Patent SG-11201808724S-A (SG)
Title: Anti-tim-3 antibodies and compositions
Inventor: LINDSTED TRINE
IPC: C07K16/28
Filed: 2017-04-11
Abstract: Ar [15086.15086] IgG1 • o• [15086.16837] IgG1 LALA 800- •c• [15086.17144] IgG4 • lEl• [15086.17145] IgG2 Control mAb 400- 0 0.0001 0.001 0.01 0.1 1 10 Antibody concentration [pg/m1] W O 20 1717 / 8 493 Al TD L- FD 0 600- Li_ a ) c a) u) 200- c 100 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/178493 Al 19 October 2017 (19.10.2017) WIPO I PCT (51) International Patent Classification: C07K 16/28 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/EP2017/058696 (22) International Filing Date: 11 April 2017 (11.04.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/321,476 12 April 2016 (12.04.2016) US (71) Applicant: SYMPHOGEN A/S [DK/DK]; Pederstrupvej 93, 2750 Ballerup (DK). (72) Inventors: LINDSTED, Trine; Hyldevwnget 13, 3520 Farum (DK). GJETTING, Torben; Vibevej 7, 4040 Jyllinge (DK). GALLER, Gunther Roland; Solsikkevej 17, 4040 Jyllinge (DK). GAD, Monika; Gravenstensvej 8, 3450 Alleroed (DK). GRANDAL, Michael Monrad; Sol- brinken 26a, 2750 Ballerup (DK). KOEFOED, Klaus; Havneholmen 24, 1. tv, 1561 Copenhagen V (DK). KRAGH, Michael; Laessoeesgade 1A, 5. Tv., 2200 Copenhagen N (DK). HORAK, Ivan David; 21 Cliff Street, West Orange, New Jersey 07052 (US). BOUQUIN, Thomas; Kirkeltevej 44, 3450 Alleroed (DK). PEDER- SEN, Mikkel Wandahl; Forelvej 17, 3450 Alleroed (DK). (74) Agent: POHLMAN, Sandra; TheatinerstraBe 16, 80333 Miinchen (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, [Continued on next page] (54) Title: ANTI-TIM-3 ANTIBODIES AND COMPOSITIONS 1111111111111101110111111111110101111101110101111111101111111111011111111111110111111 Figure 1 (57) : This invention relates to anti-TIM-3 antibodies and antibody compositions and their use in enhancing immunity in a patient, e.g., to treat can- cer. WO 2017/178493 Al MIDEDIMOM0101011101010MOINIERRIMOMOVOIS SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))