baber/WOPTO huggingface dataset:
Patent JP-2002513411-A (JP)
Title: 高いバイオアベイラビリティを有するルテインエステル
IPC: A61P39/06
Filed: 1998-04-03
Abstract: (57)【要約】
本発明は、ルテインエステルを含有し実質的にルテインを含まない抗酸化カロチノイド組成物を提供するものである。この抗酸化組成物は、フリーラジカルの有害な影響から守るためにヒトに投与される製品に容易に配合することができる。本発明はまた、ルテインエステルを含有し実質的にルテインを含まない抗酸化カロチノイド組成物の効果量を投与することにより、フリーラジカルの有害な影響を防ぐ又は抑制する方法を提供するものである。
Patent JP-2001519663-A (JP)
Title: 遺伝子導入ジカンバ−分解生物体を製造及び使用するための方法及び材料
IPC: C12N15/29
Filed: 1998-04-03
Abstract: (57)【要約】
この発明は単離し、及び少なくとも部分的に精製したジカンバ−分解酵素、ジカンバ−分解酵素の遺伝暗号を指定する単離ＤＮＡ分子、ジカンバ−分解酵素の遺伝暗号を指定するＤＮＡ構成、ジカンバ−分解酵素の遺伝暗号を指定するＤＮＡを含む遺伝子導入宿主細胞、ジカンバ−分解酵素の遺伝暗号を指定するＤＮＡを含む１つ以上の細胞を含む遺伝子導入植物及び植物の部分を提供する。ジカンバ−分解酵素の発現により、ジカンバ−耐性植物を含むジカンバ−分解生物体が産出される。この発明はさらに、この発明の遺伝子導入ジカンバ−耐性植物を含む畑で雑草を抑制する方法、及び有効量の本発明の遺伝子導入微生物またはジカンバ−分解酵素を物質に適用する工程を含むジカンバを含む物質の除染方法を提供する。最後に、この発明はジカンバ耐性に基づく形質転換された植物及び植物細胞の選択方法、及びジカンバの分解により生成する３，６−ジクロロサリチル酸の蛍光に基づく形質転換された宿主細胞、完全な生物体及び生物体の部分の選択またはスクリーニング方法を提供する。
Patent JP-2001520821-A (JP)
IPC: H04B3/04
Filed: 1998-04-14
Abstract: A dual-processing interference cancelling system and method for processing a broadband input in a computationally efficient manner. Dual processing divides the input into higher and lower frequency bands and applies adaptive filter processing to the lower frequency band while applying non-adaptive filter processing to the higher frequency band. Various embodiments are shown including those based on sub-bands, broadband processing with band-limited adaptation, and broadband processing with an external main-channel generator.
Patent JP-2000515959-A (JP)
Title: 加熱調理プロセスを個別に行う方法とそれに関連する加熱調理機器
IPC: A23L5/10
Filed: 1998-04-30
Abstract: (57)【要約】
本発明は、加熱調理室（１）と、加熱調理物質の特性に関する加熱調理状態変数の値を検出するための測定装置（３，４）とを備えた加熱機器内で、加熱調理するための方法に関する。この加熱調理状態変数の値は加熱調理プロセスに基づいて変化する。加熱調理プロセスは測定された少なくとも１つの加熱調理状態変数の値に従って行われる。加熱調理プロセスは加熱調理プロセス中の加熱調理状態変数の時間による微分商の１つまたは複数の値に従って行われる。本発明は更に、本発明による方法を実施するための加熱調理機器に関する。
Patent JP-2001522530-A (JP)
Title: 集積回路のコンデンサ
IPC: H01L21/02
Filed: 1998-04-03
Abstract: (57)【要約】
本発明は、集積回路の製造において、金属導電電極を備えたコンデンサを製造する方法と、コンデンサそれ自身と、好ましくは高周波数への応用を目指した集積回路とに関する。本発明により、最も下側の基板と最も上側の絶縁体層１３とを有する層構造体１１の上に第１金属層１５を沈着することにより、下側電極１７、６３、６７が作成される。第１金属層１５の上に絶縁体層１９が沈着される。その後、前記絶縁体層１９を貫通する貫通孔ホール２１をエッチングすることによりおよび貫通孔ホール２１を充填することにより、下側電極１７、６３、６７に対する電気的接続体２５が作成される。その後、所定の領域３３の中の第１金属層１５が被服されなくされる。その後、誘電体層３５が前記所定の領域３３に重なる３９ように、誘電体層３５が沈着されおよびパターンに作成されおよびエッチングが行われる。最後に、上側電極４７、６３、６７および接続層４３がそれにより達成される構造体４０の上に沈着される第２金属層４７により作成される。ここで、上側電極４７、６３、６７が前記所定の領域３３に重なる３９ようにおよび接続層４３が充填された貫通孔ホール２１に重なるように、第２金属層４７がパターンに作成されそしてエッチングが行われる。
Patent JP-2001515511-A (JP)
IPC: A01N59/02
Filed: 1998-04-22
Abstract: A powder for sustained release of a gas including a hydrophilic core, a hydrophobic layer on an outer surface of the hydrophilic core, and particles in contact with the hydrophobic layer. The hydrophobic layer contains an acid releasing agent. The particles contain an anhydrous material capable of binding with water. The core, the particles, and the hydrophobic layer are substantially free of water, and the core is capable of generating and releasing a gas after hydrolysis of the acid releasing agent.
Patent NZ-206017-A (NZ)
Title: Cephalosporin derivatives and pharmaceutical compositions
Inventor: KINAST G
IPC: C07D501/46
Filed: 1983-10-20
Abstract: Antibacterially active cephalosporins of the formula   <IMAGE>   in which R1 denotes C1-C6-alkyl, phenyl or halogen-substituted phenyl, and R2 and R3, which can be identical or different, denote H, C1-C4-alkyl, chlorine, bromine, carbamoyl or N-C1-C4-alkylcarbamoyl.
Patent NZ-206935-A (NZ)
Title: Transferring containers with wet labels from mandrel conveyor to chain conveyor using disc with vacuum heads
Inventor: STIRBIS J S
IPC: B65G29/02
Filed: 1984-01-25
Abstract: Apparatus for continuously conveying decorated container members having wet ink images on the outer periphery thereof between a first continuously moving rotatable mandrel wheel type container carrying apparatus of a high speed container decorator or coater machine and a high speed second continuously linearly moving pin chain container carrying apparatus comprising: a continuously rotatable disk type conveyor means rotatably movable in a predetermined endless path between the first and second continuously moving container carrying apparatus including a first path portion located in juxtaposition to the first continuously moving container carrying apparatus for receiving decorated container members therefrom and a second path portion located in juxtaposition to the second continuously moving container carrying apparatus delivering decorated container members thereto; a plurality of individual circumferentially spaced vacuum cup means fixedly peripherally mounted in equally spaced relationship on and extending laterally outwardly of and being continuously movable with said disk type conveyor means in fixed relationship therewith for holding a single container member on each of said vacuum cup means, only by application of vacuum thereto during movement between the first and second continuously moving container carrying apparatus and for releasing container members therefrom only by removal of vacuum therefrom; and vacuum chamber means extending along the path of movement of and in substantially seaied relationship with said disk type conveyor means between the first and second continuously movable container carrying apparatus and being connected to each of said vacuum cup means adjacent to the first continuously moving container carrying apparatus for receiving and holding container members delivered therefrom and being disconnected from each of said vacuum cup means adjacent to the second continuously moving container carrying apparatus for releasing the container members for supportive engagement therewith and being continuously connected to each of said vacuum cup means during movement between the first continuously moving container carrying apparatus and the second continuously moving container carrying apparatus for holding the container members thereon solely by applied vacuum during non-supportive association with the second continuously moving container carrying apparatus.
Patent NZ-219249-A (NZ)
Title: Quinoline derivatives, and pharmaceutical compositions containing such
Inventor: YOUNG ROBERT NORMAN
IPC: C07D215/48
Filed: 1987-02-12
Abstract: 2-Substd. quinoline cpds. of formula (II) and pharmaceutically acceptable salts are new where R1 = H, halogen, 1-8C alkyl, 2-8C alkenyl, 2-8C alkynyl, CF3, OR2, SR2, S(O)R2, SO2R2, NR2R3, CHO, COOR2, COR2, -C(OH)(R2)2, CN, NO2, opt. substd. phenyl, opt. substd. benzyl or opt. substd.phenyl, opt. substd. benzyl or opt. substd. phenethyl; R2 = H, 1-8C alkyl, 2-8C alkenyl, 2-8C alkynyl, CF3, opt. substd. phenyl, opt. substd. benzyl or opt. substd. phenethyl; R3 = H, halogen, NO2, CN, OR2, SR2, N(R2)2 or 1-8C alkyl; CR2R3 may be the radical of a naturally occurring amino acid, R4 = H, halogen, NO2, CN, OR2, SR2, N(R2)2, 1-8C alkyl or COR2, R5 = (CH2)s-C(R6)2-(CH2)s-R7, R6 = H or 1-4C alkyl; R7 = W-R8 or mono- or bicyclic heterocyclic gp. contg. 3-12 ring C and 1 or 2 N, O or S heteroatoms, each ring being 5- or 6-membered; R8 = max. 21C hydrocarbyl or acyl residue of an acyclic or monocyclic carboxylic acid contg. max. heteroatom in the ring; R9=OR10, SR10, or N(R10)2; R10 = H, 1-6C alkyl, -COR11, phenyl or benzyl, or N(R10)2 may form a 5- or 6-membered ring contg. up to 2 N,O or S heteroatoms; R11 = H, 1-8C alkyl, 2-8C alkenyl, 2-8C alknyl, CF3, phenyl, benzyl or phenethyl; R12 = R2 or halogen; m,m'= 0-8; n,n'= 0 or 1; p,p'= 0-8; m+n+p = 1-10; m'+n'+p'= 1-10; s = 0-3; Q1,Q2 = COOR2, tetrazole, COOR5, CONHSO2R11, CM, CON(R10)2, CHO, CH2OH, COCH2OH or NHSO2R11; or if Q1 or Q2 = COOH and R3 = OH, SH or NHR2, then Q1 or Q2 and R3 and the C atoms through which they are attached may form a heterocyclic ring with loss of water; W= O,S or NH; X'= O, S, SO2, NR2 or C(R2)2; X2, X3 = O, S, SO or SO2, Y = -CR2=CR2-, ethynylene, -C(R2)2-X1-, -X1-C(R2)2-, -C(R2)2-X'-C(R2)2-, -CO-, -NR2-CO-, -CO-SR2-, O, S, NR2 or cyclopropanedinyl of formula (a); Z1,Z2 = -CONR2-.
Patent NZ-219796-A (NZ)
Title: Round hay bale press with stripping knife for chamber roller: preserving uniform pressure of knife along roller
Inventor: BERKERS A
IPC: A01F15/00
Filed: 1987-03-27
Abstract: A round bale press for agricultural stalk material which has a housing defining a pressing chamber with variable volume. The pressing chamber is defined by opposed side walls of the housing and at least one continuous belt within the chamber. The belt is guided by a plurality of cylindrical rollers. At least one stripping device is attached to the housing adjacent one of the rollers which is adjacent to the feeding area. The stripping device consists of a rail with supporting plates on both end sections. On said rail a steel knife blade is mounted for contacting the surface of the roller with uniform contact pressure over the longitudinal extension of the roller surface. At least one clamping device is integrated into the stripping device which is actuatable from outside the housing side walls for bending a central section of the rail relative to the end sections of said rail. A uniform contact pressure between the knife blade and the surface of the roller is achieved. Furthermore, said contact pressure of the knife is readjustable also during operation and in the assembled condition of the round bale press.
Patent NZ-225115-A (NZ)
Title: Fm audio carrier in video transmission
Inventor: MARZ D
IPC: H04N7/04
Filed: 1988-06-21
Abstract: Circuitry for producing an extremely linear frequency modulated audio carrier for use in the headend of a video signal distribution system, such as a cable television system. A reference oscillator (10) operating at a relatively high frequency, such as the video carrier frequency, generates a signal which is divided down (18) to a relatively low frequency. A voltage controlled oscillator (24) operating at the relatively low frequency is used to frequency modulate the audio signal. After modulation, the audio carrier is upconverted (28, 42) utilizing a signal frequency which is also derived from the original reference frequency, thus providing a stable and linear frequency modulated audio carrier particularly suitable for transmission of stereo program audio.
Patent NZ-231055-A (NZ)
Title: Process for the preparation of penem derivatives
Inventor: O'NEILL BRIAN THOMAS
IPC: C07D499/86
Filed: 1989-10-18
Abstract: An efficient, multistep process for the synthesis of certain 6-(1-hydroxyethyl) 2-substituted penem antibiotics from 2-[4R-(triphenylmethylthio)-3S-(1R-(dimethyl-t-butyl silyloxy)ethyl)-2-azetidon-1-yl]acetic acid esters.
Patent NZ-241580-A (NZ)
Title: Fibre-optic optical amplifier: mode field diameters of coupler and doped fibres matched
Inventor: PFEIFFER THOMAS
IPC: H04B10/29
Filed: 1992-02-11
Abstract: In order to increase the pumping efficiency, in an optical fibre amplifier the pump coupler (2) is produced from a fibre whose mode spot size the pump light is matched to the mode spot size of the active fibre piece (7). 
<??>In an alternative solution, the branch of the pump coupler (2) which is coupled to the pump light source (1), on the one hand, and is connected to the active fibre piece (7), on the other hand, consists of a fibre matched to the mode spot size of the active fibre piece (7) and the branch of the pump coupler (2) serving to connect the incoming transmission line (8) consists of a fibre corresponding to the optical fibre of the transmission line (8). 
<IMAGE>
Patent NZ-242511-A (NZ)
Title: Circuit breaker handle prevented from moving to off position when contacts welded closed
Inventor: CHOU YU WEI
IPC: H01H73/02
Filed: 1992-04-27
Abstract: A circuit breaker including a handle which is blocked from movement to the off position, when the contacts are welded closed, so as to prevent rotation of the common cross-bar on which contact arms carrying the movable contacts are mounted, by an interlock which includes radial extensions on the arms of a pivoted handle yoke which radially engage projections on the cross-bar. <IMAGE>
Patent NZ-244744-A (NZ)
Title: Skin-care aqueous gels with ph below 4 comprising a non-ionic polyacrylamide
Inventor: DECKNER GEORGE ENDEL
IPC: A61K8/00
Filed: 1992-10-15
Abstract: A skin care composition in the form of a low pH aqueous gel. The compositions provide improved skinfeel and residue characteristics together with excellent moisturizing, emolliency, rub-in and absorption characteristics.
Patent NZ-247642-A (NZ)
Title: Thioalkylacyl substituted heterocyclic compounds; pharmaceutical compositions and preparatory methods
Inventor: KARANEWSKY DONALD S
IPC: A61K38/55
Filed: 1993-05-18
Abstract: Compounds of the formula <CHEM> are disclosed as possessing inhibotory activity against angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) and thus being useful as cardiovascular agents. Processes for preparing these compounds are also disclosed.
Patent NZ-257218-A (NZ)
Title: Androstane steroid-containing medicament for nasal administration
Inventor: BERLINER DAVID L
IPC: A61P25/00
Filed: 1993-09-28
Abstract: The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human semiochemical, e.g. an Androstane steroid, or a pharmaceutical composition containing a semiochemical, such that the ligand semiochemical binds to a specific neuroepithelial receptor. The steroid or steroids is/are preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers. Other embodiments of the invention include pharmaceutical compositions containing the steroids.
Patent NZ-279625-A (NZ)
Title: Delta-12(13)-iso-taxol and baccatin iii analogues
Inventor: KELLY ROBERT C
IPC: C07D407/12
Filed: 1995-01-26
Abstract: PCT No. PCT/US95/00551 Sec. 371 Date Jul. 23, 1996 Sec. 102(e) Date Jul. 23, 1996 PCT Filed Jan. 26, 1995 PCT Pub. No. WO95/20582 PCT Pub. Date Aug. 3, 1995This invention provides 7-deoxy- DELTA 12,13-iso-taxol of formula (I) which are useful for the treatment of the same cancers for which taxol has been shown active.    <IMAGE>  (I)
Patent NZ-283863-A (NZ)
Title: Human mgdf polypeptide (mpl ligand) and pharmaceutical compositions
Inventor: BARTLEY TIMOTHY D
IPC: C07K14/475
Filed: 1996-03-12
Abstract: Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands), that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately to result in the production of platelets. MGDF derivatives comprising MGDF molecules attached to water soluble polymers, such as polyethylene glycol, are also disclosed, along with methods for their preparation. Also disclosed are processes for obtaining the MGDFs in homogeneous form from natural sources and producing them by recombinant genetic engineering techniques from mammals, including humans.
Patent NZ-287024-A (NZ)
Title: Progesterone antagonists useful for preparing medicaments for treating dysfunctional uterine bleeding
Inventor: CHWALSZ KRISTOF
IPC: A61K31/567
Filed: 1996-10-01
Abstract: Competitive progesterone antagonists are used for the production of a pharmaceutical for the treatment of dysfunctional uterine bleeding.
Patent NZ-314267-A (NZ)
Title: Vaccine container containing two or more freeze-dried bodies, at least one body being a lyosphere
Inventor: WILDERBEEK ANTONIUS THEODORUS
IPC: A61J3/00
Filed: 1997-02-19
Abstract: The present invention relates to a vaccine container that contains one or more freeze-dried vaccine components. The vaccine component or components are present in two or more freeze-dried bodies, at least one of which is a lyosphere. Furthermore, the invention relates to methods for the preparation of such a vaccine container. Also, the invention relates to a vaccine pack, comprising the vaccine container.
Patent NZ-331111-A (NZ)
Title: Pressure relief valve, typically for dairy tanker, able to accommodate some pressure and/or vacuum fluctuation without discharge of product, by movement of valve element while maintaining sealing effect
Inventor: MORATTI TERRENCE JOHN
IPC: F16K17/196
Filed: 1998-07-28
Abstract: The valve is typically attached to a milk tanker.  Valve element 17 moves upwards but is maintained in sealing contact with valve sleeve 10 a predetermined distance before uncovering ports 16 to allow venting.  This is stated to allow for some liquid surge before venting occurs.  Optionally vacuum relief is also provided for by valve elements 25 uncovering ports 22 during vacuum conditions.
Patent NZ-331142-A (NZ)
Title: Bridged cyclic amino acids as pharmaceutical agents
Inventor: HORWELL DAVID CHRISTOPHER
IPC: A61P25/28
Filed: 1997-02-18
Abstract: A compound of formula I, a pharmaceutically acceptable salt thereof or a prodrug thereof wherein A is a bridged ring selected from formulae 1-5 wherein, R1 and R2 are each independently selected from hydrogen and methyl, R3 and R4 are each independently selected from hydrogen or methyl, n is an integer of from 1 to 4 and, m is an integer of from 0 to 2.  These compounds are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, and neuropathological disorders.
Patent NZ-331815-A (NZ)
Title: A method for preparing cell lines that have artificial chromosomes, uses thereof and methods for preparing artificial chromosomes in particular they are satellite artificial chromosomes that are composed of heterochromatin and the inserted heterologous DNA
Inventor: HADLACZKY GYULA
IPC: A01K67/027
Filed: 1997-04-10
Abstract: The specification describes the preparation of artificial chromosomes, in particular,  isolated substantially pure satellite artificial chromosomes. Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. In particular, satellite artificial chromosomes that, except for inserted heterologous DNA, are substantially composed of heterochromatin, are provided. Methods for use of the artificial chromosomes, including for gene therapy, production of gene products and production of transgenic plants and animals are also provided.
Patent NZ-332237-A (NZ)
Title: Vitamin D analogues
Inventor: BRETTING CLAUS AAGE SVENSGAARD
IPC: A61P25/00
Filed: 1997-05-15
Abstract: The application relates to compounds of formula (I), in which formula X is hydrogen or hydroxy; R1 and R2, which may be the same or different, stand for hydrogen or a C1-C3 alkyl radical; or R1 and R2, taken together with the carbon atom bearing the group X, can form a C3-C6 carbocyclic ring; R3 stands for a C1-C3 alkyl radical, an aryl or an aralkyl radical, or for YR4, in which Y stands for the radicals -CO-S-, -CS-O- or -CS-S-, and R4 stands for a C1-C3 alkyl radical or an aryl or an aralkyl radical; Q is (CH2)n, n being 1-4. R1, R2 and Q independently may optionally be substituted with one or more fluorine atoms. The compounds show strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells as well as immunomodulating and anti-inflammatory effects.
Patent NZ-333063-A (NZ)
Title: Dibenzofuran sulfonamide derivatives as matrix metalloproteinase inhibitors
Inventor: O'BRIEN PATRICK MICHAEL
IPC: A61P19/02
Filed: 1997-08-22
Abstract: Use of a compound of formula I wherein: M is a natural (L) alpha amino acid; X is O, S, S(O)n, CH2, CO, or NRQ; RQ is hydrogen, alkyl, or alkyl-phenyl; R is a side chain of a natural alpha amino acid; R1 is alkoxy, hydroxy, or -NHOR5; R2 and R4 are independently hydrogen, alkyl, phenyl -NO2, halogen, -OR5, -CN, -CO2R5, -SO3R5,-CHO, -COR5, -CONR5R6, -(CH2)nNR5R6, -CF3, or -NHCOR5; R5 and R6 are independently hydrogen or alkyl and n is 0 to 2, in the manufacture of a medicament for inhibiting a matrix metalloproteinase.
Patent NZ-337800-A (NZ)
Title: Recombinant protein C and protein S variants
Inventor: DAHLBACK BJORN
IPC: C12N9/64
Filed: 1998-03-18
Abstract: A variant blood coagulation component, which is substantially homologous in amino acid sequence to wild-type blood coagulation component capable of expressing anticoagulant activity in the protein C-anticoagulant system of blood and selected from protein C (PC), activated protein C (APC) and protein S (PS). The variant component is capable of expressing an anticoagulant activity, which is enhanced in comparison with the anticoagulant activity expressed by the corresponding wild-type blood coagulation component, and the variant component differing from the respective wild-type component, in that it contains in comparison with the wild-type component at least one amino acid residue modification in its amino acid residue sequence.
Patent NZ-338105-A (NZ)
Title: Gastroretentive controlled release microspheres for improved drug delivery comprising bisphosphonate as an active ingredient
Inventor: ILLUM LISBETH
IPC: A61P31/04
Filed: 1998-05-22
Abstract: A drug delivery composition for the controlled release of an active ingredient, eg one useful in the treatment if Helicobactor pylori or Campylobacter pylori in the stomach environment over a prolonged period of time.  The composition comprises a microsphere that comprises an active ingredient in the inner core of the microsphere and i) a rate controlling layer of a water insoluble polymer and ii) an outer layer of a bioadhesive agent, such as chitosan or diethylaminoethyldextran, in the form of a cationic polymer.
Patent NZ-501784-A (NZ)
Title: Transgenic nonhuman mammals capable of secreting a lysosomal protein containing mannose 6-phosphate into milk
Inventor: REUSER ARNOLD J J
IPC: A23C9/15
Filed: 1996-07-31
Abstract: Transgenic nonhuman mammals (mice, rabbits, goat, sheep, pigs and cows) producing phosphorylated lysosomal proteins in their milk, and methods of generating the same are discussed.  Phosphorylation occurs at the 6' position of a mannose side chain residue.  Methods of purifying lysosomal proteins from milk and incorporating the proteins into pharmaceutical compositions for use in enzyme replacement therapy are also discussed.  The purified protein can then be mixed with a pharmaceutical carrier for intravenous, intradermal, intramuscular or oral administration. The transgene in the transgenic mammal comprises a mammary gland specific promoter, a mammary-gland specific enhancer, a secretory DNA segment encoding a signal peptide functional in mammary secretory cells, and a recombinant DNA segment encoding a lysosomal protein, usually an enzyme. The recombinant DNA segment is operably linked to the secretory DNA segment to form a secretory recombinant DNA segment. The secretory-recombinant DNA segment is in turn operably linked to the promoter and to the enhancer. The transgene, in an adult, is capable of expressing the secretory-recombinant DNA segment in the mammary secretory cells to produce a form of the lysosomal protein that is processed and secreted by the mammary secretory cells into milk as a mannose 6-phosphate containing lysosomal protein. The concentration of the mannose 6-phosphate containing lysosomal protein in the milk is usually at least 100 pg/ml.
Patent NZ-510902-A (NZ)
Title: Isolated peptides which bind to HLA-B35 molecules
Inventor: BOON-FALLEUR THIERRY
IPC: C12N5/10
Filed: 1999-10-04
Abstract: Peptides that bind to HLA-B35 molecules, leading to recognition and lysis of the resulting complexes by cytolytic T cells are disclosed.  Nucleic acid molecules that encode these peptides, and uses of each of these, molecules that are derived from tyrosinase, portions of the tyrosinase molecule and portions of nucleic acid molecules that encode tyrosinase are also disclosed.