baber/WOPTO huggingface dataset:
Patent BR-112023015177-A2 (BR)
Title: Ácido nucleico compreendendo smn1 e mir-23a para tratamento da atrofia muscular espinhal, cassete de expressão, vetor de expressão, vírus recombinante, composição farmacêutica, uso e método relacionados
Inventor: GERSHOVICH PAVEL MIKHAILOVICH
IPC: C12N7/01
Filed: 2022-01-28
Abstract: ácido nucleico compreendendo smn1 e mir-23a para tratamento da atrofia muscular espinhal, cassete de expressão, vetor de expressão, vírus recombinante, composição farmacêutica, uso e método relacionados. o presente pedido refere-se aos campos de biotecnologia, virologia, genética e biologia molecular. mais especificamente, a presente invenção refere-se a um ácido nucleico isolado para produzir um produto viral de terapia gênica, o referido ácido nucleico isolado compreendendo um ácido nucleico que codifica a proteína smn1 possuindo a sequência de aminoácidos de seq id no: 1 e um ácido nucleico que codifica o microrna mir-23a, um cassete de expressão e um vetor baseado no mesmo, bem como um vírus recombinante baseado em aav9 para expressar o gene smn1 em células alvo, uma composição farmacêutica que inclui o referido vírus recombinante e vários usos do vírus recombinante acima e dos anteriores composição.
Patent BR-112023015283-A2 (BR)
Title: Composição de análogo de queijo, produto alimentício, uso de uma composição de gordura, e, processo de fabricação de uma composição
Inventor: MADS CLAUSEN PEDERSON
IPC: A23C20/02
Filed: 2022-01-28
Abstract: composição de análogo de queijo, produto alimentício, uso de uma composição de gordura, e, processo de fabricação de uma composição. uma composição de análogo de queijo compreende de 20% a 30% em peso de uma composição de gordura; de 1% a 45% em peso de um amido; de 0% a 15% em peso de proteína não animal; e de 35% a 65% em peso de água; em que a porcentagem em peso combinada de amido e proteína não animal na composição não excede 45%; em que a composição de gordura compreende de 20% a 85% em peso de resíduos de ácidos graxos saturados; de 10% a 50% em peso de resíduos de ácido esteárico (c18:0); e de 2% a 35% em peso de resíduos de ácido láurico (c12:0); em que as ditas porcentagens de resíduos de ácidos graxos se referem a ácidos graxos ligados como grupos acila em glicerídeos na composição de gordura e sendo baseados no peso total de resíduos de ácidos graxos c4 a c24 ligados como grupos acila presentes na composição de gordura.
Patent SK-3994-A3 (SK)
Title: One-way disc valve
Inventor: DEBUSH GEORGE
IPC: F16K15/08
Filed: 1994-01-12
Abstract: A one-way valve for dispensing fluid assures, after the fluid has been dispensed, that any flow of contaminants into the source of the fluid is prevented. The one-way valve has a disc shaped valve body enclosed about the circumferential edge by an elastomeric membrane. Separate passageways conduct the fluid through the valve body with the fluid flowing from one passageway to the other between the circumferential edge and the elastomeric membrane. The valve body has a greater diameter than axial length.
Patent CH-623979G-A3 (CH)
Title: Machine for thermoforming watch glasses
IPC: G04D3/06
Filed: 1979-01-16
Abstract: This machine includes two rotary transfer devices (4, 18), one transporting glass blanks and the other the formed glasses. A drive device (6 to 15) indexes these transfer devices (4, 18) which are arranged so that for each indexing position two settings (5, 20) are aligned. A forming device (22 to 25) aligned on these settings includes a punch and a die. The transfer device carrying the blanks is situated partially in a heated enclosure. The rate of manufacture of watch glasses is increased as is the flexibility of use of the machine. <IMAGE>
Patent CZ-37492-A3 (CZ)
Inventor: DRAZO JULIUS ING
IPC: B61F5/38
Filed: 1992-02-10
Abstract: Dvojnápravový podvozok koíajových vozov s tuhými,súkolesiami
je určený hlavně na úzkorozchodné osobné vozy v
banských podmienkach pre zvýšenie bezpečnosti prevádzky.
Dve tuhé súkolesenia (1) sú na oboch stranách
koncami náprav (2) s výklopnými ložiskami (4) uložené vo
výkyvných ramenách (3), ktoré sú navzájom spojené nosníkom
(5) otočné vo zvislých rovnoběžných rovinách pomocou
čapov (6).
Patent CZ-41499-A3 (CZ)
Title: Unit consisting of electric motor and working machine driven thereby
Inventor: BURGDORF JOCHEN
IPC: H02K7/14
Filed: 1997-06-26
Abstract: The assembly has a piston driven by an eccentric mechanism and an electric motor which can be separated from the machine for test running. The motor drive shaft (4) and the machine's axle (10) are made separately and the machine axle carries a three-ring bearing (11) with an eccentric intermediate ring (13). The intermediate ring is shape- and/or force-locked to the drive shaft.
Patent CZ-44597-A3 (CZ)
Title: Multi-purpose auxiliary apparatus for producing, repairing and renovating helicoids of worms
Inventor: OTT ROSTISLAV ING CSC
IPC: B23B5/46
Filed: 1997-02-13
Abstract: The screw (12) is held and supported on a vertically adjustable auxiliary bearing by means of a positioning stock (6), rest and chuck of the spindle (8) fitted in the spindle head (9), which is positioned and driven dependently by the controlled drive (11). The spinning movement of the spindle (8) is linked in terms of position to the resulting movement of the positioning device (21) and the required upward gradient of the worked screw (12). The positioning device (21) is held and supported by the upper swivel support (15) and allows adjustment of the milling, grinding or polishing spindle head (16) to the required position, which is detented. In case of depositing used screws or armouring the functional surface of newly made screws the positioning device (21) is equipped with a depositing device. The multifunctional ancillary equipment can serve for ongoing assessment of the screw axis deformation as a result of heat and mechanical strain during depositing and machining, since the positioning device (21) is fitted with a digital indication device for measuring run-out, which is linked to the dependently controlled drive (11).<IMAGE>
Patent CZ-63699-A3 (CZ)
Title: Compounds based on amides of phosphinic acid as inhibitors of intercellular matter metalloproteases, process of their preparation and their use as medicaments
Inventor: PIKUL STANISLAW
IPC: A61P17/00
Filed: 1997-08-22
Abstract: The invention provides compounds which are useful as inhibitors of matrix matalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a structure according to formula (I) wherein R1, R2, R3 and R4 are described in the claims, a stereoisomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable alkoxyamide, ester acyloxyamide, imide or derivative thereof. Also disclosed are compounds, pharmaceutical compositions and methods of treating diseases characterized by matrix metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
Patent SK-37092-A3 (SK)
Inventor: ZVERKA ROBERT
IPC: G01F11/00
Filed: 1992-02-10
Abstract: Automatický prístroj pozostáva z uzatváratelnej
kalibrovanej skúmavky (9) s uzatváratelným výtokovým
otvorom (12),ktorá je uložená na preklápacom
člene (13) a do ktorej spoločne vyúsťuje dávkovací
člen (2) mlieka a dávkovací člen (4) reagenčného
roztoku. Pod výtokovým otvorom (12) je umiestnená
meracia nádobka (15) vybavená uzatváratelným
výpustom (16) a snímačom (15) výšky hladiny spojeným
s riadiacou jednotkou (17). Pod dávkovacia
členom (2) mlieka a dávkovacím členom (4) reagenčného
detergentného roztoku môže byť umiestnená odmerka
(5) mlieka a odmerka (6) reagenčného detergentného
roztoku so spoločným vyústením do lievika
(8). Qdmerky môžu byť uložené na do seba zaberajúcich
ozubených kolesách (18), z ktorých jedno je
ozubením spojené s hnacím clenom.
Patent SK-40493-A3 (SK)
Title: Polycitraconimide and polyitaconimide with content (poly)sulfide groups
Inventor: HOGT ANDREAS H
IPC: C07D207/444
Filed: 1991-10-29
Abstract: Novel (poly)sulfide-containing polycitraconimides and polyitaconimides are disclosed. Further, a process for the sulfur-vulcanization of rubber using these novel polycitraconimides and polyitaconimides is also disclosed. Also, a sulfur-vulcanized rubber product and articles of manufacture embodying this product are disclosed. Finally, the use of the novel (poly)sulfide-containing polycitraconimides and polyitaconimides as anti-reversion coagents in the sulfur-vulcanization of rubber is also disclosed.
Patent SK-49895-A3 (SK)
Title: Moulding of aperture articles
Inventor: CORCORAN TERENCE
IPC: B30B15/02
Filed: 1993-10-05
Abstract: An article (10) having side holes (11), e.g. a spacer (10) for a central heating radiator, is made of compacted loose particulate material in a die comprising a plate (1) having a vertical cavity (2), a top punch (7) and a bottom punch (4). An inner core rod (3) forms a central passageway (12) in the spacer (10) and side core rods (6) form the side holes (11). The density of the compacted material defining the side holes (11) is higher than in the remainder of the article.
Patent SK-65497-A3 (SK)
Title: Compost decontamination of ddt contaminated soil
Inventor: BERNIER ROGER L
IPC: A62D3/38
Filed: 1996-09-23
Abstract: The present invention provides a process of decontaminating soil and/or sediments containing DDT type contaminants by converting these contaminants into harmless materials thereby decontaminating the soil to whatever extent desired, either partial decontamination or complete remediation. The process comprises treating solid and/or sediment which contains populations of viable anaerobic and aerobic microbes capable of transforming DDT type contaminants into harmless materials and being viable under both anaerobic and aerobic conditions.
Patent CS-173191-A3 (CS)
Title: Mixtures of dichloropentafluoropropane, methanol and a hydrocarbon containing six carbon atoms, exhibiting azeotropic behavior
Inventor: MAGID HILLEL
IPC: C11D7/50
Filed: 1991-06-06
Abstract: Novel azeotrope-like compositions comprising dichloropentafluoropropane, methanol, and a hydrocarbon containing six carbon atoms which are useful in a variety of industrial cleaning applications including cold cleaning and defluxing of printed circuit boards.
Patent CZ-329091-A3 (CZ)
Inventor: KRAVCIV MILOS MUDR
IPC: A61K9/20
Filed: 1991-10-30
Abstract: Léková forma s obsahem chininu a jeho solí pro perorální
aplikaci, mající antivirový účinek, jejíž podstata spočívá v
tom, že obsahuje jako účinnou látku 10 až 50 % hmot. chininu
nebo jeho solí, 30 až 50 % hmot. plniva, 30 až 60 %
hmot. pojiv, 5 až 20 % hmot. látek zvyšujících rozpad, 1 až
10 % hmot. kluzných látek, 0,25 až 2 % hmot. antiadhesiv,
případné laky, barviva a leš- tiva v rozsahu 0,001 až 1 %
hmot., popřípadě filmotvomé látky.
Patent CZ-368991-A3 (CZ)
Inventor: JURECKA JAN
IPC: C10B1/04
Filed: 1991-12-05
Abstract: Válcovité téleso (1) pece je ve své spodní části radiálně po svém obvodu opatřené průduchy (9) se sacími klapkami (10). V krytu (3) pece je vytvořen osový otvor (32) s ustavenou klapkou (4). V tělese (1) pece jsou vzduchotěsné zabudovány dveře (5)
Patent CZ-439090-A3 (CZ)
Title: Derivatives of 4-benzoylisoxazole, process and intermediates for their preparation, herbicidal agent in which they are comprised and method of suppressing growth of weed by making use thereof
Inventor: ROBERTS DAVID ALAN
IPC: C07C49/813
Filed: 1990-09-10
Abstract: Compounds of formula <CHEM>  wherein R<1> represents: an optionally substituted alkyl, alkenyl, or alkynyl group ; or an optionally substituted cycloalkyl group; or an optionally substituted cycloalkenyl group ; or a group such as aryl, aralkyl, COOR<3>, COR<3>, CN, NO<2>, NR<3>R<4>, OR<5>, halogen atom. R2 represents a group such as NO<2>, CN, R<5>, S(O)mR<5>, SO2NR<3>R<4>, COOR<3>, COR<3>, CONR<3>R<4>, CSNR<3>R<4>, OR<5>, or alkyl substituted by OR<5>, or a halogen atom.  R<3> and R<4> represent H or an optionally substituted alkyl.  R<5> represents an optionally substituted alkyl  m represents zero, 1 or 2  n represents an integer from 1 to 5  p represents zero or 1 and agriculturally acceptable salts thereof. The herbicidal composition comprising these compounds and their application to crop protection.
Patent CZ-9901082-A3 (CZ)
Inventor: VONTOR TOMAS DOC DR ING CSC
IPC: A61L15/18
Filed: 1999-03-26
Abstract: Absorbující krycí obvaz z aktivní uhlíkové textilie, slouží k
léčení trofických ran, ulcerosních ran, zhnisaných ploch a
různé etiologie, komplikovaných pooperačních ran s
bakteriální kontaminací. Dále slouží k eliminaci nepříjemného
zápachu. Kryt je netoxický, nedráždivý, dobře přizpůsobitelný
tvaru rány, snadno odstranitelný, přejímá kromě exudátu také
bakterie, toxiny, proteiny a látky zprostředkující zánětlivé
procesy. Dvouvrstvý obvaz je tvořen inaktivní nosnou vrstvou
bílé netkané textilie a účinnou vrstvou černého sorbentu.
Sorbentje uhlíková tkanina s makroskopicky hladkým
povrchem, jejíž vlákna jsou termicky zpracována při vyšších
teplotách. Výsledný krycí obvaz je sterilizován gama paprsky
Patent CZ-124897-A3 (CZ)
Title: Oral cyclosporin preparation
Inventor: CHO MOO J
IPC: A61K47/34
Filed: 1996-07-31
Abstract: Improved oral cyclosporin formulations which have high bioavailability and are capable of administration in hard capsules or nanoparticles are provided. In the subject formulations, cyclosporin is delivered in an orally acceptable vehicle comprising at least one alkanol solvent of from 2 to 3 carbon atoms in combination with at least one non-ionic surfactant. The subject formulations may further comprise at least one cosolvent, where cosolvents of interest include fatty acids and diols. The subject formulations find use in immuno-suppressive therapy.
Patent CZ-153598-A3 (CZ)
Title: Novel herbicidal agents containing 4-benzoylisoxazoles and aclonifen
Inventor: LEROUX BERNARD
IPC: A01N43/80
Filed: 1996-11-13
Abstract: The invention relates to compositions comprising: (a) a 4-benzoylisoxazole of formula (I) wherein R is hydrogen or -CO2R<3>; R<1> is cyclopropyl; R<2> is selected from halogen, -S(O)pMe and C1-6 alkyl or haloalkyl; n is two or three; p is zero, one or two; and R<3> is C1-4 alkyl; and (b) 2-chloro-6-nitro-3-phenoxyaniline, which is aclonifen; and to their use as herbicides.
Patent CZ-187898-A3 (CZ)
Title: Abrasive cutting and grinding wheel
Inventor: NEMES STEFAN
IPC: B24D3/28
Filed: 1997-09-08
Abstract: Abrasive cutting and grinding wheels which are resin bonded and reinforced with glass fiber nets, and which obligatory contain one part of abrasive in the form of abrasive lumps obtained by cold treatment of remains of resin bonded grinding wheels with dry mechanical procedure of crushing, sieving and airing, resolve the ecological problem of resin bonded grinding wheels waste in a simple, inexpensive and effective way. At the same time, resin bonded cutting and grinding wheels of higher quality are produced, i.e. grinding wheels with smaller specific gravity, more flexible structure and better grinding effects.
Patent CZ-221497-A3 (CZ)
Title: Method of determining behavior of a liquid scum
Inventor: PRINS ALBERTUS
IPC: G01N33/00
Filed: 1996-01-11
Abstract: The invention relates to a method for determining foaming behaviour of a liquid by means of a gas, which comprises supplying the gas to an amount of the substantially gas-free liquid to form a foam and analysing one or more properties of the foam, wherein the gas is supplied through a grid provided with holes having a diameter of 25 to 100  mu m, which holes are located at a mutual distance of 5 to 15 times the diameter of the holes.
Patent CZ-232393-A3 (CZ)
Title: Apparatus for removing rakings from huge quantities of water
Inventor: HUBER HANS GEORG
IPC: B01D29/64
Filed: 1993-11-02
Abstract: A device for cleaning large quantities (3) of water from debris at overflow edges (2) has a separating surface (10) which is arranged in a stationary position and through which the quantity of water flows. The separating surface (10) is designed as a piece of a cylinder circumference (7) with an axis (8) lying parallel to the overflow edge (2). Allocated to the separating surface (10) is a receiving unit (11) driven about the axis (8) of the cylinder circumference (7) for removing the debris separated at the separating surface (10). <IMAGE>
Patent CZ-9902505-A3 (CZ)
Title: Spray container
Inventor: LUND MARK THOMAS
IPC: B65D83/16
Filed: 1998-01-14
Abstract: Disclosed is a spray package (10) having a container body (12), an actuator (16), and a shroud (14) between the container body (10) and the actuator (16). The actuator (16) has a nozzle (22), and is adjustable between a locked position and an unlocked position by rotation of the nozzle (22) about the actuator's longitudinal axis. The unlocked position allows vertical movement of the actuator (16) for dispensing product from the package (10), and the locked position prevents vertical movement of the actuator (16) to prohibit dispensing of product from the package (10). The locked position simultaneously provides cooperation between the nozzle (22) and an anti-clog member (18), connected to and extending above the shroud (14). The anti-clog member (18) has a nozzle seal (46) on its inside surface which inhibits clogging of product within and about the nozzle (22) when the seal (46) is in contact with the nozzle (22).
Patent CZ-284994-A3 (CZ)
Title: Analogs of gaba and l-glutamic acid
Inventor: SILVERMAN RICHARD B
IPC: C07C317/44
Filed: 1993-05-18
Abstract: A compound of formula (I) wherein R1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R2 is hydrogen or methyl; and R3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are also disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are further disclosed.
Patent CZ-293599-A3 (CZ)
Inventor: SHAI YECHIEL
IPC: C07K14/435
Filed: 1998-02-19
Abstract: Nehemolytická cytolytická činidla volená z peptidů, komplexů
provázaných peptidů, směsí peptidů nebo nahodilých
kopolymerů peptidů mající selektivní cytolytické účinky na
patogenní buňky, které se v těle nevyskytují přirozeně,
zahrnující mikrobiální patogenní organismy a zhoubné buňky,
přičemž tato činidlajsou nehemolytická, nemají žádné
cytolytické účinky na červené krevní buňky. Peptidymohou
představovat cyklické deriváty přírodních peptidů, takových
jako pardaxin a mellitin ajejich částí, ve kteiých L-amino
kyselinové zbytkyjsou zaměněny odpovídajícími D-amino
kyselinovými zbytky, nebo představují diastereomeiy
lineárních peptidů tvořené různými poměry alespoňjedné
pozitivně nabité amino kyseliny a alespoňjedné hydrofobní
amino kyseliny, ve kterých alespoňjeden z amino
kyselinových zbytkůje LLamino kyselina. Faramaceutické
prostředky obsahující nehemocytolytická činidla mohou být
použity pro ošetření různých chorob způsobených patogeny,
jako bakteriální, plísňové, virové infekce, mykoplasma a infekce způsobené prvoky a pro ošetření rakoviny
Patent CZ-384998-A3 (CZ)
Title: System of connecting ring-shaped tyre with rotating drum, such as rotary furnace
Inventor: BONIN JACQUES LOUIS
IPC: A23N12/08
Filed: 1998-11-25
Abstract: The connecting system between an annular binding (1) and a rotary drum (10) consists of wedges (2a, 2b) which are set in pairs parallel to the axis of the drum and capable of application against opposite side faces (14, 15) of the binding and held in place tangentially by retaining members fixed to the drum. The wedges in each pair have sections (8) which are inserted beneath the binding, connected to raised portions (9) with faces (16, 17) which are held against the corresponding side faces of the binding. The wedges in each pair are connected by locking members which are independent of the binding and pass at least partly through their sections beneath the binding to lock the binding tightly between the thrust faces of their raised portions. The tensioners (4) for the wedges are located alternately on opposite sides of the binding.
Patent ES-8707546-A3 (ES)
Title: Androstane series dehydro-steroid prepn.
IPC: C07J1/00
Filed: 1985-12-20
Abstract: A 9(11)-dehydro steroid, used in prepn. of cortico-steroids, is made by (a) dissolving a 9 alpha-hydroxy androstane in an organic base and reacting with benzene sulphonyl chloride; and (b) dissolving the androstane benzeno-sulphinate formed in chloroform, adding an organic acid and silica gel and heating under reflux.
Patent SK-104999-A3 (SK)
Title: Method for the treatment of municipal sewage waters
Inventor: BODIK IGOR
IPC: C02F3/28
Filed: 1999-08-02
Abstract: A method of treatment of municipal waste-waters from which coarse impurities have been removed using anaerobic treatment process and a carrier, consists in that after removal of insoluble substances in the first stage, the municipal waste-water is treated stepwise in at least three next stages by anaerobic treatment comprising attached biomass with a hydraulic retention time of 6 to 48 hours, and subsequently it is subjected to oxic treatment process (6) with a hydraulic retention time of 0.2 to 12 hours, while the anaerobic and oxic removal take place in the presence of a biomass carrier having a specific surface of 60 to 500 m2/m3. The municipal waste-water proceeds through the individual stages of the anaerobic process either from below upwards or from above downwards. At the oxic treatment biomass is intensively aerated with pressure air, and after the oxic treatment the waste-water may be, together with the built-up biomass, recycled into at least one of the anaerobic stages.
Patent SK-107998-A3 (SK)
Title: Variants of thymidine kinase, related nucleic acids sequences and their use in genic therapy
Inventor: CROUZET JOEL
IPC: A61K31/711
Filed: 1997-01-31
Abstract: The present invention relates to a nucleic acid sequence characterized in that it is derived from the wild nucleic acid sequence coding for a thymidine kinase, said nucleic acid sequence having at least one mutation in the region corresponding to the ATP binding site and conveniently a second mutation in the N-terminal region and/or C-terminal region. It also relates to variants of the wild thymidine kinase and their uses in genic therapy.
Patent SK-140995-A3 (SK)
Title: Reluctance motor, in particular for driving and washing machine
Inventor: KLEIN HANS-WILHELM
IPC: D06F37/30
Filed: 1994-04-28
Abstract: For reducing the operating noise of the reluctance motor with rotor poles (2.1), with smaller magnetic resistance, divided on periphery of the rotor there are made recesses (5) with increased magnetic resistance. The recesses (5), at least on the side turned to the periphery of the rotor, are equipped by filling (2.11; 3) for creating plain periphery surface to prevent making the noise following whirling of the surroundings, which is magnetically conductive, preventing making the noise by magnetostriction, eventually by moment pulsation occurring in operation during rotating of the rotor related to the stator.
Patent SK-146994-A3 (SK)
Title: 9a-n-/n'-carbamoyl and 9a-n-/n'-thiocarbamoyl/ derivatives 9-deoxo-9a-aza-9a-homoerythromycin a
Inventor: KUJUNDZIC NEDJELJKO
IPC: A61P31/04
Filed: 1994-11-30
Abstract: The invention relates to 9a-N-(N'-carbamoyl) and 9a-N-(N'-thiocarbamoyl) derivatives of 9-deoxo-9a-aza-9a-homoerythromycin A, novel semisynthetic macrolide antibiotics of the azalide series, of the formula (I) <CHEM> wherein R represents a C1-C3 alkyl, aryl or aralkyl group and X represents O or S, and pharmaceutically acceptable addition salts thereof with inorganic or organic acids, to the intermediates and processes for the preparation thereof, to a process for the preparation of pharmaceutical compositions as well as to the use of pharmaceutical compositions in the treatment of bacterial infections.