Patent SG-11201908571U-A (SG)
Title: Leveraging sequence-based fecal microbial community survey data to identify a composite biomarker for colorectal cancer
Inventor: DESANTIS TODD ZACHARY
IPC: C12Q1/689
Filed: 2018-03-16
Abstract: Analysisflow: W O 18/ 17 0396 Al Advanm Search • r , ons) oriklge of ...aioaaal pre-oxieting studio (n.2) Rao sequence da/o evailabledared n.13 Saain Select - UPPRSE (SS4.1P) Saroples<100 isadi pa stook =mg axe n< learrOes Paftano rkomeeled to metre chemotherapy or Whammy IndiAchal OTIJ WoMP*. ly • :SUP as d CRA Pa DESeq2 - 7 OKI/motel. CRA Vs ill.dy*Olsoese_sitte control FIG. 1 Per ftry0ESeq2 7 ONet.thre nen mo DESeq2 result brat lest508.5er6orier ei CRC Miele ari or \ 4 Ckle: Rondo Ifieds model tuba duly as a Wan fled FOI ....iambs] pen coat V. ailiassery(Cia aCerhol,CKVsGRN k URN aholl (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIP0 I PCT omit VIII °nolo olomonoolioiliflo oimIE (10) International Publication Number WO 2018/170396 Al (51) International Patent Classification: C12Q 1/689 (2018.01) C12Q 1/04 (2006.01) C12Q 1/6888 (2018.01) (21) International Application Number: PCT/US2018/022862 (22) International Filing Date: 16 March 2018 (16.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/472,863 17 March 2017 (17.03.2017) US (71) Applicants: SECOND GENOME, INC. [US/US]; 341 Allerton Avenue, South San Francisco, California 94080 (US). BAYLOR COLLEGE OF MEDICINE [US/US]; One Baylor Plaza, Houston, Texas 77030 (US). (72) Inventors: DESANTIS, Todd Zachary; 626 Salem Court, Livermore, California 94551 (US). WEINMAIER, Thomas; 728 Jamestown Avenue, San Francisco, Califor- nia 94124 (US). SHAH, Manasi Sanjay; 50 Washington St, Apt. 12, Santa Clara, California 95050 (US). HOL- LISTER-BRANTON, Emily Brooke; 5514 Willowbend Blvd., Houston, Texas 77096 (US). (74) Agent: HOLLY, David Christopher et al.; Cooley LLP, 1299 Pennsylvania Avenue, N.W., Suite 700, Washington, District of Columbia 20004 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: LEVERAGING SEQUENCE-BASED FECAL MICROBIAL COMMUNITY SURVEY DATA TO IDENTIFY A COM- POSITE BIOMARKER FOR COLORECTAL CANCER (57) : The present disclosure provides fecal microbial markers for di- agnosing colorectal cancer and colorectal adenoma. The present disclosure al- so provides methods for diagnosing colorectal cancer and colorectal adenoma using these intestinal microbial markers. [Continued on next page] WO 2018/170396 Al MIDEDIMOMOIDEIREEMOMMEHMOHOROMEMOIS TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))