baber/WOPTO huggingface dataset:
Patent CA-3072873-A1 (CA)
Title: Identifying oil and gas reservoirs with oxygen isotopes
Inventor: LU FENG HU
IPC: G01N33/24
Filed: 2018-08-15
Abstract: Carbonate samples are received from a wellbore formed in a geologic formation. An oxygen isotope ratio and carbon isotope ratio present within each of the carbonate samples are determined. A mineral composition of each of the carbonate samples is determined. A plot showing the determined oxygen isotope ratios versus a depth from where within the wellbore each of the carbonate samples was obtained is created. One or more negative oxygen isotope shifts are identified based on the plot. Natural carbonate cement levels within one or more of the plurality of carbonate samples that correspond to the one or more negative oxygen isotope shifts identified in the plot are determined. One or more production sweet spots are determined based on the identified negative oxygen isotope shifts and the determined natural carbonate cement levels.
Patent CA-3073746-A1 (CA)
Inventor: WECHSLER-REYA ROBERT
IPC: C12Q1/68
Filed: 2018-08-30
Abstract: Disclosed herein are methods of treating a subject by an immunotherapy in combination with a low-dose of TNF-a or an LT receptor agonist as well as methods of identifying a cancer patient as having an increased or a reduced likelihood of responding to an immunotherapy by detection of TP53 gene status, in isolation, or in combination with assays for determining the levels of MHC-I and TP53 target genes. Also provided are methods of administering an immunotherapy to select, identified cancer patients.
Patent CA-3073879-A1 (CA)
Title: Mesenchymal stem/stromal cell-derived extracellular vesicles and uses thereof in autoimmune diseases
Inventor: LEE RYANG HWA
IPC: A61K38/17
Filed: 2018-08-24
Abstract: Pharmaceutically acceptable preparations of extracellular vesicles derived from activated MSCs are provided. These preparations are essentially free of MSCs, and demonstrate anti- inflammatory inhibiting pharmacological activity in vivo. Methods for using the preparations to prevent the onset of autoimmune diseases are presented. The MSC derived extracellular vesicles are provided in pharmaceutically acceptable preparations with a carrier, such as saline, and may be used to inhibit activation of antigen presenting cells. These preparations may also be used to suppress the development of T helper 1 (Th1) and Th17 cells. The disclosed activated MSC - derived extracellular vesicle preparations are essentially free of MSCs and other cells. Methods and preparations for treating and/or inhibiting the inflammatory response attendant organ transplant, diseases including human uveitis, type 1 diabetes, scleroderma, rheumatoid arthritis, lupus, Sjorgren's syndrome, spondyloarthritides, systemic sclerosis, systemic lupus erythematosus, antiphospholipid syndrome, multiple sclerosis, anti-glomerular basement membrane disease, and pemphigoid diseases, are also provided.
Patent CA-3075187-A1 (CA)
Title: Determination of a motorcycle rider's state
Inventor: GIRAUD DAMON JAY
IPC: B60W50/10
Filed: 2018-09-06
Abstract: Force-detecting sensors are installed in a motorcycle's handlebars, footpegs and seat to detect the rider's grip, weight and weight distribution. A control unit interprets the signals from the sensors to determine an attribute of the rider or an intention of the rider to make a manoeuvre. Signals from environmental sensors are used by the control unit to determine whether the intended manoeuvre would endanger the rider, and, if so, the rider is alerted before the manoeuvre is undertaken. The alert is provided before the rider notices the hazard, or before the rider reacts to the hazard. By giving advance warning, of as little as a fraction of a second, a rider is given extra time to avert a potential accident. The control unit also controls settings of the motorcycle during a hazardous state of the motorcycle.
Patent CA-3075294-A1 (CA)
Inventor: GANSERT JENNIFER LORRAINE
IPC: A61K35/763
Filed: 2018-10-26
Abstract: Methods and compositions for treating primary hepatic cancers and/or secondary hepatic cancers using a combination of talimogene laherparepvec and pembrolizumab, a pembrolizumab variant or an antigen-binding fragment thereof are provided.
Patent CA-3075560-A1 (CA)
Inventor: VIANELLO FORTUNATO
IPC: E06B3/673
Filed: 2018-08-24
Abstract: A machine (1000) for the automatic sealing of the perimetric cavity of the insulating glazing unit (1, 1', 1", 1'''), the geometry of which is irregular in terms of flatness and shape with respect to the theoretical one, constituted by at least two glass panes (2, 2', 2", 2'", etc.) having a rectangular or other than rectangular shape and at least one spacer frame (3, 3', 3", etc., 5, 5', 5", etc.) located proximate to the perimeter at a finite distance from the margin of the glass panes or of the smaller glass pane, the glass panes being optionally aligned or offset along one or more or all the perimetric sides and the thickness both of each glass pane (2, 2', 2", 2'", etc.) and of each spacer frame (3, 3', 3", etc., 5, 5', 5", etc.) and therefore the total thickness of the insulating glazing unit (1) being variable from one insulating glazing unit to another, constituted by: at least one synchronous conveyor (100) having the function of support and displacement [together with the synchronous suction cup carriage (100')] of the insulating glazing unit (1) along the horizontal axis H during the sealing cycle; at least one synchronous carriage (200) which runs along vertical guides along the vertical axis V and is provided with the sealing head (300), the head having a synchronous rotary motion .theta. so that the sealing nozzle (301) is oriented so as to be tangent to the perimeter of the insulating glazing unit (1), or in any case the relative movement between the insulating glazing unit (1) and the sealing nozzle (301) being able to occur by means of different mechanisms and the arrangement of the insulating glazing unit (1) being any, and fed by one or more, in case of a plurality of types of sealants, synchronous volumetric units for the dosage of bi-component (400) or mono-component (450) sealant, each assembly being constituted, for the two-component case, by a dosage unit for the base product and by a dosage unit for the catalyst product, the flow rates of which are adjusted:  as a function of the stoichiometric dosage ratio, for the bi-component case, and of the dimensions of the cavity of the perimetric edge comprised between the glass panes (2, 2', 2", 2"', etc.) and the outside curve of the spacer frame (3, 3', 3", etc., 5, 5', 5", etc.) and of the relative speed between the nozzle (301) and the perimeter of the insulating glazing unit (1), so as to fill the cavity up to the extreme margin of the smaller glass pane or of the glass panes if aligned, wherein the devices (304, 501, 502) interfaced and operating in connection with the perimetric cavity of the insulating glazing unit (1) during the corresponding sealing follow without discontinuity the actual position of the cavity along the transverse axis Z, which is different from the theoretical one due to non-flatness of the insulating glazing unit (1).
Patent CA-3076159-A1 (CA)
Title: Analyzing tumor dna in a cell-free sample
Inventor: LO YUK MING DENNIS
IPC: G16B20/10
Filed: 2008-07-23
Abstract: Methods, systems, and apparatus are provided for determining whether a nucleic acid sequence imbalance exists within a biological sample. One or more cutoff values for determining an imbalance of, for example, the ratio of the two sequences (or sets of sequences) are chosen. The cutoff value may be determined based at least in part on the percentage of fetal DNA in a sample, such as maternal plasma, containing a background of maternal nucleic acid sequences. The cutoff value may also be determined based on an average concentration of a sequence per reaction. In one aspect, the cutoff value is determined from a proportion of informative wells that are estimated to contain a particular nucleic acid sequence, where the proportion is determined based on the above- mentioned percentage and/or average concentration. The cutoff value may be determined using many different types of methods, such as sequential probability ratio testing (SPRT).
Patent CA-3076519-A1 (CA)
Inventor: DISEGI JOHN A
IPC: A61L31/14
Filed: 2018-10-05
Abstract: The present invention is directed to a biodegradable alloy suitable for use in a medical implant, comprising at least 50% iron by weight, at least 25% manganese by weight, and at least 0.01%) sulfur and/or selenium by weight, wherein the biodegradable alloy is nonmagnetic. The present invention also provides a method of producing a biodegradable alloy with a desirable degradation rate.
Patent CA-3081010-A1 (CA)
Title: Systeme alimente electriquement, modulaire et mobile destine a etre utilise dans la fracturation de formations souterraines au moyen de gaz de petrole liquefie
Inventor: COLI TODD
IPC: E21B43/26
Filed: 2013-10-04
Abstract: La présente invention concerne un procédé et un système pour produire une alimentation électrique sur le site dune opération de fracturation, et un système de fracturation alimenté électriquement. Du gaz naturel peut être utilisé pour entraîner un générateur à turbine dans la production dénergie électrique. Une flotte de fracturation alimentée électriquement et évolutive est fournie pour pomper des fluides pour lopération de fracturation, éliminant la nécessité dune alimentation constante de carburant diesel vers le site et réduisant lempreinte et linfrastructure du site requises pour lopération de fracturation par rapport à des systèmes classiques. Le fluide de traitement peut comprendre un fluide de fracturation à base deau ou un fluide de fracturation fait de gaz de pétrole liquéfié (GPL) sans eau.
Patent CA-3081624-A1 (CA)
Inventor: WATSON JOHN ASHLEIGH
IPC: A61P17/02
Filed: 2019-01-04
Abstract: The present disclosure relates to birch bark extracts, methods of producing such extracts, stable pharmaceutical compositions containing such extracts and methods of using of such extracts. The birch bark extracts of the present disclosure contain triterpenes, which are known to improve wound healing.
Patent CA-3082586-A1 (CA)
Title: Viral vectors comprising rdh12 coding regions and methods of treating retinal dystrophies
Inventor: THOMPSON DEBRA A
IPC: C12N15/861
Filed: 2018-11-15
Abstract: Provided are materials, methods and uses for treating an ophthalmological condition such as Leber Congenital Amaurosis by administering an effective amount of an adeno-associated virus AAV2, serotype 5 (AAV 2/5) or AAV-5 comprising an expressible coding region for human RDH12.
Patent CA-3084913-A1 (CA)
Title: Apparatus and methods for vehicle steering to follow a curved path
Inventor: ROBINSON WILLIAM DANIEL
IPC: A01B69/00
Filed: 2020-06-25
Abstract: Methods, apparatus, systems and articles of manufacture are disclosed for vehicle steering to follow a curved path. An example vehicle disclosed herein includes a front axle, a rear axle, a location sensor, and a tracking mode controller to determine a wheel steering angle based on a turn center location corresponding to a navigation curve and one or more measurements between the turn center location and the vehicle, determine a heading error offset adjustment based on the turn center location and the one or more measurements between the turn center location and the vehicle, and cause the vehicle to move along the navigation curve based on the wheel steering angle and the heading error offset adjustment.
Patent CA-3085268-A1 (CA)
Title: A multipurpose potentiator composition and the methods thereof
Inventor: T UMAKANTHAN
IPC: A61K33/10
Filed: 2018-11-21
Abstract: Disclosed is a multipurpose potentiator composition comprising: sodium carbonate monohydrate, sodium carbonate anhydrous, potassium nitrate, sodium chloride and water such that the potentiating composition is applied to alter physical or chemical properties or both of a substance on which the potentiating composition is applied. Also provided is a container for holding the composition.
Patent CA-3085460-A1 (CA)
Inventor: KESICKI EDWARD A
IPC: C07D405/04
Filed: 2018-12-21
Abstract: The invention relates to inhibitors of PI5P4K inhibitors useful in the treatment of cancers, neurodegenerative diseases, inflammatory disorders, and metabolic diseases, having the Formula (I): wherein A, X, Y, Z, Q, R1, R2, R3, R4, R5, and n are described herein.
Patent CA-3092365-A1 (CA)
Inventor: HUO QUN
IPC: G01N15/02
Filed: 2019-03-15
Abstract: Disclosed herein are unique assay methods and devices that provide simple and quick evaluation of function, status and/or activity of an immune system of a subject. Specifically exemplified is a method that involves mixing an assay substance with a blood or blood component from the subject to form an assay product that comprises at least one unit of the assay substance and at least one molecular component of the blood or blood component; analyzing the assay product under conditions to determine an assay product property (the assay product property including a physical, chemical, optical, electrical, magnetic, and/or mechanical property); and comparing the assay product property with a correlative property of an unexposed assay substance to generate a comparative data value, wherein the comparative data value indicates the function, status and/or activity of an immune system of the subject.
Patent CA-3092711-A1 (CA)
Inventor: HOEDL PETER
IPC: B60P3/34
Filed: 2020-09-02
Abstract: The invention creates a foldable wall structure for extending the interior space of transportable constructions, in particular a vehicle such as a camper van. The foldable wall structure has a first foldable wall which, in the folded-out state, forms a base wall of the wall structure, and a second foldable wall which, in the folded-out state, forms a cover wall of the wall structure. The foldable wall structure has a foldable fourth wall and a foldable fifth wall, which, in the folded-out state, form a first and a second side wall; the wall structure also has a frame structure, in which the wall structure has a third wall that can be translationally shifted relative to the folded-in first wall, the third wall forming an outer wall of the wall structure in the shifted state.
Patent CA-3094283-A1 (CA)
Inventor: KNOWLES RICHARD
IPC: B23B51/05
Filed: 2020-09-24
Abstract: An arbor or mandrel is typically used to attach a cylindrical hole saw blade to a power drill. Hole saws come in a range of different sizes and the arbor allows them to be easily interchanged. Typical cylindrical hole saws have a common problem attendant to their normal use. The unwanted material removed by the saw in the process of cutting the hole remains in the interior of the cylindrical blade as the hole is being cut. Once the hole is complete and the saw removed from the work, this plug of material is frequently difficult and time consuming to remove from the interior of the saw before the next hole can be cut. To remove the waste material, the majority of hole saw blades are provided with slots or holes in the wall or closed end of the cylinder that allow a screwdriver blade or other object to be inserted to lever or drive the plug of material out of the blade after the hole saw is removed from the workpiece. Depending on the nature of the material being worked, the process of removing the waste from the interior of the saw can range from easy to very difficult and time consuming, and frequently requires dismounting the hole saw and mandrel from the driving drill motor. The arbor presented here is a significant improvement over existing devices as it is characterized by its ability to drive the saw and, after cutting a hole, to quickly eject the waste plug remaining stuck in the saw blade without disconnecting the power drill form the arbor.  This is accomplished in a faster, safer, easier, and less complex manner than other devices available.
Patent CA-3095373-A1 (CA)
Title: Nk cell engaging antibody fusion constructs
Inventor: TESAR MICHAEL
IPC: A61K39/00
Filed: 2019-04-12
Abstract: The invention relates to multispecific antigen-binding proteins for engaging natural killer (NK) cells for triggering NK cell cytotoxicity by engaging the CD16A (Fc?RIIIA)expressed on NK cells, wherein the antigen-binding protein comprises at least two CD16A antigen-binding moieties and at least a further target antigen-binding moiety. The CD16A antigen-binding moiety comprises light chain and heavy chain variable regions linked one after another in a polypeptide chain and the variable region at the N-terminus of the polypeptide chain comprising the CD16A antigen-binding moiety is a light chain variable region.
Patent CA-3095937-A1 (CA)
Inventor: PILLAI RADHAKRISHNAN
IPC: A61K35/74
Filed: 2019-04-05
Abstract: La présente invention concerne des compositions pharmaceutiques topiques destinées à traiter une maladie ou affection cutanée. Les compositions pharmaceutiques topiques peuvent être formulées sous la forme de lotions contenant une quantité thérapeutiquement efficace d'un agent actif, tel que la trétinoïne, un agent augmentant la viscosité et des quantités avantageusement faibles d'un émulsifiant polymère et d'un constituant huileux. Selon la présente invention, les compositions topiques offrent une tolérance exceptionnelle chez des sujets auxquels les compositions sont administrées.
Patent CA-3097649-A1 (CA)
Title: Proteines de fusion heterodimeres ciblant lag-3 contenant des proteines de fusion fc d'il-15/il-15ra et domaines de liaison a l'antigene de lag-3
Inventor: BERNETT MATTHEW
IPC: A61K38/20
Filed: 2019-04-18
Abstract: La présente invention concerne de nouvelles protéines de fusion hétérodimères ciblées comprenant une protéine de fusion Fc d'IL-15/IL-15Ra et une protéine de fusion de fragment-Fc d'anticorps LAG-3.
Patent CA-3099220-A1 (CA)
Title: Heat recovery from vacuum blowers on a paper machine
Inventor: SEALEY JAMES E
IPC: D21F5/14
Filed: 2020-11-13
Abstract: ABSTRACT A papermaking process including the steps of forming a wet paper web on a papermaking machine, pulling vacuum through the web to remove water from the web and thereby generate discharge air, and diverting at least a portion of the discharge air through a control loop to a hot air drying system within the papermaking process to aid in drying the web, wherein the vacuum is generated by centrifugal blowers. 4824-9866-4620v.1 Date Recue/Date Received 2020-11-13
Patent CA-3100819-A1 (CA)
Title: Fish gutting device with controllable cutting
Inventor: KRISTENSEN IVAN
IPC: A22C25/14
Filed: 2019-06-12
Abstract: The invention provides a gutting device for gutting a fish along its abdominal cavity. A blade for cutting the fish open, and a shielding element are movably mounted on a controllable movable arm. The shielding element has a blunt tip, and it is arranged for being in: 1) a retracted position, where the shielding element allows the blade to cut the fish, 2) a tracking position, where the blunt tip of the shielding elements is inside the abdominal cavity of the fish, so as to track the end of the abdominal cavity of the fish, and 3) a shielding position, where the shielding element is pushed upwards by contact with the end of the abdominal cavity at a genital opening of the fish, thereby shielding the blade from further contact with the fish. This provides a precise method for without unintentionally damaging the fish.
Patent CA-3105425-A1 (CA)
Title: System for generating indications of neurological impairment
Inventor: MAZZA CHRISTOPHER
IPC: A61B5/16
Filed: 2019-07-03
Abstract: A system for generating indications of neurological impairment is described. Baseline test data is gathered from neurological functioning tests performed on individuals at regular intervals via mobile devices. The system receives test data and updates baselines of expected neurological functioning for individuals. After an individual experiences an impairment, the system receives post-impairment test data from a mobile device associated with the individual and probabilistically determines a likelihood that the post-impairment test data is indicative of neurological impairment, and the system outputs an indication of the likelihood thereof.
Patent CA-3108588-A1 (CA)
Title: Data transmission method and device, and terminal
Inventor: XU YANG
IPC: H04L1/18
Filed: 2019-03-19
Abstract: Provided are a data transmission method and device, and a terminal, the method comprising: a terminal executing a first action according to first information, wherein the first action is that at least one user module of the terminal transmits the same application data via multiple connections.
Patent CA-3109008-A1 (CA)
Inventor: HUO JUNYAN
IPC: H04N19/159
Filed: 2018-08-09
Abstract: A video image component prediction method and device, and a computer storage medium. The method comprises: acquiring at least one threshold value according to first image component reconstruction values of all sampling points of a current coding block (S601); carrying out grouping according to a comparison result of a first image component neighboring reference value of the current coding block and the at least one threshold value, so as to obtain at least two groups of first image component neighboring reference values and second image component neighboring reference values (S602); establishing at least two computing models according to the at least two groups of first image component neighboring reference values and second image component neighboring reference values (S603); selecting, from the at least two computing models, a computing model corresponding to each sampling point in the current coding block according to a comparison result of the first image component reconstruction values of all the sampling points of the current coding block and the at least one threshold value (S604); and according to the computing model corresponding to each sampling point in the current coding block, acquiring a second image component prediction value of each sampling point in the current coding block (S605).
Patent CA-3109211-A1 (CA)
Inventor: HOPE HELGE
IPC: E21B19/16
Filed: 2018-08-15
Abstract: A method is described for supply of liquid from a liquid storage to a casing string (10,12, 14..) which from a deck (16) on an installation is conveyed down in a well with the help of a pipe handler comprising an elevator, where the liquid is supplied via an uppermost casing (10) which is added to the casing string, and the liquid is supplied through a filling pipe (30) via an outlet nozzle (36) to the top of the casing (10) already during the pipe's (10) screwing into the casing string (10, 12, 14..) where the filling pipe is extended during the liquid supply until the casing string is being lowered down to a position where it is securely locked to the deck (16), and liquid is added to a suitable level in the casing string. The method is characterised in that the filling pipe (30) is extended in that it comprises a telescopic axially moveable pipe end part (35) with a constricted outlet (36) which leads to the pipe end part (35) being pushed axially outwards and extends the filling pipe (30) when the liquid is supplied under pressure, and the pipe end part (35) is pushed outwards under the counter effect of a prestressing force, and pulled back under the influence of said prestressing force when the liquid supply stops. Also described is a device as given in claim 10.
Patent CA-3109212-A1 (CA)
Inventor: GARCIA ARMENTA PATRICIA DEL CARMEN
IPC: A61K31/415
Filed: 2019-09-12
Abstract: The present invention relates to a pharmaceutical composition comprising a synergic combination of a selective inhibitor of cyclooxygenase-2 (COX-2), such as the active substance celecoxib, and an agent derived from anthraquinone, such as the active substance diacerein, which are formulated with pharmaceutically acceptable additives and/or excipients and/or vehicles in a single dosing unit to be administer orally, parenterally, topically, transdermally or by devices for oral or nasal inhalation. The composition is suitable for the treatment of pain and inflammation in osteoarthritis, rheumatoid arthritis and/or degenerative joint disease caused by different aetiologies.