baber/WOPTO huggingface dataset:
Patent JP-H11504539-A (JP)
IPC: A61B18/14
Filed: 1996-04-30
Abstract: Systems and methods ablate body tissue using an electrode for contacting tissue at a tissue-electrode interface to transmit ablation energy at a determinable power level. The systems and methods include an element to remove heat from the electrode at a determinable rate. The systems and methods employ a processing element to derive a prediction of the maximum tissue temperature condition occurring beneath the tissue-electrode interface. The processing element controls the power level of ablation energy transmitted by the electrode, or the rate at which the electrode is cooled, or both, based, at least in part, upon the maximum tissue temperature prediction.
Patent JP-2000508046-A (JP)
IPC: F16F1/38
Filed: 1996-12-06
Abstract: Mechanical coupling for elastic axial and radial constraint with torsional freedom, especially for elastic pivots and suspensions and the like, comprising, according to the invention, a composite tubular member made of metal and elastomer (11) that exhibits high axial and radial rigidity and the ability to absorb vibrations induced by the mechanical system in which it is fitted and to compensate for manufacturing tolerances in that system, and a tubular insert (15), made of nonwear plastic material with a low coefficient of friction which is coaxial and integral, in the form of a fixed inner sleeve, with said composite tubular member (11) and engages with a rotating metallic component (16) fitted coaxially with respect to said tubular insert to provide the torsional freedom.
Patent JP-2000510601-A (JP)
Title: ビデオディスプレイとイメージ増倍システム
IPC: H01J31/50
Filed: 1996-08-05
Abstract: (57)【要約】
ビデオソース（１２）とサブストレート（１８）を有するイメージ増倍管（１４）を利用したビデオディスプレイシステム。ビデオ画像源（１２）は光子信号（２２）を提供するためにサブストレートに位置する。サブストレートの光電陰極エレメント（３８）は光子信号を電子に変換する。第１第２面を有する光学的に透明な物体（１８，２４）は、そこから間隔を置いて並べられるサブストレートの反対に位置する。サブストレートと光学的に透明な第２物体の第１面との間に、真空チェンバ（３２）が形成される。蛍光層は、光学的に透明な第２物体の該第１面上に位置する。電力源（４４）は光電陰極層（３８）と蛍光層（４０）との間に、電圧電位を提供する。増倍されたビデオイメージが光学的に透明な第２物体（２８）の第２面から出てビューイングされる。
Patent JP-2001512371-A (JP)
IPC: B22D11/106
Filed: 1998-02-12
Abstract: Method of preventing contact of oxygen with a metal melt during continuous casting, the metal melt flows into a casting chamber bounded by rolls and a hood and leaves this chamber as a stream. To completely prevent contact of oxygen with the metal melt and thus reoxidation, oxygen attempting to enter via any gaps between the walls and/or adhering to the walls is removed by suction applied at a succession of suction stages at the periphery of each roll before a gap between the hood and the roll at the top of the casting chamber. Inert gas may then flow to the rolls near the gap.
Patent JP-H11506486-A (JP)
Title: アルコールのデリバリー用のベタインエステル
IPC: A23L27/00
Filed: 1996-05-13
Abstract: (57)【要約】
本発明は、ａ）化合物（１）、ｂ）化合物（５）、ｃ）化合物（６）、ｄ）化合物（７）およびｅ）化合物（８）から選択される一般式の化合物を含んでなる組成物に関する。上記組成物は、Ｒ基の遅延放出により追随される、表面への優れた付着性を示す。更に詳しくは、本発明は、放出性Ｒ基としてゲラニオールのような香気性アルコールを有する、ベタインエステル四級アンモニウム誘導体に関する。ａ）−化合物（１）
 ｂ）−化合物（５）
 ｃ）−化合物（６）
 ｄ）−化合物（７）
 およびｅ）−化合物（８）
Patent JP-2001500641-A (JP)
Title: 並列データプロセッサにおけるアクティブ命令を回転させる方法および装置
IPC: G06F9/38
Filed: 1996-05-31
Abstract: (57)【要約】
マイクロプロセッサにおいて、本装置および方法は、選択された発行順序命令の発行およびデスパッチに先立って、多重フェッチ命令を発行順序に回転することによって命令のフェッチおよび発行をコーディネートする。回転およびデスパッチブロックは、新しくフェッチされた命令を物理的メモリ順序で既にフェッチされているが発行されていない命令とミックスするためのミキサと、該ミックスされた命令を発行順序に回転するためのミックスおよび回転装置と、デスパッチに先立って発行順序命令を保持する命令ラッチとおよび、新しくフェッチされた命令とミックスする前に、非発行命令を発行順序から物理的メモリ順序に回転させるための回転解除装置を含んでいる。フェッチサイクルの期間、多重命令は記憶装置から物理的メモリ順序で同時にフェッチされ、かつ回転およびデスパッチブロック内でＰＣ関連発行順序に回転させられる。次のクロックサイクルにおいて、既にフェッチされ回転された命令の選択されたものが、発行サイクルに入り、新しい命令セットが物理的メモリ順序でフェッチされ、既にフェッチされかつ回転されているが発行されていない命令が物理的メモリ順序に再配列されかつ新しくフェッチされた命令と物理的メモリ順序でミックスされ、同時に全てのフェッチされた命令および非発行命令が次の発行サイクルに先立って発行順序で回転され、さらに全命令がパイプラインを通過するまで、これが続けられる。
Patent JP-2000510688-A (JP)
Title: ストレプトコッカス・ニューモニアエのアスパルチルｔＲＮＡシンセターゼ
IPC: A61K39/02
Filed: 1997-04-18
Abstract: (57)【要約】
本発明は、ａｓｐＳポリペプチドおよびａｓｐＳポリペプチドをコードするＤＮＡ（ＲＮＡ）、ならびに組み換え法によるかかるポリペプチドの製造方法を提供する。抗細菌化合物のスクリーニングのためのａｓｐＳポリペプチドの使用方法も提供する。
Patent JP-H11510019-A (JP)
Title: 通信ネットワーク、通信システム及びそのようなシステム用のユニットに対するアクセス制限処理
IPC: H04L9/32
Filed: 1997-04-21
Abstract: (57)【要約】
本発明は通信ネットワークに対する端末のアクセスの制限処理に関する。本発明は特に例えば呼の受け手、その時間、その間隔等々のようなある基準に関してアクセスのユーザーの権利を確認するためにユーザーを認証するための通信システムで通常実行されている現在のユーザー認証手続きを用いる。本発明は例えばＤＥＣＴ規格用の移動電話方式で特に好ましく応用される。
Patent JP-2002501637-A (JP)
IPC: G10L15/32
Filed: 1998-03-10
Abstract: Disclosed is a method for classifying samples wherein the information content of a sample is divided up into two information areas. The first area contains necessary information and the second area contains sufficient information. An initially imprecise preselection concerning a plurality but extremely limited number of classes is made through the necessary information area. After said preselection, identification occurs with the sufficient information area in order to pinpoint the initially imprecise preselection in relation to an effective target class. This enables classification quality to be improved by means of new classifiers or new principal formulations of classification formulations.
Patent JP-2001523429-A (JP)
Title: Ａｄｃ／ｄａｃ複合センサ・システムを備える信号調整回路およびその方法
IPC: H03M1/02
Filed: 1998-12-18
Abstract: (57)【要約】
電子的に較正されるセンサ１００は、信号調整回路１０４に結合される出力を有する検知素子１０２を備える。信号調整回路１０４は、検知素子出力上の温度および部分間変動を補償するように演算効率が高く動作可能であり、利用可能なセンサ出力信号を提供する。信号調整回路１０４は、アナログ−デジタル／デジタル−アナログ（ADC/DAC）変換装置１１２を備える。ADC/DAC１１２は、アナログ入力信号のアナログ−デジタル変換とデジタル出力信号のデジタル−アナログ変換の両方を実行することができる。ADC/DAC１１２は、さらに、アナログ信号を入力信号調整回路１０４，１０６に提供する。
Patent JP-2001517931-A (JP)
IPC: C07K14/47
Filed: 1997-04-22
Abstract: Disclosed is a novel gene termed ART which is expressed primarily in selected regions of the brain, as well as adrenal and lung tissues. Polypeptides encoded by ART are also disclosed, as are methods for preparing ART DNA and amino acid sequences.
Patent JP-2000510228-A (JP)
IPC: B01D53/38
Filed: 1997-05-08
Abstract: PCT No. PCT/US97/08009 Sec. 371 Date Oct. 27, 1998 Sec. 102(e) Date Oct. 27, 1998 PCT Filed May 8, 1997 PCT Pub. No. WO97/43527 PCT Pub. Date Nov. 20, 1997A regenerative thermal oxidizer (H-101) includes a number of heat exchange columns (A, B) topped by a combustion chamber (C-101). Contaminated air is directed into one of the columns and oxidation is completed as the flow passes through the combustion chamber (C-101). From the combustion chamber (C-101), the now clean air flows vertically downward through another column and then is directed via an outlet through an outlet manifold and released to atmosphere or recirculated back to the oxidizer (H-101). A combustible fuel is added to the contaminated air prior to its entry into one of the columns. The addition of the combustible fuel is regulated by continuously monitoring the inlet and outlet temperatures (TE-101A, TE-108A), and comparing a difference between these temperatures to a predetermined value. Further control can be achieved by measuring the flow of contaminated air to the oxidizer (H-101) via pressure differential and coordinating that measurement with the temperature differential measurement.
Patent JP-2001517994-A (JP)
Title: 光を用いる角質層の除去
IPC: A61B18/18
Filed: 1998-03-20
Abstract: (57)【要約】
光源、好ましくはレーザー、より好ましくはパルスレーザーを用いて角質層の透過性を高める方法。角質層の透過性を高めることにより、間質液に接近することができ、これにより間質液中のアナライトを分析することができる。１つの要旨では、前記方法は（ａ）約９３０ｎｍ〜約１０４０ｎｍの波長を有する光源を用意するステップ、及び（ｂ）患者の角質層に開口を形成するのに十分な時間患者の角質層の領域を前記光源に露出させるステップを含む。好ましくは、角質層の領域の光源への露出を、角質層の開口を占める間質液の表面から反射した光の散乱強度と間質液が実質的に存在しない角質層の領域から反射した光の散乱強度とに違いを生じさせるのに十分な量の間質液が角質層の開口に満ちたときに中止する。本発明は、前記方法を実施するための装置をも包含する。
Patent JP-2002501457-A (JP)
Title: 車両センサ装置
IPC: B60R21/16
Filed: 1998-03-04
Abstract: (57)【要約】
車両のための安全システムは、車両のエアバッグの前方の少なくとも一部における保護空間を規定する車両の内側部分において、少なくとも一つの領域（２２）を検知するための少なくとも一つのセンサ（２０）と、少なくとも一つのセンサ（２０）に応答して、保護空間内における物体（１５１）の形状データを決定するための論理回路とを有している。
Patent JP-2001524008-A (JP)
IPC: A61F2/82
Filed: 1998-05-01
Abstract: A filter device for capturing embolic material in a blood vessel, comprising: 
a substantially flexible sheath (32) having a distal end (36), a proximal end, a distal region, and a proximal region, and having a lumen (33) extending between the distal end (36) and the proximal end; 
a guidewire being slidably insertable into the lumen (33) of the sheath (32) and longitudinally movable relative to the sheath (32); and 
an expandable filter assembly (50) mounted on the distal region of the guidewire (40),  
wherein the expandable filter assembly (50) comprises a filter mesh (60) and a single strut (54), wherein said strut (54) is connected at its proximal end (56) to the distal end (42) of guidewire (40) and connected at its distal end (58) to filter mesh (60) of filter assembly (50).
Patent JP-2002503358-A (JP)
Title: アクティブマトリックス液晶表示装置
IPC: G09G3/20
Filed: 1999-03-29
Abstract: (57)【要約】
選択パルス信号を順次供給する行アドレス導体（１４）とデータ信号を供給する列アドレス導体（１６）の組に接続された各トランジスタ（１１）を経てアドレス指定された表示素子（１２）のアレイと、各表示素子および関連するトランジスタを接続する導体に隣接する行導体間に接続され、各行導体に供給された波形のステップレベルが最終表示素子電圧に寄与する容量結合駆動モードで作動し得る蓄積コンデンサ（１８）とを有するアクティブマトリックス襟章表示装置において、各行導体に供給される行駆動波形は選択パルスの前後の双方にステップレベルを含むようにする。これにも係わらず使用する垂直走査方向を容易に反転し得るようにするとともに有利なドット反転駆動方式を用い得るようにする。
Patent MD-20010264-A (MD)
Inventor: BRAILA MARIN GRIGORE
IPC: F01C1/00
Filed: 2001-08-03
Abstract: Inventia se refera la constructia de masini, si anume la instalatii destinate pentru transformarea energiei potentiale a lichidului sau a mediilor fluide comprimabile in energie mecanica si viceversa, si poate fi aplicata in actionari hidraulice si pneumatice, in motoare cu ardere interna cu formare exterioara sau interioara a amestecului, precum si in motoare cu ardere externa, in masini cu vid, in contoare volumetrice pentru lichid si pentru medii fluide comprimabile. Masina contine rotorul 5 cu amplasarea coaxiala in corpul 1 a doi cilindri - interior 7 si exterior 8, uniti printr-un perete transversal 9 si printr-un perete despartitor 10, in care este executat un canal interior 22 pentru comunicarea cavitatilor (ŕ) de volum variabil cu colectorul interior si un canal exterior pentru comunicarea cavitatilor (d) de volum variabil cu colectorul exterior, precum si un rotor-separator 19 care include un cilindru separator 20 si discul frontal 21, axa de rotatie a caruia este situata excentric in raport cu axa de rotatie a rotorului 5, totodata, cand cavitatile (ŕ) de volum variabil unite cu colectorul interior se maresc permanent, cavitatile (d) de volum variabil unite cu colectorul exterior se micsoreaza permanent. In peretele lateral al corpului 1 este executat orificiul 18, in fusul 12 al arborelui de actionare - orificiul axial 17, iar in capacul distribuitor 15 pentru curgerea agentului de lucru - orificiul 16. ŕ
Patent NZ-202555-A (NZ)
Title: Lift for personnel or goods raised and lowered by cable & pulley mounted on hydraulic cylinder & piston arrangement
Inventor: COOPER N G
IPC: B66B9/04
Filed: 1982-11-19
Abstract: PCT No. PCT/AU82/00194 Sec. 371 Date Jul. 18, 1983 Sec. 102(e) Date Jul. 18, 1983 PCT Filed Nov. 22, 1982 PCT Pub. No. WO83/01938 PCT Pub. Date Jun. 9, 1983.A lift or elevator for goods or passengers suitable for installation to existing low rise residential or commercial buildings. The lift comprises an upright hollow column (40) having a slot extending along the length of one face (47) thereof, a carriage (50) slidably mounted within the column on tracks (48), a cantilever beam assembly (54) supporting a lift car (55) attached by brackets (52, 53) to the carriage through the slot, a hydraulic ram (60) mounted within the column beneath the carriage and a cable (66) attached to a retaining member (67) at one end, and, via a pulley (63), to the carriage at the other end for elevation thereof. An electrical control circuit, an hydraulic control circuit as well as a method of installing the lift are also disclosed.
Patent NZ-208386-A (NZ)
Title: 2-(n-(1-carboxyalkyl)alanyl isoindol-1-ylcarboxylic acids and pharmaceutical compositions
Inventor: VINCENT M
IPC: A61P9/12
Filed: 1984-06-05
Abstract: 1. Claims for the contracting states : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Compounds corresponding to the general formula I :  see diagramm : EP0129461,P7,F5  in which the ring A is saturated or, alternatively, benzenic, R represents a hydrogen atom or a lower alkyl group having from 1 to 4 carbon atoms, R' represents a linear alkyl radical having from 1 to 6 carbon atoms or a mono- or di-cycloalkyl-alkyl radical having from 4 to 7 carbon atoms, in their racemic form or in the form of optical isomers, and the salts thereof obtained with a therapeutically compatible mineral or organic base or the addition salts thereof obtained with a pharmaceutically compatible mineral or organic acid. 1. Claim for the contracting state : AT Process for the preparation of compounds corresponding to the general formula I :  see diagramm : EP0129461,P7,F6  in which the ring A is saturated or, alternatively, benzenic, R represents a hydrogen atom or a lower alkyl group having from 1 to 4 carbon atoms, R' represents a linear alkyl radical having from 1 to 6 carbon atoms or a mono- or di-cycloalkyl-alkyl radical having from 4 to 7 carbon atoms, in their racemic form or in the form of optical isomers, and the salts thereof obtained with a therapeutically compatible mineral or organic base or the addition salts thereof obtained with a pharmaceutically compatible mineral or organic acid, characterised in that a carboxyisoindole derivative of the formula :  see diagramm : EP0129461,P8,F1  in which A has the same meaning as in formula I and R" represents an alkyl group having from 1 to 6 carbon atoms, preferably a tert.-butyl group, or one of the addition salts thereof, is condensed with a functional derivative of a substituted amino acid of the formula III :  see diagramm : EP0129461,P8,F2  in which R et R' have the same meanings as in formula I and the nitrogen atom is protected by a radical customarily used for protection in the synthesis of peptides, such as benzyloxycarbonyl or tert.-butoxycarbonyl, and the intermediate compound obtained is subjected to customary deprotecting processes, such as, for example, total or partial saponification, and/or hydrogenolysis, and in this manner is converted into a compound of the formula I.
Patent NZ-215839-A (NZ)
Title: Process for the preparation of ozone in an ozonisation loop followed by adsorption of the ozone and desorption by counter current gas flow
Inventor: GRENIER M
IPC: C01B13/10
Filed: 1986-04-15
Abstract: Each ozonization loop (1) which includes a compressor (2), an ozonizer (3), and a heat exchanger (8) for cooling the oxygen-ozone mixture, is associated with three cylinders (4,5,6) filled with silica gel. Each cylinder operates in succession in a cocurrent adsorption, in countercurrent desorption by a substitution gas, and in scavenging by taking off a part of the flow circulating in the loop. The scavenging flow is recovered and combined with the substitution gas. The substitution gas may be in particular impure nitrogen supplied by an air distillation apparatus producing the necessary oxygen.
Patent NZ-221938-A (NZ)
Title: Hybridomas and monoclonal paratopic molecules to apoliproprotein a-i
Inventor: CURTISS LINDA K
IPC: C12P21/08
Filed: 1987-09-25
Abstract: Hybridomas and their secreted paratopic molecules that immunoreact with apolipoprotein A-I are disclosed, as are assay methods for determining the presence and amount of apo A-I, and diagnostic systems useful in performing those determinations. Monoclonal paratopic molecules secreted by hybridomas having ATCC accession numbers HB 9200, HB 9201, HB 9202, HB 9203 and HB 9204 are utilized.
Patent NZ-226347-A (NZ)
Title: Determining contact position of surfaces of disc refiner
Inventor: AKERBLOM B
IPC: B02C/
Filed: 1988-09-27
Abstract: PCT No. PCT/SE88/00459 Sec. 371 Date Feb. 6, 1990 Sec. 102(e) Date Feb. 6, 1990 PCT Filed Sep. 8, 1988 PCT Pub. No. WO89/02783 PCT Pub. Date Apr. 6, 1989.Methods for determining the contact position between a pair of relatively rotating refining surfaces are disclosed including detecting the heat radiating from the initial contact between the pair of refining surfaces during relative rotation therebetween in order to generate an output signal and utilizing the output signal to determine the contact position. Apparatus for determining the contact position is also disclosed.
Patent NZ-229832-A (NZ)
Title: Condensed heterocyclic compounds, preparation and pharmaceutical compositions thereof
Inventor: KLAUS MICHAEL
IPC: C07D319/18
Filed: 1989-07-05
Abstract: Compounds of the formula 
<IMAGE>
 in which the symbols R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, n, X and Y have the meaning indicated in the description, can be used as medicines for oncological and dermatological indications.
Patent NZ-233222-A (NZ)
Title: Pyridine derivates and pharmaceutical compositions
Inventor: CLIFFE IAN ANTHONY
IPC: A61K31/473
Filed: 1990-04-05
Abstract: Pyridine derivatives of formula <CHEM> their heteroaromatic N-oxides and their pharmaceutically acceptable acid addition salts are disclosed. In the formula z is 0,1 and 2 and R,R<1>,R<2> and R<2> have specified meanings. The compounds exhibit activity as 5-HT1A agonists, antagonists or partial agonists and are useful for the treatment of CNS disorders eg anxiety, as antihypertensives and in treating anorexia.
Patent NZ-234636-A (NZ)
Title: Nitrofurantoin particulates
Inventor: CAZER FREDERICK DANA
IPC: C07D405/12
Filed: 1990-07-24
Abstract: Nitrofurantoin particulates comprising discrete particulates of nitrofurantoin wherein:     (a) said particulates are larger than about 200 mesh size; and (b) the BET surface area of said particulates is at least about 0.2 M<2>/g. Preferably, the surface of said particulates consists essentially of nitrofurantoin monohydrate. Also preferably, said particulates comprise at least about 5%, more preferably at least about 50% of nitrofurantoin monohydrate. Preferred compositions of this invention comprise these nitrofurantoin particulates in an aqueous suspension. The nitrofurantoin particulates of this invention are highly efficacious for the delivery of nitrofurantoin in oral dosage forms.
Patent NZ-236255-A (NZ)
Title: Pharmaceutical preparations containing 1,3bis(triazol-1-yl-2-phenyl propane derivatives and polyethylene glycol
Inventor: FRIES WALTER
IPC: A61P31/04
Filed: 1990-11-28
Abstract: A pharmaceutical preparation for parenteral administration of a drug consisting of a solvent system containing:   (a) 0 to 65% by weight of  alpha -tetrahydrofurfuryl- omega -hydroxy-polyloxyethylene; (b) 10 to 100% by weight polyethylene glycol with a mean molecular weight of 200 to 600; and   (c) 0 to 35% by weight of water   The sum of components (a) and (b) amounting to at least 65% by weight, and one or more therapeutically active compounds of the formula <CHEM> wherein R1 denotes a phenyl radical optionally substituted with 1 to 3 substituents independently selected from the group consisting of F, Cl, Br, I, CF3, C1 to C4 alkyl, and C1 to C4, alkoxy, or 5-chloro-pyrid-2-yl; X denotes OH, F, Cl or Br; R2 is H, CH3 or F; and R3 is H or F.
Patent NZ-237892-A (NZ)
Title: Carrier stock for grouping identical containers; integral handle for carrying assembled package
Inventor: MARCO LESLIE STEPHEN
IPC: B65D67/02
Filed: 1991-04-19
Abstract: Carrier stock (10) formed from a single sheet of resilient polymeric material, such as low density polyethylene, and severable into individual carriers (20) with integral handles (50). For each carrier (20), integrally joined band segments (22,24,26,28,32,34,36,38,40) define container-receiving apertures (14). Moreover, an integral handle (80) is joined at its ends (52) respectively to middle portions of two outer segments (22), which are joined to one cross segment (34) at a node (44). Stresses are distributed from each end (52) of the handle (80), through the outer segments (22) to two cross segments (32,34). Perforated lines (60) divide alternate cross segments (32) into half segments (62) and facilitate severance of such stock (10) to form the individual carriers (20). Each half segment (62) preferably has an aperture-defining edge configured to provide means, which may comprise a nub (70), for countering tendencies of such half segment (62) to neck down or to break when stressed. The handle (50) preferably has a middle leg (54), which is joined to the node (44) via a frangible joint (58), such as a perforated line (56) extending across the middle leg (54). The frangible joint is designed to break away when stressed to provide a hole to accommodate a users hand. <IMAGE>
Patent NZ-239081-A (NZ)
Title: Impact-resistant film comprising two outer layers of high melt flow
Inventor: MUELLER WALTER BERNDT
IPC: B32B27/28
Filed: 1991-07-23
Abstract: An impact resistant film suitable for making medical solution pouches generally includes an interior layer of a polyolefin such as an ethylene vinyl acetate copolymer, ethylene methyl acrylate copolymer, very low density polyethylene or blends thereof; and outer layers of a high melt flow propylene homopolymer or copolymer. At least one of the outer layers also includes an elastomer such as a styrene ethylene butylene styrene copolymer. A flexible copolyester can be substituted for one of the outer high melt flow polymer layers. Additional interior layers can also be incorporated in the film structure.
Patent NZ-242880-A (NZ)
Title: Substituted 3-aminoquinuclidines and pharmaceutical compositions
Inventor: ITO FUMITAKA
IPC: A61K31/445
Filed: 1992-05-22
Abstract: Compounds of formula (I), wherein W, Ar<1>, Ar<2> and Ar<3> are defined as below; and the pharmaceutically acceptable salts of such compounds. These compounds are substance P antagonists and useful in the treatment of gastrointestinal disorders, inflammatory disorders, central nervous system disorders and pain.
Patent NZ-271928-A (NZ)
Title: Recombinant dna molecule useful for producing a heterologous protein
Inventor: SCOTT RICHARD W
IPC: C07K19/00
Filed: 1994-08-24
Abstract: The invention generally features a novel recombinant DNA molecule useful for producing a heterologous protein, e.g., insulin-like growth factor-I, in yeast. The DNA molecule includes the following sequences joined in frame and in the following 5' to 3' progression: a sequence encoding a signal peptide of a yeast secreted protein; a sequence encoding at least 5 amino acids of the N-terminal region of a mature acid phosphatase protein, a sequence encoding a heterologous protein. Preferably the DNA molecule also encodes a spacer element that includes a proteolytic cleavage site.
Patent NZ-280616-A (NZ)
Title: Antisense oligonucleotide derivatives with antiviral activity
Inventor: FURUKAWA HIDEHIKO
IPC: A61P31/12
Filed: 1994-01-31
Abstract: Compounds for the treatment or prophylaxis of a viral infection in a mammal, which may be human, are provided. The compounds are oligodeoxyribonucleic acid derivatives, and a novel route to such compounds is also provided together with intermediates of more general utility. The active compounds are of the general formula (1): <CHEM> wherein R1, R2 and R3 are hydrogen atoms, alkyl groups, aryl groups as defined, and anthraquinonyl groups as defined; Z is carbon or silicon; or R2, R3 and Z together represent fluorenyl or xanthenyl; R4 is a hydrogen atom, an alkyl group as defined, an aryl group as defined; Y1, Y3 and Y4 are oxygen, sulfur or >NH; Y2 is oxygen, sulfur, >NH, alkylene or phenylene; X is alkylene group as defined; m and n are 0 to 10; and B is an oligodeoxyribonucleotide of chain length 3 to 9; or salts thereof.