baber/WOPTO huggingface dataset:
Patent DK-2205152-T3 (DK)
Inventor: FREY STEPHAN-MICHAEL
IPC: A61B5/151
Filed: 2008-09-12
Granted: 2012-02-06
Abstract: The invention concerns a disposable device for analyzing body fluid especially for blood sugar tests comprising a container which can be inserted into a measuring apparatus, a sampling member provided in the container to pierce skin of a body part and sample body fluid, and a test member for receiving body fluid obtained by the skin-piercing. According to the invention it is proposed that the test member is fixed in a retaining chamber of the container, and the sampling member is configured in the same retaining chamber such that it is separated at a distance from the test member in an initial state and is in contact with the test member to transfer body fluid in a transfer state after the skin-piercing.
Patent DK-2201840-T3 (DK)
Inventor: HONIGBERG LEE
IPC: A01N43/90
Filed: 2006-12-28
Granted: 2012-02-20
Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
Patent DK-2753646-T3 (DK)
Inventor: ELLMARK PETER BO JOAKIM
IPC: C07K16/28
Filed: 2012-09-05
Granted: 2018-01-02
Abstract: The present invention relates to antibodies (and fragments, variants, fusions and derivatives thereof) with multivalent binding specificity for CD40, which have a potency for dendritic cell activation which is higher than, or is equal to, the potency for B cell activation and wherein the antibody, antigen-binding fragment, or fusion, variant or derivative thereof has an affinity (KD) for CD40 of less than 1x10-10 M, which have utility in the treatment of diseases such as cancer. The invention also relates to pharmaceutical compositions, uses, methods and kits comprising such antibodies.
Patent DK-2895188-T3 (DK)
Inventor: ARAKAWA TSUTOMU
IPC: C07K14/705
Filed: 2013-09-10
Granted: 2018-02-26
Abstract: A mixed mode chromatography method for separating correctly folded from incorrectly folded conformations of a given protein is provided. The method is highly effective in separating correctly folded etanercept from incorrectly folded etanercept and aggregates in commercially attractive yields capable of affording etanercept preparations having very high purity in terms of correctly folded etanercept versus incorrectly folded etanercept. The invention is further directed to protein preparations and formulations comprising correctly folded proteins obtained using the present methods, and methods of treatment using the high purity preparations obtained from the mixed mode method.
Patent DK-3262066-T3 (DK)
Inventor: GROENDAHL CHRISTIAN
IPC: C12N9/64
Filed: 2016-10-27
Granted: 2018-05-22
Abstract: An AAV vector comprising a nucleotide sequence encoding Factor I or a fragment or derivative thereof.
Patent DK-0388954-T3 (DK)
Inventor: MEHRA DEV K
IPC: A61K9/16
Filed: 1990-03-22
Granted: 1995-12-18
Abstract: Freeze-dried polymer latices, which can be reconstituted in water to give aqueous polymer dispersions having high polymer solids content, are described. The reconstituted polymer dispersions are useful in preparing sustained-release drug formulations, particularly of water-soluble drugs, by the wet granulation method without over wetting.
Patent DK-0407995-T3 (DK)
Inventor: PALAZZI CAMILLO MARIA FRANCESC
IPC: A23L33/00
Filed: 1990-07-11
Granted: 1993-04-05
Abstract: Dietetic compositions useful as alimentary integrators containing a mixture of soy natural deacylated phospholipid mixture (glycerophosphoryl-choline, -ethanolamine, -inositol, -serine) are described.
Patent DK-0416426-T3 (DK)
Inventor: CERUTTI PETER A DR PROF
IPC: C12Q1/70
Filed: 1990-08-28
Granted: 1996-03-11
Abstract: The sensitivity of detection of influenza A virus has been considerably increased by carrying out a polymerase chain reaction (PCR) using oligonucleotide sequences (amplimers) from the reasonably conserved region of the viral haemagglutinin gene after previous reverse transcription (RT). The reverse transcription and the PCR are in this case insensitive to single mutations by base exchange unless the 3' end of the amplimers is affected.
Patent DK-0404240-T3 (DK)
Inventor: HOEKSTRA JAN WILLEM
IPC: H02B1/30
Filed: 1990-06-15
Granted: 1994-05-02
Abstract: Snap connection system comprising at least one set of connecting elements (1;1 min :2;2 min ;2 sec ), of which one is fitted on a detachable part (7,8) of an assembly, and the other on a fixed part (10,11) thereof. One connecting element (1;1 min ) is provided with a lobe part (3;3 min ) and being movable resiliently in one direction (B,Bv;B min ,B min v) and rigid in the directions (A,Av;A min ,A min v) at right angles thereto. The other connecting element (2;2 min ;2 sec ) is provided with a catch part (4;4 min ;4 sec ) and being also movable resiliently in a direction (C,Cv;C min ;C sec ) at right angles to the direction (B,Bv;B min ,B min v) in which the connecting element (1;1 min ) provided with the lobe part (3;3 min ) is movable. After connecting the detachable part (7,8) and the fixed part (10,11) of the assembly, the lobe part (3;3 min ) is past the catch part (4;4 min ;4 sec ), when viewed in the connecting direction of the assembly. By moving the connecting element (2;2 min ;2 sec ) with the catch part (4;4 min ;4 sec ) in its resilient direction of movement (C;C min ;C sec ), such that the catch part (4;4 min ;4 sec ) lies totally clear of the lobe part (3;3 min ), said lobe part (3;3 min ) act as a blocking element for the catch part (4;4 min ;4 sec ) until the one connecting element (1;1 min ) is removed from the other connecting element (2;2 min ;2 sec ). Provisions (9;12,13;13 min ) are made for moving the connecting element (2;2 min ;2 sec ) with the catch part (4;4 min ;4 sec ) by a screw driver from the outside of the detachable part (7,8).
Patent DK-0396460-T3 (DK)
Inventor: PERSELLO JACQUES
IPC: A61K8/00
Filed: 1990-04-27
Granted: 1992-11-16
Abstract: Silica compatible with metal ions such as zinc, tin or strontium, characterised by a surface OH<-> number expressed as OH<->/nm<2> lower than or equal to 10, a zero charge point (ZCP) of between 3 and 6.5 and resulting in an aqueous suspension whose pH varies as a function of its electrical conductivity according to the equation  - pH = b - a log (D), in which  a is a constant lower than or equal to 0.6,  b is a constant lower than or equal to 8.5 and (D) represents the electrical conductivity of the aqueous suspension of silica, expressed in microsiemens cm<-><1>. Process for preparing the silica, consisting in reacting a silicate with an acid, thus resulting in a silica suspension or gel, in performing a first aging at a pH higher than or equal to 6 and lower than or equal to 8.5, then a second aging at a pH lower than or equal to 5.0, in separating off the silica, in subjecting it to washing with hot water until it produces an aqueous suspension whose pH measured on a suspension containing 20 % of SiO2 obeys the equation  - pH = d - c log (D> in  which c is a constant lower than or equal to 1.0,  d is a constant lower than or equal to 8.5 and (D) denotes the electrical conductivity of the aqueous suspension of silica, expressed in microsiemens cm<-><1>; and finally in drying it.   Dentifrice composition containing the silica described.
Patent DK-0446832-T3 (DK)
Inventor: ANZEVENO PETER B
IPC: C07D493/14
Filed: 1991-03-11
Granted: 1996-07-01
Abstract: Castanospermine (I) is prepared by starting from 5-(t-BOC)amino-5-deoxy-1,2-O-isopropylidene- alpha -D-glucuronolactone. Two additional carbons are added to the starting material using ethyl acetate and a strong base and the resulting cyclic hemiketal is subjected to a series of reductions, with intervening removal of protecting groups, to give the castanospermine. A substituted hydroxypyrrolidinone and a substituted hydroxypyrrolidine serve as intermediates in the process. <CHEM> -
Patent DK-0457163-T3 (DK)
Inventor: BAADER EKKEHARD DR
IPC: A61K31/198
Filed: 1991-05-07
Granted: 1994-10-17
Abstract: The invention relates to oxalylamino acid derivatives of the formula I  <IMAGE>  in which R and R' are identical or different and are C1-C6 -alkyl or hydrogen, R1 is hydrogen or C1-C4-alkyl, R2 is hydrogen, C1-C6-alkyl, C1-C3-alkoxy, carboxyl, C1-C6-alkoxycarbonyl, aryl, SH, NH2 or halogen, where the alkyl radicals are unsubstituted or substituted by aryl, OH, SH or NH2  or R1 and R2 together are a C2-C4-alkylene chain and the compounds in their predominantly pure D- and L-form and the physiologically tolerable salts. The compounds are distinguished as excellent inhibitors of prolyl hydroxylase and lysine hydroxylase.
Patent DK-0475030-T3 (DK)
Inventor: FARWER ALFWARD DR
IPC: B23K35/38
Filed: 1991-08-20
Granted: 1995-03-13
Abstract: The inert gas used in the TIG and MIG welding of aluminium is as pure as possible argon or as pure as possible mixtures of argon and helium. In order to improve the welding operation and the welding result, 80 vpm to 250 vpm, preferably 120 vpm to 180 vpm, of nitrogen are added to the inert gas.
Patent DK-0537377-T3 (DK)
Inventor: WOESTE ALBRECHT DIPL-ING
IPC: F16L47/24
Filed: 1991-10-17
Granted: 1995-10-02
Abstract: The invention relates to a pipe connection for gas pipes and water pipes, between a metal pipe end and a plastic pipe end. A connection which is permanently and reliably sealed and is corrosion-resistant between metal pipe ends and plastic pipe ends is formed in that a bell-like metal collar (4) is arranged in a sealed manner on the end of the metal pipe (2) in such a manner that an annular space (5) is formed between the larger internal diameter of the collar (4) and the end (3), which projects into the collar (4), of the metal pipe (2), in which annular space (5) a sealing ring (6) is arranged, and in that a collar-like injection moulding (9), which encloses the collar (4) of the metal pipe (2), is integrally formed on the end of the plastic pipe (1), the free internal diameter (10) of which injection moulding (9) corresponds to the internal diameter of the pipes (1, 2), and the external diameter of which injection moulding (9) is larger than the external diameter of the bell-like collar (4), the thermoplastic material of the injection moulding (9) filling the space between the free internal diameter (10) and the internal diameter of the bell-like collar (4), causing the sealing ring (6) to be prestressed. <IMAGE>
Patent DK-0524972-T3 (DK)
Inventor: BELDOCK DONALD T
IPC: A61Q17/02
Filed: 1991-03-19
Granted: 1995-10-02
Abstract: An insect repellent is provided and includes turpeniol, citronella, and one or both of rhodenol extract and geraniol as actives provided in a conveying medium. The actives are used in small percentages, e.g. as little as .01 %, preferably at between .05 % and .08 %, and preferably less than 1 %, yet are synergistically efficacious, particularly against ticks carrying Lyme disease. The conveying medium can be a cosmetic moisturizer lotion, with or without a sun screen. For a spray, the conveying medium can be water or alcohol based. An attractive fragrance is preferably provided as approximately .4 % of the insect repellent. The lotion or spray is safely applied in liberal quantities to humans and animals without unpleasant side effects such as stinging.
Patent DK-0553263-T3 (DK)
Inventor: MALAMAS MICHAEL SOTIRIOS
IPC: A61P25/00
Filed: 1991-10-10
Granted: 1999-05-10
Abstract: This invention relates to 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones of structural formula (I)   <IMAGE> (I)  wherein: R1 and R2 are independently hydrogen, alkyl containing 1 to 6 carbon atoms, halogen, lower alkoxy containing 1 to 6 carbon atoms, trifluoromethyl, nitro, aryl or aryl(lower alkyl)oxy wherein aryl contains 6 to 10 carbon atoms and lower alkyl contains 1 to 6 carbon atoms; R3 is lower alkyl containing 1 to 6 carbon atoms, aryl, aryl(lower alkyl) or dihalogen substituted aryl (lower alkyl) wherein aryl contains 6 to 10 carbon atoms and lower alkyl contains 1 to 6 carbon atoms; R4 and R5 are independently hydrogen, alkyl containing 1 to 6 carbon atoms, aryl or aryl (lower alkyl) wherein aryl contains 6 to 10 carbon atoms and lower alkyl contains 1 to 6 carbon atoms, alkanoyl wherein alkyl contains 1 to 5 carbon atoms, carboalkoxy, wherein alkyl contains 1 to 6 carbon atoms, alkylsulfoxy, arylsulfoxy, alkylsulfonyl, or arylsulfonyl wherein alkyl contains 1 to 6 carbon atoms and the pharmaceutically acceptable salts thereof when R4 and R5 are hydrogen, alkyl or aryl to processes for their preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for the prevention or treatment of diabetes mellitus associated complications.
Patent DK-0545582-T3 (DK)
Inventor: ANDERSON DAVID BENNETT
IPC: A23K1/16
Filed: 1992-11-19
Granted: 1996-09-16
Abstract: This invention is directed to the use of the compound ractopamine for improved production of fish.
Patent DK-0541420-T3 (DK)
Inventor: BRINDEL PATRICK
IPC: H01S5/06
Filed: 1992-10-26
Granted: 1995-12-04
Abstract: A laser (4) is polarised in the neighbourhood of the kink (8) in its characteristic curve (6). It furthermore receives, in electrical form, a base wave applied to an input (14) of the generator and a local wave provided by a local oscillator (16) and it mixes these waves while adding their frequencies in order to modulate the light wave which it emits. 
<??>The invention finds particular application in telecommunications systems. 
<IMAGE>
Patent DK-0625164-T3 (DK)
Inventor: DEGRADO WILLIAM FRANK
IPC: A61K38/00
Filed: 1992-09-30
Granted: 1999-10-18
Abstract: This invention relates to novel cyclic compounds containing carbocyclic ring systems useful as antagonists of the platelet glycoprotein IIb/IIIa complex, to pharmaceutical compositions containing such cyclic compounds, and to methods of using these compounds for the inhibition of platelet aggregation.
Patent DK-0610357-T3 (DK)
Inventor: LIPP RALPH
IPC: A61K31/56
Filed: 1992-10-21
Granted: 1998-05-11
Abstract: Described is a transdermal therapeutic system which is characterized in that it includes a crystallization inhibitor, and optionally also penetration enhancers, in an adhesive matrix containing the active substance.
Patent DK-0567323-T3 (DK)
Inventor: GARDNER JOHN PAUL
IPC: C07D501/06
Filed: 1993-04-21
Granted: 1999-12-13
Abstract: The invention relates to an improved process for preparing cephalosporins by reaction compounds such as 7-amino -cephalosporanic acid, 7-amino-3-deacetoxy-cephalosporanic acid or their derivatives with derivatives of  alpha -amino acids in the presence of a properly immobilized penicillin acylase enzyme under the following conditions, independently, or in combination: (1) at a temperature ranging from 0 DEG C to +20 DEG C; or (2) at ambient pH; with a high molar ratio of ( alpha -amino acid to a cephalosporanic nucleus.
Patent DK-0639364-T3 (DK)
Inventor: INOUE FUJIO
IPC: B65D81/32
Filed: 1993-04-28
Granted: 1999-11-29
Abstract: A vessel having a plurality of chambers for use mainly in the medical field, wherein the interior of the main body of a flexible plastic vessel is partitioned into a plurality of chambers by use of a partitioning means permitting suitable communication between the chambers, out of respective vessel portions of the main body of the plastic vessel, which constitute the plurality of chambers, at least one vessel portion has no cover and at least another vessel portion has a cover, said cover covering the peripheral surface of said vessel portion through a tightly sealed space portion and being formed of flexible film having moisture-proof and gas barrier properties, so that the easily disposable vessel having the plurality of chambers, which is inexpensive and high in quality and performance can be provided. <IMAGE>
Patent DK-0610661-T3 (DK)
Inventor: LEFFER MICHAEL
IPC: B09B1/00
Filed: 1994-01-10
Granted: 1997-05-05
Abstract: A method of compacting a dump of old precompressed waste and of obtaining a supplementary receiving capacity for new waste, in which a displacement body is sunk in the dump by the solid displacement method for the purpose of forming a cavity, is then withdrawn, and the resulting cavity is filled with new waste and the latter is compacted with the use of a drop weight, uses a device in which a pipe (2) having a threaded tip (3) is used as the displacement body. The pipe (2) is screwed into the dump (20, 21) while rotating about a vertical axis (x-x) and under the action of axial thrust forces. <IMAGE>
Patent DK-0645451-T3 (DK)
Inventor: GLUZMAN YAKOV
IPC: C12R1/19
Filed: 1994-09-09
Granted: 2001-10-08
Abstract: Structural analogues of fibroblast growth factors have at least one point mutation in a heparin binding site. Typical point mutations are deletions or replacements of basic residues with other residues, e.g., neutral or acidic residues. In some embodiments, the analogues have at least one point mutation in a heparin binding site. Preferred analogues have one or two basic residues replaced by glutamine, and exhibit a binding affinity to cell surface receptors similar or superior to native growth factor, but different heparin binding and biological activity from the native growth factor.
Patent DK-0629160-T3 (DK)
Inventor: DELTOMME MARC
IPC: B60P1/64
Filed: 1994-01-13
Granted: 1997-10-27
Abstract: A device (1) for mounting on the chassis of a road transport or handling vehicle (39), comprising an assembly for handling and supporting a container (29), including a tipper (17) and a tilting arm (11) as well as a coupling assembly (21) for a semi-trailer (27), including a fifth wheel (21) receiving a semi-trailer kingpin.
Patent DK-0719328-T3 (DK)
Inventor: SCHWEIGHOFFER FABIEN
IPC: A61K48/00
Filed: 1994-05-09
Granted: 2000-11-13
Abstract: The present invention relates to the Grb3-3 protein, nucleotide sequence encoding this protein, and variants thereof, such as antisense sequences. The invention further relates to vectors comprising these sequences and to methods for inducing cell death.
Patent DK-0658542-T3 (DK)
Inventor: TAKASE AKIRA
IPC: C07C255/64
Filed: 1994-07-01
Granted: 1998-04-06
Abstract: A process for producing an  alpha -hydroxyiminophenylacetonitrile represented by general formula [II], (wherein R<1>, R<2>, R<3> and Z are each as defined in the specification) by reacting a crude nitrile containing a phenylacetonitrile represented by general formula [I], (wherein R<1>, R<2>, R<3> and Z are each as defined in the specification) with an alkyl nitrite in the presence of a base, extracting the reaction mixture with water, and neutralizing the separated water layer with an acid. This process enables target alpha -hydroxyiminophenylacetonitriles to be readily produced in a highly pure form in high yield by extracting the reaction mass with water and neutralizing the separated water layer with an acid. <CHEM>
Patent DK-0666252-T3 (DK)
Inventor: SCHOLZ WOLFGANG DR
IPC: C07C279/22
Filed: 1995-01-19
Granted: 2003-01-27
Abstract: Perfluoroalkyl-substd. phenylalkanoic acid guanidides of formula (I) and their salts are new: Ra, Rb = H, halogen, CN, OR6, 1-8C alkyl, 3-8C cycloalkyl, Or(CH2)aCbF2b+1 or NR7R8; r = 0 or 1; a = 0-4; b = 1-8; R6-R8 = H, 1-8C alkyl, 3-8C alkenyl, 3-8C cycloalkyl, or phenyl or benzyl opt. substd. by 1-3 of F, Cl, CF3, Me, OMe and NR9R10; R9, R10 = H, 1-4C alkyl or 1-4C perfluoroalkyl; x = 1-3; R1-R5 = H, 1-8C alkyl, 3-8C cycloalkyl, Or(CH2)aCbH2b+1, halogen or CN; provided that ≥ 1 of R1-R5, Ra and Rb = Or(CH2)aCbH2b+1.
Patent DK-0741146-T3 (DK)
Inventor: FUSCO ROBERTO
IPC: C08F4/6592
Filed: 1996-04-22
Granted: 2000-10-02
Abstract: An improved process for ethylene (co)polymerization is carried out in the presence of a catalyst obtained by reacting a Ziegler-Natta catalyst, or a component thereof, wherein at least a transition metal is  pi -bonded to an organic residue, with an alpha-olefin having the following general formula (II): <CHEM> wherein R<4> and R<5> are two substituents selected, independently, from linear, cyclic or branched aliphatic or aromatic hydrocarbon groups having from 1 to 12 carbon atoms, or they are linked to each other to form a substituted or non-substituted cyclic compound, comprising the vinyl carbon atom in a ring of from 3 to 8 carbon atoms. The polymerization process allows productivity values to be obtained which are higher than those obtained with an analogous process carried out without the preliminary interaction with the above said alpha-olefin, while simultaneously allowing a complete freedom with regard to the choice of the monomer composition.
Patent DK-0727143-T3 (DK)
Inventor: KNIEL BAERBEL
IPC: A21D/
Filed: 1996-01-22
Granted: 2000-10-30
Abstract: Improver compositions for baked goods, which are free of cysteine but do have the properties of a cysteine containing composition comprise:  5 - 50 wt% of a sugar  1 - 20 wt% of an emulsifier  1 - 12 wt% of dough stabilizer  0.05 - 2.5 wt% of enzymen  0.1 - 1.0 wt% of chemical oxidative agent 0.1 - 10 wt% of a rye fine fraction
Patent DK-0961557-T3 (DK)
Inventor: THOMAS TOBY R
IPC: B65D33/25
Filed: 1997-10-22
Granted: 2003-02-17
Abstract: A reclosable plastic bag comprises first and second opposing body panels, a zipper, a slider, and first and second upstanding panels. The opposing body panels are fixedly connected to each other along a pair of sides and a bottom bridging the pair of sides. The zipper extends along a mouth formed opposite the bottom. The zipper includes a first track with a first profile and a second track with a second profile. The first and second profiles are releasably engageable to each other. The slider is slidably mounted to the zipper for movement between a closed position and an open position. The first and second profiles are engaged to each other while the slider is in the closed position, and the first and second profiles are disengaged from each other in response to movement of the slider from the closed position to the open position. The first and second upstanding panels extend upwardly from the respective first and second body panels. Each of the upstanding panels includes opposing ends, and the opposing ends of the first upstanding panel are connected to the respective opposing ends of the second upstanding panel to form an open pocket in which the slider and zipper are captured. The open pocket may be sealed by joining the first and second upstanding panels to each other above the slider so as to completely encapsulate the slider within the pocket.
Patent DK-0921928-T3 (DK)
Inventor: NAHILL THOMAS E
IPC: B29B11/08
Filed: 1997-08-18
Granted: 2003-03-10
Abstract: A method of reducing uncontrolled flow of a molten polymer during the packing and cooling stage of an injection molding cycle, wherein a plurality of polymers are injected between a mold cavity and core for making a multi-layer plastic article having upper and lower regions and a tapered region there between which decreases in wall thickness as it approaches the upper region, wherein during the molding cycle at least one first polymer is injected to form an exterior layer and at least one second polymer is injected to form an interior layer, and wherein the second polymer forms a flow front having a leading/trailing edge, the method comprising the step of: selecting the width of the tapered region, as defined between the mold cavity and core, such that the interior layer extends substantially up to the upper region at all points around the circumference and the second polymer does not reverse flow during the packing and cooling stage. <IMAGE>