Q-channel modulation signals. The I-channel and Q-channel modulation signals are used for modulating in-phase (I) and quadrature phase (Q) carrier signals for transmission to a receiver via the I and Q communication channels, respectively. In a preferred implementation the receiver is operative to produce an estimate of at least the first information signal on the basis of the I-channel and Q-channel modulated carrier signals received over the I and Q communication channels. The received I-channel and Q-channel modulated carrier signals are demodulated and despread, with the resultant sequences being correlated into in-phase (I) and quadrature phase (Q) projection signals. A phase rotator operates to provide an estimate of at least the first information signal based on the I and Q projection signals and a received pilot signal.
Patent ES-2134448-T3 (ES)
Inventor: OELKERS HANS-JOACHIM
IPC: G01G19/415
Filed: 1995-03-02
Granted: 1999-10-01
Abstract: The invention concerns a combined cash register (14) and scales (11) with a common customer display (12). The electronic system of the scales only accepts those display data which are compatible with the current weighing operation.
Patent ES-2279514-T3 (ES)
Inventor: ZIMMERMANN JOSEPH
IPC: A61K38/51
Filed: 1995-07-07
Granted: 2007-08-16
Abstract: Glycosaminoglycans, including heparinases 1, 2 and 3 as well as chondroitinases AC and B from the Gram negative bacteria Flavobacterium heparinum, can be used either separately or in combination to manipulate cell proliferation. In one embodiment, heparinases are administered to degrade heparan sulfate components of the extracellular matrix, thereby allowing the heparin binding growth factors which are stored in the extracellular matrix to migrate to adjacent cells. The mobility of chemoattractant agents, growth factors and cells also can be increased by treating tissues with glycosaminoglycan degrading enzymes, both chondroitinases and heparinases. The enzymatic removal of chondroitin sulfates from cell surfaces effectively increases the availability of growth factor receptors on the cell's surface. Selectively removing heparan sulfate from cell surfaces while leaving the extracellular matrix intact, conversely, inhibits cell proliferation by down regulating the cell's response to growth factors. This is achieved by targeting heparin or heparan sulfate degrading activities to the cell surface. Targeting the heparin degrading activity can be achieved by genetically engineering a ligand binding functionality into the heparinase proteins, or by physically controlling the localized enzyme concentration through the method of administration.
Patent ES-2128753-T3 (ES)
Inventor: ERBERT KARL
IPC: A45D26/00
Filed: 1995-07-13
Granted: 1999-05-16
Abstract: Described is a device for removing hair from the human body, the device having a housing designed to be held in the user's hand, at least one preferably motor-driven rotating cylinder with hair-gripping elements and at least one device (V) for actuating the hair-gripping elements. The rotating cylinder (17) is made up of at least two segments (27, 28) which have hair-gripping elements (19, 19', ...20, 20') and which preferably extend essentially parallel to the axis (38) of the cylinder (17). The segments (27, 28) are preferably disposed so that the hair-gripping elements (19, 19', ...20, 20',...) on each segment mesh at least partly with each other.