baber/WOPTO huggingface dataset:
Patent WO-2019207087-A1 (WO)
Title: Combination therapy including beta-sitosterol in combination with at least one of a braf inhibitor, a mek inhibitor and an erk inhibitor and methods and use thereof
Inventor: BJERKVIG ROLF
IPC: A61K31/519
Filed: 2019-04-26
Abstract: The present invention relates in a first aspect to a pharmaceutical composition comprising beta-sitosterol or a homolog thereof in combination with a BRAF inhibitor and/or a MEK inhibitor and/or an ERK inhibitor. In particular, the present invention relates to a combination of the beta-sitosterol in combination with a BRAF inhibitor like vemurafenib, PLX4720 or dabrafenib or the MEK inhibitor trametinib. The composition is particularly useful in the treatment of cancer including metastatic cancer for example by oral or intravenous administration of both. The beta-sitosterol and the at least one of the BRAF inhibitor and/or MEK inhibitor and/or an ERK inhibitor being administered simultaneously, separately or sequentially. In a further aspect, a method of treating individuals suffering from cancer using the pharmaceutical composition according to the present invention is disclosed.
Patent WO-2019224004-A1 (WO)
Inventor: OTTNAD JENS
IPC: G05B19/406
Filed: 2019-05-08
Abstract: The invention relates to a method (28) for handling a workpiece (14) with the aid of a removal tool (18), having the method steps of: B) generating at least one parameter for the removal tool (18); C) determining at least one characteristic variable from the at least one parameter and at least one item of workpiece information; D) creating a removal prediction taking into account the characteristic variable and at least one removal result from a removal result store (24); E) assessing the removal prediction; F) removing the workpiece (14) in the event of a positive removal prediction; G) detecting the removal result; H) storing the removal result in the removal result store (24). The invention also relates to a machine for carrying out such a method.
Patent WO-2019219775-A1 (WO)
Title: Use of fungicides and glycine betaine in combination for controlling fungal plant pathogens
Inventor: SANCHEZ JEAN-MARC
IPC: A01P3/00
Filed: 2019-05-15
Abstract: The present disclosure concerns the use of a new combination for reducing the amount of fungicides required to control harmful fungal plant pathogens.
Patent WO-2019224192-A1 (WO)
Title: Inductive energy emitter/receiver for an inductive charger of an electric vehicle
Inventor: CAÑETE CABEZA CLAUDIO
IPC: H01F27/26
Filed: 2019-05-21
Abstract: Inductive energy emitter/receiver for an inductive charger of an electric vehicle Inductive energy emitter/receiver including a planar-shaped magnetic core (10) with two opposed main surfaces (S); at least one conductive coil (20) wound around an axis (A) perpendicular to the main surfaces (S) of the planar-shaped magnetic core (10), said conductive coil (20) being overlapped to one of said main surfaces (S) of the magnetic core (10); an inductor casing (30) being attached to said planar-shaped magnetic core (10) and said at least one conductive coil (20). The inductor casing (30) is at least partially made of flexible polymer bonded soft magnetic material, and the planar- shaped magnetic core (10) is a made of a plurality of flexible elongated partial cores (11), forming a flexible planar-shaped magnetic core (10).
Patent WO-2020007542-A1 (WO)
Title: Ladevorrichtung und pakettransportfahrzeug mit einer ladevorrichtung
Inventor: LISCHNEWSKI PHILIPP
IPC: B60P1/36
Filed: 2019-05-29
Abstract: Die Erfindung betrifft eine Ladevorrichtung (1), insbesondere für einen Laderaum (9) eines Pakettransportfahrzeugs (8), mit einer Transportbahn (2), auf welcher Packstücke (58) angeordnet sind, und mit einer Schubeinrichtung (6), die eine zwischen zwei einander entgegengesetzten, seitlichen Enden (3, 4) der Transportbahn (2) bewegbare Schubeinheit (7) aufweist, mittels welcher auf der Transportbahn (2) angeordnete Packstücke (58) entlang dieser verschiebbar sind. Erfindungsgemäß ist vorgesehen, dass die Schubeinheit (7) ein Verschlusselement (10) umfasst, welches zumindest an einem der beiden Enden (3, 4) zwischen einer Betriebsstellung, in welcher das Verschlusselement (10) die Transportbahn (2) begrenzt, und einer Beladestellung, in welcher das Verschlusselement (10) die Transportbahn (2) freigibt, verstellbar ist.
Patent WO-2019229189-A1 (WO)
Title: Soil tillage implement and method for folding sections of soil tillage implement
Inventor: PASQUIER GAËTAN
IPC: A01B73/04
Filed: 2019-05-29
Abstract: The invention refers to a soil tillage implement (1), comprising a main frame (2). On each of opposite sides of the main frame (2), the following is provided: a first working section (6,1, 6,2) extending in both a longitudinal direction and a transversal direction of the main frame (2) and having a first subframe (8.1, 8.2) and first soil working tools (9.1, 9.2) received on the first subframe (8.1, 8.2); a first articulation (10.1, 10.2) extending essentially parallel to the longitudinal direction and provided proximal with respect to the main frame (2), the first working section (6.1, 6.2) relocatable around the first articulation (10.1, 10.2) between a working position in which the first working section (6.1, 6.2) is oriented essentially horizontally with the first working tools oriented to the soil and a transport position in which the first working section (6.1, 6,2) is provided in an essentially upright position; a second working section (11.1, 11.2) extending in both the longitudinal direction and the transversal direction of the main frame (2) and having a second subframe (15.1, 15.2) and second soil working tools (16.1, 16.2) received on the second subframe (15.1, 15.2) (15.1, 15.2), the second working section (11.1, 11.2) together with the first working section (6,1, 6.2) providing for a combined working width in the transversal direction; a free section (13.1, 13.2) extending in both the longitudinal direction and the transversal direction of the main frame (2) and being free of soil working tools, the free section (13.1, 13.2) located between the main frame (2) and the second working section (11.1, 11.2), thereby, the first working section (6.1, 6.2) and the second working section (11.1, 11.2) being in an offset position along both the longitudinal and the transversal directions; and a second articulation extending essentially parallel to the longitudinal direction and provided distal with respect to the main frame (2), the second working section (11.1, 11.2) relocatable around the second articulation between a working position in which the second working section (11.1, 11.2) is oriented essentially horizontally with the second working tools oriented to the soil and a non-working position in which the second working section (11.1, 11.2) is provided above the free section (13.1, 13.2). Further, a method for folding sections of a soil tillage implement is provided.
Patent WO-2020244746-A1 (WO)
Title: Commande de fonctionnement mu-mimo
Inventor: FRYKING PER
IPC: H04B7/06
Filed: 2019-06-05
Abstract: L'invention concerne un procédé pour le fonctionnement à entrées multiples et sorties multiples multiutilisateur (MU-MIMO) d'un nœud d'accès desservant une pluralité de dispositifs utilisateurs. Ce procédé consiste à acquérir une catégorie de vitesse pour un dispositif d'utilisateur parmi la pluralité de dispositifs utilisateurs, et à commander le fonctionnement MU-MIMO par rapport au dispositif utilisateur sur la base de la catégorie de vitesse. Dans certains modes de réalisation, la commande du fonctionnement MU-MIMO par rapport au dispositif utilisateur sur la base de la catégorie de vitesse comprend un ou plusieurs éléments parmi : la commande de l'émission du signal de référence du dispositif utilisateur sur la base de la catégorie de vitesse, et la commande de l'affiliation de groupe MU-MIMO du dispositif utilisateur sur la base de la catégorie de vitesse. Dans certains modes de réalisation, la commande de l'émission de signal de référence du dispositif utilisateur sur la base de la catégorie de vitesse consiste à commander une durée d'un intervalle de temps entre des émissions de signal de référence ultérieures du dispositif utilisateur sur la base de la catégorie de vitesse. Dans certains modes de réalisation, la commande d'une affiliation de groupe MU-MIMO du dispositif utilisateur sur la base de la catégorie de vitesse consiste à trier le dispositif utilisateur dans l'une parmi une pluralité de groupes MU-MIMO lorsque la catégorie de vitesse du dispositif utilisateur est destinée à des dispositifs utilisateurs ayant une vitesse de mouvement qui ne dépasse pas un second seuil de vitesse, et à exclure le dispositif utilisateur de tous les groupes MU-MIMO lorsque la catégorie de vitesse du dispositif utilisateur concerne les dispositifs utilisateurs ayant une vitesse de mouvement qui dépasse le second seuil de vitesse. L'invention concerne également un appareil, un nœud de réseau et un produit programme informatique correspondants.
Patent WO-2020002235-A1 (WO)
Title: Monitoring and diagnostics system for a smart freight car
Inventor: LIKTOR BALAZS
IPC: B60T17/22
Filed: 2019-06-24
Abstract: A monitoring and diagnostics system for a rail car (10), comprising multiple sensor units (1a, 1b, and 1c), each comprising sensor devices (S) and a data transfer unit (D), wherein the set of sensor units comprise at least one power harvester (P), which is configured to convert ambient energy into electrical energy, and one energy storage means (E), which can be configured to store the electrical energy generated by the power harvester (P), a sensor hub (4) which comprises a communication subsystem (cs) and a receiver (5), wherein the data transfer units (D) are configured, so that the sensor units (1a, 1b, and 1c) transfer detected / measured data to the sensor hub (4) and the communication subsystem (cs) is configured, so that the sensor hub (4) transfers the data to the receiver (5), either with cable or wirelessly.
Patent WO-2020012036-A1 (WO)
Title: Variants of cd38 antibody and uses thereof
Inventor: DE GOEIJ BART
IPC: A61P35/02
Filed: 2019-07-15
Abstract: Antibody variants comprising one or more mutations in the Fc region, particularly anti-CD38 antibodies comprising a mutation in one or more amino acid residues corresponding to E430, E345 and S440 in a human IgG1 heavy chain, wherein the amino acid residues are numbered according to the EU index.
Patent WO-2020078602-A1 (WO)
Title: Linearmotorbetriebenes transportsystem mit kreisrunder transportbahn und betrieb desselben
Inventor: NEUBAUER MICHAEL
IPC: B65G47/84
Filed: 2019-08-14
Abstract: Die vorliegende Erfindung stellt ein Transportsystem zum Transport von Stückgut und ein Ver- fahren zum Betrieb desselben zu Verfügung, wobei das Transportsystem eine im Wesentli- chen kreisrunde Transportbahn mit wenigstens einem Langstator (285) eines Linearmotors und wenigstens einem Führungselement (280) und eine Vielzahl von einzeln steuerbaren Transportelementen (270), die an dem wenigstens einen Führungselement (280) bewegbar gelagert sind, umfasst, wobei das wenigstens eine Führungselement (280) und/oder der we- nigstens eine Langstator (285) um eine Rotationsachse durch den Mittelpunkt (264) der Trans- portbahn rotierbar ausgebildet sind.
Patent WO-2020070313-A1 (WO)
Title: Pharmaceutical compositions comprising bispecific anti-cd37 antibodies
Inventor: OOSTINDIE SIMONE
IPC: C07K16/28
Filed: 2019-10-04
Abstract: The disclosure relates to pharmaceutical compositions comprising CD37-specific bispecific antibody molecules binding to different epitopes of the human CD37 antigen which bispecific antibody molecules have enhanced Fc-Fc interactions upon binding to CD37 on the cell surface. The disclosure also relates to use of these pharmaceutical compositions for the treatment of cancer and other diseases.
Patent WO-2020104187-A1 (WO)
Title: Kunststoffbehälter mit wenigstens bereichsweise scharfkantig ausgebildeter behältergeometrie und verfahren zur herstellung des kunststoffbehälters
Inventor: SIEGL ROBERT
IPC: B29C49/10
Filed: 2019-11-05
Abstract: Es ist ein Kunststoffbehälter beschrieben, der aus einem Preform mit einem Massenanteil von wenigstens 80% Polyester und gegebenenfalls wenigstens einem Zusatzstoff aus der Gruppe bestehend aus Farbstoffen, Füllstoffen, Katalysatoren, Additiven und Gleitadditiven gefertigt ist. Der Kunststoffbehälter weist einen Behälterhals und eine an den Behälterhals anschliessende Behälterschulter auf, die in einen mit einem Behälterboden verschlossenen Behälterkörper übergeht. Die Behälterschulter, der Behälterboden und der Behälterkörper sind in einem 2-Stufen-Streckblasverfahren ausschliesslich mittels eines Blasverfahrens umgeformt. Das Polyester ist ein Copolyester und weist Gruppen auf, welche von den Monomeren Cyclohexandimethanol (CHDM) und/oder Monoethylenglykol (MEG), Terephtalatsäure (TPA) oder deren Derivate und Isophtalsäure (IPA) oder deren Derivate ab stammen. Wenigstens ein Teilbereich des Behälterkörpers und/oder der Behälterschulter weist eine scharfe Kante mit einem Radius von weniger als 0,5 mm auf. Es ist auch ein Verfahren zur Herstellung des Kunststoffbehälters beschrieben.
Patent WO-2020120335-A1 (WO)
Inventor: KUCHLER MARKUS
IPC: F24C7/08
Filed: 2019-12-06
Abstract: Verfahren (S1-S11) zum Betreiben eines Haushalts-Gargeräts (1), aufweisend mindestens eine Gargutbehandlungseinrichtung (6) zum Behandeln von in dem Garraum (2) befindlichem Gargut (G) mit mehreren Parameterkonfigurationen (Sq), wobei durch mindestens zwei Parameterkonfigurationen (Sq) das Gargut (G) lokal unterschiedlich behandelbar ist, und mindestens einen in einen Garraum (2) gerichteten Sensor (9) zum Bestimmen von Messwertverteilungen <V> einer Oberflächeneigenschaft des Garguts (G), wobei bei dem Verfahren die mindestens eine Gargutbehandlungseinrichtung für eine vorgegebene Zeitdauer (Δt) mit einer der Parameterkonfigurationen (Sq) betrieben wird, um das Gargut (G) zu behandeln, anschließend an den Ablauf einer Zeitdauer (Δt) mittels des mindestens einen Sensors (9) eine Messwertverteilung < V > einer Oberflächeneigenschaft des Garguts (G) bestimmt wird, aus der Messwertverteilung < V > ein Qualitätswert (Q) bestimmt wird und, falls der Qualitätswert (Q) ein vorgegebenes Qualitätskriterium nicht erfüllt, die Gargutbehandlungseinrichtung (6) folgend einer anderen der Parameterkonfigurationen (Sq) betrieben wird, wobei der Qualitätswert (Q) aus einem Vergleich zweier unterschiedlicher, aus der gleichen Messwertverteilung < V > berechneten skalaren Größen (xarithm, xmed) bestimmt wird.
Patent WO-2020126625-A1 (WO)
Title: P450 split enzyme as well as products, methods and uses relating thereto
Inventor: BOCOLA MARCO
IPC: C12N9/02
Filed: 2019-12-09
Abstract: The present invention relates to a P450 monooxygenase enzyme, a nucleic acid encoding the P450 monooxygenase enzyme, a cell comprising the P450 monooxygenase enzyme or the nucleic acid, a kit for detecting sortase activity comprising the P450 monooxygenase enzyme, the use of the P450 monooxygenase enzyme for detecting sortase activity and a method for detecting sortase activity comprising detecting a change in the signal of the P450 monooxygenase enzyme.
Patent WO-2020126920-A1 (WO)
Inventor: DROBYSHEV KIRILL
IPC: B01J23/92
Filed: 2019-12-13
Abstract: The present invention relates to a method for producing butadiene from ethanol, in two reaction steps, comprising a step a) of converting the ethanol into acetaldehyde and a step b) of conversion into butadiene, the step b) simultaneously implementing a reaction step and a regeneration step in (n+n/2) fixed-bed reactors, n being equal to 4 or to a multiple thereof, comprising a catalyst, said regeneration step comprising four consecutive regeneration phases, the step b) also implementing three regeneration loops.
Patent WO-2020156740-A1 (WO)
Title: Compositions d'ester de cellulose pour revêtements de surface
Inventor: BASTIN PIERRE
IPC: C08L67/00
Filed: 2019-12-18
Abstract: La présente invention concerne un revêtement de surface, en particulier un revêtement de sol ou de mur, comprenant au moins une couche polymère comprenant un mélange de polymères, ledit mélange de polymères comprenant de 6,5 à 93,5 % en poids d'un ester de cellulose et de 93,5 à 6,5 % en poids d'un ou plusieurs polymères choisis dans le groupe constitué par des (co)polymères comprenant un (méth)acrylate, des (co)polymères comprenant un alcanoate de vinyle, des (co)polymères de vinylacétals, des (co)polyesters, des (co)polyamides, des polyuréthanes, des (co)polymères de nitrile, des (co)polymères de styrène, des (co)polymères de chlorure de vinyle, des (co)polymères oléfiniques et des ionomères.
Patent WO-2020192974-A1 (WO)
Title: Apparatus for pumping fluids
Inventor: BONNEFOUS PATRICE
IPC: F17C13/12
Filed: 2020-03-27
Abstract: The present invention relates to an apparatus for pumping flammable fluids like refrigerated liquefied gases, comprising a pump (5) (for pumping the fluid) having a longitudinal axis; a pneumatically actuated valve (8) fluidly connected to the inlet of the pump (5); and a pneumatic line (9) made of a fusible material connected to the pneumatic valve (8) for supplying actuation pneumatic fluid to the pneumatic valve (8); wherein the pneumatic line passes along the longitudinal axis of the pump (5).
Patent WO-2020182374-A1 (WO)
Title: Vehicle control system and method
Inventor: NEILSON ROBERT
IPC: B60G17/018
Filed: 2020-02-05
Abstract: Embodiments of the present invention provide a control system (100) for determining a suspension calibration of a vehicle (800). The control system (100) has one or more controllers (120) that receive route data indicative of a route ahead of the vehicle (800). One or more processors (130)determine, from the route data,a prediction of a first acceleration at a first location (320) ahead of the vehicle (800) and a second acceleration at a second location (330) ahead of the first location(320).The one or more processors (130) determine a suspension calibration of the vehicle (800) in dependence on the second acceleration. The actual acceleration of the vehicle (800) is measured at the first location (320)and compared with the first acceleration. If the measured and first acceleration are within a predetermined tolerance, the processor (120) produces a suspension control signal at output (121) which is received by a suspension controller (140) to apply the suspension calibration prior to the vehicle (800)arriving at the second location(330).
Patent WO-2020165090-A1 (WO)
Title: Dispositif de positionnement pour machines-outils et centres d'usinage
Inventor: BRONZINO PIER MAURO
IPC: B23Q1/00
Filed: 2020-02-10
Abstract: L'invention concerne de multiples inserts de verrouillage (32) qui peuvent coulisser de manière étanche dans des sièges de guidage respectifs (36) d'un corps (12) afin de se déplacer en translation entre une position de verrouillage et une position de chargement/déchargement. Des moyens soupape (52) comprennent un corps de soupape (54), qui est inséré de manière étanche dans un siège de guidage (36) et a une surface avant (56) qui fait face à une surface d'extrémité (58) de l'insert de verrouillage respectif (32) qui est opposée à une extrémité de préhension (37), et un trou calibré (60) qui s'étend de la surface avant (56) à l'atmosphère. Un circuit pneumatique (64, 66, C, P) fournit de l'air sous pression dans le siège de guidage (36) entre le corps de soupape (54) et l'insert de verrouillage (32). Avec l'insert de verrouillage (32) dans la position de chargement/déchargement, la surface d'extrémité (58) vient en butée frontalement contre la surface avant (56) de façon à obstruer l'écoulement d'air à travers le trou calibré (60). Des moyens de détection (S) détectent l'augmentation conséquente de la pression et génèrent un signal de dégagement correspondant (A).
Patent WO-2020165115-A1 (WO)
Inventor: LICHTINGER KLAUS
IPC: F02M61/18
Filed: 2020-02-11
Abstract: The invention relates to a nozzle for a fuel injector, having a rotationally symmetrical nozzle body with a cavity for introducing a nozzle needle, a nozzle tip which is provided at a longitudinal end of the nozzle body, and at least one linear opening channel for discharging fuel, and a nozzle needle which is arranged in the cavity for selectively blocking a flow of fuel to the at least one opening channel. The nozzle is characterized in that the at least one opening channel has a central axis which is inclined to the longitudinal axis of the nozzle body.
Patent WO-2020193202-A1 (WO)
Title: Smoking substitute system
Inventor: BENYEZZAR MED
IPC: A61M11/04
Filed: 2020-03-13
Abstract: A heat-not-burn device is described. The device includes a controller having a cyclic operating routine. The controller is configured to, during each cycle of the cyclic operating routine, perform at least one function of the device. A period of the cyclic operating routine is between 10 milliseconds and 500 milliseconds.
Patent WO-2020187771-A1 (WO)
Inventor: SOHN MYRIAM
IPC: A61K8/41
Filed: 2020-03-13
Abstract: La présente invention concerne des compositions d'écran solaire ou de soins quotidiens comprenant de l'hexyl 2-[4-(diéthylamino)-2-hydroxybenzoyl]benzoate (INCI diéthylamino hydroxybenzoyl hexyl benzoate) et au moins un filtre UVA soluble dans l'eau, la composition ne comprenant pas de 2-hydroxy-4-méthoxybenzophénone (INCI oxybenzone) ni d'éthylhexyl-2-cyano-3,3-diphényl-acrylate (INCI octocrylène). En outre, la présente invention concerne l'utilisation de ladite composition pour réduire la coloration des tissus et accroître la lavabilité d'une composition d'écran solaire ou de soins quotidiens.
Patent WO-2020207881-A1 (WO)
Inventor: RITTIG FRANK
IPC: C10N20/00
Filed: 2020-04-01
Abstract: La présente invention concerne un procédé de traitement d'une pièce à usiner comprenant la mise en contact d'un outil et d'une pièce à usiner pour effectuer un changement de forme de la pièce à usiner, et l'application d'un fluide de travail des métaux sur une zone de surface où l'outil et la pièce à usiner sont en contact, le fluide de travail des métaux contenant un propoxylate de formule R-O-(C 3 H 6 O) n -H, R étant un alkyle en C 6  à C 20  ramifié et n est de 3 à 30. L'invention concerne en outre un fluide de travail des métaux, ainsi qu'une utilisation du propoxylate en tant qu'additif dans des fluides de travail des métaux.
Patent WO-2020225161-A1 (WO)
Title: Method and apparatus for controlling transmission on preconfigured uplink resources in a wireless communication network
Inventor: THANGARASA SANTHAN
IPC: H04W56/00
Filed: 2020-05-01
Abstract: A wireless device (12) "relaxes" the radio-signal measurements it makes with respect to a wireless communication network (10), in the context of using those measurements to determine whether a current Timing Advance,TA, value remains valid for use in transmitting on preconfigured uplink resources,PUR, of the wireless communication network (10). Relaxation refers to the length of the interval between making new measurements. According to techniques herein, the wireless device (12) operates according to an imposed limit on the extent or degree of relaxation, to ensure or at least improve the reliability of the radio measurements with respect to validation of the TA value. Determination of the extent of relaxation occurs at the wireless device (12) or at a supporting network node (22) of the wireless communication network (10).
Patent WO-2020234166-A1 (WO)
Inventor: GOCH MICHAEL
IPC: A24F40/50
Filed: 2020-05-15
Abstract: The invention is directed to a method for controlling an electronic vapor generation device (1 ) for a user (2) to inhale consumable vapor (3) in a session (S) containing several puffs (P)„ wherein a heater (4) generates consumable vapor (3) from a consumable (5) and is controlled by a controller (6) according to a control strategy (7), It is proposed, that the controller comprises a control mechanism (8), which collects a consumption pattern (9) of the user (2) and which sets the control strategy (7) based on the collected consumption pattern (9).