Patent SG-11201903950U-A (SG)
Title: Truncated von willebrand factor polypeptides for treating hemophilia
Inventor: SCHULTE STEFAN
IPC: A61P7/04
Filed: 2017-11-10
Abstract: International Patent Classification: A61K 38/36 (2006.01) CO7K 14/755 (2006.01) A61K 38/37 (2006.01) A61P 7/04 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (21) International Application Number: PCT/EP2017/078834 Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (22) International Filing Date: 10 November 2017 (10.11.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16198501.5 11 November 2016 (11.11.2016) EP (71) Applicant: CSL BEHRING RECOMBINANT FACILI- TY AG [CH/CH]; Wankdorfstrasse 10, 3014 Bern (CH). (72) Inventors: SCHULTE, Stefan; Bauerbacher Strasse 46, 35043 Marburg (DE). WEIMER, Thomas; Richard-Wag- ner-Strasse 8, 35075 Gladenbach (DE). PESTEL, Sabine; Stuempelstal 19, 35041 Marburg (DE). METZNER, Hu- bert; Im Boden 6, 35041 Marburg (DE). DOWER, Steve; 18 Percy Street, Fitzroy North, Victoria 3068 (AU). (74) Agent: LUDWIG, Holger et al.; Emil-von-Behring- Strasse 76, 35041 Marburg (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, N N cc O cc O C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 17 May 2018 (17.05.2018) WIPO I PCT omit VIII °nolo III m mom VIII 100 Imo oimIE (10) International Publication Number WO 2018/087267 Al (54) Title: TRUNCATED VON WILLEBRAND FACTOR POLYPEPTIDES FOR TREATING HEMOPHILIA (57) : The invention pertains to a polypeptide comprising a truncated von Willebrand Factor (VWF) and a half-life extending moiety, for use in the treatment of a blood coagulation disorder, said treatment comprising administering the polypeptide to a subject having a blood coagulation disorder and having endogenous Factor VIII (FVIII), wherein the activity level of endogenous FVIII in said subject before treatment with said polypeptide is reduced relative to the activity level of FVIII in normal human plasma (NHP) provided that the activity level of endogenous FVIII in said subject is at least 0.5% of the activity level of endogenous FVIII in normal human plasma (NHP), wherein the polypeptide is capable of binding to endogenous FVIII and wherein the endogenous FVIII level is increased following administration of said polypeptide.