Patent SG-11201900545T-A (SG)
Title: Pharmaceutical compounds
Inventor: HEWITT PETER
IPC: C07D491/10
Filed: 2017-07-26
Abstract: International Patent Classification: CO7D 401/14 (2006.01) CO7D 405/14 (2006.01) CO7D 413/14 (2006.01) A61K 31/4412 (2006.01) A61K 31/4427 (2006.01) A61K 31/513 (2006.01) CO7D 401/04 (2006.01) A61P 19/00 (2006.01) CO7D 409/14 (2006.01) A61P 25/16 (2006.01) CO7D 491/10 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/GB2017/052178 (22) International Filing Date: 26 July 2017 (26.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1612938.9 26 July 2016 (26.07.2016) GB (71) Applicant: ALMAC DISCOVERY LIMITED [GB/GB]; Almac House, 20 Seagoe Industrial Estate, Craigavon BT63 5QD (GB). (72) Inventors: HEWITT, Peter; c/o Almac Discovery, Almac House, 20 Seagoe Industrial Estate, Craigavon BT63 5QD USPs ucHs OTUs JAMMs & Jose p /tins > DUB Panel 0 I Rl ) N \-- R . R5 X O (I) W O 20 18/0 20 242 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 February 2018 (01.02.2018) WIP0 I PCT ill~~~~~~~~ 011101010VIIIOH olo omoitiloit Imo ow (10) International Publication Number WO 2018/020242 Al (GB). MCFARLAND, Mary Melissa; c/o Almac Discov- ery, Almac House, 20 Seagoe Industrial Estate, Craigavon BT63 5QD (GB). ROUNTREE, James Samuel Shane; c/o Almac Discovery, Almac House, 20 Seagoe Industrial House, Craigavon BT63 5QD (GB). BURKAMP, Frank; c/o Almac Discovery, Almac House, 20 Seagoe Industrial Estate, Craigavon BT63 5QD (GB). BELL, Christina; c/o Almac Discovery, Almac House, 20 Seagoe Industrial Es- tate, Craigavon BT63 5QD (GB). PROCTOR, Lauren; c/o Almac Discovery, Almac House, 20 Seagoe Industrial Es- tate, Craigavon BT63 5QD (GB). HELM, Matthew Dun- can; c/o Almac Discovery, Almac House, 20 Seagoe Indus- trial Estate, Craigavon BT63 5QD (GB). O'DOWD, Conn; c/o Almac Discovery, Almac House, 20 Seagoe Industrial Estate, Craigavon BT63 5QD (GB). HARRISON, Timo- thy; c/o Almac Discovery, Almac House, 20 Seagoe Indus- trial Estate, Craigavon BT63 5QD (GB). (74) Agent: BOULT WADE TENNANT; Verulam Gardens, 70 Gray's Inn Road, London WC1X 8BT (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (54) Title: PHARMACEUTICAL COMPOUNDS (57) : The present invention relates to compounds of Formula (I) that are useful as inhibitors of the activity of the ubiquitin specific protease USP19. The present invention also relates to pharmaceutical compositions comprising these compounds and to meth- ods of using these compounds in therapy. [Continued on next page] WO 2018/020242 Al IMEDIMOM0101011M1E10011010101MOIE0IIMEMOIMIE DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))