Patent SG-11201408511Q-A (SG)
Title: Liquid preparations of amines and organic acids stabilized by salts
Inventor: IKEDA MEGUMI
IPC: A61K47/02
Filed: 2013-06-26
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 3 January 2014 (03.01.2014) WIPOIPCT (10) International Publication Number WO 2014/003199 A1 (51) International Patent Classification: A61K9/00 (2006.01) A61K 47/12 (2006.01) A61K 47/02 (2006.01) A61K 9/08 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 2012-144750 27 June 2012 (27.06.2012) (74) Agent: TAKASHIMA, Hajime; Meiji Yasuda Seimei Osaka Midosuji Bldg., 1-1, Fushimimachi 4-chome, Chuo- ku, Osaka-shi, Osaka 5410044 (JP). PCT/JP2013/068192 26 June 2013 (26.06.2013) English (71) Applicant: TAKEDA PHARMACEUTICAL COM­ PANY LIMITED [ JP/JP] ; 1-1, Doshomachi 4-chome, Chuo-ku, Osaka-shi, Osaka, 5410045 (JP). (72) Inventors: IKED A, Megumi; c/o Astellas Pharma Inc., 180, Ozumi, Yaizu-shi, Shizuoka, 4250072 (JP). HORIU- CHI, Shohei; Westenriederstr. 45/ 3,OG, Munchen, 80331 (DE). SATO, Tomomi; c/o TAKEDA PHARMACEUTIC­ AL COMPANY LIMITED, 17-85, Jusohonmachi 2- chome, Yodogawa-ku, Osaka-shi, Osaka, 5320024 (JP). NAKAI, Shinichiro; c/o TAKEDA PHARMACEUTICAL COMPANY LIMITED, 17-85, Jusohonmachi 2-chome, Yodogawa-ku, Osaka-shi, Osaka, 5320024 (JP). KIY- OSHIMA, Kenichiro; c/o TAKEDA PHARMACEUTIC­ AL COMPANY LIMITED, 17-85, Jusohonmachi 2- chome, Yodogawa-ku, Osaka-shi, Osaka, 5320024 (JP). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, English MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, jp SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) 0\ 0\ i-H m o o o CJ (54) Title: LIQUID PREPARATIONS OF AMINES AND ORGANIC ACIDS STABILIZED BY SALTS (57) Abstract: Provided are liquid a preparation wherein the pharmaceutically active ingredient is stabilized, and stabilizing a meth­ od therefor. A liquid preparation comprising a pharmaceutically active ingredient having a primary or secondary amino group (wherein the amino group does not constitute a part of the amide structure), an organic acid and a salt, which substantially free of is a reaction product of the pharmaceutically active ingredient and the organic acid.