baber/WOPTO huggingface dataset:
Patent CA-2968736-A1 (CA)
Inventor: SACHS LARS NORMAN
IPC: C12N5/071
Filed: 2015-11-27
Abstract: TECHNICAL FIELD The invention is in the field of epithelial stem cell culture media and methods, in particular culture media and methods for expanding populations of epithelial stem cells, e.g. human epithelial stem cells. BACKGROUND There is great interest in culture media and methods for expanding populations of stem cells. Populations of stem cells have many uses. For example, stem cells and their differentiated progeny can be used in cellular assays, drug screening, and toxicity assays. Stem cells also show promise for cell-based therapies, such as in regenerative medicine for the treatment of damaged tissue. Furthermore, efficient cell culture media are important for providing and maintaining populations of cells for research purposes. Methods for the long-term culture of epithelial stem cells or tissue fragments derived from several tissues (e.g. pancreas, colon, intestinal crypts, stomach, liver and prostate) have been described (see WO 2010/090513, WO2012/014076 and WO2012/168930). There is a need for improved culture media and methods that result in a higher efficiency of successful organoid formation. SUMMARY OF THE INVENTION The invention provides a method for expanding epithelial stem cells comprising: providing a population of epithelial stem cells; providing a culture medium comprising an ErbB3/4 ligand, a receptor tyrosine kinase ligand and a BMP inhibitor; contacting the stem cells with the culture medium; and culturing the cells under appropriate conditions. The invention further provides a culture medium comprising a receptor tyrosine kinase ligand and a BMP inhibitor, characterised in that the culture medium further comprises an ErbB3/4 ligand. The invention further provides an organoid that is obtained or obtainable from a method of the invention.
Patent CA-2971903-A1 (CA)
Inventor: MATAN STEFAN
IPC: H02J3/18
Filed: 2010-02-19
Abstract: A power transfer system provides power factor conditioning of the generated power. Power is received from a local power source, converted to usable AC power, and the power factor is conditioned to a desired value. The desired value may be a power factor at or near unity, or the desired power factor may be in response to conditions of the power grid, a tariff established, and/or determinations made remotely to the local power source. Many sources and power transfer systems can be put together and controlled as a power source farm to deliver power to the grid having a specific power factor characteristic. The farm may be a grouping of multiple local customer premises. AC power can also be conditioned prior to use by an AC to DC power supply for more efficient DC power conversion.
Patent CA-2974176-A1 (CA)
Inventor: FLOROS MICHAEL C
IPC: C07C67/02
Filed: 2016-01-11
Abstract: A method of producing a diol diester, which includes reacting a fatty acid alkyl ester having 6 to 30 carbon atoms, an a,?-alkanediol having n carbon atoms, wherein n is an integer from 2 to 22; and a basic transesterification catalyst, is provided. Use of the diol diesters as phase change materials is also provided. In preferred embodiments, the basic transesterification catalyst is an inorganic base, such as an alkali metal hydroxide, an alkali metal alkoxide, or an alkali metal carbonate.
Patent CA-2975580-A1 (CA)
Inventor: IWAMOTO TATSUYA
IPC: B32B7/02
Filed: 2016-02-05
Abstract: Provided is a laminated-glass interlayer that enables the thickness of laminated glass to be controlled with high accuracy. This laminated-glass interlayer has an MD direction and a TD direction. The interlayer, with the dimensions thereof in the MD direction being X, is heated for ten minutes at 110ºC, and the heated interlayer is stretched so that the MD-direction dimensions become 1.2X. In that stretched state, the interlayer is secured using a securing tool, and the secured interlayer is immersed in 0ºC water for one minute. The interlayer is removed from the 0ºC water, the securing tool is detached from the interlayer, and then the detached interlayer is stored for ten hours at 23ºC and a relative humidity (RH) of 30%. When the MD-direction dimensions of the interlayer, after such storage, are measured, the MD-direction dimensions of the interlayer post-storage are at least 1.05X.
Patent CA-2976189-A1 (CA)
Inventor: CLOUTIER JEAN-LOUIS
IPC: E03C1/122
Filed: 2017-08-11
Abstract: A plumbing apparatus for connecting a tail piece to a waste pipe is provided. The apparatus comprises a body having a top flanged end including an inlet configured for receiving the tail piece, a bottom end having an outlet for receiving the waste pipe, and a channel extending between the inlet and outlet. A seal extends about the channel for forming a watertight seal between the tail piece and the waste pipe. A plate is secured to the top flanged end for securing the apparatus to the floor above the waste pipe, may be removable to facilitate post-installation maintenance, and may have an off-center opening to fit various waste pipe configurations. The apparatus is useful for installing plumbing fixtures such as bathtubs, particularly where there is no access from underneath such as in already built homes.
Patent CA-2976333-A1 (CA)
Inventor: SMITS AARON
IPC: A61B17/82
Filed: 2015-02-13
Abstract: An apparatus (10) for the correction of chest deformities is provided and includes a rib implant (26) for mounting to a rib, a sternal implant (22) for mounting to a sternum, and a first elongate member (24). The rib implant includes a first aperture (44) having a first axis (45). The sternal implant includes a second aperture (140) having a second axis (143). The first elongate member has a first end (152) adjustably received in the first aperture and a second end (150) adjustably received in the second aperture.
Patent CA-2978399-A1 (CA)
Title: Anti-human membrane-type adam28 antibody
Inventor: MIYAKOSHI AKIRA
IPC: C12P21/08
Filed: 2016-03-04
Abstract: The present invention provides an antibody which has an activity of binding specifically to human membrane-type ADAM28 at an epitope present in a domain lying between amino acid residue 524 and amino acid residue 659 in the amino acid sequence represented by SEQ ID NO: 2. The present invention also provides a drug delivery medium for delivering a drug to a cell or tissue in which human membrane-type ADAM28 can be expressed, said drug delivery medium comprising the antibody.
Patent CA-2978899-A1 (CA)
Inventor: FREEMAN STEPHANIE A
IPC: B01D53/62
Filed: 2016-01-29
Abstract: La présente invention concerne un procédé comprenant les étapes consistant à faire passer un fluide dans un contacteur à co-courant, à faire passer un solvant dans le contacteur à co-courant, à diviser le solvant en gouttelettes de solvant ayant une première taille de gouttelette moyenne, à placer le fluide en contact avec les gouttelettes de solvant pour créer un flux combiné, à réaliser la coalescence d'au moins une partie des gouttelettes de solvant pour créer des gouttelettes de solvant ayant une seconde taille de gouttelette moyenne, la seconde taille de gouttelette moyenne étant supérieure à la première taille de gouttelette moyenne, et à séparer le fluide et le solvant.
Patent CA-2980553-A1 (CA)
Inventor: SMITH MATTHEW
IPC: H01F27/04
Filed: 2015-03-31
Abstract: The invention concerns a top head housing (12) for a current transformer (10), which is to be mounted on top of an insulating column (16) of the current transformer, and forming a chamber for windings (14) of the current transformer (10), said top head housing (12) being made of two parts (20) fixed one to the other, and comprising two openings (18) through each of which a conductor penetrates the chamber, said openings (18) being symmetrically opposed with reference to a main vertical axis (A) of the top head housing (12), characterized in that the two parts (20) of the top head housing (12) consist of two half shells (20) comprising identical bodies (24).
Patent CA-2983214-A1 (CA)
Title: Treatment of bacterial infections in aquaculture
Inventor: MATTEY MICHAEL
IPC: A61P31/04
Filed: 2016-04-20
Abstract: A composition comprises bacteriophage covalently attached to an edible particle and is for use in treating bacterial infection in fish or crustaceans. Infections in fish or crustaceans caused by Vibrio, Aeromonas, Yersinia, Moritella, Rickettsia, Piscirickettsia, Lactococcus, Pseudomonas, Flavobacterium or Photobacterium bacteria species can be treated. Bacteria infected with a lysogenic bacteriophage are used for treating disease of fish or crustaceans caused by similar infections by bacteria carrying lysogenic bacteriophage that express a toxin gene.
Patent CA-2985782-A1 (CA)
Inventor: GOLDWITZ BRIAN
IPC: B60R5/04
Filed: 2017-11-17
Abstract: Security devices include a side panel movably coupled to an attachment mechanism and to a top panel. At least one extension structure may be configured to adjust laterally inward and outward relative to the top panel. A locking mechanism may be positioned to lock the at least one extension structure from being adjusted laterally when in the secured position. The side panel is positioned at least substantially transverse to the top panel with the at least one extension structure extending laterally outward from the top panel when in a secured position, and at least substantially parallel to the top panel with the at least one extension structure positioned laterally inward when in a storage position. Other aspects, embodiments, and features are also included.
Patent CA-2988252-A1 (CA)
Inventor: SMELTZER MARK S
IPC: A01N37/18
Filed: 2016-06-02
Abstract: A composition and methods for the non-invasive destruction of bacteria cells in vivo using a combination therapy of antibiotics and photothermal nano-theranostics. In one aspect, a composition and method for destroying at least one bacteria cell using a functionalized PA contrast agent with a targeting agent, coating, and antibiotic that uses photoacoustic signals to create thermal energy and release the loaded antibiotic are described.
Patent CA-2989447-A1 (CA)
Title: Plateforme de pari collaborative
Inventor: DEGUARA DAMIAN
IPC: G06Q50/34
Filed: 2016-06-16
Abstract: L'invention concerne une plateforme de pari collaborative qui est structurée autour d'un serveur (1) en communication avec des dispositifs de client (4) par l'intermédiaire de l'Internet (3), le serveur (1) étant configuré afin de faciliter des transactions de pari électronique spécifiques, et, plus particulièrement, permettant à des sélections de pari électronique enregistrées par des parieurs primaires (110) d'être traitées de manière conditionnelle au nom de parieurs secondaires (120). Une telle facilitation de sélections de pari électronique est éventuelle lors de l'enregistrement d'une note de crédit par rapport à un compte d'un parieur secondaire (120), qui a l'effet de réservation de fonds dans le compte du parieur secondaire (120). Le montant de la note de crédit est représentatif d'un montant de mise minimal qu'il est demandé au parieur secondaire (120) de s'engager à miser par acceptation d'une contre-offre de pari initial basée sur une sélection de pari enregistrée par un parieur primaire (110).
Patent CA-2991087-A1 (CA)
Title: Radiation carrier and use thereof in an optical sensor
Inventor: VERCRUYSSE DRIES
IPC: G01N15/10
Filed: 2016-06-30
Abstract: A radiation carrier (100) for carrying at least a radiation beam (103) has, on a surface (102) thereof, at least one excitation grating (101), for directing at least an excitation radiation beam (104) directionally out of the radiation carrier, thereby illuminating a region of interest (105); and at least one structure (108) for redirecting emission radiation emanating from the region of interest. Further a sensor is provided comprising at least one such radiation carrier (100) and at least one detector, the structure (108) being adapted for redirecting radiation from the region of interest (105) into the at least one detector (110).
Patent CA-2992205-A1 (CA)
Title: Use of african seed extract for hunger suppression
Inventor: EPNER PAUL
IPC: A61K36/185
Filed: 2018-01-17
Abstract: A composition and method for the use of Irvingia gabanensis seed extract for hunger suppression in obese individuals with low Leptin sensitivity, individuals with higher levels of ghrelin, and for individuals with Cannabis-induced appetite stimulation where dosage can be effectively administered in a gum base cold pressed into a tablet containing at least 100 mg of Irvingia gabonensis seed extract and Maltitol, Sorbitol, lsomalt, Xylitol, natural & artificial flavors, vegetarian magnesium stearate, Sucralose and Silicon dioxide.
Patent CA-2994182-A1 (CA)
Title: Parcmetre leger resistant au vandalisme
Inventor: MACKAY GEORGE ALLAN
IPC: G07C1/30
Filed: 2016-08-08
Abstract: L'invention concerne un parcmètre qui peut comporter un boîtier constitué au moins sensiblement d'un matériau résistant aux chocs. En particulier, le matériau résistant aux chocs peut comprendre un matériau parmi un copolymère de polycarbonate ou une résine mélangée de polycarbonate, un copolymère à base de nylon, ou un polymère à base de nylon qui comprend des fibres de verre ou fibres de Kevlar longues. Le boîtier renferme les composants du parcmètre pour assurer la protection des composants du parcmètre contre un environnement externe et des attaques de vandalisme.
Patent CA-2997317-A1 (CA)
Inventor: HULL KATHERINE LEIGH
IPC: E21B43/27
Filed: 2016-09-01
Abstract: Provided in this disclosure, in part, are methods, compositions, and systems for degrading organic matter, such as kerogen, in a subterranean formation. Further, these methods, compositions, and systems allow for increased hydraulic fracturing efficiencies in subterranean formations, such as unconventional rock reservoirs. Also provided in this disclosure is a method of treating kerogen in a subterranean formation including placing in the subterranean formation a composition that includes a first oxidizer including a persulfate and a second oxidizer including a bromate.
Patent CA-2998246-A1 (CA)
Title: Turbine assembly with auxiliary wheel
Inventor: SNYDER BRANDON R
IPC: F02C9/28
Filed: 2018-03-16
Abstract: Various embodiments of the present application provide one or more of; (1) auxiliary wheel that (a) enables accurate speed detection of a turbine disc and/or (b) presents a machining surface for balance correction; and/or (2) techniques for mounting an auxiliary wheel to a rotor, such as a turbine disc.
Patent CA-2999104-A1 (CA)
Inventor: UNTERSCHUTZ THOMAS
IPC: G06F21/62
Filed: 2016-09-12
Abstract: The invention relates to a method (100) and to a system for the protection of electronic data. The method (100) comprises the following steps: determining (101) data of the electronic data that can be associated with a person; concealing (103) the data of the electronic data that can be associated with a person by means of a first cryptographic key; storing (105) the electronic data with the data concealed by the first cryptographic key; and in the event that the first cryptographic key can no longer be considered secure, concealing (107) the data concealed by the first cryptographic key by means of a second cryptographic key.
Patent CA-3000315-A1 (CA)
Inventor: GADSDEN LOPEZ CARLOS
IPC: E04C2/34
Filed: 2016-09-27
Abstract: The invention relates to a construction system based on spatial cells, which consists in joining at least two structural elements or hollow sheet cells having a modified hyperboloid shape and comprising covers on the upper and lower parts thereof. The butt-joining of the sheet cells by the upper and lower ends thereof creates a structural system with the capacity to absorb and transmit forces in all directions, thereby obtaining a light and resistant structure.
Patent CA-3001621-A1 (CA)
Inventor: LEI MING
IPC: B01D15/38
Filed: 2016-10-31
Abstract: The present disclosure provides, in one aspect, a device and a method for unit sequencing and/or analysis of a molecular sequence comprising attaching the molecular sequence to a plate and controlling the progression of the molecular sequence through a pore of a nanopore chip, wherein the separation distance between the nanopore chip and the scan plate is controlled by a precision mechanical drive, and the molecular sequence is sensed as it progresses through the nanopore.
Patent CA-3003254-A1 (CA)
Title: Vacuum packaging device
Inventor: KIM KUM-JA
IPC: B65B31/02
Filed: 2016-10-26
Abstract: A vacuum packaging device according to the present invention comprises: a vacuum packaging unit for vacuum-packaging a packaging sheet; and a cutting unit provided on the vacuum packaging unit so as to form a notch for tearing on the packaging sheet.
Patent CA-3004739-A1 (CA)
Title: Carte a microprocesseur de dossier medical personnel multi-applications
Inventor: FREEDMAN ALIX MICHAEL
IPC: G06Q50/22
Filed: 2016-03-10
Abstract: L'invention concerne une carte de dossier médical personnel permettant de mémoriser des informations médicales instantanément accessibles se rapportant à l'individu associé à la carte de dossier médical personnel. Le dispositif mémoire destiné à mémoriser des informations médicales personnelles d'un individu comprend : une mémoire qui mémorise des données lisibles par ordinateur, ladite mémoire mémorisant : une section d'informations primaires comprenant des informations qui identifient l'individu associé au dispositif mémoire et des informations de base se rapportant à l'identité de l'individu, les informations primaires étant accessibles par un lecteur de dispositif mémoire sans aucune authentification ; une section d'informations secondaires comprenant un premier niveau d'informations médicales sensibles et confidentielles de l'individu, ladite section d'informations secondaires n'étant accessible que par le lecteur de dispositif mémoire après authentification ; et, éventuellement, une section d'informations tertiaires comprenant un second niveau des informations médicales sensibles et confidentielles de l'individu, ladite section d'informations tertiaires n'étant accessible que par le lecteur de dispositif mémoire après un second niveau d'authentification.
Patent CA-3008821-A1 (CA)
Inventor: ALLETTO EUGENE
IPC: A47C31/00
Filed: 2016-12-08
Abstract: A pillow (10) is provided that includes a back section (12) having opposite front and back surfaces (14) that each extend between opposite top and bottom surfaces (18, 52C). The surfaces (14) each extend between opposite first and second side surfaces (22, 52E). The pillow (10) includes spaced apart first and second arms (26) that each extend outwardly from the front surface (14). The first arm (26) has an inner surface (26A, 28A) and an opposite outer surface (26B, 28B) that is continuous with the first side surface (22). The second arm (28) has an inner surface (26A, 28A) and an opposite outer surface (26B, 28B) that is continuous with the second side surface (24, 52F). The inner surfaces (26A) are continuous with the front surface (14). The top surface (18, 52C) and the side surfaces (22) each include a first portion (30A, 30B, 30) comprising a first material and a second portion (32) comprising a second material that is different from the first material.
Patent CA-3010026-A1 (CA)
Title: Packaging system comprising a plurality of sub units, and a sub unit
Inventor: KNUTSEN STIAN VALENTIN
IPC: B65D69/00
Filed: 2016-12-23
Abstract: The invention relates to a sub unit (200) and a packaging system (100) comprising a plurality of sub units (200). The sub unit (200) is formed with a tapered body (300) having sidewalls (304) towards a narrow end (307, 308) from a first opposing or outer surface (204) at an end opposite the narrow end. The packaging system (100) comprises a plurality of sub units (200), where the sub units (200) are configured to be positioned so that the first opposing surfaces form an outside of the packaging system.
Patent CA-3010607-A1 (CA)
Title: Elimination de gaz de combustion a partir de fumees au moyen de matiere minerale derivee de charbon
Inventor: SWENSEN JAMES S
IPC: B01D53/60
Filed: 2017-01-06
Abstract: Selon la présente invention, une matière minérale dérivée de charbon capture ou élimine les émissions de gaz de combustion dans des fumées. La matière minérale dérivée de charbon peut être obtenue par séparation de celle-ci à partir des particules de charbon, par exemple au moyen d'un procédé de séparation par flottation. La matière minérale dérivée de charbon peut également être présente dans des déchets de charbon fins. Dans le procédé de l'invention, une suspension aqueuse de particules de matière minérale dérivée de charbon est mise en contact avec les émissions de gaz de combustion pendant un temps suffisant pour amener les émissions de gaz de combustion à réagir avec la suspension aqueuse et former une suspension aqueuse améliorée. Les émissions de gaz de combustion peuvent comprendre NOx, SOx, CO, ou des mélanges de ceux-ci. Une suspension aqueuse de particules de matière minérale dérivée de charbon contenant des quantités augmentées de composés insolubles de réaction de sulfate, sulfite, nitrate, nitrite, ou carbonate formés par réaction de la suspension aqueuse des particules de matière minérale dérivée de charbon avec des émissions de gaz de combustion.
Patent CA-3013305-A1 (CA)
Title: Entrainement a vitesse variable a haute vitesse a niveaux multiples
Inventor: SANTAMARIA GEORGE THOMAS
IPC: H02P27/06
Filed: 2016-09-26
Abstract: Selon l'invention, un entraînement à vitesse variable à haute vitesse à niveaux multiples comporte une pluralité de ponts onduleurs triphasés modulaires à niveaux multiples, où les ponts onduleurs triphasés à niveaux multiples fonctionnent avec une fréquence fondamentale (f), où les ponts onduleurs triphasés à niveaux multiples comprennent au moins trois niveaux, où les ponts onduleurs triphasés à niveaux multiples fonctionnent en mode à modulation de largeur d'impulsion (MLI) avec un facteur de multiplication de 9 à 21 ou fonctionnent en mode de fréquence fondamentale (FFM), où la fréquence de commutation d'onduleur est égale à la fréquence fondamentale, où les onduleurs triphasés à niveaux multiples fonctionnent avec une phase auxiliaire de sorte qu'un groupe soit déphasé par rapport à l'autre d'un angle ? = 60/q, où le déphasage d'une composante harmonique d'ordre n entre les groupes, ?n, est n?/q ; un moteur polyphasé à haute vitesse avec des phases agencées en q groupes triphasés ; et des moyens électromagnétiques de blocage de groupes sélectionnés d'harmoniques tout en laissant passer des composantes à la fréquence fondamentale (f), où les moyens électromagnétiques comprennent des bobines transportant du courant de moteur reliées par un noyau magnétique, où les moyens électromagnétiques sont interposés entre la pluralité de ponts onduleurs triphasés modulaires à niveaux multiples et le moteur polyphasé à haute vitesse.
Patent CA-3013673-A1 (CA)
Title: Compositions topiques non aqueuses comprenant un salicylanilide halogene
Inventor: SOMMER MORTEN OTTO ALEXANDER
IPC: A61K31/609
Filed: 2017-03-15
Abstract: La présente invention concerne des compositions topiques non aqueuses comprenant un salicylanilide halogéné et l'utilisation de telles compositions dans le traitement topique ou la prévention de maladies et d'infections, en particulier des affections causées par des bactéries Gram-positif, par exemple le traitement ou la prévention topique d'infections cutanées telles que l'acné, la dermatite atopique et l'impétigo. L'invention concerne en outre des procédés pour préparer la composition de gel.