Patent SG-11201804674U-A (SG)
Title: Heteroarylhydroxypyrimidinones as agonists of the apj receptor
Inventor: MYERS MICHAEL C
IPC: C07D417/14
Filed: 2016-12-15
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau 1111111111111111111111111111111111111111111111111111111111111111111111111111R111111111111111 (10) International Publication Number WO 2017/106396 Al WIPO I PCT (43) International Publication Date 22 June 2017 (22.06.2017) (51) International Patent Classification: pany, 311 Pennington Rocky Hill Road, Pennington, New C07D 413/14 (2006.01) C07D 417/14 (2006.01) Jersey 08534 (US). PI, Zulan; c/o Bristol-Myers Squibb C07D 403/04 (2006.01) A61K 31/513 (2006.01) Company, 311 Pennington Rocky Hill Road, Pennington, C07D 413/04 (2006.01) A61P 9/00 (2006.01) New Jersey 08534 (US). BRIGANCE, Robert Paul; 28 (21) International Application Number: PCT/US2016/066750 nington Rocky Hill Road, Pennington, New Jersey 08534 Lakeside Drive, Levittown, PA 19054 (US). FINLAY, Heather; c/o Bristol-Myers Squibb Company, 311 Pen- (US). (22) International Filing Date: 15 December 2016 (15.12.2016) et al.; Bristol-Myers (74) Agents: JACOBSEN, Barry H. Squibb Company, Route 206 and Province Line Road, English (25) Filing Language: Princeton, New Jersey 08543 (US). English (26) Publication Language: (81) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of national protection available): AE, AG, AL, AM, 62/267,997 16 December 2015 (16.12.2015) US AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, [US/US]; Route 206 and Province Line Road, Princeton, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, New Jersey 08543 (US). KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (72) Inventors: MYERS, Michael C.; c/o Bristol-Myers MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, Squibb Company, 311 Pennington Rocky Hill Road, Pen- NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, nington, New Jersey 08534 (US). LAWRENCE, R. Mi- RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, chael; c/o Bristol-Myers Squibb Company, 311 Penning- TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ton Rocky Hill Road, Pennington, New Jersey 08534 (US). ZA, ZM, ZW. BILDER, Donna M.; c/o Bristol-Myers Squibb Company, (84) Designated States (unless otherwise indicated, for every 311 Pennington Rocky Hill Road, Pennington, New Jersey kind of regional protection available): ARIPO (BW, GH, 08534 (US). MENG, Wei; c/o Bristol-Myers Squibb Com- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, [Continued on next page] (54) Title: HETEROARYLHYDROXYPYRIMIDINONES AS AGONISTS OF THE APJ RECEPTOR (57) : The present invention provides com- pounds of Foiinula (I): wherein all variables are as defined in the specification, and compositions com- prising any of such novel compounds. These com- pounds are APJ agonists which may be used as medicaments, in particular for treating cardiovascular disorders. N OH (alk) 0 _ 2 001-4 W O 20 17 / 106396 Al (I) WO 2017/106396 Al MIDEDItitiMIRDEZHEMIHIEBRIERUDIMIE TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) of inventorship (Rule 4.17(iv)) Published: Declarations under Rule 4.17: with international search report (Art 21(3)) as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii))