Patent SG-11201807523P-A (SG)
Title: Ilt7 binding molecules and methods of using the same
Inventor: VOUSDEN KATHERINE
IPC: C12P21/08
Filed: 2017-03-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/156298 Al 14 September 2017 (14.09.2017) WIPO I PCT (51) International Patent Classification: A61K 39/395 (2006.01) C12N 15/13 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01) C07K 16/46 (2006.01) (21) International Application Number: PCT/US2017/021616 (22) International Filing Date: 9 March 2017 (09.03.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/306,125 10 March 2016 (10.03.2016) US (71) Applicant: MEDIMMUNE, LLC [US/US]; One MedIm- mune Way, Gaithersburg, MD 20878 (US). (72) Inventors: VOUSDEN, Katherine, Ann; c/o MedImmune Limited, Milstein Building, Granta Park, Cambridge CB21 6GH (GB). DOUTHWAITE, Julie, Ann; c/o MedImmune Limited, Milstein Building, Granta Park, Cambridge CB21 6GH (GB). DAMSCHRODER, Melissa, Marie; c/o MedImmune LLC, One MedImmune Way, Gaithersburg, MD 20878 (US). SANJUAN, Miguel, Angel; c/o MedIm- mune LLC, One MedImmune Way, Gaithersburg, MD 20878 (US). (74) Agents: OYLOE, Jacob et al.; c/o MedImmune, LLC, One MedImmune Way, Gaithersburg, MD 20878 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) = (54) Title: ILT7 BINDING MOLECULES AND METHODS OF USING THE SAME Alignment VH : #2 -VH QVQLQQSGAELVKPGASVEMSCKAFGYTFO WME(QNHGKSLEWItarH 60 10D10 - via EVQLVESGGGVVQPGRELRLSCAASGFTFS . ri - F , IEWVRQAPGQGLEWIi ' , F - HIZYNDLITY 60 7C 7 -VH EVQLVESGGGVVQPGRSLRLSCAASGET QAPGQGLEW 60 #28 -VH NEKFKGKAKLTVEKSSSTVYLELSRLTSDDSAVYYCARGOOGU=MIGQGTSVTVSS 117 10D10 -VH NEKFKGRVIIITTDTSTSTVYMELSSLRSEDTAVYYCTRGE WGQGTLVTVSS 117 7C7-VH NEKFKGRVTMTTDTSTSTVYMELSSLRSEDTAVYYCTR GQGTLVTVSS 117 Figure lA (57) : The present invention is directed to ILT7 binding molecules, e.g., anti-ILT7 antibodies, and methods for treating or preventing conditions and diseases associated with ILT7-expressing cells such as autoimmune diseases. 111111111111110111011111111111010111110111011111111111110111111110111111111110111111 W O 20 17 / 15 6 298 Al