baber/WOPTO huggingface dataset:
Patent SG-11201906386X-A (SG)
Title: Combination therapy involving diaryl macrocyclic compounds
Inventor: CUI JINGRONG
IPC: A61K31/439
Filed: 2018-01-25
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 August 2018 (02.08.2018) WIP0 I PCT °Ens °nolo olomollm voimiflo oimIE (10) International Publication Number WO 2018/140554 Al (51) International Patent Classification: CO7D 498/18 (2006.01) A61K 31/4995 (2006.01) A61K 31/439 (2006.01) (21) International Application Number: PCT/US2018/015150 (22) International Filing Date: 25 January 2018 (25.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/450,455 25 January 2017 (25.01.2017) US 62/619,165 19 January 2018 (19.01.2018) US (71) Applicant: TP THERAPEUTICS, INC. [US/US]; 10628 Science Center Drive, Ste. 225, San Diego, CA 92121 (US). (72) Inventors: CUI, Jingrong, Jean; 10628 Science Center Drive, Ste. 225, San Diego, CA 92121 (US). ZHAI, Day- ong; 10628 Science Center Drive, Ste. 225, San Diego, CA 92121 (US). (74) Agent: LIPTAK, Vincent, P.; Barnes & Thornburg LLP, 11 South Meridian Street, Indianapolis, IN 46204 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: COMBINATION THERAPY INVOLVING DIARYL MACROCYCLIC COMPOUNDS FIG. la 120 O (57) : The present disclosure relates to methods and compositions for treating cancer with a diaryl macrocycle in combination ei with at least one other cancer therapeutic, such as an EGFR inhibitor. [Continued on next page] O WO 2018/140554 Al MIDEDIMODOMMEIE3010MOIRHINIMIIIIIIIII1111111 Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3))
Patent SG-11201908801T-A (SG)
Title: Hinge device for opening and closing a vehicle door
Inventor: PUJOL OLLER JORDI
IPC: E05F15/627
Filed: 2018-04-05
Abstract: The hinge device performs the opening and closing of a door of a vehicle without the door changing orientation. The device comprises an L-shaped arm (2) provided with two ends attached in a pivotable way, around parallel rotation axes, 5 to respective mounting bodies (3, 4), one being fixable to the door and the other to the frame of the vehicle. Each body comprises a concentric pulley body (5, 6) with the respective rotation axis and fixed to a respective mounting body. The device further comprises linking means (7) that extend along the arm and has a path formed by a first segment and a second segment that cross at least once. 10
Patent HU-186219-B (HU)
Inventor: HORVATH GYOEZOENE
IPC: H01J61/36
Filed: 1983-01-12
Abstract: A találmány szerinti megoldással kiküszöbölhetők az ellenálláshegesztési eljárás alkalmazásánál tapasztalt hiányosságok. Eljárásunkat az jellemzi, hogy a kétpontos kötést (7) egyetlen műveletben, legalább az egyik oldalon csőelektródával (8) állítjuk elő. A fólián levő kötési pontok közötti felületszakasz infravörös sugárzásának érzékelésével, melyet alkalmas fotódetektorral (9) végzünk, lehetőség nyílik a hibás hegesztések kiselejtezésére, ill. a fotódetektor jelét vezérlőjelként használva, a hegesztési folyamat szabályozására. (3. ábra)  3. ábra -1-
Patent AT-404143-B (AT)
Title: Apparatus for needling the surface of a nonwoven
IPC: D04H18/00
Filed: 1996-04-19
Granted: 1998-08-25
Abstract: What is described is an apparatus for needling the surface of a nonwoven 1, with at least one needle board 3 which is capable of being driven back and forth transversely to a nonwoven support 2 and of which the needles 5 inserted in each case into separate bores 6 terminate in front of the nonwoven support 2 when the needle board 3 is in the reversal position facing the nonwoven support 2. In order to ensure advantageous needling conditions, it is proposed that the needle board 3 arranged directly opposite the nonwoven support 2 have at least one needle region extending over the working width and possessing a minimum number of five needles 5, preferably of eight needles 5 per cm2. <IMAGE>
Patent HU-189050-B (HU)
Inventor: RASA GERGELY
IPC: E03F5/22
Filed: 1984-02-21
Abstract: A találmány eljárás és berendezés átemelő telepek kapacitásnövelésére vagy ipari létesítmények csatornavizeit befogadóba továbbító átemelő telepek teljesítőképességének fokozására. Az eljárás jellegzetessége, hogy a meglévő átemelő telepen a gravitációsan érkező vizeket ideiglenesen tározzuk, nyomását mesterségesen fokozzuk, és a befogadóba növelt nyomáson továbbítjuk. A berendezés jellegzetessége, hogy az átemelő telep egy vagy több szivattyútere (6, 7) helyett az átemelő műtárgy mellé vannak szivattyúk (24, 25, 26) telepítve, a szivattyúk (24,25,26) szivattyúállásokba (14,15, 18,20) vannak beépítve, a szivattyúállások (14, 15,18, 20) és az átemelő telep eredeti egy vagy több szivatytyútere (6, 7) között összekötő csatornák (13, 17, 19) vannak, az eredeti egy vagy több szivattyútér (6, 7) pedig tároló szerepű elosztótérré van kialakítva.  -1-
Patent HU-192263-B (HU)
Inventor: KATONA LAJOS
IPC: B65G23/44
Filed: 1985-03-04
Abstract: A találmány szerinti kapcsolási elrendezésnek a szállítószalag hajtódobja (HD1) hajtómotorjának (HDM1) áramfelvételét érzékelő, áramcsökkenéssel arányos jelet szolgáltató jelátalakítója (Ál) van, amelynek kimenete különbségképző (KK3) első bemenetére van csatlakoztatva. Á különbségképző (KK3) második bemenetére áramcsökkenés alapjelet szolgáltató egység (-dia) van kötve, kimenete pedig erősítőn (E3) át a feszítőkocsi (FK) mozgás- irányát meghatározó irányváltókapcsoló (FVIK) lazítást kiváltó vezérlő bemenetére (LB) van csatlakoztatva. A hajtódobhoz (HD1) dobsebesség-jeladó (DSJ1), a hevederhez (H) pedig hevedersebesség-jeladó (HSJ) van rendelve, amelyeknek kimenetei további különbségképző (JKK1) egy-egy bemenetére vannak kötve. Ezen különbségképző (JKK1) kimenete erősítőn (El) át az irányváltó kapcsoló (FVIK) feszítést kiváltó vezérlő bemenetére (FB) van csatlakoztatva.  -1-
Patent HU-202634-B (HU)
Inventor: FELLNER OSZKAR
IPC: B60K17/02
Filed: 1989-02-17
Abstract: Die Erfindung bezieht sich auf eine elektromagnetische Kupplung, insbesondere fuer Kraftfahrzeugventilatoren, welche einen an der einen Seite offenen ringfoermigen, feststehenden Magnetkoerper (11) und eine darin angeordnete Elektromagnetspule (10) aufweist, wobei vor der offenen Seite des Magnetkoerpers (11) ein an einer Achse (1) gekeilter Rotorteil (15) angeordnet ist, an dessen dem Magnetkoerper (11) entgegengesetzten Seite zwei umlaufende Nute (29; 30) ausgebildet sind, und neben dem Rotorteil (15) an der dem Magnetkoerper (11) entgegengesetzten Seite ein zweiter Rotorteil (21) angeordnet ist, an welchem mittels Federscheibe (24) ein zwischen den zwei Rotorteilen (15; 21) angeordneter Reibteller (23) aufgehaengt ist. Die erfindungsgemaesze elektromagnetische Kupplung kann dadurch gekennzeichnet werden, dasz die Mittelkreise (d 2; d 3) der im Rotorteil (15) neben dem Magnetkoerper (11) ausgebildeten Nute (29; 30) symmetrisch im Vergleich zum Mittelkreis (d 1) des ringfoermigen Teiles des Magnetkoerpers (11) angeordnet sind und der Abstand (h) zwischen dem Auszenmantel (30 k) der aeuszeren Nut (30) und dem Innenmantel (29 b) der inneren Nut (29) um 0,5 bis 1,0 mm breiter ist als die Breite (vt) zwischen dem Auszenmantel (11 k) und dem Innenmantel (11 b) des Magnetkoerpers * und dasz die Dicke (f) des Bodens (28; 31) der Nute (29; 30) 0,9 bis 1,1 mm betraegt. Fig. 1{Magnetkoerper; Rotorteil; elektromagnetische Kupplung; Mittelkreise; Auszenmantel; Innenmantel; Nut}
Patent LT-4256-B (LT)
Title: The curd product and process for preparing thereof
Inventor: EISS JANIS
IPC: A23C23/00
Filed: 1996-10-02
Abstract: This invention can be used in dairying, namely for producing curd products. Curd products consist of newly made curd of homogenous consistence, cream, a system for stabilising consistence, salt or sugar and taste additive. In the salted version of the product, the ingredients are distributed in the following mass percentages: newly made curd of homogenous consistence - 50-75; cream - 15-30; system for stabilising consistence - 0.5-3.0, salt 0.5-1.5; taste additive 0.1-7. In the sweet version of the product, the ingredients are distributed in the following mass percentages: newly made curd of homogenous consistence - 30-60; cream - 7-25; system for stabilising consistence - 0.5-3.0, sugar 6-25; taste additive - 15-30. The method for producing curd includes the preparation of raw materials, the preparation of a compound of raw materials, mixing thereof, simultaneous homogenisation of the compound by using high-speed knives, pasteurisation in a direct or indirect torrent of steam.
Patent LT-4575-B (LT)
Title: Method for producing of frame-gaskets of an electrodialyzer by casting from thermoplastic material and a casting mould
Inventor: TSKHAI ALEXANDER
IPC: B29C45/26
Filed: 1997-09-24
Abstract: This invention is related to the field of production of thermoplastic material casting and is intended for electrical dialyser gasket frame manufacturing. The point of the invention is that when casting a gasket frame (3) the elements (9) with a hole (4) and cuttings (10) intended for the afterwards cast gasket frame (3) are cast at the same time in the same mould. The elements are put (9) in front of each other in pairs, the hole (4) is put on a projection (5) of the mould (1) and then the gasket frame (3) casting starts, and blanks of elements for the next gasket frame are cast (3) at the same time and in the same mould. The casting mould for the method implementation has a gasket frame (3) matching hollow (2), middle bulge (11), where there are gasket frame (3) elements matching hollows (8), and in those hollows (8) there are projections (12) of the same shape as the projections (5) designed to form the holes (4) of a gasket frame (3), and also oblong projections (13) forming cuttings (10) of gasket frame (3) elements (9), which after putting the elements (9) in pairs in front of each other, form a feed channel. The depth of the hollows (2), that coincide with the elements (9), represents half of the depth (H) of the hollow (2), that coincides with the gasket frame (3), and the height of projections (13) in the hollow (8), that coincides with the gasket frame element (9), does not reach the upper brims of the hollow (8).
Patent LT-3373-B (LT)
Title: Azole derivatives, process for preparing and using thereof
Inventor: WAGNER ADALBERT
IPC: A61K31/40
Filed: 1993-06-25
Abstract: Azole derivatives, which have a general formula (I):<IMAGE>where A, Z, O, R1, X, Y, Z and q have indicated meanings, their extraction method, pharmaceutical preparations and the use of these compounds, as medical substances. The azole derivatives, which have a formula (I), in which the symbols, for example, have these meanings:R<1> - (C2-C10)-alkyl,Z - azote,X, Y - independently from one another, CR<2>,Z - -CH2-,q - 0 or 1,A - biphenyl residue, in which there is a substitute, for example, R<15>,R<2> - halogen or hydrate,R<15> - SO2-NH-CO-R<6> andR<6> - phenylare very effective antagonists of angiotensin-II-receptors.
Patent SE-304448-B (SE)
Inventor: JACKSON J
IPC: F04B49/06
Filed: 1965-01-22
Abstract: 1,060,772. Valves; controlling hydraulic transmissions. VICKERS Ltd.. Jan. 15, 1965 [Jan. 24, 1964]. No. 3257/64. Headings F2D and F2V. [Also in Division G3] A control device for varying the tilt of the swashplate of an hydraulic pump or motor comprises a housing 7, 7A, 7B mounted on the pump or motor 1, a rotary cylindrical control valve 11 for controlling the supply of fluid to and from two pairs of servomotors 6, and valve operating means comprising a manually operated knob 38 and a lever 13 carrying two oppositely wound coils 14, 15 working in the air gap 16 between two U-shaped permanent magnets 17, 18. The valve 11 works between two caps 9, 10 and is integral with a spindle 12. The lower end of the spindle (Figs. 3 and 8) is connected to two spiral springs 26, 27 connected to rotatable members 28, 41, respectively, member 41 also engaging the trunnion 5A of the swashplate 5 whilst member 28 is provided with teeth for engaging a worm connected to the knob 38. The control valve has a chamber 8C supplied with pressure fluid, chambers 8B, 8D each connected to one of the two pairs of servomotors and a chamber 8A connected to exhaust in the pump or motor casing; each of these chambers being provided with a diametrically opposite balancing chamber so that the valve is pressure balanced. In manual operation of the device, knob 38 is rotated and applies a torque to the spindle 12 via spring 26, thereby rotating the control valve and connecting one pair of servomotors to the supply and the other pair to exhaust. Consequent rotation of the swashplate applies a torque to the spindle 12 via spring 27 to return the valve to its neutral position. In electrical operation of the valve a signal is supplied to one of the coils to cause rotation of the valve. Adjustable stops 23 are provided to limit rotation of the valve. The device may control a pump driving a motor the output shaft of which governs the speed or position of a load, and a signal produced in accordance with the speed or position may be compared with a command signal and the difference applied through a pushpull amplifier to either coil. If desired, the output pressure of the pump may act on an hydraulic actuator connected to lever 13, in which case spring 27 may be omitted.
Patent ZA-97181-B (ZA)
Title: A magnetoelectric rotor with claws
Inventor: GUERAUD ALAIN
IPC: H02K1/28
Filed: 1997-01-09
Abstract: The rotor has 2N poles formed by magnetic pieces (1,1') of opposite polarity with N clips. Each clip end (5,5') has a chamfered external surface making a progressive radial air gap and receding internal surfaces that meet at a convergence point at the centre defining a bezel. The clip has a polygonal base which connects with the hub (2) and a tapered free end (8). Several clips are braced by at least one multiple strut in a single piece. In particular, a double strut (7) between the end and the centre of the bezel is used to give a rigid direct link between opposite clips. An annular non-magnetic cover encloses the rotor.
Patent AT-396177-B (AT)
Title: Tubular heat exchanger - has external cowl forming connection between adjacent tubes
IPC: F28F9/02
Filed: 1988-09-30
Granted: 1993-06-25
Abstract: The heat exchanger comprises adjacent and pref. parallel tubes (5) through which a medium flows in succession in alternate directions. The connection between adjacent tubes is formed by an outer wall (1) consisting of a cowl (9) extending over the interior spaces (6) in the adjacent tubes, also an inner wall (2) through which the spaces extend.
Patent FI-52448-B (FI)
Inventor: NORDGREN HANS ELOV
IPC: B65D6/26
Filed: 1973-12-28
Granted: 1977-05-31
Abstract: 1462482 Bending cutters; making fasteners and hinges NEFAB PLYWOODEMBALLAGE AB 9 Jan 1974 [10 Jan 1973] 01022/74 Headings B3W and B3A  Securing tabs 3a, 3b are stamped from sheet metal by co-operation of parallel edges 14, 15 and (16), (17) on a punch 12 with die edges (20), (21) for shearing the longitudinal edges of the tabs, the leading edge 18 of the punch, which may be rounded, rupturing the sheet metal to form a sharp edge 4 on each tab. The tabs are set at an angle of 2-20 degrees with respect to each other or an angle of 91-100 degrees with respect to the plane of the sheet metal. The leading edge 18 of the punch may be angled to form edges 4 as shown in Fig. 11 and the tabs may be transversely curved. In the hinge shown in Fig. 11 the tabs are inclined relative to the longitudinal direction of hinge plates 2. Such hinges 1 and hinges 7 having plates 2 connected to a central hinge by flanges (6), Fig. 3 (not shown), at right angles to the plates 2 are secured to wood or plastics panels 9, 10 to form a collapsible container 8, by impaling the panels on the tabs.
Patent FI-81910-B (FI)
Title: Maximum thermometer for disposable use and method for its production
Inventor: HOLM KARL
IPC: G01K/
Filed: 1983-02-08
Granted: 1990-08-31
Abstract: A disposable maximum reading thermometer comprises a body (40) in which a capillary passage is defined, a reservoir (41) communicating with the passage and a heat expansible indicator medium (46) contained in the reservoir. The reservoir and the passage are adapted to allow expansion of the medium in the passage when the medium is subjected to heating. At least a part of the passage wall exposable to the indicator medium is adapted to undergo a detectable and irreversible change of its light penetration characteristics when brought into contact with the medium. The capillary passage is defined by a rod (48) arranged in a longitudinally extending bore (42) of the body (40). The surface of the rod is frosted (matt) or opalized, preferably by a mechanical treatment, and adapted to be deopalized when brought into contact with the medium. The medium is preferably a greasy substance having an index of refraction substantially identical to the index of refraction of the material of the body (40) and a melting point range of some degrees centigrade in the relevant temperature range.
Patent FI-70558-B (FI)
Inventor: PETERSSON STIG ARVID
IPC: C01B17/76
Filed: 1983-06-16
Granted: 1986-06-06
Abstract: Method of utilizing process gas containing sulphur dioxide obtained from discontinuous processes, in the manufacture of sulphuric acid in a contact plant. When practicing the method according to the invention, all of the process gas, or a predetermined amount thereof, is withdrawn from the process during process operational periods, in which gas containing sulphur dioxide is generated, and the sulphur dioxide contained by the withdrawn gas is at least partially separated therefrom to form a liquid phase containing the amount of sulphur dioxide separated. The gas partially freed from sulphur dioxide, together with any non-withdrawn process gas, is passed to the contact plant for manufacturing sulphuric acid. Stored absorption liquid is utilized during those periods in which no process gases are produced or passed to the contact plant or in which the process gases contain insufficient sulphur dioxide. Sulphur dioxide is stripped from the liquid phase with the aid of a carrier gas, and the carrier gas, together with the stripped sulphur dioxide, is passed to the contact plant. This enables a required amount of gas and sulphur dioxide to be constantly supplied to the contact plant, even during those periods when the discontinuous process does not produce a sulphur-dioxide-containing gas or produce a gas having an insufficiently high sulphur-dioxide amount.
Patent FI-78103-B (FI)
Inventor: EFFLAND RICHARD C
IPC: C07D498/04
Filed: 1984-11-05
Granted: 1989-02-28
Abstract: This invention relates to novel compounds of the formula I <CHEM> wherein m and n are each independently 0, 1 or 2 and m + n is 1 or 2, X and Y are each independently hydrogen, loweralkyl or halogen and RS is methyl or benzyl, which are useful as intermediates for the preparation of 11-substituted 5H,11H-pyrrolo [2,1-c] [1,4] benzoxazepines of the formula II <CHEM> The compounds of formula II exhibit antipsychotic and analgesic activities and can, therefore, be used as medicaments.
Patent FI-82374-B (FI)
Inventor: KLUEPPEL HANS-JUERGEN
IPC: A61Q11/00
Filed: 1985-10-24
Granted: 1990-11-30
Abstract: Oral and dental preparations containing as an active ingredient an anti-caries effective amount of a C2-4 alkoxylated trihydric to hexahydric C3-12 aliphatic polyol wherein at least one hydroxyl moiety is esterified with phosphoric acid, or a physiologically compatible water soluble salt thereof.
Patent FI-87982-B (FI)
Inventor: DELNON HANSPETER
IPC: A61B6/14
Filed: 1986-01-24
Granted: 1992-12-15
Abstract: The apparatus (10) for orthoradial panoramic tomography comprises a radiation source (111) for motion relative to a point of reference (Pb); a cassette means (112) also for motion relative to the point of reference; a support (11) for holding the radiation source (111) and the cassette (112) relative to the point of reference; a head positioning means (16, 25) including a first or intraoral device (25) and a second or extraoral device (16) for positioning the patient's head relative to the point of reference; a carriage (12) connected with the support (11) and including a grip (121); a substantally vertical column (14) for slidingly holding the carriage (12) in a vertically defined position and having a vertical axis (A<1>) distanced from the point of reference; the apparatus further comprises a foot positioning means (17) having a substantially horizontal reference face (170) for defining a vertical distance from the horizontal reference face to the point of reference (Pb) and a substantially vertical reference face (171/172) for maintaining toe and/or heel portions of the patient's feet in a predetermined position; a distancing means (18) is provided for maintaining the at least one vertical reference face (171/172) at a reproducible horizontal distance from the vertical axis (A min ) of the column (14); and a means (19) is arranged for determining and reproducibly setting a vertical distance between the horizontal reference
Patent FI-84933-B (FI)
Inventor: DE PUTTER WARNER JAN
IPC: F16L55/16
Filed: 1986-08-22
Granted: 1991-10-31
Abstract: A plastic pipe l consisting of an outer corrugated plastic pipe 2 and an inner smooth wall 4 consisting of a wear resistant elastomer, particularly a thermoplastic rubber fixed in the inner bottoms wave valleys 8a to said outer corrugated pipe 2. The inner wall 4 consists of a pipe which has been coextruded with the outer corrugated pipe 2 so that the inner and outer pipe are heat welded to each other l0a.The cavities 9 between the inner pipe l0 and the corrugations 3 may be filled with a foam plastic 7. This plastic pipe l is used for repairing or renewing a sewage pipe l2 by installing such a pipe l from a vertical shaft ll of the sewage system into the sewage pipes l2. The interstices l6 between the outer side of the corrugations 3 and the inner side of the sewage pipe l2 may be filled with a mortar l7.
Patent FI-89681-B (FI)
Inventor: LAURITZEN ANN MARIE
IPC: B01J23/32
Filed: 1987-10-30
Granted: 1993-07-30
Abstract: A composition containing silver, a support, rhenium and at least one further metal, characterized in that the selected amounts of the metals or compounds are such that under conditions of catalytic manufacture of e thylene oxide from ethylene and oxygen the composition comprises a catalytically effective amount of silver, a promoting amount of rhenium or compound thereof and a promoting amount of at least one further metal or compound thereof.