baber/WOPTO huggingface dataset:
Patent SG-11201909825V-A (SG)
Title: Hsp90 inhibitor oral formulations and related methods
Inventor: AMEDIO JOHN
IPC: A61K31/7036
Filed: 2018-04-24
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT IiiimmoimiolollmonolooloionsiollommovoimIE (10) International Publication Number WO 2018/200534 Al (51) International Patent Classification: A61K 9/20 (2006.01) A61K 31/52 (2006.01) A61K 9/22 (2006.01) A61K 31/7036 (2006.01) A61K 31/33 (2006.01) CO7D 473/32 (2006.01) A61K 31/395 (2006.01) CO7D 473/34 (2006.01) (21) International Application Number: PCT/US2018/029157 (22) International Filing Date: 24 April 2018 (24.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/489,438 24 April 2017 (24.04.2017) US 62/489,434 24 April 2017 (24.04.2017) US 62/532,985 14 July 2017 (14.07.2017) US 62/532,987 14 July 2017 (14.07.2017) US 62/588,893 20 November 2017 (20.11.2017) US 62/588,897 20 November 2017 (20.11.2017) US 62/627,229 07 February 2018 (07.02.2018) US 62/627,237 07 February 2018 (07.02.2018) US (71) Applicant: SAMUS THERAPEUTICS, INC. [US/US]; 10 South Main Street, Topsfield, MA 01983 (US). (72) Inventor: AMEDIO, John; 6 Ginny Lane, Franklin, MA 02038 (US). (74) Agent: TREVISAN, Maria, A.; Wolf, Greenfield & Sacks, P.C., 600 Atlantic Avenue, Boston, MA 02210-2206 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, = (54) Title: HSP90 INHIBITOR ORAL FORMULATIONS AND RELATED METHODS Final Blend Compression Delayed Release Coating Encapsulate: DR Capsules Encapsulate: DR Capsules Encapsulate: DR Capsules Encapsulate: DR Capsules PG. 1 (57) : Provided herein are novel and improved oral formulations for Hsp90 inhibitors. C ug Substance/Excipients Blend Mg Stearate [Continued on next page] WO 2018/200534 Al MIDEDIMOMMIDIRE101001010111MEIIINHEMOVOIS MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))
Patent AT-404478-B (AT)
Title: Cooking liquor containing low b.pt. solvents and quinone reducing catalysts - contains alkali sulphite(s) and sulphide(s) in aqueous solution
Inventor: SCHUBERT HANS-LUDWIG DR
IPC: C08B1/08
Filed: 1996-02-02
Granted: 1998-11-25
Abstract: A process for the preparation of pulp by cooking material containing lignin in an alkaline aqueous cooking liquid which contains one or more low b.pt. solvents and one or more reducing catalysts - comprises the use of a liquid which contains aqueous solutions of alkali sulphites and sulphides. A similar process comprising the following steps is also claimed: (i) the lignin-containing cellulosic material is pre-hydrolysed with acid, steam and/or water in at least one step prior to cooking ; (ii) the material is impregnated with an alkaline liquor containing alkalis, sulphites and/or sulphides and optionally reducing catalysts ; (iii) the low b.pt. solvent is added before cooking, optionally along with the catalysts ; (iv) the pre-cooked material is cooked in a liquor containing at least one sulphide, at least one sulphite, at least one low b.pt. organic solvent (present in a concentration of ca. 2.5-60 %) and quinone reducing catalysts ; (v) the pulp is separated from the black liquor ; (vi) the solvent is recovered from the black liquor or directly from the cooking step equipment, and it may also be recovered from the associated kraft pulp line ; (vii) alkali present in the excess liquor and filtrate from the kraft pulp bleaching step is transferred to an evaporation and recovery step ; (viii) black liquor is evaporated, optionally as a mixture with the excess liquor from the bleaching step, to form a concentrated black liquor ; (ix) the concentrated black liquor is burnt under reducing conditions to form a solid residue ; (x) the residue is dissolved to form green liquor containing alkali carbonate and alkali sulphide ; (xi) the green liquor is divided into two parts ; (xii) the sulphur components are separated from at least one these parts using a sulphur separation method ; and (xiii) the sulphur-free solution is divided into two parts, one of which is treated to convert it into alkali sulphite for use in the (pre-)cooking step, whilst the other part is converted into sulphur-free hydroxide for use in the bleaching step. Preferably the solvent is methanol and the catalysts are chosen from quinone derivatives such as anthra(hydro)quinone. Sodium, potassium and/or ammonium sulphites and sulphides are used, to which the corresponding alkali hydroxides and/or (hydrogen) carbonates are added.
Patent AT-394835-B (AT)
Title: Container for discharging free-flowing substances
IPC: B65D1/32
Filed: 1989-04-10
Granted: 1992-06-25
Abstract: The invention relates to a container 1 which is intended for discharging free-flowing substances, can be changed between an expanded state and a collapsed state, and the walls of which 3, 4 enclose a space for receiving the free-flowing substance. For the purpose of changing the container volume, collapsible and foldable walls 4 are provided between two rigid side walls 3, and the container has an opening for the introduction and discharge of the free-flowing substance. In this case, the invention provides for the two rigid side walls 3 to be connected to one another in an articulated manner by means of a woven connecting material 5 along mutually adjacent terminating edges in each case, and for the rigid walls to diverge from the edge connected by the woven material when the container is in the expanded state. The other edges of the rigid walls are connected to one another by means of the collapsible or foldable walls 4. In the collapsed state of the container, the rigid side walls 3 butt against one another to give the container 1 a flattened configuration. Part of the collapsible or foldable walls 4 forms a base surface 2 for the container. <IMAGE>
Patent AT-408815-B (AT)
Title: Metre for electrical energy
Inventor: HOFER FRANZ DIPL-HTL-ING
IPC: G01R11/63
Filed: 1998-05-28
Granted: 2002-03-25
Abstract: Metre for electrical energy, having at least one pulse transmitter IG 1 for pulses whose frequency is proportional to the power Pact being drawn, having a time- dependent power model LMO which has an associated nominal pulse transmitter, in which the nominal pulse transmitter IG 2 of the time-dependent power model LMO is set up in order to emit pulses at a frequency which corresponds to the nominal power Pnom, the actual and nominal pulses are supplied to an upper reference step-up/down counter Z 2 and to a lower reference step-up/down counter Z 3, and a discriminator Z 4, BSS is provided which, depending on whether the actual power Pact is greater than or less than the nominal power Pnom, supplies enable signals FR+, FR- for the upper reference counter Z 2 and for the lower reference counter Z 3. <IMAGE>
Patent HU-184371-B (HU)
Title: Self-propelled bucket-wheel dredger
Inventor: WIMMER KLAUS
IPC: E02F9/12
Filed: 1981-01-21
Abstract: The superstructure, on a bottom carriage, has a boom turntable, mounted on the carriage to turn about a vertical axis, non- rotatably connected to an ejector boom. An arm supports the bucket wheel, with counterweight, rotatable relative to carriage and boom, on a travelling excavator. The excavator arm (22) is mounted on the turntable (3) so as to rotate about an axis (32) offset towards the discharge end (9) of the ejector boom (6). The ejector boom may be made without counterweight ballast, with the excavator arm pivoted axis sufficiently offset-for the overall centre of gravity to remain constantly within the required area. Weight is reduced without any sacrifice in boom length.
Patent HU-202834-B (HU)
Inventor: BAJUSZ FERENC
IPC: C07C263/00
Filed: 1986-01-15
Abstract: A találmány szerint úgy járnak el, hogy az aromás aminokat oldószeres közegben 80-160 *C hőmérsékleten, legfeljebb 0,5 MPa nyomáson csőreaktorban a reakcióelegy egy részének visszaforgatása mellett reagáltatják foszgénnel. Az aromás amin 300-2000 kg/h tömegáramú, max. 18 tömeg%-os oldatát, a foszgént vagy adott esetben oldószerben abszorbeáltától! foszgént és a véggázból visszanyert foszgén oldatot - olyan tömegáramban, hogy a betáplált foszgén és amin mólaránya legalább 5 :1 legyen - továbbá a gáz-folyadék elválasztóból visszaforgatott nyers reakcióelegyet, az aromás amin oldat tömegáramának 5-15-szörösét kitevő mennyiségben, keverőfejen keresztül csőreaktorba vezetik, majd innen a reakcióelegyet, ili. a nem kondenzált fázisban lévő anyagokat egy, a csőreaktorral azonos, 80-160 ’C hőmérsékleten és 0,1-0,5 MPa nyomáson működtetett gáz-folyadék elválasztóba vezetik, ahol gáz és folyadék fázist elválasztják. Az eljárás megvalósítására szolgáló berendezés ugyancsak a találmány tárgya, mely háromutas keverőfejet (9) tartalmazó csőreaktorból (10) áll a szokásos szétválasztó készülékeken kívül. A keverőfej (9) három csőből (a, b, c) áll, melyekhez a betápláló vezetékek csatlakoznak.  HU 202 834 A leírás terjedelme: 6 oldal, 2 rajz -1-
Patent HU-195068-B (HU)
Title: Method for grafting by alga and forming respectively increasing the productivity of soil
Inventor: PLOSZ SANDOR
IPC: A01G1/00
Filed: 1984-02-24
Abstract: Method for developing and increasing, resp., the fertility of soil which comprises, if necessary cleaning crude water and/or contaminated infiltrating water and subsoil water in a known way by leading it on an aquatic plant stand and thereby making it capable of irrigation, carrying out humus forming and enrichment on the soil to be treated by a soil alga by inoculating it with a soil alga of suitable productivity and propagating the alga with the help of irrigation and optionally enriching the irrigation water with a humus material prior to, during or after the treatment of the soil with the alga, and ensuring the presence of the plant nutrients in the irrigation water and the nutrient supply, resp., preferably continuously in organic material synthesized form.
Patent HU-200351-B (HU)
Title: Process for producing epoxy resin and cold crosslinking flexible and/or elastic epoxy resin compositions comprising epoxy resin
Inventor: SOOS LASZLO
IPC: C09K3/10
Filed: 1987-03-10
Abstract: The invention relates to low-temperature-crosslinking, flexible or elastic epoxy resin compositions which contain a condensate of an epoxidised phenolic resin and/or of an epoxidised 2,2-bis[4-hydroxyphenyl]propane, mono- or diglycidyl ether or diglycidyl carboxylate, polyalkylene oxide diglycol, vegetable oils, epoxy resin, polyaminoamide and optionally mineral or organic fillers. The compositions are used, for example, for adhesive bonding or for sealing expansion joints.
Patent IT-1242427-B (IT)
Title: Insole fitted with a metatarsal insert made of soft leather
Inventor: FORTUNA ALFONSO
IPC: A43D/
Filed: 1990-12-14
Granted: 1994-03-04
Abstract: The present invention relates to an insole which has, in the region of its metatarsal area, an insert consisting of a transverse strip of a soft and flexible material, the transverse edges of which are superimposed, glued and stitched to the corresponding ones of the insole. <IMAGE>
Patent NO-141511-B (NO)
Title: Emballasjematerialbane for fremstilling av beholdere
Inventor: RAUSING RUBEN
IPC: B31B1/90
Filed: 1973-03-13
Abstract: Emballasjematerialbane for fremstilling av beholdere.
Patent RS-49955-B (RS)
Title: Stabile compositions comprising levosimendan and alginic acid
Inventor: BACKMAN MAARIT
IPC: A61K9/16
Filed: 1999-04-23
Abstract: The present invention relates to pharmaceutical compositions of levosimendan comprising alginic acid for improving the stability of levosimendan in the compositions. Levosimendan is useful in the treatment of congestive heart failure.
Patent YU-47479-B (YU)
Title: Uredjaj za toplotno razlaganje tečnih škodljivih materijala
Inventor: BUZETZKI E
IPC: F23J15/00
Filed: 1989-04-06
Abstract: UREDJAJ ZA TOPLOTNO RAZLAGANJE TEČNIH ŠKODLJIVIH MATERIJALA, naročito dioksina i furana, sa cilindričnom komorom (1) sagorevanja i iznad nje postavljenom komorom (15) za naknadno sagorevanje, pri čemu komora (1) za sagorevanje ima najmanje jedan ulazni otvor (3) za gas napunjen škodljivim materijalom, naročito za dimni gas, i najmanje jedan gorionik (4) usmeren u komori (1) sagorevanja, dok je iznad gorionika (4) postavljen uredjaj (20) za zadržavanje, koji je izveden u vidu prstenastog tela sa središnjim protočnimm otvorom (7), čiji je prečnik manji od prečnika komore sagorevanja, i koji ima mlaznice (10a, 10b) usmerene koso na dole, naznačen time, što je ulazni otvor (3) za gas napunjen škodljivim materijalom postavljen ispod gorionika (4), pri čemu se kroz mlaznice (10a, 10b) uredjaja (20) za gorionika (4), pri čemu se kroz mlaznice (10a, 10b) uredjaja (20) za zadržavanje uvodi sekundarni vazduh, i što uredjaj (20) za zadržavanje ima otvore (9) rasporedjena oko središnjeg protočnog otvora (7). Prijava sadrži još 14 zavisnih zahteva.
Patent ZA-95590-B (ZA)
Title: Zirconium silicate grinding medium
Inventor: BROWNBRIDGE THOMAS IAN
IPC: B02C23/36
Filed: 1995-01-25
Abstract: A grinding medium including naturally occurring zirconium silicate sand characterized by a density in the range of from about 4g/cc absolute to about 6g/cc absolute is provided. Also provided is a method for milling a powder which includes steps of forming a milling slurry including a naturally occurring zirconium silicate sand grinding medium having a density in the range of from about 4g/cc absolute to about 6g/cc absolute.
Patent AT-408345-B (AT)
Inventor: SCHMITT THEODORE NICOLAS DR
IPC: C04B37/02
Filed: 1999-11-17
Granted: 2001-10-25
Abstract: The invention relates to a method for attaching a first body which is of one of a metal matrix composite (MMC)-material or copper to a second body which is a ceramic member for acting as a heat sink, wherein the surface of the ceramic member which is placed against the MMC- or copper body is coated with a first metal by heating the two bodies to above the eutectic temperature of a system comprised of the matrix metal of the MMC-body or the copper of the copper body and the first metal applied to the surface of the ceramic member; and subsequently cooling the system to room temperature.
Patent AT-396549-B (AT)
Title: Water-treading therapeutic device for laying in a water- filled container
IPC: A63B21/008
Filed: 1991-12-16
Granted: 1993-10-25
Abstract: The hydrotherapeutic device for laying in a water-filled container, simultaneously serving as a foot bubble spa and reflexology treatment device, comprises a bellows (a) made of elastic material such as rubber or plastic, the underside being provided with suction cups (f) and the upper side with studs (b) over the whole surface and air outlets (c) and a non-return valve (d) with air hose (e). <IMAGE>
Patent AT-385887-B (AT)
Title: Guide for withdrawable furniture parts
Inventor: FULTERER MANFRED
IPC: A47B88/04
Filed: 1983-08-03
Granted: 1988-05-25
Abstract: During the installation of guides for withdrawable furniture parts, having at least one running rail 1 that can be fixed to a furniture side wall and a furniture rail 6 which can be fixed to a withdrawable furniture part, mounting errors cannot reliably be avoided. Such errors and likewise deficiencies in the guide itself not only influence the easy running of the guide but also manifest themselves visually. In order to correct them simply, in a guide of this type which has a stationary, freely rotatable roller 3 at least at the front end of the running rail, on which the running track 9 of the furniture rail 6 rests, provision is made for the end 10 of the running track of the furniture rail to project out freely and to carry a screw 12 which is arranged with its axis at right angles to the running track and which is rotatably anchored in a lug 15 connected to a web 7 adjoining the running track on the furniture rail. If the screw is rotated, then the distance of the freely projecting end 10 of the running track can be changed with respect to this lug, by which means the desired vertical correction can be achieved. <IMAGE>
Patent AT-382359-B (AT)
Title: Press device for producing shaped parts from glass, ceramic or plastic
IPC: B29C/
Filed: 1979-08-07
Granted: 1987-02-25
Abstract: Press device for producing shaped parts from glass, ceramic or plastic, having an upper ram 30 and a lower ram 46, of which the end faces which face one another are designed as shaping-chamber surfaces 58, 60, and having a stripper ring 18, which can be displaced on one 30 of the rams 30, 46, the stripper ring 18 being arranged in a stationary position, and the lower ram 46, in the feed position, projecting upwards through the stripper ring, in that the common parting plane of the two rams 30, 46 in the pressing position lies above the stripper ring 18, in that the rams 30, 46 are designed to move jointly into a stripping position, in which the parting plane of the rams passes through the stripper ring 18, and in that the pressed blank, in the eject position of the press device, lies at a lower level than in the pressing position, and the lower ram 46 is recessed into a low position below the removal conveyor belt. <IMAGE>
Patent CH-641624-B (CH)
Inventor: HENRI GIRARD
IPC: G04B37/06
Filed: 1981-04-24
Abstract: The timepiece comprises in particular an electronic module (1) with mechanism for unlocking an operating stem of the type with setting lever, which can be manoeuvred by way of a setting-lever screw (2) which is accessible through the lower face of the module. The case of the piece has an aperture closed by a cover (5) for installing a battery (3). In order to allow access to the setting-lever screw (2) via the aperture, the latter extends at least as far as the level of the screw. <IMAGE>
Patent DK-151968-B (DK)
Inventor: HEAVNER GEORGE
IPC: C07K/
Filed: 1981-06-16
Abstract: Solution phase methods and compositions for preparing H-ARG-X-Z-Y-TYR-R wherein X is LYS and Y is VAL or X and Y are both SAR, Z is ASP or GLU, and R is NH<sub>2</sub> or OH.
Patent DK-166329-B (DK)
Inventor: ERREN KARL-HEINZ
IPC: D01D5/16
Filed: 1985-09-26
Abstract: A method of producing a flat polymeric yarn is disclosed which includes the steps of melt spinning a polymer to form a plurality of running filaments, combining the filaments to form a running bundle of filaments, and then guiding the running bundle into contact with a ribbon of fluid so as to apply a controlled quantity of the fluid to the bundle. The fluid coated bundle is guided over a plurality of serially arranged curved braking surfaces, and it is then withdrawn by means of a draw roll so as to draw the running bundle to an extent which exceeds its plastic limit. The application of the fluid to the bundle in accordance with the present invention results in a hydrodynamic friction, rather than a sliding contact friction, between the bundle and braking surfaces, and produces yarn of very uniform quality while also avoiding wear of the braking surfaces.
Patent DK-153954-B (DK)
Inventor: KUNG PATRICK CHUNG-SHU
IPC: G01N33/50
Filed: 1980-12-03
Abstract: Hybrid cell line for production of monoclonal antibody to an antigen found on approximately 95% of normal human thymocytes. The hybrid is formed by fusing splenocytes from immunized CAF, mice with P3X63Ag8U1 myeloma cells. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
Patent FI-77463-B (FI)
Inventor: NEDELEC LUCIEN
IPC: C07J51/00
Filed: 1981-12-21
Granted: 1988-11-30
Abstract: Novel steroids of the formula    <IMAGE>  I'  wherein R is selected from the group consisting of R1 and R2, R1 is selected from the group consisting of alkyl of 1 to 8 carbon atoms and alkenyl and alkynyl of 2 to 8 carbon atoms R2 is -(CH2)n-R3, n is an integer from 1 to 8 and R3 is selected from the group consisting of free or protected -OH, free or protected -NH2, monoalkyl and dialkylamino with 1 to 6 carbon atoms, a free, esterified or salified -COOH and halogen X and Y together form   <IMAGE>  or X is OH and Y is -CH2-CH2-COOM, M is selected from the group consisting of hydrogen, an alkali metal and -NH4, Ra is selected from the group consisting of hydrogen and methyl, the dotted line in the I(2)-position indicates the optional presence of a double bond and the wavy line indicates that R may be in the  alpha - or  beta -position, with the proviso that R is not R1 or R2 when n is 1 and R3 is halogen, when the 1(2) bond is a simple bond and when Ra is -CH3, R3 is not a free carboxyl when Y is -CH2-CH2-COOM in which M is an alkali metal or -NH4 and R3  is not a salified carboxyl when Y is -CH2-CH2-COOH having aldosterone antagonistic properties and increases aqueous sodium diuresis while conserving organic potassium without secondary hormonal effects and their preparation.
Patent FI-71603-B (FI)
Inventor: LUND ANDERS E
IPC: E04C3/36
Filed: 1982-02-26
Granted: 1986-10-10
Abstract: An elongate structural member has a longitudinal axis and is comprised of a plurality of elongate panels having lateral edges, the panels being arranged to form an elongate central cavity with lateral edges of adjacent panels being fixediy joined together. The elongate panels are each comprised of a plurality of wood particles intermixed with a suitable binder and compressed to form a densified product. A rigid foam material is provided filling at least a portion of the elongate central cavity for reinforcing the elongate structure, the rigid foam material also being bonded to the inwardly facing surfaces to further reinforce the elongate structure.
Patent FI-73904-B (FI)
Inventor: LEBOEUF WILLIAM EDGAR
IPC: B26D5/02
Filed: 1982-09-22
Granted: 1987-08-31
Abstract: An apparatus for longitudinally slitting moving webs of material. The apparatus provides for adjustment of cutting blade engagement with a moving web during slitting. The apparatus also provides for a consistent blade cutting angle as well as for increased use of a blade cutting edge. Further, the apparatus markedly reduces operator exposure to blade cutting edges.
Patent FI-78149-B (FI)
Title: Separation system and process for the manufacture of a separator
Inventor: KOSKINEN ESA
IPC: E03F/
Filed: 1987-09-18
Granted: 1989-02-28
Abstract: The separation system is intended especially for sand, grease separators. Each separator has a service well (1) and a container for the separated material (2). The system consists of basic parts such as a service well part (3) as well as of at least one additional part (6, 7), or optional part. According to the system, at least a series of separators are to be manufactured such that the basic parts (3-5) of the smallest of the series' separators are interconnected, and the larger separators feature additional parts (6,7) connected to the basic parts (3-5) such that the additional part/parts (6,7) are located between the service well part (3) and the connecting ring part (4), and/or between the connecting ring part (4) and the bottom part (5).<IMAGE>