Patent SG-11201806982P-A (SG)
Title: Cinnolin-4-amine compounds and their use in treating cancer
Inventor: PIKE KURT
IPC: C07D405/14
Filed: 2017-03-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/162605 Al 28 September 2017 (28.09.2017) WIPO I PCT 111111111111110111011111111111010111110111011111111011111111111111111111111111110111111 (51) International Patent Classification: CO7D 405/14 (2006.01) A61P 35/00 (2006.01) A61K 31/502 (2006.01) (21) International Application Number: PCT/EP2017/056592 (22) International Filing Date: 20 March 2017 (20.03.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/310,883 21 March 2016 (21.03.2016) US (71) Applicant: ASTRAZENECA AB [SE/SE]; S-151 85 Sodertalje (SE). (72) Inventors: PIKE, Kurt, Gordon; AstraZeneca, Hodgkin Building, Chesterford Research Park, Little Chesterford Essex CB10 1XL (GB). BARLAAM, Bernard, Chris- tophe; AstraZeneca Darwin Building, Cambridge Science Park, Milton Road, Cambridge Cambridgeshire CB4 OWG (GB). (74) Agent: JONES, Teyrnon; ASTRAZENECA INTELLEC- TUAL PROPERTY, Mereside, Alderley Park, Maccles- field Cheshire SK10 4TG (GB). = (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) Published: — with international search report (Art. 21(3)) W O 20 17 / 16 2605 Al (54) Title: CINNOLIN-4-AMINE COMPOUNDS AND THEIR USE IN TREATING CANCER 0 R 2 R 3 (I) (57) : This specification generally relates to compounds of Formula (I). And pharmaceutically acceptable salts thereof, where R I , R 2 and R 3 have any of the meanings defined herein. The specification also relates to the use of such compounds and salts thereof to treat or prevent ATM kinase mediated disease, including cancer. The specification further relates to crystalline forms of compounds of Formula (I) and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds and salts thereof; kits comprising such compounds and salts thereof; methods of manufacture of such compounds and salts thereof; intermediates useful in the manufacture of such compounds and salts thereof; and to methods of treating ATM kinase mediated dis - ease, including cancer, using compounds of Formula (I) and salts thereof alone or in combination with other therapies.