baber/WOPTO huggingface dataset:
Patent EA-016138-B1 (EA)
Title: Compounds, pharmaceutical compositions and methods for treating heart failure
Inventor: MORGAN BRADLEY P
IPC: A61K31/40
Filed: 2005-06-16
Abstract: A compound of formula A is proposedwhich can be named methyl 4-[(2-flouro-3{[(6-methyl(3-pyridile)amino]carbonylamino}-phenyl)methyl]piperazinecarboxylate or a pharmaceutically acceptable salt thereof comprising a pharmaceutically acceptable excipient, vehicle or adjuvant and a compound of formula A or a pharmaceutically acceptable salt. A method is also proposed for treating cardiac failure in mammals comprising administration a mammal a therapeutically acceptable amount of the compound of formula A or a pharmaceutically acceptable salt or a pharmaceutical composition comprising the compound of formula A or a pharmaceutically acceptable salt. Wherein the heart failure is a congestive heart failure, including a systolic heart failure.
Patent EA-012493-B1 (EA)
Title: Ferrosilide anode grounding assembly of electrochemical protection of underground gas, oil products pipelines and water conduits engineering facilities therefor
Inventor: FILATOV GENNADIJ NIKOLAEVICH
IPC: C23F13/00
Filed: 2008-03-04
Abstract: The invention relates to gas/petrochemical industries, in particular, to protecting pipelines against corrosion. The invention is aimed at eliminating drawbacks of existing ferrosilide anode groundings, provide their reliability, easy mounting and operation, guaranteeing operation life time to 20 years with safety factor 2, reducing construction and materials cost used in a unit for electrochemical protection, reducing two times voltage in the anode grounding – pipeline circuit to 24-48 volts, increasing pipeline protection zone to 8 km, providing full dissolution of ferrosilide alloy and free oxygene discharge in the atmosphere, using a deflector for a borehole ventilation and, reducing activator losses. The assembly of ferrosilide anode grounding of electrochemical protection of gas/oil products pipelines and water conduits engineering facilities comprises chains formed by cylindrical links moulded from ferrosilide alloy lowered into a borehole, a steel core with a cut, the core is inside each the link, a guide metal cone 1.5-2 mm thick welded to the bottom chain link, a beam mounted on a foundation having a hole with an isolating bush through which the upper chain link passes, a stop welded to the upper chain link and positioned on isolating spacers made from asbestos-cement material, a contact device welded to the stop and a cable of D.C. source connected thereto, the second end of which is connected to a cathode protection station, a ventilating borehole deflector attached to the beam mounted on the foundation, wherein the second cable extending from the cathode protection station is connected to a pipeline or other object being protected and an activator is arranged between the chain of cylindrical links and the borehole walls, the activator comprises graphite-containing material (one part) and coke (two parts).
Patent EA-016286-B1 (EA)
Title: Compounds which have activity at mreceptor and their uses in medicine
Inventor: BUDZIK BRIAN
IPC: A61K31/4184
Filed: 2006-09-27
Abstract: Compounds which have activity at M1 receptor and their uses in medicine Compounds of formula (I) and salts and solvates are provided: wherein Ris fluoro, Ris selected from hydrogen, halogen, cyano, Calkyl, Calkyl substituted with one or more fluorine atoms, Calkoxy, and Calkoxy substituted with one or more fluorine atoms; and Ris selected from halogen, cyano, Calkyl, Calkyl substituted with one or more fluorine atoms, Ccycloalkyl, Ccycloalkyl substituted with one or more fluorine atoms, Calkoxy and Calkoxy substituted with one or more fluorine atoms, and Q is hydrogen or Calkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.
Patent EA-016415-B1 (EA)
Title: Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
Inventor: KRASUTSKY ALEXEI PAVLOVICH
IPC: A61K31/4015
Filed: 2007-04-24
Abstract: The present invention discloses novel compounds of Formula Ihaving 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11β-HSD type 1 activity.
Patent EA-018444-B1 (EA)
Title: GENETIC VARIANTS ON Chr 5p12 AND 10q26 AS MARKERS FOR USE IN BREAST CANCER RISK ASSESSMENT, DIAGNOSIS, PROGNOSIS AND TREATMENT
Inventor: STACEY SIMON
IPC: C12Q1/68
Filed: 2008-05-21
Abstract: The invention pertains to certain genetic variants on Chr5p12 and Chr10q26 as susceptibility variants of breast cancer. Methods of disease management, including diagnosing increased and/or decreased susceptibility to breast cancer, methods of predicting response to therapy and methods of predicting prognosis using such variants are described. The invention further relates to kits useful in the methods of the invention.
Patent EA-016533-B1 (EA)
Title: Method for selective-recirculating liquid atomisation and a device for carrying out said method
Inventor: NADMITOV SERGEI VIKTOROVICH
IPC: B01F25/70
Filed: 2008-08-28
Abstract: The invention relates to methods and devices for atomising liquid during production processes using an uniform dispersion mixture, in particular in internal combustion engines requiring a fine fuel-air mixture, in the chemical industry for devices for rinsing gas with liquid which use an uniform coarse-dispersion mixture for reducing the drop entrainment of a rinsing liquid. The inventive method consists in collecting, during the liquid atomisation which is carried out by supplying a liquid jet at an angle to a gas flow, particles from the areas of spray flair which corresponds to the specified particle sizes. The particle atomisation and collecting processes are carried out at one section of a laminar unidirectional gas flow. The collected particles form, when accumulated, a liquid which is returned to re-atomisation. The inventive device comprises a body (1) with an internal channel (2) for producing a laminar unidirectional gas flow, an atomising nozzle (3) which is positioned at an angle to the gas flow direction and is connected to a pipe for supplying a liquid to be atomised (6) and a particles collector (4) which is designed and located in such a way that it is able to collect the particles from the areas of spray flair which corresponds to the specified particle sizes. In the first variant, the collector is coupled to a pipe (5) for returning the liquid to re-atomisation, and in the second variant, the collector is coupled to an additional spraying nozzle (7) made in the internal channel of the body.
Patent EA-018041-B1 (EA)
Title: Pipeline heat insulation
Inventor: PAVLYUK EVGENY SERGEEVICH
IPC: F16L59/06
Filed: 2010-07-22
Abstract: The invention relates to construction and can be used for heat insulation of metal pipes for use in heating mains. The present insulation is aimed at providing the required stability of an outer protection of heating insulation elements against unfavorable factors: humidity, temperature drops and ultraviolet radiation, while preserving all functional heat-insulating properties as well as simplicity of structure. Moreover, another task is aimed at simple assembling/disassembling of insulation, if necessity arises. The assigned task is characterized in that an inner pipe layer is made of a heat resistant material and an outer layer of a moisture resistant material, wherein the thickness of the heat resistant material constitutes 15-75% of the total thickness of the heat insulation element. There are some differences from the prototype. The use of the invention provides higher durability of a pipeline heat insulation against an outer weather conditions, thus preserving strength and proper heat insulation properties of a pipeline. It results in increasing pipeline life time, while preserving all functional heat-insulating properties.
Patent EA-018043-B1 (EA)
Title: A method of stretch-blow-moulding a beverage container
Inventor: VESBORG STEEN
IPC: B29B11/08
Filed: 2009-01-06
Abstract: A method of stretch-blow-moulding a beverage container for containing a carbonized beverage which method comprises providing a preform having a neck part and a body part. The preform includes an inner layer of a first polymeric composition, an outer layer of a second polymeric composition, and an intermediate layer of a third polymeric composition. The third polymeric composition has adhesive surface properties relative to the first and second polymeric compositions, and the adhesive surface properties are permanently degraded by exposure to irradiation of a certain wavelength or certain wavelengths and intensity. The method further comprises mounting the preform onto a stretch-blow-moulding device and blow moulding the preform into the beverage container by irradiating the body part with radiation at least including the certain wavelength or certain wavelengths and intensity while protecting the neck part from any substantial radiation.
Patent EA-019588-B1 (EA)
Title: Sandwich panel and method for producing such a panel
Inventor: PEETERS JOHANNES HENDRICUS ALPHONSUS
IPC: B29C70/86
Filed: 2009-07-17
Abstract: A panel possessing mutually averted panel surfaces and a periphery which delimits the panel surfaces is made up of a series of elongated core elements positioned parallel to one another, as well as material strips which are affixed to the core elements and which each extend between respectively two neighboring core elements and along both panel surfaces. Such a panel can expediently be constructed by placing a number of core elements and strips of flexible material side by side, or by stacking these one upon the other.
Patent EA-022567-B1 (EA)
Title: Naked collation package
Inventor: FRIZELL BARRY
IPC: B65D85/10
Filed: 2009-12-14
Abstract: The present invention concerns variants of a naked collation package (1, 21, 31, 41, 51) comprising a plurality of individual units (2, 32, 52) laid end-to-end or side-by-side to form a unit row. The naked package of the invention comprises at least one interface (3, 33, 63) between a neighbouring pair of individual units in the unit row; the unit row being overwrapped with a sheet of polymeric film, the sheet being provided along its length, or part or parts of it, with one or at least two lines of weakness positioned in substantial register with the interface, said lines of weakness being oscillating lines of weakness. The invention also concerns processes for the production of said naked collation package.
Patent EA-020767-B1 (EA)
Title: Novel forms of bendamustine free base
Inventor: COURVOISIER LAURENT D
IPC: C07D235/16
Filed: 2010-01-14
Abstract: Novel polymorphic forms of bendamustine free base are described in the invention, including amorphous bendamustine free base, six anhydrous crystalline forms, four hydrate forms, and five solvate forms, methods of their preparation and use also being described.
Patent EA-024884-B1 (EA)
Title: Method for producing cooked sausages
Inventor: GORDYSHEVSKY SEMEN MIKHAILOVICH
IPC: A23L13/60
Filed: 2013-01-09
Abstract: The invention relates to meat industry. A method provides for raw meat preparation, grinding and preliminary salting all raw meat, namely beef and semi-fat pork, by mixing with salt and the food additive Natur Mix and a part of water, soaking in brine, preparation of minced meat by means of cutting, with adding of fat, dry milk, egg or egg mixture and water and/or ice, filling casings with minced meat, tying baloneys and thermal treatment at the following ratio of components, wt.%: dry milk whey - 2.0-2.4, haemoglobin - 0.07-0.2, fermented rice - 0.07-0.2, spices - 0.2-0.5, salt - 1.13-1.8, minced meat-beef - 5-15, semifat pork - 40-75, fat - 5-15, egg or egg mixture - 1-2, dry milk - 2-3, water and/or ice - the rest. To produce cooked sausages with reduced content of fat, it is proposed to use poultry meat and chicken fat as minced meat ingredients together with beef at the following ratio of components, wt.%: dry milk whey - 2.0-2.4, haemoglobin - 0.07-0.2, fermented rice - 0.07-0.2, spices - 0.2-0.5, salt - 1.13-1.8, minced meat-beef - 5-15, poultry meat - 40-75, chicken fat - 5-10, egg or egg mixture - 1-2, dry milk - 2-3, water and/or ice - the rest.
Patent EA-027839-B1 (EA)
Title: V-type ditching apparatus
Inventor: PENNER JEFFREY RYAN
IPC: E02F5/02
Filed: 2011-12-08
Abstract: A ditching apparatus features front blade sections fixed to the frame in a V-configuration, and a pull tongue extending over the blade apex to a pivotal connection near a rear end of the frame. An actuation mechanism effects relative pivoting between the frame and the pull tongue to adjust an angle between the front blade and the trailer tongue to control a ground-penetration depth of the blade apex. Two rear blade sections on opposing sides of the frame are movable between deployed positions extending rearwardly and laterally outward from the front blade sections, and stowed positions elevated out of the deployed positions. The blade angle and width are thus controllable to achieve a desired depth and width of ditch. A nose cap at the blade apex provides an improved action, providing internally braced blade structures with durability and smooth movement relative to the ground.
Patent EA-026614-B1 (EA)
Title: Sealed threaded joint for casing pipes
Inventor: REKIN SERGEY ALEXANDROVICH
IPC: F16L15/06
Filed: 2014-12-29
Abstract: The invention is related to the oil and gas extraction industry. A joint comprises male and female elements with trapezoidal buttress threads at their ends, the threads having 1:16 taper, a slope angle between the thread profile lead-in flank and the thread axis normal line of 10-30°, and a slope angle of the bearing flank of 0 to -10°. The outer sealing unit is formed by radial sealing surfaces extending at an angle of 7-12° to the thread axial line, and bearing end surfaces made at an angle of 5-17° to the thread axis normal line. The inner sealing unit is formed by radial sealing surfaces extending at an angle of 1.5-4.0° to the thread axial line. In a length equal to 20-40% of the total thread length on the male end, beginning from the first thread, machining of the threads is performed for decreasing their height to 50% of the total thread profile height. On the female element, in the thread run-out area, a circumferential groove is made, the transition from the groove surface to the radial sealing surface being spherical. Provided are gas tightness of the joint under action of multidirectional loads, better screwing properties and higher wear resistance of the joint.
Patent EA-028520-B1 (EA)
Title: Etanercept formulations stabilized with meglumine
Inventor: MANNING MARK
IPC: A61K39/395
Filed: 2012-10-18
Abstract: The present invention is an aqueous stabilized formulation of etanercept, free of arginine, comprising 25-75 mg/ml etanercept; 1-30 mM of sodium phosphate; 0.5-10 wt.% meglumine, wherein the composition has a pH of 6.0-6.6. The stabilized formulation of etanercept by the present invention is suitable for long-term storage of etanercept.
Patent EA-028202-B1 (EA)
Title: Anti-lrp5 antibodies and methods of use thereof
Inventor: YE WEILAN
IPC: G01N33/50
Filed: 2013-01-18
Abstract: The invention provides anti-LRP5 antibodies and methods of making and using the same.
Patent EA-026803-B1 (EA)
Title: Tipping element for a smoking article
Inventor: MCLAUGHLIN DAVID
IPC: A24D3/04
Filed: 2013-02-21
Abstract: A tipping element for a smoking article. The smoking article comprises a tobacco rod and a filter secured to the tobacco rod by the tipping element. The smoking article comprises a user-activated component for altering smoke passing through the filter and said tipping element comprises an indicator component for cooperating with the user-activated component to indicate when the user has activated the user-activated component.
Patent EA-032883-B1 (EA)
Title: Method for producing a sheet of selectively etched glass
Inventor: SINAPI FABRICE
IPC: C03C15/00
Filed: 2013-06-07
Abstract: The present invention concerns a method of selective chemical etching of a glass sheet, using a mask, making it possible to limit the etching of the glass under the edges of the mask, and to obtain a glass sheet selectively etched with patterns which can be very small and of which the contours exhibit a high level of sharpness. In particular, the invention concerns a method for producing a selectively etched glass sheet, comprising the following successive steps: a) a masking step (1) which comprises selectively depositing on one of the faces of the sheet an UV-crosslinkable liquid organic composition, comprising at least one photoinitiator and a mixture of monomers and/or oligomers, using at least one ink-jet head, and cross-linking said liquid composition by exposure to ultraviolet radiation, wherein the crosslinking of the liquid composition is simultaneous with the deposition thereof; b) an etching step (2) during which the areas of said face of the sheet which are not covered by the crosslinked composition are chemically etched; and c) a finishing step (3) which comprises removing said crosslinked composition.
Patent EA-031990-B1 (EA)
Inventor: CORRIA OSORIO ANGEL DE JESUS
IPC: A61K38/18
Filed: 2013-10-30
Abstract: Изобретение относится к области биотехнологии и, в частности, к мутированным полипептидам молекулы TGFβ, первичная последовательность которой обладает высокой гомологией с последовательностью TGFβ человека. Указанные мутеины утрачивают способность взаимодействовать с ALK5, но сохраняют способность взаимодействовать с другими рецепторами, входящими в комплекс рецепторов (TβRII и TβRIII). Мутеины по настоящему изобретению обладают способностью оказывать антагонистическое воздействие на передачу сигналов всех природных вариантов лигандов TGFβ, зависящую от рекрутинга ALK5, в комплекс рецепторов и характеризуются значительным иммуномодулирующим действием. Изобретение также относится к фармацевтическим композициям, включающим в качестве активного компонента полипептиды или гибридные белки по настоящему изобретению, и к применению указанных композиций для оказания модулирующего воздействия на иммунную систему в случае таких заболеваний, как рак, заболевания, сопровождаемые фиброзом, и хронические инфекционные заболевания.
Patent EA-033244-B1 (EA)
Title: Device to diagnose pregnancy and infertility in cows
Inventor: DZHAKUPOV ISATAJ TUSUPOVICH
IPC: A61D99/00
Filed: 2016-07-01
Abstract: The device relates to veterinary obstetrics, gynecology and reproduction biotechnology, including detection of pregnancy and infertility in animals. The technical purpose of the project is to develop a device to detect pregnancy and infertility in cows. The device locates the uterus within the pelvic cavity at early stages of pregnancy relative to the external genital organs, and allows removing mucus from the vaginal part of the uterine neck to determine its physical and chemical properties. The device for diagnosing pregnancy and infertility in cows contains a triple-colored graded cylindrical casing that has a graduation scale to measure the position of the uterus in the pelvic cavity relative to external genital organs. The end of the casing has a rubber receptacle used to sample mucus. The front side of the device has a handle with an opening for a rope used to fix the device. The handle at the top protrudes by 1 – 1.5 cm to prevent the hands from contact with mucus when working with infertile animals. At the bottom of the handle there is a bend for more convenient removal of the device. The presented device to diagnose pregnancy and infertility enables easier sampling and analysis, gives an insight of changes and displacements of the anatomical and topographic position of the genitals during various stages of pregnancy, it helps to diagnose infertility, is easy to use and can be used by both veterinarians and farmers to diagnose pregnancy and infertility in cows.
Patent EA-031281-B1 (EA)
Title: Chain comprising polymeric links and a spacer
Inventor: WIENKE DIETRICH
IPC: F16G13/12
Filed: 2014-12-09
Abstract: The present invention relates to a chain comprising a plurality of chain links comprising a polymeric fiber, wherein said chain comprises at least one spacer having a thickness Δ at the contact location through which loads are directly transmitted between said chain links and a ratio Δ/τ=f, with τ being the thickness of any of the chain links at the contact location through which loads are directly transmitted between said chain links and f being in a range between 0.10 and 2.50. The invention further relates to the use of said chain for storing, securing, lashing and tying down for handling and transporting cargo, in lifting and hoisting, logging, hauling and rigging, propulsion and driving, mooring, cargo-hold of an aircraft or naval ship.
Patent EA-032098-B1 (EA)
Title: Skin care composition
Inventor: BATCHELOR STEPHEN NORMAN
IPC: A61K8/49
Filed: 2015-03-10
Abstract: A skin care composition is described comprising a water-soluble dye polymer comprising a polymer backbone having a negatively charged reactive dye substituent covalently bound thereto; and a cosmetically acceptable carrier. The dye polymer is present in amount of 0.00001 to 0.1% in terms of the reactive dye substituent by weight of the skin care composition. The polymer backbone is derived from polyethyleneimine, polysaccharide, polyurethane or a polymer having the INCI designation Polyquaternium. The described composition is useful for providing a cosmetic benefit such as skin lightening, evening skin tone, providing or enhancing natural skin tone, providing or enhancing pinkish appearance and masking blemishes.
Patent EA-032215-B1 (EA)
Title: Urea composition and method for producing same
Inventor: KRAWCZYK THOMAS
IPC: C05G5/12
Filed: 2015-06-17
Abstract: The invention relates to a particulate urea-containing composition, to a method and a device for producing same, to the use thereof as fertilizer, as technical urea, or as a feed additive, and to the use of an additive for producing a particulate urea-containing composition. The particulate composition contains (i) urea and an additive comprising one or both of the components (ii) and (iii): wherein (ii) is a combination of at least one amino group-containing polymer or oligomer and at least one functionalized polyvinyl compound; (iii) is at least one aliphatic C-C-dialdehyde; wherein the weight proportion of the component (i) is >60 wt.% and the weight proportion of the sum of the components (ii) and (iii) in the composition is <1 wt.%. The additive can also comprise a component (iv): wherein (iv) is at least one compound selected from the group of aliphatic dicarboxylic acids, the salts and anhydrides thereof; aliphatic tricarboxylic acids, the salts and anhydrides thereof; aromatic dicarboxylic acids, the salts and anhydrides thereof; and aldehyde acids, the salts and anhydrides thereof, wherein the weight proportion of the component (i) is >60 wt.% and the weight proportion of the sum of the components (ii), (iii), and (iv) in the composition is <1 wt.%.
Patent EA-034983-B1 (EA)
Title: Composition comprising vancomycin and orlistat
Inventor: FONTAINE VERONIQUE
IPC: C12Q1/18
Filed: 2015-12-22
Abstract: The present invention relates to novel combinations of substances and novel pharmaceutical compositions for treating mycobacterial infections, and medical uses of those combinations and compositions. The present invention further concerns a method for screening new compounds useful for treating mycobacterial infections and multidrug resistant (MDR) and extremely resistant (XDR) mycobacterial strains.