Patent SG-11201804132U-A (SG)
Title: Eif4-a-inhibiting compounds and methods related thereto
Inventor: ERNST JUSTIN
IPC: A61K31/5377
Filed: 2016-11-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau ... ....,*/ /d (43) International Publication Date .... .....r ,„„0 1 June 2017 (01.06.2017) WIPO I PCT ID Hit (10) WO International 2017/091585 111111111111111111111111111111110111111HIIIIIIIIIIMIIIIIIIIIIIIIII Publication Al Number (51) International Patent Classification: NILEWSKI, Christian; 5940 La Jolla Mesa Drive, La A61K 31/5377 (2006.01) A61K 31/4706 (2006.01) Jolla, CA 92037 (US). MICHELS, Theodore; 4353 A61K 31/4709 (2006.01) Felton St. #3, San Diego, CA 92104 (US). (21) International Application Number: (74) Agent: PINO, Mark, J.; Mintz Levin Cohn Ferris Glovsky PCT/US2016/063353 And Popeo, PC, 701 Pennsylvania Avenue, Nw, Suite 900, Washington, DC 20004 (US). (22) International Filing Date: 22 November 2016 (22.11.2016) (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (26) Publication Language: English BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (30) Priority Data: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 62/259,828 25 November 2015 (25.11.2015) US KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 62/334,149 10 May 2016 (10.05.2016) US MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (71) Applicant: EFFECTOR THERAPEUTICS, INC. OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, [US/US]; 11180 Roselle Street, San Diego, CA 92121 SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (US). TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventors: ERNST, Justin, T.; 4288 Kerwood Court, San Diego, CA 92130 (US). REICH, Siegfried, H.; 5940 La (84) Designated States (unless otherwise indicated, for every Jolla Mesa Drive, La Jolla, CA 92037 (US). SPRENGEL- kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, ER, Paul, A.; 8706 Gracilior Court, Escondido, CA 92026 TRAN, Chinh; 2736 Bellezza Drive, San Diego, CA TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (US). 92108 PACKARD, Garrick, Kenneth; 4485 Vision TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (US). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Dr Apt. 6, San Diego, CA 92121 (US). XIANG, Alan, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Xin; 211 Midvale Lane, Irvine, CA 92620 (US). [Continued on next page] Title: EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO (54) (57) : The present invention provides synthesis, pharmaceutically acceptable foiinulations and uses of in Foiinula I, compounds accordance with or a stereoi- R4 b 4a somer, tautomer or pharmaceutically acceptable salt thereof. For Foiinula (I) compounds X, Y, R I , R, R 2 3 a, e 3 b R ib , R 4a , R a and R 5 are as defined in the specification. e The inventive Foiinula (I) compounds are inhibitors of N b . R5 % elF4A and fmd utility in any number of therapeutic ap- R3a including but not limited to treatment of in- plications, flammation and various cancers. ••• e e / 1 x .... a 1-1 .4t in GC in 1 - 1 01 0 IN 1 - 1 C ei (T) 0 WO 2017/091585 Al MIONIM011EMIMOIDEDMEIM111111111111111111111111111111 SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, before the expiration of the time limit for amending the GW, KM, ML, MR, NE, SN, TD, TG). Published: claims and to be republished amendments (Rule 48.2(h)) in the event of receipt of — with international search report (Art. 21(3))