Patent SG-11201908820V-A (SG)
Title: Novel heterocyclic derivatives useful as shp2 inhibitors
Inventor: MA CUNBO
IPC: C07D241/18
Filed: 2018-03-23
Abstract: International Patent Classification: CO7D 241/18 (2006.01) CO7D 498/10 (2006.01) CO7D 241/20 (2006.01) CO7D 471/10 (2006.01) CO7D 401/14 (2006.01) A61K 31/497 (2006.01) C07D 401/04 (2006.01) A61P 35/00 (2006.01) CO7D 491/107 (2006.01) A61P 35/02 (2006.01) (21) International Application Number: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 September 2018 (27.09.2018) WIPO I PCT ~~ll~~~~~~~~ 011101010VIIIOH olo olomiomim mourn° ow (10) International Publication Number WO 2018/172984 Al PCT/IB2018/051973 (22) International Filing Date: 23 March 2018 (23.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/IB2017/051690 23 March 2017 (23.03.2017) IB (71) Applicants: JACOBIO PHARMACEUTICALS CO., LTD. [CN/CN]; Unit 2, Building 5, BYBP, No.88 Kechuang Street 6th, Business Development Area, Dax- ing, Beijing 101111 (CN). JACOBIO-ALPHA PHAR- MACEUTICALS CO., LTD. [CN/CN]; Unit 2, Building 5, BYBP, No.88 Kechuang Street 6th, Business Develop- ment Area, Daxing, Beijing 101111 (CN). (72) Inventors: MA, Cunbo; Unit 2, Building 5, BYBP, No.88 Kechuang Street 6th, Business Development Area, Daxing, Beijing 101111 (CN). GAO, Panliang; Unit 2, Building 5, BYBP, No.88 Kechuang Street 6th, Business Development Area, Daxing, Beijing 101111 (CN). HU, Shaojing; Unit 2, Building 5, BYBP, No.88 Kechuang Street 6th, Business Development Area, Daxing, Beijing 101111 (CN). XU, Zi- long; Unit 2, Building 5, BYBP, No.88 Kechuang Street 6th, Business Development Area, Daxing, Beijing 101111 (CN). HAN, Huifeng; Unit 2, Building 5, BYBP, No.88 Kechuang Street 6th, Business Development Area, Daxing, Beijing 101111 (CN). WU, Xinping; Unit 2, Building 5, BYBP, No.88 Kechuang Street 6th, Business Development Area, Daxing, Beijing 101111 (CN). KANG, Di; Unit 2, Building 5, BYBP, No.88 Kechuang Street 6th, Business Development Area, Daxing, Beijing 101111 (CN). LONG, Wei; Unit 2, Building 5, BYBP, No.88 Kechuang Street 6th, Business Development Area, Daxing, Beijing 101111 (CN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE (54) Title: NOVEL HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS cc N Y~ - Y l Formula I 1-1 (57) : This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula N I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated 0 disorder.