baber/WOPTO huggingface dataset:
Patent DE-69820054-T2 (DE)
Inventor: SOEDERLIND HANS
IPC: C07K16/44
Filed: 1998-01-26
Granted: 2004-09-09
Abstract: The present invention relates to a method for in vitro creation of molecular libraries evolution of protein function. Particularly, it relates to variability and modification of protein function by shuffling polynucleotide sequence segments. A protein of desired characteristics can be obtained by incorporating variant peptide regions (variant motifs) into defined peptide regions (scaffold sequence). The variant motifs can be obtained from parent DNA which has been subjected to mutagenesis to create a plurality of differently mutated derivatives thereof or they can be obtained from in vivo sequences. These variant motifs can then be incorporated into a scaffold sequence and the resulting coded protein screened for desired characteristics. This method is ideally used for obtaining antibodies with desired characteristics by isolating individual CDR DNA sequences and incorporating them into a scaffold which may, for example, be from a totally different antibody. <IMAGE>
Patent DE-69820633-T2 (DE)
Inventor: SALVEMINI DANIELA
IPC: A61P25/36
Filed: 1998-06-15
Granted: 2004-09-23
Abstract: Synthetic low molecular weight catalysts for the dismutation of superoxide are potent analgesics that are effective in elevating the pain threshold in hyperalgesic conditions such as arthritis, and also operate to prevent or reverse tolerance to opioid analgesics.
Patent DE-69830150-T2 (DE)
Inventor: HUSSON DANIEL
IPC: F16B12/40
Filed: 1998-06-09
Granted: 2006-02-23
Abstract: The assembly node consists of two half-shells (1) which are bolted together and have edge recesses (2) and/or holes (3) for inserting and locking the ends of tubes (4,5). The tube ends are fixed inside the node by separate nuts and bolts (10) which pass through holes (7) in one half shells and in the tube ends inside them. The nuts fit into hexagonal sockets in the opposite half-shell to the bolts.
Patent DE-69837160-T2 (DE)
Inventor: IDDAN GAVRIEL J
IPC: A61B5/00
Filed: 1998-12-15
Granted: 2007-11-22
Abstract: An energy saving method for acquiring in vivo images of the gastro-intestinal tract is provided. A device, such as an autonomous capsule, includes at least one imaging unit; a control unit connected to the imaging unit and a power supply connected to the control unit. The control unit includes a switching unit and an axial motion detector connected to the switching unit. The axial motion detector detects the axial movement of the device and if the axial acceleration is below a pre-determined threshold, disconnects the power supply thereby preventing the acquisition of redundant images. A method for operation and use of the device is provided.
Patent DE-69902516-T2 (DE)
Inventor: PRASAD R
IPC: C09K3/16
Filed: 1999-01-29
Granted: 2003-07-24
Abstract: Static dissipative, high pressure decorative laminate having a surface resistivity in the static dissipative range even at relative humidities as low as 10 % is made by indorporating conductive sub-micron powder in an amount of about 7-10 % by weight based on total resin solids in the decore sheet, along with small amounts of ionic salt and humectant such as glycerin or an aliphatic tertiary amine.
Patent DE-69903778-T2 (DE)
Inventor: ESCHER SINA DOROTHEA
IPC: A23L27/60
Filed: 1999-08-11
Granted: 2003-07-17
Abstract: A compound of formula wherein R represents a hydrogen atom or an acetyl group, is useful in perfumery and in the field of flavors. The compound of formula (I) confer an odor and flavor effect extremely powerful of the clary-sage type, even when used in small amounts.
Patent DE-69903819-T2 (DE)
Inventor: ROSO PAOLO
IPC: A23G3/02
Filed: 1999-07-19
Granted: 2003-09-04
Abstract: A process is disclosed for the subdivision of a relatively elastic and gummy food product shaped as a continuous tape or string (14), which is extruded or laminated, and advancing at a predetermined speed on a conveyor (15), into a plurality of single portions (14', 14'') which are separated from one another by a predetermined distance (X). The cutting operation of said tape or string (14) is carried out by at least one blade (31, 31'), which is suitable for penetrating into the mass of the tape or string (14) and for causing the detachment of a portion (14', 14'') of the tape or string itself. The blade (31, 31'), follows a predetermined trajectory (50) comprising a first stretch (51) wherein said tape or string is cut, a second stretch (52) along the same advancement direction of the tape or string, a third stretch opposite to the advancement direction of the tape or string (14). Moreover the blade runs along said second stretch (52) at a higher speed than that of advancement of the tape or string (14); along said second stretch (52) the blade (31, 31') stays in contact with the edge of the portion (14', 14'') of tape or string in order to separate the portion itself of tape or string by a predetermined distance (X).
Patent DE-69905493-T2 (DE)
Inventor: HEBRANK H
IPC: G01N33/08
Filed: 1999-12-23
Granted: 2003-12-18
Abstract: A method of injecting a plurality of bird eggs comprises: (a) orienting a plurality of avian eggs in a predetermined position; (b) forming an opening in the shell of each of the eggs; (c) extending an elongate delivery device through each of the openings and into the eggs, each of the delivery devices comprising a detector and an injection needle, with the injection needle having a lumen formed therein; (d) detecting with the detector information from the interior of each of the plurality of eggs; and (e) injecting a substance into each of the plurality of eggs through the lumen of said injection needle. The detected information can be used for a variety of purposes, including adjusting the depth of penetration of the injection needle to more precisely control the location of the injection, identifying the gender of the eggs for subsequent sorting of the eggs, distinguishing viable from non-viable eggs, etc. When used for controlling depth penetration, the method positions the needle tip for any purpose, including withdrawing biological material as well as injecting substances. Apparatus, particularly high-speed apparatus, for carrying out the method is also disclosed.
Patent DE-69907060-T2 (DE)
Inventor: WILKINS PETER RAVENSCROFT
IPC: H05B1/02
Filed: 1999-03-02
Granted: 2004-02-26
Abstract: A temperature sensing and limiting device is described for use in a radiant electric heater (8) incorporating at least one heating element (14). The device comprises an elongate tubular housing (1) adapted to at least partly traverse the heater so as to be heated externally by the heating element. A component (4) is provided within the housing and provides an electrical parameter which changes as a function of temperature. At least a thermal-sensing portion (11) of a thermally-responsive bimetallic cut-out device (10) is provided within the housing (1), the cut-out device being adapted to deenergise the heater (8) at a predetermined temperature. <IMAGE>
Patent DE-69907636-T2 (DE)
Inventor: DEN HARTOG A
IPC: A61P25/14
Filed: 1999-02-05
Granted: 2004-03-25
Abstract: The present invention relates to a group of novel 2-aminoquinoline derivatives which are potent and selective agonists of the dopamine D4-receptor. The compounds have general formula (I) wherein (R1)n represents 1 or 2 substituents, which can be the same or different, from the group C1-3-alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino, and mono- or dialkyl (C1-2)amino, or two groups R1 at adjacent carbon atoms together with the benzene ring may form the benzdioxane group or benzofuran group, X represents nitrogen or carbon, and the dotted line may represent a double bond, (R2)p represents 0, 1 or 2 substituents, which can be the same or different, from the group methyl and ethyl, or (R2)p is a methylene bridge or ethylene bridge, R3 is hydrogen or methyl, and (R)m represents 0, 1, or 2 substituents, which can be the same or different and can be located at all available positions of the quinolyl group, from the group C1-3-alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino, and mono- or dialkyl (C1-2)amino, on the understanding that R1 cannot represent o-OCH3 when X is nitrogen, (R2)p and R3 are hydrogen, m is 0 and n is 1
Patent DE-69908942-T2 (DE)
Inventor: GRANGER MAURICE
IPC: A47K10/36
Filed: 1999-04-06
Granted: 2004-05-19
Abstract: A drum includes a hub defining in its central part a ring acting as a point for fixing and adjusting the cylindrical portion of the drum along variable positions by defining a variation in the material length strip format. The cylindrical portion of the drum is arranged in two parts capable of having a movement spacing one from the other by elastic deformation of one of the cylinder parts so as to define the drum circumference and the format variation, the parts capable of being mutually locked in position.
Patent DE-69911011-T2 (DE)
Inventor: SMITH JAMES
IPC: C12Q1/68
Filed: 1999-06-15
Granted: 2004-06-24
Abstract: There is disclosed a compound of formula (I) wherein each of X1 and X2 are independently NH-A-NR1R2, and wherein A is A C2-8 alkylene and R1 and R2 are independently selected from hydrogen, C1-4 alkyl, C2-4 hydroxy-alkyl and C2-4 aminoalkyl, or R1 and R2 together form a C2-6 alkylene group which with the nitrogen atom to which R1 and R2 are attached forms a heterocyclic ring, or an N-oxide derivative thereof, and wherein the compound (I) or its N-oxide derivative is optionally in the form of an acid salt derived from an organic or inorganic acid. Also disclosed is a method of its production and its uses, including its use in analyzing a cell or biological material and detecting the emitted fluorescence signal.
Patent DE-69913005-T2 (DE)
Inventor: LEHTONEN KAI
IPC: F02M53/02
Filed: 1999-06-07
Granted: 2004-08-26
Abstract: A control and safety valve arrangement in a fuel feeding system of an internal combustion engine, especially a large diesel engine, in which fuel is pumped from a fuel tank at least to one common pressure accumulator unit (1) and is fed therefrom under high pressure for injection into at least two cylinders of the engine. The pressure accumulator unit (1,1a) is connected to the fuel tank by means of a separate return flow line (5,6,7) which is provided with valve means having two separate control arrangements operationally independent of each other so that the pressure accumulator unit (1) can be connected to the fuel tank by means of a first control arrangement under the influence of a separate control pressure when necessary and in addition by means of a second control arrangement if the pressure in the pressure accumulator unit (1) exceeds a certain selected limit value. <IMAGE>
Patent DE-69913538-T2 (DE)
Inventor: JONSSON LARS
IPC: B21B37/28
Filed: 1999-12-23
Granted: 2004-09-30
Abstract: A method for controlling flatness of a strip (1) of rolled material rolled to a first flatness target and coiled and that is subsequently uncoiled, and a system which employs the method. Measurements of the flatness of the strip (1) during rolling are compared to both the first flatness target and to a second flatness target, a Mill Flatness Target 2. A flatness target for each of one or more subsequent processes, a Post Rolling Flatness Target (PRFT) and a measured flatness error is used to adapt a control signal for a mill stand (5) to control and regulate the flatness of subsequent production of rolled material of the same specification. The adaption may be made using different statistical techniques including fuzzy logic and neuro-fuzzy logic control methods. In the preferred embodiment, flatness measurements after decoiling are also fed forward to at least one subsequent process 12 and used to adapt control signals to regulate flatness of the current strip in the subsequent process 12. The advantages include that the rolled strip is more flat after decoiling, and that flatness control over the strip in a subsequent process is more accurate. <IMAGE>
Patent DE-69915349-T2 (DE)
Inventor: BOSY J
IPC: B26B21/22
Filed: 1999-12-28
Granted: 2005-02-10
Abstract: A shaving razor including a handle and three blade units each connected to the handle by a respective mounting structure that provides a pivotal connection of the blade unit to the mounting structure about a pivot axis that is transverse to the cutting edge, and also provides controlled up and down movement of the blade unit thereby permitting each said blade unit to conform to the contour of a surface being shaved. The handle has an index finger indent on a top surface, and thumb indent on the bottom surface, and is shaped to match the curvature of a user's hand.
Patent DE-69916328-T2 (DE)
Inventor: BLASCO JEAN-MICHEL
IPC: B65G69/04
Filed: 1999-01-20
Granted: 2005-05-04
Abstract: This device comprises an element driven in rotation about a vertical axis, placed at an outlet of a passage used for introducing a divided solid material into a receptacle. The element comprises two conduits for dispersing the material, each having a curved shape and an opening through which the material can flow out into the receptacle. The conduits are curved about an axis perpendicular to an axis of rotation of the element but in opposite directions from one another. Each of the conduits further comprises at least one longitudinal partition extending over a length of the conduit.
Patent DE-69929076-T2 (DE)
Inventor: LINDSAY JAMES
IPC: B05B7/06
Filed: 1999-10-20
Granted: 2006-08-03
Abstract: A low volume-low pressure spray gun (10) for spraying a fluid has a housing (12), a gas input (16), a trigger valve mechanism, and a nozzle (14). The gun (10) has lower and upper air passages (38, 39) which connect the gas input (16) to the trigger valve mechanism (23), and the trigger valve mechanism to the nozzle (14), respectively. The upper passage (39) is offset from the lower passage (38) and is substantially conical in shape, the layout of the passages (38, 39) producing a gas vortex in the upper passage (39) which creates a gas acceleration to compensate for the low pressure of the gas entering the gas input (16). The trigger valve mechanism comprises a piston valve (23), a liquid control needle valve (22), and a trigger (40). The piston valve (23) may include inner and outer apertured sleeves (26a, 26b), the sleeves being co-axial with the inner sleeve (26a) located inside the outer sleeve (26b). The inner sleeve (26a) is rotatably adjustable relative to the outer sleeve (26b) so that the apertures (61, 62) of the sleeves (26a, 26b) may be aligned, partially aligned, or closed, thus permitting adjustment of the gas vortex.
Patent DE-69936059-T2 (DE)
Inventor: YLIKOSKI JUKKA
IPC: A61K31/553
Filed: 1999-09-24
Granted: 2008-01-24
Abstract: Methods for preventing or treating damage to sensory hair cells and cochlear neurons are disclosed. The methods comprise the administration of an effective amount of a compound of Formula I or Formula II. The method provides for the prevention/treatment of both hearing loss and loss of the sense of balance.
Patent DE-69936201-T2 (DE)
Inventor: SHULTZ JOHN W
IPC: C12N9/12
Filed: 1999-06-23
Granted: 2008-02-07
Abstract: The present invention provides methods and compositions for protein stabilization, particularly the stabilization of polymerases in aqueous solutions with cationic surfactants. The present invention further provides cationic surfactants, including polyethoxylated amines, that stabilize thermostable and thermolabile enzymes in solution. These surfactants stabilize the activity of various enzymes, including thermostable DNA polymerases, thermolabile DNA polymerases and reverse transcriptases.
Patent DE-69938079-T2 (DE)
Inventor: DANNER BERNARD
IPC: C08L91/06
Filed: 1999-06-16
Granted: 2009-01-29
Abstract: Aqueous dispersions (L) comprising: a) a wax which is (a1) a carboxyl-containing hydrocarbon wax or a mixture of such waxes or a mixture of (a1) and, (a2) at least one unmodified hydrocarbon wax; (b) a (co)poly(meth)acrylamide or (co)poly-(meth)acrylamide mixture which is (b1) at least one macro(co)poly-(meth)acrylamide, which optionally contains carboxyl-containing comonomers, having an average molecular weight <o>M</o>W = n.10<6>, where n >/= 10, or a mixture of (b1) and (b2) at least one (co)poly(meth)-acrylamide, which optionally contains carboxyl-containing comonomers, having an average molecular weight <o>M</o>W < 10.10<6>, and (d) a dispersant system consisting of amphoteric, anionic and/or nonionic surfactants, are surprisingly useful as highly effective crease mark inhibitors having an extremely surfacy effect and are also suitable for particularly short liquors, for example in winch becks and jet-dyeing machines.
Patent HU-E026817-T2 (HU)
Title: Horizontal mixer with center-angled blades
Inventor: WORLEY MARK D
IPC: B01F29/63
Filed: 2011-07-07
Abstract: A horizontal mixer (50) is disclosed. Multiple blades (92) are affixed to and rotate with a tumbler (80) of the mixer (50). These blades (92) extend within an interior mixing chamber (90) and are center-angled so as to promote a desirable mixing action within this chamber (90) (e.g. so as to fold a slurry within the chamber (90) onto itself). One characterization is that the blades (92) are oriented so as to direct a flow toward a common outlet region (78) within the tumbler (80) throughout at least a certain rotational angle. The mixer (50) is particularly suited for realizing a desirable homogeneity of particles within a slurry from which radioisotopes may be produced.
Patent HU-E032739-T2 (HU)
Title: Recombinant elastase proteins and methods of manufacturing and use thereof
Inventor: FRANANO F NICHOLAS
IPC: C12N9/66
Filed: 2008-12-04
Abstract: The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for producing therapeutically useful elastase proteins, as are pharmaceutical compositions comprising said elastase proteins. Novel recombinant elastase proteins and protein preparations are also disclosed. Methods are described for treating and preventing diseases of biological conduits using pharmaceutical compositions containing the elastase proteins of the invention.
Patent TR-200001852-T2 (TR)
Inventor: HUEBENER ACHIM
IPC: C09J11/00
Filed: 1998-12-14
Abstract: An adhesive containing a) a compound containing at least one vinyl ether group which has a molecular weight of more than 400 and b) a photoinitiator which initiates a polymerization of component A after exposure to light with a wavelength of 100 to 600 nm is useful for the production of a film laminate.
Patent TR-200002909-T2 (TR)
Title: Rekombinant potivirüs yapısı ve kullanımı
Inventor: GAL-ON AMIT
IPC: A01N63/00
Filed: 1999-03-30
Abstract: Mevcut bulus; bitki çapraz korumasi için faydali olan, rekombinant potivirüs bulastirici bir nükleik asit, tercihen cDNA veya RNA yapisi ile ilgili olup, bahsedilen yapi; HC-Pro geni korunan FRNK kutusu dizisinin, bir substitüsyonu, tercihen Arg'nin bir substitüsyonunu içermesiyle karakterize edilen tam uzunlukta bir klondan olusmaktadir. Tercihen, bahsedilen yapi; ayrica, afid transmissibilitesini etkili olarak durduran bir substitüsyon içermektedir. Bunun yaninda, mevcut bulus; yukarida bahsedilen yapidan faydalanarak, potivirüsün ilimli bir türünün üretimi için bir metot  ve viral enfeksiyondan bitkileri korumak için ve bahsedilen yapiyi kullanarak, bitkilerde, yabanci nükleik asit (genlerinin) kisa süreli verilmesi için bir metot ile ilgilidir. Tercihen mevcut bulus; ZYMV enfeksiyonuna karsi, curcurbitlerin çapraz korunmasi için bir metot ile ilgilidir. Bundan baska, mevcut bulus; bitkileri, mekanik asilama veya bombardiman yoluyla, rekombinant potivirüs ..(devami var)
Patent TR-200200453-T2 (TR)
Inventor: OKEL TIMOTHY A
IPC: C08L21/00
Filed: 2000-08-17
Abstract: Described are fillers, e.g., inorganic oxides, that have been modified to have a carbon content of greater than 1 weight percent, a sulfur content of greater than 0.1 weight percent, a Silane Conversion Index of at least 0.3 and a Standard Tensile Stress @ 300% elongation of 7 or more. Polymeric compositions that contain such modified fillers are also described.
Patent DE-602004000563-T2 (DE)
Inventor: SICARD THIERRY
IPC: B01J8/00
Filed: 2004-04-07
Granted: 2007-01-25
Abstract: A gas flow diffuser (1), designed to be installed inside a generally cylindrical metal vessel, comprises a series of spaced plates (1A) in line with the axis of an inlet gas flow. Each plate has a circular hole (1B) centered on the axis, with the areas of the holes reducing along the line of the flow. The first plate of the diffuser is located at a distance from the vessel's inner wall, and it is held in place by connectors extending from the plate spacers. It can also be supported by one or two crosspieces.
Patent DE-602004005808-T2 (DE)
Inventor: XU PEI REN
IPC: H01R12/51
Filed: 2004-12-17
Granted: 2008-01-10
Abstract: An electrical connector having an electrically non-conductive carrier, the carrier having a plurality of contact pin mounting holes extending there through. Each hole has a square cross-section. An electrically conductive contact pin is passed through each hole. Each contact pin has a generally cylindrical shape with a leading pin section, a trailing pin section, and a contact head at the end of the trailing pin section. A retainer is provided on the pin separating the leading pin section from the trailing pin section. The trailing pin section has a length slightly longer than the length of the hole and a diameter slightly less than the width of the hole. The retainer and the contact head both have a diameter at least slightly greater than the width of the hole to retain the pin in the hole. <??>An electrical contact pin for use with a multi pin electrical connector adapted to be surface mounted on a printed circuit board. The contact pin is generally cylindrical in shape and has a leading pin section, a trailing pin section, and a retainer integral with the pin and located between the leading pin section and the trailing pin section. A contact head is provided at the free end of the trailing pin section. The retainer is in the form of a collar with a leading conical portion adjacent the leading pin section and a trailing cylindrical portion adjacent the trailing pin section. <??>A method of inserting an electrically conductive, cylindrical, contact pin into a square hole on a non-electrically conductive carrier, the contact pin having a leading pin section with at least a portion having a diameter slightly greater than the width of the hole and a retainer behind the leading pin section having a diameter greater than the diameter of the portion of the leading pin section. The method comprises pushing the leading pin section into and through the hole to initially deform the hole, and continuing to push the pin to move the retainer through the hole to complete deformation of the hole to be able to pass the retainer through the hole. <IMAGE>
Patent DE-602004013042-T2 (DE)
Inventor: TIEFENAUER LOUIS
IPC: G01N33/68
Filed: 2004-11-15
Granted: 2009-05-14
Abstract: An assay chip (2) for investigation the functionality of membrane proteins and their interactions with molecules, comprising: a nanopore array (7) having a plurality of nanopores (8) in a suitable support layer (6) deposited on said nanopore substrate(28) being a substantially planar support layer (6) having a plurality of nanopores (8) corresponding with said nanopores of said nanopore substrate(28); a biological effective layer (4) being;capable to host at least a non-lipid molecule or functional molecule, deposited on said support layer (6) and covering the plurality of nanopores (8), resulting in accesible nanopores from both sides of the biological effective layer (4) for measurement or imaging. The invention provides a structured support that allows to generate a biological effective membrane, such as a lipid bilayer membrane, having high and reliable stability in a manner that its fluidity is sustained in order to keep integrated membrane proteins in said lipid bilayer in its full biological functionality. <IMAGE>