Patent SG-11201908181X-A (SG)
Title: Solid forms and combination compositions comprising a beta-lactamase inhibitor and uses thereof
Inventor: BURNS CHRISTOPHER J
IPC: A61P31/04
Filed: 2018-03-05
Abstract: JI l a Jul () INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 13 September 2018 (13.09.2018) W I PO I PC T IiiimmoimiolollmonolomommoolinioniovoimIE (10) International Publication Number WO 2018/165048 Al (51) International Patent Classification: A61K 31/69 (2006.01) A61P 31/04 (2006.01) A61K 31/546 (2006.01) (21) International Application Number: PCT/US2018/020968 (22) International Filing Date: 05 March 2018 (05.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/467,750 06 March 2017 (06.03.2017) US 62/467,752 06 March 2017 (06.03.2017) US 62/564,989 28 September 2017 (28.09.2017) US 62/564,990 28 September 2017 (28.09.2017) US (71) Applicant: VENATORX PHARMACEUTICALS, INC. [US/US]; 30 Spring Mill Drive, Malvern, Pennsylvania 19355 (US). (72) Inventors: BURNS, Christopher J.; 30 Spring Mill Dri- ve, Malvern, Pennsylvania 19355 (US). PEVEAR, Daniel C.; 30 Spring Mill Drive, Malvern, Pennsylvania 19355 (US). XERRI, Luigi; 30 Spring Mill Drive, Malvern, Pennsylvania 19355 (US). HENKEL, Timothy; 30 Spring Mill Drive, Malvern, Pennsylvania 19355 (US). MCGAR- RY, Daniel; 30 Spring Mill Drive, Malvern, Pennsylva- nia 19355 (US). ROSEN, Lawrence; 30 Spring Mill Dri- ve, Malvern, Pennsylvania 19355 (US). BRENNER, Ger- ald; 3007 Oakwood Drive, Plymouth Meeting, Pennsylva- nia 19462 (US). ARLIN, Jean-Baptiste; Meibergdreef 31, 1105 AZ Amsterdam (NL). FERNANDEZ CASARES, Ana; Meibergdreef 31, 1105 AZ Amsterdam (NL). (74) Agent: HARDT, Ingo H.; Wilson Sonsini Goodrich & Rosati, 650 Page Mill Road, Palo Alto, California 94304 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (54) Title: SOLID FORMS AND COMBINATION COMPOSITIONS COMPRISING A BETA-LACTAMASE INHIBITOR AND USES THEREOF FIG. 2 GC 71' O 00 0 (57) : Described herein are crystalline forms of (R)-3-(2-(trans-4-(2-aminoethylamino)cyclohexyl)acetamido)-2-hy- droxy-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid. In some embodiments, the crystalline forms are formulated for O treating a subject in need thereof with a bacterial infection. [Continued on next page] WO 2018/165048 Al MIDEDIMOMOIDEIREEMOMMEMINNIEHIMMIS SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))