Patent SG-11201804884P-A (SG)
Title: Method for modulating autophagy and applications thereof
Inventor: MANJITHAYA RAVI
IPC: A61K31/277
Filed: 2016-12-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11 M1111101110101011111 HO 11111 0101101HEIM1100 1111111110111011# International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ..... .....!;,' WO 2017/098467 Al 15 June 2017(15.06.2017) WIPO I PCT (51) International Patent Classification: Aravinda; Autophagy lab, Molecular Biology and Genet- A61K 31/277 (2006.01) A61K 31/443 (2006.01) ics Unit, Jawaharlal Nehru Centre for Advanced Scientific A61K 31/325 (2006.01) A61P 25/00 (2006.01) Research, Jakkur, Bangalore 560064 (IN). A61K 31/352 (2006.01) A61P 25/28 (2006.01) A61K 31/4025 (2006.01) A61P 25/16 (2006.01) (74) Agents: MUKHARYA, Durgesh et al.; K&S Partners, 4121/B, 6th Cross, 19A Main, HAL II Stage (Extension), (21) International Application Number: Bangalore Karnataka 560 038 (IN). PCT/IB2016/057498 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: 9 December 2016 (09.12.2016) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (26) Publication Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (30) Priority Data: 6596/CHE/2015 9 December 2015 (09.12.2015) IN MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (71) Applicant: JAWAHARLAL NEHRU CENTRE FOR RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. ADVANCED SCIENTIFIC RESEARCH [IN/IN]; Jakkur, Karnataka, Bangalore 560064 (IN). (84) Designated States (unless otherwise indicated, for every (72) Inventors: MANJITHAYA, Ravi; Autophagy lab, Mo- _ lecular Biology and Genetics Unit, Jawaharlal Nehru kind of regional protection available): ARIPO (BW, GH, Centre for Advanced Scientific Research, Jakkur, Ban- galore 560064 (IN). MISHRA, Piyush; Autophagy lab, Molecular Biology and Genetics Unit, Jawaharlal Nehru GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, — _ _ Centre for Advanced Scientific Research, Jakkur, Ban- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: = galore 560064 (IN). SANTHI NATESAN, Suresh; Auto- phagy lab, Molecular Biology and Genetics Unit, Jawa- harlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064 (IN). BATS, Somya; Auto- = = lab, Molecular Biology and Genetics Unit, Jawa- phagy harlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064 (IN). AMMANATHAN, of inventorship (Rule 4.17(iv)) Published: Veena; Autophagy lab, Molecular Biology and Genetics = Unit, Jawaharlal Nehru Centre for Advanced Scientific Re- with international search report (Art. 21(3)) = search, Jakkur, Bangalore 560064 (IN). CHAVALMANE, = = = = = = 1-1 IN 7r GC t:t © IN 1-1 (54) Title: METHOD FOR MODULATING AUTOPHAGY AND APPLICATIONS THEREOF 0 ei (57) : The present disclosure relates to method of modulating autophagy by modulators of autophagy, wherein the auto - en. ) phagy includes but is not limited to macroautophagy, chaperone mediated autophagy and microautophagy. The present disclosure further relates to modulators of autophagy for increasing or decreasing the autophagic flux. The disclosure also relates to modulator per se in modulating autophagy including but not limiting to macroautophagy, chaperon mediated autophagy and microautophagy.