Patent SG-11201808085W-A (SG)
Title: Protease-activated t cell bispecific molecules
Inventor: BRUENKER PETER
IPC: C07K16/46
Filed: 2017-03-20
Abstract: FcKnob) PG LALA Fc(Hole) P329G LALA = (54) Title: PROTEASE-ACTIVATED T CELL BISPECIFIC MOLECULES FIG. 1A Protease site with GS linker Anti CD3 scFv 4.15.64 anti-CD3 V CH1 Common Light Chain 7859 W O 20 17 / 16 25 87 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/162587 Al 28 September 2017 (28.09.2017) WIPO I PCT IIIII111111110111011111111111$111110 011IIIIII0111111111110111111111111111 (51) International Patent Classification: C07K 16/46 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01) C07K 16/32 (2006.01) C07K 16/28 (2006.01) (21) International Application Number: PCT/EP2017/056556 (22) International Filing Date: 20 March 2017 (20.03.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16161740.2 22 March 2016 (22.03.2016) EP 62/433,327 13 December 2016 (13.12.2016) US (71) Applicant (for all designated States except US): F. HOFF- MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, 4070 Basel (CH). (71) Applicant US only): HOFFMANN-LA ROCHE INC. [US/US]; Overlook at Great Notch, 150 Clove Road, 8th Floor, Suite 8 - Legal Department, Little Falls, New Jersey 07424 (US). (72) Inventors: BRUENKER, Peter; Burgwiesenstrasse 3c, 8335 Hittnau (CH). CROASDALE-WOOD, Rebecca; 39 college close, Longridge, Preston Lancashire PR3 3AX (GB). KLEIN, Christian; Chapfstrasse 26B, 8906 Bon- stetten (CH). SCHANZER, Juergen Michael; Metzstr. 26, 81667 Mlinchen (DE). STUBENRAUCH, Kay-Gun- nar; Parkstrasse la, 82377 Penzberg (DE). UMANA, Pablo; Felsenrainstrasse 28, 8832 Wollerau (CH). GEI- GER, Martina; Muehlestrasse 4a, 8912 Obfelden (CH). SULLIVAN, Eric; c/o Roche Sequencing Solutions, Inc., 4300 Hacienda Drive, Pleasanton, California 94588 (US). PATEL, Jigar; c/o Roche Sequencing Solutions, Inc., 4300 Hacienda Drive, Pleasanton, California 94588 (US). (74) Agent: BRODBECK, Michel; Grenzacherstrasse 124, 4070 Basel (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, [Continued on next page] (57) : The present invention generally relates to novel protease-activatable T cell activating bispecific molecules and idiotype-specific poly- peptides acting as masking moieties. The present in- vention also relates to polynucleotides encoding such protease-activatable T cell activating bispecific mo- lecules and idiotype-specific polypeptides, and vec- tors and host cells comprising such polynucleotides. The invention further relates to methods for produ- cing the protease-activatable T cell activating bispe- cific molecules and idiotype-specific polypeptides of the invention, and to methods of using these pro- tease-activatable T cell activating bispecific mo- lecules and idiotype-specific polypeptides in the treatment of disease. WO 2017/162587 Al MIDEDIMOMOIDEIRMEMOMOHEIHIONDERVOIMIE DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))