Patent SG-11201808830Y-A (SG)
Title: Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
Inventor: SKERLJ RENATO
IPC: C07D487/04
Filed: 2017-04-06
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11M11111011101 1111111111010111110111010111111111101100110111111111110111111 International Bureau ... .... ..Yjd .......,./ (10) International Publication Number (43) International Publication Date WO 2017/176960 Al 12 October 2017(12.10.2017) WIPO I PCT (51) International Patent Classification: (74) Agents: DAVIS, Chad, E. et al.; Goodwin Procter LLP, C07D 487/04 (2006.01) A61P 25/24 (2006.01) 100 Northern Avenue, Boston, MA 02210 (US). A61K 31/519 (2006.01) A61P 25/28 (2006.01) A61P 25/16 (2006.01) A61P 25/08 (2006.01) (81) Designated States (unless otherwise indicated, for every A61P 27/06 (2006.01) A61P 25/18 (2006.01) kind of national protection available): AE, AG, AL, AM, A61P 3/10 (2006.01) A61P 25/22 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61P 13/12 (2006.01) A61P 43/00 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, PCT/US2017/026280 KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (22) International Filing Date: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 6 April 2017 (06.04.2017) RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (25) Filing Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 62/318,929 6 April 2016 (06.04.2016) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: LYSOSOMAL THERAPEUTICS INC. TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, [US/US]; 19 Blackstone Street, Cambridge, MA 02139 TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (US). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventors: SKERLJ, Renato, T.; 12 Crocker Circle, West SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Newton, MA 02465 (US). BOURQUE, Elyse Marie GW, KM, ML, MR, NE, SN, TD, TG). Josee; 162 Ch Bouffard, L'etang-du-nord, Quebec, G4T 3G6 LANSBURY, Peter, T.; 24 Elm Street, Brook- Published: (CA). line, MA 02445 GOOD, Andrew, C.; 52 High Hill — international 21(3)) (US). with search report (Art. Road, Wallingford, CT 06492 (US). 1-1 © C:r IN 1-1 (54) Title: PYRAZOLO[1,5-A]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS 1-1 C (57) : The invention provides substituted pyrazolo[1,5-a]pyrimidinyl carboxamide and related organic compounds, com- e , ' positions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical dis - 0 orders, e.g., Gaucher disease, Parkinson's disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary ,1 . substituted pyrazolo[1,5-a]pyrimidinyl carboxamide compounds described herein include 2-heterocycly1-4-alkyl-pyrazolo[1,5- a]pyrirnidine-3-carboxarnide compounds and variants thereof.