baber/WOPTO huggingface dataset:
Patent PT-2087879-E (PT)
Title: Skin toning agent with dha on a water-wax-oil basis
Inventor: GOLZ-BERNER KARIN
IPC: A61K8/35
Filed: 2009-02-06
Abstract: Cosmetic skin coloring agent comprises: dihydroxyacetone (1-3 wt.%); water (8-35 wt.%); wax (5-30 wt.%); oil (3-35 wt.%); pigment (1-7 wt.%); and further cosmetic auxiliary materials and/or carrier materials with the exception of emulsifiers for the emulsification of water- and oil-phase, where the ratio of wax and oil is 0.8-1:1.5-3 and the skin coloring agent forms a solid mass at room temperature. An independent claim is included for the preparation of cosmetic skin coloring agent, comprising producing a homogeneous water phase comprising dihydroxyacetone and water-soluble cosmetic auxiliary materials at 50-60[deg] C under stirring, producing homogeneous oil phase comprising oil, wax and pigment at 75-88[deg] C, cooling the obtained mixture at 18-25[deg] C, heating the cooled mass at 68-70[deg] C, molding the heated mixture into molds and cooling the filled molds for a period of 6-10 minutes at room temperature.
Patent PT-2179737-E (PT)
Title: Modulating responsiveness to steroids
Inventor: SPIIK ANN-KRISTIN
IPC: A61K31/7088
Filed: 2006-06-30
Abstract: The present invention makes it possible to enhance steroid efficacy in a steroid refractory patient afflicted with an inflammatory condition not responding or responding poorly or inadequately to anti-inflammatory treatment, by administering an effective to said patient amount of an oligonucleotide comprising the sequence TTCGT and having a total length of up to 100 nucleotides.  The invention also encompasses the use of said oligonucleotide for the manufacture of pharmaceuticals.
Patent PT-2281563-E (PT)
Title: 2,4-pyrimidinediamine compounds and their uses
Inventor: LI HUI
IPC: A61K31/506
Filed: 2003-01-31
Abstract: The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signalling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signalling cascades.
Patent PT-2422895-E (PT)
Title: Method and device for punching holes in double-walled materials
Inventor: WESSELS JASPER JOHANNES
IPC: B21D28/30
Filed: 2010-08-25
Abstract: It is described a method of making holes in a first plate (1) and in a second plate (2) situated at a distance (3) from the first plate. The method comprises the steps of punching a hole in the first plate by means of a punch nipple (5); punching a concentric part (CP) which includes the hole out of the first plate (1); punching a hole in the second plate by means of the punch nipple (5); and pushing the punched out concentric part (CP) onto the hole into the second plate (2). This results in increased strength and stress characteristics especially around the hole in the second plate (2), which in turn may result in material savings, especially if the method is applied to a hollow rim of a wheel winch is to be provided with spokes by means of spoke nipples attached to the rim.
Patent PT-2328420-E (PT)
Title: An apparatus for thawing food products
Inventor: HOEGNASON ALBERT
IPC: A23B4/06
Filed: 2010-04-23
Abstract: This invention relates to an apparatus for thawing or cooling food products. A tank is provided adapted to be at least partly filled with a liquid. A spiral shaped blade extends between a first end and a second end of the tank, where the spiral shaped blade is mounted to a rotation axis which operates rotational movement of the spiral shaped bladed and thus the conveying of the food products from the first end towards the second end. A temperature controlling system is provided which is adapted to control a the temperature of the liquid by arranging multiple heat supplying units along the tank for injecting heating or cooling agents into the liquid so as to provide a substantial temperature distribution into the thawing liquid during the thawing or cooling of the food products.
Patent PT-649658-E (PT)
Inventor: BROWN MARTIN J
IPC: A61K33/243
Filed: 1994-09-19
Abstract: The present invention provides methods for treating mammalian cancer tumors, preferably solid tumors, comprising administering to a mammal in need of such treatment an effective amount of a 1,2,4-benzotriazine oxide as defined in Formula I or pharmacologically acceptable salts of said compound; and administering to the mammal from about one half hour to about twenty-four hours after administering the 1,2,4-benzotriazine oxide an effective amount of a chemotherapy agent to which the tumor is susceptible. The invention also provides kits for treatment of such tumors which comprise a chemotherapy agent and a cytotoxicity-enhancing amount of a 1,2,4-benzotriazine oxide as defined in Formula I.
Patent PT-695788-E (PT)
Inventor: GODARD ERIC
IPC: C08L95/00
Filed: 1995-08-03
Abstract: In a composite emulsion for the running surfaces of traffic, contg. a bituminous binder and a resin, the emulsion is applied cold. The bituminous binder includes a cross-linking agent for the resin, and the bituminous binder and the resin are each emulsified in water before being mixed.
Patent PT-804572-E (PT)
Title: Fusion protein comprising bptk7
Inventor: MATTHEWS WILLIAM
IPC: C12Q1/6876
Filed: 1995-04-04
Abstract: Agonist antibody is disclosed which binds to the extracellular domain of receptor protein tyrosine kinase pTK, and thereby cause dimerization and activation of the intracellular tyrosine kinase domain thereof. The antibody is useful for activating its respective receptor and thereby enabling the role of the tyrosine kinase receptor in cell growth and/or differentiation to be studied. Chimeric proteins comprising the extracellular domain of the receptor pTKs and an immunoglobulin constant domain sequence are also disclosed.
Patent PT-768164-E (PT)
Inventor: GELLERT JOBST ULRICH
IPC: B29L22/00
Filed: 1996-10-11
Abstract: Disclosed is a pair of thread split inserts (12,14) used for injection moulding a bottle preform neck portion, each having (a) a rear end (30), a pair of flat aligned faces (32,34) and a curved inner surface (36), wherein (b the curved inner surface (36) is generally semi-circular, and incorporates a semi-circular groove (38) and a thread portion (40), and (c) each insert is provided with upper (42) and a lower (44) tapered flange portions, (d) each insert is provided with a cooling fluid conduit (50).
Patent PT-804529-E (PT)
Inventor: LARSON BERND
IPC: C11D3/08
Filed: 1996-01-09
Abstract: A spray-dried amorphous alkali metal silicate compound which provides multiple-cycle washing performance. The silicate compound has a molar ratio of M2O to SiO2 of 1:1.5 to 1:3.3 wherein M represents an alkali metal. The compound contains 0.5 to less than 30% by weight of anionic surfactant and has an absorption capacity for liquid components which is at least 20% higher than that of the same quantity of the alkali metal silicate compound which is free from anionic surfactant.
Patent PT-934419-E (PT)
Inventor: HORBEZ DOMINIQUE
IPC: C12N11/08
Filed: 1997-10-24
Abstract: Production of 2-hydroxy-4-methylthiobutyric acid (I) and/or its ammonium salt (Ia) from 2-hydroxy-4-methylthiobutyronitrile (II) comprises contacting (II) with an immobilised material having nitrilase (III) activity to generate (Ia), optionally converting this to free acid, and concentrating the product. Also new are: (1) an aqueous solution containing (I) and (Ia) at weight ratio (I)/[(I)+(Ia)] of 5-99.9, preferably 10-50,%; (2) a device for the process, as above, comprising reaction chambers containing immobilised (III) or host cells expressing (III), optionally an electrodialysis unit and a means of concentrating the final product; and (3) the plasmid pRPA-BCAT3 (CBS 998-96).
Patent PT-925301-E (PT)
Inventor: REDDY DASHARATHA GAURAVARAM
IPC: C07D515/00
Filed: 1997-08-15
Abstract: Novel compounds, formulations and methods of treating patients with cancer are provided for in this invention. The compounds are derivatives of camptothecin, and specifically relate to compounds having novel substitutions at the C-7 position of the camptothecin scaffold B-ring. The formula I compounds are highly lipophilic, lactone stable, do not require metabolic activation, and are potent antineoplastic compounds.
Patent PT-890630-E (PT)
Inventor: HAZEWINKEL JAKOB HENDRIK OBBO
IPC: B01D53/62
Filed: 1998-06-16
Abstract: Method for cooling polluted, carbon monoxide-containing gas, which contains as impurities at least metal vapours and hydrogen sulphide and is at a temperature of above 1 000  DEG C, to a temperature below 1 000  DEG C by supplying water in liquid and/or gaseous form to said gas under conditions such that at least some of the carbon monoxide present in the gas is able to react with the water supplied, with the formation of carbon dioxide and hydrogen.
Patent PT-908923-E (PT)
Inventor: ERNST ROLAND
IPC: H01J37/32
Filed: 1998-05-19
Abstract: The process chamber (2) for a plasma-enhanced chemical vapour deposition apparatus is of the type adapted to receive electromagnetic energy by inductive coupling from an extemal inductor (4) connected an ac supply (6), to enhance or sustain a plasma. Inside the process chamber, there is provided a conductive means (16) arranged at a predetermined distance (d) from the internal surface of at least part of is enveloping wall portions such as to inhibit coating of vapour deposition material on this internal wall surface. The conductive means can take the form of a conductive structure having an outer surface that follows an internal contour of at least part of the wall portions forming the process chamber. The conductive structure can comprise apertures (18) for facilitating the passage of electromagnetic energy into the process chamber. <IMAGE>
Patent PT-966424-E (PT)
Inventor: RACHLIN SCHNEUR
IPC: C07C225/22
Filed: 1998-01-08
Abstract: The compounds of the present invention are represented by general formula (I) in which formula R1 and R2 stand independently for one or more, similar or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, alkyl, alkoxy, alkylthio, alkylamino, or alkoxycarbonyl, the C-content of which can be from 1 to 5, cyano, carboxy, carbamoyl, phenyl, or nitro; R3 stands for hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, alkyl, alkoxy, alkylthio, alkylamino, or alkoxycarbonyl, the C-content of which can be from 1 to 5, phenyl, cyano, carboxy, or carbamoyl; R4, R5 and R6 stand independently for hydrogen, trifluoromethyl, alkyl, carbamoyl, alkoxycarbonyl, or alkyloxo, the C-content of which can be from 1 to 5; X stands for oxygen, N-OH, N-O-alkyl, dialkoxy, cyclic dialkoxy, dialkylthio, or cyclic dialkylthio, the C-content of which can be from 1 to 5. The present compounds are of value in the human and veterinary practice as systemic and topical therapeutic agents for the treatment and prophylaxis of asthma, allergy, rheumatoid arthritis, spondyloarthritis, gout, atherosclerosis, chronic inflammatory bowel disease, proliferative and inflammatory skin disorders, such as psoriasis, and atopic dermatitis.
Patent PT-1078054-E (PT)
Title: Monomeric mp52/gdf-5 with bone morphogenetic activity and medicinal agent containing the same for preventing and treating diseases of cartilage and bone
Inventor: KAWAI SHINJI
IPC: A61P1/02
Filed: 1999-05-14
Abstract: This invention provides for a protein of the TGF-beta superfamily in which the cysteine involved in the normal formation of homodimers is changed to another amino acid. These mutant proteins, as monomers, display higher bone morphogenetic activity than the wild-type protein dimers. Also provided is a method for producing and isolating these monomers by plasmid driven expression in various host systems including E. coli. In addition, the invention discloses the use of an agent containing purified monomers in preventing and treating diseases and problems affecting bone and/or cartilage.
Patent PT-1059921-E (PT)
Inventor: NAGATOMI ITSUO
IPC: A61P43/00
Filed: 1999-03-04
Abstract: Macrolide compounds, such as the FK506 Substance and its related compounds are provided for the prevention or treatment of adult respiratory distress syndrome. Composition containing such compounds is also disclosed.
Patent SG-19189-G (SG)
Title: Hot sprue valve assembly for an injection molding machine
IPC: B29C45/26
Filed: 1989-03-31
Abstract: A hot sprue valve assembly is provided for controlling flow of molten material into the mold cavity of an injection molding machine. The valve assembly is particularly designed for use with an injection molding machine for molding centrally apertured record discs, such as video information discs. The valve assembly comprises a stationary valve body supporting a movable valve member for sliding motion toward any away from the mold cavity. The valve member includes a hot sprue bushing defining a heated flow path for passage of molten material toward the mold cavity, and a dispersion head carried by the bushing for directing the molten material to flow in a generally radially outward direction through gate passages with substantially uniform radial distribution into the mold cavitiy. In one position, the valve member is advanced into the mold cavity to align the gate passages with the mold cavity and thereby permit flow of the molten material into the mold cavity. The valve member is movable to retract the gate passages from alignment with the mold cavity to prevent flow of the molten material into the mold cavity. In this retracted position, a portion of the dispersion head remains within a central portion of the mold cavity to mold a central aperture into the disc prior to soldification of the molten material.
Patent IE-830130-L (IE)
Title: Feeding-stuffs for ruminants
IPC: A23K1/00
Filed: 1983-01-24
Abstract: Feedstuffs comprise a nutritional material such as a high protein dietary supplement, carbohydrate, mineral or vitamin, protected by a coating of an edible water insoluble fatty acid salt. Such feedstuffs are capable of resisting the action of bacteria in the rumen of ruminant animals. This water insoluble salt may be formed in situ by reaction of a water-soluble fatty acid salt with a compound capable of forming a precipitate therewith, e.g. a calcium salt. Alternatively, the fatty acid salt may be formed by direct reaction of reaction of the fatty acid with e.g. calcium oxide, and the nutritional material may also be dispersed in the fatty acid salt while the latter is in the molten state.
[GB2113521A]
Patent IE-890264-L (IE)
Title: Quinazolines
IPC: C07D215/36
Filed: 1989-01-27
Abstract: Compounds of the formula (1): <CHEM>  wherein:  R<1> to R<4> are independently H, halo, (C1-C4) alkyl, branched (C3-C4) alkyl, halo (C1-C4) alkyl, (C1-C4) alkoxy, NO2, or NH2, at least two of R<1> to R<4> being H, or one of R<2> to R<4> is -NR<7>-Y-Ar or O-Y-Ar and the rest of R<1> to R<4> are H;  W is N, or CR<5>;  R<5> is H, CH3, Cl, O-Y-Ar, or -NR<7>-Y-Ar;  R<6> is H, CH3, Cl or Br;  A is -O-Alk or -X-Y-Ar; Alk is a C2-C18 saturated or unsaturated hydrocarbon chain, straight chain or branched, optionally substituted with halo, halo (C1-C4) alkoxy, (C3-C8) cycloalkyl, hydroxy, or acetyl; X is O, NR<7>, or CR<8>R<9>, provided that if one of R<2> to R<5> is NR<7>-Y-Ar or O-Y-Ar, then X-Y-Ar is an identical group;  R<7> is H, (C1-C4) alkyl, or acetyl; R<8> and R<9> are independently H, (C1-C4) alkyl, (C1-C4) acyl, halo, or OH, or R<8> and R<9> combine to form a saturated or unsaturated carbocyclic ring comprising three to seven carbon atoms; Y is an alkylene chain 2 to 8 carbon atoms long, optionally including an O, S, SO, SO2, or NR<7> group or a saturated or unsaturated carbocyclic ring comprising three to seven carbon atoms, or substituted with (C1-C3) alkyl, (C2-C4) alkenyl, phenyl, (C3-C8) cycloalkyl, hydroxy, halo, or (C1-C4) acyl; and  Ar is  1,3-benzodioxolyl  fluorenyl,  pyridyl,  imidazolyl,  indolyl,  thienyl, optionally substituted with CH3 or Cl,  thiazolyl,  cyclopentyl,  1-methylcyclopentyl,  cyclohexenyl (hexahydrophenyl),  cyclohexyl (tetrahydrophenyl),  naphthyl,  dihydronaphthyl,  tetrahydronaphthyl,  decahydronaphthyl, or  a group of the formula (2): <CHEM>  where R<1><0> to R<1><4> are independently H, halo, I, (C1-C10) alkyl, branched (C3-C6) alkyl, halo (C1-C4) alkyl, (C1-C4) alkoxy, halo (C1-C4) alkoxy, phenoxy, substituted phenoxy, phenylthio, substituted phenylthio, phenyl, substituted phenyl, NO2, NH2, acetoxy, OH, CN, or SiR<1><5>R<1><6>R<1><7>, OSir<1><5>, R<1><6>, R<1><7>, where R<1><5>, R<1><6>, and R<1><7> are independently (C1-C4) alkyl or (C3-C4) branched alkyl, provided that unless each of R<1><0> to R<1><4> is F, CH3, or H, then at least two of R<1><0> to R<1><4> are H;  or an acid addition salt of a compound of formula (1)  or an N-oxide of a compound of formula (1) when W is CR<5> are fungicides, insecticides, and miticides.
Patent IE-870286-L (IE)
Title: Pellets of magnesium-based alloy for administration to¹ruminants
IPC: A61M31/00
Filed: 1987-02-04
Abstract: A pellet or bolus for administration to a ruminant by deposition in its rumeno-reticular sac where it is eroded away by rumen juices and releases active agent(s) and/or components, either continuously or in pulsed doses, comprises or incorporates a magnesium-based alloy which comprises at least 40% of magnesium, at least 30% zinc and up to 20% aluminium and, optionally, copper up to 5%, and trace elements, selected from cobalt, manganese, nickel and selenium up to 1%, the percentages being by weight. A paste can be made by heating the alloy to between its solidus and liquidus points, when it can be admixed with lead shot for weighting the bolus. The bolus may comprises a tubular sheath which contains alloy/iron shot filling. However, the alloy can be used for any appropriate component of a bolus, e.g. as illustrated. <IMAGE>
[GB2186291A]
Patent IE-36207-L (IE)
Title: Lumilyserol derivatives
IPC: C07D457/02
Filed: 1972-03-08
Abstract: Esters of 1-methyl-lumilysergol-10-methylether having the formula:
[US3966739A]
Patent IE-840308-L (IE)
Title: Thiazinediones effective in treating skin
IPC: C07D279/06
Filed: 1984-02-10
Abstract: Skin treating composition on the basis of compatible carrier and additional compositions with a content of a defined tetrahydro-1,3-thiazine-2,4-dion derivatives as active ingredients for thickening the epidermis. The skin treating compositions are applied 1-2 times daily onto the skin for about 3 to 4 weeks. Due to the thickening of the epidermis they cause a reinforcmenet of the skin, in particular against sun rays, cold and the contact with noxious environmental substances of all kinds. Moreover, the skin treating compositions are suitable for a proplylactic fighting of the so-called old age skin. An object of the invention are novel tetrahydro-1,3-thiazine-2,4-dion derivative which are active in the aforementioned manner having the formula  <IMAGE>  wherein R denotes H, alkyl, aryl, arylalkyl has substituted arylalkyl or substituted aryl in the aryl portion, Ra=H is aryl or substituted aryl, Rb=H, denotes aryl or substituted aryl and Rc-H, represents alkyl or aryl, provided that Ra, Rb and Rconly simultaneously denote H when R denotes a substituted arylalkyl in the aryl portion and R denotes H, but only if Ra=HRb=aryl and Rc constitute=H.
Patent IE-44253-L (IE)
Title: Handling packs of glass plates
IPC: B65G49/06
Filed: 1976-02-19
Abstract: 1529013 Cradle SOC ITALIANA VETRO SIV SpA 30 Jan 1976 [20 Feb 1975] 03683/76 Heading B8H A device for use in handling stacks of plates comprises a frame 1 which has legs 2, 3 respectively pivotally connected at 9, 10 to the upper base 5 of the frame 1, the lower ends of the legs 2, 3 being pivotally attached to a lower base 4 which comprises two square tubes slidable one within the other to permit adjustment of the length of base 4 to the length of the stack being handled, bushings 11, 12 being provided at the lower ends of the legs 2, 3 respectively, in which bushings are located respective stack supports 35, 36 having a semi-cylindrical portion extending from the bushings for engagement with the lower side of a stack being handled, a cross member 20 being integrally formed with a sleeve 19 which is slidable along an upright 16 of the frame 1 to permit adjustment of the height of the cross member 20 to that of the stack, the cross member 20 comprising a central portion 21 in which two lateral tubes 22, 23 are slidable, the latter having respective sleeves 25, 26 projecting therefrom to which stack retainer plates 31, 32 are respectively adjustably attached to accommodate for various thicknesses of the stacks which are to be handled.
[GB1529013A]
Patent IE-830623-L (IE)
Title: Anode active material for alkaline cells
IPC: H01M4/42
Filed: 1983-03-22
Abstract: An anode active material of zinc powder with indium coexisting therewith, the metals being amalgamated, an alkaline cell using the anode active material therein, and a method for the production of the anode active material or the alkaline cell.
[US4812374A]
Patent IE-41011-L (IE)
Title: Artificial kidney
IPC: A61M1/22
Filed: 1975-04-22
Abstract: An artificial kidney in which blood is pumped to and from a first compartment of a dialysis apparatus and dialysis liquid is pumped to and from a second compartment thereof. The hydrodynamic resistance within these compartments is arranged so that one simultaneously maintains a first zone of the apparatus in which the pressure of the blood in the first compartment is higher than the pressure of dialysis liquid in the second compartment and a second zone in which the pressure of the blood in the first compartment is lower than the pressure of the dialysis liquid in the second compartment. By this means in the first zone ultrafiltration occurs from the blood to the dialysis liquid and in the second zone ultrafiltration occurs to inject materials back into the bloodstream from the dialysis liquid.
[US4024059A]
Patent IE-881017-L (IE)
Title: Novel 2ß-morpholino-androstane derivatives and processes for¹their preparation
Inventor: SAVAGE DAVID SAMUEL
IPC: C07J1/00
Filed: 1988-04-06
Abstract: 2-Morpholinyl-androstane derivs. of fomrula (I), their mono- and bis-quat. ammonium cpds. and the acid addn. salts of (I) or its mono-quat. ammonium cpds. are new. In the formula, R1 = H or 1-12C opt. substd. acyl; R2 = H or 1-12C acyl; R3 = CH2, N(Me) or a bond. - Pref. R1 = H; R2 = 1-6C satd. acyl; R3 = CH2 or bond; and cpds. are 16 beta-monoquat. ammonium cpds..
Patent IE-901257-L (IE)
Title: Hydroxyalkylfuranyl derivatives
IPC: A61K31/495
Filed: 1990-04-06
Abstract: Hydroxylalkylfuranyl derivatives of formula <CHEM>  wherein -A<1>=A<2>-A<3>=A<4>- is -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N-, -N=CH-N=CH- or -CH=N-CH=N- ;  D is C1-4alkanediyl ;  R<1> is hydrogen, C1-6alkyl, arylC1-6alkyl or C1-6alkylcarbonyl ;  R<2> and R<3> are hydrogen or C1-6alkyl ;  n is 0, 1 or 2 ;  B is NR<4>, O, S, SO2 or CH2;  R<4> is hydrogen, C1-6alkyl, C3-6cycloalkyl or arylC1-6alkyl ; L is hydrogen, C1-12alkyl, C3-6cycloalkyl, C3-6alkenyl optionally substituted with aryl, C1-6alkylcarbonyl, C1-6alkyloxycarbonyl, arylcarbonyl, arylC1-6alkyloxycarbonyl, C1-6alkylsulfonyl, arylsulfonyl, or a radical of formula -Alk-R<5>, -Alk-Y-R<6>, -Alk-Z<1>-C(=X)-Z<2>-R<7>, or -CH2-CHOH-CH2-O-R<8>, the acid addition salts and stereochemically isomeric forms thereof, said compounds having antiallergic activity. Pharmaceutical compositions containing such compounds as an active ingredient; methods of preparing said compounds and pharmaceutical compositions.