baber/WOPTO huggingface dataset:
Patent PT-729298-E (PT)
Inventor: SYNODIS JOSEPH
IPC: A61K8/22
Filed: 1994-11-02
Abstract: Denture cleanser tablet compositions are disclosed which include a flavoring agent in one layer and a bleaching agent in a second layer. This arrangement avoids deterioration of the tablet flavor and taste during storage.
Patent PT-739212-E (PT)
Inventor: SYKES MEGAN
IPC: A61K38/00
Filed: 1995-01-20
Abstract: The use of interleukin-12 to prevent, to ameliorate, and to treat graft-versus-host disease in a mammal in need of such treatment is disclosed.
Patent PT-821687-E (PT)
Inventor: CAPUDER EGIDIJ
IPC: C12P17/00
Filed: 1996-04-17
Abstract: Provided is a process for purification of clavulanic acid or a pharmaceutically acceptable salt or ester thereof, including adding an additional solvent to a solution of clavulanic acid in water immiscible solvent; contacting the solution with an amine; isolating the amine salt of the clavulanic acid formed; and converting the amine into clavulanic acid or a pharmaceutically acceptable salt or ester thereof.
Patent PT-910407-E (PT)
Inventor: NOUJAIM ANTOINE A
IPC: A61K39/395
Filed: 1996-05-15
Abstract: Disclosed are methods for treating cancer comprising administering a xenotypic antibody and a chemotherapeutic drug to a patient suffering from cancer. Also disclosed is a method for inducing a host immune response in a patient against a multi-epitopic in vivo tumor antigen present in the host serum, which antigen does not elicit an effective host immune response, comprising administering to the patient a chemotherapeutic drug and a composition comprising a binding agent that specifically binds to a first epitope on the antigen and allowing the binding agent to form a binding agent/antigen pair, wherein an effective host immune response is elicited against a second epitope on the antigen.
Patent PT-850925-E (PT)
Inventor: MAGNONE ANGELO GRATO
IPC: C11C3/14
Filed: 1997-12-23
Abstract: Photochemical isomerization of 11-cis-,13-cis-retinoic acid to 13-cis-retinoic acid characterized in that it is performed in an aqueous solution of an alkaline salt of said 11-cis-,13-cis-retinoic acid.
Patent PT-907885-E (PT)
Inventor: RUDEN THOMAS VON
IPC: C12Q1/66
Filed: 1997-06-25
Abstract: The invention concerns a method of comparative high-throughput screening of pharmacologically active substances. In one process step the substances are deposited on test cells that contain one or more biological target molecules, the cells having an identical biological base composition and differing in their target molecules, and/or are deposited on cells having a different biological base composition and identical target molecules. The effect of the substance on the activity of the target molecules is measured using a detection system linked to the activation of the target molecule and is compared directly with the effect on other molecules.
Patent PT-972218-E (PT)
Inventor: ROLLER THOMAS W
IPC: G02B6/38
Filed: 1998-03-31
Abstract: The proximal connector includes a stainless steel cone-shaped ferrule enclosing a proximal end of the optic fiber element. The ferrule is inserted within a matching aperture of a receiving block which is also made of stainless steel. The matching shapes of the ferrule and the aperture of the receiving block ensure effective heat transference from the ferrule into the receiving block. Both ferrule and the aperture are axially symmetric such that any rotation of the proximal connector while inserted into the receiving block does not change the location of the entrance aperture of the optic fiber element. The proximal connector also includes a case having an indented ring. A ball plunger biasing mechanism is mounted within the aperture of the receiving block and is positioned for engaging with the indented ring only while the proximal connector is fully and securely inserted within the aperture. The plunger prevents accidental removal of the proximal connector while also providing a biasing force for ensuring solid contact between the cone-shaped ferule and the corresponding portions of the receiving block to further facilitate the heat conduction.
Patent PT-1053011-E (PT)
Title: Mixed micellar pharmaceutical delivery system and method of preparation
Inventor: MODI PANKAJ
IPC: A61K38/22
Filed: 1999-02-05
Abstract: A mixed micellar pharmaceutical formulation includes a micellar proteinic pharmaceutical agent, an alkali metal C8 to C22 alkyl sulphate, alkali metal salicylate, a pharmaceutically acceptable edetate and at least one absorption enhancing compounds. The absorption enhancing compounds are selected from the group consisting of lecithin, hyaluronic acid, pharmaceutically acceptable salts of hyaluronic acid, octylphenoxypolyethoxyethanol, glycolic acid, lactic acid, chamomile extract, cucumber extract, oleic acid, linolenic acid, borage oil, evening of primrose oil, trihydroxy oxo cholanylglycine, glycerin, polyglycerin, lysine, polylysine, triolein and mixtures thereof. The amount of each absorption enhancing compound is present in a concentration of from 1 to 10 wt./wt. % of the total formulation, and the total concentration of absorption enhancing compounds are less than 50 wt./wt. % of the formulation.
Patent PT-1073608-E (PT)
Inventor: BERTSCH-FRANK BIRGIT
IPC: B01J8/02
Filed: 1999-03-31
Abstract: An aqueous solution of hydrogen peroxide is produced by direct synthesis from hydrogen and oxygen in the presence of a heterogeneous catalyst. According to the invention, a gas mixture comprising H2 and O2, essentially saturated or supersaturated with water (=containing fog) is fed into a reactor containing the catalyst. The volume ratio of the gas mixture fed in (standard liters per hour) to liquid removed (liters per hour) is adjusted to a value equal to or greater than 15,000, especially 20,000 to 50,000, and the gas mixture leaving the reactor is recycled after replenishment with H2, O2, and H2O vapor. Solutions with high H2O2 concentration can be obtained according to the invention without additional concentration.
Patent IE-780013-L (IE)
Title: Telephone circuit
IPC: H04M1/60
Filed: 1978-01-03
Abstract: A telephone amplifier and attenuator circuit comprising an amplifier and an attenuator inserted in the transmit channel and an attenuator inserted in the receive channel of a telephone set. The speech signals conveyed by the transmit and receive channels are detected and added together for forming a sum control signal. The transmit amplifier is controlled by the detected transmit signal and the two attenuators are controlled in opposite directions by the sum control signal. In the preferred embodiment, the amplifier and attenuators are formed respectively by a balanced modulator and by balanced modulators inserted in the loop of negative feed back amplifiers.
[US4162374A]
Patent IE-790194-L (IE)
Title: Pharmaceutical formulation
IPC: A61K33/243
Filed: 1979-02-01
Abstract: A stable, sterile aqueous solution of cis-platinum (II) diamminedichloride (cisplatin) in a sealed container such as an ampule or vial in unit dosage form suitable for intravenous administration to man has a concentration of cisplatin in the range of from 0.1 to 1.0 mgm/ml. and a pH in the range of from 2.0 to 3.0, preferably about 5.5. The solution can also contain sodium chloride and mannitol.
[GB2021946A]
Patent IE-810752-L (IE)
Title: Syringe
IPC: A61M5/24
Filed: 1981-04-01
Abstract: A syringe with a plunger reciprocable therein has a collapsible container removably attached to the discharge end of the barrel. The container can be collapsed by means of the plunger. The stroke volume of the plunger between displaced positions thereof corresponding to the container being empty and filled, respectively, is substantially equal to the volume of the container.
[US4312344A]
Patent FI-843932-L (FI)
Inventor: DAVIDOW LANCE STEVEN
IPC: C12N15/81
Filed: 1984-10-05
Abstract: Process for transformation of Yarrowia lipolytica, vectors useful therefor comprising DNA of a microbial vector and chromosomal DNA of Y. lipolytica and transformants comprising said vectors in E coli and Y lipolytica, and integrative shuttle vectors for Escherichia-Yarrowia transgeneric cloning. Said vectors or subclones thereof enable creation of Y. lipolytica cloning vectors into which specific or random segments of DNA can be inserted and the resulting vectors used to transform a suitable host microbe, especially Y. lipolytica, to improve the fermentation characteristics thereof and hence their industrial utilization. The methodology described permits the cloning of genes from a gene library of Y. lipolytica by complenentation with an integrating vector. Specifically claimed are the plasmid vectors pLD25, pLD28, pLD40 and pLD55, Y. lipolytica transformants containing pLD25 and pLD55, and an E. coli transformant containing pLD25.
Patent FI-844397-L (FI)
Inventor: BJOERKLUND EVERT GUNNAR
IPC: B65D6/26
Filed: 1984-11-08
Abstract: Method of manufacturing a box and an arrangement permitting the secure but separable connection of an edge part (4a) of a first component (4) to an adjacent edge part (5a) of a second component (5). Each edge part is provided with a number of means designed to produce the connection. The means (7a) for one of the edge parts (4a) and the means (8a) for the other edge part (5a) are so executed in respect to each other as to exhibit, irrespective of their direction or position lengthwise along the respective edge part, means which correspond to each other and interact with each other.
Patent IE-36717-L (IE)
Title: Simulated fires
IPC: F24C7/00
Filed: 1972-09-19
Abstract: A simulated fireplace assembly includes a housing having a fan located therein whose air flow axis is tilted upwardly, and a heating means. Air deflecting baffle plates are provided to divert the air stream from the fan into two streams, one generally vertical and the other horizontal; the horizontal stream passes the heating means and thence through an air-permeable front panel of the housing to heat the surrounding space, while the vertical air stream exists through an air-permeable top panel of the housing to activate portions of a flame simulator associated with an ornamental display of at least one log supported on the top of the housing.
[US3742189A]
Patent IE-821520-L (IE)
Title: Preparation of 2, 4-diamino-5-(3',4'-5'-trimethoxy-benzyl)¹pyrimidine
IPC: C07D239/49
Filed: 1982-06-25
Abstract: The invention relates to an improved process for the preparation of 2,4-diamino-5-(3',4',5'-trimethoxy-benzyl)-pyrimidine of the general formula I <IMAGE> by reacting a compound of the general formula II <IMAGE> (wherein R is an alkyl group having 1-4 carbon atoms) with guanidine, which comprises preparing the said compound of the general formula II by reacting alpha -(3,4,5-trimethoxy-benzal)- beta -methoxy-propionitrile of the formula III <IMAGE> with ethylene glycol monoalkylether of the general formula IV HO-CH2-CH2-OR (IV> (wherein R as as stated above) in the presence of an alkali metal alkoxide at a temperature between 60 DEG and 90 DEG and reacting the compound of the general formula II thus obtained - if desired without isolation - with guanidine in the presence of an alkanol having 4-8 carbon atoms. The advantage of the process is that it is economical and can be carried out with high yields even on industrial scale and provides a product of high purity. The compound of the formula I obtained is a known chemotherapeutical drug.
[GB2104508A]
Patent IE-45765-L (IE)
Title: Imidazoles and triazoles
IPC: C07D249/08
Filed: 1977-08-09
Abstract: Triazoles of formula: <IMAGE> wherein R1 is alkenyl, alkynyl or optionally substituted aralkyl; Y is =N-, R2 is cycloalkyl, alkyl or haloalkyl, and R3 is H, methyl or alkenyl, or esters, ethers, salts and metal complexes thereof. The triazoles have fungicidal and plant growth regulating activity.
[US4243405A]
Patent IE-851894-L (IE)
Title: Fuel briquettes.
IPC: A61P35/00
Filed: 1985-01-28
Abstract: A fuel briquette (10) comprises compacted moistened coal slack or dross particles (11) sealed in a waterproof combustible envelope (12). The particles (11) substantially fill the volume of the envelope.
Patent IE-891895-L (IE)
Title: 2-amino-7-hydroxytetraline ethers
IPC: C07C217/54
Filed: 1989-06-13
Abstract: 2-Amino-7-hydroxytetralin ethers of formula <IMAGE> in which R' denotes a methyl substituted by a carboxy or lower carbalkoxy group; a process for their preparation from 2-amino-7-hydroxytetralin, N-protection, O-alkylation and N-deprotection; N-protected intermediates; and use of the compounds I for the preparation of the corresponding phenylethanolaminotetralins.
Patent IE-901943-L (IE)
Title: Treatment of chlorophyllous plants
IPC: C05D5/00
Filed: 1990-05-30
Abstract: A dilute aqueous solution containing less than 80 g/l of magnesium hydrogen carbonate of formula Mg(HCO3)2 can be used for the curative treatment of plants attacked by magnesium deficiency or preventively as complementary magnesium fertilizer and as photosynthetic activator of growth of plants by simple spraying onto them. An aqueous solution of magnesium hydrogen carbonate Mg(HCO3)2 is prepared from MgO as starting material by mixing it into water and by treating the solution or suspension thus obtained with gaseous carbon dioxide, at a temperature below 40 DEG  C. under a pressure greater than 5x105 pascals (5 bars).
Patent IE-45709-L (IE)
Title: DIBENZ [b,f] AZEPINE DERIVATIVE.
IPC: A61P25/24
Filed: 1977-10-07
Abstract: 3-Cyano-N-(N,N-dimethylaminopropyl)-iminodibenzyl, and its salts, prepared, inter alia, by heating 3-cyano-iminodibenzyl-5-carboxylic acid (N,N-dimethylaminopropyl ester) are described. The end product and its salts are useful as antidepressants.
[US4138482A]
Patent IE-42448-L (IE)
Title: Power swivel assembly for drilling rig
IPC: E21B19/16
Filed: 1975-09-22
Abstract: 1493717 Boring earth &c WESTERN GEAR CORP 17 Sept 1975 [30 Sept 1974] 38204/75 Heading E1F A rotary drill head 28 which is vertically movable in a drilling rig includes a power unit 54 including motors 70 and which has a vertical opening through which drill pipe can be passed while being tripped, a stem assembly 50 adapted to occupy the opening and be driven by the power unit 54 and adapted to be connected drivingly to a drill pipe depending from its lower end. the stem assembly 50 being removable from the opening when disconnected from the drill pipe, and pipe holding means 57 for holding the drill pipe when the stem assembly 50 is removed. As described the drilling rig includes a mast having a fixed lower portion 30 and an upper extendible portion 30a and which is mounted on a base 10 which can move transversely along guides 12 and longitudinally along guides 14. The base 10 also carries a power tong 38 and power slips 39. A pipe rack 35 is carried by the lower portion 30 of the mast. The drill head 28 is connected to rods 26 depending from a cross head 22 which can be moved vertically by hydraulic rams 18, the drill head 28 being guided by rollers 59 engaging guides 60 on the rams 18. The drive unit 54 consists of a housing 53 carrying four motors 70 which drive an internally splined gear ring 72. The stem assembly 50 (Fig. 3) is removably secured to the housing 53 by wedges 52 and consists of a hollow shaft 62 having external splines 75 (which mate with the splines on the gear ring 72) and a threaded pin 63, the upper end of the shaft 62 being connected to a rotary swivel 68 and stationary pipe 66 for drilling fluid. When the stem assembly is removed, an entry guide 80 (Fig. 4) is installed in its place. The pipe holding means 57 include slips 84 operated by ram 87. When drilling, the rig is used in a conventional manner with the stem assembly 50 in place, single drill pipes being added to or removed from the string using the tongs 38 and slips 39. When tripping pipe into or out of the borehole the stem assembly 50 is replaced by the entry guide 80. Double lengths of pipe P (Fig. 2) can then be removed by holding the top of the pipe string in the slips 57, raising the drill head 28, holding the pipe string by the slips 39 whilst lowering the drill head 28, operating the slips 57 and raising the drill head 28 again so that a double length of pipe is withdrawn from the borehole, and then holding this double length by slips 39 and lowering the head 28. The double length of pipe is then located above the head 28 and can be removed and transferred to the pipe rack 35.
[GB1493717A]
Patent IE-772296-L (IE)
Title: Preparation of gamma-pyrones from substituted furans
IPC: C07D309/40
Filed: 1977-11-11
Abstract: Gamma-pyrones are prepared by contacting a 3-halo-furfuryl alcohol or a 3-alkoxy-furfuryl alcohol with one equivalent of a halogen, peracid or peroxide oxidant and then heating until hydrolysis of the formed 4-substituted-dihydropyran intermediate is substantially complete. Maltol (2-methyl-3-hydroxy-4H-pyran-4-one) is prepared by this process from 2-(1-hydroxyethyl)-3-alkoxy furans or 2-(1-hydroxyethyl)-3-halo-furans. Gamma-pyrones are also prepared by contacting the corresponding 3-substituted-2,5-dialkoxy-furfuryl alcohols with acid until conversion to the gamma-pyrones is substantially complete.
[CA1109478A]
Patent IE-872693-L (IE)
Title: Analogs of gonadoliberin
IPC: A61K38/00
Filed: 1987-10-08
Abstract: The invention relates to peptides of the formula  <IMAGE>  in which X is absent or is hydrogen or acyl; A is Pgl, de-hydro-Pro, Pro, D-Thi or D-Pgl or represents optionally substituted D-Nal(2), D-Phe or D-Trp; B is His or optionally substituted D-Phe; C is Trp, D-Thi, D-Pal(3) or optionally substituted D-Trp; D is Tyr, Arg of His; E is D-Ser(R1),  beta -Asn,  beta -Asp-OMe, D-Thi or -NH-CH(CH2R2)-CO-; F is Ser(R1), Leu, Trp or Phe; G is Gly-NH2, Aza-Gly-NH2, D-Ala-NH2 or NH-alkyl; R1 is glycosyl and R2 is hydrogen, acyl, aryl or heteroaryl. The invention also relates to methods for the preparation of these peptides, agents containing them and their use.
Patent IE-843167-L (IE)
Title: Connection for scaffolding
IPC: E04G7/30
Filed: 1984-12-10
Abstract: A device (4) for connecting a tubular horizontal member (3) to a tubular upright (2) in a scaffold (1) for building, in which the horizontal member (3) engages, by means of a fork (7), a tenon (6) provided laterally on the upright (2), while a mutually parallel bolt (14) and wedge (15) extend through the fork (7) and tenon (6) to lock the fork on the tenon.
Patent IE-873242-L (IE)
Title: Catechol derivatives
IPC: C07C49/84
Filed: 1987-11-30
Abstract: Pharmacologically active catechol derivatives of formula I <IMAGE> I wherein R1 and R2 independently comprise hydrogen, alkyl, acyl, optionally substituted aroyl, lower alkylsulfonyl or alkylcabamoyl or taken together form a lower alkylidene or cycloalkylidene, X comprises an electronegative substituent such as halogen, nitro, cyano, lower alkylsulfonyl, sulfonamido, aldehyde, caboxyl or trifluoromethyl and R3 comprises hydrogen, halogen, hydroxy alkyl, amino, nitro, cyano, trifluoromethyl, lower alkylsulfonyl, sulfonamide, aldehyde, alkyl carbonyl, aralkylidene carbonyl or carboxyl or a group selected from <IMAGE> wherein R4 comprises hydrogen, alkyl, cyano, carboxyl or acyl and R5 comprises hydrogen, cyano, carboxyl, alkoxycarbonyl, carboxyalkenyl, nitro, acyl, optionally substituted aroyl or heteroaroyl, hydroxyalkyl or carboxyalkyl or R4 and R5 together form a five to seven membered substituted cycloalkanone ring; -(CO)n(CH2)m-COR wherein n is 0-1 and m is 0-7 and R comprises hydroxy, alkyl, carboxyalkyl, optionally substituted alkene, alkoxy or optionally substituted amino; <IMAGE> wherein R8 and R9 independently comprise hydrogen or one of the following optionally substituted groups; alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, or together form an optionally substituted piperidyl group; -NH-CO-R10 wherein R10 comprises a substituted alkyl group.
[US4963590A]
Patent IE-873452-L (IE)
Title: Stable formulations of ricin toxin a chain and of¹rta-immunoconjugates and stabilizer screening methods¹therefor
IPC: A61K38/00
Filed: 1987-12-18
Abstract: Highly stable pharmaceutical compositions suitable for parenteral administration to animals or humans comprising a therapeutically effective amount of an RTA-immunoconjugate dissolved in an inert carrier method comprising a stabilizer are claimed. Screening methods for selecting stabilizers effective in preventing precipitation and aggregation of such compositions are described. Preferred stabilizers include glycerol at a concentration (v/v) of from about 25 to about 35%; dextran sulfates having molecular weights from about 0.1 x 10<6> to about 2 x 10<6> daltons; and human serum albumin. The invention further comprises such compositions which have been lyophilized and/or reconstituted wherein the stabilizer is non-volatile, and may further comprise a carbohydrate stabilizer. The invention further comprises stabilized RTA compositions.
[EP0271918A2]
Patent NO-820226-L (NO)
Inventor: HUTTUNEN JOUKO
IPC: C08B15/06
Filed: 1982-01-26
Abstract: An alkali-soluble cellulose derivative is produced by treating cellulose with liquid ammonia having urea dissolved therein, removing the ammonia, resulting in cellulose having urea distributed therethrough, and heating the thus obtained cellulose-urea to cause reaction between the urea and cellulose and form alkali-soluble cellulose carbamate. This cellulose carbamate can be precipitated from alkaline solution in the form of cellulose carbamate film or fibre.
Patent NO-840671-L (NO)
Inventor: MUELLER-TAMM HEINZ
IPC: C08F210/00
Filed: 1984-02-22
Abstract: 1. A process for the continuous production of particulate ethyl-ene/butene-1 copolymers catalytic polymerization of ethylene and butene-1 in a liquid alkane -in which the monomers to be polymerized are present in dissolved form, and the particulate copolymer formed is present in suspended form as reaction medium, using a Ziegler catalyst system consisting of (1) a titanium-containing component and (2) an aluminium trialkyl, in the presence of hydrogen as molecular weight regulator at elevated temperature and under elevated pressure, while circulating the reaction mixture in a loop to which the starting materials are added, and from which the particulate copolymer formed is removed, wherein, (a) isobutane is used as the reaction medium, (b) the amount of monomeric ethylene in the reaction mixture is kept within a range of 6 to 15 moles par 100 moles of the total molar amount of isobutane, monomeric ethylene, monomeric butene-1 and hydrogen contained in the reaction mixture, (c) the amount of monomeric butene-1 in the reaction mixture is kept within a range of 20 to 35 moles per 100 moles of the total molar amount of isobutane, monomeric ethylene, monomeric butene-1 and hydrogen contained in the reaction mixture, (d) the amount of hydrogen in the reaction mixture is kept within a range of 0.1 to 1.5 moles per 100 moles of the total molar amount of isobutane, monomeric ethylene, monomeric butene-1 and hydrogen contained in the reaction mixture.
Patent NO-840981-L (NO)
Title: Polypeptid-toksin hybrid-protein.
Inventor: BACHA PATRICIA
IPC: C07K14/34
Filed: 1984-03-14
Abstract: Hybrid-protein som er toksisk for celler som har lineære neuropeptid-reseptorer, for eksempel TRH-reseptorer som omfatter et lineært neuropeptid, for eksempel TRH kovalent bundet til CRM 45, er nyttig for behandling av tumorer.Fremstillingen av hybrid-proteinet er "beskrevet.
Patent NO-843432-L (NO)
Inventor: NICKS PETER FRANCIS
IPC: C09D5/02
Filed: 1984-08-29
Abstract: Aqueous coating compositions comprise a polymer of defined molecular weight which contains either anionisiable or cationisable groups and also certain defined non-ionisable water-soluble moieties (derived for example from polyethylene glycol), water, optionally an organic coupling solvent and optionally either base or acid. The presence in the polymer of regularly distributed ionisable groups and non-ionisable water-soluble moieties enables the selection of aqueous polymer solutions for use in coating compositions which, on dilution, show a regular relationship between viscosity and solids content. The polymer solutions are particularly useful in the formation of paints.