Patent KR-100804096-B1 (KR)
Title: Cosmetic composition for cleansing containing enzyme capsules stabilized in the highly concentrated surfactant system and the process for preparing thereof
Inventor: KIM JI YEONG
IPC: A61K8/66
Filed: 2006-08-31
Granted: 2008-02-18
Abstract: An enzyme capsule formulation is provided to block effectively the inside swelling thereof caused by water and a highly concentrated surfactant at the concentration of more than 15% and maintain the activity of an enzyme inside thereof when included in a skin washing composition, thereby showing excellent skin washing and skin keratin removing effects. An enzyme capsule formulation comprises a seed consisting of white sugar or microcrystalline cellulose; an enzyme layer formed on the seed and consisting of an enzyme-stabilized microcapsule; a first coating layer formed on the enzyme layer and consisting of shellac; a second coating layer formed on the first coating layer and consisting of a polymer; a third coating layer formed on the second coating layer and consisting of wax; a fourth coating layer formed on the third coating layer and consisting of a cationic surfactant; a fifth coating layer formed on the fourth coating layer and consisting of a polymer; a sixth coating layer formed on the fifth coating layer and consisting of an anionic surfactant; and a seventh coating layer formed on the sixth coating layer and consisting of a polymer, where the enzyme stabilized microcapsule is a triple structured microcapsule consisting of an enzyme as an inner core such as lipase, amylase, pepsin, trypsin, urease, asparaginase and a hydrolase of papain; a hydrophobic polyol having the molecular weight of at least 1,000g/mol as a coating material of the enzyme such as polyethyleneglycol, polypropylene glycol and a copolymer thereof; and a polymer wall agent at the outermost thereof such as poly-L-lactic acid, poly-D,L-glycolic acid, poly-L-lactic acid-co-glycolic acid, poly-D,L-lactic acid-co-glycolic acid, polycaprolactone, polyvalerolactone, polyhydroxy butyrate, polyhydroxyvalerate, a copolymer prepared from poly o-ester and a monomer thereof, polystyrene, poly p- or m-methylstyrene, poly p- or m-ethyl styrene, poly p- or m-chlorostyrene, poly p- or m-chloromethylstyrene, poly styrene sulfonic acid, poly p- or m- or t-butoxy styrene, poly methyl(meth)acrylate, polyethyl(meth)acrylate, polypropyl(meth)acrylate, poly n-butyl(meth)acrylate, poly isobutyl(meth)acrylate, poly t-butyl(meth)acrylate, poly 2-ethylhexyl(meth)acrylate, poly n-octyl(meth)acrylate, polylauryl(meth)acrylate, polystearyl(meth)acrylate, poly 2-hydroxyethyl(meth)acrylate, polyethyleneglycol(meth)acrylate, methoxy polyethyleneglycol(meth)acrylate, polyglycidyl(meth)acrylate, poly dimethylaminoethyl(meth)acrylate, poly diethylaminoethyl(meth)acrylate, polyvinylacetate, polyvinylpropionate, polyvinylbutyrate, polyvinylether, polyallylbutylether, polyallylglycidylether, poly(meth)acrylic acid, polymaleic acid, polyalkyl(meth)acrylamide and poly(meth)acrylonitrile, and the formulation consists of 20-45 parts by weight of the whiter sugar or microcrystalline cellulose; 0.1-30 parts by weight of the enzyme stabilized microcapsule; 5-30 parts by weight of the shellac; 5-30 parts by weight of the polymer, 5-30 parts by weight of the wax, 1-10 parts by weight of the cationic surfactant; and 1-10 parts by weight of the anionic surfactant. A composition for washing skin or removing skin keratin comprises the enzyme capsule formulation.