baber/WOPTO huggingface dataset:
Patent PT-2292229-E (PT)
Title: Tamper resistant oral pharmaceutical dosage forms comprising an opioid analgesic
Inventor: MANNION RICHARD OWEN
IPC: A61K9/22
Filed: 2007-08-24
Abstract: The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.
Patent PT-656786-E (PT)
Inventor: KELLY GRAHAM EDMUND
IPC: A23L1/30
Filed: 1993-05-19
Abstract: Compositions enriched with natural phyto-oestrogens or analogues thereof selected from Genistein, Daidzein, Formononetin and Biochanin A. These may be used as food additives, tablets or capsules for promoting health in cases of cancer, pre-menstrual syndrome, menopause or hypercholesterolaemia.
Patent PT-639224-E (PT)
Inventor: ERBE DAVID V
IPC: A61K38/00
Filed: 1993-04-28
Abstract: This invention concerns selectin variants having an amino acid alteration at a site or sites of a selectin lectin domain amino acid sequence within a region defined by binding sites recognized by blocking monoclonal antibodies to the corresponding selectin unaltered in the lectin domain. Nucleotide sequences encoding such variants, expression vectors containing such nucleotide sequences, end host cells transformed with such expression vectors are also within the scope of the invention.
Patent PT-686037-E (PT)
Inventor: HODGEN GARY D
IPC: A61P19/08
Filed: 1994-02-18
Abstract: A method of hormone replacement therapy involves the administration of estrogen together with an amount of antiprogestin which inhibits estrogen-induced endometrial proliferation in a woman.
Patent PT-705514-E (PT)
Inventor: DUNN TAVE P
IPC: H04M11/06
Filed: 1994-06-07
Abstract: A method and apparatus for connecting a programmable computing device to a digital telephone via an adapter. The digital telephone includes an option bay connection, having a hierarchical control protocol. The option bay connection makes available several types of information including local analog audio, and analog voice, digital voice, digital data and telephone control streams. The adapter passes the telephony control data to and from a programmable computing device such as a personal computer, enabling an application operating on the computing device to control or monitor the operation of the telephone. The adapter includes a microcontroller and an interface for a serial port and can thus be connected to the serial port of the programmable computing device.
Patent PT-707121-E (PT)
Inventor: PARENTI GIUSEPPE
IPC: E04H7/20
Filed: 1995-10-10
Abstract: Reinforced concrete panel for the manufacture of aboveground circular tanks, of the type comprising a wall (1) fitted with a number of horizontal stiffening ribs (3) which contain holes for the passage of pre-stressing cables, wherein the said wall is flat and the said holes are arc-shaped, and a method of manufacture of said panels comprising the following stages:   insertion of a flexible tubular element (11), of the same length as an arc which presents a radius equal to the radius of the tank and a chord equal to the width of the panel, into a mould with mobile sides (8,9), on a pair of pegs (10) fitted to the sides at the horizontal ribs (3) of the panel; approach of the mobile sides (8,9) until the mould closes, so that the said flexible tubular element (11) takes on the arc shape required; installation of reinforcement and laying of concrete; concrete shaving; curing and removal of finished product.   <IMAGE>
Patent PT-728200-E (PT)
Title: Haemophilus transferrin receptor genes
Inventor: LOOSMORE SHEENA
IPC: A61K9/48
Filed: 1994-11-07
Abstract: Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminants derived from bacteria normally containing the Tbp1 or Tbp2 proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection. Also provided are recombinant Tbp1 or Tbp2 and methods for purification of the same. Live vectors expressing epitopes of transferrin receptor protein for vaccination are provided.
Patent PT-774213-E (PT)
Inventor: WEISS ARNO
IPC: A24B7/00
Filed: 1996-11-15
Abstract: The method involves veins and leaf material being separated for conditioning, cutting and drying. The veins and the leaf material are then mixed for conditioning and drying together. The tobacco veins before or after the cutting and-or the leaf material, after conditioning are provided with a casing. The veins before cutting are conditioned at a humidity of approximately 24%. The conditioned veins before cutting are stored for at least 1.5 hours, approximately 2 hours, in a closed casing. The veins are cut with a cut width of approximately 0.2 mm. The cut veins are expanded.
Patent PT-862485-E (PT)
Inventor: NAGYPAL TIBOR
IPC: A61N5/067
Filed: 1996-04-18
Abstract: PCT No. PCT/AT96/00075 Sec. 371 Date Dec. 17, 1998 Sec. 102(e) Date Dec. 17, 1998 PCT Filed Apr. 18, 1996 PCT Pub. No. WO97/19725 PCT Pub. Date Jun. 5, 1997An apparatus for the photodynamic treatment of living beings or organs thereof which includes a light source, a switching device, a current source, and a computer. The light source is controllable with respect to intensity, time, wavelength, and/or spectral bands by the computer in order to obtain a predetermined spectral pattern (photon energy pattern), which is preferably a pattern sequence.
Patent PT-851857-E (PT)
Inventor: MULLER GEORGE W
IPC: A61P35/02
Filed: 1996-08-29
Abstract: Novel nitriles are inhibitors of tumor necrosis factor  alpha  and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A typical embodiment is 3-Phthalimido-3-(3,4-dimcthoxyphenyl)propionitrile.
Patent PT-911328-E (PT)
Inventor: MAKOTO TAKEMURA
IPC: A23K20/195
Filed: 1996-11-22
Abstract: An antibacterial drugs having excellent antibacterial activities and high safety is disclosed, which comprises as an aqctive ingredient, quinolone derivatives which have a substituted aminocycloalkylpyrrolidine as a substituent and are further substituted with various substituents, represented by formula (I), and its salts and hydrates thereof: <CHEM>  wherein Q is represented by formula (II) or (IV). <CHEM>
Patent PT-896577-E (PT)
Inventor: KLAR ULRICH
IPC: A61K31/44
Filed: 1997-01-31
Abstract: PCT No. PCT/EP97/00440 Sec. 371 Date Jul. 30, 1998 Sec. 102(e) Date Jul. 30, 1998 PCT Filed Jan. 31, 1997 PCT Pub. No. WO97/28156 PCT Pub. Date Aug. 7, 1997The invention relates to pharmacologically active compounds that have the ability to influence the polymerisation and depolymerisation of tubulin. A range of natural mitosis toxins are used as anti-tumor agents or are in the process of being clinically tested. There are various classes of such mitosis toxins that either demonstrate their cytotoxic action by inhibiting the polymerisation of microtubules in the spindle system (for example, Vinca alkaloids, colchicine) or achieve their cytotoxic action by a GTP-independent increase in the polymerisation of the tubulin and by preventing the depolymerisation of microtubules (for example, taxol, taxoters). Owing to their physico-chemical properties, hitherto not understood, and as a result of the characteristics of neoplastic cells, mitosis toxins have a certain selectivity for tumor cells, but there still remains a not inconsiderable cytotoxicity towards non-transformed cells. The search for more selective compounds that are easier to manufacture and-like the taxane class of substances-are able to inhibit the depolymerisation of microtubules, had, surprisingly, led to the discovery of borneol esters, as described in P 4416374.6 and 19513040.5. Structural modifications in that class of compounds have revealed a considerable potential for optimisation in respect of the action on microtubules. Outstanding results have been obtained, inter alia, by formal esterification of those broneols with an acid of the Sk-H type. By synthesising the taxol derivatives described herein, in which the isoserine chain of the taxol has been replaced by Sk, the intention was to study whether it is also possible in that class of substances to achieve an improved stabilisation of microtubules, compared with taxol.
Patent PT-913151-E (PT)
Inventor: KAWAMOTO ISAO
IPC: A61P31/00
Filed: 1997-05-08
Abstract: 1-Methylcarbapenem derivatives having the following formula: <CHEM>  (wherein, R<1> represents a group of the following formula: <CHEM> R<2> represents a hydrogen atom or an alkyl group and R<3> represents a hydrogen atom or an alkyl group), or pharmacologically acceptable salts or esters thereof are useful as the active ingredient in a composition for an anti-helicobacter pylori (a treatment or prevention of infectious diseases caused by helicobacter pylori, particularly treatment).
Patent PT-907439-E (PT)
Inventor: SPIQUEL JACQUES
IPC: B22D11/055
Filed: 1997-03-27
Abstract: PCT No. PCT/FR97/00547 Sec. 371 Date Jan. 22, 1999 Sec. 102(e) Date Jan. 22, 1999 PCT Filed Mar. 27, 1997 PCT Pub. No. WO97/37793 PCT Pub. Date Oct. 16, 1997The mold comprises a tubular metal component (4), made of copper or a copper alloy, cooled by water circulation against its external wall and intended to ensure that the cast metal undergoes peripheral solidification on contact with its internal wall, and an uncooled feed head (9) made of a thermally insulating refractory, intended to contain cast metal in the liquid state and sitting on top of the cooled metal component (4) and defining with it a continuous sizing passage for the cast metal. A horizontal metal annulus (16) cooled by internal circulation is added between the feed head (9) and the tubular component (4) and aligned with the internal wall of the latter.
Patent PT-975602-E (PT)
Inventor: GLUCHOWSKI CHARLES
IPC: A61P9/12
Filed: 1998-04-10
Abstract: This invention is directed to novel imidazole and imidazoline derivatives which are selective agonists for cloned human alpha2 adrenergic receptors. This invention is also related to the use of these compounds for the treatment of any disease where modulation of the alpha2 receptors may be useful. The invention further provides for a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.
Patent PT-1007523-E (PT)
Inventor: MIKKELSEN IVAN
IPC: C07D405/12
Filed: 1998-07-20
Abstract: The present invention relates to indole and 2,3-dihydroindole derivatives having formula (I)  or any of its any of its enantiometers or any mixture thereof, or an acid addition salt thereof, wherein A, R1, R2, R3, W, X, Y and Z are as described in the description. The compounds are potent serotonin reuptake inhibitors and have 5-HT1A receptor antagonistic activity.
Patent PT-1015698-E (PT)
Inventor: HODGSON WILLIAM
IPC: E01B19/00
Filed: 1998-09-18
Abstract: A damper for reducing the track nose emitted by a rail system comprises a deformable material attachable to a surface of the rail, incorporating a plurality of elongate discontinuous resonant members of a stiff material as compared to the deformable material, sized to contain at least two resonant frequencies in the range of interest. The resonant members are suitably of steel or other metallic material. They can be of different profile, to form a resonant system with at least two resonant frequencies in the relevant frequency range. They are suitably embedded in the deformable material, to ensure adequate vibrational transfer from the rail to the resonant members and also provide environmental protection. The deformable member is visco-elastic, for example rubber or rubber-like material. This may be preformed and glued to the rail, or it can be cured in place on the rail. The damper is positioned on the rail at the junction between the web and the foot of the rail. One resonant member can be an elongate angled section, the angle preferably matching the angle between external surfaces of the head and foot. Another resonant member can be a solid elongate block, the external faces adjacent the web and foot being angled to match.
Patent PT-972103-E (PT)
Inventor: CUZEL ALAIN
IPC: D06F75/14
Filed: 1998-12-24
Abstract: PCT No. PCT/FR98/02870 Sec. 371 Date Sep. 22, 1999 Sec. 102(e) Date Sep. 22, 1999 PCT Filed Dec. 24, 1998 PCT Pub. No. WO99/37850 PCT Pub. Date Jul. 29, 1999A pressing iron reservoir composed of a lower half-shell having at least one annular conformation and an upper half-shell having at least one annular conformation provided to interengage in and/or above the corresponding annular conformation of the lower half-shell. At least one of the conformations is formed with a covering attached in an irreversible manner and serving as a seal.
Patent PT-1026635-E (PT)
Inventor: MOON JOO HEE
IPC: H04N19/87
Filed: 1999-09-24
Abstract: In order to describe motion information about the video content more effectively, a motion descriptor generating apparatus by using accumulated motion histogram and a method therefor are provided, in which accumulated motion histograms are generated and motion descriptors are generated by using the accumulated motion histograms, wherein the motion descriptor generating apparatus by using accumulated motion histogram, includes a motion histogram generating unit for respectively generating motion histogram with relation to intensity data and direction data of an input motion, an accumulated motion histogram generating unit for generating two-dimensional accumulated motion histogram in a predetermined sequence by using the motion histogram which is generated in said motion histogram generating unit, and a motion descriptor generating unit for structuring (hierarchy structure) video into certain units according to a change amount of the accumulated motion histogram with the lapse of time, which is generated in said accumulated motion intensity histogram generating unit, and generating a motion descriptor which describes motion characteristics with relation to the respective structured units. <IMAGE>
Patent PT-1053193-E (PT)
Inventor: EXNER HUBERTUS
IPC: B65G47/72
Filed: 1999-01-28
Abstract: A method for distributing a flow of bulk material amongst several sub-flows. The method is characterized in that the flow of bulk material accumulates in an essentially vertically oriented pipe. The sub-flows branch off from the accumulated flow of bulk material are led over a horizontal or slightly inclined section so that a bank forms inside and blocks the sub-flow. The bulk material is then removed from the sub-flow by vibration, the bank block being constantly replaced by the particles which slide down correspondingly. A device for distributing a flow of bulk material amongst several sub-flows utilizes a supply container located upstream connected to at least one substantially vertical distribution pipe connected downstream. The distribution pipe has at least one part that branches off with a branch pipe connected thereto and with the branch pipe having a section which is positioned at a slightly smaller downstream angle than the bank of bulk material.
Patent PT-1121104-E (PT)
Inventor: KHANNA SATISH CHANDRA
IPC: A61K9/22
Filed: 1999-10-01
Abstract: Pharmaceutical composition capable of releasing a therapeutically effective dose of active agent, e.g., rivastigamine, in a time-controlled manner.
Patent IE-32272-L (IE)
Title: Container
IPC: B65D88/12
Filed: 1968-01-18
Abstract: 1,174,541. Containers. NIEDERSACHSISCHE WAGGONFABRIK JOSEPH GRAAFF G.m.b.H. 15 Jan., 1968 [20 Jan., 1967], No. 2105/68. Heading B8P. [Also in Division E2] A container comprises a pair of opposed side walls, a roof including a first part 7 movable transversely with respect to one of the side walls and carried by a first arm pivotally mounted on said container and a second part 6 movable transversely with respect to the other side wall and carried by a second arm pivotally mounted on said container, and means for resiliently biasing each said arm against movement of the respective roof part transversely with respect to the respective side wall, each of said roof parts including a first and second portion 7a, 7b pivotally interconnected transversely to the direction of movement of the said roof parts, and each of said roof parts including means movable in a guide which is transverse to said side walls. As illustrated the second or outer portion 7b is rigidly connected to support arms 11-13 pivoted at 14-16 on the side wall 1 of the container. The first or inner portion 7a of each part includes at each end a roller 20 which is movable in a guide (19), (Fig. 6, not shown), and which constitutes said movable means. The biasing means comprises torsion bars 17, 18 which are each clamped at one end to the side wall and attached at the other end to the arms 11, 13 respectively. Twisting of the bars during opening of each roof part opposes the weight of that part. Cover plates 10, (21), (Fig. 6, not shown), are provided for protecting the hinges 9 and guides.
[GB1174541A]
Patent IE-840182-L (IE)
Title: Des-proline vasopressin antagonists
IPC: A01N57/12
Filed: 1984-01-27
Abstract: Compounds of the formula: <IMAGE> wherein: R1=H, OH, alkyl (C1-C4) optionally substituted by halogen, OH or NHOH; optionally substituted phenyl; or alkoxy (C1-C4); R2 and R3=alkyl (C1-C5) or optionally substituted phenyl or together=-(CH2)m-, m=4 or 5; R4=alkyl (C1-C18), alkenyl (C2-C18) or optionally substituted benzyl or phenyl; and n=0 or 1. are agriculturally useful as fungicides or bactericides for protecting plants.
[US4542023A]
Patent IE-810201-L (IE)
Title: Pouch packaging machine
IPC: A23L27/30
Filed: 1981-02-03
Abstract: Associated with a horizontal pouch making machine for packaging a free flowing granular product between webs of flexible packaging material is a product lay down mechanism operable for receiving measured amounts of the product and depositing it in precisely defined areas of one of the webs being processed and in a flattened configuration such as to minimize the amount of packaging material required to contain said product. A product shaping member contacting the web surface during a dwell in the web feed cycle is formed with apertures which in combination with the web define cavities or molds which shape each deposit of product delivered thereto into the desired configuration having uniform height over substantially the entire surface area of the web portion upon which it is laid.
[US4359072A]
Patent IE-900250-L (IE)
Title: Immunogenic compositions against gastrin peptides
IPC: C07K16/00
Filed: 1990-01-23
Abstract: Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
Patent IE-35037-L (IE)
Title: Anhydrous magnesium chloride
IPC: C01F5/34
Filed: 1971-03-29
Abstract: 1353353 Anhydrous magnesium chloride SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ NV 19 April 1971 [31 March 1970] 25517/71 Heading C1A Anhydrous magnesium chloride is prepared by evaporating water at 200-300 C. and at under 2-5 atmospheres absolute from an aqueous solution containing exclusively or substantially magnesium chloride as dissolved salt to obtain a slurry in which the molar ratio between water and magnesium chloride is between 2 : 1 and 4À2 : 1 and in a second step evaporating water from this slurry in a fluidized bed the fluidizing gas being a drying gas and the temperature of the fluidized bed being below the melting point of magnesium chloride. The drying gas (e.g. hydrogen chloride) is defined as a gas capable of removing water from MgCl 2 .H 2 O without causing substantial hydrolysis to Mg(OH)Cl. The gas may be recycled to the fluidized bed after partial or total removal of water.
[GB1353353A]
Patent IE-40886-L (IE)
Title: Quinoxalinedioxide derivatives
IPC: A23K20/195
Filed: 1975-03-20
Abstract: 1450518 3-Substituted quinoxaline-2-carboxamide-1,4-dioxides PFIZER Ine 6 May 1975 [7 May 1974] 19058/75 Heading C2C Novel 3-substituted quinoxaline-2-carboxamide-1,4-dioxides having the general formula wherein X is a hydrogen atom or a substituent in the 6- or 7-position which is a halogen atom or a lower alkoxy, trifluoromethyl, methyl, lower alkyl sulphide, lower alkyl sulphoxide or lower alkyl sulphone group; Y is S, SO or SO 2 ; R 1 is a lower alkyl group substituted with a halogen atom or a hydroxy, lower alkoxy, amino, mono (lower alkyl) amino, di-(lower alkyl(amino, lower alkoxycarbonyl, carbamyl, mono- (lower alkyl)carbamyl, di-(lower alkyl)carbamyl, mercapto, sulpho, lower alkyl sulphide, lower alkyl sulphoxide, lower alkyl sulphone, acetoxy, pyrrolidino, piperidino, morpholino, thiomorpholino, piperazino, N-(lower alkyl) piperazino, N-hydroxy-(lower alkyl)piperazino, N-(lower alkanoyl) piperazino or N-carbo (lower alkoxy) piperazino group; R 2 is a hydrogen atom or a lower alkyl group; R 3 is a hydrogen atom or a phenyl, lower alkyl or substituted lower alkyl group wherein the substituent is ammo, mono-(lower alkyl)amino, di-(lower alkyl)amino, pyrrolidino, piperidino, morpholino, N-(lower alkyl)piperazino, N- hydroxy (lower alkyl)piperazino, N-(lower alkanoyl)piperazino, N-carbo (lower alkoxy)piperazino, pyrrolo, piperazino, imidazolidino, hydroxy, lower alkoxy, thio-(lower alkyl), carboxy, carbo (lower alkoxy), carbamyl, mono- (lower alkyl)carbamyl, di-(lower alkyl)carbamyl, lower alkanoyloxy or lower alkanoylamino, or R 2 and R 3 , when taken together with the nitrogen atom to which they are attached, form a pyrrolo, pyrrolidino, piperidino, morpholino, thiomorpholino, piperazino, N-(lower alkyl) piperazino, N - hydroxy(lower alkyl piperazino, N-(lower alkanoyl)piperazino or N-carbo-(lower alkoxy)piperazino group, and the pharmaceutically-acceptable acid addition salts of those compounds wherein at least one of R 1 and R 3 is a substituted lower alkyl group wherein the substituent is a basic group. The novel compounds may be used as antibacterial agents for the control of various pathogenic microorganisms and as animal growth promotants.
[GB1450518A]
Patent IE-33462-L (IE)
Title: Benzodioxole compounds
IPC: C07D317/72
Filed: 1969-06-18
Abstract: 1,269,774. Anti-inflammatory &c. compositions. LEO A.B. 16 June, 1969 [25 June, 1968], No. 30327/68. Heading A5B. [Also in Division C2] Pharmaceutical compositions, which may be administered orally, parenterally or by pellet implantation contain as active ingredients novel benzodioxole derivatives of the formula wherein R<SP>1</SP> is NH 2 , alkylamino, dialkylamino, morpholino, piperidino, pyrrolidino or dialkylaminoalkylamino, or OR<SP>9</SP> wherein R<SP>9</SP> is H, C 1-4 alkyl or a pharmaceutically acceptable inorganic or organic cation, R<SP>2</SP> and R<SP>3</SP> are the same or different and each is H or C 1-4 alkyl, R<SP>4</SP>, R<SP>5</SP> and R<SP>6</SP> are the same or different and each one is H, F, Cl, CF 3 , NO 2 or OH, C 1-4 alkyl, or C 1-4 alkoxy, R<SP>7</SP> is H or C 1-4 alkyl, R<SP>8</SP> is alkyl, alkenyl or cycloalkyl containing up to eight carbon atoms, optionally substituted with Cl, OH or C 1-4 alkoxy or an aryl group optionally substituted with not more than three equal or different substituents selected from Cl, F, CF 3 , NO 2 , OH, C 1-4 alkyl and C 1-4 alkoxy or R<SP>8</SP> forms together with R<SP>7</SP> and the carbon atom to which they are attached a cycloaliphatic ring containing up to seven carbon atoms, and pharmaceutically acceptable carriers. The above compositions, which may also contain other active ingredients such as analgesics, tranquillizers, steroids or hormones, have anti-inflammatory and/or analgesic and/or anti-pyretic activity.
[GB1269774A]