Patent SG-11201408397S-A (SG)
Title: Substituted thiophene- and furan-fused azolopyrimidine-5-(6h)-one compounds
Inventor: BRANSTETTER BRYAN
IPC: A61K31/519
Filed: 2013-06-18
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 December 2013 (27.12.2013) WIPOIPCT (10) International Publication Number WO 2013/192225 A1 (51) International Patent Classification: C07D 495/14 (2006.01) A61P 25/00 (2006.01) A61K31/519 (2006.01) A61P 9/00 (2006.01) (21) International Application Number: PCT/US2013/046403 (22) International Filing Date: 18 June 2013 (18.06.2013) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 61/661,091 18 June 2012 (18.06.2012) US (71) Applicant: DART NEUROSCIENCE (CAYMAN) LTD; 4th Floor, Queensgate House 113 South, Church Street P.O. Box 1994, Grand Cayman, KYI 1104 (KY). (72) Inventor; and (71) Applicant (for GD only)-. BREITENBUCHER, James [US/US]; 2433 North Summit Circle Glen, Escondido, CA 92026 (US). (72) Inventors: BRANSTETTER, Bryan; 4747 Marina Dr, #3, Carlsbad, CA 92008 (US). DYCK, Brian; 9242 Pebblestone Lane, San Diego, CA 92126 (US). GOMEZ, Laurent; 13270 Russet Leaf Lane, San Diego, CA 92129 (US). HUDSON, Andrew, Richard; 3110 Laurel St., San Diego, CA 92104 (US). MARRONE, Tami, Jo; 6420 Ruby Way, Carlsbad, CA 92011 (US). YICKERS, Troy; 10955 Lyra Ct„ San Diego, CA 92126 (US). PETERS, Marco; 4567 Louisiana Street, San Diego, CA 92116 (US). (74) Agent: MILLER, Kimberly, J.; Knobbe Martens Olson & Bear LLP, 2040 Main Street, 14th Floor, Irvine, CA 92614 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, [Continued on next page] (54) Title: SUBSTITUTED THIOPHENE- AND FURAN-FUSED AZOLOPYRIMIDINE-5-(6H)-ONE COMPOUNDS CJ CJ CJ o\ i-H cn i-H o CJ O £ o* flMft N 0» £ i.i... o FIG. 1 (57) Abstract: Described herein are compounds and chemical entities of Formula (I), methods of their synthesis, compositions comprising them, and their use in treating numerous diseases and dis­ orders, including cognitive deficits associated with CNS diseases and disorders. Pdelb WO 2013/192225 A11 lllll llllllll II llllll III lllll lllll III III III lllll lllll lllll lllll lllll llll llll lllllll llll llll OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, — UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))