baber/WOPTO huggingface dataset:
Patent NZ-594847-A (NZ)
Title: Benzofuran derivatives
Inventor: TSUKAMOTO TETSUYA
IPC: A61K31/496
Filed: 2010-03-09
Abstract: Abstract 594847 The present disclosure provides a compound represented by the following formula (I): wherein: Ring A represents an optionally substituted piperazine ring, an optionally substituted morpholine ring, or an optionally substituted bomopiperazine ring; R1 and R2 are the same or different from each other, and represent a hydrogen atom or optionally substituted lower alkyl; R3 and R4 are the same or different from each other, and represent a hydrogen atom or halogenated or non-halogenated lower alkyl; R3 to R7 are the same or different from each other, and represent a hydrogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted cycIoaJkyl, optionally substituted aryl, an optionally substituted aromatic heterocyclic ring, optionally substituted amino, or acyl; and represents a single bond or double bond, wherein R2 and R3 do not exist when carbon atoms respectively adjacent to R2: and R3 form a double bond, and there is no case where all of R1 to R7 are hydrogen atoms, and R1 and R2; may form a ring together with an adjacent carbon atom; or a salt thereof. Compounds of the disclosure include: 1-(4-Methoxyphenyl)-4-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine 1-(4-Methoxyphenyl)-4-[(2R)-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl]piperazine 1-(4-Methoxyphenyl)-4-[(2S)-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl]piperazine 1-(4-Methoxyphenyl)-4-(7-methoxy-2,2,4,6-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine 1-(4-Ethoxyphenyl)-4-(7-methoxy-2,2,4,6-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine (-)-{ 5-[4-(4-methoxyphenyl)piperazin-1-yl]-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-2-yl} methanol and (+)-{ 5-[4-(4-methoxyphenyl)piperazin-1-yl]-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-2-yl} methanol
Patent NZ-606977-A (NZ)
Title: Combination pharmaceutical composition and methods of treating diseases or conditions associated with respiratory disease or condition
Inventor: EPSHTEIN OLEG ILIICH
IPC: C07K16/44
Filed: 2011-07-15
Abstract: Disclosed is a combination pharmaceutical composition comprising a) a homeopathic activated-potentiated form of an antibody to bradykinin, b) an activated-potentiated form of an antibody to histamine and c) a homeopathic activated-potentiated form of an antibody to morphine. Also disclosed is the use of a) a homeopathic activated-potentiated form of an antibody to bradykinin, b) a homeopathic activated-potentiated form of an antibody to histamine and c) a homeopathic activated-potentiated form of an antibody to morphine in the manufacture of a medicament for treating and preventing upper respiratory tract conditions or disorders and the symptoms associated therewith by administration of the combination composition.
Patent NZ-607498-A (NZ)
Title: Biomaterials with enhanced properties and devices made therefrom
Inventor: CUNANAN CRYSTAL M
IPC: A61L31/00
Filed: 2011-08-24
Abstract: Discloses an isolated and chemically treated portion of calf pericardium tissue comprising: an elastin content greater than 0.25 micrograms per milligram dry weight, a ratio of hydroxyproline to proline greater than 1.0, wherein the calf is less than 12 months old; and wherein amino acid residues in the tissue portion are synthetically, chemically cross-linked with glutaraldehyde.
Patent NZ-609173-A (NZ)
Title: Tool for clamping using end faces of workpieces
Inventor: YANZHAO ZHU
IPC: B60N2/90
Filed: 2012-06-04
Abstract: The end face (first end) of a gear box casing is held up against the underside of an upper template 1 and a support rod 19, 20 is moved beneath the casing by rotation of the shaft 12 via a rotatable knob B to support the casing against the underside of the template plate 1. The shaft 12 is provided with a compression spring between the knob and the top side of the template to provide an upward spring force on the rod 19. Alignment pins are inserted through holes in the template into the upper end of the casing to laterally align the casing with the template and then the casing is clamped up firmly against the underside of the template by a jack 7 acting on a connecting block 9 and a triangular array of protrusions 11 which press against the underside (other end) of the casing. The hinged connection between the top plate 10 and the connection block 9 and the triangular array of protrusions allow for firm clamping of the casing against the underside of the template despite that the lower end face of the casing may not be even. The internal upward facing space within the casing may then be accurately machined by a tool projecting through apertures within the template.
Patent NZ-614043-A (NZ)
Title: Sustainable method and system for treating water bodies affected by bacteria and microalgae at low cost
Inventor: FISCHMANN TORRES FERNANDO BENJAMIN
IPC: C02F103/02
Filed: 2011-09-12
Abstract: The disclosure relates to a sustainable method for treating and maintaining a body of water affected by bacteria and microalgae at low cost by filtering a small fraction of the total volume of the body of water, the method comprising collecting water, storing said water, limiting the density of bathers, within periods of 7 days, and for water temperatures up to 45 degrees Celsius, maintaining said waters ORP of at least 500 mV for a minimum period of 1 hour for each degree Celsius of water temperature, by adding disinfectant agents to the water, suctioning a portion of said water containing settled particles produced by the previous processes with a mobile suction means to prevent the thickness of settled material from exceeding an average of 3 mm, filtering the water and returning the filtered water. The disclosed system filters only a small fraction of the total water volume, up to 200 times less per day than the flow filtered by conventional swimming pool filtration systems. The disclosed methods and system also use less chemicals than conventional swimming pool water treatment systems.
Patent NZ-621210-A (NZ)
Title: Process for preparing 5-(2-{ [6-(2,2-difluoro-2-phenylethoxy)hexyl]amino} -1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via a novel intermediate
Inventor: MARCHUETA HEREU IOLANDA
IPC: C07D215/26
Filed: 2012-10-02
Abstract: The present disclosure is concerned with a process for preparing a 5-(2-{ [6-(2,2-difluoro-2-phenylethoxy)hexyl]amino} -1(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one compound of formula (I) or a pharmaceutically acceptable salt thereof. The process of the present disclosure provides for each of a reduction step and the deprotection step to be performed in a single step in easily attained reaction conditions.
Patent NZ-628014-A (NZ)
Title: Recombinant factor viii proteins
Inventor: KULMAN JOHN
IPC: A61K38/37
Filed: 2013-02-15
Abstract: Disclosed is a recombinant FVIII protein comprising: a first polypeptide comprising Formula I: (Al) — al — (A2) — a2 — [B]; and a second polypeptide comprising Formula II: a3 — (A3) — (C1), wherein the first polypeptide and the second polypeptide are fused or exist as a heterodimer, wherein: (a) A1 is an A1 domain of FVIII; (b) A2 is an A2 domain of FVIII; (c) [B] is a B domain of FVIII, a fragment thereof or is deleted; (d) A3 is an A3 domain of FVIII; (e) C1 is a C1 domain of FVIII; and (f) al, a2 and a3 are acidic spacer regions, wherein the Al domain comprises a permissive loop-1 (A1-1) region and a permissive loop-2 (A1-2) region, wherein the A2 domain comprises a permissive loop-1 (A2-1) region and a permissive loop-2 (A2-2) region, wherein the A3 domain comprises a permissive loop-1 (A3-1) region and a permissive loop-2 (A3-2) region, wherein at least one of regions A1-1, A1-2, A2-1, A2-2, A3-1 or A3-2 comprises a heterologous moiety, and wherein the recombinant FVIII protein exhibits procoagulant activity.
Patent NZ-629598-A (NZ)
Title: Stable bioactive substances and methods of making
Inventor: HAREL MOTI
IPC: A61K47/36
Filed: 2014-03-07
Abstract: Discloses a method for preparing a stable bioactive substance comprising a bioactive material, comprising; (a) adsorbing the bioactive material in a solution onto dry particles comprising one or more water soluble gums, whereby bioactive loaded particles are formed; and (b) drying the bioactive loaded particles, whereby the stable bioactive substance is obtained.
Patent NZ-710076-A (NZ)
Title: Hand-held device for electrically powered skin treatment
Inventor: GIMELLI BRUNO
IPC: A61N1/32
Filed: 2014-01-16
Abstract: A hand-held device for electrically powered skin treatment is presented in which an electrical current is guided into the skin via an electrode (3) so that active ingredients from a cream applied previously to the skin can better penetrate into the skin. The device is equipped with a charging circuit and rechargeable batteries (73) which are accommodated in a compartment (72) at the bottom of the device. This compartment (72) is covered by a compartment cover (77) on which a connector socket (82) is arranged which can be connected with an external power source for charging the batteries (73). A housing cover (75) is arranged over the compartment cover (77). The housing cover (75) is flush with the outer contour of the device housing.
Patent NZ-710248-A (NZ)
Title: Therapeutic and diagnostic target for cancer comprising dll3 binding reagents
Inventor: HUDSON LINDSEY JANE
IPC: G01N33/574
Filed: 2014-02-12
Abstract: The present disclosure provides methods and compositions for treatment, screening, diagnosis and prognosis of cancer, such as lung cancer, pancreatic cancer and skin cancer, for monitoring the effectiveness of cancer, such as lung cancer, pancreatic cancer and skin cancer treatment, and for drug development.
Patent NZ-712049-A (NZ)
Title: A Support Assembly
Inventor: GREG BLOOM
IPC: E04H17/22
Filed: 2015-09-08
Abstract: A support assembly for supporting fence panels includes a pair of spaced apart fence post receivers at a front end region of the support assembly. Each fence post receiver is dimensioned and configured to receive a leg of an end post of a fence panel. A base is fixed to the fence post receivers, wherein the base extends rearward with respect to the fence post receivers in an arrangement wherein the base is offset from the fence post receivers. At least one elongate locating member is one of arranged on and connectable to the base to extend upwardly from the base, the, or each, locating member being configured to be received in a respective opening defined by a weight that can be placed upon the base. The support assembly only projects on one side of a fence so as not to be a tripping hazard on the other side of the fence.
Patent NZ-728648-A (NZ)
Title: Multiple solid products liquid solution dispenser
Inventor: FREUDENBERG JARED R
IPC: A61L2/18
Filed: 2015-07-30
Abstract: A dispenser system for creating liquid solutions from either or both of a first solid product and a separate and distinct second solid product, where the liquid solutions comprise at least a first solution and a second solution. The system comprises an inlet portion configured to introduce the liquid into the dispenser system, a solution forming assembly comprising: a support structure 50 configured to support the first and second solid products; a reservoir 60 coupled to the support structure 50 , the reservoir 60 configured to hold the liquid and the first and second solutions and to allow the flow of the liquid into the reservoir 60 and the first and second solutions out of the reservoir. The reservoir 60 has a base from which a divider 69 extends out, the divider 69 forming a first reservoir portion and a second reservoir portion, the first reservoir portion comprising a first plurality of liquid inlets in the base 62b having a total first liquid inlet area, the second reservoir portion comprising a second plurality of liquid inlets 62a in the base having a total second liquid inlet area that is less than the total first liquid inlet area. The reservoir 60 is positioned proximate the support structure 50 such that the liquid confronts and dissolves the first solid product when the liquid is held in the first reservoir portion and such that the liquid confronts and dissolves the second solid product when the liquid is held in the second reservoir portion. The solution forming assembly is configured to form the first solution and the second solution, wherein the first solution and the second solution have different chemical compositions. There is an outlet portion configured to dispense the liquid solutions. The system facilitates the formation of solutions with differing concentration.
Patent NZ-734153-A (NZ)
Title: Human antibodies against tissue factor
Inventor: HOET RENE
IPC: C07K16/18
Filed: 2009-12-09
Abstract: Disclsoes human antibodies against tissue factor and cells expressing tissue gactor. Further discloses use for treating MDA-MB-231 tumors, inhibition of tissue factor induced blood coagulation and FVIIa binding. In preferred embodiments, the antibodies of the invention have a high affinity towards human tissue factor, mediate antibody-dependent cellular cytotoxicity (ADCC), inhibit FVIIa binding to TF, inhibit FVIIa-induced ERK phosphorylation and IL8 release.
Patent NZ-753209-A (NZ)
Title: Container for a tobacco related product
Inventor: NOVAK SLAVOMIR
IPC: A24F23/00
Filed: 2017-10-12
Abstract: The present invention relates to a container (100) for a tobacco related product (90), comprising a top portion (20) that is detachably connected to a base portion (10) and that comprises a cap (30) and a lid (40). The base portion (10) comprises a storage compartment (1 1 ) for storing the tobacco related product (90) and the cap (30) comprises a top wall (31 ) configured for fully covering the storage compartment (1 1 ). The lid (40) is swiveable about a axis of rotation (H1 ) that projects substantially perpendicular to the top wall (31 ) and is configured to close at least one additional compartment (32) that is arranged in the top wall (31 ) of the cap (30). Thus, the container (100) according to the present invention provides a storage compartment (1 1 ) for unused product and an additional compartment (32) for used product, wherein an erroneous access of the storage compartment (1 1 ) or the additional compartment (32), particularly a disposal of used product within the unused product, can be avoided.
Patent NZ-754730-A (NZ)
Title: Anti-icos agonist antibodies and uses thereof
Inventor: KORMAN ALAN J
IPC: C07K16/28
Filed: 2018-04-05
Abstract: The present invention provides isolated monoclonal antibodies (e.g., humanized and human monoclonal antibodies) that bind to human Inducible T Cell COStimulator (ICOS) and exhibit therapeutically desirable functional properties, e.g., the ability to stimulate human ICOS activity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells, and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules, and pharmaceutical compositions comprising the antibodies of the invention are also provided. The antibodies of the invention can be used, for example, as an agonist to stimulate or enhance an immune response in a subject, e.g., antigen- specific T cell responses against a tumor or viral antigen. The antibodies of the invention can also be used in combination with other antibodies (e.g., PD-1, PD-L1, and/or CTLA-4 antibodies) to treat, for example, cancer. Accordingly, the antibodies can be used in therapeutic applications and methods to detect ICOS protein.
Patent PT-102109-A (PT)
Title: Machine for manufacturing cod fish cakes and croquettes
IPC: B05C17/005
Filed: 1998-02-09
Abstract: The invention relates to the manufacture of cod fish cakes and croquettes. The process for manufacturing the two products is identical, using the same mechanisms and processes, with the exception of the mould and support tube. Thus, the paste is introduced into the injector 1 via the hopper, being transported to the exit die plate 2, and being forced to be more cohesive. The paste exits from the exit die plate, as appropriate: Cod fish cakes - it passes to the support tube 3 linking the exit die plate 2 and the cutting blade 4. The cutting blade constantly moves up and down and the paste passes by in a uniform manner and is cut into equal portions. The piece of dough passes to the mould 5 linked to an arm that moves in a lever system. The size of the mould determines the size of the fish cake. The mould is lubricated by a lubrication system. Lastly, the fish cake falls onto a rolling runner 6. Croquettes - the support is replaced by the exit tube 3 that can have a variety of measurements in keeping with the diameter of the croquette, and the mould for the cod fish cake is replaced by the croquette support base 5 that moves in a lever system. <IMAGE>
Patent PT-108928-A (PT)
Title: Placa tridimensionalmente configurável para múltiplas utilizações em construção, sua chapa matriz e seu processo de fabrico
Inventor: TOMÁS DE ALBUQUERQUE DA COSTA LIMA
IPC: E04F13/07
Filed: 2015-11-02
Abstract: PLACA (1) TRIDIMENSIONALMENTE CONFIGURÁVEL, PARA MÚLTIPLAS UTILIZAÇÕES EM CONSTRUÇÃO, A PLACA (1), POSSUINDO UMA DETERMINADA ESPESSURA E DEFININDO UM PLANO (P), COMPREENDE UMA PLURALIDADE DE SEGMENTOS (2) DE DOBRA ORIENTADOS NO REFERIDO PLANO (P) SEGUNDO PELO MENOS DUAS DIREÇÕES DISTINTAS, CADASEGMENTO (2) DE DOBRA POSSUINDO UMA DETERMINADA ALTURA; E FUROS (4) PASSANTES, ABERTOS EM ÁREAS DE CONVERGÊNCIA DE SEGMENTOS (2) DE DOBRA COM DIREÇÕES DIFERENTES; EM QUE A ESPESSURA DA PLACA CORRESPONDE À MAIOR ALTURA DOS SEGMENTOS (2) DE DOBRA. A INVENÇÃO REFERE-SE TAMBÉM A UMA CHAPA MATRIZ, QUE CONSTITUI A BASE DE FORMAÇÃO DA PLACA CONFIGURÁVEL E AO PROCESSO DE FABRICO DA ÚLTIMA. A PLACA CONFIGURÁVEL ABRANGE MÚLTIPLAS APLICAÇÕES, POR EXEMPLO COMO REVESTIMENTO INTERIOR OU EXTERIOR, OU COMO MOLDE PARA CONSTRUÇÃO DE EMBARCAÇÕES, PODENDO SER UTILIZADA PARTICULARMENTE NO CAMPO DA CONSTRUÇÃO, NOMEADAMENTE NA CONSTRUÇÃO CIVIL, NAVAL E AERONÁUTICA, MAS TAMBÉM NA INDÚSTRIA AUTOMÓVEL.
Patent RU-94017874-A (RU)
Inventor: KALJUGA V V
IPC: A01K7/00
Filed: 1994-05-13
Abstract: FIELD: agriculture, in particular, animal watering device. SUBSTANCE: animal nurser has casing and nipple imitating device positioned for longitudinal displacement within housing. Nipple imitating device has axial channel and radial openings, which are communicated one with another and made in nipple wall. Animal nurser is further provided with nipple stroke retainer formed as stop ring positioned in one slot made in inner surface of casing in the vicinity of nipple valve. Slot number and spacing are in accordance with number and spacing of radial openings in nipple wall. EFFECT: increased efficiency, simplified construction and enhanced reliability in operation. 2 cl, 2 dwg
Patent RU-94023282-A (RU)
Inventor: BERDNIK I V
IPC: C08F118/08
Filed: 1994-06-17
Abstract: FIELD: production of polymers. SUBSTANCE: method is carried out by polymerization in the presence of protective polymer colloid (its quantity being 5-15 mass parts) and emulsifying agent, their mass ratio being 2:1-1:4. 0.5 mass parts of initiator, 84-131 mass parts of water and 15 mass parts of peptizing agent are used per 100 mass parts of vinyl acetate. Said peptizing agent is added into reaction mixture before polymerization takes place. Sodium salt of copolymer of styrene with maleic anhydride in which 0.48-0.52 equivalents of carboxyl groups are neutralized by sodium hydroxide is used as mentioned above protective colloid. Bis(alkyl polyoxyethylene) phosphate is used as said emulsifying agent, dibutyl phthalate is used as said plasticizer and potassium persulfate being used as initiator. EFFECT: improves efficiency of the method. 1 tbl
Patent RU-94024623-A (RU)
Inventor: DEZHINOV B A
IPC: A61M1/10
Filed: 1994-07-01
Abstract: FIELD: medicine, as well as hydraulic systems with pulsating flow and amplitude oscillation process. SUBSTANCE: the offered device provides for creation of an artificial implanted organ of a human-being or animal-artificial hearth pump that can automatically change the rate of pulsation and its amplitude, coordinating these changes with the requirements of the human or animal organism, and prevent mechanical effect of the rotor on blood. A ball-type pump is known, which has a spherical detachable sealed body with ports and a rotor placed in it and formed by a disk and semi-disk hinge-joined to it; the disk divides the body into two hemispheres, one of which has the mentioned ports, and the semidisk divides it into working chambers. Innovation is in the fact that an annular groove is made in the body along the joint line of the hemispheres, the disk mounts the rotor for movement in it, and the hemisphere with ports is filled with working fluid, and its ports are in the same plane with the semi-disk and are fully overlapped by it in the position, in which it is perpendicular to the disk, and hermetically closed by a flexible or superflexible membrane; on the side of the other hemisphere in the central part of the hinge joint of the disk with the semi-disk provision is made for a recess with a rod installed perpendicularly to the longitudinal axis of the mentioned hinge joint and hinge-joined to the carrier, forming a mechanical coupling of the rotor with the rotor drive installed in this hemisphere and changing the angle of inclination of the semi-disk to the disk. EFFECT: improved design.
Patent RU-94032652-A (RU)
Inventor: TELJAKOV G V
IPC: C22C1/06
Filed: 1994-09-06
Abstract: FIELD: non-ferrous metallurgy, namely obtaining of aluminium alloys. SUBSTANCE: method of making aluminium alloy comprising introduction of charge and halogen-containing flux to melt metal comprises steps of using as melt metal aluminium and (or) its alloy, treating charge being introduced by halogen containing flux until achievement of density equal to 1.2-1.3 of liquid metal density, using as halogen-containing flux metal salts being components of alloy or their mixture with other halogen-containing components of flux; sustaining temperature of melt metal no less than by 50 C higher than flux melting temperature. EFFECT: enhanced quality of alloy. 3 cl
Patent RU-94037573-A (RU)
Inventor: SOLOV EV V M
IPC: F41B11/00
Filed: 1994-09-29
Abstract: FIELD: sporting weapon. SUBSTANCE: the invention makes it possible to convert pneumatic weapon and use it as a firearm for sporting and hunting purposes. To this end, the barrel is worked according to one of the offered variants: replacement of the firing spring, machining of the air piston, replacement of the barrel packing with a spring-loaded hammer pin, installation of an extractor on the barrel to extract small-caliber cartridges or empty cases. EFFECT: enhanced functional capabilities of pneumatic rifles and pistols.
Patent RU-94038385-A (RU)
Inventor: BASTRON A V
IPC: H02P13/00
Filed: 1994-10-11
Abstract: FIELD: power engineering. SUBSTANCE: control unit has shift register, shift shaper, ambient air temperature detectors, and disjunction unit; outputs of load-current measuring unit for arbitrary-demand load curve are connected to first inputs of disjunction unit whose second inputs are connected to ambient temperature detectors and outputs, to inputs of shift register and shift shaper whose output is connected to control input of shift register whose outputs are connected to inputs of switching device unit of loads of compulsory-demand curve. EFFECT: improved efficiency of power utilization by loads due to equalizing load curves of transformer substations and power lead-ins of loads.