Patent SG-11201407490Q-A (SG)
Title: Fiber-reinforced hydrogel composites and methods of forming fiber-reinforced hydrogel composites
Inventor: ZUSSMAN EYAL
IPC: A61L27/52
Filed: 2013-05-15
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 21 November 2013 (21.11.2013) WIPOIPCT (10) International Publication Number WO 2013/172788 A1 (51) International Patent Classification: A61L 27/52 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/SG2013/000196 15 May 2013 (15.05.2013) English English (30) Priority Data: 61/647,166 15 May 2012 (15.05.2012) US (71) Applicants: TECHNION RESEARCH AND DEVEL­ OPMENT FOUNDATION LTD [IL/IL]; Senate House, Technion City, 32000 Haifa (IL). NATIONAL UNIVER­ SITY OF SINGAPORE [SG/SG]; 21 Lower Kent Ridge Road, 119077 Singapore (SG). (72) Inventors: ZUSSMAN, Eyal; 36 David Pinski, 34354 Haifa (IL). CHAGANTI, Srinivasa, Reddy; c/o Technion Israel Institute of Technology, Faculty of Mechanical En­ gineering, Technion City, 32000 Haifa (IL). VENUGO- PAL, Jayarama, Reddy; c/o National University of Singa­ pore, Nanoscience & Nanotechnology Initiative, 21 Lower Kent Ridge Road, Singapore 119077 (SG). RA- MAKRISHNA, Seeram; c/o National University of Singa­ pore, Nanoscience & Nanotechnology Initiative, 21 Lower Kent Ridge Road, Singapore 119077 (SG). REGEV, Omri; Halamish 8, 34997 Haifa (IL). (74) Agent: VIERING, JENTSCHURA & PARTNER LLP; P.O. Box 1088, Rochor Road, Singapore 911833 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). [Continued on next page] (54) Title: FIBER-REINFORCED HYDROGEL COMPOSITES AND METHODS OF FORMING FIBER-REINFORCED HY- DROGEL COMPOSITES FIG. 1 latin (ii) (iii) j;> j. .s-i'ir y I cells 00 00 l> CJ l> i-H en i-H o CJ o & (57) Abstract: A fiber-reinforced hydrogel composite is provided. The composite includes a hydrogel and a fibrous component containing a plurality of fibers. Length of each of the plur­ ality of fibers is less than about 1,000 (im. A method of preparing fiber-reinforced a hydro­ gel composite is also provided. The method in­ cludes coating a hydrogel precursor solution on a substrate to form a hydrogel precursor film, depositing the plurality of fibers onto the hydrogel precursor film, and allowing the hy­ drogel precursor film to form hydrogel a film, thereby forming the fiber-reinforced hydrogel composite. A scaffold containing the fiber-re­ inforced composite, and a tissue repair method using the fiber-reinforced composite are also provided. WO 2013/172788 A11 lllll llllllll II llllll III lllll lllll lllll III III III lllll lllll llll llll lllll lllll lllllll llll llll Published: — with international search report (Art. 21(3))