Patent SG-11201808458Q-A (SG)
Title: Compositions and methods for stabilizing alphaviruses with improved formulations
Inventor: LIVENGOOD JILL ANN
IPC: A61K47/26
Filed: 2017-03-27
Abstract: 00E+02 1.00E+01 1.00E+00 1 W O 20 1717 / 26 43 Al m 1.00E+03 a 3 4 5 Formulation FIG. 1 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/172643 Al 5 October 2017 (05.10.2017) WIPO I PCT 11111111111111011101111111111101011111011101011101111111111111011111111111110111111 Loss upon lyophilization 0 Liquid 0 Week 0 (51) International Patent Classification: 9618 3 9 / 1 2 (2006.01) A61K 47/26 (2006.01) A61K 47/22 (2006.01) 961% 39/00 (2006.01) (21) International Application Number: PCT/US2017/024365 (22) International Filing Date: 27 March 2017 (27.03.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/316,262 31 March 2016 (31.03.2016) US (71) Applicant: TAKEDA VACCINES, INC. [US/US]; One Takeda Parkway, Deerfield, Illinois 60015 (US). (72) Inventors: LIVENGOOD, Jill Ann; 2348 Hampshire Court, Fort Collins, Colorado 80526 (US). POWELL, Timothy, Duane; 3105 Sail Place, Fort Collins, Colorado 80525 (US). (74) Agents: HANSON, Roberta et al.; 2200 Wells Fargo Cen- ter, 90 South Seventh St., Minneapolis, Minnesota 55402- 3901 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, [Continued on next page] (54) Title: COMPOSITIONS AND METHODS FOR STABILIZING ALPHAVIRUSES WITH IMPROVED FORMULATIONS (57) : Embodiments herein relate to com- positions and methods for stabilizing live alphavir- uses. Other embodiments relate to compositions and methods for reducing degradation of live, attenuated 1 00E+06 alphaviruses. Certain embodiments relate to provid- ing a stabilizing composition while reducing im- mune reaction in a subject to excipients that stabil- 1.00E+05 , ize the live alphaviruses by providing improved for- mulations. Yet other embodiments relate to uses of compositions disclosed herein in kits for portable 1.00E+04 - applications and methods wherein the compositions reduce degradation of the live alphaviruses. WO 2017/172643 Al 1#11101MOMOIDEIROIDEOMOIDE1011100111100MOVOIMIE SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Published: GW, KM, ML, MR, NE, SN, TD, TG). — with international search report (Art. 21(3))