Patent GB-963907-A (GB)
Title: Compositions including a phenolic component and a polyamine component
IPC: A01N33/04
Filed: 1960-11-10
Abstract: A germicidal composition useful for the degerming of skin hair, scalp, oral and other body openings comprises combinations of anionic and cationic substances whereof the anionic component is phenolic and the cationic component is a derivative of an alkylene polyamine.  The cationic component may be (1) N-alkylated or alkenylated alkylene polyamines which possess at least one of said aliphatic hydrocarbon groups having from 6 to 20 carbon atoms joined to one of the amino nitrogen groups and having one to five alkylene groups interconnected by nitrogen atoms and represented structurally as follows: X-NH-R-(NH-R)n-NY1Y2 in which R is an alkylene radical which may be the ethylene radical (-CH2CH2-), the isopropylene radical [-CCH2CH(CH3)-], the trimethylene radical (-CH2CH2CH2-), or a mixture of such radicals and "n" may be zero, in which case the parenthesized group is non-existent or "n" may be a whole number from 1 to 4; and X is an alkyl or alkenyl radical which may have from one to twenty carbon atoms, e.g. in the alkyls in the range from methyl or eicosyl (C20H41-) and Y1 and Y2 are hydrogen atoms or alkyl or alkenyl or carboxyalkyl or carboxy alkenyl groups having from 1 to 20 carbon atoms in the aliphatic hydrocarbon radical or (2) Acylamidoalkylene polyamines wherein the acyl group has from 2 to 20 carbon atoms joined through the carbonyl group to one of the amino nitrogen groups and having one to five alkylene groups interconnected by nitrogen atoms, and may be represented structurally as follows: <FORM:0963907/A5-A6/1> in which the symbols "X", "R," "Y1" and "Y2" and "n" are as already defined.  The anionic components are:  1. Simple phenolics, such as: phenol, cresol, O-phenylphenol and the halogenated phenolics, such as p-chloro-meta-xylenol, dichloro-metaxylenol, o-benzyl p-chlorophenol and p-isoamylphenol. 2. Bis-phenolics, e.g.: 2,21-methylene bis-(3,4,6-trichlorophenol), 2,21-methylene bis-(4,6-dichlorophenol), 2,21-methylene bis-(4-chlorophenol), 2,21-thio bis-(4,6-dichlorophenol).  3. Salicylanilides, e.g. salicylanilide, monohalogenated salicylanilides, polyhalogenated salicylanilides.  Also included among the aforesaid anionics are halogenated carbanilides and thiocarbanilides.  Specified combinations are hexachlorophene and lauryl diethylene triamine, lauroylamido diethylene diamine and 2,21-thio bis-(4,6-dichlorophenol); dimethylamino propyl lauramide and o-benzyl-p-chlorophenol; dimethylamino propyl stearamide and 2,21-methylene bis-(4,6-dichlorophenol); lauryl diethylene triamine and 3,4,41-trichloro-carbanilide; lauryl diethylene triamine and 3,31, 41, 5-tetrachlorosalicylanilide; stearyl triethylene tetramine and 41,5 - dibromsalicylanilide, tetrachlorosalicylanilide and lauryldiethylene triamine; 41,5-dichlorosalicylanilide and lauryldiethylene triamine; laurylamide ethylene diamine and 2,21-methylene bis - (3,4,6 - trichlorophenol); dimethylamino propyl lauramide and 2, 21-thiobis - (41,6 - dichlorophenol); lauryl diethylamine triamine and 4,51 - dibromo - salicylanilide lauryl triethylene tetramine and 3,31,41,5-tetrachlorosalicylanilide and laurylethylene diamine and 3, 4, 41-trichlorocarbanalide.  U.S.A. Specification 2,267,204 and German Specification 1,041,627 are referred to.