baber/WOPTO huggingface dataset:
Patent CA-3124828-A1 (CA)
Title: Levelling spacer device for slabs
Inventor: SIGHINOLFI RICCARDO
IPC: E04F21/22
Filed: 2021-07-15
Abstract: A levelling spacer device (10) for laying slab-shaped products (P) comprising: -    at least one base (20) having a lower surface (21) and an opposite upper surface (22) defining a support plane for at least two tiles (P) placed side by side, which is placed at a first distance (d1) from the lower surface (21); -    a spacer bridge (30) provided with: o    two legs (31) placed side by side between each other along a flank-ing direction and each one rising from a portion of the upper surface (22) of the base (20), wherein each leg (31) is frangibly connected to the respective base portion by a predefined fracture line (310) placed at a second distance (d2) from the lower surface (21) greater than the first distance (d1), wherein the fracture line (310) is formed by a longitudinal cut that is parallel to the flanking direction; and o    a crosspiece (32), which joins the top of the two legs (31); and a through opening (40) adapted to be crossed by a pressure wedge (50) along a crossing direction (C) orthogonal to the flanking direction, wherein the through opening (40) is peripherally delimited at the top by the crosspiece (32) of the bridge (30), laterally by the legs (31) of the bridge (30) and at the bottom by a central portion (220) of the upper surface (22) of the base (20) coplanar with the support plane.
Patent CA-3125628-A1 (CA)
Inventor: KRALIS KONSTANTINE P
IPC: F16P3/00
Filed: 2020-01-14
Abstract: A hydraulic press is disclosed for the extraction of rosin from plants, including a lower platen with a built-in gutter rail collection system. The upper platten is driven by two parallel hydraulic rams linked by a common support rod to ensure uniform pressure distribution on plant parts to be pressed. A computerised system is provided for controlling and monitoring the press remotely through a wireless device. Safety features have been included to prevent injury of the operator or damage to the product, namely ultrasonic sensors forming an ultrasonic field around the pressing area, so that the rosin press is automatically switched off when the operator's hands inadvertently enter the pressing area, a temperature sensor attached to a platen or a breaker fuse to interrupt heat supply to the platen, and a pressure sensor which causes the press to automatically shut down in case of overload.
Patent CA-3128460-A1 (CA)
Title: Coffee grinding machine with improved dosing system and associated method
Inventor: DIONISIO ANDREA
IPC: A47J42/40
Filed: 2020-02-05
Abstract: A coffee grinding machine is described, said machine comprising a first grinder and a second grinder cooperating with each other based on a first grinding parameter for grinding coffee beans, thus obtaining a first dose of ground coffee during a first grinding cycle, wherein the coffee grinding machine also comprises a weighing device configured to measure the weight of said first dose of coffee substantially at the end of said first grinding cycle, wherein said weight measurement of said first dose measured at the end of said first grinding cycle is used to set a second grinding parameter of a second dose, ground after the first dose during a second grinding cycle. The coffee grinding machine is configured to interrupt the grinding of said second dose during said second grinding cycle in a manner not dependent on an actual weight measurement of said second dose.
Patent CA-3131154-A1 (CA)
Inventor: WILSON DAVID L
IPC: G06T7/11
Filed: 2020-02-20
Abstract: A first set of embodiments relates to an apparatus comprising one or more processors configured to: access three-dimensional (3D) ultrasound imaging of an eye; generate at least one segmented ocular structure by segmenting at least one ocular structure represented in the 3D ultrasound imaging using at least one deep learning ocular structure segmentation model configured to generate a predicted segmentation volume of the at least one ocular structure based on at least one portion of the 3D ultrasound imaging; compute at least one clinical metric associated with the at least one segmented ocular structure based on the at least one segmented ocular structure; and display at least one of: the at least one segmented ocular structure, the at least one clinical metric, the 3D ultrasound imaging, or at least one portion of the 3D ultrasound imaging.
Patent CA-3132293-A1 (CA)
Inventor: HEANEY JOHN S
IPC: G05D7/06
Filed: 2020-02-18
Abstract: A programmable, electronically controlled sprinkler system (10) has hermetically sealed internal chambers (102) which enclose all of the internal water flow, valves (200), mechanical and rotational components (300) and a plurality of magnetic coupling arrangements (204,304) which allow external motors (202,302) to control operation of the internal mechanical components without requiring any hydraulic seals.
Patent CA-3134258-A1 (CA)
Inventor: DALY CHRISTOPHER
IPC: A61P35/00
Filed: 2020-04-09
Abstract: The present invention provides fully human antibodies that bind to the RET receptor tyrosine kinase, compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for treating diseases, disorders, or conditions associated with expression, activation, or signaling of the RET receptor tyrosine kinase gene, or a rearranged form thereof, including cancerous conditions and the pain associated with the cancer, or for alleviating the pain associated with other conditions attributed to, at least in part, by expression, activation or signaling of RET. The antibodies specific for RET may be useful for slowing tumor cell growth or tumor cell proliferation and also for alleviating the pain associated with the cancer and other conditions. The antibodies may also be useful for diagnosis of a disease, disorder or condition associated with RET activation or signaling.
Patent CA-3139585-A1 (CA)
Inventor: GUNZEL EDWARD
IPC: A61L27/34
Filed: 2020-05-30
Abstract: A biocompatible mernbrane cornposite that can provide an environment that is able to rnitigate or tailor the foreign body response is provided. The rnernbrane composite contains a mitigation layer and a vascularization layer. A reinforcing component may optionally be included to provide support to and prevent distortion of the biocompatible membrane composite <i>in vivo</i>. The mitigation layer may be bonded (<i>e.g.</i>, point bonded or welded) or adhered (intimately or discretely) to an implantable device and/or cell systern. The biocompatible rnembrane composite rnay be used as a surface layer for implantable devices or cell systerns that require vascularization for function but need protection from the host's irnrnune response, such as the formation of foreign body giant cells.  The biocompatible rnernbrane cornposite rnay partially or fully cover the exterior of an irnplantable device or cell system. The rnitigation layer is positioned between the irnplantable device or bioactive scaffold and the vascularization layer.
Patent CA-3140873-A1 (CA)
Title: Cyano cyclobutyl compounds for cbl-b inhibition and uses thereof
Inventor: SANDS ARTHUR
IPC: C07D471/04
Filed: 2020-05-15
Abstract: Compounds, compositions, and methods for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway are disclosed. The compounds, compositions, and methods can be used to modulate the immune system, to treat diseases amenable to immune system modulation, and for treatment of cells in vivo, in vitro, or ex vivo. Also disclosed are pharmaceutical compositions comprising a Cbl-b inhibitor and a cancer vaccine, as well as methods for treating cancer using a Cbl-b inhibitor and a cancer vaccine; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods for treating cancer using a Cbl-b inhibitor and an oncolytic virus.
Patent CA-3141356-A1 (CA)
Title: Pan-cancer transcriptional signature
Inventor: AWADALLA PHILIP
IPC: G16B25/10
Filed: 2020-05-20
Abstract: There is described herein a pan-cancer transcriptional signature. In one aspect, there is described a method of diagnosing cancerous cells in a patient, the method comprising: a) providing a sample containing genetic material from patient cells suspected of being cancerous; b) determining or measuring expression levels in the patient cells of at least 3 of the 1919 genes listed in Table B; c) computing a score using a classifier that takes said expression level values as input, the classifier having been previously trained on known cancerous and non-cancerous samples; wherein the score provides a likelihood of a cancerous cell.
Patent CA-3141539-A1 (CA)
Inventor: AESCHLIMANN MARCEL
IPC: A61N7/00
Filed: 2020-03-25
Abstract: L'invention se rapporte au domaine de la stimulation cellulaire par énergie mécanique, en particulier par énergie acoustique, par exemple de la stimulation par ultrasons, tels que des ultrasons focalisés (FUS). L'invention concerne un procédé de détermination d'un ensemble de paramètres de traitement spécifique à un sujet permettant une stimulation d'onde acoustique et un procédé de validation d'un ensemble de paramètres de traitement permettant une stimulation d'onde acoustique. Le procédé de détermination d'un ensemble de paramètres de traitement spécifique à un sujet comprend les étapes consistant à générer des données spécifiques à un sujet, l'étape consistant à générer les données spécifiques à un sujet comprenant la mesure d'une propriété géométrique d'une partie corporelle, et la détermination d'une distribution de champ cible dans la partie corporelle. Le procédé comprend en outre l'étape consistant à sélectionner un ensemble de paramètres de traitement entre au moins deux ensembles différents de paramètres de traitement, la sélection étant effectuée avant une étape d'application d'un ensemble quelconque de paramètres de traitement à la partie corporelle. Le procédé de validation d'un ensemble de paramètres de traitement permettant une stimulation d'onde acoustique comprend les étapes consistant à déterminer une distribution de champ cible d'un champ acoustique dans une partie corporelle, à recevoir un ensemble associé de paramètres de traitement d'au moins un transducteur, à générer un modèle 3D spécifique au sujet de la partie corporelle, et à déterminer une différence entre la distribution de champ cible et une distribution de champ déterminée dans le modèle 3D spécifique au sujet.
Patent CA-3142848-A1 (CA)
Inventor: LYLE ZACHARY J
IPC: A01D43/10
Filed: 2021-12-17
Abstract: A harvesting apparatus includes a crop conditioning element coupled to a frame, and a hood moveable relative to the crop conditioning element. An actuating system moveably connects the hood to the frame. The actuating system includes a driven lever arm rotatably attached to the frame and including a first lever connection and a second lever connection positioned opposite each other across a lever rotation axis. A first pivot assembly is rotatably attached to the frame and includes a first pivot connection coupled to the first lever connection of the driven lever arm, and a second pivot connection coupled to a first lift location of the hood. A second pivot assembly is rotatably attached to the frame and includes a third pivot connection coupled to the second lever connection of the driven lever arm, and a fourth pivot connection coupled to a second lift location of the hood.
Patent CA-3143169-A1 (CA)
Inventor: PARKS GEORGE
IPC: A61P43/00
Filed: 2020-06-10
Abstract: L'invention concerne des procédés de purification d'un anticorps anti-a4ß7 humanisé, tel que le vedolizumab, produit dans une culture de cellules de mammifère, ainsi que des compositions résultant desdits procédés de purification.
Patent CA-3147850-A1 (CA)
Title: Proteine l1 de papillomavirus chimerique
Inventor: LUO CHUNXIA
IPC: C12N15/37
Filed: 2020-07-17
Abstract: La présente invention concerne une protéine L1 de papillomavirus chimérique et un polynucléotide codant pour celle-ci, ainsi que des particules de type viral de HPV et un procédé de préparation associé. La protéine L1 de papillomavirus chimérique comprend un fragment N-terminal dérivé de la protéine L1 de papillomavirus du premier type, le fragment N-terminal conservant l'immunogénicité de la protéine L1 correspondant à des types de HPV ; et un fragment C-terminal dérivé de la protéine L1 de papillomavirus d'un second type et ayant de meilleures caractéristiques de quantité d'expression et de solubilité que celles d'autres types de protéine L1, la protéine L1 de papillomavirus chimérique ayant l'immunogénicité de la protéine L1 correspondant à des types de HPV. La protéine L de papillomavirus chimérique a une quantité d'expression plus élevée et une meilleure solubilité et peut être utilisée pour la production à grande échelle de vaccins.
Patent CA-3150029-A1 (CA)
Inventor: BENSMANN STEFAN
IPC: F16P3/12
Filed: 2020-08-07
Abstract: The invention relates to a kneading machine (1) for food doughs, comprising a kneading machine frame (2) with a lower part (4) and a head section (3), which can be moved in respect of the lower part (4) between a lower operating position and an upper cleaning position, wherein: a kneading bowl (8) is arranged on the lower part (4) and a drivable kneading tool (5) and a lid (7) closing an opening in the kneading bowl (8) in the operating position are arranged on the head section (3); the lid (7) is enclosed around the periphery by a first safety ring (18) of a safety device (15), which ring projects beyond the lid (7) on the underside thereof and is mounted movably on the lid (7); the safety device (15) comprises a detection device, which detects a relative movement between the lid (7) and the first safety ring (18); the kneading machine frame (2) has at least two journal bearings (14), each formed of a journal (12) and a matching seat (12); and one of the bearing elements (12) is formed on the lower part (4) and the other bearing element (13) is formed on the head section (3) in such a manner that they engage in one another in the lower operating position and secure the position of the head section (3) relative to the lower part (4). The first safety ring (18) is designed as a single piece with an anti-trap mechanism for the at least two journal bearings (14).
Patent CA-3151248-A1 (CA)
Title: Filtration sur membrane a nanopore asymetrique (anm) basee sur la taille pour l'isolement, la concentration, et le fractionnement d'exosomes a haut rendement
Inventor: WANG CEMING
IPC: B01L3/00
Filed: 2020-09-15
Abstract: Une technologie de filtration sur membrane à nanopore asymétrique (ANM) basée sur la taille pour l'isolement, la concentration, et le fractionnement d'exosomes à haut rendement. La conception ANM empêche la déformation, la lyse, et la fusion d'exosomes en raison de la forte force externe et augmente ainsi de manière significative le rendement (jusqu'à 92 %) tout en conservant d'autres avantages de l'ultrafiltration basée sur la taille. Elle offre également une caractéristique unique de pouvoir éliminer les protéines contaminantes des exosomes. Elle offre un débit supérieur, un rendement, une pureté d'échantillon, un facteur de concentration, et un fractionnement de taille plus précis que les approches actuelles.
Patent CA-3152384-A1 (CA)
Title: Methode de traitement d'un trouble respiratoire du sommeil
Inventor: COOKE IAN
IPC: A61K31/196
Filed: 2019-09-06
Abstract: La présente invention concerne des méthodes de traitement ou de prévention d'un trouble respiratoire du sommeil. Plus spécifiquement, l'invention concerne une méthode de traitement ou de prévention de l'apnée du sommeil comprenant l'utilisation d'un dispositif d'ouverture de canal potassium KCNQ.
Patent CA-3155804-A1 (CA)
Title: Systems and methods for analyzing casing bonding in a well using radial sensing
Inventor: STEEL GEOFF
IPC: E21B47/14
Filed: 2020-10-26
Abstract: Implementations described and claimed herein provide systems and methods for isolation detection. In one implementation, recorded data is obtained. The recorded data includes radial acoustic waves transmitted and received using a radial sensor of an acoustic logging tool deployed in a wellbore. Clockwise waves are separated from counterclockwise waves by converting the recorded data from a time domain to a frequency domain. The clockwise waves are shifted into shifted clockwise waves, and the counterclockwise waves are shifted into a shifted counterclockwise waves. A forward wave is generated by combining the shifted clockwise waves, and a reflected wave is generated by combining the shifted counterclockwise waves. One or more isolation regions are identified in the wellbore using the forward wave and the reflected wave.
Patent CA-3155984-A1 (CA)
Inventor: ZHANG MINGMING
IPC: C07D471/04
Filed: 2021-01-05
Abstract: L'invention concerne un dérivé de biphényle fluor à double liaison ayant une structure telle que représentée par la formule (I), son procédé de préparation et son utilisation pharmaceutique. Le dérivé de biphényle fluor à double liaison ayant une structure telle que représentée par la formule (I) peut être largement utilisé dans la préparation de médicaments pour la prévention et/ou le traitement de cancers ou de tumeurs, de maladies et troubles liés à l'immunité, de maladies transmissibles, de maladies infectieuses ou de maladies métaboliques à médiation par des voies de signalisation PD-1/PD-L1, et est censé être développé dans une nouvelle génération d'inhibiteurs PD-1/PD-L1.
Patent CA-3160402-A1 (CA)
Inventor: CHANDUSZKO ANDRZEJ
IPC: A61B17/3207
Filed: 2014-12-30
Abstract: The present disclosure is generally directed to novel bead geometries that can provide improved sanding efficiencies in rotational atherectomy procedures. The abrasive elements disclosed herein may open stenotic lesions to diameters that are substantially larger than the maximum diameter of the abrasive element. In some embodiments, the abrasive elements may open stenotic lesions to diameters that are substantially larger than the maximum diameter of the sheath from which the abrasive element is delivered through. In some embodiments the abrasive elements are configured to expand when the abrasive elements are rotated at high speeds. In some embodiments, the abrasive elements have local centers of mass that are positioned at opposite diagonal ends. Accordingly, the abrasive elements disclosed herein may have improved sanding ranges, reduce treatment times, and prevent restenosis.
Patent CA-3162911-A1 (CA)
Inventor: PARKER ANDREW SCOTT
IPC: A61B5/00
Filed: 2020-12-07
Abstract: Est décrit, une mise en prise à états multiples dotée de systèmes de surveillance continue du glucose (CGM). Compte tenu du nombre de personnes qui portent des systèmes de CGM et parce que les systèmes de CGM produisent des mesures en continu, une plateforme qui fournit un système de CGM peut avoir une quantité énorme de données. Cette quantité de données est pratiquement, pour ne pas dire réellement, impossible à traiter pour les êtres humains. Selon des modes de réalisation, une plateforme de CGM comprend une plateforme d'analyse de données qui obtient des paquets de mesures de glucose fournies par un système de CGM et obtient également des données supplémentaires associées à un utilisateur. La plateforme d'analyse de données génère des informations d'état pour l'utilisateur en traitant ces paquets CGM et les données supplémentaires, au moins en partie, à l'aide d'un ou de plusieurs modèles. Sur la base de ces informations d'état, la plateforme d'analyse de données commande la communication avec l'utilisateur, laquelle peut consister à générer des stratégies d'intervention destinées à empêcher les utilisateurs de passer à un état négatif tel que l'utilisation discontinue du système CGM.
Patent CA-3163043-A1 (CA)
Title: Systems and methods relating to customer experience automation
Inventor: SEKAR ARCHANA
IPC: G06Q10/00
Filed: 2020-12-29
Abstract: A computer-implemented method for automating actions for a customer in relation to an interaction between the customer and an agent of a contact center, the interaction including an exchange of statements made by the customer and agent. The method includes the steps of: receiving a transcript of the interaction; via a first analysis, analyzing the transcript; from results of the first analysis, identifying: a pending action, wherein the pending action is an action promised by the customer or agent that will be resolved after the interaction; and a target timeframe for resolving the pending action; given the pending action, determining a follow-up workflow that includes one or more follow-up actions, each of the one or more follow-up actions comprising an action intended to assist the customer to resolve the pending action; and automatically executing the one or more follow-up actions.
Patent CA-3163266-A1 (CA)
Title: Nouveau polypeptide mutant a activite attenuee de citrate synthase et procede de production de l-acide amine l'utilisant
Inventor: AHN CHAN HONG
IPC: C12P13/06
Filed: 2020-08-04
Abstract: La présente invention concerne un nouveau polypeptide mutant présentant une activité atténuée de citrate synthase, un micro-organisme produisant de la leucine comprenant le polypeptide mutant, et un procédé de production de L-acide aminé utilisant le micro-organisme.
Patent CA-3164547-A1 (CA)
Inventor: NGUYEN MINH
IPC: A61F2/07
Filed: 2020-02-07
Abstract: Bifurcated endoprosthetic devices, systems and methods are disclosed herein for treating disease of human vasculature. In various embodiments, a bifurcated endoprosthesis includes a trunk portion and a plurality of legs, where the legs are constrained such that they maintain alignment with one another. In some examples, the legs and bifurcation of an endoprosthetic device may be formed by cutting a tubular graft component along a portion of less than its entire circumference in a longitudinally central region, and then folding the tubular graft component along the uncut portion to define two legs, where the uncut portion defines the bifurcation. In some such examples, the folded tubular graft component can be coupled with a tubular trunk component to form the bifurcated endoprosthetic device.
Patent CA-3166974-A1 (CA)
Title: Appareil pour la generation d'un aerosol
Inventor: AOUN WALID ABI
IPC: A24F40/30
Filed: 2021-02-09
Abstract: L'invention concerne un appareil (100) pour générer un aérosol destiné à être inhalé par un utilisateur. L'appareil (100) comprend un premier contenant (110) destiné à contenir un liquide à partir duquel, lors de l'utilisation, l'appareil (100) génère un flux d'aérosol ; un second contenant destiné à contenir un matériau (108) dans lequel, lors de l'utilisation, le flux d'aérosol passe ; un agencement de génération d'aérosol (112) destiné à générer le flux d'aérosol à partir du liquide contenu dans le premier contenant ; et un agencement de chauffage (118) destiné à chauffer le matériau (108) contenu dans le second contenant. L'agencement de chauffage (118) est conçu pour chauffer le matériau (108) contenu dans le second contenant à une température qui empêche ou réduit la condensation provenant du flux d'aérosol se formant sur le matériau et qui est inférieure à une température requise pour provoquer une formation d'aérosol substantielle à partir du matériau. Un procédé d'utilisation d'un tel appareil (100) est également divulgué.