Patent SG-11201809702S-A (SG)
Title: Benzenesulfonamide compounds and their use as therapeutic agents
Inventor: ANDREZ JEAN-CHRISTOPHE
IPC: C07D451/02
Filed: 2017-05-19
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111011111111101 1111111101011111011010111010111111111111011111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/201468 Al 23 November 2017 (23.11.2017) WIPO I PCT (51) International Patent Classification: MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, CO7D 401/12 (2006.01) A61K 31/4427(2006.01) PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, CO7D 417/12 (2006.01) A61P 25/08 (2006.01) SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, C07D 451/02 (2006.01) TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (21) International Application Number: (84) Designated States (unless otherwise indicated, for every PCT/US2017/033634 kind of regional protection available): ARIPO (BW, GH, (22) International Filing Date: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 19 May 2017 (19.05.2017) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (25) Filing Language: English EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (26) Publication Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (30) Priority Data: KM, ML, MR, NE, SN, TD, TG). 62/339,773 20 May 2016 (20.05.2016) US 62/432,152 09 December 2016 (09.12.2016) US Published: — (71) Applicant: XENON PHARMACEUTICALS INC. with international search report (Art. 21(3)) — with amended claims (Art. 19(1)) [CA/CA]; 200 - 3650 Gilmore Way, Burnaby, British Co- lumbia V5G 4W8 (CA). (72) Inventors: ANDREZ, Jean-Christophe; 200 - 3650 _ Gilmore Way, Burnaby, British Columbia V5G 4W8 (CA). BURFORD, Kristen, Nicole; 200 - 3650 Gilmore Way, = Burnaby, British Columbia V5G 4W8 (CA). CHOWD- _ HURY, Sultan; 200 - 3650 Gilmore Way, Burnaby, British = _ Columbia V5G 4W8 (CA). COHEN, Charles, Jay; 200 = - 3650 Gilmore Way, Burnaby, British Columbia V5G 4W8 (CA). DEHNHARDT, Christoph, Martin; 200 - = =_ 3650 Gilmore Way, Burnaby, British Columbia V5G 4W8 (CA). DEVITA, Robert, Joseph; 200 - 3650 Gilmore Way, Burnaby, British Columbia V5G 4W8 (CA). EMPFIELD, James, Roy; 200 - 3650 Gilmore Way, Burnaby, British = — = Columbia V5G 4W8 (CA). FOCKEN, Thilo; 200 - 3650 = Gilmore Way, Burnaby, British Columbia V5G 4W8 (CA). GRIMWOOD, Michael, Edward; 200 - 3650 Gilmore = = Way, Burnaby, British Columbia V5G 4W8 (CA). HASAN, Syed, Abid; 200 - 3650 Gilmore Way, Burnaby, British Co- lumbia V5G 4W8 (CA). JOHNSON, James, Philip, Jr.; = _ 200 - 3650 Gilmore Way, Burnaby, British Columbia V5G = 4W8 (CA). ZENOVA, Alla, Yurevna; 200 - 3650 Gilmore = Way, Burnaby, British Columbia V5G 4W8 (CA). = Agent: ROTH, Carol, J. et al.; Seed Intellectual Proper- (74) = _ — ty Law Group LLP, Suite 5400, 701 Fifth Avenue, Seattle, = Washington 98104-7064 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (81) — Il GC 71' Il KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, 0 ei N (54) Title: BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS Il 0 (57) : This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or \" mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated 0 with voltage-gated sodium channels, such as epilepsy.