Patent SG-11201811184U-A (SG)
Title: Lag -3 binding members
Inventor: TUNA MIHRIBAN
IPC: C07K16/28
Filed: 2017-06-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111011111111101 11111111111111111111111111111111101111111111H111111111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2017/220555 Al 28 December 2017 (28.12.2017) WIP0 I PCT (51) International Patent Classification: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, C07K 16/28 (2006.01) A61K 39/00 (2006.01) TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. A61P 35/00 (2006.01) (84) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of regional protection available): ARIPO (BW, GH, PCT/EP2017/065052 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (22) International Filing Date: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 20 June 2017 (20.06.2017) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (25) Filing Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (26) Publication Language: English TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (30) Priority Data: 62/352,470 20 June 2016 (20.06.2016) US Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) (71) Applicant: F-STAR BETA LIMITED [GB/GB]; Edde- va B920, Babraham Research Campus, Cambridge Cam- Published: bridgeshire CB22 3AT (GB). — with international search report (Art. 2 I (3)) (72) Inventors: TUNA, Mihriban; c/o F-star Biotechnology Limited, Eddeva B920, Babraham Research Campus, Cam- — bridge Cambridgeshire CB22 3AT (GB). WOLLERTON VAN HORCK, Francisca; c/o F-star Biotechnology Lim- ited, Eddeva B920, Babraham Research Campus, Cam- bridge Cambridgeshire CB22 3AT (GB). EVERETT, Katy = - Louise; c/o F-star Biotechnology Limited, Eddeva B920, Babraham Research Campus, Cambridge Cambridgeshire =_ CB22 3AT (GB). GASPAR, Miguel; c/o F-star Biotech- - nology Limited, Eddeva B920, Babraham Research Cam- = _ pus, Cambridge Cambridgeshire CB22 3AT (GB). KRA- = _ MAN, Matthew; c/o F-star Biotechnology Limited, Edde- va B920, Babraham Research Campus, Cambridge Cam- bridgeshire CB22 3AT (GB). KMIECIK, Katarzyna; c/ = _ o F-star Biotechnology Limited, Eddeva B920, Babraham = Research Campus, Cambridge Cambridgeshire CB22 3AT (GB). FOSH, Natalie; c/o F-star Biotechnology Limited, = = = Eddeva B920, Babraham Research Campus, Cambridge = Cambridgeshire CB22 3AT (GB). = = (74) Agent: KEIRSTEAD, Tanis et al.; Mewburn Ellis LLP, = City Tower, 40 Basinghall Street, London, Greater London = EC2V 5DE (GB). = Designated States (unless otherwise indicated, for every (81) = kind of national protection available): AE, AG, AL, AM, — AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, = _ 1-1 in kr) kr) 0 ei ! (54) Title: LAG -3 BINDING MEMBERS IN (57) : The present invention relates to specific binding members which bind to lymphocyte- activation gene 3 (LAG-3). The 0 specific binding members preferably comprise a LAG-3 antigen-binding site which may be located in two or more structural loops \" of a CH3 domain of the specific binding member. The specific binding members of the invention find application, for example, in 0 cancer therapy.