Patent SG-11201811788S-A (SG)
Title: Antibodies with low immunogenicity and uses thereof
Inventor: JOHNSON JEFFREY
IPC: C07K16/00
Filed: 2017-07-05
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD Organization HIM 011101011M 01 110100111011101 MOM INOUE ill OEN International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/009499 Al 11 January 2018 (11.01.2018) W I POI PCT (51) International Patent Classification: (74) Agent: GEORGE, Nikolaos, C. et al.; Jones Day, 250 C07K 16/00 (2006.01) CO7K 16/18 (2006.01) Vesey Street, New York, NY 10281-1047 (US). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/US2017/040653 kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 05 July 2017 (05.07.2017) CA, DZ, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (26) Publication Language: English KR, MG, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (30) Priority Data: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 62/359,150 06 July 2016 (06.07.2016) US SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: CELGENE CORPORATION [US/US]; 86 Morris Avenue, Summit, NJ 07901 (US). (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (72) Inventors: JOHNSON, Jeffrey; 5402 Foxtail Loop, Carls- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, bad, CA 92010 (US). DEARTH, Lawrence; 602 Shanas UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Lane, Encinitas, CA 92024 (US). HADJIVASSILIOU, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Bellos; 12791 Calle de la Siena, San Diego, CA 92130 (US). EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, — SUN, Jeonghoon; 4992 35th Street, San Diego, CA 92116 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (US). HARIHARAN, Hari; 6575 Little McGonigle Ranch TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Road, San Diego, CA 92130 (US). KM, ML, MR, NE, SN, TD, TG). = = = (54) Title: ANTIBODIES WITH LOW IMMUNOGENICITY AND USES THEREOF = anti-CD47 Deimmun-2 CCRF-CEM binding et saturation (-1 OugirtIL ) = 200 00 = 150000 = C = — 13 3 10U Oti — Low 816 co — = = es -0,5 $' = 50000 = = n ° 21 r. 17 'j, c i l a i 7- P.'PrilS@P (Nr3 8 Vc'o - - CI 2 (r) CO et) r3 to oo CO = oo el (9 (9 (0 0 71- 2 - - - _, - - - m _, - . ... - - . _u r i (204 0 hC< Q'Ii\" Ln to & 1‹. && 1«.< c:7 Lo 1— u s C x HC iv CT © © ---.... Fi g ure 1 ,-1 (57) : Provided herein are antibodies and antigen-binding fragments thereof with low or no immunogenicity in humans and 0 optionally with desirable manufacturing properties. Also provided are compositions comprising such antibodies or antigen-binding ei fragments, methods of using such antibodies, and methods for making such antibodies. [Continued on next page] WO 2018/009499 Al MIDEDIMOMOIDEIREIERIEMBEHOMEMOIMIE Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt amendments (Rule 48.2(h)) of — with sequence listing part of description (Rule 5.2(a))