Patent SG-11201810149V-A (SG)
Title: Anti hla-g specific antibodies
Inventor: LANGLADE DEMOYEN PIERRE
IPC: C07K16/28
Filed: 2017-06-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111H111011111111111111111111111111001010H0111111111111H1110111111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2017/207775 Al 07 December 2017 (07.12.2017) WIP0 I PCT (51) International Patent Classification: C07K 16/28 (2006.01) C07K 7/08 (2006.01) Published: — with international search report (Art. 21(3)) (21) International Application Number: — with sequence listing part of description (Rule 5.2(a)) PCT/EP2017/063503 (22) International Filing Date: 02 June 2017 (02.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16305650.0 03 June 2016 (03.06.2016) EP (71) Applicant: INVECTYS [FR/FR]; 28, me du Docteur Roux, 75015 PARIS (FR). (72) Inventors: LANGLADE DEMOYEN, Pierre; 1, place de Bagatelle, 92200 Neuilly-sur-Seine (FR). HUET, Thierry; 21-23, me Lequesne, 94130 Nogent sur Mame (FR). CAU- MARTIN, Julien; 14, place du Marche, 78110 Le Vesinet _ (FR). LOUSTAU, Maria; 15, rue Chaptal, 75009 Paris (FR). WEHBE, Maria; 1, mail des Thuyas, 78180 Mon- tigny-le-Bretonneux (FR). = Agent: CABINET BECKER ET ASSOCIES; 25, rue = (74) Louis le Grand, 75002 PARIS (FR). = Designated States (unless otherwise indicated, for every (81) kind of national protection available): AE, AG, AL, AM, _ AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, = = = MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, = PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, = = SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, = TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = = Designated States (unless otherwise indicated, for every (84) = kind of regional protection available): ARIPO (BW, GH, = GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, — EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). = — 1-1 in IN (54) Title: ANTI HLA-G SPECIFIC ANTIBODIES IN 0 (57) : The present invention relates to antibodies, or antigen-binding fragments thereof, directed against human leukocyte ei ----. antigen-G (HLA- G) protein and raised against an immunogenic peptide derived from the a3 domain of HLA-G protein. The invention IN , 1 further relates to the immunogenic peptide, and methods for producing said anti-HLA-G specific antibodies. A particular embodiment © refers to the monoclonal antibody with the arbitrary designation 15E7 for which the sequence is provided. Also a anti-HLA-G sin- el gle-chain antibody gene library was generated and six specific binders were identified from that library. O