Patent SG-11201407819U-A (SG)
Title: Improved methods of cell culture for adoptive cell therapy
Inventor: WILSON JOHN R
IPC: A61K35/51
Filed: 2013-06-11
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 December 2013 (19.12.2013) WIPOIPCT (10) International Publication Number WO 2013/188427 A1 (51) International Patent Classification: C12N 5/0783 (2010.01) A61K35/12 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/045209 11 June 2013 (11.06.2013) English English (30) Priority Data: 13/493,768 11 June 2012 (11.06.2012) (71) Applicant: WILSON WOLF MANUFACTURING CORPORATION [US/US]; 33 5th Avenue NW, Suite 700, New Brighton, MN 55112 (US). (72) Inventor: WILSON, John, R.; 173 Windsor Lane, New Brighton, MN 55112 (US). (74) Agents: DICKSON, Thomas, G. et al.; Patterson Thuente Pedersen, P.A., 4800 IDS Center, 80 South Eighth Street, Minneapolis, MN 55402-2100 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Ug (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (54) Title: IMPROVED METHODS OF CELL CULTURE FOR ADOPTIVE CELL THERAPY l> CJ •t 00 00 i-H en i-H o CJ O £ Fig. 14 A= CONVENTIONAL METHOD • = NOVEL METHOD (57) Abstract: Production and use of novel therapeutic cells, called T-Vehicles, in the allogeneic Adoptive Cell Therapy setting al­ lows a wide range of therapeutic benefits to accrue with minimal or no risk of GVHD. T-Vehicles are created from donor cells that T are altered to contain therapeutic attributes that do not include their native antigen receptors and can deliver therapeutic benefits ir­ relevant of their native antigen specificity. T-Vehicles can possess highly restricted native antigen specificity that renders them un - able recognize antigens present to on normal cells and incapable of initiating GVHD, making them ideal transport vehicles to deliver various therapeutic attributes in vivo. In essence, production and use of T-Vehicles is a paradigm shift that opens the door to thera­ peutic application of cells T in ways not previously contemplated, independent of whether or not there is an HLA match between the donor and the recipient.