baber/WOPTO huggingface dataset:
Patent DE-69637768-D1 (DE)
Inventor: WALLACH DAVID
IPC: A61P31/04
Filed: 1996-03-01
Granted: 2009-01-15
Abstract: PCT No. PCT/US96/03121 Sec. 371 Date Oct. 9, 1997 Sec. 102(e) Date Oct. 9, 1997 PCT Filed Mar. 1, 1996 PCT Pub. No. WO96/26738 PCT Pub. Date Sep. 6, 1996A controlled release pharmaceutical composition includes a biocompatible polymeric material, preferably polyethylene-vinyl acetate or poly(lactic-glucolic acid), having incorporated therein a soluble receptor capable of binding to its ligand and thus affecting the ligand's function. The soluble receptor is preferably the soluble form of TNF alpha  receptor. Such compositions are for use in the treatment of disorders in which neutralization of the deleterious effects of TNF alpha  is required.
Patent DE-69638106-D1 (DE)
Inventor: JONES DENNIS
IPC: A61K31/137
Filed: 1996-09-30
Granted: 2010-02-11
Abstract: Materials derived from Citrus plants can be administered orally to humans for the purpose of producing or maintaining weight loss as well as for improving the person's physical performance and increasing the person's lean muscle mass. The Citrus materials include those portions of the plant that are normally considered waste or inedible, such as the leaves, peel, and immature, unripe fruit. The materials contain at least one of the alkaloids from the group consisting of synephrine, hordenine, octopamine, tyramine and N-methyltyramine (1). Two species, Citrus aurantium and Citrus reticulata, are particularly useful. The materials can be administered in their natural form or as extracts, and can be administered in various ways including capsules and tablets. The Citrus materials may also be used as a tea. For weight loss and weight control, the materials can be administered concurrently with caloric restriction or in the absence of caloric restriction. The materials may also be administered for the purpose of increasing muscle mass concurrently with a high protein diet as well as with an exercise program.
Patent DE-69701999-D1 (DE)
Inventor: BERNARD FREDERIC
IPC: B65G51/03
Filed: 1997-06-04
Granted: 2000-06-15
Abstract: A device for conveying objects having a neck along a given direction having at least one pressure chamber capable of projecting an air flow on the objects along the conveying direction, and a support rail oriented along the conveying direction. The device includes transport shuttles fixed to the neck of the objects and cooperating with the support rail.
Patent DE-69702361-D1 (DE)
Inventor: YAMAMURO MIKIO
IPC: G11B7/004
Filed: 1997-03-12
Granted: 2000-08-03
Abstract: In this invention, in an optical disk (1) on which data is to be recorded in units of one ECC block constructed by 16 sectors, dummy data is recorded at the manufacturing time or at the initial time such as the application starting time, then the dummy data is reproduced to determine a sector with primary defect, the address of the sector which is determined to have the primary defect is recorded on the optical disk (1), and at the time of data recording, data recording is effected in units of one ECC block while skipping over the sector with the primary defect. Further, in the optical disk (1) on which data is to be recorded in units of one ECC block, data is recorded at the time of data recording other than the initial time, then the data is reproduced to determine an ECC block having a sector with secondary defect, and data of the ECC block which is determined to have the sector with secondary defect is recorded in an ECC block which is separately prepared. Further, in the optical disk (1) on which data is to be recorded in units of one ECC block constructed by 16 sectors, dummy data is recorded at the manufacturing time or at the initial time such as the application starting time, then the dummy data is reproduced to determine a sector with primary defect, the address of the sector which is determined to have the primary defect is recorded on the optical disk (1), data recording is effected in units of one ECC block while skipping over the sector with the primary defect at the time of data recording, data is recorded at the data recording time other than the initial time, the data is reproduced to determine an ECC block having a sector with secondary defect, and data of the ECC block which is determined to have the sector with secondary defect is recorded in an ECC block which is separately prepared. <IMAGE>
Patent DE-69706746-D1 (DE)
Inventor: DRECQ DANIEL
IPC: G01L3/22
Filed: 1997-03-17
Granted: 2001-10-25
Abstract: The measuring apparatus comprises an eddy current brake and torque meter (8). The eddy current brake has a stator (20) with stator windings (210) and an electrically conducting plate rotor (320) mounted on a shaft (310). The stator (20) is integrated with a supporting cage (10) and the shaft (310) is mounted on bearings (330,331) in the cage and stator. The motor being tested is connected through a coupling plate (70) and the torque is measured by the torquemeter (8) located adjacent to the stator. Water cooling is applied to the brake rotor through labyrinths (220).
Patent DE-69710039-D1 (DE)
Inventor: ANDREW BILL DEAN
IPC: B29D23/00
Filed: 1997-11-19
Granted: 2002-03-14
Abstract: A machine for use in butt fusing in axial alignment plastic pipe having a selected maximum diameter is adaptable by the use of specially designed inserts secured in the lower portions of fixed and moveable clamps, the inserts serving to elevationally raise segments of pipes to be joined when the machine is used to manufacture a segmented pipe turn. In addition to the employment of inserts providing increased height of support for pipe segments, the pivotal upper portions for the fixed and moveable clamps are replaced by specially designed upper clamp portions that have contacting surfaces configured to accept inclined and elevationally upwardly supported pipe segments. By the use of such specially designed inserts and replacement upper clamp portions a butt fusion machine can be employed to manufacture segmented pipe turns of the maximum pipe diameter for which the machine is designed. <IMAGE>
Patent DE-69713094-D1 (DE)
Inventor: BELLET DOMINIQUE
IPC: C12Q1/6886
Filed: 1997-02-28
Granted: 2002-07-11
Abstract: A process for detecting malignant transformation of cells involves detecting the overexpression of the products of the beta3, beta5, beta8 and beta9 genes, which encode the hCGbeta subunit, relative to their expression in nonmalignant cells. A kit for diagnosing an hCG- or an hCG fragment-secreting cancer includes an assembly of polypeptides covering at least a part of the primary sequence of hCG. The use of a polypeptide corresponding to at least one portion of the primary sequence of hCG for producing a composition useful in hCG- or hCG fragment-secreting cancer immunotherapy is also disclosed.
Patent DE-69717294-D1 (DE)
Inventor: THOMAS ANDREW PETER
IPC: C07D/
Filed: 1997-09-23
Granted: 2003-01-02
Abstract: 4-Anilino-quinazoline derivatives of formula (I) and their salts are new. m = 1 or 2; R1 = H, OH, halo, NO2, CF3, CN, 1-3C alkyl, alkoxy, or alkylthio, or NR5R6; R2 = H, OH, halo, MeO, amino, or NO2; R3 = OH, halo, 1-3C alkyl, alkoxy, or alkanoyloxy, CF3, CN, amino, or NO2; X1 = O, CH2, S, SO, SO2, NR7CO, CONR8, SO2NR9, NR10SO2, or NR11; R5, R6 = H or 1-3C alkyl; R7-R11 = H, 1-3C alkyl, or 1-3C alkoxy(2-3C alkyl); R4 = WR12 (linked through a C atom of R12), WR13, (2-5C alkenylene)-R14, (2-5C alkynylene)-R15, W-X2-W-X3-R16, W-X4-COR22, W-X5-R27, W-X6-W-R33, R39, W-R40, W-R43, or W-R44; when X1 = O, S, SO, or SO2, then R4 can also = 1-3C alkoxy 2-4C alkyl; when X1 = O, then R4 can also = 1-4C alkyl; and provided that, when R4 = W-X2-W-X3-R16, then X1 is not CH2; W = 1-5C alkylene; X2, X3 = as X1, but not CH2; X4 = O or NR23; X5 = OCO, or as X1, but not CH2; X6 = as X1, but not CH2; R12, R14, R15 = Het; Het = 5 or 6 membered saturated heterocyclyl, containing 1 or 2 heteroatoms from O, S, N (optionally containing 1 or 2 substituents G); G = oxo, OH, halo, 1-4C alkyl, alkoxy, or hydroxyalkyl, 1-4C alkanoyl, 2-5C alkoxycarbonyl, carbamoyl, or mono- or di- (1-4C alkyl)carbamoyl; R13 = pyrrolidin-1-yl, imidazolidin-1-yl, or thiomorpholinyl (optionally containing 1 or 2 substituents G); R16 = H or 1-3C alkyl; R22 = NR24R25 or OR26; R23-R26 = as R7; R27, R33 = cyclopentyl, cyclohexyl, or Het (all optionally containing 1 or 2 substituents G), or 1-3C alkyl; provided that, when R27 = 1-3C alkyl, then X5 is a group containing S, and X1 is not CH2; R39 = pyrrolidin-3-yl, piperidin-3-yl, or piperidin-4-yl (all optionally containing 1 or 2 substituents G); R40 = piperazin-1-yl (substituted by 1 or more 1-4C alkanoyl or hydroxyalkyl, 2-5C alkoxycarbonyl, or CONR41R42); R41, R42 = H or 1-4C alkyl; R43 = morpholinyl (optionally containing 1 or 2 substituents G); and R44 = morpholinyl (substituted by at least one, and optionally 2, G); provided that when R4 = alkoxyalkyl or alkyl then R1 and/or R2 = NO2 or \- 1 R3 = 1-3C alkanoyloxy.
Patent DE-69718504-D1 (DE)
Inventor: DICKINSON JOHN
IPC: F16L13/00
Filed: 1997-11-20
Granted: 2003-02-20
Abstract: A pipe connector (1) for a multi-layer composite pipe, the pipe comprising at least one reinforcing layer (13, 14), or layer of high axial strength, at least one inner thermoplastic layer (9, 10) and at least one outer protective layer (15, 16), the connector comprising: (i) a hollow, tubular enclosure (2) adapted to receive the pipe; (ii) fusion means adapted to make a fusion connection with the inner thermoplastic layer of the pipe; (iii) mechanical gripping means (7) adapted to grip the reinforcing layer, or layer of high axial strength of the pipe; and (iv) optionally sealing means (6) adapted to form an environmental seal with the outer protective layer of the pipe, the electrofusion means (8), mechanical gripping means and optional sealing means being disposed within the enclosure and the enclosure being adapted, in use, to apply a constraining force to the mechanical gripping means and the sealing means.
Patent DE-69722999-D1 (DE)
Inventor: ALLEN MICHAEL JOHN
IPC: A61P43/00
Filed: 1997-06-05
Granted: 2003-07-31
Abstract: Darifenacin, and its pharmaceutically acceptable salts, are useful in the treatment of cognitive impairment. The invention also discloses the use of combinations of darifenacin, or a pharmaceutically acceptable salt thereof, with an acetylcholinesterase inhibitor, in the treatment of cognitive impairment.
Patent DE-69729957-D1 (DE)
Inventor: SMITH DENNIS
IPC: A62B18/08
Filed: 1997-05-27
Granted: 2004-08-26
Abstract: A use-evident container for containing an object and selectively preventing elements outside said container to reach the object comprises two housing portions and two caps. The two housing portions define a chamber for surrounding an object. The housing portions each define at least one opening forming a first part of a fluid flow path between the chamber and outside of the housing. The caps close the at least one opening and have at least one cap hole forming a second part of the fluid flow path when the at least one opening and the at least one cap hole at least partially overlap one another. At least one cap connector rotatably connects the housing portions and the cap and enables the fluid flow path to be opened and closed by relative rotation of the housing portion and the cap. At least one single-use lock engages the housing portion and the cap and prevents the relative rotation. The lock holds the housing and the cap in a first relative position in which the fluid flow path is closed. The fluid flow path is openable only by the relative rotation to a second relative position and the relative rotation being possible only upon an unlocking of the single-use lock. The single-use lock thereafter permanently evidences the unlocking.
Patent DE-69733427-D1 (DE)
Inventor: KOYAMA MASAO
IPC: C07D401/12
Filed: 1997-06-27
Granted: 2005-07-07
Abstract: Since the compound of the present invention represented by the following formula (I) can strongly inhibit bonding of Ä<3>HÜ-serotonin and Ä<3>HÜ-5-CT to human serotonin 5-HT7 receptor subtype expressed in cultured cell line, the compound of formula (I) and pharmaceutically acceptable salts thereof can provide pharmaceutical conpositions for use in the treatment or prevention of mental diseases. <CHEM> ÄIn the above formula, A is N, CH, C having a double bond or CR<5>; each of B and Z is independently N, CH or CR<1>, with the proviso that A is N when B and/or Z is N; R<1> is a hydrogen atom, a halogen atom, a lower alkyl group, a cyano group, a trihalomethyl group, a hydroxy group, an alkoxy group, an alkylthio group, an alkylsulfinyl group, an alkylsulfonyl group, an alkoxycarbonyl group, a sulfamoyl group, an amino group, a substituted amino group, a carbamoyl group, an alkylcarbamoyl group, an acyl group or a carboxy group; R<2> is a hydrogen atom or a lower alkyl group; R<3> is a hydrogen atom, a lower alkyl group or an aralkyl group; R<4> is a hydrogen atom, a halogen atom, a lower alkyl group, a hydroxy group, an alkoxy group, an acyl group, an alkoxycarbonyl group, a nitro group, an amino group, a substituted amino gropup, a carbamoyl group, an alkylcarbamoyl group or an acyloxy group; R<5> is a lower alkyl group, a cyano group, a carbamoyl group, a carboxy group, an acyl group, an acyloxy group, an alkoxy group, an alkoxycarbonyl group, a trihalomethyl group or a hydroxy group; and n is an integer of 2 to 6.Ü
Patent DE-69733948-D1 (DE)
Inventor: PERRICAUDET MICHEL
IPC: C12N15/86
Filed: 1997-05-23
Granted: 2005-09-15
Abstract: The invention discloses circular and replicating DNA molecules, useful in gene therapy, as well as a particularly efficient method for generating them in situ from a viral vector.
Patent DE-69735935-D1 (DE)
Inventor: THATCHER ROBERT
IPC: C12N15/10
Filed: 1997-02-12
Granted: 2006-06-29
Abstract: A scalable method for the production of highly purified plasmid DNA in Escherichia coli is described, which method includes growing plasmid-containing cells to a high biomass in exponential growth and lysing the cells by raising the pH of the culture to a carefully controlled pH value in which chromosomal DNA is denatured but plasmid DNA is reversibly renatured. The method has been developed for the production of pharmaceutical grade DNA for use in in vivo and ex vivo gene therapy.
Patent DE-69738579-D1 (DE)
Inventor: GOTO HARUYOSHI
IPC: C08F2/06
Filed: 1997-12-23
Granted: 2008-04-30
Abstract: There is disclosed a method of producing a copolymer by polymerizing at least two monomers having different reactivity as constitutional components, comprising carrying out a polymerization while adding a monomer component B having high reactivity, to a solution of a monomer component A having low reactivity dissolved in a non-aqueous solvent having a boiling point of 55  DEG C to 120  DEG C, in the presence of a polymerization initiator. The method can give a copolymer high in solubility and suitable for the processing by the flush vacuum dry system, and the method is excellent from the standpoint of the production capacity and stable/safe production throughout the process.
Patent DE-69739760-D1 (DE)
Inventor: WYNICK DAVID
IPC: G01N33/50
Filed: 1997-07-24
Granted: 2010-03-25
Abstract: This invention relates to galanin and its uses. In particular, the invention provides a knockout mouse which lacks a functional galanin gene. The mouse may be used to investigate the effects of galanin. <??>It has also been unexpectedly discovered that galanin antagonists may be used in the management of pain, particularly painful neuropathies, the supression of pain, in the supression of location, in the treatment of prolactinoma and in anaesthesia. Additionally, the use of galanin agonists may be used in the treatment of Alzheimer's disease, in improving memory and cognition and in the treatment of nerve damage, such as the promotion of nerve regeneration.
Patent DE-69806159-D1 (DE)
Inventor: HODGKINSON WILLIAM
IPC: B08B6/00
Filed: 1998-07-17
Granted: 2002-07-25
Abstract: Apparatus for cleaning and delivering cans to a can filling machine comprises a track 10 for the cans, air from the air blower 16 for conveying cans along the track, an ionisation source 20 for introducing ionised air into the cans and a vacuum chamber and pump 24 for extracting air from the cans
Patent DE-69819793-D1 (DE)
Inventor: MERIAUDEAU PAUL
IPC: B01J29/035
Filed: 1998-02-17
Granted: 2003-12-24
Abstract: New catalytic compositions for the dehydrogenation of alkanes to alkenes and H2, which comprise a non-acidic microporous silicalite support, a Pt metal, a Ge-based compound and a compound based on Sn or In. In the silicalite network, ther is no substitution of Si by Ge. Also claimed is the preparation of the compositions. Preferably the content of Pt metal is 0.01-5% (more preferably 0.01-2%), and the content of Ge is 0.01-5% (more preferably 0.01-2%). The Sn or In content is 0.01-10% (more preferably 0.01-2%).
Patent DE-69827051-D1 (DE)
Inventor: SAKAGUCHI KIYOFUMI
IPC: H01L21/304
Filed: 1998-02-03
Granted: 2004-11-25
Abstract: A wafer is supported while being rotated by four wafer rotating rods having grooves. The wafer rotating rods are rotated by a driving force transmitted from a motor installed outside a wafer processing bath. An ultrasonic bath is arranged below the wafer processing bath, and ultrasonic waves generated by an ultrasonic source are transmitted to the wafer processing bath. The ultrasonic waves are efficiently transmitted to the wafer because the wafer is supported only by the wafer rotating rods. <IMAGE>
Patent DE-69828035-D1 (DE)
Inventor: SCHABERT GUENTER
IPC: C12Q1/34
Filed: 1998-02-26
Granted: 2005-01-13
Abstract: A method of detecting a phosphatidylinositol-specific phospholipase C enzyme by means of a substrate which is cleaved by said enzyme and yields a dye when the chromophoric portion of the substrate is dimerized and oxidized; the invention teaches using in such method, as a novel substrate, a 3-indoxyl-myoinositol-1-phosphate compound of formula (I) wherein R is selected from the group consisting of hydrogen and C1-4 alkyl, while R1, R2, R3, and R4 are radicals selected from the group consisting of hydrogen and chromogenic substituents, or of a salt of said formula I compound. The invention provides for a safe, sensitive and commercially viable detection of potentially pathogenic bacterial activity of such microbes as Bacillus cereus, B. Thuringiensis, Staphylococcus aureus and various Listeria strains in potentially infected materials including physiological samples or consumable goods such as foods and beverages.
Patent DE-69835368-D1 (DE)
Inventor: ROBERTSON ANNE
IPC: A61K38/22
Filed: 1998-03-06
Granted: 2006-09-07
Abstract: A method of treating an infertility condition in humans or mammals, by exposure of a prospective mother to TGF² or derivative or analog of TGF². The exposure is advantageously in conjunction with one or more antigens of a prospective father so that a hyporesponsive immune reaction is mounted to the one or more antigens of the prospective father.
Patent DE-69908085-D1 (DE)
Inventor: NANOS J
IPC: G06Q30/02
Filed: 1999-01-05
Granted: 2003-06-26
Abstract: An automated survey kiosk which is easy to install at a location, does not require access to standard telephone lines, can be easily reprogrammed, has unlimited language capabilities, which permits open-ended answers to inquiries or questions and whose survey responses can be sent directly to a client. The automated survey kiosk for administering a survey includes a touch screen for displaying the survey and for receiving survey responses, the touch screen being operatively connected to a general purpose computer for storing the survey, the general computer including a memory for storing the survey responses, operatively connected to the touch screen; and a wireless modem for transmitting the survey responses at a remote location at predetermined intervals. The automated survey kiosk is programmed to prompt a user for a desired language and then administer the survey in the chosen language. The automated survey kiosk may be remotely reprogrammed with new questions, by altering existing questions or by deleting existing questions, from the location of the research firm, even while a respondent is answering the survey. The survey responses may be transmitted to the research firm, or may be directly sent to the client, who must be equipped with the proper equipment to communicate with the automated survey kiosk. Accordingly, the client can have almost instantaneous access to the latest survey data, and can modify the survey during the survey period. The kiosk is also provided with a microphone in order to permit a respondent to record a verbal answer should the multiple choices offered not adequately described the respondent's answer.
Patent DE-69912299-D1 (DE)
Inventor: HAKIM NOURI E
IPC: A47G21/04
Filed: 1999-08-24
Granted: 2003-11-27
Abstract: A method for feeding a baby using a combination food utensil constructed of materials having different relative hardness, and particularly a spoon. Portions of the spoon are constructed of a hard material such as polypropylene to provide structural rigidity and to allow the utensil to easily slide along the bottom of a dish such as bowl or a plate. Other portions of the spoon are constructed of a softer material such as Kraton or silicone to provide for comfortable contact with the inside of the mouth and gums.
Patent DE-69913446-D1 (DE)
Inventor: REUS BRIGITTE
IPC: E04B1/343
Filed: 1999-07-30
Granted: 2004-01-22
Abstract: A residential building (9) with an adjacent open-air swimming pool (3) that is built in the ground has a pair of guide rails (7, 7') that allow the building to be moved by means of rollers or sliders so that it covers the swimming pool during the winter. During the summer the pool is used as an open-air pool, while in the winter the building is pushed or pulled so that it is located over the pool, with access to it through a removable floor panel (9). The building has detachable or flexible electricity, water and drainage connections.
Patent DE-69914796-D1 (DE)
Inventor: FRIES ROBERT
IPC: B23B27/14
Filed: 1999-10-08
Granted: 2004-03-18
Abstract: A tool component comprising an abrasive element presenting a cutting edge or point and a thermally conductive element having a thermal conductivity greater than the thermal conductivity of the abrasive element, wherein the thermally conductive element is in thermal contact with the abrasive element so as to conduct heat generated at the cutting edge or point away from such cutting edge or point. The thermally conductive element may be bonded to a substrate. The abrasive element may be PCBN and the thermally conductive element may be either CVD diamond or PCD or else the abrasive element may be PCD and the thermally conductive element may be CVD diamond.
Patent DE-69923300-D1 (DE)
Inventor: ICHIMORI YUZO
IPC: A61K31/18
Filed: 1999-03-08
Granted: 2005-02-24
Abstract: The present invention provides a prodrug of a compound represented by the formula: <CHEM> wherein R represents an aliphatic hydrocarbon group optionally having substituents, an aromatic hydrocarbon group optionally having substituents, a heterocyclic group optionally having substituents, a group represented by the formula: OR<1> (wherein R<1> represents a hydrogen atom or an aliphatic hydrocarbon group optionally having substituents) or a group represented by the formula: <CHEM> wherein R<1b> represents a hydrogen atom or an aliphatic hydrocarbon group optionally having substituents, R<1c> is, same with or different from R<1b>, a hydrogen atom or an aliphatic hydrocarbon group optionally having substituents, R<0> represents a hydrogen atom or an aliphatic hydrocarbon group, or R and R<0> represents a bond with each other, Ar represents an aromatic hydrocarbon group optionally having substituents, <CHEM> and n is an integer of 1 to 4, or a salt thereof, which is a agent for preventing or treating diseases such as cardiac disease, autoimmune disease, septick shock, etc..