Patent SG-11201907496R-A (SG)
Title: Cyclic di-nucleotides compounds for the treatment of cancer
Inventor: KIM DAE-SHIK
IPC: C07H19/213
Filed: 2018-02-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 23 August 2018 (23.08.2018) WIPO I PCT Hu omit VIII °nolo OH lit mil loollowo oimIE (10) International Publication Number WO 2018/152450 Al (51) International Patent Classification: A61P 31/04 (2006.01) CO7F 9/6574 (2006.01) A61K 31/7084 (2006.01) C07H 19/213 (2006.01) CO7F 9/6527 (2006.01) A61P 37/04 (2006.01) (21) International Application Number: PCT/US2018/018556 (22) International Filing Date: TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) (25) Filing Language: (26) Publication Language: (30) Priority Data: 17 February 2018 (17.02.2018) English English Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) 62/460,562 17 February 2017 (17.02.2017) US 62/479,169 30 March 2017 (30.03.2017) US 62/551,645 29 August 2017 (29.08.2017) US 62/551,647 29 August 2017 (29.08.2017) US 62/551,668 29 August 2017 (29.08.2017) US (71) Applicant: EISAI R&D MANAGEMENT CO., LTD. [JP/JP]; 6-10, Koishikawa 4-Chome Bunkyo-ku, Tokyo, 112-8088 (JP). (72) Inventors: KIM, Dae-Shik; 79 Dascomb Road, Andover, Massachusetts 01810 (US). FANG, Frank; 16 Greybirch Road, Andover, Massachusetts 01810 (US). ENDO, At- sushi; 311 Lowell Street, Andover, Massachusetts 01810 (US). CHOI, Hyeong-Wook; 39 Juniper Road, Andover, Massachusetts 01810 (US). HAO, Ming-Hong; 138 Quin- cy Shore Drive, #173, Quincy, Massachusetts 02171 (US). BAO, Xingfeng; 993 Main Street, Concord, Massachusetts 01742 (US). HUANG, Kuan-Chun; 7 Manning Street, Lexington, Massachusetts 02421 (US). (74) Agent: WALTERS, Todd R. et al.; BUCHANAN INGERSOLL & ROONEY PC, P. 0. Box 1404, Alexan- dria, Virginia 22313-1404 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 00 1-1 (54) Title: CYCLIC DI-NUCLEOTIDES COMPOUNDS FOR THE TREATMENT OF CANCER C (57) : Provided herein are compounds useful for the treatment of cancer. O