baber/WOPTO huggingface dataset:
Patent AU-2019288484-A1 (AU)
Title: Cytokine-based bioactivatable drugs and methods of uses thereof
Inventor: LI YUE-SHENG
IPC: C07K2/00
Filed: 2019-06-20
Abstract: The present disclosure provides a cytokine-based bioactivatable drug construct ("VitoKine") platform that aims to reduce systemic mechanism-based toxicities and lead to broader therapeutic utility for proteins and cytokines such as IL-15 and IL-2 for the treatment of cancer, autoimmune diseases, inflammatory diseases, viral infection, transplantation and various other disorders. The novel VitoKine constructs of the present invention comprise: 1) a tissue or disease site targeting moiety D1 domain ("D1"), 2) a bioactivatable moiety D2 domain ("D2"), and a concealing moiety D3 domain ("D3"). Importantly, because the "active moiety" of the VitoKine construct will remain inert until activated locally by proteases that are upregulated in diseased tissues, this will limit binding of the active moiety to the receptors or to the targets in the peripheral or on the cell-surface of non-diseased cells and tissue to prevent over-activation of the pathway and reduce undesirable "on-target" "off tissue" toxicities. Additionally, the inertness of the VitoKine active moiety prior to protease activation will significantly decrease the potential antigen or target sink, and thus, prolong the in vivo half-life and result in improved biodistribution, bioavailability and therapeutic efficacy.
Patent AU-2019290345-A1 (AU)
Title: Oncology treatments using zinc agents
Inventor: CHUNG JINHYUK FRED
IPC: A61K45/06
Filed: 2019-06-21
Abstract: The invention relates to methods for treating a cancer patient comprising administering a Zn(II) agent or a Zn(II) agent/immune-oncology agent combination to provide a therapeutic benefit to the cancer patient. The methods are useful in treating a broad spectrum of human cancers, including solid tumors and blood-based cancerous cells. In particular embodiments, the treatment methods are directed to cancer types characterized by genetic instability mutations.
Patent AU-2019296817-A1 (AU)
Title: Modified Y-type molecular sieve, catalytic cracking catalyst including same, and preparation and use thereof
Inventor: YUAN SHUAI
IPC: B01J35/10
Filed: 2019-06-27
Abstract: Disclosed is a modified Y-type molecular sieve having high stability, and the preparation and the use thereof. On a dry basis and using the weight of the modified Y-type molecular sieve as a reference, the modified metal content of the modified Y-type molecular sieve is approximately 0.5-6.3 wt% calculated in terms of a modified metal oxide, and the sodium content thereof is not more than approximately 0.5 wt% calculated in terms of sodium oxide, wherein the modified metal is magnesium and/or calcium. The non-skeleton aluminium percentage content of the modified Y-type molecular sieve is not higher than approximately 20% with respect to the total content of aluminum; the total pore volume thereof is approximately 0.33-0.39 mL/g, wherein the percentage of the pore volume of secondary pores with a pore diameter of 2-100 nm is approximately 10%-25% with respect to the total pore volume; the lattice constant thereof is approximately 2.440-2.455 nm; and the lattice collapsing temperature thereof is not lower than approximately 1040ºC. Moreover, the ratio of the amount of the B acid to that of the L acid in the total acid amount determined at 200ºC using a pyridine adsorption infrared method is not less than approximately 2.30. When used for the catalytic cracking of a heavy oil, the modified Y-type molecular sieve and a catalyst containing same have a lower coke selectivity, and can result in a higher gasoline yield and liquefied gas yield, and the resulting gasoline has a higher isomeric hydrocarbon content.
Patent AU-2019297199-A1 (AU)
Title: A container
Inventor: YIP ROMUALD
IPC: B65D1/32
Filed: 2019-07-03
Abstract: A container (10) having a hollow body (24) providing a space (11) to receive a liquid to be dispensed. The container (10) may also dispense granular material, pellets or powder. A valve assembly (31) of the container (10) is adapted to dispense a predetermined volume of the liquid.
Patent AU-2019297345-A1 (AU)
Title: Rupture disc having stress concentrating feature
Inventor: KREBILL MICHAEL D
IPC: F16K17/16
Filed: 2019-07-03
Abstract: A bulged, forward-acting rupture disc (10) and a pressure relief device (38) incorporating a rupture disc (10), having a line of opening (28) formed in the transition region (26) of the disc between the bulged section (12) and flange section (14) are provided. The line of opening (28) is a stress-concentrating feature that, in conjunction with a stress-intensifying edge (68) located on an associated outlet ring (42), facilitates opening of the disc (10) when exposed to a predetermined pressure acting upon the concave face (20) of the bulged section (12).
Patent AU-2019299952-A1 (AU)
Title: Selective estrogen receptor degraders
Inventor: COHEN JEFFREY DANIEL
IPC: C07D491/052
Filed: 2019-07-11
Abstract: Novel selective estrogen receptor degraders (SERDs) according to the formula: pharmaceutically acceptable salts, pharmaceutical compositions, uses, and methods of use thereof are provided.
Patent AU-2019310803-A1 (AU)
Title: Anti-TIGIT antibody and uses thereof
Inventor: SHI XINZHEN
IPC: A61K39/00
Filed: 2019-07-25
Abstract: A novel antibody and antibody fragment that specifically bind to TIGIT, and a composition comprising the antibody or the antibody fragment. A nucleic acid encoding the antibody or the antibody fragment thereof, a host cell containing same, and related uses, comprising therapeutic and diagnostic uses of the antibody and the antibody fragment.
Patent AU-2019338737-A1 (AU)
Title: Plastic oil and fat composition for bakery food dough
Inventor: AOKI RYOSUKE
IPC: A21D2/16
Filed: 2019-08-29
Abstract: The present invention relates to: a plastic oil and fat composition for bakery food dough, the composition having excellent stretchability; a method for manufacturing the said composition; a dough for a bakery food; and the bakery food, etc. The present invention also relates to a method for improving the stretchability of a plastic oil and fat composition containing food oils and fats, and a method for improving rising of a layered puffed food. This plastic oil and fat composition for a bakery food dough is characterized by containing 60-100 mass% of food oils and fat, and 0.5-20 mass% of a soybean hypocotl oil in the food oil and fat.
Patent AU-2019349863-A1 (AU)
Title: Synthetic method for the preparation of an hydrazine compound
Inventor: LI YUNZHONG
IPC: C07C241/02
Filed: 2019-09-26
Abstract: Provided is a process for preparing the compound 3 (3) or a salt or a solvate thereof, the process comprising the steps of a) Mixing the compound 4 with a mineral acid (4); b) Adding a nitrite salt or an organic nitrite derivative to the reaction mass to form a diazonium salt; c) Adding a sulfur-containing reducing agent to the reaction mass to form a hydrazyl sulfur complex, such as a hydrazyl sulfite complex; d) Hydrolysing the hydrazyl sulfur complex to provide the compound 3 or a salt or solvate thereof; and e) Optionally isolating the compound 3 or a salt or solvate thereof. Further provided is the use of the compound 3 in the synthesis of 3-[5-Amino-4- (3-Cyanobenzoyl)-Pyrazol-1-yl]-N-Cyclopropyl-4-Methylbenzamide.
Patent AU-2019375036-A1 (AU)
Title: Humanized and variant TGF-beta1 specific antibodies and methods and uses thereof
Inventor: RITTER GERD
IPC: C07K16/22
Filed: 2019-11-04
Abstract: Antibodies, particularly humanized and variant antibodies and fragments thereof, which bind to TGF-β1 are provided, recognizing human and mouse TGF-β1, particularly that preferentially bind TGF-β1, including which do not recognize or bind ΤΟΡ-β2 or ΤΟΡ-β3. Humanized and variant antibodies provided are useful in the diagnosis and treatment of conditions associated with activated or elevated TGF-β1, including cancer, and for modulating immune cells and immune response, including immune response to cancer or cancer antigens, and in fibrotic conditions. The anti-TGF-β1 antibodies, variable regions or CDR domain sequences thereof, and fragments thereof may also be used in lymphoid cell-mediated, including T cell-mediated, therapy and/or combination with chemotherapeutic s, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof. Particular antibodies are exemplified herein, including antibodies 13A1-2A, 13A1-2B, 13A1-2C, 13A1-2D, 13A1-2E, 13A1-2F, 13A1-2G, 13A1-2H, 13A1-2I, 13A1-2J, 13A1-AF, 13A1-AG, 13A1-AH, 13A1-BF, 13A1-BG, 13A1-BH, 13A1-CF, 13A1-CG, 13A1-CH, 13A1-DF, 13A1-DG, 13A1-DH, 13A1-EF, 13A1-EG and 13A1-EH.
Patent AU-2019400552-A1 (AU)
Title: Removable electric propulsion system for a rolling object, in particular a bed
Inventor: VENTURI STÉPHANE
IPC: A61G7/08
Filed: 2019-12-03
Abstract: The present invention concerns an electric propulsion system (1) for a rolling object, comprising a frame (2) having at least one motorised wheel (3), and at least one non-motorised wheel (4), a handle (6) and hitching means (5). The hitching means (5) are provided for gripping, orienting and lifting at least one wheel of the rolling load. The means for orienting the wheel of the rolling object orient the wheel in a direction perpendicular to the longitudinal direction (x) of the frame.
Patent AU-2019400961-A1 (AU)
Title: Battery electrode coatings applied by waterborne electrodeposition
Inventor: HELLRING STUART D
IPC: H01G9/00
Filed: 2019-12-17
Abstract: The present invention is directed towards a method of coating a substrate comprising electrocoating an eiectrodepositable coating composition onto the substrate, the electrodepositable coating composition comprising a binder comprising a pH-dependent rheology modifier; an electrochemically active material and/or an electrically conductive agent; and an aqueous medium. Also disclosed are electrodepositable coating compositions, coated substrates and electrical storage devices.
Patent AU-2019416028-A1 (AU)
Title: System and method against Unicode homograph attacks using Optical Character Recognition
Inventor: LOU HAIPENG
IPC: G06V30/10
Filed: 2019-12-16
Abstract: Systems and methods for Optical Character Recognition ("OCR") based anti- spoofing for Unicode homograph. The method comprises: performing operations by a computing device to make an OCR identification on an original electronic address so as to obtain an OCR electronic address; encoding (a) the original electronic address to obtain an encoded access address and (b) the OCR electronic address to obtain an encoded OCR electronic address; comparing the encoded access address to the encoded OCR electronic address; and determining if a Unicode homograph spoofing situation exists based on results of the comparing.
Patent AU-2019452180-A1 (AU)
Title: Ultrasonic system and method having improved occlusion engagement during crossing and atherectomy procedures
Inventor: SINGH ASEEM
IPC: A61B17/22
Filed: 2019-06-18
Abstract: An ultrasonic system includes an ultrasonic device having an ultrasonic transducer, and a core wire having a proximal end coupled to the ultrasonic transducer and a distal end portion that terminates at a distal tip. An ultrasonic energy source is electrically connected to the ultrasonic transducer. The ultrasonic energy source includes an ultrasonic signal generator circuit, a modulator circuit, and a controller. The ultrasonic signal generator circuit generates an ultrasonic electrical signal. The modulator circuit amplitude modulates the ultrasonic electrical signal with a macro-motion electrical signal to generate a modulated ultrasonic electrical signal. The controller executes program instructions to select between an engagement mode and a transverse mode, wherein in the engagement mode the first ultrasonic electrical signal is supplied from the ultrasonic energy source to the ultrasonic transducer and in the transverse mode the modulated ultrasonic electrical signal is supplied from the ultrasonic energy source to the ultrasonic transducer.
Patent AU-2019458403-A1 (AU)
Title: Modular fuel burner assembly
Inventor: PUTMAN SHANNON
IPC: F23D14/36
Filed: 2019-09-25
Abstract: A burner assembly having a housing with an air inlet and an air outlet. The housing is configured to guide an airflow from the air inlet and out of the housing via the air outlet. The burner assembly further includes an airflow restrictor plate for selectively restricting an amount of airflow passing out of the housing in order to reduce a heat output of the burner assembly, the airflow restrictor plate having an opening through which airflow must pass in order to exit the housing via the air outlet.
Patent AU-2019468057-A1 (AU)
Title: Terminal and communication method
Inventor: YOSHIOKA SHOHEI
IPC: H04W92/18
Filed: 2019-09-27
Abstract: The terminal has: a control unit for executing transmission of a first resource indicating a reservation; and a transmission unit for performing transmission using one or multiple resources reserved by the transmission of the first resource. The control unit adds, to control information to be transmitted through the first resource, information indicating frequency regions in which the reserved one or multiple resources are disposed.
Patent WO-2021035290-A1 (WO)
Inventor: MOSSEL BRENDA
IPC: A23L29/25
Filed: 2020-08-21
Abstract: Described herein is a method of preparing a modified gum for use in preparing a liquid thickening composition that includes treating a gum-based source material with one or more of a proline protease, a serine protease, an exopeptidase, a metalloprotease, a carbohydrase and a cysteine protease. A stable liquid composition including said modified gum and methods of using same are also provided herein.
Patent WO-2022104406-A1 (WO)
Inventor: HARRIS JAMES GORDON
IPC: C09K17/44
Filed: 2020-11-20
Abstract: L'invention concerne un procédé d'entretien d'une route non revêtue, le procédé consistant à : appliquer une composition cimentaire sur au moins une section de la route, la composition comprenant au moins 40 % en poids de ciment et au moins 5 % en poids d'une poudre dispersible comprenant un copolymère d'acétate de vinyle.
Patent AU-2020200371-A1 (AU)
Title: Controlled release, wood preserving composition with low-volatile organic content for wooden structures
Inventor: POPE THOMAS
IPC: C09D5/16
Filed: 2020-01-19
Abstract: A wood preservative composition suitable for the remedial treatment of wooden structures, such as an in-service structure such as a utility pole, railroad tie or wooden bridge. The wood preservative composition comprises a dispersion of substantially insoluble copper compound solid particles (preferably in an amount of 0.001% to 10% by weight of the composition and/or 1% to 5% copper atoms by weight of the composition), an organic biocide, an aqueous carrier and optionally a further boron compound. The composition may contain no more than 36 grams volatile organic compounds (VOCs) per liter, may be prepared such that at least 20% of all particles therein have a particle size greater than 25 microns and/or may have a viscosity from 125 to 425 tmm as measured using a penetrometer. Also disclosed is a method for the remedial treatment of said wooden structures using said composition, a method of preparing such a composition by blending.
Patent AU-2020200936-A1 (AU)
Title: Tarsal-metatarsal joint procedure utilizing compressor-distractor and instrument providing sliding surface
Inventor: TREACE JOHN T
IPC: A61B17/66
Filed: 2020-02-10
Abstract: A compressor-distractor device may be used during a surgical procedure, such as a 
surgical procedure to correct a bunion deformity. In some examples, the compressor
distractor includes first and second engagement arms having first and second pin-receiving 
holes, respectively. The first and second pin-receiving holes may be angled relative to each 
other. The compressor-distractor may also include an actuator operatively coupled to the first 
and second engagement arms. In some example uses, a clinician may pin a first surgical 
device to a patient's bones use a pair of parallel pins. After removing the surgical device over 
the parallel pins, the clinician may thread the parallel pins through the angled first and second 
pin-receiving holes of the compressor-distractor, causing the bones to move relative to each 
other. Thereafter, the clinician may actuate the actuator on the compressor-distractor to move 
the bones towards and/or away from each other.  
12097260_1 (GHMatters) P113022.AU
(33 
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Patent AU-2020203598-A1 (AU)
Title: Goggles with retaining thread of tear-off lenses
Inventor: FRANCHI AUGUSTO
IPC: A42B3/26
Filed: 2020-06-01
Abstract: It is disclosed a viewing device for off-road activities, comprising a visor (5), at least a 
package (2) of tear-off lenses (3) mountable on a lens (6) of the visor (5), and retaining means 
of the visor (5), wherein the tear-off lenses (3) have superimposable through holes (9). The 
device further comprises a retaining thread (4) reversibly associated with the visor (5) and with 
the retaining means of the visor (5), wherein the tear-off lenses (3) after being torn off are able 
to be retained by the retaining thread (4) sliding along it by means of the through holes (9).  
(Fig.1).  
12404596_1 (GHMatters) P113715.AU
11/ 
36 
1 
8 
3 
7 
912 
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7 512 
1118 
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94 
9 3 
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12 
Fig.3
Patent AU-2020203616-A1 (AU)
Title: Processes for making cyclic lipid implants for intraocular use
Inventor: CHANG JAMES N
IPC: A61K31/557
Filed: 2020-06-02
Abstract: Biocompatible implants comprising a cyclic lipid therapeutic agent are made using a low temperature melt extrusion process. The implants are suitable for intraocular use to treat an ocular condition. H:\tzm\Interwoven\NRPortb\DCC\TZM\383220_1DOC - 8/8/13
Patent AU-2020203976-A1 (AU)
Title: Combination therapy
Inventor: KOPCZYNSKI CASEY
IPC: A61K31/47
Filed: 2020-06-15
Abstract: Described herein are compounds and compositions for treating glaucoma and/or reducing 
intraocular pressure. Compositions may comprise an isoquinoline compound and a prostaglandin 
or a prostaglandin analog. Compounds described herein include those in which an isoquinoline 
compound is covalently linked to a prostaglandin or a prostaglandin analog, and those in which 
an isoquinoline compound and a prostaglandin free acid together form a salt.
1/3 
0.5% ROCKI Combinations 
-0-Travatan Z (n=5) 
0 ... -- ---------------- ---- --------
-o- Lumigan (n=6) 
2 
.............................................. -t-Xalatan (n=3) 
-23 ----- -- --- ...--------------------------.. .. .. ... .. ... .. ... .. .. ... .. ... .. ... .. .  
E EL - ..................I- -------------------------------- - ---- - --.-.
0 
-5 -------------------- --- ---. - .........-...-. ---- ------ ------- --- --------
-7 - ... .... ------ ------- - -- - ------ ---------- - ------- .... ......  
-7 . .- -- -- .. .., .... .. ..... ........ ... .  
-8 0 8 16 24 32 40 48 56 64 72 80 
time (hours) 
FIGURE 1
Patent AU-2020207408-A1 (AU)
Title: DNA monoclonal antibodies targeting PD-1 for the treatment and prevention of cancer
Inventor: WEINER DAVID B
IPC: A61K48/00
Filed: 2020-01-13
Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets programmed cell death protein 1 (PD-l). The disclosure also provides a method of preventing and/or treating disease, such as cancer, in a subject using the composition of the invention.
Patent AU-2020215043-A1 (AU)
Title: Suture management device and methods
Inventor: MACHOLD TIMOTHY R
IPC: A61B17/04
Filed: 2020-01-30
Abstract: Delivery systems, methods and associated devices for management of an elongate element having sections with differing mechanical properties, in particular, for management of a loop of suture-wire element extending proximally from a delivery catheter for deployment of a heart implant. Such management devices can include an inner feature (e.g. outward facing groove or series of tabs) along an inner circle about which a suture can be coiled and an outer feature (e.g. inward facing groove or tabs) to engage and constrain a wire section having increased stiffness within a coil having a larger diameter than the coiled suture. Such devices can be provided separately or can be integrated within a handle of the delivery catheter. Methods of loading suture-wire management devices and utilizing such devices during deployment of an implantable anchor are also described herein.
Patent AU-2020217355-A1 (AU)
Title: Novel, heavy vitamin B12 derivatives
Inventor: ANDERSON PETER
IPC: G01N33/82
Filed: 2020-08-11
Abstract: The invention discussed in this application relates to vitamin B12-based compounds 
that are useful as quantitative standards, particularly for the assessment of vitamin B12 
deficiency.
Patent AU-2020233969-A1 (AU)
Title: Aerosol provision device
Inventor: BLANDINO THOMAS PAUL
IPC: A24F40/57
Filed: 2020-03-09
Abstract: A heater arrangement for an aerosol provision device comprises a susceptor arranged to heat aerosol generating material, wherein the susceptor is heatable by penetration with a varying magnetic field, a first wire connected to the susceptor at a first position, a second wire connected to the susceptor at a second position, wherein the second position is spaced apart from the first position,andelectronic circuitry configured to determine a temperature of the susceptor at the first position based on a potential difference measured between the first wire and the second wire.
Patent AU-2020254768-A1 (AU)
Title: Low VOC multifunctional additives to improve waterborne polymer film properties
Inventor: FOSTER STEPHEN FINLEY
IPC: A61K8/891
Filed: 2020-04-03
Abstract: Low VOC multifunctional additive blends provide, in addition to coalescence, increased hardness, hardness development, scrub resistance, block resistance, dirt pickup resistance, wet adhesion, and corrosion (flash rust) resistance, among other properties, to waterborne coatings or other waterborne polymer film-forming compositions, and are comprised of known low volatile coalescents in combination with certain high volatile components some of which were not known nor heretofore utilized as coalescents. The inventive blends have been found to act synergistically to provide coalescence and unexpected improvement in properties of waterborne polymer formulations, while still providing a low VOC content to the formulations. The invention is also directed to methods for improving the properties of waterborne polymer systems and for incorporating organic acids into waterborne coatings to enhance flash rust resistance, among other properties, through use of the low VOC multifunctional additive blends of the invention.
Patent AU-2020262938-A1 (AU)
Title: Engineered microorganisms and methods for improved aldehyde dehydrogenase activity
Inventor: SHAH AMIT M
IPC: C12P7/24
Filed: 2020-04-24
Abstract: Disclosed are biosynthetic methods and engineered microorganism that enhance or improve the biosynthesis of hexamethylenediamine, caproic acid or caprolactam. The engineered microorganisms include selected aldehyde dehydrogenase activity.
Patent AU-2020274248-A1 (AU)
Title: A room temperature curable composition
Inventor: JAIN PRANSHU
IPC: C08L23/26
Filed: 2020-05-07
Abstract: The present invention discloses a room temperature curable composition, comprising: (a) a polymer; (b) a filler; and (c) a curing catalyst. The polymer is selected from the group consisting of silyl modified polyether, silyl modified polyurethane, silyl terminated polyacrylate, and combinations thereof. The composition of the present invention has sufficiently high plasticity to be moldable by hand in the uncured state.
Patent AU-2020282831-A1 (AU)
Title: Two-dimensional LC-MS/MS systems
Inventor: CHUANG WEI-LIEN
IPC: G01N30/72
Filed: 2020-05-29
Abstract: The present invention relates to a novel analytical method for detecting one or more analytes in a source sample by continuous flow 2D LC-MS/MS using a single LC system.