baber/WOPTO huggingface dataset:
Patent NZ-521701-A (NZ)
Title: Anthranyl amides and their use as medicaments
Inventor: KRUGER MARTIN
IPC: A61P19/02
Filed: 2001-05-07
Abstract: Disclosed are compounds of formula I, wherein: A is =NR7, W is O, Z is a bond, R1 is optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, or NR12R13, X is alkyl, R2 is optionally substituted cycloalkyl, cycloalkene, alicyclic ketone or non-aromatic heterocyclic, D is N or C-R3, E is C-R4, F is C-R5, G is C-R6, and R9 is H or alkyl. Also disclosed are intermediates for the production of compounds of formula I. The compounds of formula I are used in the manufacture of medicaments for the treatment of diseases that are triggered by persistent angiogenesis.
Patent NZ-523467-A (NZ)
Title: Improved dielectric heating using inductive coupling
Inventor: BLAKER GLENN CRAIG
IPC: H05H1/46
Filed: 2001-06-21
Abstract: A method and apparatus for heating or drying material by applying radio frequency (RF) power to a material in a resonant cavity; wherein an RF power source is inductively coupled to a resonant cavity formed by distributed inductance in resonance with the applicator and material where the magnetic field established by the feed line(s) induces a voltage on the applicator permitting feed line voltages delivering said RF power to the cavity to be lower than those that would normally be encountered for equivalent RF heating using direct coupling.
Patent NZ-527749-A (NZ)
Title: Protein, which the property of binding human GHRH obtained from the plant Pilocarpus heterophy/lus, of molecular mass 90.9 kDa and able to be presented in a glycosylated or non glycosylated form
Inventor: FERRANDIS ERIC
IPC: C07K16/16
Filed: 2002-02-26
Abstract: A human GHRH-binding protein (human growth hormone releasing hormone) is described. The protein, which is obtained from the Pilocarpus Heterophyllus plant, can be used to prepare medicaments intended to antagonise the effects of GHRH and to treat proliferative diseases (particularly cancer), acromegaly or diabetic nephropathies and retinopathies.
Patent NZ-529013-A (NZ)
Title: Packaging bag with tear-off opening
Inventor: OBARA SHO
IPC: B65D33/00
Filed: 2002-04-25
Abstract: A packaging bag comprises a bag body (1), the first heat sealed portion (5), and the second heat sealed portion (5) and a tear-starting portion. The bag body is made of a plastic laminate film having a pair of opposite side edges (2, 3). The bag body is formed by bringing the pair of opposite side edges into contact with each other and heat-sealing them (4) over their entirety to form a tubular shaped body having a rear heat sealed (4) portion, and collapsing the tubular shaped body into a flatten shaped body having a front face, a rear face opposing the front face, a pair of opposite side edge (2, 3) portions connecting the front face and the rear face to each other, a first opened portion and a second opened portion opposing the first opened portion. The rear heat sealed portion is placed on the rear face. The first heat sealed portion is formed by heat-sealing the first opened portion (5). The second heat sealed portion is formed by heat- sealing the second opened portion (6). The tear-starting portion is provided on at least one of the pair of opposite side edge portions and the rear heat sealed portion. The tear-starting portion (7) comprises fine concavities opening outwardly.
Patent NZ-530701-A (NZ)
Title: Implantable gel compositions comprising compressed particles including the active agent in a bioerodible gel
Inventor: BRODBECK KEVIN J
IPC: A61K47/34
Filed: 2000-05-31
Abstract: Described is a composition containing a bioerodible gel and compressed particulates of an active agent, the particulates being dispersed within the bioerodible gel, wherein the bioerodible gel contains a polymer selected from the group consisting of polylactic acid, polyglycolic acid and poly(lactide-co-glycolic) acid and a solvent comprising an alkyl or aralkyl ester of benzoic acid; with the provisio that the compressed particulates do not include a hydrophobic agent. Also described is a process for the preparation of an implantable composition previously disclosed and preferably the active agent can be selected from the group consisting of human growth hormone, alpha-, beta-, or gamma-interferon, erythropoiten, glucagons, calcitonin, heparin, interleukin-1, interleukin-2, Factor VII, Factor IX, lutenizing hormone, relaxin, follicle-stimulating hormone, atrial natriuretic factor and filgrastim. (62) Divided out of 515911
Patent NZ-531413-A (NZ)
Title: Improved nitroreductase enzymes
Inventor: GROVE JANE ISABEL
IPC: A61K35/76
Filed: 2002-08-21
Abstract: Disclosed is a recombinant mutant nitroreductase encoded by a mutated E. coli NFSB gene, wherein the nitroreductase comprises a substitution of at least one of serine 40, threonine 41, tyrosine 68, phenylalanine 70, aspragine 71, glycine 120 or phenylalanine 124 and has an increased nitroreductase activity for CB1954 compared to the wild-type enzyme. The nitroreductase or an isolated polynucleotide encoding it, is used in the manufacture of a medicament for the treatment of cancer by conversion of a prodrug into an active cytotoxic compound.
Patent NZ-531597-A (NZ)
Title: Optical tools manipulated by optical traps
Inventor: GRUBER LEWIS
IPC: B82B3/00
Filed: 2002-09-03
Abstract: Micrometer and nanometer-sized tools (69), referred to as MOTS an d NOTS, respectively, are manipulated in the illumination (71) of an optical trap (70) and are able to alter the physical, chemical or electronic structure or orientation of a workpiece (68).
Patent NZ-532281-A (NZ)
Title: Orthopedic implant insertion instruments
Inventor: ROTH CHRISTOPH ANDREAS
IPC: A61B17/58
Filed: 2002-10-16
Abstract: Orthopedic implant insertion instruments for precision guiding of a fracture fixation implant into fractured bone to promote healing are disclosed. The implant insertion instruments include an insertion handle 40 for implantation of a first fixation implant, an aiming arm for precise guiding of a second fixation implant into bone, a guide sleeve for protection of soft tissue and for translational and rotational control of the second fixation implant, and a drive shaft with coupling screw for attachment to the second fixation implant and for driving the second fixation element through the aiming arm and guide sleeve into the fractured bone. The implant insertion instruments also include a soft tissue clearance device to aid the surgeon in inserting the first fixation implant into the fractured bone. Also disclosed is a measuring device that reduces measuring errors made by a user and a measuring device that determines implant length, diameter, and angle of insertion.
Patent NZ-533687-A (NZ)
Title: Embossing system with alignment posts
Inventor: CARLSON CHRISTOPHER ROBERT
IPC: B43L13/20
Filed: 2002-12-20
Abstract: An embossing system is disclosed comprising a base having a plurality of posts positioned on the outer portion thereof. A lower template (14) includes a plurality of shapes formed therein and a plurality of regions on the outer portion thereof for alignment with the posts. A textured plate (16) is positioned between the base and lower template (14), and an upper template (12) includes a plurality of regions on the outer portion thereof for alignment with the posts and the regions of the lower template (14). A plurality of shapes are formed on the upper template (12). The shapes on the upper template (12) align with the shapes of the lower template (14) when the posts and the regions of the upper template (12) and lower template (14) are in alignment.
Patent NZ-534616-A (NZ)
Title: Inflation valve assembly for a dunnage or cargo air bag
Inventor: SMITH RODNEY S
IPC: B60P7/06
Filed: 2004-08-10
Abstract: An inflation valve assembly, for a dunnage or cargo air bag, comprises an annular flange member which is adapted to be heat-sealed to an interior surface portion of one of the plies of the inflatable bladder of the air bag, and an externally threaded nipple portion for fluidic connection to a source of pressurized fluid for inflating the bladder of the dunnage or cargo air bag. A flapper valve member, having a substantially circular configuration, has an end portion which is adapted to be fixedly secured upon an arcuate portion of the upper surface portion of the annular flange member by a fixation bar which extends along a chordal extent of the annular flange member. Opposite end portions of the fixation bar project radially inwardly toward each other so as to effectively define a pair of oppositely disposed detents for maintaining the flapper valve member in its OPENED state.
Patent NZ-534832-A (NZ)
Title: Inhibitors of histone deacetylase
Inventor: VAN EMELEN KRISTOF
IPC: A61K31/497
Filed: 2003-03-11
Abstract: Disclosed are compounds of formula (I), wherein: n is 0-3, Q is N or C, X is N or C, Y is N or C, Z is N or CH, and the remaining substituents are defined herein. The compounds are used in the manufacture of medicaments for the treatment of proliferative diseases.
Patent NZ-534846-A (NZ)
Title: A water heater and a method of heating water in a tank with improvements in efficiency
Inventor: HAMMOND MARK KEITH
IPC: F24H1/20
Filed: 2003-02-11
Abstract: A water heater (10) includes: a tank (12) with a substantially central flue(14) having an outlet (22) substantially adjacent the top of the tank (12), the tank is adapted for mounting with the flue substantially vertical; a burner (28) located beneath the tank, the burner (28) adapted to burn a fuel to discharge heated gases up through the flue; a gas directing casing (30) around at least some of the exterior of the tank and spaced away from the at least some of the exterior of the tank to define a space (32) between the interior of the casing (30) and the at least some of the exterior of the tank, the space (32) having an inlet (34) substantially at or adjacent the bottom (16) of the tank and a relatively higher outlet; and a gas directing duct (38) remote from the tank exterior, the duct (38) adapted to direct the heated gases from the flue outlet to the space inlet without substantial heat transfer from the heated gases in the duct (38) to the tank exterior, wherein the heated gases sequentially flow from the burner (28), up the flue (14), down the duct (38) and through the space (32).
Patent NZ-535808-A (NZ)
Title: Micronized crystalline tiotropium bromide
Inventor: BENDER HELMUT
IPC: A61K31/40
Filed: 2003-03-10
Abstract: Micronized crystalline tiotropium bromide, processes for preparing it and its use for preparing a pharmaceutical composition, particularly for preparing a pharmaceutical composition with an anticholinergic activity are described. In particular, crystalline tiotropium bromide micronisate, characterized by a particle size X50 of between 1.0 um and 3.5 um at a Q(5.8) value of more than 60%, by a specific surface value in the range between 2m2/g and 5m2/g, by a specific heat of solution of more than 65 Ws/g and by a water content from about 1% to about 4.5%, is disclosed. The described pharmaceutical composition may be in the form of an inhalable powder and is useful in treating asthma or COPD.
Patent NZ-535872-A (NZ)
Title: Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors
Inventor: JAROCH STEFAN
IPC: C07D215/42
Filed: 2003-03-29
Abstract: Disclosed are compounds of general formula (I) in which: A stands for an optionally substituted aryl, benzyl or phenethyl group; R1 and R2 are independently of each other H, alkyl or (CO)-alkyl R3 is alkyl or partially or fully fluorinated alkyl; B means a methylene group optionally substituted by a methyl, ethyl or carbonyl group; and Q means an optionally substituted quinolyl or isoquinolyl group that is linked via any position. Also disclosed are processes of producing compounds of formula (I) and their use for treating inflammatory diseases.
Patent NZ-535873-A (NZ)
Title: A fluid dispensing device
Inventor: DAVIES MICHAEL BIRSHA
IPC: A61J7/00
Filed: 2003-05-07
Abstract: A fluid dispensing device (5, 105, 205, 305, 405, 505) is disclosed having a housing (9, 109, 209, 309, 409, 509) and a fluid discharge device (8, 108, 208, 308, 408, 508). The fluid discharge device (8, 108, 208, 308, 408, 508) is arranged to be actuated by one or more levers (20, 21; 120, 121; 170; 220, 221; 320, 321; 420, 421; 520) so as to apply a force transversely to the fluid discharge device (8, 108, 208, 308, 408, 508) which is used to move a container (30, 130, 230, 330, 430, 530) forming part of the fluid discharge device (8, 108, 208, 308, 408, 508) along a longitudinal axis of the fluid discharge device (8, 108, 208, 308, 408, 508) to cause actuation of a pump forming part of the fluid discharge device (8, 108, 208, 308, 408, 508). A pre-load means (28; 27, 28; 39,40; 41, 42, 44; 144, 47a, 47b; 150, 152, 153); 224, 227; 342; 424a, 446; 425a; 427, 428; 560, 561) is used to prevent actuation of the pump until a pre-determined force is applied to each lever (20, 21; 120, 121; 170; 220, 221; 320, 321; 420, 421; 520) of sufficient magnitude to guarantee the production of a well developed efficient spray from the fluid dispensing device (5, 105, 205, 305, 405, 505).
Patent NZ-539627-A (NZ)
Title: A nutraceutical composition comprising pericarp from fruit of Garcinia mangostana L. tree
Inventor: GARRITY AARON R
IPC: A23L19/00
Filed: 2003-10-30
Abstract: Disclosed are nutraceutical compositions derived from the fruit of the Garcinia mangostana L. or mangosteen plant. The nutraceutical mangosteen compositions employ combinations of mangosteen fruit pulp and pericarp, and can be additionally complemented by selected juice concentrates to yield a composition for improving general health and wellness in humans.
Patent NZ-541731-A (NZ)
Title: An adjustable screw-in post support, with helical blade on shaft of post and inter-engaging curved domes between shaft and upper section of post
Inventor: WALKER SIMON
Filed: 2005-08-10
Abstract: An adjustable screw-in post support is disclosed for use in supporting a post vertically above the ground. The adjustable screw-in post support has a shaft with a helical blade affixed thereto at one end and a shaft plate affixed thereto at the opposite end. The post support also includes a post-receiving unit mounted atop a base plate. The shaft and base plate cooperate with one-another to provide adjustment of the post-receiving unit relative to one-another and are held together by a fastener.
Patent NZ-541911-A (NZ)
Title: Harvesting device comprising flexible links for a machine for harvesting fruits, berries and the like
Inventor: MERANT JEAN-CAMILLE
IPC: A01D46/28
Filed: 2004-05-27
Abstract: A harvesting device comprises two shaker assemblies (5) mounted face-to-face on a straddle carrier frame (9) for shaking fruit-bearing trees or bushes. Each shaker assembly comprises a plurality of horizontal flexible material rods (22) having a first end (22a) detachably fixed to an oscillatory vertical support (19), a median portion (22c) adapted to act on the fruit-bearing trees or shrubs to shake them, and a second end (22b) connected to the frame (9) by a connecting link (23) that is grosso modo horizontal and perpendicular to a vertical median plane of symmetry of the frame. Hence, in operation, the second end of the rod is maintained at a substantially constant distance from the vertical median plane of symmetry. The connecting link is fixed to the frame by a rigid connection (41) and is flexible in a substantially horizontal plane, so that, in operation, the end of the connecting link adjoining the rod moves to-and-fro substantially horizontally in a direction substantially parallel to the vertical median plane of symmetry.
Patent NZ-543654-A (NZ)
Title: GITR ligand and GITR ligand-related molecules and antibodies and uses thereof
Inventor: COLLINS MARY
IPC: A61K39/00
Filed: 2004-05-24
Abstract: Provided is an isolated specific nucleic acid molecule coding for GITRL , which is capable of binding GITR, host cells and non-human transgenic animals expressing the protein, corresponding antisense oligonucleotides and antibodies, methods of screening and diagnosis using the compositions and use of the such GITR antagonists in the manufacture of a medicament to treat various diseases. Also provided are various vaccine adjuvants comprising a GITR agonist and an antigen.
Patent NZ-552086-A (NZ)
Title: Fused benzamide compound and vanilloid receptor 1 (VR1) activity inhibitor
Inventor: KOGA YOSHIHISA
IPC: A61P29/00
Filed: 2005-07-14
Abstract: A fused benzamide compound represented by the following formula (1) (wherein the symbols in the formula have the same meanings as defined in the description), which inhibits VR1 activity; or a salt of the compound. The compound and salt have the excellent function of inhibiting VR1 activity and are effective in the treatment of diseases in which vanilloid receptor 1 (VR1) activity participates, such as pains, acute pains, chronic pains, neuropathic pains, pains of chronic articular rheumatism, and neuralgia.
Patent NZ-554929-A (NZ)
Title: Ophthalmic oil-in-water type emulsion with stable positive zeta potential
Inventor: BAGUE SEVERINE
IPC: A61K9/00
Filed: 2005-10-10
Abstract: Disclosed is an ophthalmic oil-in-water submicron type emulsion, which comprises colloid particles having an oily core surrounded by an interfacial film, said emulsion comprising: a) 0.001% to 0.1% by weight of at least one cationic agent selected from the group consisting of tertiary aliphatic amines, quaternary ammonium compounds, cationic lipids, amino alcohols, biguanide salts, cationic polymers and a mixture of two or more thereof; b) less than 1% by weight of at least one non ionic surfactant selected from the group consisting of tyloxapol, polysorbates, polyoxyethylene castor oil derivatives, sorbitan esters, polyoxyl stearates and a mixture of two or more thereof; wherein said emulsion meets the zeta potential stability Test A requirement (as defined herein), and provided that the emulsion does not contain phospholipids. Also disclosed is an ophthalmic emulsion as defined above which further comprises an immunosuppressive agent selected from the group consisting of cyclosporine (such as cyclosporin A), sirolimus and tacrolimus. Further disclosed is a process for the preparation of a submicron ophthalmic oil in-water type emulsion as defined above which comprises the steps of shear mixing followed by high pressure homogenization of the coarse emulsions obtained through mixing of the aqueous and the oily phase. The use of a submicron oil-in-water emulsion as defined above for the preparation of an ophthalmic composition for treating dry-eye conditions is also disclosed.
Patent NZ-565365-A (NZ)
Title: A lock and key system with code patterned tumblers
Inventor: WIDEN BO
IPC: E05B15/12
Filed: 2006-07-26
Abstract: A lock and key system is disclosed including locks of the kind comprising a cylindrical key plug (203) with locking tumblers having a body part (206a) and an integral key sensing part (206b) for engagement with an associated key (101) . The key sensing part of each locking tumbler comprises at least two neighbouring key contacting portions (210, 211) being mutually displaced from each other longitudinally along the key plug axis and being confined within a limited region, for possible sliding engagement with a longitudinal code pattern of the associated key, at least one but not necessarily all of these key contacting portions of each locking tumbler actually engaging with a corresponding code portion of the associated key upon fully inserting the latter into the key slot of the lock.
Patent NZ-566815-A (NZ)
Title: Externally-applied patient interface system and method
Inventor: BUBB STEPHEN K
IPC: A61M35/00
Filed: 2006-10-03
Abstract: Disclosed is a dressing assembly for a wound or incision. The assembly comprises an external patient interface including an external fluid transfer component that fluid from the wound. The external patient interface includes an overdrape placed over the fluid transfer component in contact with a surrounding skin surface. The fluid transfer component includes a porous core with a surface and a wicking material layer engaging the surface.
Patent NZ-568733-A (NZ)
Title: Structure for modulating intraocular pressure
Inventor: HSU WEI-CHERNG
IPC: A61F2/14
Filed: 2008-05-30
Abstract: Disclosed is a scaffold comprising at least two polymers in an amount that produces: a saturated static pressure of about 0.5 mmHg to about 5.5 mmHg, after saturation in saline; and a stiffness of about 0.5 KPa to about 2 KPa after saturation in saline wherein a first polymer is selected from the group consisting of collagen or gelatin and a second polymer is selected from the group consisting of chonroitin-6-sulfate, heparin, heparan sulphate, keratan sulphate, dermatan sulphate, chiton and chitosan and wherein the scaffold is substantially free of aldehydes and aldehyde remnants.
Patent NZ-569097-A (NZ)
Title: Method for providing a rapidly usable low-cost transport system for biologically active substances that permits effective and reliable transport of active ingredients in the animal organism
Inventor: REHM BERND HELMUT ADAM
IPC: C12P7/62
Filed: 2003-08-22
Abstract: A process for producing polymer particles having surface-bound proteins is disclosed, wherein the process comprises: (A) providing a cell comprising one or more genes that code for one or more fusion proteins, the fusion proteins comprising a polymer synthase, and (a) one or more binding domains capable of binding one or more biologically active substances or one or more coupling reagents or a combination thereof, or (b) one or more biologically active proteins, or (c) a combination thereof, the polymer synthase comprising a polymer particle binding domain; and (B) cultivating the cell in a culture medium so that the cell produces the fusion protein from the one or more genes and the fusion protein produces polymer particles, wherein the polymer particle binding domain of the fusion protein is covalently bound to a polymer particle; and (C) separating the polymer particles from the cultivated cells to produce a composition comprising polymer particles having surface-bound proteins.
Patent NZ-569868-A (NZ)
Title: Prophylactic docosahexaenoic acid therapy for patients with subclinical inflammation
Inventor: ARTERBURN LINDA M
IPC: A61K31/202
Filed: 2003-09-29
Abstract: Disclosed is the use of a formulation or oil comprising fatty acids in the manufacture of a medicament for treating a cerebrovascular disease in an individual having C-Reactive Protein (CRP) as an inflammatory marker, wherein the medicament is formulated for daily oral administration for at least about 6 months, the formulation or oil comprises docosahexaenoic acid (DHA) in an amount of about 1 g/day to about 4 g/day, and the formulation or oil contains no other omega-3 PDFA (polyunsaturated fatty acid) equal to or greater than 4% of the total fatty acid content. (62) Divided Out of 539624