Patent SG-11201809928V-A (SG)
Title: Modified antimicrobial peptide derived from an arginine-rich domain
Inventor: SHIH CHIAHO
IPC: C07K14/005
Filed: 2017-05-25
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) - (19) World Intellectual Property Organization - - 1111111111111111111111111111111111111111111111111111111111011111111111111111111111 ' International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/205631 Al 30 November 2017 (30.11.2017) WIPO I PCT (51) International Patent Classification: emia Sinica, Taipei City, 11529 (TW). SU, Pei-Yi; 128 C07K 14/005 (2006.01) A01N 37/46 (2006.01) Academia Rd., Sec. 2, Nangung, Institute Of Biomedical C07K 7/08 (2006.01) A01N 63/00 (2006.01) Sciences, Academia Sinica, Taipei City, 11529 (TW). (21) International Application Number: (74) Agent: WU, Jeannie; Cesari and McKenna, LLP, 88 Black PCT/US2017/034489 Falcon Avenue, Boston, MA 02210 (US). (22) International Filing Date: (81) Designated States (unless otherwise indicated, for every 25 May 2017 (25.05.2017) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (25) Filing Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (26) Publication Language: English DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (30) Priority Data: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, 62/342,415 27 May 2016 (27.05.2016) US MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (71) Applicant: ACADEMIA SINICA; Office of Public Af- PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, fairs, (Technology Transfer) (05), 128, Sec. 2, Academia SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, Sinica Rd., Nan-Kang, Taipei (TW). TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventor; and (84) Designated States (unless otherwise indicated, for every _ (71) Applicant: SHIH, Chiaho [US/ ]; 128 Academia Rd. kind of regional protection available): ARIPO (BW, GH, Sec. 2, Nangung, Institute of Biomedical Science, Acade- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, mia Sinica, Taipei City, 11529 (TW). UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = Inventors: CHEN, Heng-Li; 128 Academia Sinica Rd., EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, — (72) Sec. 2, Nangung, Institute Of Biomedical Sciences, Acad- = _ Title: MODIFIED ANTIMICROBIAL PEPTIDE DERIVED FROM AN ARGININE-RICH DOMAIN (54) = FIG. 1 = = = = M IV : „ „ ,„ ' PrP --- - R RR:RR.:z — is'E = = :1 2PR: 1 :: .;, ::\",:\"...\" ::::; :' :.'.:'':: :'RRRR::::c: = ..1 - .ralu - 41:.;::::; :..<i. , 3P Rte. 1P SPRRRRS i : — 1. , 3 . ..>: . , i:: = = , .:11RI.L . 1:., , PAR . IIR:::;c:!:.:: :• ' = = =_ 0 w P:\" :11 ' . 1(‘T.T . ,.: - TC : J-: _ FTYP; ' MMIP 11R-15::; FRG r:RRRMI : : RRRSIC.; RERS . :]; \" 1-1 NT)3:::: R.R.RSK:::: R.: M in G ` R.R.R : 4r:.; R > ER R.:::',:]- 64 Sti<R PRRRIWK.:ZI - P -,— ---...— \" . 0 N ---- (57) : An antimicrobial peptide, the peptide comprising 2 to 20 variable domains, each variable domain is a sequence of 2 to IN ,- 1 20 consecutive basic amino acids, wherein (a) the variable domains are separated from each other by a variable linker, (b) the variable 0 linker can have 1 to 20 any amino acids other than two or more consecutive basic amino acids, and (c) the peptide has no more than N 100 amino acids. C [Continued on next page] WO 2017/205631 Al MIDEDIM00010101110101110010101g1110110MOII1110VOIMIE MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))