baber/WOPTO huggingface dataset:
Patent UY-25874-A1 (UY)
Inventor: CUMMINGS MAXWELL DAVID
IPC: A61P19/02
Filed: 1999-12-22
Abstract: The present invention provides 4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.
Patent UY-28087-A1 (UY)
Title: Lamina revestida de adhesivo para administracion dermica de un inhibidor selectivo de cilooxigenasa-2
Inventor: EWING GARY D
IPC: A61K31/35
Filed: 2003-11-21
Abstract: Composición farmacéutica aplicable sobre un área de piel para tratamiento local y/o sistémico de trastorno mediado por COX-2 comprendiendo lámina de soporte adaptable flexiblemente al área de piel, teniendo dicha lámina superficies opuestas respectivamente distales y proximales a la piel al aplicarse y revestimiento sobre la superficie proximal de dicha lámina comprendiendo un adhesivo y un agente activo comprendiendo valdecoxib o uno de sus profármacos o una de sus sales, estando dicho agente en cantidad total terapéuticamente efectiva y disperso en matriz comprendiendo de nada a menos de una cantidad efectiva que solubiliza un agente activo en total de uno o más disolventes diferentes del adhesivo.
Patent UY-29300-A1 (UY)
Title: Compuestos quimicos
Inventor: LEE JOHN W
IPC: A61K31/44
Filed: 2005-12-22
Abstract: La invención se refiere a compuestos químicos, o sales farmacéuticamente aceptables de los mismos, de fórmula (I): que poseen actividad inhibidora de B-Raf y son concordantemente útiles para su actividad anticancerígena, y por ende en métodos de tratamiento del cuerpo humano o animal. La invención se refiere asimismo a procesos para la fabricación de dichos compuestos químicos, a composiciones farmacéuticas que los contienen y a su uso en la fabricación de medicamentos para utilizar en la producción de un efecto anticancerígeno en un animal de sangre caliente como el hombre.
Patent UY-30129-A1 (UY)
Title: Composiciones farmaceuticas
Inventor: FELIPE GASPAR
IPC: A61K31/403
Filed: 2007-02-02
Abstract: Formas y formulaciones de VX-950 amorfo y sus usos.
Patent UY-31647-A1 (UY)
Title: Forma de dosificación farmacéutica para la administración oral de inhibidor de tirosina quinasa
Inventor: HUMERICKHOUSE ROD A
IPC: A61K9/20
Filed: 2009-02-06
Abstract: Una forma de dosificación farmacéutica que comprende un producto de dispersión sólida de al menos un inhibidor de tirosina quinasa, al menos un polímero aceptable para su uso farmacéutico, y al menos un solubilizante aceptable para su uso farmacéutico.
Patent DZ-1815-A1 (DZ)
Inventor: COUDURIER ALAIN
IPC: A47J36/02
Filed: 1994-09-28
Granted: 2002-02-17
Abstract: The cooking vessel is made from a disc (3) of metal or light alloy. It comprises a bottom (1) intended to be laid on a hotplate, burner or the like. The bottom (1) comprises a plate (2) in a metal having different properties from those of the metal of the disc (3). This plate (2) is fully or partly let into the bottom (1) and its circumference may adjoin a groove (4). For improving the resistance to the deformation of the bottoms of cooking vessels. <IMAGE>
Patent DZ-1934-A1 (DZ)
IPC: C07D471/04
Filed: 1995-10-02
Granted: 2002-02-17
Abstract: Cycloalkano-indole derivs. and aza analogues of formula (I) and isomers and salts are new. R1-C=C-R2 = phenyl, pyridyl or a gp. of formula (a), all opt. substd. by 1-3 gps. R'; R8 = H or 1-4C alkyl; R3-C=C-R4 = phenyl, 4-8C cycloalkene or 4-8 membered oxocycloalkane (all opt. substd. by 1-3 gps. R'); R' = independently halo, CF3, COOH, OH, up to 6C alkoxy carbonyl, 1-6C alkoxy, or 1-6C alkyl (opt. substd. by OH or 1-4C alkoxy); R = H, 4-12C cycloalkyl or 1-12C alkyl; A = CO or CS; X = O, S or NR9; R9 = H or 1-6C alkyl (opt. substd. by OH or phenyl); R5 = phenyl or 5-8 membered, opt. unsatd. heterocyclic with 1-3 heteroatoms (S, N and/or O), (both opt. mono- to tri-substd. by NO2, COOH, halo, CN, 2-6C alkenyl, 1-6C alkoxy or alkyl (opt. substd. by OH, COOH, 1-6C alkoxy or up to 6C alkoxycarbonyl; and/or opt. mono- substd. by OR10 or NR11R12); R10 = H, 1-6C alkyl or 2-6C alkenyl; R11, R12 = H, phenyl, 1-6C alkyl, or up to 8C acyl (opt. subst. by NR13R14); R13, R14 = H or up to 8C acyl; R7 = H; R6 = H, COOH, 1-5 alkoxy, or 1-6C alkyl (opt. substd. by OH or OCOR15); or R6+R7 = O; R<15> = phenyl (opt. mono- to tri-substd., by halo, OH or 1-5C alkyl), or 1-22C alkyl or 2-22C alkenyl (both opt. substd. by OR16); R16 = H, benzyl, triphenylmethyl or up to 6C acyl. Also claimed are intermediates of formula (II).
Patent ES-177226-A1 (ES)
Title: Mejoras en o relativas a sistemas para la deteccion de obstaculos por medio de impulsos electromagneticos
IPC: G01S1/24
Filed: 1947-03-13
Abstract: Un sistema para la detección de obstáculos en el que impulsos que consisten de trenes de ondas electromagnéticas radiadas por un transmisor, son detectados por un receptor después de reflexión en un obstáculo, caracterizado en que se provee en medios para evitar que el receptor sea sobrecargado por los impulsos radiados recibidos directamente, por cuyos medios se evita que dicho receptor funcione un corto tiempo antes de la aparición de cualquiera de dichos impulsos radiados recibido directamente y se restablecen a condición de funcionamiento un corto tiempo después de la desaparición de los mismos.
Patent ES-184465-A1 (ES)
Title: UN PROCEDIMIENTO PARA LA OBTENCIoN SIN CALENTAMIENTO DE OBJETOS DE LáTEX
Filed: 1948-06-30
Abstract: Procedimiento para la obtención sin calentamiento de objetos de látex caracterizado por el hecho de que se somete el látex amoniacado fresco a la acción de fermentos o de substancias generadoras de fermentos durante un tiempo determinado; se agrega después una pequeña cantidad de óxido d cinc; se moldea y se deja que el látex se coagule en masa a la temperatura ambiente.
Patent ES-190981-A1 (ES)
Title: UN APARATO REGULADOR Y TONIFICADOR DEL SISTEMA NERVIOSO Y DE LA CIRCULACIoN SANGUiNEA POR MEDIO DE LA EXPULSIoN DE LOS CUERPOS
Filed: 1949-12-27
Abstract: Un aparato regulador y tonificador del sistema nervioso y circulación sanguínea por medio de la expulsión de los cuerpos caracterizado por estar constituido en su conjunto forma ésta en que habrá que aplicarlo para que surta eficaz efecto por seis dispositivos especiales cada uno de ellos aplicados a las diferentes partes del cuerpo afectadas por la dolencia todos ellos unidos por sus flexibles correspondientes para la toma de corriente en un solo enchufe cuya corriente se tomará de tierra.
Patent ES-194613-A1 (ES)
Title: ENGACHE SEMIAUTOMáTICO ARTICULADO LOCOMOTORA-TREN PARA REMOLQUES GUIADOS
IPC: B61G5/02
Filed: 1950-09-16
Abstract: Enganche semi-automático articulado locomotora tren para remolques guíados, destinados al acoplamiento de dos vehículos ferroviarios, el delantero con juegos de ruedas pivotadas en su parte inferior, y el siguiente del tipo de remolque, con un elemento de acoplamiento en la parte anterior caracterizados por comprender una viga prolongada transversalmente y en ella un elemento de acoplamiento adaptado para ajustarse con el elemento de acoplamiento del remolque; varillas de guía sostenidas por las partes extremas de la viga y preparadas para unirse de modo amovible al extremo anterior del remolque; tirantes de arrastre, convergentes hacia adelante, pivotados en la viga a distancias iguales del elemento de acoplamiento y preparados para conectarse pivotadamente al extremo posterior del vehículo tractor; los tirantes de arrastre citados están dispuestos de tal modo que sus ejes prolongados se cortan en el pivote del juego de ruedas posterior de la parte inferior del vehículo tractor; y soportesde suspensión ascendentes, fijos a los tirantes de arrastre y preparados para conectarse pivotadamente por sus extremos superiores al extremo posterior del vehículo tractor; dichos soportes de suspensión se prolongan en un plano vertical que pasa por los tirantes de arrastre con ellos asociados.
Patent ES-196292-A1 (ES)
Title: PROCEDIMIENTO PARA LA FABRICACIoN DE UNA MASA DE PLASTICIDAD PERMANENTE, SEGURA CONTRA INFLUENCIAS BIOLoGICAS Y QUiMICAS
Filed: 1951-01-26
Abstract: Procedimiento para la fabricación de una masa de plasticidad permanente de hidrocarburos o de sus mezclas con betún para utilización con o sin soportes para protección de corrosión protección de construcción y fines de aislamiento eléctrico caracterizado porque para la evitación de variaciones mecánicas y químicas de la masa misma o de los metales que hayan de protegerse condicionadas biológicamente se efectúan adiciones de materias bactericidas o insecticidas.
Patent ES-236719-A1 (ES)
Title: Method of making uranium-uranium monocarbide cermet
IPC: C22C32/00
Filed: 1957-07-23
Abstract: A cermet comprises a continuous matrix of uranium monocarbide containing particles or an intermeshing network of uranium, and is made by pressure shaping a powdered mixture of uranium and carbon (less than 50 atom of the mixture) and sintering in an inert atmosphere at a temperature sufficient to cause reaction between uranium and carbon but below the melting point of uranium. Preferably 0,3 to 4,5% of carbon is present, and the pressure shaping done at 650 DEG -750 DEG C.
Patent ES-270612-A1 (ES)
Title: Reconstitutable acid solubilized collagen
IPC: A22C13/00
Filed: 1961-09-19
Abstract: Reconstitutable solubilized collagen is prepared by extracting native collagen fibres in an aqueous solution of an organic acid at a temperature above 30 DEG C., but not over 70 DEG C., to solubilize the collagen in the fibres, the organic acid having a concentration from 0.01 to 1 molar and being selected from citric, glycolic, lactic, hydroxybutyric, benzilic and glycerol phosphoric acids, the extraction being carried out and completed in a period of less than four hours. The solubilized collagen extract may be admixed with native collagen fibres and the resulting mixture formed, e.g. as sheets or threads.ALSO:Collagen in forms such as sheets or threads may be obtained by re-aggregating, e.g. by heat coagulation, neutralization or salting out, a reconstitutable solubilized collagen prepared by extracting native collagen fibres in an aqueous solution of an organic acid at a temperature above 30 DEG C., but not over 70 DEG C., to solubilize the collagen in the fibres, the organic acid having a concentration from 0.01 to 1 molar and being selected from citric, glycolic, lactic, hydroxybutyric, benzilic and glycerol phosphoric acids, the extraction being carried out and completed in a period of less than four hours. Native collagen fibres may be added to the solubilized collagen fibres before forming, which is preferably effected by treatment with a half-saturated ammonium sulphate solution made basic with ammonium hydroxide.
Patent ES-293369-A1 (ES)
Title: Suction pipes for use in pumping liquid from containers
IPC: F04D9/00
Filed: 1963-10-30
Abstract: A suction pipe 5 has an entry port 9 above the level of the entry opening 11A of the pipe, the port being closed by a float valve 13 when the liquid level falls to a predetermined level. The flow from the port 9 through the duct 8 is arranged to merge smoothly with the flow in the reduced diameter bore 7, and radial vanes 17 are provided to resist the formation of vortices. The valve 13 is of O-section resiliently compressible material inflated with air. The pumping rate is reduced when the port 9 is closed to avoid excessive friction losses.
Patent ES-299121-A1 (ES)
Title: Electrostatic coating apparatus
IPC: B05C19/00
Filed: 1964-04-24
Abstract: Electrostatic coating apparatus comprises means for creating a floating cloud of finely divided coating substance at a coating station, means for presenting articles to be coated at said station, charging electrode means connected to a high electric potential relative to said articles and positioned to be closely approached by substantially all the particles in said cloud to charge the particles to a corresponding potential whereby particles from the cloud will be guided over lines of electric force towards said articles, and auxiliary ionizing electrode means connected to a potential substantially the same as the potential of the articles and positioned in spaced relation with said charging electrode and with the articles for controlling the spatial extent of the cloud by discharging the electrical charge of the particles entering into the ionizing zone of the auxiliary electrode means. The apparatus shown includes an insulated tank 1 having a perforated false bottom 2 which supports coating material 3. The space under false bottom 2 is connected by pipe 4 to a source of fluidizing gas under pressure and a vibrator unit 5 may be provided to assist in the fluidization of coating material 3. Means for electrically charging the particles in the fluidized cloud of coating material consists of an array of point electrodes or ionizers 6 connected to one terminal of high voltage source 7. In operation with source 7 in action and compressed air delivered through pipe 4 the coating material 3 is converted into a turbulent floating cloud and the electrodes 6 impart to substantially all the particles in the cloud a high electric potential. When articles to be coated (not shown) and at earth potential are support above the tank 1 said coating particles flow along the lines of force established and are deposited on the surface of the article to be coated. To control the spatial extent of the fluidized cloud of coating material control. electrodes 8 are fitted and in operation these electrodes act to discharge any cloud particles approaching them and thus prevent any undesirable spilling from the tank. The electrodes 8 may be in the form of point electrodes as shown or they can be in the form of wires running round the periphery of the tank. In a further embodiment the fluidized cloud is produced by an electrostatic spray-gun.
Patent ES-304494-A1 (ES)
Title: Improvements in or relating to apparatus for dispensing mixtures of liquids
IPC: B67D7/74
Filed: 1964-09-29
Abstract: Apparatus for dispensing petrol and oil mixture for two-stroke engines has a motor 1 driving a pump 2 to pump petrol up through an air separator 3 to a twopiston meter 4 from where petrol passes by a line 5 to a manually controlled nozzle 100 where it is mixed with a metered quantity of oil supplied through a line 6 by a pump 7 submerged in a tank 8 of lubricating oil, the meter 4 being coupled through a gear box 16 and chain 19 to pump 7 so that the latter is driven in synchronism with the meter 4 and a register 24 is coupled through gears 25, 26 with gear box 16. The stroke of the pistons in the meter 4 and pump 7 can be altered simultaneously in opposite senses so that the proportions of the mixture are adjusted but the total remains constant. An adjustment spindle of the meter 4 is coupled to a shaft 31 of gear box 16 and having a pinion 32 driven from a pinion 33 of a differential gear 37 through an idler 34 and an adjusting knob 41 is coupled to planet carrier 40 through gears 35, 43, the pump 7 being adjusted at the same time through bevel gears 50, 51, shaft 52 and worm wheel 53. Also allocated with knob 41 is a petrol oil ratio indicator 45. The dispensing nozzle 100 has a sight glass 112 through which the operator can see the lubricating oil rising through bleed holes 111 for mixture with the petrol flowing through the nozzle.
Patent ES-340591-A1 (ES)
Title: 1-(alpha-pyrryl)-2-amino ethanols
IPC: C07D207/33
Filed: 1967-05-16
Abstract: Novel compounds (includes salts with acids and alkyl halides) of the general formula wherein R is an alkyl, acyl, aryl or arylalkyl group which may be substituted by one or more halogen atoms, alkyl, hydroxy, alkoxy, -CF 3 , -NO 2 , -NH 2 or mono- or di-alkylamino radicals, R 3 is a hydrogen atom or an alkyl radical, R 1 is a hydrogen atom or an alkyl or cycloalkyl radical, and R 2 is a hydrogen atom or an alkyl or arylalkyl group, or R 1 and R 2 with the adjacent nitrogen atom represent a heterocyclic ring which may include a further hetero atom, are obtained by condensing an appropriate haloketone (i.e. a pyrrole substituted by -CO.CH.R 3 X at the 2-position and by R at the 1-position, X is halogen) with an amine, NHR 1 R 2 , and thereafter optionally hydrogenating a product wherein R 2 is a benzyl radical thereby replacing the benzyl radical by a hydrogen atom. Pharmaceutical preparations active on the central nervous system and suitable as analgesics, sedatives, analeptics and/or anti-convulsants contain as active ingredient the above novel compounds administration may be orally, subcutaneously or intravenously.
Patent ES-346188-A1 (ES)
Title: Container closure having pull-tab opening means
IPC: B65D47/36
Filed: 1967-10-18
Abstract: A container closure having a tear strip opener wherein the removable panel which is defined by a primary score line includes a secondary score line and a pull tab which is secured to the removable panel at the collar portion formed by the primary and secondary score lines. The pull tab extends transversely with respect to the primary and secondary score lines and a lifting of the free end of the tab will rupture the secondary score line and initiate rupture of the primary score line and twist the collar portion to facilitate subsequent rupture of the primary score line.
Patent ES-358850-A1 (ES)
Title: Fluid pressure control valve
IPC: F16K41/04
Filed: 1968-09-25
Abstract: A valve has a sealing member 17 movable relative to a bore 3 in a passageway through a housing 1 to control fluid flow therethrough. A sealing member 21 is mounted in an annular groove of the sealing member 17 and is urged by fluid pressure flowing through channel 25 or 26 against the surface of bore 3. A second more resilient sealing member 22 moves to seal the low pressure channel and assists in the radial force on the sealing member 21. The annular groove, sealing members and channels may be disposed in the housing to co-operate with the outer surface of the sealing member 17. The latter is moved axially in a bore 12 by a spindle 4 moved axially by the threaded connection with a hand wheel 5 and provided with teeth 8 co-operating with teeth 9 on the sealing member 17. Fluid pressure passes through passageways 18 and 15 to chamber 16 to balance the sealing member 17.
Patent ES-359042-A1 (ES)
Title: Stabilised Polymer Dispersions
IPC: C08F2/00
Filed: 1968-10-10
Abstract: Substrates, e.g. aluminium panels, are coated with a dispersion, in an organic liquid, of preformed synthetic organic polymer particles having attached thereto other preformed synthetic organic polymers soluble in the liquid, the soluble polymers being attached to the dispersed polymer particles by the interreaction of functional groups. Suitable dispersed polymers are polytetrafluoroethylene, tetrafluoroethylene/hexafluororpropylene, copolymers of acrylic and methacrylic acid and their amides, nitriles and esters, copolymers of styrene and vinyl toluene, polymers and copolymers of vinyl fluoride, vinylidene fluoride and other halogenated vinyl compounds, vinyl ester polymers, polyesters, polyethers, polyamides, polyimides, polyphenyls and polybenzamides. Suitable soluble polymers are copolymers of C 1 -C 8 alkyl acrylates and methacrylates with a monomer bearing functional groups e.g. 3-(#-methacryloxyethyl)-2, 2-spirocyclohexyloxyazolidone and amino ethyl vinyl ether.
Patent ES-362667-A1 (ES)
Title: Production of a wort concentrate or powder with the aid of enzyme preparations
IPC: C12C7/04
Filed: 1969-01-18
Abstract: A process for the manufacture of a brewers' wort in a concentrated or dried form comprises the steps of: (a) mixing a finely-divided starchcontaining material (barley, corn, rye, wheat, buckwheat or rice) with water at a temperature of from 30 to 50 C. to form a mash having a solids content of from 25 to 50% by weight, (b) adding cellulose, hemicellulase, protease and [alpha]-amylase (optionally, pectinase also) to the mash and, if necessary, adjusting the pH of the mash to between 4 and 7, (c) raising the temperature of the mash to from 50 to 60 C. so as to degrade and dissolve the cellulose, hemicellulose and proteins in the mash, (d) further raising the temperature of the mash to from 86 to 88 C. so as to liquefy the starch constituents of the mash, (e) cooling the mash to from 55 to 62 C., adding a saccharifying enzyme (malt flour, malt extract, fungal amylase or amyloglucosidase) and saccharifying the starch until the ratio of fermentable sugars to non-fermentable polysaccharides in the mash reaches a proportion suitable for the brewers' wort, (f) raising the temperature of the mash to from 85 to 115 C. so as to inactivate the saccharifying enzymes, (g) filtering the mash, and (h) concentrating or drying the filtrate, after addition of hop extract (if desired).
Patent ES-365694-A1 (ES)
Title: Thread guide for a rotary-hook-type sewing machine
IPC: D05B63/00
Filed: 1969-04-07
Abstract: In a lower free arm sewing machine of the rotary hook type the under thread 10 emerges from the bobbin case 12 by a slot 25 and out adjacent the needle plate through a hole 41 such that when the under thread is pulled it is downwardly cammed by and angled plate 39 to lie below the thread tensioner 27 which is urged towards the bobbin case by the spring 28. Once this is achieved the machine is turned by hand to pull the under thread up through the hole 6 in the needle plate by means of the needle thread.
Patent ES-366546-A1 (ES)
Title: Substituted phenylalkanoic acids
IPC: C07D207/327
Filed: 1969-04-28
Abstract: The invention comprises compounds of formula wherein Z is CH 2 or CO and R 1 is H, F or Cl, and their pharmaceutically acceptable salts. These compounds may be prepared by (1) reacting succinaldehyde or its derivative with a p-aminophenylbutyric or p-aminobenzoylpropionic acid (2) decarboxylating the corresponding malonic acid (3) hydrolysing the corresponding nitrile, alkyl ester or imido-ether (4) reacting an alkyl 2 - acetyl - 4 - [p - (1 - pyrryl) phenyl] butyrate with alkali metal hydroxide (for Z = CH 2 ) (5) reducing the compound where Z = CO to that where Z = CH 2 . Details are given for the preparation of the following starting materials and intermediates: 4 - (4 - acetamino - 3 - chlorophenyl) butyric acid ethyl 3-(p-aminophenyl) propionate RCO 2 Et, RCH 2 OH, RCH 2 Cl, RCH 2 OTs-(p), RCH(CO 2 Et) 2 and BCH(CO 2 H) 2 [where R = p - (1 - pyrryl) phenethyl] and R1CH(CO 2 Et) 2 , R1CH(CO 2 H) 2 and R1CH 2 CO 2 Et [where R1= 3 - chloro - 4 - (1 - pyrryl) phenethyl]. Also prepared is the 2,4-dinitrophenylhydrazone of 3-[p-(1-pyrryl) benzoyl] propionic acid. Therapeutic compositions for oral, rectal, local or parenteral administration comprise compounds of the above general formula, which have analgesic, antiphlogistic and antipyretic activity.