Patent SG-11201903840W-A (SG)
Title: Method
Inventor: ANTONIADES CHARALAMBOS
IPC: G06T7/00
Filed: 2017-10-31
Abstract: FAIPVATB) - FAIPVAT FAIPVAT y -82 c ' - e ) -84 -86 - 88 FAIPVAT (FAIPVAr - FAInan-PVAT) Distance from the RCA wall (mm) VPCI-100x Attenuation map (HU) Water Fat LaFF4 +15 -15 -20 -190 in (A) D VPCI (%) FPI tertiles — Low -- Mid ---- High FIGURE 1 W O 20 18/07 8395 Al VPCI (%) VPCI (/r) 2 4 6 8 10 12 14 16 18 20 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 03 May 2018 (03.05.2018) WIPO I PCT omit ° oI0IIIIIIIIIIV111mull oimIE (10) International Publication Number WO 2018/078395 Al (51) International Patent Classification: A61B 6/03 (2006.01) GO6T 7/62 (2017.01) GO6T 7/00 (2017.01) (21) International Application Number: PCT/GB2017/053262 (22) International Filing Date: 31 October 2017 (31.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 20160100555 31 October 2016 (31.10.2016) GR 1620494.3 02 December 2016 (02.12.2016) GB (71) Applicant: OXFORD UNIVERSITY INNOVATION LIMITED [GB/GB]; Buxton Court, 3 West Way, Botley OX2 OSZ (GB). (72) Inventors: ANTONIADES, Charalambos; Level 6 West Wing, John Radcliffe Hospital, Headington, Oxford OX3 9DU (GB). CHANNON, Keith; Level 6 West Wing, John Radcliffe Hospital, Headington, Oxford OX3 9DU (GB). OIKONOMOU, Evangelos; Level 6 West Wing, John Radcliffe Hospital, Headington, Oxford OX3 9DU (GB). NEUBAUER, Stefan; Level 6 West Wing, John Radcliffe Hospital, Headington, Oxford OX3 9DU (GB). (74) Agent: GILL JENNINGS & EVERY LLP et al.; The Broadgate Tower, 20 Primrose Street, London Greater Lon- don EC2A 2ES (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: METHOD (57) : The present invention describes a new functional bio- marker of vascular inflammation and its use in predicting all-cause or cardiac mortality. The invention also provides a method for stratifying patients according to their risk of all-cause or cardiac mortality using data gathered from a computer tomography scans of a blood vessel to determine a specific combination of structural and functional bio- markers of vascular inflammation and disease. [Continued on next page] WO 2018/078395 Al MIDEDIMOMMIDIREIDINIMIERIMEMOVOIS TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))