baber/WOPTO huggingface dataset:
Patent WO-2018200254-A3 (WO)
Title: Console de commande et accessoires pour l'ablation de nerfs par radiofréquence et leurs procédés de fonctionnement
Inventor: SPRINKLE THOMAS
IPC: A61B18/12
Filed: 2018-04-17
Abstract: L'invention concerne des systèmes et des procédés électrochirurgicaux pour l'ablation de nerfs par radiofréquence, une console de commande étant utilisée avec un accessoire de câble passif ou actif pour la connexion à différentes fixations d'électrode, telles que des types de mise à la terre monopolaire et bipolaire. La console de commande comporte une pluralité d'amplificateurs RF qui sont associés à une pluralité de canaux de la console de commande et qui sont mis sous tension en fonction de signaux de commande appliqués non simultanément par un dispositif de commande de la console de commande. La console de commande effectue le stockage et le traitement des données d'identification et des données d'utilisation concernant des accessoires de câble et des fixations d'électrode qui sont connectés ou ont été connectés à la console de commande au fil du temps. La console de commande affiche une représentation de ces données traitées sur une interface utilisateur graphique. La console de commande fournit en outre des composants et des techniques pour la mise en oeuvre de stimulation et de vérification/étalonnage d'impédance pour des situations où les signaux de stimulation ou les signaux de mesure d'impédance sont fournis par la console de commande.
Patent WO-2018217536-A3 (WO)
Title: Magnetic actuator for switching roller finger followers
Inventor: STRETCH DALE ARDEN
IPC: F01L1/18
Filed: 2018-05-17
Abstract: A valvetrain suitable for an internal combustion engine that includes a combustion chamber, a moveable valve having a seat formed within the combustion chamber, and a camshaft includes a latch assembly and a rocker arm assembly. The rocker arm assembly include a rocker arm and a cam follower configured to engage a cam on the camshaft as the camshaft rotates. The latch assembly includes a latch pin mounted on the rocker arm and an actuator mounted on a component distinct from the rocker arm. The actuator includes one or more permanent magnets. The actuator is operable to move the one or more permanent magnets to induce the latch pin to translate from a first position to a second position through magnetic forces provided by the one or more permanent magnets.
Patent WO-2019006005-A3 (WO)
Title: Methods and compositions for treating melanoma
Inventor: GRAEBER THOMAS G
IPC: C12Q1/68
Filed: 2018-06-27
Abstract: The current methods and compositions provide for a novel therapeutic method for treating patients diagnosed with melanoma, especially those that have become resistant to certain other therapies. Accordingly, certain aspects of the disclosure relate to a method for treating melanoma in a subject, the method comprising administering a composition comprising a ferroptosis-inducing agent or other dedifferentiated melanoma-targeting agent to the subject.
Patent WO-2019023383-A3 (WO)
Title: Integral display and display of content
Inventor: HULFORD TIMOTHY B
IPC: A61B17/00
Filed: 2018-07-25
Abstract: An example medical device may include a structural component, and a display integrated into the structural component, the display having an on state in which the display is visible and an off state in which the display is not visually detectable.
Patent WO-2019126833-A3 (WO)
Inventor: HANNA IBRAHIM
IPC: F02F3/14
Filed: 2019-01-17
Abstract: Implementations are disclosed herein that relate to a cylinder occupying structure. An example provides a cylinder system comprising a mechanical cylinder including an internal space in which a fluid is introduced, and a piston configured for reciprocating motion in the internal space, and a cylinder occupying structure including an insertion rod acting as a second piston, wherein the insertion rod is variably inserted into, and retracted from, the internal space of the cylinder in correspondence with the reciprocating motion of the piston and where parts of the insertion rod and the piston may surround the combustion space.
Patent WO-2020028603-A3 (WO)
Title: Player induced counter-balancing of loads on a character in a virtual environment
Inventor: KOJIMA HIDEO
IPC: A63F13/795
Filed: 2019-07-31
Abstract: A method for controlling a character in a virtual environment of an interactive gaming application. The method including receiving characteristics of a virtual environment. The method including receiving a weight distribution profile for virtual objects carried by the character, the weight distribution profile causing an offset in a center of gravity of the character. The method including receiving input to move the character about the virtual environment, the input including a first component for moving the character along a path in the virtual environment, and a second component for providing a counter- force to reduce the offset to the center of gravity. The second component is applied when the character graphically appears to be out-of-balance while moving along the path in the virtual environment responsive to the first component.
Patent WO-2020106357-A3 (WO)
Title: Mithramycin derivatives having increased selectivity and anti-cancer activity
Inventor: ROHR JURGEN
IPC: C07H15/24
Filed: 2019-09-20
Abstract: Mithramycin (MTM) short side chain ketone (SK) derivatives and MTM short side chain diketone (SDK) derivatives are provided. The MTM SK and MTM SDK derivatives are useful for treatment of cancer or neuro-diseases associated with an aberrant erythroblast transformation-specific transcription factor. Unique MTM SK and MTM SDK derivatives have increased selectively toward ETS transcription factor.
Patent WO-2020072460-A3 (WO)
Inventor: DIOLAITI NICOLA
IPC: A61B1/00
Filed: 2019-10-01
Abstract: Systems and methods for controlling movement of a steerable device are provided. In some embodiments, a system may include a control device, a manipulator system, and/or a control system communicatively coupled to the manipulator system and the control device. The control system may track a virtual user-instructed position based on a first user input, determine a device position of a portion of the steerable device, and determine a position discrepancy in a first direction between the determined device position and the virtual user-instructed position. The control system may also receive a second user input commanding motion of the steerable device in a second direction. At least a portion of the second direction may be opposite the first direction. The control system may also reduce the position discrepancy based on an aspect of the second user input and a catch-up profile.
Patent WO-2020159620-A3 (WO)
Title: Bioreachable chiral dopants for liquid crystal applications
Inventor: SAFIR ADAM
IPC: C09K19/02
Filed: 2019-12-06
Abstract: The disclosure discusses chiral dopants for liquid-crystalline materials. Chiral dopants can be bioreachable compounds, i.e., compounds produced from microbes through fermentation. Chiral dopants can also include bioreachable materials that are further modified by chemical synthetic steps. Chiral dopants as discussed herein can include biomolecules such as glycyrrhetinic acid (1), S-narigenin (2), shikimic acid (3), alpha-phellandrene (4), betulin (5), malic acid (6), valencene (7), or nootkatone (8), and any stereoisomers or chemically modified derivatives thereof. The disclosure further shows optical properties of such compounds in a liquid-crystalline material.
Patent WO-2020139830-A3 (WO)
Inventor: HOROWITZ JULIE
IPC: A61P11/00
Filed: 2019-12-23
Abstract: La présente invention concerne des procédés de traitement de patients ayant un trouble respiratoire, des procédés d'identification de sujets ayant un risque accru de développer un trouble respiratoire, et des procédés de détection de molécules d'acide nucléique variant d'Arachidonate 15-lipoxygénase (ALOX15) humaine et de polypeptides variants.
Patent WO-2021087368-A3 (WO)
Title: Anti-cd45 antibodies and conjugates thereof
Inventor: BOITANO ANTHONY
IPC: A61K39/395
Filed: 2020-10-30
Abstract: Disclosed are anti-CD45 antibodies, antigen binding fragments thereof, and antibody drug conjugates (ADCs) that specifically bind to human CD45. Such antibodies and ADCs are useful in therapeutic methods, including methods of depleting CD45+ cells from a patient. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD45+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy, and to improve the engraftment of hematopoietic stem cell transplants, by selectively depleting endogenous CD45+ cells prior to the transplant procedure.
Patent WO-2022051010-A3 (WO)
Inventor: STIRTZ DANNY
IPC: G01S19/42
Filed: 2021-06-15
Abstract: A positioning, navigation and timing solutions for a ground-based device is determined by receiving a satellite RF signal at the ground-based device. It is determined whether the RF signal is from a satellite of interest. A satellite of interest has known data, enabling an estimation of a current location of the satellite. The RF signal frequency of the satellite of interest is used to collect observed Doppler measurements and time of receipt of the RF signal. The position, navigation and timing solution is determined as a function of the observed Doppler measurements, known data regarding the characteristics of the satellite, and predicted Doppler measurements to enable an estimation of the current location of the receiver.
Patent WO-2022147223-A3 (WO)
Title: 2'-modified nucleoside based oligonucleotide prodrugs
Inventor: MATSUDA SHIGEO
IPC: C07H19/10
Filed: 2021-12-30
Abstract: This invention relates to an oligonucleotide comprising one or more 2'-modified nucleosides, wherein the 2'-position of the nucleoside has a structure of formula (I). The invention also relates to a pharmaceutical composition comprising the oligonucleotide described herein and a method of reducing or inhibiting the expression of a target gene by administering to the subject a therapeutically effective amount of the oligonucleotide described herein. The invention also relates to a method of bioactivating an oligonucleotide comprising one or more 2'-modified nucleosides, wherein the 2'-position of the nucleoside is modified by a bio-cleavable linking group, wherein the bio-cleavable linking group comprises acetal, disulfide, carbamate, amide, sulfonamide, a biocleavable carbohydrate linker, or combinations thereof, said method comprising the step of: exposing the oligonucleotide to a physiological condition that causes the bio-cleavable linking group to be cleaved from the 2'-modified nucleoside, thereby regenerating the 2'-OH group of the nucleoside.
Patent WO-2022173714-A3 (WO)
Inventor: CHEN ZHIFENG
IPC: A61K39/395
Filed: 2022-02-08
Abstract: La présente invention concerne des anticorps anti-métapneumovirus humains (hMPV), ainsi que l'utilisation de ces anticorps dans le traitement d'infections virales. L'invention concerne également des protéines hMPV antigéniques et des compositions immunogènes comprenant de telles protéines hMPV antigéniques, ainsi que l'utilisation de telles protéines hMPV antigéniques et des compositions associées pour prévenir ou traiter une infection virale chez un sujet.
Patent WO-2022198062-A3 (WO)
Title: Derivatives of substituted morpholines and uses thereof
Inventor: PADIA JANAK KHIMCHAND
IPC: A61K31/5375
Filed: 2022-03-18
Abstract: A compound of Formula I includes a stereoisomer thereof and/or a salt thereof; wherein R 1  is a substituted alkane group, a heterocylic group, or a pyridine group; X is hydrogen, a halogen, an amino acid residue, a substituted amino acid residue, an alkyl group, or an ester. Such compounds may be used in pharmaceutical compositions and for the treatment of central nervous system (CNS) disorders:
Patent WO-2022251347-A3 (WO)
Inventor: BASU SOUMITRA
IPC: A61K38/17
Filed: 2022-05-25
Abstract: L'invention concerne de nouvelles compositions à base de molécules d'ADN et des procédés d'administration à des cellules cibles qui fournissent une modulation de la formation de G-quadruplexes cible dans le promoteur de la tyrosine hydroxylase (TH) et permettent d'améliorer ou de réprimer des G-quadruplexes spécifiques qui, à leur tour, régulent la transcription de la tyrosine hydroxylase et la production de catécholamine, spécifiquement la dopamine. L'utilisation des compositions à base de molécules d'ADN dans le traitement de maladies et de troubles neurologiques est facilitée par l'intermédiaire d'un système de distribution à base de nanoparticules.
Patent WO-2022266351-A3 (WO)
Title: Therapeutic oligonucleotide methods
Inventor: LEWARCH CAITLIN
IPC: G16B20/00
Filed: 2022-06-16
Abstract: The invention provides systems and methods for discovering candidate therapies for genetic conditions and also for screening those therapies in vitro for evidence of neurotoxicity. Where a medical condition is a consequence of a genetic target such as a mutated gene, the disclosure provides  in silico  methods to generate lists of candidate sequences for antisense oligonucleotides (ASOs) that will potentially bind to the gene or transcripts from the gene  in vivo  and treat the associated condition by restoring a healthy phenotype of gene expression. The invention provides  in vitro  methods for screening candidate ASO sequences for symptoms of neurotoxicity  in vivo . For example, candidate sequences that are output by the  in silico  analytical pipeline can be synthesized and assayed against live cells  in vitro .
Patent WO-2023009823-A3 (WO)
Title: Electrolytic biocide-generating unit integrated with strainer
Inventor: COSENTINO LOUIS
IPC: B63J4/00
Filed: 2022-07-29
Abstract: A biocide-generating device including a housing having an inlet and an outlet. The biocide-generating device additionally including a strainer basket that mounts within an interior of the housing including parallel electrode plates positioned within an interior of the strainer basket. The biocide generating device additionally including a protective dielectric sleeve in which the electrode plates are received. The protective dielectric sleeve is positioned between the electrode plates and the strainer basket.
Patent WO-2023081484-A3 (WO)
Title: Absolute in vivo radiation dosimetry tool with xact imaging
Inventor: XIANG LIANGZHONG
IPC: A61B8/13
Filed: 2022-11-07
Abstract: The present embodiments relate generally to increasing the precision of radiotherapy by measuring the absolute dose delivered to the tumor and surrounding normal tissue during the treatment. More particularly, some embodiments relate to an imaging reconstruction system for X-ray-induced acoustic computed tomography (XACT) using a model-based reconstruction method. Instead of reconstructing relative dose information for radiation beam localization, the system is capable of reconstructing absolute in vivo dose information. The XACT absolute in vivo dosimetry tool holds great potential for personalized cancer treatment and better outcomes. In some embodiments, thermal parameters, such as Gruneisen parameters, are used to convert reconstructed pressure information to dose. In addition, to avoid problems caused by electrical system gain, calibration tools, such as ion chambers, can be used to calibrate the system.
Patent WO-2023023589-A3 (WO)
Inventor: WEISSMAN DREW
IPC: C07K14/35
Filed: 2022-08-18
Abstract: Provided are nucleoside-modified mRNA molecules encoding tick salivary antigens, and LNP vaccines comprising the mRNA molecules and methods of use thereof to treat or prevent diseases or disorders associated with a tick-borne pathogen including Lyme disease.
Patent WO-2023230413-A3 (WO)
Title: Scores d'incrémentation cumulatifs pour évaluer les performances de modèles d'apprentissage automatique
Inventor: SUMMERHAYS DANIEL
IPC: G06N20/00
Filed: 2023-05-12
Abstract: Un système de conciergerie en ligne utilise un score d'incrémentation cumulative pour évaluer les performances de modèles d'incrémentation utilisés par le système de conciergerie en ligne pour identifier des utilisateurs pour un traitement. Le système de conciergerie en ligne applique un modèle d'incrémentation à un ensemble d'exemples pour générer des scores d'incrémentation prédits pour les exemples. Le système de conciergerie en ligne classe les exemples sur la base des scores d'incrémentation prédits pour les exemples et regroupe les exemples sur la base de leurs classements. Le système de conciergerie en ligne calcule de manière itérative des scores d'incrémentation cumulatifs pour chaque groupement sur la base des exemples de chaque groupement, et calcule un score d'incrémentation cumulative final pour le modèle d'incrémentation sur la base de chacun des scores d'incrémentation cumulatifs.
Patent AT-505147-A4 (AT)
Title: Use of 2-hydroxy-1-(4-sulfo-1-naphthylazo)naphthalene-6,8-disulfonic acid for the preparation of a drug to treat allergic rhinitis or bronchial asthma
Inventor: PICHLER CHRISTIAN
IPC: A61K31/655
Filed: 2007-06-21
Abstract: Use of 2-hydroxy-1-(4-sulfo-1-naphthylazo)naphthalene-6,8-disulfonic acid or its salt (I) for the preparation of a drug to treat allergic rhinitis or bronchial asthma, is claimed. ACTIVITY : Antiallergic; Antiinflammatory; Antiasthmatic. MECHANISM OF ACTION : None given.
Patent SU-886753-A4 (SU)
Inventor: KELLA ZHAN-MISHEL
IPC: C12N1/26
Filed: 1976-03-05
Granted: 1981-11-30
Abstract: The sepn. of a biomass from a fermentation broth contg. biomass, aq. nutrient medium and hydrocarbon is carried out by (a) treating the broth with an anionic surfactant at a pH above that at which the surfactant is ionised but below 3, and centrifuging at 20-40 degrees C (pref. 25-35 degrees C) to obtain a cream comprising biomass, nutrient medium and surfactant, and an emulsion comprising a major amt. of hydrocarbon and a minor amt. of nutrient medium, biomass and surfactant: (b) centrifuging the emulsion at a pH of 4 (pref. ca. 3) and a temp. of 65-100 degrees C (pref. 65-85 degrees C) to obtain a hydrocarbon phase and an aq. phase comprising nutrient medium, biomass and surfactant; and (c) recycling the aq. phase to step (a). The process can be applied to systems for the prodn. of a yeast biomass and dewaxed hydrocarbon from wax-contg. hydrocarbon fees (e.g. gas oils contg. 10-25C n-paraffins). Recycling the sq. phase from the 2nd centrifugation reduces the consumption of surfactant and water, and avoids effluent disposal problems.
Patent AT-501886-A4 (AT)
Filed: 2005-11-17
Abstract: The inner core has foamed material, longitudinal bars and transverse bars. Longitudinal bars (1, 2, 2 ') or transverse bars (3, 3 ', 4, 4 ') have different cross sections in different areas of inner core. Both the longitudinal bars and transverse bars have a larger cross sectional area than the bars lying in between.
Patent EP-1163700-A4 (EP)
Inventor: RUMENNIK VLADIMIR
IPC: H01L29/10
Filed: 2000-01-31
Abstract: Cette invention concerne un procédé de fabrication pour transistor à effet de champ à grille isolée, haute tension (HVFET), qui comprend une structure avec dispositif à effet de champ à grille isolée avec source (14) et drain (19), ledit drain comportant une région élargie de puits (17) avec une ou plusieurs couches enfouies (18) de conduction opposée disposées en sandwich. La ou les couches enfouies (18) créent une pluralité associée de canaux de conduction parallèles à effet de champ à jonction (JFET) dans la région élargie de la région de puits. Les canaux parallèles de conduction à effet de champs à jonction confèrent aux HVFET une faible résistance à l'état passant.
Patent EP-1278586-A4 (EP)
Inventor: EMBREE MICHAEL E
IPC: B31B41/00
Filed: 2000-03-21
Abstract: La présente invention concerne un sac à débris (120) refermable comprenant un corps de sac (22) présentant une ouverture (26), et un élément en forme de plaque (128) fixé au corps de sac (22) à proximité de l'ouverture (26). Des première et seconde parties (150, 152) de l'élément en forme de plaque (128) peuvent pivoter le long d'une ligne de pliage (156) de sorte que la première partie (150) peut s'engager dans la seconde partie (152) pour refermer sensiblement l'ouverture (26). Un volet (129) se trouvant d'un côté de la ligne de pliage (156) s'engage dans une encoche (131) se trouvant de l'autre côté de la ligne de pliage (156) afin de maintenir la fermeture du dispositif. La ligne de pliage (156) peut être formée dans l'élément en forme de plaque (128) de manière à définir les première et seconde parties (150, 152) à l'endroit où les parties sont adjacentes, ou peut être formée dans le corps de sac (22) à l'endroit où les parties ne sont pas adjacentes. L'ouverture (26) peut être formée dans une paroi latérale flexible du corps de sac (22), ou, de manière alternative, dans une partie extrême du corps de sac (22). Une structure d'alignement complémentaire se trouvant sur l'élément en forme de plaque (128), s'accouple avec une structure d'alignement se trouvant sur un aspirateur afin de garantir le bon alignement du sac à débris (120) sur l'aspirateur.
Patent EP-1196550-A4 (EP)
Inventor: RUBINSKY BORIS
IPC: C12N15/87
Filed: 2000-07-20
Abstract: L'invention concerne un courant électrique créé sur un support conducteur qui comporte une cellule pouvant faire partie d'un tissu ou d'un organisme vivant. On mesure un premier paramètre électrique, tel qu'un courant, une tension, ou une impédance électrique. On règle et/ou on analyse ensuite un second paramètre électrique, tel qu'un courant ou une tension ou une combinaison des deux. Des règlements sont effectués afin de faciliter l'analyse et/ou d'obtenir le dégré d'électroporation souhaité. On procède ensuite à une analyse afin de déterminer des caractéristiques de la membrane cellulaire et/ou du tissu.
Patent EP-1202782-A4 (EP)
Title: Injection molded doll head
Inventor: FEKETE FERENC
IPC: B29C45/44
Filed: 2000-08-09
Abstract: The invention provides a method for making a hollow doll's head (10) by injection molding a thermoplastic elastomer around a removable mold core (26). The major dimension of the mold core (26) is larger than the opening in the doll's head (10) through which the core (26) is to be removed after the injection molding is complete. For large mold cores and relatively small openings, the invention provides a multiple piece core section which is designed to be removed piece by piece through the opening in the doll's head (10) and then reassembled for reuse.
Patent EP-1316637-A4 (EP)
Title: Healthy fiber products
Inventor: HIRATA YOSHIHIRO
IPC: A41D31/00
Filed: 2000-11-29
Abstract: A fiber product offering health-enhancing effects is obtained by causing a fibrous substrate to contain or be bonded with finely divided titanium powder through the process of impregnation with a water solution containing finely divided titanium powder, which is obtained by dissolving metallic titanium via the combustion gas produced by combusting a gaseous oxygen/hydrogen mixture in high-pressure water in a pressure-resistant tank. <IMAGE>
Patent EP-1344152-A4 (EP)
Inventor: CHOE MYONGSU
IPC: H04L45/74
Filed: 2001-12-21
Abstract: L'invention concerne un procédé de construction de tables de routage/transmission servant à des consultations d'adresses IP, au moyen d'une liste d'acheminement hors hiérarchie. Le procédé consiste à diviser une plage de longueur d'indicatif d'une adresse IP selon une méthode prédéfinie. Le procédé consiste ensuite à créer un noeud d'en-têtes présentant un niveau maximal basé sur un nombre de blocs divisés à l'intérieur de la plage de longueur d'indicatif, le noeud d'en-têtes pointant chaque noeud dans la liste d'acheminement hors hiérarchie. Le procédé consiste enfin à créer des sous-noeuds par le nombre de blocs divisés, chaque sous-noeud ayant comme clé la plage de longueur d'indicatif divisée.