Patent SG-11201909406V-A (SG)
Title: Treatment of adipocytes
Inventor: REAUME ANDREW G
IPC: A61K31/495
Filed: 2018-04-09
Abstract: Changein FPG from D (Placebo corrected; USA only) E a) 0) EL -60 t -40 0 0 0 U- 7:3 a) ** (p=0.035) (p=0.067) *** (p=0.003) (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 18 October 2018 (18.10.2018) W I PO I PC T Iiiimmomiolollmonolomomnolomoiliflovois (10) International Publication Number WO 2018/191166 Al (51) International Patent Classification: A61K 31/495 (2006.01) C07D 239/08 (2006.01) A61K 31/505 (2006.01) C07D 239/10 (2006.01) A61K 31/513 (2006.01) C07D 239/22 (2006.01) (21) International Application Number: PCT/US2018/026707 (22) International Filing Date: 09 April 2018 (09.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/483,584 10 April 2017 (10.04.2017) US (71) Applicants: MELIOR PHARMACEUTICALS I, INC. [US/US]; 860 Springdale Drive, Suite 500, Exton, Penn- sylvania 19341 (US). BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICUL- TURAL AND MECHANICAL COLLEGE [US/US]; 3810 W. Lakeshore Drive, Baton Rouge, Louisiana 70808 (US). (72) Inventors: REAUME, Andrew G.; 860 Springdale Dri- ve, Suite 500, Exton, Pennsylvania 19341 (US). CONG, Weina; 860 Springdale Drive, Suite 500, Exton, Pennsyl- vania 19341 (US). GREENWAY, Frank; Pennington Bio- medical Research Center, 6400 Perkins Road, B1035, Ba- ton Rouge, Louisiana 70808 (US). COULTER, Ann; Pen- nington Biomedical Research Center, 6400 Perkins Road, B1035, Baton Rouge, Louisiana 70808 (US). (74) Agent: LEGAARD, Paul K.; Stradley Ronon Stevens & Young, LLP, Malvern, Pennsylvania 19355-1481 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, = (54) Title: TREATMENT OF ADIPOCYTES 0 10 20 30 40 Days on Treatment Figure 1 (57) : The present disclosure provides compositions comprising a lyn kinase activator and TRPM8 agonist, and to methods of: reducing blood glucose levels, weight gain, or fat depot levels; treating metabolic syndrome, Syndrome X, obesity, prediabetes, type II diabetes, type I diabetes; treating hypercholesterolemia, hypertension, coronary heart disease, diabetic neuropathy, lipodystrophy, diabetic retinopathy, erectile dysfunction, kidney disease, dyslipidemia, dyslipoproteinemia, a peroxisome proliferator activated recep- tor-associated disorder, septicemia, a thrombotic disorder, or pancreatitis; inducing the beiging of adipocytes; and preventing pancreatic beta cell degeneration. [Continued on next page] WO 2018/191166 Al MIDEDIMOMOIDEIREEMOMOHHOHOHEROMMIS KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))