Patent SG-11201809620U-A (SG)
Title: The contorsbody - a single chain target binder
Inventor: DENGL STEFAN
IPC: C07K16/00
Filed: 2017-05-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111011111111101 IIIIIIIIIIIIIIIIIII101110111111110111111011111011111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/191101 Al 09 November 2017 (09.11.2017) WIP0 I PCT (51) International Patent Classification: Egenhofenstr. 26 b, 82152 Planegg (DE). PLATZER, C07K 16/00 (2006.01) Josef; Schlierseeweg 9, 82538 Geretsried (DE). (21) International Application Number: (74) Agent: SKOLAUT, Alexander et al.; Roche Diagnostics PCT/EP2017/060354 GmbH, Patent Department (LPP 6164), P.O.Box 11 52, 82372 Penzberg (DE). (22) International Filing Date: 02 May 2017 (02.05.2017) (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (26) Publication Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (30) Priority Data: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, 16167920.4 02 May 2016 (02.05.2016) EP KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (71) Applicant (for all designated States except US): F. HOFF- MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, 124, 4070 Basel (CH). SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant (for US only): HOFFMANN-LA ROCHE INC. [US/US]; Great Notch, 150 Clove Road, 8th Floor, (84) Designated States (unless otherwise indicated, for every Little Falls, New Jersey 07424 (US). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (72) Inventors: DENGL, Stefan; Schleissheimer Str. 44a, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 80333 Muenchen (DE). GEORGES, Guy; Am Berggraben = TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, — 11, 82392 Habach (DE). HESSE, Friederike; Ganghofer- EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, = str. 23, 80339 Muenchen (DE). IMHOF-JUNG, Sabine; MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = = = (54) Title: — _ = = = = THE CONTORSBODY - A SINGLE CHAIN TARGET BINDER (57) : Herein is reported a circular fusion polypeptide comprising a first part of a binding domain, a second part of a Figure 2A binding domain and a spacer domain, wherein the spacer domain is a polypeptide and comprises at least 25 amino acid residues, the first part of the binding domain is a polypeptide and is fused via a first linker to the N- terminus of the spacer domain, the second part of the binding domain is a polypeptide and is fused via a second linker to the C-terminus of the spacer domain, the _ = . . _ . . . first part of the binding domain and the second part of the binding = domain are associated with each other and form a binding site = c - — that specifically binds to a target. = . .. - .-- Il Ill . © Il ii Il C:r Il Ir ... ' Il © ei C [Continued on next page] WO 2017/191101 Al MIDEDIMOMOIDEIROIDEMOMOIHMOVOIDIROIIMOVOIMIE TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with amended claims (Art. 19(1)) — with sequence listing part of description (Rule 5.2(a))