Patent CA-3024425-A1 (CA)
Inventor: MAI VAN HUNG
IPC: C07F17/02
Filed: 2018-12-19
Abstract: Acridine....................................................................... ............................................24 4-[CH3C(=O)]C6H4CN............................................................... ............................ 25 4-[HC(=O)] C6H4CN......................................................................... ......................26 4-Et(C=O)NHC6H4CN................................................................ ............................27 4-MeO-C6H4CN......................................................................... .............................28 4-NH2C6H4CN...................................................................... ..................................29 Ethyl methacrylate................................................................... ................................30 Sulfonylbenzonitrile........................................................... .......................................31 VIII-3. X-ray crystal structure of [Cp(IPr)Ru(pyr)2][PF6]..........................................32 Figure 9. The molecular structure of complex [Cp(IPr)Ru(pyr)2][PF6]. The counter-anion, the THF solvate, and hydrogen atoms are omitted for clarity........................32 IX. Reference...................................................................... .....................................32 I. Title Novel ionic half sandwich ruthenium complexes supported by N-heterocyclic carbene and/or phosphines, as efficient transfer hydrogenation catalysts. II. Abstract The ionic half-sandwich complexes of ruthenium (II) with the formula of (I), where Cp* are selected from cyclopentadienyl or pentamethylcyclopentadienyl groups. Ligands L1, L2 and L3 of the complex (1) can be the same or different from each other, the moieties groups of ligands L1, L2 and L3 are N-containing molecules, and/or O-containing molecules, and/or S-containing molecules, and/or P-containing molecules, for examples, N-heterocylic carbene, phosphines, pyridines, nitriles, thiourea, and others. Anion of the compound (I) can be varied from low coordinating to non-coordinating anions, for example, triflate (CF3SO3-) tetrafluoroborate ([BF4]-), hexafluorophosphate ([PF6]-), perchlorate ([ClO4]-), tetrakis-[3,5 -bis(trifluoromethyl)phenyl]borate ion, [B[3,5-(CF3)2C6H3]4]-, tetrakis-(pentafluorophenyl)-borate (B(C6F5)4-) and A1(OC(CF3)3)4-. Furthermore, the preparation and catalytic reactivity of these complexes are described. L1, L2, L3 = N-containing molecules and/or O-containing molecules and/or S-containing molecules and/or P-contaning molecules, for examples, N-heterocylic carbene, phosphines, pyridines, nitriles, thiourea,and others Anion.THETA. = Either low-coordinating or noncoordinating anions such as triflate (CF3SO3-) tetrafluoroborate ([BF4]-), hexafluorophosphate ([PF6]), perchlorate ([ClO4]-), tetrakis[3,5 -bis(trifluoromethyl)phenyl]borate ion, [B[3,5-(CF3)2C6H3]4]-, tetrakis(pentafluorophenyl)borate (B(C6F6)4-) and Al(OC(CF3)3)4-Cp*=Cyclopentadinyl or pentamethylcyclopentadienyl Figure 1. Half sandwich ruthenium complexes III. Field of the invention The present patent relates to new ionic half sandwich ruthenium complexes, which are useful as efficient transfer hydrogenation catalysts. IV. A broad description of the invention One of the most important processes to synthesis N-containing compounds is the reduction of nitriles. The conventional method to reduce nitrile is the stoichiometric usage of metal hydrides LiA1H4 or NaBH4, hydrosilanes, or Hantzsch ester.1-3 These methods normally end up with many economic and environmental issues such as poor atom efficiency, low selectivity, expensive and hazardous reagents, less tolerated to functional groups, and wasteful by-products. In this invention, we have now surprisingly discovered the new half sandwich ruthenium complexes,4-11 which shows the significant performance in the transfer-hydrogenation of nitriles under mild conditions. In addition, these new compounds also display excellent bio-reactivities. The scope