Patent SG-11201804489V-A (SG)
Title: Antibiotic fiirv 104/18 complex and the isolated individual factors thereof
Inventor: CARRANO LUCIA
IPC: C12N1/20
Filed: 2016-11-24
Abstract: Title: ANTIBIOTIC FIIRV 104/18 COMPLEX AND THE ISOLATED INDIVIDUAL FACTORS THEREOF yH 3 H 3 ( I ) (57) : An antibiotic FIIRV 104/18 complex comprising factors F793, F795, F797, F813 and F683, of formula (I), wherein R represents a glycosidic radical as defined in the specification, the isolated individual factors, a method for their production by cul - tivation of Dactylosporangium FIIRV sp. 104/18 DSM 32068 under aerobic conditions, and pharmaceutical foiinulations containinig them as active ingredient and their use in the treatment of bacterial infections, caused by bacteria of at least one of the genera Entero - cocci, Streptococci, Staphylococci and Moraxella, including bacteria of multi resistant strains, in particular Staphylococcus spp., Streptococcus spp, and Enterococcus spp. resistant to methicillin and/or vancomycin. (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau 111111111M 1111111111111111111111111111111111111111111111111111111R111111111111111 (10) International Publication Number WO 2017/093114 Al WIPO I PCT (43) International Publication Date 8 June 2017 (08.06.2017) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art 21(3)) with (an) indication(s) in relation to deposited biological material furnished under Rule 13bis separately from the description (Rules 13bis.4(d)(i) and 48.2(a)(viii)) with sequence listing part of description (Rule 5.2(a)) (51) International Patent Classification: A61K 31/704 (2006.01) A61P 31/04 (2006.01) C12N 1/20 (2006.01) (21) International Application Number: PCT/EP2016/078678 (22) International Filing Date: 24 November 2016 (24.11.2016) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 15197443.3 2 December 2015 (02.12.2015) EP (71) Applicant: FONDAZIONE ISTITUTO INSUBRICO DI RICERCA PER LA VITA [IT/IT]; Via Lepetit, 34, 21040 Gerenzano (VA) (IT). (72) Inventors: CARRANO, Lucia; Via Mentana, 1, 20025 Legnano (MI) (IT). ABBONDI, Monica; Viale Brianza, 64, 22060 Cabiate (CO) (IT). CARENZI, Giacomo; Via Orazio, 8, 21052 Busto Arsizio (VA) (IT). BRUNATI, Mara; Via Quinto Alpini, 2, 22077 Olgiate Comasco (CO) (IT). SIGURTA', Alessandro; Via Don Luigi Monza, 7, 21047 Saronno (VA) (IT). TARAVELLA, Anna; Via Carlo Marx, 22, 21047 Saronno (VA) (IT). TURCONI, Paola; Via Benedetto Croce, 60, 21053 Castellanza (VA) (IT). CANDIANI, Gianpaolo; Via Vincenzo Bellini, 2C, 20064 Gorgonzola (MI) (IT). (74) Agents: RIPAMONTI, Enrico et al.; c/o Giambrocono & C. S.p.A., Via Rosolino Pilo 19/B, 20129 Milano (MI) (M. W O 20 17 /093 114 Al