baber/WOPTO huggingface dataset:
Patent CA-2776004-A1 (CA)
Inventor: ORIENTE FRANCESCA
IPC: C12N15/67
Filed: 2010-09-30
Abstract: The meningococcal fhbp gene (encoding factor H binding protein) is naturally expressed from two independent transcripts by two differentially regulated promoters. In one transcript it is co-expressed with the neighbouring upstream gene from the P nmb1869 promoter. The other transcript is monocistronic and is expressed from its own dedicated promoter, Pfhbp, which is activated by the global regulatory protein FNR in response to oxygen-limiting conditions. To increase expression of the monocistronic transcript a constitutively-active FNR mutant is used. The Pfhbp promoter can thus be activated, leading to over-expression of FNR-activated genes, such as fhbp.
Patent CA-2776924-A1 (CA)
Inventor: WITTENBERGER DAN
IPC: A61F2/958
Filed: 2010-10-25
Abstract: A medical device is provided that may include a catheter body having proximal and distal portions, a fluid injection lumen disposed within elongate body, and a guidewire lumen disposed within the elongate body. A tip portion defining a cavity in fluid communication with the fluid injection lumen may be coupled to the distal end of the guidewire lumen, and an expandable element may be coupled to the distal portion of the catheter body and to the tip portion, such that the expandable element is in fluid communication with the fluid injection lumen. A shaping element may at least partially surround the expandable element, where the shaping element is configurable in a first geometric configuration and a second geometric configuration.
Patent CA-2777071-A1 (CA)
Inventor: HITCHCOCK MARION
IPC: A61K31/18
Filed: 2010-10-12
Abstract: The present invention relates to substituted halophenoxybenzamide derivative compounds of general formula (I) in which R1, R2, R3, R3a, R4, R5, R6, Ra, Rb, Rc, and X are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
Patent CA-2777537-A1 (CA)
Title: Compositions and methods for mild sedation, anxiolysis and analgesia in the procedural setting
Inventor: PALMER PAMELA
IPC: A61K31/485
Filed: 2010-10-14
Abstract: Small tablets for use in procedural sedation, anxiolysis and analgesia comprising the combination sufentanil and triazolam administered via the oral transmucosal route and methods for using the same are provided.
Patent CA-2778872-A1 (CA)
Inventor: KUNERT ANJA
IPC: C12N15/10
Filed: 2010-12-14
Abstract: The present invention refers to a method for identifying hetero-multimeric ubiquitins with binding capability to a ligand. Furthermore, the invention provides DNA libraries encoding for a population of said hetero-multimeric ubiquitins as well as protein libraries obtained by expression of said DNA libraries, cells and phages containing said DNA or proteins, polynucleotides encoding for said fusion proteins and vectors comprising said polynucleotides. Further new binding proteins based on hetero-multimeric ubiquitin being able to bind specifically with high affinity to selected ligands are provided.
Patent CA-2781053-A1 (CA)
Title: Simultaneous detection of mutational status and gene copy number
Inventor: SINGH SHALINI
IPC: G01N33/567
Filed: 2010-12-30
Abstract: The present invention provides compositions and methods for simultaneously detecting mutational status and gene copy number. In particular, the present invention provides simultaneous measurement of gene copy number and detection of the L858R and Exon 19 del mutations in a tissue sample.
Patent CA-2782680-A1 (CA)
Title: Modular infuser with continuous filter belt
Inventor: OVERTON NIGEL
IPC: A47J31/00
Filed: 2010-12-01
Abstract: A modular infuser 200 includes a back plate assembly 201 containing drive mechanisms and supporting a belt assembly 205, an infusing chamber 204, and a mixing chamber 802 The belt 5 assembly includes rollers rotating a continuous filter belt 400, an annular seal 401, and a funnel directing liquid to a spout 206 The infusing chamber moves between having the bottom clamped to the seal through the filter belt and being spaced apart from the filter belt to allow 10 waste removal by rotation of the filter belt The mixing chamber receives and mixes ingredients and water, passing the mixture into the infusing chamber below Replacement of the filter belt with different mesh sizes and of the removable spout with different inner diameters allows the mechanism to be easily adapted for 15 different beverages, such as coffee or tea.
Patent CA-2783176-A1 (CA)
Title: Mid-ir microchip laser: zns:cr2+ laser with saturable absorber material
Inventor: MIROV SERGEY B
IPC: H01S3/06
Filed: 2002-09-19
Abstract: A laser includes a substrate formed of a II-VI semiconductor material, grooves formed at an input end of the substrate and input fibers that engaged to the grooves to receive multiple input optical beams of pump light. The laser further includes optical waveguides formed in the substrate that are respectively coupled to the input fibers, where one waveguide corresponds to one input fiber, and where the optical waveguides extend to an output end of the substrate to form multiple output optical ports. Additionally, the laser includes a laser gain region doped with transitional metal ions in the substrate that overlap with the optical waveguides near the output optical ports, where the laser gain region absorbs the pump light to produce laser gain at multiple laser wavelengths within a broadband luminescence spectral range different from the pump wavelength to generate laser light at the multiple laser wavelengths. The laser further includes a tapered grating formed in the laser gain region to have different grating pitches at the different optical waveguides so that the tapered grating selects different laser wavelengths in the different optical waveguides, respectively, to cause laser output of the different selected laser wavelengths at the output optical ports.
Patent CA-2784804-A1 (CA)
Title: Optical fiber handler for a fiber optic connection termination system
Inventor: BARNES BRANDON A
IPC: G02B6/25
Filed: 2011-01-05
Abstract: An optical fiber handler (10) for optical connector termination systems and other devices are disclosed herein. The optical fiber handler attaches to the optical fiber (30) or cable (34) and cooperates with other components for preparing the optical fiber and/or making the optical connection, thereby providing a simple, reliable, and easy termination for the optical fiber. For instance, the handler may cooperate with one or more of the following a strip tool, strip/clean tool, cleave tool for preparing the end of the optical fiber (s), and/or a mechanical splice connector for making the optical connection. Additionally, after the optical fiber handler is attached to the mechanical splice connector it may be easily removed by the craft if necessary to reposition and reterminated the mechanical splice.
Patent CA-2784889-A1 (CA)
Title: Methods and compositions for diagnosis and prognosis of renal injury and renal failure
Inventor: ANDERBERG JOSEPH
IPC: G01N33/48
Filed: 2010-12-20
Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a plurality of assays, one or more of which is configured to detect a kidney injury marker selected from the group consisting of Hyaluronic acid, Immunoglobulin A, Immunoglobulin Gl, Immunoglobulin G2, Insulin-like growth factor-binding protein 7, Alpha- 1 antitrypsin, Serum amyloid P component, Metalloproteinase inhibitor 2, Hepatocyte growth factor, Intercellular adhesion molecule 1, Beta-2-glycoprotein 1, Interleukin-1 beta, Neutrophil Elastase, Tumor necrosis factor receptor superfamily member HB, Interleukin-11, Cathepsin D, C-C motif chemokine 24, C-X-C motif chemokine 6, C-C motif chemokine 13, C-X-C motif chemokines -1, -2, and -3, Matrilysin, Interleukin-2 receptor alpha chain, Insulin-like growth factor-binding protein 3, and Macrophage colony-stimulating factor 1 as diagnostic and prognostic biomarkers in renal injuries.
Patent CA-2787326-A1 (CA)
Title: Sole structure for a shoe
Inventor: IUCHI KAZUNORI
IPC: A43B5/06
Filed: 2011-03-28
Abstract: Disclosed is a sole structure which can reduce energy loss while running. A sole structure (1) for a shoe is provided with: an upper plate (3) which is disposed in the upper part of the sole structure (1) and which stretches from the front to the back of the sole; a lower mid-sole (4) which is made from a soft elastic member, is disposed below the upper plate (3), is fixed to the lower surface of the upper plate (3), and has a groove (41) which opens downwards and which stretches in the width direction of the sole; and bend restriction sections (10) which are provided in a bent state in the length direction of the sole between edge sections of the opening of the groove (41), and which connect the edge sections of the opening. When the sole starts bending, the bend restriction sections (10) allow the sole to bend from when the bend restriction sections (10) are in a bent state up until the bend restriction sections (10) are gradually stretched into a straight line between the edge sections of the opening, and when the sole has been bent, the bend restriction sections (10) restrict the bending of the sole by receiving force in the extension direction when the straight line is stretched between the edge sections of the opening.
Patent CA-2789428-A1 (CA)
Title: Ultrasonic surgical instruments with partially rotating blade and fixed pad arrangement
Inventor: ROBERTSON GALEN C
IPC: A61B17/3207
Filed: 2011-02-09
Abstract: An ultrasonic surgical instrument that supports an ultrasonically excited blade and an outer sheath that can be selectively rotated relative to each other to bring a distal cutting tip of the blade into contact with at least one cutting surface formed on a distal end of the outer sheath. In some embodiments, the distal cutting tip may contact two cutting surfaces located on opposing sides of an opening in the outer sheath through which the distal cutting tip protrudes. Tissue pads may be attached to the cutting surfaces. Various embodiments also include at least one suction lumen.
Patent CA-2789701-A1 (CA)
Inventor: MISHRA PRATIK KUMAR
IPC: H04L12/16
Filed: 2012-09-14
Abstract: Systems and methods for enhancing content quality and user engagement in social platforms are described. In one implementation, a method includes assessing a quality of each of a plurality of user contributed contents related to at least one topic associated with a web based social platform based at least on topic quality assessment parameters to generate a topic quality score for the at least one topic. Further, the method comprises generating a credibility score for each of a plurality of users who contributed the user contributed contents based in part on the topic quality score. Based on the credibility scores, at least one credible user from the plurality of users is identified to enhance at least one of quality of the web based social platform and user engagement in the web based social platform.
Patent CA-2790569-A1 (CA)
Inventor: FABVIER BRUNO
IPC: E04D5/12
Filed: 2011-02-22
Abstract: The invention relates to a method of making a grooved reinforced layered bituminous membrane (1) comprising the steps of: providing a web (A) of a reinforcing material, applying a layer (3) of a hot liquid adhesive, and applying a roller (10) having a surface pattern of grooves onto said layer (3) of an adhesive, to form a pattern of grooves (4) in the surface of said layer of an adhesive.
Patent CA-2791821-A1 (CA)
Inventor: WEISS UWE
IPC: B25J9/10
Filed: 2011-09-30
Abstract: The invention relates to a manipulation device for manipulating and/or processing a workpiece, comprising a first motion unit (12a) for generating a linear motion (B1) of a first component (22a) and a second motion unit (12b) for generating a linear motion (B2) of a second component (22b) The motion units (12a, 12b) are arranged relative to each other such that the motions (B1, B2) that can be generated by the motion units (12a, 12b) are aligned parallel to each other, wherein the first component (22a) is connected via a first hinge joint (24a, 26a) and the second component (22b) is connected via second hinge joint (24b, 26b) to a fastening element (29, 29') that is suitable for receiving a workpiece and/or a tool. The first hinge joint comprises a first guide arm that is coupled to the first component by means of a revolute joint, and the second hinge joint comprises a second guide arm (26b) that is coupled to the second component by means of a revolute joint. The first guide arm and the second guide arm are coupled directly or indirectly to each other by at least one revolute joint (24c, 24c1) so as to be pivotable relative to each other.
Patent CA-2793515-A1 (CA)
Inventor: RODGERS KATHLEEN E
IPC: A61K38/08
Filed: 2012-02-01
Abstract: The present invention provides methods and pharmaceutical formulations for treating diabetic foot ulcers.
Patent CA-2794147-A1 (CA)
Inventor: DESAI NEIL P
IPC: A61P35/00
Filed: 2011-03-28
Abstract: The present invention in one aspect provides methods of enhancing uptake of a therapeutic agent in a target tissue as well as methods of treating a disease (such as cancer) or enhancing effectiveness of treatment with a therapeutic agent in an individual by co-administering a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane with the therapeutic agent. The present invention in another aspect provides a method of treatment or a method of selecting patients for treatment of a disease (such as cancer) with the combination of a therapeutic agent and a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane based on one or more characteristics of the target tissue that correlates or indicates the capability of getting enhanced therapeutic agent uptake as a result of the co-administration of the taxane nanoparticle composition in the target tissue (referred to as "the drug uptake capability"). Also provided are pharmaceutical compositions, article of manufacture, and kits useful for methods described herein.
Patent CA-2794323-A1 (CA)
Inventor: DUWIG CHRISTOPHE
IPC: C10L1/02
Filed: 2011-03-02
Abstract: Method for the preparation of a compression ignition engine fuel, comprising the steps of providing a mixture of a primary hydrocarbon fuel comprising one or more alcohols; and dehydrating in the mixture the one or more alcohol to its or their corresponding ether and water, to obtain the compression ignition fuel.
Patent CA-2795963-A1 (CA)
Inventor: UMANSKY BENJAMIN S
IPC: C10G65/04
Filed: 2011-04-22
Abstract: A diesel fuel product with beneficial cold flow properties can be produced. A suitable feedstock for forming a diesel boiling range product can be hydrotreated to have a sulfur content of at least about 100 wppm and then dewaxed. This two stage process can allow for production of an arctic or winter diesel without use of high pressures. Optionally, a divided wall column fractionator can be used to allow a single separation stage to handle the effluent from both the hydroprocessing and the dewaxing stages.
Patent CA-2799163-A1 (CA)
Inventor: LEBOWITZ MICHAEL
IPC: G01N33/48
Filed: 2012-12-18
Abstract: A method of data interpretation from a multiplex cancer assay is described.  The aggregate normalized score from the assay is transformed to a quantitative risk score quantifying a human subject's increased risk for the presence of cancer as compared to the known prevalence of the cancer in the population before testing the subject.
Patent CA-2799264-A1 (CA)
Inventor: BLAIR PAUL M
IPC: G02B6/26
Filed: 2008-10-10
Abstract: Fiber optic connector end faces are cleaned effectively by exposing the fiber optic connector end face to the disclosed predominantly aqueous solution and wiping the fiber optic end face dry. The predominantly water-based cleaning solution contains water, water soluble organic solvents, propylene glycol ethers and isopropanol.  Also disclosed is a method for cleaning a fiber optic end face using an aqueous solution.
Patent CA-2800058-A1 (CA)
Title: Sleeve valve
Inventor: GEORGE GRANT
IPC: E21B34/14
Filed: 2012-12-24
Abstract: An sleeve valve for a well assembly includes at least one set of passages extending through a tubular body between the central passage and an exterior of the tubular body and a sleeve slidably located within the central passage of the valve body adapted to selectably sealably cover or uncover the at least one sets of passages. A shifting tool for actuating the sleeve valve is connectable to a tool string and includes a shifting bore with an actuating piston extending from a central bore through the shifting tool and first and second key bores extending radially inwards from the outer surface each having a piston keys located therein. Each of the first and second piston keys is operably connected to the actuating piston so as to be extended from the outer surface when the central bore is supplied with a pressurized fluid.
Patent CA-2801473-A1 (CA)
Inventor: ZHU QIAN
IPC: H04L47/762
Filed: 2013-01-10
Abstract: The workload profiler and performance interference (WPPI) system uses a test suite of recognized workloads, a resource estimation profiler and influence matrix to characterize un-profiled workloads, and affiliation rules to identify optimal and sub-optimal workload assignments to achieve consumer Quality of Service (QoS) guarantees and/or provider revenue goals. The WPPI system uses a performance interference model to forecast the performance impact to workloads of various consolidation schemes usable to achieve cloud provider and/or cloud consumer goals, and uses the test suite of recognized workloads, the resource estimation profiler and influence matrix, affiliation rules, and performance interference model to perform off-line modeling to determine the initial assignment selections and consolidation strategy to use to deploy the workloads. The WPPI system uses an online consolidation algorithm, offline models, and online monitoring to determine virtual machine to physical host assignments responsive to real-time conditions to meet cloud provider and/or cloud consumer goals.
Patent CA-2802158-A1 (CA)
Inventor: YOUNG CHRISTOPHER MICHAEL
IPC: D01G5/00
Filed: 2011-06-07
Abstract: An apparatus suitable for separating particles and methods for using such apparatus are provided.
Patent CA-2803194-A1 (CA)
Inventor: FORTIER LOUIS-PHILIPPE
IPC: A61B46/23
Filed: 2011-06-23
Abstract: A magnetic drape comprises a drape body made of a flexible material. The drape body has a panel portion having an undersurface adapted to be laid on an uneven body and a top surface, and a given thickness between the undersurface and the top surface. A plurality of magnet units are within the flexible material of the drape body, with each said magnet unit comprising a shielding material in the shape of a cup oriented to have a bottom wall facing toward the undersurface of the drape body, and a magnet received at least partially in the cup. The magnet comprises two or more sections arranged to expose opposite polarity on a top surface of the magnetic drape, with each said section having opposite polarities oriented vertically.
Patent CA-2803458-A1 (CA)
Inventor: CARLSSON OLA
IPC: A61K33/14
Filed: 2011-06-20
Abstract: The present invention concerns a dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with water, a sodium containing concentrate, and a bicarbonate containing concentrate into a ready-for-use dialysis solution. Said dialysis acid precursor composition consists of powder components comprising glucose, at least one dry acid and at least one magnesium salt, and optionally potassium salt, and calcium salt. According to the invention said glucose and said at least one magnesium salt, are present as anhydrous components in said dialysis acid precursor composition.
Patent CA-2805197-A1 (CA)
Title: Electromagnetic orientation system for deep wells
Inventor: KUCKES ARTHUR
IPC: E21B7/04
Filed: 2011-07-12
Abstract: An electromagnetic method and apparatus for determining the azimuthal orientation of a drill bit instrumentation sub (70), with respect to a borehole bottom drilling assembly (150) includes an electromagnet (152) fastened to the drilling assembly to produce an auxiliary alternating electromagnetic field (162) having an axis (163) that is perpendicular to the borehole axis (160). The direction of the field lines (162) generated by this magnet (152) and the simultaneous measurement of an electromagnetic field (36) generated by current flow in a blowout well casing is measured by electromagnetic field sensors in the drill bit instrument sub (70) to determine the direction to a blowout The direction of the auxiliary field (162) produced by the electromagnet (152) makes it possible to determine the direction to the blowout with reference to the direction of drilling without using an intermediate parameter such as, for example, the direction of gravity.
Patent CA-2807461-A1 (CA)
Inventor: YAMAMOTO TAKEYUKI
IPC: G05B19/418
Filed: 2011-07-29
Abstract: A fastening part tightening management system (1) that manages a tightening state of a fastening part such as a screw to fix a constituent part of an aircraft in an aircraft assembling process includes a manual torque wrench (2) that tightens a fastening part up to a set torque while activating a tightening torque and detects and transmits tightening torque information acting on the fastening part, a marking pen (3) that performs marking to the fastening part, the tightening operation of which is ended by the manual torque wrench (2), detects a writing pressure in the marking, and transmits marking completion information; an information processing device (5) that determines a tightening state of the fastening part based on the tightening torque information and the marking completion information, and a mobile information terminal (4) that notifies an operator of a determination result obtained by the information processing device (5).
Patent CA-2808196-A1 (CA)
Title: Peptide compound useful for inhibiting amyloid plaque formation
Inventor: MEDIANNIKOV OLEG
IPC: A61P25/28
Filed: 2011-10-24
Abstract: The present invention relates to a peptide compound having the following general formula (I) or (II): Ra-R1-R2-R3-R4-Rb (I) or Ra-R4-R3-R2-R1-Rb (II), in which - R1 is an amino acid residue H, R or K; - R2 is an amino acid residue A; - R3 is an amino acid residue E or D; - R4 is an amino acid residue E or D; - Ra is the N-terminal primary amino function of the amino acid R1 or R4, wherein said function is free or substituted with a protective group, - Rb is the hydroxyl function of the C-terminal carboxyl group of the amino acid R1 or R4, wherein said function is free or substituted with a protective group. The present invention also relates to the use of said useful peptide compound, in particular, for binding to ß-amyloid peptides and inhibiting polymerization thereof in the form of amyloid plaques, and, more particularly, use as a medicament or for preparing or determining a medicament with a view to treating a neurodegenerative disease, in particular Alzheimer's disease.
Patent CA-2808640-A1 (CA)
Inventor: LITZ KYLE E
IPC: C10G27/04
Filed: 2011-10-05
Abstract: A method of upgrading a heteroatom-containing hydrocarbon feed by removing heteroatom contaminants is disclosed. The method includes contacting the heteroatom-containing hydrocarbon feed with an oxidant to oxidize the heteroatoms, contacting the oxidized- heteroatom-containing hydrocarbon feed with caustic and a selectivity promoter, and removing the heteroatom contaminants from the heteroatom-containing hydrocarbon feed. The oxidant may be used in the presence of a catalyst.