Patent SG-11201807972Y-A (SG)
Title: Combinations of lsd1 inhibitors for the treatment of hematological malignancies
Inventor: CICERI FILIPPO
IPC: A61K31/19
Filed: 2017-03-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization M1111101110101H HO 11111 01E3 100 HE H0111 00 111110111 III 11 International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ...... ... WO 2017/157813 Al 21 September 2017 (21.09.2017) WIP0 I PCT (51) International Patent Classification: AT, Cristina; c/o Oryzon Genomics S.A., C. Sant Ferran A61K 31/12 (2006.01) A61K 31/475 (2006.01) 74, 08940 Cornelia de Liobregat (ES). TIRAPU A61K 31/135 (2006.01) A61K 31/495 (2006.01) FERNANDEZ DE LA CUESTA, Inigo; c/o Oryzon Gen- A61K 31/19 (2006.01) A61K 31/519 (2006.01) omics S.A., C. Sant Ferran 74, 08940 Cornelia de A61K 31/282 (2006.01) A61K 31/555 (2006.01) Liobregat (ES). A61K 31/337 (2006.01) A61K 31/704 (2006.01) A61K 31/4045 (2006.01) A61K 31/7068 (2006.01) (74) Agent: MUELLER-AFRAZ, Simona; Grenzacherstrasse A61K 31/4745 (2006.01) A61P 35/00 (2006.01) 124, 4070 Basel (CH). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/EP2017/055763 kind AO, of national protection available): AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (22) International Filing Date: BZ, 13 March 2017 (13.03.2017) DO, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (25) Filing Language: English HN, KP, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (26) Publication Language: English MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (30) Priority Data: RU, 16382117.6 15 March 2016 (15.03.2016) EP TH, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (71) Applicant (for all designated States except US): F. HOFF- ZA, ZM, ZW. MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse (84) Designated States (unless otherwise indicated, for every 124, 4070 Basel (CH). kind of regional protection available): ARIPO (BW, GH, Applicant (for US only): HOFFMANN-LA ROCHE GM, INC. [US/US]; Overlook at Great Notch, 150 Clove Road TZ, (71) KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 8th Floor, Suite 8 - Legal Department, Little Falls, New TJ, Jersey 07424 (US). DK, LV, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, = = (72) Inventors: CICERI, Filippo; c/o Oryzon Genomics S.A., SM, C. Sant Ferran 74, 08940 Cornelia de Llobregat (ES). GW, KM, ML, MR, NE, SN, TD, TG). LUNARDI, Serena; c/o Oryzon Genomics S.A., C. Sant Ferran 74, 08940 Cornelia de Llobregat (ES). MAES, Published: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, = — — Tamara; c/o Oryzon Genomics S.A., C. Sant Ferran 74, — with international search report (Art. 21(3)) 08940 Cornelia de Llobregat (ES). MASCARO CRUS- _ = = = = = = = Title: COMBINATIONS OF LSD1 INHIBITORS FOR THE TREATMENT OF HEMATOLOGICAL MALIGNANCIES — (54) Il en N H2 11 (I) GC IN 11 in ,—, 1 40 1 IN 1-1 (57) : The instant invention relates to combinations of the compound of formula (I) or pharmaceutically acceptable salts 0 thereof with other active pharmaceutical ingredients (I), pharmaceutical compositions comprising them, and their use as medica- \" ments, particularly for the treatment of hematological malignancies.