baber/WOPTO huggingface dataset:
Patent CA-2442168-A1 (CA)
Inventor: HERZENBERG LEONARD A
IPC: A61P43/00
Filed: 2002-03-28
Abstract: The invention provides pharmaceutical compositions for the treatment or prevention of the toxic effects of therapeutic agents and methods of treating or preventing such toxicity using a toxicity reducing amount of N- acetylcysteine either alone or in combination with a therapeutically effective amount or, to achieve its therapeutic advantages, an amount larger than what is customarily given as a therapeutically effective amount, of a therapeutic agent. The invention also provides pharmaceutical compositions for the treatment or prevention of the toxic effects of therapeutic agents and methods of treating or preventing such toxicity using a toxicity reducing amount of N- acetylcysteine either alone or in combination with a therapeutically effective amount or, to achieve its therapeutic advantages, an amount larger than what is customarily given as a therapeutically effective amount, of a therapeutic agent whose side effects are made worse by increased oxidative stress or treatment related decreases in subject cysteine/glutathione levels or are otherwise relieved by administration of NAC.
Patent CA-2442904-A1 (CA)
Title: Benzamidine derivative
Inventor: SHIMADA IKUKO
IPC: A61P7/02
Filed: 2002-04-03
Abstract: A benzamidine derivative having the general formula: (1) wherein R1 represents a hydrogen atom, a halogen atom, an alkyl group or a hydroxyl group, R2 represents a hydrogen atom or a halogen atom, R3 represents a hydrogen atom, an alkyl group optionally substituted, an aralkyl group, an alkylcarbonyl group optionally substituted, an alkylsulfonyl group optionally substituted, or the like, R4 and R5 each represent a hydrogen atom, a halogen atom, an alkyl or carbamoyl group optionally substituted, or the like, R6 represents a heteroring or the like, R7 and R8 each represent a hydrogen atom, an alkyl group, or the like, and n represents 0,1 or 2; or a salt thereof being pharmacologically acceptable. The benzamidine derivative and the salt have excellent inhibition action for activated blood coagulation factor X, and are useful as a medicine for therapy or prevention of a disease of blood coagulation.
Patent CA-2444913-A1 (CA)
Inventor: ROCKLAGE BERNARD
IPC: A23G3/40
Filed: 2003-10-15
Abstract: A process for preparing fat - containing confectionery material by injection of a fat-containing mass between two separable mold surfaces defining a closed cavity, which comprises: .cndot. tempering fat-containing confectionery, .cndot. introducing the fat - containing confectionery at a temperature in the range of about 25° to 34°C under a pressure gauge of 1 to 100 bars into a cavity between separable molds surfaces, having a temperature in the range of about 5°C higher to 5°C lower than the temperature of the fat-containing mass, .cndot. keeping the fat-containing confectionery in contact with the mold and cooling of the mold until the surface of the fat-containing confectionery has reached a surface temperature of about 17°C or less, and .cndot. separating the mold surface and removing the fat-containing confectionery. The invention relates furthermore to fat-containing confectionery products comprising .cndot. similarly or differently structured upper and lower sides .cndot. a shiny appearance on both sides .cndot. same surface characteristics on both sides.
Patent CA-2445363-A1 (CA)
Title: Semi-permeable microcapsule with covalently linked layers and method for producing same
Inventor: LEBLOND FRANCOIS
IPC: A61K35/39
Filed: 2003-10-17
Abstract: The present invention relates to semi-permeable microcapsules, which exhibit an increased resistance to mechanical stresses as well as an increased resistance to chemical degradation. More specifically, this semi-permeable microcapsule has a bead enclosing a material such as living cells, covalently linked to a semi-permeable layer, made of a polycation cross-linking derivative, covering the bead. The present invention is also directed to a pharmaceutical composition comprising the above-mentioned semi-permeable microcapsules. The present invention is also directed to the use of such microcapsule in a method for microencapsulating a beaded material and in a method for treating diabetes in a subject.
Patent CA-2445485-A1 (CA)
Inventor: MICHALEC JOSEPH
IPC: C09D7/45
Filed: 2002-07-23
Abstract: The present invention is directed to a polymeric pigment dispersant to be used as a grind resin to incorporate pigment into a pigment dispersion for a coating composition. The polymeric pigment dispersant is the reaction product of dipentaerythritol, hexahydrophthalic anhydride, glycidylneodecanoate, dimethylethanolamine, and polyphosphoric acid. The present invention is also directed to a method of preparing the polymeric pigment dispersant. In this method, the dipentaerythritol and the hexahydrophthalic anhydride are polymerized to form an intermediate compound. Next, an epoxy group of the glycidylneodecanoate reacts with the intermediate compound, and then the dimethylethanolamine salts the intermediate compound. Finally, the polyphosphoric acid is added to form the completed polymeric pigment dispersant. The polymeric pigment dispersant has improved stability in the pigment dispersion and is utilized for efficient wetting and grinding of the pigment in the pigment dispersion.
Patent CA-2446346-A1 (CA)
Title: Thermal coating materials and coating materials that can be cured thermally and using actinic radiation and the use thereof
Inventor: MEISENBURG UWE
IPC: C09D7/61
Filed: 2002-08-10
Abstract: The invention relates to thermal coating materials and to coating materials that can be cured thermally and using actinic radiation. Said materials contain: (A) a binding agent from the group of polyaddition resins, polycondensation resins and copolymers of olefinically unsaturated monomers that can be physically or thermally cured, cured using actinic radiation or cured thermally and using actinic radiation and that have a stochastic, alternating, block-type structure, or are linear or branched and have a comb-type structure; and (B) nanoparticles, which have been modified by a compound (I): [(S-)o-L-]n-M-(-X-R)m-n, in which the indices and variables are defined as follows: S represents a reactive, functional group comprising a bond that can be activated by actinic radiation; L represents a bivalent, organic linking group; X represents an oxygen atom, sulphur atom or >NR1, wherein R1 =  a hydrogen atom or an alkyl group; M represents a metal atom; R represents a monovalent, organic group; o represents 1 to 5; m represents 3 or 4; n stands for m = 3, 1 or 2 and n for m = 4, 1, 2 or 3. The invention also relates to the use of said materials for producing clear lacquers and coloured and/or decorative-effect multi-layer lacquers or as adhesives and sealants.
Patent CA-2447853-A1 (CA)
Title: Chemical reaction apparatus and power supply system
Inventor: TAKEYAMA KEISHI
IPC: H01M8/06
Filed: 2003-03-19
Abstract: A chemical reaction apparatus includes a solid body which has an outer surface, and in which at least one flow path which allows a chemical medium to flow is formed. This body has a heating element which heats the chemical medium in the flow path to accelerate a chemical reaction of the chemical medium, and a heat radiation preventing film which covers at least a portion of the outer surface of the body, and prevents radiation of heat generated by the heating element from a portion of the outer surface.
Patent CA-2449542-A1 (CA)
Inventor: HURTIS PAUL
IPC: A01B29/04
Filed: 2003-11-17
Abstract: There is disclosed a primary tillage system in combination with a soil conditioner rotary reel that addresses the performance requirement differences due to soil types and moisture conditions that other tillage systems do not address. The combination provides a one-pass seedbed preparation process of a superior quality to that of any heretofore known one-pass systems through the improved performance of the soil conditioning rotary reel. The rotary reel includes a plurality of flat bars attached to support plates in a symmetrical helix arrangement that provide a thorough breakup of clods not heretofore possible.
Patent CA-2451187-A1 (CA)
Inventor: MEADOR STACEY
IPC: A61F2/02
Filed: 2002-06-20
Abstract: A coaxial implant has been developed using entirely biodegradable polymeric materials. As referred to herein, a coaxial implant is a device having a cor e containing drug, surrounded by a semi-permeable membrane that controls the rate of release from the core. The device is formed by extrusion, using a pr e- milling and extruding step to maximize uniformity of drug dispersion within the polymeric material. In one embodiment, the polymer is processed to yield a semi-crystalline polymer, rather than an amorphous polymer. The core containing the drug and the polymer membrane(s) can be the same or different polymer. The polymer can be the same or different composition (i.e., both polycaprolactone, or both poly(lactide-co-glycolide) of different monomer ratios, or polycaprolactone outside of a core of poly(lactide)), of the same or different molecular weights, and of the same or different chemical structure (i.e., crystalline, semi-crystalline or amorphous). The core acts as a reservoir of drug, which partitions from the core polymer to form a saturated solution of at least 10% drug at the polymer membrane.
Patent CA-2452795-A1 (CA)
Inventor: OLIVE PETER JAMES WILLIAM
IPC: A01K67/033
Filed: 2002-07-01
Abstract: The present invention provides a method for the aquaculture of marine deposi t feeders, such as Arenicola marina and Arenicola defodiens. The method comprises providing a foodstuff such as brewery yeast or waste from fish far ms within the substrate housing the worms. The foodstuff is conveniently particulate or microparticulate to aid intimate admixture with a substrate, which is typically sand.
Patent CA-2453930-A1 (CA)
Title: Catheter with injection needle
Inventor: PONZI DEAN
IPC: A61B18/14
Filed: 2003-12-22
Abstract: An injection catheter is provided. The catheter comprises a catheter body comprising a flexible tubing having proximal and distal ends and at least one lumen therethrough. The catheter further comprises a tip section comprising a flexible tubing having proximal and distal ends. The proximal end of the tip section is mounted at the distal end of the catheter body. A needle control handle is provided at the proximal end of the catheter body. An injection needle extends through the tip section, catheter body, and needle control handle and has a proximal end attached to the needle control handle and a distal end within the tip section.  The injection needle is longitudinally slidable within the tip section so that its distal end can extend beyond the distal end of the tip section upon suitable manipulation of the needle control handle. The injection needle consists of plastic.
Patent CA-2456404-A1 (CA)
Title: Device for measuring and/or checking the distance between a shearbar and a chopping knife
Inventor: CLAUSS STEFFEN
IPC: A01D43/08
Filed: 2004-01-29
Abstract: A crop chopping arrangement for a forage harvester includes a shearbar mounted adjacent a path swept by chopping knives of a chopper drum and being selectively adjustable toward and away from said path so as to adjust the distance between the shearbar and knives as they pass by the shearbar. An arrangement for measuring and/or checking the distance between the shearbar and the knives includes a vibration sensor located to measure the mechanical vibrations in the shearbar produced by the moving knives, and an electronic evaluation circuit. The evaluation circuit is operable for performing a frequency analysis of the signal provided by the vibration sensor so as to derive information indicative of the distance between the shearbar and knives.
Patent CA-2456664-A1 (CA)
Inventor: ROLLAIN BRUNO
IPC: G09F3/00
Filed: 2002-08-02
Abstract: The invention concerns a label with multiple data designed to be affixed by adhesive on the outer wall of a container, receptacle or the like (8), containing a particular product, consisting of at least two superimposed leaflet (1, 2) each bearing data on at least one of the surfaces, the rear leaflet (2) being adapted to be fixed through its entire surface against said receiving wall. The invention is characterised in that the front leaflet (1) has a first edge arranged such that the front (1) and rear (2) leaflets are, when the label is fixed, pressed one against the other and the front leaflet (1) has at least a tear strip (7).
Patent CA-2459948-A1 (CA)
Title: Security system user interface with video display
Inventor: HERSHKOVITZ SHMUEL
IPC: G06F19/00
Filed: 2004-03-05
Abstract: A security system user interface comprising a graphical display, a communication link, a memory, a camera and a display controller. The camera image is converted for display on the graphical display, the latter being used for security system control and viewing the camera image. The interface is best located near an entrance inside a secured premises, while the camera is arranged to monitor visitors outside the secured premises at the entrance. The camera can be connected directly to the user interface or indirectly using a data communications link of the security system interconnecting security detectors to a control panel.
Patent CA-2460320-A1 (CA)
Inventor: LUTNICK HOWARD W
IPC: G06Q30/06
Filed: 2004-03-05
Abstract: The present invention relates to systems and methods for implementing an automated auction process that is held at a designated time on the Internet, and that ends after bidding has been completed. In accordance with triese systems and methods, a server connected to a plurality of workstations may establish several auctions that allow for efficient trading of multiple goods, while simulating the live and dynamic setting of traditional auctions.
Patent CA-2460408-A1 (CA)
Inventor: KORENGEL JEFFREY L
IPC: A23N1/00
Filed: 2001-09-14
Abstract: An extractor for separating the juice and juice sacs from a citrus fruit tha t includes a lower cup (16) for supporting a single piece of citrus fruit and an upper cup (14) disposed vertically above the lower cup with the upper and lower cups moveable relative to each other in a vertical direction so as to cooperate to squeeze the piece of citrus fruit placed therebetween. An upper cutter (30) is provided for cutting a plug in the citrus to permit the separation of the peel from the juice and the juice sacs, while a lower cutt er (24) is provided for cutting the plug to allow the juice and juice sacs to exit therethrough when the fruit is squeezed between the upper and lower cup s. A strainer tube (26) is vertically oriented beneath the lower cup and lower cutter, with the strainer tube having a plurality of circumferential slots (38) along its working length (36). A plunger tube is slidingly received within the strainer tube for forcing the juice and juice sacs outwardly through the slots and the strainer tube into a separate reservoir. The slots in the strainer tube may be of equal width and evenly spaced apart or of varying widths. In any event, the slots are preferably between about 0.5 and about 3 millimeters in width.
Patent CA-2463248-A1 (CA)
Title: Gaming machine with interactive pop-up windows
Inventor: CASEY MICHAEL P
IPC: G07F17/32
Filed: 2004-04-05
Abstract: A gaming machine includes interactive pop-up windows that provide a player with an opportunity to configure or view different aspects of a wagering game.  For example, the windows may allow the player to make side bets on a selected symbol, modify the appearance or function of a selected symbol, view a pay history for a selected symbol, and/or adjust a wager on an individual pay tine in the case of a reel slot game.
Patent CA-2467497-A1 (CA)
Title: Control information between base and mobile stations
Inventor: CHOI HO-KYU
IPC: H04L12/70
Filed: 2002-11-30
Abstract: An apparatus and method for transmitting and receiving a PDCCH for efficient transmission of a PDCH in a communication system supporting a packet data service. PDCCHs according to the present invention enable TDM and TDM/CDM  transmission of the PDCH, Especially, CRC generators and CRC checker of the present invention allow a second user to utilize control information on a first PDCCH.
Patent CA-2471119-A1 (CA)
Inventor: STEWART A KEITH
IPC: C12N15/55
Filed: 2002-12-23
Abstract: Lipase proteins play important role in tissue or plasma lipid and lipoprotei n metabolism and function to hydrolize lipid such as triglycerides. Disease associates with lipase function indludes lipase deficiency, atherosclerosis, fatty liver disease and dyslipidemias, such as hypercholesterolemia, hypertriglyceridemia, mixed (combined) dyslipidemia, lipid or lipoprotein deficient states, and/or any other tissue or plasma disorders of lipid or lipoprotein metabolism. The invention describes two novel lipase proteins (LPDL and LPDLR) and the nucleic acids encoding them as well as the regulato ry sequences controlling their gene expression. The invention relates to use of LPDL and/or LPDLR nucleic acid or their proteins in modulating cellular process in disease state or in normal energy homeostasis. The invention also relate to their modulators, antibodies, antisense oligonucleotides and diagnostic assays, the screening for mutations, gene therapy, use of their promoters to control gene expression, and their industrial use in food industry and oil and waste management. The invention also relates methods of drug screening for LPDL and LPDLR, their therapeutic use in humans and their use as pharmaceutical compositions.
Patent CA-2475272-A1 (CA)
Title: Lubricating coating and application process for elastomeric electrical cable accessories
Inventor: BOLCAR JOHN PAUL
IPC: B29K21/00
Filed: 2003-04-10
Abstract: This invention relates to a method for coating an elastomeric component with a coating that has a low coefficient of friction and the articles formed by the method. The method includes preparing an elastomeric coating (10); applying the coating (10) to a substrate; contacting the coated substrate with an elastomeric compound; and heating the elastomeric compound and the coated substrate under pressure to bond the coating (10) to the elastomeric compound and form a coated elastomeric component (14).
Patent CA-2475929-A1 (CA)
Title: Sequences de signaux eukaryotes pour l'expression de polypeptides et bibliotheques de presentation de polypeptides
Inventor: VEERAMALLU UDAY KUMAR
IPC: C12N15/09
Filed: 2003-02-13
Abstract: De manière générale, la présente invention a trait à des procédés et des compositions permettant l'expression de protéines ou de polypeptides dans des hôtes procaryotes utilisant des séquences de signaux eukaryotes.
Patent CA-2477493-A1 (CA)
Title: Transition metal chelates as selective herbicides
Inventor: ALMOND DAVID S
IPC: A01N43/58
Filed: 2003-02-28
Abstract: An environmentally safe selective herbicide is provided that includes at least one metal component and at least one chelating agent. The metal component can have a variety of forms, but is preferably in the form of a metal salt, a metal chelate, or combinations thereof. The chelating agent can also have a variety of forms, but is preferably in the form of a metal chelate, a salt, an acid, or combinations thereof. Methods of use are also provided.
Patent CA-2484175-A1 (CA)
Inventor: BERGET JOHN ARVE
IPC: B63B35/26
Filed: 2003-04-25
Abstract: Towboat of the kind that has a towing point (22, 23), such as a towing hook placed in such way that a towline can move freely to both sides. The deck house (27) of the towboat and additional superstructure are placed in front of the towing point (22, 23). It has at least one hold (11) for transportation and/or treatment of fish, which hold extends in both longitudinal directions from the midship area of the vessel. This hold (11) is arranged for rapid intake and outlet of water from the sea, for intake of sea water for circulation, and/or for increasing stability, for enhancing the possible towing force.
Patent CA-2484382-A1 (CA)
Inventor: LEONARD GLENDA ANN
IPC: G06F16/21
Filed: 2004-10-08
Abstract: A method for defining and constraining the behavior of a shared, mobile content management system is disclosed. The method includes providing an admin conso le for defining, modifying, and managing declarative policies. Declarative policies are defined based on an XML policy model. The XML policy model dictates the policies tha t can be expressed by the admin console. The defined declarative policies are enacted without requiring the content management system to be restarted, reconfigured, or re - implemented. An XML-based policy wizard definition language is provided to define policy wizards in the admin console that guide an administrator through the steps of creating and editing the policies. Additionally, at least one policy repository based on LDAP is provided. The at least one policy repository has an interface and is adapted to store a plurality of declarative policies. The policy repository has scalabl e and distributed capabilities.
Patent CA-2485142-A1 (CA)
Inventor: NARIMATSU HISASHI
IPC: C12Q1/68
Filed: 2003-03-14
Abstract: An enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Gal.beta.1-4Glc or Gal.beta.1-4GlcNAc-group via a .beta.-1,3 bond; a nucleic acid encoding the same; and a method of diagnosing cancer and/or tumor, in particular, digestive cancer and/or tumor using the expression dose of a gene of the above enzyme as an indication. A gene of a novel enzyme having an activity of transferring N-acetylglucosamine to the non-reducing end of a Gal.beta.1-4Glc or Gal.beta.1-4GlcNAc-group via a .beta.-1,3 bond is cloned from human stomach cells and its base sequence is determined.  Then this enzyme is expressed. Since this enzyme is scarcely or never produced in cancer and/or tumor, in particular, digestive cancer and/or tumor cells, cancer and/or tumor can be diagnosed with the use of the expression of the enzyme gene as an indication.
Patent CA-2485732-A1 (CA)
Title: Generation and selection of protein library in silico
Inventor: LIU SHENGJIANG
IPC: G16B35/20
Filed: 2003-05-20
Abstract: The present invention provides a methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as improved binding affinity towards biologically and/or therapeutically important target molecules. The process is carried out computationally in a high throughput manner by mining the ever-expanding databases of protein sequences of all organisms, especially human. In one embodiment, a method for constructing a library of designed proteins, comprising the steps of: providing an amino acid sequence derived from a lead protein, the amino acid sequence being designated as a lead sequence;  comparing the lead sequence with a plurality of tester protein sequences; and selecting from the plurality of tester protein sequences at least two peptide segments that have at least 15% sequence identity with the lead sequence, the selected peptide segments forming a hit library; and forming a library of designed proteins by substituting the lead sequence with the hit library. The library of designed proteins can be expressed in vitro or in vivo to produce a library of recombinant proteins that can be screened for novel or improved function(s) over the lead protein, such as an antibody against therapeutically important target.
Patent CA-2486045-A1 (CA)
Title: Microprocessor controlled time domain switching of color-changing lights
Inventor: MURPHY KEVIN
IPC: H05B37/02
Filed: 2004-10-26
Abstract: A lighting system controller comprising a switch connected to a lighting fixture configured to be controlled by time domain switching, and a processor capable of actuating said switch so as to achieve time domain switching of the lighting fixture.