baber/WOPTO huggingface dataset:
Patent DE-69731226-T2 (DE)
Inventor: MADISON L
IPC: C12N15/00
Filed: 1997-06-10
Granted: 2006-03-09
Abstract: The invention provides substrate substraction libraries and methods of using substrate substraction libraries to identify highly selective substrates for enzymes which use peptides as substrates. In one embodiment, substrates for proteases such as t-PA and u-PA have been identified whose relative reactivities towards the two enzymes vary by a factor of more than 9000. The substrates identified by the present invention are useful for the construction of highly selective enzyme inhibitors.
Patent DE-69804943-T2 (DE)
Inventor: MASSA R
IPC: E21C35/00
Filed: 1998-01-26
Granted: 2002-11-14
Abstract: An excavation cutting toolholder retention system. The cutting toolholder retention system includes a cutting toolholder having a flange recess and a holder engagement surface and a support block having a toolholder bore into which the cutting toolholder is inserted and a block pin bore intersecting the toolholder bore, the block pin bore defining a block engagement surface which is inclined downwardly relative to the toolholder bore. The cutting toolholder retention system further includes a pin having a pin shaft, the pin shaft having a pin flange which engages the flange recess so as to limit translational movement of the pin shaft. The pin engages the block engagement surface and the holder engagement surface such that the pin may be moved to draw the cutting toolholder into the toolholder bore.
Patent DE-69806213-T2 (DE)
Inventor: SCOTT RICHARD CHARLES
IPC: H05B1/02
Filed: 1998-09-08
Granted: 2003-01-23
Abstract: Apparatus is described for controlling an electric heater incorporating at least one electric heating element (2A, 2B, 2C) and energised from a single voltage alternating current supply (8). The apparatus includes a control knob (15) for manually selecting any one of a predetermined number of power settings for the heater from the voltage supply (8), the power settings varying progressively between a minimum power setting and a maximum power setting. The apparatus further includes a controller (10) adapted and arranged to supply to the electric heater within a predetermined constant time interval in each power setting a first dissipated power level and a second dissipated power level. The first dissipated power level comprises a first selected proportion of half cycles in a predetermined number of half cycles of the voltage supply and the second dissipated power level comprises a second selected proportion of half cycles in a predetermined number of half cycles of the voltage supply. In a plurality of power settings the second selected proportion is different to the first selected proportion. There is no more than one change between the first and second dissipated power levels within the predetermined constant time interval. <IMAGE>
Patent DE-69812330-T2 (DE)
Inventor: SANTOS HELENA
IPC: A61K8/55
Filed: 1998-04-08
Granted: 2004-02-19
Abstract: The utilization of di-glycerol-phosphate as a stabiliser of enzymes and other cell components or cells, namely against heat, freezing, desiccation, lyophilization or repeated usage, is disclosed. Examples with rubredoxin, lactate dehydrogenase and alcohol dehydrogenase show that this compound is a better protecting agent than glycerol. This solute is produced by organic chemical synthesis readily and efficiently in three steps from commercially available glycerol in its racemic forms. The optically pure forms can be synthesised in four steps from commercially available D-mannitol. Di-glycerol-phosphate is obtained in a highly pure state without the necessity of complicated and tedious purification procedures.
Patent DE-69813749-T2 (DE)
Inventor: PEZRON ERWOAN
IPC: C08K3/22
Filed: 1998-12-22
Granted: 2004-04-29
Abstract: Polyester resin-based molding compositions, and methods for making and using the same, are described which have an improved maturation profile upon addition of a thickening agent. The improved maturation profile results from the presence of at least one multivalent metal salt of a non-fatty acid or anhydride in the molding composition added in accordance with the invention.
Patent DE-69814191-T2 (DE)
Inventor: SAWA SHIROU
IPC: A61K31/535
Filed: 1998-02-03
Granted: 2004-04-01
Abstract: A method for solubilizing a pyridonecarboxylic acid or a pharmacologically acceptable salt thereof, which comprises adding an arylcarboxylic acid of the formula (I): L<1> -R<1> COOH wherein L<1> is an optionally substituted heterocyclic group or aryl group having not more than 14 carbon atoms, and R<1> is an optionally substituted alkyl group having not more than 4 carbon atoms or a single bond, to the pyridonecarboxylic acid or the pharmacologically acceptable salt thereof, a solubilizer thereof and an aqueous solution containing a solubilized pyridonecarboxylic acid. According to the solubilization method of the present invention, the solubility of pyridonecarboxylic acid compounds and salts thereof at near physiological pH can be increased, thereby making the production of an aqueous solution to be used as an eye drop, nasal drop, ear drop and the like possible.
Patent DE-69814682-T2 (DE)
Inventor: STJERNA NILSERIC
IPC: A47C23/053
Filed: 1998-12-11
Granted: 2004-04-08
Abstract: A spring mattress including a number of interconnected coil spring elements, and a method of manufacturing the mattress. The spring mattress includes the coil spring elements that are interconnected by surface elements, such as strip pieces made from textile or plastic material and extending at least in one plane that is essentially in parallel with a plane of the mattress, with the strip pieces extending between and being attached to pairs of neighboring spring elements, thus interconnecting the spring elements.
Patent DE-69815847-T2 (DE)
Inventor: ERRUZ GRIMAL JOSE
IPC: B66B7/12
Filed: 1998-05-05
Granted: 2004-05-13
Abstract: Device for collecting oil from elevator guide rails useful for installation on T-rails along which moves an elevator, characterised in that it comprises a rectangular prism-shaped container (3) with an open top and provided in the centre as seen from its sides with an indentation (6), means for anchoring container (3) to core (4) of a T-rail (2) of the elevator, and means for adapting container (3) to different lengths of core (4) for a given core width of different trails (2) <IMAGE>
Patent DE-69816284-T2 (DE)
Inventor: ITOH KATSUMI
IPC: C07D233/00
Filed: 1998-03-30
Granted: 2004-05-27
Abstract: A quaternized nitrogen-containing imidazol-1-yl or 1,2,4-triazol-1-yl compound wherein one of the nitrogen atoms constituting an azole ring is quaternized with a substituent capable of being eliminated in vivo and the substituent can be eliminated in vivo to be converted into an antifungal azole compound, has an improved solubility in water, can advantageously be applied to injection, has an improved internal absorption and can be expected to have a good effect for the treatment or prevention of disease.
Patent DE-69817944-T2 (DE)
Inventor: TAMBURINI MASSIMO
IPC: B62K19/32
Filed: 1998-07-24
Granted: 2004-07-15
Abstract: A conical shaped locking device for a bearing holder part (13) of a steeering unit of a motorcycle or similar of a type including handlebars connected to a steering axis (4) located into such a part inserted into a sleeve part (3) of a vehicle chassis (1), such handlebars and steering axis (4) being parts of an assembly unit of steering unit and suspensions connected to a front wheel of a motorcycle . Wedge shaped detachable means are provided capable to cooperate with at least one end part (3A) of sleeve (3) and a related end part (17) of bearing holder part, these means cooperating also with at least a portion of the surfaces of these end parts (3A,17) and being attachable to at least one of these last ones, said attachment by locking this bearing holder part (13) on said sleeve (3). <IMAGE>
Patent DE-69823874-T2 (DE)
Inventor: LYKKEGAARD UFFE
IPC: B65G17/12
Filed: 1998-12-30
Granted: 2005-05-25
Abstract: A conveyor transports lightweight articles with a high degree of adaptability to the space it can occupy and the path along which the conveyor units can travel. The track of the conveyor has curving track sections connecting straight track sections having opposite transport directions and the individual conveyor unit comprises guide members that engage with stationary guides to prevent the article supporting member of the unit from tilting when passing straight as well as curving track sections. The article supporting members of the units are arranged between the main track and the stationary guides when the units are moving along the curving main track section. In particular, each unit may have first and second guiding members to prevent tilting of the article supporting member at curving and straight track sections, respectively, and both guiding members co-operate with their respective guides over a certain distance when the unit enters and leaves a curving track section.
Patent DE-69828911-T2 (DE)
Inventor: BLAZEK DALIBOR
IPC: A45D29/04
Filed: 1998-07-09
Granted: 2006-01-19
Abstract: A file (1), particularly a nail file is formed of a body of glass (3) having a roughened abrading surface (2). The roughness may have an average depth, peak to valley in the range of 10 to 100 micrometers. The file may be made of flat, pressed or hardened glass. The file can have a variety of geometrical shapes and cross sections. The roughening can be achieved by etching with a HF solution.
Patent DE-69831974-T2 (DE)
Inventor: YLOENEN TATU
IPC: H04L12/66
Filed: 1998-12-30
Granted: 2006-06-08
Abstract: For achieving packet authentication according to an applicable security policy between a sending node (903) and a receiving node (902) in a network, the following steps are taken:the transformations occurring to a packet en route between the sending node and the receiving node are discovered dynamically (1003, 1004),the discovered transformations are checked (1004) to be acceptable based on the applicable security policy, andthe dynamically discovered, acceptable transformations are compensated for (1004, 1006) before authenticating packets transmitted from the sending node to the receiving node.
Patent DE-69833436-T2 (DE)
Inventor: LEE CHANGHUN
IPC: H01J37/32
Filed: 1998-06-24
Granted: 2006-10-26
Abstract: A plasma processing system configured for use in processing a substrate after metal etching. The substrate includes a layer of photoresist disposed thereon. The plasma processing system includes a plasma generating region and a baffle plate disposed between the plasma generating region and the substrate. The baffle plate includes a central blocked portion disposed in a center region of the baffle plate. The baffle plate further includes an annular porous portion surrounding the central blocked portion. The annular porous portion includes a plurality of through holes configured for permitting a H2O plasma generated in the plasma generating region to pass through the holes to reach a surface of the substrate. The plasma processing system also includes a chuck disposed below the baffle plate to support the substrate during the processing.
Patent DE-69836596-T2 (DE)
Inventor: HEIDMANN KURT
IPC: A47C1/024
Filed: 1998-10-19
Granted: 2007-09-20
Abstract: A chair (20) is provided having a base assembly (21) including a base frame, a back frame (30) pivoted to the base frame for movement between upright and reclined positions, and a seat (24) slidably supported on the base frame and pivoted to the back frame so that the seat moves forwardly and its rear moves forwardly and downwardly with the back frame upon recline. A flexible back is connected to the back frame at top and bottom locations and is provided with lumbar adjustment for improved lumbar force/support and shape. A seat is provided with seat depth adjustment and with active and passive thigh flex support. A novel energy mechanism (27) is provided that includes a transverse spring (28), a lever (54) and a movement arm shift adjuster (29) for adjusting the spring tension on the back frame. The moment arm shift adjuster is readily adjustable and includes an overtorque device to prevent damage to components of the energy mechanism. <IMAGE>
Patent DE-69901912-T2 (DE)
Inventor: NOVARESE FABIO
IPC: H05B41/392
Filed: 1999-10-08
Granted: 2002-10-31
Abstract: Electronic system for generating and controlling light effects on projectors utilizing arc lamps, composed of an electronic power unit provided with a transformer fed via transistors, the secondary circuit of the transformer being connected to the feed terminals of the lamp, within the secondary circuit of the transformer there being connected a component for withdrawing a proportion of the instantaneous current circulating through the secondary circuit to produce an electrical signal which is made available to a control block which also receives an electrical reference signal generated by a pulse generator, the control block being arranged to compare the two electrical signals and to set the transistors to a conducting or inhibiting state depending on the result of the comparison, the amplitude and frequency of the electrical reference signal being adjustable by the operator.
Patent DE-69904652-T2 (DE)
Inventor: INABA TAKASHI
IPC: C07D317/28
Filed: 1999-01-15
Granted: 2003-10-23
Abstract: A method for producing an optically active amino alcohol compound of the formula Ä3Ü, an enantiomer thereof or a salt thereof, comprising reacting a mesoepoxide compound of the formula Ä1Ü with a compound of the formula Ä2Ü in the presence of a mixed catalyst comprising a Lewis acid and a proton donor: <CHEM> wherein R<1>, R<2> and R<3> are each H, an optionally substituted lower alkyl, and the like, or R<1> and R<1> or R<2> and R<3> may form an optionally substituted ring; and R<4> and R<5> are each H, an optionally substituted lower alkyl, and the like, or R<4> and R<5> may form an optionally substituted ring together with the adjacent N, or an imide group or azide group together with the adjacent N, and R<6> is H or a silyl group. The present invention enables stereoselective production of a desired intermediate compound, which is an HIV protease inhibitor, extremely efficiently as compared to conventional methods. The method of the present invention is a very useful method which can be used not only for the production of said intermediate compound but also for the production of various other compounds.
Patent DE-69937650-T2 (DE)
Inventor: SETH PAWAN
IPC: A61K9/32
Filed: 1999-10-07
Granted: 2008-07-17
Abstract: The invention provides a controlled release tablet, free of stabilizer and free of pore-forming agent comprising: (i) a core consisting essentially of bupropion hydrochloride, a binder and a lubricant; and (ii) a coating consisting essentially of a water-insoluble, water-permeable film-forming polymer, a plasticizer and a water-soluble polymer.
Patent DE-69937757-T2 (DE)
Inventor: VAN DEN BERG KAREL
IPC: A23K1/16
Filed: 1999-10-01
Granted: 2008-11-27
Abstract: The invention relates to an implement for automatically feeding animals, such as calves or cows, comprising  means for attuning the amount of feed to the nutritive need of the individual animal, means for supplying the feed to the individual animal, characterized in that the implement comprises a milking means for yielding the milk or mother's milk, and means for supplying the milk or mother's milk automatically, and directly from the milking machine to the individual animal or after having been stored in a first or further storage means (12,13), said means comprising a transport system for liquids, a metering device and a feeding station for animals which is coupled to a milking machine.
Patent DE-69937965-T2 (DE)
Inventor: CROOKE HELEN RACHEL
IPC: A61P31/04
Filed: 1999-11-09
Granted: 2009-01-08
Abstract: The present invention is based on the identification of a series of virulence genes in  E. coli  K1, the products of which may be implicated in the pathogenicity of the organism. The identification of the genes allows them, or their expressed products, to be used in a number of ways to treat infection.
Patent HU-E030418-T2 (HU)
Title: Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
Inventor: RODGERS JAMES D
IPC: A61P37/00
Filed: 2006-12-12
Abstract: The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines (I) and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
Patent HU-E027411-T2 (HU)
Title: Modulation of apolipoprotein C-III expression
Inventor: CROOKE ROSANNE M
IPC: A61K38/00
Filed: 2004-04-15
Abstract: Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided.
Patent MD-3707133-T2 (MD)
Inventor: HENRY KENNETH JAMES JR
IPC: C07D403/14
Filed: 2018-10-30
Abstract: Invenţia furnizează compuşi inhibitori de BTK, săruri acceptabile farmaceutic, compoziţii farmaceutice ale acestora, şi metode pentru utilizarea acestor compuşi, săruri, sau compoziţii pentru a atrata bolile autoimune cum ar fi artrita reumatoidă.
Patent MD-3969670-T2 (MD)
Inventor: WARNER JEREMY DAVID
IPC: E02F3/92
Filed: 2020-10-27
Abstract: O metodă de dragare care cuprinde suspendarea aparatului de dragare 200 de un vehicul 360. Aparatul de agitare a sedimentului care cuprinde un şasiu 210, şi montat pe şasiu sunt un extractor, aparat de agitare a sedimentului şi respectivele pompe 220, 230. Aparatul de dragare 200 este dispus deasupra, dar nu în contact cu o albie de apă 340 care urmează să fie dragată de sediment 350. Sedimentul 350 este agitat apoi extras cu extractorul. Aparatul de dragare 200 este deplasat în apă şi sedimentul extras 400 este depozitat sub apă şi deasupra aparatului de dragare 200, astfel încât sedimentul 400 este transportat şi depozitat departe de o zonă care este dragată de mişcarea naturală a apei.Aparatul şi utilizarea aparatului este de asemenea descrisă.
Patent TR-200102560-T2 (TR)
Inventor: STILZ HANS ULRICH
IPC: A61K38/08
Filed: 2000-02-19
Abstract: Object of the present invention are low molecular weight peptide derivatives which are able to act as inhibitors of the interaction between laminin and nidogen (laminin/nidogen interaction), a process for their preparation, pharmaceutical compositions prepared therefrom and their use for preparing pharmaceuticals and for identifying inhibitors of the laminin/nidogen interaction.
Patent TR-200200985-T2 (TR)
Title: Pürin türevleri
Inventor: MONAGHAN SANDRA MARINA
IPC: C07H19/167
Filed: 2000-10-06
Abstract: Mevcut bulus formül (I)'e göre olan bilesikler ve bunlarin farmakolojik olarak kabul edilebilir tuzlari ve solvatlari, bunlarin hazirlanmasi için usuller, bunlarin hazirlanmasinda kullanilan ara ürünler ve bu tip bilesikleri içeren bilesimler ve bu tip bilesiklerin adenosin A2a reseptör olarak kullanimi ile ilgilidir.
Patent TR-200201669-T2 (TR)
Title: MTP inhibitörleri olarak ikameli piperazin türevleri
Inventor: HECKEL ARMIN
IPC: C07D209/18
Filed: 2000-12-16
Abstract: Isbu bulus genel formül (I)'in, içlerindeki Ra ila Rc'nin, Ya'nin, Yb'nin, X'in ve n' nin (1) sayili istemdeki gibi tanimlanmis oldugu ikameli piperazin türevleri, onlarin izomerleri ve tuzlari, özellikle de, mikrosomal trigliserit-transferprotein'im (MTP) degerli inhibitörlerini sunan fizyolojik olarak hazmedilebilen tuzlari, bu bilesimleri ihtiva eden ilaç maddeleri ve onlarin kullanimi ve ayrica imal edilmeleri ile ilgilidir.
Patent DE-602004003538-T2 (DE)
Inventor: SIMON BACARDIT JUAN
IPC: B60T13/575
Filed: 2004-10-05
Granted: 2007-09-20
Abstract: The servomotor has a push rod (32) with a thermal dilatation unit (48) mounted between a stopper (50) integrated to the rod, and a front radial side (42) on a reaction disk (30). An axial gap is provided which determines a point of changing of power assistance ratio. The dilatation unit (48) provides an effect opposite to that of the disk on the axial gap at the time of temperature variations.
Patent DE-602004011981-T2 (DE)
Inventor: JANSSON OLOF
IPC: A61M1/28
Filed: 2004-10-13
Granted: 2009-03-05
Abstract: The invention concerns a device and a method for a peritoneal dialysis treatment in several cycles. A cycler (1) controlled by a processor (31) fills the abdominal cavity with dialysis fluid, and drains the abdominal cavity. A sensor (37) senses a variable related to the draining of the dialysis fluid. The draining is interrupted when the variable reaches a breakpoint at which the variable is radically changed, thereby leaving the residual volume.
Patent DE-602005002015-T2 (DE)
Inventor: KADAH HASSAN B
IPC: H01H9/56
Filed: 2005-12-21
Granted: 2008-05-15
Abstract: A relay situated in series between an AC line source and an AC load has a core conductor (18) connected with the fixed N.O. contact (28), so that load current flows axially through the core of the actuator coil (14). Alternatively, the fixed N.C. contact may be connected with the core conductor. A plate armature (224) with leaf springs (222) can achieve linear axial action. A sensor (38) connected to leads of a winding of the actuator coil picks up a an induced voltage that is representative of the current supplied to the load. This provides a simple arrangement for monitoring for current level and can be used for measuring power factor or ¦ at the load device. In a three phase embodiment, phase imbalance can be detected.
Patent DE-602005002344-T2 (DE)
Inventor: LIN YUEH-HUI
IPC: C12Q1/00
Filed: 2005-03-03
Granted: 2008-06-12
Abstract: The present invention provides a method for determining the concentration of an analyte in a test sample, comprising the following steps: (a) assembling an amperometric biosensor, which comprises at least an electrode system and an electric mediator for redox, and applying a predetermined potential to the electrode system; (b) applying a test sample to the biosensor and immediately gradually lowering the predetermined potential to a value unable to drive the electrochemical redox of the electric mediator; (c) after a sufficient reaction time, applying a second potential to the electrode system of the biosensor to drive the electrochemical redox of the electric mediator; and (d) measuring the electrochemical current of the electrode system and determining the concentration of the analyte.
Patent DE-602005003231-T2 (DE)
Inventor: HORS DANIEL
IPC: G09B9/28
Filed: 2005-06-27
Granted: 2008-09-04
Abstract: A device for remotely controlling the control surfaces of an aircraft, the device comprising: an actuator member pivotable about an axis and entraining a rotary shaft; a stationary finger parallel to the shaft and supported at a radial distance from the shaft; a moving finger secured to the shaft and supported at a radial distance therefrom, both fingers being parallel to the shaft; a first slab supported at a radial distance from the shaft beside the two fingers on one side thereof and suitable for turning about the axis of the shaft; a second slab supported at a radial distance from the shaft beside the two fingers on their side opposite from the first slab, and suitable for turning about the axis of the shaft; a third slab supported at a radial distance from the shaft beside the second slab at an angular distance therefrom and suitable for turning about the axis of the shaft; a first spring between the first and second slabs; and a second spring between the first and third slabs.