Patent SG-11201908790P-A (SG)
Title: Glucocorticoid receptor modulators to treat cervical cancer
Inventor: HUNT HAZEL
IPC: A61K45/06
Filed: 2018-03-30
Abstract: GroupPaclitaxel Vehicle+. COM - 125134 Vehicle Grcrop.2.: 7.5regjkg Group 7,5rng/kg CORT12.5134 3 tinvikg Group 4: ?act.4 . a>,.... 15/lig/kg Girmp Paclitaxel 15rnsil CORT12.51343Ornag 1C0 10 15 20 40 45 55 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I PCT mu °million °nolo HE mil o1 mo Ho Imo oimIE (10) International Publication Number WO 2018/183947 Al (51) International Patent Classification: A61K 31/337 (2006.01) A61K 31/4745 (2006.01) A61K 31/513 (2006.01) A61K 45/06 (2006.01) A61K 31/7068 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/US2018/025547 (22) International Filing Date: 30 March 2018 (30.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/480,226 31 March 2017 (31.03.2017) US (71) Applicant: CORCEPT THERAPEUTICS, INC. [US/US]; 149 Commonwealth Drive, Menlo Park, Califor- nia 94025 (US). (72) Inventor: HUNT, Hazel; 149 Commonwealth Drive, Men- lo Park, California 94025 (US). (74) Agent: MAO, Yifan et al.; KILPATRICK TOWNSEND & STOCKTON LLP, Mailstop: IP Docketing - 22, 1100 Peachtree Street, Suite 2800, Atlanta, Georgia 30309 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: GLUCOCORTICOID RECEPTOR MODULATORS TO TREAT CERVICAL CANCER 1-1 N co 00 O C FIG. 1 (57) : Methods for treating a subject having a cancerous tumor are disclosed. The methods comprise administering to the subject an effective amount of a non-steroidal selective glucocorticoid receptor modulator (SGRM) and an effective amount of a chemothera- peutic agent. The tumor may be cervical cancer. The SGRM may be a fused azadecalin. In embodiments, the SGRM may be a heteroaryl ketone fused azadecalin or an octahydro fused azadecalin. [Continued on next page] WO 2018/183947 Al OII TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))