Patent SG-11201909867W-A (SG)
Title: Materials and methods for protecting against neuromas
Inventor: DEISTER CURT
IPC: A61L31/00
Filed: 2018-04-25
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT o iimion ono oIIIDIDIIIII11010111Dl o ifloio (10) International Publication Number WO 2018/200638 A4 (51) International Patent Classification: A61B 90/00 (2016.01) A61L 31/00 (2006.01) A61L 31/04 (2006.01) A61N 1/05 (2006.01) (21) International Application Number: PCT/US2018/029305 (22) International Filing Date: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with amended claims (Art. 190)) with information concerning one or more priority claims considered void (Rule 26bis.2(d)) Date of publication of the amended claims: 06 December 2018 (06.12.2018) 25 April 2018 (25.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 15/496,578 25 April 2017 (25.04.2017) US (63) Related by continuation (CON) or continuation-in-part (CIP) to earlier applications: US 14/036,405 (CIP) Filed on 25 September 2013 (25.09.2013) US 61/705,251 (CIP) Filed on 25 September 2012 (25.09.2012) (71) Applicant: AXOGEN CORPORATION [US/US]; 13631 Progress Boulevard, Suite 400, Alachua, FL 32615 (US). (72) Inventors: DEISTER, Curt; c/o Axogen Corporation, 13631 Progress Boulevard, Suite 400, Alachua, FL 32615 (US). SIMON, Crystal; c/o Axogen Corporation, 13631 Progress Boulevard, Suite 400, Alachua, FL 32615 (US). FALERIS, Jennifer; c/o Axogen Corporation, 13631 Progress Boulevard, Suite 400, Alachua, FL 32615 (US). (74) Agent: SARGEANT, Heath M. et al.; Holland & Knight LLP, 10 St. James Avenue, Boston, MA 02116 (US). = (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, W O 20 18/ 200638 A4 (54) Title: MATERIALS AND METHODS FOR PROTECTING AGAINST NEUROMAS (57) : The subject invention provides devices and methods for alleviating discomfort associated with neuroma formation. The devices 36 and methods of the invention effectively use the body's natural response of reconstructing implanted biomaterials to minimize the size of, iso- late, and protect a neuroma. In preferred embodiments, the subject de- vice is a cylindrical cap, wherein the internal chamber of the cylindrical cap physically partitions the nerve to enable an arrangement of nerve fibers (as opposed to haphazardly arranged nerve fibers often produced in neuromas). Tabs arranged on the outside of the cap can be used to manipulate the cap into place on a nerve. The open end can also be con- figured with flaps that can be used to widen the open end for easier in- sertion of the nerve into the cap. In addition, the cap's material remod- els into a tissue cushion after implantation, which protects the neuroma from being stimulated and inducing pain. FIG. 6A