Patent SG-11201901233S-A (SG)
Title: Purification systems and methods
Inventor: SCHULZ CRAIG MICHAEL
IPC: G01N33/543
Filed: 2017-10-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property ::::` , 11111 11111011101111011111 0110 1 0 011111111111110111111 1011 00 WO 11 0111111 Organization International Bureau (10) International Publication Number 03 (43) International Publication Date ......°' WO 2018/080953 Al 03 May 2018 (03.05.2018) W I P0 I P C T (51) International Patent Classification: (72) Inventors: SCHULZ, Craig Michael; 397 Pepperwood G01N 33/543 (2006.01) BO3C 1/10 (2006.01) Ct., Thousand Oaks, CA 91390 (US). PROVCHY, Justin B03C 1/01 (2006.01) B03C 1/12 (2006.01) James; 1732 Sitka Ave., Simi Valley, CA 93063 (US). KA- WOOYA, John Kasajj a; 12565 Spring Creek Road, Moor- (21) International Application Number: PCT/US2017/057788 park, CA 93021 (US). (22) International Filing Date: (74) Agent: CHAVKA, Daniel T.; Marshall, Gerstein & Borun 23 October 2017 (23.10.2017) LLP, 233 S. Wacker Drive, 6300 Willis Tower, Chicago, IL 60606-6357 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of national protection available): AE, AG, AL, AM, (30) Priority Data: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 62/415,448 31 October 2016 (31.10.2016) US CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (71) Applicant: AMGEN INC. [US/US]; One Amgen Center HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, Drive, Thousand Oaks, CA 91320-1799 (US). KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (54) Title: PURIFICATION SYSTEMS AND METHODS = = A- 24 / I 46 10 40 48 16 = 0 56 _ 22d 44 14 28b ib ilbti a ._ - '' 20d artml ,28a -4/ . 17 . 1 .— / 4 lib ./,‘ 43d 1111r , _ c.11. 4to isb,/ bp OA '12 52 REPALWilail lip allra 4 12 0 = _ .-. - 4 - 50 = 20c Allpicibmittabt 111/ ......,.._ mimmmmmfegtqlrSf=Zr(a, I 22c •Wall IMEIMPRIP-i`\•::.-- = .111 411 Wir t ip 1 ' I 22a = I 20a 43c = 50 4., 100 / 43a 12 -----__, = — D // 20b 41 / 43b 22b = — = FIG. 2 1-1 (57) : A purification system and method may include a container receiving portion, pump, and magnetic field generating r r ? element. The container receiving portion may be configured to receive and support a container containing a mixture. Magnetic beads i 1r 4 may be added to the container for separating a target substance from a remainder of the mixture. The magnetic field generating element 01 cz may be movable relative to the container receiving portion between a non-working position remote from the container receiving portion GA and a working position adjacent an outer periphery of the container receiving portion. In the working position, the magnetic field • -.., © generating element may attract the magnetic beads and hold them firmly against an interior surface of the container. While the magnetic GC beads are immobilized by the magnetic field generating element, the pump may remove the mixture from the container, leaving behind 1-1 c: : :: , the magnetic beads bound tightly but reversibly to the target substance. ei O [Continued on next page] WO 2018/080953 Al MIDEDIMOMOIDEIREEMOOMMMOIRIBEININVOIS SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))