Patent SG-11201909547T-A (SG)
Title: Pharmaceutical composition comprising bispecific antibody constructs for improved storage and administration
Inventor: ABEL JEFF
IPC: C07K16/28
Filed: 2018-05-07
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 November 2018 (08.11.2018) WIPO I PCT omit VIII °nolo Holoimiiimommom oimIE (10) International Publication Number WO 2018/204907 Al W O 20 18/ 20 4907 Al (51) International Patent Classification: A61K 39/395 (2006.01) A61K 47/00 (2006.01) C07K 16/28 (2006.01) (21) International Application Number: PCT/US2018/031347 (22) International Filing Date: 07 May 2018 (07.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/502,578 05 May 2017 (05.05.2017) US (71) Applicant: AMGEN INC. [US/US]; One Amgen Center Drive, Thousand Oaks, CA 91320-1799 (US). (72) Inventors: ABEL, Jeff; 402 Willow Glen Circle, Simi Valley, CA 93065 (US). CUI, Lingwen; 359 Hodencamp Rd, Thousand Oaks, CA 91360 (US). GOSWAMI, De- vrishi; 2876 Capella Way, Thousand Oaks, CA 91362 (US). HUH, Joon; 4515 Berryman Ave, Culver City, CA 90230 (US). JAGANNATHAN, Bharadwaj; 1663 Amarelle St., Thousand Oaks, CA 91320 (US). KANA- PURAM, Sekhar; 5676 Via Bonita, Thousand Oaks, CA 91320 (US). MCAULEY, Arnold; C/o Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320 (US). SCHNEIDER, Michael; 617 Racquest Club Ln, Thousand Oaks, CA 91360 (US). SETHURAMAN, Ananthakrish- nan, G.; 3889 Angeline St, Newbury Park, CA 91320 (US). TREUHEIT, Michael; 807 Pamela Wood St., Newbury Park, CA 91320 (US). ZHANG, Jun; 88 Via Magnolla, Newbury Park, CA 91320 (US). (74) Agent: JANULIS, Lynn, L.; Marshll, Gerstein & Borun LLP, 233 S. Wacker Drive, 6300 Willis Tower, Chicago, IL 60606-6357 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) (54) Title: PHARMACEUTICAL COMPOSITION COMPRISING BISPECIFIC ANTIBODY CONSTRUCTS FOR IMPROVED STORAGE AND ADMINISTRATION (57) : The present invention provides an improved pharmaceutical composition for storage and administration comprising (a) a bispecific antibody construct comprising a first domain binding to a target cell surface antigen and a second domain binding to a second antigen, wherein the bispecific antibody construct is present at a concentration in the range from about 0.5 [tg/ml to 20 mg/ml, (b) a preservative at a concentration effective to inhibit the growth of microbes, and (c) a diluent wherein bispecific antibody construct is stable and recoverable.