baber/WOPTO huggingface dataset:
Patent NZ-718960-A (NZ)
Title: Formulation for gonadotropins
Inventor: MENDIRATTA SANJEEV KUMAR
IPC: C07K14/59
Filed: 2014-10-31
Abstract: The present invention relates to a stable composition for gonadotropins. It provides a composition useful for stabilization of gonadotropins while preventing aggregation, dissociation, fragmentation and formation of oxidized species variants in solution for injection. Thus, it prevents instability of protein or polypeptide molecules caused due to aggregation or fragmentation or oxidation during or after formulation. Also, it provides a pharmaceutical composition of gonadotropins, which can be therapeutically used for the treatment of various indications either in single-dose form or in multi-dose form.
Patent NZ-719452-A (NZ)
Title: High-speed centrifugal mixing devices and methods of use
Inventor: HOFFMAN STEVEN
IPC: B01F29/90
Filed: 2014-10-21
Abstract: Preferred embodiments of the present invention seek to provide a lighter centrifugal device that is capable of achieving greater speeds. A centrifugal mixing device can include a shaft assembly that is operably coupled to a motor such that the motor rotates the shaft assembly about a first axis. The devices can further include a turret that is rotatably coupled to the shaft assembly such that the turret rotates about the first axis relative to the shaft assembly. The turret can include a first support, a first canister rotatably coupled to the first support such that the first canister rotates about a second axis, and a second canister rotatably coupled to the first support such that the second canister rotates about a third axis. The turret can further include a second support spaced from the first support along the first axis, the first and second canisters being rotatably coupled to both the first support and the second support. The turret is configured to rotate about the first axis in a first rotational direction and each of the first and second canisters is configured to rotate about the second and third axes, respectively, in a second rotational direction that is opposite the first rotational direction.
Patent NZ-723978-A (NZ)
Title: Genes involved in noscapine production
Inventor: WINZER THILO
IPC: C12N15/82
Filed: 2013-03-12
Abstract: Discloses isolated nucleic acid molecules encoding two or more genes involved in noscapine production, including a carboxylesterase gene with the sequence 80% identical to SEQ ID NO: 8 or encoding a polypeptide sequence 75% identical to that of SEQ ID NO: 18. Discloses use of nucleic acids and polypeptides in the biosynthesis of Papaver somniferum opiate alkaloids. Further dependent claims to a cluster of 10 genes involved in noscapine production, vectors and their expression in plant, microbial and insect cells.
Patent NZ-725150-A (NZ)
Title: Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators
Inventor: AISSAOUI HAMED
IPC: A61K31/437
Filed: 2015-03-16
Abstract: The present invention relates to azaindole acetic acid derivatives of formula (I), wherein R1 and R2 are as described in the description, and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.
Patent NZ-728127-A (NZ)
Title: Antiproliferative compounds and methods of use thereof
Inventor: MULLER GEORGE W
IPC: C07D401/14
Filed: 2015-07-10
Abstract: Compounds of formula (I) for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such as leukemia, comprising administering the compounds. In certain embodiments, the method of treatment comprise administering a compound provided herein in combination with a second agent. Pharmaceutical compositions and single unit dosage forms comprising the compounds are also disclosed. In Formula (I) R1 is optionally substituted cycloalkyi, aryl, heteroaryl or heterocyclyl; and R2 and R3 are each halo.
Patent NZ-728449-A (NZ)
Title: Foam formulations and emulsifiable concentrates
Inventor: MARTIN TIMOTHY
IPC: A01N25/04
Filed: 2015-06-24
Abstract: The present invention is directed to an agricultural foam comprising a foaming formulation and a gas, the foaming formulation comprising: (i) an emulsifiable foaming concentrate comprising: (a) bifenthrin, (b) 30 to 65 wt%, based on the emulsifiable foaming concentrate, of a linear liquid amide selected from the group consisting of N,N-dimethyloctanamide, N,Ndimethyldecanamide, and mixtures thereof (e.g. Hallcomid M-8-10), and (c) between 5 and 25 wt%, based on the emulsifiable foaming concentrate, of a foaming agent selected from sodium decyl sulfate, sodium lauryl sulfate and sodium dodecylbenzene sulfonate; and (ii) water; wherein said gas is air, and wherein the ratio of the linear liquid amide to the agriculturally active ingredient is between 2:1 to 4:1.
Patent NZ-733854-A (NZ)
Title: Pd-1 / pd-l1 inhibitors for the treatment of cancer
Inventor: CUILLEROT JEAN-MARIE
IPC: C07K16/30
Filed: 2016-02-23
Abstract: The invention relates to methods of treating non-small cell lung cancer in a subject, comprising administering to the subject a therapeutically effective amount of an anti-PD-L1 antibody, in particular avelumab, wherein the subject has not previously received therapy for metastatic or recurrent disease.
Patent NZ-744468-A (NZ)
Title: 2-oxindole compounds
Inventor: SINGH RAJINDER
IPC: C07D209/34
Filed: 2017-01-18
Abstract: Oxindole compounds of Formula (I) useful for the treatment of CCR(9) mediated conditions or diseases are provided.
Patent NZ-749317-A (NZ)
Title: Methods for treating seeds with an aqueous compostion and seeds treated therewith
Inventor: EKIN ABDULLAH
IPC: A01N25/00
Filed: 2017-07-03
Abstract: Disclosed are methods for treating seeds with a seed treatment composition that includes: (A) an aqueous polyurethane dispersion; and (B) an insecticide, a fungicide, a nematicide, and/or other pesticides. Also disclosed are seeds treated with such a treatment compositions and methods for treating a seed using such treatment composition.
Patent NZ-759691-A (NZ)
Title: Morphic forms of git38 and methods of manufacture thereof
Inventor: ANDRES PATRICIA
IPC: A61K31/519
Filed: 2018-06-29
Abstract: This invention provides an unexpectedly stable, highly crystalline form of the di-HCl salt of 2’-((5-(4-isopropylpiperazin-l-yl)pyridin-2-yl)amino)-7’,8’-dihydro-6’H-spiro[cyclohexane-1,9’-pyrazino[1’2’:1’5]pyrrolo[2,3-d]pyrimidin]-6’-one for advantageous therapeutic pharmaceutical efficacy and dosage form stability.
Patent NZ-768064-A (NZ)
Title: Eutectic formulations of cyclobenzaprine hydrochloride
Inventor: LEDERMAN SETH
IPC: A61K31/135
Filed: 2015-09-18
Abstract: The present invention relates to eutectics and methods of manufacturing the same, the eutectic comprising 65%±2% by weight Cyclobenzaprine HCl and 35%±2% by weight δ-mannitol.
Patent NZ-773625-A (NZ)
Title: Reference picture management in video coding
Inventor: HENDRY FNU
IPC: H04N13/00
Filed: 2019-08-16
Abstract: A method of decoding a coded video bitstream implemented by a video decoder is provided. The method includes parsing a slice header of a current slice represented in the coded video bitstream. The slice header includes a reference picture list syntax structure. The method also includes deriving, based on the reference picture list syntax structure, a reference picture list of the current slice; and obtaining, based on the reference picture list, at least one reconstructed block of the current slice, where an order of entries in the reference picture list syntax structure is the same as an order of corresponding reference pictures in the reference picture list.
Patent PT-101675-A (PT)
Title: Tap with semi-automatic water temperature regulation system
IPC: G05D23/02
Filed: 1995-03-28
Abstract: Monobloc thermostatic mixer consisting of a water mixing chamber 35, where there is an antechamber 24 with mercury inside which once contacted by the hot water increases the volume of the mercury, which will exert pressure on the piston 25 making it open up to the passage of cold water 27 supplied by the channel 28 needed to reach the desired temperature, which will be regulated by the fine adjustment made through the shaft 19 which will lower or raise the plugs 40 and 37 at the same time, opening or closing the respective water flows. <IMAGE>
Patent PT-103685-A (PT)
Title: Compostos flavonóicos extraídos de hedychium gardnerianum e sua utilização como agentes anticoagulantes
Inventor: MEDEIROS JORGE MANUEL ROSA DE
IPC: A61K36/906
Filed: 2007-03-09
Abstract: A PRESENTE INVENÇÃO DIZ RESPEITO À UTILIZAÇÃO DAS COMPOSIÇÕES DE FLAVONÓIDES 3,5-DIHIDROXI-4',7-DIMETOXIFLAVONA (FIGURA I) E 5-HIDROXI-3,4',7-TRIMETOXIFLAVONA (FIGURA II) COMO AGENTES ANTITROMBINA, EXTRAÍDOS DE HEDYCHIUM GARDNERIANUM. ESTAS COMPOSIÇÕES REVELAM GRANDE UTILIDADE NA INDÚSTRIA FARMACÊUTICA.
Patent PT-105792-A (PT)
Title: Plataforma submersa
Inventor: PARDAL TIAGO DA COSTA DUARTE
IPC: B63B35/44
Filed: 2011-07-05
Abstract: O presente invento consiste numa plataforma submersa, constituída por um corpo imerso (1) estanque, flutuante, ancorado ao fundo (8) de um corpo de água por meio de um componente de ancoragem (3) de modo a que se mantenha abaixo da superfície (7), visando evitar-se a ondulação. Este corpo imerso (1) inclui um tubo (5), ligado ao dito corpo imerso (1) através de uma articulação estanque (6), ficando a outra extremidade fora de água. A referida articulação (6) é concebida de modo a manter desobstruida a passagem entre o interior do tubo (5) e o interior do corpo imerso (1), permitindo a passagem de um componente estrutural (9), como por exemplo um cabo. A ancoragem e feita de modo a que a plataforma possa rodar sobre si própria horizontalmente. Este invento pode ser utilizado, por exemplo, na produção de energia eléctrica, desde que munido dos sistemas necessários para o efeito.
Patent PT-107353-A (PT)
Title: Amplificador mecânico para aplicação em estruturas para medição de extensões
Inventor: SANTOS SÉRGIO PEREIRA DOS
IPC: G01B5/30
Filed: 2013-12-11
Abstract: O PRESENTE INVENTO DIZ RESPEITO A UM AMPLIFICADOR MECÂNICO (1) PARA APLICAÇÃO EM ESTRUTURAS (3) PARA MEDIÇÃO DE EXTENSÕES, CAPAZ DE AUMENTAR A SENSIBILIDADE DOS TRADICIONAIS EXTENSÓMETROS. ESTE DISPOSITIVO IRÁ AMPLIFICAR A EXTENSÃO MECÂNICA DA ESTRUTURA BASE, REPRODUZINDO ESSE VALOR DE EXTENSÃO AMPLIFICADO NUMA ZONA SEPARADA DA ESTRUTURA BASE, ONDE SERÁ COLOCADO UM ELEMENTO SENSITIVO (2). A SECÇÃO (4) DE ÁREA VARIÁVEL (8) E A SECÇÃO (5) PROVOCAM UMA CONCENTRAÇÃO DE DEFORMAÇÕES NO ELEMENTO SENSITIVO (2) PROVOCADA PELO ESTRANGULAMENTO DE SECÇÃO. PARALELAMENTE O MESMO ELEMENTO ESTÁ SUJEITO AO MOMENTO FLETOR CRIADO PELA GEOMETRIA DO AMPLIFICADOR MECÂNICO. ATRAVÉS DO EFEITO DUPLO DE CONCENTRAÇÃO DE TENSÕES CONSEGUE-SE QUE A AMPLIFICAÇÃO OBTIDA NO ELEMENTO SENSITIVO (2) SEJA PROPORCIONAL E AMPLIFICADA DA DEFORMAÇÃO SOFRIDA PELA BASE (10). AS ABAS (6), DE COMPRIMENTO (7) E (9), PERMITEM A CORRETA FIXAÇÃO DA ESTRUTURA AMPLIFICADORA AO LOCAL EM QUE SE PRETENDE OBTER A MEDIÇÃO DA BASE (10).
Patent PT-107534-A (PT)
Title: Uso de pediococcus parvulus para a degradação e destoxificação biológica da ocratoxina a, respetivo método e kit
Inventor: FAIA MARIA ARLETE MENDES
IPC: A23L5/20
Filed: 2014-03-21
Abstract: A PRESENTE INVENÇÃO CONSISTE NO USO DE NOVAS ESTIRPES DE PEDIOCOCCUS PARVULUS PARA A DEGRADAÇÃO E DESTOXIFICAÇÃO BIOLÓGICA DA OCRATOXINA A QUE SE ENCONTRA EM ALIMENTOS OU BEBIDAS PARA CONSUMO HUMANO OU ANIMAL. ESTAS NOVAS ESTIRPES SEQ. ID N° 1, SEQ ID N° 2 E SEQ ID N° 3, TÊM A CAPACIDADE DE HIDROLISAR A OCRATOXINA A EM OCRATOXINA A EM MENOS DE 20 HORAS. A PRESENTE INVENÇÃO DESCREVE TAMBÉM O RESPETIVO MÉTODO QUE CONSISTE, EM TERMOS GERAIS NA INCUBAÇÃO DAS ESTIRPES, FERMENTAÇÃO DAS MESMAS, PRODUÇÃO E RESPETIVA RECOLHA DE CÉLULAS VIÁVEIS, LIOFILIZAR AS MESMAS E POR FIM, ADICIONAR E MISTURAR AOS ALIMENTOS. NUMA REALIZAÇÃO, APRESENTA-SE AINDA UM KIT PARA UMA FÁCIL UTILIZAÇÃO DA INVENÇÃO.
Patent PT-108114-A (PT)
Title: Estrutura de parede para armazenamento de água
Inventor: MARCELO FÁBIO NUNES CAETANO
IPC: E03B3/03
Filed: 2014-12-22
Abstract: A PRESENTE INVENÇÃO ENQUADRA-SE NA ÁREA DOS SISTEMAS DE RECOLHA E ARMAZENAMENTO DE ÁGUA EM EDIFÍCIOS, MAIS ESPECIFICAMENTE DENTRO E ENTRE AS PAREDES (1) DE UMA HABITAÇÃO. É ASSIM OBJECTO DA PRESENTE INVENÇÃO UMA ESTRUTURA DE PAREDE PARA ARMAZENAMENTO DE ÁGUA QUE CONTÉM: - PELO MENOS UM DEPÓSITO (4) DE ÁGUA; - UMA ESTRUTURA PERFILADA ADEQUADA PARA SUPORTAR O, PELO MENOS UM, DEPÓSITO (4) DE ÁGUA; - TUBOS DE INTERLIGAÇÃO ENTRE DEPÓSITOS (13), LIGADOS A CADA DEPÓSITO (4) DE ÁGUA; - PELO MENOS DUAS PAREDES (1), QUE CONTÊM TODOS OS ANTERIORES COMPONENTES ENTRE SI.
Patent RO-89144-A (RO)
Inventor: LEE LEN F
IPC: C07D405/04
Filed: 1984-08-10
Abstract: An improved process for the preparation of a compound of the formula   <CHEM> wherein X is NH; R1 is selected from lower alkyl, phenyl, heterocyclic radicals having 3-6 atoms in the ring with 1-3 atoms selected from O, S, and N; R2 is a C1-4 alkyl radical and R3 represents a C1-4 fluoroalkyl radical, comprises reacting a 3-ketoester with an aldehyde in the presence of piperidine as a catalyst to form a corresponding pyran, i.e. a compound of the above formula in which X is oxygen, and then passing gaseous ammonia through the reaction mixture to react therewith to produce the desired compound.
Patent RU-94018471-A (RU)
Inventor: GENDEL MAN A B
IPC: B01D3/20
Filed: 1994-05-25
Abstract: FIELD: solid particle separation. SUBSTANCE: apparatus has set of inverted troughs 1 with openings 2 for distributing light phase (gas) and partition walls 3 with openings 4 cutting-off cross-section of cylindrical device with the exception of annular space 10 between apparatus and wall 9 of cylindrical device. Cross section of troughs 1 is narrowing in the direction of its top part. The number of openings 2 per area unit of trough wall is reducing toward top part. Openings 2 are disposed in zone defined by circles with diameters (0.25-0.55) D and (0.75-0.9) D, where D is inner diameter of cylindrical device. If apparatus may be completely introduced into device or by two halves, troughs may be disposed in radial arrangement and communicated with central tube open from bottom end and closed at top end. If only disassembled apparatus may be introduced into device, troughs are arranged in mutually perpendicular directions so as to be communicated one with the other. EFFECT: increased efficiency, simplified construction and enhanced reliability in operation. 1 dwg
Patent RU-94021759-A (RU)
Inventor: KRIVTSOV N I
IPC: A23L21/25
Filed: 1994-06-17
Abstract: FIELD: food-processing industry. SUBSTANCE: method involves (first variant) preparing honey solution and introducing flower pollen, citric acid and yeast into honey solution; providing fermentation of obtained wort, with amount of honey for preparing aqueous solution making 2/3 of honey weight used to prepare beverage, flower pollen-load being introduced into solution in dry ground state and wine yeast clean culture being used as yeast taken in an amount of 5-8% of the total volume of wort; conducting wort fermentation for 4-5 days; introducing remaining quantity of honey in the form of aqueous solution and continuing fermentation till 2-4% content of remaining sugar is obtained; removing fermented wort from sediment, filtering and pasteurizing at temperature not exceeding 80 C for 15-30 min; holding for 15-16 days at temperature not exceeding 10 C; repeatedly removing wort from sediment; introducing sugar in an amount providing sugar content of 6-10 g/cmand filtering. To obtain 1000 l of ready beverage, components are added in the following amounts: honey 300-450 kg, citric acid 1.8-2.2 kg, flower pollen-load 1.0-11.0 kg and water the balance. Second variant is effectuated in accordance with first variant, except that upon final stage of filtering, coupage with honey plant of 47-48 vol.%-concentration in an amount of 0.8-1.5 l per 1000 l of ready beverage is conducted. EFFECT: increased efficiency and improved quality of beverage. 6 cl
Patent RU-94025137-A (RU)
Inventor: EPIFANOV G V
IPC: A01C3/02
Filed: 1994-07-05
Abstract: FIELD: agriculture; livestock farming. SUBSTANCE: method for litterless cow or pig manure storage in a trench involves placing bales of straw in the trench before filling it with manure. The bales of straw are used as bricks to build partitions 3.0-3.5 m in height for dividing the trench into compartments. The holding capacity of a compartment is 200-300 t. The cross partitions are one row of straw bales, and the end faces are formed by two or three rows of straw bales. EFFECT: more solid manure; less costly manure disposal for subsequent application as organic fertilizer; higher organic fertilizer quality. 1 dwg
Patent RU-94027255-A (RU)
Inventor: PANKRUSHEVA T A
IPC: A61K9/06
Filed: 1994-07-18
Abstract: FIELD: pharmacy. SUBSTANCE: ointment has the following components, %: levomycetin 2; pyromecain 5; dill (or clove, or mint, or eucalyptus, or lavender) essential oil as basic active components, and additional agent - cetylpyridinium chloride (preserving agent) 0.01; glycerol 10; carboxymethylcellulose (or methylcellulose) sodium 4, and refined water - up to 100. Method of ointment preparing is developed. Method involves polymer gel preparing (cellulose base) and addition of medicinal substances, essential oils and preserving agent to it. Proposed ointment shows antimicrobial, analgetic and osmotic actions and used for treatment of suppurative-inflammatory and wound infections and mucous membranes. EFFECT: enhanced effectiveness of treatment.
Patent RU-94027947-A (RU)
Title: Automatic device for tableting (its variants
Inventor: DIBROV V F
IPC: B30B11/02
Filed: 1994-07-25
Abstract: FIELD: mechanical engineering. SUBSTANCE: automatic device for tableting has die, drive of lower punches coaxial to die seats and feeder mounted on bed-plate. Gate valve-batchmeter with drive for its reciprocal motions along upper surface of die is mounted between outlet window of feeder and die. Control members of drives (hydraulic distributors) and transducers of their position are made and are connected with control unit providing for possibility of finding lower punches in positions of dosing and ejection of finished products and of finding the gate valve in positions of charge of its dosing window and charge of die seats. To achieve the above-mentioned advantages upper punches with drive and transducer for fixating these punches in positions of molding and unloading the finished products are mounted on bed-plate above the die coaxial to its seats. In this case all members (body) of gate valve in position of charging its dosing window are disposed outside the zone of die seats. Gate valve-batchmeter itself and its drive are made so that transition of dosing window of gate valve-batchmeter can be provided behind the zone of arrangement of die seats. In another independent variant of automatic device for tableting the difference lies in the fact that all die seats are disposed in as less number or rows intersecting the line of gate valve displacements as possible (in the limit - in one row). To enhanced efficiency (per unit of mass and volume of automatic device) and to expand nomenclature of simultaneously molded articles the members are mounted on bed-plate from free side of feeder symmetrically to first position of molding. The members form second molding position, analogous to first one, with common feeder, control unit and gate valve-batchmeter mirror-extended towards it. EFFECT: enhanced efficiency of loose material tableting, enhanced quality of molded tablets (stability and uniformity of density), reduced waste, enhanced mass-overall characteristics. 5 cl, 6 dwg
Patent RU-94036590-A (RU)
Inventor: KADUSHIN P I
IPC: E21B19/00
Filed: 1994-09-30
Abstract: FIELD: mining industry, oil and gas equipment. SUBSTANCE: unit contains a frame of a transportation means, a mast with its lower end hinged to the frame, a hydraulic cylinder, a front support of the mast rigidly attached to the frame, and a linkage. The latter includes a first member with an end hinged to the frame. The linkage is also provided with a second member the lower end of which is fixed on the frame and the upper end is hinged with the other end of the first member. The hydraulic cylinder is hinged with the middle section of a rear support and with the upper end of the second member of the linkage, the first member of the linkage having a support interacting with the upper section of the rear support and the hydraulic cylinder being provided with a means to fix the mast in its retracted position. EFFECT: decreased dimensions of the unit in the transportation position, simplified design and increased operation safety under wind loads.
Patent RU-94039133-A (RU)
Inventor: MADATOV A V
IPC: F42B30/02
Filed: 1994-10-12
Abstract: FIELD: ammunition for sporting and hunting guns, in particular, cartridges fitted with a bullet. SUBSTANCE: due to provision of components linked by a connection strap, wedge-shaped central part and an antiricochet lug, the main part of kinetic energy of bullet translational motion is spent on creation of the shock wave front having an explosive effect on the target material. EFFECT: enhanced injurious effect of bullet, enhanced effectiveness of game- shooting, reduced percentage of wounded animals. 2 dwg
Patent RU-94040342-A (RU)
Inventor: NAKHSHUNOV V S
IPC: C07C15/02
Filed: 1994-11-02
Abstract: FIELD: processing of petroleum gas. SUBSTANCE: method involves contacting of paraffin hydrocarbons with catalyst on zeolite base, separation thus prepared products and combustion of gaseous products. Thus obtained mixture is then added to origin paraffin hydrocarbons, its quantity being not more 20 %. EFFECT: improves efficiency of the method.
Patent RU-94043799-A (RU)
Inventor: KSABA SANTAI
IPC: A61K31/40
Filed: 1994-12-09
Abstract: FIELD: organic chemistry. SUBSTANCE: product: compounds of the general formula (XVII)where R - lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, aryl, heteroaryl, aryl-lower alkyl or heteroaryl-lower alkyl where indicated groups can be substituted at definite conditions with one or some substituents - lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, aryl, heteroaryl, aryl-lower alkyl, heteroaryl-lower alkyl, hydroxy, lower alkoxy, phenoxy, halogen, halogen-lower alkyl, amine, mono- or disubstituted amine, amide and/or sulfonamide; and R' - hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, lower cycloalkenyl, lower cycloalkynyl, aryl-lower alkyl, aryl, heteroaryl, halogen-lower alkyl, hydroxy-lower alkyl or acyl; and pharmaceutically acceptable acid-additive salts of this compound showing very strong anesthetic action. Compounds of the formula (XVII)are new products under condition that R has other value than 6-chloro-3-pyridyl if R' - hydrogen. EFFECT: improved method of synthesis of new compounds indicated above.
Patent RU-95100127-A (RU)
Inventor: DUBININ A E
IPC: B61K9/06
Filed: 1995-01-05
Abstract: FIELD: railway transport; bearing overheating signalling devices. SUBSTANCE: temperature sensors 1 in form of reverse-biased "p-n" junctions of semiconductor elements are connected to earth fault detection unit 10 and in parallel with comparator unit 2. Connected to comparator unit 2 is reference voltage source 3. Reference voltage is formed by synchronizing unit 6. Synchronizing unit 6 is connected to sensors 1 and storage unit 4 coupled with comparator unit 2. Output of storage unit 4 is directly connected with logic unit 7 at one side and is connected with unit 7 through low-pass filter 8 at other side. Outputs of comparator unit 2, earth fault detection unit 10 and storage unit 4 are connected with light signalling unit 5. Output of logic unit 7 is connected with sound alarm unit 9. EFFECT: enlarged operating capabilities, reduced labour input in location of overheated bearing on car axle or defective sensor; enhanced reliability of operation, increased service life of device. 2 cl, 2 dwg