baber/WOPTO huggingface dataset:
Patent BR-122017024057-B8 (BR)
Title: anticorpo que se liga à c5 e composição farmacêutica compreendendo dito anticorpo e um veículo farmaceuticamente aceitável
Inventor: LEODARD BELL
IPC: A61K31/7105
Filed: 2007-03-15
Abstract: eculizumab, um anticorpo monoclonal humanizado contra c5 que inibe a ativação do complemento terminal, mostrou atividade em uma triagem de marcação aberta de 12 semanas preliminar em um pequeno grupo de pacientes com hemo-globinúria paroxística noturna (hpn). o presente estudo examinou se a terapia crônica com eculizumab pode reduzir hemólise intravascular, estabilizar níveis de hemoglobina, reduzir requerimentos de transfusão, e melhorar a qualidade de vida em uma triagem global de fase iii do tipo duplo-cego, aleatória, placebo-controlado, multi-cêntrica. tem sido encontrado que eculizumab estabilizou os níveis de hemo-globina, diminuiu a necessidade de transfusões, e melhorou a qualidade de vida em pacientes hpn através de uma via de hemólise intravascular reduzida. trata-mento crônico com eculizumab aparenta ser uma terapia segura e eficaz para pnh.
Patent BR-122019016866-B8 (BR)
Title: método para avaliar (analisar) o risco dos efeitos adversos potenciais para um paciente humano mediados pela administração de um anticorpo biespecífico de cd19xcd3
Inventor: DIRK NAGORSEN
IPC: C07K16/46
Filed: 2010-10-27
Abstract: uso de anticorpo biespecífico de cd19xcd3 no tratamento de linfócitos cd19-positivos malignos em um paciente humano tendo uma razão de células b:t de cerca de 1:5 ou menor. a presente invenção refere-se a um método para avaliar (analisar) o risco dos efeitos adversos potenciais para um paciente humano mediados pela administração de um anticorpo biespecífico de cd19xcd3 ao dito paciente compreendendo determinar a razão de células b para células t do dito paciente, em que uma razão de cerca de 1:5 ou menor é indicativo para um risco de efeitos adversos potenciais para o dito paciente. consequentemente, a presente invenção refere-se a um método (regime de dosagem) para administrar um anticorpo biespecífico de cd19xcd3 a um paciente humano tendo uma razão de células b:t de cerca de 1:5 ou menor, compreendendo (a) administrar uma primeira dose do dito anticorpo durante um primeiro período de tempo; e consecutivamente (b) administrar uma segunda dose do dito anticorpo durante um segundo período de tempo, em que a dita segunda dose excede a dita primeira dose. um pacote ou kit farmacêutico compreendendo uma primeira dose e uma segunda dose e opcionalmente uma terceira dose do dito anticorpo como definidas nos métodos/regime de dosagem da presente invenção é também revelado.
Patent DE-19983745-B9 (DE)
Title: Verwendung von Seitenetikettregistern um einen Zustand von physikalischen Seiten in einer Speichervorrichtung zu verfolgen
Inventor: STRACOVSKY HENRY
IPC: G06F12/02
Filed: 1999-11-15
Granted: 2012-11-08
Abstract: Ein Verfahren zum Beschleunigen eines Speicherzugriffs einer Speicherseite, die in einer Speicherbank in einem Mehrbanktypspeicher (908) enthalten ist, durch eine Speichersteuerung (904) ist beschrieben. Eine ankommende Systemadreßanforderung wird von der Speichersteuerung (904) empfangen, die eine angeforderte Bankzahl und eine angeforderte Seitenzahl umfaßt. Eine Seitenregisterzahl entsprechend der angeforderten Bank wird dann lokalisiert, wonach die gespeicherte Seitenadresse, die in dem lokalisierten Seitenregister enthalten ist, mit der angeforderten Seitenadresse verglichen wird. Auf die angeforderte Seite in der Speicherbank entsprechend der angeforderten Bankzahl wird dann zugegriffen, wenn die gespeicherte Seitenadresse mit der angeforderten Seitenadresse für die angeforderte Speicherbank übereinstimmt.
Patent EP-1204856-B9 (EP)
Inventor: SCHAWALLER MANFRED
IPC: G01N21/55
Filed: 2000-08-18
Granted: 2005-12-07
Abstract: This invention relates to a method for the determination of substances using the evanescence field method. A cuvette, a microtiter well, a solution and a kit for application in a method according to the invention are disclosed. This method can in particular be used in the field of diagnostics and in analytical procedures.
Patent EP-1338657-B9 (EP)
Inventor: COLE STEWART
IPC: C12Q1/68
Filed: 2002-02-25
Granted: 2007-10-10
Abstract: The present invention is the identification of a nucleotide sequence which make it possible in particular to distinguish an infection resulting from Mycobacterium tuberculosis from an infection resulting from Mycobacterium africanum, Mycobacterium canetti, Mycobacterium microti, Mycobacterium bovis, Mycobacterium bovis BCG. The subject of the present invention is also a method for detecting the sequences in question by the products of expression of these sequences and the kits for carrying out these methods. Finally, the subject of the present invention is novel vaccines.
Patent EP-1449850-B9 (EP)
Inventor: SHITARA KENYA
IPC: G01N33/68
Filed: 2002-08-30
Granted: 2011-05-11
Abstract: A human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of human CC chemokine receptor 4 (CCR4) but does not react with a human blood platelet; a human CDR-grafted antibody or the antibody fragment thereof which specifically reacts with the extracellular region of CCR4 and has a cytotoxic activity against a CCR4-expressing cell; and a medicament, a therapeutic agent or a diagnostic agent comprising at least one of the antibodies and the antibody fragments thereof as an active ingredient.
Patent EP-1467933-B9 (EP)
Inventor: GENETRE ERIC
IPC: B65F1/06
Filed: 2002-12-19
Granted: 2006-06-28
Abstract: The invention concerns a device for dividing a receptacle into compartments for sorting, arranged on the opening of the receptacle and designed to maintain at least an open bag, comprising a crosspiece consisting of at least two telescopic elements (1, 2) formed by profiled sections with matching shape to ensure that they slide with longitudinal guidance, the profiled section forming each element consisting of a body having a part with large cross-section (4, 10) which is mounted on a part with narrower cross-section (5, 11) at the base of which is provided, forming a single piece therewith, on its two sides and over its entire length, means for catching and locking the bags to be maintained.
Patent AU-2004297136-B9 (AU)
Title: Image, recording method, information recognition method, and information recognition system
Inventor: IKEDA MASAMI
IPC: C09D11/00
Filed: 2004-12-13
Granted: 2011-05-12
Abstract: To provide an image or the like which can easily record a large amount of information without the lamination of a large number of colorant layers, and which hardly allows forgery, alteration, or the like. Provided is an image formed by overlapping multiple ink layers, in which a first ink layer is formed on a recording material by means of a first ink having fluorescent emission property, a second ink layer is formed on the first ink layer by means of a second ink, and the first ink layer is exposed in a dotted manner on the second ink layer.
Patent AU-2006306553-B9 (AU)
Title: Anti-ADDL monoclonal antibody and use thereof
Inventor: GENE KINNEY
IPC: A61K39/395
Filed: 2006-10-17
Granted: 2011-09-29
Abstract: The present invention relates to antibodies that -differentially -recognize- -multi- dimensional conformations- of- Aβ- derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
Patent AU-2014341049-B9 (AU)
Title: Panel body
Inventor: TSUCHIYAMA WAKU
IPC: E04B2/74
Filed: 2014-10-31
Granted: 2018-06-21
Abstract: A panel body (11) comprises: a panel-shaped base material (12); a groove (25) that is continuous with at least a portion of the outer circumferential end of the base material (12) and that is recessed toward the interior of the base material (12); a soft material (13) that is provided on at least one face of the base material (12); a cover material (14) that covers the base material (12) and the soft material (13) and for which the outer circumferential end thereof is enfolded into the groove (25) on the outer circumferential edge of the base material (12); and a fixing means (30) that fixes the cover material (14) in the groove (25).
Patent AU-2018274599-B9 (AU)
Title: Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
Inventor: NAEF RETO
IPC: A61P3/10
Filed: 2018-05-22
Granted: 2022-04-07
Abstract: The present invention relates to compounds of formula I or pharmaceutically acceptable salt, solvate or hydrate thereof and their use in methods of treating or preventing a disease alleviated by inhibition of PDE5 in a human or in a non-human mammal.
Patent DE-3225815-C1 (DE)
Title: Ratchet-like open-jaw spanner
Inventor: NITSCHMANN FRED-WERNER DIPL-IN
IPC: B25B13/46
Filed: 1982-07-09
Granted: 1983-12-29
Abstract: An automatic open-jaw spanner is described, which has a two-part jaw, one part of the jaw being firmly connected to the spanner body and the other part being movably guided in the latter. The open-jaw spanner has, furthermore, an unlockable blocking device, by means of which the movable part of the open-jaw spanner can be rested in a working position. The open-jaw spanner according to the invention provides a flexible, efficiently usable and, above all, automatically regripping quick-acting open-jaw spanner, which works in a similar way to known short box ratchet spanners.
Patent DE-3447098-C1 (DE)
Inventor: DALLMER JOHANNES ING
IPC: E03C1/284
Filed: 1984-12-22
Granted: 1986-03-20
Abstract: 1. Concealed siphon having the following features : - it has a housing with a rectangular cross section, at the upper end of which a short feed pipe with a horizontal axis and at the bottom side of which a discharge pipe with a vertical axis are integrally formed ; - the interior space of the housing is divided by means of an immersion wall and a retaining wall into three parallel channels, namely in - a first channel leading from the short feed pipe into the lower region of a reservoir, - a second channel leading from the lower region of the reservoir to the upper edge of a retaining wall and - a third channel leading from the upper edge of the retaining wall into the discharge pipe, - the three channels being arranged adjacent to one another in the housing (10) ; characterised by the following features : - the first channel is formed by a hose (21) which is firmly connected to the end of a couplable supply pipe (12) and supported at a wall (10a) of the housing.
Patent DE-3641899-C1 (DE)
Title: Electro-ultrafiltration method with continuously increasing filtration efficiency and stepwise establishment of maximum current strengths for analysing the nutrients or the pollutants in soils, composted waste, sewage sludge etc.
Inventor: NEMETH KALMAN DIPL-ING DR
IPC: B01D35/06
Filed: 1986-12-08
Granted: 1988-04-07
Abstract: In the electro-ultrafiltration methods for analysing the nutrients fractions of soils, interferences occur which can lead to an under estimation of readily available nutrient contents and to an overestimation of the nutrient reserves of lime-rich soils, as a result of which excessive or insufficient fertiliser rates are recommended. To avoid these interferences, according to the invention it is proposed to limit the maximum mA values during the ultrafiltration stepwise (0-30 min at 15, 30-35 min at 40 and 35-40 min at 150 mA). The advantages achievable by the novel method of establishing the mA values stepwise are in particular that the readily available nutrient contents, chiefly phosphorus contents, of lime-rich soils not determined at 15 mA values can be obtained at mA values of </= 40 and that the potassium reserves of lime-rich soils are still not overestimated at mA values of 40, so that K-selective minerals of the soils can be determined exactly.
Patent DE-3642301-C1 (DE)
Inventor: KORDTS HUGO ING
IPC: B27M3/00
Filed: 1986-12-11
Granted: 1988-01-14
Abstract: In the hitherto existing pallet manufacturing machine, it is necessary for the covering and transverse boards to be assembled together on the nailing template, thereby greatly impairing the productivity of the nailing machine. According to the invention, it is proposed to assemble together the unit consisting of transverse boards and covering boards outside the nailing template, specifically on a so-called assembly platform, and then to transfer the so assembled unit onto the nailing template via a gripper or a similar transport device, so that the nailing machine can work with higher productivity. <IMAGE>
Patent DE-3731976-C1 (DE)
Title: Flame-cutting machine, equipped with a water cooling system, for cutting workpieces, in particular continuous castings
Inventor: HERBENER KLAUS
IPC: B23K37/00
Filed: 1987-09-23
Granted: 1988-09-22
Abstract: Flame-cutting machines for continuous castings are exposed to the torch and casting working temperatures occurring during operational use and have to be cooled by a water-circulation cooling system. In order to reduce the subassemblies attached to the water-circulation cooling system, a cooling trough (1) which can be filled with cooling water is arranged on the flame-cutting machine in an area running essentially parallel to the continuous casting (Fig. 3). <IMAGE>
Patent DE-3840542-C1 (DE)
Title: Process for producing a thin-walled, thermoformed plastic moulding and its use
IPC: F21S8/00
Filed: 1988-12-01
Granted: 1989-11-02
Abstract: In a process for producing a thin-walled, thermoformed plastic moulding, planar cold-stretchable film material at a predetermined operating temperature is subjected to a fluid pressure medium and isostatically shaped. To reduce considerably the cycle time required for production, the shaping of the film material is performed at an operating temperature below the softening temperature of the film material and under a pressure medium pressure of greater than 20 bar. Preferably, a planar, cold-stretchable film material which is additionally provided with at least one colour imprint is shaped. In this case, an operating temperature above 80@C and below the softening temperature of the film material is chosen and, for the colour imprint, an ink whose ink carrier is deformable at this operating temperature is chosen, and the shaping of the film material takes place under a pressure medium pressure of greater than 20 bar. Dimensionally stable, multicoloured plastic mouldings are obtainable by injecting plastic onto the inside wall of the thermoformed plastic moulding produced in this way.
Patent DE-3917412-C1 (DE)
IPC: C02F1/52
Filed: 1989-05-29
Granted: 1990-12-13
Abstract: The description relates to a composition for treating water containing metal ions and possibly additional organic and/or inorganic impurities which is obtainable by the conversion of sulphur with an alkaline and/or alkaline earth hydroxide in the presence of water. The composition of the invention may be used together with an inorganic compound containing a polyvalent cation and is added to the water to be purified containing soluble metal ions and possibly organic and/or inorganic impurities, whereby the pH is set to values ranging from 2 to 12.
Patent DE-3918731-C1 (DE)
Title: Sprue and distribution system for mould mfr. - comprises sprue connected to upper and lower runners, etc.
IPC: B22C9/08
Filed: 1989-06-08
Granted: 1990-11-08
Abstract: In a sprue and distribution system for mfr. of a mould for castings, the sprue (10) is connected to an upper (14) and a lower (12) runner, the parts being partly joined together by circular contact areas (18,20), which form ring-shaped gaps with relatively narrow cross sections. These restrict the flow of molten metal into the mould. Upper and lower runners are trapezoidal in section and are rotationally symmetrical and concentric to one another.  The runner outlet (16) is connected to the upper runner. ADVANTAGE - Laminar flow is promoted and inclusions retained.
Patent DE-4025409-C1 (DE)
Title: Cable roller for drum - has slip-rings separated by insulating spacers from hub
IPC: H02G11/02
Filed: 1990-08-10
Granted: 1991-11-28
Abstract: A cable reeling appts. has a fixed boss (1) which carries a hub (2) on which a rotating cable drum (21) is mounted. Between hub (2) and cable drum (21) a cylindrical insert (19) carries pairs of slip-rings (26, 27) separated by insulating distance pieces (23). The slip-rings (26, 27) are contacted by radially set plug contacts (32) as well as similar contacts (33) aligned in an axial direction. Access to the axial contacts (33) which pass through channels (7, 71) in the boss (1) is achieved via a hollow chamber (6) in the boss (1). USE/ADVANTAGE - Makes use of small number of preassembled parts including slip-rings which can be precisely assembled on axial hub. Permits convenient plug connections to both fixed and moving conductors or multi-polar system.
Patent DE-4034736-C1 (DE)
Title: Junction pipe in mine shaft - incorporates cross-block with square outlet
IPC: F16L43/00
Filed: 1990-10-30
Granted: 1992-01-30
Abstract: The junction pipe fitting with a soil connection is fitted into a pipe run along the shaft of a mine. The main pipe (19) of the junction (18) has a cross block (20), and in both the sections thus created is a square outlet (21,21'). The junction (18) is in one piece the mould for which is of mechanically made wrought iron. Alternatively the mould can be a welded construction of pairs of components. USE/ADVANTAGE - Junction pipe in shaft or mine. Can be associated with the main run in various positions.
Patent DE-4100007-C1 (DE)
Title: Salt scattering machine, for dough baking - comprises feeding-, moistening- and coating-stations, coating material containers, and drive gears, for sesame seed compact storage
IPC: A21C9/04
Filed: 1991-01-02
Granted: 1992-05-14
Abstract: Machine has a feeding station with belt on to which the dough pieces are turned and placed and a moistening station for damping the surfaces to be coated, with a turning device for turning the dough pieces through 180 deg. A coating station comprises several coating material containers, one after the other, each of which has a drive gear, which can be engaged with a main drive gear for movement forwards and backwards wrt machine frame. ADVANTAGE - Simple change-over.
Patent DE-4131663-C1 (DE)
Title: Tooth bite model used in dentistry - has flat horizontal baseplate with large number of cylindrical or tapered pre-drilled blind bores to accommodate pins
IPC: A61C9/00
Filed: 1991-09-23
Granted: 1993-04-08
Abstract: The tooth bite model uses a tray-impression cast and a transparent bearing plate whose pre-drilled holes are allocated to single teeth, stumps and/or gaps and are fitted with pins to penetrate the as yet-unhardened cast in the impression when the model and plate are joined up. The bearing plate should consist of a horizontal baseplate (6) with predrilled dead-end holes (7). Once they have pierced the holes, the pins are fixed in bearing sleeves (8) located in the holes. The holes (7) are cylindrical or else taper towards their lids and the bearing sleeves (8) are adapted in OD to the hole dia. USE/ADVANTAGE - Tooth bite model used in dentistry, and dental laboratories. Pins are locked in holes in precise alignment prior to cast entry.
Patent DE-4138221-C1 (DE)
Title: Integrated optical sensor for absolute measurement of gaseous refractive indices - has several measurement regions each covered by film sensitive to specific gas, transducer, and wave guide
IPC: G01N21/41
Filed: 1991-11-21
Granted: 1993-04-29
Abstract: The optical sensor has several similar measurement regions (M1-M3) on a single lithium niobate substrate body (2), each with a film (16-18) with specific sensitivity to a defined gas, and an electroacoustic transducer. At least one film also extends over a section of optical waveguide (4) with a no proton exchange layer and which serves as a reference region (R1) for deriving a correction signal. The measurement and reference regions are arranged in sequence along the optical waveguide. Guide layers (13, 13') in the substrate on either side of the waveguide form a monomode acoustic waveguide extending in the direction of propagation of acoustic waves at least over the measurement and reference regions. USE/ADVANTAGE - Sensor can simultaneously determine absolute refractive indices of several gases with extremely high accuracy.
Patent DE-4241648-C1 (DE)
Inventor: HABLOV DIMITRI VLADIMIVOVIC
IPC: G01S7/02
Filed: 1992-12-04
Granted: 1994-09-01
Abstract: The invention relates to an electronic monitoring system, in particular for monitoring buildings, for determining the presence of unauthorised persons by means of a microwave transmitting/receiving device (9) for generating a microwave field and for irradiating therewith the area to be monitored. The microwave device (9) also serves to register the microwave signal which is reflected from the monitored region and modulated, when living beings are present in the region, with frequencies which correspond to the life functions of said living beings, and has a first signal processing device (903 to 919). The electronic monitoring system further has a signal processing device (10) for providing an actual signal amount (10.1), a first storage device (2) for storing and emitting at least one specimen signal amount (2.1, 2.3) which describes a normal state of the area to be monitored, that is to say the absence of unauthorised persons, and a comparator unit (11) for comparing with each other the actual signal amount (10.1) provided by the microwave transmitter (9.2) and the at least one specimen signal amount (2.1, 2.3) emitted by the storage device (2), which comparator unit (11) emits an output value amount (11.1) characterising the result of the comparison, the comparator unit (11) being connected to the display device (7). <IMAGE>
Patent DE-4331199-C1 (DE)
Title: Component with light source holder
Inventor: RECHL RUDOLF
IPC: F21V7/00
Filed: 1993-09-14
Granted: 1995-03-30
Abstract: A component 2 is shown with a light source holder 4 for fitting in or on a wall 8 or a supporting element in buildings, characterised by a depression 10 and a diaphragm element 12 which partly covers the depression 10, the light source holder 4 being arranged in the covered region of the depression 10. <IMAGE>
Patent DE-4415054-C1 (DE)
Title: Control for hydraulic drive
Inventor: EWALD ROLAND
IPC: F15B21/08
Filed: 1994-04-29
Granted: 1995-05-24
Abstract: An electrical signal for controlling the valve is given from a computer unit which works at high speed, and in which a valve theoretical value is calculated for the movement of the drive. As simulated situation dimension at least the pressure (PA,PB) ruling between the valve and the work chamber (AA,AB) of the drive (Z) is used for calculating the actual theoretical value. The pressure difference of the work fluid between forward and back flow to the drive as simulated situation dim. forms the basis of the calculation of the actual theoretical value. To the simulated situation dimension further pressure values are calculated for the length of the time constant of the system and the simulated values are added on.