Patent SG-11201810455X-A (SG)
Title: Methods for making ultrasound contrast agents
Inventor: ROBINSON SIMON
IPC: A61K49/22
Filed: 2017-07-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111 11111 0 11101 010 11111 01 10001101 110111111 100 HO 110 11110 HOED Organization International Bureau (10) International Publication Number (43) International Publication Date .....0 WO 2018/009570 Al 11 January 2018 (11.01.2018) W I PO I PCT (51) International Patent Classification: Charles, Chester [US/US]; 116 Essex Street, Beverly, MA A61K 49/22 (2006.01) 01915 (US). (21) International Application Number: (74) Agent: TREVISAN, Maria, A.; Wolf, Greenfield & Sacks, PCT/US2017/040755 P.C., 600 Atlantic Avenue, Boston, MA 02210-2206 (US). (22) International Filing Date: (81) Designated States (unless otherwise indicated, for every 05 July 2017 (05.07.2017) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (25) Filing Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (26) Publication Language: English DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (30) Priority Data: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, 62/359,181 06 July 2016 (06.07.2016) US KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 15/461,469 16 March 2017 (16.03.2017) US MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 15/602,580 23 May 2017 (23.05.2017) US OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (71) Applicant: LANTHEUS MEDICAL IMAGING, INC. TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. [US/US]; 331 Treble Cove Road, North Billerica, MA (84) Designated States (unless otherwise indicated, for every 01862 (US). kind of regional protection available): ARIPO (BW, GH, (72) Inventors; and GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (71) Applicants: ROBINSON, Simon, P. [GB/US]; 22 Kettell UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, _ Plain Road, Stow, MA 01775 (US). SIEGLER, Robert, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, W. [US/US]; 52 Moore Street, Chelmsford, MA 01824 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, = (US). NGUYEN, Nhung, Tuyet [US/US]; 5 Landmark MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Road, Westford, MA 01886 (US). ONTHANK, David, C. TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, = [US/US]; 21 Kirk Farm Road, Groton, MA 01450 (US). KM, ML, MR, NE, SN, TD, TG). — = ANKLEKAR, Tarakeshwar, Vishwanath [US/US]; 109 = Pinehurst Avenue, Billerica, MA 01821 (US). VAN KIRK, = = Title: METHODS FOR MAKING ULTRASOUND CONTRAST AGENTS (54) = = FIG. 2 = = PG PG PG PG PG = +DPPC +DPPC + DPPC + DPPC — = + MPEG5000 + MPEGS000 + MPEG5000 = DPPE DPPE DPPE = + DPPA + CIPPA = +11.1 1.1g Ca+ 2 /g = I im fa- , 601. .. t NM aim` • — 11 /\".4°A art. . . , 4 4 oz__ OC.,, kn . , / OE --, . ' - 48- - I \" i ° ' S .' . \" . . t - 4 ' 9 7 : - - . . . . .-: ' ''.1a'.- 7 -2 __ . . - . - . . \" -.M'•:_*1 --- © CI , t ;. / . ir) ,............ -......::::__p- ..........7 `,....._ ..._.? _.:;:\"; _ _ 0 0 --.... Il N (57) : Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formu- lations. [Continued on next page] WO 2018/009570 Al MIDEDIMOMMIONERIONMENNEHOMMOIS Published: — with international search report (Art. 21(3))