Patent SG-11201806861S-A (SG)
Title: Combination therapy with anti-cd73 antibodies
Inventor: BARNHART BRYAN
IPC: C07K16/28
Filed: 2017-03-03
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 8 September 2017 (08.09.2017) WIPO I PCT (10) International Publication Number WO 2017/152085 Al 11111111111111011101111111111101011111011101111111101011111H1111111111111110111111 (51) International Patent Classification: C07K 16/28 (2006.01) A61K 39/00 (2006.01) (21) International Application Number: PCT/US2017/020714 (22) International Filing Date: 3 March 2017 (03.03.2017) Filing Language: English Publication Language: English Priority Data: 62/303,985 4 March 2016 (04.03.2016) US 62/305,378 8 March 2016 (08.03.2016) US 62/341,220 25 May 2016 (25.05.2016) US 62/363,703 18 July 2016 (18.07.2016) US 62/431,987 9 December 2016 (09.12.2016) US (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 & Province Line Road, Princeton, NJ 08543 (US). (72) Inventors: BARNHART, Bryan, C.; 700 Bay Road, Red- wood City, CA 94063 (US). KORMAN, Alan, J.; 700 Bay Road, Redwood City, CA 94063 (US). LONBERG, Nils; 700 Bay Road, Redwood City, CA 94063 (US). YAMNIUK, Aaron, P.; Route 206 & Province Line Road, Princeton, NJ 08543 (US). SRIVISAN, Mohan; 700 Bay Road, Redwood City, CA 94063 (US). HENNING, Karla, A.; 700 Bay Road, Redwood City, CA 94063 (US). LEI, Ming; Route 206 & Province Line Rd., Princeton, NJ 08543 (US). SEGA, Emanuela; 700 Bay Road, Redwood City, CA 94063 (US). GOODENOUGH, Angela; 406 Stockham Avenue, Morrisville, PA 19067 (US). JURE- KUNKEL, Maria; Route 206 & Province Line Rd., Prin- ceton, NJ 08543 (US). CHEN, Guodong; Route 206 & Province Line Rd., Princeton, NJ 08543 (US). SACK, John, S.; Route 206 & Province Line Rd., Princeton, NJ 08543 (US). HUANG, Richard, Y.; Route 206 & Province Line Rd., Princeton, NJ 08543 (US). CORBETT, Martin, J.; Route 206 & Province Line Rd., Princeton, NJ 08543 (US). MYERS, Joseph, E. Jr.; Route 206 & Province Line Rd., Princeton, NJ 08543 (US). SCHWEIZER, Liang; Route 206 & Province Line Road, Lawrenceville, NJ 08543 (US). HATCHER, Sandra, V.; Route 206 & Province Line Rd., Princeton, NJ 08543 (US). ALTURA, Rachel; Route 206 & Province Line Road, Princeton, New Yersey 08543 (US). HUANG, Ha- ichun; 700 Bay Road, Redwood City, California 94063 (US). ZHANG, Pingping; 700 Bay Road, Redwood City, California 94063 (US). HILT, Edward, J.; Route 206 & Province Line Road, Lawrenceville, NJ 08543 (US). HEDRICK, Michael, Nathan; Rout 206 & Province Line Road, Lawrenceville, NJ 08543 (US). (74) Agents: REMILLARD, Jane E. et al.; Nelson Mullins Ri- ley & Scarborough LLP, One Post Office Square, Boston, MA 02109-2127 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (25) (26) (30) W O 20 17 / 15 2085 Al (54) Title: COMBINATION THERAPY WITH ANTI-CD73 ANTIBODIES (57) : Provided are methods for clinical treatment of tumors (e.g., advanced solid tumors) using an anti-CD73 antibody in combination with an immuno-oncology agent, such as an anti-PD- 1 antibody.