baber/WOPTO huggingface dataset:
Patent NZ-574699-A (NZ)
Title: 5,6-bisaryl-2-pyridine-carboxamide derivatives, preparation and application thereof in therapeutics as urotensin ii receptor antagonists
Inventor: VERNIERES JEAN CLAUDE
IPC: A61P9/00
Filed: 2007-08-09
Abstract: Disclosed is a biaryl compound comprising at least one phenyl ring and possibly a pyridine or a pyrazine of formula (I) where the substituents are as disclosed in the description. Also disclosed is a process for making compounds of formula (I), a medicinal produce or pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) for the preparation of a medicament for treating or preventing congestive heart failure, ischaemic heart disease, myocardial infarction, cardiac hypertrophy and fibrosis, coronary diseases and atherosclerosis, systemic and pulmonary arterial hypertension, post-angioplasty restenosis, acute and chronic renal failure of diabetic and/or hypertensive origin, diabetes, inflammation, fibroses and aneurysms, disorders of the central nervous system, including neurodegenerative diseases, cerebrovascular accidents, stress, anxiety, aggressiveness, depression, schizophrenia or sleep disorders and cancers or respiratory diseases, asthma or vomiting. Examples of compound of formula (I) include: 1-({ [6-{ 4-chloro-3-[3-(dimethylamino)propoxy]pheny1} -5-(5-methyl-1,3-thiazol-4-yl)pyridin-2-ylicarbonyl} amino)cyclohexanecarboxylic acid hydrochloride; 1-({ [3-chloro-2'-(4-chloro-3-{ 3-[ethyl(methyl)amino]propoxy} pheny1)-2,3'-bipyridin-6'-yl]carbonyl} amino)cyclohexanecarboxylic acid hydrochloride and 1-({ [6-(4-chloro-3-{ 3-[ethyl(methyl)amino]propoxy} pheny1)-5-(2-methylphenyl)pyridin-2-yl]carbonyllamino)-4-hydroxycyclohexanecarboxylic acid hydrochloride.
Patent NZ-574936-A (NZ)
Title: Portable pumping apparatus for concurrently pumping liquid from a source container to a destination container and pumping vapor from the destination container to the source container
Inventor: BONNER MARK
IPC: F04B15/00
Filed: 2007-07-18
Abstract: A portable pump 210 pumps fuel from a source container to a destination container and concurrently pumps fuel vapour back from the destination container to the source container. The pump 210 has a liquid inlet 223a, a liquid outlet, a piston 232, a vapour inlet and a vapour outlet 226a. The upward stroke of the piston 232 draws fuel from the source container into the pump 210 through the fuel inlet 223a and pushes the vapour out of the pump 210 to the source container through the vapour outlet 226a. The downward stroke of the piston 232 draws the vapour from the destination container into the pump through the vapour inlet and pushes the fuel out of the pump to the destination container through the liquid outlet.
Patent NZ-575573-A (NZ)
Title: Derivatives of pyrrolizine, indolizine and quinolizine, preparation thereof and therapeutic use thereof
Inventor: DARGAZANLI GIHAD
IPC: C07D471/04
Filed: 2007-09-21
Abstract: Disclosed is a compound, e.g. trans-erythro-2-chloro-N-[(octahydroindolizin-5-yl)phenylmethyl]-3-trifluoromethylbenzamide hydrochloride in the form of a pure enantiomer or of an erythro or threo diastereoisomer or of a mixture of such isomers, corresponding to the general formula (I) in which: m and n each represent, independently of one another, the number 1 or 2, Ar represents a group chosen from the phenyl, naphth-1-yl, naphth-2-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, furan-2-yl, furan-3-yl, thien-2-yl, thien-3-yl, thiazol-2-yl and oxazol-2-yl groups, R represents either a hydrogen atom or one or more substituents, identical to or different from one another, chosen from halogen atoms and mono- or polyfluoroalkyl and mono- or polyfluoroalkyloxy, alkyl, alkoxy, alkylthio, cyano, amino, phenyl, acetyl, benzoyl, alkylsulphonyl, carboxyl, alkoxycarbonyl and pentafluorosulphanyl groups, in the form of the base, an addition salt with an acid and/or a solvate or hydrate for the treatment of behavioural disorders associated with dementia, psychoses and acute or chronic extrapyramidal symptoms induced by neuroleptics for the treatment of various forms of anxiety, panic attacks, phobias, obsessive-compulsive disorders, for the treatment of various forms of depression for the treatment of disorders due to alcohol abuse or withdrawal, disorders of sexual behaviour, eating disorders, for the treatment of migraine of generalised epilepsy, secondary generalised epilepsy, partial epilepsy with a simple or complex symptomatology, mixed forms and other epileptic syndromes, in complementing another antiepileptic treatment or in monotherapy. Also disclosed is a process for the preparation of said compound, wherein a nitrile is reacted with a lithiated aryl in an ethereal solvent, between -90 degrees C and -30 degrees C, in order to obtain an intermediate imine which is reduced to the primary amine e.g. trans-threo/erythro-1-(octahydroindolizin-5-yl)-1-phenylmethanamine by a reducing agent, in a protic solvent, between 0 degrees C and ambient temperature, and then an amide coupling is carried out between the diamine and an activated aryl acid or an acid chloride.
Patent NZ-575964-A (NZ)
Title: Block copolymer for drug complex and pharmaceutical composition
Inventor: BOBE IULIAN
IPC: A61P35/00
Filed: 2007-10-19
Abstract: Disclosed is a block copolymer for a drug conjugate, said copolymer comprising a water-soluble polymer region consisting of polyethylene glycol and a polyamino acid region having a hydrazide group and a hydrophobic group in the side chain, wherein the block copolymer comprises the structure of formula (I) or (II) wherein R1, which may be the same or different, represents a hydrogen atom, a methoxy group, a methyl group, or a substituted linear or branched or cyclic C1-C12 alkyl group, in which the substituent represents a functional group selected from the group consisting of a maleimide group, an amino group, a carboxyl group, a thiol group, a hydroxy group and an active ester group which may be protected, R2 represents a hydrogen atom, a saturated or an unsaturated C1-C30 aliphatic carbonyl group or an arylcarbonyl group, R3 represents -O-R5 or -NH-R5 in which R5, which may be the same or different, represents a hydrophobic group, and R4 represents a hydroxy group, a saturated or an unsaturated C1-C30 aliphatic oxy group or an aryl-lower alkyloxy group, L1 and L2 independently from each other represents a linker, m represents an integer of 5-1000, n represents an integer of 0-1000, p represents an integer of 1-1000, and q represents an integer of 1-1000, provided that when units having a hydrophobic group in the side chain account for 20% or more to less than 90% of the total units of the polyamino acids in the block copolymer and units having a carboxylic acid group in the side chain are present, then the units having a carboxylic acid group in the side chain, units having a hydrophobic group in the side chain, and units having a hydrazide group in the side chain are randomly distributed throughout the polyamino acid region, and when units having a carboxylic acid group in the side chain are absent, then units having a hydrophobic group in the side chain and units having a hydrazide group in the side chain are randomly distributed throughout the polyamino acid region, and y represents an integer of 1 or 2.
Patent NZ-577214-A (NZ)
Title: Fused substituted aminopyrrolidine derivatives useful as antibacterial reagents
Inventor: KOMORIYA SATOSHI
IPC: C07D215/22
Filed: 2007-12-28
Abstract: Disclosed herein are fused substituted aminopyrrolinidine derivatives of formula I), wherein Q represents a structure of formula (II) and further substituents are as defined within the specification. Also disclosed are processes for their preparation, wherein said compounds are useful as medicines, veterinary medicines, fishery medicines or antibacterial preservatives.
Patent NZ-578162-A (NZ)
Title: Phosphoinositide 3-kinase inhibitor compounds and methods of use
Inventor: BAYLISS TRACY
IPC: A61P35/00
Filed: 2007-12-05
Abstract: Provided is a compound of formula Ia or Ib, with specified substituents, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof. The compound is a phosphoinositide-3 (PI3) kinase inhibitor and can be used to treat various hyperproliferative diseases, including cancer, conditions involving cell death, infectious diseases and CNS disorders, among others.
Patent NZ-580921-A (NZ)
Title: Sealing and thermal accommodation arrangement in led devices
Inventor: WILCOX KURT S
IPC: F21V5/00
Filed: 2008-04-30
Abstract: An LED apparatus (10,42) includes a mounting board (12), an LED device (16) thereon defining a light-emission axis (32), a lens member (20) axially aligned over the LED device and establishing a light path therebetween, a cover (26) and a resilient gasket member (22). The lens member includes a lens portion and a flange (38) thereabout. The cover has an opening aligned with the light path and securing the lens member over the LED device. The lens member is axially movable in response to LED-device thermal expansion during operation. The resilient gasket member is between the cover and the flange and the cover presses the gasket and the flange of the lens member toward the mounting board. The resilient gasket member is axially compressible permitting axial movement of the lens member caused by thermal expansion during operation. Also disclosed is an LED apparatus (10, 42) including a mounting board (12), a plurality of spaced-apart LED devices (16) thereon each defining a light-emission axis (32), and a plurality of lens members (20) each axially aligned over a respective LED device and establishing a light path therebetween, a cover (26) and a resilient gasket member (22). Each lens member includes a lens portion and a flange (38) thereabout. The cover has openings each aligned with a corresponding light path and securing each lens member over the respective LED device. The lens members are axially movable in response to LED-device thermal expansion during operation, and The resilient gasket member is between the cover and the flanges and the cover presses the gasket and the flange of each lens member toward the mounting board. The resilient gasket member is axially compressible permitting axial movement of the lens members to maintain lens alignment and stability of the LED apparatus. The resilient gasket member provides a weather-proof seal about each of the LED devices which accommodating axial movement of the lens members.
Patent NZ-581165-A (NZ)
Title: Heteroarylamide pyrimidone compounds
Inventor: LOCHEAD ALISTAIR
IPC: A61K31/513
Filed: 2008-05-14
Abstract: Disclosed is a pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof wherein: X represents two hydrogen atoms, a sulphur atom, an oxygen atom or an alkyl group and a hydrogen atom; Z represents a bond, an oxygen atom, a nitrogen atom substituted by a hydrogen atom or an alkyl group, a sulphur atom, a methylene group; R1 represents a 2, 4 or 5-pyrimidine ring or a 4-pyridine ring; R2 represents a heterocyclic group, R3 represents a hydrogen atom, an alkyl group or a halogen atom; R4 represents a hydrogen atom or an alkyl group; R5 represents a hydrogen atom, an alkyl group; R7 represents a hydrogen atom or an alkyl group; and n represents 0 to 3 and m represents 1 in the form of a free base or of an addition salt with an acid exemplified by [1,5]Naphthyridine-2-carboxylic acid [Z-(1-methyl-6-oxo-1,6-dihydro- [4,4']bipyrimidinyl-2-yl)-ethyl]-amide, 6-Chloro-pyridine-2-carboxylic acid [Z-(1-methyl-6-oxo-1,6-dihydro- [4,4']bipyrimidinyl-2-yl)-ethyl]-amide and 2-Methoxy-N-[2-( 1-methyl-6-oxo-1 ,6-dihydro-[4,4']bipyrimidinyl-2-yl)-ethyl]-amide in treating Alzheimer's disease, Parkinson's disease, tauopathies, vascular dementia; acute stroke, traumatic injuries; cerebrovascular accidents, brain cord trauma, spinal cord trauma; peripheral neuropathies; retinopathies or glaucoma, noninsulin dependent diabetes; obesity; manic depressive illness; schizophrenia; cancers; parenchymal renal diseases or muscle atrophy and malaria. Also disclosed is a process to make said derivative by coupling a pyrimidone amine with a carboxylic acid derivative in basic conditions.
Patent NZ-581862-A (NZ)
Title: Injectable subcutaneous formulation comprising risperidone capable of forming a solid, microporous implant in a patient
Inventor: DADEY ERIC
IPC: A61K31/519
Filed: 2008-02-13
Abstract: Disclosed is a flowable composition which comprises: (a) a biodegradable thermoplastic polymer that is at least substantially insoluble in body fluid (such as a poly(DL-lactide-co-glycolide)), and wherein said biodegradable thermoplastic polymer is a polyester of one or more hydroxycarboxylic acids, or is a polyester of a combination of one or more diols and one or more dicarboxylic acids; (b) a biocompatible polar aprotic organic liquid that is highly water soluble and which comprises an amide, an ester, a carbonate, a ketone, an ether, a sulfonyl, or any combination thereof (and which is preferably selected from N-methyl-2-pyrrolidone, 2-pyrrolidone, N,N-dimethylformamide, dimethyl sulfoxide, caprolactam, or combinations thereof); and (c) risperidone, 9-hydroxyrisperidone or a pharmaceutically acceptable organic or inorganic salt thereof; and wherein the flowable composition is an injectable subcutaneous formulation capable of forming a solid, microporous implant in a patient by diffusion of the biocompatible polar aprotic organic liquid out of the flowable composition into the body fluid, so that the flowable composition coagulates to form the implant.
Patent NZ-584892-A (NZ)
Title: Quinolone analogs and methods related thereto
Inventor: NAGASAWA JOHNNY YASUO
IPC: A01N55/02
Filed: 2008-10-03
Abstract: Disclosed are quinolone compounds represented by general formula (I) which inhibit cell proliferation and reduce or ameliorate microbial infection.
Patent NZ-586154-A (NZ)
Title: Pair of gates each rotatable about a horizontal axis and coupled via meshed interconnection to rotate in opposite directions.
Inventor: MCDOUGAL GRAEME DAVID
IPC: E05F17/00
Filed: 2011-09-13
Abstract: A coupled pair of gates (1, 5) is locatable at a gate position with each gate being rotatable about a respective substantially horizontal pivot axis (4, 7). In a closed position the gates are able to prevent passage of a selected type of animal past the gate position and in an open position such an animal is able to pass the gate position. The pivot axes (4, 7) are adjacent and there is a meshed driving interconnection between the gates. The meshed driving interconnection acts so that as one gate (1) is rotated about its pivot axis (4) the other gate (5) is driven to swing about its pivot axis (7) in substantially the opposite direction.
Patent NZ-589890-A (NZ)
Title: New Antitumoral Compounds comprising modified kahalalide F
Inventor: PALOMERA FERNANDO ALBERICIO
IPC: C07K7/08
Filed: 2004-09-09
Abstract: Disclosed is a compound of formula (1) based on the structure of kahalalide F, wherein the kahalalide F structure is modified at the 5-Mehex 14 position with an octanoic acid group. Also disclosed is the use of the compound of formula (1) for treating cancer.
Patent NZ-590948-A (NZ)
Title: Solid pharmaceutical composition comprising a diuretic, ph control agent and an oxadiazole
Inventor: TANOUE YUTAKA
IPC: A61K31/4245
Filed: 2009-07-29
Abstract: Disclosed is a solid preparation comprising a compound selected from (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl-2-ethoxy-1-{ [2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl} -1H-benzimidazole-7-carboxylate or a salt thereof, a pH control agent having a pH of 2 to 5 and a diuretic. The solid preparation has improved stability and dissolution properties.
Patent NZ-591947-A (NZ)
Title: Breathing apparatus which synchronises the blower and the patients respiratory cycle
Inventor: FARRUGIA STEVEN PAUL
IPC: A61B5/08
Filed: 2004-06-18
Abstract: An apparatus for delivering breathable air to a patient throughout the patient's respiratory cycle, the respiratory cycle including an inhalation phase and an exhalation phase, the apparatus comprising a blower having an electric motor 10 configured to rotate an impeller 12 within a volute 36, a patient interface 18, an air delivery conduit 16 arranged to deliver breathable air from the blower to the patient interface 18, at least one sensor adapted to provide a signal to detect the transition between the inhalation phase and the exhalation phase, a controller 14 to control the pressure of breathable air delivery to the patient interface 18 between a comfort pressure during at least a portion of the exhalation phase and a therapeutic pressure during at least a portion of the inhalation phase, and a synchrony means. The synchrony means will predict when the inhalation phase and/or the exhalation phase will occur based upon the signal determined from the sensor and will coordinate an adjustment in pressure between the comfort pressure and the therapeutic pressure to maintain synchrony between the blower and the patient's respiratory cycle
Patent NZ-592351-A (NZ)
Title: Cheese vat with multiple rennet injection points with various alignments
Inventor: ISENBERG TIMOTHY J
IPC: F16K21/02
Filed: 2011-04-19
Abstract: Disclosed is a rennet injection system within a food processing vessel or vat that provide improved rennet mixing and distribution. The system comprises a vat with multiple interconnected walls defining an inside or interior space or volume of the vat. The vat has a longitudinal centre line axis and a rennet supply line for conveying rennet to the inside space of the vat. The rennet supply line contains multiple injectors spaced from each other, the multiple injectors extend into the inside space of the vat. A pair of agitator shafts that extend through the inside space of the vat, on opposing sides of the centre-line of the vat; and a rennet receiving area between the pair of agitator shafts includes multiple rennet delivery locations that are spaced apart so that some of the rennet locations are aligned with each other and are arranged along the centre-line of the vat and other rennet delivery locations are arranged on opposing sides of the centre-line of the vat. Each injector has multiple openings or spray nozzles that face different directions transversely across and longitudinally along the vat to deliver the rennet in a pattern that is generally evenly distributed through the rennet receiving area.
Patent NZ-593320-A (NZ)
Title: An annular fan assembly with a down stream diffuser
Inventor: CRAWFORD TOM
IPC: F04D25/08
Filed: 2010-02-18
Abstract: A fan assembly 10, for creating an air current, comprises a nozzle 14 mounted on a base. The base comprises an outer casing, an impeller housing 64 located within the outer casing, the impeller housing 64 having an air inlet 70 and an air outlet, an impeller 52 located within the impeller housing and a motor 56 for driving the impeller to create an air flow through the impeller housing 64. The nozzle 14 comprises an interior passage 86 for receiving the air flow from the air outlet of the impeller housing 64 and a mouth 26 through which the air flow is emitted from the fan assembly 10. A flexible sealing member is located between the outer casing and the impeller housing 64. The flexible sealing member may be connected to the impeller housing 64 and biased against the outer casing. The sealing member may comprise an annular seal surrounding the impeller housing.
Patent NZ-597050-A (NZ)
Title: Pyrimidinones as pi3k inhibitors
Inventor: LI YUN-LONG
IPC: A61K31/429
Filed: 2010-06-28
Abstract: 597050 Disclosed are thiazolopyrimidinones of formula I, for example 3-methyl-6-phenyl-7-[1-(9H-purin-6-ylamino)ethyI]-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders and cancer.
Patent NZ-598183-A (NZ)
Title: Deepwell plate system with lid
Inventor: STETTLER MATT
IPC: B01L3/00
Filed: 2010-08-14
Abstract: 598183 A deepwell plate system includes a deepwell plate comprising a frame and 24 or 96 deepwells, wherein at least one well comprises at least one inner structure, and a lid system, comprising an inner cover, at least one filter membrane and an outer cover. The outer cover covers simultaneously all of the openings of the deepwells and includes at least one integrated lock element as a first locking portion in the form of a snap fastener that can be detachably fitted to at least one second locking portion located on the frame of the deepwell plate.
Patent NZ-599554-A (NZ)
Title: ((phenyl)imidazolyl)methylheteroaryl compounds
Inventor: SINHA SANTOSH C
IPC: A61K31/4178
Filed: 2008-05-13
Abstract: Abstract 599554 Disclosed herein is imidazole compound of formula I wherein A is substituted pyridyl, thienyl, furyl, pyrrolyl, imidazolyl, oxazoyl, pyrazolyl, pyrimidinyl or pyrazinyl having 0-3 substituents and B is phenyl having 0-3 substituents. Therapeutic methods, compositions, and medicaments related thereto are also disclosed. Particular uses anticipated include the treatment of pain.
Patent NZ-600458-A (NZ)
Title: Method and apparatus for microwave-based liquid vaporization system
Inventor: NOVAK JOHN F
IPC: B01J19/12
Filed: 2010-12-07
Abstract: An apparatus and process for improving fuel vaporization combustion efficiency and reducing soot in combustion chambers is disclosed. The apparatus comprises at least one microwave generator (10) and a generally rectangular waveguide (22) having a standing microwave of approximately 915 MH. An essentially microwave-transparent ceramic tube (16) is positioned at least partially within the waveguide (22) and is exposed to the standing wave. The device includes a microwave frequency adjustment tuner assembly (12) to match output impedance of the microwave generator (10) to a liquid organic-containing material pumped through the ceramic tube. A power density monitor measures applied and reflected power within the waveguide (22) by at least one sampling diode mounted in the waveguide and the power measurement is usable to minimize the reflected power by adjustment the tuner (12). The process and apparatus are used to process biodiesel by-products for use as liquid fuel.
Patent NZ-602578-A (NZ)
Title: Polymorphic forms st-246 and methods of preparation
Inventor: TYAVANAGIMATT SHANTHAKUMAR R
IPC: A01N43/42
Filed: 2011-03-23
Abstract: The disclosure relates to polymorph forms of 4-trifluoromethyl -N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f] isoindol-2(1H)-yl)-benzamide (named ST-246) as well as their methods of synthesis and pharmaceutical compositions. These polymorph forms of said compound are suitable for treating Orthopoxvirus infections and eczema vaccinatum.