Patent SG-11201908131R-A (SG)
Title: Benzazepine compounds, conjugates, and uses thereof
Inventor: COBURN CRAIG ALAN
IPC: A61K31/55
Filed: 2018-03-14
Abstract: E 8000 o. z I- 100 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIP0 I PCT onion 0111010M OE Ell IIIII 1011 IIIIIIIII IUD IIII Ill IIII (10) International Publication Number WO 2018/170179 Al (51) International Patent Classification: A61K 31/55 (2006.01) C07D 403/12 (2006.01) (21) International Application Number: PCT/US2018/022510 (22) International Filing Date: 14 March 2018 (14.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: [US/US]; 500 Fairview Avenue North, Suite 600, Seattle, Washington 98109 (US). (72) Inventors: COBURN, Craig Alan; 500 Fairview Avenue North, Suite 600, Seattle, Washington 98109 (US). BAUM, Peter Robert; 500 Fairview Avenue North, Suite 600, Seat- tle, Washington 98109 (US). SMITH, Sean Wesley; 500 Fairview Avenue North, Suite 600, Seattle, Washington 98109 (US). (74) Agent: MINITTI, Julia L. et al.; Wilson Sonsini Goodrich & Rosati, 650 Page Mill Road, Palo Alto, California 94304-1050 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). 62/471,886 15 March 2017 (15.03.2017) US 62/573,630 17 October 2017 (17.10.2017) US 62/622,780 26 January 2018 (26.01.2018) US (71) Applicant: SILVERBACK THERAPEUTICS, INC. W O 20 18/ 17 0 17 9 Al (54) Title: BENZAZEPINE COMPOUNDS, CONJUGATES, AND USES THEREOF PBMC + SKBR3: 24HRS FIGURE 1 (57) : Benzazepine compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as can- cer, are disclosed herein. The disclosed benzazepine compounds are useful, among other things, in the treating of cancer and modulating TLR8. Additionally, benzazepine compounds incorporated into a conjugate with an antibody construct are described herein. [Continued on next page] -0- HER2 x CD40 - HER2 - G1VVT HER2 x CD40 - conjugate AA - HER2 - G1VVT - conjugate BB -0- HER2 - G1WT - conjugate CC -a- HER2 - G1WT - conjugate DD ▪ HER2 x CD40 - conjugate EE - o- HER2 x CD40 - conjugate FF - HER2 - G1VVT - conjugate GG -0- HER2 x CD40 - conjugate BB -x- SKBR3+PBMC ALONE WO 2018/170179 Al IMEDIM01101 DIONE101301011g11111111111101111111111111111111 Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))