baber/WOPTO huggingface dataset:
Patent CA-2449042-A1 (CA)
Title: In silico screening for phenotype-associated expressed sequences
Inventor: KOZLOV ANDREY V
IPC: G16B40/20
Filed: 2002-05-30
Abstract: The present invention provides methods for determining whether a nucleic acid sequence is a marker for a phenotype or cell type of interest which comprises providing a database of expressed sequence tag sequences (EST's) from the species; placing said EST's in groups termed clusters based on homology of EST's within each cluster; determining for each cluster the total number of EST"s within said cluster; ordering said clusters sequentially based on the number of EST's in each cluster; dividing said ordered clusters into subranges based on the number of EST's per cluster; determining for each cluster subrange obtained from step (e) the number EST's within said cluster which are expressed in said predetermined cell type of interest; calculating according to a normal distribution the number of clusters in each subrange expected to contain a predetermined threshold percentage of EST's expressed in said cell type of interest, wherein said threshold percentage is a percentage from about 10% to about 100%; determining the number of clusters in each subrange observed to contain said predetermined threshold percentage of EST's expressed in said predetermined cell type; and identifying subranges having an observed number of clusters that meet said predetermined threshold percentage greater than the number of clusters expected to meet said predetermined threshold percentage for the subrange according to normal distribution; wherein if the percentage of EST's expressed in said cell type of interest in a cluster identified is equal to or greater than said predetermined threshold percentage, the cluster contains a nucleic acid that is a marker for the cell type of interest.
Patent CA-2450355-A1 (CA)
Inventor: SHIPMAN ROBERT ANDREW
IPC: H04L45/42
Filed: 2002-05-30
Abstract: A method of operating a wireless network with a base station and a plurality of outstations comprising: i. transmitting a broadcast signal from the base station; ii. monitoring operational status of outstations in the wireless network from an outstation; iii. collecting data representative of outstation status; iv. in response to reception of the broadcast signal, transmitting an acknowledgement signal from the outstation; wherein an outstation relaying an acknowledgement signal appends to the acknowledgement signal data representative of the collected data, and wherein the base station, upon receipt of an acknowledgement signal, retrieves the collected data and varies the rate at which signals are broadcast from the base station in accordance with the collected data.
Patent CA-2451347-A1 (CA)
Title: Glycopeptides, preparation et utilisation de ces glycopeptides pour le diagnostic ou le traitement de la sclerose en plaques
Inventor: PAPINI ANNA MARIA
IPC: C07K14/705
Filed: 2002-06-19
Abstract: L'invention concerne des glycopeptides qui permettent d'identifier les anticorps de la sclérose en plaques et qui, par conséquent, conviennent comme outils diagnostiques pour le traitement de cette maladie.
Patent CA-2453214-A1 (CA)
Inventor: SULZLE DETLEV
IPC: A61K51/00
Filed: 2002-07-18
Abstract: L'invention concerne des conjugués de complexes métalliques macrocycliques contenant des biomolécules et leur utilisation. Ces conjugués s'utilisent comme agents de contraste dans le radiodiagnostic et le diagnostic par résonance magnétique ainsi que comme agents destinés à la radiothérapie. Une liaison spécifique des macrocycles permet d'obtenir une relaxivité élevée et permet un réglage fin de cette relaxivité.
Patent CA-2455966-A1 (CA)
Inventor: FLOHR STEFANIE
IPC: C07D233/70
Filed: 2002-07-20
Abstract: The present invention relates to novel imidazolidine derivatives of the formula (I), in which B, E, W, Y, R, R2, R3, R30, e and h have the meanings given in the claims. The compounds of the formula (I) are valuable pharmaceutical active compounds which are suitable, for example, for treating inflammatory disease, for example rheumatoid arthritis, or allergic diseases.  The compounds of the formula (I) are inhibitors of the adhesion and migration of leukocytes and/or antagonists of the adhesion receptor VLA-4, which belongs to the integrin group. They are generally suitable for treating diseases which are caused by, or associated with, an undesirable degree of leukocyte adhesion and/or leukocyte migration or in which cell-cell or cell-matrix interactions, which are based on the interactions of VLA-4 receptors with their ligands, play a role. The invention furthermore relates to processes for preparing the compounds of the formula (I), to their use and topharmaceutical preparations which comprise compounds of the formula (I).
Patent CA-2461275-A1 (CA)
Title: Compositions containing sucralose
Inventor: SZYMCZAK CHRISTOPHER E
IPC: A61K47/36
Filed: 2004-03-17
Abstract: Coolant coating compositions for substrates, such as those comprised of pharmaceutical active agents, comprising a coating agent, a heat-stable high-intensity sweetener such as sucralose, and a non-volatile cooling agent.
Patent CA-2463389-A1 (CA)
Inventor: LIEBHART DANA
IPC: B29C35/16
Filed: 2004-04-06
Abstract: A machine for the manufacture of inflated plastic dunnage and other fluid filled units is disclosed. In a disclosed and pictured dunnage embodiment, the machine includes a hollow shaft rotatably mounted on a frame. In the preferred embodiment the shaft is solid . With either embodiment a drive is operably connected to the shaft for causing the shaft to rotate about its axis and a drum mounted on the shaft to rotate with the shaft. The drum is in the form of a pair of closely spaced discs having perimetral, cylindrically contoured sealing surfaces for support and, in cooperation with driven metal belts, transport of a web being forms into dunnage units. Sets of heating and.cooling shoes having spaced arcuate surfaces are complementally positioned adjacent the drum surfaces with the cooling shoes downstream from the heating shoes i n the direction of dunnage formation rotation. A nozzle is mounted generally tangentially of th e drum at a location midway between the discs. Each of the cooling shots includes an air expansio n chamber communicating through a shoe inlet when in use with a supply of air under pressure. In the hollow shaft embodiment one cooling shoe chamber has an outlet in communication with the nozzle via the shaft.
Patent CA-2466126-A1 (CA)
Title: Multi-layer golf ball
Inventor: KELLER VIKTOR
IPC: A63B37/02
Filed: 2002-11-05
Abstract: Disclosed herein is a multi-layer golf ball having a soft outer cover (16).  The golf ball has an inner cover layer (14) with a Shore D hardness of 60 or more, and an outer cover (16) with a Shore D hardness of 55 or less. In a preferred form of the invention, the outer cover comprises one or more polyurethane materials. The golf ball of the invention has exceceptionally soft feel and high spin rates on short shots of 80 yards or less while maintaining good distance and average spin on full shots.
Patent CA-2466367-A1 (CA)
Title: Body-conforming bath cushion
Inventor: CHEVRIER EVELYNE
IPC: A47G9/00
Filed: 2004-05-11
Abstract: A novel body bath cushion defined by a body conforming substance, a sectioned waterproof outer layer and a removable, washable cover. The body conforming substance permits the cushion to take the shape of the user's body. Back pain resulting from hard surfaces and uncomfortable slants in the bathtub is avoided using this body cushion. The added feature of sections within the waterproof layer assures that every body part receives adequate support. An additional advantage of this cushion is that within the waterproof layer, a series of masses dispersed throughout permits the cushion to deposit and immobilize itself at the bottom of the bathtub. The cover is a textile that adds comfort to the waterproof outer layer and is designed to be removable and washable in order to maintain proper hygiene conditions. Also the cover is equipped with traction patches to prevent slipping when applying pressure such as getting into and out of the bathtub.
Patent CA-2466724-A1 (CA)
Title: Benzamide and heteroarylamide as p2x7 receptor antagonists
Inventor: DUPLANTIER ALLEN JACOB
IPC: C07D211/76
Filed: 2002-11-04
Abstract: The present invention relates to novel to P2X7 inhibitors of formula (I) and to processes for their preparation, intermediates useful in their preparation, pharmaceuti-cal compositions containing them, and their use in therapy. The active compounds of the present invention are potent inhibitors of P2X7 and as such are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders.
Patent CA-2469144-A1 (CA)
Title: Method and apparatus for determining oriented density measurements including stand-off corrections
Inventor: KURKOSKI PHILIP L
IPC: G01V5/12
Filed: 2002-12-04
Abstract: A logging-while-drilling sensor includes a gamma ray source (114) and at least two Nal detectors (116, 118) spaced apart from the source for determining measurements indicative of the formation density. A magnetometer on the drill collar measures the relative azimuth of the Nal detectors. An acoustic caliper is used for making standoff measurements of the Nal detectors. Measurements made by the detectors are partitioned into spatial bins defined by standoff and azimuth. Within each azimuthal sector, the density measurements are compensated for standoff to provide a single density measurement for the sector. The azimuthal sectors are combined in such a way as to provide a compensated azimuthal geosteering density. The method of the invention may also be used with neutron porosity logging devices.
Patent CA-2469230-A1 (CA)
Title: Anticorps inhibiteurs de gdf-8 et utilisations associees
Inventor: WHITTEMORE LISA-ANNE
IPC: C07K14/475
Filed: 2002-09-26
Abstract: L'invention concerne des nouveaux anticorps contre la croissance et la différentiation du facteur-8 (GDF-8), notamment des fragments d'anticorps, inhibant l'activité de GDF-8 in vitro etin vivo.. L'invention concerne également des procédés de diagnostic, de prévention et de traitement de troubles dégénératifs des métabolismes musculaire, osseux et de l'insuline.
Patent CA-2469356-A1 (CA)
Inventor: HOLLANDER GEORG ANDREAS
IPC: A61K38/16
Filed: 2002-12-03
Abstract: An isolated Shoca polypeptide comprising: (i) the amino acid sequence of SEQ  ID NO: 2 or SEQ ID NO: 4; or (ii) a variant thereof which is capable of interacting with a polypeptide of the wnt signalling pathway; or (iii) a fragment of (i) or (ii) which is capable of interacting with a polypeptide of the wnt signalling pathway, a polypeptide encoding said polypeptide, a method for identifying a modulator of the wnt signalling pathway utilising said polypeptide or polynucleotide and methods of diagnosing and treating cancer.
Patent CA-2470499-A1 (CA)
Title: Surgical patches with a biological active agent
Inventor: SIGNORE PIERRE E
IPC: A61L33/04
Filed: 2002-12-30
Abstract: Surgical patches are described which release an anti-inflammatory agent, an anti-platelet agent, an anticoagulant, a fibrinolytic agent, a cell-cycle inhibitor, and/or an anti-proliferative agent.
Patent CA-2471766-A1 (CA)
Title: Compositions for improving lipid metabolism
Inventor: ANDO KUNIO
IPC: A61P3/04
Filed: 2002-12-27
Abstract: It is intended to provide medicinal compositions which contain as the active ingredient at least one member selected from the group consisting of lactoferrin proteins including lactoferrin and conalbumin and enzymatically digested products of lactoferrin proteins including lactoferricin and peptid es of conalbumin corresponding to lactoferricin. These compositions are usable as lipid metabolism improving agents. Moreover, they are useful in treating lifestyle-related diseases such as hypercholesterolemia, hypertriglycedemia, low-density lipoprotein hypercholesterolemia, high-density lipoprotein hypocholesterolemia, obesity, fat liver, cholesterol cholelithiasis, severe obesity, hyperlipemia, hypertension, type II diabetes and so on. These composition can elevate basal metabolic rate.
Patent CA-2474674-A1 (CA)
Title: Solid preparation containing single crystal form
Inventor: MOCHIZUKI HIROKO
IPC: A61K47/04
Filed: 2003-03-28
Abstract: A solid preparation comprising 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5- thiazolecarboxylic acid in a single crystal form, an excipient, and a disintegrator; and a process for producing the solid preparation.
Patent CA-2475355-A1 (CA)
Inventor: WHYLEY CHRISTOPHER JOHN MARTIN
IPC: G06F9/44
Filed: 2003-02-06
Abstract: The present invention relates to a method for effecting the closure of an application window in response to an event associated with its parent window.  The method comprises polling an indicator associated with the parent application window and in the absence of said indicator accessing a system provided function causing the closure of the application window.
Patent CA-2476499-A1 (CA)
Title: Side-looking nmr probe for oil well logging
Inventor: BEARD DAVID
IPC: G01R33/44
Filed: 2002-02-15
Abstract: A side-looking NMR tool having a main magnet (217), a second magnet (218) an d a transceiver antenna (219). Magnets (217,218) are magnetized in a direction transverse to the longitudinal axis of the magnets. The magnet arrangement produces an arcuate working region (211).
Patent CA-2476659-A1 (CA)
Title: Device for connection between a receptacle and a container and ready-t0 use assembly comprising same
Inventor: ANEAS ANTOINE
IPC: B65D51/18
Filed: 2003-02-19
Abstract: The invention concerns a connection device comprising a base (10) adapted to be mounted on a receptacle (2) and forming a sliding sleeve (15) for a piston (16) which moves or forms a hollow needle (16), an annular skirt (20) for locking the base plate (10) in snap-on configuration on the neck (4) and a cap (30), designed to isolate the plate (10) and/or the piston (16) from ambient air. The cap (30) is provided with at least one protuberance (33) designed to be engaged in the internal volume (V) of said skirt (20), said protuberance (33) extending radially relative to a central axis (X-X') of the cap (30) over a distance (R¿33?) greater than the minimum distance (R¿23?) between said central axis (X-X') and an edge (23) of the opening (O') providing access to the internal volume (V) of said skirt. The protuberance remains integral with the rest (31a) of the cap when the latter is removed from the device. Once the cap (30) is removed from the skirt (20), the protuberance counters its reinsertion into the internal volume (V) of the skirt.
Patent CA-2480142-A1 (CA)
Title: A frame for mounting to a premounted mirror
Inventor: HUNTTING LISA
IPC: A47G1/06
Filed: 2004-09-02
Abstract: A frame is mounted to a front surface of a previously mounted mirror so that recesses in the back side of the frame receive protruding portions of fasteners which attach the frame to a supporting structure. Guide structures are temporarily mounted to the front surface of the mirror to facilitate the mounting of the frame to the mirror. The guide structures are used to suspend the frame in a position forward of the mirror. Then, while the frame is suspended by the guide structures, the frame is pushed toward the mirror so that the frame slides along the guide structures. As a result, adhesive strips, which are mounted to the back of the frame, engage the front surface of the mirror and become adhered thereto, so that the frame is mounted to the front surface of the mirror by the adhesive strips.
Patent CA-2480266-A1 (CA)
Title: Utilisation d'un antagoniste de l'alpha2-adrenorecepteur pour traiter des maladies du snc
Inventor: SIRVIOE JOUNI
IPC: A61K31/496
Filed: 2003-04-03
Abstract: L'invention concerne un procédé pour traiter les symptômes des troubles et états liés au manque de filtrage sélectif ("gating") sensori-moteur avec un antagoniste d'alfa2-adrénorécepteur ou un ester pharmaceutiquement acceptable ou son sel, sélectif vis-à-vis du sous-type alpha2C-adrénocepteur.
Patent CA-2481083-A1 (CA)
Title: Node b and rnc actions during a serving hsdpa cell change
Inventor: TERRY STEPHEN E
IPC: H04L12/56
Filed: 2003-04-04
Abstract: A wireless system and method which suspends data transmission to a node (14) after recognizing a need for a cell change (12), uses scheduling with priority and latency factors (18), and applies modulation and coding based upon a mobile~s feedback (20).
Patent CA-2481739-A1 (CA)
Title: Sustained release of guaifenesin combination drugs
Inventor: BLUME RALPH W
IPC: A61K47/38
Filed: 2003-04-15
Abstract: The invention relates to a novel pharmaceutical modified release formulation of guaifenesin and optionally a second drug which is preferably selected fro m dextromethorphan and pseudoephedrine. The formulation may comprise a hydrophilic polymer, preferably a hydroxypropyl methylcellulose, and a water~insoluble polymer, preferably an acrylic resin, in a ratio range of about one-to-one (1:1) to about nine-to-one (9:1), more preferably a range o f about three-to-two (3:2) to about six-to-one (6:1), and most preferably in a range of about two-to-one (2:1) to about four-to-one (4:1) by weight. This formulation capable of providing therapeutically effective bioavailability o f guaifenesin for at least twelve hours after dosing in a human subject. The invention also relates to a modified release product which has two portions: a first portion having an immediate release formulation of guaifenesin and a second portion having a sustained release formulation of guaifenesin, wherei n one or both portions further comprises dextromethorphan. The modified releas e product has a maximum guaifenesin serum concentration equivalent to that of an immediate release guaifenesin tablet, and is capable of providing therapeutically effective bioavailability of guaifenesin for at least twelve hours after dosing in a human subject.
Patent CA-2485174-A1 (CA)
Inventor: NULL WILLIAM B
IPC: A61B17/70
Filed: 2003-05-01
Abstract: L'invention concerne un dispositif de fixation s'utilisant avec des procédures ALIF qui comprend quelques plaques espacées munies de pointes intégrales sur les surfaces frontales de celles-ci en vue de les mettre sous presse dans des apophyses épineuses de vertébrés adjacents. Une des plaques comporte un socle sphérique qui capte une extrémité de tête sphérique d'une colonne dont l'autre extrémité passe à travers une ouverture de l'autre plaque. Le montage du socle est réalisé de manière à permettre à la colonne de pivoter avec au moins deux degrés de liberté de façon limitée, de manière à permettre le logement de différentes épaisseurs et orientations d'apophyses épineuses dans l'angulation entre les deux plaques sur des vertébrés adjacents. La réception de la colonne dans la seconde plaque permet l'ajustage de l'espacement entre les plaques permettant de loger une installation efficace de l'ensemble sur les apophyses épineuses au moyen d'un instrument de compression, et une maintenance fiable et permanente de cet espacement après retrait de l'instrument de compression. La configuration transversale de la colonne et une ouverture de réception de la plaque inhibent la rotation de la plaque par rapport à la colonne autour de l'axe de colonne, et une vis de fixation placée dans la plaque ouverte met en prise une plate-forme sur la colonne fixant l'espace entre les plaques tel qu'il a été ajusté.
Patent CA-2485306-A1 (CA)
Title: Synthesis of cis-diols from aryl silanes
Inventor: WHITED GREGORY M
IPC: C12N1/21
Filed: 2003-06-03
Abstract: The present invention is related to cis-diols and biological methods of producing cis-diols. The present invention further relates to processes for subsequently converting such silane cis-diols to the more stable acetonide derivatives, as well as a process for converting silane cis-diols to the corresponding catechols and the compounds produced thereby. The present invention also provides chemical methods for the conversion of said silane cis~-diols and acetonide compounds to epoxy, saturated and otherwise modified derivatives. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that is will not be used to interpret or limit the scope or meaning of the claims.
Patent CA-2485582-A1 (CA)
Title: A construction for an overhang in a pit of a milking parlour
Inventor: OEHMARK OLLE
IPC: A01K1/12
Filed: 2003-05-14
Abstract: The present invention relates to a construction for an overhang (5) in a pit (1) of a milking parlour. The construction comprises a metal profile (2) fastened to the edge of the pit (1), and a reinforcement strut (6) mounted to said profile (2) in order to support an overhang (5) attached to said profile (2). The invention provides more space in the pit (1) for mounting of milking related equipment.
Patent CA-2488706-A1 (CA)
Title: Packaged commodity dispensing device
Inventor: ATSUTA JUNICHI
IPC: G07F11/62
Filed: 2003-06-30
Abstract: An object is to provide a packaged goods delivering device (100) easy to repair its packaged goods delivering machines (10) and designed to simplify the filling and exchange of packaged goods. To this end, it comprises a packaged goods delivering machines (10) for delivering packaged goods, a fra me (20) adapted to have the packaged goods delivering machines (10) fitted therein from the front, and a fixing means for fixing the packaged goods delivering machines (10) as fitted in the frame (20).
Patent CA-2489211-A1 (CA)
Title: A removable wheel attachment device for snow floats and the like
Inventor: PAQUIN MICHEL
IPC: E01H5/02
Filed: 2004-12-03
Abstract: The present invention discloses a removable wheel attachment device for a snow float (snow scoop), or the like to enable its use as a material, debris or goods transportation wheelbarrow or a snow float equipped with wheels when removable wheel attachment device is attached to it;  or as an ordinary snow float when wheels are not attached to it. The attachment method used provides for quick and simple attachment-detachment of the removable wheel attachment device that requires no special tools.
Patent CA-2490171-A1 (CA)
Title: Subcutaneous self attaching injection port with integral fasteners
Inventor: CONLON SEAN P
IPC: A61F5/00
Filed: 2004-12-13
Abstract: A self attaching injection port has integral fasteners extending from the housing, fixed relative thereto. The fasteners include one way fasteners, such as formed by a plurality of axially spaced concentrically aligned frustroconical annular flanges. The injection port is self attaching upon the surgeon applying a distal force to the injection port housing, causing the fasteners to penetrate the tissue, engaging the tissue to hold the injection port in place.
Patent CA-2491651-A1 (CA)
Title: Device for fixing an object on a vertical rod
Inventor: MOUFFLET CLAUDE
IPC: A47F5/08
Filed: 2003-06-26
Abstract: The article (37) is fastened to the rod (1), and the rod is fastened to a support such as a ceiling or a wall, by fastener means each comprising two parts (4, 19) that lock together around the rod.