baber/WOPTO huggingface dataset:
Patent EP-0874633-A1 (EP)
Inventor: DORGAN RODERICK JOHN
IPC: A61K31/537
Filed: 1996-10-31
Abstract: L'invention concerne des composés de formule (I) dans laquelle R1 est un groupe ester pharmaceutiquement acceptable hydrolysable in vivo. Ces composés peuvent s'utiliser pour traiter ou prévenir une infection bactérienne chez un animal par administration par voie orale.
Patent EP-0934271-A1 (EP)
Inventor: REICHARD GREGORY A
IPC: A61P43/00
Filed: 1996-10-28
Abstract: Aralkylamine derivatives of formula (I) and their salts are new: A1 = CH2R6, OR6, NR6R7, SOeR13, (CR6R7)qOR6, (CR6R7)qNR6R7 or (CR6R7)qSOeR13; q = 1-6; A2 = H; or A1+A2 = O, CR6R7, NOR6 or S; Q = R5-phenyl, R5-naphthyl, SR6, NR6R7, OR6 or R5-heteroaryl; T = H, R4-aryl, R4-heterocycloalkyl, R4-heteroaryl, R4-cycloalkyl or R10-bridged cycloalkyl; b = 0-2; b1 = 1-2; X = a bond, CO, O, NR6, SOe, NR6CO, CONR6, OC(O)NR6, OC(S)NR6, NR6C(S)O, C(=NOR6), SO2NR6, NR6SO2, NR6CO2 or OC(O); R4, R5 = 1-3 of H, halo, OR6, OC(O)R6, OC(O)NR6R7, NR6R7, 1-6C alkyl, CF3, C2F5, COR6, CO2R6, CONR6R7, SOeR13, CN, OCF3, NR6CO2R16, NR6COR7, NR8CONR6R7, R15-phenyl, R15-benzyl, NO2, NR6SO2R13 or SO2NR6R7; or adjacent R4 substituents or adjacent R5 substituents can form OCH2O; or R4 = R15-heteroaryl; R6, R7, R8, R8a, R13 = H, 1-6C alkyl, 2-6C hydroxyalkyl, 1-6C alkoxy-1-6C alkyl, R15-phenyl or R15-benzyl or NR6R7 = 5-6 membered ring containing 1-2 of O, S and/or NR19; R9, R9a = R6 or OR6; provided that when R9 = OH, then X = a bond, CO, NR6CO or C(=NOR6); R10 = H or 1-6C alkyl; R15 = 1-3 of H, 1-6C alkyl, 1-6C alkoxy, 1-6C alkylthio, halo, CF3, C2F5, COR10, CO2R10, CON(R10)2, SOeR10, CN, N(R10)COR10, N(R10)CON(R10)2 or NO2; R16 = 1-6C alkyl, R15-phenyl or R15-benzyl; R19 = H, 1-6C alkyl, CON(R10)2, CO2R10, (CR8R9)fCO2R10 or (CR8R9)uC(O)N(R10)2; f = 1-6; u = 0-6; Z = a group of formula (a)-(c): g, j = 0-3; h, k = 1-4, provided that h +g = 1-7; J = (H, H), O, S, NR9 or NOR9; L, L1 = H, 1-6C alkyl, 1-6C alkenyl, CH2-cycloalkyl, R15-benzyl, R15-heteroaryl, COR6, (CH2)mOR6, (CH2)mNR6R7, (CH2)mCO2R6 or (CH2)mCONR6R7; m = 0-4; provided that when j = 0 then m = 1-4; R25 = H, 1-6C alkyl, CN, R15-phenyl or R15-benzyl; R26, R27 = H, 1-6C alkyl, R4-aryl or R4-heteroaryl or R26 = H, 1-6C alkyl, R4-aryl or R4-heteroaryl and R27 = COR6, CONR6R7, COR4-aryl, COR4-heteroaryl, SO2R13 or SO2R4-aryl; R28 = H, (CR6R19)tG or (CR6R7)vG2; t, v = 0-3; provided that when j = 0 then t = 1-3; R29 = H, 1-6C alkyl, C(R10)2SOeR6, R4-phenyl or R4-heteroaryl; G = H, R4-aryl, R4-heterocycloalkyl, R4-heteroaryl, R4-cycloalkyl, OR6, NR7R6, COR6, CO2R6, CONR7R9, SOeR13, NR6CO2R16, NR6COR7, NR8CONR6R7, NR6SO2R13, SO2NR6R7, OC(O)R6, OC(O)NR6R7, C(=NOR8)NR6R7, C(=NR25)NR6R7, NR8C(=NR15)NR6R7, CN, C(O)NR6OR7 or C(O)N(R9)-(R4-heteroaryl), provided that when n = 1 and u = 0 or when R9 = OR6 then G is not OH or NR6R7 and G2 = R4-aryl, R4-heterocycloalkyl, R4-heteroaryl, R4-cycloalkyl, COR6, CO2R16, SO2NR6R7 or CONR6R7. 15 Compounds (I) are specifically claimed e.g: N-(2-(3,4-dichlorophenyl)-3-hydroxy-4-(4-hydroxy-4-phenyl-1-piperidinyl)butyl)-N-methyl benzamide.
Patent EP-0858530-A1 (EP)
Title: Feuilles realisees a partir de papier renfermant des fibres d'ester de cellulose
Inventor: ELLERY ERIC EUGENE
IPC: D21H13/06
Filed: 1996-10-30
Abstract: Feuille thermoplastique constituée d'un mélange de 20 à 85 % en poids de fibres d'ester de cellulose et de 80 à 15 % en poids de fibres de cellulose et d'une quantité suffisante d'un plastifiant à esters de cellulose. Cette feuille présente un opacité comprise entre 10 et 85 %, une épaisseur comprise entre 0,05 et 0,25 mm, une porosité comprise entre 0,0 et 50 ml/min/cm2 pour une chute de pression de 1,0 centibar, et une compostabilité de moins de 65 jours de fragmentation. Afin de préparer ladite feuille, on réalise un papier constitué de 20 à 85 % en poids de fibres d'ester de cellulose et de 80 à 15 % en poids de fibres de cellulose, et on sature le papier d'une quantité suffisante d'un plastifiant à esters de cellulose. On soumet le papier saturé à l'action de la chaleur et de la pression pendant une durée déterminée afin d'obtenir la feuille thermoplastique. On prépare cette feuille thermoplastique sans utiliser de solvants, et elle est intéressante sur le plan économique car elle est compatible avec les produits et techniques traditionnels de l'impression sur papier.
Patent EP-0809519-A1 (EP)
Inventor: TOURNIER HERVE
IPC: A61K49/04
Filed: 1996-12-19
Abstract: The invention relates to non-ionic triiodo aromatic compounds and compositions comprising triiodo aromatic polymers useful for X-ray imaging of gastro-intestinal tract. Disclosed compounds are acrylic acid esters of triiodobenzenes with a different degree of reticulation and their polymers/homopolymers. A method of making the polymers, method of making X-ray contrast agents using the polymers and use of the contrast agents is also disclosed.
Patent EP-0868423-A1 (EP)
Inventor: GUSTAVSSON ANDERS
IPC: C07D401/12
Filed: 1996-12-05
Abstract: Procédé d'élaboration d'omeprazole à partir d'alcool pyrméthylique par l'intermédiaire de chlorure pyrméthylique et de pyrmétazole. Le procédé se caractérise par le fait que la séquence de réaction s'effectue dans son ensemble sans aucun isolement ni aucune purification des intermédiaires. La réaction s'effectue en outre dans un système solvant principal commun à la totalité de la séquence et inerte pour les réactifs se formant en cours d'opération et utilisés dans le cadre de ce procédé. Ce procédé peut également inclure une étape suppémentaire de purification.
Patent EP-0879501-A1 (EP)
Inventor: MOTOROLA INC
IPC: H01P5/12
Filed: 1996-08-12
Abstract: L'invention porte sur un procédé de prévention et/ou de traitement de lésions cutanées, notamment de l'inflammation ou du vieillissement. Une composition contenant de l'acide lipoïque et/ou un dérivé d'acide lipoïque est appliquée sur les zones de peau touchées. Un ester acide gras liposoluble d'acide ascorbique, tel que de l'ascorbate palmitique et/ou du tocotriénol, est de préférence appliqué conjointement à l'acide lipoïque, ou l'un de ses dérivés, et à un excipient dermatologiquement acceptable.
Patent EP-0791342-A1 (EP)
Inventor: GRUNDEI HANS DR
IPC: A61F2/36
Filed: 1997-01-07
Abstract: A femur endoprosthesis for an artificial hip joint includes (a) a shell (1) which can be implanted without cement in the upper region of a femur below the greater trochanter, the proximal end (8) of the shell being connectable with an adapter (2) for accommodating an artificial spherical joint part (20), wherein the exterior of the shell is at least partially covered with an open-meshed three-dimensional spatial lattice structure (9), and (b) a draw plate (3) in which a draw-in screw (4) can be fastened, which can be inserted in the interior of the shell through a through bore (5) in its distal end (6), and which can be screwed in with a thread (7) provided therein.
Patent EP-0856521-A1 (EP)
Inventor: NONAKA SHIN-ICHI
IPC: C08F4/40
Filed: 1997-01-31
Abstract: The description relates to an initiator composition for
polymerising unsaturated monomers, containing a mixture
component (A) of
   i) at least one salt of a metal in the second sub-group
of the periodic system, optionally in solution in an
aromatic solvent or in an α,β-unsaturated ester, and   ii) at least one salt of a metal in the seventh or eighth
sub-group of the periodic system, optionally in
solution in an aromatic solvent or in an α,β-unsaturated
ester, and  
at least one organic peroxy ester (component B) 
wherein the components (A) and (B) are spatially adjacent
to one another. 
     The description also relates to polymerisable compositions
comprising the said initiator composition together with
polymerisable unsaturated monomers. The initiator
composition according to the invention can be used to
homopolymerise and copolymerise all kinds of unsaturated
monomers, such as methacrylic and acrylic acid esters, at
lower temperatures.
Patent EP-0797211-A1 (EP)
Inventor: ICHIMURA TOORU
IPC: G11C7/12
Filed: 1997-02-27
Abstract: A semiconductor memory device includes: subarrays (1) having memory cells (511-514, 521-524) each arranged at cross points of a plurality of bit lines (Bn,            Bn     ¯            (n = 1-4)) and a plurality of word lines (WL0-WL255); a row decoder (2) for selecting among the word lines (WL0-WL255); a column decoder (3) for supplying a select signal to transfer gates (61-64, 71-74) for selecting among paired bit lines (Bn,            Bn     ¯            (n = 1-4, 10, 20, 30, 40)); and a clamping circuit (8) for fixing the potential of a column select line at a constant potential before the column decoder is activated.
Patent EP-0802001-A1 (EP)
Inventor: ALLEMANN MARCO
IPC: B21D39/02
Filed: 1997-03-20
Abstract: An einer Maschine zum Umbiegen eines an einem ersten Blechteil (2) vorgesehenen Blechrandes (4) zu einem mit dem ersten Blechteil (2) zu verbindenden zweiten Blechteil (3) mit wenigstens einem vorzugsweise angetriebenen Formrollenpaar (12,15), dessen Formrollen (13,14,16,17) in Vorschubrichtung (19) an einander gegegenüberliegenden Seiten des Blechrandes (4) auf diesem entlang seiner Längskante abrollen und dessen Rollenspalt (20,22) in Biegerichtung zu dem zweiten Blechteil (3) hin geneigt ist, wobei eine der Formrollen (14,17) den Blechrand (4) an dessen dem zweiten Blechrand (3) zugewandten Seite untergreift, sowie mit einer quer zu der Vorschubrichtung (19) wirksamen Abstützung mit wenigstens einem sich an einem der Blechteile (2,3) abstützenden Widerlager ist vorgesehen, daß das (die) Widerlager dem Formrollenpaar (12) in Vorschubrichtung (19) nacheilend angeordnet ist (sind) und sich an der dem zweiten Blechteil (3) zugewandten Seite des Blechrandes (4) abstützt (abstützen). Unerwünschte Deformierungen und Beschädigungen der Blechteile (2,3) werden dadurch vermieden. <IMAGE>
Patent EP-0884629-A1 (EP)
Inventor: MATSUMOTO FUMIHARU
IPC: G03B17/24
Filed: 1997-10-10
Abstract: The present invention provides a camera having character display capability for
producing photographs having a large subject area and a smaller distinct border area
for characters, words or symbols. The camera incorporates an exposure chamber
divided into two light-tight sections by a light shield which may be integrally molded.
One of the sections contains an artificial light generating source to expose characters
placed on a transparent film onto the character area of the film frame. The other
exposure chamber section is open to the camera lens and exposes the subject of the
photograph onto a subject area of the film frame. The artificial light generating source
may comprise an electronic strobe flash and may share its power source and circuitry
with the external camera flash used to illuminate the subject of the picture. When
employed in a disposable camera, the invention facilitates the use of recyclable parts
and is generally simple and economical to manufacture.
Patent EP-0841467-A1 (EP)
Inventor: SCHAEFF HANS
IPC: E21C31/02
Filed: 1997-10-29
Abstract: Rock cutting head comprising a one-part steel housing attachable to a working machine lug, an electric or hydro motor being attached to the rear portion of the housing and two uni-axial similar cutting drums being provided at its front portion, the rear housing portion, in which a drive pinion directly or indirectly connected to the motor is provided, being terminated toward the lug with a widened connection plate, its front portion supporting outer bearing hubs, in which the shafts of the two cutting drums uniformly connected to a middle drive spur-toothed wheel are provided and wherein a larger intermediate wheel is provided in the housing between drive pinion and drive spur-toothed wheel.
Patent EP-0795327-A1 (EP)
Inventor: CROPP ANNE B
IPC: A61K38/55
Filed: 1997-03-05
Abstract: This invention relates to a method for reducing morbidity and/or mortality in a mammal with congestive heart failure due to non-ischemic etiology comprising administering amlodipine or a pharmaceutically acceptable amlodipine acid addition salt, and, optionally, a diuretic and/or digoxin. The invention further relates to methods for treating patients with congestive heart failure due to non-ischemic etiology, comprising administering a non-ischemic congestive heart failure treating amount of amlodipine or a pharmaceutically acceptable amlodipine salt and, optionally, a diuretic and/or digoxin. The invention also provides a kit which comprises a container means and a) amlodipine and a diuretic, b) amlodipine and digoxin, or c) amlodipine, digoxin and a diuretic; and a kit which comprises a container means and a) amlodipine, an angiotensin converting enzyme (ACE) inhibitor and a diuretic, b) amlodipine, an ACE inhibitor and digoxin, or c) amlodipine, an ACE inhibitor, digoxin and a diuretic. Further, this invention relates to compositions comprising amlodipine or a pharmaceutically acceptable salt thereof and one or both of digoxin and/or a diuretic.
Patent EP-0817049-A1 (EP)
Inventor: SUMI FUMIO
IPC: G06F11/28
Filed: 1997-03-27
Abstract: A program development system in which the debugging
apparatus is informed of all of the optimization processes
which have been performed. A primitive storage unit stores
record information for the optimization processes. The
input unit receives an input of a variable and a value, or
an input of a line where execution is to be halted. The
primitive combining unit obtains record information showing
the optimization processes. The code execution unit
executes the execution code. The variable operation unit
obtains the value of a variable based on relations between
variables and resources. The output unit displays the
obtained value of the variable. The line display unit
displays the program or the generated execution code. The
line information display unit displays, in line units,
information relating to the optimization performed for each
line. The operation-possible variable display unit
displays, for each line, variables which can be set and
referred to in the line. The optimization process display
unit shows how the optimization affects each variable.
Patent EP-0812580-A1 (EP)
Inventor: STOECKEL DIETER
IPC: A61F2/00
Filed: 1997-06-12
Abstract: A stent which comprises a plurality of aligned hoop portions in which adjacent hoop portions are connected to one another by means of struts. The spacing between the hoop portions varies along the length of the stent. The struts between one hoop portion and its neighbouring hoop portion on one side, which together form a first hoop portion pair, are offset circumferentially relative to the struts between the said one hoop portion and its neighbouring hoop portion on the other side which together form a second hoop portion pair.
Patent EP-0893417-A1 (EP)
Inventor: KOMIYA HIDETOSHI
IPC: C03C3/078
Filed: 1997-07-21
Abstract: In a method of producing a crystal glass
composition which employs TiO 2  as a raw material
substituted for PbO, to a hatch composition which is
composed of 50 to 60 percent by weight of SiO 2 , 4 to 14
percent by weight of K 2 O, 10 to 20 percent by weight of
BaO and 3 to 10 percent by weight of TiO 2 , NaNO 3  (sodium
nitrate) is added by 1.0 to 5.0 percent by weight or
BaO 2  (barium peroxide) is added by 0.3 to 2.0 percent by
weight for elimination of development of a color which
arises from the 3 to 10 percent by weight of TiO 2 , and
also one of Sb 2 O 3  (antimony oxide) and As 2 O 3  (arsenious
acid) is added by 0.2 to 1.0 percent by weight for
defoaming. Instead, NaSb(OH) 6  (sodium antimonate)
having color development elimination and defoaming
actions may be added by 0.5 to 2.0 percent by weight.
Patent EP-0885563-A1 (EP)
Inventor: FOCHEUX CATHERINE
IPC: A01N53/00
Filed: 1997-06-18
Abstract: A repellent solid pest control system which includes a
polymeric matrix, a liquid plasticizer, a pest control active
ingredient and triphenyl phosphate as a carrier for the
active ingredient. Protection of dogs from bites of
phlebotomine sandflies by using systems according to the
inventor for the control of canine leishmaniasis.
Patent EP-0974350-A1 (EP)
Inventor: MORI MASAO
IPC: A61K31/196
Filed: 1997-02-06
Abstract: An external preparation containing tranilast which is
excellent in the release of the active ingredient contained
therein, achieves a high percutaneous absorption, fully
ensures the effective drug concentration in the skin tissue
and little irritates the skin. This preparation is composed of
an aqueous base containing as the active ingredient tranilast,
its salt or a mixture thereof. The aqueous base contains a
solubilizer for tranilast, a dispersant, an absorption aid, an
adhesive and/or a shape retenting agent, and water. The active
ingredient has been solubilized by the above-mentioned
solubilizer and dispersed in the aqueous base by the above-mentioned
dispersant.
Patent EP-0949083-A1 (EP)
Inventor: ONO KAZUYASU
IPC: B41J29/38
Filed: 1997-10-29
Abstract: A printer 80 integrally comprises a printing section 81
for printing on a recording medium such as a cut sheet S and
continuous paper L2 based on printing data transmitted from
an external host unit H, a control panel 70 containing an
indicator section for indicating operating states of the
printing section 81, a display panel 60 for displaying data
transmitted from the host unit H to the printing section 81
and instructed to be displayed, an interface 86 for
transmitting/receiving signals between the host unit H and the
printing section 81 and interfaces 87 and 62 for
transmiting/receiving signals between the printing section 81
and the display panel 60. It is possible to securely prevent
disagreement of printed content and displayed content and to
realize down-sizing and simplification of the system structure
by constructing as described above.
Patent EP-0941348-A1 (EP)
Inventor: KO KENTON
IPC: C12N5/10
Filed: 1997-11-04
Abstract: L'invention a trait à une nouvelle technique d'amélioration de la translocation de molécules à travers des membranes cellulaires ou à l'intérieur de celles-ci, laquelle technique fait intervenir un gène de transport de protéine de plaste. Il est également possible d'utiliser cette technique pour introduire des substances à l'intérieur des membranes d'organismes. Des produits de recombinaison d'acide nucléique comprennent ceux qui expriment une protéine de transport de protéine de plaste ou son équivalent dans les cellules de tous organismes.
Patent EP-0935441-A1 (EP)
Title: Procede et dispositif servant a cartographier les synapses corticales
Inventor: ILMONIEMI RISTO
IPC: A61B5/0484
Filed: 1997-10-30
Abstract: L'invention concerne un procédé et un dispositif servant à examiner et à cartographier la réactivité de différentes zones corticales, ainsi que les synapses entre lesdites zones. Ce procédé consiste à induire une excitation électromagnétique dans les parties intérieures de la tête et à mesurer le champ électromagnétique généré autour du crâne en utilisant des moyens électriques (1). D'après ce procédé, on mesure l'activité électromagnétique du cerveau au moyen d'un équipement à canaux multiples, on élimine les phénomènes parasites provoqués par l'excitation du signal contenant l'activité électromagnétique, on crée une visualisation des changemetns d'activité dans les signaux mesurés et on localise les zones de la tête relatives à ladite activité générant ledit champ électromagnétique ou, dans un autre mode de réalisation, on focalise sur un point souhaité le maximum de la configuration de sensibilité du système de mesure d'activité à canaux multiples.
Patent EP-0939996-A1 (EP)
Inventor: MERCKE JOHAN
IPC: H02J7/00
Filed: 1997-11-11
Abstract: A battery pack (40) for a portable electric apparatus (20) has one or more than one battery cells (41a, 41b) and terminals for electric connection to the apparatus. The battery pack (40) comprises a first terminal (43) for receiving charging current from the apparatus (20), a second terminal (44) for feeding supply current to the apparatus, and a third terminal (45) for establishing a zero or ground line common to the apparatus and the battery pack. Furthermore, the battery pack comprises a first voltage converting means (50), which is arranged between the first terminal (43) and the battery cell(s) (41a, 41b), and a second voltage converting means (60), which is arranged between the second terminal (44) and the battery cell(s).
Patent EP-0891534-A1 (EP)
Title: Mass flow transducer having extended flow rate measurement range
Inventor: LUCAS PAUL D
IPC: G01F5/00
Filed: 1997-04-03
Abstract: The transducer (10) has a single laminar flow element (24) in a primary fluid flow path (14) and multiple secondary flow paths (16) in parallel with and in fluid communication with the primary flow path. An electric circuit (18) is coupled to each of the multiple secondary flow paths for measuring the corresponding flow rate in the primary flow path as a function of temperature of the fluid flowing in the secondary flow paths. A circuit (18) is coupled to each of the secondary flow paths includes at least one temperature responsive element (20) in thermal communication with the fluid in the corresponding secondary flow path.
Patent EP-0904051-A1 (EP)
Inventor: FAENGER SABINE
IPC: A61K47/36
Filed: 1997-04-24
Abstract: PCT No. PCT/EP97/02091 Sec. 371 Date Nov. 6, 1998 Sec. 102(e) Date Nov. 6, 1998 PCT Filed Apr. 24, 1997 PCT Pub. No. WO97/44009 PCT Pub. Date Nov. 27, 1997Cosmetic or pharmaceutical preparations, characterized in that they comprise an effective concentration of hydrophilic starch esterified with one or more n-octenylsuccinate radicals.
Patent EP-0907829-A1 (EP)
Inventor: HAYS LANCE G
IPC: F04D1/12
Filed: 1997-06-26
Abstract: La présente invention concerne un appareil de turbine rotative comprenant un séparateur et possédant une paroi cylindrique rotative recevant un flux de liquide et de gaz. Ladite turbine est destinée à la séparation du gaz et du liquide, ledit liquide s'accumulant dans un anneau tournant de la paroi. L'appareil comporte un diffuseur (14) ayant une prise (15) immergée dans l'anneau à rotatif pour recevoir le liquide de l'anneau (13) et une structure de barrière (21) située à proximité de la prise du diffuseur pour empêcher l'entrée de gaz dans le diffuseur.
Patent EP-0958376-A1 (EP)
Inventor: ROTHSCHILD MAX F
IPC: C12Q1/68
Filed: 1997-06-30
Abstract: Disclosed herein are genetic markers for pig litter size, methods for identifying such markers, and methods of screening pigs to determine those more likely to produce larger litters and preferably selecting those pigs for future breeding purposes. The markers are based upon the presence or absence of certain polymorphisms in the pig prolactin receptor gene.
Patent EP-0963180-A1 (EP)
Inventor: YOUNG RODERICK A
IPC: A61M29/02
Filed: 1997-06-30
Abstract: A combination tissue dissector and long term expander is disclosed for use in plastic surgery applications and other applications where it is desirable to dissect a tissue pocket and serially expand the dissected pocket through long term tissue expansion. The combination device performs the separate functions of dissection and long term expansion in a single balloon package. In an exemplary embodiment, three sheets of substantially inelastic material are bonded together at their outer margins to form two discrete inflatable chambers. The lower inflatable chamber defined by the middle and lower balloon sheets is further welded together at various points over the sheet's surface area to create a semi-rigid base portion which provides a flat well-defined footprint for the balloon. The semi-rigid base prevents further enlargement of the tissue pocket at the margins when the device is utilized as a tissue expander. In a preferred method of use for the combination device, the combination device is tunneled bluntly to a desired location within the body. The device is then inflated to dissect tissue layers along natural tissue planes and create a tissue pocket. After dissection, the combination device may be left within the body as a temporary implant to further expand the tissue pocket through long term expansion until the desired tissue pocket volume is achieved.