baber/WOPTO huggingface dataset:
Patent CA-2414500-A1 (CA)
Title: Agonist-aversive combination medicines
Inventor: DOYLE CHRISTOPHER S
IPC: A61K31/485
Filed: 2002-12-17
Abstract: ABSTRACT       Alcohol disorders have been treated with a variety of therapies, including pharmaceutical. Benzodiazepines, are one type of pharmaceutical that has aided in treating the anxiety associated with alcohol disorders, however there are serious risks of abuse and dependence. Disulfiram is another pharmaceutical that provides a deterrent against consuming alcohol since it causes a person to become very ill when combined with alcohol. The deterrent effect of disulfiram is only effective when taken and non-compliance is a major limitation. This invention relates to a combination pharmaceutical medicine of disulfiram and a benzodiazepine that acts in an agonist-aversive manner for people with alcohol disorders. The combination of disultiram and a benzodiazepine acts to reduce anxiety and deter alcohol consumption at the same time. This invention also relates to other combinations of agonist and aversive medicines to reduce anxiety and deter alcohol consumption. This invention also relates to aversive medicines combined with other agents to treat medical conditions, which medical conditions or agents' effectiveness are negatively impacted by the consumption of ethanol.
Patent CA-2415558-A1 (CA)
Title: Sels d'addition acides de derives hydropyridiques
Inventor: INOUE TERUHIKO
IPC: A61P9/10
Filed: 2001-07-03
Abstract: La présente invention concerne des sels d'addition acides de 2-acétoxy-5-(.alpha.-cyclopropyl-carbonyl-2-fluorobenzyl)-4,5,6,7-tétrahydrothiéno[3,2-c]-pyridine. Ces sels d'addition acides se distinguent par leur aptitude à l'absorption par voie orale, par leur action d'activation du métabolisme et d'inhibition de l'agrégation plaquettaire, par leur faible toxicité, et par leur stabilité au stockage et à la manutention. Ces sels conviennent comme médicaments, de préférence comme médicaments prophylactiques ou thérapeutiques, et plus particulièrement comme médicaments thérapeutiques dans le cas d'affections provoquées par le thrombus ou l'infarcissement, mais avec une nette préférence comme médicaments prophylactiques ou thérapeutiques, et plus particulièrement comme médicaments thérapeutiques pour traiter la thrombose ou l'infarctus.
Patent CA-2415605-A1 (CA)
Inventor: BILODEAU THOMAS D
IPC: B66C23/90
Filed: 2003-01-06
Abstract: An apparatus for measuring an extended length of a multi-section telescopic boom. The apparatus includes a telescopic boom having at least three sections. One section is of a fixed length. The remaining, at least two sections, are telescopically extendable. A signal generator is mounted on one of the sections. A target is mounted on an adjacent one of the sections. The distance from the signal generator to the target is measured. A processor is provided which is adapted to receive data regarding the distance from the signal generator to the target and extrapolate the data using a known relationship between the telescopic sections to calculate the extended length of the telescopic boom.
Patent CA-2415978-A1 (CA)
Title: Releasable and retrievable vascular filter system
Inventor: RUSSELL SCOTT
IPC: A61B17/00
Filed: 2003-01-06
Abstract: A releasable and retrievable vascular filter system comprising a filter, a porous filter membrane attached to the filter, and an anti-migration feature for causing the filter to remain substantially stationary in the lumen of the vessel during the clinical procedure. The releasable and retrievable vascular filter system minimizes or substantially eliminates filter movement during the procedure, which may result in damage to the lumen, and/or the release of embolic particulates captured within the filter. The releasable and retrievable vascular filter system also allows for guidewire exchanges, which may be necessary for successful completion of the clinical procedure.
Patent CA-2416224-A1 (CA)
Inventor: JOHNSON SCOTT E
IPC: A61P31/04
Filed: 2001-07-10
Abstract: La présente invention concerne des peptides à antigènes multiples (MAP) qui confèrent une protection contre l'infection par S. pneumoniae. Ces peptides à antigènes multiples comprennent des peptides qui se lient de manière immunospécifique aux anticorps monoclonaux. La présente invention concerne également des vaccins renfermant ces mêmes peptides immunogènes ainsi que des procédés qui permettent de conférer une immunité de protection contre l'infection par Streptococcus pneumoniae au moyen de l'administration d'une composition thérapeutique comprenant les MAP selon l'invention.
Patent CA-2416423-A1 (CA)
Title: Auxiliary system for vehicle air conditioning, battery charging, and accessory operation
Inventor: PETRUNIA-BLACQUIERE JANET
IPC: B60H1/32
Filed: 2003-01-14
Abstract: An auxiliary engine generates electricity through an alternator, to charge the vehicle battery and selectively run an electric motor for air conditioning when the vehicle's primary engine is not operating. Operation of the electric motor produces rotation of the drive shaft of the vehicle's air conditioning compressor, the output shaft of the electric motor being connected via a centrifugal clutch, and a drive belt on a pulley integral to the clutch, to a pulley bolted directly to the drive shaft of the compressor. There is no use made of the vehicle's existing electromagnetic clutch at the compressor location, i.e. it remains disengaged when the auxiliary system is operating, and is engaged only when air conditioning is called for in normal vehicle operation, i.e. when the primary engine is running. The electricity generated by the auxiliary engine can also be used to operate other accessories, if desired, such as lighting, televisions, VCRs, refrigerators and other like accessories.
Patent CA-2417371-A1 (CA)
Title: Method for removing engine deposits in a gasoline internal combustion engine
Inventor: AHMADI MAJID R
IPC: F02M33/00
Filed: 2003-01-22
Abstract: Disclosed are methods for removing engine deposits in a gasoline internal combustion engine by introducing a cleaning composition into an air-intake manifold of a warmed-up and idling gasoline internal combustion engine and running the engine while the cleaning composition is being introduced. One such cleaning composition suitable for these methods comprises (a) a phenoxy mono- or poly(oxyalkylene) alcohol; (b) at least one solvent selected from (1) an alkoxy mono- or poly(oxyalkylene) alcohol and (2) an aliphatic or aromatic organic solvent; and (c) at least one nitrogen-containing detergent additive.
Patent CA-2417618-A1 (CA)
Inventor: HEGEMIER TIMOTHY A
IPC: F01L3/08
Filed: 2003-01-29
Abstract: A radially compliant valve stem seal assembly for an internal combustion engine includes a metallic retainer having a plurality of circumferentially spaced, axially depending legs. Each of the legs includes at least one radially inwardly depending protuberance adapted to engage a valve guide surface. The legs are arranged and disposed on the retainer to be radially flexible, yet axially stiff, to balance forces of installation against those of securement of valve stem seal assembly over a wide valve guide diameter tolerance range. W one disclosed embodiment, the retainer has three separate circumferentially spaced legs, each including a single dimple in its structure. The dimples are adapted to provide the only direct contact of the legs with the valve guide circumference: The retainer legs are adapted to flex radially outwardly, and produce a spring tension between the dimples and the guide for maintaining the dimples in engagement with the valve guide.
Patent CA-2420507-A1 (CA)
Title: Method for producing a solid herbicide formulation
Inventor: ZAGAR CYRILL
IPC: A01N43/42
Filed: 2001-08-30
Abstract: The invention relates to a method for producing a solid herbicide formulatio n containing a) a herbicide from the group of sulfonylurea, or the salts there of which are useful in the agricultural domain, b) optionally at least one othe r herbicide, c) optionally a safener, and d) at least one formulation adjuvant . A suspension is formed in water, consisting of the sulfonylurea a), optional ly at least one other herbicide b), optionally a safener c) and at least one formulation adjuvant d). The suspension is adjusted to a pH value between 6. 5 and 8 by adding an acid or a base, and is then dried to obtain the solid formulation.
Patent CA-2420655-A1 (CA)
Title: Large rectangular baler having hydraulically powered functions, and control system therefor
Inventor: DEMOREST DONALD WAYNE
IPC: A01F15/08
Filed: 2003-02-28
Abstract: A large rectangular baler includes pickup and packer rotors, a pivotable stuffer, a plunger head, a knotter shaft and a needle yoke, and tension panels that are all driven hydraulically and independently controlled through electrically controlled valves that actuate the various hydraulic power devices used to power the various functions. An electronic control unit is coupled to each of the control valves and receives feedback signals from the controlled functions which are compared with values representing desired function results so as to further control the valves to attain the desired results. In addition to the feedback signals from the powered functions, signals from a bale length sensor and a ground speed sensor are also coupled to the electronic control unit for use in controlling the powered functions.
Patent CA-2421936-A1 (CA)
Title: (2-azabicyclo[2.2.1]hept-7-yl)methanol derivatives as nicotinic acetylcholine receptor agonists
Inventor: SCHIEMANN KAI
IPC: C07D401/12
Filed: 2001-09-11
Abstract: The invention relates to substances of general formula (I), wherein X is selected from the following group: NH, NR4, O and S, R1 is selected from the  following group: hydrogen, linear and branched, substituted and unsubstitute d C1-C10-alkyl groups, substituted and unsubstituted C5-C10-aryl groups, substituted and unsubstituted C4-C10-heteroaryl groups, acyl groups, thioacy l groups, carbonyl carboxy groups, N-organyl-substituted carbamoyl groups and organosulfonyl groups, R2, R3, independently of each other, are chosen from the following group: C1-C10-alkyl groups, C5-C12-aryl groups and C4-C12- heteroaryl groups, these groups being unsubstituted or having one or more substitutents which are chosen independently of each other from the followin g group: halogens, alkoxy groups, aryloxy groups, nitro groups, C1-C5- alkoxycarbonyl groups, alkyl or acyl groups and cyano groups, optionally substituted with fluorine, and R4 is selected from the following group: hydrogen, linear and branched, substituted and unsubstituted C1-C10-alkyl groups, substituted and unsubstituted C5-C10-aryl groups, substituted and unsubstituted C4-C10-heteroaryl groups, acyl groups, thioacyl groups, carbon yl carboxy groups, N-organyl-substituted carbamoyl groups and organosulfonyl groups; or a physiologically compatible salt thereof.
Patent CA-2422537-A1 (CA)
Inventor: WILLSTUMPF ERICH
IPC: B65B39/12
Filed: 2003-03-18
Abstract: The invention relates to a needle holder (5) for use in a filling machine, the needle holder serving for accommodating a plurality of needles (6) for filling vials, ampoules or the like, and the respective needle having a tubular needle section (7) and a needle attachment (8) which can be connected to a filling tube or the like, and with means for fastening the needles on the needle holder.        It is an object of the invention to ensure, in the case of such a needle holder, that needles can be changed simply and within a short period of time under optimal sterility conditions. This is achieved by a retaining element (11) which is provided on one side with a plurality of mutually parallel grooves (13) for accommodating the needle sections of the needles, and also by clamping elements (16) which can be connected to the retaining element and are intended for fixing the needles in the grooves.
Patent CA-2422604-A1 (CA)
Inventor: FUJIWARA MASAHIRO
IPC: G01S13/88
Filed: 2001-09-10
Abstract: La présente invention concerne un testeur électromagnétique comprenant une antenne d'émission, une antenne de réception, une unité de traitement de signal de réception servant à produire un signal d'analyse en se basant sur un signal de détection issu de l'antenne de réception, et une unité de traitement d'analyse servant à réaliser un traitement d'analyse spécifié en se basant sur le signal d'analyse. Selon l'invention, l'unité de traitement d'analyse comprend un élément de calcul de constante diélectrique intra- milieu qui sert à subdiviser un signal d'analyse en une pluralité d'intervalles de temps, et à réaliser un calcul spécifié sur les cycles moyens du signal d'analyse dans des intervalles de temps respectifs, afin de calculer les constantes diélectriques moyennes du milieu à l'intérieur des intervalles d'épaisseur du milieu correspondant à des intervalles de temps respectives, ce qui permet, même à une personne non qualifiée, de réaliser facilement une mesure de la constante diélectrique pour chaque épaisseur du milieu et une épaisseur en dessous vers un objet de test.
Patent CA-2423285-A1 (CA)
Inventor: WAGNER ROLAND
IPC: C08G77/54
Filed: 2001-07-27
Abstract: The invention provides a polysiloxane compound comprising:   a) at least one polyalkylene oxide structural unit with the general formula:   -A-E-, -E-A'-, -A-E-A'- and/or -A'-E-A-wherein A = -CH2C(O)O-, -CH2CH2C(O)O-, -CH2CH2CH2C(O)O-, -OC(O)CH2-, -OC(O)CH2CH2- and/or -OC(O)CH2CH2CH2-A' = -CH2C(O)-, -CH2CH2C(O)-, CH2CH2CH2C(O)-, -C(O)CH2-, -C(O)CH2CH2- and/or -C(O)CH2CH2CH2-E = a polyalkylene oxide group of the general formulae:   -[CH2CH2O]q-[CH2CH(CH3)O]r- and/or -[OCH(CH3)CH2]r-[OCH2CH2]q-with q = 1 to 200, r = 0 to 200, whereby the terminal position oxygen atom of Group A binds to the terminal position -CH2-group of Group E, and the terminal position carbonyl carbon atom of Group A' binds to the terminal position oxygen atom of Group E  forming ester groups in each case, and/or at least one terminal position polyalkylene oxide structural unit of the formula wherein A and E have the aforementioned meaning, and R2 = is H, straight chain, cyclical or branched C1-C20-hydrocarbon radical, which is optionally interrupted by -O-, or -C(O)- and is optionally substituted with -OH, and is optionally acetylenic, olefinic or aromatic b) at least one bivalent or trivalent organic radical which contains at least one ammonium group, c) at least one polysiloxane structural unit with the general formula:   -K-S-K-, with S= (see formula I) wherein R1 = C1-C22-alkyl, C1-C22-fluoralkyl or aryl, n = 0 to 100, and the (see formula II) groups are identical or different if several S Groups are present in the polysiloxane compound, K = a bivalent or trivalent straight chain, cyclical or branched C2-C40 hydrocarbon radical which is optionally interrupted by -O-, -NH-, (see formula III), -NR1-, -C(O)-, -C(S)-, (see formula IV) or (see formula V) and is optionally substituted with -OH, wherein R1 is defined as above, or represents a bond to a bivalent radical R3 wherein R3 is bivalent R3 represents a monovalent or bivalent straight chain, cyclical or branched C1-C20 hydrocarbon radical which is optionally interrupted by -O-, -NH-, -C(O)-, or -C(S)-and is optionally substituted with -OH, or -A-E-R2, wherein A, E and R2 are defined as above, wherein the K radicals are identical or different from each other, and when K represents a trivalent radical, the saturation of the third valence takes place through a bonding to the above mentioned organic radical which contains at least one ammonium group, and d) at least one organic or inorganic acid radical for neutralization of the charges resulting from the ammonium group(s). The polysiloxane compound of the invention may be useful in cosmetic formulations for skin or hair care; in a polish for treatment of a hard surface, especially for drying after machine washing and in fabric treatment.
Patent CA-2423875-A1 (CA)
Inventor: YAMAMOTO TAKAYUKI
IPC: B60T8/50
Filed: 2001-09-28
Abstract: A vehicular brake control apparatus comprises: an electric motor that presses the braking member against the braked member to apply a braking torque to the wheel, operational state detecting means for detecting an operational state of the vehicle braking torque change request determining means for determining selectively determines that the braking torque is to be increased and that the braking torque is to be reduced, based on the quantity of state; and current controlling means for controlling the supply of electrical current to the electric motor so that the electric motor is caused to rotate in a predetermined direction if it is determined that the braking torque is to be increased, and so to decrease the electrical current supplied to the electric motor if it is determined that the braking torque is to be reduced.
Patent CA-2426690-A1 (CA)
Title: Non-metallic implant devices and intra-operative methods for assembly and fixation
Inventor: ESTES BRADLEY T
IPC: A61B17/58
Filed: 2001-10-23
Abstract: This invention relates to orthopedic implants (10, 50, 90, 100, 140, 190, 250, 280, 300, 320, 340, 360, 370, 380, 400 and 440) and to methods of treating bone defects. More specifically, but not exclusively, the present invention is directed to non-metallic implants and to methods for intra-operative assembly and fixation of orthopedic implants to facilitate medical treatment. The non-metallic implant assembly can be secured to underlying tissue by a fastener, such as a bone screw, that is capable of swelling on contact with fluid in the underlying tissue. Alternatively, the non-metallic implant assembly can be assembled intra-operatively using a fastener that is adhesively bonded to a bone plate or the bone plate can be deformed using heat, force or solvents to inhibit withdrawal of the fastener. In preferred embodiments, both the fastener and the bone plate are formed of biodegradable material.
Patent CA-2427047-A1 (CA)
Title: Mineralized collagen-polysaccharide matrix for bone and cartilage repair
Inventor: LIU LIN SHU
IPC: A61K38/18
Filed: 2001-10-05
Abstract: A matrix and a method for preparing it are provided to support the growth of tissue, such as bone, cartilage or soft connective tissue. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted to form covalent linkages to mineralized collagen. The matrix can be implanted or injected, or the polyaldehyde polysaccharide and mineralized collagen starting minerals can be separately injected to form the matrix in situ.
Patent CA-2431201-A1 (CA)
Inventor: ZHANG AIGUO
IPC: G01N30/88
Filed: 2001-12-13
Abstract: The present invention provides standard diluents for use in multiplex assays comprising a biological fluid that normally includes two or more different target analytes but that is substantially free of the two or more different target analytes, as well as kits and methods relating to the standard diluent. The standard diluents of the invention provide an accurate and reliable means to calibrate the amount of multiple target analytes in a single assay.
Patent CA-2432942-A1 (CA)
Title: Carbohydrate deficient transferrin (cdt)-specific antibodies, their preparation and use
Inventor: ALTHAUS HARALD
IPC: G01N33/53
Filed: 2003-07-04
Abstract: The present invention relates to antibodies which, in aqueous solution, selectively bind to a transferrin-homologous carbohydrate deficient transferrin (CDT) without the latter needing to be bound to a- solid phase. CDT is characterized by at least one of the two oligosaccharide chains which are normally bound to Asn 413 and/or Asn 611 of transferrin being entirely or substantially entirely lacking.
Patent CA-2433656-A1 (CA)
Title: Hormone replacement therapy method and its administration form
Inventor: KULMANN HERMANN
IPC: A61K31/567
Filed: 2002-01-08
Abstract: Method for hormone replacement therapy, in which at least in the established  postmenopause a daily unit with at least one hormonal component, namely with  at least estrogen (E) and/or at least one gestagen (G) is administered permanently and continuously every day, characterized in that in at least on e ingestion period preceding the permanent administration of hormone daily uni ts is provided an ingestion pause (P), in which either no daily units or placeb os or daily units with a much lower estrogen and/or gestagen content than durin g the permanent administration of hormone daily units in the established postmenopause and during the ingestion phase(s) of the preceding ingestion period are administered, as well as administration form for hormone therapy.
Patent CA-2434711-A1 (CA)
Inventor: LIU ANGUS
IPC: A47G21/14
Filed: 2003-07-09
Abstract: The present invention relates to a storage carriage for storing a plurality of knives and other bladed implements. The storage carriage allows insertion of bladed implements irrespective of their ordering within the carriage, and protects the user from contact with the blades of the stored implements. In addition, the storage carriage can be mounted to either a horizontal or a vertical surface. The storage carriage comprises an implement handle supporting panel presenting at least one elongated slot defined by a front and rear inside wall for receiving bladed implements, wherein said elongated slot is sized to retain a plurality of bladed implements by their handles, a blade shield extending perpendicular from the implement handle supporting panel and an attachment means for attaching the storage carriage to a support surface.
Patent CA-2439392-A1 (CA)
Inventor: SANDBAKKEN PER OLAV
IPC: C09J161/30
Filed: 2002-02-25
Abstract: A process for gluing laminated products with a curing amino adhesive, such a s melamine urea formaldehyde (MUF) adhesive or urea formaldehyde (UF) adhesive , wherein a hardener comprising acid, acid salt and/or acid generating salt an d a polymer dispersion or a mixture of different polymer dispersions and conventional additives, and the adhesive are applied separately at the parts to be glued, that the parts thereafter are joined and that the glue thereaft er is cured under pressure, is described. Additionally, a use of a polymer dispersion or a mixture of different polymer dispersions in a hardener for u se in a method for separate application of adhesive and hardener is disclosed.< /SDOAB>
Patent CA-2442544-A1 (CA)
Inventor: BUSSEUIL DOMINIQUE
IPC: B62D29/00
Filed: 2002-05-07
Abstract: A structural reinforcement for a hollow member comprising a rigid reinforcing member having a shape that substantially conforms to the cross section of the hollow member to be reinforced with an expandable adhesive material over at least a portion of the surface of the structural reinforcement having pairs of extensions on its external surface which control and direct the direction in which the adhesive material expands to bond the reinforcing member to the internal surface of the hollow member, some of the extensions also provide improved reinforcement.
Patent CA-2443935-A1 (CA)
Inventor: CAI TIAN-QUAN
IPC: A61K38/17
Filed: 2002-04-12
Abstract: The invention encompasses a method for treating or preventing an inflammator y disease or condition in a mammalian patient in need of such treatment or prevention comprising administering to said patient a compound that is capab le of simultaneously binding PPAR.alpha. and PPAR.gamma. or concomitantly administering a compound that selectively binds PPAR.alpha. with a compound that selectively binds PPAR.gamma. in an amount that is effective to treat o r prevent the inflammatory disease or condition. The invention also encompasse s a method for treating or preventing an inflammatory disease or condition in a mammalian patient in need of such treatment or prevention comprising administering to said patient a compound that is capable of simultaneously binding and activating PPAR.alpha. and PPAR.gamma. or concomitantly administering a compound that selectively binds and activates PPAR.alpha. wi th a compound that selectively binds and activates PPAR.gamma. in an amount tha t is effective to treat or prevent the inflammatory disease or condition.</SDO AB>