baber/WOPTO huggingface dataset:
Patent PT-2260101-E (PT)
Title: Microrna (mirna) mir-21 for diagnostic and therapeutic purposes
Inventor: THUM THOMAS
IPC: A61K31/7088
Filed: 2009-02-26
Abstract: The present invention relates to a promoter region of a microRNA, the use of a microRNA, in particular miR-21, and related elements for the diagnosis and for the manufacture of a medicament for the treatment and/or prevention of fibrosis and/or fibrosis related diseases. Additionally, the invention concerns antisense oligonucleotides against targets of miR-21. A cell deficient for miR-21, the promoter region and targets of miR-21 and a knock-out organism thereof are also encompassed. Finally, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases.
Patent PT-2262757-E (PT)
Title: Method for the production of 6-dimethyl amino methyl-phenyl-cyclohexane-1,3-diols
Inventor: OSWALD ZIMMER DR
IPC: C07C213/00
Filed: 2009-02-27
Abstract: A process for producing 6-dimethylaminomethyl-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-1,3-diols from 6-dimethylaminomethyl-1-hydroxy-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-3-ones by catalytic hydrogenation in the presence of heterogeneous or homogeneous catalysts, or by using metal hydrides.
Patent PT-760664-E (PT)
Inventor: PFLEIDERER WOLFGANG
IPC: A61K31/519
Filed: 1995-05-06
Abstract: PCT No. PCT/EP95/01731 Sec. 371 Date Feb. 18, 1997 Sec. 102(e) Date Feb. 18, 1997 PCT Filed May 6, 1995 PCT Pub. No. WO95/31987 PCT Pub. Date Nov. 30, 1995The present invention relates to the use of pteridine derivatives of the formula I in which X is O, NH or N-(C1-C5)-alkanoyl, R3 is the radical -OR4, -NR5R6 or -S(O)mR7, and R, R1, R2, R4, R5, R6, R7 and m have the meanings given in claim 1, which are nitric oxide synthase inhibitors, for the treatment of diseases which are caused by an increased nitric oxide level.
Patent PT-787135-E (PT)
Inventor: IMBERT THIERRY
IPC: A61P35/00
Filed: 1995-10-20
Abstract: PCT No. PCT/FR95/01388 Sec. 371 Date Apr. 21, 1997 Sec. 102(e) Date Apr. 21, 1997 PCT Filed Oct. 20, 1995 PCT Pub. No. WO96/12727 PCT Pub. Date May 2, 1996Water-soluble derivatives of epipodophyllotoxin, process for their preparation and their use for the treatment of rheumatoid arthritis, complaints caused by human papilloma virus and cancer.
Patent PT-920470-E (PT)
Inventor: HAUSMANN HEINZ
IPC: C08J7/04
Filed: 1997-08-07
Abstract: PCT No. PCT/EP97/04301 Sec. 371 Date Feb. 12, 1999 Sec. 102(e) Date Feb. 12, 1999 PCT Filed Aug. 7, 1997 PCT Pub. No. WO98/07774 PCT Pub. Date Feb. 26, 1998A multilayer flat molding with a visible side and a supporting layer, for example bathtubs or shower fittings, is described, the visible side consisting of a polyurethane surface coating layer and the supporting layer consisting of a reinforced polyurethane layer.
Patent PT-938417-E (PT)
Inventor: CHORLEY BRIAN
IPC: B42D15/10
Filed: 1997-09-19
Abstract: PCT No. PCT/GB97/02563 Sec. 371 Date Jul. 1, 1999 Sec. 102(e) Date Jul. 1, 1999 PCT Filed Sep. 19, 1997 PCT Pub. No. WO98/19866 PCT Pub. Date May 14, 1998A method of manufacturing a composite security thread, e.g. for a bank note, is produced by coating aluminium film onto a polyester film and coating selected regions with magnetic material. Photoresist characters are next printed onto the magnetic material, and a chemical applied to remove the aluminium coating except where protected by the resist. An obscuring silver coating is then applied over the magnetic material, and a final transparent material applied as a barrier to reduce the risk of damage during subsequent processing.
Patent PT-956807-E (PT)
Title: Discharging means for liquid contained in a cleaning bucket
IPC: A47L13/58
Filed: 1999-04-23
Abstract: Liquid discharge system comprises an opening (2) which is sealed by a wall formed by a rotating flap (5) that is applied against the opening. The flap is held pressed against the opening by a flange (10) which is applied underneath the flap free end. Hydraulic sealing is obtained by a seal (9) applied on the flap acting on the edge of the opening. Liquid is discharged from the opening by uncoupling the flange from the flap, and turning flap away from the opening.
Patent PT-1045815-E (PT)
Inventor: LOBMANN PEER
IPC: C01G23/053
Filed: 1999-08-30
Abstract: A sol-gel process for the production of titanium oxide layers which comprises the following stages:(i) preparation of a soluble, titanium-containing powder by:(a) reaction of a titanium alcoholate of the general formula Ti(OR)4, in which the radicals R are identical or different and represent straight-chain, branched or cyclic alkyl or alkenyl radicals having 1 to 10 carbon atoms, which optionally have one or more carbonyl and/or ester and/or carboxyl functions, with one or more polar compounds with completing, chelating properties,(b) heating of the solution,(c) adding of water to the solution, optionally in the presence of a catalyst,(d) concentrating of the solution until a powder is obtained,(ii) dissolving of the powder to form a sol,(iii) coating of a substrate with the sol and(iv) heating of the coated substrate, described.
Patent PT-1139793-E (PT)
Title: Inhibitors of the bitter taste response
Inventor: MARGOLSKEE ROBERT F
IPC: A23L27/23
Filed: 1999-12-22
Abstract: The present invention relates to methods for identifying inhibitors of the bitter taste response, and by methods of using such inhibitors to either block the perception of bitterness and/or promote the perception of a sweet taste. The inhibitors of the invention may be used as flavor enhancers in foods and pharmaceuticals. The methods of the invention may further be used to characterize the gustatory perception of novel tastants.
Patent SG-63787-G (SG)
Title: Pressure sensitive hot melt adhesive for sanitary products
IPC: C08L53/00
Filed: 1987-08-07
Abstract: A hot melt pressure-sensitive adhesive is provided which is selected to exhibit critical rheological properties which manifest themselves into the desired performance criteria of tenacious bonding and clean release.
Patent SG-129392-G (SG)
Title: Excavating device for digging trenches into the ground
IPC: E02F5/08
Filed: 1992-12-19
Abstract: A milling engine for cutting trenches in ground or soil provided with at least one vertical support plate on both sides of which milling drums are supported for rotation about an axis perpendicular to said plate. One or more movable fingers are mounted on the lower edge of the plate for oscillating movement aobut the central axis of the plate during the rotation of the drums to remove a web of soil beneath the plate. Oscillation of the fingers is effected through camming surfaces formed on opposing inner ends of the drums which camming surfaces cooperate with a cam disposed at the inner ends of said movable fingers.
Patent IE-38686-L (IE)
Title: 3-hydrazonomethyl rifamycin
IPC: C07D231/00
Filed: 1973-01-18
Abstract: 3-Hydrazonomethyl rifamycin compounds of the following formula and their 25-desacetyl and 16, 17; 18, 19; 28, 29-hexahydro derivatives:
[US3862934A]
Patent IE-850253-L (IE)
Title: Substituted hexahydro arylquinolizine
IPC: C07D491/22
Filed: 1985-02-01
Abstract: Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective  alpha 2-adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, antidiabetics, and platelet aggregation inhibitors.
Patent IE-41134-L (IE)
Title: Preparation of 7-amino-ceph-3-em derivatives
IPC: C07D501/18
Filed: 1975-02-27
Abstract: 7-Amino- DELTA <3>-cephem derivatives of the following formula <IMAGE> are prepared, in which the substituents are as defined in Claim 1. The said cephem derivatives are obtained by bringing an appropriately substituted acetamidodesacetoxycephalosporanic acid or a derivative thereof into contact with penicillin acylase. This is covalently bonded to a water-soluble support and can additionally be present in a form enclosed in a water-insoluble support material. The process product can be used as an intermediate for the synthesis of antimicrobial substances.
[GB1454975A]
Patent IE-840487-L (IE)
Title: Antineoplastic active compositions
IPC: A61P35/00
Filed: 1984-03-01
Abstract: Pharmaceutical compositions endowed with antineoplastic activities, containing bivalent negative selenium, for instance as diselenide; carboxylic acids, aldehydes or ketones having odd number of carbon atoms, and optionally poly alcohols, alcohols, aminoalcohols, corticosteroids, nicotinic acid, aminobenzoic acids.
[US4681753A]
Patent IE-780682-L (IE)
Title: Coin dispensing machine
IPC: G07D1/00
Filed: 1978-04-06
Abstract: A coin agitating attachment for use on rotary coin transport discs fed by a coin hopper for coin-dispensing and counting machines. The attachment can be made in several configurations of elastomeric materials each characterized by at least a superficial resiliency of limited stiffness such that any point of impact with or by a coin presents a yieldable contact surface which is nevertheless sufficiently rigid to repel and drive the coins while retaining the original shape or configuration.
[US4148331A]
Patent IE-36482-L (IE)
Title: Bicycloalkane derivatives
IPC: C07C45/00
Filed: 1972-06-07
Abstract: 1396561 Bicycloalkane ketones SCHERING AG 12 June 1972 [11 June 1971] 27259/72 Heading C2C Novel compounds of the formula including their optical antipodes and racemates (wherein R 1 , R 2 and R 3 are each C 1-4 alkyl and n is 1 or 2) are prepared by ketalization of the corresponding triones with an appropriate alkanol R 3 OH, preferably in the presence of an acidic catalyst. The starting materials are prepared as follows Conversion of the chloro compounds to the triones is effected with concentrated H 2 SO 4 . The novel compounds have use in the preparation of cycloalkabenzopyran derivatives (see Specification 1,396,562).
[GB1396561A]
Patent IE-43369-L (IE)
Title: Ships hull.
IPC: B63B1/04
Filed: 1976-04-30
Abstract: A displacement ship for the transport selectively of low and high density cargo includes a hull having a trapezoidal cross-section and extending between the stem and stern of the ship. The sides of the hull form an angle of from 35 DEG to 55 DEG with the horizontal and extend upwardly above the design water line of the ship a distance at least equal to one-fourth the height of the hull. The upper extremities of the side walls of the hull terminate at the main deck of the ship which is coextensive lengthwise with the hull. At least one additional deck adapted to store low-density cargo thereon and coextensive in length and width with the main deck is positioned thereabove.
[SE7505103A]
Patent FI-811437-L (FI)
Inventor: WEHINGER EGBERT
IPC: C07D211/90
Filed: 1981-05-11
Abstract: 1. Compound of the general formula I  see diagramm : EP0039863,P18,F1 in which R represents a phenyl radical which optionally contains 1 or 2 identical or different substituents from the group comprising nitro, chlorine, cyano or trifluoromethyl, with the exception of a phenyl radical which is at the same time ortho- and metadichlorosubstituted, when R**2 denotes methyl and R**4 denotes alkyl with 2-3 carbon atoms, R**1 represents a saturated hydrocarbon radical with up to 6 carbon atons which is optionally interrupted by an oxygen atom, R**2 and R**4 are always different and each represents hydrogen, alkyl with 1 to 4 carbon atoms or cyclohexylmethyl, with the exception of the compound diethyl-2-methyl-6-propyl-4-(3-nitrophenyl)-1,4- dihydropyridine-3,5-carboxylate.
Patent FI-812452-L (FI)
Inventor: SEIPP ULRICH
IPC: C07D307/77
Filed: 1981-08-07
Abstract: Disclosed are new heterocyclic compounds, medicaments containing them (for oral or parenteral administration) and processes for the preparation and use of these heterocyclic compounds and medicaments. The new compounds which particularly act as inhibitors of blood platelet aggregation and as blood pressure lowering agents correspond to the general formula    <IMAGE>  (I)  wherein R1 is hydrogen, a cation or the residue of an alcohol, R2 represents hydrogen or methyl, A is a member of the group consisting of the radicals -CH2-CH2-, (trans)-CH=CH- and -C 3BOND C-, and wherein B represents an alkyl or a cycloalkyl radical. In these compounds the phenyl radical may be arranged with respect to the double bond in the E- and/or in the Z-configuration and at the carbon atom bearing the group R2 (and others) may exist RS- or S-configuration. The compounds of formula I are prepared in a manner known per se starting from derivatives of 3 alpha ,5 alpha -dihydroxycyclopentane-1 alpha -acetaldehyde  gamma -lactol substituted accordingly and phosphonium salts of the formula   <IMAGE>  wherein R6 represents hydrogen or alkyl and wherein Hal is chlorine, bromine or iodine.
Patent FI-831604-L (FI)
Inventor: MEGURO KANJI
IPC: C07D401/04
Filed: 1983-05-09
Abstract: Dihydropyridine derivatives and acid addition salts thereof which are of use as prophylactic or/and therapeutic drugs for cardiovascular diseases, said dihydropyridine derivatives having the formula <IMAGE>  wherein R1, R2 and R3 are the same or different and each is alkyl, cycloalkyl, cycloalkylalkyl or alkoxyalkyl; R4 and R5 are the same or different and each is hydrogen, halogen, nitro, trifluoromethyl, alkyl, cycloalkyl, alkoxy, cyano, alkoxycarbonyl or alkylthio; R6 is hydrogen, alkyl, cycloalkyl, aralkyl, aryl or a pyridyl; X is oxygen, sulfur, vinylene, azomethine or a group of the formula  <IMAGE>  A is alkylene; Ar is aryl or a pyridyl; m is an integer of 1 to 3; n is an integer of 0 to 2.
Patent FI-844052-L (FI)
Inventor: WUETHRICH ALFRED
IPC: G08B29/00
Filed: 1984-10-15
Abstract: In the apparatus for signalling an alarm, for example, in a gas or fire detecting installation, a detector is reset after a first response and the time duration until the next-following detector response is determined and classified with respect to three classes of time periods. When the time duration until the further detector response is beyond a predetermined upper or outer time limit, no alarm signal is released and the apparatus returns into its original state. When the further detector response occurs between two time limits, the alarm is immediately signalled. When the further detector response occurs prior to a lower one of the two time limits, there is carried out still one further test during which the detector is once again reset. The alarm signal will only be released if an additional further detector response is still observed prior to the upper time limit. In this manner the reliability of alarm signalling can be enhanced and the frequency of the occurrence of false alarms, particularly due to the occurrence of short-time or brief spurious conditions, can be significantly reduced.
Patent FI-852547-L (FI)
Inventor: TOOLE JOHN J JR
IPC: C12R1/865
Filed: 1985-06-27
Abstract: The invention relates to recombinant DNA preparations which code for the cell production of human and porcine factor VIII:C, and the method for obtaining such DNA and for the expression thereof in bacterial and eukaryotic cells. The invention also relates to new compounds, including deoxyribonucleotides and ribonucleotides, which are used for obtaining clones which express factor VIII:C.
Patent FI-853642-L (FI)
Inventor: HAAS PETER
IPC: C08G18/18
Filed: 1985-09-23
Abstract: Composite polyisocyanate addition products are formed from (1) the reaction product of a compound having at least two isocyanate-reactive hydrogen atoms and a molecular weight of from 400 to 10,000, a polyisocyanate and a catalyst which is a diffusion stable amino alkyl urea having tertiary amino groups and corresponds to the formula   <IMAGE>   in which R1, R2, R3, R4, R5, R6, R7 and n each represent specified groups or values and (2) another different material such as polyvinyl chloride, ABS, lacquers and textiles. Known additives such as blowing agents, chain extenders and foam stabilizers may optionally be used in the production of reaction product (1). The composite materials of the present invention which are particularly useful in the production of bedding and seating furniture, seats used in transport means, dashboard panels, arm-rests and for other similar applications are characterized by their lack of discoloration due to the diffusion of the catalyst employed in producing reaction product (1).
Patent IE-34484-L (IE)
Title: Polyesters containing tertiary nitrogen atoms
IPC: C08F299/00
Filed: 1970-08-21
Abstract: 1276232 Polyesters; unsaturated polyester curing accelerators FARBENFABRIKEN BAYER AG 26 Aug 1970 [29 Aug 1969] 41081/70 Headings C3P and C3R Polyesters of the formula in which R 1 is a methyl or ethyl group, R 2 is an alkyl group with 1 to 6 carbon atoms, R 3 is a saturated alkylene group with 4 to 12 carbon atoms or a saturated cyclo-alkylene group or an arylene group, of which the dicarboxylic acids do not form cyclic anhydrides, and n is an integer from 1 to 100, are prepared by polycondensing a dicarboxylic acid of the formula with an excess of a tertiary amine of the formula by heating under an inert gas. Specified amines are N-bis-(#-hydroxypropyl)-p-toluidine and ptert-butyl amiline and N-bis-/#-hydroxybutyl)- p-ethylaniline, specified dicarboxylic acids are adipic, pimelic, sebacic, cyclohexane-1,4- cyclohexane-1,2-trans, isophthalic and terephthalic. The above polyesters may be used as curing accelerators in a curable resin composition comprising an unsaturated polyester, derived from phthalic anhydride, maleic anhydride and 1,2- propylene glycol, and styrene.
[GB1276232A]
Patent IE-34616-L (IE)
Title: Liquid hydrocarbon fuel
IPC: C10L1/195
Filed: 1970-10-02
Abstract: 1285197 Liquid hydrocarbon fuels IMPERIAL CHEMICAL INDUSTRIES Ltd 2 Oct 1970 [10 Oct 1969] 49834/69 Heading C5G The tendency of hydrocarbon fuels of flash point at least 90‹ F. and suitable for aircraft gas turbines to particulate dissemination on shock is reduced by the presence, in solution in the fuel, of polymer of viscosity average molecular weight greater than 10<SP>6</SP> or of intrinsic viscosity greater than 2À5 dls./gm in a concentration such that there is molecular overlap of the polymer molecules in the liquid; the polymer containing polar groups which form inter-molecular associative bonds arising from electrostatic attraction between polar and/or dipolar charges in the polar groups and the energy of the bonds being at least that corresponding to the energy of hydrogen bonds formed in the liquid hydrocarbon fuel between -OH groups of ROH reacting with -O- groups of ROR<SP>1</SP> (where R and R<SP>1</SP> are alkyl) but less than that of a typical C-C co-valent bond. Suitable polymers are free radical addition or condensation polymers and contain at least 10 polar groups per molecule of polymer and are used in an amount to provide 10<SP>-7</SP>-10<SP>-4</SP> gm moles of polar groups per gram of fuel. In the examples the polymers used are copolymers of 2-ethyl hexyl acrylate with acrylic acid, acrylonitrile or hydroxyethyl methacrylate; of C 12-14 alkyl methacrylate, vinyl octoate or vinyl isobutylene ether with acrylic acid; polystyrene of molecular weight 2 x 10<SP>6</SP> alkylated with octene-1 and then treated with oleum to introduce sulphonic acid groups into the polymer and which can be converted to the sodium salt by treatment with sodium methoxide; copolymer of 2-ethyl hexyl acrylate with vinyl pyridine which can be used together with acid-containing polymer solutions or heated with propane sultone, #-propiolactone, or benzyl chloride; copolymer of 2-ethyl hexyl acrylate and vinyl chlor-acetate which can be heated with triethylamine; or copolymer of 2-ethyl hexyl acrylate and glycidyl acrylate which is reacted with sulphuric or phosphoric acid, and then with calcium octoates to produce the calcium salt.
[GB1285197A]
Patent IE-791378-L (IE)
Title: Alpha-difluoromethyl amino acids
IPC: C07C67/00
Filed: 1979-08-08
Abstract: Novel  alpha -difluoromethyl tyrosines and esters thereof are disclosed. The novel compounds have useful pharmacological activity.
Patent IE-41198-L (IE)
Title: Digital/analog subterminal
IPC: H04J3/12
Filed: 1974-06-28
Abstract: 1469872 Pulse-code-modulation terminals NORTHERN TELECOM Ltd 28 June 1974 [29 June 1973] 28850/74 Heading H3H In a terminal for one channel in a pulse-codemodulation transmission system for transmitting a pulse train of recurrent frames divided into a plurality of channels, the clock pulses required for analogue-to-digital and/or digital-toanalogue conversion at the terminal are derived from the frame and digit synchronization pulses from the incoming digital signals. A counter 32 counts the recovered clock pulses and is reset to zero at the beginning of each frame. If there are more quantizing steps than total number of digits per frame a frequency multiplier could be driven by the recovered clock pulses or two or more coders could be provided operating in succession on a single channel. Analogue-to-digital conversion.-The analogue signal 70 is sampled by capacitor 73 the voltage on which then decays exponentially and is compared at 82 with an exponentially increasing voltage on capacitor 76 of polarity determined by detector 83 which also controls the polarity bit of the digital output signal. The count in counter 32 is transferred to register 86 when the comparator 82 switches over. The polarity bit is added at 87 and the digital output signal is gated out on the channel selected at 33 via AND gate 88 and OR gate 16. Digital-to-analogue conversion.-The incoming digital signal is converted to parallel form at 40 and a capacitor 51 charged to a positive or negative voltage in dependence on the polarity bit. The charge then decays exponentially during the time taken for the output of counter 32 to equal the amplitude bits, held at 43. Switch 57 is then opened and the output of amplifier 50 gated out through audio filter 58.
Patent IE-39583-L (IE)
Title: Halogenated 4-trifluoromethyl-4'-cyano-diphenyl-ethers;¹herbicides
IPC: A01N31/16
Filed: 1974-07-02
Abstract: Halogenated 4-trifluoromethyl-4'-cyano-diphenyl-ether compounds of the formula IN WHICH R is hydrogen, halogen, alkyl of from 1 to 4 carbon atoms, alkoxy of from 1 to 4 carbon atoms or alkylthio of from 1 to 4 carbon atoms, ARE OUTSTANDINGLY EFFECTIVE AS HERBICIDES, PARTICULARLY AS SELECTIVE HERBICIDES.
[US3954829A]
Patent IE-821512-L (IE)
Title: Increating the rate of animal growth
IPC: A23K20/195
Filed: 1982-06-24
Abstract: The growth and feed efficiency of food producing domestic mammals (especially ruminants) is improved by administering, a growth- promoting amount of the antibiotic lysocellin or a physiologically acceptable salt or metal complex thereof. Preferred metal complexes or salts of lysocellin are the sodium zinc, copper, and manganese derivatives.
[GB2107585A]
Patent IE-891662-L (IE)
Title: Aryl and heteroaryl piperazinyl carboxamides
IPC: A61K31/495
Filed: 1989-05-23
Abstract: The invention discloses compounds of the formula (I) <CHEM> wherein R<1> is 1-adamantyl, 3-methyl-1-adamantyl, 3-noradamantyl, unsubstituted or substituted-2-indolyl, 3-indolyl, 2-benzofuranyl and 3-benzofuranyl wherein the substituents are selected from lower alkyl, lower alkoxy and halo; R<2> is unsubstituted or substituted phenyl, benzyl, pyridinyl, pyrimidinyl or pyrazinyl, wherein the substituents are selected from lower alkyl, lower alkoxy, trifluoromethyl and halo; R<3> is H or lower alkyl of 1 to 3 carbon atoms, n is the integer 0 or 1; m is an integer from 2 to 5, and the pharmaceutically acceptable salts thereof which possess central nervous system activity.