Patent SG-11201902879S-A (SG)
Title: Immunoglobulins and uses thereof
Inventor: MACIELAG MARK
IPC: A61K39/395
Filed: 2017-10-26
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111411 0 11101 HOE 3E1 0 011111111111 0111001 HE EMI IIE OEN International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2018/081375 Al 03 May 2018 (03.05.2018) WIP0 I PCT (51) International Patent Classification: tha 92121 (US). D'AQUINO, Katharine, E.; 1400 McK- A61K 39/00 (2006.01) C07K 16/18 (2006.01) can Road, Spring House, Pennsylvania 19477 (US). ED- A61K 39/395 (2006.01) C12P 21/08 (2006.01) WARDS, Wilson; 3210 Merryfield Row, San Diego, Cal- C07K 16/00 (2006.01) ifornia 92121 (US). SWANSON, Ronald V.; 3210 Mer- (21) International Application Number: PCT/US2017/058462 ryfield Row, San Diego, California 92121 (US). MAN, Wenying; 1400 McKean Road, Spring House, Pennsylva- nia 19477 (US). CHI, Ellen; 3210 Merryfield Row, San (22) International Filing Date: Diego, California 92121 (US). 26 October 2017 (26.10.2017) (74) Agent: BARANIAK, Andrew P. et al.; Panitch Schwarze (25) Filing Language: English Belisario & Nadel LLP, Two Commerce Square, 2001 Mar- ket Street, Suite 2800, Philadelphia, Pennsylvania 19103 (26) Publication Language: English (US). (30) Priority Data: (81) Designated States (unless otherwise indicated, for every 62/413,586 27 October 2016 (27.10.2016) US kind of national protection available): AE, AG, AL, AM, 62/413,613 27 October 2016 (27.10.2016) US AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (71) Applicant: JANSSEN PHARMACEUTICA NV [BE/BE]; Turnhoutseweg 30, B-2340 Beerse (BE). CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (72) Inventor; and HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (71) Applicant (for US only): MACIELAG, Mark [US/US]; 1400 McKean Road, Spring House, Pennsylvania 19477 (US). MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, = Inventors: MACIELAG, Mark; 1400 McKean Road, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = (72) Spring House, Pennsylvania 19477 (US). PATCH, Ray- (84) Designated States (unless otherwise indicated, for every — mond, J.; 1400 McKean Road, Spring House, Pennsyl- vania 19477 (US). ZHANG, Rui; 1400 McKean Road, Spring House, Pennsylvania 19477 (US). CASE, Mar- tin, A.; 3210 Merryfield Row, San Diego, California kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 92121 (US). WALL, Mark; 1400 McKean Road, Spring House, Pennsylvania 19477 (US). ZHANG, Yue-Mei; 1400 McKean Road, Spring House, Pennsylvania 19477 (US). RANGWALA, Shamina, M.; 1400 McKean Road, Spring House, Pennsylvania 19477 (US). LEONARD, James, N.; 1400 McKean Road, Spring House, Pennsyl- TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — = vania 19477 (US). CAMACHO, Raul, C.; 1400 McKean _ as to applicant's entitlement to apply for and be granted a — — Road, Spring House, Pennsylvania 19477 (US). HUNTER, Michael, J.; 3210 Merryfield Row, San Diego, Califor- patent (Rule 4.1700) = = = = (54) Title: IMMUNOGLOBULINS AND USES THEREOF = Fig. 1 x = 11 ir) HN IN en SH 11 N H I GO pepticie—N v-regio(i H Cys {in CDR) sr-r4on — mAb constant region © --.... 1-1 (57) : The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to C:::: ) increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods el for use thereof. C [Continued on next page] WO 2018/081375 Al MIDEDIMOHNIMMIMIERIMMEMIIMMOMEHOIMIE Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))