baber/WOPTO huggingface dataset:
Patent WO-9309233-A3 (WO)
Title: Domaine des inhibiteurs de proteine de precurseur amyloïde et traitement de divers etats pathologiques
Inventor: WAGNER STEVEN L
IPC: A61K38/00
Filed: 1992-10-30
Abstract: L'invention concerne la production d'un peptide inhibiteur de protéase du type Kunitz (KPI), et son utilisation pour la régulation de l'activité des protéases associées à l'amylase. Cette invention concerne en outre des modèles in vivo et in vitro de l'amylase impliquant le peptide KPI. Le peptide KPI peut également être utilisé pour traiter les troubles de coagulation par régulation des protéases dans le chemin de coagulation. KPI est également utilisé pour inhiber ou atténuer les dommages associés au protéase suite à une blessure, en particulier les blessures à la tête. Des séquences d'acide nucléique codant l'inhibiteur de protéase et des systèmes d'expression pour l'expression de haut niveau de l'inhibiteur actif sont également décrits.
Patent WO-9411509-A3 (WO)
Title: Peptides et peptides anti-sens a large specificite neoplasique
Inventor: DO COUTO FERNANDO J R
IPC: C07K19/00
Filed: 1993-11-16
Abstract: Un analogue peptidique comprend les régions variables des chaînes légères ou lourdes d'un anticorps appartenant à une première espèce se liant sélectivement à un antigène tumoral, tel qu'un antigène de carcinone, 1 à 46 aminoacides des régions de structure par chaîne étant substitués par des aminoacides tels que ceux présents dans des positions équivalentes dans des anticorps d'une espèce autre que la première, ou des fragments comprenant 1 à 3 régions de détermination de complémentarité (CDR) à région variable par chaîne et éventuellement leurs régions d'encadrement contenant au moins 1 à 10 aminoacides, seuls ou avec un fragment N-terminal d'au moins 1 à 10 aminoacides, des combinaissons ou des mélanges de ces éléments. Le polypeptide peut également comprendre un agent effecteur et/ou être glycoxylé, et est présenté sous forme d'une composition et d'un excipient. Les analogues peptidiques sont utilisés dans des kits diagnostiques pour des néoplasmes tels que des carcinomes et dans des procédés d'imagerie in vivo et de traitement d'un néoplasme primaire ou à métastase tel qu'un carcinome et de diagnostic in vitro d'un néoplasme ainsi que de la purge ex vivo d'un fluide biologique de cellules néoplasiques. Des ARN et des ADN codent le peptide analogue, et un vecteur hybride portant les nucléotides et des cellules transféctées expriment les peptides, tandis qu'un procédé permet de produire l'analogue peptidique. Un polypeptide anti-idiotypique comprend des anticorps polyclonaux cultivés et dirigés contre un anticorps antinéoplasique ou l'analogue peptidique de cette invention, ses anticorps monoclonaux, Fab, Fab', (Fab')2, CDR, une région variable, des analogues ou des anticorps, des combinaisons de l'analogue avec un oligopeptide comprenant un trimère de TRP, des séquences répétées en tandem ou une combinaison ou des mélanges de ces éléments. L'invention se rapporte également à un polypeptide hybride anti-idiotypique comprenant un agent effecteur et le polypeptide anti-idiotypique, un vaccin antinéoplasique, un kit de vaccination antinéoplasique, un procédé de vaccination contre les néoplasmes tels que les carcinomes, ainsi qu'un procédé permettant de diminuer la concentration sérique d'un anticorps circulant ou d'un polypeptide.
Patent WO-9635923-A3 (WO)
Title: Composants de transducteurs acoustiques
Inventor: SPRECHER ARNOLD FRED JR
IPC: G10K11/24
Filed: 1996-05-10
Abstract: On décrit un dispositif de suspension (2) de guide d'ondes et une construction modulaire de guide d'ondes acoustiques (4), comprenant un élément amortisseur (6) s'utilisant avec un guide d'ondes (4), prévu pour une impulsion de courant, et qui produit une onde de contrainte en torsion ou longitudinale. L'élément amortisseur (6) empêche la réflexion de l'onde de contrainte acoustique et comprend un manchon (27) entourant le guide d'ondes et un mécanisme (29) permettant d'appliquer une pression sur ce manchon (27) qui la répercute sur le guide d'ondes (4), ce qui amortit progressivement l'énergie de l'onde de contrainte acoustique tout au long du guide d'ondes (4) entouré par le manchon (27) de l'élément amortisseur et empêche les réflexions de l'onde de contrainte acoustique. De plus, le placement du conducteur de retour (1) est déterminé par mesure de la réponse du système afin de donner une oscillation minimale du signal reçu d'un bobinage capteur (13). En outre, le mécanisme de suspension (2) entoure le guide d'ondes, ce qui évite tout bruit externe. On décrit un support (10) qui facilite le montage de l'ensemble guide d'ondes, ainsi qu'un circuit tampon local, utilisé avec un transducteur magnétostrictif (4) qui comprend un bobinage capteur (13). Ce circuit tampon local comporte deux diodes (22, 23) montées en parallèle avec le bobinage capteur (13) pour écrêter ou court-circuiter l'énergie produite dans ce bobinage (13) par une impulsion d'interrogation, et il comporte aussi un émetteur amplificateur commun (24) destiné à abaisser l'impédance électrique du bobinage capteur (13) et monté également en parallèle avec ce bobinage (13).
Patent WO-9709730-A3 (WO)
Title: Emetteur lateral sur pilier et limiteur de courant non lineaire pour afficheurs a emission de champs et autres applications a sources d'electrons
Inventor: JONES GARY W
IPC: H01J1/304
Filed: 1996-08-19
Abstract: La présente invention concerne un dispositif micro-électronique (50) à émission de champ comprenant un substrat (78), un pilier électroconducteur (64) reposant sur le substrat et une électrode d'émission de champ reposant sur le pilier, l'électrode d'émission latérale étant pourvue d'une couche de couverture (66) d'émetteur caractérisée par son chant (68). L'invention concerne également un limiteur de courant pour un dispositif micro-électronique constitué d'un matériau semi-isolant appartenant au groupe des SiO, SiO + Cr (pour 0 à 50 % de la masse), SiO2 + Cr (pour 0 à 50 % de la masse), SiO + Nb, Al2O3 et SixOyNz placé en sandwich entre un injecteur d'électrons et un injecteur de trous. Selon une autre réalisation, l'invention concerne un dispositif micro-électronique à émission de champ comprenant un substrat (240), un conducteur émetteur (242) reposant sur un tel substrat, et un empilement (244) limiteur de courant réalisé sur ce substrat. Un tel empilement est caractérisé par un sommet (246) et au moins un chant (248, 250), une barrette résistive (266) disposée sur le sommet de l'empilement et à cheval sur le chant, en contact électrique avec le conducteur émetteur, et enfin une électrode émetteur reposant sur l'empilement limiteur de courant à cheval sur la barrette résistive.
Patent WO-9744983-A3 (WO)
Inventor: TIEDEMANN EDWARD G JR
IPC: H04B7/02
Filed: 1997-05-22
Abstract: In a communications network, a network user communicates using a remote unit with another user via at least one base station. The communications network has a first base station having a first coverage area and a second base station having a second coverage area. In the situation where communication is not established between the second base station and the remote unit, in order to provide communication between the remote unit and the first base station when the remote unit is in the first coverage and simultaneously in the second coverage area, the first base station produces a first active communication signal at intended for the remote unit. The first base station transmits the first active communication signal from a first antenna. The base station delays the first active communication signal to produce a first delayed active communication signal and transmits it from a second antenna wherein the second antenna is oriented with respect to the first antenna such that the first active communication signal and the first delayed active communication signal fade independently as perceived by the remote unit. The first base station may measures a round trip delay of the first active communication signal in order to identify that the remote unit is located within the second coverage area.
Patent WO-9840058-A3 (WO)
Inventor: ZHANG RUIWEN
IPC: A61K9/00
Filed: 1998-03-12
Abstract: Disclosed is a method of down-regulating the expression of a gene in an animal, wherein an oligonucleotide complementary to the gene is colorectally administered to an animal. Also disclosed is a method for introducing an intact oligonucleotide into a mammal by colorectal administration, whereby the oligonucleotide is present in intact form in the systemic plasma of the mammal at least four hours following administration.
Patent WO-9850680-A3 (WO)
Inventor: TUBEL PAULO
IPC: E21B47/10
Filed: 1998-05-01
Abstract: The present invention provides systems utilizing fiber optics for monitoring downhole parameters and the operation and conditions of downhole tools. In one system fiber optics sensors are placed in the wellbore to make distributed measurements for determining the fluid parameters including temperature, pressure, fluid flow, fluid constituents and chemical properties. Optical spectrometric sensors are employed for monitoring chemical properties in the wellbore and at the surface for chemical injection systems. Fiber optic sensors are utilized to determine formation properties including resistivity and acoustic properties compensated for temperature effects. Fiber optic sensors are used to monitor the operation and condition of downhole devices including electrical submersible pumps and flow control devices. In one embodiment, a common fluid line is used to monitor downhole parameters and to operate hydraulically-operated devices. Fiber optic sensors are also deployed to monitor the physical condition of power lines supplying high electric power to downhole equipment. A light cell disposed downhole is used to generate electric power in the wellbore, which is used to charge batteries.
Patent WO-9851812-A3 (WO)
Inventor: WILLIAMS SIMON F
IPC: C12N5/00
Filed: 1998-05-12
Abstract: Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided. PHAs which have been chemically modified to enhance physical and/or chemical properties, for targeting or to modify biodegradability or clearance by the reticuloendothelial system (RES), are described. Methods for depyrogenating PHA polymers prepared by bacterial fermentation processes are also provided, wherein pyrogens are removed from the polymers without adversely impacting the polymers' inherent chemical structures and physical properties. PHAs with advantageous processing characteristics, including low melting points and/or solubility in non-toxic solvents, are also described. The PHAs are suitable for use in in vivo applications such as in tissue coatings, stents, sutures, tubing, bone, other prostheses, bone or tissue cements, tissue regeneration devices, wound dressings, drug delivery, and for diagnostic and prophylactic uses.
Patent WO-9934004-A3 (WO)
Title: Metastatic breast and colon cancer regulated genes
Inventor: XIN HONG
IPC: C12Q1/6886
Filed: 1998-12-24
Abstract: Gene sequences as shown in SEQ ID NO:1-18 have been discovered and isolated, and found to be significantly associated with metastatic spread of breast and colon cancer cells to other organs. Methods are provided for determining the risk of metastasis of a breast or colon tumor, which involve determining whether a tissue sample from a tumor expresses a polypeptide encoded by a gene as shown in SEQ ID NOS:1-18, or a substantial portion thereof. One of the gene sequences encodes a novel aspartyl protease termed CSP56, which can be used to provide reagents and methods for determining which tumors are likely to metastasize and for suppressing metastases of these tumors. Clinicians can use this information to predict which tumors will metastasize to other organs and to provide relevant therapies to appropriate patients.
Patent WO-0023599-A3 (WO)
Title: Human proteins involved in endoplasmic reticulum protein degradation
Inventor: CHAU VINCENT
IPC: C12Q1/68
Filed: 1999-10-21
Abstract: The invention relates to degradation of proteins via the ubiquitin-proteasome pathway. More particularly, the invention relates to the degradation of proteins in the ER, including cystic fibrosis transmembrane conductance regulator (CFTR) via the ubiquitin-proteasome pathway. The invention provides methods and compositions for inhibiting such degradation and for promoting the maturation of ΔF508 into a functional CFTR and for understanding the role of loss of CFTR function in CF. The invention resides in the discovery of human proteins responsible for the ubiquitination of ΔF508, CFTR, and α1-AT.
Patent WO-0038740-A3 (WO)
Title: Procede et dispositif servant a steriliser de petits objets
Inventor: ECKHARDT RICHARD A
IPC: A61J17/00
Filed: 1999-12-21
Abstract: Procédés et dispositifs servant à stériliser de petits objets. On introduit un petit objet dans une chambre située dans le stérilisateur. Une partie de ce petit objet épouse un mécanisme de verrouillage, ce qui met ce dernier hors service. Après la mise hors service du mécanisme de verrouillage, le stérilisateur produit au moins un éclair de lumière ultraviolette extrêmement intense émise par une source de lumière ultraviolette. Cet éclair de lumière ultraviolette détruit les micro-organismes de la surface du petit objet. La chambre du stérilisateur peut être doublée par un revêtement réfléchissant afin de disperser la lumière ultraviolette autour de la chambre, de sorte que la majeure partie, sinon la totalité, du petit objet placé à l'intérieur du stérilisateur est exposée à la lumière ultraviolette.
Patent CU-22911-A3 (CU)
Title: Sistema de compra impulsiva para televisión de pago
Inventor: STRANSKY PHILIPPE
IPC: H04N21/4623
Filed: 2002-01-09
Abstract: En un sistema de televisión de pago, la elección y la validación de una compra impulsiva son efectuadas por el usuario tras la presentación mediante una pantalla de un mosaico de programas. La selección por este usuario de un programa en particular de su elección en el mosaico es ulteriormente validada en el sistema por un mensaje de administración de cualificación, este mensaje siendo específico de una compra impulsiva. Con el fin de autorizar la visualización inmediata de la emisión seleccionada, el mensaje de administración de cualificación específica de una compra impulsiva está contenido en los datos asociados a la presentación del mosaico.
Patent CZ-20001942-A3 (CZ)
Title: Rubber powders containing high amounts of filling agents, process of their preparation and their use
Inventor: GOERL UDO DR
IPC: C08K9/06
Filed: 2000-05-25
Abstract: Rubber powder with a high filler content contains filler, preferably precipitated silicic acid, whose surface is modified wi an organosilicate, and/or carbon black. Rubber powder comprises oxidic or preferably silicated filler, preferably precipitated silicic acid used at 250-5000 phr if synthetic or 350-500 if natural, whose surface is modified with an organosilicate of formula (I), (II) or (III) and/or 250-5000 carbon black, the total amount of filler being not above 5000 phr: ((R<1>n(RO)3-nSi(Alk)m(Ar)p)q)(B) (I) R<1>n(RO)3-nSi(Alkyl) (II) R<1>n(RO)3-nSi(Alkenyl) (II) B = SCN, SH, Cl, NH2 (q = 1) or Sx (q = 2); R and R<1> = 1-4C alkyl or phenyl; n = 0, 1 or 2; Alk = 1-6C alkyl; m = 0 or 1; Ar = 6-12C arylene; p = 0 or 1 provided that m, n and p are not all 0; x = 2-8; Alkyl = 1-20 (2-8) C hydrocarbon; and Alkenyl = 2-2 (2-8) C hydrocarbon. Independent claims are included for: (a) the preparation of the above finely divided rubber powder by precipitation from aqueous mixtures containing filler in suspension and a rubber aqueous emulsion or solution by the addition of metal salts of group IIa, IIb, IIIa or VIII comprising mixing a polymer latex, emulsion of solution with a suspension prepared by forming a filler suspension of water, silicate compou and/or carbon black of suspension density 0.5-10 (1-7) %, optionally deagglomerating and optionally adding 0.5-10 pts. polyalcoh or polyamines, heating at 25-95 degrees C, adding an organosilicate as above, optionally in the presence of a surface active material, and stirring at 10-60 degrees C, washing to remove acid, drying and grinding; and (b) the preparation of vulcanized rubber mixture by adding the above rubber powder to a rubber mixture as a filler along wi other optional additives.
Patent CZ-20002471-A3 (CZ)
Inventor: WESJOHANN ERICH
IPC: A23L31/00
Filed: 2000-06-29
Abstract: Způsob zpracování hub spočívá v tom, že se houby
bezprostředně po manuálním sklizení ukládají odděleně na
ukládacím zařízení, s výhodou rovinném, a chladí se. Chlazení
se provádí výhodně proudem vzduchu o vlhkosti 95 až 99 % a
teplotě 0 až 2 °C. Po ochlazení se houby výhodně přivádějí k
řezacímu zařízení, v němž se pomocí rotujících nožů
odřezávají nohy hub.
Patent CZ-20011285-A3 (CZ)
Title: Engine block made of light metal and process for producing a cylinder liner and the engine block provided with such liner
Inventor: HORRMANN DIETMAR
IPC: F02F7/00
Filed: 2000-08-05
Abstract: A light metal cylinder crankcase for combustion engines has cylinder bushings with a running layer that forms the running surface and a rough, external bonding layer for bonding the cylinder bushings to the cylinder crankcase while pouring the cylinder crankcase. At least 60% of the bonding layer relative to the jacket surface of the bonding layer is connected with the casting material of the cylinder crankcase in a material tight manner.
Patent CZ-20011524-A3 (CZ)
Title: Use of thiazolidinediones derivatives for preventing uterine contractions in premature labor or lactation
Inventor: COPLAND JOHN A III
IPC: A61P15/06
Filed: 1999-10-29
Abstract: The present invention provides methods of preventing or reducing oxytocin-mediated action by using a thiazolidinedione, such as troglitazone, or thiazolidinedione-like compounds. These methods describe the employment of these compounds alone or in combination with at least one other agent, such as a tocolytic agent. This offers a novel therapeutic regimen for the treatment of oxytocin-mediated actions, for example induction of uterine contractions, prostaglandin release, and milk letdown. Accordingly, conditions such as preterm labor and labor prior to Caesarean delivery can be treated by these methods.
Patent CZ-20012340-A3 (CZ)
Title: Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications
Inventor: KELLER BRADLEY T
IPC: A61K31/4995
Filed: 1999-12-17
Abstract: The present invention provides combinations of cardiovascular therapeutic compounds for the prophylaxis or treatment of cardiovascular disease including hypercholesterolemia, atherosclerosis, or hyperlipidemia. Combinations disclosed include an ileal bile acid transport inhibitor combined with a cholesteryl ester transfer protein (CETP) inhibitor.
Patent CZ-20012418-A3 (CZ)
Title: Process for producing entrance body for car locks
Inventor: BLASTIK TOMAS ING
IPC: B60R25/00
Filed: 2001-06-29
Abstract: The invented entrance body for car locks is U-shaped and formed by an attachment plate (11), a frame (12) and a connecting segment (13). Coaxial holes (113, 121) intended for a pin are performed in both said attachment plate (11), and said frame (12). The entrance body is manufactured by gradual cold forming in working stations (I to XIV) following each other of a transfer production line wherein all the forming operations are carried out simultaneously for a pair of entrance bodies (1). In the first working station (I) holes (113) for the pin head and service holes (3) are cut out in a metal material band (2), in the second working station (II) a locating shape (5) comprising the pair of entrance bodies (1) is trimmed and marking (4) of the entrance body (1) is carried out. The third working station (III) serves for angular displacement of the locating shape (5) into a working position. In the fourth working station (IV) depressions (14) and dimples (114) around the hole (113) for the pinhead are formed. In the fifth working station (V), there is formed a circumferential edge (115) in the region of the attachment plate (11), in the sixth working station (VI) holes (111) are cut out in the attachment plate (11) intended for fixing bolts and a neck (122) is drawn from an arm (12) into the solid material without cut-out. In the seventh working station (VII), a hole (121) in the neck (122) is cut out for the pin and a final cutout of the hole (113) in the dimple (114) for the pinhead. In the eighth and ninth working stations (VIII, IX) an external shape (6) of the entrance body (1) is trimmed in parts. In the tenth working station (X), a final trimming of the external shape (6) of the entrance body (1) is carried out by precise cut and a portion of a connecting bridge (7) between the pair of the entrance bodies (1) is cut out. In the eleventh working station (XI) the circumferential edge is chamfered by compression and the neck (122) is calibrated. In the twelfth working station (XII) the arm (12) is partially bent relative to the connecting element (13). In the thirteenth working station (XIII) this bend is finished and in the fourteenth working station (XIV) the connecting element (13) is bent relative to the attachment plate (11) to a final U-shape, and the pair of entrance bodies (1) is cut apart. This is the final cold forming operation. After cutting of a thread (123) in the hole (121) of the neck (122) and milling tapered dimples (112) around the holes (111) in the attachment plate (11) for the fixing bolts, the entrance body (1) is ready for mounting the pin.
Patent CZ-20013318-A3 (CZ)
Title: Novel LH-RH-antagonists exhibiting enhanced solubility properties
Inventor: BERND MICHAEL
IPC: C07K1/08
Filed: 2000-03-11
Abstract: The invention relates to peptides which contain N-methylated amino acid building blocks and are provided with improved water solubility. Medicaments containing the inventive peptides can be used for the treatment of hormone-dependent tumours and hormone-influenced, non-malignant diseases.
Patent CZ-20013545-A3 (CZ)
Title: Metallic seamless tube and process for producing thereof
Inventor: NIIMI NORIKAZU
IPC: B22F3/11
Filed: 2001-10-02
Abstract: A metal-made seamless pipe contains, as a main component, at least one kind of metal selected from the group consisting of metals each having a melting point of 1,600 DEG C or more. The metal-made seamless pipe has a porosity of 0.3 to 25% when the porosity is defined as a proportion of the open pores not perforating in the thickness direction of the pipe, present at the outer surface of the pipe, to the total area (100%) of the outer surface of the pipe; and a process for producing such a metal-made seamless pipe. The metal-made seamless pipe is low in processability but can be produced in a small thickness and a small inner diameter, is superior in mechanical strengths and gastightness, and can be suitably used as a sealing member of a translucent vessel of a high-pressure discharge lamp.
Patent CZ-20013777-A3 (CZ)
Title: Method for continuously casting between two rolls ferritic stainless steel strips free of micro-cracks
Inventor: MAZURIER FREDERIC
IPC: C22C38/26
Filed: 2000-03-29
Abstract: The invention concerns a method for continuously casting a ferritic stainless steep strip with thickness not more than 10 mm directly from liquid metal between two cooled rolls with horizontal axes and driven in rotation, characterized in that: the liquid metal composition in weight percentages is as follows: % C+% N<=0.12; % Mn<=1; % P<=0.4; % Si<=1; % Mo<=2.5; % Cr between 11 and 19; A1<=1%; % Ti+%Nb+% Zr<=1; the rest being iron and the impurities resulting from preparation; the Upsilp index of the liquid metal ranges between 35% and 60%, Upsilp being defined by the formula: gammap=420% C+470% N+23% Ni+9% Cu+7% Mn 11.5% Cr 11.5% Si 12% Mo 23% V 47% Nb 49% Ti 52% A1+189: the surface roughness of said rolls being more than 5 mum; in the proximity of the meniscus metal liquid present between the rolls an inerting gas is used consisting of at least 60% by volume of a gas soluble in steel.