baber/WOPTO huggingface dataset:
Patent EP-4153745-A1 (EP)
Title: Viral vectors and nucleic acids for regulated gene therapy
Inventor: PARK JOHN
IPC: C12N15/113
Filed: 2021-05-17
Abstract: This invention generally relates to the field of somatic gene therapy. The invention provides a nucleic acid construct comprising a transgene encoding a therapeutic protein, a tetracycline-responsive aptazyme sequence, and inverted terminal repeats (ITRs). The nucleic acid construct can be transferred to a subject in need thereof in the form of a viral vector, in particular an adeno-associated virus (AAV) vector. The Tet-responsive aptazyme sequence allows for a tightly controlled expression of the transgene in the subject, thereby avoiding toxic side effects. The nucleic acid construct and the viral vectors comprising same are particularly useful in the treatment of proliferative diseases like cancer.
Patent EP-4142633-A1 (EP)
Inventor: KOENIG MATTHEW W
IPC: A61B34/20
Filed: 2021-04-27
Abstract: Disclosed is a system to assist in a procedure. During the procedure an object may be moved relative to a subject, such as being positioned and/or placed within a subject. The system and related method may be used to assist in displaying and/or determining a pose of the object relative to a subject, such as rigid portions of a subject. The system comprises a processor system configured to execute instructions to: access an image data of a subject having at least a first portion and a second portion of the subject; analyze a region of interest (ROI) between the first portion and the second portion; determine a ROI geometry of the region of interest; access a model of an object, the model including at least (i) a dimension of a rigid portion of the object and (ii) a plurality of possible configurations of a configurable portion of the object; and analyze the accessed model to determine an optimal fit of the object to achieve the ROI geometry; and output a result of the analysis of the accessed model.
Patent EP-4041785-A1 (EP)
Title: Optical grade moulding compositions having increased thermal stability
Inventor: CARLOFF RÜDIGER
IPC: C08F220/14
Filed: 2021-06-23
Abstract: The present invention relates to a copolymer having increased heat resistance, high transparency and low haze values. The invention further relates to moulding compositions comprising this copolymer and to a process for the manufacturing this copolymer. The moulding compositions of the present invention are highly suitable for the manufacturing of optical elements used in various optical devices including primary optics, secondary optics, tertiary optics as well as light guides.
Patent EP-4179530-A1 (EP)
Title: Comfort noise generation for multi-mode spatial audio coding
Inventor: JANSSON TOFTGÅRD TOMAS
IPC: G10L19/012
Filed: 2021-07-06
Abstract: A method for generating comfort noise is provided. The method includes providing a first set of background noise parameters N1 for at least one audio signal in a first spatial audio coding mode and a second set of background noise parameters N2 for the at least one audio signal in a second spatial audio coding mode. The first spatial audio coding mode is used for active segments; the second spatial audio coding mode is used for inactive segments. The method further includes adapting the first set of background noise parameters N1 to the second spatial audio coding mode, thereby providing a first set of adapted background noise parameters N̂1. The method further includes generating comfort noise parameters by combining N̂1 and N2 over a transition period. The method further includes generating comfort noise based on the comfort noise parameters.
Patent EP-4093883-A1 (EP)
Inventor: HUYGENS FLAVIA
IPC: C12Q1/689
Filed: 2021-01-22
Abstract: The present invention relates to methods and agents for determining the quantity or concentration of a bacterium in a sample. The method may include the steps of: (a) amplifying a target nucleic acid of the bacterium from genetic material obtained from the sample to form an amplification product, wherein the target nucleic acid comprises at least a portion of a bacterial 16S rRNA gene; (b) measuring a quantity or concentration of the amplification product; (c) calculating a quantity or concentration of the target nucleic acid in the sample by comparing the quantity or concentration of the amplification product with a reference level thereof; and (d) determining a copy number of the bacterial 16S rRNA gene in the sample from the quantity or concentration of the target nucleic acid therein, the copy number being a function of or correlated to the quantity of the bacterium in the sample. In other embodiments, the invention relates to methods of determining a prognosis for an infection by a bacterium in a subject, to methods of treating an infection or of evaluating treatment efficacy of an infection by a bacterium and to kits and assays.
Patent EP-4196425-A1 (EP)
Title: Method and system for providing an improved all-terrain telehandler
Inventor: OURADA TIM
IPC: B66F9/065
Filed: 2021-07-08
Abstract: An all-terrain telehandler includes a pair of front tracks. Each front track may be coupled to a front bracket by an arm that telescopes relative to the front bracket. A superstructure may be coupled to the front bracket where the superstructure supports a first telescoping boom. A pair of rear tracks may be coupled to a rear body. The rear body may be coupled to the front superstructure. A maximum extension position for the first telescoping boom and a length generally corresponding to a length of the superstructure may define a ratio of approximately 4.00:1.00, whereby the all-terrain telehandler is substantially stable when moving loads supported by the first telescoping boom. A second telescoping boom may support a cab. With the second boom, the cab may be lowered beneath a top section of one of the front tracks for facilitating an operator loading sequence.
Patent EP-4196683-A1 (EP)
Inventor: SMITH PAUL DAVID
IPC: F04C18/30
Filed: 2021-08-05
Abstract: A pump for pumping a gas, the pump comprising: a rotor and a stator; the rotor at least one liquid opening configured for fluid communication with a liquid source. The liquid opening is configured such that in response to a driving force a stream of liquid is output from the opening. The stream of liquid form a liquid blade between the rotor and the stator, gas confined by the stator, the rotor and the liquid blade being driven through the pump along a pumping channel from a gas inlet towards a gas outlet in response to relative rotational motion of the rotor and the stator. The pump is configured such that the pumping channel comprises side walls that slope towards each other from the rotor that comprises the liquid opening towards a further wall of the pumping channel remote from the rotor, such that a distance between the side walls decreases with increasing distance from the liquid opening, a tangent to a mid point of the side walls having an angle of between 5º and 40º with respect to a line perpendicular to an axis of rotation of the rotor.
Patent EP-4196346-A1 (EP)
Inventor: ABUL KASHEM MOTTAKIN
IPC: B32B27/08
Filed: 2021-08-12
Abstract: The invention concerns a multi-layered polyethylene film comprising at least an outer layer, a core layer, and a seal layer, in that order, wherein the seal layer comprises: i) at least 30.0 wt.% of a first multimodal linear low density polyethylene terpolymer, relative to the total weight of the seal layer; and ii) at least 10.0 wt% of a first plastomer, relative to the total weight of the seal layer, having a density of 910 kg/m 3  or less (ISO1183); wherein the core layer comprises: a) at least 8.0 wt% of second plastomer, relative to the total weight of the core layer, having a density of 910 kg/m 3  or less (ISO 1183), or b) at least 8.0 wt% of a multimodal linear low density polyethylene (LLDPE) binary copolymer relative to the total weight of the seal layer; and c) a second multimodal polyethylene terpolymer.
Patent EP-4196370-A1 (EP)
Inventor: TENKAP MFOUBI OLIVIER FRANK
IPC: B60R21/015
Filed: 2021-07-27
Abstract: Die Erfindung betrifft eine Seitenairbagvorrichtung (12) für ein Kraftfahrzeug (10) mit zumindest einem Gassack (14), in welchem bei einem Aufprall ein Gas mittels eines Gasgenerators (16) der Seitenairbagvorrichtung (12) eingebracht wird, und mit einem Ablassventil (18, 20) zum Entlüften von dem Gas unmittelbar nach dem Aufprall, wobei die Seitenairbagvorrichtung (12) eine elektronische Recheneinrichtung (22) und ein weiteres Ablassventil (24) und/oder einen weiteren Gasgenerator aufweist, wobei mittels einer Erfassungseinrichtung (26) der Seitenairbagvorrichtung (12) ein Insasse (28) des Kraftfahrzeugs (10) erfasst wird, wobei die Seitenairbagvorrichtung (12) zum Schutz dieses Insassen (28) bei dem Aufprall mit dem Gas befüllt wird, und die elektronische Recheneinrichtung (22) dazu ausgebildet ist, in Abhängigkeit von dem erfassten Insassen (28) einen Gasdruck im Gassack (14) durch Ansteuern des weiteren Ablassventils (24) und/oder des weiteren Gasgenerators vor dem Aufprall zu bestimmen und den Gasdruck bei dem Aufprall an den Insassen (28) anzupassen. Ferner betrifft die Erfindung ein Verfahren.
Patent EP-4113753-A1 (EP)
Inventor: ZHANG MIAO
IPC: H01R13/506
Filed: 2021-02-10
Abstract: A fixing holder of a modular insertion core (2), the fixing holder used for receiving similar and/or different modular insertion cores (2), wherein the fixing holder comprising: a first frame body (1) provided therein with a cavity where the modular insertion core (2) is accommodated. The modular insertion core (2) enters into the cavity provided in the first frame body (1) from the opening direction of the first frame body (1), and the modular insertion core (2) is fixed in the first frame body (1) by means of a second frame body (3), wherein the second frame body (3) is detachably connected to the first frame body (1). Also provided are a connector, comprising the said fixing holder of the modular insertion core (2), and a mounting method for the connector. The fixing holder of the modular insertion core (2) can realize quick mounting of the modular insertion core (2), and the connector is reliable in connection and convenient to mount.
Patent EP-4110936-A1 (EP)
Inventor: FARMER SEAN
IPC: C12P7/64
Filed: 2021-02-04
Abstract: The subject invention provides materials and methods for producing, isolating, extracting and purifying single-molecule products. The subject invention provides materials and methods for extracting microbial metabolites at a high level of purity, for example, a purity of at least 80% by weight, and preferably at least 95% by weight or more. Specifically, the subject invention provides materials and methods for isolating or extracting biosurfactants and polyketides at a high level of purity. Preferably, the biosurfactant is a sophorolipid (SLP).
Patent EP-4118491-A1 (EP)
Inventor: ITO TAKUYA
IPC: G03G15/20
Filed: 2021-02-05
Abstract: An imaging system includes a housing that defines a housing space, a fuser disposed inside the housing space to fix a toner image onto a print medium, a collecting device including an ionizer and a particle filter, and a controller. The fuser is associated with operation history information. The ionizer of the collecting device includes a first electrode and a second electrode. The ionizer generates a discharge between the first electrode and the second electrode so as to charge floating particles that are discharged from the fuser. The particle filter of the collecting device collects the charged floating particles. The controller controls a current to flow between the first electrode and the second electrode due to the discharging, based on the operation history information of the fuser.
Patent EP-4204413-A1 (EP)
Title: Dihydroquinazolin-2-one derivatives as selective cytotoxic agents useful in the treatment of hiv
Inventor: CONVERSO ANTONELLA
IPC: C07D403/06
Filed: 2021-08-25
Abstract: The present disclosure is directed to tetrahydroquinazoline derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV naïve cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).
Patent EP-3998181-A1 (EP)
Title: Rotation lock device
Inventor: DOHI NAGAO
IPC: F16D125/28
Filed: 2021-03-17
Abstract: A structure of a rotation locking device that is easily configured and capable of keeping cost down is achieved.A rotation locking device 4 switches between a first mode where an engaging claw portion 14 engages with an engaging concave portion 9 by an output member 13 rotating an engaging member 8 due to an input member 12 being rotationally driven by an actuator 7, and rotation of a locking gear 5 supported by and fixed to an output shaft 3 of an automatic transmission 2 is restricted, and a second mode where engagement between the engaging claw portion 14 and the engaging concave portion 9 is released and rotation of the locking gear 5 is allowed.
Patent EP-4210621-A1 (EP)
Inventor: KNUDSEN CARSTEN
IPC: A61B42/50
Filed: 2021-09-07
Abstract: La présente invention concerne un gant et un appareil de distribution et d'enfilage de gant comprenant : un gant jetable comprenant une ouverture pour l'entrée de la main, ledit gant ayant un bord d'ouverture supérieur et un bord d'ouverture inférieur, dont l'un est pourvu d'un rabat qui peut être déchiré sans déstabiliser ni détruire le gant. Un premier et un second dispositif de saisie, ayant un bras apposé à une base comprenant un moyen de montage relié aux bras, ledit support comprenant le moyen de déplacement adapté de sorte qu'un ou les deux bras sont mobiles entre une première position dans laquelle les dispositifs de saisie sont placés à proximité, et une seconde position dans laquelle les dispositifs de saisie sont espacés l'un de l'autre, ledit appareil de distribution et d'enfilage de gant étant pourvu d'un support pour au moins un gant jetable. Un moyen de fixation est disposé sur lesdits dispositifs de saisie de sorte que lesdits dispositifs de saisie amènent l'ouverture pour l'entrée de la main à s'expanser, facilitant ainsi l'insertion d'une main dans ladite ouverture pour l'entrée de la main lorsque lesdits dispositifs de saisie sont déplacés depuis leur première vers leur seconde position. Le second dispositif de saisie est placé sur le support de sorte que le second dispositif de saisie retient le rabat fixé au bord d'ouverture inférieur du gant de sorte que le rabat est déchiré du gant le long du bord d'ouverture inférieur lorsqu'une main insérée dans le gant est déplacée loin du support, et le premier dispositif de saisie comprend un moyen qui supporte le bord d'ouverture supérieur d'une manière telle qu'il libère le gant lorsqu'une main insérée dans le gant est déplacée loin du support.
Patent EP-4214077-A1 (EP)
Inventor: MAMMERI AMRID
IPC: B60K11/02
Filed: 2021-09-08
Abstract: The present invention relates to a set of cooling modules (22, 22', 22'') for the front face of an electric or hybrid motor vehicle (10), said set of cooling modules (22, 22', 22'') comprising at least two cooling modules (22, 22', 22'') each one comprising - a heat exchanger (28, 28', 28'') intended to be connected to a cooling circuit, and - a turbomachine (30, 30', 30''), said cooling modules (22, 22', 22'') being juxtaposed in such a way as to have distinct air flows (F) passing through them.
Patent EP-4192337-A1 (EP)
Title: Tumor ablation planning using interstitial optical mapping
Inventor: KOENIG MATTHEW W
IPC: A61B5/00
Filed: 2021-08-02
Abstract: Devices, systems, and methods to generate a plan for an interstitial laser ablation procedure are disclosed. The systems may be configured as an interstitial optical mapping system including a catheter, an emitter optical fiber, an imaging optical fiber, a light source, and a processing unit. The emitter optical fiber and the imaging optical fiber are used to interstitially image a fluorescent dye associated with a tumor, including the tumor margin, at discrete imaging positions along a length of the catheter. The processor calculates a location of the fluorescent dye at each discrete position and creates an optical map representing the tumor. The optical map is used to generate an interstitial laser ablation plan that includes laser fiber pull-back positions.
Patent EP-4113370-A1 (EP)
Title: Method and device for updating object recognition model
Inventor: YUE JUN
IPC: G06K9/00
Filed: 2021-03-22
Abstract: This application provides a method and apparatus for updating an object recognition model in the field of artificial intelligence. In the technical solution provided in this application, a target image and first voice information of a user are obtained. The first voice information indicates a first category of a target object in the target image. A feature library of a first object recognition model is updated based on the target image and the first voice information. The updated first object recognition model includes a feature of the target object and a first label indicating the first category, and the feature of the target object corresponds to the first label. A recognition rate of an object recognition model can be improved more easily according to the technical solution provided in this application.
Patent EP-4126481-A1 (EP)
Inventor: HAHN ADAM J
IPC: B26B21/40
Filed: 2021-03-23
Abstract: A trimmer razor includes a handle, a head operatively connected to the handle, the head including a base member defining a cam track, a seat extending from the base member, and a cover connected to the seat; and an extension arrangement connecting the cover to the handle so that upon rotation of the handle, the cover is movable between an open position in which the cover is spaced from the seat and a closed position in which the cover is clamped to the seat, wherein the extension arrangement includes a rod connected to the cover and a cam pin extending from the rod, and wherein the cam pin is configured to follow the cam track so that when the cover moves from the closed position to the open position, the cover rotates relative to the seat.
Patent EP-4210569-A1 (EP)
Title: Quantitative imaging of the heart muscle
Inventor: PUENTMANN VALENTINA
IPC: A61B5/055
Filed: 2021-09-14
Abstract: The present invention provides a method for non-invasive quantitative imaging of a heart, the method comprising: obtaining an initial T1 map and a T2 map of the heart, and correcting the initial T1 map using the T2 map in order to obtain a corrected T1 map, wherein the correcting the initial T1 map comprises subtracting from a value in the initial T1 map a weighted value of the T2 map and adding a constant. The present invention also provides further methods and devices for non-invasive quantitative imaging of the heart.
Patent EP-4130625-A1 (EP)
Title: Storage box and refrigerator having the same
Inventor: MA MINGMING
IPC: F25D25/00
Filed: 2021-01-05
Abstract: The present application discloses a storage box, comprising an enclosure, a storage box body, a pivot shaft connected to the enclosure and the storage box body, an elastic element disposed between the pivot shaft and the enclosure, and a locking device, wherein the elastic element always provides a driving force driving the storage box body to turn outwards the enclosure about the pivot shaft; the locking device comprises a locking portion disposed on the enclosure, and a fitting portion which is disposed on the storage box body and push-fitted with the locking portion. The storage box body can automatically turn without a handle being disposed, thereby expanding the space for storing items.
Patent EP-4225104-A1 (EP)
Title: Device for fastening a front panel to a side frame of a drawer
Inventor: LÖH ANDREAS
IPC: A47B88/956
Filed: 2021-10-05
Abstract: The invention relates to a device (6) for fastening a front panel (2) to a side frame (3) of a drawer (1), the device comprising a support (8), which can be fixed to a front panel (2), and an adapter (10, 11), which can be fixed to a side frame (3) and on which the support (8) is adjustably held, wherein the support (8) can be inserted by means of a retaining projection (20) into a receptacle (14) in the adapter (10, 11) and can be fixed by a catch element (30), wherein the catch element (30, 30') is in the form of a flexible spring that latches by means of one limb (31) over a protrusion (21) on the retaining projection (20). As a result, the front panel (2) can be effectively mounted on the side frame (3) using simple means.
Patent EP-4214209-A1 (EP)
Title: Indole derivatives as ras inhibitors in the treatment of cancer
Inventor: AAY NAING
IPC: C07D471/22
Filed: 2021-09-15
Abstract: The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
Patent EP-4196932-A1 (EP)
Inventor: JOHNSON MICHAEL CHARLES
IPC: G06Q10/08
Filed: 2021-09-07
Abstract: A method for executing orders assigned to a plurality of robots operating in a warehouse, including receiving an order with a plurality of items, each item associated with an item location. The method includes defining a plurality of regions and identifying the regions which include at least one item location associated with the order received by the robot. The method also includes determining, from the regions identified, which regions which include at least one operator and assessing criteria relating to a current location of the robot and to the item locations associated with the regions having at least one operator. The method further includes selecting an item location to which the robot is to navigate from a current location based on an assessment of criteria relating to the current location of the robot and to the item locations associated with the regions in which are located at least one operator.
Patent EP-4145701-A1 (EP)
Inventor: PARK NAM SHIN
IPC: H03H3/007
Filed: 2021-04-28
Abstract: The present invention relates to a filter and a method of manufacturing the same, the filter including an RF connector configured to have a predetermined electrical signal line, a filter body having at least one impedance matching space in which the RF connector is installed, a relevant PCB on which one end of the RF connector is fixedly mounted, the relevant PCB coupled to be in close contact with one side surface of the filter body, and an annular gasket interposed between one side surface of the filter body and the relevant PCB to block a signal leak, in which a concave-convex portion is processed on a surface of one side surface of the filter body to which the annular gasket is attached to increase an attachment area, thereby providing an advantage of improving a bonding force of an attachment portion to which the gasket is attached.
Patent EP-4237263-A1 (EP)
Inventor: SCHEEPERS PETER
IPC: B60C25/05
Filed: 2021-10-26
Abstract: Dismounting machine for dismounting a tyre from a rim, comprising a supporting base frame that is provided with: - a vertical carrying body for a rim, wherein said carrying body is connected to the base frame, is rotatable by a motor relative to the base frame about a rotation axis that extends in a vertical direction, and is provided with fastening means for fastening a rim in a fixed position on an upper side of the carrying body, so that a principal axis of the rim thus fixed extends in a direction that coincides with the central rotation axis of the carrying body, so that rotation of the carrying body leads to rotation of the fixed rim about the principal axis, - a vertical column connected rigidly to the base frame, which is located at a distance from the carrying body, said column being provided with a guide arm and an auxiliary arm, which extend from the column in the direction of the carrying body, and which, movable independently of one another, are connected to the column, so that the guide arm and the auxiliary arm can be placed independently of one another in a working position as separate tools for dismounting a tyre from a rim fixed on the carrying body.