Patent SG-11201810428P-A (SG)
Title: Composition and methods for microbiota therapy
Inventor: BARAM DAVID
IPC: A61K35/74
Filed: 2017-05-25
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111H11111111111111111110101111111111010111110111111111111101111111011110111111 Organization 0 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\"1 WO 2017/203533 Al 30 November 2017 (30.11.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 35/66 (2015.01) A61K 35/744 (2015.01) kind of national protection available): AE, AG, AL, AM, A61K 35/74 (2015.01) A61K 35/745 (2015.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, A61K 35/741 (2015.01) A61K 31/00 (2006.01) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (21) International Application Number: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, PCT/IL2017/050587 HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (22) International Filing Date: MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 25 May 2017 (25.05.2017) PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (25) Filing Language: English SD, TT, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 62/341,205 25 May 2016 (25.05.2016) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (71) Applicant: MYBIOTICS PHARMA LTD. [IL/IL]; 2 Ilan TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Ramon, 2nd floor, P.O box 4061, 7414001 Ness Ziona (IL). EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (72) Inventors: BARAM, David; 3 Dekel Street, 7290500 Nir- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Zvi (IL). DABUSH, David; 7A Hama'ayan Street, P.O.B TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, _ 182, 7684100 Mishmar David (IL). DIAMANT, Rachel; 2 KM, ML, MR, NE, SN, TD, TG). Hama'ayan Street, P.O.B 566, 4069600 Ein-Vered (IL). — = (74) Agent: KESTEN, Dov et al.; 55 Yigal Alon St, 6789115 Tel Aviv (IL). = = Title: COMPOSITION AND METHODS FOR MICROBIOTA THERAPY = (54) (57) : The present invention provides a composition = 200 comprising a co-culture of at least two distinct bacterial families, differing growth and/or proliferative conditions. In some = having I embodiments, the composition comprises a plurality of bacterial = 220 genera with high similarity to microbial flora. = = I = 11 Filter the sunpensinn J 240 = I = 260 = I = = - 280 ., - = I ' ' - 100 medium and prolifecntice conditions 1 - 1 I Remove medium 1 320 [ en en kr) I M 0 ei ., . ----- bormulue fn - dminieaation Re-smtt breeze or lyophilize 60 IN - 11 FIGURE 1 © ei O [Continued on next page] WO 2017/203533 Al MIDEDIMOMMIDIRMEM001010111410110MMOVOIMIE Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of