baber/WOPTO huggingface dataset:
Patent PT-99084-A (PT)
Title: Process for the preparation of a shampoo composition comprising various high performance ingredients and a polyhydroxylic fatty acid amide surfactant
Inventor: BROCK EARL DAVID
IPC: A61K8/37
Filed: 1991-09-26
Abstract: A process for the preparation of shampoo compositions containing high performance ingredients such as hair conditioning agents, antidandruff agents, anti-nit agents and hair styling agents and mixtures thereof which are improved through the use of polyhydroxylic fatty acid amide surfactants is described. Amide glucose surfactants having the general formula R2C(O)N-(CH3)CH2(CH2OH)4CH2OH are among the surfactant agents disclosed for the application indicated. The polyhydroxylic fatty acid amide surfactant mentioned is present in the composition in a range of approximately 1% by weight.
Patent SE-7513879-A (SE)
Inventor: CIPRIANI G
IPC: C07C275/04
Filed: 1975-12-09
Abstract: A method for the preparation of a group of variously substituted ureas is disclosed, these compounds being obtained by the pyrolytic decomposition of the alkali metal or alkaline earth metal carbamates corresponding to the expected ureas, the reaction taking place at a temperature of between 150 DEG  and 400 DEG  C under atmospherical pressures, and preferably under subatmospherical pressures, under which conditions the expected urea either sublimes or is distilled.
Patent UA-19189-A (UA)
Title: A process for preparation of powders of refractory inorganic compounds
Filed: 1990-11-11
Abstract: The invention relates to inorganic chemistry, in particular to high temperature synthesis of refractory inorganic compounds. A process for preparation of powders of refractory inorganic compounds, e.g. carbides, nitrides, borides, sulphides comprises thermal treatment of a mixture of original components and subsequent grinding of the obtained product. The thermal treatment of original components is carried out at an action thereon of a beam of accelerated electrons.
Patent AT-A11922000-A (AT)
Inventor: REISCHER WILHELM
IPC: H02M1/32
Filed: 2000-07-11
Abstract: A protective circuit (SCH) for a line-commutated thyristor bridge (B, B'), which is designed for feeding energy of a power circuit connected to the bridge and also for feedback from this circuit, and which is connected between the thyristor bridge and the power circuit. In a series branch of the protective circuit, there is at least one IGBT transistor (GT 1, GT 2 ), which is biased in the feedback direction with an inverse-parallel diode (D 1, D 2; D 1 p), and which can be deactivated for the appearance of a tipping recognition signal (s<SUB>k</SUB>, U<SUB>s1</SUB>), which is supplied by a control circuit (AST) associated with the transistor.
Patent BG-101129-A (BG)
Title: Method for arsenic-containing waste water treatment
Inventor: YOKOSE MAMORU
IPC: C02F11/12
Filed: 1997-01-14
Abstract: The method includes the addition of an oxidant, if necessary, to the oxidation of three-valent arsenic in pentavalent one and the addition of calcium-containing substance for the adjustment of pH to 12 or higher. There follows separation of the solid and liquid phases (first separation), tempering of the sedimentation produced and the addition of ferrisalt to the treated solution to pH 6-9, and separation of the solid and liquid phases (second separation). The treated water produced meets with the requirements for maximum admissible impurities standards, and the arsenic-containing sediment (sludge) separated from the waste waters becomes harmless after subsequent stages of treatment.
Patent BG-102909-A (BG)
Title: Instant vesicular product
Inventor: HINDERIKUS MARIUS
IPC: A61K9/127
Filed: 1998-11-09
Abstract: The product of reversible vesicules contains one or morenon-ionic surfactants in powder form, optionally lipophilicstabilizing factor and a biologically active agent. It is producedby dispersion of irreversible vesicules in suitable non-polarvehiculum which is subsequently removed. The product, in a mixturewith one or more excepients, can be included in compositions.17 claims
Patent BG-104903-A (BG)
Title: Process for the preparation of resin-bound cyclic peptides
Inventor: SLEDESKI ADAM W
IPC: C07K5/078
Filed: 2000-11-02
Abstract: The invention is directed to a process for the solid phase, fragment-based synthesis of resin-bound cyclic peptide analogs of parathyroid hormones and analogs of parathyroid hormone-released proteins, which analogs contain at least one bridge between the side chains of two non-adjacent amino acid residues, and to peptide fragments useful therefor. 1 claim
Patent BG-107422-A (BG)
Title: Multivalent vaccine composition
Inventor: BOUTRIAU DOMINIQUE
IPC: A61P31/14
Filed: 2002-12-28
Abstract: A multivalent vaccine is described comprising a conjugate of the capsular polysaccharide of H influenzae b not adsorbed onto an aluminium adjuvant salt, and two or more further bacterial polysaccharides. A multi-valent vaccine composition is also described comprising a whole-cell pertussis component, tetanus toxoid, diphtheria toxoid, Hepatitis B surface antigen, a conjugate of the capsular polysaccharide of H. influenzae b, and a conjugate of a capsular polysaccharide of N. meningitidis type A or C (or both). Furthermore, a multi-valent vaccine composition is described comprising a hole-cell pertussis component, tetanus toxoid, diphtheria toxoid, and a low dose of a conjugate of the capsular polysaccharide or H. influenzae b. 29 claims, 5 figures
Patent BG-110203-A (BG)
Title: Device for control and monitoring of the parameters of fresh water and water in swimming pools
Inventor: TANEV IVAN
IPC: G05B11/01
Filed: 2008-08-22
Abstract: The device for control and monitoring of the parameters of fresh water and water in swimming pools is applied for disinfection of fresh water in water supply installations fed by water towers or by underground drills, as well as for monitoring of the physical and chemical parameters of the water in artificial swimming pools and physiotherapeutic facilities. It consists of control unit (1) connected to user interface module (2), data transfer module (3), memory module (4) and output transducer module (51, 52 ,...5m) with outputs to output terminals (6), and sensor module (7) with outputs connected to the control unit (1) via input transducer module (8). The memory block (4) has static memory (41) connected to the control module (1), and the sensor module (7) has photometer (74), ammeter cell (75) and conductivity sensor (76) with outputs connected to the input transducer module (8). The serial interface module (32) of the data transfer module (3) is connected to a local terminal (9).
Patent BG-112379-A (BG)
Title: Device for extracting atmospheric electricity
Inventor: ANGELOV IVAN
IPC: H01M4/00
Filed: 2016-09-13
Abstract: The invention relates to a device for extracting atmospheric electricity with application in the field of technics, households and anywhere where electrical energy is used. According to the device for extracting atmospheric electricity, it consists of a collector of an electric charges, with electric capacitor connected to it, which in turn is connected to a control electronics. The collector for electric atmospheric charges represents a surface of electrically conductive layers, between which there is a dielectric layer. In the volume of this surface is placed electronics for controlling the charge of the electric capacitor, as the electronics, the electric capacitor and the collector are connected to each other. The device is mobile, autonomous and with telecommunication connection and serves to implement the method. The invention contributes to expanding the possibility of usage of renewable (eco) natural sources of energy.
Patent BG-106763-A (BG)
Title: Paediatric phamaceutical composition
Inventor: BAX RICHARD P
IPC: A61K9/00
Filed: 1997-11-05
Abstract: The formulation is administered for treating bacterial infections. It is in the form of dry powder for dilution to multiple dosing suspension in water or any other suitable aqueous medium and composes amoxycillin trihydrate and potassium clavulanate in ratio 7:1. After dilution in 5 ml liquid aqueous suspension, amoxycillin from 150 to 450 mg and clavulanic acid from 25 to 75 mg is contained. It is used in a BID dosage regimen. 7 claims
Patent CN-1345697-A (CN)
Title: 一种用于水处理的光催化反应器
Inventor: WANG YIZHONG
IPC: C02F1/30
Filed: 2000-09-26
Abstract: 本发明公开了一种用于水处理的光催化反应器,其反应器容器上设有进水口、出水口和曝气口,其特征是一个带有中空套筒的锥形圆盘与水平成一定角度支撑在反应器容器上,所述的圆盘与容器壁有一定间距,在所述的套筒内有一搅拌器。本发明的光催化反应器用于废水处理,具有通用性强、工艺可调、处理废水效果好等优点。
Patent CN-1351030-A (CN)
Title: 一种新的多肽——硫酸蛋白多糖核心蛋白13.42和编码这种多肽的多核苷酸
Inventor: MAO YUMIN
IPC: C12N15/11
Filed: 2000-10-26
Abstract: 本发明公开了一种新的多肽——硫酸蛋白多糖核心蛋白13.42,编码此多肽的多核苷酸和经DNA重组技术产生这种多肽的方法。本发明还公开了此多肽用于诊治多种疾病的方法,如周期性瘫痪、心律失常、支气管哮喘、消化性溃疡、糖尿病、胚胎发育畸形、肿瘤等。本发明还公开了抗此多肽的拮抗剂及其诊治作用。本发明还公开了编码这种新的硫酸蛋白多糖核心蛋白13.42的多核苷酸的用途。
Patent CN-1348964-A (CN)
Title: 制备残余单体含量低的乳液聚合物的氧化还原方法
Inventor: BROWN S C
IPC: C08F2/16
Filed: 2001-10-17
Abstract: 一种制备水乳液聚合物的方法,包括提供至少一种烯键式不饱和单体和在乳液聚合条件下的自由基氧化还原引发剂体系,该氧化还原引发剂体系包括一种水溶性氧化剂、一种水不溶性氧化剂、和还原剂亚磺酸或其盐;并将至少一些烯键式不饱和单体进行聚合反应。本发明还提供了一种减少水乳液聚合物中残余烯键式不饱和单体含量的方法。
Patent CN-1443107-A (CN)
Title: 干式分离含有包装废弃物回收垃圾的方法和设备
Inventor: CHRITIANI J
IPC: B07B4/08
Filed: 2001-05-09
Abstract: 本发明涉及一种方法，用于干式分离含有不同聚合物族的塑料包装废弃物的回收垃圾，在多级方式中去除料流中的杂质，具有下列步骤：根据体积差异分离材料；根据颗粒形状、粒度和/或者单位重量上的差异分离材料；根据其磁特性上的差异分离材料；根据其电特性上的差异分离材料；根据其光谱特性上的差异分离材料，其中，每种分离步骤至少进行一次，其中，将回收垃圾的成分分离到一剩余料流，它含有不可再利用的剩余垃圾成分和塑料制品，从中分离出其塑料制品共同作为混合塑料材料进行分离，混合塑料材料借助于以聚合物为单位的分离法选择性地分离成基本上以聚合物为单位的材料。本发明还公开一种实施这种方法的装置。
Patent CN-1429348-A (CN)
Title: 光纤
Inventor: TAKEMI HASEGAWA
IPC: H01S3/06
Filed: 2001-05-02
Abstract: 在一种具有芯区3和围绕该芯区3的包层区5的光纤中，其中由次介质2构成的多个区在包层区5的横截面内被彼此相隔分开，该次介质2的折射率不同于构成该包层区5的主介质4的折射率，且该芯区3具有低于所述包层区5的平均折射率，而且次介质区2被沿光纤1的径向有规则地设置，使得具有给定波长、传播系数和电场分布的光沿光纤轴传播并在芯区3内具有不低于50％的总传播功率，并且这种设置在横截面上并不具有平移对称。
Patent CN-1476416-A (CN)
Title: 连续循环处理水的水处理装置
Inventor: KONLAD W E
IPC: C02F1/78
Filed: 2001-10-04
Abstract: 一种家用水处理装置，用于净化被微生物及化学物所污染的水。
Patent CN-1364858-A (CN)
Title: 阻燃润滑剂mca的制备方法
Inventor: CHEN Jin
IPC: C10M105/56
Filed: 2002-02-07
Abstract: 一种阻燃润滑剂MCA的制备方法,用等摩尔的三聚氰胺和氰尿酸在过量的水中,有一定量PVA存在条件下90～100℃反应1～2小时。反应结束后冷却、过滤、干燥得到MCA。产品无需精制其纯度大于99%,本方法收率大于97%。
Patent CN-1392626-A (CN)
Title: 控制电池充电和放电的方法
Inventor: TOSHISHI UEDA
IPC: H02J7/04
Filed: 2002-06-20
Abstract: 本发明提供一种控制电池充电和放电的方法，其中，当电池的SOC(充电状态)值在预先确定的范围内时，对电池充电和放电以使电池的SOC值增加/降低到预先确定的范围内；在其中执行充电和放电过程的SOC值的范围连续地变化，而且在充电和放电过程之后的SOC值范围也连续地变化。
Patent CN-1511351-A (CN)
Inventor: SKOTHEIM T A
IPC: H01M10/0585
Filed: 2002-05-23
Abstract: 提供一种电化学电池使用的锂阳极，其中的阳极活性层具有含金属锂的第一层和多层结构，该多层结构包括单价离子导电层和聚合物层。它们与含金属锂的第一层接触，或与含锂第一层上的例如临时保护金属层的临时保护层接触。本发明的另一内容是提供锂蒸气和反应性气体就位沉积而形成的阳极活性层。本发明阳极特别适合用于包括含硫阴极活性材料如硫元素构成的电化学电池。
Patent CN-1541106-A (CN)
Inventor: CRUZ T
IPC: A61P25/00
Filed: 2002-06-11
Abstract: 本发明公开了治疗病毒性、增殖性和炎性疾病的药物组合物，其包含与抗病毒、抗增殖和抗炎化合物联合的一定量的可药用维生素B12类化合物。维生素B12类化合物与抗病毒、抗增殖和/或抗炎化合物单独、同时或联合使用，以提供治疗病毒性、增殖性和炎性疾病的增效作用。
Patent CN-1520724-A (CN)
Inventor: ZHAO CHENGHUA
IPC: A01N37/02
Filed: 2003-01-30
Abstract: 本发明涉及一种赤松毛虫性信息素诱芯，以袖口式橡胶塞为载体，将具有赤松毛虫性信息素的己烷溶液滴加到载体上，所述的赤松毛虫性信息素包括：顺5，反7－十二碳二烯醇、顺5，反7－十二碳二烯乙酸酯和顺5，反7－十二碳二烯丙酸酯。本发明还涉及所述的赤松毛虫性信息素诱芯的用途，此诱芯在赤松毛虫发生地区或国家可用于对该害虫进行监测和通过大量诱杀进行防冶；在未发生地区或国家可用于检测是否有该物种的侵入。
Patent CN-1534029-A (CN)
Inventor: MEI JIANTING
IPC: C07D295/195
Filed: 2003-03-28
Abstract: 一种合成N－亚戊基－N’－异丙苯脲类化合物的方法，用异丙基硝基苯与哌啶在CO存在下，硒作为催化剂，叔胺为助催化剂，发生选择氧化还原羰基化生成产物，反应是在常压或在密封的高压釜中，50－200℃温度条件下进行的，异丙基硝基苯与哌啶的物料比为10∶1－1∶10mol。催化剂在该反应过程中存在相转移过程，产物与催化剂用简单的相分离就可分开，分离出的催化剂可以循环使用，在循环使用过程中，催化剂的活性基本不变甚至有所提高，反应母液也可以循环使用，且N－亚戊基－N’－异丙苯脲化合物的收率有所提高。本发明操作简便，原料易得，选择性高，产率高，产品质量稳定，后序分离容易，催化剂可循环使用。
Patent CN-1526598-A (CN)
Inventor: ZENG DEWEN
IPC: B61K9/00
Filed: 2003-09-22
Abstract: 本发明是一种铁路货车制动梁检修装夹用的制动梁悬挂式检修夹具，包括制动梁夹持机构，在制动梁夹持机构上连接有吊臂。由于本发明将制动梁夹持机构连接于吊臂，而吊臂是用于将制动梁夹持机构吊起将其悬于空中的连接件，有了这一连接件，则制动梁夹持机构可以夹持着待检修的制动梁停留于空中，使检修人员在制动梁磁粉探伤时的观察视野得以增大，便于对制动梁上的磁粉分布情况进行全面观察，此外，被制动梁夹持机构悬挂于空中的制动梁为其修理焊接提供了很大的操作空间，使检修人员能够选择到较好的焊接位置焊接平面进行焊接，因此，本发明便于检修人员对制动梁的探伤、修复，有利于简便制动梁检修操作。
Patent CN-1689339-A (CN)
Title: 3－屏透射投影系统
Inventor: DE VAAN ADRIANUS J S M
IPC: H04N9/31
Filed: 2003-09-18
Abstract: 本发明涉及一种3－屏透射投影系统。本发明尤其涉及一种对投影系统中的偏振和分解操作都施加反射型偏振器的3－屏透射投影系统。
Patent CN-1694805-A (CN)
Inventor: REINHARD HUSEMANN MARC STORBEC
IPC: C09J7/35
Filed: 2003-08-20
Abstract: 本发明涉及一种压敏胶粘带，特别是用于生产LCD显示器的压敏胶粘带，其包含两个表面，同时还提供至少一个具有两个载体表面的载体和在每个载体表面上的压敏层。本发明的特征在于压敏胶粘带的两个表面中的至少一个具有银反射性。
Patent CN-85107776-A (CN)
IPC: H02K9/28
Filed: 1985-10-26
Abstract: 适用于无刷励磁机的水冷整流环，安装在无刷励磁机转子电枢轭部的端面上，将整流部件、正、负极电路的连接线埋设在环座的孔槽内，并通水冷却。该水冷整流环具有冷却效果好、风磨损耗低、噪音小、结构紧凑、安全可靠等优点。
Patent CN-1034565-A (CN)
Inventor: GANCHENG GUO
IPC: C09D7/47
Filed: 1987-10-05
Abstract: 本发明是涉及一种改进的硝基漆稀释剂的制作
方法，本发明的方法主要是以经过净化的石脑油代替
现有硝基漆稀释剂中的苯作为冲稀剂和醋酸酯类、
C 2 、C 3 、C 4 醇类构成无致癌性硝基漆稀释剂。本发明
方法制成的产品不仅对人类具有无致癌性而且在技
术指标和经济效益上都超过目前使用的硝基漆稀释
剂。
Patent CN-1085875-A (CN)
Title: 用煤灰生产硅酸钠与氢氧化铝的方法
Inventor: FUHUA WANG
IPC: C01F7/02
Filed: 1992-10-17
Abstract: 本发明公开了一种用煤灰生产硅酸钠与氢氧化
铝的方法。现有的方法仅能回收煤灰中部分的铝，而
且工艺繁杂、有废物、液的排弃。本发明是先将煤灰
进行脱碳除铁，之后将其与氢氧化钠溶液相混合，在
提高温度、增加压力与搅动的条件下反应生成硅酸钠
稠液与氢氧化铝稀液。本法工艺简便、生产成本低，
回收率高，可将煤灰全部转化为有用的化工母本而
无任何废物、液的排放。
Patent CN-1098093-A (CN)
Inventor: AMOO VICTOR EKOW
IPC: C07D273/04
Filed: 1993-07-26
Abstract: 取代的酰胺类化合物，含有它们的农用组合物，
防治农艺和非农艺场所的节肢动物的方法，该酰胺类
化合物具有上式。 
     其中X为氧或硫，Q、G和Y如说明书中定义。
Patent CN-1109460-A (CN)
Title: 多孔颗粒状硝酸铵
Inventor: BALS EDWIN
IPC: C01C1/18
Filed: 1994-10-14
Abstract: 本发明涉及一种多孔颗粒状产品，特别是多孔颗
粒状硝酸铵，及其制备方法，该产品包括用胶囊包起
来的微球，特别是聚合物微球，所述微球是用来降低
该产品密度的。 
     本发明还提供了一种炸药组合物，尤其是硝氨燃
料油炸药(ANFO)和重ANFO，该组合物包含降低
了密度的硝酸铵。
Patent CN-1141059-A (CN)
Inventor: BISCHOFF J R
IPC: A61P1/16
Filed: 1994-11-21
Abstract: 本发明提供结合野生型和/或突变型哺乳动物p 53 蛋白质的哺乳动物多肽；编码这些多肽的多核苷酸；使用这些多肽和多核苷酸进行药物开发的筛选试验方法；具有诊断、治疗和研究用途的免疫试剂和其它试剂。
Patent CN-1145545-A (CN)
Inventor: YOSHIHIRO MORIMOTO
IPC: H02K1/17
Filed: 1995-09-14
Abstract: 本发明意于解决上述问题，而本发明的目的在于，获得一种能牢固焊接，并能稳定控制质量的磁旋转电机定子。在一种包括由永久磁性材料制成主极并由软钢材料部分制成辅助磁极的磁旋转电机的定子(它们依圆周而互相靠近，并固定在一圆柱形轭的内周上)中，辅助磁极被焊接，并固定在与辅助磁极的接合面上形成的突出部分上。
Patent CN-1140159-A (CN)
Inventor: WENZHI LIU
IPC: C05F11/08
Filed: 1996-04-29
Abstract: 本发明公开了一种新型的微生物有机无机复合肥制造方法，包括利用自然界和工农业废弃物为原料，使之部分降解成碳源及氮源，利用上述碳、氮源，繁殖酵母菌或有益真菌，使之成为复合肥料中的有机氮素营养；利用上述碳、氮源繁殖黑曲霉菌，以活化磷矿粉中部分晶格状态的束缚磷，成为速效磷，使之成为复合肥料中的磷素营养；利用上述碳源和气态氮或有机氮繁殖硅酸盐细菌，使之活化含晶格态氧化钾的矿物质诸如钾长石、明矾石粉剂，使之部分成为速效钾，形成微生物有机无机复合肥。
Patent CN-1142678-A (CN)
Inventor: KIM DAE HWANG
IPC: H01J9/20
Filed: 1996-02-17
Abstract: 本文公开了一种制造彩色阴极射线管的方法，它包括在平板内表面和荧光层之间形成颜料滤光膜的方法，其特征在于在形成所说的滤光膜的方法中包括如下步骤：在平板的内表面上涂敷包括滤光颜料，表面活化剂和纯水的第一种组合物；在所说的第一种混合物的涂层上涂敷包括重铬酸钠二水合物，聚乙烯醇和四甘醇以及纯水的第二种组合物，并进行干燥；结合阴罩进行曝光和显影。
Patent CN-1145551-A (CN)
Inventor: WITTLINGER HAROLD ALLEN
IPC: H03F3/217
Filed: 1996-08-09
Abstract: 一种D类放大器及其实现方法，其中放大器的输入信号在放大器反馈回路的外面进行了脉冲宽度调制，并且脉冲宽度调制输入信号和来自反馈回路的脉冲信号在反馈回路里叠加在一起并反馈给了放大器。由于去掉了来自反馈回路的脉冲宽度调制部分及信号积分部分，从而减小了失真。
Patent CN-1160810-A (CN)
Inventor: KOJI TSUKAMOTO
IPC: G10K11/16
Filed: 1996-10-18
Abstract: 本发明的声波相位变化装置及隔音壁目的在于，使入射声波的相位偏移大，以提高声波相互干涉造成的声波减弱效果。其措施包括将多孔材料构成的多孔构件15安装于多块隔声片12、13组合构成的隔声片组合体14的外围，并在多孔构件15的背部形成容积不同的、独立的多个空间部16。
Patent CR-20120539-A (CR)
Title: Sistema de transporte multidireccional
Inventor: QUATTLEBAUM GORDON THOMAS
IPC: B61B3/02
Filed: 2012-10-19
Abstract: Un sistema de transporte que incluye un cable principal, un ensamble de pista, y un ensamble de transporte, en donde el ensamble de pista está suspendido desde el cable principal, para permitir el movimiento de traslación no impedido del ensamble de transporte a lo largo del ensamble de pista.
Patent CR-20140289-A (CR)
Title: Derivados de quinolina como inhibidores de la enzima pde10a
Inventor: KEHLER JAN
IPC: C07D471/04
Filed: 2014-06-17
Abstract: La presente invención proporciona derivados de quinolina de fórmula I que son inhibidores de la enzima PDE10A y, como tales, son útiles para tratar trastornos psiquiátricos y eurodegenerativos. En especial, la invención proporciona compuestos que son alt
Patent CR-20170289-A (CR)
Title: Agentes inductores de apoptosis para el tratamiento de cáncer y enfermedades inmunes y autoinmunes
Inventor: WANG LE
IPC: C07D403/12
Filed: 2009-12-04
Abstract: Compuestos que inhiben la actividad de proteínas anti-apoptóticas Bcl-2, composiciones que contienen a dichos compuestos y métodos de tratamiento de enfermedades durante cuyo transcurso hay expresión de la proteína anti-apoptótica Bcl-2.
Patent CR-20210305-A (CR)
Title: 7-phenoxy-n-(3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazol-2-amine derivatives and related compounds as gamma-secretase modulators for the treatment of alzheimer's disease
Inventor: FREI BEAT
IPC: C07D487/04
Filed: 2019-12-11
Abstract: The invention provides 7-phenoxy-N-(3-azabicyclo[3.2.1]octan-8-yl) -6,7-dihydro-5H-pyrrolo[l,2-b][l,2,4]triazol-2-amine derivatives and related compounds of the general formula (I) wherein R<sup>1</sup>, Ar, n and m are as described herein, compositions including the compounds, processes of manufacturing the compounds and the compounds for use in methods of medical treatment. The present compounds are as gamma-secretase modulators for the treatment of diseases associated with the deposition of β-amyloid in the brain, such as Alzheimer's disease, cerebral amyloid angiopathy, cochlear synaptopathy, hearing loss, hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome. The present description discloses the preparation of exemplary compounds as well as pharmacological data thereof (e.g. pages 54 to 74; examples 1 to 64; table). An exemplary compound is e.g. (R)-7-(3,5-difluorophenoxy)-N- ((lR,5S,8s)-3-(6-methoxypyridazin-4-yl)-3-azabicyclo[3.2.1]octan-8-yl) -6,7-dihydro-5H-pyrrolo[l,2-b][l,2,4]triazol-2-amine (example 1).
Patent CR-20210397-A (CR)
Inventor: LIAO HAOTIAN
Filed: 2019-10-25
Abstract: Un casco con una estructura de mentonera transformable puede incluir un cuerpo de carcasa (1), una mentonera (2) y dos ramificaciones (2a) en la mentonera (2), en el que una base de soporte (3), la ramificación (2a), un engranaje interno (4), un engranaje externo (5) y un miembro de accionamiento (7) forman un mecanismo asociado, el engranaje 10 interno (4) y el engranaje externo (5) pueden girar alrededor de ejes fijos y constituyen un par de restricción de engrane, el engranaje interno (4) y la ramificación (2a) están en ajuste deslizante entre sí y constituyen un par de restricción deslizante, y el miembro de accionamiento (7) transfiere el movimiento del engranaje externo (5) a la ramificación (2a) y hace que la mentonera (2) realice un desplazamiento de extensión/retracción con 15 respecto al cuerpo de carcasa (1), de tal forma que la mentonera (2) hace un movimiento de rotación y al mismo tiempo recombina un movimiento alternativo, realizando así una transformación entre una posición de casco completo y una posición de semi-casco.
Patent CR-20220378-A (CR)
Title: Plant regulatory elements and uses thereof
Inventor: CHITTOOR JAISHREE M
IPC: C12N15/87
Filed: 2017-03-08
Abstract: The invention provides recombinant DNA molecules and constructs, as well as their nucleotide sequences, useful for modulating gene expression in plants. The invention also provides transgenic plants, plant cells, plant parts, and seeds comprising the recombinant DNA molecules operably linked to heterologous transcribable DNA molecules, as are methods of their use.
Patent EC-SP045507-A (EC)
Inventor: STIERL REINHARD
IPC: A01N43/653
Filed: 2004-12-22
Abstract: New fungicidal mixtures contain dithianon (I) and at least one 1,2,4-triazole derivative (II) in synergistic amounts, where (II) is metconazole, epoxiconazole, fluquinconazole, tebuconazole (IIa), tetraconazole, difenconazole and/or prothioconazole (preferably metconazole, epoxiconazole or (IIa)). Independent claims are included for: (1) a fungicidal composition comprising the (I)/(II) mixture plus a solid or liquid carrier; and (2) a method for controlling harmful fungi, by applying (I) and (II) to the fungi, their habitat or plants, seeds, soil, surfaces, materials or regions to be protected. ACTIVITY : Fungicide. In tests against Botrytis cinerea in paprika seedlings, (I) at 16 ppm or (IIa) at 4 ppm gave no control, whereas a combination of 16 ppm (I) and 4 ppm (IIa) gave 59% control. MECHANISM OF ACTION : Synergist.
Patent EC-SP088763-A (EC)
Title: Nuevas combinaciones terapéuticas para el tratamiento de la depresión
Inventor: ROSENZWEIG-LIPSON SHARON JOY
IPC: A61K31/4525
Filed: 2008-09-23
Abstract: Se proveen combinaciones terapéuticas útiles en el tratamiento o la prevención de la depresión y otros trastornos emocionales; composiciones farmacéuticas que contienen dichas combinaciones; y su uso en el tratamiento o la profilaxis de la depresión u otros trastornos emocionales. Dichos compuestos tienen la fórmula I: Io una de sus sales aceptables para uso farmacéutico, donde cada R1, R2, R3, R4, R5, R6, n y m son como se definen y se describen en esta solicitud.
Patent EC-SP972011-A (EC)
Title: Composicion masticable confitada y metodo de preparacion
Inventor: GRAFF ALLAN H
IPC: A23L2/60
Filed: 1997-01-29
Abstract: La presente invención propociona un producto masticable confitado con un centro y una cobertura externa caracterizado porque: a) Dicho centro comprende una composición de goma de mascar con una base de goma de mascar, un edulcorante, un suavizante y un saborizante; y b) Dicha cobertura externa comprende una composición blanda confitada con un edulcorante, agente de flexibilización y un contenido graso de 0 al 7% en peso de dicha composición. La presente invención además proporciona métodos para la preparación de dicho producto masticable confitado.
Patent FR-1601053-A (FR)
Title: Epimerisation of 11-keto-5a 9a 10a-steroids
IPC: A61K31/566
Filed: 1963-10-11
Granted: 1970-08-10
Abstract: Process:- (I) (when Y=OH, oxidation with CrO3 gives Y=O) Hydrogenation is carried out at 1-120 atmos., temp. 80-170 deg.C, for 5-30 hrs. using Pt, Ru, Pd or Ni optionally in the presence of acid if there is no 3-alkoxy-DELTA2,5(10)-moiety present. R and R' = H or lower alkyl group R2 = lower alkyl group X and Y = alpha- or beta-OH or ketone Z = OH, lower alkoxy, or keto group indicates that the substituent attached to the steroid nucleus may be alpha- or beta-. The partial structures are those of steroids of the oestrane or pregnane series. indicates that the configuration at C-9 is beta. Cpds. of the 19-nor-5alpha,9beta,10alpha-oestrane series are anabolic agents and sedatives of the CNS. The compounds of the 19-nor-5alpha,9beta,10alpha-pregnane series are oral progestational agents useful in the control of fertility. They also reduce cholesterol level in the blood.
Patent FR-1602307-A (FR)
Title: Wet or dry polishing fabric
IPC: B24D11/02
Filed: 1968-10-22
Granted: 1970-11-09
Abstract: Fabric comprises (1) a stiffened carrier fabric (2) an intermediate elastic layer, and (3) a resinous binder layer for the abrasive particles. (2) is a curable mixture of (a) a 4,4'-dihydroxy-diphenyl-2,2-propane based epoxy resin (pref. 10 pbw) (b) an epoxy resin based on (a) which is internally plasticised by reacting with ricin oil (pref. 90 ppw) (c) alkyl carbamidate (pref. 0.5 pbw) and (d) curing agents.