baber/WOPTO huggingface dataset:
Patent WO-2019178613-A1 (WO)
Title: B cells genetically engineered to secrete follistatin and methods of using the same to treat follistatin-related diseases, conditions, disorders and to enhance muscle growth and strength
Inventor: SCHOLZ MATTHEW REIN
IPC: C12N5/0781
Filed: 2019-03-18
Abstract: The present invention relates to methods for administering autologous and/or allogeneic B cells genetically modified to produce a therapeutic agent, such as follistatin. Specifically disclosed are methods for administering a single, maximally effective dose of genetically modified B cells and for administering multiple doses of genetically modified B cells that express follistatin. The compositions and methods disclosed herein are useful for the long-term,  in vivo  delivery of follistatin.
Patent WO-2019195202-A1 (WO)
Title: A fuel injector for on-demand multi-fuel injection
Inventor: HOU DEYANG
IPC: F02M61/10
Filed: 2019-04-02
Abstract: A fuel injector has means to directly inject one type of fuel or two types of fuels collectively with fuel ratios on demand. Once being used as a single fuel injector, the injector can enable injection rate shaping. Once being used as a dual fuel injector, the injector can tailor fuel properties on demand. The fuel injector has the capability to enable tailored chemical and thermal-physical fuel properties to enable high efficiency clean combustion for different engine loads and speeds.
Patent WO-2019195232-A1 (WO)
Title: Integrated separator and distributor
Inventor: MOORE BRYCE KIRK
IPC: F25B43/00
Filed: 2019-04-02
Abstract: A separator and distributor assembly for a falling film evaporator housed within the evaporator shell includes a housing defining a separation volume, a refrigerant inlet configured to admit a liquid and vapor refrigerant flow into the separation volume and one or more refrigerant gutters extending along a lengthwise axis of the housing. The refrigerant gutter has a gutter inlet at a bottom of the separation volume, and the one or more refrigerant gutters are configured to receive separated liquid refrigerant from the separation volume. One or more sparge channels are in fluid communication with the refrigerant gutters. The sparge channel includes one or more sparge openings at a top of the sparge channel vertically below the gutter inlet. The one or more sparge openings are configured to flow liquid refrigerant therefrom.
Patent WO-2019200300-A1 (WO)
Title: Large-scale mapping of protein-protein interactions from crosslinking mass spectrometry
Inventor: YU HAIYUAN
IPC: G01N33/48
Filed: 2019-04-12
Abstract: A processing platform in one embodiment comprises one or more processing devices each including at least one processor coupled to a memory. The processing platform is configured to implement a crosslink identification and validation algorithm for processing multiple levels of mass spectrometry data in order to identify and validate protein-protein interactions within the mass spectrometry data. In conjunction with execution of the crosslink identification and validation algorithm, the processing platform is further configured to obtain mass spectrometry spectra for each of the multiple levels, to apply a header matching filter to identify at least one potential crosslink relating one or more first level spectra and one or more second level spectra utilizing a plurality of third level spectra, and to apply one or more mass validation filters to identify whether or not the potential crosslink is a valid crosslink.
Patent WO-2019213444-A1 (WO)
Title: Antibodies, activatable antibodies, bispecific antibodies, and bispecific activatable antibodies and methods of use thereof
Inventor: PAIDHUNGAT MADAN M
IPC: A61P35/00
Filed: 2019-05-02
Abstract: Provided herein antibodies, activatable antibodies (AAs), bispecific antibodies, and bispecific activatable antibodies (BAAs). Also provided herein are methods of making and methods of use of these antibodies, AAs, bispecific antibodies, and BAAs.
Patent WO-2019217450-A1 (WO)
Title: Anti-chi3l1 antibodies for the detection and/or treatment of nonalcoholic fattly liver disease/nonalcoholic steatohepatitis and subsequent complications
Inventor: WANDS JACK
IPC: A61P19/02
Filed: 2019-05-07
Abstract: The present disclosure relates to antibodies that bind human chitinase-3-like protein 1 (CHI3L1) and uses thereof. In aspects, the antibodies are useful in compositions and methods for detecting and/or treating nonalcoholic steatohepatitis (NAFLD) or nonalcoholic fatty liver disease (NASH) in a subject, as well as subsequent complications of untreated progression in the liver of a subject, such as liver cirrhosis and/or a hepatocellular carcinoma.
Patent WO-2019217535-A1 (WO)
Title: Exhaust gas filter for reflow oven
Inventor: WANG YUWEI
IPC: B23K3/08
Filed: 2019-05-08
Abstract: An exhaust gas filter for a reflow oven is disclosed, which comprises a filter chamber, a filtering piece and a vapor chamber. An upper transverse passage is formed between the vapor chamber top plate and the filter element, a gap is formed between one side of the top plate and the sidewall of a filter chamber, and the upper transverse passage is in fluid communication with the gap; one filter chamber sidewall forming a gap with the top plate is disposed with a filter chamber air inlet for introducing air, and one of the other three sidewalls of the filter chamber is disposed with an exhaust gas inlet for introducing exhaust gas from the exhaust gas filter chamber, so that the air and the exhaust gas can enter the upper transverse passage through the gap. A vapor chamber is disposed to sufficiently mix the exhaust gas and the air, thus lowering the exhaust gas temperature below the freezing point of the rosin, and better removing the flux contaminant in the exhaust gas. Meanwhile, a slide-fitted outer casing and a filter chamber are provided, which makes it easier to disassemble and clean the filter chamber.
Patent WO-2019236852-A1 (WO)
Inventor: POLYMEROPOULOS MIHAEL
IPC: A61P25/36
Filed: 2019-06-06
Abstract: L'invention concerne des méthodes de traitement d'un individu souffrant, ou risquant de souffrir, d'une conséquence indésirable de la consommation d'opioïdes, et de traitement d'un individu qui souffre, ou qui risque de souffrir, d'un manque d'opioïdes, ainsi que l'utilisation de l'antagoniste des récepteurs de la NK-1, le tradipitant, dans le traitement d'un tel individu.
Patent WO-2019245798-A1 (WO)
Title: Couches d'extraction de lumière interne durcies par rayonnement infrarouge proche
Inventor: LIN JEN-CHIEH
IPC: B05D3/06
Filed: 2019-06-11
Abstract: L'invention concerne un procédé de formation d'un article pour une extraction de lumière améliorée comprenant : la fourniture d'un substrat de base ; la disposition d'un précurseur sur le substrat de base, le précurseur présentant : des particules présentant un diamètre moyen dans une plage de 10 nm à 1 µm et comprenant un oxyde inorganique et un liant organique ; l'exposition du précurseur à un premier rayonnement présentant une longueur d'onde d'émission de pic dans une plage de 500 nm à 2000 nm pendant un temps dans une plage de 1 seconde à 300 secondes pour former une couche d'extraction de lumière poreuse présentant un diamètre de pore moyen dans une plage de 10 nm à 1000 nm, de sorte que la couche d'extraction de lumière poreuse améliore la sortie de lumière de l'article d'un facteur de 1,7 x ou plus.
Patent WO-2019246111-A1 (WO)
Title: Virus oncolytique ou antigène présentant une thérapie anticancéreuse à médiation par des cellules utilisant un interféron de type i et un ligand cd40
Inventor: BEG AMER
IPC: C07K14/705
Filed: 2019-06-18
Abstract: L'invention concerne des cellules présentatrices d'antigène (CPA), telles que des cellules dendritiques (CD), comprenant une combinaison d'un interféron de type I exogène et d'un CD40-L exogène ou d'une ou de plusieurs séquences d'acides nucléiques hétérologues codant pour une combinaison d'un IFN de type I exogène et d'un CD40-L exogène, tels qu'une combinaison d'ΙFΝβ et de CD40-L ; ainsi que des méthodes de traitement d'une tumeur maligne par administration de telles cellules présentatrices d'antigène (CPA) à un sujet qui en a besoin. Selon certains modes de réalisation de la présente invention, un sujet est traité par radiothérapie avant l'administration des CPA, telles que des CD, selon l'invention. L'invention concerne également un virus oncolytique comprenant une combinaison d'un IFN de type I et d'un CD40-L ou d'une ou de plusieurs séquences d'acides nucléiques codant pour une combinaison d'un IFN de type I et d'un CD40-L, tels qu'une combinaison d'IFNβ et de CD40-L ; ainsi que des méthodes de traitement d'une tumeur maligne par administration d'un tel virus oncolytique à un sujet qui en a besoin.
Patent WO-2020009962-A1 (WO)
Title: Dry slide assay using reduced reading window
Inventor: DING ZHONG
IPC: G01N35/10
Filed: 2019-07-01
Abstract: The present disclosure is directed to a method and apparatus for performing an assay on a dry slide or other solid media using a reduced reading window. In an embodiment, method of performing at least one assay comprises obtaining an image of a fluid sample located on a dry slide, positioning a reading window to correspond to an area of the fluid sample in the image, determining an interference area within the reading window based on light intensity, reducing the reading window to eliminate the interference area from the reading window, and performing at least one assay using the reduced reading window.
Patent WO-2020014174-A1 (WO)
Title: Methods and devices that change color to indicate the presence of opioids and other narcotics
Inventor: JOY ABRAHAM
IPC: G01N21/77
Filed: 2019-07-09
Abstract: A safe and reliable drug detection device is provided that detects the presence of opioids and other amine-containing drugs, and enables first responders, law enforcement personnel, and others to avoid inadvertent exposure to these potentially lethal drugs. The detector device includes a substrate and a dye that produces a visible color change rapidly when the device is brought into contact with an opioid or other amine-containing drug. A method for preparing the detector device and a method for detecting opioids and other amine-containing drugs on a surface are also provided.
Patent WO-2020018537-A1 (WO)
Title: Cable to reduce optical fiber movement and methods to fabricate
Inventor: DOWD EDWARD
IPC: G02B6/44
Filed: 2019-07-16
Abstract: Certain aspects of the present disclosure provide techniques for making armored cables. An example method for making an armored cable includes forming a strip stock into an armor tubing; welding a seam of the armor tubing in a welding zone; inserting at least one of a first optical fiber or a first wire into a first end of a first guide tube, wherein: the first guide tube extends through the welding zone; the first guide tube protects the at least one of the first optical fiber or the first wire during the welding of the seam; and the first guide tube is not part of the armored cable after the making of the armored cable; and supporting the first guide tube within the armor tubing by a plurality of support legs such that the first guide tube does not contact the armor tubing.
Patent WO-2020018833-A1 (WO)
Inventor: SHERMAN DAVID
IPC: C12N9/10
Filed: 2019-07-18
Abstract: L'invention concerne des biocatalyseurs qui halogènent des composés chimiques complexes de manières spécifiques et prévisibles. L'invention concerne également des composés organiques complexes halogénés. L'invention concerne en outre des procédés d'halogénation de composés chimiques complexes et des procédés d'inhibition de la contraction du muscle lisse chez les mammifères.
Patent WO-2021021117-A1 (WO)
Inventor: TSAI CHENG-HAN
IPC: H05K5/03
Filed: 2019-07-30
Abstract: An example apparatus includes a first flexible portion connected to a second flexible portion. The first flexible portion includes a keyboard having a set of input keys disposed thereon and circuitry coupled to the set of input keys, the first flexible portion is to couple to a portable computing device proximal to a display side of the portable computing device. The second flexible portion has a plurality of fasteners to couple to a kickstand of the portable computing device, the first and second flexible portion to provide an opposing force there between while the kickstand is disposed at one of a plurality of variable support angles.
Patent WO-2021021179-A1 (WO)
Inventor: ZAWADZKI PAWEL PIOTR
IPC: G06N20/00
Filed: 2019-07-31
Abstract: A method and system trains, with a machine learning process, an analysis model to detect anomalous behavior of tax professionals affiliated with a tax return preparation system. The analysis model is trained with a training set that includes contextual and behavioral data for a plurality of historical tax professionals. The trained analysis model then analyzes and generates risk scores for current tax professionals based on current behavioral and contextual data associated with the current tax professionals.
Patent WO-2020037067-A1 (WO)
Title: Applying a positive feedback voltage to an electromechanical sensor utilizing a voltage-to-voltage converter to facilitate a reduction of charge flow in such sensor representing spring softening
Inventor: SEEGER JOSEPH
IPC: G01D5/00
Filed: 2019-08-14
Abstract: Reducing, at a common sense electrode of a group of sensors of a system, a common charge flow due to a common motion of the group of sensors is presented herein. The group of electromechanical sensors generates a common charge flow as a result of a common motion of the group of electromechanical sensors and a differential charge flow as a result of a differential motion of the group of electromechanical sensors - respective sense elements of the group of electromechanical sensors being electrically connected at the common sense electrode. The system further comprises a voltage-to-voltage converter component that generates, via an output of the voltage-to-voltage converter component, a positive feedback voltage, and minimizes the common charge flow by coupling, via a defined feedback capacitance, the positive feedback voltage to the common sense electrode - the common sense electrode being electrically coupled to an input of the voltage-to-voltage converter component.
Patent WO-2020046758-A1 (WO)
Inventor: JANOT VINCENT
IPC: A41D13/08
Filed: 2019-08-23
Abstract: A brace for treating/preventing carpal tunnel injury including a body having a proximal end and a distal end defining s longitudinal direction, the body including a forearm support at the body proximal end, a wrist support coupled to the forearm support by a neck portion, the wrist support comprising a first palmar strap support, a first member and a second member extending from the wrist support in the longitudinal direction towards the distal end, a distal palmar support, a proximal palmar aperture, a palm band having a second palmar strap support, and a palmar strap, extending between a proximal end attached to the first palmar strap support to a distal end, the palmer strap configured to extend across a portion of the back of the hand and over a purlicue of the hand, the distal end of the palmar strap configured to removably attach to the distal palmar support.
Patent WO-2020061173-A1 (WO)
Title: Machine synchrone linéaire homopolaire
Inventor: JEDINGER ALEXANDER
IPC: H02K3/52
Filed: 2019-09-18
Abstract: L'invention concerne des machines synchrones linéaires homopolaires (200) qui comprennent un dispositif de déplacement (111). Le dispositif de déplacement (111) comprend une plaque froide avec des noyaux ferromagnétiques s'étendant à travers des fentes dans la plaque froide. Des couches de bobines d'armature sont situées autour des noyaux ferromagnétiques sur les côtés opposés de la plaque froide. Le dispositif de déplacement (111) comprend en outre au moins une bobine de champ.
Patent WO-2020091929-A1 (WO)
Title: Color accommodation for on-demand accessibility
Inventor: SINGH ASHISH
IPC: A63F13/53
Filed: 2019-09-30
Abstract: Accommodation for color or visual impairments may be implemented by selective color substitution. A color accommodation module receives an image frame from a host system and generates a color-adapted version of the image frame. The color accommodation module may include a rule based filter that substitutes one or more colors within the image frame with one or more corresponding alternative colors.
Patent WO-2020076536-A1 (WO)
Inventor: DYER JOHN
IPC: G09F19/22
Filed: 2019-09-30
Abstract: The disclosure relates to smart signs or physical markers for facilitating passenger trips for autonomous vehicles. For instance, a physical marker 100, 100 A, 100B remote from the autonomous vehicles 370, 372 may receive a first notification indicating a request for a trip has been made via a client computing device 320, 330. The physical marker may determine when the client computing device has reached a physical marker, and in response to the determination, the physical marker may send a second notification to a dispatching server computing device 310 indicating that the client computing device has reached a physical marker. Other aspects of the disclosure relate to various features and uses for the physical marker.
Patent WO-2021076104-A1 (WO)
Inventor: WANG GANG
IPC: H04W12/00
Filed: 2019-10-15
Abstract: Systems and methods are disclosed for protecting data. A device requesting access to the data is required to correctly respond to a challenge embedded in the data provided responsive to a request for the data. If the device that receives the data is able to generate the correct response to the challenge, the device can be validated as the device that was intended to receive the data. When the device is able to generate the correct response to the challenge, the correct response can indicate that the requested data is being used as intended. That is, the challenge can ensure that the context specified in the request, which was deemed an appropriate environment for use of the data by the server that triggered distribution of the data responsive to the request, is, in fact, the context in which the data is actually going to be used.
Patent WO-2020081738-A1 (WO)
Title: System and method for multi-tiered distributed network transactional database
Inventor: KIKINIS DAN
IPC: G06Q20/08
Filed: 2019-10-16
Abstract: A multi-tiered blockchain database system which retains the desirable features of blockchain technology but reduces or eliminates its limitations. The system allows for a primary tier blockchain database that acts as a common linkage to a plurality of lower tier, regional databases with their own separate blockchains. Blockchains at the lower tiers may have a variety of improvements over existing blockchain technology for handling certain applications.
Patent WO-2020086424-A1 (WO)
Inventor: KIM YOUNG DO
IPC: C23C14/24
Filed: 2019-10-21
Abstract: Disclosed herein is an evaporation deposition system for replacing a crucible including:a vacuum chamber configured to accommodate a substrate; an evaporation source configured to supply a vapor deposition material to the substrate; a plurality of moving chambers, each configured to move along a rail and to accomodate the evaporation source; and a connection chamber configured to connect the moving chambers and the vacuum chamber, wherein a front surface of each of the moving chambers is provided with a a first opening, through which the vapor deposition material moves into the connection chamber, and a first on-off valve that opens and closes the first opening.
Patent WO-2020092050-A1 (WO)
Title: Network function (nf) repository function (nrf) having an interface with a segment routing path computation entity (sr-pce) for improved discovery and selection of nf instances
Inventor: STAMMERS TIMOTHY
IPC: H04W48/16
Filed: 2019-10-22
Abstract: A network function (NF) repository function (NRF) suitable for use in a 5G mobile network utilizing segment routing (SR) is described. The first interface of the NRF may be an Nmf interface with a service discovery function. The second interface of the NRF may be for use with a SR path information obtaining function for interfacing with a SR path computation entity (SR-PCE). The service discovery function may be further configured to discover NF instances based on identifying an NF instance being associated with SR path information that accords to least one service, application, or subscription requirement obtained according to the discovery request.
Patent WO-2020092452-A1 (WO)
Title: A robotic system with automated object detection mechanism and methods of operating the same
Inventor: DIANKOV ROSEN
IPC: B25J11/00
Filed: 2019-10-29
Abstract: A system and method for operating a robotic system to register unrecognized objects is disclosed. The robotic system may use first image data representative of an unrecognized object located at a start location to derive an initial minimum viable region (MVR) and to implement operations for initially displacing the unrecognized object. The robotic system may analyze second image data representative of the unrecognized object after the initial displacement operations to detect a condition representative of an accuracy of the initial MVR. The robotic system may register the initial MVR or an adjustment thereof based on the detected condition.
Patent WO-2020092784-A1 (WO)
Inventor: EISELE VAL D
IPC: H04B13/00
Filed: 2019-10-31
Abstract: Techniques for facilitating communication between an implantable medical device and an external device are provided. In one example, a method comprises broadcasting, via communication circuitry of an implantable device, a first set of advertisements at a first advertising rate according to a communication protocol. The method further comprises determining that detection circuitry of the implantable device detected voltage induced by an electromagnetic field at an interface between tissue of a patient and electrodes of the implantable device and in response to the detection of voltage induced by the electromagnetic field, broadcasting, via the communication circuitry, a second set of advertisements at a second advertising rate according to the communication protocol. The second advertising rate is greater than the first advertising rate.
Patent WO-2020097220-A1 (WO)
Title: Systems and methods for compressing audio data for storage and streaming from an aircraft
Inventor: CARRO EDUARDO M
IPC: G10L19/012
Filed: 2019-11-06
Abstract: A system and method of streaming silence-edited audio data from an aircraft is provided. The European Union Aviation Safety Agency (EASA) has dictated that there needs to be a reliable way to recover data from channels recorded onboard an aircraft. The system and method include a silence editing unit which removes periods of silence from an audio signal and maintains a tracking of the time period during which the silence persists. Information of the time period during which the silence persists is transmitted, along with the silence-edited audio signal, via a streaming satellite signal, to be re-constructed at a reception end.
Patent WO-2020102039-A1 (WO)
Title: An optical stimulation system with on-demand monitoring and methods of making
Inventor: LEVEN JACOB
IPC: A61N1/36
Filed: 2019-11-08
Abstract: An adapter to add optical stimulation to a stimulation system includes an adapter body and a connector disposed on the distal end of the adapter body. The connector includes a connector body defining a port and a connector lumen; connector contacts disposed in the connector body and arranged along the connector lumen; and a light source disposed in the connector body. The adapter also includes terminals disposed along the proximal end of the adapter body and conductors extending along the adapter body and electrically coupling the connector contacts and the light source to the terminals. The adapter may be used with an optical stylet that fits into a stimulation lead which is, in turn, coupled to the connector of the adapter. Alternatively, the adapter can include a fiber optic coupled to the light source and configured to extend into the stimulation lead.