Patent SG-11201908553S-A (SG)
Title: Combination of isoindolinone derivatives with sgi-110
Inventor: CHESSARI GIANNI
IPC: A61K31/4035
Filed: 2018-03-28
Abstract: International Publication Date (19) World Intellectual Property Organization International Bureau (10) International Publication Number WO 2018/178679 Al °mono n o VII IE (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) 04 October 2018 (04.10.2018) WIPO I PCT (51) International Patent Classification: (72) Inventors: CHESSARI, Gianni; c/o Astex Therapeutics C07D 401/06 (2006.01) C07D 405/12 (2006.01) Limited, 436 Cambridge Science Park, Milton Road, Cam- A61K 31/4035 (2006.01) CO7H 19/207 (2006.01) bridge Cambridgeshire CB4 OQA (GB). LYONS, John A61K 31/708 (2006.01) C07C 403/12 (2006.01) Francis; c/o Astex Therapeutics Limited, 436 Cambridge C07D 403/06 (2006.01) C07D 209/46 (2006.01) Science Park, Milton Road, Cambridge Cambridgeshire C07D 405/06 (2006.01) A61P 35/00 (2006.01) CB4 OQA (GB). C07D 405/10 (2006.01) (74) Agent: ELKINGTON AND FIFE LLP; Thavies Inn (21) International Application Number: PCT/GB2018/050832 (22) International Filing Date: 28 March 2018 (28.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1704966.9 28 March 2017 (28.03.2017) GB (71) Applicants: ASTEX THERAPEUTICS LIMITED [GB/GB]; 436 Cambridge Science Park, Milton Road, Cambridge Cambridgeshire CB4 OQA (GB). CANCER RESEARCH TECHNOLOGY LIMITED [GB/GB]; An- gel Building, 407 St John Street, London Greater London EC1V 4AD (GB). House, 3-4 Holborn Circus, London Greater London EC1N 2HA (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, W O 20 18/ 17 867 9 Al (54) Title: COMBINATION OF ISOINDOLINONE DERIVATIVES WITH SGI-110 (10) (57) : The invention provides a combination comprising: (i) a com- pound of formula (Io) : (Io) or a tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims; and (ii) a compound which is SGI-110 (SGI-110) or a tautomer or a solvate or a pharmaceutically acceptable salt thereof. Also provided are phar- maceutical compositions containing the combinations and medical uses of the combinations. (SGI-110) [Continued on next page] WO 2018/178679 Al MIDEDIMOIMEMIEHNOMOIMIIMICHMEMOIMIE TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3))