baber/WOPTO huggingface dataset:
Patent EA-018193-B1 (EA)
Title: Compounds and pharmaceutical compositions for modulation of uric acid levels
Inventor: QUART BARRY D
IPC: C07D235/28
Filed: 2008-11-26
Abstract: Described herein are compounds of general formula (I) useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.
Patent EA-018632-B1 (EA)
Title: Neurosteroid compounds
Inventor: GRAVANIS ACHILLEAS
IPC: A61K31/58
Filed: 2008-06-17
Abstract: The present invention relates to novel neurosteroid derivatives with anti-apoptotic, neuroprotective and neurogenic properties that act on the nervous system as well as methods for making the same and their applications in the treatment and/or prevention or amelioration of neurodegenerative diseases related to neuronal apoptosis or neuronal injury, or conditions related to or resulting from apoptosis, including but not limited to Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and amyotrophic lateral sclerosis (ALS), retinal degeneration and detachment, peripheral neuropathy caused by genetic abnormalities, diabetes, polio, herpes, AIDS and chemotherapy, brain trauma, or ischemia and stroke. The active compounds are represented by Formula (I)wherein R, R, R, R, R, R, R, A, B, X, Y and Z are defined in the description of the invention. The present invention also includes compositions which comprise one or more of the compounds of Formula (I).
Patent EA-020782-B1 (EA)
Title: Coupling head for a track-guided vehicle
Inventor: SCHULZ JOERN
IPC: B61G3/00
Filed: 2011-03-10
Abstract: The invention relates to coupling head (1) for a track-guided vehicle for forming a mechanical connection to a counter-coupling head (1') coupling head (1) comprising a coupling funnel (2) for accommodating a connected or connectable with the mating coupling head (1') of the force-transmitting coupling element (14), and at least one movable locking element (3a, 3b), adopted to move relative to the coupling funnel (2) perpendicular to the coupling direction (L), the coupling element accommodated with in the coupling funnel (2) in a releasable engageable manner for preventing slipping-off of in the coupling funnel (2), wherein for making disconnection easier a lever member (4a, 4b) is further provided in the coupling head (1) of such type and hinged connected to said at least one locking element (3a, 3b) and adapted to turn in a vertical plane and move relative to the coupling funnel (2) perpendicular to the coupling direction (L) through the actuating element (5), characterised in that it comprises two locking elements (3a, 3b) positioned opposite each other relative to the longitudinal axis of the coupling hopper (2), each is adapted to move relative to the coupling hopper (2), perpendicular to the coupling hopper (2), and pivotally connected to corresponding members (4a, 4b), wherein the lever members (4a, 4b) are adapted to simultaneous movement relative to the coupling funnel (2) perpendicular to the coupling direction (L) through the common actuating element (5), further comprising a power transmission mechanism provided for transmitting upon actuation of the actuating element (5) produced linear force on the lever elements (4a, 4b) of the locking elements (3a, 3b). Said power transmission mechanism comprises an eccentric disc (7) adapted to rotate around an axis extending perpendicular to the coupling direction (L) and perpendicular to the movement direction of the locking element (3a, 3b) runs, and a side surface (8) of the eccentric disc (7) is non-symmetrical relative its pivot point (P), the lever elements (4a, 4b) of the locking elements (3a, 3b) on the one hand and the actuating element (5) on the other hand adjoin the non-symmetrical side surface (8), wherein a torque is generated upon actuation of the actuating element (5) on the eccentric disc (7), which at least partially acts as linear force on the lever elements (4a, 4b) of the locking elements (3a, 3b) perpendicular to the coupling direction (L).
Patent EA-019512-B1 (EA)
Title: Il6 mediated immunotherapeutics
Inventor: MISHER LYNDA
IPC: A61K39/395
Filed: 2009-07-02
Abstract: A binding domain polypeptide and fusion proteins thereof that recognize an IL6/IL6 receptor complex, as well as compositions and methods of use thereof.
Patent EA-019393-B1 (EA)
Title: Reinforcement comprising two reinforcing materials and tyre comprising such a reinforcement
Inventor: DETULLIO MURIELLE
IPC: B60C15/06
Filed: 2010-05-04
Abstract: Tyre reinforcement (10) having a two-materials reinforcing structure consisting of at least one plurality of extensible first reinforcing elements (1) and at least one plurality of non-extensible second reinforcing elements (2), these first and second reinforcing elements being mutually parallel and distributed in alternation in appropriate proportions so as to achieve the desired level of reinforcement, these first and second reinforcing elements being situated in one and the same mean surface, this reinforcement being such that the extensible first reinforcing elements (1) are coupled to the non-extensible second reinforcing elements (2) over a coupling length Lc which is shorter than the length L1 of the extensible first reinforcing elements (1) so that, with each of the first and second reinforcing elements having two ends, at least of the ends of the extensible first reinforcing elements (1) is offset in relation to the two ends of the non-extensible second reinforcing elements (2).
Patent EA-022061-B1 (EA)
Title: Smac mimetic
Inventor: CONDON STEPHEN M
IPC: C07D217/00
Filed: 2010-06-25
Abstract: The present invention relates to a compound of formulaor a pharmaceutically acceptable salt thereof. The invention also relates to a pharmaceutical composition for the treatment of a proliferative disorder, comprising the compound according to the present invention.
Patent EA-020499-B1 (EA)
Title: Continuous transesterification method
Inventor: KRULL MATTHIAS
IPC: C11C3/00
Filed: 2010-09-03
Abstract: The invention relates to a continuous method for producing esters, in which at least one polyol ester of formula (I) (R-COO)R, where Rrepresents hydrogen or an optionally substituted hydrocarbon group containing 1 to 50 carbon atoms, Rrepresents an optionally substituted hydrocarbon group containing 2 to 10 carbon atoms, and m represents a number from 2 to 10 and is smaller than or equal to the number of carbon atoms in R, is reacted with at least one monohydric alcohol of formula (II) R-OH, where Rrepresents an optionally substituted hydrocarbon group containing 1 to 30 C atoms, using microwave radiation in a reaction tube, the longitudinal axis of which extends in the direction of propagation of the microwaves of a single-mode microwave applicator, so as to obtain at least one ester of formula (III) R-COO-R, where Rand Rhave the meanings indicated above.
Patent EA-024981-B1 (EA)
Title: Nebulizer
Inventor: BACH ALEXANDER
IPC: A61M15/00
Filed: 2010-11-22
Abstract: A nebulizer (1), in particular inhaler, having a pre-installed container is proposed. The container (3) has a fluid outlet (24) with two associated closures (25, 26). A second closure (26) is already pierced in a delivery state where the container (3) is pre-installed in the partly closed nebulizer (1). The first closure (25) is opened just before or when completely closing the nebulizer (1) and using the nebulizer (1).
Patent EA-024801-B1 (EA)
Title: Selective sphingosine 1 phosphate receptor modulators
Inventor: MARTINBOROUGH ESTHER
IPC: A61K31/425
Filed: 2010-11-15
Abstract: Described are compounds having the structure of Formula I-R or I-Sor a pharmaceutically acceptable salt thereof, wherein X is NH, NHC(=O)CHor NHCHCOOH, and Y is CN. Said compositions are the sphingosine 1 phosphate receptor agonist, including a compound of any one of claims 1-4, in combination with a pharmaceutically acceptable carrier or solvent. Also described is a method of treatment of inflammatory bowel disease (IBD) including ulcerative colitis and Crohn's disease in a patient, comprising administering an effective amount of the compounds of structural Formula I-R or I-S or a pharmaceutically acceptable salt thereof to the patient at a frequency and for a duration of time sufficient to provide a beneficial effect to the patient.
Patent EA-026016-B1 (EA)
Title: Method and apparatus for providing image data
Inventor: RODENBURG JOHN MARIUS
IPC: G01N21/47
Filed: 2011-09-22
Abstract: A method of providing image data for constructing an image of a region of a three dimensional target object, comprising providing, from a radiation source, incident radiation directed at a target object, detecting an intensity of radiation scattered by the target object, and determining image data for each of a respective plurality of slices within the target object each indicating one or more characteristics of the target object at a respective depth within the target object, wherein the image data is determined based on the detected intensity of radiation via an iterative process, wherein running estimates of the image data for each of the plurality of slices are updated step by step.
Patent EA-025828-B1 (EA)
Title: Fgfr1 extracellular domain combination therapies
Inventor: LONG LI
IPC: C07K19/00
Filed: 2011-11-14
Abstract: Methods of treating cancer comprising administering a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) and/or an FGFR1 ECD fusion molecule in combination with at least one additional therapeutic agent selected from docetaxel, paclitaxel, vincristine, carboplatin, cisplatin, oxaliplatin, doxorubicin, 5-fluorouracil (5-FU), leucovorin, pemetrexed, and bevacizumab are provided. Dosage packs comprising an FGFR1 ECD and/or an FGFR1 ECD fusion molecule and/or at least one additional therapeutic agent selected from docetaxel, paclitaxel, vincristine, carboplatin, cisplatin, oxaliplatin, doxorubicin, 5-fluorouracil (5-FU), leucovorin, pemetrexed, and bevacizumab are also provided. In some embodiments, a dosage pack comprises instructions for administering FGFR1 ECD and/or FGFR1 ECD fusion molecule with at least one additional therapeutic agent.
Patent EA-036660-B1 (EA)
Title: Sp35 ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF AND USE THEREOF IN TREATING DISORDERS OF THE CENTRAL NERVOUS SYSTEM
Inventor: MI SHA
IPC: A61K39/00
Filed: 2008-01-09
Abstract: The present invention provides antibodies specifically binding to human Sp35 polypeptide or antigen-binding fragments of said antibodies and the use thereof in treating CNS disorders, in particular, stroke, optic neuritis, CNS injury, spinal cord injury, disease or disorder associated with demyelination or dysmyelination, multiple sclerosis or acute ischemic optic neuropathy. Also provided are a polynucleotide and a vector encoding the claimed antibodies and fragments, and an isolated host cell for producing said antibodies and fragments, and a method of producing said antibodies and fragments.
Patent EA-025410-B1 (EA)
Title: Gelled food concentrate comprising pectin gel
Inventor: POPP ALOIS KONRAD
IPC: A23L29/231
Filed: 2013-06-26
Abstract: The present invention relates to a gelled food concentrate, in particular a gelled food concentrate to prepare a ready-to-eat end product like a soup, a sauce, or a gravy. It is an object to provide a gelled food concentrate, which upon dilution in an aqueous liquid provides a viscous ready-to-eat end product, most desirably agelled food concentrate with a homogenous texture and ingredient distribution. Surprisingly, these complications were overcome by a gelled food concentrate comprising water, a salt-sensitive gum, salt and a gelling pectin.
Patent EA-029811-B1 (EA)
Title: Air freshener
Inventor: FERNANDEZ TORRES DAVID
IPC: A61L9/12
Filed: 2013-01-24
Abstract: The application describes an air freshener comprising a container (1) which contains a perfuming liquid (2); a wooden cap (3) screwed onto the neck (1') of the container (1); and a diffusing string or wick (7) for diffusing the perfuming liquid (2). The wooden cap (3) is provided with an axial central duct (4) of small diameter which communicates with a second transverse duct (5) provided in an upper cylindrical extension (6) of the wooden cap (3), wherein the diffusing string or wick (7) is guided through the transverse duct (5) coming out from the wooden cap (3) being performed such that when the container (1) is turned upside down the perfuming liquid (2) can reach the diffusing string or wick (7) by flowing through the axial duct (4) and through the transverse duct (5) and can impregnate the diffusing string or wick (7) therein, and the wooden cap (3) is completely screwed onto the neck (1') of the container (1) until the upper edge (9) of the neck (1') abuts against the base (10) of the wooden cap (3).
Patent EA-034051-B1 (EA)
Title: Food supplement
Inventor: VACKAR PETR
IPC: A23L33/16
Filed: 2013-12-20
Abstract: The invention relates to food supplements having therapeutic activity. The supplement comprises active substances in the amount of 1 to 75% of curcumin, 1 to 25% of organic germanium compound and complementary substances. The technical result consists in reducing the neurotoxicity of aluminium and inflammatory reactions.
Patent EA-029688-B1 (EA)
Title: Ore production system
Inventor: MACINTYRE DANIEL
IPC: E21F13/00
Filed: 2014-05-20
Abstract: The present invention refers to a set of methods and procedures that may be combined in order to greatly increase the speed of development of an access ramp in a underground hard-rock mine. More particularly, the present invention was designed to target all the bottle-necks comprised by the access operation of a hard-rock mine that employs a Rail-Veyor machine. The invention also comprises an ore production line which consists in the sequential arrangement of a series of mining equipment between the work face and the entrance of a hard-rock mine. The invention also comprises a Hard Rock Mining Access Plan for a hard-rock mine which encompasses two parallel ramps interconnected by cross-cut passageways. Further, invention also comprises a Ground Support Installation method configured to shorten the time required for the installation of ground support inside of a hard-rock mine.
Patent EA-034896-B1 (EA)
Title: Replacement heart valve
Inventor: BEITH JASON G
IPC: A61F2/24
Filed: 2015-01-30
Abstract: A prosthetic valve has a support structure that meets with a plurality of leaflets capable of transitioning between open and closed states. The support structure can include a base frame with a polymer coating and the leaflets can be artificial. The interface between the support structure and each leaflet can be at least partially convex when viewed from an exterior of the support structure along a normal to a plane formed by a central axis of the support structure and a central axis of the leaflet.
Patent EA-039830-B1 (EA)
Title: Device to sow seeds of agricultural crops
Inventor: SESYAKIN VLADIMIR ILYICH
IPC: A01C7/20
Filed: 2017-12-27
Abstract: The objectives of the invention are to reduce the traction resistance of the sowing module and the cost of its maintenance, improve the quality and reduce energy costs for cutting plant residues while maintaining the ability of the device to create optimal conditions for seed germination capacity when sowing with traditional and minimum tillage, as well as upon a direct sowing. The device consists of a parallelogram suspension and a ripper disk knife installed on it, a hoe coulter with a frontal surface in the form of a two-sided wedge and a seed tube, and a depth controller. The knife is fixed with the possibility of movement on a vertical movable post of the parallelogram suspension, and the coulter is placed behind the knife and connected to it by means of a traverse. The role of the depth controller is taken on by an arched skid with an overlay, which has a narrowing in the area of action of the coulter point and grooves longitudinal to the sowing direction in the overlay, another option is counter-knives or rollers in the form of a truncated cone with a V-shaped installation frontally and tangentially to the knife, while projections of the rollers axis and the knife axis onto the soil coincide.
Patent EA-033511-B1 (EA)
Title: Plant for recycling of white slag generated during a steel production step
Inventor: BUIZZA DARIO
IPC: C22B7/04
Filed: 2016-01-21
Abstract: A plant for recycling of white slag which is generated during a steel production step, comprising a rotating cylinder internally of which the white slag is housed in a controlled atmosphere; the rotating cylinder comprising a first portion in which a controlled cooling is carried out so as to lead to a withering process of the white slag, with a consequent detachment of fragments and powders, and a second portion located in cascade from the first portion, in which the selection and the separation takes place of the fragments and powders of the white slag having a smaller grain size than a predetermined grain size; first means associated to the second portion of the rotating cylinder for extraction of the fragments and powders of the white slag having a grain size that is on average smaller than a predetermined size; second means, located in cascade to the second portion of the rotating cylinder for extraction of the fragments and powders of the white slag having a grain size that is on average higher than a predetermined size; a space afforded in the mantle of the first portion of the rotating cylinder; a cooling fluid contained internally of the space for enabling an indirect cooling of the white slag contained internally of the first portion of the rotating cylinder; means for feeding the cooling fluid into the space in a closed circuit; the plant being characterized in that it comprises storage means of the white slag; feeding means of the white slag from the storage means to the first portion of the rotating cylinder; wherein the first means and the second means enable extraction of the fragments and powders of the white slag in a continuous cycle with the rotation of the rotating cylinder, and in that the storage means of the white slag comprise a hopper peripherally provided with a space containing a cooling fluid so as to enable a first cooling of the white slag prior to inlet thereof into the first portion of the rotating cylinder; an overflow positioned superiorly of the hopper, frontally of the feeding zone of the white slag, provided for separating the white slag from any liquid metal still possibly present; the overflow having, on a side thereof facing the hopper, a containing head which enables retaining the liquid metal in the overflow and facilitating passage of the white slag which floats on the liquid metal due to the specific weight difference there-between, towards the underlying hopper.
Patent EA-037833-B1 (EA)
Title: Absorbent article
Inventor: SAITO KYOTA
IPC: A61F13/56
Filed: 2016-10-18
Abstract: There is provided an absorbent article including a front waist portion, a back waist portion and a crotch portion. The front waist portion (30) and the back waist portion (20) each include elastic regions X and Y extending along the lateral direction. A one-side end portion of the back waist portion (20) on a one side in the lateral direction is joined by a first joining portion (1b) to a one-side end portion of the front waist portion (30) on the one side in the lateral direction. An other-side end portion (200) of the back waist portion (20) on an other side in the lateral direction is joined by a second joining portion (2b) to a fastening member (40), and the fastening member (40) has a fastening portion (41) being capable of being fastened to the front waist portion (30) when putting on the absorbent article. While the front waist portion (30) and the back waist portion (20) being stretched in the lateral direction, the lateral distance (L6) of the front waist portion (30) from the lateral center (AC) of the absorbent main body (10) to a lateral end (30er) of the front waist portion (30) on the other side is smaller than the lateral distance (L8) of the back waist portion (20) from the lateral center (AC) of absorbent main body (10) to a lateral end (20er) of the back waist portion (20) on the other side.
Patent EA-034732-B1 (EA)
Title: Proportional metering pump, method for assembling and disassembling such a pump
Inventor: LAATIAOUI NAJIB
IPC: F04B53/22
Filed: 2017-04-06
Abstract: The invention relates to a proportional metering pump comprising a hydraulic machine (4) and a metering mechanism (7) provided with a nozzle (75), characterized in that it further comprises means for attaching the nozzle to the pipe for access to the cavity inside the hydraulic machine (43), said means comprising a securing ring (2) mounted in rotation about one of the ends of the nozzle (75), a locking ring (1) that is mounted so as to be able to translate along the longitudinal axis (9) around the pipe for access to the mixing chamber and is pressed, in the direction of the metering mechanism, against a shoulder created on said access pipe by means of a spring (3), the securing ring and the pipe being able to engage following a screw connection at the end of which they are secured in rotation so as to prevent unscrewing of the securing ring. The invention also relates to a method for assembling and disassembling a metering mechanism on a hydraulic machine of such a pump.
Patent EA-037208-B1 (EA)
Title: SUBSTITUTED PYRAZOLO[1,5-a]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS
Inventor: ANDREWS STEVEN W
IPC: C07D471/04
Filed: 2017-10-10
Abstract: Provided herein are compounds of the Formula Ior a pharmaceutically acceptable salt thereof, wherein A, B, X1, X2, X3, X4, ring D, E, Ra, Rb, n and m have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
Patent ES-2186532-B1 (ES)
Title: Sistema para disputar partidas y competiciones entre maquinas de juego electronicas, tales como para el juego de dardos, situadas en un mismo local o en ubicaciones remotas.
Inventor: QUETGLAS ARINO MIGUEL ANGEL
IPC: A63F13/79
Filed: 2001-04-04
Granted: 2004-07-16
Abstract: Sistema para disputar partidas y competiciones entre máquinas de juego electrónicas, tales como para el juego de dardos, situadas en un mismo local o en ubicaciones remotas que consiste en proporcionar los medios que comunican dichas máquinas entre sí formando una red, si están en un mismo local, o con otras máquinas situadas en ubicaciones remotas por medio de una red telemática mundial tal como internet, estableciendo las reglas que rigen el funcionamiento del conjunto del sistema y su interacción con un servidor de juegos situado en la red.