Patent SG-11201811416V-A (SG)
Title: Crystalline solid forms of a bet inhibitor
Inventor: CHEN SHILI
IPC: C07D471/02
Filed: 2017-06-19
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111411 0 11101 HOE 010 1111 1 0 01 OH OH OH MO HO 1111 11110 MAMIE International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2017/222977 Al 28 December 2017 (28.12.2017) WIP0 I PCT (51) International Patent Classification: C07D 471/02 (2006.01) SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (21) International Application Number: PCT/US2017/038121 (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (22) International Filing Date: 19 June 2017 (19.06.2017) GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (25) Filing Language: English EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (26) Publication Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (30) Priority Data: KM, ML, MR, NE, SN, TD, TG). 62/352,220 20 June 2016 (20.06.2016) US 62/397,575 21 September 2016 (21.09.2016) US Published: (71) Applicant: INCYTE CORPORATION [US/US]; 1801 — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the Augustine Cut-Off, Wilmington, Delaware 19803 (US). claims and to be republished in the event of receipt of (72) Inventors: CHEN, Shili; Incyte Corporation, 1801 Au- gustine Cut-Off, Wilmington, Delaware 19803 (US). JIA, Zhongjiang; Incyte Corporation, 1801 Augustine Cut- amendments (Rule 48.2(h)) Off, Wilmington, Delaware 19803 (US). LIU, Pingli; In- cyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803 (US). QIAO, Lei; Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803 = (US). WU, Yongzhong; Incyte Corporation, 1801 Augus- tine Cut-Off, Wilmington, Delaware 19803 (US). ZHOU, Jiacheng; Incyte Corporation, 1801 Augustine Cut-Off, Wilmington, Delaware 19803 (US). LI, Qun; Incyte Cor- poration, 1801 Augustine Cut-Off, Wilmington, Delaware =_ = 19803 (US). (74) Agent: KING, Annie J. et al.; Fish & Richardson P.C., P.O. = Box 1022, Minneapolis, Minnesota 55440-1022 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, = (81) = = = = = = = — = = _ (54) Title: CRYSTALLINE SOLID FORMS OF A BET INHIBITOR Il IN I °N, C) (57) : The present application relates to crystalline solid forms of an inhibitor of BET proteins S.:\" such as BRD2, BRD3, BRD4, and BRD-t, including methods of preparation thereof, and intermediates IN ei o 10 1 \ in the preparation thereof, where the compound is useful in the treatment of diseases such as cancer. el el IN \ N ..-• N H 11 0 © N Compound I C