Patent RU-2194699-C2 (RU)
Title: 1-phenylbenzimidazole compounds, pharmaceutical composition and method of treatment of disorder or diseases sensitive to modulation of aminobutyric acid heteropentameric complex (abahpc)-receptor complex of central nervous system
Inventor: TEUBER LENE
IPC: A61K31/4523
Filed: 1997-10-21
Granted: 2002-12-20
Abstract: FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel benzimidazole compounds presented by the general formula (I):   where o means number 0, 1, 2 or 3; R 1  means alkyl group, phenyl group or monocyclic heterocyclic group comprising N or O as heteroatom being these groups can be substituted once or more times with substitutes taken among alkyl, cycloalkyl, cycloalkylalkyl, alkoxy-, cyano-, amino- and nitro-group; or R 1  means cyano-group or group of the formula alkyl-CO 2 R 2 , alkenyl-CO 2 R 2 , -CO-R 2 , -  or -C(R 3 )=N-OR 2  where m means number 0, 1, 2 or 3; R 2  means hydrogen atom, alkyl, phenyl, benzyl, 5- or 6-membered heterocyclic group being this 5- or 6-membered group can be substituted possibly with once or more times with alkyl or alkoxy-group; or R 2  can means group of the formula   or alkyl-CO 2 R 4  where R 4  and R 5  mean independently hydrogen atom or alkyl, and q means number 0, 1, 2 or 3; R 3  means hydrogen atom or alkyl; R 11  means group of the general formula   where R 9  means alkyl; or R 9  can mean 6-membered heterocyclic group being this 6-membered heterocyclic group can be possibly substituted once or more times with alkyl or alkoxy-group; or R 9  means group of the general formula -alkyl-N(R 10 R 12 ) where R 10  and R 12  mean independently hydrogen atom or alkyl; or R 11  means group of the general formula (II):   where n means number 0, 1, 2 or 3; R′ and R″ in common with N atom to which they are bound form heterocyclic ring with members number from 5 to 7 being this heterocyclic ring can comprise possibly one oxygen atom and/or additional nitrogen atom as a member of ring; also in this formula heterocyclic ring with members number from 5 to 7 formed by R′ and R″ can be possibly substituted once or more times with group of the formula   where p means number 0, 1, 2 or 3; X means hydrogen atom, hydroxyl, alkyl or alkenyl being these alkyl and alkenyl can be possibly substituted one or more times with group of the formula  ; or X means group of the formula   or -CON-R 6 R 7  being in these formulas R 6  and R 7  mean independently hydrogen atom or alkyl; or R 11  can mean group of the general formula (III):   where n means number 1; R′ means hydrogen atom or alkyl; R′′′ and R′′′′ in common with atoms to which they are bound form heterocyclic ring with members number from 5 to 7 being this heterocyclic ring can possibly comprise a single chain -CH=CH- as a member ring; also, in this formula heterocyclic ring with members number from 5 to 7 formed by R′′′ and R′′′′ can be possibly substituted once or more times with group of the formula   where p means number 0, 1, 2 or 3; X means hydrogen atom, alkyl; or its pharmaceutically acceptable salt under condition that if R 11  means morpholinyl then R 1  can't mean tert.-butyl. Invention relates also to pharmaceutical composition showing properties of modulator of ABAHPC-receptors and to method of treatment of disorders and diseases of live body being this disorder or disease is sensitive to modulation of ABAHPC- receptor complex of the central nervous system. EFFECT: improved method of treatment, valuable medicinal properties of compounds. 14 cl, 7 tbl, 38 ex