Patent SG-11201908420W-A (SG)
Title: Compositions of plinabulin and use thereof
Inventor: MOHANLAL RAMON
IPC: A61K39/395
Filed: 2018-03-12
Abstract: 20 30 Plinabulin Dose mg/m 2 N = number of patients tested 60 N = 50 50 N = 40 40 - N = 73 30 - 20 10 % p a t ien ts w ith s tero id re late d a dverse events 0 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIP0 I PCT omit IIl °nolo Imo oimIE (10) International Publication Number WO 2018/169887 Al (51) International Patent Classification: A61K 31/40 (2006.01) A61K 39/395 (2006.01) A61K 31/04 (2006.01) A61P 35/00 (2006.01) A61K 31/496 (2006.01) A61P 37/00 (2006.01) (21) International Application Number: PCT/US2018/022064 (22) International Filing Date: 12 March 2018 (12.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/470,802 13 March 2017 (13.03.2017) US 62/621,528 24 January 2018 (24.01.2018) US (71) Applicant: BEYONDSPRING PHARMACEUTICALS, INC. [US/US]; 28 Liberty Street, 39th Floor, New York, NY 10005 (US). (72) Inventors: MOHANLAL, Ramon; c/o Beyondsp/Be- yondSpring Pharmaceuticals, Inc., 28 Liberty Street, 39th Floor, New York, NY 10005 (US). HUANG, Lan; c/o Beyondsp/BeyondSpring Pharmaceuticals, Inc., 28 Liberty Street, 39th Floor, New York, NY 10005 (US). LLOYD, George, Kenneth; c/o Beyondsp/BeyondSpring Pharma- ceuticals, Inc., 28 Liberty Street, 39th Floor, New York, NY 10005 (US). (74) Agent: ALTMAN, Daniel, E.; Knobbe, Martens, Olson & Bear, LLP, 2040 Main Street, 14th Floor, Irvine, CA 92614 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, W O 20 18/ 169887 Al (54) Title: COMPOSITIONS OF PLINABULIN AND USE THEREOF FIG. 1 (57) : Disclosed herein are compositions and methods of preventing and/or treating or reducing immunotherapy mediated adverse events by administering plinabulin. Some embodiments relate to treatment of immunotherapy related inflammation by admin- istering plinabulin. Some embodiments relate to treatment of psoriasis and/or inflammation by administering plinabulin. [Continued on next page] WO 2018/169887 Al MIDEDIMOMOIDEIREEMOMOHEIMMEHIMEN GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))