baber/WOPTO huggingface dataset:
Patent SG-11201811068Y-A (SG)
Title: Prl3 antibody
Inventor: ZENG QI
IPC: A61P35/00
Filed: 2017-06-14
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111011111111101 1111111111111111111111111111111111111111111111111111111111111111111111111 Organization 0 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/217934 Al 21 December 2017 (21.12.2017) WIP0 I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07K 16/40 (2006.01) A61P 35/00 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 39/395 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (21) International Application Number: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, PCT/SG2017/050300 DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (22) International Filing Date: KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 14 June 2017 (14.06.2017) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (25) Filing Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (26) Publication Language: English TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 10201604834P 14 June 2016 (14.06.2016) SG kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (71) Applicant: AGENCY FOR SCIENCE, TECHNOLO- UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, GY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, #20-10 Connexis North Tower, Singapore 138632 (SG). EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (72) Inventor: QI, Zeng; c/o Agency for Science, Technology MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, and Research, 1 Fusionopolis Way, #20-10 Connexis North TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Tower, Singapore 138632 (SG). KM, ML, MR, NE, SN, TD, TG). (74) Agent: SPRUSON & FERGUSON (ASIA) PTE LTD; Declarations under Rule 4.17: = P.O. Box 1531, Robinson Road Post Office, Singapore _ of inventorship (Rule 4.17(iv)) 903031 (SG). _ = Title: PRL3 ANTIBODY — (54) (57) : The present invention relates to humanised antibodies that bind = phosphatase of regenerating liver-3 (PRL3) and use of said antibodies for the =- treatment of cancer. Also claimed is an in vitro method of determining the cel- lular localisation of PRL3 in a cell, wherein expression of PRL3 at the cell sur- face indicates that the cell is cancerous. Pl• . = = Figure lA = = 1 ariorf • - = = = 11 ,Imeoloms) 11' en Figure 1B C:r IN Il el i t --- -- - - — - IN Il Figure 1C N C [Continued on next page] WO 2017/217934 Al MIDEDIMOM010101110101110010i010E1 IEDOHEMOVOIS Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))
Patent AT-405133-B (AT)
Title: Device for handling a patient
IPC: A61H33/00
Filed: 1997-02-04
Granted: 1999-05-25
Abstract: Device for handling, in particular for washing, patients with limited mobility, in particular bedridden patients, having a warm water source arranged on a portable frame 1, a shower 14, 161 which can be hydraulically connected to the warm water source and a water drain connected to a drain water container, and having a height-adjustable accommodation feature 13 for the patient, with at least one opening. So that even persons with severely limited power of movement can be handled by a single carer, provision is made for a transport device to be provided which can be extended horizontally, is manufactured from a flexible material and includes an accommodation feature 13 with a large number of openings.
Patent AT-401503-B (AT)
Title: Skip, especially for the collection of refuse
IPC: B65D88/12
Filed: 1993-03-17
Granted: 1996-09-25
Abstract: A refuse skip having a lateral suspension means for releasable suspension on hydraulically actuated pivot arms of a vehicle, a rear flap and a locking device serving to lock the latter, which locking device possesses a pivot unit arranged on the skip and projecting downwards beyond the skip bottom and has a transverse bolt which can be coupled to a catch hook on the vehicle when the skip is tilted and moves the locking device into the unlocking position, is designed in a simpler manner, and more reliably with regard to the locking and unlocking functions, in that the pivot unit with transverse bolt is arranged below the rear region of the skip, in that a spring arrangement engages on the pivot unit and prestresses the latter in its high position, in contact with the skip bottom, in which position the locking member is in its locking position, and in that the spring arrangement possesses a dead- centre position lying between the locking position and the unlocking position of the locking device, so that the pivot unit, after passing through the dead centre position, is also prestressed by the spring arrangement in its low position. <IMAGE>
Patent DK-162339-B (DK)
Inventor: AFCHAIN JEAN
IPC: B62D29/00
Filed: 1985-02-15
Abstract: 1. A container or large bucket for lorry, being particularly intended for the conditioning, storage and transport of powdered products in bulk, said container or large bucket (1) comprising concurrent lateral walls, such as the longitudinal walls (3, 4) and the bottom plates (2) defining between them the storage volume, said walls (2 to 4) being reinforced with cross-bars fastened to the lateral walls, such as the stiffening cross-bars (6) of the longitudinal walls (3, 4) and/or the reinforcement cross-bars (7) of the bottom plates (2), characterized in that it comprises one or several assembling sections (9 ; 10) disposed on the level with the edges of concurrence of two adjacent lateral walls (2, 3, 4), having a web (11) whose the longitudinal axis corresponds to said edge of concurrence, around which are distributed at least : a first wing (12) whose the plan is appreciably parallel with this of the first lateral wall, on which is fastened the latter, a second wing (13), integral with said first wing (12), whose the plan is appreciably parallel with this of the second lateral wall, on which is fastened the latter, a third wing (15 ; 16), integral with said first wing, whose the plan is transversely disposed with respect to said first wing (12), said first (12) and second (13) wings having means (17, 18) for positioning the sheet-metals constituting the concurrent lateral walls (2, 3, 4) suitable for positioning the respective edges of the sheet-metals with respect to the edge of concurrence, said first (12) and third (15 ; 16) wings substantially constituting the means for positioning the cross-bars (6, 7) suitable for positioning the ends of the stiffening cross-bars (6) and the reinforcement cross-bars (7).
Patent HU-192743-B (HU)
Inventor: GROO RUDOLF
IPC: C11D3/00
Filed: 1982-01-26
Abstract: A találmány szerint 20-55 tömegrész (I) általános képletű alkilbenzolszulfonsavat, ahol x értéke 5 és 13 közötti, előnyösen 8 és 10 közötti egész szám, 20-55 tömegrész (II) általános képletű etoxilezett zsiralkilaminnal, ahol a jelentése 10 és 22 közötti, előnyösen 14 és 18 közötti egész szám, míg y jelentése 10 és 20 közötti előnyösen 13 és 17 közötti egész szám, és 5-25 tömegrész (III) általános képletű dialkilamino-alkanollal, ahol b jelentése 1 vagy 2 és z jelentése 2 vagy 3, reagáltatunk, és adott esetben hozzáadunk a reagensek 100 tömegrész összmennyiségére számítva 10-20 tömegrész ismert bőrvédő adalékot, előnyösen kökuszzeirsav-monovagy -dietanolamidot vagy annak etoxilezett származékait, további adalékként adott esetben 10-50 tömegrész alkil-fenil-polietilénglikolétert és/vagy 10-50 tömegrész etoxilezett zslralkoholt, higítószerként pedig 300-500 tömegrész vizet.  192743 -1-
Patent HU-188162-B (HU)
Title: Process for preparing triphenyl-imidazole derivatives
Inventor: PHILLIPS ARTUR P
IPC: C07D233/54
Filed: 1982-02-11
Abstract: This invention is concerned with certain trlphenylimidazoles compounds of formula (I) <CHEM> in which R and R min  are identical or different and may be hydrogen; a lower alkyl having 1 to 4 carbons; phenyl; phenyl substituted with one or more lower alkyl groups having from 1 to 4 carbons, lower alkoxy groups having from 1 to 4 carbons or halogen atoms, e.g. Br or Cl; phenylalkyl (optionally substituted on the phenyl ring with one or more lower alkyl groups having from 1 to 4 carbons, lower alkoxy groups having 1 to 4 carbons or halogen atoms, e.g. Br or Cl); or taken together from a cyclic substituent of 5 or 6 members containing in addition to the nitrogen atom an optional second hetero atom selected from the groups consisting of oxygen nitrogen and sulfur. This invention is also taken to include the acd addition salts and solvates of the compounds of formula (I). These compounds are useful as antithrombotic, antiinflammatory, antipyretic and analgesic agents.
Patent HU-189566-B (HU)
Inventor: HORVATH JENOE
IPC: B65B55/02
Filed: 1982-03-09
Abstract: A találmány konzervipari sterilező berendezésre vonatkozik, melynek lényege, hogy függőleges kígyózó mozgást végző serleges szállítólánca, ennek pályáját körülvevő, fokozatosan növekvő, illetve csökkenő hőmérséklet- és nyomásterü, ezek nyomásával száraiban különböző szintű folyadéktar- talmával egyensúlyt tartó U-cellák révén osztott előmelegítő, valamint egyenlő szintű folyadéktartalmú elöhütövel ellátott, osztott hűtő szakasza között elrendezett sterilező tere van és ez a sterilező tere egy vagy több, száraiban azonos szintű folyadékot tartalmazó U-cellával meg van osztva. -5-+· E -T—M—+-S-E -k H—  -1-
Patent HU-196842-B (HU)
Title: Process for producing hybrid dna and bonding composition comprising the same
Inventor: MOORE KEVIN W
IPC: G01N33/531
Filed: 1983-03-14
Abstract: Transformed expression vectors or plasmids carry a ds DNA sequence that codes for only a desired part of a polypeptide chain of a protein or enzyme and is equipped for initiation and termination codons at the 5 min - and 3 min -termini respectively of said DNA sequence; in particular they carry a ds DNA sequence that codes for a variable region of a light or heavy chain of an immunoglobulin specific for a predetermined ligand but lacks nucleotides coding for aminoacid residues superfluous to said variable region. Methods for their preparation and hosts transformed by them are also disclosed. Cultivation of such transformed hosts yields the desired polypeptides, which can be isolated. Preferred polypeptides are provided in the form of compositions containing the variable regions of the light and heavy chains of immunoglobulins, since these are useful especially for diagnosis and therapy.
Patent HU-210314-B (HU)
Title: Process for preparation of 4-(alkyl with 1-4 carbon atoms)-2-(difluormethyl)-6-(trifluormethyl)-3,5-pyridine-dicarboxilyc-di(alkyl 1-4 carbonatoms)-esters
Inventor: MILLER WILLIAM HAROLD
IPC: C07D213/80
Filed: 1991-03-18
Abstract: Described herein is a process for preparation of 5 substituted pyridine dicarboxylate compounds.
Patent HU-208329-B (HU)
Title: Process for the dimerization of alpha-olefins having 2-5 carbon atoms
Inventor: SATO HIROSHI
IPC: C07C2/26
Filed: 1989-02-28
Abstract: A dimer of a lower  alpha -olefin is prepared by dimerizing a lower alpha -olefin in the presence of a catalyst comprising     (A) nickel chloride,   (B) a trialkylaluminum (C) at least one phosphorus compound selected from the group consisting of compounds of the formulae:  PR<1>R<2>R<3>      (I)  P(NR<1>2)3      (II)  and  P(OR<1>)3      (III) wherein R<1>, R<2> and R<3> are the same or different and each represents an alkyl group, a cycloalkyl group or a phenyl group and   (D) 1,1,1,3,3,3-hexafluoroisopropanol, wherein the catalyst has improved activity because of the use of nickel chloride as a nickel component, so that the amounts of expensive trialkylaluminum and hexafluoroisopropanol can be decreased and the cost of the catalyst is significantly reduced. r
Patent YU-49035-B (YU)
Title: Guide system for textile goods
Inventor: REINDERS PETER
IPC: B65H20/06
Filed: 1997-05-12
Abstract: Via a textile guide system for flat textile goods, the textile goods are fed by a continuous conveyor to processing stations and the textile web is fed between conveyor elements of the continuous conveyor and a stationary support whereby means is provided to press the textile web against the stationary support and whereby each pressing member has a vertical guide means in which a housing-fixed holding pin engages and apart from the guide means at least one pressing spring means is provided whereby the noise formation is largely suppressed. The vertical guide means is close to the oncoming end of the pressing member approached by the conveyor and the pressing spring means is arranged close to the downstream end of the pressing means.
Patent ZA-95858-B (ZA)
Title: Phenylacetic acid derivatives preparation thereof and intermediates therefor and compositions containing them
Inventor: BAYER HERBERT
IPC: C07D307/42
Filed: 1995-02-03
Abstract: Phenylacetic acid derivs. of formula (I), and their salts. X = NOMe. CHOMe, CHMe or CHEt; R<1> = H or Q; m = 0, 1 or 2; R<2> = CN, NO2, CF3, halo, Q or QO; R<3> = H, CN, NO2, OH, NH2, halo, Q, QO, QS, QNH ; R<4> = H, Cy, CyO, CyS, CyNH, Ar, ArO, ArS; Q = 1-4C alkyl; Cy = 3-6C cycloalkyl; Ar = aryl; R<5> = H, 1-10C alkyl, Cy, 2-10C alkenyl, 2-10C alkynyl, 2-10C alkenylcarbonyl, 1-10C alkycarbonyl, 3-10C alkynylcarbonyl or 1-10C alkylsulphonyl.
Patent AT-402970-B (AT)
Title: Freezer (low-temperature chest)
IPC: F25D23/06
Filed: 1995-10-19
Granted: 1997-10-27
Abstract: A freezer 1 has an essentially prismatic chest body 2 in whose insulating wall 3 an evaporator (refrigerant) battery 7 runs on the inside and a eutectic cold holdover (cold-hold plate) 8 is installed. In order to achieve an efficient cold holdover in a simple way, the cold holdover 8 comprises individual tube lengths 9, 10 filled with eutectic medium (mixture) which have lengths adapted to the straight-line sections 11, 12 of the evaporator battery 7, determined by the wall 3 of the freezer 2, and are laid along these straight-line sections 11, 12. <IMAGE>
Patent AT-383540-B (AT)
Title: Screw for a plastics extruder
IPC: B29C48/85
Filed: 1983-05-26
Granted: 1987-07-10
Abstract: The screw of a plastics extruder has an axially running, airtight-sealed bore, in which a liquid heat transfer medium is arranged. To achieve substantial axial temperature equalization, a capillary system comprising a number of layers of wire mesh is provided on the inner wall of the bore. <IMAGE>
Patent AT-393641-B (AT)
Title: Apparatus for bending steel rods to form concrete reinforcing elements
Inventor: RITTER GERHARD DIPL ING DR
IPC: B21D43/00
Filed: 1989-09-20
Granted: 1991-11-25
Abstract: Apparatus for bending steel rods to form concrete reinforcing elements, with a device 3 for feeding rods to a transfer device 8, by means of which a respective group of rods can be inserted between bending members 11,12 in the transverse direction of the rods, the transfer device having at least one pair of gripping tongs 10 which can be actuated in a controlled manner and can be pivoted out of a receiving position, in which they receive a plurality of rods from the rod feed device and clamp these rods, into an insertion position, in which they insert the rods into the space between the bending members. <IMAGE>
Patent AT-402345-B (AT)
IPC: F28D1/03
Filed: 1993-12-16
Granted: 1997-04-25
Abstract: The invention describes a panal radiator with built-in valve and connection fitting (3) which is equipped with a control valve (5) situated at the side and near the top of the radiator, mounted to the radiator panel supply connection (6), and which comprises connecting pipes (13, 14) that run from the control valve (5) and from a radiator panel return connection (10) to screwed joints (12) at the bottom of the radiator that can be loosened on the radiator side. The screwed joints (12) are situated in the center of the underside (4c) of the radiator (1); from these screwed joints one connecting pipe (13) fixed inside the radiator leads to the control valve (5), and another connecting pipe (14) fixed inside the radiator (1) leads to a radiator panel return connection (10) mounted at the bottom of the radiator (1) in the half of the radiator opposite the control valve (5). These connecting pipes (13, 14) are preferably made of steel.
Patent AT-396863-B (AT)
IPC: A43B5/04
Filed: 1988-11-18
Granted: 1993-12-27
Abstract: PCT No. PCT/AT89/00103 Sec. 371 Date Jul. 6, 1990 Sec. 102(e) Date Jul. 6, 1990 PCT Filed Nov. 16, 1989 PCT Pub. No. WO90/05465 PCT Pub. Date May 31, 1990.In a ski boot with a rear part (3), which can be bent or folded back, for rear entry, with a lower shell (1) and an upper (4) that can swivel relative to lower shell (1), swivable upper (4) exhibits a flap (5), which runs in the peripheral direction of upper (4) and backward to rear part (3) and is placed overlaping the upper on the outside in a region of upper (4) facing the toe of the boot and lying perpendicular to the longitudinal median plane of the boot, and flap (5) with its free end region can be connected to upper (4) at various vertical positions. In this case, flap (5) on its free end region exhibits a tunnel-shaped protuberance (7), and a fastening element for fastening a strap-shaped tightening element (6) is placed on upper (4) in the region of tunnel-shaped protuberance (7) of flap (5) and the width of tightening element (6) is smaller than the inside width of tunnel-shaped protuberance (7), to be able to fasten flap (5) to upper (4) independently of the closing forces of tightening element (6).
Patent CH-629644-B (CH)
Inventor: SAUNIER JEAN-JACQUES
IPC: G04B39/00
Filed: 1980-05-22
Abstract: An encaging frame (2) extends substantially over the whole height of the case. This frame fits freely into the middle/bezel (1) and its upper edge serves as axial support for a mineral glass (4) fixed by means of a seal (7). The glass can be removed, with the movement, by pushing on the lower part of the encaging frame (2). <IMAGE>
Patent CH-638074-B (CH)
Inventor: SEKIYA FUKUO
IPC: G04G3/02
Filed: 1981-07-08
Abstract: In an electronic timepiece having a primary frequency divider circuit coupled to receive a standard frequency signal and comprising a group of P-channel FETs and a group of N-channel FETs, a bias circuit supplies a bias input to the P-channel FET group and a separate bias input to the N-channel FET group. By providing these bias inputs through current mirror coupling from a standard current source, the response of the primary frequency divider circuit to low amplitudes of the standard frequency signal can be made substantially independent of timepiece battery voltage variations, over a wide range of battery voltages.
Patent DK-158568-B (DK)
Inventor: CALANCHI MASSIMO
IPC: B01J13/02
Filed: 1981-04-09
Abstract: The invention relates to a process for preparing microcapsules in a liquid vehicle, allowing to microencapsulate both water soluble and water insoluble substances, using either ionic or non-ionic systems, in which the membrane enclosing the core of the microcapsules is formed by a polymer selected from the group of the phthalates, and more particularly by hydroxypropylmethylcellulose phthalate.
Patent DK-164352-B (DK)
Inventor: JEROME ARON
IPC: A01D80/02
Filed: 1988-03-30
Abstract: The outside part 17 of each tool-carrying arm 10 is offset in relation to the inside part 18 is that the center of gravity G of the set comprising the outside part 17 and the associated work tools 11 is located at least approximately on the longitudinal axis of rotation 16.
Patent DK-159043-B (DK)
Title: Wheeled suitcase
Inventor: HOYE WILLY VAN
IPC: A45C5/14
Filed: 1986-05-05
Abstract: A suitcase is provided with a rotating wheel (13) or roller mounted for rotation on an axle (22). The axle (22) is secured to resilient shock-absorbing means in the form of a disc of hard rubber (23) which is in turn secured to a mounting plate (24) fixed to the suitcase wall (26). This arrangement allows vibrations resulting from contact of the wheel (13) with the ground to be absorbed before they reach the case.
Patent DK-149122-B (DK)
Inventor: WELLBROCK WERNER
IPC: C07C231/00
Filed: 1980-10-09
Abstract: A process for the continuous preparation of diacetyl ethylene diamine, w hich comprises allowing a mixture of ethylene diamine and acetic acid to react in a low-temperature zone at a temperature of about 80 DEG  to 140 DEG  C., completing the reaction of the mixture in a subsequent high-temperature zone of from about 140 DEG  to 215 DEG  C., discharging the diacetyl ethylene diamine obtained at the end of the high-temperature zone and stripping the reaction water in countercurrent flow by an inert gas at a point located between the low-temperature and the high-temperature zone.
Patent DK-163403-B (DK)
Title: Method and device for separating the skeletal parts from a carcass
Inventor: NORLING LARS-ERIK
IPC: A22B/
Filed: 1989-10-27
Abstract: PCT No. PCT/SE88/00207 Sec. 371 Date Oct. 26, 1989 Sec. 102(e) Date Oct. 26, 1989 PCT Filed Apr. 25, 1988 PCT Pub. No. WO88/08250 PCT Pub. Date Nov. 3, 1988.The skeleton bones in a carcass are separated from this in a continuous process course with the aid of supporting manual incisions and a mechanical force applied on the skeleton bones and the carcass, while the carcass is transported along a sliding conveyor hanging in its meat-hook. The speed and the force with which the carcass is transported are guided and controlled independent of each other. The carcass hangs on a meat-hook during the course without attachment so that it can move freely on the hook in all planes, while it is driven forward by means of a pushing arm applied across the carcass. The skeleton part of the carcass which is to be separated is attached by way of a supported meat-hook on the sliding conveyor while the rest of the carcass is driven along the conveyor.
Patent DK-157546-B (DK)
Inventor: TOJA EMILIO
IPC: C07D405/10
Filed: 1979-12-19
Abstract: 3H-naphth[1,2,-d] imidazole derivates of formula 
<CHEM>
 wherein R stands for (C1-6)alkyl, (C3-6)alkenyl, (C3-6)alkynyl or (33-7)cycloalkyl, R1 and R2, each independently may represent hydrogen, halogen, (C1-4)alkyl, (C1-4)alkylthio, (C1-4)alkoxy or halo(C1-4)alkoxy and the symbol A represents a 5- or 6-membered heteroaromatic ring or a phenyl radical optionally substituted, are claimed. 
<??>Also described and claimed are processes for preparing the novel compounds, their use as antiinflammatory and antimicrobial agents and pharmaceutical compositions containing them.
Patent FI-94061-B (FI)
Inventor: CROMPTON GEOFFREY
IPC: C08K3/00
Filed: 1988-04-11
Granted: 1995-03-31
Abstract: A composition is provided comprising two or more frits capable of melting progressively as the temperature rises in a fire situation, one of the said frits being a relatively high- melting frit which is a defitrifying frit. The composition may be added to a variety of materials to provide or enhance fire resistance; such materials include phenolic and polyester resins and sodium silicate.
Patent FI-95506-B (FI)
Inventor: HANNIBALSEN FOLMER OSVALD
IPC: F25D17/04
Filed: 1992-01-09
Granted: 1995-10-31
Abstract: The storing space of a freezer (10) communicates with a flexible bag (30) arranged on the outside of the freezer. The bag takes up the volume changes which the air in the space goes through as a consequence of normal temperature oscillation of cooling surfaces (14) in the space. By this, the humidity of ambient air is prevented from being sucked into the space past the lid or door sealing (20) of the freezer and form frost on the cooling surfaces (14). <IMAGE>
Patent FI-108721-B (FI)
Inventor: PEET NORTON PAUL
IPC: A61P25/28
Filed: 1992-03-11
Granted: 2002-03-15
Abstract: The present invention relates to certain novel 8-substituted purines as selective A1-adenosine receptor antagonists which are useful in the treatment of patients suffering from Alzheimer's disease, congestive heart failure or pulmonary bronchoconstriction.