baber/WOPTO huggingface dataset:
Patent NO-178859-B (NO)
Inventor: BAADER EKKEHARD
IPC: A61P37/06
Filed: 1992-03-17
Abstract: The invention relates to mixed pyridine-2,4- and -2,5-dicarboxylic acid diamides, the carboxylic acid amide group in position 2 being a primary acid amide. The said compounds are suitable for the inhibition of proline hydroxylase and lysine hydroxylase and are used as fibrosuppressants and immunosuppressants.
Patent NO-179696-B (NO)
Inventor: EHRLICH MARIKA
IPC: A61K38/35
Filed: 1992-10-05
Abstract: An ovulation-inhibiting preparation for hormonal contraception, comprising two hormone constituents packed spatially separate in a packing unit intended for chronological, sequential oral administration, said constituents each comprising a plurality of daily hormone units accommodated spatially separate and individually removable in the packaging unit. The first hormone constituent consists essentially of an estrogen preparation which effects a disturbance of the follicle stimulation; the second hormone constituent consists of an estrogen preparation and a gestagen preparation in a dose at least adequate for inhibiting ovulation. The total number of daily hormone units is equal to the total number of days in the desired cycle, and the number of daily units of the first hormone constituent is less than the number of daily units of the second hormone constituent. The first hormone constituent comprises 5 to 14 daily units, and the second hormone constituent comprises 23 to 14 daily units.
Patent SE-310632-B (SE)
Inventor: GOLDSTEIN A
IPC: C12P17/18
Filed: 1961-05-19
Abstract: A fermented culture medium containing antimicrobial agent M-141 is obtained by cultivating the micro-organism streptomyces flavopersicus especially S. flavopersicus NRRL 2820 under submerged aerobic conditions in an aqueous culture medium containing assimilable sources of carbohydrates, nitrogen and inorganic salts, preferably at 24-32 DEG C. for a period of 1-5 days. The antimicrobial agent M-141 is recovered from the clarified culture medium in the form of its acid addition salts by adsorbtion on a cation exchange resin and elution of the adsorbate. Carboxylic and sulphonic type cation exchange resins are mentioned.  The acid addition salts of antimicrobial agent M-141 which is a nitrogenous base are characterised in that the hydrochloride of said base has the following properties:-soluble in water and methanol, but insoluble in acetone, chloroform and diethyl ether; no characteristic U.V. spectrum; an I.R. spectrum in hydrocarbon oil as shown in the drawing; [a ]25D of 25 (c=1 in water); an empirical formula C14H38O12N2C12; an elemental analysi C= 34.03%, H=7.46%, O=38.83%, N=5.56% and C1=19.1% and loss on drying of 19.1%; mol.wt. by titration of 420; Pka values of about 7.0 and 9.0 when titrated in water which change to about 5 and 7.5 when titrated in 4% aqueous formaldehyde solution and a melting point of 210 DEG C. Specified salts are the chloride and the sulphate. The hydrochloride mixed with chicken feed is used as a veterinary preparation to cure coccidioris.
Patent SE-324563-B (SE)
Inventor: FEATHER P
IPC: C07J1/00
Filed: 1966-07-01
Abstract: Novel steroids having in the 17-position the structure <FORM:1074369/C2/1> (wherein R is C1- 5 alkyl; and R1 is H, methyl, ethyl or tetrahydropyranyl) are prepared by alkylation under anhydrous conditions of a metal derivative of the corresponding 17a -butadiynyl-17b -OR1 steroids.  This process may be effected with an alkali metal derivative and an alkyl halide.  The alkali metal derivative may conveniently be formed by adding a solution of the steroid in tetrahydrofuran to the amide of the alkali metal in liquid ammonia, and when in this method a molar ratio of sodamide to a 17-hydroxy-steroid not less than about 2:1 is used the hydroxy group is alkylated as well as the butadiynyl group; while with equimolar quantities a mixture of products is obtained which can be separated by thin layer chromatography and/or fractional crystallization.  17b -tetrahydropyranyloxy products may be acid hydrolysed to the free 17b -ols, which may be alkylated.  The steroids may belong to the androstane or 19-nor-androstane (estrane) series and may optionally contain substituents and/or double bonds in the steroid nucleus, such as D 1, D 2, D 3, D 4, D 5, D 5(10), D 6, D 7, D 8, D 9, D 9(11), D 11 and D 14 double bonds, hydroxyl at positions 1, 3, 4, 5, 6 and 11, or acyloxy group, alkyl or alkenyl at positions 1, 2, 4, 6, 7 or 16, and carbonyl at positions 2, 3, 6, 11 and 12.  Hydroxy groups may be alkylated during the process unless protected as tetrahydropyranyloxy groups; acyloxy groups may be hydrolysed; and carbonyl groups may interfere with the process and are preferably protected by conversion to ketals. Products containing a D 2,5(10)-3-alkoxy grouping may be hydrolysed directly or via the D 5(10)-3-ones to the D 4-3-ones, and D 3,5-3-enol ethers may be hydrolysed to the D 4-3-ones as may D 5-3-ketals.  3b ,17b  - bis - (Tetrahydro - 21 - pyranyloxy) - 17a  - butadiynyl - androst - 5 - ene is prepared from the diol and dihydropyran.  17b -(Tetrahydro - 21 - pyranyloxy) - 17a  - butadiynyl - 4 - methyl - estra - 1,3,5(10) - triene, 17a  - butadiynyl - 3 - methoxy - 17b  - (tetrahydro - 21 - pyranyloxy) - estra - 1,3,5(10) - triene, a mixture of D 5- and D 5(10) - 17a  - butadiynyl - 17b  - (tetrahydro - 21 - pyranyloxy) - 3 - ethylenedioxy - 19 - nor-androstene (the parent 17b -ols of which are prepared from the D 4-3-one and ethyleneglycol), 17a  - butadiynyl - 17b  - (tetrahydro - 21 - pyranyloxy) - 3 - ethylenedioxy - androst - 5 - ene (the parent 17b -ol of which is prepared from the D 4-3-one and ethyleneglycol), and 17a -butadiynyl-3,17b  - bis(tetrahydro - 21 - pyranyloxy) - estra-1,3,5(10)-triene are prepared similarly.  The steroids of the invention, which may possess estrogenic, progestational, claudogenic, ovulation-inhibiting and gonadotrophin-inhibiting properties, may be administered as tablets, pills, injections or vaginal tampons.
Patent YU-47522-B (YU)
Title: Mikrokapilarni katalitički reaktorski elementi i mikrokapilarni sorpcioni elementi i postupak za njihovu proizvodnju
Inventor: MITROVIC M
Filed: 1990-10-24
Abstract: Mikrokapilarni katalitički reaktorski elementi, naznačeni time, što se sastoji od snopa mikrokapilara tankih zidova, koji su od poroznog ugljenika veoma razvijene aktivne površine i sa čvrstim katalizatorom, metal koji je elektropozitivniji od ugljenika, rasporednim u porama zidova mikrokapilara, povezanih neporoznim staklastim ugljenikom u štapove cilindričnog ili bilo kog drugog preseka. Prijava sadrži još 3 nezavisna i 4 zavisna zahteva.
Patent YU-47551-B (YU)
Inventor: SCHUETZ U
IPC: B65D77/06
Filed: 1989-11-21
Abstract: The pallet container comprises a wooden pallet or a steel pipe pallet, on which is mounted an inner container of a synthetic resin with a jacket of vertical and horizontal lattice bars (4, 5) of steel pipe, these bars forming continuous inner and outer tangential planes; (20-20, 25-25). At the points of intersection (15), the lattice bars are drawn in to form trough-like indentations. This configuration has the result that, at each point of intersection (15), four contact points (22) disposed in one plane (21-21) are produced with an accumulation of material in each case corresponding to four times the wall thickness of the lattice bars. The lattice bars (4, 5) are joined together at the points of intersection (15) in the zone of the contact points (22) by electric resistance welding. The pallet container is usable as a safely operating multiple-trip container for liquid merchandise of all kinds.
Patent ZA-801678-B (ZA)
Title: Support-arm assembly for a drill or
Inventor: MONTABERT R
IPC: E21B19/08
Filed: 1980-03-21
Abstract: A mining drill comprising a rail along which a mining drill head is slidably rectilinear, this rail being carried by a hydraulic motor pivotally connected to a rotary head at the end of an arm swingable about a pivot axis which is generally horizontal and is formed by a column or post. A first hydraulic motor is provided to rotate the post about a generally upright axis and hydraulic cylinders can be provided to swing the post about a pivot close to its pedestal. The device is designed to support the rail so that substantially parallel holes can be drilled in a subterranean structure in practically any direction, e.g. with any inclination to the axis of the main gallery, but especially parallel thereto.
Patent ZA-815269-B (ZA)
Title: Metal inlet in continuous casting apparatus
Inventor: FIGGE DIETER
IPC: B22D11/04
Filed: 1981-07-31
Abstract: 1. A metal inlet of a continuous casting apparatus, comprising a stationary fire resistant pouring body (3) partially surrounded by a mould havign walls (2) movable in the castin direction, whereby a gap (9) is provided between the facing surfaces of the mould walls and the pouring body at least at the outlet portion (4) of the latter, characterized in that the mould walls (2) have a thermally insulating layer, the gap (9) amounts to more than 0,3 mm to 2 mm and the speed of the mould walls is such that a zone (8') filled with liquid metal is present in the gap between the solidification range (8) formed from the mould walls (2) and the pouring body (3).
Patent ZA-831539-B (ZA)
Title: A method for naturally drying mineral pulps
Inventor: CARDINI JEAN LOUIS
IPC: B01D37/03
Filed: 1983-03-07
Abstract: A method of spreading a pulp for the purpose of drying it naturally, the pulp having a solid fraction which has a d80 of less than 100 microns. This method comprises the following steps: (a) adjusting the level of solids of the pulp to between 2 and 25%; (b) adding a flocculating agent to the pulp and mixing it with same, the amount of said flocculating agent being between two thirds and 98% of the optimum required for the flocculation of said pulp; and (c) spreading the mixture of pulp and flocculating agent, in the open air, in a bed the sides of which are permeable, and the bottom of which has a slope of less than 5 meters per 1000 meters, said spreading taking place 1 to 20 minutes after the adding and mixing of the flocculating agent.
Patent ZA-837416-B (ZA)
Title: Ultrasonic control of welding
Inventor: FENN ROBERT
IPC: B23K9/095
Filed: 1983-10-04
Abstract: A method of automatically controlling the production of a weld bead including examining with reflected ultrasound from one surface of a piece of material the position of a weld pool on the material and the position of another surface of the material, and controlling the position of the weld bead on the material from the result of said examination.
Patent ZA-842026-B (ZA)
Title: Pyrethroid-containing pharmaceutical compositions
Inventor: ARIAS JOSE ANTONION
IPC: A61K31/22
Filed: 1984-03-19
Abstract: Parasitic and viral diseases are treated with a pyrethroid preferably in the presence of alpha-pinene. Preferred compositions are extracts of pyrethrum with water, aqueous ethyl alcohol, or alpha-pinene.
Patent ZA-842473-B (ZA)
Title: Triaxially-braided fabric prosthesis
Inventor: SILVESTRINI THOMAS ANTHONY
IPC: A61F2/24
Filed: 1984-04-03
Abstract: A novel prosthesis for use in repairing or replacing soft tissue is disclosed, which comprises a triaxially-braided fabric element having interwoven first, second and third sets of fibers, with the fibers of the second and third sets being oriented at substantially the same acute braiding angle with respect to the fibers of the first set. An elongated ligament prosthesis exhibiting the desired properties of high strength and high elasticity may be prepared by selecting high elasticity fibers for the first set, orienting said first set of fibers in the longitudinal direction of the prosthesis and selecting fibers having high yield strength and high Young's modulus for the second and third sets. A tubular prosthesis in which high elasticity fibers are oriented in the longitudinal direction is highly suitable for use as a vascular prosthesis. A prosthesis of the invention may also be manufactured in the form of a prosthetic heart valve leaflet.
Patent ZA-865153-B (ZA)
Title: Phenyl-(3-hexamenthyleneiminopropyl)-ketone
Inventor: LAFON LOUIS
IPC: A61K31/445
Filed: 1986-07-10
Abstract: Phenyl (3-hexamethylene imino propyl) ketone (I) and its acid addn. salts are new. 4-Hexamethylene imino butyronitrile (II) is treated with phenyl magnesium bromide (III). The reaction is effected for 1 hr. at 0-25 deg.C in an anhydrous solvent, the molar ratio of (II):(III) being 1:1.
Patent ZA-866426-B (ZA)
Title: Liquid phase thermal swing chemical air separation
Inventor: ERICKSON DONALD C
IPC: B01D53/02
Filed: 1986-08-25
Abstract: A temperature swing absorption separation of oxygen from air is performed with an oxygen acceptor of alkali metal nitrate and nitrite.
Patent ZA-882123-B (ZA)
Title: Flotation mechanism
Inventor: KRISHNASWAMY PREM
IPC: B03D1/20
Filed: 1988-03-24
Abstract: A flotation cell for recovery of minerals from ore using a three phase system flotation process provides improved metallurgical recovery through improved pump rotor/stator 24, 26 and cell design by establishing good zonal separation within the cell and minimizing froth turbulence, providing uniform aeration in the cell, and accommodating higher aeration volumes before encountering turbulence. Parameters for the rotor/stator pump assembly 22, a deflector vane 36 forming part of the stator, and for the pump assembly/cell configuration are disclosed.
Patent ZA-886907-B (ZA)
Title: Superconducting materials and process for their preparation
Inventor: LAFON MARIE-ODILE
IPC: C01G3/00
Filed: 1988-09-16
Abstract: Method of preparing a superconductive fine powder essentially based on at least one rare earth, at least one alkaline-earth element, at least one transition metal and oxygen, characterised in that it comprises the following stages:
 a) an aqueous solution is prepared based on nitrates and/or acetates of at least one rare earth, at least one alkaline-earth element and at least one transition metal;
 b) the said solution is spray-dried
 c) the dried product is calcined
 d) grinding of the calcined powder is optionally carried out. 
<??>The invention also relates to the products obtained by the said method.
Patent ZA-889023-B (ZA)
Title: 2-(piperazinyl)-2-oxoethylene substituted flavonoid derivatives,processes for preparing them and pharmaceutical compositions containing them
Inventor: ROLLAND YVES
IPC: A61K31/495
Filed: 1988-12-01
Abstract: Compound of general formula I:   <IMAGE> (I)  in which: A is a single or double bond, R1 and R3, which may be identical or different, are each a hydrogen atom, an alkoxycarbonylmethylene radical of formula -CH2CO2R4 (in which R4 denotes an alkyl radical having 1 to 5 carbon atoms) or a radical of formula W:  <IMAGE>  (in which n is equal to 0 or 1 and R5, R6 and R7, which may be identical or different, are each a hydrogen or halogen atom, a hydroxyl radical, a trifluoromethyl radical, a lower alkyl radical containing 1 to 5 carbon atoms or an alkoxy radical containing 1 to 5 carbon atoms), R2 is a hydrogen atom, an alkoxycarbonylmethylene radical of formula -CH2CO2R4, a radical of formula W, or a  beta -glucose or rutinose molecule linked to the oxygen to which it is attached with a glycoside bond, on condition, however, that at least either R1 or R2 or R3 always denotes a radical of formula W, and their addition salts with a pharmaceutically acceptable inorganic or organic acid.
Patent ZA-902879-B (ZA)
Title: Unsaturated derivatives of 2,6-amino-heptanedioic acid,their preparation process and their application as medicaments
Inventor: AGOURIDAS CONSTANTIN
IPC: A61K31/16
Filed: 1990-04-17
Abstract: Novel derivatives of formula <IMAGE>  in which,  - the dotted lines represent an optional endo or exo double bond, - Y represents a (C2-18) alkyl, alkenyl or alkynyl or a (C1-18) alkyl substituted by one or several halogens, - X, X' and X1 represent hydrogen, an (-> C8) alkyl, alkenyl or alkynyl, an (-> C14) aryl, an (-> C18) aralkyl or an acyl derived from a fatty acid and/or an amino acid, and either n and/or n1 represents 1 and R and/or R1 represents an amino radical or an amino acid radical, or n and/or n1 represent 2 and R and R1 represent hydrogen, an (C1-8) alkyl or an (-> C14) aryl or an (-> C18) arylalkyl or a <IMAGE> radical,  in which R2 represents a (C1-8) alkyl or an (-> C14) aryl, as well as their salts with acids or bases, a process for their preparation, their application as drugs and the compositions containing them.
Patent ZA-904993-B (ZA)
Title: Melamine-containing photoresists of improved sensitivity
Inventor: GRAZIANO KAREN ANN
IPC: G03F7/004
Filed: 1990-06-27
Abstract: Melamine-containing photoresists are disclosed that display increased sensitivity, measured as lithographic potential, when compared to known photoresists that contain melamine resin as a crosslinker. The melamine resin in these photoresists contains a higher percent, by weight, of monomeric hexamethoxymethylmelamine than in known resists.
Patent ZA-909369-B (ZA)
Title: New isoindolone derivatives,their preparation and the pharmaceutical compositions containing them
Inventor: DUBROEUCQ MARIE-CHRISTINE
IPC: C07D401/06
Filed: 1990-11-22
Abstract: New isoindolone derivatives of general formula (I) in which the radicals R are hydrogen atoms or, together, form a bond, the symbols R' are phenyl radicals which may be substituted with a halogen atom or a methyl radical at position 2 or 3, X is an oxygen or sulphur atom or a radical N-R3, R3 being H, alkyl, optionally substituted, or dialkylamino, R1 is phenyl, optionally substituted, cyclohexadienyl, naphthyl or heterocyclic, R2 is H, halogen, OH, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkyloxy, alkylthio, acyloxy, carboxy, alkyloxycarbonyl, optionally substituted, benzyloxycarbonyl, amino or acylamino, in their (3aR,7aR) forms or in the (3aRS,7aRS) form or mixtures thereof, where appropriate their salts where they exist and their preparation. 
<??>The new derivatives according to the invention are especially advantageous as substance P antagonists. 
<IMAGE>
Patent ZA-937077-B (ZA)
Title: 5-oxo-dibenzo(a,d)cyclohepta-1,4-dienes
Inventor: WILD HANNO
IPC: C07C317/44
Filed: 1993-09-24
Abstract: The invention relates to substituted 5-oxodibenzo[a,d]cyclohepta-1,4-dienes of the general formula (I) <IMAGE> having the meaning of the substituents indicated in the description, processes for their preparation and their use as retroviral agents.
Patent ZA-943210-B (ZA)
Title: A cathode for the electrolytic deposition of non-ferrous metals
Inventor: SITGES MENENDEZ FRANCISCO JAVIER
IPC: C25C7/02
Filed: 1994-05-09
Abstract: A cathode for the electrolytic deposition of non-ferrous metals, consisting of a plate (1) which, starting from one at least one of its vertical edges, is provided on both sides with coinciding zones (5) of dielectric material situated at the height of impingement of a number of penetrators which cause the upper edge of the deposited layers of zinc to detach. The plate (1) is provided with a slot (7), coinciding with said regions of dielectric material, which is occupied by a flat piece (5) of dielectric material, equal in thickness to the plate (1) and with surfaces which are flat and coplanar with those of said plate (1). The piece (5) and the slot (7) are provided with means of preventing the movement of said piece in any direction. <IMAGE>   <IMAGE>
Patent ZA-976142-B (ZA)
Title: Method for treating and preventing neurodegenerative disorders.
Inventor: CARROLL RICHARD THOMAS
IPC: A61K31/426
Filed: 1997-07-10
Abstract: PCT No. PCT/US97/11586 Sec. 371 Date Oct. 28, 1998 Sec. 102(e) Date Oct. 28, 1998 PCT Filed Jul. 1, 1997 PCT Pub. No. WO98/02160 PCT Pub. Date Jan. 22, 1998Neurodegenerative disorders, i.e., Alzheimer's disease, stroke, multiple sclerosis and head trauma are treated with 5-[[{3,5-bis(1,1,-dimethylethyl)-4-hydroxyphenyl]methylene]-2-imino-4-thiazolidinone or a pharmaceutically acceptable salt thereof.
Patent ZA-978325-B (ZA)
Title: Assembly of container and break-off closure and method of producing it
Inventor: BEKKERS HENRICUS ANTONIUS MARI
IPC: A61M5/30
Filed: 1997-09-16
Abstract: An assembly is provided comprising a container and a break-off closure made of plastic. The container comprises a surface with a passage opening, which opening is sealed by the break-off closure An attachment area is provided between the break-off closure and the surface of the container, which area is situated around and at a distance from the circumference of the passage opening. The attachment being obtained by heating the attachment surface of one of the container and break-off closure to such a temperature that a breakable attachment is formed between them.
Patent ZA-989356-B (ZA)
Title: Pharmaceutical preparations
Inventor: KUNTZE ULRICH GUENTHER ULRIKE
IPC: A61K31/04
Filed: 1998-10-14
Abstract: The invention relates to new, in particular orally administered pharmaceutical preparations containing, as pharmaceutical agent, pentaerythritol tetranitrate (PETN) or its metabolites pentaerythritol trinitrate, pentaerythritol dinatrate and pentaerythrito mononitrate, in amounts which guarantee the patient a sufficient dosage with one administering (per day).
Patent GB-2367125-B (GB)
Title: Method of and apparatus for investigating tissue histology
Inventor: CANE MICHAEL ROGER
IPC: A61B5/00
Filed: 2000-06-01
Granted: 2004-07-14
Abstract: Apparatus for monitoring the presence of one or more chromophores in a tissue sample, apparatus comprises a light source for projecting light to illuminate an area of such tissue sample, a photo-receptor for receiving light re-emitted by the illuminated area of tissue, and spectroscopic analyser means for monitoring the remitted light, a comparator having means for comparing variations in the intensity and spectral characteristics of the remitted light with respect to the intensity and spectral characteristics of the projected light at different wavelengths and with a record of the intensity and spectral characteristics of light remitted by a reference sample of such tissue and means for emitting a control signal in response to any such variations.
Patent GB-2393644-B (GB)
Title: Bottle rack
Inventor: SAUNDERS CARL ARTHUR
IPC: F16B12/42
Filed: 2002-08-15
Granted: 2005-07-06
Abstract: The "self-assembly" bottle rack consists of a number of metal strips (1) adapted to be arranged into an orthogonal grid with, at each intersection of the grid one of a plurality of elongate support support members, each connected to the strips. One end of each support member (5) has two orthogonal slots (7). Each slot (7) is wider at its mouth than it is at an inner end. Each slot (7) thus has a relatively wide guide portion at the outer end of the slot and a narrower gripping portion at an inner end do hold the strips in the orthogonal arrangement. The support members (5) extend substantially perpendicularly to the plane of the grid. <IMAGE>