Patent SG-11201909331U-A (SG)
Title: Antigen-specific immune effector cells
Inventor: VODYANYK MAKSYM
IPC: C07K16/28
Filed: 2018-04-18
Abstract: TNK cells () INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 October 2018 (25.10.2018) WIP0 I PCT IiiimuolionommillomomimEmolommornovoimill (10) International Publication Number WO 2018/195175 Al (51) International Patent Classification: C07K 14/725 (2006.01) C12N 5/0783 (2010.01) A61K 38/17 (2006.01) C12N 5/074 (2010.01) A61K 35/17 (2015.01) A61P 35/00 (2006.01) A61K 35/545 (2015.01) C07K 16/28 (2006.01) (21) International Application Number: PCT/US2018/028133 (22) International Filing Date: 18 April 2018 (18.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/486,875 18 April 2017 (18.04.2017) US (71) Applicant: FUJIFILM CELLULAR DYNAMICS, INC. [US/US]; 525 Science Drive, Suite 200, Madison, WI 53711 (US). (72) Inventors: VODYANYK, Maksym, A.; C/o Fujifilm Cel- lular Dynamics, Inc., 525 Science Drive, Suite 200, Madi- son, WI 53711 (US). ZHANG, Xin; C/o Fujifilm Cellular Dynamics, Inc., 525 Science Drive, Suite 200, Madison, WI 53711 (US). BRANDL, Andrew, J.; C/o Fujifilm Cellular Dynamics, Inc., 525 Science Drive, Suite 200, Madison, WI 53711 (US). RAJESH, Deepika; C/o Fujifilm Cellular Dy- namics, Inc., 525 Science Drive, Suite 200, Madison, WI 53711 (US). SWANSON, Bradley; C/o Fujifilm Cellular Dynamics, Inc., 525 Science Drive, Suite 200, Madison, WI 53711 (US). MUNN, Christie; C/o Fujifilm Cellular Dy- namics, Inc., 525 Science Drive, Suite 200, Madison, WI 53711 (US). BURTON, Sarah; C/o Fujifilm Cellular Dy- namics, Inc., 525 Science Drive, Suite 200, Madison, WI 53711 (US). WANG, Wen, Bo; C/o Fujifilm Cellular Dy- namics, Inc., 525 Science Drive, Suite 200, Madison, WI 53711 (US). MCLEOD, Ethan; C/o Fujifilm Cellular Dy- namics, Inc., 525 Science Drive, Suite 200, Madison, WI 53711 (US). (74) Agent: MANN, Monica; Parker Highlander PLLC, 1120 S. Capital Of Texas Highway, Bldg. One, Suite 200, Austin, TX 78746 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = (54) Title: ANTIGEN-SPECIFIC IMMUNE EFFECTOR CELLS iPSCs Lymphoid progenitors Genetic programming Transcription factors orift. eo 1 Th Directed differentiation Cytokines _1 FIG. 1A N 1-1 (57) : Provided herein are methods for the production of antigen-specific effector T cells and NK cells from pluripotent © stem cells which express a chimeric antigen receptor (CAR). Further provided herein are methods for the adoptive cell therapy by C administering the effector T cells and/or NK cells provided herein. [Continued on next page] WO 2018/195175 Al MIDEDIM011111 11111111E101301M1101011111111111111011110111111 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))