baber/WOPTO huggingface dataset:
Patent JP-3057759-B2 (JP)
IPC: C12N1/21
Filed: 1990-11-30
Granted: 2000-07-04
Abstract: A process for producing 7-aminocephem compounds, or salts thereof, which comprises cultivating in a nutrient medium a microorganism capable of producing a 7-aminocephem compound of the formula: <CHEM> wherein R is acetoxy, hydroxy or hydrogen, and recovering the compound (I) or a salt thereof from the culture broth. An example of a suitable 7-aminocephem compound-producing microorganism is a fungal strain belonging to the species Acremonium chrysogenum that is capable of producing a cephalosporin compound of the formula: <CHEM>  wherein R is as above and X is -CH(NH2)-COOH, -CO-COOH or -COOH, said fungal strain having been transformed with a 7-aminocephem compound production vector containing one or more promoters for Acremonium chrysogenum and gene(s) connected therewith which encodes enzyme(s) capable of converting the cephalosporin compound (II) to the 7-aminocephem compound (I). A vector for use in the process, cephalosporin compound-producing microorganisms transformed with said vector and a DNA fragment having the promoter activity of the Acremonium chrysogenum alkaline protease gene are also described.
Patent JP-3124753-B2 (JP)
IPC: H01S3/082
Filed: 1998-11-30
Granted: 2001-01-15
Abstract: Peptides and proteins related to an epitope comprising an outer membrane protein of Haemophilus influenzae. The peptides and proteins can be prepared by methods including novel and improved methods of purification from H. influenzae cultures, and by recombinant DNA and chemical synthetic techniques. Additionally, recombinant vectors containing nucleotide sequences encoding PBOMP-1 related peptides and proteins are also described. Recombinant vectors include plasmid DNA and viral DNA such as human viruses, animal viruses, insect viruses and bacteriophages that direct the expression of PBOMP-1 related peptides and proteins in appropriate host cells. The peptides, proteins and viruses both "live" and "inactivated" are used as immunogens in vaccine formulations to protect against H. influenzae infections. The peptides and proteins are also used as reagents in immunoassays as well as to prepare immunoglobulins for passage immunization. Use of the nucleotide sequences encoding the PBOMP related peptides and proteins in hybridization assays is also described.
Patent JP-4068162-B2 (JP)
IPC: C08L33/06
Filed: 1998-05-22
Granted: 2008-03-26
Abstract: Disclosed is a process for producing a polymer blend wherein a first phase containing a polyacrylate polymer prepared by radical polymerization and a source of radicals, and a second phase containing a polyolefin polymer are compounded by melt processing.
Patent JP-3214706-B2 (JP)
IPC: D01F2/00
Filed: 1997-06-05
Granted: 2001-10-02
Abstract: PCT No. PCT/KR97/00104 Sec. 371 Date Feb. 10, 1999 Sec. 102(e) Date Feb. 10, 1999 PCT Filed Jun. 5, 1997 PCT Pub. No. WO97/47790 PCT Pub. Date Dec. 18, 1997A simple method of preparing a homogeneous cellulose solution is disclosed, which comprises the steps of (a) preparing fibrillar cellulose powder; (b) injecting a molten liquid tertiary amine oxide solvent into a twin screw extruder; (c) feeding the cellulose powder of step (a) into a section of the twin screw extruder where the molten liquid tertiary amine oxide solvent fed in step (b) produces a well swollen paste with the cellulose powder fed in step (c); (d) dissolving the well swollen cellulose paste in the following melting sections in the twin screw extruder; and (e) stabilizing the solution obtained in step (d) in a storage tank.
Patent JP-3223188-B2 (JP)
IPC: H03H17/00
Filed: 1991-12-13
Granted: 2001-10-29
Abstract: PCT No. PCT/SE91/00860 Sec. 371 Date Mar. 17, 1994 Sec. 102(e) Date Mar. 17, 1994 PCT Filed Dec. 13, 1991 PCT Pub. No. WO92/11696 PCT Pub. Date Jul. 9, 1992.A digital filter bank analyzer for reducing power consumption by decreasing the number of multiplications carried out therein. There is particularly provided a filter bank analyzer for use in battery-operated applications. The digital filter bank analyzer includes a zero-filled expanded digital basic filter [H1(z)] having a complementary output, and downstream, parallel part-filter banks [HD1,HD2]. In the present context, a zero-filled filter pertains to a filter which may be used on an LP-filter that which is expanded with a number of zero-filter coefficients between each coefficient in the original filter. The part-filter bank [HD1] connected to the normal output of the basic filter [H1(z)] is intended to filter-out those filter-bank bands which are pass bands to the basic filter, so that only one of the filter-bank bands is found on each output signal from said one part-filter bank [HD1]. The other part-filter bank [HD2] connected to the complementary output of the basic filter [H1(z)] is intended to filter-out those filter-bank bands which are pass bands to the complementary output of the basic filter, so that only one filter-bank band is found on each output signal from the second part-filter bank [HD2].
Patent JP-2554396-B2 (JP)
IPC: A61K31/765
Filed: 1989-12-28
Granted: 1996-11-13
Abstract: In accordance with the present invention, a method and composition is provided for treating pathological hydrophobic interactions in biological fluids in which there is acute impairment of the circulation, especially the microcirculation. More particularly, the present invention relates to compositions and methods for treating circulatory diseases comprising using certain ethylene oxide-propylene oxide condensation surface active copolymers either alone or in combination other compounds. Also contemplated in the present invention is a method for preserving a suspension of platelets. The method comprises adding an effective amount of a surface active copolymer. The surface active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula; HO(C2H4O)b(C3H6O)a(C2H4O)bH wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight of approximately 950 to 4000, preferably approximately 1750 to 3500, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 50% to 95% by weight of the compound.
Patent JP-2779857-B2 (JP)
IPC: A61F2/00
Filed: 1989-01-31
Granted: 1998-07-23
Abstract: A prosthetic knee joint (10,12,13) is provided having an extended position (Figure 7), an intermediate position (Figure 8), and a flexed position (Figures 9 and 10). The motion of the joint includes a minor segment from the extended position to the intermediate position, and a major segment from the intermediate position to the flexed position. The center of pressure between the femoral component (10) and the tibial component (12) moves rearward on the tibia during the minor segment. During the major segment, the joint flexes about an axis of rotation (common center of radii R3 and R4) with the bearing surfaces (20c,20d,34c,34d) on the femoral (10) and tibial (12) components being in congruent engagement. The distal surface of the femoral component (10) includes two rails (88) for engagement with a patellar prosthesis (80). <IMAGE>
Patent JP-2602820-B2 (JP)
IPC: G01G11/00
Filed: 1986-04-01
Granted: 1997-04-23
Abstract: PCT No. PCT/EP86/00187 Sec. 371 Date Nov. 6, 1986 Sec. 102(e) Date Nov. 6, 1986 PCT Filed Mar. 27, 1986 PCT Pub. No. WO86/05875 PCT Pub. Date Oct. 9, 1986.An apparatus for the automatic determination of a continuous bulk material throughput through a continuous balance comprises a weighing vessel, an adjustable closure member for adjusting an outlet cross-section of the weighing vessel and an electronic weight difference measuring device. The closure member is connectable to the weighing vessel in the outlet region thereof which is formed as an adjustable wall part and is so arranged that when the closure member is in the open operating position, there is a free mass flow in the weighing vessel. Simultaneously it is ensured that the bulk material flows freely and unhindered from the outlet of the weighing vessel. In the process of the automatic determination of the bulk material throughput while using the apparatus either when maintaining a mass flow in the complete weighing vessel or with the mass flow stopped, a signal corresponding to the weight change in the weighing vessel per unit of time is derived and used for calculating the parameters of state of the bulk material flow.
Patent JP-3959109-B2 (JP)
IPC: F16D51/00
Filed: 1995-06-30
Granted: 2007-08-15
Abstract: A brake, comprising a connecting mechanism enables the driving member to bring the driven member into their common movement, a fixed seat having friction surface and a braking part connected on the driven part; said connecting mechanism comprising an acting block and a driving block, the two can match together in relative movement and make relative movement when the driving member acquired active force or lost active force, enables the driven block making relative displacement on the direction of fitting or disengaging movement relative to the driven member, to realize braking or relieve braking for the driven member; said connecting mechanism also comprises a limiting mechanism, used for restricting the distance of relative movement of the acting block and driving block, and when braking or relieving braking has been accomplished, enables them to be in the state of common movement.
Patent JP-H0262960-B2 (JP)
IPC: B32B15/08
Filed: 1985-11-05
Abstract: An RFI shielded enclosure and a process for making same are disclosed. The process comprises coating at least one surface of the enclosure with a fluid organic binder having a substantial percentage of catalytic particles suspended therein. The particles used cause the electroless deposition of copper or nickel to produce an RFI shielded enclosure having in excess of 40 dB's shielding at frequencies above 10 kiloHertz.
Patent JP-2641934-B2 (JP)
IPC: G01N33/546
Filed: 1988-07-01
Granted: 1997-08-20
Abstract: Immobilization method comprising mixing with polyazetidine, dewatering, sub-dividing and curing. The method is useful for enzymes, cell mass, coenzymes and antibodies. The product is physically strong, and less cross-linking agent can be used than in prior-art processes.
Patent JP-3310298-B2 (JP)
IPC: C12N9/50
Filed: 1996-08-20
Granted: 2002-08-05
Abstract: The process according to the present invention allows expression and isolation of polypeptides with the proteolytic activity of HCV NS3 protease in a pure, catalytically active form, and in amounts that are sufficient for discovery of NS3 protease inhibitors and for determination of the three-dimensional structure of the NS3 protease. A further subject of the present invention is a procedure that defines the chemical and physical conditions necessary for completion of the proteolytic activity of the above polypeptides. The invention further comprises new compositions of matter (expression vectors) containing nucleotide sequences capable of expressing the above mentioned polypeptides in culture cells. Finally, new compounds of matter are defined, suitable to measure the above proteolytic activity, and useful to develop NS3 protease inhibitors and therefore therapeutic agents for use against HCV. The figure shows the kinetic parameters of HCV NS3 protease using the S3 depsipeptide substrate (SEQ ID NO:45).
Patent JP-3084749-B2 (JP)
IPC: H01J49/42
Filed: 1992-11-10
Granted: 2000-09-04
Abstract: A mass spectrometry method in which a trapping field signal (such as a three-dimensional quadrupole trapping field signal or other multipole trapping field signal) set to store ions of interest is superimposed with a notch-filtered broadband ("filtered noise") signal, and ions are formed or injected in the resulting combined field. The filtered noise signal resonates all ions (except selected ones of the ions) from the combined field, so that only selected ones of the ions remain trapped in the combined field. The combined filtered noise and trapping field signal (the "combined signal") is then changed to excite the trapped ions sequentially, so that the excited ions can be detected sequentially. The invention can be applied to perform an (MS)n or CI, or combined CI/(MS)n, mass spectrometry operation.
Patent JP-3490445-B2 (JP)
IPC: C07D495/14
Filed: 1993-11-27
Granted: 2004-01-26
Abstract: Triazolopyrimidines of the formula    <IMAGE>  I  where A, D and X have the meanings stated in the description, and their preparation are described. The novel compounds are suitable for controlling diseases.
Patent JP-3250156-B2 (JP)
IPC: G06F12/08
Filed: 1994-01-19
Granted: 2002-01-28
Abstract: A method and apparatus for sharing a single storage device among an arbitrarily large number of parallel processes with typically no wasted memory space and continued operations even when an error or interrupt occurs is disclosed. In a networked computer system having a communication network connecting a primary storage device between one or more computer devices and a secondary storage device, when some type of interrupt is generated or an error condition occurs or is otherwise indicated, a transfer of data from primary to secondary storage is indicated. A state indicator having at least a non-backup and a backup state may be set to the backup state to indicate that a data transfer from the primary storage device to the secondary storage device should occur. Alternatively, the transfer from the primary to the secondary storage device can begin without the use of a state indicator. When the state indicator is in the backup state, a predetermined maximum number of processes will work on transferring data from the primary storage device to the secondary storage device. Other processes will transfer data from the computer to the primary storage device. The process which completes the transfer of data from the primary storage device to the secondary storage device then resets the state indicator to its normal state. Preferably, other processes which are already executing at the time when the state indicator is set to the backup state continue to execute to completion.
Patent JP-3701966-B2 (JP)
IPC: C12N15/87
Filed: 1994-01-26
Granted: 2005-10-05
Abstract: Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a polynucleotide function enhancer and administering to the cells, a nucleic acid molecule that is free of retroviral particles. The nucleic acid molecule comprises a nucleotide sequence that encodes a protein that comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen or an antigen associated with a hyperproliferative or autoimmune disease, a protein otherwise missing from the individual due to a missing, non-functional or partially functioning gene, or a protein that produces a therapeutic effect on an individual. Methods of prophylactically and therapeutically immunizing an individual against HIV am disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
Patent JP-3217372-B2 (JP)
IPC: D21F11/00
Filed: 1994-12-19
Granted: 2001-10-09
Abstract: The present invention provides a wet pressed paper web. The web has a first relatively high density region having a first thickness K, a second relatively low density region having a second thickness P, which is a local maxima, and a third region extending intermediate the first and second regions. The third region includes a transition region having a third thickness T, which is a local minima. The present invention also provides a method of making a wet pressed web. An embryonic web of papermaking fibers is formed on a foraminous forming member, and transferred to an imprinting member to deflect a portion of the papermaking fibers in the embryonic web into deflection conduits in the imprinting member. The web and the imprinting member are then pressed between first and second dewatering felts in a compression nip to further deflect the papermaking fibers into the deflection conduits in the imprinting member and to remove water from both sides of the web. The imprinting member can have a continuous, monoplanar web contacting surface for molding a wet paper web to have a continuous, relatively high density network and a plurality of relatively low density, discrete domes dispersed through the relatively high density network.
Patent JP-3732854-B2 (JP)
IPC: B06B1/06
Filed: 1994-01-14
Granted: 2006-01-11
Abstract: An ultrasound catheter is disclosed for providing substantially real-time images of small cavities. The ultrasound catheter is characterized by separate and distinct materials for backing the transducers and for carrying the electronics components. The separate materials comprise an electronics carrier meeting the requirements for holding the integrated circuitry of the ultrasound device and a backing material displaying superior characteristics relating to reducing ringing and minimizing the effect of other sources of signal degradation in the transducer assembly. Also, in accordance with the present invention, a technique is described for connecting the conductor lines of the separate transducer assembly and electronics body. <IMAGE>
Patent JP-3911294-B2 (JP)
IPC: F16H25/24
Filed: 1996-11-12
Granted: 2007-05-09
Abstract: PCT No. PCT/DE96/02170 Sec. 371 Date May 13, 1998 Sec. 102(e) Date May 13, 1998 PCT Filed Nov. 12, 1996 PCT Pub. No. WO97/18406 PCT Pub. Date May 22, 1997A device for converting a rotary motion into an axial motion comprises an outer tube (10) with internal contours (10a), an inner shaft (11) with head (11a) with external contours (11b), an inner chamber (R) formed between tube (10) and shaft (11) and a plurality of roller elements (12) arranged in the inner chamber (R) and around the head (11a), which are in active engagement with at least one contour with the internal contour (10a) of the tube (10) and the external contour (11b) of the head (11a), whose position can be adjusted essentially by rotation relative to the roller elements (12). The shaft (11) is surrounded by a tubular element (14) arranged coaxially with respect to the central axis (a-a) of the shaft, which moves translationally relative to the tube (10) when the device is actuated. By this the device is protected in a most simple way from exterior influences: (FIG. 2).
Patent JP-3117466-B2 (JP)
IPC: C07C235/38
Filed: 1996-11-26
Granted: 2000-12-11
Abstract: Novel benzene derivatives of the formula (I) shown below, pharmacological salts thereof, pharmacological solvates of the above-mentioned benzene derivatives and salts, pharmaceutical compositions including, as active ingredients, the above-mentioned compounds, and especially, prophylactic or therapeutic medicines for allergic diseases. <CHEM> wherein R<1> = H, C1 - C12 cyclic or straight or branched chain alkyl group (which may be substituted by one or more C6 - C10 aryloxy groups), C7 - C12 aralkyl group (of which the aryl group may be substituted one or more of halogen, methyl and methoxy, or C3 - C10 alkenyl which may be substituted by one or more phenyl groups; A = O, S or CH2 group, B = CO or CZ2CO group (Z = H or F), R<2> = H or C1 - C4 alkyl group, X = halogen or methyl group, and Y = H, NO2 or CN group.
Patent JP-3101768-B2 (JP)
IPC: H04L29/06
Filed: 1997-01-14
Granted: 2000-10-23
Abstract: When a public switched telephone network (PSTN) subscriber (28) is occupying their telephone link to connect a personal computer to a computer network, the method provides automatic redirection of an incoming call to said telephone link to a subscriber proxy (38) connected to the PSTN (30) for producing audio interaction with the caller. The subscriber proxy is also connected to said computer network and is capable of sending and receiving messages over said computer network to the subscriber's computer thereby providing the subscriber with a capability to receive notification on said computer of the PSTN call attempt. Optionally, the subscriber has a further capability to interact with said computer to operate the proxy to control and interact with the incoming voice telephone call while the subscriber continues to occupy their telephone link connecting their computer to the computer network.
Patent JP-3176376-B2 (JP)
IPC: B29C48/03
Filed: 1996-05-08
Granted: 2001-06-18
Abstract: PCT No. PCT/DE96/00846 Sec. 371 Date Nov. 25, 1997 Sec. 102(e) Date Nov. 25, 1997 PCT Filed May 8, 1996 PCT Pub. No. WO96/38286 PCT Pub. Date Dec. 5, 1996In a filter changing device with a flow path for the plastic in which one of two or more filters can be inserted into the flow path as desired, the invention proposes to fit the filter support in such a way that it can assume a working back rinse and filter change position, in which, in the back rinse position, the plastic is caused to reverse its direction of flow through two interconnected flow channels without permitting air to penetrate into the filter changing device and in which there is free access to one of the filters in the filter changing positions. As the back rinse position can succeed a filter changing position, it is possible to clear the whole filter changing device of occluded air before a plastic processing plant starts production.
Patent JP-4582822-B2 (JP)
IPC: A61K9/00
Filed: 1997-03-06
Granted: 2010-11-17
Abstract: An ophthalmic compound with an extended dwell time on the eye, especially in the form of a drip gel, a salve or the like, containing a fluid base of increased viscosity and a preserving agent and possibly one or more active agents and common additives, like isotoning agents, substances for adjusting the pH, etc. According to the invention, the preserving agent consists essentially of a benzyl lauryl dimethyl ammonium salt. The invention also relates to the use of a benzyl lauryl dimethyl ammonium salt as a preserving agent in the production of ophthalmic compounds intended for repeated use over long periods and/or formulated for extended dwell time on the eye after each application, by means of which irritations of and/or tissue damage to the eye are prevented.
Patent JP-4014231-B2 (JP)
IPC: C07F9/09
Filed: 1998-01-27
Granted: 2007-11-28
Abstract: A process for preparing a phosphodiester of the formula: is described that involves (1) reaction of a first alcohol with phosphorous trichloride to form a phosphorodichlorodite, (2) reaction of the phosphorodichlorodite with an amine to form a phosphorodiamidite, (3) reaction with a second alcohol (which may be the same as the first alcohol) to form a phosphoramidite diester, and finally, (4) hydrolysis and oxidation of the phosphoramidite to form the phosphodiester. R and R1 may represent aliphatic, aromatic, heterocyclic, peptidic, peptoid, deoxyribo- or ribonucleotidic or nucleosidic, or organic chelating moieties.
Patent ES-2267323-B2 (ES)
Title: Variador mecanico.
Inventor: ANGULO PENA ANTONIO
IPC: B64C27/10
Filed: 2003-03-26
Granted: 2007-12-16
Abstract: Variador mecánico. Consiste en un equipo compuesto básicamente de un doble balancín (3, 4, 7) cuyos brazos forman parejas de acciones antagónicas paralelas sin extorsionarse, donde lo esencial es el balancín al que llamo de cruce (3, 7). Además de esto, se compone de un bombín hidráulico (13) de acción a dos direcciones fijado a placa base, dos brazos intermediarios en formación de tijera (12), cuatro brazos con cabezas osciladoras (10, 16) para la conexión del equipo con la acción o trabajo a realizar y rodamientos de agujas para el movimiento y ajuste de cada elemento. Este equipo ha sido ideado para mejorar el giro en los helicópteros de doble hélice en el grupo elevador. Aprovecha la actividad motriz para producir una variabilidad, haciendo que los actuales sistemas de giro queden superados.