Patent SG-11201901077R-A (SG)
Title: Anti-tigit antibodies, anti-pvrig antibodies and combinations thereof
Inventor: WHITE MARK
IPC: C07K16/28
Filed: 2017-08-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1#111011110111010101111101 110 1 001111110110011111H11011111011 ill Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/033798 Al 22 February 2018 (22.02.2018) WIP0 I PCT (51) (21) (22) (25) Filing Language: (26) (30) (71) (72) International Patent Classification: C07K 16/28 (2006.01) A61K 39/00 (2006.01) International Application Number: PCT/IB2017/001256 International Filing Date: 17 August 2017 (17.08.2017) Publication Language: Priority Data: 62/376,334 17 August 2016 (17.08.2016) 62/376,335 17 August 2016 (17.08.2016) 62/417,217 03 November 2016 (03.11.2016) 62/477,974 28 March 2017 (28.03.2017) 62/513,771 01 June 2017 (01.06.2017) 62/513,916 01 June 2017 (01.06.2017) 62/513,775 01 June 2017 (01.06.2017) 62/538,561 28 July 2017 (28.07.2017) Applicant: COMPUGEN LTD. [IL/IL]; 26 Harokmim Street, 5885849 Holon (IL). Harokmim c/o Compugen Ltd., 26 Harokmim Street, 5885849 Holon (IL). STAPLETON, Lance; c/o Compugen, Ltd., 26 St., 5885849 Holon (IL). DRAKE, Andrew, W.; c/o Holon Harokmim Compugen, Ltd., 26 Harokmim St., 5885849 (IL). GOZLAN, Yosi; c/o Compugen, Ltd., 26 St 5885849 Holon (IL). VAKNIN, Ilan; c/o , Compugen, English 26 Harokmim English o Compugen, Ltd., 26 Harokmim St 5885849 Holon (IL). TIRAN, 5885849 US gen, Ltd., 26 Harokmim St US TURI, US 5885849 US Ltd., 26 US Kyle; US Holon US 26 Harokmim US c/o Compugen, OPHIR, Eran; c/o Compugen, Ltd., 26 Harokmim St., Ltd., 26 Harokmim St 5885849 Holon (IL). , SAMEAH-GREENWALD, Shirley; c/o Compugen, Ltd., St 5885849 Holon (IL). DASSA, Liat; c/ , , Zohar; c/o Compugen, Ltd., 26 Harokmim St , Holon (IL). COJOCARU, Gad., S.; c/o Compu- 5885849 Holon (IL). KOT- , Maya; c/o Compugen, Ltd., 26 Harokmim St., Holon (IL). CHENG, Hsin-Yuan; c/o Compugen, Harokmim St 5885849 Holon (IL). HANSEN, , c/o Compugen, Ltd., 26 Harokmim St., 5885849 (IL). GILADI, David, Nisim; c/o Compugen, Ltd., St, 5885849 Holon (IL). SAFYON, Einav; Ltd., 26 Harokmim St, 5885849 Holon (IL). 5885849 Ltd., 26 Ltd., 26 Richard; San- Holon 5885849 Harokmim Holon (IL). PRESTA, Leonard; c/o Compugen, Harokmim St , 5885849 Holon (IL). THEOLIS, — = Inventors: WHITE, Mark; c/o Compugen Harokmim St., 5885849 Holon (IL). KUMAR, c/o Compugen, Ltd., 26 Harokmim St 5885849 , = (IL). DESAI, Radhika; c/o Compugen, Ltd., 26 St 5885849 Holon (IL). WALL, Patrick; c/o , _ deep; c/o Compugen Ltd., 26 Harokmim Street, = Holon (IL). CHAN, Christopher; c/o Compugen Harokmim Street, 5885849 Holon (IL). LIANG, Spencer; Ltd., 26 Compugen, Ltd., 26 Harokmim St , 5885849 Holon (IL). = (54) Title: ANTI-TIGIT ANTIBODIES, ANTI-PVRIG Human PVRIG WT Full length Human PVRIG sequence.starting from position MGHRTLVLPWVIITLCVTAGTPEVVVVIVRMEATELSSETIRCGFLGSGS ANTIBODIES AND COMBINATIONS THEREOF SLVIVSLVGGPNGAGGTTLAVLHPERGIR = - FIG. 1 = = 21- alternative methionine = = = = = OWAPAROARWETOSSISLILEGSGASSPCANTITCCKFASEPEGSWEACGSLPPSSDPGLSAPPTPAPILRADLAGILGV SGVLLFGONLLHIIRRHKHRPAPRLCIPSRTSPQAPRARAWAPSQA (SEQ ID NO: 1) Human . PVRIG sequence starting from position 1 methionine MRTEAQVPALCIPPEPGLEGAMGHRTLVLPWVIITLCVTAGTPEVWVQVRMEATELSSFTIRCGFLGSGSISISTI/SM GPNLJAGG i I LAVLHPERGIRCIWAPARCIARWEIGSSISLILEGSGASSPCANTTFCCKFASEPEGSWEACGSLPPSSDPG = 11 .4 GO CT IN M M 0 --.... 00 1-1 C:::: ) (57) : Anti-PVRIG and anti-TIGIT antibodies ei LSAP PTPAPILRADLAG I LGVSGVLLFGCVYLLH LLRR H ICH RPAPRLOPS RTSPQAPRARAWAPSQA are provided. (SEQ ID NO:2) C [Continued on next page] WO 2018/033798 Al MIDEDIMOMOIDEIREIHRIIMMEIHMODEVOIMIE (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(i)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a))