baber/WOPTO huggingface dataset:
Patent CA-2744985-C (CA)
Inventor: ANDO NAOKO
IPC: C07D277/36
Filed: 2009-12-01
Granted: 2014-05-06
Abstract: A compound represented by general formula (I) or a pharmaceutically acceptable salt thereof has excellent PPAR.alpha.  agonist action and lipid-lowering action, and is useful as a preventive or therapeutic agent for hyperlipidemia, etc. In general formula (I), R1 and R2 independently represent a hydrogen atom, an alkyl group, or the like; R3 represents a hydrogen atom, an alkyl group, or the like; R4 represents a hydrogen atom, an alkyl group, or the like; m represents an integer of 0 to 3; X represents a bond, an oxygen atom, or a sulfur atom; Y represents a carbonyl group, a hydroxymethylene group, or the like; and Z represents a halogen atom, an alkyl group, an aryl group, a heteroaryl group, or the like.
Patent CA-2745448-C (CA)
Inventor: ENEVER CAROLYN
IPC: C12Q1/37
Filed: 2009-12-04
Granted: 2018-09-18
Abstract: The invention relates to a method for selecting, isolating and/or recovering a peptide or polypeptide from a library or a repertoire of peptides and polypeptides (e.g., a display system) that is resistant to degradation by a protease such as a protease found in the serum. Generally, the method comprises providing a library or repertoire of peptides or polypeptides, incubating the library or repertoire with a protease under conditions suitable for protease activity, and selecting, isolating and/or recovering a peptide or polypeptide that is resistant to degradation by the protease and has a desired biological activity. The selected peptides and polypeptides have utility as therapeutics, e.g. for treating disease in humans.
Patent CA-2746055-C (CA)
Inventor: SHAO LIMING
IPC: C07D209/08
Filed: 2009-12-15
Granted: 2016-12-13
Abstract: Provided herein are bicyclic compounds of general Formula I: (see formula I) and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders. Compounds provided herein inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations containing the compounds are also provided.
Patent CA-2751743-C (CA)
Title: Dispositif motorise de mesure de coordonnees
Inventor: EATON HOMER L
IPC: G05B19/19
Filed: 2009-01-30
Granted: 2016-07-19
Abstract: La présente invention concerne un dispositif de mesure de coordonnées (10) qui comprend un boîtier (12) supporté de manière rotative sur une base (11) et surmontant un pilier vertical (13) le long duquel circule un chariot (14) dans lequel s'insère un bras (15) effectuant des translations horizontales. Un barillet (18, 19) à chaque extrémité du bras loge un corps en rotation (20, 21) connecté à une sonde (22, 23). La rotation de la base, le mouvement vertical du chariot, le mouvement horizontal du bras et la rotation des sondes sont effectués par des moteurs (27, 28, 29, 30) dans le boîtier. La rotation des moteurs est transmise par un câble et un assemblage de poulies au bras et au chariot. Les extrémités opposées du câble (43) contrôlant le mouvement transversal du bras sont attachées à l'extrémité opposée (16, 17) du bras, et ce câble circule respectivement vers le haut et vers le bas de la partie du pilier ci-dessus et en dessous du chariot de sorte à maintenir constantes les longueurs et la tension des câbles pendant que le chariot se déplace vers le haut et vers le bas du pilier. La rotation des sondes et celle de la base sont coordonnées pour garder les sondes à un angle constant par rapport à la surface mesurée.
Patent CA-2754938-C (CA)
Title: Anti-bcma antibodies
Inventor: KALLED SUSAN L
IPC: A61K39/395
Filed: 2010-03-10
Granted: 2016-10-11
Abstract: This invention provides antibodies or antigen-binding fragments that recognize the B Cell Maturation Antigen (BCMA), compositions thereof, as well as hybridomas that produce the antibodies or fragments. The invention further provides uses of the antibodies or fragments for depleting plasma cells which express BCMA, for reducing the level of autoantibodies in a subject that expresses BCMA, and for treating B cell-related disorders associated with BCMA  expression.
Patent CA-2757736-C (CA)
Inventor: CARMICHAEL ADRIAN
IPC: B65D81/26
Filed: 2010-04-08
Granted: 2017-07-18
Abstract: A closure (40) includes a body (42) with a screw threaded portion (44) for engaging the closure with a container, for example a bottle. Inwards of portion (44) is a liner (46) comprising a hydrogen generating device, wherein the liner includes one layer (48) which incorporates a hydride dispersed in a polymeric matrix and, on opposite sides of layer (48) are arranged PET  layers (50, 52). Layer (50) is arranged to act as a control layer to control the rate of passage of water vapour from the beverage in the container to the hydride containing layer (48) and thereby control generation of hydrogen by the hydrogen generating device.  In use, water vapour passes through layer (50) and contacts the hydride associated with layer (48) which results in production of molecular hydrogen which combines with oxygen which may have entered a container with which the closure (40) is associated.  Thereafter, a reaction between the hydrogen and oxygen takes place, catalysed by a catalyst associated with the container thereby to scavenge the oxygen.
Patent CA-2765019-C (CA)
Inventor: GRIGSBY ROBERT A
IPC: B27N3/18
Filed: 2010-06-15
Granted: 2018-07-03
Abstract: Lignocellulosic composites are made by pressing a mixture of a particulate lignocellulosic material with polymeric MDI, in the presence of a fatty amine ethoxylate anti- masking agent.
Patent CA-2770936-C (CA)
Title: Cadre d'extension pour caisse ou palette de transport
Inventor: HUG YVES
IPC: B65D19/18
Filed: 2012-03-12
Granted: 2014-12-02
Abstract: Un châssis dextension pour une boîte de transport ou une palette comprend deux longs côtés et deux côtés transversaux pliables. Une pièce angulaire est formée sur un des côtés transversaux ou sur un des côtés longs, la pièce angulaire comportant une extrémité libre formant une charnière avec une extrémité libre dun côté long ou dun côté transversal adjacent. La charnière est pourvue à létat ouvert et à létat plié dune position de verrouillage à laquelle le côté long et le côté transversal adjacent peuvent être mis en prise.
Patent CA-2773698-C (CA)
Inventor: GARCON NATHALIE
IPC: A61K9/14
Filed: 1999-10-08
Granted: 2015-05-19
Abstract: The present invention provides vaccine and adjuvant formulation comprising an immunostimulant and a metal salt. The immunostimulant is adsorbed onto a particle of metal salt and the resulting particle is essentially devoid of antigen.
Patent CA-2777949-C (CA)
Title: Appareil facilitant les operations urologiques
Inventor: SINGH ERROL O
IPC: A61B17/94
Filed: 2004-05-21
Granted: 2013-01-29
Abstract: Un câble de visionnement à fibres optiques pour vision directe souple (80) pouvant s'introduire dans un cathéter urinaire (IQ), dont le bout est situé à l'extrémité distale du cathéter (10) de manière que les surfaces de l'extrémité distale du câble de visionnement (80) et du cathéter (10) soient alignées afin de s'assembler et former une surface composite à courbe régulière pour faciliter le contournement des obstructions. Le câble (80) est maintenu en position de manière que le cathéter (10) et les surfaces comprenant le bout de l'instrument demeurent alignés. Il est possible de visualiser l'urètre durant la procédure d'insertion, en tout ou en partie, afin d'observer et de déterminer les obstructions qui pourraient être présentes, puis le câble (80) est retiré tout en permettant au cathéter (10) de demeurer en place dans l'urètre. L'invention comprend également un cathéter (10) qui sert de gaine de travail et un obturateur (50). L'invention facilite l'examen endoscopique et peut servir à effectuer des procédures chirurgicales par le biais de la gaine.
Patent CA-2780101-C (CA)
Title: Ensemble couche de confort
Inventor: COATES FREDRICA V
IPC: A61F13/505
Filed: 2010-07-27
Granted: 2016-01-05
Abstract: L'invention concerne un ensemble couche 2 comprenant un vêtement 10 pour couche et une garniture absorbante 60 pour fluides. Le vêtement 10 pour couche est doté d?une enveloppe extérieure 12 à laquelle est suspendue une sangle 20. Ladite sangle 20 est résistante aux fluides et comporte des poches avant et arrière 34, 36 dans lesquelles des extrémités opposées de la garniture absorbante 60 pour fluides peuvent être insérées. La poche avant 34 est formée d?un écran 50 résistant aux fluides, qui est entouré sur trois côtés par des goussets 40, 42 qui sont plus confortables pour la peau que ne l?est l?écran 50. La sangle 20 est capable de porter des garnitures 60 multicouches.
Patent CA-2782849-C (CA)
Inventor: BOKKER FOKKE
IPC: F17C9/02
Filed: 2010-11-30
Granted: 2017-10-24
Abstract: L'invention concerne un procédé ainsi qu'un dispositif pour augmenter l'enthalpie d'un milieu, de l'énergie étant extraite d'un premier fluide caloporteur constitué d'un premier gaz de fumée (5) et d'un deuxième fluide caloporteur (W) comprenant de l'eau et du gaz de fumée et l'énergie étant transmise par échange de chaleur indirect au milieu, un deuxième gaz brûlé (3) étant injecté pour former le deuxième fluide caloporteur (W) dans un système matériel contenant de l'eau. Le premier fluide caloporteur (9) refroidi par rapport au milieu est utilisé pour former le deuxième fluide caloporteur (W).
Patent CA-2784140-C (CA)
Inventor: MILAM STANLEY NEMEC
IPC: C01G39/06
Filed: 2011-01-21
Granted: 2018-01-09
Abstract: A method for producing a thiometallate or selenometallate material is provided in which a first salt containing an anionic component selected from the group consisting of MoS4 2-, MoSe4 2-, WS4 2-, WSe4 2- and a second salt containing a cationic component comprising copper in any non-zero oxidation state are mixed under anaerobic conditions in an aqueous mixture at a temperature of from 50°C to150°C.
Patent CA-2785815-C (CA)
Inventor: HAREL MOTI
IPC: A23L33/00
Filed: 2011-01-28
Granted: 2018-04-24
Abstract: The present invention relates to formulations and methods for stabilizing and protecting of biologic materials during harsh storing and use conditions, wherein the formulations relate to embedded bioactive materials and biologics, including live bacteria, in a protective glassy matrix.
Patent CA-2788669-C (CA)
Inventor: BAKER BRETT HUGH JAMES
IPC: A61K31/29
Filed: 2011-02-03
Granted: 2021-05-25
Abstract: La présente invention concerne des compositions et des procédés, comprenant de nouvelles suspensions microparticulaires homogènes, qui sont destinés à traiter des surfaces naturelles contenant des biofilms bactériens, comprenant des effets synergétiques ou amplificateurs insoupçonnés entre des composés bismuth-thiol (BT) et certains antibiotiques, pour fournir des formulations comprenant des formulations antiseptiques. L'invention concerne également les propriétés antibactériennes et anti-biofilm précédemment inattendues des composés BT et des combinaisons composé BT-plus-antibiotique décrites, comprenant les efficacités préférentielles de certaines de telles compositions pour traiter certaines infections par des bactéries gram-positives, et les efficacités préférentielles distinctes de certaines de telles compositions pour traiter certaines infections par des bactéries gram-négatives.
Patent CA-2793794-C (CA)
Inventor: MORISSET LOPEZ SEVERINE
IPC: G01N33/542
Filed: 2011-04-01
Granted: 2018-02-20
Abstract: The present invention relates to a system comprising coupling products formed by a monomer of a protein chosen from Lingo-1, Lingo-2, Lingo-3 and Lingo-4 and by a probe emitting a signal when said monomer undergoes conformational changes, and to a screening method using said system, enabling ligands of a protein chosen from Lingo-1, Lingo-2, Lingo-3 and Lingo-4 to be identified. The present invention is industrially applicable in the field of methods for detecting molecules, for detecting interaction between molecules and for molecular screening, and also in the medical field.
Patent CA-2794121-C (CA)
Inventor: DOVE JEFFREY S
IPC: D06M10/00
Filed: 2011-03-23
Granted: 2016-10-11
Abstract: Cette invention concerne des méthodes de conditionnement d'un matériau bioprothétique utilisant la membrane du péricarde bovin. Un laser dirigé sur la surface fibreuse de la membrane et déplacé sur ladite surface permet de réduire l'épaisseur de la membrane à une valeur uniforme spécifique et d'en lisser la surface. La longueur d'onde, la puissance et le taux d'impulsion du laser sont sélectionnés de manière à lisser la surface fibreuse et à la rogner jusqu'à obtenir l'épaisseur appropriée. En variante, un dermatome est utilisé pour éliminer une couche de matériau de la surface fibreuse de la membrane. L'amincissement de la membrane peut également être obtenu par compression. La compression effectuée par étapes et avec réticulation pour stabiliser la membrane est utilisée pour éviter de léser ladite membrane par une compression inélastique. La membrane est plus exactement liée à l'état comprimé élastique par réticulation d'addition. Les techniques de réduction de l'épaisseur qui viennent d'être énoncées peuvent être utilisées ensemble pour obtenir des membranes minces et solides. La membrane finale amincie peut ensuite être traitée par coiffage de sites de nucléation de calcification et par réduction au borohydrure. Les feuillets peuvent être conçus de manière à présenter plusieurs zones d'épaisseur uniforme, par exemple une zone de couture périphérique plus épaisse.
Patent CA-2795741-C (CA)
Title: Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
Inventor: RENAUD JEAN-LUC
IPC: C07D223/16
Filed: 2012-10-24
Granted: 2015-09-08
Abstract: La présente invention concerne un procédé de synthèse de l'ivabradine de formule (I) : (voir formule I) de ses sels d'addition à un acide pharmaceutiquement acceptable et de ses hydrates.
Patent CA-2798036-C (CA)
Inventor: TCHIR WILLIAM JOSEPH
IPC: G16C20/10
Filed: 2012-12-05
Granted: 2020-01-21
Abstract: Selon linvention, lapplication déquations détat à des données expérimentales et littérature permet la formation dun modèle et dun diagramme de phase(s) qui montrent dans quelles conditions le polyéthylène est susceptible de précipiter à lextérieur dune solution à haute pression de polyéthylène dans de léthylène supercritique. Ceci permet ensuite une meilleure définition pour faire fonctionner un réacteur haute pression pour réduire la probabilité de séparation de phase, de perte de refroidissement et potentiellement de décomposition du contenu du réacteur.
Patent CA-2800084-C (CA)
Inventor: HIPP MARKUS
IPC: A61B10/02
Filed: 2011-05-27
Granted: 2015-11-24
Abstract: The invention relates to a joint biopsy needle (1) for taking tissue samples and to a method therefor. The joint biopsy needle (1) has a trocar tip (2) and a substantially rigid guide sleeve (11), which adjoins a base surface (23) of the trocar tip (2) and has a lateral opening (12) in a region adjacent to the trocar tip (2). The biopsy needle (1) also has a plunger (3), which can be displaced in the guide sleeve (11) in the longitudinal direction thereof and has a cutting blade (31) on a side (30) that faces the trocar tip (2), wherein the tissue which is to be taken in the region of the lateral opening (12) of the guide sleeve (11) and can enter the guide sleeve (11) through the lateral opening (12) can be severed by the cutting blade (31). The guide sleeve (11) is inserted into a handle (6). To this end, the guide sleeve (11) is curved at least in one location between the trocar tip (2) and the handle (6), wherein the displaceable plunger (3) can be displaced by means of a flexible force transmitting element (8) that is guided in the guide sleeve (11). Thus a biopsy needle is obtained which is simple to operate and by means of which tissue samples can be taken effectively even in sampling locations that are inconveniently located and at times difficult to access.
Patent CA-2802604-C (CA)
Inventor: STECKEL HARTWIG
IPC: A61K47/10
Filed: 2011-06-24
Granted: 2018-11-06
Abstract: Pharmaceutical composition for oral administration comprises at least one phosphodiesterase inhibitor and at least one sugar alcohol selected from mannitol, sorbitol, xylitol, maltitol, lactitol, erythritol, threitol and Isomalt, and sodium hydrogen carbonate as pharmaceutical excipients in the following weight proportions:  phosphodiesterase inhibitor:  about 10 to about 150 parts by weight in total; sugar alcohol: about 50 to about 600 parts by weight in total; and sodium hydrogen carbonate: about 2 to about 100 parts by weight. The above composition for use in a method of treating male erectile dysfunction with an accelerated onset of action is also disclosed.
Patent CA-2805264-C (CA)
Title: Product pricing in e-commerce
Inventor: MOHAPATRA MIHIR PRASAD
IPC: G06Q30/02
Filed: 2013-02-07
Granted: 2021-03-30
Abstract: Systems and methods for dynamically fixing price of a product in an electronic commerce (e-commerce) environment are described. In one embodiment, the method comprises obtaining product information associated with the product. Further, the method comprises extracting a real time market price of at least one product constituent indicated in the product information from at least one market information source. Furthermore, the method comprises evaluating a market price factor for the product based on the extracting, where the market price factor is indicative of impact of market conditions onto the price of the product. Based at least on the product information and the market price factor, a real time selling price of the product may be fixed.
Patent CA-2806785-C (CA)
Title: Fuel air heat exchanger
Inventor: PROCIW LEV ALEXANDER
IPC: F28D1/04
Filed: 2013-02-20
Granted: 2020-02-25
Abstract: A fuel air heat exchanger for a gas turbine engine having fuel and air conduits in heat exchange relationship with one another, and a distribution conduit in heat exchange relationship with a component to be cooled. The distribution conduit is in fluid communication with the outlet of each air conduit. The heat exchanger also includes a secondary air inlet in fluid communication with the distribution conduit and a flow selection member selectively movable between first and second configurations. In the first configuration, the flow selection member closes the fluid communication between the secondary inlet and the distribution conduit. In the second configuration, the flow selection member opens the fluid communication between the secondary air inlet and the distribution conduit.
Patent CA-2810022-C (CA)
Title: In situ upgrading via hot fluid injection
Inventor: PEREIRA-ALMAO PEDRO
IPC: E21B43/30
Filed: 2013-03-19
Granted: 2014-12-09
Abstract: The invention relates to systems, apparatus and methods for integrated recovery and in-situ (in reservoir) upgrading of heavy oil and oil sand bitumens. The systems, apparatus and methods enable enhanced recovery of heavy oil in a production well by introducing a hot fluid including a vacuum or atmospheric residue fraction or deasphalted oil into the production well under conditions to promote hydrocarbon upgrading. The methods may further include introducing hydrogen and a catalyst together with the injection of the hot fluid into the production well to further promote hydrocarbon upgrading reactions. In addition, the invention relates to enhanced oil production methodologies within conventional oil reservoirs.
Patent CA-2811692-C (CA)
Title: Novel block copolymer and micelle compositions and methods of use thereof
Inventor: GAO JINMING
IPC: A61K47/32
Filed: 2011-08-11
Granted: 2020-02-18
Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R' is -H or -CH3, wherein R is -NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.
Patent CA-2814660-C (CA)
Title: Systeme et procede de protection contre les surtensions
Inventor: WAGONER ROBERT GREGORY
IPC: H02J3/14
Filed: 2013-05-02
Granted: 2017-02-07
Abstract: Dans un aspect, la présente invention a trait à un procédé visant à assurer une protection contre les surtensions dans un système électrique. Le procédé peut généralement comprendre la détection dun état de surtension dans un système électrique et lactivation, en réponse à létat de surtension détecté, dune impédance reliée au système électrique, limpédance bloquant la tension dans le système électrique.
Patent CA-2819925-C (CA)
Inventor: CHEHAIBER MOATASEM
IPC: G06F17/30
Filed: 2011-12-15
Granted: 2018-04-17
Abstract: La présente invention porte sur un procédé et un dispositif de découverte de voisin le plus proche. En particulier, l'invention porte sur le tri, la recherche et l'appariement de données multidimensionnelles, telles que des vecteurs, de façon à trouver le voisin le plus proche. Le procédé est particulièrement utile en tant que partie d'un algorithme SIFT.
Patent CA-2824897-C (CA)
Inventor: JONSSON ANDERS
IPC: A61F2/01
Filed: 2009-09-04
Granted: 2017-09-19
Abstract: An embolic protection device (200) and medical procedure for positioning the device in the aortic arch (100) is disclosed. The device and method effectively prevent material (150) from entering with blood flow into side branch vessels (116, 118, 120) of the aortic arch. The device is a collapsible embolic protection device devised for temporary transvascular delivery to an aortic arch of a patient, wherein the device has a protection unit that comprises a selectively permeable unit adapted to prevent embolic material from passage with a blood flow into a plurality of aortic side branch vessels at the aortic arch. The protection unit is permanently attached to a transvascular delivery unit (130) at a connection point provided at the selectively permeable unit, and a first support member for the protection unit that is at least partly arranged at a periphery of the selectively permeable unit. In an expanded state of the device, the connection point is enclosed by the first support member or arranged at said support member.
Patent CA-2828313-C (CA)
Title: Turbine comprising a sealing device between the stator blade carrier and the housing
Inventor: WROBEL ANDRAS
IPC: F02C7/28
Filed: 2012-02-27
Granted: 2015-01-27
Abstract: The invention relates to a turbine (1) of a power plant, preferably a steam turbine, comprising a stator (2), which has a housing (4) and in the housing (4) at least one stator blade carrier (5, 6, 7) comprising stator blades (8), a rotor (3), which has a rotor shaft (9) comprising rotor blades (11), and at least one sealing device (12), which axially seals the respective stator blade carrier (5, 6, 7) with respect to the housing (4) and separates two regions (20, 21) having different pressures from one another. Improved sealing action is achieved in that the sealing device (12) comprises an axially acting primary sealing ring (24) extending in the circumferential direction, said sealing ring facing the region (21) having the lower pressure, and an axially acting additional sealing ring (25) extending in the circumferential direction, said sealing ring facing the region (20) having the higher pressure. The primary sealing ring is attached axially rigidly on the stator blade carrier and the additional sealing ring is attached axially movably, wherein the additional sealing ring is tensioned axially in the direction of the region having the higher pressure by means of at least one spring element.