baber/WOPTO huggingface dataset:
Patent JP-3376561-B2 (JP)
IPC: C02F3/28
Filed: 1993-06-10
Granted: 2003-02-10
Abstract: PCT No. PCT/NL93/00125 Sec. 371 Date Dec. 12, 1994 Sec. 102(e) Date Dec. 12, 1994 PCT Filed Jun. 10, 1993 PCT Pub. No. WO93/25485 PCT Pub. Date Dec. 23, 1993.A system for purifying nitrogenous waste water by biological nitrification and denitrification, comprises at least two essentially separated reactor chambers, a liquid supply (4) and a liquid discharge (5). The first, aerated reactor chamber (1) is provided at the top with an overflow to the second, oxygen-depleted reactor chamber (2). The oxygen-depleted reactor chamber (2) is divided at the top into a degassing chamber (7) and a settling chamber (8) having an overflow (9) to the liquid discharge. The first reactor chamber is provided with an air supply (11, 18) and an air discharge (12) located above the supply. The first reactor chamber may be partly divided into a riser (14) and a downcomer (15) which allow, as a result of the air supply, mass circulation to take place in the aerated reactor chamber. According to the process, waste water with bacterial sludge on a carrier circulates alternately through the oxygen-depleted and the aerated reactor chambers, whereafter it is separated from the sludge and the sludge is returned to the reactor.
Patent JP-3601606-B2 (JP)
IPC: G01N21/78
Filed: 1996-06-06
Granted: 2004-12-15
Abstract: The present invention relates to single and dual-reporter luminescence assays utilizing general and specific reagents to quench enzyme-mediated reactions. In one embodiment of the invention, a reagent is added to the assay which non-specifically quenches enzyme-mediated luminescent reactions. In another embodiment of the invention, a reagent is added to the assay which simultaneously quenches one enzyme-mediated luminescent reaction while activating another distinct enzyme-mediated luminescent reaction. An assay kit containing specific quench reagents, and the reagents themselves are also disclosed.
Patent JP-H0662574-B2 (JP)
IPC: C07D403/04
Filed: 1988-03-24
Abstract: Disclosed herein are novel 1-substituted-2,3,4,5-tetrahydro-1H-3-benzazepines of the general formula I: <CHEM>  wherein R<1>, R<2>, R<3>, R<4> and R<5> are specified substituents.    R<1> is preferably -X<6>, -CHR<7>R<8>, cycloalkyl, cycloalkenyl, <CHEM> or pyrrolyl where m is 1, R<6> represents =H, phenyl, substituted phenyl, aralkyl, alkyl, cycloalkyl, haloalkyl or alkoxyalkyl, R<7> represents H or alkyl preferably H, R<8> represents cycloalkyl, cycloalkenyl, haloalkyl, alkoxyalkyl, alkenyl or alkynyl and R<9> represents alkyl, alkoxy or alkoxyalkyl.   R<2> preferably represents -H and R<3> -CH3, R<4> is preferably halogen and R<5> is preferably OH, OCO<.>R<9> or -O(CR<7>)2<.>OCO<.>R<1><3> where R<7> represents hydrogen, R<9> is as defined above and R<1><3> represents alkyl. The compounds of the formula I are indicated as being useful in the treatment of psychoses, depression and pain. Also disclosed are process for the preparation of the novel compounds as well as pharmaceutical compositions comprising them.
Patent JP-2704672-B2 (JP)
IPC: G01J5/00
Filed: 1991-12-11
Granted: 1998-01-26
Abstract: PCT No. PCT/US91/09404 Sec. 371 Date Mar. 11, 1992 Sec. 102(e) Date Mar. 11, 1992 PCT Filed Dec. 11, 1991.A body temperature thermometer has a probe head assembly (8) which includes a first sensor (10), such as a thermopile, for generating a first output signal representative of an amount of infrared radiation impinging thereon The probe head assembly further includes a waveguide (16) and a surrounding hollow probe (14) for receiving infrared radiation emitted by a biological surface tissue, such as the external ear canal and tympanic membrane of a patient, and directing the radiation to the first sensor. A second sensor (12) is mounted in the probe head assembly for generating a second output signal representative of a temperature of the first sensor. A third sensor (26) is thermally coupled to the waveguide for providing a third output signal representative to the temperature thereof. A processor (30) is connected to the sensors for processing the output signals to determine a body temperature of the patient utilizing a calibration mapping of a plurality of target temperatures to corresponding output signals taken over a predetermined range of ambient temperatures. A display (34) is driven by the processor for providing a user with a visual indication of the determined body temperature.
Patent JP-3942640-B2 (JP)
IPC: A61M31/00
Filed: 1997-07-03
Granted: 2007-07-11
Abstract: A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.
Patent JP-H0813742-B2 (JP)
IPC: A61P7/02
Filed: 1986-09-19
Abstract: PCT No. PCT/EP86/00545 Sec. 371 Date May 19, 1987 Sec. 102(e) Date May 19, 1987 PCT Filed Sep. 19, 1986 PCT Pub. No. WO87/01591 PCT Pub. Date Mar. 26, 1987.Taurolin compounds are used as blood coagulation-inhibiting agents and as abacterial inflammation-inhibiting agents. The outstanding coagulation-inhibiting action of taurolin is especially suitable for use in medical conditions requiring dialysis and for vascular protheses. These compounds can also be used together with other anti-coagulants such as coumarin or heparin.
Patent JP-2886533-B2 (JP)
IPC: C08G59/36
Filed: 1987-08-14
Granted: 1999-04-26
Abstract: The invention concerns a coupled aromatic compound represented by the formula  Ar - Y      I wherein Ar is an aromatic moiety different from Y and Y is an aromatic moiety represented by one of the formulae: <CHEM>  wherein A is an aliphatic ring system bonded to the aromatic ring; Q is separately at each occurrence hydrogen, alkyl or inertly substituted alkyl with proviso that the carbon atom bonded to the aromatic ring is a primary or secondary carbon atom,  X is separately at each occurrence a halogen moiety, Z is a nitrogen- or chalcogen-containing moiety, and their preparation. The materials contain a moiety such as, for example, 4-oxy-3,5-dimethyl-2,6-dibromobenzyl which can impart a high degree of thermal and hydrolytic stability to the materials, for example, epoxy thermosets such as in electronic encapsulations. For example, when used in electronic encapsulation formulations, these materials can provide a substantial increase in electronic device reliability. Their preparation involves an alkylation of an aromatic ring, for example, such as a Friedel-Crafts alkylation with 4-bromomethyl-3,5-dibromo-2,6-dimethylphenol or with 4-hydroxymethyl-3,5-dibromo-2,6-dimethylphenol.
Patent JP-3616089-B2 (JP)
IPC: C12Q1/68
Filed: 1992-08-28
Granted: 2005-02-02
Abstract: The invention provides a method of identifying a tissue source of epithelial cells that express a cellular gene encoding a polypeptide, the amino acid sequence of which comprises  (I) a sequence having at least 70% amino acid sequence homology with the C-terminal seven-cysteine domain of human OP-1, residues 38-139 of SEQ ID No. 5, or (II) a sequence defined by generic sequence 6, SEQ ID No. 31, said polypeptide, when dimerized with a second said polypeptide, forming a protein having the property of inducing a developmental cascade of tissue-specific morphogenesis in a mammal, said method further being a method of screening a candidate compound for the ability to modulate expression of said gene, said method comprising the steps of:  (a) incubating at least two preparations comprising epithelial cells derived from at least two different tissues of an organism with a compound shown to modulate expression of said gene for a time sufficient to allow said compound to affect the expression of said gene; (b) assaying said at least two preparations of cells for the presence or amount of an expression product of said gene, wherein a change in the level of said expression product relative to the level thereof in said at least two preparations of cells in the absence of said compound identifies cells wherein a change occurred as a tissue source of epithelial cells suitable for screening a candidate compound for the ability to modulate expression of said gene; (c) incubating said candidate compound with epithelial cells cultured from the tissue source for which a change in the level of gene expression was observed in step (b), for a time sufficient to allow said candidate compound to affect the expression of said gene; and (d) assaying said cultured epithelial cells for the presence or amount of an expression product of said gene, wherein a change in the level of said expression product relative to the level thereof in said cultured epithelial cells in the absence of said candidate compound is indicative of the ability of said compound to modulate expression of said gene in said cultured epithelial cells.
Patent JP-3281379-B2 (JP)
IPC: A61K9/00
Filed: 1992-10-09
Granted: 2002-05-13
Abstract: A stick-like holder and packaging, including an overcap and a sealed, light, moisture and tamper resistant foil pouch, for a hardened, medicated matrix affixed to one end of the holder including detent means for releaseably mounting the overcap on the matrix end of the holder and with the holder having a flat, label receiving handle at its other end and a flange to prevent swallowing of the holder when placed in a patient's mouth to medicate or pre-medicate the patient.
Patent JP-4317923-B2 (JP)
IPC: G01R25/08
Filed: 1998-06-29
Granted: 2009-08-19
Abstract: A circuit (10) for determining periods of and the phase relationship between waveform signals (28 and 30). A delay line (12) having a sample port (14), a set port (16), a reference port (18), and an output port (20) and further internally including a chain of delay elements (32) associated with latch elements (34) and an encoder (36). The delay line (12) receive a first signal (28) into the sample port (14), and via a switch (22) also into the set port (16). The encoder (36) then provides the period of the first signal (28) at the output port (20) of the delay line (12) in units of delay created by each delay element (32). A control unit (24) then operates the switch (22) to direct a second signal (30) into the set port (16) for comparison with the first signal (28) at the sample port (14), and values are obtained at the output port (20) relating edges of a cycle in the second signal (30) to edges of the first signal (28), from which period of the second signal (30) and the phase relationship between the signals (28 and 30) is calculated with an arithmetic unit (26).
Patent JP-2995707-B2 (JP)
IPC: G01B11/27
Filed: 1992-02-21
Granted: 1999-12-27
Abstract: A high speed high precision laser based alignment sensor system for use on surface mount component placement machines. A laser system is utilized to correctly align and position component parts which range between 0.02 inches and 2.0 inches in size. The laser sensor system consists of a laser light source which is passed through a collimating lens and then through an aperture to create a stripe of collimated laser light which is focused past the component being aligned to strike a multi-element CCD sensor array. The sensor system is mounted directly on the carrying mechanism for the surface mount component placement machine. During transit of the component between the bin of components is to be placed, the component is rotated and the shadow which falls on the detector array is monitored. When the minimum width of shadow is detected, the correct angular orientation is determined, the average of the edges of the shadow when compared with the center of the quill determines the coordinate (X,Y) location of the component on the quill. Two alignments normally occur displayed by 90°. Thereafter, the sensor sends correcting signals to the component placement machine to assure the correct angular orientation and the correct X,Y position for the component to be placed on the circuit board by the component placement machine.
Patent JP-3756945-B2 (JP)
IPC: A61K8/365
Filed: 1993-10-26
Granted: 2006-03-22
Abstract: An antibacterial oral hygiene composition in aqueous form comprising: (a) from about 0.05% to about 0.2% by weight of sodium benzoate; (b) from about 0.01% to about 1.0% by weight of a weak carboxylic acid; (c) from about 2.0% to about 5.0% by weight of a buffering agent capable of buffering the composition to a pH of about 3.0 to about 8.0; (d) from 0% to about 1.5% by weight of a surfactant; (e) from 0% to about 0.2% by weight of sodium saccharin, or an amount sufficient to provide a sweetening effect equivalent thereto of a sweetening agent; (f) from 0% to about 2.0% by weight of a flavoring agent; and (g) sufficient water to total 100%.
Patent JP-4162265-B2 (JP)
IPC: C08F8/30
Filed: 1997-08-29
Granted: 2008-10-08
Abstract: The invention concerns cross-linked copolymers with a base of non cross-linked polycarboxylic polymers, said copolymers containing at least one polycarboxylic polysaccharide. The invention also concerns a method for preparing these copolymers and their use in particular as support in pharmaceutical compositions.
Patent JP-2914397-B2 (JP)
IPC: F16H48/10
Filed: 1994-10-25
Granted: 1999-06-28
Abstract: In a vehicle with two axles (12), each of which has at least one drivable wheel (11), each drivable wheel (11) is driven by a hydraulic motor (9) connected to a hydraulic source (6), and the driving power of each hydraulic motor (9) is transmitted to the respective wheel (11) by way of a step-up transmission (10, 35). The drivable wheels (11) are initially all driven with the same, first transmission ratio of the step-up transmission (10, 35). When a first limiting load is reached, the drive to the wheels of one axle (12) is reduced and when a second limiting load is reached, the transmission ratio of the step-up transmission (10, 35) is changed and the wheels which were driven before the first limiting load was reached are again driven equally. <IMAGE>
Patent JP-2504659-B2 (JP)
IPC: A61K31/415
Filed: 1991-06-12
Granted: 1996-06-05
Abstract: This invention relates to novel 3-(1-substituted-pyrazoyl)-2-oxindole derivatives which are inhibitors of prostaglandin H2 synthease, 5-lipoxygenase and interleukin-1 biosynthesis. The compounds of the invention are useful as inhibitors of prostaglandin H2 synthase and interleukin-1 biosynthesis, per se, and as analgesic, antiinflammatory and antiarthritic agents in the treatment of chronic inflammatory diseases. This invention also relates to pharmaceutical compositions comprising said 3-(1-substituted-pyrazoyl-2-oxindole derivatives; to methods of inhibiting prostaglandin H2 synthase and biosynthesis of interleukin-1; and to treating chronic inflammatory diseases in a mammal with said compounds. Further, this invention relates to certain novel compounds useful as intermediates in the preparation of the 3-(1-substituted-pyrazoyl-2-oxindole derivatives of this invention and to a process for the preparation of the 3-(1-substituted-pyrazoyl)-2-oxindole derivatives.
Patent JP-2592560-B2 (JP)
IPC: A61M13/00
Filed: 1991-08-13
Granted: 1997-03-19
Abstract: PCT No. PCT/EP91/01531 Sec. 371 Date Apr. 23, 1993 Sec. 102(e) Date Apr. 23, 1993 PCT Filed Aug. 13, 1991 PCT Pub. No. WO92/04067 PCT Pub. Date Mar. 19, 1992.The invention relates to a propellent-free inhalation device having a supply of solidified medicinal substance to be inhaled, a manually operable metering device for removing a given dose of the medicinal substance for the inhalation process and having a mouthpiece for actively breathing in and an air space for distributing the particular dose of medicinal substance in the air stream. An abrasion device, in the form of a brush comprising a plurality of bristles, is used to abrade the medicinal substance to form the dose.
Patent JP-3785423-B2 (JP)
IPC: C08F4/606
Filed: 1994-12-13
Granted: 2006-06-14
Abstract: PCT No. PCT/EP94/04125 Sec. 371 Date Jun. 26, 1996 Sec. 102(e) Date Jun. 26, 1996 PCT Filed Dec. 13, 1994 PCT Pub. No. WO95/18160 PCT Pub. Date Jul. 6, 1995Homopolymers of ethylene or copolymers of ethylene with other olefins or mixtures thereof are prepared by suspension polymerization in the presence of catalyst systems by a process in which the catalyst systems used are those which contain, as active components, A) a finely divided carrier treated with trialkylaluminum, B) a metallocene complex, C) an open-chain or cyclic alumoxane compound and D) an alkali metal alkyl or alkaline earth metal alkyl or a mixture thereof.
Patent JP-3731607-B2 (JP)
IPC: A61K47/00
Filed: 1994-12-22
Granted: 2006-01-05
Abstract: PCT No. PCT/EP94/04288 Sec. 371 Date Aug. 26, 1996 Sec. 102(e) Date Aug. 26, 1996 PCT Filed Dec. 22, 1994 PCT Pub. No. WO95/17883 PCT Pub. Date Jul. 6, 1995The application is directed to a water-in-oil lotion containing hydrocotisone-21-acetate-17-propionate and one of four compositions containing a water-in-oil emulsion. The lotion is suitable for use on dry skin, it has good spreadability on large surface areas and it is dermatologically acceptable.
Patent JP-4044144-B2 (JP)
IPC: B65D50/04
Filed: 1997-10-17
Granted: 2008-02-06
Abstract: The closure cap for sealing a container has an inner skirt shaped and sized to fit externally and to be secured onto the neck of the container. The cap also has an outer skirt projecting from the inner skirt. This outer skirt extends over the inner skirt at a given distance from same, thereby defining a gap there between. The outer skirt is made of a material that is resiliently flexible and can be deformed when an external pressure is applied onto its external surface. The cap further has a foldable cover shaped and sized to close the neck of the container. This cover has a peripheral edge attached to the outer skirt by a hinge. A snap having one part integral to the upper portion of the other skirt and another part integral to the cover is provided for releasably locking the cover in a closed position when it is folded down over the neck of the container. The one part of the snap that is integral to the upper portion of the outer skirt is positioned and devised to move and disengage the other part of the snap means and thus release the cover, when external pressure is applied at a suitable location onto the external surface of the outer skirt.
Patent JP-3425149-B2 (JP)
IPC: A61K39/00
Filed: 1994-04-08
Granted: 2003-07-07
Abstract: Assays for identifying human patients at risk for developing insulin-dependent diabetes mellitus rely on detection of autoantibodies to a 38 kD autoantigen present in pancreatic beta-cells in patient sera. It has been found that autoantibodies to this particular autoantigen developed in patients well before clinical onset of the disease in a significant subpopulation of prediabetic patients. Useful assays will frequently combine detection of autoantibodies to the 38 kD autoantigen with detection of other known markers of IDDM, such as autoantibodies to a 64 kD autoantigen (glutamic acid decarboxylase).
Patent JP-4144762-B2 (JP)
IPC: A61L31/04
Filed: 1997-11-28
Granted: 2008-09-03
Abstract: The present invention provides a microfistula tube including a soluble duct, defining a drainage canal having an inner surface, the duct being biocompatible, wherein the microfistula tube is coated with and/or incorporates biological for forming a basement membrane, or an intracellular matrix and a basement membrane. The biological cells may coat the inner surface of the drainage canal, and the microfistula tube may be made of a mouldable material or an absorbable material. The invention also provides an implantation system for the microfistula tube including a microfistula tube and a surgical instrument including an outer tube for penetrating body tissue, an inner tube, and an innermost rod, wherein the outer tube, the inner tube and the innermost rod are coaxial, the outer tube is adapted to receive said microfistula tube, whereby the inner tube may be used to push the microfistula tube into position and the innermost rod provides mechanical support during implantation of the microfistula tube.
Patent JP-4287909-B2 (JP)
IPC: B01J21/06
Filed: 1997-12-09
Granted: 2009-07-01
Abstract: Olefinically unsaturated hydrocarbons are prepared from corresponding paraffinic hydrocarbons, in particular propylene is prepared from propane, by dehydrogenation over a catalyst comprising an oxide of a transition metal of group IV B of the Periodic Table, eg. TiO<SUB>2 </SUB>or ZrO<SUB>2</SUB>, and possibly at least one element selected from among elements of transition group VIII, eg. palladium, platinum or rhodium, and/or an element of transition group VI, eg. chromium, molybdenum or tungsten, and/or rhenium and/or tin and possibly a compound of an alkali metal or alkaline earth metal, a compound of main group III or transition group III or zinc.
Patent JP-4519950-B2 (JP)
IPC: H01M8/1004
Filed: 1998-05-08
Granted: 2010-08-04
Abstract: The invention relates to a method for producing an electrolyte unit with a catalytically active coating. Dissolved metal salt (2) is placed in the form of a coating between an electrolyte coating (1) and an electrode (3) and metal is electrochemically separated from the metal salt. One advantage of the invention is that no expensive electroplating baths are required for production. The catalytically active metal is deposited in targeted manner on the three phase zone, thereby minimizing the use of expensive precious metals. The electrolyte unit can, for example, be used in fuel cells.
Patent ES-2259519-B2 (ES)
Title: Sistema de autentificacion por espectro concreto.
Inventor: GUTIERREZ MIGUELEZ ANGEL
IPC: G11B7/24
Filed: 2004-10-07
Granted: 2007-12-01
Abstract: Sistema de autentificación por espectro concreto. La invención consiste en un detector de espectros concretos obtenidos a partir de una iluminación láser monocromada que identifica marcas espectrales presentes en objetos originales. Todo ello realizado en los materiales y con las técnicas adecuadas que favorezcan el aprovechamiento de la energía en cada caso.
Patent ES-2531189-B2 (ES)
Title: Procedimiento de cuantificación de la opacidad ocular de una lente intraocular
Inventor: RUIZ FERNANDEZ DANIEL
IPC: A61B3/10
Filed: 2013-08-05
Granted: 2015-12-18
Abstract: Procedimiento de cuantificación de la opacidad ocular de una lente intraocular.#El grado de opacificación de la cápsula posterior se determina, en la mayoría de los casos, de forma subjetiva mediante la valoración de un especialista que observa el estado de la cápsula situada detrás del cristalino y la visión descrita por el mismo paciente. En esta invención se presenta un procedimiento para detectar las células que se pueden generar entre la cápsula posterior (envoltura del cristalino) y una lente intraocular, pudiendo, de esta forma, cuantificar la opacificación producida. Este procedimiento de cuantificación del grado de opacidad en la lente intraocular incorpora varias etapas que dotan de un elevado grado de automatismo al procedimiento: se detecta automáticamente el área de interés, se detectan zonas que pueden falsear el análisis para no incluirlas en la cuantificación, se detectan las células consecuencia de la opacidad en la lente y, finalmente, se cuantifica la superficie de la lente que presenta un problema de opacidad.