baber/WOPTO huggingface dataset:
Patent CO-6170364-A2 (CO)
Title: Novedosos anticuerpos que inhiben dimerizacion de c-met, y sus usos
Inventor: GOETSCH LILIANA
IPC: A61P35/00
Filed: 2010-02-12
Abstract: La presente invención se refiere a un proceso para la selección de anticuerpos anti c-Met capaces de inhibir tanto activación dependiente-de-ligando como independiente-de-ligando de c-Met. Más particularmente, el proceso se basa en la inhibición de la dimerización de c-Met. En otro aspecto, la presente invención se refiere a dichos anticuerpos y composiciones que comprenden a dichos anticuerpos para la preparación de un medicamento para tratar cáncer. Son también parte de la invención procesos y equipos de diagnóstico.1.- Proceso para la selección de un anticuerpo anti c-met o uno de sus "fragmentos divalentes" o "derivados", capaces de inhibir tanto activación dependiente de ligando como independiente de ligando de c-Met, caracterizado porque comprende las siguientes etapas:i) cribar los anticuerpos generados y seleccionar anticuerpos capaces de ligar específicamente a c-Met; ii) evaluar in vitro los anticuerpos selectos de la etapa i) y seleccionar anticuerpos capaces de inhibir al menos 50% de proliferación de células tumorales para al menos un tipo de tumor; y después iii) probar los anticuerpos selectos de la etapa ii) y seleccionar anticuerpos capaces de inhibir la dimerización de c-Met. 2.- Proceso de conformidad con la reivindicación 1, caracterizado porque la etapa iii) consiste en evaluar anticuerpos por análisis BRET en células que expresan tanto c-Met-RLuc/YFP y seleccionar anticuerpos capaces de inhibir al menos 30% de la señal BRET.3.- Un anticuerpo aislado, o uno de sus "fragmentos divalentes" o "derivados" funcionales, capaces de obtenerse por un proceso de conformidad con la reivindicación 1 ó 2. 4.- El anticuerpo de conformidad con la reivindicación 3, o uno de sus "fragmentos divalentes" o "derivados" funcionales, caracterizado porque comprende al menos una región de determinación de complementariedad CDR seleccionada de CDRs que comprenden la secuencia de aminoácidos SEQ ID Nos. 1 a 17 y 56 a 61. 5.- El anticuerpo de conformidad con la reivindicación 3, o uno de sus "fragmentos divalentes" o "derivados" funcionales, caracterizado porque comprende una cadena pesada que comprende al menos una CDR seleccionada de CDRs que comprenden las secuencias de aminoácidos SEQ ID Nos. 1 a 9 y 56 a 58.
Patent CO-6341505-A2 (CO)
Title: Metodo y discriminador para clasificar distintos segmentos de una señal
Inventor: FUCHS GUILLAUME
IPC: G10L11/00
Filed: 2011-01-07
Abstract: Para clasificar distintos segmentos de una señal que comprende segmentos de por lo menos un primer tipo y un segundo tipo, por ejemplo, segmentos de voz y de música, se clasifica la señal en un corto plazo (150) sobre la base de por lo menos un rasgo distintivo de corto plazo extraída de la señal y se entrega un resultado de clasificación de corto plazo (152). La señal se clasifica también en un largo plazo (154) sobre la base de por lo menos un rasgo distintivo de corto plazo y por lo menos un rasgo distintivo de largo plazo extraídos de la señal y se entrega un resultado de clasificación de largo plazo (156). Se combinan (158) el resultado de la clasificación de corto plazo (152) y el resultado de la clasificación de largo plazo (156) para proveer una señal de salida (160) que indica si un segmento de la señal es del primer tipo o del segundo tipo.
Patent CO-6390062-A2 (CO)
Title: Método para la operación cíclica de bancos de hornos de coque compuestos de cámaras de horno de coque del tipo \\\"recuperación de calor\\\"
Inventor: KIM RONALD M
IPC: C10B15/02
Filed: 2011-06-15
Abstract: La invención se refiere a un método para operar cíclicamente un dispositivo de hornos de coque, en donde el citado dispositivo comprende un número par de bancos de hornos de coque, incluyendo cada uno, a su vez, un número par de cámaras de horno de coque. Dispositivos de calderas se conectan corriente abajo de los bancos de hornos de coque, para el accionamiento de turbinas empleando los gases calientes de escape de los bancos de hornos de coque. De esta manera se obtiene energía. Las cámaras de horno de coque se deshornan y cargan en un ciclo exactamente definido, de modo que puede homogenizarse en el transcurso del tiempo la producción de gas caliente de escape.
Patent CO-6470858-A2 (CO)
Title: Composición tensioactiva reconstituida mejorada que contiene análogos de la proteína tensioactiva b (sp-b) y de la proteína tensioactiva c (sp-c)
Inventor: PIVETTI FAUSTO
IPC: C07K14/785
Filed: 2011-12-02
Abstract: Un agente tensoactivo pulmonar reconstituido que comprende un vehículo lipídico y una combinación de un polipéptido análogo a la proteína tensioactiva SPC nativa con un polipéptido particular análogo a la proteína tensioactiva SP-B nativa. Formulaciones farmacéuticas que contienen dicho agente tensioactiva, y su uso para el tratamiento o la profilaxis del RDS y de otros trastornos respiratorios.
Patent CO-7240402-A2 (CO)
Title: Un revestimento de pezonera
Inventor: ALVEBY NILS
IPC: A01J5/08
Filed: 2014-12-04
Abstract: Un revestimiento de pezonera para una pezonera tiene una forma longitudinal que se extiende a lo largo de un eje longitudinal (x). El revestimiento de la pezonera comprende un cuerpo cilíndrico (2) que tiene una longitud (L) y que define un espacio interior (21) para recibir el pezón. El cuerpo cilíndrico tiene una sección transversal de forma poligonal transversalmente al eje longitudinal a lo largo del cuerpo cilíndrico. La forma poligonal transversalmente al eje longitudinal define una pluralidad de porciones de esqueina y una pluralidad de porciones laterales, cada una conectando dos de dichas porciones de esquina. cada porción de esquina comprende una superficie interior orientada hacia el espacio interior y tiene un radio interior que se extiende desde el espacio interior hacia la superficie interior. El radio interior es igual para cada porción de esquina. por otra parte, el radio interior de cada una de las porciones de esqueina es de al menos 4 mm en una parte central de la porción de esquina.
Patent EP-1031475-A2 (EP)
Inventor: KELLER GERALD J
IPC: B60R21/26
Filed: 2000-02-07
Abstract: A vehicle occupant protection system has a sensor
(600, 620) for detecting an impending or actual rear
impact. Another sensor (300, 302) determines the
position of the vehicle occupant subsequent to the
rear impact in relation to structures within a
passenger compartment. Airbags (208, 208a, 500, 502,
504) provide an inflatable protective restraint for
the vehicle occupant in response to the position of
the vehicle occupant. A controller (302) generates a
control signal to activate the airbags.
Patent EP-1046919-A2 (EP)
Inventor: KUCHER ANDREAS
IPC: G01R19/165
Filed: 2000-04-05
Abstract: The circuit includes a first circuit unit for producing a current mirror using a first transistor (M1). Under low load curre at a power transistor (M2), the falling voltage is compared with a first reference voltage, and an undercurrent signal is produced the voltage falls below the reference. A second circuit unit limits the drain voltage of the power transistor to a maximum value under high load current. The power transistor is a DMOS transistor with n1-cells and the first transistor is a MOS transistor with n2-cells. The undercurrent signal is generated when the load current is less than or equal to Iref*n1 2.
Patent EP-1048292-A2 (EP)
Inventor: BORMANN ANGELIKA
IPC: A61P17/10
Filed: 2000-04-13
Abstract: Use of compositions in the form of emulsions containing  alpha -hydroxy and  beta -hydroxycarboxylic acids, along with one o more glucose- and oligoglyceride-based surfactants, for cleansing skin and for the treatment of acne, is new. The use of certain cosmetic and/or dermatological compositions in emulsion form is claimed for cleansing the skin or treati acne. The compositions comprise: (1) one or more  alpha -hydroxycarboxylic acid derivatives of formula (R')(R'')(OH)C-COOH (I) and/or one or more  beta -hydroxycarboxylic acid derivatives of formula (R')(R'')(OH)C-X-COOH (II); (2) one or more surfactants A based on glucose derivatives of formula (III); and optionally (3) one or more other surfactants B of formula R3-O-(CH2-CH(OR4)-CH2-O)n-R5 (IV). X = an aliphatic CH2 group, a cycloaliphatic CH group, an aromatic CH group or a CH(OH) group; R', R'' = H, 1-25C alkyl (optionally substituted by one or more COOH, OH, aldehyde or oxo groups), phenyl (optionally substituted by one or more COOH, OH or 1-25C alkyl groups), or the  alpha - or  beta -carbon atom forms 3-7C cycloalkyl together with R' and (optionally substituted by one or more COOH, OH, oxo or 1-25C alkyl groups); R = 1-24C alkyl; R1 = H or 1-24C alkyl; R2 = H or 1-24C acyl; R3-R5 = H, 8-24C fatty acid (which may be substituted by up to 3 OH groups); n = 2-8.
Patent EP-1065108-A2 (EP)
Inventor: IWAMOTO TATSUHIKO
IPC: B60R21/34
Filed: 2000-06-13
Abstract: The invention provides a structure of a front part of a
vehicle body that is simple and free from the risk of maloperation.
In the event of a collision between the vehicle and a pedestrian, a
projecting part sweeps the pedestrian by parts of his or her legs
lower than the knees in the event of a collision between the
vehicle and the pedestrian, causing the pedestrian to be thrown
over toward the vehicle, and after an energy-absorbing member has
absorbed impact energy exerted on the legs, the pedestrian is
caused to drop onto the top of a hood and protected from secondary
damage. In one specific example, a structure of a front part of a
vehicle body in which a bumper (9) is provided at a lower front
position of a hood (1) of the vehicle comprises a lateral
supporting member (7) provided in the front part of the vehicle
body and extending in the direction of vehicle width, an energy-absorbing
member (8) provided ahead of the lateral supporting
member (7), and a projecting part (12) provided at a lower part of
the bumper 9 in such a manner that a forward end of the projecting
part (12) juts out more frontward than the lateral supporting
member (7).
Patent EP-1063583-A2 (EP)
Inventor: THYSSEN MATTHIAS NORBERT
IPC: G06F3/14
Filed: 2000-06-20
Abstract: The arrangement has a work module (1) and at least one play module (2) with a data communications connection (6) between them. Each play module is connected to at least one output device (4). The work module produces a list with at least one sequence of events for at least one output device. The list is associated with an absolute time and the event(s) with a relative time. The work module transmits the list to the play module and the play module reads the data set and drives the output device connected to it accordingly. An Independent claim is also included for a method of controlling data output to at least two output devices.
Patent EP-1085165-A2 (EP)
Inventor: HAGEMANN ULRICH
IPC: E06C7/42
Filed: 2000-09-06
Abstract: The hedge ladder (1) is mounted readily detachable on the front side of a wheel barrow through quick-fit fasteners. The wheelbarrow with the ladder fitted thereon can be tilted about the bearing points (14) of the barrow by displacing the lever arms (6, 6') so that the wheel (10) is automatically lifted from the ground or pressed down onto the ground. The bearing and support points of the lever arms are fitted with spikes. The lever arms are adjustable independently of each other.
Patent EP-1086977-A2 (EP)
Title: Partially vulcanized shaped rubber composition and preparation of article, including tires, having a component thereof
Inventor: LICKES JEAN-PAUL
IPC: C08K5/548
Filed: 2000-09-11
Abstract: The invention relates to the preparation of a
partially vulcanized, pre-shaped rubber composition
comprised of at least one diene-based elastomer, amorphous
silica, coupling agent and liquid diene-based. The
partially vulcanized rubber composition is adhered to an
unvulcanized rubber substrate to form a composite thereof
and the resulting composite vulcanized to create an article
of manufacture. The composition may be a component of a
tire such as an apex (7), sidewall insert (8) or tread (6).
It may also be a component of an industrial rubber product
such as a conveyor belt, power transmission belt or a hose.
Patent EP-1085503-A2 (EP)
Inventor: MISU KATSUYA
IPC: G10L19/10
Filed: 2000-09-15
Abstract: A speech coding apparatus includes a pulse
position candidate table, inter-pulse distortion table,
first and second reference address tables, first and
second reference address table creation units, and
search table creation unit. The pulse position
candidate table stores the pulse position candidate of
each pulse. The inter-pulse distortion table stores a
distortion calculated every pulse interval. The first
reference address table creation unit regards the pulse
position of the inter-pulse distortion table as a
relative distance from the start of the inter-pulse
distortion table, calculates a distortion every pulse
interval to obtain the absolute address of the
inter-pulse distortion table, and stores it in the first
reference address table. The second reference address
table creation unit regards the pulse position of the
inter-pulse distortion table as a relative distance from
the start of a multipulse search table, calculates a
distortion every pulse interval to obtain the absolute
address of the multipulse search table, and stores it in
the second reference address table. The search table
creation unit reads out absolute addresses from the
first and second reference address tables, and creates
the multipulse search table using them. A multipulse
search processing method is also disclosed.
Patent EP-1104951-A2 (EP)
Inventor: HARUTA KAZUMASA
IPC: H03B5/04
Filed: 2000-09-28
Abstract: The present invention provides a small-sized oscillator
facilitating the adjustment of a resonance frequency,
permitting mass productivity to be improved, sufficiently
suppressing the occurrence of a fundamental wave, and
permitting cost reduction, and provides radio equipment
using it. In this oscillator, an oscillation circuit is
formed by providing a line (7) and a Gunn diode (6) on a
dielectric substrate (3), a NRD guide as an output
transmission line is formed by disposing a dielectric strip
(5) between upper and lower conductor plates (1,2), and the
above-mentioned line (7) and the NRD guide are coupled. The
cut-off frequency of this NRD guide is determined so that
the fundamental wave component of an oscillation signal by
the oscillation circuit is cut off, and that higher harmonic
components are propagated.
Patent EP-1128435-A2 (EP)
Inventor: KWON YOUNG-SE
IPC: H01L23/522
Filed: 2000-11-02
Abstract: Disclosed is a microwave element which comprises a silicon substrate,
a porous silicon dioxide column formed on the silicon substrate, a silicon
column supported by the silicon substrate and having a height identical with
that of the porous silicon dioxide column, an active element formed on the
silicon column, and a passive element formed on the porous silicon dioxide
column and connected to the active element. According to the present invention,
elements that have very small signal loss in the microwave ranges over 1GHz
can be implemented by using the silicon substrate that has excellent thermal
conduction, flatness and is cheap compared to the aluminum substrate.
Patent EP-1109182-A2 (EP)
Inventor: OKADA KAZUHIRO
IPC: H03K17/975
Filed: 2000-12-12
Abstract: An intermediate displacement board (120)
composed of a metal plate is arranged on a printed
circuit board (110) having electrode patterns
(E1-E7) and then a strain generative body (130)
composed of silicon rubber is arranged on top thereof.
Then, the arrangement is fixed to the printed circuit
board (110) with attachments (140). Depressing a
displacement portion (133) causes a connecting
portion (132) to be deflected and an electrode (F0)
to be brought into contact with the electrodes (E1,
E2) to make them conductive, thereby allowing the
pushbutton switch to be turned ON. Depressing
further the displacement portion (133) causes an
elastic deformation portion (134) to be elastically
deformed and crushed and the intermediate
displacement board (120) to be pushed downward. The
capacitance of capacitors (C3-C7), which are
constituted by the electrodes (E3-E7) and the
intermediate displacement board (120), are varied
according to the depression of the intermediate
displacement board (120). By detecting the
variation in capacitance, it becomes possible to
detect three-dimensional components of an applied
force.
Patent EP-1136406-A2 (EP)
Inventor: MORAN DANIEL J
IPC: B65H16/10
Filed: 2000-12-20
Abstract: A side shuttle unwinder supports a pair of
parent rolls which are alternately rotated to unwind a
web. Each of the parent rolls is engageable with a
center drive mechanism for rotating the parent roll.
Each center drive mechanism can include core chucks
which are removably engageable with the parent roll.
The core chucks can be permanently or rotatably mounted
on the side shuttle.
Patent EP-1094050-A2 (EP)
Inventor: PAZZUCONI GIANNINO
IPC: C07C15/24
Filed: 2000-10-16
Abstract: A highly selective process is described for preparing 2,6-dimethylnaphthalene
which comprises reacting a naphthalene
hydrocarbon selected from naphthalene, methylnaphthalenes,
dimethylnaphthalenes, trimethylnaphthalenes, polymethylnaphthalenes,
and/or their mixtures with one or more benzene
hydrocarbons selected from benzene, toluene, xylenes,
trimethylbenzenes, tetramethylbenzenes, pentamethylbenzene
and/or hexamethylbenzene, under at least partially liquid
phase conditions and in the presence of a catalytic composition
comprising a zeolite belonging to the MTW structural
type and at least one element selected from P, B and Si.
The process is preferably carried out in the presence of a
methylating agent.
Patent EP-1020906-A2 (EP)
Inventor: ALERS GLENN B
IPC: H01L21/768
Filed: 2000-01-06
Abstract: The present invention relates to a conductive plug capacitor and
method of making for use in multi-level integrated circuit structures. In one
embodiment, a tungsten plug is formed in a window in a dielectric layer and thereafter
a cavity is formed in the plug. This cavity in the plug may serve as the lower electrode
for the capacitor, with a layer of dielectric deposited in the cavity and a top metal
electrode deposited on the dielectric layer. 
     An alternative embodiment makes use of not only the inner cavity
surfaces of the cavity in the tungsten plug, but also the outer sidewalls of the tungsten
plug. To this end, after formation of the tungsten plug heading the cavity formed
therein, a partial etchback of the dielectric layer in which the tungsten plug is formed is
effective. The capacitor dielectric is then deposited on the sidewalls, the top surface
and the interior of the cavity of the tungsten plug thereby increasing the area and
thereby the over capacitance.
Patent EP-1040808-A2 (EP)
Inventor: SUGA AYAMI
IPC: A61F13/26
Filed: 2000-03-30
Abstract: An applicator 1 for sanitary tampon includes an outer
cylindrical tube 2 formed with the maximum outer diameter
region 11. The outer cylindrical tube 2 has its outer
diameter gradually increasing rearwardly from its front end
until the maximum outer diameter region 11 is reached and
then gradually decreasing rearwardly. The maximum outer
diameter region 11 extends within 1/2 of a full length of the
outer tube 2 as measured from its front end.
Patent EP-1069435-A2 (EP)
Inventor: KATANO KAORU
IPC: B60G17/019
Filed: 2000-06-28
Abstract: A rolling bearing unit for supporting a wheel, comprising a stationary race
which has a stationary peripheral surface formed with a stationary raceway, being
not rotatable during use, and supported by a suspension, a rotatable race which has
a rotatable peripheral surface formed with a rotatable raceway, being rotatable with
the wheel fixed thereto, rolling elements which are rotatably provided between the
stationary raceway and rotatable raceway, a vibration sensor which is supported by
the stationary race, a sensor rotor swhich is upported by the rotatable race and has
circumferential characteristics changing alternately and a rotation speed sensor
which is supported by the stationary race and has a detection portion facing the
sensor rotor.
Patent EP-1076159-A2 (EP)
Title: Stator vane blank and method of forming the vane blank
Inventor: HONDA KEITH T
IPC: F01D25/24
Filed: 2000-08-09
Abstract: A forged vane blank 96 for forming a stator vane, has a greater draft angle α at the
outer surface than the draft angle β at the inner surface as a result of the forging
operation. The angle α may be about 9° and the angle β less than 3°, for example
about 1½°.
Patent EP-1116682-A2 (EP)
Inventor: SCHWULST KYLE E
IPC: B66C1/12
Filed: 2000-12-05
Abstract: A hoist assembly 10 for lifting an object 12 includes a
support fixture 14 having three elongated support rails or
members 16, 18, and 20, a movable lever assembly 24, which
is mounted upon a spanning member 22, and three
interconnecting chains, members or assemblies 26, 28, and
30 which are coupled to fixture 14 and to object 12.
Movable lever assembly 24 moves from a first position to a
second position when object 12 is lifted, thereby shifting
the center of gravity 142 of the fixture 14 and allowing
fixture 14 and object 12 to remain in a level or
horizontal position.
Patent EP-1111096-A2 (EP)
Inventor: MORRISSEY DENIS
IPC: C25D5/34
Filed: 2000-12-14
Abstract: Disclosed are methods of repairing metal seed layers prior to subsequent metallization. Such repair methods provide metal seed layers disposed on a substrate that are substantially free of metal oxide and substantially free of discontinuities.
Patent EP-1150681-A2 (EP)
Inventor: ASMUSSEN BODO
IPC: C07D487/04
Filed: 2000-02-08
Abstract: Desoxypeganin und seine pharmazeutisch annehmbaren Säureadditionssalze können zur Behandlung der Nikotinabhängigkeit verwendet werden. Diese Substanzen werden vorzugsweise in einer kontinuierlichen und kontrollierten Weise verabreicht. Die pharmazeutische Darreichungsform ermöglicht eine kontrollierte Freisetzung für z.B. orale, transdermale oder auf anderem Wege parenterale Verabreichung
Patent EP-1194560-A2 (EP)
Title: Antigenic neisserial peptides
Inventor: MASIGNANI VEGA
IPC: A61P31/04
Filed: 2000-05-19
Abstract: W099/24578 discloses a large number of proteins from Neisseria meningitidis and Neisseria gonhorroeae The present invention relates to fragments of the protein having the amino acid sequence set forth in SEQ ID NO:650 of W099/24578, which fragments comprise at least one antigenic determinant of said protein.
Patent EP-1192108-A2 (EP)
Inventor: LING TIEN-FEING
IPC: C02F5/08
Filed: 2000-06-13
Abstract: Methods for inhibiting scale deposits in an aqueous system. The method may include at least one of adding and forming anti-scalant in the aqueous system such that an amount of anti-scalant in the aqueous system is up to about 1000 ppm, wherein the anti-scalant comprises at least one or polyvalent metal silicate and polyvalent metal carbonate, wherein the aqueous system has a pH of at least about 9, and wherein a mean particle size of the anti-scalant is less than about 3 microns. The method includes at least one of adding and forming anti-scalant in the aqueous system, wherein the anti-scalant comprises at least one of polyvalent metal silicate and polyvalent metal carbonate, and adding copolymer of maleic anhydride and isobutylene. Compositions therefor.