baber/WOPTO huggingface dataset:
Patent CR-20210522-A (CR)
Title: Bioconjugates of e. coli o-antigen polysaccharides, methods of production thereof, and methods of use thereof
Inventor: POOLMAN JAN THEUNIS
IPC: A61P13/02
Filed: 2020-03-18
Abstract: A bioconjugate of an <em>E. coli</em> glucosylated O4 antigen polysaccharide covalently linked to a carrier protein and compositions thereof are provided. Also provided are recombinant host cells for producing the bioconjugate, and methods of producing the bioconjugate using the recombinant host cells. The recombinant host cells contain a nucleic acid encoding a glucosyl transferase capable of modifying the <em>E. coli</em> O4 antigen with glucose branching to produce the glucosylated O4 antigen polysaccharide. Bioconjugates of an <em>E. coli</em> glucosylated O4 antigen polysaccharide described herein can be used alone or in combination with one or more additional <em>E. coli </em>O-antigen polysaccharides to induce antibodies against an <em>E. coli</em> glucosylated antigen, and to vaccinate a subject against extra-intestinal pathogenic <em>E. coli</em> (ExPEC).
Patent CR-20220376-A (CR)
Title: Monoacylglycerol lipase modulators
Inventor: GARCIA-REYNAGA PABLO
IPC: C07D413/08
Filed: 2021-02-09
Abstract: 3.1.0 and 4.1.0 Azabicycle compounds of Formula (I), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions. Wherein X, Y, R<sup>1</sup>, R<sup>2a</sup>, and R<sup>2b</sup> are defined herein.
Patent CR-20230119-A (CR)
Title: Flt3 ligand fusion proteins and methods of use
Inventor: MOUSSION CHRISTINE CARINE
IPC: C07K19/00
Filed: 2021-08-05
Abstract: The invention provides an effectorless immunoglobulin Fc protein, fusions of the effectorless Fc protein to a Flt3 ligand, and methods of using the same.
Patent CR-20230449-A (CR)
Inventor: BERLIN MICHAEL
IPC: A61P1/12
Filed: 2022-03-19
Abstract: Compuestos bifuncionales, de fórmula PTM-L-CLM, donde la CLM es de fórmulas al-a4, la PTM f fórmula PTM-IA y L es un ligando. Estos compuestos actúan sobre varias enfermedades a través del agonismo sobre LRRK2 y la ubiquitina ligasa de cereblon E3.
Patent EC-SP003845-A (EC)
Title: Derivados de nitrilo como inhibidores de catepsina k
Inventor: WALLBAUM SABINE
IPC: A61K31/19
Filed: 2000-12-21
Abstract: La presente invención se refiere a compuestos de fórmula (I) En donde R1 a R7 e Y son tal como se definen en la descripción y las reivindicaciones, y las sales farmacéuticamente aceptables y/o ésteres farmacéuticamente aceptables de los mismos. Los compuestos son útiles para el tratamiento de enfermedades que estén asociadas con las proteasas cisteínicas, tales como la osteoporósis, osteoartritis, artritis reumatoide, metástasis tumoral, glomerulonefritis, arterosclerosis, infarto de miocardio, angina de pecho, angina de pecho inestable, embolia, rotura de placa, ataques isquémicos transitorios, amaurosis fugax, enfermedad oclusiva de las arterias periféricas, restenosis después de angioplastia y colocación de stents, formación de aneurismo aórtico, inflamación, enfermedades autoinmunes, malaria, citopatía del tejido del fondo ocular, y enfermedades respiratorias.
Patent EC-SP099800-A (EC)
Title: Producción de aceite en microorganismos
Inventor: TRIMBUR DONALD E
IPC: C12M1/00
Filed: 2009-12-14
Abstract: La invención proporciona métodos y composiciones útiles para la producción de aceites, combustibles, oleoquímicos y otros compuestos en microorganismos. En particular, la invención proporciona microorganismos portadores de aceite y métodos de cultivo a bajo costo de tales microorganismos. La invención también proporciona células microbianas que contienen genes exógenos que codifican, por ejemplo una lipasa, transportador de sacarosa, sacarosa invertasa, fructocinasa, una enzima polisacárido-degradante, acil-ACP tioesterasa grasa, acil-CoA/aldehído reductasa grasa, acil-CoA reductasa grasa, aldehído reductasa grasa, aldehído descarbonilasa grasa y/o una proteína portadora de acilo. La invención también incluye métodos para la manufactura de combustible de transportación tales como diesel renovable, biodiesel y combustible de jet renovable.
Patent EC-SP982611-A (EC)
Title: Preparados de aerosoles acuosos que contienen macromoleculas biologicamente activas y procedimiento para la generacion de aerosoles correspondientes
Inventor: MONTAGUE MEADE CRISTOPHER JOHN
IPC: A61K38/21
Filed: 1998-08-03
Abstract: El presente invento se refiere a preparados de aerosoles acuosos que contienen macromoléculas biológicamente activas para la generación de aerosoles inhalables sin ningún gas propulsor.
Patent EC-SP992844-A (EC)
Title: Metodo y dispositivo para secar productos o tratarlos con calor
Inventor: WEFFERS MICHAEL
Filed: 1999-02-01
Abstract: La invención se refiere a un método y a un dispositivo para secar o tratar con calor sustancias o productos a una presión diferente de la presión atmosférica. Además, la invención se refiere a la obtención mediante este método de tajadas de banana desecadas y polvo de bananas hecho a partir de las mismas. Para el secado o el tratamiento con calor, los productos a secar se introducen en recipientes de transporte, los que luego se introducen a la cá,ara de tratamiento, pasando por cámaras de carga de tipo esclusa y se retiran de la cámara de tratamiento pasando por cámaras de descarga de tipo esclusa. Dentro de la cámara de tratamiento se encuentra por lo menos una fuente microondas. Además puede prverse una fuente de rayos infrarrojos. Después del tratamiento con calor o secado puede preverse un periodo de descanso. Especialmente para el caso de que este periodo de descanso sea más prolongado, se prevé un dispositivo de avance vertical dentro de la cámara de tratamiento. El recipiente de transporte es en forma de bandeja y puede presentar redes, sobre las cuales se coloca el producto. El método se utiliza preferentemente para secar o tratar con calor material primas alimenticias, por ejemplo alimentos o sustancias activas para productos farmacéuticos.
Patent EC-SP992929-A (EC)
Title: Compuestos triciclicos sustituidos (caso x-12143)
Inventor: SAWYER JASON SCOTT
IPC: C07D209/80
Filed: 1999-04-16
Abstract: Se describen una clase de nuevos compuestos tricíclicos junto con el uso de tales compuestos para inhibir la liberación de ácidos grasos mediada por sPLA2 para el tratamiento de afecciones como el choque séptico.
Patent FI-20002190-A (FI)
Inventor: ORTAMALA TAPIO HEIKKI
IPC: E01H5/06
Filed: 2000-10-05
Abstract: A method of snow plough from a site using a snowplough with at least two plough blades (5) forming together a ploughing angle and there being on the ploughing site fixed objects, such as airport lamps (1), rising over the site surface. In the method, when the snow plough faces an object, the plough front end is opened and the area, with the object on it, left un-ploughed by the open front end, is cleaned by means of brushes (6, 7) in the rear of the plough front end.
Patent FI-20031267-A (FI)
Inventor: PIIPPO ANTTI
IPC: H02P25/02
Filed: 2003-09-05
Abstract: A method for determining the speed and position of a rotor of a salient-pole permanent magnet synchronous machine, the method comprising the steps of creating a voltage model (41) on a permanent magnet synchronous machine, forming a voltage reference (u s,ref ) for a stator of the permanent magnet synchronous machine, determining stator currents (i s ) of the permanent magnet synchronous machine, calculating a rotor angular speed (42) from the voltage reference (u s,ref ) and the stator currents (i s ) using the voltage model (41). The method further comprises the steps of forming with signal injection a position tracking signal (µ)of the rotor of the permanent magnet synchronous machine, forming a rotor angular speed estimate ( É    m  )from the calculated rotor angular speed (42) and the rotor position tracking signal (µ), forming a rotor position angle estimate (¸   m  ) from the formed rotor angular speed estimate (É   m  ) and the rotor position tracking signal (µ).
Patent FI-20175402-A (FI)
Title: Method for stimulating plant disease suppressive activity in sphagnum moss, related products and uses
Inventor: NÄKKILÄ JUHA
IPC: H01B3/18
Filed: 2017-05-08
Abstract: A method for stimulating plant disease-suppressive activity, such as soil- and seed-borne fungal diseases- and saprophytic moulds-suppressive activity, in Sphagnum moss biomass is provided. In said method freshly harvested and/or air-dried Sphagnum biomass is heat treated, thereupon a flow of air heated to a temperature within a range of 50-80 °C is conveyed thereto during a predetermined period of time. Sphagnum biomass is preferably selected from naturally occurring Sphagnum species, in particular, Sphagnum fuscum. A plant disease-suppressive growing medium and uses thereof are further provided.
Patent FR-1601069-A (FR)
Title: 3-(disubstituted methylene) pyrrolidines
IPC: C07D207/20
Filed: 1967-08-08
Granted: 1970-08-10
Abstract: Cpds. of formula (I): (where R = H, alkyl, phenylalkyl, substd. phenylalkyl, cycloalkyl, phenoxyalkyl, phenylaminoalkyl or substd. phenyl; R1 = alkyl, phenylalkyl, cycloalkyl, phenyl or substd. phenyl; R2 = phenyl or substd. phenyl, and R is not Me when R1 = R2 = phenyl), possess antidepressant activity.
Patent FR-1603612-A (FR)
Title: Crimped thermoplastic synthetic filament - continuous production
IPC: D02G1/16
Filed: 1968-08-23
Granted: 1971-05-10
Abstract: Crimped thermoplastic synthetic filament continuous production In a stretch and heat treatment comprising the steps in series of feeding the filament to feed rolls, stretching the filament, ejecting by gaseous fluid the stretched filament, relaxing the filament on a perforated surface while setting the crimps thus formed and finally removing the processed filament for further operations.
Patent GB-1050069-A (GB)
IPC: G21C19/105
Abstract: 1,050,069. Lifting nuclear fuel elements. BABCOCK & WILCOX Ltd. Sept. 24, 1965 [Sept. 24, 1964], No. 40827/65. Heading B8H. When a nuclear fuel element 21, supported by a device 1, is set down, pivoted jaws 13 are forced open against springs 14 by a plunger 6 which is depressed against a spring 9 by the weight of a member 4. The plunger 6 has a conical end 10 which bears against projections 17 on the jaws 13 to push them apart. As this happens a flange 22 on the element 21 is released from ledges 18. The projections 17 come to rest above shoulders 10a and are held in this position when the grab is subsequently raised. As the raising progresses the flanges 22 bear against sloping surfaces 15 and separate the jaws so far that the projections 17 clear the shoulders 10a, thus allowing the plunger 6 to be returned by the spring 9. To pick up a further element the device is lowered over it and the flanges 22 push the levers 13 apart by bearing on surfaces 16. Springs 14 may be omitted.
Patent GB-1050630-A (GB)
IPC: H03K19/173
Abstract: 1,050,630. Character recognition. INTER NATIONAL BUSINESS MACHINES CORPORATION. Jan. 7, 1965 [Feb. 5, 1964], No. 672/65. Heading G4R. An adaptive logic system as in Specification 1,050,627 includes a means for suppressing a random selection of the digital inputs during the conditioning operation. Random numbers are generated by a noise source such as a Zener diode, amplified and passed through a register wherein they may be staticized during the suppression operation. The random numbers are shifted through the register by a multivibrator providing positive and negative-going pulses after suitable shaping. Operation of a conditioning key conditions a trigger to supply a low-frequency multivibrator which gates the synchronizing pulses for the shift register and de-energizes current gates connected to the register to staticize it during the conditioning and cut off a random selection of emitter followers connected to the matrix expansion circuit. The apparatus may also contain reverse tare weight units as described in Specification 1,050,629.
Patent GB-1052015-A (GB)
IPC: G11C17/04
Abstract: 1,052,015. Read-only stores. INTERNATIONAL BUSINESS MACHINES CORPORATION. July 9, 1963 [Sept. 4, 1962], No. 33825/62. Heading G4A. In a read-only store the sense conductors comprise a plurality of conductor pairs providing inputs to differential amplifiers, and balancing conductors connected at one end to an associated drive conductor are electrically coupled to the sense system in such a way that energization of the latter gives substantially no output from the appropriate differential amplifier. In the embodiment shown in Fig. 1 (not shown) a drive line (say D2) is selected by pulsing a transistor G2 which causes line L2 to fall almost to earth potential. By now pulsing transistor T1 a signal passes along line D2 and via the prearranged data-representing capacitative couplings to sense lines S1 S2 and S3. By virtue of balancing conductors B1, B2 and B3, the differential amplifiers respond only to the pulses from T1 and not to the selecting, pulses from G1 . G3. Instead of capacitative data couplings, inductive elements, Fig. 4 (not shown), could be used.
Patent GB-1053358-A (GB)
IPC: A01B15/10
Abstract: 1,053,358. Agricultural implements. INTERNATIONAL HARVESTER CO. Nov. 25, 1965 [Nov. 25, 1964], No. 50097/65. Heading A1B. A plough with an adjustable mouldboard is provided with a stay 5 between the mouldboard 4 and a landside 3 and an eccentric coupling 8 which comprises a stud rotatable in a hole in the stay and eccentrically pivoted to the mouldboard.
Patent GB-1053711-A (GB)
IPC: D07B3/10
Abstract: 1,053,711. Wire stranding machines. EDMANDS CO. Feb. 12, 1964 [March 20, 1963], No. 5980/64. Heading D1T. A stranding machine of the kind having a source A, a closing die D, and a double twist mechanism B includes one or more stepped capstans in the area C to deliver strands to the closing die D. The capstans contact a sufficient length of the wires to prevent slip of the wires and are of stepped formation so that as the wires are twisted and taken up the correct amount will be led into the closing die D to prevent buckling or kinking of the wires. A motor 23 drives the capstans 53, 55 and cradle 11, and a separate motor 12 drives the take up reel 10. Reference has been directed by the Comptroller to Specification 912432.
Patent GB-1054741-A (GB)
IPC: A61F13/14
Abstract: 1,054,741. Belts. HAWKSLEY & SONS Ltd. May 3, 1965 [Feb. 3, 1964], No. 4508/64. Heading A3V. [Also in Division A5] One end of a belt formed of woven nylon material is passed through a rigid loop 2 on the other end and the belt is fastened by interengagement of strips 4 and 5 of filamentary hooks and eyes. A further loop 3 is preferably provided on the first belt end. In use, to prevent pain during coughing, the fastening strips are engaged, with the belt an easy fit around the chest, until the need to cough arises when the strips are separated by pulling the loop 3 outwardly, the belt is tightened by pulling on loops 2 and 3 and the strips 4 and 5 are re-engaged.
Patent GB-1054890-A (GB)
IPC: F16D69/02
Abstract: 1,054,890. Natural resin composition. FERODO Ltd. (Soc. Anon. Francaise du Ferodo). Aug. 19, 1965, No. 35662/65. Heading C4D. [Also in Divisions C3 and D1] A composition used in the impregnation of friction linings (see Division D1) comprises ethylene, oiticica oil, rosin, GRS rubber, sulphur and carbon black.
Patent GB-1119200-A (GB)
Abstract: 1,119,200. Igniter plugs. GENERAL MOTORS CORP. June 22, 1967 [June 29, 1966], No. 28903/67. Heading F1B. An igniter plug has an outer shell 12 of a metal resistant to the conditions in which the plug is to operate, a metal sleeve 16 arranged within the shell with one end hermetically sealed to the shell and a fused mass of glass 34 arranged in the other end of the sleeve and hermetically sealed to the sleeve, the glass and the metal of the sleeve having substantially the same co-efficient of thermal expansion. The rod 32 is of metal having substantially the same co-efficient of thermal expansion as the glass. The rod and sleeve may be made of a low co-efficient of expansion iron based alloy. Other metals or alloys having a co-efficient of expansion similar to that of glass may be used. Molybednum or tungsten may be used. The insulator 22 is preferably made of high alumina base material containing at least 85% aluminium oxide.
Patent GB-1143702-A (GB)
IPC: C07D307/88
Abstract: 1,143,702. Photographic diazotype development processes. ADDRESSOGRAPH-MULTIGRAPH CORP. March 11, 1966 [March 18, 1965], No. 10800/66. Headings G2C and G2A. Imagewise exposed two-component diazotype materials are developed by applying up to 3 grams per square metre of an alkaline liquid developer to the material. The developers are preferably the amine compositions of divisional Specification 1, 143, 703. As shown, the liquid developer 32 is placed in trough 30 and is picked up by roller 22. A controlled quantity of liquid is transferred by roller 24 which oscillates between rollers 22 and 26. The controlled amount of developer is then transferred to roller 28 covered with a rubber blanket and contacted with exposed sheet 38, pressure being maintained by metal roller 36. The developer liquid or the sheet may be heated if desired.
Patent GB-1226662-A (GB)
IPC: F42B10/64
Filed: 1968-05-01
Abstract: 1,226,662. Controlling aircraft. NORDAVIATION SOC. NATIONALE DE CONSTRUCTIONS AERONAUTIQUES. 1 May, 1968 [5 May, 1967], No. 20721/68. Heading B7G. A flying vehicle (e.g. a missile) is controlled by a control element (e.g. as control surface or thrust spoiler) which is oscillated for a predetermined period after take-off at a first frequency at least twice the natural frequency of the element so that the element has no resultant effect and thereafter at a lower second frequency, the controlling influence of the element depending on its mean position. Apparatus to effect this may include two oscillators 5, 6 providing the first and second frequencies connected via a switch 4 to a controller 7 to give an output 10 (e.g. of square wave form) the switch 4 receiving a signal from a timing circuit 1 at the end of the predetermined period. The signal to the switch 4 may be delayed at an AND gate 3 by a detector 2 (e.g. a differentiator) until the beginning of a square wave at 10.
Patent GB-1226829-A (GB)
IPC: C01G17/04
Filed: 1968-09-18
Abstract: 1,226,829. 829. Epitaxial Deposition of Germanium. INTERNATIONAL BUSINESS MACHINES CORP. Sept.18, 1968 [Oct.11, 1967], No.44302/68. Heading C7F. Germanium is deposited epitaxially on a semiconductor substrate from a gas stream including a disproportionable Ge halide which deposits Ge such that the rate of its deposition is surface limited. The halide is preferably Gel 2 , and the substrate may be Ge, GaAs, or Si, and prior to plating may be chemically polished, rinsed, and dried. H 2  from 38 and/or He from 37 pass either through halogen source 40 or halogen hydride generator 39, entraining halogen or halogen hydride in the gas stream which passes to Ge source area 12, and reacts at 550-900‹ C. with Ge in 14 under chemical equilibrium conditions so that GeX 2  (X=Halogen) is formed, the amount thereof depending on the relative amounts of H 2 , He and X 2 . The gas mixture then passes to chamber 13 where the GeX 2  disproportionates to Ge and GeX 4 , depositing Ge on substrate 1 at 300-500‹C., held on vacuum chuck head 27. A dopant such as B or As may be added from BI 3  or AsH 3  vapour respectively. (For Figure see next page)
Patent GB-1227227-A (GB)
IPC: H05B3/00
Filed: 1968-08-27
Abstract: 1,227,227. Internal resistance heating. ALLMANNA SVENSKA ELEKTRISKA A.B. 27 Aug., 1968 [28 Aug., 1967], No. 40909/68. Heading H5H. An internal resistance billet heater comprises a billet holder 3 at each end, each holder 3 carrying contacts 25 which engage the billet end, contacts 26 which engage the billet sides and a clamping device 5, 6 which prevents axial forces exerted by the end contacts 25 from being transmitted to the portion of the billet between the clamping devices. In operation with the clamp jaws 5, 6 retracted a billet 1 is fed in the direction X to support rollers 24 until it makes contact with a raised sensing member 13 at the right heand end of the heater. The left hand sensing member 13 is then raised by a piston cylinder 16 acting via cranked lever 15 pivoted to a carriage 17. The left hand carriage 17 is then driven by its hydraulic device 22 until the sensing device 13 engages the left hand end of the billet. If desired, both sensing devices 13 may initially be in their lowered positions. The sensing devices are then lowered and the billet is clamped petween the hydraulically controlled clamps 5, 6. Finally the side contacts 26 and end contacts 25 are driven into engagement with the billet.
Patent GB-1229180-A (GB)
IPC: B23Q3/06
Filed: 1967-04-14
Abstract: 1,229,180. Work clamping. MOLINS MACHINE CO. Ltd. 11 April, 1968 [14 April, 1967], No. 46152/70. Divided out of 1,227,732. Heading B3B. A base member for securing a workpiece in position for a machining operation to be carried out comprises a fixing device housed in the base member at each of a plurality of locations arranged at the junctions of a square grid. Each fixing device 147 is spring-urged to protrude from the surface of the base member but is normally restrained from so protruding by a removable capping member 156. When a fixing device 147 is required at a particular location the capping member 156 is removed and a support element 157 screwed on to the end of a housing 152. The fixing device 147 passes through the support element 157 and can be screwed up into a tapped hole 160 in the workpiece 159.
Patent GB-1233883-A (GB)
IPC: G03F7/032
Filed: 1969-01-07
Abstract: 1,233,883. Photopolymerizable resin compositions. NIPPON PAINT CO. Ltd. 7 Jan., 1969 [22 Jan., 1968; 15 March, 1968], No. 942/69. Heading C3G. [Also in Division G2] A photopolymerizable resin composition consists of (1) 1À26 to 3À78 parts by weight of a monoester of a dihydric aliphatic alcohol with acrylic acid or methacrylic acid, (2) an aqueous solution of 1 part by weight of a partially hydrolysed polyvinyl acetate having a degree of hydrolysis of 95 to 60 mol. per cent and an average polymerization degree of 300 to 2000 or a methyl cellulose of an average polymerization degree of 160 having a hydropropoxy substituent, and (3) as a photopolymerization initiator, 1 to 5%, based on the weight of (1) and the polymer component in (2), of at least one uranyl salt, alone or together with 0À0072 to 0À72%, on the said basis, of azobisisobutyronitrile. A monofunctional acrylamide, e.g. acrylamide, methacrylamide or their N-methyl derivatives may be present in component (1) in which the ester may be beta-hydroxyethyl or -hydroxypropyl acrylate or methacrylate. Specified uranyl salts are the nitrate, acetate, sulphate, phosphate and dibutyl phosphate. In the examples, the resin compositions are aqueous solutions containing (a) partially hydrolysed polyvinylacetate and (i) beta-hydroxyethyl acrylate, or methacrylate, or beta-hydroxypropyl methacrylate, or a mixture of beta-hydroxyethyl methacrylate and acrylamide, and uranyl nitrate or (ii) beta-hydroxyethylmethacrylate, uranyl nitrate and uranyl sulphate or azobisdiisobutyronitrile, or (b) methyl cellulose, beta-hydroxyethyl methacrylate and uranyl nitrate. The compositions are used in the production of photopolymerizable resin sheets and printing plates (see Division G2), which are exposed to U.V. light.