baber/WOPTO huggingface dataset:
Patent JP-H11503643-A (JP)
Title: 点滴カテーテル差込み用安全スタイレット
IPC: A61M25/06
Filed: 1995-04-17
Abstract: (57)【要約】
カテーテル差込み装置(10)はスタイレット(12)を有し、そのスタイレット(12)はそれより延在した針(14)を備えている。カテーテル(16)は、針(14)を取り囲んでいるカニューレ(20)と、スタイレット(12)の先端部に設けられたアライメント部材(24)に支持された接続ハブ(22)とを有している。スプリング(44)は、針(14)を後方へ付勢する力を針(14)に対して付加している。解放自在なラッチ機構を備えた針保持部材(14)が、スプリング(44)の後方付勢力を抑制して針(14)を突出させた状態に保持するべくスタイレット(12)内に配置されている。カテーテル(16)を患者の血管内に差込んだ後に、スタイレット(12)の後部より突出している作動部材(64)に所定の圧力を付加する。作動部材(64)がラッチ機構を解放し、針(14)がスプリング(44)によって押されてスタイレット(12)の内部キャビティ(72)内に永久的に留められる。
Patent JP-2002503090-A (JP)
Title: 発酵における細胞収量の増加のための栄養培地
IPC: C12N1/14
Filed: 1997-06-17
Abstract: (57)【要約】
発酵において使用される、細胞または微生物の収量を増加させるための栄養培地を提供する。提供された処方は真菌類Lagenidium giganteumの収量を公知の培地の２〜３倍に増加させる。
Patent JP-2000503778-A (JP)
Title: 打楽器
IPC: G10K1/072
Filed: 1996-08-02
Abstract: (57)【要約】
本発明は楽器に関し、ベル本体の形の音発生要素と、該ベル本体内に取り付けられる揺動型の槌と、腕を設けられ、該槌を変位する駆動装置と、ベースとからなる打楽器に関する。ベル本体振動消音器と、該ベース上に配置されたターンテーブルと、該槌を変位する駆動腕上に配置される槌把持手段とが該機器内に設けられ、該消音器と該槌を変位する駆動装置腕は角度変位可能に該ターンテーブル上に設けられる。
Patent JP-H10511060-A (JP)
Title: 自動的に係合及び脱係合するギアボックス集合体
IPC: F16H48/12
Filed: 1996-05-24
Abstract: (57)【要約】
子供が乗るおもちゃにおける複数車輪（３４，３６）に取り付けられた被駆動軸シャフト（３２）に非回転的に同心的に装着されている出力ギア（６０）を自動的に係合しそして脱係合するためのギアボックス集合体が記述される。この集合体は複数の被駆動ギア（４４，４８，５２）を駆動するピニオン（４２）を有した電気モータ（５６）と、二つの位置の間を枢動でき前記複数の被駆動ギアの少なくとも一つのためのマウントを提供するヨーク（７０）とを含む。一つの位置においては、ヨークは出力ギア（６０）を枢動係合させ乗物の車輪を駆動し、他の位置においては、ヨークは出力ギアを枢動脱係合させこれにより乗物の車輪が自由に回転するのを許容しモータあるいは他のギアを駆動または逆駆動することはない。好ましい実施例においては、ヨークは一規定軸線のまわりに回転するように重りでバランスされる。別の実施例においては、ヨークは被駆動ギアの一つとの間に摩擦を発揮させてヨークを係合位置へ回動させる摩擦部材（７２）を含む。
Patent JP-H11503676-A (JP)
Title: ルーフィングガンのチンタグ供給用アタッチメント
IPC: B25C1/00
Filed: 1996-05-31
Abstract: (57)【要約】
釘打機用チンタグ供給装置はチンタグ供給溝を有する支持部材と、支持部材内にスライド可能に配置された往復板と、複数の積み重ねられたチンタグを収容する円筒容器と、円筒容器上にスライド可能に載置されたスライド部材と、スライド部材を往復板と接続するリンク組み合せと、装置を釘打機に接続する取付板とを含んでいる。釘打機を持ち上げると、スライド部材は円筒容器に沿って上方へスライドして、リンクを介して往復板をチンタグ供給溝内に静止している１個のチンタグと係合させて釘打ち部へ転位させ、釘打機から射出されるファスナーにより突き通されるまでチンタグはそこへ保持される。
Patent JP-2001512976-A (JP)
Title: トランスジェニックにより産生された非分泌性タンパク質
IPC: A61P3/10
Filed: 1998-02-24
Abstract: (57)【要約】
本発明は非分泌性タンパク質を作り分泌する方法を提供する。その方法には、(a)乳腺上皮特異的プロモーター；(b)タンパク質の分泌を指示し得る、乳汁タンパク質特異的シグナル配列；(c)場合により、トランスジェニック哺乳動物の乳汁に非分泌性タンパク質を分泌させるための、分泌性タンパク質のアミノ末端コーディング領域の十分な部分をコードする配列；および(d)非分泌性タンパク質をコードする配列を含み、要素(a)、(b)、場合により(c)、および(d)が好ましくは、列挙した順序で機能的に連結されているような核酸構築物から、タンパク質を発現させることが含まれる。細胞質タンパク質である、グルタミン酸脱炭酸酵素（GAD）およびミエリン塩基性タンパク質（MBP）の両方を、本発明の方法により作った。本発明は、本発明の方法を用いて産生したタンパク質を用いて糖尿病および多発性硬化症を治療する方法をも提供する。
Patent JP-2001521371-A (JP)
Title: ストレプトコッカス・ニューモニアエのチロシルｔＲＮＡシンセターゼ
IPC: A61K39/00
Filed: 1997-04-18
Abstract: (57)【要約】
本発明は、ｔｙｒＳポリペプチドおよびｔｙｒＳポリペプチドをコードするＤＮＡ（ＲＮＡ）、ならびに組み換え法によるかかるポリペプチドの製造方法を提供する。抗細菌化合物のスクリーニングのためのｔｙｒＳポリペプチドの使用方法も提供する。
Patent JP-2000509805-A (JP)
Title: タンカーでの油輸送中油留分を凝縮させるための冷却装置
IPC: F25D17/02
Filed: 1997-05-06
Abstract: (57)【要約】
冷却剤を冷却して冷温消費器へ供給した後、その冷却剤を戻される冷凍機（１８）を備えた冷却プラント。本発明によれば、冷凍機（１８）内で冷却された冷却剤を収集するための貯留タンク（２０）と、冷温消費器から加熱された冷却剤を収集するための戻しタンク（２２）から成る。
Patent JP-2001521582-A (JP)
IPC: C25D3/44
Filed: 1998-04-15
Abstract: The invention is directed to an electrolyte for the electrolytic high-speed deposition of aluminum on continuous products, containing an organometallic aluminum complex of formula (I)whereinM=K, Rb, Cs,R=a C3 alkyl group or a mixture of a C3 and a C1-C2 alkyl group,n=from 0.1 to 1,in an aromatic or aliphatic hydrocarbon as solvent.
Patent MD-20020063-A (MD)
Title: Compound for protection against radiation
Inventor: KOVALCOV MIHAIL
IPC: G12B17/02
Filed: 2002-02-04
Abstract: The invention relates to the compounds protecting from electromagnetic radiation, in particular generated by the industrial and household equipment. Summary consists in that the compound represents water treated at the temperature of 37,7 degree C with direct electric current with the density 1,5 A/dm2, wherein in the treatment process there is introduced selenium.The result of the invention consists in that after application and drying of the compound onto the equipment surface, the intensity of the magnetic field is decreased by 80%.Claims: 1
Patent MD-20030158-A (MD)
Inventor: POPEL SVETLANA
IPC: C07H1/08
Filed: 2003-06-26
Abstract: Inventia se refera la industria alimentara, si anume la procedeele industriale de extragere a substantelor indulcitoare din planta Stevia Rebaudiana Bertoni. Esenta inventiei consta in faptul ca amestecul dulce de glicozide din stevie se obtine in forma de extract in care surplusul de calciu, format in urma purificarii prin adaugarea oxidului de calciu sau hidroxidului de calciu, se inlatura sub forma de fosfati greu solubili, cu ajutorul acidului ortofosforic, la valoarea pH-lui 8,6 ± 0,4. Procedeul propus permite obtinerea extractului de stevie cu un inalt grad de curatare de saruri de calciu. ŕ
Patent MX-153043-A (MX)
Inventor: ANSON DONALD
IPC: F22G5/00
Filed: 1981-01-19
Abstract: An entrained bed combustor may provide constant temperature, superheated steam to a power generating steam turbine independent of the load on the turbine. In a conventional utility boiler heat is transferred in series to the steam generator, superheater and reheater. With the present invention these components may be run in parallel with heat transfer from the entrained bed particles enabling faster start-up and a turn-down capability without a reduction in the superheated steam temperature.
Patent MX-153002-A (MX)
Inventor: FRASSANITO JOHN ROBERT
IPC: A47K5/06
Filed: 1981-04-02
Abstract: An apparatus and package for liquid or granular materials includes two pivotally mounted dispensing blocks associated with a dispensing arm, whereby upon application of an actuating force to the dispensing arm, a resilient tube of the package is pinched shut by one dispensing block and the other dispensing block opens a slit diaphragm valve disposed within the resilient tube.
Patent MX-153921-A (MX)
Inventor: GINGERICH DAVID JOHN
IPC: H01H9/04
Filed: 1983-12-14
Abstract: A switch has a dielectric frame (14) carrying a series of contact members (16, 18), with aligned pair of contacts (16A, 18A) disposed at an upper surface and terminal sections (22) projecting from the frame, a movable contact member (34) pivotally mounted on one of the contacts of each pair, a housing (48) mounted on the frame and a movable actuating member (50, 52) associated with respective contact members (34) to move them to connect and disconnect contacts (16A, 18A). The actuating members (50, 52) are slidable and carry spring members slidably engaging the housing (48) and respective members (34). A membrane (42) is sealingly secured to the frame to cover the contacts (16A, 18A) and member (34).
Patent MX-162794-A (MX)
Inventor: RANA MAHENDRASINH DOLATSINH
IPC: C22C38/18
Filed: 1984-05-18
Abstract: A precisely defined steel alloy particularly suited to gas storage cylinder manufacture, and a gas storage cylinder manufactured thereof which exhibits remarkably improved performance over conventional gas storage cylinders.
Patent NZ-198688-A (NZ)
Title: Wallpaper scarifying roller:inclined and angled pair of rotatable gripping discs
Inventor: BROOKFIELD P A M
IPC: B44C7/02
Filed: 1981-10-19
Abstract: A wallpaper scarifying tool (10) has a plurality of modules (11), each module (11) consisting of a pair of cutter discs with bevelled teeth, rotatably mounted at an angle to the direction of travel to provide a sideways tearing action on wallpaper as the discs are moved along the surface of the wallpaper. Each module is mounted independently, to provide an independent suspension having several degrees of freedom. Adjustable depth control is provided by moving the discs relative to wall contacting members to vary the depth of penetration of the cutters below the skids.
Patent NZ-217523-A (NZ)
Title: Parturition monitor measures abdominal contractions
Inventor: COBBEN ANDREE
IPC: A61B5/00
Filed: 1986-09-10
Abstract: A monitoring belt which comprises at least one sensing element acting in the longitudinal direction of deformation of the belt enables abdominal muscular activity to be detected. The sensing element is connected to an electronic circuit for evaluation, treatment and/or recording of data supplied by the sensing element. The resultant evaluation enables an alarm or safety system to be triggered.
Patent NZ-221066-A (NZ)
Title: Trichokirin and derivatives
Inventor: BARBIERI LUIGI
IPC: A61K38/00
Filed: 1987-07-14
Abstract: The present invention relates to a novel glycoprotein, extracted from the seeds of Trichosanthes kirilowii, called: trichokirin, as well as to its modified derivatives containing a free or blocked SH group. It relates to a process for its preparation, to its use and to pharmaceutical compositions in which it is present.
Patent NZ-223126-A (NZ)
Title: Process making an alcoholic beverage
Inventor: COLIN GERARD
IPC: C12G3/02
Filed: 1988-01-07
Abstract: PCT No. PCT/FR87/00523 Sec. 371 Date Aug. 29, 1988 Sec. 102(e) Date Aug. 29, 1988 PCT Filed Dec. 30, 1987 PCT Pub. No. WO88/05084 PCT Pub. Date Jul. 14, 1988.This process consists in taking vegetal juice obtained by pressing at least one vegetal substance, adjusting its pH before sulfiting it, clarifying it, then subjecting it to microfiltration through a membrane. The microfiltered juice is subjected to controlled alcoholic fermentation in a carbon dioxide atmosphere. This process results in new alcoholic drinks having very pleasant organoleptic properties. An installation for industrially carrying out the process applied to cane sugar results in cane wine and pure cane spirit.
Patent NZ-224872-A (NZ)
Title: Method of synthesising a crystalline silicate having the structure of zsm-11
Inventor: MCWILLIAMS J P
IPC: B01J29/06
Filed: 1988-06-02
Abstract: A crystalline silicate having the structure of ZSM-11 is synthesized from a reaction mixture comprising a source of alkali metal cations (M), a source of silicon, octylamine (R), seed crystals of ZSM-11 and water, and having a composition, in terms of mole ratios, within the following ranges: <TABLE> a
Patent NZ-228216-A (NZ)
Title: Tetrahydroimidazo(4,5,1-jk)(1,4)benzodiazepinone derivatives and antiviral compositions
Inventor: RAEYMAEKERS ALFONS HERMAN MARG
IPC: C07D487/06
Filed: 1989-03-03
Abstract: Novel antiviral tetrahydroimidazo[1,4]benzodiazepin-2-ones of formula   <CHEM> a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein R<1> is hydrogen, C1-8alkyl, C3-6alkenyl, C3-6alkynyl, C1-6alkylcarbonyl, C3-6cycloalkyl, or substituted C1-6alkyl;  R<2> is hydrogen, C1-6alkyl or C3-6alkenyl  R<3> is hydrogen or C1-6alkyl; R<4> is hydrogen; substituted C1-6alkyl; C1-6alkylcarbonyl; C3-6alkenyl; C3-6cycloalkyl; C5-6cycloalkenyl;  R<5> is hydrogen, C1-6alkyl or halo; and  aryl is optionally substituted phenyl; pharmaceutical compositions containing these compounds as active ingredient; processes for preparing said compounds and compositions.
Patent NZ-236386-A (NZ)
Title: Protective coatings for portland cement concrete
Inventor: BREDOW CHARLES WILLIAM
IPC: C04B26/14
Filed: 1990-12-07
Abstract: The invention concerns a composition which may be used in or as a composition for coating or overlaying Portland cement concrete or metal. The composition includes a synthetic polymer latex, an amine-functional epoxy curing agent and an epoxy-functional or amine-functional silane. The composition may additionally comprise an epoxy resin and a filler having a fine particle size.
Patent NZ-238180-A (NZ)
Title: Water-soluble film with an outer layer of water-soluble polymeric material, and an inner layer consistent with a packaging purpose for which the film is to be used
Inventor: VAN PUTTE ANDREW W
IPC: B65D65/40
Filed: 1991-05-17
Abstract: A water soluble film suitable for packaging caustic chemicals has an outer layer of a water soluble polymeric material, and an inner layer of a polymeric material which is compatible with the contents of a package made from the film. An intermediate layer can optionally be included to contribute to the tensile strength, bulk, or abuse resistance, or some other property of the film. Water soluble fillers such as salt can optionally be added to one or more of the polymeric materials, prior to or during extrusion of the film, to improve the processability of the film or its rate of dissolution in water, or to add a pigment to the film.
Patent NZ-238238-A (NZ)
Title: 5h,10h-pyrido(3,4-b)pyrrolo(1,2-e)(1,4,5)oxadiazepine derivatives and pharmaceutical compositions thereof having analgesic activity
Inventor: EFFLAND RICHARD C
IPC: C07D498/14
Filed: 1991-05-23
Abstract: There are disclosed various compounds of the formula below, <CHEM>  where   X   is hydrogen, halogen or loweralkyl; Y   is hydrogen, halogen, loweralkyl, loweralkoxy or trifluoromethyl;   R1   is hydrogen, loweralkyl, aryl, arylloweralkyl, diloweralkylaminoloweralkyl or <CHEM>  R3 being hydrogen, loweralkyl or arylloweralkyl; and R2   is hydrogen, loweralkyl or arylloweralkyl; which compounds are useful as analgesic agents, and a process for their preparation.
Patent NZ-242757-A (NZ)
Title: 38 kd antigen of m. tuberculosis and plasmid for its expression
Inventor: MAHAVIR SING
IPC: A61B10/00
Filed: 1992-05-15
Abstract: The invention relates to a hybrid plasmid for the expression of an unfused 38 kDa antigen of Mycobacterium tuberculosis in E. coli, to E. coli as host of the hybrid plasmid and to the 38 kDa antigen. <IMAGE>
Patent NZ-248042-A (NZ)
Title: Particles of crystalline anti-cancer agent having a surface modifier adsorbed onto the surface thereof in an amount sufficient to maintain a particle size less than 1000 nm
Inventor: SARPOTDAR PRAMOD P
IPC: A61K9/107
Filed: 1993-07-01
Abstract: Dispersible particles consisting essentially of a crystalline anticancer agent having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 1000 nm. Anticancer compositions comprising the particles exhibit reduced toxicity and/or enhanced efficacy, and can be administered by intravenous injection.
Patent NZ-254392-A (NZ)
Title: Pharmaceutical compositions comprising a sphingoid (e.g. ceramide) compound and optionally cholesterol and a fatty acid
Inventor: ELIAS PETER M
IPC: A61K8/00
Filed: 1993-06-18
Abstract: PCT No. PCT/US93/05798 Sec. 371 Date Feb. 27, 1995 Sec. 102(e) Date Feb. 27, 1995 PCT Filed Jun. 18, 1993 PCT Pub. No. WO94/00127 PCT Pub. Date Jan. 6, 1994Disorders of the skin and mucous membrane that have a disrupted or dysfunctional epidermal barrier are treated or prevented by topical application of a formulation comprising certain of the three major epidermal lipid species or their structurally similar precursors, isomers, or analogs in certain proportion ranges. This invention utilizes the following lipid species in unique combinations of two or more components: cholesterol, an acylceramide, a ceramide, and essential and nonessential fatty acids. These combinations are effective both as moisturizing agents and agents for the restoration of barrier function. Some of these combinations are further enhanced by the addition of known moisturizers such as petrolatum and glycerine.
Patent NZ-285221-A (NZ)
Title: Vertical staged polycondensation reactor: trays with split liquid flow reversed each side
Inventor: YOUNT THOMAS LLOYD
IPC: B01D3/20
Filed: 1995-04-21
Abstract: This invention relates to a vertically disposed polymerization reactor having a series of essentially circular tray assemblies; each tray assembly having a central open vapor chimney and two split-flow paths each split-flow path containing one reverse flow path wherein the liquid polymer flow is reversed by means of a substantially semi-circular turnaround region; each tray having a liquid polymer tray inlet and a liquid polymer tray outlet for conducting a flow of the liquid polymer by means of a hydraulic gradient; each tray assembly being open at the top for escape of vapor from the liquid polymer flow to the central open vapor chimney; and each tray arranged in vertical disposition one above the other.
Patent NZ-290906-A (NZ)
Title: Can stack inter-tier paperboard divider strip: separable pads accomodate number of cans divisible by 2, 3 or 4
Inventor: CAMPBELL GEOFFREY
IPC: B65D71/70
Filed: 1995-08-09
Abstract: PCT No. PCT/GB95/01876 Sec. 371 Date May 27, 1997 Sec. 102(e) Date May 27, 1997 PCT Filed Aug. 9, 1995 PCT Pub. No. WO96/05120 PCT Pub. Date Feb. 22, 1996A divider panel for stacked cans is disclosed. The divider panel has an elongate paperboard strip (10) which includes a plurality of divider pads (12), each divider pad providing two rows of can seats (11) defined therein for being disposed between two layers of vertically stacked cans. The divider pads are connected along their ends to adjacent ones of the divider pads along perforated lines (13) to assist in separating the divider pads from one another as desired. The use of the elongate divider panel of this invention allows for lower operating speeds in placing the divider panel on a generally continuous lower layer of cans prior to placing the upper layer of cans thereon as the divider panel and the cans move along a path of travel on a packaging machine when compared to sequentially placing one of a series of separate divider pads between the pairs of cans otherwise being moved along the path of travel on the packaging machine at a relatively faster rate of speed. The divider panel of this invention can be used with a variety of arrays of cans.
Patent NZ-296019-A (NZ)
Title: Aminotetrazol derivatives, preparation and pharmaceutical compositions thereof
Inventor: HALLINAN ANN E
IPC: C07D277/46
Filed: 1995-11-08
Abstract: Compounds having formula (I) and pharmaceutically acceptable salts thereof, wherein B is NR<5>R<11>, wherein R<5> is selected from the group consisting of hydrogen, lower alkyl, lower alkenyl, lower alkynyl and aryl, and R<11> is selected from a 3 to 8 member heterocyclyl radical in which at least one member of the ring is carbon and in which 1 to about 4 members are heteroatoms independently selected from oxygen, nitrogen and sulfur and said heterocyclyl radical may be optionally substituted, useful as nitric oxide synthase inhibitors. <CHEM>
Patent NZ-304321-A (NZ)
Title: Ophthalmic lens and polymer composition therefor comprising at least one oxyperm polymerizable material and at least one ionoperm polymerizable material
Inventor: NICOLSON PAUL CLEMENT
IPC: C08K3/00
Filed: 1996-03-22
Abstract: An ophthalmic lens is disclosed which is suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of an oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.
Patent NZ-330123-A (NZ)
Title: Waste outlet for shower cabinet, includes water trap and filter
Inventor: KNIGHT RODNEY PAUL
IPC: E03C1/22
Filed: 1998-04-03
Abstract: A waste outlet of the type described comprises a bowl 2 with a drainage outlet 4 which is capable of connection to a waste pipe, means 6, 8 to locate bowl 2 in relation to the surface to be drained and a removable drainage cover 24 for bowl 2.  A waste trap 16 is in bowl 2 and a lift-out filter means 44 is in the trap.
Patent NZ-334528-A (NZ)
Title: Mattress coil springs each enclosed within individual fabric pockets having flat overlapping side seams
Inventor: KUCHEL BERNHARD WALTER
IPC: A47C23/053
Filed: 1997-09-08
Abstract: Apparatus for constructing strings of coil springs is disclosed.  Each spring is enclosed within individual fabric pockets having flat overlapping side seams.  The apparatus comprises a fabric in-feed mechanism having means for folding a flat web of fabric a first time to define a first flap A and means for folding the web a second time to define a second flap B underlying flap A thereby defining a fabric tube 33 having a flap side and a back side 62.  The apparatus further comprises means 72 for separating flap A from flap B to form an opening between the flaps; a coil spring inserter 72 to insert a compressed coil spring 16 through the opening into the tube; means for closing the opening; and means for interconnecting the closed first and second flaps.
Patent NZ-500212-A (NZ)
Title: (S) 2-methylamino-2-phenyl-n-butyl 3,4,5-trimethoxybenzoate and its application to the treatment of chronic pain
Inventor: DAHL SVEIN GUNWALD
IPC: A61K31/216
Filed: 1998-06-23
Abstract: Optically pure (S) 2-methylamino-2-phenyl-n-butyl 3,4,5-trimethoxybenzoate having formula (I) is provided.  (S) 2-formylamino-2-phenyl-n-butyric acid is reduced with a hydride derived from boron in order to obtain (S) 2-methylamino-2-phenyl-n-butanol, which is then esterified with a reagent chosen from 3,4,5-trimethoxybenzoyl chloride or methyl 3,4,5-trimethoxybenzoate in order to obtain the compound of formula (I). The compound of formula (I) may be used in pharmaceutical compositions for the treatment of chronic pain.
Patent NZ-505339-A (NZ)
Title: Camptothecin tetracyclic derivatives useful for inhibiting topoisomerase I and/or II pyridine intermediates thereof
Inventor: BIGG DENNIS
IPC: A61P43/00
Filed: 1998-12-16
Abstract: Tetracyclic analogues of camptothecin of formula (I), their preparation processes, their use as medicaments and the pharmaceutical compositions containing them, where: R1, R2, R3, R4, R5 and R10 are as described in the specification. These Tetracyclic analogues of camptothecin, which include in particular 3-hydroxy-3-(4-oxo-4,6-dihydroindolizino [1,2-b] quinoline-2-yl)pentanoic acid, have a powerful biological activity inhibiting topoisomerase I and/or topoisomerase II.
Patent NZ-505985-A (NZ)
Title: Human DNase I variants with a lower binding affinity for actin that native human dnase
Inventor: LAZARUS ROBERT A
IPC: C12N15/55
Filed: 2000-07-26
Abstract: A variant of human DNase I having DNA hydrolytic activity, and binding affinity for actin which is less than the binding affinity for actin of native DNase I.  The variant has at least one of the following amino acid substitutions: D53R, D53K, D53Y, D53A, Y65A, Y65E, Y65R, V67E, V67K, E69R, or H44A.
Patent NZ-508494-A (NZ)
Title: Composition having low thermal resistivity and method for laying underground cables for carrying electrical energy
Inventor: CASLINI DANILO
IPC: C04B20/00
Filed: 1999-05-26
Abstract: The present method relates to a system for carrying electrical energy in connections made by means of underground cables. In particular, it relates to a method of laying cables and a trench filler having a low thermal resistivity, used for laying underground cables for carrying electrical energy. More particularly, it relates to the use of an inert filler to be disposed in an area around the cables or the parts of the system, such as joints, which are disposed underground. The method of laying cables disposed in a trench comprises the phases of: removing the original soil in such a way as to prepare the said trench; disposing a first layer of a first composition in the said trench; disposing the said cables on top of the said first layer; disposing a second layer of the said first composition on top of the said cables; disposing a third layer on top of the said second layer formed by a second composition in such a way as to fill the said trench; characterized in that the said first composition comprises: 60-90 % by weight of crushed sand; 4-15 % by weight of silt; 2-12 % by weight of cement; 4-15 % by weight of water.