baber/WOPTO huggingface dataset:
Patent RU-2764116-C2 (RU)
Inventor: BOUABOULA MONSIF
IPC: A61K31/40
Filed: 2018-07-23
Granted: 2022-01-13
Abstract: Группа изобретений относится к области медицины, а именно к комбинации для лечения рака молочной железы, содержащей 6-(2,4-дихлорфенил)-5-[4-[(3S)-1-(3-фторпропил)пирролидин-3-ил]оксифенил]-8,9-дигидро-7H-бензо[7]аннулен-2-карбоновую кислоту или ее фармацевтически приемлемую соль и палбоциклиб, а также к фармацевтической композиции для лечения рака молочной железы, содержащей 6-(2,4-дихлорфенил)-5-[4-[(3S)-1-(3-фторпропил)пирролидин-3-ил]оксифенил]-8,9-дигидро-7H-бензо[7]аннулен-2-карбоновую кислоту или ее фармацевтически приемлемую соль и палбоциклиб и по меньшей мере одно фармацевтически приемлемое вспомогательное вещество, также относится к применению 6-(2,4-дихлорфенил)-5-[4-[(3S)-1-(3-фторпропил)пирролидин-3-ил]оксифенил]-8,9-дигидро-7H-бензо[7]аннулен-2-карбоновой кислоты или ее фармацевтически приемлемой соли, осуществляемому путем совместного введения с палбоциклибом для лечения рака молочной железы, и к применению палбоциклиба,  осуществляемому путем совместного введения с 6-(2,4-дихлорфенил)-5-[4-[(3S)-1-(3-фторпропил)пирролидин-3-ил]оксифенил]-8,9-дигидро-7H-бензо[7]аннулен-2-карбоновой кислотой или ее фармацевтически приемлемой солью для лечения рака молочной железы, и также относится к фармацевтическому набору для лечения рака молочной железы, содержащему: (i) первую фармацевтическую композицию, содержащую 6-(2,4-дихлорфенил)-5-[4-[(3S)-1-(3-фторпропил)пирролидин-3-ил]оксифенил]-8,9-дигидро-7H-бензо[7]аннулен-2-карбоновую кислоту или ее фармацевтически приемлемую соль и по меньшей мере одно фармацевтически приемлемое вспомогательное вещество; (ii) вторую фармацевтическую композицию, содержащую палбоциклиб и по меньшей мере одно фармацевтически приемлемое вспомогательное вещество; при этом обе фармацевтические композиции (i) и (ii) находятся в отдельных камерах и предназначены для независимого друг от друга введения, при этом каждое введение в отношении другого является одновременным, раздельным или распределенным во времени. Группа изобретений обеспечивает разработку комбинации 6-(2,4-дихлорфенил)-5-[4-[(3S)-1-(3- фторпропил)пирролидин-3-ил]оксифенил]-8,9-дигидро-7H-бензо[7]аннулен-2-карбоновой кислоты с палбоциклибом, которая хорошо переносится, демонстрирует высокую противоопухолевую эффективность и вызывает регрессию опухоли с синергетическим эффектом по сравнению с каждым активным ингредиентом в отдельности. 5 н. и 5 з.п. ф-лы, 3 табл., 2 пр., 3 ил.
Patent RU-2763229-C2 (RU)
Title: Device and method for manufacturing packages with welded seam along perimeter
Inventor: SCHUMANN KLAUS
IPC: B32B37/14
Filed: 2018-07-21
Granted: 2021-12-28
Abstract: FIELD: packaging. 
     SUBSTANCE: invention relates to a method for manufacturing a package with a welded seam along the perimeter with layered composite placed in it, to a device for manufacturing a package with a welded seam along the perimeter using the specified method, as well as to a package with a welded seam along the perimeter manufactured by the specified method. A method for manufacturing package (160) with a welded seam along the perimeter with layered composite (141) placed in it, device (10) for manufacturing packages with a welded seam along the perimeter using the specified method, as well as package (160) manufactured by the specified method are claimed. Layered composite is separated from web (140) consisting of layered composites, which includes film substrate (110) with substrates (130) placed on it, which are respectively covered with covering film (136). Intermediate body (165) is brought to the web of layered composites or to layered composite, or intermediate body (165) is formed in film substrate, wherein intermediate bodies(y) at least locally surround(s) all free substrate surfaces (133). Layered composite (141) and all intermediate bodies are inserted between two webs (61, 62) of packaging material. Webs of packaging material are welded to each other. Finally, packages (160) with a welded seam along the perimeter are separated. 
     EFFECT: specified method and device are developed for the automated manufacture of packages with a welded seam along the perimeter described in the claim. 
     10 cl, 19 dwg
Patent RU-2771311-C2 (RU)
Title: Ингибитор fgfr и его медицинское применение
Inventor: WANG YIKAI
IPC: A61P35/00
Filed: 2018-08-15
Granted: 2022-04-29
Abstract: Изобретение относится к гетероароматическим соединениям. Предложено соединение формулы (I) или его фармацевтически приемлемая соль, где L выбран из С 2-4 алкенила, C 2-4 алкинила и R 5 , который представляет собой H или выбран из C 1-3 алкила, C 1-3 гетероалкила, C 3-6 циклоалкила и 4-6-членного гетероциклоалкила, которые необязательно замещены 1, 2 или 3 R группами; или R 5  и L вместе образуют структурную единицу  , которая представляет собой  ; R 1  выбран из H, галогена, OH и NH 2  или выбран из C 1-3 алкила и C 1-3 гетероалкила; R 2  выбран из H, F, Cl, Br, I, OH и NH 2 ; R 3  выбран из H, галогена, OH, NH 2  и CN или выбран из C 1-3 алкила и C 1-3 гетероалкила; R 4  выбран из H, галогена, OH, NH 2  и CN или выбран из C 1-3 алкила и C 1-3 гетероалкила, которые необязательно замещены 1R группой; R 6  выбран из H, галогена, OH и NH 2  или выбран из C 1-3 алкила; гетероатом или гетерогруппа независимо и отдельно выбраны из -NH-, N, -O- и -S- в количестве 1, 2 или 3. Также раскрываются конкретные соединения и применения соединений. Технический результат – получение соединений, подходящих для использования в качестве FGFR ингибитора. 4 н. и 15 з.п. ф-лы,  6 табл., 44 пр.
Patent UA-50331-C2 (UA)
Title: Method for treating osteoporosis in rheumatologic patients
Inventor: BOHATYRIOVA TETIANA VIKTORIVNA
IPC: A61K35/08
Filed: 2001-12-21
Abstract: The invention relates to the medicine and may be used for treating osteoporosis in the rheumatologic patients. The treatment course provides for drinking daily the mineral water with calcium content at least 200 mg/L followed by hydrolaser shower equipped with helium-neon laser at 632.8 nm and the output of 25-30 mW. The following regions are treated: epigastral area, the areas of the liver, the kidneys, the affected joints, and/or the backbone. Each session, the duration of the procedure and the temperature of the water increase relative to the previous ones. The hydrolaser shower is followed by the ultrasound reflex therapy at 22 kHz. The acupuncture points specific of the liver, the kidneys, the stomach, the intestine, the joints, and/or the backbone are involved. The areas of the lymphatic nodes is exposed to the ultrasound at 24 kHz. The overall duration of the treatment is 24 days.
Patent UA-51184-C2 (UA)
Title: Strainer of belt conveyor
Inventor: OSYPENKO ANATOLII VASYLIOVYCH
IPC: B65G23/44
Filed: 2002-01-28
Abstract: The strainer of a belt conveyor contains a frame with a snub pulley, a tension winch, the supports of the frame in the form of two posts and upper and lower transverse links mounted on the ground of mine working and connected between them with the help of longitudinal guides and with the frame of snub pulley û with the help of links. The carriage with tension reel is mounted on the guides with the help of four rollers and is connected with the rope of tension winch. Hollow branch of the conveyor belt on the area between driving unit and linear section of conveyor consecutively bends round the snub pulley and tension reel. The guides are fastened to the posts of supports and upper transverse link is located at the base of support. The guides are made in the form of a box and the rollers have the ledges from internal side.
Patent UA-74561-C2 (UA)
Title: A stamp paint
Inventor: ANDROPOV VOLODYMYR IVANOVYCH
IPC: C09D11/18
Filed: 2002-05-28
Abstract: A stamp paint with reflections shining in UV-rays, which contains corn or potato dextrin, day fluorescent pigments, NF dispersant, diethylene glycol or ethylene glycol, water-soluble dye, ethyl alcohol, luminophor and water.
Patent UA-76115-C2 (UA)
Title: Early diagnostics of conformational diseases
IPC: G01N29/00
Filed: 2001-06-13
Abstract: A method for the diagnosis or detection of conformational diseases by assaying for a marker (the pathogenic conformer) of such diseases in a sample is described, which method comprises a cyclic amplification system to increase the levels of the pathogenic conformer which causes such diseases. In particular, such transmissible conformational diseases may be prion encephalopathies. Assays, diagnostic kits and apparatus based on such methods are also disclosed.
Patent UA-66669-C2 (UA)
Title: A composition for the prevention of acid microbiological corrosion of water , a method for water treatment and a method for utilization of industrial waters containing ammonium nitrogen
Inventor: IVONIN MYKHAILO VOLODYMYROVYCH
IPC: C02F5/08
Filed: 2003-09-08
Abstract: A composition for the prevention of acid microbiological corrosion of water involves inhibitor of nitrification and organic complexing agent. A method for water treatment to prevent acid microbiological corrosion involves dosage of acid microbiological corrosion inhibitor into the water. A method for utilization of industrial waters which contain ammonium nitrogen by use thereof as additional water for the inflow of reverse water supply systems.
Patent UA-82311-C2 (UA)
Title: Method for digital coding of money plastic cards
Inventor: PEREVERZIEV VIKTOR HENNADIIOVYCH
IPC: G06K9/00
Filed: 2004-03-09
Abstract: Method for digital coding of money plastic cards relates to methods for protection of plastic credit cards against falsification. The method includes scanning of imprint of user’s finger. Scanned pattern is applied to matrix with formation of number of cells being stored depending on dimension of imprint in such way that information is stored only to cells through which line of imprint goes, or vice versa. After that pattern with matrix is cut through not separated. In each part one stores digital information in matrix cells being written. One reads information in each line. One forms and writes to card control number. After that one part of matrix is written on card and the other one – to payment system. Technical result is in increase of protection of plastic credit cards against falsification.
Patent UA-86750-C2 (UA)
Title: Use of il-1f7b, able to bind il-18r and il-18bp, with il-18bp for the treatment of diseases associated with excessive il-18activity
Inventor: DINARELLO CHARLES A
IPC: A61K38/17
Filed: 2003-10-03
Abstract: The present invention relates to the use of a cytokine-1, preferably from the IL-1 family more preferably IL-lF7b, or an isoform, mutein, fused protein, functional derivative or fragment thereof, capable of binding to IL-18BP or a mutein, fused protein, functional derivative or fragment thereof and capable of inhibiting a receptor of a cytokine-2, cytokine-2 being a member of the IL-1 family, preferably IL-18, in the manufacture of a medicament for the treatment or prevention of a disease which is caused or aggravated by inducing said receptor of cytokine-2.
Patent UA-79478-C2 (UA)
Title: Wound-healing composition and method for its production
Inventor: HERASCHENKO IHOR IVANOVYCH
IPC: A61P17/02
Filed: 2005-01-21
Abstract: The wound-healing powder composition comprises polymethyl siloxan, the superfine silicon dioxide, and miramistine. Due to the balance of the hydrophilic and hydrophobic properties, the composition possessed the wide range of the absorption capacity allowing for the absorption of the toxic wound metabolites such as proteins, polypeptides, bacterial enzymes, antigens, medium- and low molecular substances, and other decay products. Miramistine provides for moistening hydrophobic polymethyl siloxan. At the same time, Miramistine is antibacterial agent. The composition possesses the sufficient osmotic capacity allowing for the rapid elimination of edema. The composition is intended for treating the infected surgical wounds in the first stage of the wound evolution (postoperative suppuration, phlegmons, abscesses, furuncles, etc.) and for treating the bedsores and the trophic ulcers.
Patent UA-77905-C2 (UA)
Title: Device for determining strength of concrete
Inventor: VOLKOV LEONID PETROVYCH
IPC: G01N33/38
Filed: 2005-09-29
Abstract: The proposed device for determining strength of concrete contains a hydraulic cylinder, pressure transducers, a thrust rod with a shank, and inserts that cover the thrust rod. To prevent the bending of the thrust rod, the rod contains two sections, each of which is shaped as a truncated tetrahedral pyramid. The imaginary vertex of each pyramid is directed to the shank of the thrust rod. The length of the side of the pyramid exceeds the thrust rod diameter. Each insert has two sloped surfaces. The angle of slope of each surface corresponds to the angle of slope of the side of the pyramid.
Patent UA-82724-C2 (UA)
Title: Fixation frame for underground drift
Inventor: PIECZYK GREGOR
IPC: E21D23/00
Filed: 2006-04-27
Abstract: The invention relates to fixation of underground workings, Fixation frame has slides, roof bar and hydraulic standpipes placed between the slides and the roof bar. Roof bar consists of two long elements. Each element of roof bar is supported freely with at least one standpipe installed on single slides. The invention provides more uniform distribution of forces from roof bar to roof, in particular, inclined one, of working.
Patent UA-81569-C2 (UA)
Title: Die cavity and die for continuously casting billets, blooms and blanks
Inventor: ROEHRIG ADALBERT
IPC: B22D11/00
Filed: 2004-12-11
Abstract: The invention relates to a die cavity of a casting die for continuously casting billets, blooms and blanks, steel being cast in a die cavity having a cross-section with a partially curved peripheral (42) line, and cavity walls cooled. The aim of the invention is to create optimum conditions for a regular heat exchange between a forming strand shell and the die cavity wall along the peripheral line (42) of the strand cross-section, and to avoid solidification defects in the strand shell. To this end, the degree of curvature 1/R is reduced at least on part of the curved peripheral line (42) of the comer regions from peripheral lines (42', 42") of the same corner regions, that are successive in the casting direction, and at least over part of the length of the die, in the concave corner regions of the die cavity, in order to control the targeted closure of the gap between the strand shell and the cooled die cavity, or a targeted strand shell deformation.
Patent UA-87130-C2 (UA)
Title: Optical device and method to check inclination of container
Inventor: JUVINOL JOHN U
IPC: G01B11/26
Filed: 2005-01-25
Abstract: Device for control of inclination of container (34) has light source (50) that is placed lower than container (34) and serves for light supply to bottom of container (62) at that as container is held in initial position and is rotated with respect to axis (A). Light-sensitive indicator (54) placed lower than container (34) obtains part of light from source (50) reflected from bottom of container (62). Processor for data processing (56) is connected to light-sensitive indicator (54) for determination of separation of bottom of container (62) from plane normal to axis (A) as joint function of parameters of reflected light and position of container. Container (34) is best variant is held in initial position and rotates with respect to axis by means of drive roller (24) that holds container (34) in front of additional rollers (26, 28) placed in axial position in such way that one can determine middle axis of rotation as function of geometry of container (34) and distance between additional rollers (26, 28).
Patent UA-89491-C2 (UA)
Title: SAPPHIRE single crystal AND METHOD for ITS producing
Inventor: LOCHER JOHN WOLTER
IPC: C30B29/20
Filed: 2005-06-04
Abstract: Various single crystals are disclosed including sapphire. The single crystals have desirable geometric properties, including a width not less than about and the thickness is not less than about . The single crystal may also have other features, such as maximum thickness variation, and as-formed crystals may have a generally symmetrical neck portion, particularly related to the transition from the neck to the main body of the crystal. Methods and for forming such crystals and an apparatus for carrying out the methods are disclosed as well.
Patent UA-88480-C2 (UA)
Title: Method for evaluation of oil-plant raw material
Inventor: BATLER GRAHAM
IPC: G01N33/26
Filed: 2005-09-14
Abstract: A process for evaluating a refinery feedstock, said process comprising: (i) providing a refinery feedstock, (ii) treating said refinery feedstock to produce an array comprising a plurality of fractions having different chemical and/or physical properties, each fraction being representative of a process stream that might be present in a refinery, and (iii) analysing each of said plurality of fractions to determine one or more chemical and/or physical properties of the fractions, said analyses being performed at least partially in parallel. In a preferred embodiment, a plurality of refinery feedstocks is evaluated, each being fractionated prior to analysis of the fractions.
Patent UA-83320-C2 (UA)
Title: Lozenge, comprising octenidine and intended for treatment of inflammatory oral and pharyngeal diseases
Inventor: MIETHING HODGER
IPC: A61P1/02
Filed: 2005-08-19
Abstract: The invention relates to a lozenge, especially based on caramel, which is suitable for the topical treatment of inflammatory oral and pharyngeal diseases. Said lozenge contains octenidine, preferably in the form of octenidine dihydrochloride, as an active substance such that a therapeutically effective amount of octenidine, preferably octenidine dihydrochloride, is released during sucking when the lozenge is administered and sucked in a patient's oral and pharyngeal cavity.
Patent UA-91697-C2 (UA)
Title: 3, 5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED-3H-OXAZOLO AND 3H-THIAZOLO [4,5-d]PYRIMIDIN-2-ONE COMPOUNDS AND PRODRUGS THEREOF
Inventor: WEBBER STEPHEN E
IPC: C07D495/04
Filed: 2005-12-16
Abstract: The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3-H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and pharmaceutical compositions containing them, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds and prodrugs.
Patent UA-83974-C2 (UA)
Title: Method for obtaining ferrotitanium ingot by electroarc melting of rutile under layer of protective flux
Inventor: CHEPEL SERHII MYKOLAIOVYCH
IPC: C22B34/10
Filed: 2007-10-11
Abstract: The invention relates to non-ferrous metallurgy, namely to a method for obtaining of ferrotitanium ingot by arc-jet melting of rutile under layer of protective flux. A method comprises production of consumable electrode by forming and compacting of charge in steel casing, containing rutile, aluminium grit and binding agent – liquid glass. The melting of the consumable electrode under layer coating slag is carried out and ferrotitanium smelt is obtained. The consumable electrode is dried before the supply, in parallel flux is melted by non-consumable graphite electrode. Lime is supplied continuously from batching plant into a bath casting mold. The invention provides increasing of quality of the consumable electrode and ferrotitanium ingot, automation of process for preparation and melting of the consumable electrode.
Patent UA-95080-C2 (UA)
Title: Actuator position control device using a fail freeze servo-valve
Inventor: MARLI PASCAL
IPC: F15B9/03
Filed: 2008-03-20
Abstract: The actuator (50) comprises a slide (52) carrying at least two stages (54, 56) and being capable of sliding in a cylinder and two control chambers (62, 64) connected to respective use holes (U1, U2) of an electrically controlled servo-valve hydraulic distributor (20). The control chambers (62, 64) are each situated on one side of a respective stage and an intermediate chamber connected to high or low pressure is situated between the other sides of the stages. In the event of electrical control failure, the distributor (20) slide is taken to a safety position in which the control chambers (62, 64) of the actuator (50) are at the same low or high pressure opposed to that applying in the intermediate chamber (66) so that each stage of the actuator slide is then subjected to high pressure on one side and to low pressure on the other side. Sealing between each actuator slide stage (54, 56) and the actuator cylinder (60) is carried out by a dynamic seal (70) producing a frictional force between stage and cylinder, depending on the difference between the pressures exerted on the two sides of the stage so that, in the event of electrical control failure, the actuator slide valve is immobilized in its position at the moment of the failure ("fail freeze"). The actuator (50) can be an aeronautical engine fuel metering unit.
Patent UA-90384-C2 (UA)
Title: method for changing and transporting rolls
Inventor: BLECHER GERHARD
IPC: B21B31/00
Filed: 2007-01-09
Abstract: The invention relates to a method for changing/transporting a first roll set (7, 8) and a second roll set (22) on a transversal displacement platform (23) in the region of a roll stand (4) in a roll hall, in or counter to the direction of rolling. During the changing/transporting of the first and the second roll set (7, 8, 22) by the transversal displacement platform (23), a roll changing hole (10) is completely trans versed/covered. The invention also relates to a device for carrying out said method.
Patent UA-91479-C2 (UA)
Title: Method for investigation of structure and element composition of substance and device for its realization
Inventor: STORIZHKO VOLODYMYR YUKHYMOVYCH
IPC: G01N23/00
Filed: 2009-11-16
Abstract: The invention relates to investigation of structure and element composition of substances at which one directs beam of accelerated protons to target made of substance under investigation, with registration of characteristic X-ray radiation that is generated as result of interaction of beam of accelerated protons and target, after that signal undergoes amplification with following processing for transformation to digital sequence and data on useful signal are transferred to computer, at that amplification of signal is performed in two steps and simultaneously with registration of characteristic X-ray radiation one registers energy of protons that cause that characteristic radiation, the signal is amplified as well, after that one forms both signals in same form and amplitude, additionally after second amplification signal from detector of characteristic X-ray radiation before processing for following transformation to digital sequence simultaneously with formation of service signal is directed for delay, at that signal of characteristic X-ray radiation and signal of energy of protons are analyzed on coincidence in time of those. Besides that the invention relates to device for implementation of the method.
Patent UA-99189-C2 (UA)
Title: Method for production of color magnetic dactyloscopic powders
Inventor: ALIOKHOV YURII OLEKSANDROVYCH
IPC: G01N27/84
Filed: 2010-10-25
Abstract: The invention relates to the production of color magnetic powders for dactyloscopic studies. A method for the production of color magnetic dactyloscopic powders includes milling and mixing powders of color pigment – oxides of metals and iron – with solution of stearic acid in acetone. According to the invention mixing of solution of stearic acid in acetone with concentration 35-55 wt. %, and powders of color pigments is carried out in hermetic volume of ball vibro-mill. Use of the invention makes it possible, at keeping high quality of dactyloscopic powders obtained, to decrease labor intensity of the production process, to decrease its duration.