Patent SG-11201810360Y-A (SG)
Title: Novel 5h-pyrrolo[2,3-d]pyrimidin-6(7h)-one derivative
Inventor: SUGIMOTO TETSUYA
IPC: A61P35/00
Filed: 2017-05-19
Abstract: 㻝㻜 㻌 㻝㻡 㻌 㻞㻜 㻌 㻌 Formula (I) or a salt thereof, which exhibits selected from the group consisting of Akt kinase, R 㻌 proliferation inhibiting disease s represents hetero atoms represents a hydrogen atom 㻌 one another and independently hydrogen atom independently represent different atom or the like; and 㻌 single bond one of X 㻌 The invention Formula (I) or a salt thereof, which exhibits selected from the group consisting of Akt kinase, R proliferation inhibiting s associated with the represents a - to 6 hetero atoms independently represents a hydrogen atom one another and independently hydrogen atom or the like; R independently represent different from each other and independently or the like; and single bond , and represents one of X 1 or X 2 represents N. invention of the present application Formula (I) or a salt thereof, which exhibits selected from the group consisting of Akt kinase, R proliferation inhibiting effect and is useful as a associated with the above to 6 -membered monocyclic unsaturated heterocyclic group independently represents a hydrogen atom or the like; R one another and independently or the like; R 7 independently represent a hydrogen atom from each other and independently or the like; and X3 represents N or CH when represents C when a broken line indicates a double bond, represents N. ] of the present application Formula (I) or a salt thereof, which exhibits selected from the group consisting of Akt kinase, R effect and is useful as a above -mentioned membered monocyclic unsaturated heterocyclic group independently selected from N, S and O or the like; R one another and independently represent a hydrogen atom 7 and R 8, may be the same a hydrogen atom from each other and independently represents N or CH when C when a broken line indicates a double bond, ] 㻝㻜㻤㻌 ABSTRACT of the present application Formula (I) or a salt thereof, which exhibits an inhibitory selected from the group consisting of Akt kinase, Rsk kinase, and S6K kinase effect and is useful as a prophylactic and/or therapeutic mentioned kinase membered monocyclic unsaturated heterocyclic group selected from N, S and O or the like; R 3, R 4, and R represent a hydrogen atom may be the same a hydrogen atom or the like; from each other and independently represent N or represents N or CH when C when a broken line indicates a double bond, ABSTRACT of the present application provides a compound represented by inhibitory activity selected from the group consisting of Akt kinase, Rsk kinase, and S6K kinase prophylactic and/or therapeutic kinase s, particularly membered monocyclic unsaturated heterocyclic group selected from N, S and O and may have a substituent; , and R 5, may be the same represent a hydrogen atom may be the same as or different the like; X1 and represent N or CR represents N or CH when the broken line C when a broken line indicates a double bond, provides a compound represented by activity against sk kinase, and S6K kinase prophylactic and/or therapeutic s, particularly cancer . [In the formula, membered monocyclic unsaturated heterocyclic group and may have a substituent; , may be the same as or the like; R or different from each other and and X2 may be the same CR 9; R 9 represents broken line ( C when a broken line indicates a double bond, provides a compound represented by against at least one kinase sk kinase, and S6K kinase and/or prophylactic and/or therapeutic agent for . [In the formula, membered monocyclic unsaturated heterocyclic group which ha and may have a substituent; as or different or the like; R 6 represents a from each other and may be the same represents a hydrogen ) represents C when a broken line indicates a double bond, wherein provides a compound represented by at least one kinase and/or a cell agent for . [In the formula, R1 ha s 1 to 3 and may have a substituent; R 2 or different from represents a from each other and may be the same as or a hydrogen represents a wherein at least [No Available Figure] NOVEL 5H-PYRROLO[2,3-D]PYRIMIDIN-6(7H)-ONE DERIVATIVE