baber/WOPTO huggingface dataset:
Patent CA-2990161-A1 (CA)
Title: Traitement de c9ftd/als par ciblage de sequences de repetition etendues d'arn
Inventor: DISNEY MATTHEW D
IPC: C08G59/40
Filed: 2015-08-13
Abstract: Une étendue de répétition de C90RF72 provoque une démence frontotemporale et une sclérose latérale amyotrophique (c9FTD/ALS). L'ARN de la répétition étendue (r(GGGGCC)exp) forme des foyers nucléaires ou subit une traduction non ATG associée à une répétition (RAN) produisant des « protéines c9RAN ». Etant donné que la neutralisation de r(GGGGCC)exp pourrait inhiber ces événements potentiellement toxiques, on a pensé identifier des liants de petites molécules de r(GGGGCC)exp, un sondage chimique et enzymatique de r(GGGGCC)8 indique l'adoption par ce dernier d'une structure en épingle à cheveux en équilibre avec une structure quadruplex. Au moyen de ce modèle, on a conçu de petites molécules bioactives de ciblage de r(GGGGCC)exp et constaté qu'elles ont inhibé de manière importante la traduction RAN et la formation de foyers dans des cellules de culture exprimant r(GGGGCC)66 et dans des neurones trans-différenciés par rapport à des fibroblastes de véhicules d'étendue de répétition. Enfin, on a démontré que les protéines poly(GP) c9RAN sont spécifiquement détectées dans le fluide céphalo-rachidien de patient c9ALS. Nos découvertes ont mis en évidence de petites molécules de liaison avec r(GGGGCC)exp en tant que thérapie possible contre la C9FTD/ALS, et suggéré que les protéines c9RAN pourraient potentiellement servir de biomarqueurs pharmacodynamiques pour évaluer l'efficacité de thérapies qui ciblent r(GGGGCC)exp.
Patent CA-2990396-A1 (CA)
Inventor: FECHTER CARY ERWIN
IPC: A61P25/00
Filed: 2016-06-20
Abstract: A pharmaceutical composition containing a benzhydrylsulfinylacetamide antidepressant, and either or both of an SSRI uptake inhibitor and/or a stimulating antidepressant has been shown to be effective in ameliorating symptoms of dementia, including those forms of dementia diagnosed as Alzheimer's disease.
Patent CA-2991263-A1 (CA)
Inventor: COHEN NATHAN
IPC: H01Q1/24
Filed: 2016-07-27
Abstract: Antennas, antenna systems, and communications devices are described that provide an antenna utilizing a fractal and/or self-similar conductive element that is novel and inventive in that its small in size and exhibits multiple-band or wideband frequency coverage which allows a miniature communications device incorporating the antenna to operate (e.g., function) with wide-band capabilities in close-proximity to a user's body and in form factor suitable for wearing by the user. As noted above, previous size and performance limitations of prior art antennas/devices were poor and made those devices either of limited utility or inoperable.
Patent CA-2991567-A1 (CA)
Inventor: HAYES GEORGE
IPC: H01G11/10
Filed: 2018-01-10
Abstract: In an embodiment, an impressed current cathodic protection system includes at least one parallel-charge, serial-discharge supercapacitor bank to increase the duty cycle of the system. In another embodiment, the output of the parallel-charge, serial-discharge supercapacitor bank is applied to an anode using pulse width modulation to apply the correct amount of current to maintain a mesh potential at a desired value. In yet another embodiment, an impressed current cathodic protection system includes a microcomputer controller configured to maximize efficiency of the system.
Patent CA-2994984-A1 (CA)
Title: Catalyseur d'hydrocraquage de distillats moyens contenant de la zeolite beta a faible acidite od et grande taille de domaine
Inventor: ZHANG YIHUA
IPC: B01J29/70
Filed: 2016-08-09
Abstract: La présente invention concerne un catalyseur d'hydrocraquage comprenant : a. de 0,5 à 10 % en poids de zéolite bêta présentant une acidité OD de 20 à 400 µmol/g et une taille moyenne de domaine comprise entre 800 à 1500 nm2 ; b. de 0 à 5 % en poids de zéolite USY présentant un ASDI entre 0,05 et 0,12 ; un poids en % de la zéolite bêta est supérieur au poids en % de la zéolite USY ; c. un support de catalyseur ; et d. au moins un métal choisi dans le groupe constitué d'éléments du groupe 6 et des groupes 8 à 10 du tableau périodique. La présente invention concerne un procédé d'hydrocraquage à l'aide du catalyseur d'hydrocraquage pour produire des distillats moyens. La présente invention concerne également un procédé de fabrication du catalyseur d'hydrocraquage.
Patent CA-2995722-A1 (CA)
Inventor: HAGEDOORN MICHIEL
IPC: G06T19/00
Filed: 2016-08-17
Abstract: The present invention relates generally to computer graphics applications, and more particularly to systems and methods for implementing two- and three-dimensional computer graphics modeling and animation of deformable objects in a simulated environment. More preferably, the present invention relates to computer or visual graphics applications using finite-element based and other physically based modeling or simulation methods.
Patent CA-2998297-A1 (CA)
Title: Association pharmaceutique pour convertir une cellule neoplasique en cellule non-neoplasique et ses utilisations
Inventor: ZOUANI OMAR F
IPC: A61K31/70
Filed: 2016-09-15
Abstract: La présente invention concerne une association pharmaceutique comprenant au moins un composé de liaison au récepteur du facteur de croissance, qui active au moins un récepteur du facteur de croissance d'une cellule néoplasique, et au moins un inhibiteur de protéine d'adhésion qui inhibe au moins une protéine d'adhésion cellulaire transmembranaire de ladite cellule néoplasique.
Patent CA-3000511-A1 (CA)
Inventor: GRUSCHOW ROBERT
IPC: B60K17/16
Filed: 2016-11-02
Abstract: La présente invention concerne un différentiel de véhicule relié à et agencé de façon à se déplacer avec un bras de commande et/ou un bras d'un ensemble de suspension, de sorte à former un système flottant de suspension de différentiel. Le différentiel est conçu pour être monté indépendamment par rapport au châssis de véhicule. Les avantages d'un système flottant de suspension de différentiel comprennent un meilleur alignement entre le différentiel et la boîte de transfert, un déplacement réduit de l'arbre d'entraînement dans la direction verticale, une plongée minimale sur les cannelures de l'arbre d'entraînement, une longueur d'essieu accrue avec une course de roue accrue, une modification réduite de l'angle de carrossage pendant la course de la roue, une construction abaissée du châssis avec une plage accrue de course de suspension, et un risque réduit de basculement du véhicule sans compromettre la portée de la course de suspension.
Patent CA-3000525-A1 (CA)
Inventor: HELFER WADE JONATHON
IPC: F16K1/22
Filed: 2016-10-07
Abstract: Valve body insert apparatus and related methods are described. An example valve includes a valve body made of a first material and having a fluid flow passageway and a first shaft bore. The fluid flow passageway defines a first axis and the first shaft bore defines a second axis that is substantially non-parallel relative to the first axis of the fluid flow passageway. A first insert is positioned in the first shaft bore. The first insert is made of a second material different than the first material such that the second material has a higher corrosion resistance characteristic than the first material.
Patent CA-3008084-A1 (CA)
Inventor: LINDER STIG
IPC: A61P35/00
Filed: 2016-12-10
Abstract: The invention provides well-defined and stable pharmaceutical compositions comprising indole derivatives of general formula 1, a process for the preparation of di-hydrochloride salts comprising a high content of the pharmacologically active isomer suitable for industrial production, and use of these in pharmaceutical compositions. The invention further provides a method for use of said compounds for the treatment of cancer. The invention also provides methods to use these compounds in conjunction with other therapies commonly used for treating cancer diseases.
Patent CA-3009089-A1 (CA)
Title: Sweeping blade device with adjustable blades
Inventor: MICHEL HUGO
IPC: E01H5/06
Filed: 2017-01-26
Abstract: A sweeping blade assembly for attachment to a vehicle for sweeping a ground surface. The sweeping blade assembly comprises: a blade support for receiving a plurality of blades, a first row of blades and a second row of blades. Each row of blade comprising a plurality of blades which are separated from each other by a gap. The first row of blades and the second row of blades are provided beside (and parallel to) each other and positioned so that a given gap in a given row corresponds to a blade in the other row. In an embodiment, the gap is dimensioned to be smaller in width than the blades whereby a given blade in one row can have a partial overlap of two different blades in the other row. Whereby, the blades can freely move vertically and/or angularly when hitting uneven surfaces, and can be rectangular in shape, and thus reversible when the carbide on one of the edges is worn out.
Patent CA-3010159-A1 (CA)
Title: Radio communication apparatus, radio communication system, and radio communication method
Inventor: OHTA YOSHIAKI
IPC: H04W72/04
Filed: 2010-02-12
Abstract: Using a plurality of frequency bands can be efficiently controlled. Wireless communication apparatuses (1, 2) communicate with each other using a plurality of frequency bands. During a random access procedure, the wireless communication apparatus (1) uses a first frequency band to transmit a control message, which includes identification information indicating a second frequency band different from the first frequency band, to the wireless communication apparatus (2). The wireless communication apparatus (2) receives the control message transmitted by use of the first frequency band from the wireless communication apparatus (1) and uses the second frequency band, which is indicated by the identification information included in the control message, to perform data communications.
Patent CA-3010556-A1 (CA)
Title: Device and method for damaging parasites using ultrasonic reflection
Inventor: COHEN MOR MIRI
IPC: A61L2/025
Filed: 2017-01-05
Abstract: A device for damaging a parasite while being on a surface of a body of a mammal. The device is a hand held device with an ultrasound transmitter for generating ultrasound radiation and a plurality of teeth extending from a base of the device and arranged alternately.
Patent CA-3012360-A1 (CA)
Title: Improved image analysis algorithms using control slides
Inventor: SARKAR ANINDYA
IPC: G06K9/00
Filed: 2017-03-01
Abstract: Systems and methods for automatically excluding artifacts from an analysis of a biological specimen image are disclosed. An exemplary method includes obtaining an immunohistochemistry (IHC) image and a control image, determining whether the control image includes one or more artifacts, upon a determination that the control image includes one or more artifacts, identifying one or more artifact regions within the IHC image by mapping the one or more artifacts from the control image to the IHC image, and performing image analysis of the IHC image where any identified artifact regions are excluded from the image analysis.
Patent CA-3013327-A1 (CA)
Inventor: RUSCONI CLERICI BELTRAMI ANDREA
IPC: H04R5/02
Filed: 2017-02-08
Abstract: The invention relates to an audio system (2) for arrangement in the outer region of an ear having a support element (4) that can be fitted to the head of the user and that has at least one hollow space (26, 27, 28) having a primary opening (11, 12, 13) that, when the support element (4) is arranged properly, is oriented in the direction of an ear opening (22) of the ear intended for that purpose, and having at least one loudspeaker (5, 6, 7) that is arranged in the hollow space (26, 27, 28), whose cavity (14, 15, 16) is formed at least in part by a first hollow space region (29) and by means of which first sound waves (35) can be emitted via the primary opening (11, 12, 13) in the direction of the ear at a distance. According to the invention, the hollow space (26, 27, 28) has a secondary opening (17, 18, 19) arranged in the first hollow space region (29) such that said secondary opening, when the support element (4) is arranged properly, is oriented away from the ear into the surroundings, so that the loudspeaker (5, 6, 7) can be used to emit, via the secondary opening (17, 18, 19), second sound waves (36) that have a phase offset in relation to the first sound waves (35) such that the volume of the sound waves delivered to the surroundings by the audio system (2) can be reduced.
Patent CA-3016011-A1 (CA)
Title: Dispositif terminal et programme de reecriture logicielle
Inventor: MATSUO MASAKI
IPC: B60R16/02
Filed: 2017-02-20
Abstract: Dans la présente invention, un dispositif de commande : règle des premières informations de lecture dans un espace de réglage de mémoire lorsqu'un logiciel est mémorisé dans un premier espace mémoire ; mémorise un logiciel de mise à jour dans un deuxième espace mémoire lorsque le logiciel de mise à jour est écrit dans un troisième espace mémoire ; règle des secondes informations de lecture dans l'espace de réglage de mémoire ; règle les secondes informations de lecture dans l'espace de réglage de mémoire lorsque le logiciel est mémorisé dans le deuxième espace mémoire ; mémorise le logiciel de mise à jour dans le premier espace mémoire lorsque le logiciel de mise à jour est écrit dans le troisième espace mémoire ; et règle les premières information de lecture dans l'espace de réglage de mémoire. Un dispositif terminal écrit le logiciel de mise à jour dans le troisième espace mémoire.
Patent CA-3019741-A1 (CA)
Title: Thiazolino 2-pyridones a cycles fusionnes, leurs procedes de preparation et leur utilisation dans le traitement et/ou la prevention de la tuberculose
Inventor: STALLINGS CHRISTINA L
IPC: A61P31/06
Filed: 2017-04-07
Abstract: La présente invention concerne une combinaison comprenant : (i) un médicament contre la tuberculose, ou un sel de qualité pharmaceutique de celui-ci, et (ii) un composé de formule II, ou une combinaison de qualité pharmaceutique de celui-ci. La combinaison peut être utilisée dans le traitement et/ou la prévention de la tuberculose.
Patent CA-3021051-A1 (CA)
Title: Braking force control method and braking force control device
Inventor: SHIOZAWA YUUKI
IPC: B60T7/12
Filed: 2016-04-15
Abstract: A braking force control method detects a wheel speed (w) of a vehicle (1), generates a holding braking force for holding the stopped state of the vehicle (1), regardless of whether or not a brake (3) is operated by a driver of the vehicle (1), when it is determined that the vehicle (1) has stopped, based on the wheel speed (w) detected in the state in which a braking force is applied to the vehicle (1), and delays the period in which the holding braking force is generated, in accordance with the friction coefficient of a road surface in the traveling path of the vehicle (1).
Patent CA-3022617-A1 (CA)
Inventor: PENAZZI DAVIDE
IPC: B29C33/04
Filed: 2017-07-07
Abstract: L'invention porte sur un poinçon pour le moulage par compression de matière plastique pour former des capsules destinées à la fermeture de récipients, le poinçon comprenant une partie tige en acier et une partie tête en alliage de cuivre vissée sur ladite partie tige, une interface de séparation entre ladite partie tige et ladite partie tête comprenant un passage de gaz qui atteint une surface inférieure du poinçon délimitant une cavité de formation où se produit le moulage par compression de la matière plastique, et un canal interne à ladite partie tête communiquant avec ledit passage de gaz pour permettre l'extraction du gaz hors de la cavité de formation.
Patent CA-3024172-A1 (CA)
Title: High strength shaped aluminas and a method of producing such high strength shaped aluminas
Inventor: BARCLAY DAVID A
IPC: C09K8/80
Filed: 2017-05-22
Abstract: A method of producing high strength shaped alumina by feeding alumina power into an agglomerator having a shaft with mixers able to displace the alumina power along the shaft, spraying a liquid binder onto the alumina power as it is displaced along the shaft to form a shaped alumina, and calcining the shaped alumina. The shaped alumina produced having a loose bulk density of greater than or equal to 1.20 g/ml, a surface area less than 10 m2/g, impurities of less than 5 ppm of individual metals and less than 9 ppm of impurities in total, and/or crush strength of greater than 12,000 psi.
Patent CA-3025740-A1 (CA)
Inventor: BARBOUR ROBERT H
IPC: C10L10/04
Filed: 2009-10-01
Abstract: The present invention relates to fuel additives, fuel additive compositions and fuel compositions, as well as a method for fueling an internal combustion engine, providing reduced metal pick-up by fuels where the compositions of the present invention contain a hydrocarbon substituted with at least two carboxy functionalities in the form of acids or at least one carboxy functionality in the form an anhydride.
Patent CA-3028589-A1 (CA)
Title: Hemoglobin-targeted drug delivery for the treatment of cancer
Inventor: BROOKES STEVEN
IPC: A61K47/68
Filed: 2017-06-21
Abstract: The use of hemoglobin as a targeting carrier for drugs is disclosed. Such hemoglobin-drug complexes have utility in the treatment of cancer, in particular cancers of the liver and colon. Said drug is preferably a nucleoside analog, in particular floxuridine and is covalently attached to the hemoglobin in a molar drug ratio of between 1 and 20.
Patent CA-3034610-A1 (CA)
Inventor: CANTRELL ROBERT L
IPC: G01C23/00
Filed: 2017-08-29
Abstract: In some embodiments, methods and systems of defending a crop-containing area against crop-damaging pests include an unmanned aerial vehicle including a sensor that detects one or more pests in the crop-containing area and an output device configured to eliminate the pest from the crop-containing area. One or more docking stations configured to accommodate the UAV are provided. A computing device configured to communicate with the UAV and the docking station over a network is provided. The UAV is configured to send pest detection data captured by a sensor of the UAV while patrolling the crop-containing area. In return, the computing device is configured to send a signal to the UAV to indicate instructions to the UAV as to how to move or activate the output device in order to eliminate the detected pest from the crop-containing area.
Patent CA-3037377-A1 (CA)
Inventor: BERDY NICOLE
IPC: H04W48/18
Filed: 2017-10-09
Abstract: The disclosed technology is generally directed to device provisioning in an IoT environment. For example, such technology is usable in provisioning IoT devices to an IoT Hub. In one example of the technology, an identification message that includes information associated with identification of a first IoT device is received. The validity of the first IoT device is then verified. After the first IoT device is verified, based at least in part on the identification message, an IoT hub is selected from a plurality of IoT hubs. The first IoT device is then caused to be registered with the selected IoT hub.
Patent CA-3043434-A1 (CA)
Inventor: HARMS HENDRIK JOHANNES
IPC: A61B6/03
Filed: 2017-11-10
Abstract: The present disclosure relates to a method and a system for modelling a human heart and/or chambers and cavities therein, such as the left and right atrium, based on a plurality of emission tomography images, such as positron emission images, of said human heart, wherein each image represents concentrations of a tracer that has been injected at a specific time, the overall method comprising the steps of: A: extracting time activity curves of a tracer that has been injected for a plurality of pixels and/or voxels; B: identifying first-pass peaks of the time activity curves, each peak corresponding to an arrival time of the injected tracer at the corresponding pixel/voxel; C: defining a model comprising at least two portions of the heart, wherein the at least two portions are isolated by selecting pixels and/or voxels based on comparisons of the first-pass peaks against a threshold; and D: arranging the at least two portions in relation to each other by comparing the arrival times of the first-pass peaks of the pixels and/or voxels in the portions, thereby obtaining a segmented model of the human heart, which method and model may specifically be used to obtain an estimate of the volume of the left or right atrium of said human heart.
Patent CA-3050704-A1 (CA)
Title: Pressure compensated motor power lead connection for submersible pump
Inventor: SEMPLE RYAN
IPC: F04D13/06
Filed: 2018-01-18
Abstract: A well pump electrical motor has a motor housing filled with a dielectric motor lubricant. A motor head has at least one motor lead passage in fluid communication with the motor lubricant. An outer seal, which is exposed to well fluid, seals around a motor lead in the motor lead passage. An inner seal seals around the motor lead in the motor lead passage inward from the outer seal and has an inner side in contact with the motor lubricant in the motor. A barrier fluid passage extends into an annular space between the inner and outer seals and contains a barrier fluid. A pressure compensating device has an inner side in contact with the barrier fluid in the barrier fluid passage for reducing a pressure differential between the barrier fluid and a hydrostatic fluid pressure of well fluid on the exterior of the motor.
Patent CA-3051276-A1 (CA)
Inventor: ZOSO NATHANIEL
IPC: A61B5/103
Filed: 2017-01-25
Abstract: L'invention concerne un système et un procédé permettant de déterminer le profil de démarche d'un utilisateur. Le système de profilage de démarche utilise des systèmes de mesure qui comprennent des capteurs inertiels configurés pour être positionnés au niveau de la structure pied-cheville droite et gauche, ainsi que l'orientation spatiale de segments corporels d'extrémité inférieure (jambes, cuisses et tronc) de la personne pour laquelle le profil de démarche doit être déterminé. Dans un mode de réalisation illustratif, le système de profilage de démarche utilise deux capteurs inertiels supplémentaires au niveau de la structure jambe-genou ou cuisse-hanche gauche et droite ainsi que des capteurs fournissant des informations indiquant les positions angulaires du genou et de la cuisse gauches et droits, qui peuvent être fournies par un exosquelette ou des dispositifs d'orthèses portés par l'utilisateur. Cette détermination du profil de démarche de l'utilisateur est ensuite réalisée à l'aide d'informations biomécaniques sur l'utilisateur provenant des capteurs inertiels, combinées aux angles de genou et de hanche.
Patent CA-3051567-A1 (CA)
Title: Absorbent sheet having regenerated cellulose microfiber network
Inventor: SUMNICHT DANIEL W
IPC: D21H27/38
Filed: 2007-03-20
Abstract: An absorbent paper sheet for tissue or towel includes from about 99 percent to about 70 percent by weight of cellulosic papermaking fiber and from about 1 percent to about 30 percent by weight fibrillated regenerated cellulose microfiber which was regenerated form a cellulosic dope utilizing a tertiary amine N-oxide solvent or an ionic liquid. Fibrillation of the microfiber is controlled such that it has a reduced coarseness and a reduced freeness as compared with unfibrillated regenerated cellulose microfiber from which it is made and provides at least one of the following attributes to the absorbent sheet: (a) the absorbent sheet exhibits an elevated SAT value and an elevated wet tensile value as compared with a like sheet prepared without fibrillated regenerated cellulose microfiber; (b) the absorbent sheet exhibits an elevated wet/dry CD tensile ratio as compared with a like sheet prepared without fibrillated regenerated cellulose microfiber; (c) the absorbent sheet exhibits a lower GM Break Modulus than a like sheet having like tensile values prepared without fibrillated regenerated cellulose microfiber; or (d) the absorbent sheet exhibits an elevated bulk as compared with a like sheet having like tensile values prepared without fibrillated regenerated cellulose microfiber. In some embodiments, the pulp is pre-treated with debonder to enhance the wet/dry CD tensile ratio of the sheet.