Patent SG-11201810561Y-A (SG)
Title: Liquid neurotoxin formulation stabilized with tryptophan or tyrosine
Inventor: JARSTAD ANDERS
IPC: A61K31/506
Filed: 2017-05-26
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111111111 010111010 11111 0 01 010 11111 010 11111 1011110 111110 1111 0111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2017/203038 Al 30 November 2017 (30.11.2017) WIPO I PCT (51) International Patent Classification: MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, A61K 38/48 (2006.01) A61K 31/405 (2006.01) PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, A61K 47/02 (2006.01) A61K 31/506 (2006.01) SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, A61K 47/26 (2006.01) A61K 47/18 (2017.01) TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (21) International Application Number: (84) Designated States (unless otherwise indicated, for every PCT/EP2017/062785 kind of regional protection available): ARIPO (BW, GH, (22) International Filing Date: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 26 May 2017 (26.05.2017) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (25) Filing Language: English EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (26) Publication Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (30) Priority Data: KM, ML, MR, NE, SN, TD, TG). PCT/EP2016/062085 27 May 2016 (27.05.2016) EP Published: — with international search report (Art. 21(3)) (71) Applicant (for AL, AM, AT, AU, AZ BA, BE, BG, BR, BY, — with sequence listing part of description (Rule 5.2(a)) CA, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GE, GR, HR, HU, IE, IN, IS, IT, KG, KR, KZ, LT, LU, LV, MC, MD, ME, MK, MT, MX, NL, NO, NZ, PL, PT, RO, _ RS, RU, SE, SI, SK, SM, TJ, TM, TR, UA, US, UZ only): IPSEN BIOPHARM LIMITED [GB/GB]; Unit 9, Ash — = Road, Wrexham Industrial Estate, WREXHAM LL13 9UF (GB). = Applicant (for all designated States except AU, BA, BR, (71) — = _ CA, CN, GE, IN, KR, ME, MX, NZ, UA, US, UZ): NES- = TLE SKIN HEALTH SA [CH/CH]; Avenue Gratta-Paille 2, 1018 LAUSANNE (CH). Inventors: JARSTAD, Anders; Bernadottevagen 1 L, 756 (72) 48 UPPSALA (SE). FRIIS, Anna; Danmarks-Berga 57, 755 98 UPPSALA (SE). STAHL, Ulf; Solrosgatan 9, 75324 = = UPPSALA (SE). GURELL, Ann; Karlbergsvagen 71 B, Igh 1201, 113 35 STOCKHOLM (SE). AGREN, Barbro; = = Ytterocke 212, 830 02 MATTMAR (SE). EDSTROM, Emilia; Oslogatan 61, 75264 UPPSALA (SE). PICKETT, Andrew; Halsomsvagen 35, 757 57 UPPSALA (SE). = = = Agent: MENA, Sandra et al.; Cabinet BEAU DE (74) = LOMENIE, 158 me de l'Universite, 75340 PARIS (FR). = = Designated States (unless otherwise indicated, for every (81) = kind of national protection available): AE, AG, AL, AM, — AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, — 1-1 KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, cc M (54) Title: LIQUID NEUROTOXIN FORMULATION STABILIZED WITH TRYPTOPHAN OR TYROSINE 0 M (57) : The invention relates to stable liquid neurotoxin formulations which are free of animal proteins, comprising a surfactant, an amino acid selected from tryptophan and tyrosine, a buffer comprising sodium, chloride and phosphate ions, which have a pH between el ---- 5.5 and 8, and which are stable for 2 months. These compositions are suitable for use in therapy and in particular for administration to a IN patient to achieve a desired therapeutic or aesthetic effect. The invention also relates to the use of an amino acid selected from tryptophan © and tyrosine to protect a proteinaceous neurotoxin from degradation in a liquid composition which is free of animal derived proteins. N C