baber/WOPTO huggingface dataset:
Patent CA-2376797-A1 (CA)
Title: Administration of non oral androgenic steroids to women
Inventor: MAZER NORMAN A
IPC: A61K31/58
Filed: 2000-06-09
Abstract: The present invention provides compositions, methods, and kits for improving  health in a woman having elevated sex hormone binding globulin (SHBG) levels , or who is receiving oral estrogen supplementation, by non-orally administeri ng an effective amount of an androgenic steroid. Further, the present invention  provides compositions, methods and kits for coadministering an effective amount of an orally administered estrogen and an effective amount of a non- orally administered androgenic steroid for women in need of estrogen supplementation. Fig. 1 shows the change in total testoterone level versus baseline SHBG level during application of transdermal testoterone patch (300  mcg/day nominal delivery) to patients concomitantly receiving transdermal estradiol or oral conjugated equine estrogens. Fig. 2 shows the change in fr ee testoterone level versus baseline SHBG level during application of transderm al testosterone patch (300 mcg/day nominal delivery) to patients concomitantly receiving transdermal estradiol or oral conjugated equine estrogens.
Patent CA-2378497-A1 (CA)
Title: Recombinant parainfluenza virus vaccines attenuated by deletion or ablation of a non-essential gene
Inventor: COLLINS PETER L
IPC: A61K39/00
Filed: 2000-07-06
Abstract: Recombinant parainfluenza virus (PIV) are provided in which expression of th e C, D and/or V translational open reading frame(s) (ORFs) is reduced or ablat ed to yield novel PIV vaccine candidates. Expression of the C, D and/or V ORF(s ) is reduced or ablated by modifying a recombinant PIV genome or antigenome, f or example by introduction of a stop codon, by a mutation in an RNA editing sit e, by a mutation that alters the amino acid specified by an initiation codon, o r by a frame shift mutation in the targeted ORF(s). Alternatively, the C, D and/or V ORF(s) is deleted in whole or in part to render the protein(s) encoded thereby partially or entirely non-functional or to disrupt protein expression altogether. C, D and/or V ORF(s) deletion and knock out mutants possess highly desirable phenotypic characteristics for vaccine development.  These deletion and knock out mutations changes specify one or more desired phenotypic changes in the resulting virus or subviral particle. Vaccine candidates are generated that show a change in viral growth characteristics,  attenuation, plaque size, and/or a change in cytopathogenicity, among other novel phenotypes. A variety of additional mutations and nucleotide modifications are provided within the C, D and/or V ORF(s) deletion or ablation mutant PIV of the invention to yield desired phenotypic and structural effects.
Patent CA-2378657-A1 (CA)
Title: Identification and overexpression of a dna sequence coding for 2-methyl-6-phytylhydroquinone-methyltransferase in plants
Inventor: BADUR RALF
IPC: C12N15/31
Filed: 2000-06-23
Abstract: A method for the prdouctin of plants with an increased tocipherol and tocotrienol content by overexpression of a gene coding for 2-methyl-6-phytylhydroquinone-methyltransferase.
Patent CA-2383615-A1 (CA)
Inventor: GAIGER ALEXANDER
IPC: A61K39/395
Filed: 2000-09-22
Abstract: The present invention is directed to methods for detecting and treating hematological and virus-associated malignancies using Her2/neu sequences. The Her2/neu sequences may be polypeptides or polynucleotides.
Patent CA-2383988-A1 (CA)
Inventor: PINNEY KEVIN G
IPC: A61P35/02
Filed: 2000-09-15
Abstract: L'invention concerne des ligands indoliques substitués par triméthoxyphényle, qui présentent une cytotoxicité impressionnante ainsi qu'une remarquable capacité d'inhiber la polymérisation de la tubuline. Ces composés, ainsi que les dérivés qui leur sont associés, sont d'excellents candidats cliniques pour le traitement du cancer chez l'homme. De plus, certains de ces ligands, utilisés comme promédicaments, peuvent être des agents chimiothérapeutiques de ciblage et de destruction vasculaires sélectifs d'une tumeur, ou posséder une action anti-angiogénique donnant lieu à la prévention et/ou destruction sélective du système vasculaire d'une cellule tumorale.
Patent CA-2385898-A1 (CA)
Inventor: KOTAKI YASUO
IPC: B65D77/26
Filed: 2002-05-10
Abstract: A package includes a packaging member; and an ink container which contains ink comprising pigment coloring material and solvent dispersing the coloring material and which has an ink supply port for permitting supply of the ink to an outside, wherein the ink container is mountable to an ink jet recording apparatus with the ink supply port at a lower position, the ink container accommodating an ink absorbing material for absorbing the ink and being provided with an air vent which is open for fluid communication between a space inside the ink container and ambience, and wherein a region tending to have a high coloring material density in the ink container is at a position generally diagonally opposite the ink supply port, wherein the ink container is in a first orientation which is different from a second orientation taken in use in the ink jet recording apparatus.
Patent CA-2387316-A1 (CA)
Title: Method and apparatus for the detection of noncovalent interactions by mass spectrometry - based diffusion measurements
Inventor: KONERMANN LARS
IPC: H01J49/04
Filed: 2002-05-31
Abstract: The present invention provides a method and apparatus for detecting the noncovalent binding of a potential ligand (such as a drug candidate) to a target molecule, e.g. a biochemical macromolecule such as a protein. The method is based on the Taylor dispersion of an initially sharp boundary between a carrier solution, and an analyte solution that contains the potential ligand(s) and the target molecule.  Dispersion profiles of one or more potential ligands are monitored by mass spectrometry at the exit of the laminar flow tube. Potential ligands will usually be relatively small molecules that have large diffusion coefficients. In the absence of any noncovalent interactions in solution, very steep dispersion profiles are expected for these potential ligands.  However, a ligand that binds to a large target molecule in solution, will show a diffusion coefficient that is significantly reduced, thus resulting in a less steep dispersion profile.  Noncovalent binding can therefore be detected by monitoring dispersion profiles of potential ligands in the presence and in the absence of the target molecule. In contrast to other mass spectrometry-based methods for detecting noncovalent interactions, this method does not rely on the structural integrity of the complex in the gas phase. This method has an excellent sensitivity and selectivity, therefore it can be used for testing multiple potential ligands simultaneously. The method is therefore useful for the screening of compound libraries.
Patent CA-2387732-A1 (CA)
Title: Pull throughs
Inventor: GALANTAI RODERICK FRANCIS
IPC: A61B19/00
Filed: 2000-10-12
Abstract: A pull through comprising a filament (1) having at least a thermoplastics surface, and a moulded thermoplastic mass (2) about said filament defining a pull through profile adapted for the purpose of the pull through, wherein the filament (1) is a monofilament (whether of the one material or otherwise) sufficiently stiff to enable its threading through a conduit, passageway or the like of a member (e.g.; endoscope) for which it is adapted or intended for use, and wherein said moulded thermoplastic mass (2) is of a material of lower melting point than at least part of said filament (1). A method of manufacturing said pull through is also disclosed.
Patent CA-2388610-A1 (CA)
Inventor: CROFT JED
IPC: A61K47/32
Filed: 2000-10-12
Abstract: The present invention is directed toward formulation and method for oral transmucosal delivery of a pharmaceutical. The invention provides a drug formulation comprising a solid pharmaceutial agent in solid solution with a dissolution agent. The formulation is administered into a patient's oral cavity, delivering the pharmaceutical agent by absorption through a patient's oral mucosal tissue. The formulation and method provide for improved oral mucosal delivery of the pharmaceutical agent.
Patent CA-2389335-A1 (CA)
Inventor: YEUNG FAN
IPC: C12N15/09
Filed: 2000-10-26
Abstract: The present invention provides methods and compositions for the delivery and expression of therapeutic genes for treating prostate and non-prostate tumors in a gene therapy setting with therapeutic genes driven by a super PSA  promoter. This approach enhances the capability of increasing the size of therapeutic gene inserts and maintaining specificity and efficiency of genes expression. This form of gene therapy strategy can be applied either alone or in combination with other adjuvant therapies or used in combination with various gene therapy strategies to achieve the maximum effect in cancer treatment, and in normal and benign tissues to enhance therapeutic gains.
Patent CA-2390799-A1 (CA)
Title: Fluid level verification apparatus
Inventor: WECH MICHAEL J
IPC: G01F23/02
Filed: 2002-06-17
Abstract: An improved fluid level verification apparatus which may be manufactured or otherwise fabricated as a kit and assembled at a remote location for use on liquid filled containers and configured to reduce inherent mechanical stresses on the inspection tube and resists leakage due to environmental, chemical, thermal or mechanical expansion cycles by using internal grooves and entrapped o-rings.
Patent CA-2390985-A1 (CA)
Title: Bale processor
Inventor: LEPAGE CHARLES
IPC: A01F29/00
Filed: 2002-06-19
Abstract: Disclosed is an apparatus for disintegrating bales of agricultural material such as hay. The apparatus has a chassis with a bale receptacle mounted thereon. A disintegrator is mounted in the bale receptacle and is adapted to disintegrate baled crop material in the bale receptacle and discharge the processed baled material out of the bale receptacle. A manipulator is mounted in the processing tub above the disintegrator adapted to manipulate the baled crop material in the bale receptacle to expose different parts thereof to the disintegrator and a passive support means is provided in the bale receptacle above the disintegrator. The manipulator and passive support means are positioned on opposing sides of the disintegrator to facilitate maintenance of the baled crop material above the disintegrator such that the disintegrator engages the baled crop material between the manipulator and the passive support means.
Patent CA-2391410-A1 (CA)
Inventor: LIEBERT ALEXANDER
IPC: H04N7/16
Filed: 2000-12-04
Abstract: Apparatus and methods for providing enhanced consumer access to information sources and controllable entities. An Access device can be a stand alone device such as a DVD player in which the DVD disk contains the back-end information network. Other Access devices obtain the back-end information network from remote sources. By way of a specific example, the consumer can then view a game and interactively select every television camera located at the game venue.
Patent CA-2391791-A1 (CA)
Inventor: DE ROTHSCHILD BENJAMIN
IPC: A61K9/64
Filed: 2001-05-18
Abstract: The invention concerns a pharmaceutical composition containing cocaethylene as active ingredient and its use for treating psychoactive substance dependence, in particular cocaine.
Patent CA-2393526-A1 (CA)
Inventor: GUAN HOLLY
IPC: A61K47/48
Filed: 2000-12-07
Abstract: The present invention is directed to a composition and pharmaceutical preparations for introducing nucleic acids including oligo- or poly-nucleoti de into cells in a host tissue by a delivery system and a method of preparing such a composition. The composition for delivery of nucleic acids comprises polymeric carrier particles that are essentially free of groups having a positive electric charge and the nucleic acids are provided essentially on t he surface of the particles. The carrier particle is insoluble in water but suitably it is able to absorb water quickly.
Patent CA-2394277-A1 (CA)
Title: Dishwasher with adjustable rack
Inventor: SHELLABARGER TIFFANY H
IPC: A47L15/50
Filed: 2002-07-19
Abstract: A dishwasher is provided with an adjustable rack that can be moved upwardly and downwardly within the washing chamber to accommodate different sized objects to be washed. The lift mechanism for the rack is housed within the sidewalls of the dishwasher. The lift mechanism employs a cable system to raise both sides of the rack simultaneously, with the rack positioned within or outside the washing chamber and with the rack either loaded or unloaded. In one embodiment, the lift mechanism is manually actuated by turning a handle. In another embodiment, the lift mechanism includes an electric motor with a switch on the control panel for raising and lowering the rack.
Patent CA-2395194-A1 (CA)
Inventor: MORLEY STEVEN A
IPC: G06F12/14
Filed: 2000-11-28
Abstract: La présente invention concerne un appareil et un procédé de codage et de stockage de signaux qui représentent au moins des informations stockées sur un support de stockage (100). Un générateur (108) source est configuré de façon à convertir ces signaux en informations d'image numérisée. Un compresseur (112) est configuré de façon à recevoir ces informations d'image numérisée en provenance du générateur (108) source et à compresser cette image numérisée. Une machine à chiffrer (112) est configurée de façon à recevoir ces informations d'image numérisée compressée en provenance du compresseur (112) et à chiffrer ces informations d'image numérisée compressée. Un dispositif (116) de stockage est configuré de façon à stocker ensuite ces informations d'image numérisée compressée sur le support de stockage.
Patent CA-2395504-A1 (CA)
Inventor: CHARTRAND JOHN HENRY
IPC: G09B15/00
Filed: 2002-08-13
Abstract: Magnetic Music Notes is a variety of music notation shapes including notes, their corresponding rests and music symbols that are made of magnetic material or made with magnetic material or properties attached allowing the notes, rests and music symbols to adhere to a blackboard or any other surface that contains metallic or magnetic properties. It is used as a music teaching manipulative to help teach music students how to read and write music notation. The main components consist of magnetic material in the shapes of various music notes, rests and other music symbols related to music notation. They comprise of whole, half, quarter, eighth and sixteenth notes and their corresponding rests, other notes including triplets, double notes and dotted notes, symbols including flats, sharps and natural signs, treble and bass clefs, bar lines, end bar lines, repeat bar lines, letters of the alphabet from A to G and numbers including 0,1,2,3,4,6 and 8.
Patent CA-2396564-A1 (CA)
Title: Traitement de signal de couleur
Inventor: HORDLEY STEPHEN
IPC: G06V10/56
Filed: 2001-01-12
Abstract: L'invention concerne un procédé de réglage des N composantes d'un signal de couleur à N composantes (telles que les 3 composantes d'un signal de couleur RVB) par rapport à la température de couleur d'une lumière d'éclairage pendant l'imagerie d'un sujet coloré. Ce procédé consiste à calculer la différence entre chacune des composantes du signal de couleur pour des températures différentes de la lumière d'éclairage, et à utiliser un algorithme fondé sur la densité spectrale de l'unité d'imagerie ainsi qu'une équation de Planck définissant l'éclairage du corps noir afin d'obtenir les N composantes dont les valeurs sont indépendantes de la température de couleur de la lumière d'éclairage. La normalisation des valeurs ajustées rend ces valeurs indépendantes de l'intensité d'éclairage et permet de réduire la durée de traitement en vue d'un traitement supplémentaire des signaux. L'invention concerne également un système de compensation de correction de gamma fréquemment intégré dans des caméras.
Patent CA-2399463-A1 (CA)
Title: Combination drug
Inventor: ODAKA HIROYUKI
IPC: C07D417/06
Filed: 2001-02-08
Abstract: A TNF-.alpha. inhibitor comprising a combination of an insulin resistance- ameliorating agent with an HMG-CoA reductase inhibitor which is useful as a preventive or a remedy for inflammatory diseases, etc.
Patent CA-2401640-A1 (CA)
Inventor: SAWYER JAYMIE ROBIN
IPC: G01N33/543
Filed: 2001-02-01
Abstract: The present invention provides an apparatus and methods for the electrical detection of bacterial cells. Specifically, the present invention provides an apparatus and methods for the electrical detection of viable bacteria. The present invention further provides an apparatus and methods for differentiating between multiple bacterial cell types using electrical detection techniques.
Patent CA-2402097-A1 (CA)
Title: Mounting assembly for straw chopper blades
Inventor: BUEERMANN MARTIN
IPC: A01F12/40
Filed: 2002-09-10
Abstract: A mounting assembly for fastening blades to a straw chopper rotor. The rotor is provided with a plurality of mounts each mount having a rotor mounting hole.  The blades are secured to the mounts. Each blade is provide with a blade mounting hole. A pin is inserted into the rotor mounting hole and the blade mounting hole.  The pin is provided with a locking element for holding the pin in place. The locking element having a trapping position where it is locked in place and a loosening position wherein the pin can be removed. The locking element is held in its trapping position by a spring. The locking element engaging a recess having an edge for holding the locking element in the trapping position.
Patent CA-2402441-A1 (CA)
Inventor: SAARINEN KARI
IPC: G01M15/12
Filed: 2001-03-19
Abstract: The present invention relates to a method of determining speed of rotation of a motor. The method involves collecting samples with a measuring sensor at a sampling frequency, set on the basis of mechanical vibration of the motor, for the duration of a measurement period and storing the samples in the memory of a data carrier as measurement data of a fixed format. The speed of rotation of the motor is determined from the measurement data by determining the cycle length of a periodic vibration signal in the time domain by means of a maximum likelihood estimate calculated by maximizing a maximum likelihood function adjusted to the measurement data, the speed of rotation being obtained from the frequency point where the maximum likelihood function obtains its maximum value.
Patent CA-2405117-A1 (CA)
Title: Specific inhibitors of ribosome recycling factor (rrf)
Inventor: KAJI HIDEKO
IPC: A61P31/04
Filed: 2001-04-02
Abstract: Oligoguanylic acid inhibits the activity of Ribosome Recycling Factor (RRF), a soluble factor responsible for disassembly of the post-termination complex.  RRF is essential for all bacteria because it is required for the recycling of spent ribosomes to initiate the translation of another mRNA into another polypeptide. As eukaryotic cytoplasmic protein synthesis does not require RRF, inhibitors of RRF will be efficacious as an anti-bacterial agent. The present invention provides oligoguanylic acid, sd-G4, or derivatives thereof, in particular, to serve as a lead compound for the development of novel anti-bacterial therapeutic agents.
Patent CA-2405230-A1 (CA)
Title: Bone screw
Inventor: REYNDERS PIET
IPC: A61B17/74
Filed: 1999-09-08
Abstract: The bone screw has a head (1), a shank (2), a central longitudinal axis (3), a screw tip (4), a jacket surface (5), an external thread (6), and a total length (L), with a bore (7) being provided which is coaxial with the longitudinal axis (3) and open towards the head (1) and which is connected to the jacket surface (5) via at least one channel (8) extending transversely to the longitudinal axis (3) and opens towards the outside in the form of at least one perforation (9) through the jacket surface (5). The bore (7) is closed towards the screw tip (4).     The bone screw has the advantage that bone cement can be introduced into the surrounding bone in such a way that an artificial, coaxial bed of cement forms for the thread of the bone screw, which bed of cement, however, adjoins the screw only along the sides, with the result that the screw can be screwed further forwards in the axial direction even after the cement has hardened.
Patent CA-2405285-A1 (CA)
Inventor: VAN DEN BRINK PETER JOHN
IPC: B01J27/185
Filed: 2001-04-06
Abstract: L'invention concerne un nouveau procédé de production d'hydrocarbures qui consiste à mettre un mélange de monoxyde de carbone et d'hydrogène à une température et à une pression élevées en contact avec un catalyseur contenant un métal du groupe VIII disposé sur un support. Ce métal du groupe VIII est présent au moins partiellement sous forme métallique et le catalyseur contient en outre du phosphate inorganique à raison d'au moins 0,05 % en poids, calculé comme phosphore élémentaire par rapport au poids du catalyseur. L'invention concerne également un nouveau catalyseur comprenant, disposé sur un support, un métal du groupe VIII choisi dans le groupe constitué de nickel, cobalt, fer et ruthénium, et un autre métal choisi dans le groupe constitué de manganèse, vanadium, zirconium et rhénium, lequel catalyseur contient en outre du phosphate inorganique à raison d'au moins 0,05 % en poids, calculé comme phosphore élémentaire par au poids du catalyseur. L'invention concerne enfin un procédé de préparation de la composition de ce nouveau catalyseur.
Patent CA-2407487-A1 (CA)
Title: Transit planning system
Inventor: STROPE GARETH R
IPC: G08G1/123
Filed: 2001-03-19
Abstract: An off-line transit planning and management system is disclosed. The off-lin e transit planning and management system is to be integrated into an on-line transit and management planning system. The process disclosed includes loggi ng timepoints and generating route, pattern, block, and schedule information therefrom to be suplied to a database that is connected to a real-time trans it management system.
Patent CA-2407847-A1 (CA)
Inventor: FRASER PAUL E
IPC: C12N15/09
Filed: 2001-06-19
Abstract: The present invention provides a transgenic animal model of Alzheimer's Disease designated TgCRND8 as well as a method for making such model, which allows for the characterization of the etiology of the disease as well as for providing a system for the development and testing of potential treatments.
Patent CA-2408033-A1 (CA)
Title: Pharmaceutical composition comprising a free-radical scavenging sedative agent and a metal ion chelating agent
Inventor: GOODALE DAVID BUELL
IPC: A61P13/12
Filed: 2001-05-22
Abstract: The invention relates to a method of treating, and improving survival in, critically ill patients, and the use of certain sterile sedative pharmaceutical compositions for the manufacture of a medicament for improving the survival of such patients; in particular such use of pharmaceutical compositions comprising a free radical scavenging sedative agent (such as propofol) and a metal ion chelating agent (such as edetate) in association with a pharmaceutically-acceptable diluent or carrier, especially such composition comprising an oil-in- water emulsion in which propofol dissolved in a water-immiscible solvent, is emulsified with water and stabilised by means of a surfactant, and which further comprises a metal ion chelating agent (such as disodium edetate).
Patent CA-2410401-A1 (CA)
Title: A novel treatment for cough
Inventor: PIOMELLI DANIELE
IPC: A61K31/121
Filed: 2001-05-23
Abstract: The invention discloses the existence of cannabinoid receptors in the airways, which are functionally linked to inhibition of cough. Locally acting cannabinoid agents can be administered to the airways of a subject to ameliorate cough, without causing the psychoactive effects characteristic of systemically administered cannabinoids. In addition, locally or systemically administered cannabinoid inactivation inhibitors can also be used to ameliorate cough. The present invention also defines conditions under which cannabinoid agents can be administered to produce anti-tussive effects devoid of bronchial constriction.