baber/WOPTO huggingface dataset:
Patent CA-2661863-A1 (CA)
Title: Inhibitors for glyt-1
Inventor: NARQUIZIAN ROBERT
IPC: A61K31/167
Filed: 2007-08-20
Abstract: The present invention relates to compounds of the general formula I wherein R1 is lower alkyl, aryl or heteroaryl, wherein aryl and heteroaryl are optionally substituted by halogen, lower alkyl, lower alkoxy, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, cyano, amino, di-lower alkyl amino or morpholinyl; R2 is lower alkyl, -(CH2)n-aryl, -(CH2)n-heteroaryl or -(CH2)n-cycloalkyl, wherein the aryl or heteroaryl groups are optionally substituted by one or more substituents, selected from the group consisting of halogen, lower alkyl, cyano, or lower alkoxy; R3 is hydrogen or lower alkyl; R4 is aryl or heteroaryl, wherein at least one ring is aromatic in nature, wherein aryl and heteroaryl are optionally substituted by one or more substituents, selected from the group consisting of halogen, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, lower alkyl; X is a bond or -OCH2-; n is 0, 1 or 2; or to pharmaceutically acceptable acid addition salts thereof, with the exception of 4-methoxy-N-[2-oxo-2-(phenylamino)ethyl]-N-phenyl-benzamide, 4-chloro-N-[2-[(4-methylphenyl)amino]-2-oxoethyl]-N-phenyl-benzamide, 4-chloro-N-[2-[5-chloro-2-methoxyphenyl)amino]-2-oxoethyl]-N-benzamide, 4-methyl-N-(2-oxo-2-[(2,4,6-trichlorophenyl)amino]ethyl]-N-benzamide, N-[2-[(4-methylphenyl)amino]-2-oxoethyl]-N-phenyl-benzamide, 4-methyl-N-[2-[(4-methylphenyl)amino]-2-oxoethyl]-N-phenyl-benzamide, 4-chloro-N-(2-oxo-2-[(2,4,6-trichlorophenyl)amino]ethyl]-N-benzamide and N-[2-[(2, 4-dimethoxyphenyl)amino]-2-oxoethyl]-N-[(2-fluorophenyl)methyl]- benzeneacetamide. and to their use in the treatment of neurological and neuropsychiatric disorders.
Patent CA-2662274-A1 (CA)
Title: Chemical compounds
Inventor: BANKER PIERETTE
IPC: A61K31/496
Filed: 2007-08-31
Abstract: The present invention relates to certain indole derivatives that are modulators of PPAR, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine.
Patent CA-2663011-A1 (CA)
Inventor: LOFTESNESS DAVID E
IPC: G06F17/30
Filed: 2007-09-28
Abstract: A strategy is described for responding to a user's query based on a consi deration of the user's intent in entering the query (1 14). The user's inten t, in turn, is determined by examining prior query-related behavior of a pop ulation of users (128).
Patent CA-2665387-A1 (CA)
Inventor: LEE AMY S
IPC: A61P35/00
Filed: 2007-08-15
Abstract: The present application provides methods for detecting, diagnosing, monitoring, predicting responsiveness to therapeutic agents and staging cancer. The present application provides methods and compositions useful for suppression of GRP78 expression or activity in cancer cells to overcome resistance of certain therapeutic agents. The present application also provides methods for predicting whether a subject with cancer is at risk for developing resistance to certain therapeutic agents.
Patent CA-2665636-A1 (CA)
Title: Wet barrel fire hydrant system with second valve
Inventor: ROSE MATTHEW JESSE
IPC: E03B9/16
Filed: 2007-10-05
Abstract: Wet barrel fire hydrants (10) which feature additional structure for reducing the potential that those with ill intent can foul municipal water supplies by- introducing toxins or other materials into fire hydrants. Various embodiments include valves which close off portions of the hydrant or water conduit otherwise available for receipt of toxic or other materials when the fire hydrant nozzle cap is unscrewed and open and/or a pump is connected to the nozzle (14). Such valves preferably open automatically when water is flowing from the water supply through the nozzle (14), but close off portions of the barrel when the nozzle (14) is open and water is not flowing through the nozzle (14).
Patent CA-2666403-A1 (CA)
Title: Roll-your-own smokeable product
Inventor: FIEBELKORN RICHARD
IPC: A24C5/40
Filed: 2007-09-25
Abstract: A roll-your-own smoking article (10) made from a laminate of tobacco (2) and paper (1) which includes one or more layers of tobacco (2) adhered to one surface of the paper (1). At least two opposing edges (E1, E2) of the paper (1) are free from tobacco. The laminate (1) can be rolled to form a smoking article (10), wherein the smoking article (10) is produced by rolling about one of the tobacco free edges (E2) and where the other tobacco free edge (E1) fixes to the outside surface of the rolled smoking article (10) to retain it in the rolled form.
Patent CA-2668526-A1 (CA)
Inventor: MOIST STANFORD C
IPC: H01R4/36
Filed: 2009-06-11
Abstract: Disclosed herein is a submersible electrical set-screw connector. The submersible electrical set-screw connector includes a connector body section and a first sealing member. The connector body section includes a first opening and a second opening. The first opening is substantially perpendicular to the second opening. The first opening is adapted to receive a portion of an electrical conductor. The first sealing member is removably connected to the submersible electrical set- screw connector. The sealing member is adapted to receive the electrical conductor. The sealing member includes an outer cylindrical surface and an inner cylindrical surface. The outer cylindrical surface includes a first centerline axis. The inner cylindrical surface includes a second centerline axis. The first centerline axis is offset from the second centerline axis.
Patent CA-2672254-A1 (CA)
Inventor: BAYER ERWIN
IPC: B24C1/10
Filed: 2007-12-05
Abstract: The invention relates to a device for the surface peening, especially ultrasonic shot-peening of a partial element (36) of a component (10) of a gas turbine. According to said method, the partial element (36) and at least one surface (54) of a vibration device (56) impinging the blasting material are positioned relative to each other, the surface (54) of the at least one vibration device (56) and a sealing fin (36) being positioned relative to each other at an angle (.alpha.) between 70° and 90° based on the direction of extension (E) of the sealing fin. The invention also relates to a device for carrying out said method.
Patent CA-2672880-A1 (CA)
Inventor: JANG WAN YOUNG
IPC: A61C13/093
Filed: 2008-03-14
Abstract: The present invention relates to a dental prosthesis, and more particularly, to a screw- engagement type dental prosthesis which enables non-preparation of the natural tooth because it is manufactured by division into two pieces or three pieces, which can be simply installed, and in which the occlusal pressure can be uniformly dispersed. Also, the present invention relates to a method of casting a screw- engagement type dental prosthesis by using a bolt made of carbon or ceramics. Furthermore, a keeper and a body are engaged with each other via a bolt in a state where thin and semi -conical maintaining portions formed on inner inclination surfaces of abutment teeth of both sides with a small preparation are accurately engaged with keys formed on inner inclination surfaces of the keeper and the body in correspondence to the maintaining portions.
Patent CA-2673361-A1 (CA)
Inventor: FRANK MARKUS
IPC: C12N15/82
Filed: 2008-01-15
Abstract: The invention relates to a method of generating or increasing a pathogen resistance in plants by reducing the expression of at least one subtilisin polypeptide or a functional equivalent thereof. The invention relates to novel nucleic acid sequences coding for a Hordeum vulgare subtilisin (HvRNR9) and Triticum aestivum subtilisin (TaRNR9) polynucleotide and describes homologous sequences (RNR9) thereof, and totheir use in methods for obtaining a pathogen resistance in plants, and to nucleic acid constructs, expression cassettes and vectors which comprise these sequences and which are suitable for mediating a fungal resistance in plants. The invention furthermore relates to transgenic organisms, in particular plants, which are transformed with these expression cassettes or vectors, and to cultures, parts or transgenic propagation material derived therefrom.
Patent CA-2674758-A1 (CA)
Inventor: CONRAD WAYNE ERNEST
IPC: A47L5/32
Filed: 2009-07-30
Abstract: An upright surface cleaning apparatus comprises an anti-rotation locking mechanism that is automatically operably engaged when the upper section is moved into the storage position and is automatically operably disengaged when the upper section is moved into the floor cleaning position. In another embodiment, an upright surface cleaning apparatus comprises an anti-rotation locking mechanism that is engaged when the upper section is moved into the storage position and an alignment mechanism.
Patent CA-2678844-A1 (CA)
Inventor: ISHIKAWA KAZUO
IPC: H01M8/10
Filed: 2008-04-22
Abstract: Anode off-gas is intermittently introduced into an exhaust gas processing device (16) from a fuel cell (12). The exhaust gas processing device (16) discharges the anode off-gas after diluting it by dilution gas. The exhaust gas processing device (16) has a dilution container (25) and a partition plate (28) for partitioning the inside of the dilution container (25) into a first chamber (26) and a second chamber (27). The partition plate (28) has a gap (29) for connecting the first chamber (26) to the second chamber (27). The exhaust gas processing device (16) further has an exhaust section (32) provided in the first chamber (26), a dilution gas introduction section (30) provided at the first chamber (26), and an anode off-gas introduction section (31) provided at the second chamber (27).
Patent CA-2682548-A1 (CA)
Inventor: MEIJER JOHN
IPC: C08F4/00
Filed: 2008-03-31
Abstract: The invention relates to an accelerator solution comprising a complexing agent selected from the group consisting of complexing agents having a nitrogen atom and a hydroxyl group and bipyridine, a salt of a metal selected from the group consisting of transition metal, magnesium, and lithium, and optionally a solvent, wherein when the complexing agent has a nitrogen atom and a hydroxyl group, the amount of complexing agent in the accelerator solution is at least 5 wt%, based on the total weight of the accelerator solution, the amount of solvent is less than 50 wt%, and the amount of diethylene glycol as solvent is less than 25 wt%, based on the total weight of the accelerator solution.
Patent CA-2686173-A1 (CA)
Inventor: EVAN-ZOHAR OSHRI
IPC: A61F2/30
Filed: 2008-05-05
Abstract: An objective method and system for dynamic analysis of prosthesis- bound subjects for determining optimal prosthesis alignment adjustments consists o f a motion detection system, motion database, blending engine and algorithms , and a graphical user interface with suitable program controls whereby manu al, semi-automatic, or fully automated analysis of a prosthesis-equipped sub ject's motion performance can be done in real time to determine objectively the optimal adjustments for the subject's prosthesis in a precise clinical p rotocol context.
Patent CA-2687310-A1 (CA)
Inventor: NEURATH ALEXANDER ROBERT
IPC: A61K31/00
Filed: 2008-05-23
Abstract: A tablet for insertion into a vagina including 0.01 to 500 mg of a vaginal medication, such as a microbicide, such as cellulose acetate 1,2- benzenedicarboxylate (CAP); 100 to 500 mg of mannitol powder; 50 to 300 mg of inert microcrystalline cellulose; 10 to 80 mg of hydroxypropyl methylcellulose; 50 to 250 mg of glycerol and optionally 2 to 4 mg of at least one preservative which protects against microbicidal contamination and discourages the growth of yeast in the vagina. The tablet which includes CAP as the vaginal medication is vaginally administered before coitus in methods for preventing the sexual transmission of HIV- 1, HIV-2, herpesvirus, or an infection caused by Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, Haemophilus ducreyi or Treponema pallidum. The tablet which includes CAP as the vaginal medication is vaginally administered to prevent or treat bacterial vaginosis.
Patent CA-2687750-A1 (CA)
Inventor: HEINE NIKLAS
IPC: C07D239/95
Filed: 2008-07-03
Abstract: The present invention relates to substituted amino-quinazolinonesof general formula (I) wherein the groups R1 to R14 and A, are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.
Patent CA-2687834-A1 (CA)
Inventor: DUNCAN ROBERT HUME
IPC: B01J31/02
Filed: 2008-06-16
Abstract: The invention provides a method of carrying out a Lewis-acid catalysed organic reaction in the presence of a Lewis acid catalyst comprising a metal-organic compound having the following formula: M(HO(CR1 R2)z)a(O(CR1R2)z)bY-(CR3R4).chi.-Y((CR1R2)zO)c((CR1R2)zOH)d.nR5OH (Formula I) in which: M is a metal atom, preferably titanium, zirconium, hafnium or iron (III) Y is selected from P and N, but is very preferably N; each R1, R2, R3 and R4 is independently selected from H, alkyl, aryl, substituted alkyl or substituted aryl, R5 is hydrogen, an alkyl group, a hydroxy-functionalised alkyl group, a polyoxyalkylmoiety, R6O or R7COO where R6 and R7may each represent H, alkyl, aryl or alkyl-aryl; d and a are each O or 1, b and c are each 1 or 2, b + c = the valency of M, a+b+c+d = 4, each z is independently 1,2, 3 or 4; x represents the least number of C atoms between the Y atoms and is 2 or 3 and n is a number in the range from 0 to 4. The metal-organic compound forms a stable hydrate in water which retains Lewis-acid catalytic properties.
Patent CA-2690866-A1 (CA)
Inventor: GANE PATRICK A C
IPC: C02F1/28
Filed: 2008-06-06
Abstract: The present invention relates to a process for reducing the amount of organic components in water, wherein a surface--reacted naturalcalcium carbonate and a hydrophobic adsorbent, selected from the group consisting of talc, hydrophobised calcium carbonate, hydrophobised bentonite, hydrophobised kaolinite, hydrophobised glass, or any mixture thereof, are brought into contact with the water to be purified, the surface-reacted natural calcium carbonate being the reaction product of a naturalcalcium carbonate with an acid and carbon dioxide, which is formed in situ by the acid treatment and/or supplied externally, and the surface-reacted natural calcium carbonate being prepared as an aqueous suspension having a pH  of greater than 6.0, measured at 20°C.
Patent CA-2691353-A1 (CA)
Inventor: CAIZZA RICHARD J
IPC: A61M5/50
Filed: 2008-06-12
Abstract: A syringe assembly (100) having passive disabling structure includes a barrel (102) and a plunger rod assembly.  The plunger rod assembly includes a plunger rod (108) and a stopper (128) connected by an indexing locking element. The number of strokes of the syringe plunger before the stopper is locked into the barrel rendering the syringe assembly unusable is determined by the number of detents on the plunger rod and stopper which engage the locking mechanism (130). Upon completion of the final delivery stroke, any attempt to withdraw the plunger rod from the barrel will cause the locking element (130) to engage the barrel and trap the stopper (128) in the barrel preventing further use of the syringe.
Patent CA-2692564-A1 (CA)
Inventor: CRISCUOLO CHRISTOPHER J
IPC: A61F2/00
Filed: 2001-10-23
Abstract: A surgical fastener for securing surgical mesh material to body tissue, comprising a conical body portion having a pointed distal tip and an enlarged proximal head; and a helical thread extending radially from the conical body portion, wherein the helical thread commences at the distal tip and terminates at a distance spaced from the enlarged proximal head.
Patent CA-2693256-A1 (CA)
Inventor: HARRISON STEPHEN D
IPC: A61K38/08
Filed: 2008-04-07
Abstract: The disclosure herein relates to modified .gamma.PKC inhibitory peptides, methods of generating such peptides, and method for using .gamma.PKC inhibitory peptides for the treatment of pain.
Patent CA-2693383-A1 (CA)
Inventor: VAN SLYKE PAUL
IPC: A61K38/08
Filed: 2007-10-26
Abstract: The present invention provides a multimeric form of a Tie 2 binding peptide monomer, wherein the multimeric form has Tie 2 agonist activity. The multimeric form, preferably a tetramer, stimulates angiogenesis and promotes wound healing. The present invention also features pharmaceutical compositions comprising the multimeric Tie 2 agonists, including those suitable for topical or systemic administration. Methods of using the multimeric Tie 2 agonists of the invention for stimulating angiogenesis and for promoting healing of wounds, such as diabetic ulcers or skin grafts, are also provided.
Patent CA-2694616-A1 (CA)
Inventor: WIENER EITAN T
IPC: A61B17/32
Filed: 2008-07-24
Abstract: A surgical instrument includes a transducer configured to produce vibrations along a longitudinal axis at a predetermined frequency. The transducer includes a first end and a second end. A first resonator portion includes a first end coupled to the first end of the transducer. The first resonator includes a second end adapted to receive a first ultrasonic transmission waveguide. A  second resonator portion includes a first end coupled to the second end of the transducer. The second resonator includes a second end adapted to receive a second ultrasonic transmission waveguide.
Patent CA-2694659-A1 (CA)
Inventor: MIELKE MARK JOSEPH
IPC: F01D9/02
Filed: 2010-02-25
Abstract: A variable stator vane (15) airfoil (31) is mounted on a button (54) centered about a rotational axis (20) and includes circular leading and trailing edges (52, 53) circumscribed about the rotational axis (20) at a button radius (R) Contoured pressure and suction sides (58, 59) extend from the circular leading edge (52) to the circular trailing edge (53) and are recessed inwardly from a perimeter (22) circumscribed about the rotational axis (20) at the button radius (R) . One of upstream and downstream pressure side portions (24, 26) of the contoured pressure side (58) is straight and another of the upstream and downstream pressure side portions (24, 26) is curved. One of the upstream and downstream suction side portions (28, 30) is straight and another of the upstream and downstream suction side portions (28, 30) is curved. One of the upstream pressure side portion (24) and upstream suction side portion (28) is straight and another of the upstream pressure side portion (24) and upstream suction side portion (28) is curved.
Patent CA-2699713-A1 (CA)
Inventor: BRUCHMANN BERND
IPC: C10G33/04
Filed: 2008-10-02
Abstract: The invention relates to the use of non-dendrimer, hyperbranched polyesters and/or polyester amides, comprising alkyl- and/or alkenyl-substituted succinic acid moieties, as demulsifiers for separating oil-in-water emulsions, especially crude oil emulsions. The invention also relates to non-dendrimer, hyperbranched polyesters or polyester amides, comprising alkyl- and/or alkenyl-substituted succinic acid moieties.
Patent CA-2700158-A1 (CA)
Inventor: MUELLER RUDOLF
IPC: C07D239/88
Filed: 2008-09-19
Abstract: This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin, or where the respiratory depression results form a medical condition such as central sleep apnea, stroke- induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning. In a particular aspect, the invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
Patent CA-2701700-A1 (CA)
Inventor: BASER BELGIN
IPC: E21B33/138
Filed: 2008-10-17
Abstract: A multilayered ball sealer having a deformable layer. The multilayered ball sealer has an outer or intermediate layer that is deformable under pressure. In the former, the deformable layer may be water-soluble or hydrolysable. In the latter, the outer layer is a sheath that contains the deformable layer and adapts to its shape. A multilayered ball sealer may be used as a diversion agent by being suspended in a fluid injected into a wellbore and applying pressure to deform the shape of the intermediate layer such that the multilayered ball sealer adapts to the shape of a perforation opening on which the multilayered ball sealer has seated.
Patent CA-2702865-A1 (CA)
Inventor: GERSTENKORN BERNHARD
IPC: B66B1/46
Filed: 2008-10-27
Abstract: The invention relates to a method for determining a destination call for use of a lift installation (10) with a control unit (50) and at least one destination call device (20).  Several destination calls are ascertained and are made known to the user by means of the destination call device (20). A destination call is selected by a change in position of the user and/or a data communication is activated between the destination call device (20) and a communications unit (40), which is carried by the user, within a defined range (R) of a radio link section of the destination call device (20) and thereupon a destination call is selected by a change in position of the communications unit (40) inside or outside the radio link section. The selected destination call is communicated to the control unit (50) for serving the destination call. The invention further relates to a lift installation (10).
Patent CA-2704012-A1 (CA)
Inventor: WANG YIPING
IPC: B01F25/46
Filed: 2008-11-06
Abstract: Mixing devices and systems are disclosed for storing separate components and for mixing and dispensing those components on demand. A mixing device includes a syringe having a generally tubular housing formed with a mixing chamber. A plunger is fitted to the tubular housing to form a first syringe. A dispensing syringe is releasably connected to the mixing chamber. At this point each syringe holds a desired amount of a mixture component. The contents of one syringe are passed through the mixing chamber to the other syringe, forming a usually incomplete mixture. The mixture is then passed through the mixing chamber to the other syringe. Multiple passes through the mixing chamber are continued until the desired mixing result is achieved, and the mixture material is contained in the second syringe that is used to thereafter dispense desired amounts of the mixture.
Patent CA-2708414-A1 (CA)
Inventor: ASSMANN LUTZ
IPC: A01P7/00
Filed: 2008-11-28
Abstract: The invention relates to active compound combinations, in particular a fungicidal and/or insecticidal composition, comprising Isotianil (3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolecarboxamide) and at least one further insecticide of the anthranil group and optionally one further insecticide of the neonicotinoids. Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi and/or microorganisms and/or pests of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.