baber/WOPTO huggingface dataset:
Patent DO-P2019000280-A (DO)
Title: Formulaciones estables de anticuerpos contra el receptor de muerte programada 1 (pd-1) y métodos para su uso
Inventor: MANOJ K SHARMA
IPC: C07K16/18
Filed: 2019-11-01
Abstract: La invención se refiere a formulaciones estables de anticuerpos contra el receptor de muerte programada humano PD-1, o fragmentos de fijación al antígeno de este. En algunas formas de realización, las formulaciones de la invención comprenden entre 5 y 200 mg/ml de anticuerpo anti-PD-1, o un fragmento de fijación al antígeno de este. La invención además proporciona métodos para tratar distintos tipos de cáncer con formulaciones estables de la invención. En algunas formas de realización de los métodos de la invención, las formulaciones se administran a un sujeto mediante administración intravenosa o subcutánea.
Patent DO-P2021000196-A (DO)
Title: Combinaciones fungicidas
Inventor: CARLOS EDUARDO FABRI
IPC: A01P3/00
Filed: 2021-09-21
Abstract: Una combinación que comprende un fungicida de contacto multisitio, un fungicida inhibidor de succinato deshidrogenasa y un segundo fungicida sistémico y un método que utiliza el mismo.
Patent EC-SP10010622-A (EC)
Title: Composición farmacéutica que comprende una sal de estroncio, vitamina d y una ciclodextrina
Inventor: PEAN JEAN-MANUEL
IPC: A61K33/24
Filed: 2010-11-22
Abstract: Composición farmacéutica que comprende una sal de estroncio, vitamina D y una ciclodextrina.
Patent EC-SP11010940-A (EC)
Title: Microemulsionantes y métodos para hacer y utilizar los mismos
Inventor: VAN ZANTEN RYAN
IPC: C09K23/00
Filed: 2011-04-01
Abstract: Un método que comprende el contactar un surfactante zwitteriónico, cosurfactante y agua para formar un microemulsionante y el contactar el microemulsionante con un fluido oleaginoso bajo condiciones de cizallamiento bajas para formar una microemulsión. Un método que comprende la introducción de un primer fluido de mantenimiento del pozo que comprende por lo menos un fluido oleaginoso dentro de un pozo, donde el primer fluido de mantenimiento de pozo forma sólidos humedecidos con petróleo y/o superficies humedecidas con petróleo en el pozo y que contiene los sólidos humedecidos con petróleo y/o superficies humedecidas con petróleo en el pozo con un segundo fluido de mantenimiento de pozo que comprende un surfactante zwitteriónico, un cosurfactante y una salmuera para formar una microemulsión.
Patent EC-SP11011202-A (EC)
Title: Método para modificar la volatilidad del petróleo antes de la adición de etanol
Inventor: MATTINGLY LARRY D
IPC: C10L1/18
Filed: 2011-07-13
Abstract: La invención se relaciona a sistemas y métodos para modificar la volatilidad de petróleo antes de la adición de etanol. Los métodos pueden incluir (a) proporcionar (i) un suministro de gasolina, (ii) un estándar de etanol y (iii) un suministro de butano; (b) analizar la volatilidad de una muestra formada al mezcla la gasolina y el estándar de etanol; (c) calcular de la volatilidad una relación de butano que puede ser mezclado en la muestra sin causar que la muestra pase en uno o más límites de volatilidad fijados; (d) mezclar el butano del suministro de butano con gasolina del suministro de gasolina en o debajo de la relación calculada en la etapa (c).
Patent EC-SP13012543-A (EC)
Title: Análogos de buprenorfina
Inventor: KYLE DONALD J
IPC: C07D489/12
Filed: 2013-04-05
Abstract: La presente invención está dirigida a los compuestos análogos de Buprenorfina de la Fórmula I, Fórmula IA o Fórmula IB que se enseñan a continuación, en los cuales R1, R2, R8, R3a, R3b, G, X, Z e Y son como se han definido en la descripción. Los compuestos de la invención son útiles para tratar el dolor, la constipación, y otras condiciones moduladas por la actividad de los receptores opioide y ORL-1.
Patent EC-SP13013007-A (EC)
Title: Uso de 2,3-dihidroimidazo[1,2-c]quinazolinas sustituidas
Inventor: LIU NINGSHU
IPC: G01N33/48
Filed: 2013-11-04
Abstract: - Uso de un compuesto de 2,3-dihidroimidazo[1,2-c]quinazolina, o de una composición farmacéutica que contiene el mismo, como agente activo único, o de una combinación de a) dicho compuesto o una composición farmacéutica que contiene dicho compuesto y b) uno o más agentes activos adicionales, para la preparación de un medicamento para el tratamiento o profilaxis de cáncer;- combinaciones de a) dicho compuesto y b) uno o más agentes activos adicionales;- una composición farmacéutica que comprende dicho compuesto como agente activo único para el tratamiento de cáncer de mama;- una composición farmacéutica que comprende una combinación de a) dicho compuesto y b) uno o más agentes activos adicionales;- uso de biomarcadores involucrados en la modificación de la expresión de Bcl, expresión y/o activación de la familia HER, señalización por PIK3CA y/o pérdida de PTEN para predecir la sensibilidad y/o resistencia de un paciente con cáncer a dicho compuesto y proveer una combinación sinérgica basada en la razón, como se define en la presente, para incrementar la sensibilidad y/o para superar la resistencia; y- un método para determinar el nivel de un componente de uno o más de expresión de Bcl, expresión y/o activación de la familia HER, señalización por PIK3CA y/o pérdida de PTEN.
Patent GB-189700661-A (GB)
Title: Improvements in Self Detaching Hooks for Winding Purposes.
Inventor: HUMBLE STEPHEN
Filed: 1897-01-09
Granted: 1897-03-13
Abstract: 661. Humble, S. Jan. 9. Hooks, self - de - taching, for winding purposes. The hook is formed of pivoted catches A working within side plates E, E in the usual way. The catches A are made solid with h strengthening- plates B at the neck, which overlap between the side plates as shown in plan in Fig. 4.
Patent GB-189706174-A (GB)
Title: Improvements in Propelling Mechanism for Cycles.
Inventor: BEEKMAN GERARD
Filed: 1897-03-09
Granted: 1897-11-27
Abstract: 6174. Beekman, G. March 9. Driving-mechanism : clutches. - Relates to the invention described in Specifications No. 23,619, A.D. 1895, and No. 2513, A.D. 1896, wherein the grip of the clutch is made more efficient. The Figures show a form suitable for a bicycle. The sprocket - wheel A is mounted upon a hollow shaft D rotating in ball bearings in the bottom bracket E. The axle B is journalled in ball bearings 5, and the cup piece 6 is mounted in elastic bushings 7 within the shaft D. There are two grip members G, H, the inner grip member G being secured to the axle B and the outer member H forming a ring having sockets 11, engaging with corresponding shoulders 12 on the crank C. The flanges 3 of the shaft D and the grip members are separated by washers 4 of raw hide or leather. The flanges 3 and the washers 4 may be corrugated to ensure a grip. The pedal crank C is pivoted on a fulcrum stud 8 in the plate or crank support 9 fixed to the axle. A spring 10 is mounted on a projection of the plate 9 and bears on the ring H, forcing the socket 11 to press on the shoulders 12 with sufficient force to prevent the mere weight of the rider's legs from forcing the crank out of the radial line. By pressing on the pedals, the grip members G and H are brought together so as to bind upon the flange 3, and thereby cause it to rotate with the cranks. A modification is described, in which the shaft B is journalled on a fixed axis and the inner grip member is omitted, there being two external grip members in lieu of one. The mere weight of the rider's legs will allow the driven part to revolve freely while the pedals are stationary or rotating at a different rate. When force is exerted, the action of the grip members affords a powerful hold either for propulsion or for brake action as desired.
Patent GB-189709598-A (GB)
Title: Improvements in Machines for Spreading India-rubber or other Plastic Materials or Cement upon Fabrics.
Inventor: WALMSLEY ROBERT
Filed: 1897-04-15
Granted: 1898-03-05
Abstract: 9598. Walmsley, R. April 15. Coated fabrics.- Relates to a machine for spreading india-rubber or like plastic material. Two sets of spreading-apparatus are placed at each end of the machine with intermediate steam - chests l. Each set of apparatus consists of a fabric roller k, spreading-roller j, nipping-roller f, and spreading-gauge g. Suitable driving-mechanism is provided, with clutches for disconnecting each set of apparatus separately. The gauges are adjusted by screws z. The nipping- rollers f are journalled in weighted levers f<3> and are raised by cams to put them out of action.
Patent GB-189712549-A (GB)
Title: Improvements in Plates for Accumulators.
Inventor: MAJERT WILHELM
Filed: 1897-05-20
Granted: 1897-08-14
Abstract: 12,549. Majert, W. May 20. Secondary batteries. -Plates or electrodes are built up of bars or ribbons b, which are corrugated, as shown, for the purpose of more securely holding the paste. The projecting portions of ribbed plates may be treated in the same way, and polygonal or other gratings may be corrugated at the edges.
Patent GB-189719429-A (GB)
Title: Improvements in the Manufacture of Resinous Soap and Apparatus Therefor.
Inventor: ARLEDTER FRITZ
Filed: 1897-08-23
Granted: 1897-10-09
Abstract: 19,429. Arledter, F. Aug. 23. Mixing soaps.- Relates to apparatus for use in making resin soap. The boiler a is heated by means of a steam jacket b. The soap mass is stirred by the stirrer c, and the froth as it rises is broken up by means of the slotted plates x and the two pairs of cutting-knives v, w, which rotate in opposite directions. The height of the knives v, w and slotted plates x can be adjusted.
Patent GB-189719654-A (GB)
Title: Improvements in Paper Pencil Sheaths or Sticks.
Inventor: BOLLE CARL
Filed: 1897-08-26
Granted: 1898-02-12
Abstract: 19,654. BollÚ, C., [Bremer, H.]. Aug. 26. Pencils.-Relates to pencils sheathed in paper which is torn off in strips as the pencil is worn away. The sheath is provided with large orifices B, and after it is wound on the pencil, an adhesive substance is allowed to soak through these orifices to secure the layers together. Deep notches bare then made between the orifices B to facilitate the severance of the strips a.
Patent GB-189721669-A (GB)
Title: Improvements in Insulators for Telegraph and like Wires.
Inventor: ASHBY GEORGE
Filed: 1897-09-22
Granted: 1898-08-13
Abstract: 21,669. Ashby, G. Sept. 22. Insulators.-An insulator for telegraphic and other purposes consists of a glass-or other disc 5 held between shouldered wooden discs 10 in the arms of a fork 4 by a bolt 15. The fork is secured by a screw 3 to the crossarm 1 or other object. The wire 8 and binding wire 9 are held in a groove 7 in the insulator 5. One side of the fork 4 is extended at 6 to form a temporary catch for the wire. When attached to a side wall, the fork is replaced by a central screw bolt.
Patent GB-189724537-A (GB)
Title: Distributor for Agricultural Purposes.
Inventor: SARGEANT THOMAS CHARLES
Filed: 1897-10-23
Granted: 1898-08-20
Abstract: 24,537. Sargeant, T. C. Oct. 23. Manuring and fertilizing.-Relates to a distributor especially adapted for scattering sticky manures, such as superphosphates. Figs. 5 and 6 show the machine in section, with the travelling wheels, which are mounted on stub axles a, removed. The machine consists of a cylinder or shield d cut away at e for the discharge of the manure, a scattering-wheel c mounted on the shaft a<1>, and a movable hopper j. The hopper is pivoted on a bar i supported at each side of the machine in a movable frame h, pivoted on the shaft a<1>, and provided with a segmental slot through which the axle a projects. This arrangement allows the frames h, and with them the hopper j, to be turned into the position shown in Fig. 6, for the hopper to be filled. The hopper is held by means of stops on the hopper engaging stops k on the frames h. In the position shown in Fig. 6, a portion of the shield d forms one side of the hopper, and causes what afterwards becomes the upper surface of the manure to have the curvature of the distributing-wheel, so that the delivery of the manure is uniform. The free end of the hopper is suspended by a chain q which is wound upon a drum r on a shaft r<1>. The shaft r<1> is gradually rotated as the machine moves forward, and thus winds up the chain q and raises the hopper j to feed the manure to the wheel c. The mechanism for rotating the wheel c and the shaft r<1> forms no part of the invention. The Specification describes two forms of such gearing which are not shown in the Figures.
Patent GB-189725411-A (GB)
Title: Improvements in Vapour Burners.
Inventor: SMITH HARPER FORREST
Filed: 1897-11-02
Granted: 1897-12-11
Abstract: 25,411. Smith, H. F. Nov. 2. Vapour burners. - The hydrocarbon in the supply pipe A is vaporized by a secondary flame from the tube H, to which air is admitted by the opening N, and which communicates by a channel G with the burner tip F. The vapour, controlled by the valve D, enters the tube F, which is heated by conduction from the arms K, whereon subsidiary jets or frames L impinge. Additional heat is conducted to the burner tip or head J of the tube F, and the flame is protected by guards M. Modifications are described in which the channel B, the superheating- tube H, and the open space below the tube Fare dispensed with.
Patent GB-189729581-A (GB)
Title: Certain Improvements in Saddle Pins for Bicycles and other Velocipedes and Motor Carriages.
Inventor: LANCELOTT GEORGE ERNEST
Filed: 1897-12-14
Granted: 1898-12-10
Abstract: 29,581. Lancelott, G. E., and Thomas, A. C. Dec. 14. Motor road vehicles.- Relates to saddle and seat supports for velocipedes and motor carriages. Fig. 2 shows the application to a bicycle. The limb B, which takes into the frame member E, is provided with a lug b<1>, and the horizontal limb A, to which the saddle D is clipped, is formed so as to take upon each side of the lug b<1>. The limbs A and B are pivoted together by means of a pin C, so that the saddle may be turned back, as shown in Fig. 2, and access obtained to the tube E, which may be used to carry the pump or other article. The saddle may be located in this position by an ordinary padlock for security against theft. When the limb A is turned into the horizontal position, the part a of the forked end takes against the limb B and forms a stop. The top of the limb may be closed by a cap. The Provisional Specification describes a locking-device in combination with the saddle pin.
Patent GB-189809595-A (GB)
Title: Improvements in or relating to Cycles.
Inventor: BOULT ALFRED JULIUS
Filed: 1898-04-26
Granted: 1899-02-11
Abstract: 9595. Boult, A. J., [Wisniewski, V.]. April 26. Bicycles; unicycles; driving-mechanism; frames. -The invention is shown as applied to a bicycle, but it is stated to be applicable to tricycles, and by dispensing with the rear wheel the cycle becomes a unicycle. The pedals a are mounted on the lower ends of rods &c. A which work between guiderollers b and are connected above to crank-pins g<1> on spur or chain wheels G which actuate pinions &c. H on the main axle. The saddle E is mounted on springs D and carries handles as shown. A small rear wheel may be carried on the backbone B. The rods A may be made of flexible steel bands.
Patent GB-189811504-A (GB)
Title: Improvements in and connected with Musical Drums and the like.
Inventor: BAKER JAMES ALBERT
Filed: 1898-05-20
Granted: 1898-10-15
Abstract: 11,504. Baker, J. A. May 20. Drums.-The hoops 4, which stretch the parchment, are connected by spring clips 5, formed as shown or otherwise. In a modification, the clips are rigid and consist of wires hooked over the edges of the hoops, or passed through holes in them.
Patent GB-189816031-A (GB)
Title: Improvement in Devices for Fastening Curtains and the like to their Holders.
Inventor: GOLBY FREDERICK WILLIAM
Filed: 1898-07-22
Granted: 1898-09-10
Abstract: 16,031. Golby, F. W., [Alker, H.]. July 22. Curtains, suspending.-To a strip or fillet L is hinged at b<1> another fillet B in several parts hinged together at b. Pegs a or projections f on L enter holes or grooves f<1> in B. The curtain is placed between the two fillets, and each section of B is secured by turning down a cranked wire d over a spring c. The fillets are suspended by eyes e, e<1> from the ordinary pole. The pole A itself may replace the fillet L as in Fig. 10 ; in this case the fillet B is secured by levers k pivoted at n and acted on by springs h.
Patent GB-189822682-A (GB)
Title: Improvements in or connected with Handles of Bats, Hammers, Sticks, or Clubs for Cricket, Tennis, Hockey, Golf, and other Implements Used in Games or Manufactures.
Inventor: DARLING JAMES
Filed: 1898-10-28
Granted: 1899-09-30
Abstract: 22,682. Darling, J. Oct. 28. Handles of implements such as cricket bats and hammers are constructed with internal metal spring strips embedded in gutta - percha and the like. As applied to the handles of cricket bats, of which two sectional views at rightangles to each other are given, a strip of spring steel a is embedded in gutta-percha c<1>, c<2> and riveted or otherwise secured at one end to the upper portion of the handle, the lower end of the spring, which is divided at a<2>, being free, when the bat is struck, to move relatively to the handle.
Patent GB-189822986-A (GB)
Title: Improvements in Swimming Appliances.
Filed: 1898-11-01
Granted: 1899-09-09
Abstract: 22,986. Clark, A. M., [Devers, P. A.]. Nov. 1. Swimming appliances.-To increase the foot power, a bent plate 1, applied to the back of the heel and secured by a stirrup 2 and ankle strap 3, bears hinged wings 4, 5, which are connected at the bottom by a flexible web 10 with stiffening- ribs 7, 8, 9. Subsidiary webs 11 occupy the angles between the wings and the attachment plate.
Patent GB-189824564-A (GB)
Title: Improvements in or connected with the Mixing of Substances.
Inventor: WALL DAVID WILLIAM
Filed: 1898-11-21
Granted: 1899-10-07
Abstract: 24,564. Wall, D. W. Nov. 21. Mixing flour &c.-Relates to a method and apparatus for mixing flour and water or liquor to form dough and for mixing other substances. The flour is fed from a hopper d into a container a, through the perforated bottom of which it is swept by revolving brushes e. Water from the receptacle 0 is delivered by rose pipes n in a fine spray upon the descending cloud of flour, and converts it into dough, which accamulates in the rotating receptacle r.
Patent GB-189827521-A (GB)
Title: The Manufacture and Production of Certain Organic Sulphates and Substances Derived Therefrom.
Inventor: VERLEY ALBERT
Filed: 1898-12-30
Granted: 1900-03-30
Abstract: 27,521. Verley, A. Dec. 30. Chlorosulphonic acid is prepared by saturating sulphuric anhydride, either pure or mixed with common acid, with hydrogen chloride, and then distilling the mixture in a glass vessel. The pure acid boiling at 165‹ C. is thus obtained in one operation.
Patent GB-189905889-A (GB)
Title: Improvements in Apparatus suitable for Scoring in Games.
Filed: 1899-03-17
Granted: 1900-01-20
Abstract: 5889. Be la Rue & Co., T., and Charpiat, L. March 17. Scoring and marking.- Relates to the apparatus described in Specification No. 11,935, A.D. 1897, for scoring games, the object being to protrude two different lengths of each tongue c to score two numbers. Two pins a, b with push-buttons are provided, and the slot in the tongue has an enlargement c<1> for a large portion a<1> of the first pin a, and another enlargement c<2> for a large portion b<1> of the second pin b. When the pin a is depressed, the tongue is protruded by its spring d<1> until the rear end of the enlargement c<2> is against the part b<1>, and the tongue is then further protruded on pressing the button b. To permit the tongue to be pressed back again, the sides of the slot between the two enlargements are bevelled as shown in Fig. 11.
Patent GB-189906458-A (GB)
Title: Improvements in Umbrellas and Sunshades.
Inventor: FOLEY NELSON
Filed: 1899-03-25
Granted: 1900-04-25
Abstract: 6458. Foley, N. March 25. Telescopic umbrellas, parasols, and like sunshades; walking -sticks.-In umbrellas, sunshades, &c., the handle and point are made to telescope on and into the body of the stick. In Fig. 2, the handle b is shown telescoped over the ends of the ribs. A double spring catch f catches on the edge of the washer e when the handle is pulled out, and holds the handle firmly when the umbrella is used as a walking- stick. Fig. 5 shows the point k telescoped inside the tubular stick. The double spring catch l springs out and catches against the end of the tube, when the point k is drawn out. The stop o, which prevents the point from being drawn too far out, is attached to a washer m, which prevents rain from entering the umbrella.
Patent GB-189909517-A (GB)
Title: Improved Method for the Production of Figured Pile Fabrics.
Inventor: SCHWARTZ RUDOLF
Filed: 1899-05-05
Granted: 1900-03-03
Abstract: 9517. Schwartz, R. May 5. Pile fabrics.-In making double-figured pile fabrics with frieze or mirror effects, two pile warps are employed, one of which x is interwoven in both fabrics a, b so as to form the pile for both and the frieze and mirror effects y, z for one only, viz., b, while the other k is interwoven in the other fabric a so as to form the frieze and mirror affects only.
Patent GB-189911897-A (GB)
Title: New and Useful Distributor for Tooth-powder and the like.
Inventor: COHN JOSEPH
Filed: 1899-06-07
Granted: 1899-11-11
Abstract: 11,897. Cohn, J. June 7. Measured quantities, delivering.- Relates to a powder distributer. The tooth or like powder is placed in a closed hopper c, supported between standards b. At the bottom of the hopper is a grooved roller e which,when turned, delivers definite quantities of powder upon the brush x placed on the projection i.
Patent GB-189912469-A (GB)
Title: An Improved Cash-register and Check-till.
Inventor: KOENIG HUGO
Filed: 1899-06-15
Granted: 1899-10-14
Abstract: 12,469. Koenig, H., and Hartmann, S. June 15. Tills.-A handle g is turned at each transaction so as to rotate indicator discs h and display the amount through apertures in the front and back of the casing, and, by means of a pawl v and ratchet-wheel w, to drive feed-rolls c, d and deliver a proportionate length of a graduated strip b. The fractional divisions, Fig. 1, may be printed by a roller during issue ; the handle g and disc h may be replaced by index-fingers moving over dials. A partition in the drawer carries a spring slip pawl m, which allows the drawer to be pulled out at any time, but prevents its full return except when the notch n is in its line of travel, that is, when the disc h has been turned back to zero. A cam-slot in the side of the drawer actuates the lower of a pair of knives k, k', and cuts off the protruding strip. The graduation on the end of the strip at any time shows the total of all the transactions.
Patent GB-189913093-A (GB)
Title: Improvements in Body Belts, Abdominal Binders, Corsets and the like.
Inventor: TEUFEL WILHELM JULIUS
Filed: 1899-06-23
Granted: 1899-07-29
Abstract: 13,093. Teufel, W. J. June 23. Belts; corsets.-Relates to body belts, abdominal binders, corsets, and the like, and consists in providing them with a pad or cushion a along the lower front edge, and with an adjustable strap A by which the belt &c. is held up against the body. When it becomes necessary to enlarge the belt, it is also necessary that the back stiffeners D should not be moved so that they may continue to support the spine. To effect this the stiffeners D are rigidly connected together by bars or their equivalents d, and the laces E for the adjustment of the belt are attached as shown.
Patent GB-189916574-A (GB)
Title: The Manufacture or Production of Anthraquinone Dyestuffs.
Inventor: NEWTON HENRY EDWARD
Filed: 1899-08-15
Granted: 1900-06-16
Abstract: 16,574. Newton, H. E., [Farbenfabriken vorm. F. Bayer & Co.]. Aug. 15. Dyes, artificial.-Relates to the production of the disulphonic acids of diamidoanthrarufin and diamidochrysazin described in Specification No. 12,011, A.D. 1897, and consists in reducing the disulphonic acids of dinitroanthrarufin and dinitrochrysazin, by heating these bodies with sulphur sesquioxide at, for example, 50‹ to 80‹ C. When the dinitro compound has disappeared, the mixture is poured into ice water, the solution is filtered, and the diamido compound is precipitated by common salt.