baber/WOPTO huggingface dataset:
Patent DE-68928045-D1 (DE)
Inventor: CROSS PETER
IPC: C07D405/06
Filed: 1989-10-26
Granted: 1997-06-19
Abstract: A compound of the formula:- <CHEM>  or a pharmaceutically acceptable salt thereof,  wherein Y is a direct link, -CH2, -(CH2)2-, -CH2O- or -CH2S-;  R is -CN or -CONH2;  and R<1> is a group of the formula:- <CHEM> where R<2> and R<3> are each independently H, C1-C4 alkyl, C1-C4 alkoxy, -(CH2)nOH, halo, trifluoromethyl, cyano, -(CH2)nNR<4>R<5>, -CO(C1-C4 alkyl), -OCO(C1-C4 alkyl), -CH(OH)(C1-C4 alkyl), -C(OH)(C1-C4 alkyl)2, -SO2NH2, -(CH2)nCONR<4>R<5> or -(CH2)nCOO(C1-C4 alkyl);  R<4> and R<5> are each independently H or C1-C4 alkyl;  n is 0, 1 or 2;  X and X<1> are each independently O or CH2;  m is 1, 2 or 3;  and "Het" is pyridyl, pyrazinyl or thienyl. The compounds are muscarinic receptor antagonists useful in the treatment of diseases associated with the altered motility and/or tone of smooth muscle, especially irritable bowel syndrome.
Patent DE-69004023-D1 (DE)
Inventor: ABRAM TREVOR S
IPC: C07D257/04
Filed: 1990-07-14
Granted: 1993-11-25
Abstract: Aryl alkenoic acid derivatives, and physiologically acceptable salts thereof, are provided which are potent leukotriene antagonists and may be used for the treatment of circulatory diseases and preferably for respiratory diseases such as asthma. The derivatives have a general formula I <CHEM>  in which  X is -S-, -SO-, -SO2- or -O-;  W is CH=CH or CH2-CH2;  o is 1 to 5;  n is 1 to 10;  m is 0 to 7;  T and Z, same or different, represent oxygen or a direct bond; R<2> and R<3>, same or different, represent hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano or nitro groups; A represents carboxyl, tetrazolyl, CO2R<4>, CONR<5>R<6> or nitrile group wherein R<4> is lower alkyl and R<5> and R<6> are H, lower alkyl, alkylsulfonyl, arlysulfonyl or R5 and R6 together are an alkylene chain forming a ring; and  R is <CHEM>  wherein B represents carboxyl, tetrazolyl, CO2R<4>, CONR<5>R<6> or nitrile group wherein R<4> is lower alkyl and R<5> and R<6> are H, lower alkyl, alkylsulfonyl, arlysulfonyl or R5 and R6 together are an alkylene chain forming a ring;  R<7> and R<8>, same or different, represent H or lower alkyl;  R<9> represents -OH, -O-alkyl, NH2 or a NHCH2CO2H group; and R<1><0> is H, alkyl, alkoxy, halogen, CF3, CF3O, CN or NO2.
Patent DE-69004151-D1 (DE)
Inventor: ASAKURA SOTOO
IPC: A61K31/00
Filed: 1990-05-31
Granted: 1993-12-02
Abstract: A preparation for parenteral administration comprising FR115224 substance and cyclodextrin and process for preparing it.
Patent DE-69006360-D1 (DE)
Inventor: SCOLASTICO CARLO
IPC: C07F9/117
Filed: 1990-10-17
Granted: 1994-03-10
Abstract: PCT No. PCT/EP90/01757 Sec. 371 Date Mar. 2, 1992 Sec. 102(e) Date Mar. 2, 1992 PCT Filed Oct. 17, 1990 PCT Pub. No. WO91/06300 PCT Pub. Date May 16, 1991.Pharmaceutical compositions for the treatment of peripheral neuropathies of dysmetabolic or toxic origin and of cerebropathies of organic and functional origin, containing as the active ingredient L-(alpha)-glycerophosphoryl-D-myo-inosital, as such or as the alkali or alkali-earth metal salt thereof.
Patent DE-69008649-D1 (DE)
Inventor: MANFRONI EZIO
IPC: A23G9/08
Filed: 1990-06-28
Granted: 1994-06-09
Abstract: Machine for making ice-lollies on a small handicraft scale. The molds (3) for the ice-lollies are immersed in an unfreezable liquid contained in a tank (2) in heat-exchange relation with the evaporator (4) of a refrigerating unit (5,6,7). A circulating pump (10) circulates the cold unfreezable liquid in order to enhance the thermal exchange between a reservoir (8) of cold liquid and the freezing tank (2), through a flap valve (13). As soon as the ice-lolly mixture has frozen, a thermostat (20) disactivates the refrigerating unit (4,5,6,7) and stops the operation of the cold liquid circulating pump (10). Therefore, the cold liquid flows back into the cold liquid reservoir (8). On completion of this back-flow, a second circulating pump (16) is activated either manually or automatically to pump a hot liquid from a reservoir (9) having heating means (19), through the flap valve (13), into said tank (2) where ice-lollies have been formed, so as to cause said ice-lollies to be released from the molds (3). Thereafter, by disactivating the pump (16), the hot liquid is flowed back into its reservoir (9), and the cold liquid circulating pump (10) is re-started for a new ice-lolly making cycle.
Patent DE-69009685-D1 (DE)
Inventor: CHAN ALBERT SUN-CHI
IPC: A61K8/27
Filed: 1990-10-22
Granted: 1994-07-14
Abstract: A dentifrice composition is disclosed which contains dicalcium phosphate dihydrate and other common ingredients and a zinc sodium tripolyphosphate compound.
Patent DE-69016385-D1 (DE)
Inventor: ALBERTI GIULIO
IPC: G01N27/416
Filed: 1990-12-06
Granted: 1995-03-09
Abstract: A solid-state sensor for determining the concentration of gases which can react with hydrogen, in particular, of oxygen, is disclosed, which is essentially constituted by a solid-state proton conductor into contact: on the one side, with a reference electrode, constituted in its turn by a metal hydride or a metal alloy, and on the other side with an electrode which catalyses the reaction of the gas to be detected, with said sensor being connected with a power feed system which supplies current or voltage impulses, and with a system which detects the value of potential after each impulse.
Patent DE-69023487-D1 (DE)
Inventor: WHITE SPENCER
IPC: A43B7/20
Filed: 1990-02-08
Granted: 1995-12-14
Abstract: The present invention is directed to an article of footwear including an upper, a sole and a pumping chamber for producing a continuous supply of fluid. The sole includes a midsole and an outsole. The pumping chamber is formed between the bottom surface of the midsole and the upper surface of the outsole and includes at least one inlet and at least one outlet. Movement of the wearer's foot causes fluid to be drawn into and expelled from the pumping chamber. The fluid produced by the pumping chamber may be used to inflate an expandable bladder or to provide ventilation to the wearer's foot.
Patent DE-69029331-D1 (DE)
Inventor: THAKUR DEEPAK S
IPC: B01J37/03
Filed: 1990-10-15
Granted: 1997-01-16
Abstract: A process for preparing hydrogenation catalysts that comprise the oxides of copper, zinc and aluminium comprises the steps of (A) preparing a first aqueous solution containing at least one water-soluble copper salt and at least one water-soluble zinc salt; (B) preparing a second solution containing at least one water-soluble basic aluminium salt and at least one alkaline precipitating agent; (C) mixing the first and second solutions whereby an insoluble solid is formed; (D) recovering the insoluble solid; and (E) calcining the recovered solid.
Patent DE-69034238-D1 (DE)
Inventor: LE MOUELLIC HERVE
IPC: C12N5/10
Filed: 1990-03-19
Granted: 2007-05-24
Abstract: In a process for specific replacement of a gene, esp. by DNA targetting, the DNA being inserted consists of a part of a gene which can be made functional (or more efficient) when combined with complementary to form a complete recombinant gene in the genome of a eukaryotic cell. The new features are that (1) the insertion site is in a chosen receptor gene contg. the complementary gene; (2) eukaryotic cells are transfected with a vector contg. an insert consisting of the insert DNA and 2 flanking sequences homologous to two genomic sequences adjacent to the insertion site; (3) the inserted DNA is heterologous with respect to the receptor gene and (4) the flanking sequences make up complementary DNA so that, by homologous recombination with the corresp. sequences of the receptor gene, a complete gene is reconstructed in the genome of the eukaryotic cell. Also new are (1) plasmids for this process; (2) transformed eukaryotic cells and (3) transgenic animals in which one copy of a gene (oresent at least twice) has been inactivated by insertion of a different gene.
Patent DE-69103750-D1 (DE)
Inventor: STORM INGVAR
IPC: B66C1/36
Filed: 1991-05-16
Granted: 1994-10-06
Abstract: PCT No. PCT/SE91/00350 Sec. 371 Date Nov. 4, 1992 Sec. 102(e) Date Nov. 4, 1992 PCT Filed May 16, 1991 PCT Pub. No. WO91/18216 PCT Pub. Date Nov. 28, 1991.A safety hook comprising a curved hook body provided with a hook opening defined by a substantially U-shaped part and pivotally connected to a hook head which carries a pivotal shackle device, wherein the hook body, in a first open position, is held swung relative to the hook head so as to leave the hook opening open and therewith enable a load to be hooked onto the hook body, and wherein the hook body, in a second closed position, is swung relative to the hook head such that the hook opening is blocked by means of a barrier part which projects outwardly from the hook head, and wherein latching devices are provided for releasably securing the hook body essentially in the second position. The hook is mainly characterized in that the hook body is held in the first position by a spring force, in that the weight distribution on the hook is such that the opening defined by the U-shaped part is essentially horizontal in a vertical plane when the hook hangs substantially freely with no load thereon, and in that when the U-shaped part is subjected to a downwardly acting load, the U-shaped part is swung against a spring force towards and to the second closed position, the spring force striving to return the hook body to the first position.
Patent DE-69108908-D1 (DE)
Inventor: THOMPSON RAYMON
IPC: G11B7/26
Filed: 1991-04-24
Granted: 1995-05-18
Abstract: A wafer processor includes a portable processing head that can be a portable module or a movable unit mounted to a supporting machine frame. The processing head has movable fingers adapted to grip a wafer. The fingers protrude from a protective wafer plate. Indexing and rotation monitoring assemblies are provided for automation of the wafer processing steps. A complementary processing base includes an upwardly-open bowl that receives a wafer held by the portable processing head. It has a full-diameter movable bottom wall for rapid draining purposes. Liquid and/or gas jets and nozzles supply fluids required within the bowl for processing of wafers.
Patent DE-69110460-D1 (DE)
Inventor: STEVENS RODNEY
IPC: C07D311/58
Filed: 1991-04-18
Granted: 1995-07-20
Abstract: Compounds having the structure  <IMAGE>  wherein X is nitrogen, oxygen, sulfur or a bond and Z is oxygen or sulfur have been synthesized. These compounds are lipoxygenase inhibitors and are useful as the active agent in pharmaceutical compositions for treating inflammatory conditions in humans and other mammals for which lipoxygenase activity has been implicated.
Patent DE-69111792-D1 (DE)
Inventor: SZITA JENO G
IPC: C09D167/00
Filed: 1991-10-29
Granted: 1995-09-07
Abstract: Sulfonimide cure catalysts are used with aminoplast crosslinking agents and resins capable of reacting with aminoplast crosslinking agents to prepare heat curable compositions capable of crosslinking to form coatings and articles. Liquid or solid curable compositions may be prepared. Solid sulfonimide catalysts used in combination with solid glycoluril type crosslinking agents are well suited for powder coating systems containing hydroxy- and carboxy-functional resins.
Patent DE-69118129-D1 (DE)
Inventor: GIZUR TIBOR
IPC: A61K31/435
Filed: 1991-12-03
Granted: 1996-04-25
Abstract: The present invention relates to novel 1,2,3,6-tetrahydropyridine derivatives of the general formula (I) <CHEM>  - wherein  R stands for hydrogen or an alkyl group, X stands for an unsubstituted phenyl or benzyl group or for a phenyl or benzyl group substituted with a halogen atom,  Y stands for hydrogen or halogen or a trifluoro-methyl group -  as well as enantiomers acid addition salts thereof. The invention further extends to pharmaceutical compositions containing said compounds as active ingredient mainly for improving cerebral blood circulation and antihypoxic activity. The 1,2,3,6-tetrahydropyridine derivatives of the general formula (I) are prepared by treating an oxo derivative of the general formula (II) <CHEM> wherein R, X and Y are as given above in an organic solvent by a reducing agent and reacting the obtained 1,2,3,6-tetrahydropyridine derivative of the general formula (I), wherein R, X and Y are as given above, with a mineral or organic acid and converting the same, if desired, to an acid addition salt.
Patent DE-69123190-D1 (DE)
Inventor: NIADA RICCARDO
IPC: A61K9/127
Filed: 1991-07-15
Granted: 1997-01-02
Abstract: Recombinant hirudin can be effectively administered by the oral route in the form of suitable pharmaceutical compositions.
Patent DE-69123989-D1 (DE)
Inventor: THOLEN ANTONIUS HUBERTUS LOUIS
IPC: G11B27/10
Filed: 1991-03-08
Granted: 1997-02-20
Abstract: The disclosed combined recording and read device (24) comprises feeding means (21) for feeding edit data that denote passages (SK1, SK4) of the information recorded on a record carrier (1) of which reproduction is undesired, for example, as a result of possibly erroneously effected recordings. A Skip Table (Fig. 7, Fig. 8) representing these edit data is recorded on the record carrier (1). For the benefit of controlling the information that has been read out and recorded, the recording and read device (24) comprises means for reading the Skip Table prior to reading the recorded information. During the recording operation the passages indicated by the Skip Table are skipped. <IMAGE>
Patent DE-69124835-D1 (DE)
Inventor: LOIACONO DOMINIC N
IPC: C22C9/00
Filed: 1991-05-08
Granted: 1997-04-10
Abstract: Lead inclusion in copper-containing wrought alloys is coming into disfavor due to health and environmental considerations. Machinability, as well as retention of workability properties, associated with lead inclusion are assured by bismuth together with a modifying element, phosphorus, indium or tin. The modifying element minimizes the workability-precluding embrittlement otherwise caused by bismuth. The alloys are essentially of a stoichiometry and content of prototypical lead-containing alloy as specified as CDA 100-700 series wrought alloys in the 8th edition of the CDA Handbook of Wrought Products except that lead is replaced by bismuth within the weight percent range of 0.5-2 and that such composition invariably contains at least one of the third element additions in the weight percent ranges indicated; 0.1-0.5 P, 0.25-1.0 In, 0.5-6.0 Sn.
Patent DE-69129288-D1 (DE)
Inventor: BOUDET MICHEL
IPC: B01D53/04
Filed: 1991-10-11
Granted: 1998-05-28
Abstract: Process for separating at least one constituent of a gaseous mixture by adsorption, of the kind where the said gaseous mixture travels in a mass of adsorbent (16) of a plurality of adsorbent masses, with cyclic variation in pressure, the high pressure of the cycle being at least twice the low pressure of the cycle, characterised in that the adsorbent is arranged into a plurality of sectorial masses (11) distributed around and integrally attached to a support shaft (2) rotatable around an axis and in that a gas circulation is ensured in the adsorbent in the radial, centripetal or centrifugal direction, towards manifolds extending lengthwise, one situated on the radially inner side, the other situated on the radially outer side in relation to the said sectorial masses of adsorbent and in that a speed of rotation which is between approximately 2 and 20 revolutions/minute is ensured. 
<??>This process is intended particularly for the production of oxygen from air. 
<IMAGE>
Patent DE-69202309-D1 (DE)
Inventor: GAUTHERON MICHEL
IPC: F16D3/76
Filed: 1992-06-22
Granted: 1995-06-08
Abstract: Process for shaping, after moulding, at least one of the ends of the rigid inner bush (1) of a flexible joint having coaxial rings, characterised in that an annular allowance of material (overthickness) (6) is formed by local plastic deformation (creep) between half-dies which impose the external shape and by rivet die (snap) rocking about an oblique axis, of small-angle taper trajectory about the axis of the part, and in that the reaction is exerted on the opposite plane face of the rigid inner bush (1), without substantially stressing the elastomeric compound of the flexible sleeve (3), one of the plane end faces (5) of the said rigid inner bush (1) being capable of including at least one projecting element such as a cylindrical rib (18) or radial splines (fluting) (19). 
<??>Flexible joints produced according to this process. 
<IMAGE>
Patent DE-69206419-D1 (DE)
Inventor: CLEEF JEAN-FRANCOIS VAN
IPC: A61F2/02
Filed: 1992-07-16
Granted: 1996-01-11
Abstract: The intravenous device of the invention may be used to partially or totally flatten a vein. It is comprised of at least two bearing rods (1, 2) which are connected by at least one spreader element (3) having a spring effect and which are capable of bearing respectively on one and the other of two opposite edges of a vein. Said device (4) is substantially planar when it is positioned in the vein.
Patent DE-69210045-D1 (DE)
Inventor: BYRNE GERARD
IPC: B30B9/30
Filed: 1992-11-23
Granted: 1996-05-23
Abstract: PCT No. PCT/IE92/00024 Sec. 371 Date Jul. 21, 1994 Sec. 102(e) Date Jul. 21, 1994 PCT Filed Nov. 23, 1992 PCT Pub. No. WO93/09938 PCT Pub. Date May 27, 1993A waste compactor including an upwardly open waste container, and a roller mounted on a support for movement within the container to travel over waste in the container for compacting waste. The roller is movable up and down in the container as waste builds up in the container. The support includes a support arm slidably mounted on a support frame, the arm being inclined downwardly from the support frame towards the roller. For waste compaction a ram is operable to slide the arm on the support frame to urge the roller against the waste.
Patent DE-69213322-D1 (DE)
Inventor: STASKO WILLIAM
IPC: C22C38/00
Filed: 1992-02-19
Granted: 1996-10-10
Abstract: Prealloyed high-vanadium, cold work tool steel particles are provided for use in the powder-metallurgy production of tool steel articles. The particles are of a cold work tool steel alloy having an MC-type vanadium carbide dispersion of a carbide particle size substantially entirely less than 6 microns and in an amount of 18.5 to 34.0% by volume. The particles are produced by atomizing a molten tool steel alloy at a temperature above 2910 DEG F and rapidly cooling the atomized alloy to form solidified particles therefrom. The particles have the MC-type vanadium carbide dispersion therein. <IMAGE>
Patent DE-69217056-D1 (DE)
Inventor: BASTART JEAN-PIERRE
IPC: A61K47/44
Filed: 1992-07-03
Granted: 1997-03-06
Abstract: The invention relates to new compositions based on derivatives of the taxane class, consisting of solutions of these derivatives in a solvent mixture composed of ethanol and polysorbate. These solutions are used to prepare perfusions.
Patent DE-69230177-D1 (DE)
Inventor: BERNSTEIN STEVEN
IPC: G01N35/00
Filed: 1992-08-04
Granted: 1999-11-25
Abstract: A system which performs a plurality of independent analysis procedures simultaneously, possibly involving differing types of tissues and differing process steps, comprising a robotic device, which may cause the different tissue samples to be processed by processing stations, and a processor, which may select the next process step. The processor may direct the robotic device to interleave the differing process steps. The processor may select a next process step in response to timing information about the procedures, which may specify the start time and end time of each process step. The specified times may be exact or may be a range of times. The processor may determine the exact time for a step by generating a possible sequence of steps and examining that sequence for conflicts, adjusting that sequence in response to those steps with a specified range of times, and iterating the calculation over a plurality of possible sequences. The processor may also optimize the order in which process steps are performed to minimize the total time required by the system to complete the procedures, for example by generating a plurality of possible sequences, evaluating each sequence for total expected time, and selecting the best sequence available.
Patent DE-69301466-D1 (DE)
Inventor: LAMBERT JOHN
IPC: F02B43/00
Filed: 1993-06-24
Granted: 1996-03-14
Abstract: A carburetor assembly having a venturi element for fuel metering and a throttle valve for controlling the flow of an air and natural gas mixture to the combustion chamber of an internal combustion gas engine wherein a stepper motor is used to angularly position a throttle valve plate in the gas flow path to the carburetor, the throttle valve plate being carried on a throttle valve shaft that forms an extension of the armature of the stepper motor wherein provision is made for sealing the stepper motor at a location on the axis of rotation of the throttle valve element, the throttle valve shaft being mounted without the necessity for using throttle valve shaft bearings or a separate seal, thereby minimizing friction and any tendency for a misalignment to occur.
Patent DE-69303588-D1 (DE)
Inventor: TOUZAN PHILIPPE
IPC: A61K8/03
Filed: 1993-12-17
Granted: 1996-08-14
Abstract: Cosmetic or dermatological composition provided in two-phase form.  , is non-foaming composition consists of an aqueous phase and of a separate oily phase in a ratio between 30/70 and 60/40, at least one of the said phases containing a surface-active agent in an amount greater than 0.25% by weight, the said aqueous phase containing a dephasing agent in an amount between 0.025% and 0.5% by weight, the said agent being an alkyldimethylbenzylammonium chloride of formula: <IMAGE>  in which: R represents a saturated linear alkyl radical essentially containing from 12 to 16 carbon atoms. This composition may be used for any cosmetic or dermatological purpose and in particular for removing make-up from the eyes or the face, in a sun lotion or in a skin cleaning or skin care lotion.
Patent DE-69304209-D1 (DE)
Inventor: MARTIN NATHALIE
IPC: C02F1/72
Filed: 1993-11-24
Granted: 1996-09-26
Abstract: PCT No. PCT/FR93/01155 Sec. 371 Date May 23, 1995 Sec. 102(e) Date May 23, 1995 PCT Filed Nov. 24, 1993 PCT Pub. No. WO94/12437 PCT Pub. Date Jun. 9, 1994A plant for processing untreated water, particularly drilling water, to at least partially remove mircopollutants thereform. The plant includes at least one main feed pipe for feeding water into the bottom of a reactor via a submerged inlet at end of said main pipe for delivering ozone into the water, a means communicating with said main pipe for delivering hydrogen peroxide into the water, at least one liquid gas transfer system including at least one static mixer downstream from said ozone delivery means and said hydrogen peroxide delivery means, and upstream from said reactor; and a means for evenly distributing the flow of water out of said feed pipe and through the inlet and allowing a drop in the kinetic energy of the water as it enters said reactor.
Patent DE-69307787-D1 (DE)
Inventor: KOSMYNA MICHAEL J
IPC: B01D46/40
Filed: 1993-06-23
Granted: 1997-03-13
Abstract: A disposable air filter is described including a filter element (24) formed from a stacked plurality of annular disks (25). The disks (25) are formed from a sorptive material and expand upon absorption of oil or water droplets. The disks (25) are slightly compressed by a movable baffle (28). The baffle (28) floats upon a stream of air entering the filter and directs the air radially through the filter element (24). The air flows between and through the disks (25) with a resulting low pressure drop across the filter. As the disks (25) expand, the baffle (28) shifts axially within a filter housing (11) to maintain the pressure drop across the filter element.