Patent SG-11201909265Q-A (SG)
Title: Plasmodium sporozoite npdp peptides as vaccine and target novel malaria vaccines and antibodies binding to
Inventor: LANZAVECCHIA ANTONIO
IPC: A61P33/06
Filed: 2018-04-19
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date omit VIII °nolo VIII 11110 101111101111111 (10) International Publication Number WO 2018/193063 A2 25 October 2018 (25.10.2018) WIP0 I PCT (51) International Patent Classification: C07K 16/20 (2006.01) A61K 39/015 (2006.01) Published: A61K 38/03 (2006.01) A61P 33/06 (2006.01) — without international search report and to be republished upon receipt of that report (Rule 48.2(g)) (21) International Application Number: — with sequence listing part of description (Rule 5.2(a)) PCT/EP2018/060113 (22) International Filing Date: 19 April 2018 (19.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/487,266 19 April 2017 (19.04.2017) US (71) Applicant: INSTITUTE FOR RESEARCH IN BIOMEDICINE [CH/CH]; Via Vincenzo Vela 6, 6500 Bellinzona (CH). (72) Inventors: LANZAVECCHIA, Antonio; Via ai Ronchi 6, 6948 Porza (CH). TAN, Joshua Hoong Yu; 4, Jalan Sungai Beranang 32/56, Bukit Rimau, Shah Alam, 40460 (MY). DAUBENBERGER, Claudia; Am Lerchenbuck 17, 79379 Millheim (DE). SACK, Brandon; 1156 Alki Ave SW, Apt 103, Seattle, Washington 98109 (US). (74) Agent: VON STOSCH, Andreas et al.; Prinzregentenstr. 22, 80538 Miinchen (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). O (54) Title: NOVEL MALARIA VACCINES AND ANTIBODIES BINDING TO PLASMODIUM SPOROZOITES (57) : The present invention provides a fragment of piasmodium circumsporozoite protein according to SEQ ID NO: 1, for 00 example for use in a malaria vaccine. The present invention also provides nucleic acids encoding a fragment of piasmodium circum- sporozoite protein according to SEQ ID NO: 1, compositions comprising a fragment of piasmodium circumsporozoite protein according to SEQ ID NO: 1 and antibodies binding to a fragment of piasmodium circumsporozoite protein according to SEQ ID NO: 1. The O antibodies according to the present invention bind specifically to P. falciparum sporozoites and may be used in the treatment and/or C prevention of malaria.