baber/WOPTO huggingface dataset:
Patent EC-SP13012416-A (EC)
Title: Derivados heterocíclicos fusionados como moduladores s1p
Inventor: IWEMA BAKKER WOUTER I
IPC: C07D513/04
Filed: 2013-02-04
Abstract: La presente invención se relaciona con un derivado heterocíclico fusionado de la fórmula (I) (I)en dondeR1 se selecciona de ciano, alquenilo (C 2-4), alquinilo (C 2-4), alquilo (C 1-4), cada uno opcionalmente sustituido con CN o uno o más átomos de flúor, cicloalquilo (C 3-6), cicloalquenilo (C 4-6) o un grupo bicíclico (C 8-10), cada uno opcionalmente sustituido con halógeno o alquilo (C 1-4) opcionalmente sustituido con uno o más átomos de flúor,fenilo, bifenilo, naftilo, cada uno opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente de halógeno, ciano, alquilo (C 1-4) opcionalmente sustituido con uno o más átomos de flúor, alcoxi (C 1-4) opcionalmente sustituido con uno o más átomos de flúor, amino, dimetilamino, y cicloalquilo (C 3-6) opcionalmente sustituido con fenilo que se puede sustituir con alquilo (C 1-4) o halógeno, yfenilo sustituido con fenoxi, bencilo, benciloxi, feniletilo o heterociclo monocíclico, cada uno opcionalmente sustituido con alquilo (C 1-4), Z es un grupo de enlace -W-(alquileno Cn)-T- en donde W se adhiere a R1 y se selecciona de un enlace, -O-, -CO-, -S-, -SO-, -SO2-, -NH-, -CH=CH-, -C(CF3)=CH-, -C?C-, -CH2-O-, -O-CO-, -CO-O-, -CO-NH-, -NH-CO- y trans-ciclopropileno; n es un entero de 0 a 10; y T se adhiere al grupo funcional fenileno/ piridilo y se selecciona de un enlace, -O-, -S-, -SO-, -SO2-, -NH-, -CO-, -C=C-, -C?C-, y trans-ciclopropileno;R2 es H o uno o más sustituyentes seleccionados independientemente de ciano, halógeno, alquilo (C 1-4) opcionalmente sustituido con uno o más átomos de halógeno, o alcoxi (C 1-4) opcionalmente sustituido con uno o más átomos de halógeno;la estructura del anillo A puede contener un átomo de nitrógeno;X se selecciona de C o N; si X es C, R3 se selecciona de H y alquilo (C 1-4), de otra forma R3 no está presente;Y se selecciona de NH, O y S;la estructura Q es una amina cíclica de 5, 6 o 7 miembros; R4 es alquileno (C 1-4)-R5 en donde uno o más átomos de carbono en el grupo alquileno se pueden sustituir independientemente con uno o más átomos de halógeno o con (CH2)2 para formar un grupo funcional ciclopropilo, o R4 es cicloalquileno (C 3-6)-R5, -CH2-cicloalquileno (C 3-6)-R5, cicloalquileno (C 3-6)-CH2-R5 o -CO-CH2-R5, en donde R5 es -OH, -PO3H2, -OPO3H2, -COOH, -COOalquilo (C 1-4) o tetrazol -5- ilo;o una sal farmacéuticamente aceptable, un solvato o hidrato del mismo o uno o más N- óxidos del mismo.Los compuestos de la invención tienen afinidad con los receptores S1P y se puedan utilizar en el tratamiento, alivio o prevención de enfermedades y afecciones en las que (cualquier) receptor (es) S1P está (están) involucrados o en las que está involucrada la modulación del sistema de señalización S1P endógeno a través de cualquier receptor S1P.
Patent EC-SP13012654-A (EC)
Title: Composiciones farmacéuticas
Inventor: LI PING
IPC: A61P35/00
Filed: 2013-06-03
Abstract: La presente invención se refiere a una composición farmacéutica para la administración oral de un compuesto terapéutico de la fórmula (I), la cual comprende gránulos que comprenden por lo menos compuesto terapéutico de la fórmula (I) (véase más adelante), en particular el 2-metil-2-[4-(3-metil-2-oxo-8- quinolin-3-il-2,3-dihidro-imidazo-[4,5-c]-quinolin-1-il)-fenil]-propionitrilo o la 8-(6-metoxi-piridin-3-il)-3-metil-1-(4-piperazin-1-il-3-trifluoro-metil-fenil)-1,3-dihidro-imidazo-[4,5-c]-quinolin-2-ona, o un tautómero de los mismos, o una sal farmacéuticamente aceptable, o un hidrato o un solvato de los mismos; por lo menos un tensoactivo no iónico que es la Vitamina E-TPGS, en una cantidad en el intervalo de aproximadamente el 15 a aproximadamente el 80 por ciento en peso de la composición; y por lo menos un agente mejorador de disolución seleccionado a partir de polietilenglicol, poli-óxido de etileno, y cualquier combinación de los anteriores. La presente invención también se refiere a procesos para la elaboración de estas composiciones farmacéuticas; a un kit que comprende esta composición farmacéutica y las instrucciones que disponen que la composición farmacéutica se pueda tomar desde inmediatamente hasta aproximadamente treinta minutos después del consumo de alimento; y a los usos y métodos de tratamiento relacionados.
Patent GB-189703221-A (GB)
Title: An Improved Tension Device for Knitting and other Textile Machines.
Inventor: MILLAR JOHN
Filed: 1897-02-06
Granted: 1897-12-11
Abstract: 3221. Millar, J. Feb. 6. Knitting - machines. - The thread c is passed through a cloth-covered guide-ring d<1> and through an eye e, and one or more times round a smooth screw a to the work. The tension can be regulated by varying the number of turns round the screw.
Patent GB-189706512-A (GB)
Title: Improvements in the Means of Ventilating the Roofs of Stables, Cowhouses, or Shippons, and other like Buildings.
Inventor: GREEN HARGREAVES
Filed: 1897-03-12
Granted: 1898-02-12
Abstract: 6512. Green, H. March 12. Ventilators f o r ventilating stables, cow-houses. fowlhouses, and like buildings so as to avoid draughts and regulate the ventilation. In the section of part of a building shown in Fig. 2, the fresh air is admitted through gratings J i n t o Tobin tubes K, w h i c h discharge the air over the heads of the animals in the stalls L. The outlet of the Tobin tubes may be regulated by a sliding board K<1>. The foul air is drawn off at the roof by a shaft E F provided with two flap valves H for regulating the outflow. The spaces between the rafters are packed with non-conducting materials to prevent the ingress of cold air.
Patent GB-189711107-A (GB)
Title: An Improvement in Bottles to Prevent Re-filling.
Inventor: TONKIN JAMES EBENEZER
Filed: 1897-05-04
Granted: 1897-08-21
Abstract: 11,107. Tonkin, J. E., Liardet, A. C. C., and Soutter, J. L. May 4. Stoppers; refilling, preventing.-Relates to means for preventing the refilling of bottles. A block of glass &c. A, which is cemented in the neck, is formed with two conical valve chambers C, D, which meet at an angle, as shown. In these chambers are placed two balls E, F, each adapted to close the lower (narrow) end of its respective chamber. The valves are protected by a perforated plate B. The valves permit liquid to be poured out, but prevent its introduction, as one or other of the valves will be seated except when the bottle is inverted. The block A may be made separate from the neck, or it may be made integral with a part of the neck, which is made separate and afterwards cemented in position.
Patent GB-189712392-A (GB)
Title: Glass Blowing Machine.
Inventor: GROTE LUDWIG
Filed: 1897-05-19
Granted: 1898-04-02
Abstract: 12,392. Grote, L. May 19. Blowing; moulding.-Relates to machines for blowing bottles and other hollow-ware. In the form shown in Fig. 1, two moulds B, B' are mounted on a disc a, the air-supply tubes k<1> being put in communication with the main pipe k only when the moulds are in the lower position as shown at B'. Glass is first poured into the inverted mould as shown at B ; the mould is then inverted, the bottom is closed by the disc h, and the bottle blown by lifting the mandrel c and admitting air to the canal formed by the mandrel in the molten glass. In a modification, of which Fig. 4 shows a part, moulds are carried at each end of a hollow shaft o communicating with the compressed-air reservoir. The glass is admitted as before into the inverted mould d, a plunger forcing the glass into the neck mould d<1>. . The mould having been turned over, the glass is allowed to extend by its own weight, and the bottom of the pendulous mass is chilled by the plate d<2>. The mould d is now opened, and a finishing-mould, not shown, closes round the glass, which is blown by raising the plunger m, through which the air is admitted.
Patent GB-189713768-A (GB)
Title: Improvements in the Manufacture of Chinese India-rubber Shoes.
Inventor: MATTHEW PATRICK MILLAR
Filed: 1897-06-04
Granted: 1898-04-09
Abstract: 13,768. Matthew, P. M. June 4. Uppers for Chinese india-rubber shoes. Sheetrubber is passed through rollers, one of which is engraved as shown in Fig. 2. A, A are rows of stitching, B, B are channels to form the beadings b, b at the toe, and C is a channel to form the thickened and beaded edge C, Fig. 3.
Patent GB-189720264-A (GB)
Title: Improvements relating to Stop Mechanism for Organs.
Inventor: BRINDLEY CHARLES FREDERICK
Filed: 1897-09-03
Granted: 1898-08-06
Abstract: 20,264. Brindley, C. F. Sept. 3 Organs.-Relates to keys for actuating stops. The valve is connected at V to a black key B which closes it w h e n depressed. A white key W is connected to the black one in the manner shown, and opens the valve when depressed, and comes into contact with the black one, which thus acts as a stop for it. In a modification, the black key is above and the white key below.
Patent GB-189723528-A (GB)
Title: Improvements in Appliances for Controlling and Regulating the Engines of Motor Cycles and Carriages.
Inventor: HOLDEN HENRY CAPEL LOFFT
Filed: 1897-10-13
Granted: 1898-08-06
Abstract: 23,528. Holden, H. C. L. Oct. 13. Motor road vehicles.-Relates to means for controlling the engines of motor cycles and carriages without removing the hands from the steering- handle. On the steering-spindle D is mounted a vertically-sliding collar F, connected to the valvebox A in which the engine-regulating appliance is situated. The collar F is adjusted by means of a lever H mounted on the handle-bar and provided with a holding-device at K.
Patent GB-189725089-A (GB)
Title: Improvements in or relating to Automatic Coin-freed Apparatus.
Inventor: BOULT ALFRED JULIUS
Filed: 1897-10-29
Granted: 1898-01-22
Abstract: 25,089. Boult, A. J., [Schladitz, H. W.]. Oct. 29. Sale apparatus; actuating-mechanism; coin action ; delivery mechanism. -A central pillar 2 supports by means of a crosshead 3 with pillars 4 a column of rectangular articles piled so that each pair makes a cross among four pillars or angle-pieces d rising from a disc D which is supported from a sleeve 5 on the central pillar. This sleeve 5 is geared to a spring or weight motor controlled by a flyer which is normally held by a detent H, Figs. 5 and 6. A coin momentarily disengages the detent from the flyer, and it can only stop the flyer when one of four notches in a cam 31 on the sleeve registers with its cross-pin 30. Thus the sleeve makes a quarter of a revolution for each coin, and the lowest article drops between the stationary pillars 4 on to a delivery slope E. To ensure the quarter revolution, a hanging hook I holds the cross-pin of the detent, as shown in Fig. 6, till displaced by one of four arms 3, 3 on the sleeve.
Patent GB-189725265-A (GB)
Title: Improvements in and relating to Regenerative Furnaces, for the Heating of Gas Retorts and the like.
Inventor: HELPS GEORGE
Filed: 1897-11-01
Granted: 1898-11-01
Abstract: 25,265. Helps, G. Nov. 1. Retort furnaces.-Figs. 1 and 2 show respectively cross and longitudinal sections of a regenerative gas-producer furnace for heating gas retorts. The gases from the producer A pass into conduits T, T formed in the arch G. From these conduits they pass into a distributing-chamber K, and thence by tapered openings N, N, such as are described in Specification No. 17,530, A.D. 1896, to meet the secondary air supply from the ports P, P. They then pass between the walls 0, round the retorts to the exit Q, and through the regenerative arrangements under the retorts. The two sets of retorts may be separated by a vertical wall so that one set only may be in use at any time. In a modification, the gases pass from the distributing - chamber through central openings in place of through the side ones shown.
Patent GB-189726897-A (GB)
Title: Improvement relating to Cycle-saddles.
Inventor: RAUHE CARL
Filed: 1897-11-17
Granted: 1898-10-15
Abstract: 26,897. Rauhe, C. Nov. 17. Saddles; saddle springs.-The invention is shown as applied to a bicycle. The base of the saddle consists of a single or divided block S, Figs. 1 and 3, arranged transversely and supported by a jointed lever or levers L and a helical spring or springs R. The block may be fitted with a pneumatic or other cushion, which is sometimes divided centrally.
Patent GB-189802128-A (GB)
Title: Improvements in Driving Chains.
Inventor: MORSE EVERETT FLEET
Filed: 1898-01-26
Granted: 1898-09-17
Abstract: 2128. Morse, E. F. Jan. 26. Driving-chains.- The joint described in Specifications No. 20,052, A.D. 1893, and No. 11,923, A.D. 1896, is applied to roller chains. The Figures show two arrangements.
Patent GB-189809587-A (GB)
Title: Improvements in Channelling Machines for Use in the Manufacture of Boots and Shoes.
Inventor: BRAY MELLEN
Filed: 1898-04-26
Granted: 1898-11-05
Abstract: 9587. Lake, H. H., [Bray, M.]. April 26. Channelling soles. Fig. 2 shows a side elevation of a channelling-machine in which the work is fed, by a rotating disc I, past a stationary knife d which makes a shallow incision. This incision is deepened by a knife 3, which is vibrated in a vertical plane by a bell crank P, P<1> operated by an eccentric pin E in the end of the driving-shaft. A worm F on this shaft drives a wheel H mounted on a feather on the feed-shaft G. The disc I is held up to the work by a spring K, but can be eased off by a treadle actuating a lever M. J and 0 are rotating guide-rollers. The latter is mounted on a carriage N, which can slide in vertical guides on the machine frame. This carriage also carries the presser-foot e and the brackets m<1> in which the bell crank P, P' is mounted. The carriage can be raised by a treadle acting through a cam and a pin projecting from one side, and is pulled downwards by a spring. The portion P' of the bell crank is pivoted to the other P at 2, and can be fixed at any required inclination to it by a screw. Fig. 8 shows the knife held in a slot in the piece P' by a plate 7 on which is formed a projection 8 which opens up the channel as shown in Fig. 13.
Patent GB-189812587-A (GB)
Title: An Improvement in Boby Screens.
Inventor: MUMFORD CHARLES EDWARD
Filed: 1898-06-04
Granted: 1898-08-06
Abstract: 12,587. Mumford, C. E. June 4. Screening grain &c.-Relates to reciprocating screens, such as are described in Specification No. 1134, A.D. 1867, for separating grain and seeds, and which, as shown in longitudinal section in Fig. 3 and in plan in Fig. 4, consist of a number of parallel wires W held in transverse bars B connected at their ends to side bars A, in which are slots a through which pass the ends of rods R on which are mounted discs C which stand up between the wires W to keep the spaces between them clear. The ends of the rods R rest in notches n made in the upright limb of an angle-iron N, which is fixed on the framing of the machine, and this invention consists in making the sides F of the reciprocating screen with grooves G on their inner faces at intervals corresponding with those of the notches n, so that the screen with its rods R can be lifted from the end parts of the frame and another be inserted in its place.
Patent GB-189816377-A (GB)
Title: Improvements in Saddles for Horses.
Inventor: TEMPLER CYRIL FRANK
Filed: 1898-07-27
Granted: 1899-07-22
Abstract: 16,377. Templer, C. F., [Elliott, E. L.]. July 27. Saddles, riding. Relates to military &c, saddles which may be readily taken to pieces or repaired without skilled labour. The steel side bars B, with hinged ends B<1> and padded at b, are united by steel &c. arches A, A<1> with cylindrical feet a, a<1> turning freely in sockets C, C' fixed to the side bars. The feet are kept in the sockets by the tension of the leather seat, which is stretched across the arches A, A' and united thereto by buckled straps. Loops D, E for the stirrup leathers and girths G respectively are arranged in the position shown. The flaps are suitably suspended from the side bars.
Patent GB-189820973-A (GB)
Title: An Improved Ointment.
Inventor: JAGELS KATE
Filed: 1898-10-05
Granted: 1898-11-26
Abstract: 20,973. Jagels, K., and Redfern, C. Oct. 5. Ointments.-An ointment for the treatment of old wounds, boils, abscesses, festerings, sores, poisoned wounds, &c. is composed of cerate of calamine, emplastrum resinae (resin plaster), emplastrum minio rubrum (red lead plaster), emplastrum plumbi (lead plaster), and sweet oil, mixed together in specified proportions.
Patent GB-189821067-A (GB)
Title: Improvements in or relating to Apparatus for use in the Production of Oxygen or other Gases.
Inventor: BROWN FREDERICK
Filed: 1898-10-06
Granted: 1900-01-06
Abstract: 21.067. Brown, F., and Stedman, F. J. Oct. 6. Oxygen.-In an apparatus for producing oxygen and other gases by the action of heat on a chemical body, separate charges of the body are moved automatically and successively above the flame. A base-board A has fixed on it guide uprights A', along which run rollers A<4> connected to a second board A', rising and falling as the collapsable gas bag B, which is provided with a central rubber band B<1>, is filled or emptied with gas. The top board carries the generating-apparatus, consisting of a box C, having at one end a tube C<8>, into which a number of the cartridges or cakes of the chemical are placed, and from the lower part of which they are moved forwards over the lamp D by a cam mounted upon the shaft E. This shaft is operated to move the cam by means of a lever G adjustably mounted upon the shaft, the end of the lever resting upon or in the puide A<7> in such a manner that, as the generating-apparatus rises in consequence of the holder filling with gas, the cam is moved away from the cartridge, a spring H ensuring this movement, while, as the generating-apparatus falls, the lever causes the cam to move inwards and force the next cartridge over the flame. A rod C<12> rests upon the cartridges, and is marked with indicating-numerals, so that the operator can see how many cartridges are still unused. The used cartridges are pushed forwards to the receptacle C<1>. The generated gas passes through the tube C<7> to the gas holder, and leaves the holder by the outlet A<5>. Instead of a cam, a plunger, rack and pinion, lever or levers, spring or springs, or other means may be adopted for feeding the cakes forwards, and the feeding-tube may be differently arranged. The feeding - mechanism may be operated by clockwork or other means.
Patent GB-189821956-A (GB)
Title: Improvements in or relating to Vehicle Wheel Rims of Wood.
Inventor: VAUGHT JAMES CHARLES HOSKINS
Filed: 1898-10-18
Granted: 1899-10-18
Abstract: 21,956. Vaught, J. C. H. Oct. 18. Felloes or rims ; spokes.-The ends of the parts s 1 and 2 of the wooden rim of a wagon &c. wheel are cut and put together as shown, the part 1 having a hole to receive the tenon 5 of the spoke 6, and the whole being held together by a dowel-pin 7 entering holes in the rim and spoke. In the case of light wheels for buggies, sulkies, and carriages, a plate R, with flanges 9, is attached at the joint as shown.
Patent GB-189824093-A (GB)
Title: Acetylene Gas Generator.
Inventor: WILLIAMS DAVID SAMUEL
Filed: 1898-11-15
Granted: 1899-04-01
Abstract: 24,093. Williams, D. S. Nov. 15. Acetylene.-A generator is formed of an outer casing A, within which is suspended from the cover a bottomless carbide-containing vessel B, having its lower edge slotted. Suspended from the vessel B by rods c is a conical grate C, forming, along with the annular sloping grate E attached to the casing A, an annular receptacle D into which the carbide falls, and whereon it is acted upon by water admitted through spraying-nozzles on an annular pipe F leading from the main G. The gas escapes through the pipe I, while the residual lime falls through the grate to the bottom of the casing, from which it can be washed out through the valve h by water from the main G and valve g. The supply of water is regulated by a valve f<1> on the supply pipe, the valve being connected by a spring-actuated rod m<2> to the diaphragm m<1> of a valve M<1>. The other side of the diaphragm is placed in communication with the gas space of the generator by the pipe M, so that, as the pressure varies, the supply of water is caused to vary. In the large form of generator shown, the carbide vessel B is charged without any loss of gas from an upper tank K having a trap door K<1> controlled by a chain L' and windlass L. In a smaller form, there is no feeding-reservoir corresponding to the tank K, and the inlet of water is regulated by a floating valve in a fixed side tank in communication with the lower water space of the generator. To this tank is fitted an outlet leading to the outer air, through which gas can escape in case of failure of the valve &c., while a siphon tube prevents any escape of gas into the room.
Patent GB-189824915-A (GB)
Title: An Improved Method of and Apparatus for Facilitating the Shaving or Reducing the Surface of Skins or other Substances or Materials of the like kind.
Inventor: PULLMAN EDWARD ENGLAND
Filed: 1898-11-25
Granted: 1899-10-28
Abstract: 24,915. Pullman, E. E. Nov. 25. Hides and skins, raw or tanned, treating.-In machines for shaving or reducing the surface of skins or other materials by the use of revolving cylinders bearing helical or other blades on their surface, the skin &c. is prevented from being drawn round the blades by the induced current of air, and from being thereby entangled and injured, by the use of a tube arranged near and parallel to the knife cylinder, and having a longitudinal slit from which a current of air is so directed as to neutralize the current induced by the revolving blades.
Patent GB-189826236-A (GB)
Title: Valves for Pneumatic Tires.
Inventor: PICKETT EDWARD FORBES
Filed: 1898-12-12
Granted: 1899-11-11
Abstract: 26,236. Pickett, E. F. Dec: 12. Tyres, pneumatic.-Relates to an inflating-valve which has no direct connection with the wheel rim B, one form being shown in section in Fig. 2. To one side of the air tube A a rubber valve tube C is secured by flaps c, c<1>, and within this tube lies a rubber valve stem f which has at its ends valves e, e<1> seating on the conical ends of the valve tube. The nozzle g of the inflator G has an extension g<1> which takes between the outer valve e<1> and its seating d<1>, when the tyre has to be inflated. In modifications, the valve stem is replaced by a helical spring or the valve tube may be metallic.
Patent GB-189902941-A (GB)
Title: Improvements in Ironing Machines, commonly known as Skirt and Body Ironers.
Inventor: LANE EDWIN JOHN
Filed: 1899-02-09
Granted: 1900-01-13
Abstract: 2941. Lane, E. J. Feb. 9. Ironing-machines.-Fig. 1 shows a side view. The roller i is supported centrally by a rotary shaft, carried in the extension g of the frame a, and driven from the main shaft j by worm gearing m, n. The heated ironing-bed t is reciprocated horizontally by the connecting-rod u attached to the wheel p, and is provided with a bracket v supported between the rolls v<1>, v<11> on the lever y, and capable of sliding horizontally on the rod w secured to the arm x, which is constrained to move in a vertical plane by the links y', y<11>. The ironing-bed t is raised and lowered by operating the treadle D.
Patent GB-189905431-A (GB)
Title: Improvements in Regulating Valves for Steering Gears.
Inventor: WILLIAMSON JOHN DUNLAP
Filed: 1899-03-13
Granted: 1899-04-15
Abstract: 5431. Williamson, J. D. March 13. Steering-engines; governing and regulating speed and power.-Relates to a regulating-valve for fluidpressure steering-engines which prevents the too great admission of steam to the engine when the rudder is amidships, and offers comparatively little resistance to movement. In Fig. 1, E is the usual starting-valve, governed by the hand-steering wheel. Steam is supplied to the casing of this starting-valve through a regulating-valve G, which is closed when the rudder is amidships. At such times steam is supplied to the valve E by a handregulated bye-pass valve, or by leakage past the valve G, in quantity sufficient to start the engine. As the chain drum B<1> rotates, it opens the regulating-valve by rotating the geared nut g' through the wheels b<3>, b<4>. When the drum is reversed to place the rudder amidships, the valve G is closed.