Patent CA-3015375-A1 (CA)
Title: Process and system for predicting responders and non-responders to mesalamine treatment of ulcerative colitis
Inventor: YACYSHYN BRUCE R
IPC: G01N33/50
Filed: 2017-03-13
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY  (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date                 WO 2017/160675 Al 21 September 2017 (21.09.2017) WIPO I PCT (51) International Patent Classification:                                          AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, G01N 33/50 (2006.01)    G01N 33/96 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, G01N 33/564 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (21) International Application Number:                                             KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, PCT/1J52017/022013                      MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (22) International Filing Date:                                                    NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 13 March 2017 (13.03.2017)              RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (25) Filing Language:                     English    ZA, ZM, ZW. (26) Publication Language:                                                         English (84) Designated States (unless otherwise indicated, for every (30) Priority Data:                                                                kind of regional protection available): ARIPO (BW, GH, 15/068,981       14 March 2016 (14.03.2016) US    GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) Inventors; and TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (71) Applicants : YACYSHYN, Bruce [US/US]; 7662 Cold-    DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, stream Drive, Cincinnati, OH 45255 (US). YACYSHYN,    LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Mary, E. [US/US]; 7662 Coldstream Drive, Cincinnati,    SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, OH 45255 (US).                                GW, KM, ML, MR, NE, SN, TD, TG).    (74) Agent: SMITH, Mark, F.; 905 Ohio Pike, Cincinnati, OH Declarations under Rule 4.17: 45245 (US). ¨                                             of inventorship (Rule 4.17(iv)) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, [Continued on next page] (54) Title: PROCESS AND SYSTEM FOR PREDICTING RESPONDERS AND NON-RESPONDERS TO  MESALAMINE  TREATMENT OF ULCERATIVE COLITIS (57) Abstract: A process and system directed to a more effective, individual based treatment regimen which is built on clinical identified target biomark-FIG. 1 ers associated with gender differential responses to mesalamine, and includes PATIENT                                                                            one or more panels of target biomarkers that distinguishes mesalamine re-sponse differences between genders and determines the efficacy of mesalam-\ BLOOD SAMPLE \.                                                                    ine for patients being treated for various UC conditions and effectively iden-titles and validates novel drug targets for new UC therapeutics, new dia-gnostics and diagnostics standards for UC therapeutic strategies. SELECTED TUBE(S) SEPARATOR(S) BLOOD COMPONENT   PANELS   TARGET EllOMARKERS     WO 2017/160675 Al 1111011110111010101H010111011101111001101100M0V0l ll Published: ¨    with international search report (Art. 21(3))