baber/WOPTO huggingface dataset:
Patent NZ-716462-A (NZ)
Title: Optically active pde10 inhibitor
Inventor: ZUTA CHARLES PRINCE
IPC: C07D307/46
Filed: 2014-09-10
Abstract: Disclosed herein is a process for the synthesis of the compounds of formula II-a, in particular the compound (S)-1-(5- (4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone, the process comprising: converting boronic acid A1 to carbaldehyde B1 through activation of the boronic acid with an activating reactant A2; converting carbaldehyde B1 to acetal C1 under acid catalysis with a suitable source of orthoformate; converting acetal C1 to nitrile D1 through catalyzed cyanation with a metal catalyst and a cyanide source; hydrolyzing D1 with a suitable acid to give carboxylic acid E1; converting carboxylic acid E1 to amide F1 with a suitable base, a suitable coupling reagent, and a source amine; converting amide F1 to a compound of Formula (II) with an anionic coupling reagent having structure H1, separating a compound of Formula (II-a) from a compound of Formula (II-b) by chiral HPLC; and optionally converting the compound of Formula (II-a) to a salt.
Patent NZ-717977-A (NZ)
Title: Anti-twist liner and shell for a dairy animal teat cup assembly
Inventor: HEDLUND NATHAN
IPC: A01J5/08
Filed: 2014-09-09
Abstract: A milker unit teat cup assembly (16) for dairy animals having a shell (18) and liner (22) combination that resists twisting by the liner barrel relative to the shell using a recess (40) in the liner (22) that is engaged by a key (52) in the shell (18).
Patent NZ-718954-A (NZ)
Title: Powdered nutritional composition with large lipid globules
Inventor: ARAKAKI CECILIA
IPC: A23L33/00
Filed: 2014-11-07
Abstract: The invention pertains to powdered nutritional compositions comprising large lipid globules and micronized carbohydrate or carbohydrate microcrystals. Preferably the nutritional composition is an infant or follow on formula or a growing up milk. The invention also pertains to the use of micronized carbohydrate or carbohydrate microcrystals for improving flow and reducing cohesiveness of a powdered nutritional composition with large lipid globules.
Patent NZ-719163-A (NZ)
Title: Co-crystals of (s)-n-methyl-8-(1-((2’-methyl-[4,5’-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors
Inventor: KADIYALA IRINA
IPC: A61P35/00
Filed: 2014-10-17
Abstract: The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. The co-crystals of (S)-N-methyl-8-(1-((2’-methyl-[4,5’-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide with adipic acid are DNA-dependent protein kinase (DNA-PK) inhibitors which may be useful for the treatment of cancer.
Patent NZ-722423-A (NZ)
Title: Method for reducing total gas production and/or methane production in a ruminant animal
Inventor: MACHADO LORENNA
IPC: A61K36/04
Filed: 2015-01-21
Abstract: The present application relates to animal feed and feed supplements comprising red marine macroalgae species. The present application also relates to methods of reducing total gas production and/or methane production in a ruminant animal by administering red marine macroalgae species, or by administering feed or feed supplements comprising red marine macroalgae. Particularly, the present invention relates to a method for reducing total gas production and/or methane production in a ruminant animal by administering a species of Asparagopsis.
Patent NZ-726263-A (NZ)
Title: Primer coating composition
Inventor: MARTZ JOHNATHAN T
IPC: C09D167/00
Filed: 2015-04-17
Abstract: The present invention relates to a primer coating composition that includes, (a) a (meth)acrylic polymer that includes hydroxyl groups, and which has a Tg of at least 30C. The primer coating composition further includes, (b) a polyester that includes hydroxyl groups, and which has a weight average molecular weight of less than 3000, and a hydroxyl value of at least 100. The primer coating composition also includes, (c) a crosslinking agent having at least two isocyanate groups. The present invention also relates to a coated article that includes a repaired area that includes a primer coating formed from the primer coating composition of the present invention. The primer coating compositions, in accordance with some embodiments, provide reduced or minimal ringing defects.
Patent NZ-727600-A (NZ)
Title: Bispecific t cell activating antigen binding molecules
Inventor: AST OLIVER
IPC: C07K16/28
Filed: 2015-08-03
Abstract: The present invention generally relates to bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. These bispecific antigen binding molecules comprise: (a) a first Fab molecule which specifically binds to a first antigen; (b) a second Fab molecule which specifically binds to a second antigen, and wherein the variable domains VL and VH of the Fab light chain and the Fab heavy chain are replaced by each other; (c) a third Fab molecule which binds specifically to the first antigen; and (d) an Fc domain composed of a first and second subunit capable of stable association; wherein the first antigen is a target cell antigen and the second antigen is a activating T cell antigen; and wherein the third Fab molecule under c) is identical to the first Fab molecule under a); wherein the CL and CH1 domains of the first and third Fab molecules are modified as defined; and wherein the CH3 domain of the first subunit of the Fc domain comprises a protuberance and the CH3 domain of the second subunit of the Fc domain comprises a cavity (”knob in hole” structure). In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease, such as cancer.
Patent NZ-734798-A (NZ)
Title: Polypeptides
Inventor: CROWE SCOTT
IPC: C07K16/24
Filed: 2016-03-31
Abstract: There is provided inter alia a polypeptide comprising an immunoglobulin chain variable domain which binds to TNF-alpha, wherein the immunoglobulin chain variable domain comprises three complementarity determining regions (CDR1-CDR3)and four framework regions (FR1-FR4), wherein CDR1-CDR3 and FR1-FR4 are as defined in the specification.
Patent NZ-735340-A (NZ)
Title: Afterburners including methods of making and operating
Inventor: FINNERTY CAINE
IPC: H01M8/0662
Filed: 2016-03-04
Abstract: An afterburner comprising a stack of apertured, compressible, resilient, refractory layers comprising silica, alumina or silica-alumina fibres, where the apertures which may be coated with a combustion catalyst provide a torturous path through the stack, a method of making the afterburner, and a fuel cell with the afterburner. The use of compressible and resilient layers allows for the thermal expansion of other adjacent components, for example, a fuel cell stack of a fuel cell unit, can be accommodated by the afterburner.
Patent NZ-737851-A (NZ)
Title: T-cell receptor specific antibodies
Inventor: SCHENDEL DOLORES
IPC: C07K16/28
Filed: 2016-06-01
Abstract: The present invention relates to an antibody or binding fragment thereof that binds to a fraction of T cell receptor variable alpha (TCR Vα) chains comprising at least two different TCR Vα chains but less than all TCR Vα chains or that binds to a fraction of T cell receptor variable beta (TCR Vβ) chains comprising at least two different TCR Vβ chains but less than all TCR Vβ chains.
Patent NZ-746338-A (NZ)
Title: Use of alphavirus and zap inhibitor in the preparation of an antitumor drug, and antitumor drugs comprising the same
Inventor: YAN GUANGMEI
IPC: C12N15/86
Filed: 2015-08-24
Abstract: Disclosed is use of an alphavirus and a ZAP inhibitor in preparation of antitumor drugs for the treatment of a human tumour, and to antitumor drugs comprising the same. The alphavirus is M1 virus or Getah virus. In addition, the specific tumor types sensitive to abovementioned alphavirus treatment are further determined, so as to provide a safe and effective solution for antitumor drug treatment regimes.
Patent NZ-755788-A (NZ)
Title: Process for producing coated particles
Inventor: FUNDA ELGER
IPC: A61K9/50
Filed: 2018-02-16
Abstract: The present patent application relates to coated particles. These coated particles show improved properties when used in compressed tablets. More specifically, the present application relates to a process for the production of coated particles having a core and a coating layer surrounding the core, wherein the process comprises the steps of: (a) forming cores of the coated particles by introducing into a top spraying device 40 wt-% 95 wt-%, based on the total weight of the coated particles, of a core material which consists of: (i) at least 20 wt-%, based on the total weight of the solid particles, of at least one fat soluble vitamin, (ii) at least one emulsifier, and (iii) at least one non-reducing sugar, (b) introducing into the top spraying device 5 wt-%-60 wt-%, based on the total weight of the coated particles, of a coating system which comprises at least one wax and/or at least one fat selected from the group consisting of carnauba wax, candelilla wax, sugarcane wax and hydrogenated palm oil, and (c) operating the top spraying device to spray a molten form of the coating system onto the cores to thereby form the coated particles each comprised of a core formed of the core material and a deformable coating layer having an irregular thickness and a plurality of vacuoles formed of the coating system surrounding the core, wherein the top spraying device is operated throughout steps (a) – (c) at an atomizing air pressure of I bar and an atomizing air temperature of 100 to 1200 C.
Patent PT-104867-A (PT)
Title: Colchão de grande conforto dotado de coberturas de tufo laminado
Inventor: SOLANS ALFONSO SOLANS
IPC: A47C27/00
Filed: 2009-12-10
Abstract: A PRESENTE INVENÇÃO REFERE-SE A UM COLCHÃO DE GRANDE CONFORTO DOTADO DE COBERTURAS DE TUFO LAMINADO E SÃO CONSTITUÍDAS POR DUAS CAMADAS DE TELA LAMINADA E UMA CAMADA DE ESPUMA DE POLIURETANO, UNIDAS ENTRE SI POR UMA COSTURA QUE PERCORRE TODO O SEU PERÍMETRO NA PROXIMIDADE DOS SEUS REBORDOS, COM A PARTICULARIDADE DE SOBRE ESTE SUBCONJUNTO DE TUFO LAMINADO SE DISPOR DE UMA CAMADA ADICIONAL DE CONFORTO, ESTANDO PREVISTO QUE ESTAS COBERTURAS SE SITUEM SOBRE A SUPERFÍCIE DE UM COLCHÃO E CONSTITUIR UM MEIO QUE MELHORA AS QUALIDADES DO PRÓPRIO COLCHÃO, PROPORCIONANDO TAMBÉM UM EFEITO VISUAL NO COLCHÃO QUE SIMULE A COLOCAÇÃO DE UMA ALMOFADA.
Patent PT-105778-A (PT)
Inventor: BERNHARDT CATHERINE
IPC: B65D75/30
Filed: 2011-06-30
Abstract: The device (10) has a support comprising a friction pad (32) made from adhering material e.g. elastomer such as polyurethane. A thin plastic material film (28) of an envelope is applied against a contact surface (34) of the friction pad. The thin film is rubbed against the contact surface by a user for facilitating separation of another thin plastic material film (30) of the envelope and the former thin film to open the envelope. The friction pad is fixed on a front wall (16) of the support in a detachable manner, where the front wall is parallel to a base wall (12).
Patent PT-105908-A (PT)
Title: Reactor para síntese química com aquecimento óhmico, método e suas aplicações
Inventor: CAVALEIRO JOSE ABRUNHEIRO DA SILVA
IPC: B01J19/00
Filed: 2011-09-27
Abstract: PRESENTE INVENTO REFERE-SE A UM REACTOR COM AQUECIMENTO ÓHMICO PARA SÍNTESE QUÍMICA. ESTE MÉTODO DE AQUECIMENTO TEM APLICAÇÃO DESDE A SÍNTESE ORGÂNICA À INORGÂNICA, PREPARAÇÃO DE MATERIAIS ORGANO-METÁLICOS, SÍNTESE DE NANOPARTÍCULAS E DE POLÍMEROS. A PRESENTE INVENÇÃO DIMINUI O CONSUMO DE ENERGIA E AUMENTA O RENDIMENTO DAS REACÇÕES DE SÍNTESE QUÍMICA, POR MEIO DE UM REACTOR PARA SÍNTESE QUÍMICA, E RESPECTIVO MÉTODO, O QUAL COMPREENDE: - UM DEPÓSITO PARA OS REAGENTES (1), O QUAL CONTÉM PELO MENOS UMA TUBULADURA LATERAL (1A); - UMA TAMPA (3), ESTA TAMPA DEVERÁ SER DE PREFERÊNCIA RESISTENTE A ATAQUES QUÍMICOS E A SOLVENTES ORGÂNICOS; - DOIS ELÉCTRODOS (3A,3B) PARA PRODUZIR AQUECIMENTO ÓHMICO DO MEIO REACCIONAL, CONFIGURADOS PARA PRODUZIR UMA CORRENTE ELÉCTRICA COM FREQUÊNCIA SUPERIOR A 15 KHZ. O PRESENTE INVENTO É APLICÁVEL, NA INDÚSTRIA QUÍMICA E NA INDÚSTRIA FARMACÊUTICA EM PARTICULAR EM PROCESSOS DE SÍNTESE QUÍMICA.
Patent PT-106688-A (PT)
Title: Sistema de geração de energia eléctrica através do aproveitamento eólico do movimento dos comboios em marcha
Inventor: PEQUENO RICARDO JORGE HORTA
IPC: F03D9/32
Filed: 2012-12-10
Abstract: O SISTEMA APRESENTADO PERMITE A GERAÇÃO DE ENERGIA ELÉCTRICA FAZENDO O APROVEITAMENTO DO MOVIMENTO DOS COMBOIOS EM MARCHA.TRATA-SE DE UM SISTEMA A SER UTILIZADO NO SECTOR FERROVIÁRIO E QUE PODE COMPREENDER A SUA MONTAGEM NAS MAIS DIVERSAS TIPOLOGIAS DE MATERIAL CIRCULANTE, NOMEADAMENTE: LOCOMOTIVAS, UNIDADES MOTORAS E REBOQUES DE PASSAGEIROS, CARRUAGENS E VAGÕES.É UM SISTEMA QUE FUNCIONA ATRAVÉS DO DESLOCAMENTO DO COMBOIO EM MARCHA DE SERVIÇO, APROVEITANDO A FONTE EÓLICA PROPORCIONADA POR ESSA MARCHA, NOS MAIS DIVERSOS REGIMES DE TRABALHO/EXPLORAÇÃO DOS COMBOIOS EM SERVIÇO, SENDO QUE A ENERGIA ELÉCTRICA GERADA SERÁ APROVEITADA PARA A ALIMENTAÇÃO DE TODOS OS EQUIPAMENTOS E DISPOSITIVOS ELÉCTRICOS EXISTENTES NOS COMBOIOS, EXCEPTO O CIRCUITO DE TRACÇÃO.
Patent RU-94019249-A (RU)
Inventor: OVCHINNIKOV I G
IPC: F28D20/00
Filed: 1994-05-12
Abstract: FIELD: engine engineering. SUBSTANCE: heat accumulator has outer housing 1 inside which is inner housing 2 with heat accumulating substance. Between the inner housing and outer housing is insulated low-pressure space 3. Pipe lines 4 and 5 are connected with the housing at the inlet and outlet, respectively. Pipe lines 6 for heat carrier, charging and discharging the accumulator pass through housings 1 and 2 and insulating space 3. Pipe lines 6 are extensions of pipe lines 4. The inner housing 2 is suspended with respect to the outer one with the use of spiral pipe lines 6. EFFECT: improved design.
Patent RU-94022264-A (RU)
Inventor: MING S TANG
IPC: A61K6/838
Filed: 1992-11-24
Abstract: FIELD: medicine. SUBSTANCE: the present invention includes novel compositions and methods for use of calcium amorphous compounds such as amorphous calcium phosphate, amorphous calcium phosphate-fluoride, amorphous calcium carbonate-phosphate, amorphous calcium carbonate- phosphate-fluoride and amorphous calcium fluoride in remineralization and fluorination of teeth. These amorphous compounds or solutions which form amorphous compounds when applied to tooth tissue of inside it prevent and/or stop teeth diseases such as dental caries, exposure of tooth roots and dental sensitivity. These compounds of all calcium phosphates in physiological conditions are characterized by the highest solubility, maximum rates of formation and conversion into apatite. In addition, in the presence of fluoride the amorphous compound quickly converts into fluoride containing apatite. EFFECT: higher efficiency.
Patent RU-94026027-A (RU)
Inventor: KIRIK D L
IPC: C12M1/04
Filed: 1994-07-13
Abstract: FIELD: medicine; microbiology, particular, methods for separation and cultivation of microaerophilic bacteria CAMPYLOBACTER applicable in investigation of clinical material from human beings and animals, and separation of these pathogens from environmental objects. SUBSTANCE: in preparation of pack, racemic acid is used to accelerate oxygen absorption and to prevent evolving of carbon dioxide gas and oxygen absorption before placing the moistened pack into anaerostat, use is made of sealed packing of two-layer gas impermeable water-proof-paper with optimal ratio of components in reaction mixture. EFFECT: provision of optimal microaerophilic medium for campylobacteria in cultivation under anaerostatic conditions, increased sensitivity of cultivation of campylobacteria and increased efficiency of their separation , lower cost of pack due to reduced number of components in reaction mixture , reduced level of diarrhea diseases due to application of the offered pack by public health establishments.
Patent RU-94028326-A (RU)
Inventor: ZINOV EVA V A
IPC: D04B21/14
Filed: 1994-07-27
Abstract: FIELD: knitting. SUBSTANCE: loop wales of the warp of the reverse sides of opposite located single-faced knit are intersecting, and horizontal wales formed by the weft yarn of each knit are located to overlap the convergent sections of two adjacent intersecting wales of warp loops of opposite knit. EFFECT: higher quality due to strong fastening of weft yarn and increased fixation of one single-faced knit with respect to the other.
Patent RU-94035753-A (RU)
Inventor: KHANS BISSMANN
IPC: B65B25/14
Filed: 1994-09-29
Abstract: FIELD: publishing. SUBSTANCE: series of N sheets with prints of securities (N, for example, is 100), is checked against fault prints. Positions of sheets of securities which contain faults are stored in computer memory. Then sheets of this series run through numbering machine 4 which has numbering units controlled by computer. Number sequence is set so that all prints of sheets of securities without faults with respect to their printing quality receives uninterrupted number sequence . In addition sequence of numbers of N sheets of securities in same position of sheet follows number sequence of N sheets of securities in adjacent position of blank sheets of securities. Next sequence of numbers is generated. Then piles of sheets, each of which contains N sheets, are cut into piles of sheets of securities and said piles of blank sheets are stored according to their through numbers and are fed to device 9 which sorts and bundles them. Fault prints are removed in this process. N subsequent blank sheets of securities without faults with respect to their printing quality are bundled in pile bundles having complete number sequence. Ten bundles are packed into one pack of sheets of securities. EFFECT: increased functional capabilities.
Patent RU-94036267-A (RU)
Inventor: DUZHIKH F P
IPC: F23J11/00
Filed: 1994-09-28
Abstract: FIELD: heat-power engineering. SUBSTANCE: holes at pitch of 3 to 5 m are cut in one of stack envelopes and heat-insulating composition is introduced through these holes by means of compressed air at a rate of up to 70 m/s checking simultaneously the level of filling and absence of voids. In case there are no voids, holes are stopped with tampons made of sealing material. EFFECT: enhanced reliability.
Patent RU-94041211-A (RU)
Title: Catalyst solution
Inventor: JUDZHIN SHUSTOROVI
IPC: C07D411/04
Filed: 1993-02-24
Abstract: FIELD: production of catalyst solution. SUBSTANCE: catalyst solution has one or several compounds of metal catalyst and organic solvent taken from group, composed of glycol derivative, alkylpyrrolidone and alkosiethyl ether. In the case solution is not introduced with additional chloride-bearing compounds. Metal is chosen from group of platinum, rhenium and rhodium. Compounds are taken from group composed of HHPtCl•6HO, ReRe(CO), ReReO. LiLiReOand PhClPhCl•4HO. Catalytic solutions are useful in processes of motor car engines exhausted pollutions and similar substances conversion. Most advantageous catalytic solution has three metals: platinum, rhenium and rhodium. EFFECT: catalytic solutions are effectively used in processes of pollutions conversion.
Patent RU-94042408-A (RU)
Inventor: GERAN SUNDKHOL M
IPC: A62C37/14
Filed: 1994-01-31
Abstract: FIELD: fire-fighting equipment. SUBSTANCE: spraying head includes rod element 33 pressed against inlet hole of spraying head by such force of spring 22 that it keeps inlet closed against rest pressure of installation but it displaces under action of working pressure of installation. EFFECT: simplified design and increased functional reliability. 4 dwg
Patent RU-95102616-A (RU)
Inventor: AZIMOV F I
IPC: E04G23/02
Filed: 1995-02-22
Abstract: FIELD: civil engineering. SUBSTANCE: first, frontal surfaces of building are cleaned out, exposed are butt joints of wall panels, reinforcement in butt joints, fastening of embracing framework to reinforcement and panels and reinforcement nets, then shotcrete operation is performed. Method restores load-bearing capacity of a building, improves heat engineering, architectural- decorative and operational characteristics of buildings and structures at relatively low cost. EFFECT: high efficiency.
Patent RU-95104237-A (RU)
Inventor: BOGOMAZOV V N
IPC: F41A9/00
Filed: 1995-03-23
Abstract: FIELD: small arms. SUBSTANCE: proposed invention is related to small-size submachine guns with location of magazine in grip. Increased firepower of weapon is achieved thanks to increased length of bore relative to length of weapon. For this purpose submachine gun is provided with mechanism for automatic feed of cartridges from magazine manufactured in the form of feed conduit, cartridge pusher which is coupled to gas pusher, lock preventing double loading and feeder of cartridge. Magazine is displaced to center of weapon relative to breech piece of barrel by one third of length of the latter. Principle of operation of automatics is release of gases from bore. Submachine gun is fitted with shoulder rest to fire from various positions which, while folded, presents front grip. EFFECT: increased firepower of proposed submachine gun.
Patent RU-95104320-A (RU)
Inventor: GREGORI A SKOTT
IPC: F16L25/01
Filed: 1995-03-24
Abstract: FIELD: mechanical engineering. SUBSTANCE: method comprises making a flexible hose preferably provided with the conducting outer surface. A metal ring is at first fitted on the end of the hose. The fitting is squeezed at the end of the hose by compression of the metallic bushing of the fitting around the end of the hose and a portion of the fitting mounted inside the inner space of the hose. The ring is shifted back along the bushing whereas the uninsulated end of the grounding wire is received between the bushing and ring. The ring is then clamped about the bushing entraining the end of the grounding wire between them. EFFECT: enhanced reliability and simplified manufacturing.
Patent RU-95109172-A (RU)
Inventor: KUDRJASHOV L S
IPC: C14C1/02
Filed: 1995-06-02
Abstract: FIELD: leather industry. SUBSTANCE: in the process of dehydration, skins are proposed to be treated with industrial-frequency current. To that end, after skins are scrubbed on their flesh side, they are covered with uniform layer of zeolite and antiseptic, subjected to current action for 5-7 min, conditioned for 1.5-2 days, and after removal of zeolite are deposited in storehouse. EFFECT: accelerated skin preservation process.
Patent RU-95109477-A (RU)
Inventor: GOLOVANCHIKOV A B
IPC: C04B28/14
Filed: 1995-06-06
Abstract: FIELD: production of light-weight building materials. SUBSTANCE: proposed material is produced by mixing together solid carbon dioxide with gypsum binder and tempering water. Solid carbon dioxide having particle size up to 1 mm is obtained by throttling liquid carbon dioxide from initial pressure 50-60 atm down to 1 atm. Solid carbon dioxide is added into tempering water simultaneously with gypsum binder in form of gypsum having half-molecule of water. Method can be used for producing cellular aerated concretes, aerated mortars and aerated gypsums. It can be used in building practice, in industrial and civil construction for manufacturing light-weight structural elements, such as partitions, wall panels and blocks possessing superior heat-insulating properties and low density. EFFECT: enhanced strength of porous building material; lower solid carbon dioxide consumption.