Patent GB-908187-A (GB)
Title: New quinazolines
Inventor: BROWN JOSEPH PATRICK
IPC: C08K5/3465
Filed: 1960-04-21
Abstract: Sodium or potassium soaps, synthetic surface-active agents such as the sodium salt of a long-chain alkylated aromatic sulphonic acid, aqueous solutions or emulsions of soaps and surface active agents, waxes such as beeswax, carnauba wax and paraffin wax, and wax polishes are admixed with bacteriostatic compounds having two N3-(quinasolin-2-yl)-N1-guanidino groups linked by an aliphatic residue, or acid addition salts or quaternary derivatives thereof. Either or both of the quinasoline groups may be substituted in the benzene ring by chlorine, bromine or iodine, or by an alkyl, aryl, aralkyl, hydroxyl, nitro, alkoxy or amino group, while the 4-position of the heterocyclic ring may be substituted by an alkyl or cycloalkyl group.  The aliphatic linking residue may be an alkylene chain which is optionally substituted by an alkyl, aryl, hydroxyl or alkoxy group.ALSO:Polystyrene, polyvinyl chloride, polyethylene, phenol resins and melamine resins are protected from bacterial and fungal attack by admixture with from 0,05% to 5% by weight of compounds having two N3-(quinazolin-2-yl)-N1-guanidino groups linked by an aliphatic residue, or acid addition salts or quaternary derivatives thereof.  Either or both of the quanazoline groups may be substituted in the benzene ring by chlorine, bromine or iodine, or by an alkyl, aryl, aralkyl, hydroxyl, nitro, alkoxy or amino group, while the 4-position of the heterocyclic ring may be substituted by an alkyl or cycloalkyl group.  The aliphatic linking residue may be an alkylene chain which is optionally substituted by an alkyl, aryl, hydroxyl or alkoxy group.ALSO:The invention comprises compounds having two N3-(quinazolin-2-yl)-N1-guanidino groups linked by an aliphatic residue, or acid addition salts or quaternary derivatives thereof. Either or both of the quinazoline groups may be substituted in the benzene ring by chlorine, bromine or iodine, or by an alkyl, aryl, aralkyl, hydroxyl, nitro, alkoxy or amino group, while the 4-position of the heterocyclic ring may be substituted by an alkyl or cycloalkyl group.  The aliphatic linking residue may be an alkylene chain which is optionally substituted by an alkyl, aryl, hydroxyl or alkoxy group.  The above compounds are prepared by reacting a salt of a 2,2-dialkyl-1,2-dihydroquinoline with a compound having two N3-cyano-N1-guanidino groups linked by an aliphatic residue.  Acid addition salts are formed with hydrochloric, hydrobromic and acetic acids.  Quaternary ammonium derivatives are obtained by heating the free base with an alkyl halide or an alkylene dihalide, the latter yielding cyclic derivatives.ALSO:A bacteriostatic composition having both bactericidal and fungicidal properties comprises an aqueous or organic solution, suspension or emulsion; a lotion, paste, cream or ointment; an aerosol or a finely divided solid containing as the active ingredient a compound having two N3-(quinazolin-2-yl)-N1-guanidino groups linked by an aliphatic residue, or an acid addition salt or a quaternary derivative thereof. Either or both of the quinazoline groups may be substituted in the benzene ring by chlorine, bromine or iodine, or by an alkyl, aryl, aralkyl, hydroxyl, nitro, alkoxy or amino group, while the 4-position of the heterocyclic ring may be substituted by an alkyl or cycloalkyl group.  The aliphatic linking residue may be an alkylene chain which is optionally substituted by an alkyl, aryl, hydroxyl or alkoxy group.