baber/WOPTO huggingface dataset:
Patent FI-20050753-A0 (FI)
Inventor: STENMAN ULF-HAAKAN
IPC: C07K/
Filed: 2005-07-14
Abstract: Isolated peptide comprising an amino acid sequence selected from SRFKVWWAAG (SEQ ID NO:55), ARFKVWWAAG (SEQ ID NO:56), SAFKVWWAAG (SEQ ID NO:57), SRFKAWWAAG (SEQ ID NO:60), SRFKVAWAAG (SEQ ID NO:61), SRFKVWAAAG (SEQ ID NO:62), SRFKVWWAAG (SEQ ID NO:63), SRFKVWWAAG (SEQ ID NO:64), RFKVWWAAG (SEQ ID NO:65), SRFKVWWAG (SEQ ID NO:68), SRFKVWWG (SEQ ID NO:69), or from SRFKVWWG (SEQ ID NO:73), SRFKVWWG (SEQ ID NO:74), ARFKVWWG (SEQ ID NO:75), ARFKVWWG (SEQ ID NO:76), ARFKVWWGG (SEQ ID NO:77), ARFKVWWGG (SEQ ID NO:78), ARFKVWWA (SEQ ID NO:79), ARFKVWWA (SEQ ID NO:80), ARFKVWWAA (SEQ ID NO:81) and ARFKVWWA(CONH 2 ) (SEQ ID NO:82), or an amino acid sequence, which is SRFKVWWAAG (SEQ ID NO:1. The novel peptides are capable of binding to human kallikrein 2 and of inhibiting the proteolytic activity of human kallikrein 2. They can be used in prostate cancer treatment as such or in combination with other ligands modulating the activity of factors mediating tumor growth.
Patent IL-104567-A0 (IL)
Title: Ethanolamine derivatives,processes for the preparation thereof and a pharmaceutical composition containing the same
IPC: A61K31/4245
Filed: 1993-01-31
Abstract: This invention relates to new ethanolamine derivatives having gut selective sympathomimetic and anti-pollakiuria activities and represented by the general formula [I]:    <IMAGE>  [I]  wherein R1 is aryl or a heterocyclic group, each of which may be substituted with halogen, etc., R2 is hydrogen, halogen, nitro, hydroxy, lower alkyl optionally substituted with acyl, lower alkenyl optionally substituted with acyl, lower alkoxy optionally substituted with acyl, or amino optionally substituted with acyl(lower)alkyl, R3 is hydrogen, an N-protective group, or lower alkyl optionally substituted with lower alkylthio, n is an integer of 0 to 3, and a heavy solid line means a single bond or a double bond, provided that when n is 1, then 1) R1 is a condensed aromatic hydrocarbon group or a heterocyclic group, each of which may be substituted with halogen, etc., and the like, and pharmaceutically acceptable salts thereof to processes for the preparation thereof and to a pharmaceutical composition comprising the same.
Patent IL-109926-A0 (IL)
Title: Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
IPC: C12R1/01
Filed: 1994-06-07
Abstract: An enzymatic hydrolysis method, wherein one or more C-10 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. Also provided is an enzymatic esterification method, wherein one or more C-10 hydroxyl-bearing taxanes are contacted with an acylating agent and an enzyme or microorganism capable of esterifying said hydroxyl groups to form acyloxy groups. Further provided is an enzymatic hydrolysis method, wherein one or more C-13 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. The methods are especially useful for the preparation of compounds which may be employed as intermediates in the preparation of taxanes such as taxol.
Patent IL-110798-A0 (IL)
Title: Corticosteroid 17-alkyl carbonate 21-(0)-carboxylic and carbonic esters, processes for their preparation, and pharmaceuticals containing these compounds
IPC: C07J43/00
Filed: 1994-08-28
Abstract: There are described 17-alkyl carbonate-21-carbonic/carboxylic acid esters of corticosteroids of the formula I <IMAGE> where A is CHOH or CHCl, CH2, C = O, a 9(11) double bond; Y is H, F, Cl; Z is H, F, CH3; R(1) is aryl, hetaryl; n and m are zero or 1; R(2) is alkyl, -(CH2)2-OCH3; R(3) is H, methyl. They are obtained by reacting a compound of the formula II <IMAGE> in which R(5) is OH, with an activated carboxylic acid of the formula III  R(6)-CO-(O)n-[(C1-C4)-alkyl]m-R(1)      III The compounds I have very potent local and topical anti-inflammatory activity and show a very good ratio of local to systemic anti-inflammatory action, which is often clearly superior compared with analogous corticoid 17-alkyl carbonate 21-esters which do not carry an aryl or hetaryl group in the 21 ester radical.
Patent IL-115335-A0 (IL)
Title: Naphthyl compounds intermediates processes compositions and methods
IPC: C07C211/19
Filed: 1995-09-18
Abstract: The present invention provides a compound of formula I <CHEM>  wherein R<1> is -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl), or -OSO2(C4-C6 alkyl); R<2> is -H, -OH, -O(C1-C4 alkyl), -OCOC6H5, -OCO(C1-C6 alkyl) or -OSO2(C4-C6 alkyl);     n is 2 or 3; and R<3> is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino, dimethylamino, diethylamino, or 1-hexamethyleneimino;  or a pharmaceutically acceptable salt thereof. The compounds are useful for treating diseases such as post-menopausal syndrome, and uterine fibroid disease, endometriosis, and aortal smooth muscle cell proliferation.
Patent IL-123641-A0 (IL)
Title: Circular dna molecule with conditional origin of replication method for preparing the same and use thereof in gene therapy
IPC: C12N15/00
Filed: 1996-09-13
Abstract: A novel circular DNA molecule (I), useful in gene therapy, comprises >= 1 sequence of interest, the replication of which is controlled by an origin of replication (ORI) from a plasmid or bacteriophage, which is only active in a host cell in the presence of one or more specific proteins foreign to that cell.
Patent IL-138060-A0 (IL)
Title: C-myc coding region determinant-binding protein (crd-bp)
IPC: G01N33/574
Filed: 1999-03-05
Abstract: A method of diagnosing the presence or absence of cancer in a human patient is disclosed. In one embodiment, this method comprises the steps of examining patient tissue for the CRD-BP expression levels and comparing that expression level with control levels. The present invention is also a method of inhibiting cancer cell growth comprising the step of eliminating or lowering the level of functional CRD-BP in the cancerous tissues.
Patent IL-142743-A0 (IL)
Title: Liquid composition with fungicidal, bactericidal and bacteriostatic activity
IPC: A01N65/06
Filed: 1999-08-24
Abstract: The invention concerns a phytosanitary fungicide, bactericidal or bacteriostatic composition comprising at least a mineral salt, a copper oxide or hydroxide suspended in an aqueous emulsion of at least a terpene derivative.
Patent IL-147767-A0 (IL)
Title: Processes for the preparation of 2-arylvinyl alkyl ether and 1,4-diaryl-2-fluoro-2-butene compounds
IPC: C07C41/06
Filed: 2000-08-07
Abstract: An improved process for the preparation of 2-arylvinyl alkyl ether compounds of the structural formula IIn addition, the present invention provides an improved process for the preparation of 1,4-diaryl-2-fluoro-2-butene compounds of the structural formula V
Patent IL-161628-A0 (IL)
Title: Pharmaceutical dosage form with multiple coatings
IPC: A61K45/00
Filed: 2004-04-26
Abstract: The present invention relates to a pharmaceutical composition in a solid unit dosage form for oral administration in a human or lower animal comprising: a. a safe and effective amount of a therapeutically active agent; b. an inner coating layer selected from the group consisting of poly(methacrylic acid, methyl methacrylate) 1:2, poly(methacrylic acid, methyl methacrylate) 1:1, and mixtures thereof; and c. an outer coating layer comprising an enteric polymer or film coating material; wherein the inner coating layer is not the same as the outer coating layer; wherein if the inner coating layer is poly(methacrylic acid, methyl methacrylate) 1:1 then the outer coating layer is not poly(methacrylic acid, methyl methacrylate) 1:2 or is not a mixture of poly(methacrylic acid, methyl methacrylate) 1:1 and poly(methacrylic acid, methyl methacrylate) 1:2; and wherein the inner coating layer and the outer coating layer do not contain any therapeutically active agent. This invention further relates to a method of maintaining the desired site of delivery of a therapeutic agent in the gastrointestinal tract by administering the above compositions to a human or lower animal.
Patent IL-174946-A0 (IL)
Title: Formats for optical analysis and methods of manufacturing the same
IPC: G01N21/03
Filed: 2006-04-11
Abstract: Formats for the optical testing of fluids are manufacturing using modular format components. The format components are constructed so that matching format components can be mated together to form a single format for optical testing. Formats may be manufactured using pin-and-hole construction so that pins on optical format components mate with holes on opposing format components. Optical read surfaces provided on optical format components oppose each other in a completed optical format to form a read area.
Patent IL-177160-A0 (IL)
Title: Method and circuit for generating random numbers, and computer program product thereof
IPC: G06F7/58
Filed: 2006-07-30
Abstract: A random number generator uses the output of a true random generator to alter the behavior of a pseudo-random number generator. The alteration is performed by a mixing logic that builds a random seed for the pseudo-random number generator and includes a generator of an alteration signal, the generation of which exploits the random instant of arrival of the bits outgoing from the true random generator. The alteration signal is obtained by processing the seed by means of the pseudo-random sequence.
Patent IL-189072-A0 (IL)
Title: Base station synchronization for wireless communication systems
IPC: H04B1/707
Filed: 2008-01-28
Abstract: The present invention is a system and method for time synchronizing a plurality of base stations in a wireless commonication system. The system determines an estimate of a timing accuracy associated with each base station. When a base station's timing accuracy is over a threshold, the system determines if there is a neighboring base station with a better timing accuracy. The base station over the threshold is adjusted in response to an estimated difference between that base station and the neighboring base station.
Patent IL-212140-A0 (IL)
Title: Antibodies against acpl polypeptides
IPC: C12N15/24
Filed: 2011-04-05
Abstract: The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
Patent IL-213880-A0 (IL)
Title: Method for operating a bus system
Filed: 2011-06-30
Abstract: The bus system (1) has a high-ranking unit (11, 13) and a subordinate unit. The system exchanges address and data information via a bus (15). Other fields (44) are provided between fields (42, 43) for the address and data information, for the rapid exchange of messages. A head (41) of a data block covers several synchronization fields (45) and a field (46) for the announcement of a message status. The fields for the address and data information are placed in front, where the data information follows the address information. An independent claim is included for method for operating the bus system.
Patent RO-135337-A0 (RO)
Title: Ito supports modified with reduced graphene oxide functionalized with au nanoparticles, for applications in the optical detection of pharmaceutical compounds
Inventor: BAIBARAC MIHAELA
IPC: G01N33/15
Filed: 2021-07-22
Abstract: The invention relates to supports for glass slips coated with indium and tin oxides ITO with reduced graphene oxide RGO, functionalized with Au nanoparticles, to be used in Raman spectroscopy for optical detection of organic compounds in the pharmaceutical field. According to the invention, the supports are made by coating the surface of the ITO support with the RGO solution in dimethyl formamide by drop casting and functionalizing the RGO-modified ITO support with Au nanoparticles by cyclic voltammetry, and, in the particular case of acetaminophen, the RGO-modified ITO support functionalized with Au nanoparticles exhibits a linear dependence in the concentration range of 2.5...30 mM.
Patent AP-2001002248-A0 (AP)
Title: Method for treating COPD.
Inventor: CHRISTENSEN SIEGFRIED BENJAMIN
IPC: A61K31/40
Filed: 2000-03-01
Abstract: This invention relates to a method for the prophylaxis of or for treating COPD by administering a PDE4 inhibitor which has a defined therapeutic ratio.
Patent MW-8990-A1 (MW)
Title: Polyester bottles
IPC: B29C49/06
Filed: 1990-11-22
Abstract: Bottles can be made, especially by extrusion stretch blow moulding, using a thermoplastic polymer composition comprising a polymer, preferably a polyester, which contains metal particles especially of sb, which intrinsically absorb radiation in the wavelength region 500 nm to 2000 nm, in a quantity such that the reheat time of the polymer is less than the reheat time of the polymer in the absence of that quantity of particles. A method of making such metal containing polymer compositions by reducing a metal compound in situ is also described.
Patent IE-910299-A1 (IE)
Title: Casing system for the laying of electrical supply conductors
IPC: H02G/
Filed: 1991-01-29
Abstract: A casing system for laying electric supply conductors and, if desired, signal conductors along the outer surfaces of walls of buildings comprises elongated casing sections (103) having longitudinal cavities (113, 115) for accommodating at least two supply conductors (117). The system also comprises end sections (101) and corner sections (201, 202), as well as sliding cover sections (102) for interconnecting these and the casing sections (103) to form a continuous casing structure covering any given length of wall without cutting or other adaptation of any of the sections. Distributed over its length each casing section (103) has access modules (X, Y, Z), where access can be established to the supply conductors (117) by means of connectors (145) having forked contact legs (151) that can be pushed through access slots (132) in the front wall (110) of the section into engagement with contact pieces (124) clamped on the conductors (117). In each access module, the contact pieces (124) are held in position behind the access slots (132) by means of a front holder (126) and a rear holder (127), which penetrate into the cavities (113, 115) from the front and rear side of the section (103) and are mutually interlocked. The rear holder (127) is constructed for attachment to a wall of a building and thereby serves to suspend the supply conductors (117) directly from the wall.
Patent IE-910469-A1 (IE)
Title: Stabilized sulfonate, sulfate, phosphonate and phosphate¹derivatives of hirudin
IPC: A61P7/02
Filed: 1991-02-12
Abstract: This invention relates to peptide derivatives which are useful anticoagulant agents.
Patent LU-70163-A1 (LU)
IPC: C07C45/53
Filed: 1974-05-27
Abstract: A process is provided for the preparation of aryl ketones by catalytic decomposition of tertiary hydroperoxides, in particular for the preparation of acetophenone from cumene hydroperoxide, said process comprising effecting the catalytic decomposition of a tertiary hydroperoxide of the formula:   <IMAGE>   in which Ar represents a monovalent aromatic radical, the free valency of which is carried by a carbon atom belonging to an aromatic ring, and R1 and R2, which may be identical or different, each represents a monovalent aliphatic radical or R1 and R2 together form a divalent aliphatic radical, in a reaction medium comprising water, an inorganic or organic derivative of copper and a phenol, and at a temperature of from 50 DEG  C to 150 DEG  C.
Patent LU-82188-A1 (LU)
Inventor: DE MEESTER P
IPC: C25D21/12
Filed: 1980-02-21
Abstract: The process for treating a photographic fixing bath, in order to remove therefrom the silver in metallic form by electrolysis in an electrolysis cell comprising at least one cathode on which the silver is deposited, two anodes and a control electrode placed in the vicinity of the cathode, comprises the step of adjusting the intensity of the electrolysis current by measuring the potential difference between a cathode serving as a working electrode and the control electrode. The apparatus for treating a photographic fixing bath in order to remove therefrom the silver comprises an electrolytic cell containing, as electrodes, at least one cathode and anodes as well as a control electrode made of pure carbon immersed in a stirred electrolytic bath, the voltage of this control electrode being maintained at a constant reference value and the potential on this control electrode serving to control the electrolysis current in operation.
Patent MA-18504-A1 (MA)
Inventor: JOHAN WILLEM HOOGENDONK
IPC: C05G1/00
Filed: 1979-07-02
Abstract: Granular NPK-fertilizers are prepared by granulating a liquid mixture obtained by adding a solid, particulate potassium salt to a liquid ammoniumnitrate containing phase, which either contains ammoniumphosphate or to which this is not added. 
<??>The potassium salt particles have an average size no greater than 55  mu , while less than 1%wt are larger than 150  mu , and are added at a temperature between 5 and 40 DEG C. 
<??>The resulting granules show an excellent storage-stability.
Patent MA-20914-A1 (MA)
Inventor: JYRI JARVENKYLA
IPC: B29C48/13
Filed: 1987-03-18
Abstract: This invention relates to a method and an apparatus for the production of ribbed pipes. The apparatus comprises a core (8, 9, 10) which together with an extrusion sleeve (4) forms a nozzle (11) through which a plastic material is fed into a moulding space (12) defined between a mandrel (9) and chill moulds (1, 2) moveable with respect to the mandrel. Ribbed pipes produced by means of known apparatuses have, for various reasons, an uneven inner face, incomplete ribs or air closures and weak seams in the pipe walls and ribs. These disadvantages can be eliminated by such a dimensioning of the moulding space (12) of the apparatus and the grooves (13) of the chill moulds that the volume of a space defined between a plane (20) extending adjacent to the end face of the extrusion sleeve, a surface (16) of the mandrel, and a plane (17) comprising the envelope surface of the kernel (10) equals to the combined volume of the grooves (13) positioned within the area of the mandrel at each particular moment.
Patent MA-37941-A1 (MA)
Title: Dérivés d'aryléthynyle
Inventor: STADLER HEINZ
IPC: C07D413/04
Filed: 2013-09-23
Abstract: La présente invention concerne des dérivés d'éthynyle de formule (i) dans laquelle • r est phényle, 3 -fluorophényle, 4-fluorophényle ou 2,5-di-fluorophényle, • ou un sel d'addition d'acide pharmaceutiquement acceptable, sous forme d'énantiome pur ayant la configuration absolue telle que représentée dans la formule (i). Il a été découvert de manière inattendue que les composés de formule générale i sont des modulateurs allostériques du récepteur de glutamate métabotropique de sous-type 5 (mglur5) qui sont utiles pour le traitement de la schizophrénie, des troubles cognitifs, du syndrome de l'x fragile ou de l'autisme et qui présentent des propriétés biochimiques, physico-chimiques et pharmacocinétiques avantageuses par rapport aux composés de l'art antérieur.
Patent MA-38686-A1 (MA)
Title: Anticorps anti-acide téichoïque de la paroi cellulaire et conjugués associés
Inventor: VANDLEN RICHARD
IPC: C07K16/12
Filed: 2014-05-30
Abstract: La présente invention concerne des anticorps anti-acide téichoïque de la paroi cellulaire et leurs conjugués antibiotiques, ainsi que leurs méthodes d'utilisation.
Patent MA-38914-A1 (MA)
Title: Methode d'authentification anti-espionnage par dessus l'epaule (shoulder surfing)
Inventor: KAMAL BENZEKKI
IPC: H04K1/00
Filed: 2016-03-17
Abstract: L'invention concerne une manière d'enter un mot de passe pour se prémunir contre l'espionnage par-dessus l'épaule (shoulder surfing). La méthode inventée permet à un utilisateur de s'authentifier en tapant des caractères aléatoires qui contiennent le mot de passe réel. Afin d'extraire le mot de passe réel lors de la saisie sur une interface utilisateur d'une technologie requérant une authentification par mot de passe, nous avons mis en place une fonction qui se base sur une paire de délimiteurs choisis à base d'un ou plusieurs caractères établis au préalable. La fonction exécutée au niveau de l'interface utilisateur permet, d'une part, de détecter les délimiteurs qui identifient le début et la fin du mot du passe inséré dans la chaine de caractères aléatoires, d'autre part, supprimer l'ensemble des caractères aléatoires saisis, y compris les délimiteurs. Après l'extraction du mot de passe, celui-ci est renvoyé au système authentificateur avec l'identifiant associé pour la vérification/identification.
Patent MA-40793-A1 (MA)
Title: Composition acide a base de leonardite et d'acides amines
Inventor: VALIERI GIANLUCA
IPC: C05G3/70
Filed: 2017-08-04
Abstract: La présente invention se réfère à une composition acide qui comprend : léonardite, acides aminés et agents de surface en vue d'une utilisation en tant qu'engrais, biostimulant et/ou nutriment et à un procédé pour obtenir cette composition.
Patent MA-49873-A1 (MA)
Title: Procédé de récupération de métaux à partir de matériaux contenant du cobalt
Inventor: SUETENS THOMAS
IPC: C22B23/02
Filed: 2018-10-22
Abstract: Cette invention concerne un procédé de récupération de métaux à partir d'un matériau métallifère contenant, sous forme oxydée, plus de 1 % de co, un total de co et de ni supérieur à 15 %, et plus de 1 % de mg, comprenant l'étape consistant à : - faire fondre ledit matériau métallifère dans un four à bain conjointement avec des agents scorifiants, ce qui permet de produire une phase d'alliage avec plus de 80 %, de préférence plus de 90 % de co, et moins de 1 % de mg, et une phase de laitier, en appliquant des conditions de fusion réductrice, et en sélectionnant le cao, le sio2 et l'al2o3 en tant qu'agents scorifiants, en des quantités permettant d'obtenir une composition finale de laitier suivant le rapport 0,25 < sio2/ai2o3 < 2,5, 0,5 < sio2/cao < 2,5, et mgo > 10 %; et - séparer la phase d'alliage de la phase de laitier. Ce procédé assure la récupération quantitative de co dans une phase d'alliage avec d'autres métaux tels que le ni, tout en collectant le mg dans un laitier. Du fait qu'il est exempt de mg, l'alliage obtenu peut être affiné de manière économique par des techniques hydrométallurgiques, en particulier pour la préparation de précurseurs destinés à être utilisés en tant que matériau de cathode dans des batteries li-ion.
Patent UY-23868-A1 (UY)
Inventor: MARC HENRI MITAL
IPC: A61G1/048
Filed: 1994-12-09
Abstract: PCT No. PCT/FR93/01231 Sec. 371 Date Jun. 7, 1995 Sec. 102(e) Date Jun. 7, 1995 PCT Filed Dec. 10, 1993 PCT Pub. No. WO94/13240 PCT Pub. Date Jun. 23, 1994A stretcher comprises an upper sheet and a lower sheet selectively joined together to form a plurality of transverse sleeves. In combination, a plurality of slats having a length greater than the transverse dimension of the sleeves are removably retainable within the transverse sleeves. The slats are provided at their end portions located outside said sleeves with handles to permit transporting of the stretcher. Alternatively, the stretcher comprises a sheet having on one of its surfaces strips (16) of hook and loop type elements, in combination with a plurality of slats that are longer than the width of the sheet. The slats have hook and loop type fasteners adapted to cooperate to removably attach the slats to the hook and loop type fastener strips on the sheet. The said slats have handles at their end portions, spaced from the edges of the sheet, to permit transporting of the stretcher.