baber/WOPTO huggingface dataset:
Patent EP-0306496-A1 (EP)
Title: Lipopolysaccharides of reduced toxicity and the production thereof.
Inventor: MUNFORD ROBERT S
IPC: C12N/
Filed: 1987-05-27
Abstract: An acyloxyacyl hydrolase from the human promyelocyte cell line HL-60 has been found to specifically hydrolyze fatty acids from their ester linkages to hydroxy groups of 3-hydroxyfatty acids, the latter being bound in turn to LPS glycosaminyl residues. The hydrolyzed fatty acids may include dodecanoic acid, tetradecanoic acid and hexadecanoic acid. This enzyme showed a molecular weight by gel exclusion chromatography between about 50,000 Daltons and about 70,000 Daltons. Altered bacterial LPS substantially without fatty acids bound in ester linkage to hydroxy groups of 3-hydroxyfatty acids covalently linked to a glucosaminyl moiety of LPS lipid A are produced. Since the structure of the lipid A moiety is highly conserved, acyloxyacyl hydrolase may act on LPS of many different pathogenic bacteria (for example Salmonella, Escherichia, Hemophilus, and Neisseria). Such altered bacterial LPS, having toxicity reduced more than immunostimulatory activity, may be therapeutically useful: (1) as vaccines to prevent Gram-negative bacterial diseases by inducing antibodies to LPS 0-polysaccharide or R-core antigens, (2) as antidotes to treat or prevent Gram-negative bacterial sepsis ("septic shock"), or (3) as adjuvants to enhance formation of antibodies to other antigens. The acyloxyacyl hydrolase itself may be prophylactically or therapeutically useful to detoxify endogenous LPS in patients with Gram-negative bacterial diseases. The enzyme may also be used to remove toxic LPS from therapeutic injectants.
Patent EP-0316320-A1 (EP)
Inventor: WILSON PATRICIA ANN
IPC: A61K39/00
Filed: 1987-07-07
Abstract: On réduit les pertes ovulaires et embryonnaires et on augmente par conséquent la fécondité dans un troupeau de moutons ou un groupe d'autres animaux domestiques, en immunisant activement les animaux femelles du troupeau ou du groupe contre un ensemble de stéroides comprennant un seul stéroïde appartenant à chacune des classes d'androgènes et d'oestrogènes. Les immunisations s'effectuent avant une période d'accouplement qui dure au moins deux fois la durée du cycle oestrale moyen pour les espèces d'animaux concernés, de sorte que les niveaux d'anticorps atteint par les animaux femelles du troupeau contre les stéroïdes de l'ensemble sont suffisament élevés pour réduire les pertes ovulaires et embryonnaires et augmenter par conséquent la fécondité, sans pour autant être trop élevés de façon à éviter de réduire sensiblement la manifestation de comportements oestraux de la part des animaux femelles immunisés durant la période d'accouplement. L'immunisation est effectuée de tel sorte que les niveaux des anticorps contre les stéroïdes de l'ensemble concerné décroissent de préférence de 30 à 90% durant la période d'accouplement.
Patent EP-0333744-A1 (EP)
Title: Method and apparatus for manufacturing printed circuit boards.
Inventor: JOHNSTON JAMES A
IPC: B23B41/00
Filed: 1987-11-10
Abstract: A dual purpose separator-release plate (30) for the use in the lamination and drilling of printed circuit boards, comprising a substrate sheet of aluminum foil (32), covered on both sides with release material (34), the plates being placed in engagement with the foil surfaces (6 and 8) of a PC board prior to curing the epoxy layer (4), after curing, retaining the separator-release plates in engagement with the PC board, and which plates serve as drill entry and drill backup material.
Patent EP-0281841-A1 (EP)
Title: Verfahren zur Herstellung von 5-Amino-4,6-dihalogenpyridinen
Inventor: HALLENBACH WERNER DR
IPC: C07D213/73
Filed: 1988-02-24
Abstract: Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von 5-Amino-4,6-dihalogenpyridinderivaten der Formel I <IMAGE> in welcher R¹ für Wasserstoff, -O-R<7> oder -NHR<8> steht, R² für Wasserstoff, Halogen steht R³ für Wasserstoff, oder gemeinsam mit R² für =O steht, R<4> für Wasserstoff oder Alkyl steht, R<5> für Wasserstoff, Alkyl, Halogenalkyl, Aryl steht, R<7> für Alkyl, R<8> für Alkyl, Cycloalkyl, Aralkyl, Aryl, Heterocyclyl steht, die gegebenenfalls substituiert sein können, R<9> für Acyl oder Wasserstoff, Hal für Halogen steht, dadurch gekennzeichnet ist, daß man Verbindungen der Formel II <IMAGE> mit Halogenwasserstoffsäuren, in Gegenwart von Oxidationsmitteln halogeniert. Sie betrifft ferner die neuen 5-Aminopyridine der Formel III <IMAGE> und ihre Herstellung.
Patent EP-0294607-A1 (EP)
Inventor: THUNER UDO TH
IPC: B60P3/22
Filed: 1988-05-11
Abstract: In order, in a two chamber waste disposal container, in particular for waste disposal vehicles, having an axially displaceable ejecting piston which separates the suction chamber of the container, provided with a lid capable of being opened, from the pressure chamber, the ejecting piston being provided with at least one guide ring and seals, arranged between the outside of the guide ring and the inside of the container wall, and also a plate which blocks off the lumen of the guide ring, to make safe the functioning of the ejecting piston by automatic and mechanical safety devices, to monitor and control the impulses for the sliding movement of the ejecting piston, to counteract operating errors and to increase operating reliability and safety, and also in order to stop the ejecting piston, in the event of the failure of the upstream safety devices, at the container end, in which process the stopping is to cause no damage, repairable only at considerable expense, to the container and/or to the ejecting piston, the seals are designed as guide profile rings (13), of which one sealing profile ring (13) is situated at the end of the ejecting piston (10) assigned to the pressure chamber (3.2) and another sealing profile ring (13) is situated close to the end assigned to a suction chamber (3.1). <IMAGE>
Patent EP-0297333-A1 (EP)
Inventor: LANGEN MANFRED
IPC: B65G19/02
Filed: 1988-06-13
Abstract: Bobbins wound with textile yarns can be suspended pendulously in a row on a trolley line in a close sequence corresponding to the division of the spinning machine, without the danger, when the trolley line is deflected obliquely upwards or downwards from the horizontal, that the bobbins will be subjected to mutual friction, if the bobbins are fastened to the trolley line in pairs on a bridge rotatable about a vertical axis and, before the line enters an incline, the bridge is pivoted through 90 DEG  about the vertical bridge axis. <IMAGE>
Patent EP-0300390-A1 (EP)
Inventor: HERTEL HASSO DR
IPC: C07C217/78
Filed: 1988-07-16
Abstract: 1. The use of a compound of the general formula (1)  see diagramm : EP0300390,P11,F4  in which R is a straight-chain or branched alkyl group which has 2 to 8 carbon atoms and which can be substituted by an alkoxy group having 1 to 4 carbon atoms, and in which the alkoxy group R-O- is in the para-position and the amino group is in the meta-position relative to the trifluoromethyl group or in which the alkoxy group R-O- is in the meta-position relative to the trifluoromethyl group and the amino group is in the ortho-position relative to the trifluoromethyl group and in the para-position relative to the alkoxy group, as a diazo component (developing component) in azoic dyeing.
Patent EP-0321676-A1 (EP)
Inventor: GERSING EBERHARD DR
IPC: A61G5/04
Filed: 1988-10-24
Abstract: The electrically propelled vehicle, which in particular is designed as a three-wheeled scooter, has an angular position detector (11, 12, 13) on the steerable front wheel (5), which measures the position of a steering axle (9) relative to the chassis (1). The initial signal from the angular position detector (11) is linked to a drive unit (4), so that the driving speed is reduced as the steering angle increases. In this manner, the danger of tipping over is eliminated, even in the case of abrupt steering movements. <IMAGE>
Patent EP-0300537-A1 (EP)
Inventor: MUNNIG SCHMIDT ROBERT HAN
IPC: H02J7/00
Filed: 1988-07-04
Abstract: If when a load (R L ) is powered by a battery (6) first detection means (100) detect that the expired dis­charge time measured by measurement means (40, 70) is equal to the first reference value stored in a memory (22), first time measurement means (40, 80) measure the time during which the load (R L ) is powered by the battery (6). When the load (R L ) is switched off and is not connected to the mains voltage  via  a power-supply circuit (1), the battery (6) is discharged by a discharger (9). Second time-­measurement means (50, 80) measure the time during which this discharger (9) is operative until second detection means (13) detect a battery voltage for which the battery (6) may be regarded as fully discharged. After comparison of the sum of the time intervals measured by the first and the second time-measurement means with a second reference value stored in a memory (21), the correction means (10) correct the reference value stored in a memory (22) in such a way that during a next discharge the sum of the time intervals measured by the first and the second time-­measurement means is better in agreement with the second reference value.
Patent EP-0318065-A1 (EP)
Inventor: PEARCE HOWARD R
IPC: H01R43/042
Filed: 1985-08-07
Abstract: A bandolier assembly is provided for use in an apparatus for assemblying a two-part electrical connector with an interposed cable. The bandolier, which is elongate, supports a plurality of pre-assembled connectors (13) in longitudinally spaced envelopes (40) in preparation for crimping of the connector (13) and an interposed cable.
Patent EP-0279590-A1 (EP)
Inventor: KOHRING MARK D
IPC: B25J9/14
Filed: 1988-02-11
Abstract: A rotator bearing shock and vibration dampener for the rotator bearing of a robotic manipulator, with such shock dampener including a stationary robot base (12) and a rotary turntable (14), and a large rotary turntable bearing (20) having its inner race bolted to the stationary base and its outer race bolted to the rotary turntable. An oil damp well space (30, 31) having a relatively thin predetermined depth relative to its surface area is formed in the base (12) below the outer race and in the turntable (14) above the inner race. A predetermined volume of damping oil is located adjacent to the turntable bearing (20) in the base and fills the oil damp well space (30, 31), whereby the damping oil normally resides in the well space to provide an oil film therewithin. The well space is formed with relatively limited inlets and outlets for the damping oil such that the oil film tends to resist compression and displacement, thereby damping vibrations, mechanical shocks and jolts encountered by the robotic manipulator in use, and increasing the effective dynamic stiffness of the turntable (14) relative to the base (12).
Patent EP-0296748-A1 (EP)
Inventor: FOREMAN MARK MORTENSEN
IPC: C07D457/06
Filed: 1988-06-14
Abstract: This invention provides (8β)-N-cycloalkyl-1-­alkyl-6-(substituted)ergoline-8-carboxamides of the formula
      wherein: 
    R¹ is C₁-C₄ alkyl; 
    R² is allyl or C₁-C₄ straight chain alkyl; 
    R³ is hydrogen or C₁-C₄ straight chain alkyl; 
    R⁴ is hydrogen, C₁-C₄ alkyl, hydroxy or C₁-C₄ alkoxy; 
    m is 0, 1, 2 or 3; or 
    a pharmaceutically acceptable acid addition salt thereof. 
     The compounds are useful for blocking 5HT₂ receptors in mammals having an excess of serotonin centrally or peripherally.
Patent EP-0303348-A1 (EP)
Inventor: WALKER FREDERICK JUDSON
IPC: C07H17/08
Filed: 1988-07-01
Abstract: A compound of the formula
      or a pharmaceutically acceptable salt thereof, 
    wherein R¹ is hydrogen; R² is (C₁-C₁₅)alkyl, (C₃-C₁₅)alkenyl, phenyl, substituted phenyl, (C₇-C₂₀)­phenylalkyl, or substituted (C₇-C₂₀)phenylalkyl wherein the substituents on the substituted phenyl and sub­stituted phenylalkyl are independently one or two of fluoro, chloro, (C₁-C₃)alkyl, (C₁-C₃)alkoxy, and trifluoromethyl; or R¹ and R² together with the nitrogen atom to which they are attached form a pyrrolidinyl, substituted pyrrolidinyl, piperidyl or substituted piperidyl group, wherein the substituents on said substituted pyrrolidinyl and piperidyl groups are independently one of (C₁-C₆)alkyl, phenyl, and (C₇-C₉)phenylalkyl; and R³ is hydrogen, (C₁-C₆)alkyl, phenyl, substituted phenyl, (C₇-C₉) phenylalkyl, or substituted (C₇-C₉)phenylalkyl, wherein the substituents on the substituted phenyl and substituted phenylalkyl are independently one or two of fluoro, chloro, (C₁-C₃)alkyl, (C₁-C₃)alkoxy, and trifluoro­methyl. 
     The compounds are useful in treating inflammation or other leukotriene mediated diseases, including pulmonary, asthmatic, allergic, and gastrointestinal diseases.
Patent EP-0309304-A1 (EP)
Inventor: COMBETTE MARC
IPC: F15B15/28
Filed: 1988-08-30
Abstract: Electric and/or electronic sensor or detector for a movable element, of which the position in relation to a fixed element is to be detected. 
<??>It comprises a one-piece annular clamping collar 2 capable of being clamped in position on a casing 23, 24 and connected to at least one connecting conductor 10, the collar carrying at least one member 15 for mechanical and electrical connection to an interchangeable detector element 16. 
<??>The invention is used for position detectors comprising a supporting part of set position and an interchangeable sensor element. 
<IMAGE>
Patent EP-0307293-A1 (EP)
Inventor: LE GOFF JEAN-FRANCOIS
IPC: F16B1/00
Filed: 1988-09-02
Abstract: The present invention relates to a coupling system for two bodies (11, 12) capable of having relative movements with respect to each other of a given uncertainty of amplitude. 
<??>The system is essentially characterised in that it comprises, on a first body (11), a projecting part (13) having an end section (15) of a specified value, and means (16) for controlling the displacement of this projecting part with respect to the first body, on the second body (12), a cavity (17) having an entry orifice (18), the cross- section of which has dimensions greater than those of the end of the projecting part, the value of the difference between these two cross- sections being at least equal to that of the given uncertainty, and means (19) for exerting at least a pair of reaction forces between the projecting part (13) and the inner wall (20) of the cavity (17). 
<??>Application, in particular, to systems for coupling carriages and working stations in flexible manufacturing systems. 
<IMAGE>
Patent EP-0322383-A1 (EP)
Inventor: BIANCALANI MAURO
IPC: D06F75/14
Filed: 1988-12-22
Abstract: An iron comprising a one-piece moulded body (5) including a reservoir cavity (5A, 5C) which is open at the rear and is able to receive a fixed obturator (10); an additional cavity (5B) which is also open at the rear and defines the handle; a front funnel-shaped opening (5H) which communicates with the reservoir cavity (5A, 5C) in the top front part of the same; a bottom opening (7) closed by the cover part (3A) of a heat separator (3) which is disposed between the heating plate (1) and said body (5) and is further provided with a seat for a nozzle (12) to deliver water to the vaporization chamber (1A); and seats (5E, 5F) for pumping means, opposite said bottom opening (7), in the top part of said body (5).
Patent EP-0317647-A1 (EP)
Inventor: KITAGAWA TOSHIYUKI
IPC: A61B5/274
Filed: 1988-06-10
Abstract: This invention relates to a terminal electrode device for an electrocardiograph or an electroencephalograph, which can be used in a bath. The device comprises a disposable terminal electrode (A) and a connector (B) which can be attracted to the terminal electrode (A) by force of a permanent magnet. The terminal electrode (A) has a case (2) for accommodating an electrode (1a), an electrode base (1) and a sponge (5) associated with the electrode, a ring-like water- proof sheet (37) on the lower surface, and a sticking sheet (3) in the outer circumferential portion having air-permeability and water-permeability. The device is stuck to the human body by the sticking sheet (3) and the water-proof sheet (37) protects the electrode (1a) from water. The connector (B) has a connector body (13) containing a lead wire (11) that electrically couples to the electrode (1a) when attracted by the permanent magnet. Water-proof sealing members (7, 16) are provided in the contact portion between the connector member (13) and the case (2) of the terminal electrode (A), so that water will not infiltrate into the connector (B).
Patent EP-0328659-A1 (EP)
Inventor: SEKI MASAKI
IPC: G06T15/00
Filed: 1988-07-20
Abstract: In a three-dimensional presentation method of a structure, a rectangular parallelepiped (RP) having the sides (L x , L y , L z ) equal to the respective distances between the nearest and farthest positions of a structure (SML) along the three axes from the origin is constituted of a number of identical cubes (UC), and the structure is expressed by the data that indicate whether the unit cubes constitute the struc­ture (SML) or not. The individual unit cubes constituting the structure (SML) are successively drawn starting from the ones that are seen from the observer. The planes of unit cubes overlapped on the planes of the unit cubes that are drawn already are not drawn, and only those planes that are visually located near the observer are draw in to provide a perspective view of a three-dimensional structure (SML).
Patent EP-0342207-A1 (EP)
Inventor: FRANKEL ROBERT D
IPC: G03F7/20
Filed: 1988-08-23
Abstract: An improved target (18, 44, 56, 66, 76 or 102) for use in a laser pulse (12 or 104) induced plasma X-ray lithography 
system (10 or 100) has a plurality of small holes (74 or 90) fabricated through a base (68 or 84) against which the laser beam 
(121 or 104) is focused. A film (70 or 86) covers each hole (74 or 90) and a thin layer of metal target material (72 or 88) is 
placed on the film (70 or 86). The thickness of the metal material (72 or 88) is selected to be sufficient to allow the complete 
ablation of the material during the existence of the laser beam (12 or 104) inducing the X-ray emitting plasma (20). In this 
manner, a minimal amount of debris (30) will be generated. The angle of the plane of the target (18, 44, 76 or 102) relative 
to the mask (24 or 110) plane and the angle of incidence of the laser beam (12 or 104) relative to the normal line to the tar­
get (18, 44, 76 or 102) are selected so that both the X-ray mask (24 or 110) and the laser beam (12 or 104) optical elements 
(113) are positioned in an area where few, if any, molten droplets of debris (30) are emitted.
Patent EP-0325990-A1 (EP)
Inventor: WIEDEMANN WOLFGANG DR
IPC: G11B7/2492
Filed: 1989-01-17
Abstract: A multilayer recording material which can be recorded on once and is intended for optical information and its production process are described. The recording material essentially consists of a substrate and a layer of an unsubstituted naphthalocyanine dye and either carries a binder layer between these two layers or contains, over the dye, a binder layer which in turn has a dye layer. Laminate systems, in particular adhesively bonded laminates, composed of these multilayer recording materials are also described. …<??>The materials and laminates according to the invention have high reflectivity and a lower write signal energy while maintaining a certain contrast ratio than comparable materials of the prior art.
Patent EP-0329089-A1 (EP)
Inventor: FELIX WILLI
IPC: B41J13/08
Filed: 1989-02-14
Abstract: A feeding mechanism (26) removes with frictional engagement a printed or unprinted paper web (12) from a supply roll (10). Single sheets (14) are cut off the paper web (12) using a cutting device (28) and are fed by means of a conveying device (32) to the document feeder of a high-speed printer. A smoothing device (22) connected in front of the cutting device (28) cancels out curves in the paper web (12) as a result of their mounting on the supply roll (10) and smooths out possible unevenness in the paper web (12) by means of the smoothing rollers (40, 42). A perforating device (24) can be used to punch transmission holes into the paper web (12). The individual sheets (14) cut from the paper web (12) are placed by means of an acceleration device (30) to give an overlapping formation onto the conveying device (32). The large storage capacity of the supply roll (10) makes it possible for the high-speed printer to be supplied over lengthy periods with individual sheets (14) from a single supply roll (10) without interrupting the operation. <IMAGE>
Patent EP-0330907-A1 (EP)
Inventor: STADLER EDWIN DR
IPC: A23G3/32
Filed: 1989-02-15
Abstract: Nut croquant has up until now been produced in the batch process or the continuous process. Even the use of the already known continuous process does not guarantee the production of a product of uniform quality, as the potential for process control is limited. 
<??>The production of nut croquant in a screw extruder (13), the transport path (36) of which is subdivided into individual zones (37 to 44) which can be heated independently of each other, allows the presetting of temperature profiles for optimum process control. 
<IMAGE>
Patent EP-0331968-A1 (EP)
Inventor: GOERGEN RICHARD
IPC: B29B7/00
Filed: 1989-02-21
Abstract: The present invention relates to the continuous production of foamable and curable phenol resol resin mixtures in continuously operating mixers. According to the invention, the mixing is performed in injection mixers, in which an injector tube (2), provided with an injection spiral (1, 3), protrudes into a mixer tube (4). The mixer tube is provided with a mixing and conveying spiral, which mixes the material to be mixed in the form of a liquid ring on the wall of the tube and transports it to the outlet end of the mixer. The hardener (8) is introduced into that part of the mixer tube which is arranged behind the end of the injection tube in the direction of the outlet nozzle. The production according to the invention permits simultaneous mixing of all the ingredients of a filled phenol resin foam before curing of the foam, without premixing being necessary, and is also suitable for the production of highly filled foams with a solids content of up to 80% by weight. <IMAGE>
Patent EP-0331012-A1 (EP)
Inventor: RUTZ WERNER
IPC: E03F7/10
Filed: 1989-02-23
Abstract: The invention relates to a device for the suction removal and delivery of fine deposits from a raw water zone (3) into a sludge collection zone (4) of a sewer-cleaning apparatus, in particular in vacuum cesspool cleaners, comprising a cylindrical container (1) which is divided by a piston (2), axially displaceably therein, into the raw water zone (3) and the sludge collection zone (4) and which can be non-positively and, via a stop (10), positively fixed in the cylindrical container (1), a blockable pipeline (12) which is open on both sides and whose opening on the side of the raw water zone lies close to the container inner wall in the lower container part is situated between the raw water zone (3) and the sludge collection zone (4).
Patent EP-0334176-A1 (EP)
Inventor: GILLBERG-LAFORCE GUNILLA E
IPC: G02F1/361
Filed: 1989-03-14
Abstract: In one embodiment this invention provides a nonlinear optical medium which is a composite of a polymer matrix which exhibits nonlinear optic response, and a silver colloid which is dispersed in the polymer matrix.
Patent EP-0340497-A1 (EP)
Inventor: KASPER ERICH DR
IPC: H01L23/532
Filed: 1989-04-13
Abstract: The invention relates to a method of manufacturing monolithic integrated multifunctional circuits. A switching circuit is integrated in the substrate and other multilayer semiconductor devices and the associated electrical leads are arranged on the substrate one on top of the other. The multilayer semiconductor devices and the electrical leads are produced from an epitaxially grown semiconductor layer sequence.