Patent SG-11201809126R-A (SG)
Title: Aromatic sulfonamide derivatives
Inventor: WERNER STEFAN
IPC: C07D471/04
Filed: 2017-04-26
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 1111111111111111111111111111111111111111 01111111111111111111111111111111111110111111 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/191000 Al 09 November 2017 (09.11.2017) W I P0 I P C T (51) International Patent Classification: (72) Inventors: WERNER, Stefan; EhrenbergstraBe 8, 10245 C07D 213/85 (2006.01) C07D 207/333 (2006.01) Berlin (DE). MESCH, Stefanie; Ulmenallee 45, 14050 C07D 231/12 (2006.01) C07D 207/416 (2006.01) Berlin (DE). CLEVE, Arwed; Konstanzer Str. 8, 10707 C07D 231/14 (2006.01) C07D 213/40 (2006.01) Berlin (DE). BRAUER, Nico; Ruppiner Str. 103, C07D 231/16 (2006.01) C07D 213/61 (2006.01) 14612 Falkensee (DE). HERBERT, Simon, Anthony; C07D 231/18 (2006.01) C07D 213/64 (2006.01) ChausseestraBe 88D, 10115 Berlin (DE). KOCH, Markus; C07D 233/16 (2006.01) C07D 213/65 (2006.01) Eschengraben 16, 13189 Berlin (DE). DAHLLOF, Henrik; C07D 233/61 (2006.01) CO7D 213/74 (2006.01) Sagargatan 6c, 753 17 Uppsala (SE). OSMERS, Maren; CO7D 233/64 (2006.01) CO7D 231/38 (2006.01) Zum Exerzierhaus 12, 14469 Potsdam (DE). HARDAK- CO7D 233/68 (2006.01) CO7D 231/56 (2006.01) ER, Elizabeth; 90 Mellison Road, Tooting SW17 9AY CO7D 401/04 (2006.01) CO7D 239/30 (2006.01) (GB). LISHCHYNSKYI, Anton; Benrather SchloBallee CO7D 235/06 (2006.01) CO7D 249/06 (2006.01) 15, 40597 Diisseldorf (DE). C07C 311/40 (2006.01) C07D 249/18 (2006.01) C07D 403/04 (2006.01) C07D 249/20 (2006.01) CO7D 237/08 (2006.01) CO7D 263/32 (2006.01) (74) Agent: BIP PATENTS; Alfred-Nobel-Str. 10, 40789 Mon- heim am Rhein (DE). CO7D 405/04 (2006.01) CO7D 271/04 (2006.01) (81) Designated States (unless otherwise indicated, for every CO7D 239/26 (2006.01) CO7D 275/02 (2006.01) kind of national protection available): AE, AG, AL, AM, CO7D 405/06 (2006.01) CO7D 277/26 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CO7D 239/34 (2006.01) CO7D 277/34 (2006.01) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, CO7D 239/42 (2006.01) CO7D 277/56 (2006.01) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, - CO7D 249/08 (2006.01) CO7D 213/60 (2006.01) HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, CO7D 249/10 (2006.01) A61K 31/41 (2006.01) KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, = CO7D 249/12 (2006.01) A61P 35/00 (2006.01) MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, CO7D 249/14 (2006.01) A61P 37/00 (2006.01) PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, CO7D 471/04 (2006.01) A61P 25/02 (2006.01) SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, = CO7D 261/08 (2006.01) A61P 25/28 (2006.01) TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. CO7D 271/06 (2006.01) A61P 25/16 (2006.01) (84) Designated States (unless otherwise indicated, for every (21) International Application Number: PCT/EP2017/059882 kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = International Filing Date: ZM, ZW), Eurasian AZ, BY, KG, KZ, RU, TJ, UG, (AM, = (22) 26 April 2017 (26.04.2017) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, _ _ EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Filing Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = (25) Publication Language: English TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). = - (26) = (30) Priority Data: = 16167996.4 03 May 2016 (03.05.2016) EP Declarations under Rule 4.17: - as to applicant's entitlement to apply for and be granted a (71) Applicant: BAYER PHARMA AKTIENGESEL- LSCHAFT [DE/DE]; Miillerstr. 178, 13353 Berlin (DE). patent (Rule 4.17(H)) = = = (54) Title: AROMATIC SULFONAMIDE DERIVATIVES (57) : Substituted aromatic sulfonamides of formula (I) pharmaceutical 0 1-1 I I compositions and combinations comprising said compounds and the use of said 0 =S -N H 2 compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease. © R 2 c 2 © 0 R 1-1 (I ) O\ X 1-1 „.......--„,,::::..., - N IN 1-1 I R 5 R 2b © ei O [Continued on next page] WO 2017/191000 Al MIDEDIMOMMIDIRMEMOMOIHMOIONNIHMEMOIMIE Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of