Patent SG-11201905601V-A (SG)
Title: Scn9a antisense pain killer
Inventor: CHUNG SHIN
IPC: C12N15/113
Filed: 2018-01-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 August 2018 (02.08.2018) WI P0 I PCT omit VIII °nolo oil! iflo oimIE (10) International Publication Number WO 2018/138585 Al (51) International Patent Classification: C07K 14/00 (2006.01) C12N 15/113 (2010.01) (21) International Application Number: PCT/IB2018/000160 (22) International Filing Date: 23 January 2018 (23.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/449,738 24 January 2017 (24.01.2017) US (71) Applicant: OLIPASS CORPORATION [KR/KR]; 20th Floor, Ace Dongbaek Tower, 16 Beon-gil, 16-4 Dongbaek Jungang-ro, Giheung-gu, Yongin-si, Gyeonggi-do 17105 (KR). (72) Inventors: CHUNG, Shin; Apt. 103-3703, 527 Beon- gil 80, 527 Beon-gil 80, Dongbaek Jukjeondae-ro, Gi- heung-gu, Yongin-si, Gyeonggi-do 16990 (KR). JUNG, Daram; The Sharp Central-city 1406-1502, 19 Dongtan- daerosibeom-gil, Hwaseong-si, Gyeonggi-do (KR). CHO, Bongjun; 316-1102 Ssangyong Apt. 20, Jungbudae-ro, 788 Beon-gil, Giheung-gu, Yongin-si, Gyeonggi-do 17077 (KR). JANG, Kangwon; Apt. 1701-1702, Dongbaek8-ro 9, Giheung-gu, Yongin-si, Gyeonggi-do 16998 (KR). JEON, Hyun Ju; 105 Dong 1301 Ho, 62-28, Eojeong-ro, Gihe- ung-gu, Yongin-si, Gyeonggi-do (KR). BAE, Jinyoung; 3rd Floor 302, Pyeongchonl-ro 8beon-gil 5-19, Gihe- ung-gu, Yongin-si, Gyeonggi-do (KR). BAE, Taeyeon; 201 Ho, 31, Pyeongchon 3-ro, Giheung-gu, Yongin-si, Gyeonggi-do 17001 (KR). JEON, Yeasel; 506, Hou-star, 98-32, Dongbaekjukjeon-daero, 527 Beon-gil, Giheung-gu, Yongin-si, Gyeonggi-do (KR). LEE, Jun Yeon; Apt. #201-706, 33, Yeonwon-ro 42beon-gil, Giheung-gu, Yon- gin-si, Gyeonggi-do (KR). PARK, Sun Hwa; 717-701 SK View Apt. 27-7, Baegot 3-ro, Siheung-si, Gyeonggi-do (KR). AN, Dan Bi; Apt. # C-608, 283, Dongbaekjun- gang-ro, Giheung-gu, Yongin-si, Gyeonggi-do (KR). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — (54) Title: SCN9A ANTISENSE PAIN KILLER Figure lA HO OH Lidocaine Tetrodotoxin el (57) : The current invention provides peptide nucleic acid derivatives targeting the 3' splice site of exon 4 in the human SCN9A pre-mRNA. The peptide nucleic acid derivatives potently induce SCN9A mRNA splice variant(s) lacking the SCN9A exon 4 in cells, and are useful to safely treat pains or conditions involving Na v 1.7 activity.