baber/WOPTO huggingface dataset:
Patent BR-112023001296-A2 (BR)
Title: Combinações farmacêuticas em forma de dosagem parenteral e método para preparar uma composição farmacêutica em uma forma de dosagem parenteral
Inventor: IBRAHIM TURAN
IPC: A61K31/573
Filed: 2020-07-25
Abstract: COMBINAÇÕES FARMACÊUTICAS EM FORMA DE DOSAGEM PARENTERAL E MÉTODO PARA PREPARAR UMA COMPOSIÇÃO FARMACÊUTICA EM UMA FORMA DE DOSAGEM PARENTERAL. A presente invenção refere-se a uma nova terapia de combinação para controlar e aliviar a dor. Mais particularmente, a invenção refere-se a uma nova combinação farmacêutica de ação prolongada em forma de dosagem parenteral que pode ser administrada antes ou depois da cirurgia sem causar bloqueio do nervo motor. A combinação farmacêutica de acordo com a presente invenção compreende ropivacaína, clonidina, betametasona, ou os sais e hidratos farmaceuticamente aceitáveis dos mesmos.
Patent BR-112023001926-A2 (BR)
Title: Composição farmacêutica de corticosteroide intra-articular para controle da dor
Inventor: SHEUE-FANG SHIH
IPC: A61K31/573
Filed: 2021-08-05
Abstract: COMPOSIÇÃO FARMACÊUTICA DE CORTICOSTEROIDE INTRA-ARTICULAR PARA CONTROLE DA DOR. A presente invenção refere-se a um método para tratar a dor nas articulações em um indivíduo com artrite. O método compreende administrar ao indivíduo com um determinado grau de osteoartrite uma quantidade eficaz de corticosteroide intra-articular ou sal farmaceuticamente aceitável do mesmo em uma composição farmacêutica. É alcançada robustez da resposta de eficácia a um tratamento com corticosteroide intra-articular em subgrupos predeterminados da população com intenção de tratar.
Patent BR-112023002436-A2 (BR)
Title: Formulações de revestimento marítimo
Inventor: MARK SCEATS
IPC: C09D5/16
Filed: 2021-08-11
Abstract: FORMULAÇÕES DE REVESTIMENTO MARÍTIMO. Uma formulação para um revestimento para aplicações em infraestrutura marítima ou embarcações para inibir incrustações e corrosão que compreende: (a) um material nanoativo; e (b) um aglutinante de polímero; e (c) aditivos que incluem pigmentos, anti-incrustantes de reforço, materiais anticorrosivos de reforço, solventes, ativadores de polimerização, modificadores de viscosidade e enchimentos, onde o material nanoativo, o aglutinante e os aditivos fornecem ao revestimento com as propriedades mais desejáveis de anti-incrustação, anticorrosão, adesão e resistência, necessários para a aplicação do revestimento.
Patent SK-3796-A3 (SK)
Title: Process for the synthesis of azetidinones
Inventor: THIRUVENGADAM TIRUVERTIPURAM K
IPC: C07D205/08
Filed: 1994-07-01
Abstract: PCT No. PCT/US94/07291 Sec. 371 Date Jan. 4, 1996 Sec. 102(e) Date Jan. 4, 1996 PCT Filed Jul. 1, 1994 PCT Pub. No. WO95/01961 PCT Pub. Date Jan. 19, 1995This invention provides a process for preparing azetidinones useful as intermediates in the synthesis of penems and as hypocholesterolemic agents, particularly for azetidinones substituted in the C-3 and C-4 positions and optionally substituted at the ring nitrogen, comprising reacting a  beta -(substituted-amino)amide, a  beta -(substituted-amino)acid ester, or a  beta -(substituted-amino)thiolcarbonic acid ester with a silylating agent and a cyclizing agent.
Patent CZ-11197-A3 (CZ)
Title: Use of phospholipases in feeding stuffs of animals
Inventor: BEUDEKER ROBERT FRANCISCUS
IPC: A23K1/165
Filed: 1996-05-15
Abstract: The present invention discloses a process for improving the efficiency of feed utilization and/or for promoting the growth of animals in which an animal is fed a diet which comprises a composition comprising feed substance and a ready for use phospholipase additive. Preferably said composition also comprises at least one phospholipid. Said compositions are used to improve fat digestibility and to promote growth of the animal. The phospholipid is preferably lecithin and the preferred phospholipase is a mammalian phospholipase A2. In a preferred embodiment the phospholipase is produced using recombinant DNA technology to express the enzyme in a suitable host such as a microorganism or a transgenic plant.
Patent CZ-58399-A3 (CZ)
Title: Agricultural harvesting machine
Inventor: SMIT MAKSIMILIJAN
IPC: A01D78/10
Filed: 1997-08-20
Abstract: The invention refers to the agricultural harvesting device, such as for example the swather (20) and the tedder (21) or in general to devices with at least one vertical axle and feeling-supporting device (1), on which a rotating element is fixed with adequate operating devices in such a way, that it can be vertically adjusted. In this case this is the agricultural harvesting device with the feeling-supporting device (1) which is flexibly connected through the support (16) of the chassis and the supporting axle (25) with the mounting plate (15), on which the oscillating bonds (8, 9) are embedded in adequate hinges (12, 14). The oscillating bonds (8, 9) are connected with each other by means of a connecting pivot pin (11). The mentioned feeling-supporting device (1) consists of at least four wheels (3, 4) which are connected through the oscillating bonds (8, 9) and the connecting pivot pin (11) or the support (11') of the connecting pivot pin (11). The oscillating bonds (8, 9) are embedded in hinges (12, 14), enabling oscillation in the vertical plane, on the mounting plate (15) in such a way, that they can oscillate; the mounting plate (15) is clamped towards the support (16) of the chassis by means of the axle (25) in such a way, that it can oscillate, which enables the oscillation around the vertical axis.
Patent SK-25395-A3 (SK)
Title: Device for foodstuffs mass aseptic dosing
Inventor: BRERETON GEOFFREY R
IPC: A23G9/28
Filed: 1995-02-24
Abstract: Apparatus for aseptically dispensing two or more streams of different foodstuffs is disclosed. The apparatus comprises a dispensing head, coupling means and two or more laterally spaced aseptic fillers, the dispensing head (14) comprising two or more conduit means separate from each other and providing passages for the respective streams. The conduit means have outlets which are arranged such that foodstuffs may be dispensed through all outlets simultaneously into a single container and the dispensing head is sealingly attached directly to one filler head (11) and is connected to the other filler (12) or fillers by the coupling means (33,16,34) to allow the foodstuffs to pass from the fillers to the conduit means. <IMAGE>
Patent SK-87496-A3 (SK)
Title: Process for producing polyester and copolyester by using polycondensation of initial components creating polyester and use of the polycondensing catalysts
Inventor: MARTL MICHAEL
IPC: C08G63/87
Filed: 1994-12-28
Abstract: PCT No. PCT/EP94/04333 Sec. 371 Date Jul. 5, 1996 Sec. 102(e) Date Jul. 5, 1996 PCT Filed Jan. 2, 1995 PCT Pub. No. WO95/18839 PCT Pub. Date Jul. 13, 1995For the preparation of polyesters and copolyesters, titanium dioxide/silicon dioxide coprecipitates having a composition of TiO2:SiO2=90:10 to 20:80 mol/mol and/or titanium dioxide/zirconium dioxide coprecipitates having a composition of TiO2 : ZrO2=95:5 to 70:30 mol/mol are proposed as polycondensation catalysts. They have a higher catalytic activity than Sb2O3, so that the preferred amount used is only 10 to 100 ppm, based on the esters or oligoesters to be subjected to polycondensation.
Patent SK-89096-A3 (SK)
Title: Antiresonant shaft clutch with selfregulation
Inventor: LACKO PAVOL
IPC: F16D3/12
Filed: 1996-07-10
Abstract: The invention relates to an antiresonant shaft clutch with selfregulation of dynamic torsion rigidity containing a driving hob (1) which is attached on a driving shaft (8). The hob (1) is prevented from rotating on the shaft (8) by means of a spring (9). A piston with a sealing ring (10) is axially displaced in the cylinder (2) upon which a freely rotating torsion dynamic pendulum (4) with a liner (11). A two-arm ratchet (5) attached via a screw (7) onto said torsion dynamic pendulum (4) is forced into stroke by a spring via a pin (12). End stops (13 and 14) determine the axial movement of the piston (3) and overpoling thereof. A compression chamber of the clutch is connected with a pressure (6) regulator of gas medium.
Patent CH-630501G-A3 (CH)
IPC: G04G5/02
Filed: 1978-05-11
Abstract: Time adjusting means for electronic timepiece which detects change in the generation condition of pulses generated in response to a manual operation speed and generates a predetermined number of pulses in accordance with the detection output as the time-adjusting pulses. The time adjusting means enables a rapid time adjustment of an electronic timepiece at a high speed. When the manual operation speed exceeds a predetermined speed, the time adjusting means stops the time-adjusting pulse so as to prevent erroneous operation.
Patent CZ-199892-A3 (CZ)
Title: Injection nozzle used in injection moulding process
Inventor: GUZZINI VINICIO
IPC: B29C45/20
Filed: 1992-06-26
Abstract: Injection nozzle for an injection mould with a rectilinear material feedline, having a closure part arranged in a bore which intersects the material feedline in an inclined manner and opens into the injection opening, the head of the closure part completely releasing the material feedline during the injection process and, after execution of the injection operation, blocking the injection opening again. <IMAGE>
Patent CZ-210992-A3 (CZ)
Title: Pyrazolopyrimidine compounds, process of their preparation and use
Inventor: BELL ANDREW SIMON
IPC: A61K31/535
Filed: 1992-07-07
Abstract: Compounds of formula: <CHEM>  and pharmaceutically acceptable salts thereof,  wherein R<1> is H; C1-C3 alkyl optionally substituted with one or more fluoro substituents; or C3-C5 cycloalkyl; R<2> is H, or C1-C6 alkyl optionally susbtituted with one or more fluoro subtituents or with C3-C6 cycloalkyl; R<3> is C1-C6 alkyl optionally substituted with one or more fluoro substituents or with C3-C6 cycloalkyl; C3-C5 cycloalkyl; C3-C6 alkenyl; or C3-C6 alkynyl; R<4> is C1-C4 alkyl optionally substituted with OH, NR<5>R<6>, CN, CONR<5>R<6> or CO2R<7>; C2-C4 alkenyl optionally substituted with CN, CONR<5>R<6> or CO2R<7>; C2-C4 alkanoyl optionally substituted with NR<5>R<6>; hydroxy C2-C4 alkyl optionally susbtituted with NR<5>R<6>; (C2-C3 alkoxy)C1-C2 alkyl optionally substituted with OH or NR<5>R<6>; CONR<5>R<6>; CO2R<7>; halo; NR<5>R<6>; NHSO2NR<5>R<6>; NHSO2R<8>; or phenyl or heterocyclyl either of which is optionally substituted with methyl; R<5> and R<6> are each independently H or C1-C4 alkyl, or together with the nitrogen atom to which they are attached from a pyrrolidinyl, piperidino, morpholino, 4-(NR<9>)-piperazinyl or imidazoyl group wherein said group is optionally substituted with methyl or hydroxy; R<7> is H or C1-C4 alkyl; R<8> is C1-C3 alkyl optionally substituted with NR<5>R<6>; and R<9> is H; C1-C3 alkyl optionally substituted with phenyl; hydroxy C2-C3 alkyl; or C1-C4 alkanoyl; are selective cGMP PDE inhibitors useful in the treatment of cardiovascular disorders such as angina, hypertension, heart failure and atherosclerosis.
Patent CZ-346791-A3 (CZ)
Inventor: ENGST PAVEL ING CSC
IPC: G01K11/02
Filed: 1991-11-15
Abstract: Způsob využívá princip permeace plynu látkou. Rychlost
permeace je časovým integrálem teplot měřených těles. Zařízení
pro toto míření se umísťuje na topné těleso a spotřebované
teplo se určuje z úbytku kapaliny (5) v permeační
tubě (4) např. odečítáním z kalibrační stupnice (12).
Patent CS-408091-A3 (CS)
Title: Isoindoline derivatives, process of their preparation and application
Inventor: GOTO GIICHI
IPC: C07D471/04
Filed: 1991-12-27
Abstract: A compound of the formula  <IMAGE>  wherein X is hydrogen, halogen or nitro; Ar is phenyl or naphthyridinyl which may optionally be substituted; and either one of Z1 and Z2 is hydrogen and the other is lower alkanoyloxy or hydroxy, each of Z1 and Z2 is lower alkoxy, or Z1 and Z2 combinedly represent hydroxyimino, oxo or a group of the formula:  <IMAGE>  in which Y is oxygen or sulfur and A is a branched or unbranched lower alkylene chain; and a salt thereof, act on the central nervous system but are weak in adverse effects such as hypnotic and muscle relaxant effects.
Patent CZ-767587-A3 (CZ)
Inventor: WALLNER FELIX DR DIPL ING
IPC: H01M6/52
Filed: 1987-10-26
Abstract: Způsob se týká zvláště přístrojových baterií (1), jako uhlíko-zinkových
a alkalicko-burelových baterií (1), které se
předběžné třídí za účelem oddělení od akumulátorů a knoflíkových
článků, načež se mechanicky otvírají v nárazových
mlýnech (2, 7,14,19, 21) a rozdrcené části se prosévají. Po
prvním prosetí se z nadsítné frakce odlučuje magneticky
magnetická frakce (12) a nadsítná frakce se vede podruhé
do nárazového mlýna (7) a rozdrcené částice se znovu
magneticky prosěvají, přičemž se získaná magnetická frakce
(17) odlučuje a podsítná nemagnetická frakce (28) se
zbavuje filtrací alkalických a amonných solí, propírá se a
tepelně zpracovává. Nemagnetické nárazovým mlýnem nerozdrccné
části nadsítných frakcí je tepelně zpracovávají.
Magnetická frakce (17), získaná při druhém prosévání se
zpracovává odděleně od první magnetické frakce (12).
Magnetické odlučování se provádí pásovými a bubnovými
magnetickými odlučovači (5, 6, 10, 11, 15, 22). Uvádějí se
jednotlivé fáze zpracování drcením ve mlýnech (2, 7, 14,
19, 21) a proséváním získaných materiálových složek použitých
primárních článků.
Patent CZ-106497-A3 (CZ)
Inventor: SKRKON JOSEF
IPC: H01B3/48
Filed: 1997-04-08
Abstract: Kompozitní izolátor s nosnou tyčí /1 / s
integrovanými upevňovacími koncovkami /2/
a s kompaktním pláštěm /3/ s povětrnostními
stříškami /4/ pro venkovní elektrické
linky, má nosnou tyč /1/ s upevňovacími
koncovkami /2/ tvořenou celoplastovým monolitem,
například z termopalstu nebo termosetu
s případně ve hmotě obsaženými zpevňujícími
vlákny. Monolit nosné tyče /1 / s
koncovkami /2/, obklopuje od konce ke konci
přes oka /5/ koncovek /2/ do nekonečné
smyčky uspořádanou vlákennou výztuž /11/,
která obepíná v koncovkách /2/ případná
pouzdra /13/ s oky /5/ a s obvodovými vybráními
/14/ pro vlákennou výztuž /11/,
opatřených eventuálně čelními otvory /15/ k
upevnění konců této vlákenné výztuže /11/.
Nosná tyč /1/ je mezi koncovkami /2/
opatřena z vnějšku elastickým pláštěm /3/ s
intergrálními povětrnostními stříškami /4/ s
obvodovými odkapávacími hranami /8/ a je
dále mezi koncovkami /2/ opatřena z vnějšku
sostavou radiálních aretačních výstupků /7/
pro řečený elastický plášť /3/. Na horním rozhraní
mezi nosnou tyčí /1/ a pláštěm /3/ je
uspořádán krycí nákružek /10/.
Patent CZ-115696-A3 (CZ)
Title: Stone heating panel, particularly of natural stone
Inventor: SEVERA KAREL
IPC: F24D19/06
Filed: 1996-04-22
Abstract: A heating plate (1) made of stone, preferably natural stone, heated by means of a heat transfer liquid, has a heating body (2) anchored in its rear side (11) and joined with its front surface (21) to the rear wall (11) of the stone plate (1) in a flexible and heat-conductive manner. The heating plate and the heating body are supported together by means of supporting holders (3) secured to the wall (7) of the heated room.
Patent CZ-169498-A3 (CZ)
Inventor: REMMEL ROGER
IPC: B60P7/00
Filed: 1998-06-01
Abstract: Shrnovací střecha pro karosérie vozidla a
kontejnery je provedena s nosnou konstrukcí
střechy sestávající zejména z horních
podélných pásů /4/, uspořádaných po celé
délce ložného prostoru a podepřených vzpřímenými
sloupky /1/ a klanlcemi /2/ vůči
podvozku /3/ vozidla. Plachta /5/, zakrývající
alespoň oblast střechy, je nesena příčnými
vzpěrami /8/, uspořádanými po celé šířce
ložné plochy a prostřednictvím vozíků /6/ s
kladkami posuvně v podélném směru vozidla
uloženými na podélných pásech /4/ nosné
konstrukce střechy. Navzájem sousední příčné
vzpěry /8/ jsou v oblasti obou podélných
stran střechy navzájem spojeny
prostřednictvím dosedacího elementu /11/
pro plachtu /5/ sklopltelného kolem alespoň
dvou předem vyznačených ohybových linií /9,
10/ tak, že zmenšení odstupu mezi dvěma
sousedními příčnými vzpěrami /8/ v této
oblasti vede ke složení plachty /5/ směřujícímu
nahoru. Dosedací elementy /11/ dosedají
svými konci na příčné vzpěry /8/ a jsou průchozími
upevňovacími prostředky upevněnyna příčných vzpěrách /8/, jakož i v
oblasti mezi příčnými vzpěrami /8/
jsou opatřeny podpěrami, dosedajícími
při uzavřené střeše na přiřazený
podélný pás /4/. Ohybové linie /9, 10/
dosedacích elementů /11/, sousedící s
dosedacími místy na příčných vzpěrách
/8/, jsou uspořádány pod úhlem vůči
podélné ose příčných vzpěr /8/.
Patent CZ-198095-A3 (CZ)
Title: Electromagnetically controllable valve
Inventor: REITER FERDINAND
IPC: B23K9/04
Filed: 1994-11-24
Abstract: In already known fuel injection valves, wearing parts such as the armature and the core are provided with wear-resistant layers made for example of chromium, molybdenum or nickel. If the parts of the injection valve are galvanically coated, a desired wedge-shaped distribution of the layer thicknesses is achieved that creates only a small bearing area but which is physically predetermined and practically impossible to influence. The new valve has at least one part, for example the armature (27) that has a stepped surface before the wear-resistant layer is applied. The stepped surface may be produced in a variable manner depending on the desired optimum magnetic and hydraulic properties. The ring-shaped bearing section (69) formed by the step has a defined bearing surface or contact width (b) that remains constant during the whole service life of the part, as wearing of the bearing surface in continuous duty does not cause the contact width to increase. This valve is particularly suitable for use in fuel injection systems of mixture compressing, spark-ignited internal combustion engines.
Patent CZ-200776-A3 (CZ)
Inventor: MERTA PETR
IPC: E21B17/02
Filed: 2007-01-30
Abstract: Protikorozní úprava závitového spoje, snižující jeho trení a zvyšující jeho protikorozní ochranu, zejména u potrubí používaného u vrtných souprav, spocívá v opatrení závitu tepelne vytvrzenou vrstvouhmoty o tlouštce minimálne 5 .mi.m na bázi fluoropolymeru, napríklad PTFE. Zpusob protikorozní úpravy závitu spocívá v odmaštení, opláchnutí a morenízávitu, dalším opláchnutí a fosfátování. Po jeho osušení je provedení nástriku fluoropolymerovým lubrikantem a usušení pri teplote 25 až 100 .degree.C. Poté je realizováno vytvrzení povlaku závitu jeho vložením na dobu minimálne 5 minut do prostoru o teplote 200 až 275 .degree.C.
Patent CZ-242193-A3 (CZ)
Title: Tantalum or niobium alloy containing silicon and combined additives for forming
Inventor: KUMAR PRABHAT
IPC: H01G9/012
Filed: 1992-05-15
Abstract: A wrought metal alloy product having a tantalum or niobium base metal, 10 to 1000 ppm silicon, and 10 to 10000 ppm yttrium nitride. Fine uniform grain size contributes to improved ductility.
Patent CZ-265199-A3 (CZ)
Title: Use of gastrointestinal lipase inhibitors
Inventor: HAUPTMAN JONATHAN BRIAN
IPC: A61P3/10
Filed: 1998-01-29
Abstract: A method for treating or preventing type II diabetes mellitus comprising administering an effective amount of a gastrointestinal lipase inhibitor, such as, tetrahydrolipstatin.
Patent CZ-283299-A3 (CZ)
Title: Decomposition process of hydrogen peroxide
Inventor: DRULINER JOE DOUGLAS
IPC: B01J21/08
Filed: 1998-02-10
Abstract: An improved process for decomposing alkyl or aromatic hydroperoxides to form a decomposition reaction mixture containing the corresponding alcohol and ketone. The improvement relates to decomposing the hydroperoxide by contacting the hydroperoxide with a catalytic amount of a heterogenous catalyst of Au, Ag, Cu or a sol-gel compound containing particular combinations of Cr, Co, Zr, Ta, Si, Mg, Nb, Al and Ti wherein certain of those metals have been combined with an oxide, such as an inorganic matrix of hydroxides or oxides, or combinations thereof. The catalysts may also optionally be supported on a suitable support member.
Patent CZ-289999-A3 (CZ)
Inventor: HELM PETER DIPL ING
IPC: B01D53/38
Filed: 1999-08-13
Abstract: Způsob spočívá v tom, že se odváděný odpadní vzduch stlačí
na vyšší tlak a potomse zavede do kapaliny. Zařízení (1) pro
čištění odpadního vzduchu z kuchyňských přístrojů obsahuje
odváděči potrubí (3) pro odvádění odpadního vzduchu z
kuchyňských přístrojů, ústrojí (7) pro zvětšování tlaku
odpadního vzduchu z kuchyňských přístrojů, kapalinovou
lázeň (13) a přívodní potrubí (9) pro přivádění odpadního
vzduchu do kapalinové lázně (13).
Patent CZ-326899-A3 (CZ)
Inventor: BUESCHKEN WILFRIED DR
IPC: C07C5/03
Filed: 1999-09-15
Abstract: Popisuje se způsob hydrogenace reakčních směsí
z hydroformylaceC^-olefinů pomocí vodíku na pevných
katalyzátorech při zvýšené teplotě, při kterémse z reakční
směsi odpaří aldehydy, alkoholy, mravenčany a nízkovroucí
látky a v parách se vedou přes Cu/Cr-katalyzátorbez nosiče.
Patent CZ-338798-A3 (CZ)
Title: Digital information system
Inventor: HYLIN MATS
IPC: G09F13/04
Filed: 1997-04-23
Abstract: The display system has projectors (22) at a number of public places, e.g. railway stations. The projectors are connected and controlled by local computers (34,38) that are linked through a communication system, e.g. radio (14), to a central computer system (10). Projectors are many places of different types can be linked to this system. Also connected to the central system are information mediators (24). These may be advertisers or any other source requiring to present public displays. The information suppliers can be allowed to directly book dispaly time slots through the central computer which then organised the distribution of the display material.
Patent CZ-9903552-A3 (CZ)
Inventor: BALES KELLY RENEE
IPC: A61K31/55
Filed: 1998-04-07
Abstract: Tento vynález poskytuje způsob léčení depresí, náhlých změn
nálad nebo Alzheimerovy choroby u pacienta, který potřebuje
toto léčení, při kterém se podává sloučenina obecného vzorce
a modulující receptory estrogenů, ve které R1 a R2 jsou
navzájem nezávisle hydroxylová skupina nebo alkoxyskupina
o jednom až čtyřech atomech uhlíku a R3 a R4 jsou nezávisle
na sobě methylová nebo ethylová skupina nebo R3 a R4 spolu
s atomem dusíku, ke kterému se připojují, vytvářejí
pyrrolidinový, methylpyrrolidinový, dimethylpyrrolidinový,
piperidinový, morfolinový nebo hexamethyleniminový kruh.
Patent CZ-379099-A3 (CZ)
Title: Stereoselective microbial reduction of racemic tetralone
Inventor: MORSE BROOK KNIGHT
IPC: C12P7/22
Filed: 1999-10-25
Abstract: The present invention relates to processes for carrying out the following stereoselective microbial reduction of a racemic tetralone:   <CHEM> which comprises: contacting a compound of formula (I) with a microorganism, or an enzyme reduction system capable of accomplishing the subject reduction comprising an enzyme derived from said microorganism and a co-factor for said enzyme, and incubating the resulting mixture under conditions sufficient to yield the (4R) tetralol of formula (II) and to leave substantially unreacted the (4S) tetralone of formula (V) or "chiral tetralone." The chiral tetralone can be used in the synthesis of sertraline. The subject process further optionally comprises the separation of the (4S) tetralone of formula (V) from the (4R) tetralol of formula (II). The (4R) tetralol can be recycled to produce the compound of formula (I) and the subject process repeated to result in even more of the desired (4S) tetralone of formula (V).
Patent CZ-407097-A3 (CZ)
Title: Anti-obesity proteins, process of their preparation and pharmaceutical composition containing thereof
Inventor: BEALS JOHN MICHAEL
IPC: C07K14/47
Filed: 1997-12-17
Abstract: The present invention provides anti-obesity proteins wherein at least one of the Trp 100 or Trp 138 is replaced by Glu, Asp, His, Lys or Arg, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type 2 diabetes, cardiovascular disease, and cancer.