Patent SG-11201405137Q-A (SG)
Title: ANTIGEN-BINDING MOLECULE FOR PROMOTING DISAPPEARANCE OF ANTIGEN VIA FcγRIIB
Inventor: IGAWA TOMOYUKI
IPC: C12P21/02
Filed: 2013-02-22
Abstract: (i2) mwu ft iz s-5 iv x m £ titz s issaj n d9) mm IHMMi (43) m&'&m a 2013 ^ 8 R 29 0(29.08.2013) WIPOIPCT (10) WO 2013/125667 A1 (51) A61K39/395 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) (21) (22) (25) (26) s In: C12P 21/02 ( 2006.01) C07K16/18 (2006.01) PCT/JP2013/054461 2013 2 M 22 0(22.02.2013) (30) fiBfefix — PCT/JP2012/054624 2012 ^ 2 M 24 0 (24.02.2012) JP 2012-185866 2012 ^8^ 24 0(24.08.2012) JP PCT/JP2012/075092 2012 ^ 9 ^ 28 0(28.09.2012) JP (71) ttiH A: ^ ^ it £ tt (CHUGAI SELYAKU KABUSHIKI KAISHA) [JP/JP]; T 1158543 KifvtMt 5TI 5§1 ^ Tokyo (JP). (72) H?£.(IGAWA, Tomoyuki); T4128513 1TI1 3 5#±fe Shizuoka (JP). HU H §tjt(MAEDA, Atsuhiko); T 4128513 IIKI rfT,|6]P^ 1 T@ 1 3 5fffi Shizuoka (JP). SWP %j£B(IWAYANAGI, Yuki); T4128513 lllllft ITII 3 5#±fe + msmtta # # l*l Shizuoka (JP). J! ^ ® X (HARAYA, Kenta); T4128513 ilUftftPlxilrfiifilP ! 6 1TI 1 3 5fift Shizuoka (JP). g H C(KA I AI)A, Hitoshi); T 4128513 It H !ft $P !x JSrtri&pi ITII 3 5#±fe l*l Shizuoka (JP). IE<K6[5(KAI)0\0, Shojiro); T2478530 ft £ J11 !ft ft ft Tfi £ JI 2 0 0#±fc tp Kanagawa (JP). P* 7L (MIMOTO, Futa); T4128513 IIH R$P!x±STfTJ|6] P] 6 1TI1 35|tfe + Shizuoka (JP). (74) ftlA: )t 7K ft] Ju. , $1- (SHIMIZU, Hatsushi et al.); T 3000847 1-1-1 gift O < IS \f)l 6 p-e Ibaraki (JP). (8i) IS ft nJ f b): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) *!£H (asrofci^isy > ±T(Dmm(Dfcm% 11^ nlfb): ARIPO (BW, GM, KE, GH, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), 3. — =j V 7 (AM, AZ, BY, KG, KZ, RU, TJ, TM), 3 — • V / ^ (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). ^I\"j4.17lC^f •f&EfJST (£MIJJ 4.17(ii)) - (&&£ 21 &(3» - wffiWamma&fttLxmLtzWim'jxb (StfJJ 5.2(a)) l> CJ i-H cn i-H o CJ o & (54) Title: ANTIGEN-BINDING MOLECULE FOR PROMOTING DISAPPEARANCE OF ANTIGEN VIA FcyRHB (54) fg: FcyRIIB LTtaJ!(D>Ni££<£it\"f (57) Abstract: The invention provides: an antigen-binding molecule containing (i) an antigen-binding domain for changing the binding activity in relation to an antigen depending on the conditions of ion concentration, (ii) an Fcy-binding domain having FcyRIIb selective binding activity, and (iii) an FcRn-binding domain having binding activity in relation to FcRn under the condi - tions of pH acidic a region; and a method for lowering the concentration of an antigen in the plasma in comparison with before ad - ministration of the molecule, the method comprising administering the molecule. (57) (ii) FcyRIIb h Fey -f >, & b tflC(iii) pH UttiiCD^T FcRn -g> *> FcRn*s^ -r > fee tzttimm=t-v>n ^ flfr <t itK L T ^ataJS© JfiL« + »JS S<£T $ -a- S ^ SS o