baber/WOPTO huggingface dataset:
Patent AU-731909-B2 (AU)
Title: Compositions and methods for the delivery of oligonucleotides via the alimentary canal
Inventor: TENG CHING-LEOU
IPC: A61K48/00
Filed: 1998-07-01
Granted: 2001-04-05
Abstract: The present invention relates to compositions and methods which enhance the local and systemic uptake and delivery of oligonucleotides and nucleic acids via non-parenteral routes of administration. Pharmaceutical compositions comprising oligonucleotides disclosed herein include, for systemic delivery, emulsion and microemulsion formulations for a variety of applications and oral dosage formulations. It has also surprisingly been discovered that oligonucleotides may be locally delivered to colonic sites by rectal enemas and suppositories in simple solutions, e.g., neat or in saline. Such pharmaceutical compositions of oligonucleotides may further include one or more penetration enhancers for the transport of oligonucleotides and other nucleic acids across mucosal membranes. The compositions and methods of the invention are utilized to effect the oral, buccal, rectal or vaginal administration of an antisense oligonucleotide to an animal in order to modulate the expression of a gene in the animal for investigative, therapeutic, palliative or prophylactic purposes.
Patent AU-656343-B2 (AU)
Title: Method of ensuring that each node of a private telecommunication network is synchronized to the best at all available clock at all times and network
Inventor: CORDONNIER CHRISTINE
IPC: H04L7/00
Filed: 1991-12-10
Granted: 1995-02-02
Abstract: Each node (2) of the network is normally synchronised by clock signals of external origin which reach it through a point-to-point digital transmission connection input (3). Two of the nodal inputs (P1, P2) are preselected as main pilot clock and backup inputs and each node is preselected to be or not be a potential provider of clock signals in regard to each of the nodes to which it is connected, via one of its pilot clock inputs, the nodes thus connected of the private network determining a synchronising tree. In the event of the loss of a clock, an exchange of information is triggered between adjacent nodes in order to reconfigure the synchronising tree constituted by these nodes, in such a way that each of them is synchronised with the best available clock. <IMAGE>
Patent AU-650307-B2 (AU)
Title: Ball valve for fluids with seatings comprising laminated rings
Inventor: BONETTI GIULIO
IPC: F16K5/06
Filed: 1991-12-13
Granted: 1994-06-16
Abstract: Ball valve for fluids, with sealing seatings (14,15) comprising rings (16,17), disposed between the spherical surface of the valve and the interior of the valve body, composed of rings formed of superimposed layers (17) of plates of pure graphite alternating with plates (16) of stainless steel sheet, the whole being contained in a casing (18) of metal sheet covering the outer sides of the seating, except that in contact with the spherical sealing surface. <IMAGE>
Patent AU-731460-B2 (AU)
Title: Container comprising a pump
Inventor: KNEER ROLAND
IPC: B65D47/34
Filed: 1998-08-21
Granted: 2001-03-29
Abstract: A mainly tubular insert (3) is fitted into the opening (2) of the container (1). The insert has a sealed base (5), which defines a holder chamber (15) for e.g. liquid pharmaceuticals. The front end section of the pump projects into the insert, with the end section wall engaging tightly on the wall of the insert. Before first use, the pump unit is moved forward in axial container direction and the end section opens the insert base.
Patent DE-1909565-B2 (DE)
Title: Colour tube convergence correction coil - has superimposed AC and DC currents adjusted by resistance network and differential amplifier
IPC: H04N9/28
Filed: 1969-02-26
Abstract: A static and dynamic convergence correction system is for colour television tubes. A correction coil for each beam on a magnetic core on the tube neck carries correcting currents at line and frame frequencies; each coil is connected between the output terminals of a differential amplifier with two amplifier units to the inputs of which the dynamic correction signals are applied through a resistance network; the bias voltages for the amplifiers are derived from a potentiometer with earthed tap forming part of a second resistance network connected between the third electrodes of the amplifiers. The superimposed AC and DC currents through the correction coil are varied by adjustments to the resistance networks.
Patent DE-1921486-B2 (DE)
Title: Programmed system for automatic titration - has valve arrangement on measurement chamber which allows rapid purging with purge liquor
IPC: G01N31/16
Filed: 1969-04-26
Abstract: Titrations are carried out by automatic programmed system using a measurement chamber with photo-electric control. It has a metering system for indicator, buffer soln. and the titration liquid. A measured sample of liq. under test is injected from a calibrated measurement chamber. It has a control system whereby the metering of reagents is controlled by the reaction of the test sample. Provision is made for emptying and flushing out the measurement chamber at the end of each cycle. The measuring chamber at the end of each cycle. The measuring vessel has an overflow, a filling valve and an outlet valve. While the sample is run off, the filling valve remains closed. When the chamber is being flushed, both valves are open. Used for monitoring total water hardness, carbonate hardness in breweries, lemonade factories, heating and cooling water plants, etc. for monitory alkali strength for bottle washing, laundries, textile and paper mills, for acid monitoring in effluents, etc. Allows a much more rapid cycle than conventional titrimeters while retaining true discontinuous measurement and adequate flushing.
Patent DE-1929672-B2 (DE)
Title: Oscillation bandpass filter of conductive elements - has sections of higher and lower wave resistance of different characteristics
IPC: H01P1/205
Filed: 1969-06-11
Abstract: The conductive sections of higher wave resistance are in the form of short circuited lines, while those of lower wave resistance are in the form of idle lines. Two metal plates which are parallel to the insulating carrier plate, are coupled by a metal strip which short circuits the conductive sections of higher wave resistance. A continuous metal coating is provided on the carrier plate side opposite the conductors of lower wave resistance. This coating is connected with a strip of electrically conductive material which simultaneously conductively connects the two metal plates. Preferably the carrier plate is of material whose dielectric constant is considerably higher than that of air.
Patent DE-1955697-B2 (DE)
Title: Sync. machine brushless excitation system - has identical anti-parallel windings with yoke rings between and at end
IPC: H01F38/18
Filed: 1969-11-01
Abstract: The brushless excitation system for a synchronous machine consists of a single coil system or multiple coil arrangement, with two anti-parallel sets of magnetically interacting windings (11, 12, 21, 22) of the same dia., number of coils, and cross-sectional area of conductors. Each has a yoke ring positioned coaxially between them for conveying the magnetic flux between them. The part winding (12 or 22) directly alongside each other axially, of two transmission systems are wound on the same coil body (14). Each has a further yoke ring (4) at the end.
Patent DE-2222987-B2 (DE)
Title: VHF transmitter in rectangular case - has layout permitting alignment of primary radiator and reflector with min. feed losses
IPC: H04B1/3827
Filed: 1972-05-10
Abstract: A rectangular case for a transmitter or receiver for very high frequency directional communications is formed of two parts (22, 23). The case (1) is divided along the diagonals (19) of the opposite long side, with a flange (14, 3) to which an aerial reflector (2) can be fitted. It has a primary radiator, especially a horn, as in 2208106. The primary radiator (1) with all other radio frequency units, are arranged on a metal bracket component (2) of which the lower face (6) fits the machined base (4) of the case. The radio frequency components are so arranged that a double bent U-shaped connector is formed between the input of the horn radiator (1) and the components (10) on the bracket face (6).
Patent DE-2235919-B2 (DE)
Title: Broken cheese transfer machine - with automatic level control of pipe conveyor transfer point by filler funnel float
IPC: B65G53/06
Filed: 1972-07-21
Abstract: A broken cheese transfer machine from a tank to a proportioning device includes an endlesss belt conveyor which is charged through a pipe by the pressure of the broken cheese column in a storage tank. The transfer point between pipe and conveyor is automatically adjusted in elevation as a function of the level in a filler tunnel. This achieves a very steady flow rate independent of the matl. level in the broken en cheese storage tank. The remaining slight fluctuations are negligible.
Patent JP-H022620-B2 (JP)
IPC: B03D1/14
Filed: 1982-01-29
Abstract: An improved method and apparatus for froth flotation separation of the components of a slurry, having particular utility for the beneficiation of coal by the flotation separation of coal particles from impurities associated therewith such as ash and sulfur. In this arrangement, a spray nozzle is positioned above a flotation tank having a water bath therein, and sprays an input slurry through an aeration zone into the surface of the water. The spraying operation creates a froth on the water surface in which a substantial quantity of particulate matter is floating, while other components of the slurry sink into the water bath. A skimming arrangement skims the froth from the water surface as a cleaned or beneficiated product.
Patent JP-S5724258-B2 (JP)
IPC: B60Q1/076
Filed: 1979-02-13
Abstract: A motorized headlamp position adjusting circuit for adjusting the angular position of a vehicular headlamp includes two motor position switches and an operating switch interconnected such that the number of wires to the control switch is reduced.
Patent JP-H0428104-B2 (JP)
IPC: H04N1/06
Filed: 1981-03-16
Abstract: A light beam projecting system comprising a light source and a condenser lens system is mounted on a rotator to project radially outwardly a light beam modulated by a desired modulating signal representing information to be recorded while rotating together with the rotator. The rotator is mounted for movement in the direction parallel to the rotational axis thereof whereby the light beam emitted from the light beam projecting system is caused to scan a recording medium opposed to the peripheral surface of the rotator to record the information thereon.
Patent JP-H0617216-B2 (JP)
IPC: C01B39/02
Filed: 1986-03-13
Abstract: The present invention relates to a novel crystalline massive aluminosilicate with an expanded structure and to its process of manufacture. The particular structure is a closed cell structure containing nitrogen. It is obtained by: grinding industrial glass; adding aluminum based nitride in the proportion of 0.1 to 20% by weight with respect to the weight of the ground industrial glass; mixing the ground glass and so-added nitride; oxidizing the nitride within said mixture by heating to a temperature of 800 DEG  to 1000 DEG  C. for about 1 hour, and cooling and recovering the expanded crystalline aluminosilicate. The material has multiple applications in the building industry and in the construction of furnaces, in the manufacture of fireproof walls and doors, and in naval construction, with various advantages over prior art materials.
Patent JP-2888906-B2 (JP)
IPC: A23L2/06
Filed: 1990-03-07
Granted: 1999-05-10
Abstract: Method of and apparatus for extracting whole juice sacs from citrus fruits by fluid impinging chunks of peeled fruit meat. In one embodiment, a fruit chunk (20) is fed into a fluid impingement chamber (10) that includes a plurality of off-center orifices (13, 14). High-pressure fluid emitted from the orifices strikes the fruit chunk and spins it such that the fruit chunk's juice sacs are stripped from the chunk's sectional membranes. In another preferred embodiment, a plurality of fluid impingement chambers (10) are incorporated into a high-speed, continuous motion turret. In yet another preferred embodiment, fruit chunks are fed into an inclined tube that includes fluid orifices which emit high pressure fluid. Controlling the fluid pressure, nozzle orifice size, number of orifices, direction of fluid jets, impingement time, and size and shape of the fruit chunks determine how substantially the radial membranes of fruit chunks are stripped of juice sacs without shredding the membranes. By avoiding contamination by or commingling with flavor-deteriorating membranes or peel components of fruits, the resulting juice and juice sac slurry has a taste more like fresh-squeezed juice after further processing and storage than current commercially-made juice.
Patent JP-3562016-B2 (JP)
IPC: F02B27/00
Filed: 1995-03-17
Granted: 2004-09-08
Abstract: A lean burn engine adapted to establish a specified air-fuel ratio leaner by predetermined rate than a stoichiometric air-fuel ratio in a range of low engine speeds and low engine loads is provided with an air intake system of a low speed type which provides a high charging efficiency in a range of low engine speeds and an exhaust system capable of eliminating a nitrogen oxide emission in the exhaust even during lean burning. <MATH>
Patent JP-H0365350-B2 (JP)
IPC: C07D501/46
Filed: 1984-03-30
Abstract: Compounds of the formulawherein R' is hydrogen or a conventional amino-protecting group, R<sup>2</sup> is a straight or branched chain alkyl, alkenyl or alkynyl containing from 1 to 4 carbon atoms, andis a quaternary ammonio group as described herein, and nontoxic pharmaceutically acceptable salts, physiologically hydrolyzable esters and solvates thereof, as well as processes for their preparation, are disclosed. The compounds in which R' is hydrogen are potent antibacterial agents.
Patent JP-H0761416-B2 (JP)
IPC: B01J20/02
Filed: 1988-03-23
Abstract: A process for drying a gaseous hydrogen halide of the formula HX, wherein X is selected from the group consisting of bromine, chlorine, fluorine, an iodine, to remove water impurity therefrom, comprising: contacting the water impurity-containing gaseous hydrogen halide with a scavenger including a support having associated therewith one or more members of the group consisting of:   (a) an active scavenging moiety selected form one or more members of the group consisting of: (i) metal halide compounds dispersed in the support, of the forumla MXy; and (ii) metal halide pendant functional groups of the formula -MXy-1 covalently bonded to the support, wherein M is a y-valent metal, and y is an integer whose value is from 1 to 3; (b) corresponding partially or fully alkylated compounds and/or pendant functional groups, of the metal halide compounds and/or pendant functional groups of (a); wherein the alkylated compounds and/or pendant functional groups, when present, are reactive with the gaseous hydrogen halide to form the corresponding halide compounds and/or pendant functional groups of (a); and M being selected such that the heat of formation,  DELTA Hf of its hydrated halide, MXy . (H2O)n, is governed by the relationship:       DELTA Hf>/= n x 10.1 kilocalories/mole      of such hydrated halide compound wherein n is the number of water molecules bound to the metal halide in the metal halide hydrate. Also disclosed is an appertaining scavenger composition and a contacting apparatus wherein the scavenger is deployed in a bed for contacting with the water impurity-containing gaseous hydrogen halide.
Patent JP-3299805-B2 (JP)
IPC: B22F3/02
Filed: 1993-03-08
Granted: 2002-07-08
Abstract: An improved metallurgical powder composition comprising an iron-based powder and an alloying powder is provided. The composition contains a polyalkylene oxide having a number average molecular weight of at least about 7,000 as a binder. The binder of this invention permits the bonded powder composition to achieve compressibility equivalent to that of unbonded compositions and maintains resistance to dusting and segregation of the alloying powder.
Patent JP-H0824594-B2 (JP)
IPC: C12P21/00
Filed: 1991-04-12
Abstract: Method for activating non-glycosylated tissue plasminogen activator (t-PA) after its expression in prokaryotic cells comprises cell lysis; solubilisation under denaturing and reducing conditions, and reactivation under oxidising conditions in presence of reduced and oxidised glutathione (G5H, G55G). The new feature is that in the last stage is at pH 9-12 (pref. 9.5-11) with G5H and G55G concns. 0.1-20, pref. 0.2-10, mM and 0.01-3, pref. 0.5-1, mM, respectively, and with a non-denaturing concn. of the denaturing agent. Esp. the method is applied to t-PA expressed in E.coli and P. putida. The denaturing agent is pref. arginine, guanidine hydrochloride (both at 0.1-1, esp. 0.25-0.75, mM) or urea, at 0.5-4 (esp. 1-3.5) M in the last stage.
Patent JP-3712561-B2 (JP)
IPC: G02B1/14
Filed: 1999-03-30
Granted: 2005-11-02
Abstract: The invention provides a cured film-coated optical element having good scratch resistance, good moisture resistance and good weather resistance, of which the properties are degraded little even when it is further coated with a deposit film of an inorganic oxide. Provided is an optical element having, on an optical substrate, a cured film formed of a coating agent that contains (A) modified stannic oxide-zirconium oxide composite colloid particles as prepared by coating at least a part of the surfaces of stannic oxide-zirconium oxide composite colloid particles with stannic oxide-tungsten oxide-silicon oxide composite colloid particles, and (B) an organosilicon compound.
Patent JP-S6236516-B2 (JP)
IPC: A01N43/84
Filed: 1979-08-07
Abstract: The invention relates to an improved process for the preparation of fungicidally active compounds of the formula   <IMAGE>   wherein R1 and R2 individually are lower alkyl of from 1 to 4 carbons or halo-(lower alkyl) of from 1 to 4 carbons or R1 and R2 together with the carbon to which they are attached form a 3 to 7 membered cycloalkyl ring or lower alkyl-substituted cycloalkyl of from 4 to 9 carbons, R3, R4 and R5 individually are hydrogen or lower alkyl of from 1 to 4 carbons and X is methylene or oxygen, and salts of those compounds which are basic. The improved process comprises the reaction of a compound of the formula,   <IMAGE>  wherein R3, R4, R5 and X have the significance given hereinabove, with a compound which forms a carbonium ion of the formula   <IMAGE>  wherein R1 and R2 have the significance as given hereinabove.
Patent EP-1054064-B2 (EP)
Inventor: BOUT ABRAHAM
IPC: A61K39/00
Filed: 2000-05-16
Granted: 2009-12-16
Abstract: The adenovirus serotypes differ in their natural tropism. The adenovirus serotypes 2, 4, 5 and 7 all have a natural affiliation towards lung epithelia and other respiratory tissues. In contrast, serotypes 40 and 41 have a natural affiliation towards the gastrointestinal tract. The serotypes described above, differ in at least capsid proteins (penton-base, hexon), proteins responsible for cell binding (fiber protein), and proteins involved in adenovirus replication.  This difference in tropism and capsid protein among serotypes has led to the many research efforts aimed at redirecting the adenovirus tropism by modification of the capsid proteins.
Patent EP-0290088-B2 (EP)
Inventor: MILES RICHARD
IPC: C10L1/14
Filed: 1988-04-27
Granted: 1995-11-29
Abstract: Improved gasoline compositions containing a minor amount of a polyalphaolefin having a viscosity at 100 DEG C from 2 to 20 centistokes, and optionally also an aliphatic polyamine, an alkali or alkaline earth metal salt of a succinic acid derivative, and/or a polyolefin; together with a concentrate for the production of such gasoline composition and a method of operating a spark-ignition engine using such gasoline composition.
Patent EP-0545942-B2 (EP)
Inventor: BIVENS DONALD BERNARD
IPC: C09K5/04
Filed: 1991-06-17
Granted: 2003-12-10
Abstract: Mélanges pratiquement azéotropes de: (a) pentafluoroéthane et de 1,1,1-trifluoroéthane avec un ou plusieurs composés parmi: chlorodifluorométhane, 1,2,2,2-tétrafluoroéthane, 1,1,2,2-tétrafluoroéthane, 1-chloro-1,1,2,2-tétrafluoroéthane, 1-chloro-1,2,2,2-tétrafluoroéthane, 1,1,1,2,3,3,3-heptafluoropropane, 1,1,1,2,2,3,3-heptafluoropropane, et perfluorocyclopropane; (b) de chlorodifluorométhane et de pentafluoroéthane avec un ou plusieurs composés parmi: éthane, butane, isobutane, éther de diméthyle, propylène, et difluorométhane; (c) de chlorodifluorométhane avec du 1,1,1-trifluoroéthane et du 1,2,2,2-tétrafluoroéthane, du propane et du pentafluoroéthane, ou du 1,1,1-trifluoroéthane et de l'octafluoropropane; (d) et de pentafluoroéthane avec du fluoroéthane et du 1,2,2,2-tétrafluoroéthane. L'invention concerne également l'utilisation de ces mélanges en tant que réfrigérants.
Patent EP-0789742-B2 (EP)
Inventor: WILSCH-IRRGANG ANNELIESE
IPC: C09K23/42
Filed: 1995-10-27
Granted: 2010-04-14
Abstract: PCT No. PCT/EP95/04224 Sec. 371 Date May 5, 1997 Sec. 102(e) Date May 5, 1997 PCT Filed Oct. 27, 1995 PCT Pub. No. WO96/14375 PCT Pub. Date May 17, 1996An aqueous composition for the post-treatment of washed laundry containing 0.1 to 30% by weight of a water-insoluble quaternary ammonium compound, 0.1 to 50% by weight of a water-soluble quaternary ammonium compound, 0 to 5% by weight of a terpene compound, 0.1 to 20% by weight of a water-soluble acid, and 0.1 to 20% by weight of an emulsifier.
Patent EP-0865271-B2 (EP)
Title: Use of 2-ethylhexyl alpha-cyano-beta,beta-diphenylacrylate in order to improve the photostability of p-methylbenzylidene camphor
Inventor: HANSENNE ISABELLE
IPC: A61K8/40
Filed: 1996-12-05
Granted: 2004-03-17
Abstract: PCT No. PCT/FR96/01945 Sec. 371 Date Aug. 24, 1998 Sec. 102(e) Date Aug. 24, 1998 PCT Filed Dec. 5, 1996 PCT Pub. No. WO97/21422 PCT Pub. Date Jun. 19, 1997The present invention relates to the use of 2-ethylhexyl  alpha -cyano- beta , beta -diphenylacrylate in, or for the manufacture of, cosmetic compositions containing p-methylbenzylidenecamphor in combination with at least one dibenzoylmethane derivative, for the purpose of improving the stability of p-methylbenzylidenecamphor in such compositions.
Patent EP-0898606-B2 (EP)
Inventor: CONNOR DANIEL STEDMAN
IPC: C09K23/42
Filed: 1997-04-16
Granted: 2010-10-06
Abstract: Tensioactifs de sulfate alcoxylé d'alkyle primaire ramifié en milieu de chaîne, utiles dans les compositions de lessive et de nettoyage, en particulier dans celles qui se présentent sous une forme liquide ou granulée. Ces mélanges tensioactifs sont également adaptés à des formulations comprenant d'autres tensioactifs, pour la production de systèmes tensioactifs améliorés, particulièrement pour les compositions détergentes prévues pour les lessives effectuées dans une eau à basse température. L'invention se rapporte également à de nouveaux tensioactifs de sulfate alcoxylé d'alkyle primaire ramifié en milieu de chaîne adaptés aux mélanges tensioactifs.
Patent EP-1015410-B2 (EP)
Title: Verfahren zur herstellung von acrylsäure und methacrylsäure
Inventor: ECK BERND
IPC: C07C51/44
Filed: 1998-09-09
Granted: 2007-09-26
Abstract: Verfahren zur Herstellung von Acrylsäure oder Methacrylsäure durch Herstellung eines gasförmigen Produktgemischs, das im wesentlichen die Zusammensetzung eines Reaktionsgemischs der katalytischen Gasphasenoxidation von C3-/C4-Alkanen, -Alkenen, -Alkanolen oder -Alkanalen oder Vorstufen davon zu Acrylsäure bzw. Methacrylsäure hat. Die Abtrennung des Produktes aus dem gasförmigen Produktgemisch erfolgt dabei nach einem Verfahren, das folgende Schritte enthält: (a) Kondensation des gasförmigen Produktgemischs, (b) Kristallisation der Acrylsäure oder Methacrylsäure aus der in Stufe (a) erhaltenen Lösung, (c) Abtrennung der erhaltenen Kristalle aus der Mutterlauge und (d) Rückführung wenigstens eines Teils der Mutterlauge aus Stufe (c) in Stufe (a).