Patent SG-11201906763R-A (SG)
Title: Pyrrolo [1,2-b] pyridazine derivatives
Inventor: BACON ELIZABETH
IPC: C07D487/04
Filed: 2018-02-15
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 23 August 2018 (23.08.2018) WIP0 I PCT omit VIII °nolo HE Imo oimIE (10) International Publication Number WO 2018/152368 Al (51) International Patent Classification: CO7D 487/04 (2006.01) A61K 31/5377 (2006.01) CO7D 519/00 (2006.01) A61K 31/5383 (2006.01) A61K 31/5025 (2006.01) A61K 31/541 (2006.01) A61P 29/00 (2006.01) CO7D 453/00 (2006.01) A61K 31/506 (2006.01) (21) International Application Number: PCT/US2018/018431 (22) International Filing Date: 15 February 2018 (15.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/460,013 16 February 2017 (16.02.2017) US (71) Applicant: GILEAD SCIENCES, INC. [US/US]; 333 Lakeside Drive, Foster City, CA 94404 (US). (72) Inventors: BACON, Elizabeth, M.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). BRIZGYS, Gediminas; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). CHIN, El- bert; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Fos- ter City, CA 94404 (US). CHOU, Chienhung; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). COTTELL, Jeromy, J.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). LINK, John, O.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). TAYLOR, James, G.; c/ o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). TSE, Winston, C.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). WRIGHT, Nathan, E.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). YANG, Zheng-Yu; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). ZHANG, Jennifer, R.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). ZIPFEL, Sheila, M.; c/o Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). (74) Agent: POLSTER, Philip, B. et al.; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) 1-1 (54) Title: PYRROLO [1,2-B] PYRIDAZINE DERIVATIVES (57) : Provided is a compound of Formula (I), wherein the variable groups are defined HN ,Ri herein. R3 141\") H • I 1\r N - R4 N 1-1 0 .- 13 R7 R5 R6 (I)