baber/WOPTO huggingface dataset:
Patent ES-2924933-T3 (ES)
Title: Derivados de piridina y usos terapéuticos de los mismos como inhibidores de TRPC6
Inventor: BOUYSSOU THIERRY
IPC: C07D498/08
Filed: 2018-10-25
Granted: 2022-10-11
Abstract: La invención se refiere a nuevos compuestos que tienen actividad inhibidora de TRPC6 y sus sales farmacéuticamente aceptables. La invención también se refiere a composiciones farmacéuticas que comprenden estos compuestos, usando estos compuestos en el tratamiento de varias enfermedades y trastornos, procesos para preparar estos compuestos e intermedios útiles en estos procesos.   (Traducción automática con Google Translate, sin valor legal)
Patent ES-2953753-T3 (ES)
Title: Dispositivo de taponado a rosca destinado a permanecer fijado a un recipiente después de la apertura del recipiente
Inventor: MÉLAN-MOUTET MATHIAS
IPC: B65D55/16
Filed: 2020-11-27
Granted: 2023-11-15
Abstract: - Dispositivo taponador de rosca destinado a permanecer unido a un recipiente después de abrir el mismo. - El dispositivo comprende una pared cilíndrica (10) que tiene un tramo (6) que comprende un extremo cerrado (8) por un fondo (5) y un tramo (7) que comprende un extremo abierto (9), estando conectado el tramo (6) a la sección (7) por una unión circunferencial (15) que comprende una conexión no fracturable (16) y una conexión fracturable (17), comprendiendo además la sección (7) una conexión fracturable (19) que se extiende paralela a la unión circunferencial (15) y que tiene una parte (20) de forma redondeada, siendo la conexión fracturable (17) y la conexión fracturable (19) susceptibles de fracturarse durante un primer desenroscado del tramo (6). La fractura de las conexiones fracturables permite crear dos brazos que retienen el tramo (6) al contenedor.  (Traducción automática con Google Translate, sin valor legal)
Patent ES-2954407-T3 (ES)
Title: Procedimiento para soldar al menos un manguito de soldadura a una pieza de conexión
Inventor: SCHARKOWSKI OLIVER
IPC: B23K20/10
Filed: 2020-01-21
Granted: 2023-11-22
Abstract: La invención se refiere a un método para soldar al menos un manguito de soldadura a una pieza de conexión eléctrica. La invención también se refiere a un sistema que comprende un manguito de soldadura y una pieza de conexión eléctrica, así como a un dispositivo de soldadura por ultrasonidos que comprende una herramienta de soldadura por ultrasonidos, en particular con un sonotrodo.  (Traducción automática con Google Translate, sin valor legal)
Patent ES-2949213-T3 (ES)
Title: Acristalamiento con transpondedor de RFID
Inventor: DRÖGE ALICIA
IPC: E06B3/263
Filed: 2020-07-01
Granted: 2023-09-26
Abstract: La invención se refiere a un acristalamiento (2), en particular acristalamiento de fachada, ventana, puerta o separador de ambientes interior, que comprende: - un marco (3) que consta de un primer elemento de marco metálico (3.1), un segundo elemento de marco metálico (3.2) y un tercer elemento de marco polimérico (3.3) de conexión que rodea los elementos de marco (3.1, 3.2) al menos en algunas secciones y preferentemente en su totalidad, y - un acristalamiento dispuesto en el marco (3), en el que - al menos un RFID un transpondedor (9) está dispuesto en una de las caras interiores del marco (3), - un elemento de acoplamiento (10) en forma de tira está acoplado electromagnéticamente al transpondedor RFID (9), y - el elemento de acoplamiento (10) está acoplado a uno de los elementos de marco metálico (3.1, 3.2) en al menos una zona de acoplamiento (15) y está acoplado preferentemente galvánica o capacitivamente con cada uno de los elementos de marco metálico (3.1, 3.2) en dos zonas de acoplamiento (15, 15').  (Traducción automática con Google Translate, sin valor legal)
Patent ES-2940582-T3 (ES)
Title: Una lámpara de filamento LED
Inventor: WOUTERS VINCENT
IPC: F21K9/238
Filed: 2020-09-02
Granted: 2023-05-09
Abstract: La invención proporciona una lámpara de filamento LED (10) que comprende: una envoltura (11) que encierra una cámara (13) sellada con un vástago (12), en el que el vástago se extiende dentro de dicha cámara; una estructura de filamento LED (14) con al menos dos segmentos controlables individualmente (141-145); un controlador (15) configurado para recibir una señal de control y controlar cada uno de los al menos dos segmentos controlables individualmente en función de dicha señal de control, donde la estructura de filamento LED (14) y el controlador (15) están dispuestos dentro de la cámara (13) ; un circuito controlador (16) dispuesto fuera de la cámara, donde el circuito controlador comprende dos líneas eléctricas (161, 162) que se extienden a través del vástago (12) o la envoltura (11) para alimentar la estructura de filamento LED (14) y el controlador (15),  (Traducción automática con Google Translate, sin valor legal)
Patent ES-2037656-T3 (ES)
IPC: A61K31/35
Filed: 1986-11-14
Granted: 1993-07-01
Abstract: This invention relates to forskolin derivatives, their physiologically acceptable salts, and a process for producing these com<sub>D</sub>ounds. The forskolin derivative is represented by the general formulawherein;I. when R' is hydrogen and R<sup>4</sup> is vinyl, ethyl, or cyclopropyl,(1) either of R<sup>2 </sup>and R<sup>3</sup> denotes a residue represented by the formulawherein each of R<sup>5</sup> and R<sup>6</sup> denotes hydrogen or lower alkyl or R<sup>6</sup> and R<sup>6</sup> combine with each other to form a lower alkylene chain which may or may not contain an oxygen or nitrogen atom and m is an integer of 1 to 5, and the other one of R<sup>2</sup> and R<sup>3</sup> denotes hydrogen or a residue represented by the formula CO(CH<sub>2</sub>)<sub>n</sub>X, X being hydrogen orwherein, each of R<sup>7</sup> and R<sup>8</sup> denotes hydrogen or lower alkyl or R<sup>7</sup> and R<sup>8</sup> combine with each other to form a lower alkylene chain which may or may not contain an oxygen or nitrogen atom, and n being an integer of 1 to 5, or(2) R<sup>2</sup> denotes hydrogen or -COCH<sub>2</sub>CH<sub>2</sub>CO<sub>2</sub>H and R<sup>3</sup> denotes hydrogen, -COCH<sub>3</sub>, -COCH<sub>2</sub>CH<sub>2</sub>CH<sub>2</sub>CO<sub>2</sub>H, or -COCH(OH)CH<sub>2</sub>OH with the proviso that R<sup>3</sup> is one of the last two residues when R<sup>2</sup> is hydrogen, andII. when R' is a residue represented by a formula of CO(CH<sub>2</sub>)<sub>p</sub>CO<sub>2</sub>H andwherein, each of R<sup>9</sup> and R<sup>10</sup> denotes hydrogen or lower alkyl, p is an integer of 0 to 5, and q is an integer of 1 to 5,R<sup>2</sup> denotes hydrogen, R<sup>3</sup> denotes acetyl, and R<sup>4</sup> denotes vinyl.
Patent ES-2038641-T3 (ES)
Title: Amidas del acido salicilico, procedimiento para su obtencion y su empleo.
IPC: A61P31/04
Filed: 1987-09-24
Granted: 1993-08-01
Abstract: LA INVENCION SE REFIERE A AMIDAS DEL ACIDO N-OCTIL-SALICILICO Y N-DECIL-SALICILICO, UN PROCEDIMIENTO PARA LA PREPARACION DE LOS COMPUESTOS CITADOS A PARTIR DE SALICILATO DE METILO Y UNA AMINA PRIMARIA ASI COMO LA APLICACION DE LAS AMIDAS EN COMPOSICIONES CON ACTIVIDAD ANTIMICROBIANA.
Patent ES-2028047-T3 (ES)
Title: Un procedimiento para producir articulos termoconformados.
IPC: B29C48/18
Filed: 1987-04-16
Granted: 1992-07-01
Abstract: UN PROCESO PARA PRODUCIR ARTICULOS TERMOFORMADOS CONSISTENTE EN (1+XN-X) CAPAS LAMINADAS COMPRENDIENDO LOS SUCESIVOS PASOS DE: A) PREPARAR UN POLIMERO TERMOPLASTICO LAMINADO POR EXTRUSION, DONDE CADA LAMINADO COMPRENDE N CAPAS DONDE N VALE 3,5 O 7 , ESTANDO LAS CAPAS SIMETRICAMENTE DISPUESTAS ALREDEDOR DE UNA CAPA CENTRAL; B) PRODUCIR ALOJAMIENTOS DE DICHOS LAMINADOS; C) APILAR X ALOJAMIENTOS JUNTOS DONDE N VALE 2,3 O 4; D) ADHERIR LOS ALOJAMIENTOS DE CADA PILA ENTRE SI; Y E) TERMOFORMAR CADA PILA PARA OBTENER UN ARTICULO DE FABRICACION.
Patent ES-2031511-T3 (ES)
IPC: C07F15/00
Filed: 1987-08-14
Granted: 1992-12-16
Abstract: Derivatives of platinum group metals, particularly platinum itself, wherein the metal is linked to one or more pharmaceutically acceptable steroid, fatty acid or other lipophilic residues aiding transport of the metal across cell membranes in the body, particularly fatty acid amine or fatty acid amide groups RCH2NH- or <CHEM> where R is a hydrocarbon group, suitably of 10 to 30 carbon atoms. The derivatives are useful in the treatment of cancer.
Patent ES-2058160-T3 (ES)
Inventor: KOSLOWSKI GUNTER
IPC: E01B25/24
Filed: 1988-03-18
Granted: 1994-11-01
Abstract: The present invention refers to a device for the centering of a movable rail section relative to a stationary rail section of an overhead trolley conveyor, notably a lifting station of a trolley conveyor. There is at least one centering body attached to the stationary or to the movable rail section. The centering body has a recess. At the movable rail section and at the stationary rail section, respectively, a centering piece is provided which can be moved into the recess. The centering piece can be rotated within the recess about an axis which extends in the direction of the rail so that it comes into engagement with at least one of the walls of the recess.
Patent ES-2039013-T3 (ES)
Title: Tapas de envases que tienen una resistencia aumentada.
IPC: B65D/
Filed: 1988-07-19
Granted: 1993-08-16
Abstract: SE PRESENTA UN CERRAMIENTO DE METAL PARA UN ENVASE QUE INCLUYE UN PANEL CENTRAL, UN ANILLO DEL PANEL CENTRAL CON UNA SUPERFICIE CURVA CONVEXA Y UNA PATA INTERIOR. EL CERRAMIENTO DE METAL ESTA PROVISTO CON UNA BANDA FORMADA MEDIANTE ACUÑAMIENTO PARA INCREMENTAR LA PRESION DEL PLIEGUE. LA BANDA ESTA DEFINIDA COMO UNO DE LOS CAMPOS DE TERSION INTERSECTANTES. EL ACUÑAMIENTO CONSIGUE UNA LONGITUD CURVILINEA TOTAL NO ACUÑADA QUE INCLUYE UNA PARTE DEL ANILLO DEL PANEL CENTRAL Y QUE OPCIONALMENTE INCLUYE UNA PARTE DEL PANEL CENTRAL Y / O UNA PARTE DE LA PATA INTERIOR. EN UNA DE SUS FORMAS, EL ACUÑAMIENTO PRODUCE DOS SUPERFICIES ACUÑADAS FRUSTOCONICAS. EN OTRA FORMA EL ACUÑAMIENO PRODUCE UNA SUPERFICIE ACUÑADA CURVILINEAL CON UN RESIDUO DE CUÑA GENERALMENTE CONSTANTE.
Patent ES-2028996-T3 (ES)
IPC: G01P5/10
Filed: 1988-09-14
Granted: 1992-07-16
Abstract: Direction-sensitive flow-rate indicator for gaseous or liquid media. It comprises a semi-conductor substrate on which for each dimensional direction at least one thermocouple is arranged, in which the connecting-leads of the ends of each thermocouple extend in the direction-of-flow component of the medium and are, at least about, perpendicular to each other. It also comprises a heating-element for generating a flow-rate dependent temperature-difference in the flowing medium in the longitudinal direction of the said thermocouples, which results in a flow-rate dependent thermo-voltage between the ends of the thermocouples.
Patent ES-2029517-T3 (ES)
IPC: A61M1/00
Filed: 1988-02-12
Granted: 1992-08-16
Abstract: A thoracic drainage unit has a liquid seal chamber (16) above the collection container(14). The seal chamber(16) has an overflow outlet tube(72) and an inlet tube (92) spaced from the inner wall of the seal chamber(16). Baffle walls(96,98) define an enclosed space through which the inlet tube (92) may be observed for bubbling and tidalling. Further baffle walls (84,86,88,90) separate foam from the liquid around the overflow tube(72).
Patent ES-2034361-T3 (ES)
IPC: B05C17/00
Filed: 1988-04-26
Granted: 1993-04-01
Abstract: A cartridge assembly for dispensing flowable masses includes axially extending containers each holding a separate flowable mass and a discharge member for dispensing the flowable masses from the containers. The discharge member and the containers are separate parts assembled into a unit. During storage and transport, the containers are closed and the discharge member is mounted on one end of the containers. When the cartridge assembly is to be used, the unit is inserted into a dispensing device. The discharge member and the containers are displaced relative to one another so that the discharge member moves against one end of the containers for forming openings. The other ends of the containers contain pistons which are pressed by the dispensing device toward the openings in the other ends of the containers forcing the flowable masses into the discharge member from which they are dispensed.
Patent ES-2056964-T3 (ES)
Inventor: BEHLING DIETER DR
IPC: C07C7/144
Filed: 1989-01-25
Granted: 1994-10-16
Abstract: A process is proposed, in which the air/permanent gas mixture (crude medium) is passed to a first gas separation membrane and is separated into a gas stream enriched in (permeate) organic compounds and a gas stream depleted of (retentate) organic compounds, in which the organic compounds are recovered from the enriched gas stream passed over a recovery apparatus. In the process the pressure of the primary air/permanent gas mixture is increased prior to entry into the first gas separation membrane and the pressure of the enriched gas stream is reduced after exit from the first gas separation membrane and the depleted gas stream leaving the gas separation membrane is released into the surroundings, a gas stream leaving the recovery apparatus being returned to the air/permanent gas mixture, after the pressure of this has been increased.
Patent ES-2046414-T3 (ES)
IPC: B23F21/02
Filed: 1989-09-05
Granted: 1994-02-01
Abstract: The invention relates to a grinding tool for producing external profiles, with a basic body (5) of steel, the circumferential surface (5b) of which is provided with a uniform coating (10) of superhard material which has been electrolytically applied to the basic body (5) with the use of a binding agent. The basic body (5) is designed as a disc with end faces (5a) running parallel to one another and at right angles to the rotational axis (6) and with a circumferential surface (5b) which in its entirety depicts the surface of a complete turn of a spiral. The complete cross-section of the profile (8) to be ground out of the respective workpiece is obtained in a radial section (I). A profile from the two opposed halves (8a and 8b), facing one another at a distance apart, of the axially split profile (8) is obtained in the radial section (V) lying on the same diameter and offset by 180 DEG . The profile halves (8a, 8b), in each case following the path of the spiral in an ascending or descending manner, complement one another in the intermediate radial sections (II, III, IV or VI, VII, VIII). <IMAGE>
Patent ES-2034932-T3 (ES)
Title: Articulo perfilado en espuma sintetica y metodo para su fabricacion.
IPC: B68G7/052
Filed: 1989-08-04
Granted: 1993-08-01
Abstract: SE DESCRIBE UN METODOPARA REALIZAR COJINES DE ESPUMA CONTORNEADA EN EL QUE DOS PLANCHAS DE ESPUMA (12,16) SE UNEN ENTRE SI POR ADHESIVO. UN RECUBRIMIENTO (10) SE FIJA A LA CARA DE UNA DE LAS PLANCHAS DE ESPUMA (12). SE APLICA PRESION AL RECUBRIMIENTO (10) DE FORMA QUE LA PLANCHA DE ESPUMA (12) SE COMPRIMA Y SE PONGA EN CONTACTO CON EL ADHESIVO (14) ENTRE LAS PLANCHAS DE ESPUMA (12,16), FORMANDO ASI LA CURVATURA. LA PRESION SE MANTIENE HASTA QUE EL ADHESIVO SE ENDURECE LO SUFICIENTE PARA MANTENER AL RECUBRIMIENTO (10) FORMANDO LA CURVATURA.
Patent ES-2068250-T3 (ES)
Inventor: MASAKI KAZUMI
IPC: H05B39/04
Filed: 1989-09-06
Granted: 1995-04-16
Abstract: Disclosed is a novel lighting device comprising a power source capable of supplying to a krypton lamp a voltage exceeding its rating, and a krypton lamp connected with an output terminal of said power source. Krypton lamp emits a natural light when lighted by energizing a voltage exceeding the rating. Such a light has superior color rendering properties, as well as a color temperature of about 2,900K or higher which is very close to that of early morning sunlight. Thus, the lighting device is advantageously used in luminares in general.
Patent ES-2055126-T3 (ES)
Title: Dispositivo para el ensamblaje de las vidrieras laminadas.
Inventor: TRIFFAUX FRANCIS
IPC: B32B43/00
Filed: 1989-07-06
Granted: 1994-08-16
Abstract: EL INVENTO CONCIERNE UN DISPOSITIVO PARA EL ENSAMBLAJE DE LAS VIDRIERAS LAMINADAS POR PRENSADO. EL DISPOSITIVO SEGUN EL INVENTO COMPRENDE AL MENOS UN CONJUNTO (2,4) DE RODILLOS DE PRENSADO (3,5) DIVIDIDO EN AL MENOS DOS (9,10, 11) SUBCONJUNTOS DE RODILLOS DE PRENSADO (3,5), CADA SUBCONJUNTO ESTA MONTADO SOBRE UNA VIGA (13) CUYA POSICION PUEDE SER MODIFICADA Y REGULADA EN RELACION A LA POSICION DE LAS OTRAS VIGAS (12,14).
Patent ES-2034793-T3 (ES)
IPC: G01C21/28
Filed: 1990-04-10
Granted: 1993-04-01
Abstract: In a navigation system with a magnetic field sensor (2), installed in a vehicle, for determining direction and with additionally available location data, an angular installation error of the magnetic field sensor is determined in the following manner: the difference is formed from the measured actual value of the direction and the nominal value determined from known location data for the direction and is stored in accordance with the direction of the nominal value, in an associated sector memory, forming the mean value. If the mean values in all sector memories significantly correspond to one another, a total mean value is formed from the mean values and is used as the rotation error for correcting the direction measurement. <IMAGE>
Patent ES-2075122-T3 (ES)
Title: Pieza moldeada, especialmente leva de una aleacion sinterizada, fabricada por metalurgia de polvos y procedimiento para su fabricacion.
Inventor: LEITHNER KARL
IPC: B22F3/26
Filed: 1990-12-03
Granted: 1995-10-01
Abstract: LA INVENCION SE REFIERE A UNA LEVA QUE SE EMPLEA EN TRANSMISIONES DE MAQUINAS DE COMBUSTION INTERNA, SE FABRICA A PARTIR DE UNA ALEACION SINTERIZADA EN UN PROCESO DE PULVIMETALURGIA Y ES MUY RESISTENTE AL DESGASTE Y SE CARACTERIZA PORQUE; LA ALEACION PRESENTA UNA MATRIZ ENDURECIDA INCRUSTADA CON COBRE Y CONSISTE EN UN 0,5 A 16% EN PESO DE MOLIBDENO, UN 1 A 20% EN PESO DE COBRE, UN 0,1 A 1,5% EN PESO DE CARBONO, UNAS TRAZAS DE ELEMENTOS ELEGIDOS ENTRE MANGANESO, CROMO Y NIQUEL CUYO PORCENTAJE TOTAL ES UN 5% EN PESO Y EL RESTO HIERRO.
Patent ES-2071007-T3 (ES)
Title: Transmision mixta y su control de cambio de velocidades.
Inventor: STINE ALAN CHARLES
IPC: F16H63/30
Filed: 1990-02-09
Granted: 1995-06-16
Abstract: SE PROPORCIONA UNA TRANSMISION COMPUESTA (10) CONSISTENTE EN UNA SECCION PRINCIPAL DE TRANSMISION (12) CONECTADA EN SERIE CON UNA UNIDAD DE TREN DE TRANSMISION AUXILIAR DE MULTIPLES VELOCIDADES DE TIPO DE REGIMEN (14) CON AL MENOS DOS RAZONES DE TIPO DE REGIMEN SELECCIONABLES Y UNA UNIDAD DE CONTROL DE CAMBIO DE MARCHA COMBINADA (56) PARA LA MISMA.
Patent ES-2075144-T3 (ES)
Title: Cable de fibra optica.
Inventor: SMITH LAWRENCE IAN
IPC: G02B6/44
Filed: 1990-02-28
Granted: 1995-10-01
Abstract: UN CABLE DE FIBRA OPTICA QUE COMPRENDE UN ALMA CENTRAL 2L GENERALMENTE NO METALICA, ENCERRADA EN UN TUBO METALICO RIGIDO 22, POR LO MENOS UNA CAPA DE MIEMBROS DE REFUERZO LONGITUDINALES 6,11, LOS CUALES, O EL INTERNO DE LOS MISMOS, CUBRE Y ESTA EN CONTACTO CON EL TUBO METALICO RIGIDO. Y MEDIOS DE REVESTIMENTO L3 QUE CUBREN LA CAPA DE MIEMBRO DE REFUERZO, INCLUYENDO LA CAPA DEL MIEMBRO DE REFUERZO, EN UN HUECO O HUECOS RESPECTIVOS, POR LO MENOS UN TUBO METALICO SOLDADO LONGITUDINALMENTE 7, DENTRO DEL CUAL ESTA ENCERRADA POR LO MENOS UNA FIBRA OPTICA.
Patent ES-2070285-T3 (ES)
Inventor: BOQUILLON JEAN-PIERRE
IPC: B23K26/14
Filed: 1990-01-17
Granted: 1995-06-01
Abstract: Process and device for cleaning pollutants from a surface using a laser for applying laser pulses to the surface to be cleaned, in which the laser is pulsed in pulse durations not exceeding 30 nanoseconds, the area on the surface is contacted with the pulsating laser, the surface is cleaned in the absence of an observably thermal effect, and the laser is removed from the area on the surface after the area is cleaned, the laser beam is manipulated by means of a hand piece, and an optical system is provided to separate the laser beam into a plurality of individual laser beams with energies approximately equal to each other, and guided by an optical fiber assembly together with a recombining of the individual beams into a single laser beam, and the afocal optical assembly for adjusting the diameter of the recombined laser beams.
Patent ES-2039125-T3 (ES)
Title: Una unidad para accionar una transmision desembragable a cuatro ruedas motrices.
IPC: F16H59/02
Filed: 1990-12-04
Granted: 1993-08-16
Abstract: UNA UNIDAD FUNCIONAL PARA UNA TRANSMISION DE IMPULSION POR CUATRO RUEDAS DESEMBRAGABLE PARA VEHICULOS CONSTA DE UNA PALANCA DE ENGRANAJE (6) Y UNA PALANCA (7) QUE SE PUEDE DESLIZAR Y ROTAR PARA EMBRAGAR Y DESEMBRAGAR LA IMPULSION POR CUATRO RUEDAS Y UN ENGRANAJE DE REDUCCION RESPECTIVAMENTE. EN LA PALANCA HAY UNA VARILLA (50) DESLIZABLE QUE ABRE Y CIERRA EL DIFERENCIAL CUANDO LA IMPULSION POR CUATRO RUEDAS Y EL ENGRANAJE DE REDUCCION ESTAN EMBRAGADOS. LAS DOS PALANCAS (6, 50) SE APOYAN EN UN MISMO ALOJAMIENTO (5) QUE CONTIENE LOS MECANISMOS DE ACTUACION CINEMATICA CORRESPONDIENTES.
Patent ES-2049476-T3 (ES)
Inventor: GRIEBEL EDGAR
IPC: E06B9/06
Filed: 1990-05-04
Granted: 1994-04-16
Abstract: Proposed is a vertically opening sectional door whose segments (2) are connected to each other at their edges so that they can pivot, the segments (2) being folded on each other in alternating fashion in the peripheral region of the door (1) when the door is open.
Patent ES-2087161-T3 (ES)
Inventor: ROGERS WALTER JOHN JR
IPC: A61K49/00
Filed: 1990-07-19
Granted: 1996-07-16
Abstract: Accordingly, the present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The perfluoro-t-butyl (PFTB) moiety,   <IMAGE>   is an excellent reported group for fluorine-19 NMR/MRI. It is a source of nine magnetically equivalent fluorine nuclei which generate a single intense resonance for each detection in spectroscopy or imaging. This signal is a sharp singlet, not split by neighboring nuclei or spread over a wide frequency range and eliminates any change of ghost images which might arise from multiple resonances. These spectral properties ensure a maximum signal-to-noise ratio (S/N) for readily detecting this moiety. The foregoing allows either reduction in the concentration of the derivatized compound, ability to use MRI instruments with lower field strengths, a reduction in imaging times, or a combination of the foregoing as a result of this moiety producing a single, sharp, intense resonance. Additionally, the PFTB moiety-containing compounds may be utilized to determine oxygen concentration in aqueous solutions present in animate and inanimate objects.
Patent ES-2099714-T3 (ES)
Inventor: VAN DE VEN WILLEM JAN MARIE
IPC: A61K38/46
Filed: 1990-10-12
Granted: 1997-06-01
Abstract: The invention is based on the finding that furin belongs to a family of endoproteolytically active enzymes and relates to a process for the in vitro cleavage of a protein by treating the protein in the presence of Ca<2+> ions with furin or a furin-like enzyme, or an endoproteolytically active fragment, derivative or fusion protein of furin or furin-like enzyme. The invention can be used for the (micro)biological production of a protein by culturing genetically engineered cells expressing a pro-form of the protein as well as furin or a furin-like enzyme and isolating the protein formed.