baber/WOPTO huggingface dataset:
Patent NZ-576197-A (NZ)
Title: 3 -amino- pyridine derivatives for the treatment of metabolic disorders
Inventor: DEKA NABAJYOTI
IPC: A61K31/4725
Filed: 2007-09-20
Abstract: Disclosed is a compound of general formula (I) e.g. 2,4-Dichloro-N-(5-chloro-6-(isoquinolin-3-yloxy)pyridin-5 3-yl)benzenesulfonamide wherein Ar is a quinoline or isoquinoline moiety; B is -O-, -S-, or -NH-; R1 to R9 are defined in the specification; n is an integer from 1-3; and a pharmaceutically acceptable salt or solvate thereof for treating insulin resistance or hyperglycemia, type 2 diabetes, obesity, glucose intolerance, dyslipidemia, hyperinsulinemia, atherosclerotic disease, polycystic ovary syndrome, coronary artery disease, hypertension, non-alcoholic fatty liver disease or stroke. Also disclosed is a process for the preparation of a compound of general formula (I) which comprises a) reacting a nitrated halopyridine with an aryl amine, alcohol or thiol in presence of a base such as cesium carbonate, to obtain a nitro pyridine compound, subjecting the nitro compound to reduction to obtain a corresponding amino compound; c) reacting the amino compound with one equivalent of sulfonic in the presence of a base to obtain the compound of formula (I),; or reacting the amino compound with two equivalents of sulfonyl at 20 degrees C, in the presence of triethyl amine as a base, to obtain the compound of formula (I); or refluxing the amino compound with an anhydride [(CH2)n(CO)2O] wherein n is as defined above, to obtain an acid of formula (I); or refluxing the amino compound of with a carbonochloridate, in the presence of pyridine or triethyl amine as a base to obtain the compound of formula (I).
Patent NZ-577992-A (NZ)
Title: Assay membrane and method of use thereof
Inventor: KUMBLE SARITA
IPC: G01N33/53
Filed: 2007-10-26
Abstract: Disclosed is a microporous membrane for detecting at least one target analyte in a sample, comprising an array that comprises at least one capture element and six control elements printed on the membrane surface, the at least one capture element corresponding to and being able to bind a target analyte, the six control elements comprising: i) at least two fiduciary markers that permit orientation and gridding of the array, wherein the two fiduciary markers are spatially separated by one or more printed elements, ii) at least one negative control to monitor background signal, iii) at least one negative control to monitor assay specificity, iv) at least one positive colourimetric control, and v) at least one positive control to monitor assay performance.
Patent NZ-579246-A (NZ)
Title: Adhesive patch has an edge that is thinner than the middle with an intermediate area that is thicker than both
Inventor: HARIMA JUN
IPC: A61F13/02
Filed: 2009-08-25
Abstract: An adhesive patch is disclosed. A support layer (21) has an adhesive layer (22) formed upon one surface. The area of the patch is divided into three zones being a peripheral part (3), a central part (1), and an intermediate part (2). The height of the intermediate part (2) is greater than the height of the central part (1) which is higher than the peripheral part (3). This arrangement helps prevent "cold flow" of the adhesive during storage, preventing it from sticking to the wrapper around its edges.
Patent NZ-579382-A (NZ)
Title: Fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents
Inventor: MYHREN FINN
IPC: A61K31/58
Filed: 2008-03-13
Abstract: The disclosure relates to certain unsaturated fatty acid derivatives of therapeutically active glucocorticoides of formula (I) and pharmaceutical formulations containing them, wherein the variables are as defined in the specification. These compounds of formula (I) may be used in the treatment of cancerous and inflammatory diseases including haematological and solid cancers and steroide resistant cancers, asthma as well as steroide resistant inflammations and COPD.
Patent NZ-582667-A (NZ)
Title: Combination of an HMG-CoA reductase inhibitor and a colloidal clay, and method for the preparation thereof
Inventor: KARAVAS EVANGELOS
IPC: A61K9/20
Filed: 2007-06-25
Abstract: Disclosed is a pharmaceutical composition for oral administration comprising Atorvastatin or a pharmaceutical acceptable salt thereof, as an active ingredient, and an effective amount of Attapulgite as a stabilizer to inhibit hydrolysis and/or isomerization and/or elimination and/or oxidation and/or re-, crystallization, wherein said composition is prepared with direct compression and said composition comprises 3% to 10% by weight of said Atorvastatin or salt thereof, wherein said composition does not comprise any buffering or alkaline agent. A process for the preparation of a solid dosage form for oral administration such as a tablet, capsule or sachet containing Atorvastatin, or a pharmaceutical acceptable salt thereof, as an active ingredient and an effective amount of Attapulgite as a stabilizer to inhibit isomerization and/or elimination and/or oxidation and/or re-crystallization wherein is said solid dosage form comprises 3% to 10% by weight of said Atorvastatin or salt thereof is also disclosed, wherein the process comprises the steps of:(a) forming a homogenous mixture by mixing the total quantity of said active ingredient with a portion of the total quantity of Attapulgite and at least one optional excipient such as a binder, a diluent, a disintegrant and/or a glidant and mixing until uniform;(b) sieving the above mixture through a sieve; (c) adding to the sieved mixture the total quantities of at least one optional excipient such as a binder, a diluent, a disintegrant and/or a glidant and mixing until uniform; (d) admixing the remaining portion of the total quantity of Attapulgite and mixing until uniform; (e) subsequently adding a lubricant and forming a homogenous mixture, and (f) formulating the resulting mixture in a solid dosage form either by compressing it into a desired tablet form or by filling capsules or sachets.
Patent NZ-583387-A (NZ)
Title: Container with sealing lid using locking arms and a frame with retaining arms
Inventor: DIPIETRO DEAN
IPC: A47J47/10
Filed: 2009-05-07
Abstract: A releasable resealable container system consisting of a container with a lip around an opening for engaging and sealing with a lid and a lid shaped to engage with the container opening rim. The lid consists of a cover body and a frame, the lid body has at least two locking arms that engage with the container rim to lock the lid in a sealed position, the locking arms are engaged or disengaged by the movement of the frame relative to the lid. The frame has retaining arms operated by a release handle that latch onto the container lip to securely retain the lid assembly. The locking and retaining arms are flexibly hinged to their respective lid components. The lid body contains a gasket to form an interference fit between the lid and the container rim. The container forms a polygonal shape, the locking arms are located to operate on opposite sides of the container, and the retaining arms operate on different container sides to those having locking arms
Patent NZ-586653-A (NZ)
Title: Removal of sulfur compounds from a gas stream utilising a zinc containing sorbent
Inventor: SCHMIDT ROLAND
IPC: B01D50/00
Filed: 2008-10-09
Abstract: Disclosed is an S Zorb type process for removing sulphur compounds such as hydrogen sulphide which comprises: (a) contacting a sulfur-containing gas stream with an initial sorbent in a sorption zone to thereby produce an sulfur-depleted product stream and a sulfur-laden sorbent, wherein said initial sorbent comprises an SZorb Zinc / promoter metal combination; and (b) contacting at least a portion of said sulphur-laden sorbent with a regeneration gas stream in a regeneration zone under regeneration conditions to thereby produce a regenerated sorbent and an off-gas stream, wherein said contacting of step (b) includes introducing said regeneration gas into said regeneration zone at an initial standard gas hourly space velocity (SGHSV) in the range of from about 100 to about 100,000 per hour , wherein said contacting of step (b) includes increasing the SGHSV of said regeneration gas to a final SGHSV that is at least 1,000 per hour higher than said initial SGHSV.
Patent NZ-586690-A (NZ)
Title: Food Waste Digestion System
Inventor: ATKINSON TERRENCE
IPC: B09B3/00
Filed: 2011-07-08
Abstract: A waste digestion system for processing non-liquid organic waste material 6 without the addition of external heat and using thermophilic aerobic bacteria to produce a stable product comprises a primary digester 2 and one or more first subsequent digesters 3. The digesters are configured to contain the waste material. Each digester further includes mixing means configured to mix the contents of that digester with feed air drawn through contents during processing in such a way as to maintain essentially aerobic conditions within the digester. The waste material 6 is first processed in the primary digester 2 before a proportion of the contents of the primary digester 2 are transferred to at least one first subsequent digester 3 where further processing occurs. If the first subsequent digester 3 completes the processing then it will be a final subsequent digester 3. The final contents in each digester will be friable.
Patent NZ-587475-A (NZ)
Title: Bathroom floor with gaps to allow drainage to a waterproof tray on a sub floor
Inventor: POWER PAUL WILFRED
IPC: E04C2/30
Filed: 2010-08-20
Abstract: A wet area which includes a floor consisting of a substantially flat visible floor 4 supported above a subfloor 3, the visible floor 4 being formed with drainage gaps 6 to allow drainage of water through the visible floor 4 onto the subfloor 3. The subfloor 3 includes a waterproof tray having sides at least equal in height to the distance between the base 7 of the tray and the upper surface of the visible floor, and a base which slopes towards a drain 10. The visible floor 4 is supported by a plurality of spaced supports 14 placed on the subfloor 3. Each support's height is adjustable.
Patent NZ-588799-A (NZ)
Title: Inhibitors of iap
Inventor: COHEN FREDERICK
IPC: A61K38/06
Filed: 2005-07-05
Abstract: Disclosed are heterocyclic amide derivatives of proline peptides, as represented by the general formula (I), wherein: X1, X2 and X3 are independently O or S; Y is (CHR7)n, O or S; wherein n is 1 or 2 and R7 is H, halogen, alkyl, aryl, aralkyl, amino, arylamino, alkylamino, aralkylamino, alkoxy, aryloxy or aralkyloxy; A is an optionally substituted 5-membered heterocycle; R1 is H or R1 and R2 together form a 5-8 member ring; R2 is alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, a heterocycle or heterocyclylalkyl, each optionally substituted with hydroxyl, mercapto, halogen, amino, carboxyl, alkyl, haloalkyl, alkoxy or alkylthio; R3 is H or alkyl; R4 and R4' are independently H, hydroxyl, amino, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, or heteroarylalkyl wherein each alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl and heteroarylalkyl is optionally substituted; R5 and R5' are each independently H or alkyl; R6 and R6' are each independently H, alkyl, aryl or aralkyl; and salts and solvates thereof. Further disclosed is a pharmaceutical composition which comprises a compound as defined above and a carrier, diluent or excipient for the treatment of cancer and / or for inducing apoptosis in a cell.
Patent NZ-590315-A (NZ)
Title: Fxa inhibitors with cyclic amidoxime or cyclic amidrazone as p4 subunit, processes for their preparations, and pharmaceutical compositions and derivatives thereof
Inventor: SONG HO YOUNG
IPC: C07D413/12
Filed: 2009-06-05
Abstract: Disclosed is a thiophene amide substituted oxazolidinone derivative with cyclic amidoxime or cyclic amidrazone group represented by formula 1, prodrug, hydrate, solvate, isomer or pharmaceutically acceptable salt thereof. Also disclosed is a pharmaceutical anticoagulant composition comprising a compound of formula (I). Further disclosed is the use of an oxazolidinone in the manufacture of a medicament for preventing or treating thrombosis, myocardial infarction, arteriosclerosis, inflammation, stroke, angina pectoris, restenosis, intermittent claudication, phlebothrombosis, pulmonary embolism, arterial thrombosis, myocardial ischemia, thromboembolism, artery disease, cerebral artery disease or peripheral artery disease.
Patent NZ-591629-A (NZ)
Title: Die,system, and method for coextruding a plurality of fluid layers using forming stems and distribution plates
Inventor: ROBERTS LAWRENCE E
IPC: B29C48/49
Filed: 2009-09-15
Abstract: 591629 Disclosed is a die for coextruding a plurality of fluid layers for extruding layered plastic polymers. The die comprises a primary forming stem and one or more distribution plates, each of the plates having a fluid inlet and a fluid outlet where the fluid outlet from each of the plates is in fluid communication with the primary forming stem and structured to deposit a layer of fluid onto the primary forming stem. The die also comprises a microlayer assembly, comprising a microlayer forming stem, and a plurality of microlayer distribution plates, each of the microlayer plates having a fluid inlet and a fluid outlet, with the fluid outlet from each of the microlayer plates being in fluid communication with the microlayer forming stem and structured to deposit a microlayer of fluid onto the microlayer forming stem. The microlayer plates are arranged to provide a predetermined order in which the microlayers are deposited onto the microlayer forming stem to form a substantially unified, microlayered fluid mass on the microlayer forming stem. The microlayer forming stem is in fluid communication with the primary forming stem such that the microlayered fluid mass flows from the microlayer forming stem and onto the primary forming stem. The distribution plates have a thickness ranging from about 0.5 to about 2 inches and the microlayer distribution plates have a thickness ranging from about 0.1 to about 0.5 inch.
Patent NZ-592554-A (NZ)
Title: Synthesis and novel salt forms of (r)-5-((e)-2-(pyrrolidin-3-ylvinyl)pyrimidine
Inventor: AKIREDDY SRINIVISA RAO
IPC: A61K31/505
Filed: 2009-11-30
Abstract: Abstract 592554 The present disclosure relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine crystalline salt forms, and novel polymorphic forms of these salts.the crystalline acid addition salts of the disclosure include salts wherein the acid is selected from hydrochloric, sulfuric, methanesulfonic, maleic, phosphoric, I-hydroxy-2-naphthoic, ketoglutaric, malonic, L-tartaric, fumaric, citric, L-malic, hippuric, L-lactic, benzoic, succinic, adipic, acetic, nicotinic, propionic, orotic, 4-hydroxybenzoic, di-p-toluoyl-D-tartaric, di-panisoyl- D-tartaric, di-benzoyl-D-tartaric, 10-camphorsulfonic, camphoric, and phencyphos.
Patent NZ-592968-A (NZ)
Title: Azaindoles substituted with either triazine or pyrimidine useful as inhibitors of janus kinases consisting of JAK1, JAK2, JAK3, and TYK2
Inventor: FARMER LUC
IPC: A61K31/53
Filed: 2007-01-17
Abstract: Disclosed are compounds of formula (I) and methods for their preparation. The compounds have an azaindole core and are substituted with either a pyrimidine or triazine moiety. Additionally, R1 is NR-CR2-C(O)-NR2 X is N or CR The compounds of formula (I) are useful as inhibitors of Janus kinases, a family of tyrosine kinases consisting of JAK1, JAK2, JAK3 and TYK2. The compounds are therefore useful as pharmaceuticals for treating a disease or condition such as a proliferative disorder, a cardiac disorder, a neurodegenerative disorder, an autoimmune disorder, a condition associated with organ transplantation, an inflammatory disorder, or an immunologically mediated disorder. In particular the pharmaceuticals are useful for treating asthma, transplant rejection and rheumatoid arthritis.
Patent NZ-595852-A (NZ)
Title: Stable pharmaceutical composition comprising ethyl eicosapentaenoate
Inventor: MANKU MEHAR
IPC: A61K31/20
Filed: 2010-04-29
Abstract: Disclosed is a pharmaceutical composition comprising at least 95%, by weight of all fatty acids present, ethyl eicosapentaenoate (ethyl-EPA) and a capsule shell comprising at least one plasticizer comprising a hygroscopic plasticizer and a film-forming material which does not include chemically modified gelatin, wherein the composition has a baseline peroxide value not greater than 5 meq/kg and upon storage of the composition at 25 °C and 60% RH for a period of 6 months, the composition has a second peroxide value not greater than 8 meq/kg, wherein the hygroscopic plasticizer comprises glycerol and the film-forming material comprises gelatin, and wherein the capsule shell has a weight ratio of gelatin to glycerol of about 2.5:1 to about 10:1.
Patent NZ-601272-A (NZ)
Title: Water-based resin composition and articles made therefrom
Inventor: WANG SHIPING
IPC: C08J3/20
Filed: 2009-03-13
Abstract: 601272 Disclosed is an aqueous elastomer dispersion, comprising: a dispersed phase comprising an elastomer and an additional polymer selected from the group consisting of a liquid polyisoprene, a polyisoprene with a molecular weight of between about 20,000-100,000, an isomer or analogue of polyisoprene, a terminal-functionalized derivative of polyisoprene, a copolymer of polyisoprene, polychloroprene, a styrene-butadiene copolymer, acrylonitrile butadiene copolymers, styrene block copolymers, butyl rubber, and modified forms of these polymers, wherein said dispersed phase is formed by dissolving the elastomer and additional polymer in a solvent system; and an aqueous phase, wherein the aqueous elastomer dispersion has a total solids content of from about 45% to about 70%. Also disclosed is an article made from the dispersion, a method of preparing the dispersion and a compounded latex comprising the dispersion.
Patent NZ-629283-A (NZ)
Title: Novel binding molecules with antitumoral activity
Inventor: BRACK SIMON
IPC: C07K16/32
Filed: 2013-03-08
Abstract: Disclosed is a binding molecule that specifically binds to two different epitopes of an antigen expressed on tumour cells, wherein the binding molecule comprises: (a) a first binding (poly)peptide that specifically binds to a first epitope of said antigen expressed on tumour cells, wherein said first binding (poly)peptide is a Fyn SH3-derived polypeptide; and (b) a second binding (poly)peptide that specifically binds to a second epitope of said antigen expressed on tumour cells, wherein the antigen expressed on tumour cells is selected from the group consisting of HER2, HER1, HER3, HER4, receptors of the insulin, PDGF, FGF, VEGF, HGF, Trk, Eph, AXL, LTK, TIE, ROR, RET, KLG, RYK, MuSK families, EpCAM, CD20, CD33, CD52 and CD30.
Patent NZ-705599-A (NZ)
Title: Flow regulating applied magnetic envelope
Inventor: CABOT DOUGLAS C
IPC: F16L55/1645
Filed: 2011-06-22
Abstract: Bridging and obstructing materials such as ragged bodies of ferromagnetic materials from cartridges 125 are introduced into the flow system of a superstructure by a pump 145 through a connection point 140 upstream of a targeted point (not shown) on the superstructure 130 to which a magnetic envelope (not shown) is applied. The bridging and obstructing materials are captured into a framework by the applied magnetic envelope adjacent the targeted point so that the framework regulates the flow, including possibly blocking the flow altogether. The method is useful to regulate flows of oil or gas at wellheads, blowout preventers, or other, in particular underwater, superstructure associated with oil or gas flow.
Patent NZ-714946-A (NZ)
Title: Mattress for evenly gathering and dispersing human body gravity
Inventor: ZHANG SHAOHUA
IPC: A47C27/08
Filed: 2014-05-20
Abstract: A mattress for evenly gathering and dispersing human body gravity comprises elastic surface layer connecting cloth (1), elastic support frames (2), lateral connecting cloth (3), a filling region (4), granular fillers (5), a filler inlet/outlet (6), lower connecting cloth (7), a foot limiting belt (8), a leg limiting belt (9), hip limiting belts (10) and a back limiting belt (11) (“limiting belts” for short). The width of each of the limiting belts (8, 9, 10, 11) is less than that of the filling region. Upper ends and lower ends of the limiting belts (8, 9, 10, 11) are separately connected to an upper cloth layer and a lower cloth layer.
Patent NZ-721040-A (NZ)
Title: Fluid transmission coupling with independent member pressure relieving cam
Inventor: GATTI GIANMARCO
IPC: F16L37/23
Filed: 2014-11-10
Abstract: Fittings which may be rapidly coupled to one another to connect a fluid feed, by means of rigid pipes or flexible hoses, are frequently required for fluid transmission for example in operating machines and hydraulic equipment. The currently marketed fluid transmission solutions show that the coupling between the male coupler and the female coupler is not always very easy with effort increasing incrementally as the residual pressure present in the circuit increases. There is provided a fluid transmission coupling assembly having a hydraulic feeding block, at least two female couplers inserted in a hydraulic feeding block, and at least two male couplers adapted to be coupled with the at least two female couplers, respectively, the block including at least two hydraulic lines and at least one draining line, and a lever integral with a cam adapted to relieve the pressure from a chamber inside each female coupler and adapted to uncouple the male coupler from the female coupler, each female coupler comprising a pressure relief valve which puts said chamber into communication with the draining line, the cam comprising a first member, which acts on the female coupler of a first of the at least two hydraulic lines, and a second member, which acts on the female coupler of a second of the at least two hydraulic lines, wherein the first and the second member are independently and selectively movable between an operating position on the first hydraulic line and on the second hydraulic line, respectively, by the lever adapted to be rotated in opposite directions, the first and the second member have a first and a second disc-shaped attachment portion with a first and a second loop, respectively, the attachment portions are associated with a central shaft controlled by rotation of the lever, the central shaft is adapted to be selectively moved in opposite directions into a respective loop selectively engaging a respective attachment portion.
Patent NZ-723331-A (NZ)
Title: Means and methods for producing stable antibodies
Inventor: KWAKKENBOS MARK JEROEN
IPC: C12N5/0781
Filed: 2015-01-30
Abstract: The present invention provides methods for obtaining, from an ex vivo B cell culture, B cells that are capable of producing antibodies with a higher stability and with the same or a lower binding affinity, as compared to an initial parent antibody. These B cells are obtained by selecting B cells with a higher binding avidity than the average binding avidity of the ex vivo B cell culture. Antibodies produced by these high avidity B cells are tested in order to determine their affinity and their thermal stability and/or their resistance to aggregation and/or their chemical stability.
Patent NZ-730032-A (NZ)
Title: Flame simulating assembly
Inventor: MICHAEL JACH
IPC: H05B1/00
Filed: 2017-03-13
Abstract: A flame simulating assembly including a light source, a screen having a translucent region which subjects light from the light source transmitted therethrough to diffusion and a transparent region, and a flicker element for intermittently reflecting the light from the light source toward the screen, to provide images of flames in a predetermined portion thereof. The screen includes a fringe region positioned between the translucent region and the transparent region. The fringe region includes a number of round or oblong diffusing areas for diffusing the light from the light source and a number of transparent areas positioned between the diffusing areas. The diffusing areas provide partial images of flames in the fringe region so that gaps are observed between the upper parts of the images of flames.