baber/WOPTO huggingface dataset:
Patent EP-3902911-A2 (EP)
Inventor: BOWEN TYSON D
IPC: C12N15/113
Filed: 2019-12-20
Abstract: Compositions and methods for binding to a target sequence of interest are provided. Compositions include fusion proteins between DNA binding proteins or protein domains and nucleic acid modifying proteins or protein domains. The compositions find use in cleaving or modifying a target sequence of interest, visualization of a target sequence of interest, and modifying the expression of a sequence of interest. Compositions comprise RNA-guided nuclease polypeptides, CRISPR RNAs, trans-activating CRISPR RNAs, guide RNAs, deaminases, and nucleic acid molecules encoding the same. Vectors and host cells comprising the nucleic acid molecules are also provided. Further provided are CRISPR systems for binding a target sequence of interest, wherein the CRISPR system comprises an RNA-guided nuclease polypeptide and one or more guide RNAs. Also provided are deaminases which may be fused to a DNA-binding polypeptide and may be useful for gene editing.
Patent EP-3747899-A2 (EP)
Title: High avidity binding molecules recognizing mage-a1
Inventor: BLANKENSTEIN THOMAS
IPC: A61P35/00
Filed: 2014-01-29
Abstract: The present invention pertains to novel high avidity antigen recognizing constructs, such as antibodies or T cell receptors, which specifically bind to the melanoma associated antigen (MAGE) A1. The constructs of the invention are particularly useful for the diagnosis, prevention or therapy of tumorous diseases which are characterized by the specific expression of the MAGE-A1 antigen. Furthermore provided are nucleic acids, vectors and host cells - such as CD4 or CD8 positive T cells - which encode, comprise or present the antigen recognizing constructs of the invention. The invention thus provides new means for immune therapy, specifically adoptive T cell therapy, for treating cancer.
Patent EP-3818991-A2 (EP)
Inventor: BYRNE BARRY JOHN
IPC: A61K48/00
Filed: 2013-06-19
Abstract: The present invention provides compositions and methods of use pertaining to rAAV- mediated delivery of therapeutically effective molecules for treatment of diseases such as Pompe disease. These compositions in combination with various routes and methods of administration result in targeted expression of therapeutic molecules in specific organs, tissues and cells.
Patent EP-3733857-A2 (EP)
Inventor: SATO SEIZO
IPC: C12N1/28
Filed: 2014-12-04
Abstract: A microbial oil comprising dihomo-γ-linolenic acid as a constituent fatty acid of an oil, the microbial oil has a content, in terms of a weight ratio of arachidonic acid relative to dihomo-γ-linolenic acid (arachidonic acid/dihomo-γ-linolenic acid) of less than 1/13. Preferably, the microbial oil has a triglyceride content of greater than or equal to 70% by weight, and a saturated fatty acid content of less than or equal to 40% by weight. Moreover, a lower alcohol ester of dihomo-γ-linolenic acid or a free fatty acid of dihomo-γ-linolenic acid obtained from the microbial oil is provided.
Patent EP-3815555-A2 (EP)
Title: Control device of aerosol inhaler
Inventor: MARUBASHI KEIJI
IPC: A61M11/04
Filed: 2020-10-28
Abstract: A control device of an aerosol inhaler includes a load 21 heating an aerosol generation source, in which a temperature and an electric resistance value of the load are correlated. The control device includes: a voltage sensor 17 configured to output a voltage value applied to the load; a constant current circuit configured to output a constant current to the load; and a control circuit 50 configured to acquire the electric resistance value of the load or the temperature of the load based on output of the voltage sensor and the constant current.
Patent EP-3819921-A2 (EP)
Title: Zinc oxide varistor ceramics
Inventor: CERGOLJ MIRJAM
IPC: H01C7/105
Filed: 2020-12-10
Abstract: Provided according to embodiments of the invention are varistor ceramic formulations that include zinc oxide (ZnO). In particular, varistor ceramic formulations of the invention may include dopants including an alkali metal compound, an alkaline earth compound, an oxide of boron, an oxide of aluminum, or a combination thereof. Varistor ceramic formulations may also include other metal oxides. Also provided according to embodiments of the invention are varistor ceramic materials formed by sintering a varistor ceramic formulation according to an embodiment of the invention. Further provided are varistors formed from such ceramic materials and methods of making such materials.
Patent EP-4069146-A2 (EP)
Inventor: HOU DONGMING
IPC: A61F2/24
Filed: 2020-12-01
Abstract: An implant system and method of delivery includes a catheter system including a sling catheter having a plurality of distal openings and a delivery catheter, disposed within the sling catheter and having a distal port. Suture coupled anchors may be sequentially delivered by the delivery catheter to a cardiac treatment site by aligning the port of the delivery catheter with different openings of the sling catheter and pushing the anchor through the port and the sling catheter to embed the anchor into cardiac tissue such as tissue of a papillary muscle. Each anchor may have a linear configuration for translation within the delivery catheter and a biased configuration that inhibits its reentry into the sling catheter once deployed. Once all anchors are deployed, the suture may be tightened, the anchored portion of the sling catheter may be detached, and the catheter system withdrawn.
Patent EP-4048723-A2 (EP)
Inventor: ZHU YAN
IPC: C08J5/24
Filed: 2020-10-20
Abstract: Pre-impregnated composite material (prepreg) that can be cured/molded to form aerospace composite parts. The prepreg includes carbon reinforcing fibers and an uncured resin matrix. The resin matrix includes an epoxy resin component, polyethersulfone as a toughening agent, a thermoplastic particle component, a nanoparticle component and a curing agent
Patent EP-4081309-A2 (EP)
Inventor: BURNS KATHLEEN H
IPC: A61K31/675
Filed: 2020-12-26
Abstract: Methods for treating a neoplasia are provided. Further provided.are novel targets for cancer chemotherapy including ORF2p protein and methods for increasing expression of ORF2p in neoplasias. Monoclonal antibodies are also provided to various epitopes of ORF2p and their use in research and diagnostics.
Patent EP-3929866-A2 (EP)
Inventor: ZOU ZHIKANG
IPC: G06T7/11
Filed: 2021-11-04
Abstract: The disclosure provides an inpainting method for a human image, an inpainting apparatus for a human image and an electronic device. An image to be processed is received (S101). The image to be processed contains a human image to be processed. A three-dimensional human body model corresponding to the human image to be processed, camera parameters, and human body posture information are generated (S102) based on the image to be processed. A segmentation image corresponding to the human image to be processed is generated (S103) based on the image to be processed. A processed human image corresponding to the human image to be processed is generated (S104) based on the three-dimensional human body model, the camera parameters, the human body posture information, and the segmentation image.
Patent EP-4121858-A2 (EP)
Inventor: MOLA JORDI
IPC: G06F11/34
Filed: 2021-05-04
Abstract: Reducing overheads of recording a replayable execution trace of a program's execution at a computer processor by omitting logging of accesses to memory addresses whose values can be reconstructed or predicted. A computer system determines that memory values corresponding to a range of memory addresses within a memory space for a process can be obtained separately from the process' execution, and configures a data structure for instructing a processor to omit logging of memory accesses when the processor accesses an address within this range while executing the process. Correspondingly, upon detecting a memory access while executing the process, the processor determines if it has been instructed to omit logging of the access by checking the data structure. When the data structure instructs the processor to omit logging of the access, the processor omits logging the memory access while it uses a cache to process the memory access.
Patent EP-4121462-A2 (EP)
Title: T-cell bispecific binding proteins
Inventor: PALCHAUDHURI RAHUL
IPC: A61K39/395
Filed: 2021-03-16
Abstract: Provided herein are compositions and methods useful for the T-cell mediated depletion of hematopoietic stelm cells (HSCs) expressing an HSC antigen, e.g., CD117+ cells, and for the treatment of various hematopoietic diseases, metabolic disorders, cancers,  e.g.,  acute myeloid leukemia (AML) and autoimmune diseases, among others. Described herein are bispecific binding polypeptides, and bispecific antigen-binding portions thereof, comprising a first binding moiety to a T cell antigen, such as CD3, and a second binding moiety to an HSC antigen, such as CD117.
Patent EP-4128045-A2 (EP)
Inventor: FINN DAVID
IPC: H01Q1/00
Filed: 2021-04-01
Abstract: A transaction card (smartcard) having a front "continuous" (with no slit) metal layer (ML, FML, 930, 1130) with an opening (912, 1112) for a dual-interface transponder chip module (TCM, 910, 1110) having a module antenna (MA, 911, 1111) on its bond side (not shown). A magnetic shielding layer (MSL, 942, 1142) comprising ferrite material disposed below the front face continuous metal layer. An amplifying element, booster antenna circuit (BAC, 944, 1144) disposed under the magnetic shielding layer. A rear discontinuous metal layer (ML, DML, 950, 1150) with a slit (S, 920, 1120) and a metal ledge (916, 1116) surrounding a module opening (MO, 914, 1114) to function as a coupling frame (CF). A rear plastic layer (960, 1160) formed of non-RF impeding material may capture a magnetic stripe and security elements (signature panel and hologram). A portion of the front face continuous metal layer may protmde downward into the magnetic shielding layer and booster antenna circuit layer. The rear discontinuous metal layer may have an additional slit to regulate the activation distance.
Patent EP-4264045-A2 (EP)
Title: Power generator with multiple turbine units
Inventor: BELTRAN JOSE LEON
IPC: F03G3/02
Filed: 2021-12-16
Abstract: A power generator having an impeller configured to facilitate the translation of balls through a ball-actuated turbine and facilitate the transfer of water to drive a water-actuated turbine. The impeller is located within a fluid compartment and creates a turbulent water flow, which generates an inverted vortex. The impeller includes a central bore having an outlet communicating with the fluid compartment and an inlet communicating with a feed space. An array of balls is supplied to the impeller bore via the feed space and traverses the bore in response to the vortex. The balls ascend through the fluid compartment and an upper water tank. At a higher elevation, the ascending balls are routed downstream via gravity to the ball-actuated turbine, while water is routed downstream via gravity to the water-actuated turbine. After performing their respective turbine-driving actions, the water and balls recirculate to the feed space to repeat the cycle.
Patent EP-4270568-A2 (EP)
Title: Unit cell, and method and device for manufacturing same
Inventor: PARK DONG HYEUK
IPC: H01M10/04
Filed: 2021-12-23
Abstract: The present invention relates to an apparatus for manufacturing a unit cell, which cuts a lower separator and an upper separator between electrodes adjacent to each other in a process of manufacturing the unit cell provided in a state, in which the lower separator and the upper separator continuously move in a longitudinal direction, and the electrodes are stacked between the lower separator and the upper separator and on the upper separator, respectively, the apparatus comprising: a lower block disposed under the lower separator; and an upper block which is vertically aligned with the lower block above the upper separator and in which a lower end of a cutter is installed to be accessible to the inside and outside, wherein the upper block descends to press the separators to a surface of the lower block, wherein at least one or more of the upper block and the lower block is heated to a predetermined temperature so that pressed points of the separators are thermally fused, and the cutter protrudes from the upper block to perform cutting at points at which the separators are pressed.
Patent EP-4138146-A2 (EP)
Title: Stapelförmige hochsperrende iii-v-halbleiterleistungsdiode
Inventor: FUHRMANN DANIEL
IPC: H01L29/205
Filed: 2020-04-06
Abstract: Gemäß dem ersten Gegenstand der Erfindung wird eine stapelförmige hochsperrende III-V-Halbleiterleistungsdiode bereitgestellt, aufweisend eine zumindest gebietsweise ausgebildete erste metallische Anschlusskontaktschicht und einen hochdotierten Halbleiterkontaktbereich eines ersten Leitfähigkeitstyps mit einer ersten Gitterkonstante. Des Weiteren ist eine Driftschicht eines zweiten Leitfähigkeitstyps vorgesehen. Außerdem ist eine hochdotierte metamorphe Pufferschichtfolge von dem zweiten Leitfähigkeitstyp ausgebildet. Die metamorphe Pufferschichtfolge weist eine Oberseite mit der ersten Gitterkonstante und eine Unterseite mit einer zweiten Gitterkonstante auf, wobei die erste Gitterkonstante größer als die zweite Gitterkonstante ist. Die Oberseite der metamorphen Pufferschichtfolge ist in Richtung der Driftschicht angeordnet. Unterhalb der Unterseite der metamorphen Pufferschichtfolge ist eine zweite metallische Anschlusskontaktschicht angeordnet. Es sei angemerkt, dass die vorgenannten Bereiche und Schichten in der genannten Reihenfolge angeordnet sind. Die zweite metallische Anschlusskontaktschicht ist stoffschlüssig mit einer Halbleiterkontaktschicht verbunden.
Patent EP-4221242-A2 (EP)
Inventor: SINGH MONA
IPC: H04N21/8549
Filed: 2018-01-16
Abstract: Information may be provided for review by an augmented reality (AR) user. A system may store a plurality of scenes viewed by the AR user, and for each scene information identifying (i) any pairs of reallife objects and AR augmentations presented in the scene and (ii) any pairs in the scene with which the user interacted. The system may also select from the stored plurality of scenes a first subset of scenes such that each pair with which the user interacted is presented in at least one scene in the first subset of scenes. Responsive to an instruction from the user to review historical AR information, the system may present to the user the selected first subset of scenes. The first subset may be selected such that each pair with which the user interacted is presented in at least one scene in which the user interacted with that pair.
Patent EP-4284817-A2 (EP)
Inventor: WANG ZHIQING
IPC: C07K14/395
Filed: 2022-01-26
Abstract: The present disclosure concerns recombinant yeast host cells having a first genetic modification to express a heterologous polypeptide or to over-express a native polypeptide. The recombinant yeast host cells also have a second genetic modification to at least partially mitigate the reduction in growth rate resulting from the expression of the heterologous polypeptide or the over-expression of the native polypeptide. The second genetic modification can be, for example, to favor the secretion of the heterologous or native polypeptide.
Patent EP-4290535-A2 (EP)
Inventor: CARROLO NUNO
IPC: H01B13/012
Filed: 2023-02-23
Abstract: Provided is a routing element for use in a cable harness manufacturing system comprising an assembly board having an attachment surface configured for receiving tooling components to support and locate a cable harness during manufacture. The routing element comprises: an upper fixture support having a least one aperture for receiving a tooling component to support said cable harness during manufacture; and a lower suction holder comprising at least two suction cups for attaching the routing element to the assembly board. The lower suction holder and the upper fixture support are located axially about a central vertical axis of the routing element, and the lower suction holder extends outwardly relative to the upper fixture support, such that the area covered by the lower suction holder is greater than that of the upper fixture support. Also provided is a cable harness manufacturing system, and a kit comprising routing elements, spacer elements and support plates for use with an assembly board during cable harness manufacture.
Patent EP-4234989-A2 (EP)
Inventor: NASMAN BENJAMIN JAMES
IPC: F16J15/34
Filed: 2020-06-05
Abstract: An assembly (10) is provided for a gas turbine engine. This gas turbine engine assembly includes a pin (32), a seal support assembly (34) and a seal element (30). The pin (32) is configured with a pin fluid passage (80). The seal support assembly (34) is mated with and slidable along the pin (32). The seal element (30) is mounted to the seal support assembly (34). The seal element (30) is configured with a seal element fluid passage (56) that is fluidly coupled with the pin fluid passage (80) through the seal support assembly (34).
Patent EP-4235722-A2 (EP)
Inventor: GROSSBERG AMIR
IPC: H01H9/54
Filed: 2020-02-28
Abstract: A relay array may connect an electrical device (e.g., an inverter, power converter, etc.) to a utility grid. Based on a detection of a power interruption or fault, the relay array may disconnect the electrical device from the grid to ensure safety or reduce damage to the electrical device or grid. The relay array may include one or more latching relays. A safety catch may prevent the latching relay(s) from changing states. The electrical device may be configured to facilitate removal of the safety catch once the ability to change states is desired. The latching relay(s) may also be supplied with a power pulse for changing a state of the latching relay(s). The power pulse may be provided by a power bank that may be maintained with power in case of a power interruption or fault.
Patent EP-4253330-A2 (EP)
Inventor: BARKER JEREMY
IPC: C01G53/00
Filed: 2019-04-08
Abstract: The invention relates to O3/P2 mixed-phase sodium-containing doped layered oxide materials which comprise a mixture of a first phase with an O3-type structure and a second phase with a P2-type structure; wherein the O3:P2 mixed-phase sodium-containing doped layered oxide material has the general formula: Na<sub>a</sub>A<sub>b</sub>M<sup>1</sup><sub>c</sub> M<sup>2</sup><sub>d</sub> M<sup>3</sup><sub>e</sub>M<sup>4</sup><sub>f</sub> M<sup>5</sup><sub>g</sub> O<sub>2±δ</sub>. The invention also provides a process for making such O3/P2 mixed-phase sodium-containing doped layered oxide materials, and use applications therefor.
Patent EP-4234140-A2 (EP)
Inventor: HAIMER FRANZ
IPC: B23C5/26
Filed: 2013-01-23
Abstract: Die Erfindung betrifft ein Einschraubwerkzeug (1) und eine Werkzeugaufnahme (2) für ein derartiges Einschraubwerkzeug. Das Einschraubwerkzeug (1) enthält einen Werkzeugkopf (3) und einen Werkzeugschaft (4) mit einem Außengewinde (5) und einem zwischen dem Werkzeugkopf (3) und dem Außengewinde (5) angeordneten Abstützbereich. Der Abstützbereich wird erfindungsgemäß durch zwei konische Anlageflächen (6, 8) mit unterschiedlichen Kegelwinkeln gebildet.
Patent EP-4273666-A2 (EP)
Inventor: DE CESARE JOSHUA P
IPC: G06F1/3287
Filed: 2011-04-07
Abstract: In an embodiment, a power management unit (PMU) may automatically transition (in hardware) the performance states of one or more performance domains in a system. The target performance states to which the performance domains are to transition may be programmable in the PMU by software, and software may signal the PMU that a processor in the system is to enter the sleep state. The PMU may control the transition of the performance domains to the target performance states, and may cause the processor to enter the sleep state. In an embodiment, the PMU may be programmable with a second set of target performance states to which the performance domains are to transition when the processor exits the sleep state. The PMU may control the transition of the performance domains to the second targeted performance states and cause the processor to exit the sleep state.
Patent EP-4277417-A2 (EP)
Title: Base station, terminal, transmission method, and reception method
Inventor: NUNOME TOMOYA
IPC: H04W72/542
Filed: 2020-08-28
Abstract: This base station is provided with: a control circuit which determines a disposition method for a downlink control channel signal in at least one among a first period before a timing based on a carrier sense and a second period after the timing based on the carrier sense on the basis of information about at least one among the number of times a downlink control channel signal is blind-decoded and the number of resources for channel estimation; and a transmission circuit which transmits the downlink control channel signal on the basis of the determined disposition method.
Patent EP-4318410-A2 (EP)
Title: Distributed application architectures using blockchain and distributed file systems
Inventor: SEMENOV DMYTRO
IPC: G06V10/82
Filed: 2019-10-03
Abstract: Aspects relate to a computer-implemented method, a distributed application architecture system, a computer program and one or more computer storage media for reconstructing or reassembling a data object stored in a distributed application architecture. The computer-implemented method comprises receiving a request to access a data object that includes an object identifier for the data object. The method further comprises retrieving, using an object identifier of the data object, an object data block for the data object from an object data blockchain where the object data block is stored. The method further comprises reassembling the data object using the object data block and obtaining critical content from the object data block. For each noncritical data element in the object block, the method further comprises using an address stored for the data object to obtain a data block file for the data element from a distributed file system. The method further comprises reassembling the data object using the critical content and the data block files for the noncritical data elements and returning the reassembled data object to the requesting entity.
Patent EP-0010029-A2 (EP)
Inventor: BISAGNI EMILE
IPC: C07D209/86
Filed: 1979-09-19
Abstract: "Nouveaux dérivés des pyrido (4, 3-b) carbazoles (ellipticines), substitués en position 1 par une chaîne polyaminée, leur obtention et leur application à titre de médicaments" Composés de formule <IMAGE> dans laquelle R1 est un groupement Y-(CH2)n-NR4R5, où Y représente une liaison simple ou le groupe: <IMAGE> R4 et R5, identiques ou différents, sont l'hydrogène ou un radical alkyle, de préférence inférieur, ou encore forment ensemble un cycle pouvant comporter des hétéro-atomes, en particulier des atomes d'azote, et n est un nombre allant de 1 à
Patent EP-0016661-A2 (EP)
Inventor: FITZGERALD CORNELIUS GILBERT
IPC: C10C3/00
Filed: 1980-03-26
Abstract: An optically anisotropic deformable pitch precursor, which upon appropriate heating forms a material suitable for the manufacture of carbon fibres, is prepared from a carbonaceous isotropic pitch. The latter is treated with an organic solvent system having a solubility parameter between 1.0 and 9.5, preferably a toluene/heptane mixture. Normally the solvent system is employed in an amount of 5 to 150ml per gram of pitch. The solvent system contains a dealkylation catalyst, preferably SnCl 4 , FeCl 3 , AlCl 3  or BF 3  an amount of 5.0 wt.% based on the pitch. A catalyst- solubilizing agent can also be added. Reaction between catalyst and pitch is effected at a temperature normally between 30°C and 250°C and for a time, suitable from 1 to 5 hours, sufficient to increase the solvent-insoluble fraction of the pitch. Thereafter the solvent-insoluble fraction is separated as the precursor product.