Patent SG-11201809526Y-A (SG)
Title: Anti-microbial compositions
Inventor: PERCIVAL STEVEN
IPC: C07C229/16
Filed: 2017-05-04
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2017/191453 Al 09 November 2017 (09.11 2017) W I P0 I P C T (51) International Patent Classification: (72) Inventors: PERCIVAL, Steven; 6 Castle Hill, Pulford, A01N 1/02 (2006.01) A61K 33/24 (2006.01) Chester CH4 9EY (GB). CHEN, Rui; 70 Woodsorrel Road, A01N 59/16 (2006.01) C07C 229/16 (2006.01) Liverpool L15 6UD (GB). HUNT, John Alan; 8 Thorstone A61K 31/198 (2006.01) Drive, Irby CH61 4XR (GB). (21) International Application Number: (74) Agent: APPLEYARD LEES IP LLP; 15 Clare Road, Hal- PCT/GB2017/051243 ifax Yorkshire HX1 2HY (GB). (22) International Filing Date: (81) Designated States (unless otherwise indicated, for every 04 May 2017 (04.05.2017) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (25) Filing Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (26) Publication Language: English DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (30) Priority Data: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, 1607814.9 04 May 2016 (04.05.2016) GB MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (71) Applicant: 5D HEALTH PROTECTION GROUP LTD PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, [GB/GB]; 4 Gwel Y Mynydd, Clynnog Farm Dwyran, Llan- SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, fairpwllgwgngyll, Gwynedd LL61 6RR (GB). TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (54) Title: ANTI-MICROBIAL COMPOSITIONS = = 1800 1600 = „'” ` -...., •:\ 1400 E 1200 • CONTROL a ..a...S. aureus biofilm 1000 — ? Medium change '...',.• 50PPM = 800 - -+-Treatment c 4 —10OPPM = y , • a+ 0 6 0 _ c 400 = = , 200 = 0 = D1 D4 D5 D6 = — Time (Days) = = Fig. 4 ,-1 .4 fn (57) : A metal-EDTA compound/complex for combatting biofilms and/or treating wounds. The compound/complex comprises kr) 7 1. EDTA and from two to four metal ions. Of those two to four metal ions, at least two are different metal ions selected from Ag, Al, Il Au, Ba, Bi, Tl, Ce, Co, Cu,Fe, Ga, Ir, Mo,Rh, Ru, Ti, and Zn ions. The metal-EDTA compound/complex may exhibit any one or C:N more of anti-microbial, anti-biofilm and anti-inflammatory activities in use and may increase the susceptibility of a biofilm and the 1-1 ----. microorganisms within said biofilmto attack by anti-microbial agents, helping to remove and sanitise the biofilm. A composition, wound IN dressing and medical device comprising the metal-EDTA complex are also provided. Uses of the metal-EDTA compound/complex as © a medicament and/or to sanitise and/or substantially remove a biofilm from a substrate are also disclosed. N O [Continued on next page] WO 2017/191453 Al MIDEDIMOMOIDEIROIDEMOMOHHOEHINOMOVOIMIE (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))