baber/WOPTO huggingface dataset:
Patent AT-E313068-T1 (AT)
Inventor: GOLDFORD MARC
IPC: C07K1/34
Filed: 1999-10-07
Granted: 2005-12-15
Abstract: Disclosed are mammalian thromboplastin reagents and methods for preparing such reagents. The thromboplastin reagents are suitable for use in prothrombin-time (PT) assays, and offer improved sensitivities with acceptable PT-normal times. Contaminating proteins-particularly plasma clotting factors-are separated from a thromboplastin solution by a membrane permeation protocol, in which the thromboplastin solution is exposed to a semipermeable membrane and clotting factors are allowed to pass from the thromboplastin solution through the membrane, while Tissue Factor is retained in the thromboplastin solution. In a preferred method, one or more contaminating clotting factors are separated by diafiltration from a NaCl/Na3Citrate thromboplastin extract of mammalian tissue, and the purified thromboplastin extract is combined with Ca++ ions to form a thromboplastin reagent.
Patent AT-E240054-T1 (AT)
Inventor: LE LEZ JEAN
IPC: A23N12/02
Filed: 1999-09-29
Granted: 2003-05-15
Abstract: The invention concerns a device comprising a rotary drum sieve (5) arranged at the outlet of the washing tank and mounted above a recycling tank (6) which is subdivided into two communicating sections, namely a first section (60) placed beneath the main drum (5), and a second section (61) whereto is connected the recycling circuit (80, 8, 81) which brings the water back into the washing tank. Said device comprises means for continuously eliminating by overflow insects and particles (i3) floating on the water of the first section (60) before transferring (N) said water into the second section (61). The invention is useful for washing various products, in particular vegetable products.
Patent DE-12790982-T1 (DE)
Title: Tischtennisschläger
Inventor: ZHESTEROVA LIDIYA MIKHAILOVNA
IPC: A63B59/40
Filed: 2012-07-27
Abstract: Tischtennisschläger, umfassend: eine Basis, einen daran angebrachten Griff, mindestens ein elastisches Polster, das mit der äußeren Basisfläche verbunden ist, und von dem elastischen Polster nach außen gerichtete, gleichmäßig verteilte und mit diesem verbundene Vorsprünge, dadurch gekennzeichnet, dass die Vorsprünge im Querschnitt T-förmig, in Form eines Beins und mit dem Bein in Verbindung stehenden Kopfs ausgebildet sind, wobei die Beine mit dem elastischen Polster verbunden sind und Köpfe benachbarter T-förmiger Vorsprünge miteinander kontaktieren.
Patent DE-41272-T1 (DE)
IPC: F24D11/00
Filed: 1981-06-03
Abstract: Heating installation for generating heat in a heat diffusion system (1) and for producing sanitary hot water stored in a tank (3), comprising at least one heat source (4) and at least one means for storing heat (5), comprising in addition a loop-shaped or ring pipe (8, 9), with this pipe comprising a first portion (8a) across the ends of which a pipe (10) associated thermally with the heat source (4) can be connected in parallel, a second portion (9a) across the ends of which a pipe (11) associated thermally with the heat storage means (5) can be connected in parallel and a third portion (8b) forming, with a sanitary water circulation pipe (12) external to the tank (3), a heat exchanger, with the heat diffusion system (1) being connected in parallel across this third portion (8b) forming the heat exchanger and with a heat pump (15) being installed between the said ring and the sanitary water of the tank ( 3).
Patent DE-114364-T1 (DE)
IPC: C02F1/46
Filed: 1983-12-21
Abstract: An electrolytic water sterilization system comprises a rate detecting cell, an oxidation cell and a silvering cell through which the water flows. The rate detecting cell is fitted with two electrodes and is partly filled with non-conducting particles whose density is greater than water. The upwards flow of water expands the bed of particles providing greater free area between the electrodes. The electrical resistance between the electrodes is reduced accordingly. The current to the electrodes of the oxidation cell and the silvering cell is controlled by the detected flow rate. Preferably, the rate detecting cell, the oxidation cell and the silvering cell with their corresponding electrodes are combined in one single cell.
Patent DE-126683-T1 (DE)
IPC: A01D65/00
Filed: 1984-05-11
Abstract: 1. Device for lifting vegetation for harvesting purposes, comprising a shoe (1) intended to slide on the ground and supported by an inclined lifting arm, this arm serving for raising the parts of plants moved away from the ground by the shoe (1), in order to bring them into a suitable position for harvesting, the lifting arm being connected to a support (6) fixed relative to harvesting means, such as a reaper, the lifting arm and the shoe (1) being capable of executing limited movements relative to the said fixed support (6) as a function of the unevenness of the ground by the agency of suitable means, the lifting arm being inclined relative to the ground at a fixed angle determined as a function of the type of vegetation, the said suitable means which ensure the limited movements comprising a cylindrical tube (10) and a piston (3) movable inside the cylindrical tube (10), characterized in that the said cylindrical tube (10) is fixed and integral with the said fixed support (6), whilst the piston (3) is integral with the shoe (1), and in that the lifting device has a section (4) surrounding the said tube (10) on the outside and fixed relative to the piston (3) and to the shoe (1), the said section (4) having a closed ring (5) surrounding the tube (10), this ring (5) coming up against the fixed support (6) in order to limit the downward movement of the shoe (1).
Patent DE-153870-T1 (DE)
IPC: A23L29/10
Filed: 1985-02-28
Abstract: @ A substantially free-flowing powder comprising a surface-active agent such as a food emulsifier applied on a particulate carrier such as a starch is prepared by mixing the surface-active substance with the carrier and subjecting the resulting mixture to extrusion.
Patent DE-748680-T1 (DE)
Inventor: EVANS ROWLAND FRANK
IPC: B29C45/78
Filed: 1991-11-14
Abstract: A temperature regulating system for a cyclic processor (10), for example an injection moulding machine, the machine having a mould with an internal passageway (17) for receiving temperature regulating fluid such as a coolant. The invention teaches intermittent flow of the temperature regulating fluid, the flow being permitted during certain parts only of the processing cycle, so that for example coolant cannot flow whilst hot melt material is being injected. The systems includes temperature control means (14) and cycle response means, characterised in that the cycle response means initiates operation of the temperature control means at a predetermined stage in a cycle. <IMAGE>
Patent DE-1094988-T1 (DE)
Inventor: BAIG SYLVIE
IPC: C02F1/72
Filed: 1999-06-04
Abstract: Destruction of organic pollutants in water by ozonization in the presence of a cobalt containing catalyst. Process for catalytic ozonization with molecular ozone or an ozone-containing gas in the purification of polluted water, the ozone being activated with a catalyst comprising at least atoms of Co to promote advanced oxidation of the organic contaminants in the water such that the Total Organic Carbon (TOC) content of the water is converted into CO2.
Patent ES-2093588-T1 (ES)
Title: Cerradura para cinturones de seguridad.
Inventor: BILLER JOACHIM
IPC: A44B11/25
Filed: 1995-07-25
Abstract: EL CIERRE PARA CINTURONES DE SEGURIDAD SE BASA EN UNA CONSTRUCCION DE BLOQUEO OSCILANTE DE CONSERVACION Y ESTA EQUIPADO CON MEDIDAS SENCILLAS EN EL TENSIONADO DEL CINTURON. EL PASADOR (16) DE OSCILACION ESTA ASEGURADO EN SU POSICION CERRADA POR MEDIO DE UNA PLACA (20) DE BLOQUEO. LA PLACA (20) DE BLOQUEO SE ASEGURA EN SU GIRO POR MEDIO DE DOS BOLAS (36) DE BLOQUEO SOPORTADAS ENTRE UN SURCO (28) EN LA PLACA DE BLOQUEO Y UNA PLACA (30) MOVIL EN LA DIRECCION PARALELA CON RESPECTO A LA PLACA DE BLOQUEO. PARA ABRIR EL CIERRE, ESTA PLACA (30) MOVIL DE BLOQUEO DEBE SER ACTUADA PRIMERO POR UN SISTEMA COMPENSADO DE MASA. EL CIERRE SE ASEGURA CONTRA ACELERACIONES EXTREMADAMENTE ALTAS EN TODAS DIRECCIONES.
Patent CY-1108216-T1 (CY)
Inventor: COLVIN ARTHUR E
IPC: A61B5/00
Filed: 2008-07-28
Abstract: An optical-based sensor (10) for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body (12) with a source of radiation embedded therein (18). A matrix layer is disposed on the surface of the sensor body which layer is permeable to an analyte and comprises fluroescent indicator molecules responsive to the concentration of the analyte. Radiation emitted by the source interacts with indicator membrane (3) indicator molecules (16) proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e,g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte.
Patent CY-1108691-T1 (CY)
Inventor: BASRAN AMRIK
IPC: C07K16/40
Filed: 2009-01-14
Abstract: Disclosed is a PEG-linked polypeptide comprising an antibody single variable domain, wherein the variable domain comprises a framework region and has an antigen binding site, and said variable domain binds antigen as a single antibody variable domain in the polypeptide, and further wherein said PEG is present as one or more molecules linked to the polypeptide at a cysteine or lysine residue in the framework regions of said antibody single variable domain.
Patent CY-1109555-T1 (CY)
Inventor: POWELL FRANCIS R
IPC: H05K3/32
Filed: 2009-12-01
Abstract: A microcurrent therapy device (MCTD) for use in applying a DC current of less than one milliampere between two conductive pads through the tissue of a therapy recipient has an electronic stack that can be placed in electrical connection with the user's skin and thus in electrical connection with the other skin contact plate, a profile minimizing system using an off the shelf "coin " battery within the electronic stack, and a battery clip used in conjunction with a coin battery and the circuit board of the MCTD.
Patent CY-1109717-T1 (CY)
Inventor: Galli Frédéric
IPC: A61K31/439
Filed: 2010-01-05
Abstract: The invention relates to compounds having general formula (I), wherein R is as defined herein. The invention also relates to acid addition salt, a hydrate or a solvate of compounds of formula (I). The invention further relates to the method of preparing said compounds and to the use of same in therapeutics.
Patent CY-1110138-T1 (CY)
Inventor: HU YUN-FU
IPC: C12Q1/56
Filed: 2010-06-21
Abstract: This invention relates to a method for determining the activity of Lp-PLA2 in a plurality of samples from animals. The invention also relates to a kit for determining Lp-PLA2 activity in a plurality of samples.
Patent CY-1110749-T1 (CY)
Title: Νεα παραγωγα ξανθινης, παραγωγη αυτων και χρηση τους ως φαρμακων
Inventor: HIMMELSBACH FRANK
IPC: C07D473/04
Filed: 2010-08-20
Abstract: Η παρούσα εφεύρεση αφορά υποκατεστημένες ξανθίνες του γενικού τύπου (I), στον οποίο τα R1 έως R4 ορίζονται όπως στην αξίωση 1, τα ταυτομερή τους, τα στερεοϊσομερή τους, τα μείγματα τους, τα προφάρμακά τους και τα άλατα τους, τα οποία έχουν πολύτιμες φαρμακολογικές ιδιότητες, ιδιαιτέρως ανασταλτική δράση στη δραστικότητα του ενζύμου διπεπτιδυλ-πεπτιδάση-IV (DPP-IV).
Patent CY-1110843-T1 (CY)
Inventor: XU WENFENG
IPC: C07K16/28
Filed: 2010-10-18
Abstract: The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
Patent CY-1112417-T1 (CY)
Title: Παραγωγα 2-οξο-αλκυλο-1-πιπεραζιν-2-ονης, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη
Inventor: BARONI MARCO
IPC: C07D401/14
Filed: 2012-02-29
Abstract: Η παρούσα εφεύρεση έχει ως αντικείμενο τα παράγωγα των παραγώγων της 4-{2-[φαίνυλο-3,6- διυδρο- πυριδιν-1 -υλ]-2- όξο- άλκυλο}-1- πιπεραζιν-2- όνη και 4-{2-[φαίνυλο-2,5- δίυδρο- πυρρολ-1- υλ]-2- όξο- άλκυλο}-1- πιεραζιν-2- όνη του γενικού τύπου (Ι) όπου τα Α, Β, m, R3 και η είναι όπως ορίζονται στην αξίωση 1, την παρασκευή τους και την εφαρμογή τους στη θεραπευτική.
Patent CY-1114625-T1 (CY)
Title: Rapamycin προς χρηση στην καταστολη ή προληψη του χοριοειδους νεοαγγειακου δικτυου
Inventor: LATIES ALAN
IPC: A61K31/436
Filed: 2013-10-07
Abstract: Η παρούσα εφεύρεση σχετίζεται με συνθέσεις και μεθόδους για την καταστολή της ανεπιθύμητης αγγειογένεσης, ειδικότερα αυτής των οφθαλμικών ιστών. Παρέχεται θεραπεία, καταστολή, και/ή πρόληψη του χοριοειδούς νεοαγγειακού δικτύου (CNV), μαζί με ένα ζωικό μοντέλο του CNV και τεχνικές απεικόνισης που επιτρέπουν την διαλογή πιθανών παραγόντων σαν παραγόντων αντί-αγγειογένεσης και παραγόντων αντί-CNV.
Patent CY-1115824-T1 (CY)
Title: Trichoderma atroviride για to βιοελεγχο των προσβολων απο μυκητες σε φυτα
Inventor: PERTOT ILARIA
IPC: A01N63/38
Filed: 2014-12-17
Abstract: Μία εφαρμογή της παρούσας εφεύρεσης είναι ένα Trichoderma atroviride SC1, CBS n°122089, ως ένας παράγοντας βιοελέγχου, δηλαδή για την καταπολέμηση των προσβολών από μύκητες σε φυτά. 122089, ως ένας παράγοντας βιοελέγχου, δηλαδή για την καταπολέμηση των προσβολών από μύκητες σε φυτά. Η δεύτερη εφαρμογή της παρούσας εφεύρεσης είναι μία γεωργική σύνθεση η οποία περιέχει το Trichoderma atroviride SC1 ως δραστικό συστατικό σε μία αποτελεσματική ποσότητα. Οι συνθέσεις της παρούσας εφεύρεσης μπορεί να περιέχουν περαιτέρω ένα δεύτερο παράγοντα βιοελέγχου ή/και μία πρόσθετη ύλη, ένα γαλακτωματοποιητή, μία θρεπτική ύλη φυτών, έναν παράγοντα διαβροχής, ένα θρεπτικό ιχνοστοιχείο φυτών ή ένα υπόστρωμα, όπου το εν λόγω υπόστρωμα επιλέγεται από την ομάδα η οποία απαρτίζεται από: ένα θρεπτικό μέσο καλλιέργειας, ένα δημητριακό ή ένα παράγωγο του, ένα βελτιωτικό, ένα φυτό ή ένα μέρος του, τύρφη, ξύλο ή ένα τεμάχιο του, άργιλο ή φλοιούς.
Patent CY-1116043-T1 (CY)
Title: Κρυσταλλικες μορφες υδροχλωρικου αλατος (4α-r,9α-s)-1-(1η-βενζοϊμιδαζολο-5-καρβονυλ)2,3,4,4α,9,9α-εξαϋδρο-1η-ινδενο[2,1-β]πυριδινο-6-καρβονιτριλιου και χρηση τους ως αναστολεις της hsd 1
Inventor: ECKHARDT MATTHIAS
IPC: A61K31/435
Filed: 2015-02-25
Abstract: Η παρούσα εφεύρεση αναφέρεται σε κρυσταλλικές ενώσεις του ακόλουθου δομικού τύπου (II) που κατέχουν πολύτιμη φαρμακολογική δραστικότητα. Συγκεκριμένα, οι ενώσεις είναι αναστολείς της 11 β-υδροξυστεροειδικής αφυδρογονάσης (HSD) 1 και όθεν είναι κατάλληλες για τη θεραπεία και πρόληψη νόσων οι οποίες μπορούν να επηρεαστούν από την αναστολή αυτού του ενζύμου, όπως μεταβολικές νόσοι, ιδιαίτερα διαβήτης τύπου 2, παχυσαρκία, και δυσλιπιδαιμία.
Patent CY-1120853-T1 (CY)
Title: Πασσαλος αγκυρωσης με ουσιαστικα κυλινδρικο αξονα
Inventor: SATLOW ROLAND
IPC: E02D7/02
Filed: 2018-06-27
Abstract: Πάσσαλος αγκύρωσης (1), με ουσιαστικά έναν κυλινδρικό άξονα (2), όπου ο άξονας (2) σχηματίζει ένα πρώτο άκρο πασσάλου (1a) και ένα δεύτερο άκρο πασσάλου (1b), όπου στον πάσσαλο αγκύρωσης (1) στην περιοχή του δεύτερου άκρου πασσάλου (1b) είναι διατεταγμένη μια μούφα (3), όπου η μούφα (3) ή ο πάσσαλος αγκύρωσης (1) στην περιοχή του δεύτερου άκρου πασσάλου (1b) έχει έναν αναστολέα (9), έτσι ώστε ένας περαιτέρω πάσσαλος αγκύρωσης (1) με ένα πρώτο άκρο πασσάλου (1a) να μπορεί να εισαχθεί σε ένα καθορισμένο μέγιστο βάθος εισαγωγής (Τ) που καθορίζεται μέσω του αναστολέα (9), όπου η μούφα (3) και/ή ο πάσσαλος αγκύρωσης (1) στην περιοχή του δεύτερου άκρου πασσάλου (1b) στο εσωτερικό σχηματίζει ή σχηματίζουν μία τουλάχιστον οπίσθια εγκοπή (8), που εκτείνεται ουσιαστικά τουλάχιστον μέχρι τον αναστολέα (9).
Patent CY-1123765-T1 (CY)
Title: Μεταλλικο συμπαγες βλημα, διαταξη εργαλειων και μεθοδος για την παραγωγη μεταλλικων συμπαγων βληματων
Inventor: SPANNER FLORIAN
IPC: F42B12/34
Filed: 2020-09-24
Abstract: Μεταλλικό συμπαγές βλήμα (1) για εκπαιδευτικά φυσίγγια κυρίως για χρήση από σκοπευτήρια της αστυνομίας κατά προτίμηση, όπου το συμπαγές βλήμα περιλαμβάνει ένα μετωπικό τμήμα αψιδίου (3) και ένα κυλινδρικό τμήμα (5) για τη συγκράτηση του μεταλλικού βλήματος σε ένα χιτώνιο φυσιγγίου και κατά την αξονική διεύθυνση ορίζει ένα μήκος βλήματος, όπου το τμήμα αψιδίου έχει ένα τοίχωμα αψιδίου (31) και μια οριοθετούμενη περιμετρικά από το τοίχωμα αψιδίου, περιστροφικά συμμετρική κοιλότητα αψιδίου (33), όπου προβλέπεται ένα πλήρως κυλινδρικό τμήμα κορμού του συμπαγούς βλήματος το οποίο εκτείνεται κατά την αξονική διεύθυνση σε λιγότερο από το 45% του μήκους του βλήματος.
Patent HR-P20110259-T1 (HR)
Title: Connecting element for c-shaped profiled members, comprising a compensating means, and arrangement
Inventor: KNAUF ALFONS JEAN
IPC: E04B9/16
Filed: 2011-04-11
Abstract: The connector element (1) for dry-joint structures comprises two sides, catches (3) and a holding section (4) which at least in the transition zone (6) is provided with a compensating device (5). An independent claim is also included for an arrangement consisting of two channel profiles joined by means of the proposed connector element.
Patent HR-P20110866-T1 (HR)
Title: Prefabricated building unit
Inventor: BANA SANDRO
IPC: E04B1/348
Filed: 2011-11-21
Abstract: A prefabricated building unit (1) comprising a rigid structure formed by tubular posts (2,2a) and beams (3) making a cage, at least part of said posts (2a) being arranged at the angles of said structure, wherein an angular section bar (5) configured to define a dihedral angle facing the inside of the structure is associated with each tubular post (2a) arranged at the angle.
Patent SI-2014285-T1 (SI)
Title: NPYY5 antagonists
Inventor: KAWANISHI YASUYUKI
IPC: A61K31/00
Filed: 2000-11-21
Abstract: Neuropeptide Y5 receptor antagonist comprises new or known aminosulfinyl or aminosulfonyl derivatives (I). Neuropeptide Y5 receptor antagonist comprises aminosulfinyl or aminosulfonyl derivatives of formula (I), their prodrugs, salts or solvates. [Image] R 1optionally substituted lower alkyl, cycloalkyl or aryl, or R 1 + R 2lower alkylene; n : 1 or 2; X : (CR 3R 4) pA(CR 5R 6) q, HetU, NR 2X or optionally substituted lower alkylene, lower alkenylene, CO-lower alkylene or CO-lower alkenylene; A : optionally substituted cycloalkylene, cycloalkenylene, bicycloalkylene, arylene or divalent heterocycle; p, q : 0 or 1; Het : piperidinediyl, piperazinediyl, pyridinediyl, pyrazinediyl, pyrrolidinediyl or pyrrolediyl all attached to NR 2 via N; U : a bond, lower alkylene or lower alkenylene; Y : OCONR 7, CONR 7, CSNR 7, NR 7CO or NR 7CS; R 2-R 7H or lower alkyl; Z : optionally substituted lower alkyl, lower alkenyl, amino, lower alkoxy, carbocyclyl or heterocyclyl. Independent claims are also included for compounds (I), their salts, prodrugs and solvates in which: (i) X = 2-6C alkylene or 3-6C alkenylene; and R 1 = optionally substituted 3-10C alkyl or 5 or 6C cycloalkyl; provided that when Y = NR 7, the Z is not lower alkylphenylamino, lower hydroxyalkylphenylamino or acylphenylamino; (ii) A = heteroarylene or optionally substituted cycloalkylene, cycloalkenylene, bicycloalkylene or piperidinylene; and R 1 = optionally substituted 3-10C alkyl or 5 or 6C cycloalkyl; and (iii) A = p-phenylene; R 1 = 3-10C alkyl or 5 or 6C cycloalkyl and Z = p-lower alkylphenylene; provided that when R 1 = isopropyl, the Z is not p-n-butylphenylene. ACTIVITY : Anorectic; antidiabetic; hypotensive; antilipemic; antiarteriosclerotic; cardiant. MECHANISM OF ACTION : Neuropeptide-Y5 antagonist. In assays, a compound of formula (Ia) exhibited IC 50 values for neuropeptide Y5 binding of 0.1 nM and for cAMP in Chinese hamster ovary cells of 1.9 nM. [Image].
Patent SI-1228757-T1 (SI)
Title: Stable pharmaceutical solutions of nimesulide
Inventor: TSETIS KLEON
IPC: A61K31/18
Filed: 2001-06-05
Abstract: This invention relates to stable pharmaceutical solutions of Nimesulide, consisting of 80% Glycerol formal, 15% Ethanol and 5% Water and/or 75% Glycerol formal, 10% Ethanol, 10% Propylene glycol and 5% Water. These solutions are suitable for the preparation of parenteral pharmaceutical formulations, destined to therapeutic purposes.
Patent SI-1576182-T1 (SI)
Title: Product quality enhancement in mammalian cell culture processes for protein production
Inventor: SCHILLING BERNHARD M
IPC: C07K14/705
Filed: 2003-12-18
Abstract: The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, illustratively, but not limited to, fed-batch cell cultures. The methods comprise feeding the cells with D-galactose, preferably with feed medium containing D-galactose, preferably daily, to sustain a sialylation effective level of D-galactose in the culture for its duration, thus increasing sialylation of the produced proteins. The methods can also comprise at least two temperature shifts performed during the culturing period, in which the temperature is lower at the end of the culturing period than at the time of initial cell culture. The cell culture processes of the invention involving two or more temperature shifts sustain a high cell viability, and can allow for an extended protein production phase. The methods can also comprise the delayed addition of polyanionic compound at a time after inoculation. Supplementation of the cultures with D-galactose, preferably in a feed medium, to sustain galactose at sialylation effective levels in the cultures until the end of a culture run reverses a decline in sialylation that accompanies culture scale up, and is advantageous for large scale culturing processes.
Patent SI-1946776-T1 (SI)
Title: Stabilized tnfr-fc composition comprising arginine
Inventor: GOMBOTZ WAYNE R
IPC: A61K39/00
Filed: 2003-02-27
Abstract: The present invention relates to an aqueous pharmaceutical composition suitable for long-term storage of polypeptides containing an Fc domain of an immunoglobulin, methods of manufacture, methods of administration and kits containing same.
Patent SI-1987012-T1 (SI)
Title: Reduction of 5-(aryl-diazenyl)-4,6-dihalo-pyrimidine
Inventor: QUITTMANN WILHELM
IPC: C07D239/00
Filed: 2007-02-13
Abstract: Method of synthesizing a compound of formula (I), wherein R1, R2 are, independently, chloro or fluoro, and wherein R3 is H, alkyl, aralkyl or is an alkylether or alkylthioether comprising the steps of firstly reducing a diazeny compound of formula (II) non-catalytically or with a catalytic amount of an homogenous organic, non-metal catalyst to the corresponding hydrazo compound of formula (III) and in a second step catalytically hydrogenating said hydrazo compound in with a heterogeneous Ni-catalyst to the compound of formula (I).