baber/WOPTO huggingface dataset:
Patent CA-2417011-A1 (CA)
Inventor: SCHAUWECKER FLORIAN
IPC: C12N15/66
Filed: 2001-04-25
Abstract: The invention relates to a method for producing novel modular enzyme systems by genetic engineering, which is characterized by a cyclic in vitro gene synthesis and which allows a specific recombination of the individual, gene-encoded modular components to novel enzyme systems. Examples of such modular enzyme systems are the non-ribosomal peptide synthetases (NRPS) or polyketide synthases (PKS) of type 1, that is the amino acid sequence of such an enzyme is characterized by being composed of a repetitive sequence of identical sequence sections or sequence sections that are very similar to one another.  Every single repetitive sequence is referred to as a module and every module allows the enzymatic incorporation of a specific substrate into the substance synthesized by the enzyme. The products synthesized by the NRPS and PKS  enzymes are often highly valuable as pharmaceuticals, such as the penicillins, vancomycins or erythromycins. The inventive method allows for an effective production of novel genes for modular enzymes, and the gene expression of said novel genes allows for the production of novel substances.
Patent CA-2417195-A1 (CA)
Inventor: KALLICK DEBORAH A
IPC: A61P19/00
Filed: 2001-07-25
Abstract: The invention provides human G-protein coupled receptors (GCREC) and polynucleotides which identify and encode GCREC. The invention also provides  expression vectors, host cells, antibodies, agonist, and antagonist. The invention also provides mehtods for diagnosing, treating, or preventing disorders associated with aberrant expression of GCREC.
Patent CA-2417914-A1 (CA)
Title: Cyclic oxyguanidine protease inhibitors
Inventor: WANG AIHUA
IPC: A61P7/02
Filed: 2001-08-02
Abstract: Cyclic oxyguanidine compounds, including compounds of Formulae (I and II), wherein R1, R3-R6, R21-R26, L, Y, Z, and A are set forth in the specificatio n, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin are described, Also described are methods for preparing the compounds of Formulae (I and II). Th e novel compounds of the present invention are potent inhibitors of proteases,  especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin, or are  intermediates useful for forming compounds having antithrombotic activity. T he invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thombus formation, and inhibiting embolus formation in a mammal, comprising a compound of the invention in a pharmaceutically acceptable carrier. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents.
Patent CA-2418986-A1 (CA)
Title: 5 litre keg cooler
Inventor: STANLEY DAVID
IPC: F25D31/00
Filed: 2003-02-07
Abstract: The present invention is an innovation of a container which will be used as a reusable cooler for a standardized 5 litre or smaller portable/disposable keg (hereinafter referred to as the "product") of liquid. The cooler/container will allow space for ice to be placed around the product in the cooler/container. The cooler/container will contain an optional plastic saucer as a base to hold the product off the bottom of the cooler/container for allowing a higher cold water level as may needed. The cooler/container will have two openings, one to allow for a tap to the product and a smaller hole for a drain. The larger hole will have a rubber gasket around it which will provide an opening for the tap as well as providing a seal which will deflect the flow of water from around the tap. The smaller hole will house a rubber plug which when released will act as a drain.  When the water in the cooler/container gets to a certain level, the plug can be removed allowing for drainage of water. A vinyl tube that fits into the drain plug can be added to allow controlled drainage of water. This will allow more ice to be added as needed.  A cover is provided to keep the contents in and not exposed to the elements.
Patent CA-2421572-A1 (CA)
Inventor: ROSSMAN EILEEN W
IPC: B66B9/04
Filed: 2003-03-10
Abstract: A self balancing synchronization assembly has a support beam pivotally mounted on a guide rail adjacent a hydraulic elevator jack. A synchronization bracket is pivotally mounted at one end of the beam and a pair of synchronization cables is connected between the bracket and a telescoping part of the jack. A return cable is connected between the other end of the beam and the hoistway pit to balance the load and includes a turnbuckle for retensioning the synchronization cables. A second synchronization bracket can be pivotally mounted at the one end of the support beam to synchronize a three-stage jack.
Patent CA-2422389-A1 (CA)
Inventor: WRIGHT DANIEL R
IPC: A01N57/18
Filed: 2001-09-13
Abstract: Herbicidal compositions are provided which cause rapid symptomology while delivering long term control of regrowth of plants. The herbicidal compositions comprise N-phosphonomethylglycine or a herbicidal derivative thereof, a bipyridilium or a herbicidal derivative thereof, and at least one surfactant. A herbicidal spray composition is preparable from a particulate solid concentrate or a liquid concentrate. Also provided is a method for killing or controlling the growth of plants comprising the step of contacting the foliage of said plants with an aqueous herbicidal composition of the invention.
Patent CA-2422448-A1 (CA)
Title: Packet-based conferencing
Inventor: SIMARD FREDERIC
IPC: H04M3/56
Filed: 2001-09-13
Abstract: Numerous packet-based terminals coupled within a packet-based network can establish a voice conference without the use of a conference bridge if the packet-based terminals can support specific operations. These specific operations include receiving voice data packets from each of the other packet-based terminals within the voice conference, determining a set of talkers within the voice conference and processing the received media data packets appropriately for the selected set of talkers so as to output uncompressed voice signals corresponding to the talkers to a speaker coupled to the packet-based terminal. the removal of the conference bridge can allow the packet-based apparatus to become independent from the packet-based network administration. Further, the removal of the conference bridge allows a reduction in transcoding and hence, allows a better quality signal to be received at the individual apparatus.
Patent CA-2424300-A1 (CA)
Inventor: HAUGLAND RICHARD P
IPC: G01N33/58
Filed: 2001-10-02
Abstract: L'invention concerne des réactifs fluorescents pour la formation de dérivés, qui sont appropriés au couplage avec des biomolécules renfermant des groupes fonctionnels aldéhyde ou cétone. L'invention concerne également un procédé relatif au traitement d'un échantillon par le biais des réactifs considérés. Les réactifs en question sont particulièrement utiles pour le marquage de glycoprotéines ou de glycopeptides, d'acides nucléiques et de lipopolysaccharides dans les gels d'électrophorèse.
Patent CA-2424434-A1 (CA)
Inventor: HANSEN PETER KAMP
IPC: C12N1/15
Filed: 2001-10-12
Abstract: Novel subtilase variants having a reduced tendency towards inhibition by substances present in eggs, such as trypsin inhibitor type IV-0. In particular, variants comprising at least one additional amino acid residue between positions 42-43, 51-56, 155-161, 187-190, 216-217, 217-218 or 218-21 9 (in BASBPN numbering). These subtilase variants are useful exhibiting excellent or improved wash performance on egg stains when used in e.g. cleaning or detergent compositions, such as laundry detergent compositions a nd dishwash composition, including automatic dishwash compositions. Also, isolated DNA sequences encoding the variants, expression vectors, host cells , and methods for producing and using the variants of the invention. Further, cleaning and detergent compositions comprising the variants are disclosed.</ SDOAB>
Patent CA-2426301-A1 (CA)
Inventor: JESKE MARVIN A
IPC: B60P3/12
Filed: 2003-04-09
Abstract: The invention is a device for securing tow lines to a vehicle to allow the vehicle to be moved or recovered from a ditch. The device is designed to secure to and firmly grip the tire and wheel of the vehicle to be moved. It is fashioned as a 'basket-sling' of flexible chain/cable (combination) outside rails with chain and web-strap cross-ties between them to partially enclose the tire. It employs a slider-fink on one end of each chain/cable rail through which the opposite end passes to facilitate tightening (choking) of the 'basket-sling' laterally around the tire.
Patent CA-2426819-A1 (CA)
Inventor: KAUSHAL SUNJAY
IPC: A61K35/12
Filed: 2001-10-30
Abstract: L'invention concerne de nouveaux procédés améliorés et peu vulnérants de synthèse de tissus nécessitant une surface endothéliale, tels que des vaisseaux sanguins et des valvules cardiaques. Ces tissus de synthèse possèdent une perméabilité à long terme. Le procédé est particulièrement approprié dans la fabrication de vaisseaux de faible diamètre destinés à remplacer des vaisseaux sanguins coronaires obstrués ou endommagés, de conduits de valvule cardiaque à trois lames destinés à remplacer des valvules aortiques et pulmonaires présentant une lésion ou une malformation, ainsi que d'autres structures vasculaires nécessitant une surface endothéliale.
Patent CA-2427560-A1 (CA)
Title: Alkynyl amides and their therapeutic applications
Inventor: BENNANI YOUSSEF L
IPC: A61P25/28
Filed: 2001-10-31
Abstract: Compounds of formula (I), are novel and useful for treating seizure, migraine and psychiatric disorders.
Patent CA-2429677-A1 (CA)
Title: Electro-acupuncture device with stimulation electrode assembly
Inventor: MANN THOMAS L
IPC: A61H39/00
Filed: 2001-11-20
Abstract: An electro-acupuncture device (1) for controlling nausea. The device includes a base unit (6) including a wrist-watch like housing, circuitry for generating electro-acupuncture stimulus disposed within the housing and a strap (2) for securing the housing to the wrist. The base unit has a standardized construction. The device also includes a releasably attachable electrode assembly (7). The electrode assembly attaches to the base unit and includes (4) and connectors (12) for connecting the electrodes to the circuitry of the base unit. The output of the device is dependent upon the circuitry of the electrode assembly. The circuitry of the base unit modifies the output of the device depending upon which electrode assembly is attached to the base unit.
Patent CA-2429798-A1 (CA)
Title: Alarm pull-station with camera
Inventor: RIGHT ROBERT W
IPC: G08B13/22
Filed: 2002-09-24
Abstract: A manually operated pull-station for activating an alarm system is provided having a housing which contains a manually activated lever. The lever is moveable between armed and activated positions. In addition, the manually operated pull-station has a camera mounted in the housing.
Patent CA-2431818-A1 (CA)
Inventor: TERSTAPPEN LEON
IPC: G06V20/69
Filed: 2002-01-04
Abstract: L'invention concerne des dispositifs et des procédés destinés à une collecte et à une analyse d'images automatiques, qui permettent l'identification et la classification d'objets microscopiques alignés ou déposés sur des surfaces. Ces objets, p. ex. des cellules cibles rares marquées de façon détectable, sont magnétiquement ou non magnétiquement immobilisés ou soumis à un balayage laser automatisé afin de générer des sous-images ou des images partielles numérisées x-y d'objets cibles ou d'objets non cibles qui sont combinés pour former des images complètes reconstruites, ce qui permet la détection, l'énumération, la différenciation et la caractérisation des objets mis en images sur la base de la taille, de la morphologie et de l'immunophénotype.
Patent CA-2435636-A1 (CA)
Title: Oxide ion conductive ceramic membrane stacked microstructures for high-pressure oxygen production
Inventor: GOURIOU GUYLAINE
IPC: H01M8/12
Filed: 2001-12-18
Abstract: The invention concerns an oxide ion conductive ceramic membrane, characterized in that it comprises a non-null finite volume with non-null total thickness E, comprising, a dense layer (CD) of a solid electrolyte, a so-called bonding layer (CA), of mixed conductive porous cathode (EP) and porous anode (EP'), a cathode current collector (CC) and an anode current collector (CC'), a coating porous layer (ER), and a coating porous layer (ER'), and characterized in that the volume E of said membrane, is equal to the sum of the thickness of said elements. The membrane is used for separating oxygen from air or from a gas mixture containing same and in particular for producing ultra-pure oxygen under high pressure in a closed chamber.
Patent CA-2438711-A1 (CA)
Inventor: MARTIN THOMAS
IPC: A61P37/08
Filed: 2002-02-16
Abstract: Tryptase inhibitors of the formula (I) in which M is a central building block containing two acetylene groups; A1 and A2 are carbonyl containing linking groups; K1 is B3-X1, -B3-Y1 or B3-Z1-B5-X1; K2 is B4-X2, -B4-Y2 or B4-Z2-B6-X2, B3 and B4 are identical or different and are a bond or 1-4C-alkylene; B5 and B6 are identical or different and are a bond of 1-2C-alkylene; X1 and X2 are identical or different and are amino, aminocarbonyl or amidino; Y1 and Y2 are imidazol-1-yl; Z1 and Z2 are identical or different and are 5,2-pyridinylene, 6-methyl-5,2-pyridinylene, 4,1-piperidinylene, 3,6-indazolylene, 3,6-indolylene, 1,3-phenylene, 1,4-phenylene, 1,3-cyclohexylene or 1,4-cyclohexylene.
Patent CA-2439485-A1 (CA)
Title: Process for producing nanometer grade powders
Inventor: LI LIXIANG
IPC: B01D3/36
Filed: 2002-03-05
Abstract: The present invention discloses a process for producing nanometer grade powders, which comprises: (a) providing A and B reactant solutions that can rapidly react to form deposits; (b) respectively suppling A and B solutions to a mixing and reacting precipitator with a stator and a rotor in operation; a nd (c) post-treating the slurry continuously discharge from the precipitator an d containing the deposits. The process is able to controll the size of the nanometer powders, with a uniform particle size, good dispersity and high yield, as well as make the process simple and save the energy. It can be use d to produce various nanometer grade powders of metals, oxides, hydroxides, salts, phosphides, sulfides and organic compounds.
Patent CA-2441095-A1 (CA)
Title: Modified interferon beta with reduced immunogenicity
Inventor: CARR FRANCIS J
IPC: C07K7/08
Filed: 2002-03-15
Abstract: The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of human interferon beta to result in proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.
Patent CA-2441568-A1 (CA)
Title: Pharmaceutical combinations for the treatment of cancer
Inventor: JOLIVET JACQUES
IPC: A61K31/7064
Filed: 2002-03-25
Abstract: In accordance with the present invention there is provided a pharmaceutical combination useful for the treatment of cancer comprising at least one active compound of formula (I): and at least one further therapeutic agent chosen from a nucleoside analogue and/or a chemotherapeutic agents; and, a method of treating a patient having cancer comprising at least one active compound of formula (I), as defined above, and at least one further therapeutic agent chosen from a nucleoside analogue and/or a chemotherapeutic agents.
Patent CA-2441690-A1 (CA)
Title: Method for the identification of antigenic peptides
Inventor: VOGT ANNE
IPC: A61K38/00
Filed: 2003-09-25
Abstract: The present invention relates to methods useful for isolating antigenic peptides from a limited quantity of cells or bodily fluid from a mammalian organism in an amount sufficient to determine their sequence and identity. Therefore this invention relates to methods for identifying novel disease-associated antigens, e.g.  tumor antigens and antigens involved in autoimmune diseases, to be utilized for diagnostic or therapeutic purposes. The methods of the present invention can also be utilized for controlling the quality of vaccines. More specifically, the methods of the invention can be used for determining the sequence of antigenic peptides presented via peptide receptors of dendritic cells which are the most important antigen presenting cells of the body and valuable tools for vaccination.
Patent CA-2441714-A1 (CA)
Inventor: THEIS JOSEPH
IPC: F02D41/02
Filed: 2003-09-19
Abstract: A hydrogen fueled reciprocating spark ignition engine includes a fuel system for providing gaseous hydrogen to the cylinders of the engine and a lean NOx tra p coupled to the engine for treating the engine's exhaust. An EGR system provides recirculated exhaust gas to the engine, and a controller operates the fuel system and EGR system during periodic purging of the lean NOx trap such that the engine is operated fuel rich, with the mass of EGR approximating 40%-80% of the mass of air and fuel.
Patent CA-2442337-A1 (CA)
Title: Gas turbine plant and method of controlling gas turbine plant
Inventor: KOMIYAMA HIROYA
IPC: F02C9/32
Filed: 2001-07-18
Abstract: A gas turbine plant for limiting a sudden increase of load of the gas turbine, i.e., of the amount of fuel, and suppressing a stress of the turbine, or for maintaining a suitable fuel-air ratio is disclosed. The plant includes a controller comprising a section for calculating a governor signal for controlling the degree of opening of the fuel valve, based on a revolution speed of the gas turbine; and a section for calculating a load-limiting signal for following the governor signal, wherein when the governor signal decreases, the load-limiting signal is larger than it by a predetermined value, while when the governor signal increases, the increase rate of the load-limiting signal has a predetermined upper limit. The controller also comprises a limiting section, into which both signals are input, for limiting the upper value of the governor signal by using the load-limiting signal as an upper limit.
Patent CA-2443861-A1 (CA)
Inventor: HAGAI MAKOTO
IPC: H04N19/503
Filed: 2003-04-10
Abstract: The present invention improves efficiency of coding motion vectors when a current block is coded using a plurality of motion vectors. A motion vector coding unit (117) codes a motion vector inputted from a motion vector detecting unit (108). A motion vector for each current block is coded based on a difference between the motion vector and a predicted vector obtained from motion vectors for previously coded neighboring blocks. The predicted vector is generated by one of the following processing: (A) the motion vectors which refer to the same picture are selected from among the motion vectors for the neighboring blocks so as to generate the predicted vector; (B) the motion vectors for the respective neighboring blocks are ordered in the predetermined order, and the motion vectors of the same order rank are selected from the ordered motion vectors so as to generate the predicted vector; and (C) the predicted vector for the second motion vector of the current block shall be the first motion vector, and if the second motion vector and the first motion vector refer to different pictures, the first motion vector is scaled according to the temporal distance between the pictures so as to generate the predicted vector.
Patent CA-2448238-A1 (CA)
Inventor: STRATTON DENNIS A
IPC: A61C13/00
Filed: 2002-01-31
Abstract: L'invention concerne un ensemble d'administration et de mélange (30) de ciment osseux, permettant de mélanger un copolymère en poudre et un monomère liquide pour la formation d'un ciment osseux, et d'administrer celui-ci. Ledit ensemble comprend une cartouche présentant une extrémité distale (34) et une extrémité proximale (36), et définissant une chambre de mélange (40) située entre les extrémités proximale et distale. Un mécanisme de transfert présentant un embout (56) et une tige portant un piston (64) et un piston plongeur est connecté à l'extrémité distale. Ledit mécanisme de transfert comprend un premier mécanisme d'avancement (68) qui permet de faire avancer conjointement le piston et le piston plongeur, et un second mécanisme d'avancement (70) qui permet de déplacer le piston plongeur indépendamment du piston. L'ensemble comprend en outre une poignée amovible (120) présentant une tige permettant de fixer une lame mélangeuse et un raccord à déclenchement rapide (142), et un bouton de déclenchement (144) destiné à bloquer et à débloquer la lame mélangeuse (128) à partir de la poignée amovible.
Patent CA-2449181-A1 (CA)
Title: Method and apparatus for monitoring a railroad hump yard
Inventor: HAWTHORNE MICHAEL J
IPC: G06F17/00
Filed: 2003-11-12
Abstract: A method of monitoring a railroad hump yard, including storing a profile of the hump yard. The commands sent to one or more of the retarding devices and track switches are determined. The telemetry of a car at at least one point after release over the hump is obtained. Finally, the telemetry of the car for the remainder of the path in the hump yard is calculated. The calculated telemetry of the car over the pa th in the hump yard may be displayed real time or may be stored and subsequently displayed. A remote control locomotive device includes operator input, a display, a dat a base of at least a track profile and a program to drive the display with the locatio n of the train on the track profile.
Patent CA-2449506-A1 (CA)
Title: Downhole tool
Inventor: SUSMAN HECTOR FILLIPUS ALEXAND
IPC: E21B4/14
Filed: 2002-05-20
Abstract: There is disclosed a downhole tool for generating a longitudinal mechanical load. In one embodiment, a downhole hammer (10) is disclosed which is activated by applying a load on the hammer and supplying pressurised fluid to the hammer. The hammer includes a shuttle valve (14) and a piston (16) that are moveable between first and further positions, seal faces (18, 20) of the shuttle valve (14) and piston (16) being released when the valve and the piston are in their respective further positions, to allow fluid flow through the tool. When the seal is released, the piston (16) impacts a remainder of the tool to generate a mechanical load. The mechanical load is cyclical by repeated movements of the shuttle valve (14) and piston (16).
Patent CA-2449596-A1 (CA)
Inventor: BLESZYNSKI STANISLAW
IPC: H01P3/16
Filed: 2003-12-05
Abstract: The subject of the invention is a cable-like device called "FiberGuide" that conducts millimeter wave energy from one place to another in a manner similar to a fiber optics cable, with the shield and spacing to ensure the lowest possible loss, plus the methods of interfacing of the said cable-like device to each other as well as to traditional microwave structures such as metallic resonating cavities and metallic waveguides.