baber/WOPTO huggingface dataset:
Patent SK-287794-B6 (SK)
Title: Lactam compound, process for its preparation, and its use as medicament
Inventor: KOENIG THOMAS MITCHELL
IPC: A61P43/00
Filed: 2001-11-02
Abstract: It is described (N)-((S)-2-hydroxy-3-methyl-butyryl)-1-(L- alaninyl)-(S)-1-amino-3-methyl-2,3,4,5-tetrahydro-1H-3- benzazepin-2-one dihydrate, its use as a medicament for preventing, treating or inhibiting the progressing of Alzheimer's diseases and process for its preparation.
Patent CZ-299018-B6 (CZ)
Title: Quick-dissolving pharmaceutical preparation
Inventor: OHASHI MAMORU
IPC: A61K31/4985
Filed: 1998-10-15
Abstract: In the present invention, there is disclosed a quick-dissolving pharmaceutical preparation exhibiting strong inhibition activity relative to aldose reductase, containing micronized (R)-2-(4-bromo-2-fluorobenzyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-4-spiro-3?-pyrrolidine-1,2?,3,5?-tetrone, having particle size less than 20 microns and having solubility 509 percent by weight or more of the active component after 15 minutes starting from the onset of the dissolving test. The pharmaceutical preparation according to the present invention optionally contains a stabilizer and exhibits significantly improved stability.
Patent CZ-291752-B6 (CZ)
Title: Exhaust gas catalyst and process for producing thereof
Inventor: STOEPLER WALTER
IPC: F01N3/28
Filed: 1998-10-21
Abstract: The present invention relates to a catalyst intended particularly for motor vehicles, said catalyst having a housing (4) consisting of a cylindrical tubular section (2) an inlet funnel (3a) and an outlet funnel (3b), at least one cylindrical monolith (1) arranged inside said tubular section (2) and a slotted space (6) extending between said monolith (1) circumferential surface (15) and said housing (4) inner surface (5) and fixing with a radial prestress a liner (7). Said tubular section (2) has at least one stepwise variable surface of its inner cross section in the form of longitudinal sections (9, 10). Inner surface (5a) of the longitudinal sections (9, 10) extends substantially parallel to the central longitudinal axis (32) of the tubular section. The monolith (1) can consists of monoliths (1a, 1b), the front region of which turned toward the inlet funnel (3a) is encircled by a narrowed longitudinal section (9a, 9b) of the housing (4). The liner (7) is represented by a liner of mineral fibers or a liner of mineral fibers with vermiculite particles introduced therein. A process for producing such catalyst is characterized in that a monolithic packet (17) is pushed into a tubular section (2) with stepwise variable surface of inner cross section in the form of several longitudinal sections (9, 10).
Patent CZ-301124-B6 (CZ)
Title: Corrosion inhibitors and synergistic combinations of inhibitors for protection of light metals in heat-exchange fluids and engine coolants
Inventor: MAES JEAN-PIERRE
IPC: C23F11/18
Filed: 1999-10-11
Abstract: In the present invention, there is disclosed a corrosion protection composition containing: a) 0.1 to 15 percent by weight of one or more inhibitors being selected from the group consisting of some alkylbenzoic acid, i.e. aliphatic monobasic or dibasic acid each containing 5 to 15 carbon atoms or a salt thereof, and b) 0.005 to 5 percent by weight of fluoride and/or fluorocarboxylic acid or salts thereof.
Patent CZ-301498-B6 (CZ)
Title: C-21 modified epothilones
Inventor: HOEFLE GERHARD
IPC: A01N43/78
Filed: 2000-02-17
Abstract: In the present invention, there is disclosed an epothilone derivative of the general formula Ia or Ib, process for its preparation and pharmaceutical composition in which the derivative is comprised. Those compounds exhibit antifungal and cytotoxic properties and are therefore used in the treatment of tumor diseases and growth disorders.
Patent CZ-300370-B6 (CZ)
Title: Method of reducing concentration of NOx and Ni2O in residual gas from production of nitric acid
Inventor: SCHWEFER MEINHARD
IPC: B01J29/072
Filed: 2001-01-09
Abstract: In the present invention, there is disclosed a method of reducing concentration of NOx and Ni2O in residual gas from production of nitric acid wherein the method comprises passing the residual gas leaving the absorption tower, through a two-stage combination before introduction thereof into a residual gas turbine. In the first stage, the NOx content of the gas is reduced and in the second stage, the N2O content is reduced. The NOx/Ni2O ratio, before entry into the second stage, is in the range from 0.001 to 0.5.This gas gas is in the second step brought to a catalyst, which contains one or more zeolites charged with iron.
Patent CZ-296992-B6 (CZ)
Title: Preparation and isolation of 2-substituted-3-pyridylcarboxylic acids, their carboxylic salts and reduction products
Inventor: HALAMA ALES
IPC: C07D401/04
Filed: 2002-10-03
Abstract: In the present invention, there is disclosed a process for preparing reduction products of 2-substituted 3-pyridylcarboxylic acids of the general formula IV, in which R represents an optionally substituted six-membered heterocycle having one or two nitrogen heteroatoms and being attached to a basic skeleton via a carbon or nitrogen atom, by alkaline hydrolysis of a compound of the general formula I, in which R is as indicated above, and which enters the reaction in either pre-purified or raw state, by the action of a hydroxide of the general formula MOH, in which M denotes an alkali metal to yield a carboxylic acid salt of the general formula II, in which R and M are as specified above, by subsequent neutralization of the compound of the general formula II by a solution of an equimolar amount of hydrogen halogenide of the general formula HX, wherein X represents chlorine or bromine, to yield a salt of the general formula MX and a free carboxylic acid of the general formula III, wherein M and R are as defined above, and by reduction of the acid of the general formula III with a complex hydride. The hydrolysis of the compound of the general formula I is carried out using the hydroxide of the general formula MOH, wherein M is as defined above, in an aqueous-alcoholic solution where separation into two liquid layers takes place. When these two layers are separated, the compound of the general formula II crystallizes from the upper alcoholic layer and after optionally recrystallization it is dissolved in an alcohol of the general formula Ri1OH, in which Ri1 represents alkyl containing 1 to 6 carbon atoms, converted to the acid of the general formula III due to the reaction with a halo acid of the general formula HX, wherein X is as defined above, and subsequently the obtained halide of the general formula MX is filtered off. The reaction mixture is diluted with water and alcohol being present or a portion thereof is distilled off to thereby inducing crystallization. Obtained crystalline product of the general formula III is then reduced by bis-(2-methoxyethoxy)aluminium-sodium dihydrid (SYNHYDRID) of the general formula XI in solutions of a solvent being selected from the group consisting of toluene, benzene, xylene, chlorobenzene, dichlorobenzene, tetrahydrofuran, diethyl ether and arbitrary mixtures thereof to yield a hydroxy derivative of the general formula IV. The obtained product can be preferably used in the preparation of a mirtazapine medicament of the general formula V.
Patent CZ-301290-B6 (CZ)
Title: Process for preparing optically active haloalkanes and alcohols by haloalkane dehalogenase-catylyzed hydrolytic dehalogenation
Inventor: PROKOP ZBYNEK
IPC: C12P5/00
Filed: 2004-12-27
Abstract: In the present invention, there is disclosed a process for preparing optically active haloalkanes and alcohols using hydrolytic dehalogenation of racemic or prochiral halogen hydrocarbons by dehalogenation catalyzed by haloalkane dehalogenases (EC 3.8.1.5) where at least one wild type or modified haloalkane dehalogenase is treated with at least one racemic or prochiral chlorinated, brominated or iodinated compound at the temperature ranging between +10 and +70 degC and pH value ranging between 4.0 and 12.0, in an aqueous system or in a monophasic organic solution or in a monophasic organic/aqueous solution or in organic/aqueous biphasic systems.
Patent SK-286553-B6 (SK)
Title: Rotary locking cylinder for a safety lock, modular system and a key
Inventor: KELLER ERNST
IPC: E05B9/04
Filed: 2001-01-09
Abstract: The rotary locking cylinder comprises a housing (5) and at least one rotor (8) provided with a key channel (27). Tumblers are provided in order to rotationally release the armature (8) with a key (17) associated therewith. A driver (6) is provided with at least one extension element (3) on the active part (2) of the rotary cylinder. Said extension element comprises a housing (24) and a rotatable insert (9). At least one extension element (3) is arranged on an outer side on the active part (2) at a distance from the driver (6). The key shank is extended in a manner which corresponds substantially to the length (A) of the extension element (3). Preferably, the rotatable insert (9) of the extension element (3) is profiled.
Patent SK-285577-B6 (SK)
Title: Corrosion resistant enclosure and methods for its manufacture
Inventor: HEDMAN TOMMY
IPC: B23K20/00
Filed: 1999-04-19
Abstract: In the present invention, there is disclosed a process for producing a corrosion resistant enclosure for radioactive material containers wherein the process is characterized in that a friction tool made of material harder than the material of surfaces to be joined is put between the surfaces of the individual parts of the enclosure made of copper or copper alloy, due to friction of the surfaces to be joined with said friction tool the material of these surfaces plasticized at the point of friction, whereupon said friction tool is removed and the surfaces are friction stir welded by putting them onto each other. The invention further relates to a corrosion resistant enclosure for radioactive material containers consisting of at least two parts of copper or copper alloy, a cavity for an enclosure for radioactive material is arranged, whereby the enclosure is closed within the cavity inside a container by friction stir welding process. Further is also disclosed a method of storing radioactive material.
Patent SK-284467-B6 (SK)
Title: Process for preparing a biocatalyst with a polyvinyl alcohol and a highly mechanically stable biocatalyst with a polyvinyl alcohol produced by this process
Inventor: VORLOP KLAUS-DIETER
IPC: C08J3/075
Filed: 1999-03-30
Abstract: Disclosed is process for preparing a biocatalyst with a biologically active material, in the form of microorganisms, enzymes, spores and/or cells introduced into a gel of polyvinyl alcohol produced by a process having the following steps: (a) use of an aqueous polyvinyl alcohol solution with a degree of hydrolysis >/=98 % by moles, (b) admixture of an additive that is dissolved in the aqueous polyvinyl alcohol solution and forms a separate, finely distributed and aqueous phase after concentration of the solution whereby the additive is selected from the group formed by polyethylene glycol, cellulose esters, cellulose ethers, starch esters, starch ethers, polyalkylene glycol ethers, polyalkylene glycols, long-chain alkanoles (CnH2n+1OH with n 8), sugar esters and sugar ethers, (c) addition of the biologically active material d) drying of the aqueous solution to a residual water content of maximum 50 wt. % to cause the phases to separate and hence the polyvinyl alcohol to gel, (e) rehydrating the polyvinyl alcohol in an aqueous medium.
Patent BR-PI9912208-B8 (BR)
Inventor: THOMAS ALLMENDINGER
IPC: C07C217/08
Filed: 1999-06-23
Abstract: The invention relates to a compound of formula (I),wherein R is an alkyl unsubstituted by one or more polar substituents or an alkenyl unsubstituted or substituted by one or more polar substituents, and X is aryl, or salts thereof. The compounds are effective e.g. against protozoa and trematodes.
Patent EP-1182569-B8 (EP)
Inventor: CHAUVEL GERARD
IPC: G06F12/1081
Filed: 2001-05-11
Granted: 2011-07-06
Abstract: A digital system and method of operation is provided in which several processing resources (340) and processors (350) are connected to a shared translation lookaside buffer (TLB) (300, 310(n)) of a memory management unit (MMU) and thereby access memory and devices. These resources can be instruction processors, coprocessors, DMA devices, etc. Each entry location in the TLB is filled during the normal course of action by a set of translated address entries (308, 309) along with qualifier fields (301, 302, 303) that are incorporated with each entry. Operations can be performed on the TLB that are qualified by the various qualifier fields. A command (360) is sent by an MMU manager to the control circuitry of the TLB (320) during the course of operation. Commands are sent as needed to flush (invalidate), lock or unlock selected entries within the TLB. Each entry in the TLB is accessed (362, 368) and the qualifier field specified by the operation command is evaluated (364). This can be task ID field 302, resource ID field 301, shared indicator 303, or combinations of these. Operation commands can also specify a selected virtual address entry (305). Each TLB entry is modified in response to the command (366) only if its qualifier field(s) match the qualifier(s) specified by the operation command. <IMAGE>   <IMAGE>
Patent EP-1233042-B8 (EP)
Inventor: FREUND BURKHARD DR
IPC: B29C48/03
Filed: 2002-02-08
Granted: 2011-02-02
Abstract: Carbon black with a CTAB surface area from about 10 to 35 m2/g and a DBP absorption from about 40 to 180 ml/100 g, the DELTAD50 value being at least 340 nm. The carbon black may be produced in a furnace-black reactor from a liquid carbon-black raw material and gaseous carbon-black raw material injected into a constriction in the reactor. Compared to other forms of carbon black, the carbon blacks of the present invention have advantageous properties, such as improved dispersibility, and may be economically and conveniently used in rubber mixtures, particularly in those used to produce extrusion profiles.
Patent EP-1546122-B8 (EP)
Title: Procede de fabrication du valsartan
Inventor: DENNI-DISCHERT DONATIENNE
IPC: C07D257/04
Filed: 2003-09-22
Granted: 2008-05-28
Abstract: La présente invention a trait à un procédé de fabrication de Valsartan, un bloqueur du récepteur de l'angiotensine (ARB ; aussi désigné antagoniste du récepteur de l'angiotensine II ou antagoniste du récepteur AT1) et ses sels, à de nouveaux intermédiaires et à des étapes de traitement.
Patent EP-1587847-B8 (EP)
Title: Procede de raffinage de resine brute destinee a du materiel electronique
Inventor: HADA HIDEO
IPC: C11B/
Filed: 2004-01-28
Granted: 2008-09-24
Abstract: L'invention concerne un procédé permettant de retirer efficacement des sous-produits, tels que des oligomères, d'une résine brute destinée à du matériel électronique, et de produire ainsi une résine pour du matériel électronique. Ce procédé consiste à sélectionner une résine brute destinée à du matériel électronique, contenant (a1) des unités structurales dérivées d'un ester de (méth)acrylate comportant un site hydrophile, puis à laver cette résine brute destinée à du matériel électronique avec (b1) un solvant organique capable de dissoudre ladite résine brute et de la diviser en deux couches lorsqu'elle est mélangée à de l'eau, et (b2) de l'eau.
Patent EP-1759091-B8 (EP)
Title: Roue de turbine d'une turbine a gaz d'echappement d'un turbocompresseur a gaz d'echappement
Inventor: SCHMID WOLFRAM
IPC: F01D5/04
Filed: 2005-06-11
Granted: 2008-01-23
Abstract: L'invention concerne une roue de turbine d'une turbine à gaz d'échappement. Cette roue comprend un moyeu de roue et une pluralité d'aubes qui sont placées sur le moyeu de roue de turbine et qui s'étendent axialement entre une entrée de roue de turbine et une sortie de roue de turbine. Les aubes sont réalisées de telle façon que le rapport entre l'épaisseur du contour de moyeu et l'épaisseur du contour externe de chaque aube suit une fonction prédéterminée.
Patent BR-PI0414107-B8 (BR)
Title: produtos intermediários para a preparação de híbridos de oxazolidinon-quinolona
Inventor: CHRISTIAN HUBSCHWERLEN
IPC: C07D413/12
Filed: 2004-09-03
Abstract: "produtos intermediários para a preparação de híbridos de oxazolidinon-quinolona". a presente invenção descreve produtos intermediários (zp) para uma síntese nova e eficiente de compostos, nos quais os farmacóforos de quinolona e oxazolidinona estão ligados uns com os outros através de um ligante quimicamente estável.
Patent BR-PI0605481-B8 (BR)
Title: sistema de reforço pré-fabricado em fibro-resina no formato de pônticos
Inventor: Roberto Queiróz Martins Alcântara
IPC: A61C13/103
Filed: 2006-10-30
Abstract: SISTEMA DE REFORÇO PRÉ-FABRICADO EM FIBRO-RESINA NO FORMATO DE PÔNTICOS, descreve-se a presente patente de invenção a um sistema odontológico em geral, mais especificamente a um "Sistema de Reforço Pré-Fabricado em Fibro-Resina no Formato de Pônticos", (5) que, de acordo com suas características gerais possui o formato ligeiramente menor ao das coroas dos dentes naturais para uso particular no ramo odontológico, relaciona-se a um sistema para ser utilizado sobre os preparos dos dentes adjacentes a perda dental como elemento de suporte para apoio de dentes artificiais (C), nos casos de perda do dente natural. Com design e formato específico e de fácil acesso para melhor adaptação e segurança dos usuários, o "Sistema de Reforço Pré-Fabricado em Fibro-Resina no Formato de Pônticos" (5), devido as suas características gerais, dimensões e com vistas a possibilitar a sua aplicação como suporte, tendo como base, um sistema de ponte (1) com grande resistência, infere que a atual técnica protética objetiva tomar possível solucionar alguns dos principais inconvenientes das demais formas e modelos conhecidos pelo atual estado da técnica, e que traz soluções para ambos os problemas do reforço (4) obtido pela técnica direta.
Patent BR-PI0720972-B8 (BR)
Title: compostos análogos de ciclopamina e composições farmacêuticas compreendendo os referidos compostos
Inventor: ALFREDO C CASTRO
IPC: A01N43/42
Filed: 2007-12-27
Abstract: compostos análogos de ciclopamina, composições farmacêuticas compreendendo os referidos compostos, e processos para a preparação dos mesmos. a presente invenção refere-se a derivados da ciclopamina tendo a seguinte fórmula.
Patent BR-PI0823082-B8 (BR)
Title: composições de derivados de sesquiterpeno para prevenir ou tratar hiperlipidemia, fígado gordo, diabetes ou obesidade
Inventor: HA-WON KIM
IPC: A61K31/19
Filed: 2008-10-20
Abstract: uso de derivados de sesquiterpeno a presente invenção se refere a uma composição farmacêutica para prevenir ou tratar hiperlipidemia, fígado gordo, diabetes e obesidade que compreende um derivado de sesquiterpeno como um ingrediente ativo. os derivados de sesquiterpeno da presente invenção levam à diminuição em peso de gordura corporal, peso de gordura visceral e níveis de colesterol totais, triglicerídeo de plasma e tecido do fígado, níveis de glicose sanguínea e insulina sanguínea em um estado rápido, exibindo finalmente eficácias em prevenção ou tratamento de hiperlipidemia, fígado gordo, diabetes e obesidade. a presente invenção se refere a uma composição farmacêutica para prevenir ou tratar hiperlipidemia, fígado gordo, diabetes e obesidade que compreende um derivado de sesquiterpeno como um ingrediente ativo. os derivados de sesquiterpeno da presente invenção levam à diminuição em peso de gordura corporal, peso de gordura visceral e níveis de colesterol totais, triglicerídeo de plasma e tecido do fígado, níveis de glicose sanguínea e insulina sanguínea em um estado rápido, exibindo finalmente eficácias em prevenção ou tratamento de hiperlipidemia, fígado gordo, diabetes e obesidade.
Patent BR-PI0903700-B8 (BR)
Title: sistema magnético para vetorização de antibióticos para tratamento de infecções por helicobater pylori
Inventor: ALDO DA CUNHA DE MEDEIROS
IPC: A61M31/00
Filed: 2009-05-04
Abstract: sistema magnético para vetorização de antibióticos para tratamento de infecções por helicobacter pylori. patente de invenção de sistema magnético para vetorização de antibióticos para o tratamento de infecções por helicobacter pylori. o sistema é composto de micropartículas de magnetita revestidas por polímero gastroresistente e contendo antibiótico. a terapêutica atual tem limitações diversas. como terapia alternativa propõe-se nesse invento a vetorização do antimicrobiano por meio de partículas superparamagnéticas guiadas através de um campo externo para o sítio de ação. adicionalmente, o sistema de vetorização magnética permite aumentar a permanência do medicamento no sítio de ação. o sistema proposto baseia-se na administração por via oral do antibiótico complexado ao vetor magnético por meio de estrntura polimérica formando micropartículas com resposta magnética. um ímã externo localizado no abdômen deve ser utilizado a fim de promover a permanência das partículas no local de interesse. a força atrativa exercida pelo campo magnético é utilizada para aproximar as micropartículas da superfície da mucosa onde o gradiente de ph é elevado, o que favorecerá a degradação do polímero e consequente liberação do fármaco mais próximo da bactéria. essa técnica é capaz de promover o emprego de menor quantidade de fármaco e/ou frequência de administrações.
Patent BR-PI0915112-B8 (BR)
Title: cateter de entalhe para tratar válvulas cardíacas doentes
Inventor: JUAN F GRANADA
IPC: A61B17/3207
Filed: 2009-06-04
Abstract: cateter de entalhe para tratar válvulas cardíacas doentes. a presente invenção refere-se a um cateter de valvuloplastia que tem um elemento de entalhe em sua parte distal para entalhar válvulas cardíacas calcificadas, estenóticas em direção radial e fazer as abas/folhetos de válvula única funcionar novamente. em adição a isto, o dispositivo poderia compreende um balão anexo para pós-dilatar a válvula depois do procedimento de entalhe. para reduzir uma recalcificação futura, o elemento de entalhe e/ou o balão têm revestimento farmacológico em sua superfície externa.
Patent BR-PI1013259-B8 (BR)
Title: moduladores lxr
Inventor: BOLLU VENKATAIAH
IPC: A61P3/00
Filed: 2010-05-26
Abstract: compostos, sal farmaceuticamente aceitáveis, isômeros, ou pró drogras destes, da invenção são revelados, que são revelados, que são úteis como moduladores da atividade de receptores x do fígado (lxr). composições farmacêuticas contendo os compostos e métodos de uso dos compostos são também revelados.
Patent EA-025302-B8 (EA)
Title: Pyrazoles derivatives modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer
Inventor: MUTHUPPALANIAPPAN MEYYAPPAN
IPC: C07D487/04
Filed: 2010-10-07
Abstract: Disclosed are novel calcium release-activated calcium (CRAC) channel inhibitors, which are compounds of general formula (I)or pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions containing said compounds and methods for treating non-small cell lung cancer (NSCLC) with said CRAC inhibitors.
Patent DK-180866-B8 (DK)
Title: Apparatus for performing multiple downhole operations in a production tubing
Inventor: BÅRD MARTIN TINNEN
IPC: E21B33/13
Filed: 2020-06-11
Granted: 2022-08-02
Abstract: It is described a downhole apparatus (1), the downhole apparatus (1) comprising: - a sleeve (2) - a tool string (3) - a plug (4) - a means (41) for setting the plug (4) wherein an upper portion (210) of the sleeve (2) is connectable to a lower portion (310) of the tool string (3), and a lower portion (211) of the sleeve (2) is arranged to receive the plug (4) and the means (41) for setting the plug (4). A method for using the downhole apparatus (1) is described as well.