baber/WOPTO huggingface dataset:
Patent UA-119537-C2 (UA)
Title: Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines for treating lymphomas
Inventor: LIU NINGSHU
Filed: 2014-04-04
Abstract: - use of a 2,3-dihydroimidazo[1,2-c]quinazoline compound, or of a pharmaceutical composition containing same, as a sole active agent, or of a combination of a) said compound or a pharmaceutical composition containing said compound and b) one or more fu rther active agents, for the preparation of a medicament for the treatment or prophylaxis of non-Hodgkin's lymphoma (NHL), particularly 1st line, 2nd line, relapsed, refractory, indolent or agressive non-Hodgkin's lymphoma (NHL), in particular follicular lymphoma (FL), chronic lymphocytic leukaemia (CLL), marginal zone lymphoma (MZL), diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), transformed lymphoma (TL), or peripheral T-cell lymphoma (PTCL); - combinations of a) said compound and b) one or more further active agents; - a pharmaceutical composition comprising said compound as a sole active agent for the treatment of non-Hodgkin's lymphoma (NHL), particularly 1st line, 2nd line, relapsed, refractory, indolent or agressive non-Hodgkin's lymphoma (NHL), in particular follicular lymphoma (FL), chronic lymphocytic leukaemia (CLL), marginal zone lymphoma (MZL), diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), transformed lymphoma (TL), or peripheral T-cell lymphoma (PTCL); - a pharmaceutical composition comprising a combination of a) said compound and b) one or more further active agents; - use of biomarkers involved in the modification of the expression of PI3K isoforms, ВТК and IKK,, BCR activation, BCR downstream activation of NFKB pathway, c-Myc, EZH2, for predicting the sensitivity and/or resistance of a cancer patient to said compound and providing a rationale-based synergistic combination as defined herein to increase sensitivity and/or to overcome resistance; and - a method of determining the level of a component of one or more of the expression of PI3K isoforms, ВТК and KK,, BCR activation, BCR downstream activation of NFKB pathway, c-Myc, EZH2.
Patent UA-114368-C2 (UA)
Title: Спосіб визначення шлуночково-перегородкового кута (шпк) серця
Filed: 2015-12-07
Abstract: Винахід належить до медицини і стосується способу визначення шлуночково-перегородкового кута (ШПК) серця, що включає отримання гістологічних препаратів з підготовлених парафінових блоків із цілим серцем, попередньо обробленим формаліном та спиртом, з яких виготовляють зрізи цілого серця у горизонтальній площині товщиною 5 мкм, які фарбують, далі отримані гістологічні препарати фотографують за допомогою цифрової фотокамери через мікроскоп, після чого здійснюють побудування та вимірювання кута взаємного розташування вільної стінки лівого шлуночка (ЛШ) та міжшлуночкової перегородки (МШП).
Patent UA-122047-C2 (UA)
Title: Застосування фармацевтичної композиції, що містить пептид, як лікарського засобу для знищення клітин-мішеней в організмі пацієнта
Inventor: WEINSCHENK TONI
IPC: A61K39/00
Filed: 2011-03-15
Abstract: Винахід стосується застосування пептиду, нуклеїнової кислоти та клітини для імунотерапії. Зокрема, цей винахід стосується імунотерапії раку. Цей винахід має також відношення до епітопів пухлино-асоційованих пептидів цитотоксичних Т-клітин (ЦТЛ), які самостійно або в комбінації з іншими пухлино-асоційованих пептидами служать активними фармацевтичними інгредієнтами композицій вакцин, які стимулюють протипухлинні імунні реакції. Цей винахід стосується нових пептидних послідовностей та їх варіантів, отриманих із молекул HLA І класу клітин пухлин людини, які можуть використовуватись у вакцинних композиціях з метою викликати протипухлинну імунну відповідь.
Patent UA-120503-C2 (UA)
Title: Optimal maize loci
Inventor: SASTRY-DENT LAKSHMI
Filed: 2014-11-03
Abstract: As disclosed herein, optimal native genomic loci from maize plants have been identified that represent best sites tor targeted insertion of exogenous sequences.
Patent UA-122622-C2 (UA)
Title: Спосіб визначення схильності гірської породи до раптового обвалення
Filed: 2019-03-18
Abstract: Спосіб визначення схильності гірської породи до раптового обвалення включає відбір проб гірської породи у вигляді штуфа, виготовлення з нього зразків і проведення випробувань. Одну частину штуфа подрібнюють до 0,4-0,5 мм, а іншу частину використовують для виготовлення зразків кубічної форми. Подрібнену частину зразка висушують до температури (200-800 °C) і розраховують енергію активації дегідратації води . Зразки кубічної форми використовують для визначення енергії змінення форми гірської породи в умовах позамежної деформації. Визначають схильність гірської породи до раптового обвалення як відношення величини енергії активації дегідратації води до енергії змінення форми , а саме: , і вважають, якщо , то гірська порода схильна до раптового обвалення. Спосіб дозволяє заздалегідь здійснювати локальний прогноз місця гірської виробки, схильного до раптового обвалення.
Patent UA-125753-C2 (UA)
Title: Спосіб проведення виробок комбайном у викидонебезпечних пластах вугілля та гірських порід
Filed: 2019-04-11
Abstract: Винахід належить до гірничої промисловості і може бути використаним для проведення виробок у викидонебезпечних пластах вугілля та гірських порід.  Спосіб полягає в проведенні змішаним вибоєм підготовчої виробки з вибірковим вийманням комбайном шарів вугілля та гірських порід і постійним акустичним контролем викидонебезпечності. Для товщини пласта газонасичених гірських порід менше 2 м, що знаходиться у поперечному перерізі виробки, виймання комбайном здійснюють із створенням випереджаючої розвантажувальної порожнини постійної глибини 0,5 м. При цьому спочатку виймають вугільний пласт і прилеглі до нього гірські породи, залишаючи запобіжний шар 0,5-1,0 м цих порід до газонасичених порід. Потім виймають тільки запобіжний шар породи на глибину циклу, після чого - шар газонасичених викидонебезпечних порід також на глибину циклу. Забезпечується безпечне проведення виробок у викидонебезпечних пластах вугілля та гірських порід і зменшується вартість гірських робіт.
Patent UA-125198-C2 (UA)
Title: Pyrrolobenzodiazepine-antibody conjugates
Inventor: VAN BERKEL PATRICIUS HENDRIKUS CORNELIS
Filed: 2018-02-08
Abstract: A conjugate of formula (I): Ab − (DL)p wherein: Ab is an antibody that binds to AXL; DL is formula (A).
Patent UA-76498-C2 (UA)
Title: Safe twin tackle
Inventor: STUKALENKO MYKHAILO IVANOVYCH
IPC: B66C15/00
Filed: 2004-04-15
Abstract: The invention concerns hoisting machines, namely, the design of safe twin tackles, forming part of lifting systems and preventing from dropping of the load in case of rope break. A safe twin tackle contains a mobile pulley block bent by ropes, some ends of which are fixed on the winch drum, and other ends - on the equalizing drum, internal space of which is divided into two hollows by two longitudinally located plates. One of the plates is mobile and is fixed on internal surface of the shell of drum, and the second one is fixed and fastened on its shaft. The hollows are filled with liquid, for overflow of which from one cavity into another at appropriate resistance there are choke elements. The choke elements are corresponding section of internal surface of mobile plate and choke groove executed on the surface of shaft is perpendicular to its axis, the groove in its middle part has constant section, and along the sides - variable section. Technical result consists in simplification of the design, procedures of manufacture and assembly of the unit of equalizing drum.
Patent UA-75737-C2 (UA)
Title: Device for the visualization of spatially-heterogeneous magnetic field by thermomagnetic effect
Inventor: PROKOPOV ANATOLII ROMANOVYCH
IPC: G02F1/09
Filed: 2004-05-11
Abstract: The proposed device for the visualization of spatially-heterogeneous magnetic field by thermomagnetic effect contains a magnetooptic converter, a current pulse source, and a recording unit. The magnetooptic converter contains a crystalline substrate with epitaxial film produced from garnete-type ferrite, reflecting coating, antireflecting coating, and contact pads. The Curie temperature of the epitaxial film is no less than 40 ?C and is ensured by the presence of aluminium, gadolinium, and scandium additives. The coercivity of the epitaxial film is about 20 Oe and is assured by the selection of the supercooling temperature of the melt in growing the epitaxial film and the following polishing of the film. The proposed device is distinctive by its enhanced picture contrast and improved performance.
Patent UA-78998-C2 (UA)
Title: Sensor unit
Inventor: BOIUN VITALII PETROVYCH
IPC: G01N21/55
Filed: 2004-12-27
Abstract: The invention relates to means of optoelectronics and sensor engineering for implementation of investigations in food industry, agriculture, medicine, material science, biology and ecology. Sensor unit has body in which two parallel channels are provided, in one of those in sequence are placed optically connected strip semiconductor laser, polarizer and focusing lens, in the other -photosensitive PZZ-matrix and aperture diaphragm. Lighting and photo-receiving channels are optically connected to retroprism with sensitive receptor film and mirror coating placed at one of faces at angle 90 DEGREE to receptor prism. Retro-prism is placed in non-transparent case and connected to the body by springy link and control screw, at that between retroprism and body there is controlled within +- (2 DEGREE -5 DEGREE ) wedge-like gap. Strip semiconductor laser has dimension of emitting range from 3 mkm to 5 mkm. Distance from focus of convergent beam to photo-sensitive PZZ matrix is as such that PZZ matrix covers needed range of reflection from receptor film angle change, angle range in measurements is 72+- 5 DEGREE . The invention makes it possible to increase resolving capacity, to increase and to control angle range of measurements.
Patent DE-3835367-C5 (DE)
Title: Vorrichtung für Mähwerke zur Bodenanpassung der Schneidwerke
Inventor: NUSSER JOSEF
IPC: A01D34/66
Filed: 1988-10-18
Granted: 2016-09-29
Abstract: nichtig
Patent DE-10310420-C5 (DE)
Title: Wassersammelvorrichtung
Inventor: FEIL ALFRED
IPC: B01D21/00
Filed: 2003-03-11
Granted: 2008-02-07
Abstract: Wassersammelvorrichtung
zur Sammlung, Reinigung und Weiterleitung von Quellwasser mit einem
Quellsammelschacht, aufweisend einen geschlossenen Behälter (1)
mit eigenen, vom Quellsammelschacht unabhängigen Wandungen, wobei der
Behälter
(1) mindestens einen Behältereinsatz
(2) aufweist, wobei der Behälter
(1) einen zylindrischen Abschnitt (5) und mindestens einen weiteren,
sich nach unten anschließenden,
konischen Abschnitt (6) mit sich verjüngender horizontaler Querschnittsfläche aufweist,
wobei eine Wasserzufuhrleitung (3) und eine Wasserentnahmeleitung
(4) vorgesehen sind, wobei Wasserzufuhrleitung (3) und Wasserentnahmeleitung
(4) getrennt voneinander in den oberen Bereichen von Behälter (1)
bzw. Behältereinsatz
(2) angeordnet sind, wobei der konische Abschnitt (6) an seiner
Spitze eine Öffnung
(7) aufweist, wobei der Behältereinsatz
(2) innerhalb des Behälters,
konzentrisch um eine Behälter-Hochachse
(8) angeordnet ist, dadurch gekennzeichnet, dass der Behältereinsatz
(2) am oberen Rand des Behälters
(1) befestigbar ausgebildet ist und der Behältereinsatz (2) einen zylindrischen
Abschnitt (9) und mindestens einen weiteren, sich nach unten anschließenden konischen
Abschnitt (10) mit sich verjüngender
horizontaler...
Patent RU-2420504-C9 (RU)
Inventor: LANGE ARNO
IPC: C07C5/03
Filed: 2006-05-11
Granted: 2012-06-20
Abstract: FIELD: chemistry. ^ SUBSTANCE: invention relates to a mixture of isoalkanes as oil bodies for cosmetic or pharmaceutical agencies, whose 1H-NMR-spectrum in the region of a chemical shift of from 0.6 to 1.0 ppm relative tetramethylsilane, has a surface integral of from 25 to 70% of the total integral surface. The mixture, which has density from 0.7 to 0.82 g/cm3, contains not less than 70 wt % alkanes with 8-20 carbon atoms, and the fraction of side chains with alkyl groups which have 2 or more carbon atoms is less than 20% of the total number of branching sites and is free from squalane. The invention also relates to a method of preparing said mixture, as well as a cosmetic or pharmaceutical agent based on said mixture and a hair cosmetic agent also based on said mixture. ^ EFFECT: improved method. ^ 24 cl, 2 tbl, 809 ex
Patent DK-30391-D0 (DK)
Inventor: ALBAYRAK CELAL
IPC: A61K49/04
Filed: 1991-02-21
Abstract: The invention relates to the use of cavity- or clathrate-forming host/guest complexes as contrast media in ultrasonic, X-ray or NMR investigations.
Patent DK-72191-D0 (DK)
Inventor: LEE JERALD DANA
IPC: B65H69/02
Filed: 1991-04-19
Abstract: A fiber optic switch has a fixed member and a movable member mounted for cantilevered movement with respect thereto. Both of the members are fabricated from borosilicate glass.
Patent DK-251784-D0 (DK)
Inventor: SIMON ARTHUR
IPC: C07C303/00
Filed: 1984-05-22
Abstract: A process is provided for preventing or ameliorating arrhythmia by administering to mammals, including man, an effective dose of d-sotalol to lengthen the action potential duration of cardiac cell without blockade of beta-adrenergic receptor sites.
Patent DK-379387-D0 (DK)
Inventor: DEMUTH MARTIN
IPC: C07D319/06
Filed: 1987-07-21
Abstract: Disclosed are new 1,3-dioxenones having the formulae <CHEM> in an optically pure state, a process for preparing same and the use thereof.
Patent DK-400686-D0 (DK)
Inventor: PIEH STEFAN
IPC: C08G16/02
Filed: 1986-08-22
Abstract: Use of salts of water-soluble naphthalenesulfonic acid formaldehyde condensates having a molar formaldehyde/naphthalenesulfonic acid ratio of 1.2:1 to 3:1 and an intrinsic viscosity of 0.01 to 0.15 dl/g, as an additive to inorganic binders for improving the flowability, and a structural material prepared using binders modified in this manner.
Patent DK-402786-D0 (DK)
Inventor: GRANT ALEXANDER
IPC: E05D1/04
Filed: 1986-08-22
Abstract: The hinge comprises first and second components (l0,l2) for attachment to respective structural members. A substantially cylindrical surface (26) on the second component (l2) snap-fits into a part-cylindrical bearing surface (20) on the first component (l0). The components (l0,l2) have interengaging formations which act to resist closing over a predetermined arc; in the embodiment shown one set of interengaging formations comprises blades (28) sliding in slots (22), and another set comprises protrusions (32,34).
Patent DK-497288-D0 (DK)
Inventor: HARTOG JAN
IPC: C07D319/18
Filed: 1988-09-07
Abstract: It has been found that a group of piperazine derivatives known to have blood-pressure lowering properties possess good anxiolytic properties. In two well known animal test models the compounds are active when used intraperitoneally in dosages of 0.3 mg/kg.
Patent DK-498684-D0 (DK)
Inventor: ADGER BRIAN MICHAEL
IPC: C07D405/14
Filed: 1984-10-18
Abstract: A process for preparing 2-(2-(5-dimethylaminomethylfuran-2-ylmethylthio)ethylamino)-5-(2-metho xypyrid-4- ylmethyl)pyrimidin-4-one which comprises reacting 2-(2-(furan-2-ylmethylthio)ethylamino)-5-(2-methoxypyrid-4-ylmethyl)py rimidin-4- one with a organic solution of bis(dimethylamino)methane at a pH of about 1.3 to about 2.5. The product is an H2-antagonist and also is of value in forming 2-(2-(5-dimethylaminomethylfuran-2-yl-methylthio)ethylamino)-5-(2-hydr oxypyrid-4 -ylmethyl)pyrimidin-4-one by deprotecting.
Patent DK-534283-D0 (DK)
Inventor: BATEMAN NEIL E
IPC: C07C67/14
Filed: 1983-11-22
Abstract: An analgesic and anti-inflammatory product comprising a compound having the formula: <CHEM> wherein R and R<1> are hydrocarbon radicals and process for the manufacture thereof.
Patent DK-534287-D0 (DK)
Inventor: PARRENT GEORGE B
IPC: G01N35/00
Filed: 1987-10-13
Abstract: In a chemical analysis apparatus a controlled sample liquid is passed through a non-wetting porous membrane (23) in a diluter assembly (12) from a reservoir of sample liquid to a flowing stream of diluent which is constantly flowing. The sample liquid penetrates the membrane (23) under a positive pressure differential from the sample side of the membrane (23). Control is provided by varying the resistance to flow of the sample liquid, and the pressure on the sample liquid, as it flows through the diluter assembly (12). Passage of the sample liquid through the membrane (23) requires a minimum liquid entry pressure differential across the membrane (23) to cause enough penetration to give a detectable presence of the sample liquid in the diluent stream for analysis by an analytical detector (19).
Patent DK-555583-D0 (DK)
Inventor: RUEHL ERICH
IPC: C08K3/22
Filed: 1983-12-02
Abstract: The non-flammable rigid foam e.g. used as a building material complies with the requirements of DIN 4102 and which provides a non-toxicity of the combustion fumes according to DIN 53436. It has a mass ratio of resin component: filler of at least 1:2.5 and a bulk density amounting to 50 kg/m3 to 450 kg/m3. The resin component is formed by reaction of 50-62 mass parts resolic resin 0-15 mass parts furane resin 25-40 mass parts furfuryl alcohol 0.5-11.5 mass parts foam stabilizer including 14-17 mass parts per 100 mass parts of resin component plus filler of a curing agent mixture of phosphoric acid, boronhydrofluoric acid, p-toluene sulphonic acid and water. The filler used is a mixture of 40-55 mass % aluminium hydroxide 10-35 mass parts boric acid 2-7 mass parts sodium tetraborate 5-10 mass parts manganese dioxide 1-5 mass parts copper-II-oxide 1-4 mass parts magnesium hydroxysilicate 1-2 mass parts aluminium silicate.
Patent DK-561588-D0 (DK)
Inventor: STRICKER HERBERT
IPC: A61K9/52
Filed: 1988-10-07
Abstract: The system consists of a carrier material based on poly-D,L-lactide and of a drug incorporated therein and, where appropriate pharmaceutical auxiliaries. The carrier material contains defined contents of additives in the form of pore formers, up to about 10% by weight of a physiologically acceptable solvent or plasticiser and/or low molecular weight polymers.
Patent DK-713088-D0 (DK)
Inventor: GAWELL LARS IVAR
IPC: C07C221/00
Filed: 1988-12-21
Abstract: Compounds with the general formula I <CHEM> wherein n is 0 or 1, Z is CO or CH(OH), R<1> and R<2> are equal or different and, when equal, hydrogen, methyl, ethyl or propyl and, when different, R<1> is hydrogen and R<2> is methyl, ethyl, propyl or isopropyl, X and Y represent hydrogen, halogen, CF3, CN or an alkyl group, straight or branched having 1-3 carbon atoms, in the ortho, meta or para position provided that when X is in the ortho position and other than hydrogen then Y is other than hydrogen, and when Y is in the ortho position and other than hydrogen then X is other than hydrogen, R represents a straight or branched saturated or unsaturated 1-6 carbon alkyl group, a 3-6 carbon cycloalkyl group, a phenyl group, which may be unsubstituted or may carry a ring substituent X<1>, X<1> preferably being a halogen, or R represents hydrogen, in racemic or optically active form and when Z is CH(OH) also mixtures of diastereomers or a pure diastereomer, with the proviso that the racemate of the compound wherein R<1> and R<2> is hydrogen, X is p-Cl, Y is hydrogen, Z is CO, n is 0 and R is methyl is excluded, or pharmaceutically acceptable salts thereof, processes for the production of said compounds and the use of the said compounds for the treatment of mental disturbances.
Patent HU-9301816-D0 (HU)
Title: Glue for stabilizing artificial teeth
Inventor: MACKAY BRUCE JOHN
IPC: A61K6/00
Filed: 1991-12-16
Abstract: Disclosed are stabilizer compositions comprising specific mixed partial salts of a lower alkyl vinyl ether-maleic acid copolymer wherein said partial salts containing from about 10 % to about 40 % free acid, and as the cationic salt function: (a) from about 0.1 % to about 9.9 % zinc or strontium cations; (b) from about 0.1 % to about 25 % sodium cations; and (c) from about 20 % to about 70 % calcium cations of the total initial carboxyl groups reacted and wherein said compositions have a taste index of below about 0.7. Also disclosed are denture stabilizing compositions comprising these mixed partial salts, as well as denture stabilizing compositions comprising a safe and adhesively effective amount of two or more denture adhesive components wherein one of said denture adhesive components is the mixed partial salt(s) of the present invention.
Patent NO-862979-D0 (NO)
Inventor: HENRICI DIETER
IPC: H01R4/48
Filed: 1986-07-24
Abstract: The electrical connector block comprises an insulating body and a plurality of conductor terminals mounted in it of which at least one is a protective conductor terminal. It is provided with an additional contacting member which passes through the base of the insulating body facing a connector block support and has at least one exterior plug which can directly make contact in a socket in the connector block support. The protective conductor plug can be mounted in the connector block during manufacture of the connector block or also subsequently to making the connector block without having to dismantle it. The structure and positioning of the protective conductor plug or plugs allows an easy automatic connection to the protective conductor by plugging the conector block into the connector block support.
Patent NO-871649-D0 (NO)
Inventor: SCHRAVEN PETRUS E G
IPC: B65D85/26
Filed: 1987-04-22
Abstract: Packaging material for relatively rigid objects, said material consisting of a metal foil coated with a layer of a plastic material, whereby an aluminum foil is applied on a creped basic layer of a plastic material or paper, said foil is coated with a protective layer.
Patent NO-875297-D0 (NO)
Inventor: KIDNER KJELL
IPC: F16K17/168
Filed: 1987-12-17
Abstract: A safety valve (1) for fluid comprising an inlet (I) and an outlet (U) for the fluid in question and a passage (63) running between the inlet (I) and the outlet (U). A control valve (2) for the pressurized flow communicating with the inlet (I), which valve consists of a moving piston (6) and a piston valve (8) capable of actuation by spring force, which piston valve is so arranged as to interact with a passage (9) running through said control piston (6) and is actuated by a spring force which is less than the resulting pressure drop between the inlet (I) and the outlet (U), is so arranged as to be actuated by the pressure difference in question between the inlet side (I) and the outlet side (U) of said control valve (2), by which means the flow of fluid creates a pressure drop between the inlet (I) and the outlet (U). The valve (1) functions efficiently and is controlled automatically by the prevailing pressure.
Patent NO-881396-D0 (NO)
Inventor: PLESTER GEORGE
IPC: G01N21/31
Filed: 1988-03-29
Abstract: Methods of discriminating between contaminated and uncontaminated containers prior to washing is disclosed characterized by the testing of the residue of the container to determine if the residue is residue of the original product packed in the container. If the residue is not sufficiently similar to the original product, the container is rejected as contaminated.
Patent NO-883554-D0 (NO)
Inventor: DORSCHUG MICHAEL
IPC: C07K19/00
Filed: 1988-08-10
Abstract: Basic proteins are isolated from protein mixtures which contain such basic proteins and which are obtained by enzymatic clevage of proinsulin and/or its derivatives of natural, semisynthetic or genetic engineering origin by ion exchanger chromatography on strongly acid cation exchangers.