Patent EA-003463-B1 (EA)
Title: Method and composition for the treatment of epidermal irritations and infections
IPC: A61P31/22
Filed: 1999-06-09
Abstract: 1. A composition comprising stannous fluoride (+2) and zinc gluconate. 2. The composition according to claim 1 further comprising an additional zinc salt. 3. The composition according to claim 2 wherein the zinc salt is selected from the group consisting of zinc chloride, zinc sulfate, zinc phosphate, zinc oxide, zinc pyrophosphate and zinc thiocyanate. 4. The composition according to claim 2 wherein the additional zinc salt is zinc chloride. 5. The composition according to claim 1 comprising stannous fluoride (+2) and zinc gluconate in a non-aqueous medium. 6. The composition according to claim 1 further comprising at least one amino acid. 7. The composition according to claim 6 wherein the amino acid is an essential or non-essential L- or D- amino acid selected from the group consisting of lysine, arginine, histidine, phenylalanine, threonine, leucine, isoluceine, cysteine, methionine, valine, alanine, glycine, proline, glutamine, serine, tryptophan, tyrosine, and asparagine. 8. The composition according to claim 1 wherein the stannous fluoride (+2) is present in an amount of from about 0.01 % to about 10.0 % by weight. 9. The composition according to claim 1 wherein the zinc gluconate is present in an amount of from about 0.05 % to about 10.0 % by weight. 10. The composition according to claim 2 wherein said additional zinc salt is in an amount from about 0.05 % to about 10.0 % by weight. 11. The composition according to claim 6 wherein the amino acid is present in an amount of from about 0.05 % to about 50.0 % by weight. 12. The composition according to claim 6 wherein the amino acid is L-lysine. 13. The composition according to claim 1 comprising: Stannous fluoride (+2) 0.20 % by wt; Zinc gluconate 1.50 % by wt; and Glycerin 98.30 % by wt. 14. The composition according to claim 2 comprising: Stannous fluoride (+2) 0.20 % by wt; Zinc gluconate 7,.50 % by wt; Zinc chloride 0.50 % by wt; Glycerin 85.50 % by wt; and Carbopol 7.30 % by wt. 15. The composition according to claim 2 comprising: Stannous fluoride (+2) 0.20 % by wt; Zinc gluconate 1.50 % by wt; Zinc chloride 0.50 % by wt; L-Lysine 10.00 % by wt; Glycerine 60.00 % by wt; Carbopol 2.00 % by wt; and Distilled Water 24.80 % by wt. 16. A method of treating an epidermal irritation or infection comprising administering an effective amount of a composition comprising stannous fluoride (+2) and at least one zinc containing compound to an animal in need thereof. 17. The method according to claim 16 wherein the infection is a viral, bacterial, parasitic or fungal infection. 18. The method according to claim 17 wherein the viral infection is a herpes infection. 19. The method according to claim 17 wherein the viral infection is a papilloma virus infection. 20. The method according to claim 17 wherein the fungal infection is caused by Microsporum or Trichophyton. 21. The method according to claim 17 wherein the bacterial infection is a Staphylococcus, Streptococcus or Dermatophilis bacterial infection. 22. The method according to claim 16 wherein the epidermal irritation is a burn. 23. The method according to claim 17 wherein the animal is a human. 24. The method according to claim 17 wherein the animal is a horse, cat or dog. 25. The method according to claim 16 wherein the zinc containing compound is a zinc carboxylate. 26. The method according to claim 25 wherein the zinc carboxylate is selected from the group consisting of zinc gluconate, zinc tartrate, zinc malate, zinc citrate and zinc acetate. 27. The method according to claim 25 wherein the zinc carboxylate is zinc gluconate. 28, The method according to claim 27 wherein the composition further comprises an additional zinc salt. 29. The method according to claim 28 wherein the additional zinc salt is selected from the group consisting of zinc chloride, zinc sulfate, zinc phosphate, zinc oxide, zinc pyrophosphate and zinc thiocyanate. 30. The method according to claim 28 wherein the additional zinc salt is zinc chloride. 31. The method according to claim 16 wherein the composition comprises stannous fluoride (+2) and zinc gluconate in a non-aqueous medium. 32. The method according to claim 16 wherein the composition further comprises at least one amino acid. 33. The method according to claim 32 wherein the amino acid is an essential or non-essential L- or D- amino acid selected from the group consisting of lysine, arginine, histidine, phenylalanine, threonine, leucine, isoluceine, cysteine, methionine, valine, alanine, glycine, proline, glutamine, serine, tryptophan, tyrosine, and asparagine. 34. The method according to claim 16 wherein the stannous fluoride is present in an amount ranging from about 0.01 % to about 10.0 % by weight. 35. The method according to claim 27 wherein the zinc gluconate is present in an amount ranging from about 0.05 % to about 10.0 % by weight. 36. The method according to claim 28 wherein the additional zinc salt is present in an amount ranging from about 0.05 % to about 10.0 % by weight. 37. The method according to claim 32 wherein the amino acid is present in an amount of from about 0.05 % to about 50.0 % by weight. 38. The method according to claim 32 wherein the amino acid is L-lysine. 39. The method according to claim 27 wherein the composition comprises: Stannous fluoride (+2) 0.20 % by wt; Zinc gluconate 1.50 % by wt; and Glycerin 98.30 % by wt. 40. The method according to claim 28 wherein the composition comprises: Stannous fluoride (+2) 0.20 % by wt; Zinc gluconate 1.50 % by wt; Zinc chloride 0.50 % by wt; Glycerin 85.50 % by wt; and Carbopol 7.30 % by wt. 41. The method according to claim 28 wherein the composition comprises: Stannous fluoride (+2) 0.20 % by wt; Zinc gluconate 1.50 % by wt; Zinc c chloride 0.50 % by wt; L-lysine 10.04 % by wt; Glycerine 60.00 % by wt; Carbopol 2.00 % by wt; and Distilled Water 24.80 % by wt. 42. A composition for treating an epidermal irritation or infection in an animal comprising water, stannous fluoride and zinc gluconate, wherein said zinc gluconate is present in an amount sufficient to prevent oxidation and hydrolysis of the stannous ion for at least three months. 43. A composition according to claim 42, further comprising an additional zinc salt. 44. A composition according to claim 43, wherein the zinc salt is selected from the group consisting of zinc chloride, zinc sulfate, zinc phosphate, zinc oxide, zinc pyrophosphate and zinc thiocyanate. 45. A composition according to claim 44, wherein the additional zinc salt is zinc chloride. 46. A composition according to claim 42, further comprising at least one amino acid. 47. A composition according to claim 46, wherein the amino acid is an essential or non-essential L- or D- amino acid selected from the group consisting of lysine, arginine, histidine, phenylalanine, threonine, leucine, isoluceine, cysteine, methionine, valine, alanine, glycine, proline, glubamine, serine, tryptophan, tyrosine, and asparagine. 48. A composition according to claim 42, wherein the stannous fluoride is present in an amount of from about 0.01% to about 10.0% by weight. 49. A composition according to claim 42, wherein the zinc gluconate is present in an amount of from about 0.05% to about 10.0% by weight. 50. A composition according to claim 43, wherein said additional zinc salt is in an amount from about 0.05% to about 10.0% by weight. 51. A composition according to claim 46, wherein the amino acid is present in an amount of from about 0.05% to about 50.0% by weight. 52. A composition according to claim 46, wherein the amino acid is L-lysine. 53. A composition for treating an epidermal irritation or infection in an animal comprising comprising stannoue fluoride, zinc gluconate and glycerin, and optionally at least one member selected from the group consisting of an amino acid, an additional zinc salt, and a hydrogal forming agent. 54. A composition according to claim 53 comprising: Stannous fluoride (+2) 0.20 % by wt; Zinc gluconate 1.50 % by wt; and Glycerin 98.30 % by wt. 55. A composition according to claim 53 comprising: Stannous fluoride (+2) 0.20 % by wt; Zinc gluconate 1.50 % by wt; Zinc chloride 0.50 % by wt; Glycerin 85.50 % by wt; and Carbopol 7.30 % by wt. 56. A composition according to claim 53 comprising: Stannous fluoride (+2) 0.20 % by wt; Zinc gluconate 1.50 % by wt; Zinc c chloride 0.50 % by wt; L-lysine 10.04 % by wt; Glycerine 60.00 % by wt; Carbopol 2.00 % by wt; and Distilled Water 24.80 % by wt. 57. A method according to claim 27 wherein said zinc gluconate is present in an amount sufficient to prevent oxidation and hydrolysis of the stannous ion for at least three months. 58. The method according to claim 57, wherein the infection is a viral, bacterial, parasitic or fungal infection. 59. The method according to claim 58 wherein the viral infection is a herpes infection. 60. The method according to claim 58 wherein the viral infection is a papilloma virus infection. 61. The method according to claim 58 wherein the fungal infection is caused by Microsporum or Trichophyton. 62. The method according to claim 58 wherein the bacterial infection is a Staphylococcus, Streptococcus or Dermatophilis bacterial infection. 63. The method according to claim 57 wherein the animal is a human. 64. The method according to claim 57 wherein the animal is a horse, cat or dog. 65. A method according to claim 28 wherein said zinc gluconate is present in an amount sufficient to prevent oxidation and hydrolysis of the stannous ion for at least three months.