baber/WOPTO huggingface dataset:
Patent EP-3374504-A2 (EP)
Inventor: BAUMHOF PATRICK
IPC: C12N15/00
Filed: 2016-11-09
Abstract: La présente invention concerne des molécules d'acide nucléique optimisées, des procédés d'optimisation de molécules d'acide nucléique et des utilisations de molécules d'acide nucléique optimisées. L'invention concerne un principe de construction modulaire permettant de générer un acide nucléique, notamment un ARN messager, qui est conçu pour une application donnée. Les molécules d'acide nucléique selon la présente invention peuvent être obtenues par la combinaison polyvalente de multiples modules au niveau de l'acide nucléique. Un tel acide nucléique, par exemple un ARNm, peut être conçu en associant un ou plusieurs modules, comprenant (i) une fraction d'acide nucléique codant un polypeptide d'intérêt (par exemple une protéine produisant éventuellement un résultat thérapeutique) et (ii) au moins une autre fraction d'acide nucléique codant ou non codant, par exemple une fraction choisie parmi des fractions d'acide nucléique codant un élément polypeptidique, par exemple un peptide signal de sécrétion (SSP), un élément de multimérisation (dimérisation, trimérisation, tétramérisation et oligomérisation), un élément formant une particule du type viral (VLP), un élément transmembranaire, un élément ciblant les cellules dendritiques, un élément adjuvant immunologique, un élément favorisant la présentation de l'antigène ; un peptide 2A ; un élément de liaison peptidique, des éléments qui prolongent la demi-vie de protéines et/ou toute autre polypeptide ou protéine. Des fragments d'acide nucléique non codant peuvent être choisis par exemple dans le groupe comprenant 3'-UTR, 5'-UTR, l'élément IRES, le fragment ARNmi, une boucle histone, une séquence poly(C), un signal de polyadénylation, une séquence poly(A). La molécule d'acide nucléique optimisée peut en outre être caractérisée par la présence d'au moins un nucléoside modifié. La polyvalence de la présente invention permet la conception rationnelle d'une grande variété de molécules d'acide nucléique différentes ayant des propriétés souhaitées.
Patent EP-3363527-A2 (EP)
Inventor: METZLER RICHARD
IPC: B01D71/02
Filed: 2017-12-07
Abstract: Die vorliegende Erfindung zeigt ein Verfahren zum Betrieb einer Filtrationsanlage mit einem Behälter, in welchen die zu filtrierende Flüssigkeit einströmt und/oder aus welchem das Retentat abströmt, und mit Filtrationsscheiben, welche in dem Behälter auf einer drehbaren Welle angeordnet sind, wobei die Filtrationsscheiben jeweils einen Grundkörper, eine auf den Außenseiten des Grundkörpers angeordnete keramische Membran und eine Axialbohrung aufweisen, wobei die Axialbohrungen den Permeat-Abfluss der Filtrationsscheiben bilden und mit einem in der Welle angeordneten Abflusskanal in Verbindung stehen. Dabei ist vorgesehen, dass abwechselnd eine Filtration und eine Begasung der zu filtrierenden Flüssigkeit erfolgt, wobei bei der Filtration das Permeat aus den Filtrationsscheiben über die Welle abfließt und bei der Begasung Gas über die Welle und die Filtrationsscheiben in die zu filtrierende Flüssigkeit eingebracht wird.
Patent EP-3559358-A2 (EP)
Title: A cleaning equipment
Inventor: SSIMSIR BOGAÇ
IPC: E03C1/04
Filed: 2017-12-13
Abstract: The cleaning equipment (A) developed comprises the body (A1) through which the water may pass; the water outlet (A2) where the water passing through the body (A1) is delivered to the user; the sensor (A3), which detects the presence of an object; the automatic flow mode in which the flow of water is enabled upon the sensor (A3) detecting the presence of the object; the manual flow mode in which the flow of water is controlled only by the contact of the user; the mixed flow mode in which the flow of water is able to be controlled both by the user's contact and in a non-contact manner; the first adjustment member (A4), which enables, via rotational motion about an axis, the adjustment of the temperature of the water to be delivered to the user via the water outlet (A2); the second adjustment member (A5), which enables, via rotational motion about an axis, the adjustment of the flow rate of the water to be delivered to the user via the water outlet (A2) in all the flow modes; the control unit (K), which determines the extent of rotation of the adjustment members and accordingly enables the adjustment of the temperature and the flow rate for the water to be delivered to the user; and the switch (B), which is connected to the control unit (K), is able to be triggered mechanically or in a touch-operated manner by means of the first adjustment member (A4) and/or the second adjustment member (A5) and enables, upon being triggered, the switching to be performed between the flow modes or the flow of water to be controlled in the manual flow mode.
Patent EP-3403841-A2 (EP)
Inventor: IIDA KENICHI
IPC: B41M5/00
Filed: 2018-05-02
Abstract: An inkjet printing method including the steps of applying a first ink to a printing medium (32) and applying a second ink to the printing medium (32) so as to at least overlap a region provided with the first ink, wherein the first ink is an aqueous ink containing silver particles, the second ink is an aqueous ink containing an anionic dye, the printing medium (32) includes an ink-receiving layer containing at least one cationic compound selected from a group consisting of a polyvalent metal salt and a salt of a cationic resin, and the content (g/m 2 ) of the cationic compound per unit area of the ink-receiving layer (32) is 0.20 g/m 2  or more.
Patent EP-3610002-A2 (EP)
Inventor: MATSUZAKI YUKA
IPC: C12N5/0793
Filed: 2018-04-11
Abstract: A method of altering cells comprising culturing them in a growth factor gradient, wherein said gradient is provided by a polyhedra delivery system (PODS) that releases the growth factor to set up the gradient.
Patent EP-3517607-A2 (EP)
Inventor: KIM HYUNG JOON
IPC: C12P13/02
Filed: 2018-06-29
Abstract: The present disclosure relates to an aspartokinase variant, a microorganism comprising the variant, and a method for producing an aspartate-derived L-amino acid or a homoserine derivative thereof by using the microorganism.
Patent EP-3729488-A2 (EP)
Inventor: BAJIC STEVAN
IPC: H01J49/04
Filed: 2018-12-21
Abstract: A method of ionizing a sample is disclosed that comprises heating a sample so that analyte is released from the sample, producing charged particles such as charged droplets downstream of the sample, and using the charged particles to ionize at least some of the analyte released from the sample so as to produce analyte ions.
Patent EP-3647417-A2 (EP)
Inventor: PARK MYUNG KEUN
IPC: C12N9/10
Filed: 2018-08-02
Abstract: The present disclosure relates to an ATP phosphoribosyltransferase (HisG) protein and a method for producing histidine using the same.
Patent EP-3827030-A2 (EP)
Title: Hydrogenation of nitrile rubber
Inventor: LIU QINGCHUN
IPC: C08C19/02
Filed: 2019-07-09
Abstract: This invention relates to a novel process for selectively and efficiently hydrogenating nitrile rubber in the presence of specific complex catalysts system comprising an NHC-ligand comprising Ru-complex catalyst and a specific hydrogenation enhancer.
Patent EP-3834122-A2 (EP)
Inventor: GUPTA ASHISH
IPC: G06F113/10
Filed: 2019-09-05
Abstract: Methods and systems are disclosed for a computer aided design system for designing multilevel lattice structures. A coarse lattice module defines a coarse lattice of balls connected by beams within a first boundary. A fine lattice module defines a fine lattice of balls connected by beams within a second boundary. The coarse lattice and the fine lattice have intersecting regions. A trimming module constructs a multilevel lattice structure according to a trimming operation based on the intersecting regions.
Patent EP-3820384-A2 (EP)
Inventor: BAEZ LUIS ANDRADE JR
IPC: A61B17/295
Filed: 2019-08-22
Abstract: Certains aspects concernent des instruments médicaux pouvant être commandés de façon manuelle et robotique. Un instrument médical pouvant être commandé de façon manuelle et robotique peut comprendre une tige allongée pouvant être articulée par des fils de traction. La tige allongée peut être reliée à une poignée d'instrument qui se fixe à un mécanisme d'entraînement d'instrument. La poignée d'instrument peut comprendre un ensemble poulie sur lequel peuvent être montés les fils de traction. La rotation de l'ensemble poulie peut actionner les fils de traction afin de provoquer l'articulation de la tige allongée. L'instrument médical comprend également une entrée d'entraînement manuel reliée à l'ensemble poulie de telle sorte que l'actionnement manuel de l'entrée d'entraînement manuel provoque la rotation du premier ensemble poulie et une entrée d'entraînement robotique conçue pour entrer en prise avec une sortie d'entraînement robotique du mécanisme d'entraînement d'instrument de telle sorte que la rotation de la première sortie d'entraînement robotique provoque la rotation de l'ensemble poulie.
Patent EP-3702156-A2 (EP)
Title: Verfahren zur herstellung einer wasserdampfdurchlässigen flächigen verbundfolie
Inventor: BACHON THOMAS
IPC: B32B37/15
Filed: 2020-01-22
Abstract: Die Erfindung betrifft ein Verfahren zur Herstellung einer wasserdampfdurchlässigen flächigen Verbundfolie (1), wobei eine Klebstoffschicht (2) mittels einer Düsenanordnung (3) auf eine Trägerschicht (4) aufgetragen wird und eine, vorzugsweise monolithische, Funktionsschicht (5), insbesondere auf die Klebstoffschicht, (2) extrudiert wird. Erfindungsgemäß ist vorgesehen, dass die Klebstoffschicht (2) mittels einer Mehrzahl von in Längsrichtung (L) der Trägerschicht (4) verlaufenden Längsstreifen (6) von der Düsenanordnung (3) aufgebracht wird, wobei benachbarte Längsstreifen (6) voneinander beabstandet sind.
Patent EP-3858347-A2 (EP)
Inventor: LOW PHILIP STEWARD
IPC: A61P43/00
Filed: 2008-08-15
Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
Patent EP-3966848-A2 (EP)
Inventor: PUGLISI ROSARIA ANNA
IPC: H01L21/225
Filed: 2020-05-08
Abstract: Method of doping a semiconductor sample in a uniform and carbon-free way, wherein said sample has a surface, comprising the following steps: A. removing oxides from at least part of the said surface; B. dip coating said at least part of the surface of the sample in a dopant based carbon-free solution of at least one dopant based carbon free substance diluted in water, wherein said at least one dopant based carbon free substance has a molecule comprising at least one dopant atom, wherein the dip coating is achieved by heating said dopant based carbon-free solution at a dip coating temperature from 65% to 100% of the boiling temperature of said dopant based carbon-free solution, thereby a self-assembled mono-layer including dopant atoms is formed; C. annealing said sample, wherein the annealing is configured to cause said dopant atoms included in said self-assembled mono-layer to be diffused into the sample.
Patent EP-3961662-A2 (EP)
Inventor: RAMABHADRAN RAMANUJAM
IPC: H01F3/00
Filed: 2021-06-18
Abstract: A component (100) includes a magnetic core (120) having a body (125) formed of a first material (141), defining a first opening (121) and a second opening (122) thereon. A duct (140) formed of a second material (142) extends at least partially through the body (125) between the first opening (121) and the second opening (122). The first opening (121) and the second opening (122) are in fluid communication by way of the duct (140).
Patent EP-4121394-A2 (EP)
Inventor: CUI YI
IPC: C01D15/00
Filed: 2021-03-16
Abstract: Electrochemical methods using intercalation chemistry to extract Li from seawater using the TiO2-coated FePO4 electrode. The difference in the thermodynamic intercalation potentials, as well as the diffusion barriers between Li and Na, could provide near 100% selectivity towards Li interaction when Li/Na molar ratio is higher than 10-3. For lower Li/Na ratio as in the authentic seawater case, pulsed-rest and pulse-rest-reverse pulse-rest electrochemical methods were developed to lower the intercalation overpotential and it was proven to successfully boost the Li selectivity. Moreover, the pulse-rest-reverse pulse-rest method can also promote electrode crystal structure stability during the co-intercalation of Li and Na and prolong the lifetime of the electrode. Finally, 10 cycles of successful and stable Li extraction with 1:1 of Li to Na recovery from authentic seawater were demonstrated, which is equivalent to the selectivity of ~1.8104. Also, with lake water of higher initial Li/Na ratio of 1.6 10-3, Li extraction with more than 50:1 of Li to Na recovery was achieved.
Patent EP-4251109-A2 (EP)
Title: Ohrkatheter und einführhilfe für katheter
Inventor: SUDHOFF HOLGER
IPC: A61F11/20
Filed: 2021-11-25
Abstract: Die Erfindung betrifft einen Ohrkatheter zur Einführung in die Ohrtrompete mit einem ersten Schlauch als Katheterschlauch (3) mit mindestens einem ersten Lumen als Injektionskanal (3A) zur Applikation einer Flüssigkeit, mindestens einem zweiten Lumen als Druckentlastungslumen (3B) zur Druckentlastung und einem selbstexpandierbaren Dichtelement (2) zum Verschluss der Ohrtrompete sowie eine Einführhilfe mit einem Kopfstück, einem Mittelstück und einem Endstück, wobei die Einführhilfe aus einem körperverträglichen Polymer besteht und zumindest durch das Mittelstück und das Endstück jeweils mindestens eine Trennlinie verläuft, entlang derer die Einführhilfe aufgeklappt oder aufgespalten werden kann. Die erfindungsgemäße Einführhilfe kann somit von einem Katheter entfernt werden, auch wenn die Katheterenden blockiert sind.
Patent EP-4050418-A2 (EP)
Inventor: TAKAHASHI KOJI
IPC: G03G5/10
Filed: 2022-02-21
Abstract: An electrophotographic photosensitive member having: a support with a cylindrical shape; and a photosensitive layer, in which the support has a surface formed of Al and/or an Al alloy, and the surface of the support includes Al crystal grains having (α) plane having {001} orientation of -15° or more and less than +15°, (β) plane having {101} orientation of -15° or more and less than +15°, and (γ) plane having {111} orientation of-15° or more and less than +15°, a ratio of an area occupied by Al crystal grains having (γ) to the total area of the surface of the support is 10% or less, and a ratio of an area occupied by any one of Al crystal grains having (α) and Al crystal grains having (β) is 60% or more.
Patent EP-4057321-A2 (EP)
Title: Optimizing mass spectra signal quality by adjusting a position of an ionization emitter relative to an inlet of a mass spectrometer
Inventor: KALAFUT BENNETT S
IPC: H01J49/00
Filed: 2022-03-09
Abstract: An optimization control system may receive mass spectra of ions emitted from an ionization emitter toward an inlet of a mass spectrometer and control, based on the mass spectra, an automated motion system to adjust a position of the emitter relative to the inlet.
Patent EP-4102687-A2 (EP)
Title: Overmolded rotor structure
Inventor: ZHENG TONG
IPC: H02K9/06
Filed: 2022-06-06
Abstract: A brushless direct-current (BLDC) motor is provided. The motor includes a stator including a stator core, stator teeth, and windings; a rotor shaft disposed within the stator and extending along a longitudinal axis; and a rotor (504). The rotor includes a rotor core (508) including an inner body mounted on the rotor shaft and radial projections projecting outwardly from the inner body (512), a permanent magnet mounted on an outer end of the radial projections, and a mold structure (510) formed in contact with the radial projections (514) and configured to secure the permanent magnet to the rotor core.
Patent EP-4235552-A2 (EP)
Inventor: WRIGHT CRAIG STEVEN
IPC: G06Q20/40
Filed: 2017-02-16
Abstract: The invention provides a secure method for exchanging entities via a blockchain. The invention incorporates tokenisation techniques, and also techniques for embedding metadata in a redeem script of a blockchain transaction. Embodiment(s) provide a computer implemented method of performing a transfer, the method comprising: generating a first exchange transaction, and broadcasting, over a first network, the first exchange transaction for inclusion on a P2P distributed ledger, wherein the first exchange transaction comprises: an indication of a first quantity of a cryptocurrency to be transferred; a first input provided from an output of a first invitation transaction from a first user, the first invitation transaction previously included on the P2P distributed ledger, a first script, a first user private key associated with the first user, a first third-party private key associated with a first third-party, and a first output indicating a transfer of a first entity from the first user to a second user; and wherein the first script comprises: a first set of metadata providing an indication of the first entity to be transferred and a first set of conditions for the transfer, a first user public key associated with the first user, the first user public key being a cryptographic pair with the first user private key, and a first third-party public key associated with the first third-party, the first third-party public key being a cryptographic pair with the first third-party private key.
Patent EP-4249066-A2 (EP)
Inventor: MAURER MARK F
IPC: A61P35/00
Filed: 2015-12-22
Abstract: The present invention provides antibodies, or antigen binding fragments thereof, that bind to human TIGIT (T cell immunoreceptor with Ig and ITIM domains), as well as uses of these antibodies or fragments in therapeutic applications, such as in the treatment of cancer or chronic viral infection. Such method of treatment include combination therapy with inhibitors of other immunomodulatory receptor interactions, such as the PD-1/PD-L1 interaction. The invention further provides polynucleotides encoding the heavy and/or light chain variable region of the antibodies, expression vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies, cells comprising the vectors, and methods of making the antibodies or fragments by expressing them from the cells.
Patent EP-4249537-A2 (EP)
Title: Multistage process with hydrothermal liquefaction
Inventor: GUTIERREZ ANDREA
IPC: C08H8/00
Filed: 2021-06-11
Abstract: The disclosure relates to a process for converting lignocellulosic feedstock (10) to renewable product (80), wherein the process comprises the following steps; treating (100) lignocellulosic feedstock (10) with aqueous solution (20) to obtain a mixture (30); heating (110) the mixture (30) of step (a) to a temperature between 290 and 340 °C, under a pressure from 90 to 120 bar, to obtain a first product mix (40); separating aqueous phase (53) and oil phase (50), and optionally gas (51) and solids (52), of the first product mix (40) of step (b); and heating (130) the oil phase (50) of step (c) and solvent (60). The heating (130) is optionally followed by fractionation (200) to obtain a light fraction (90) and a heavy fraction (91) and optionally a bottom residue fraction (92) and/or a gaseous fraction.
Patent EP-4276635-A2 (EP)
Inventor: TOMISHIMA SHIGEKI
IPC: G06F12/02
Filed: 2017-01-16
Abstract: Examples include techniques for a write zero operation. Example techniques include forwarding a write 0 command to a memory device to cause internal activations of column select lines of one or more blocks of memory to cause bit values or contents of the one or more blocks to have or store a value of 0.
Patent EP-4287590-A2 (EP)
Inventor: LAKSHMANAN BARATH
IPC: H04L67/12
Filed: 2018-03-19
Abstract: One embodiment provides for a method of performing machine learning operations for an autonomous vehicle, with determining that a computational workload is to be processed by a computing device of the autonomous vehicle, determining a first latency to a remote datacenter via an autonomous vehicle network, dispatching at least a first portion of the computational workload for processing via the remote datacenter when the first latency is below a threshold associated with the computational workload, determining a second latency to an autonomous vehicle within range of wireless network device in response to a determination that the first latency is above the threshold associated with the computational workload, and dispatching at least a second portion of the computational workload in response determining that the second latency is below the threshold associated with the computational workload.
Patent EP-4310382-A2 (EP)
Inventor: BRITTON JULILAN
IPC: F16L101/60
Filed: 2019-11-14
Abstract: A pipe repair apparatus for repairing partially collapsed pipes. The pipe repair apparatus comprises: an actuation assembly comprising: a plurality of actuation arms; a plurality of hydraulic cylinders; and a plurality of hydraulic lines, wherein each hydraulic line in the plurality of hydraulic lines supplies hydraulic fluid to a respective hydraulic cylinder in the plurality of hydraulic cylinders, wherein each hydraulic cylinder in the plurality of hydraulic cylinders is configured to move a respective actuation arm in the plurality of actuation arms between a retracted configuration and an extended configuration to move a partially collapsed part of a partially collapsed pipe from a partially collapsed form to a non-collapsed form. The pipe repair apparatus comprises a control module configured to control each individual hydraulic line in the plurality of hydraulic lines such that each actuation arm in the plurality of actuation arms is actuated independently.
Patent EP-4293702-A2 (EP)
Title: Reducing detector wear during calibration and tuning
Inventor: GUCKENBERGER GEORGE B
IPC: H01J49/00
Filed: 2018-03-27
Abstract: A method of operating a mass spectrometer comprising: detecting a first ion species using a first gain setting of a detector or a first emission current for a first mass-to-charge range; detecting a second ion species using a second gain setting of the detector or a second emission current for a second mass-to-charge range; and using the detected first and second ion species to calibrate the mass range of a mass analyzer of the mass spectrometer, to tune the resolution of the mass analyzer, or to tune an ion optic of the mass spectrometer.
Patent EP-4296186-A2 (EP)
Inventor: RICE IAN SCOTT
IPC: B65D51/22
Filed: 2019-03-22
Abstract: A beverage pod for a beverage machine is provided. The beverage pod can include a container having an internal space and a container flange defining an opening to the internal space, a plug sealing the opening of the container, and a cap secured to the container flange. A beverage medium can be located within the internal space of the container. The cap can be operable to selectively engage a portion of the plug to release the beverage medium through the plug and the cap.
Patent EP-0012842-A2 (EP)
Inventor: KING FRANCIS KONG
IPC: G11B5/60
Filed: 1979-11-19
Abstract: The specification describes an assembly of a pair of magnetic transducers (400) held substantially in contact with opposite sides of a flexible magnetic disk wherein each transducer has a pair of disk contacting lands (404,406) each broadening from the leading edge (404b) to the trailing edge (404c), with the leading edge (404b) and side edge (404d) of each land being gradually blended into the surrounding active surface of the transducer and with the trailing edge (404c) of the land being sharp. A first one (404) of the lands of each transducer has a read/write magnetic gap (28U) in it, and in use (this land is located opposite the second land (not having the read/write gap in it) of the other transducer, the second land being wider than the first land in each case. The centres of the opposing lands are in alignment, the centres being located on a plane passing through the read/write gaps of the transducers.