Patent SG-11201903871T-A (SG)
Title: Substituted bicycle heterocyclic derivatives useful as romk channel inhibitors
Inventor: GUNAGA PRASHANTHA
IPC: A61K31/4439
Filed: 2017-11-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/093569 Al 24 May 2018 (24.05.2018) W I PO I PCT (51) International Patent Classification: Company, Route 206 and Province Line Road, Princeton, CO7D 405/14 (2006.01) A61P 9/00 (2006.01) New Jersey 08543 (US). RICHTER, Jeremy; c/o Bris- CO7D 413/14 (2006.01) A61K 31/444 (2006.01) tol-Myers Squibb Company, Route 206 and Province Line C07D 417/14 (2006.01) A61K 31/4439 (2006.01) Road, Princeton, New Jersey 08543 (US). A61P 13/02 (2006.01) (74) Agent: VANATTEN, Mary K. et al.; Bristol-Myers (21) International Application Number: Squibb Company, Route 206 and Province Line Road, PCT/US2017/059642 Princeton, New Jersey 08543 (US). (22) International Filing Date: (81) Designated States (unless otherwise indicated, for every 02 November 2017 (02.11.2017) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (25) Filing Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (26) Publication Language: English DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (30) Priority Data: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 201611037609 03 November 2016 (03.11.2016) IN MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, [US/US]; Route 206 and Province Line Road, Princeton, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, New Jersey 08543 (US). TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventors: GUNAGA, Prashantha; c/o Syngene Inter- (84) Designated States (unless otherwise indicated, for every national Limited, Biocon Special Economic Zone, Bio- kind of regional protection available): ARIPO (BW, GH, con Park, Plot No. 2&3, Bommasandra Industrial Area IV GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, Phase, Jigani Link Road, Bommasandra, Karnataka Ban- UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, galore 560 099 (IN). BHIDE, Rajeev S.; 22 Hawthorne TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Drive, Princeton Junction, New Jersey 08550 (US). BO- EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, RA, Rajesh Onkardas; c/o Syngene International Limit- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, ed, Biocon Special Economic Zone, Biocon Park, Plot No. TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, 2&3, Bommasandra Industrial Area IV Phase, Jigani Link KM, ML, MR, NE, SN, TD, TG). = Road, Bommasandra, Karnataka Bangalore 560 099 (IN). PANDA, Manoranjan; c/o Syngene International Limit- Declarations under Rule 4.17: ed, Biocon Special Economic Zone, Biocon Park, Plot No. — as to applicant's entitlement to apply for and be granted a 2&3, Bommasandra Industrial Area IV Phase, Jigani Link patent (Rule 4.17(ii)) Road, Bommasandra, Karnataka Bangalore 560 099 (IN). — as to the applicant's entitlement to claim the priority of the YADAV, Navnath Dnyanoba; c/o Syngene International earlier application (Rule 4.17(iii)) Limited, Biocon Special Economic Zone, Biocon Park, Plot — of inventorship (Rule 4.17(iv)) No. 2&3, Bommasandra Industrial Area IV Phase, Jigani Link Road, Bommasandra, Karnataka Bangalore 560 099 (IN). PRIESTLEY, Eldon Scott; c/o Bristol-Myers Squibb (54) Title: SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS (57) : Disclosed are compounds of Formula (I) or a salt there- L 1 L2 of, wherein R i is (II) or (III); each W is independently NRit, or 0; Z R1' , N R2 is a bond or CHR ld ; and R 1 , R 2 , R d , R 3 , L i , L 2 , R la , R ib , R ic , and n 1-1 .4 R R I 3 are define herein. Also disclosed are methods of using such compounds 0 (Rd (I) ), as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascu- 0 (Ria)n lar diseases. 1 1 in Cr) (R 1a ) n /, W----/z. 0).1''''''' I I C7\ © ---.... C3' Z I W\"'-/ y------„„.. (II) Ric (III) 00 11 © ei C [Continued on next page] WO 2018/093569 Al MIDEDIMOMMIDIREIERINOMEHHOMEHOM Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of