Patent SG-11201806636S-A (SG)
Title: Treatment and diagnosis of inflammatory disorders
Inventor: ZHU ZHENGLUN
IPC: G01N33/566
Filed: 2017-01-31
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111110111101110101011111010111110111011100110110010111011111101111011111 International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/136322 Al 10 August 2017(10.08.2017) WIPO I PCT (51) International Patent Classification: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, C12N 15/11 (2006.01) G01N 33/566 (2006.01) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, A61K 48/00 (2006.01) C07H 21/04 (2006.01) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, C12Q 1/68 (2006.01) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (21) International Application Number: RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, PCT/US2017/015775 TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (22) International Filing Date: ZA, ZM, ZW. 31 January 2017 (31.01.2017) (84) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (26) Publication Language: English TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (30) Priority Data: TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 62/291,271 4 February 2016 (04.02.2016) US DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventors; and SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (71) Applicants : ZHU, Zhenglun [US/US]; 48 Maplewood GW, KM, ML, MR, NE, SN, TD, TG). Avenue, Newton, Massachusetts 02459 (US). GAO, Hong [US/US]; 886 Williamsburg Blvd., Downingtown, Published: Pennsylvania 19335 (US). — with international search report (Art. 21(3)) (74) Agent: WU, Jeannie; Cesari and McKenna, LLP, 88 Black — before the expiration of the time limit for amending the Falcon Avenue, Boston, Massachusetts 02210 (US). claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (81) Designated States (unless otherwise indicated, for every — with sequence listing part of description (Rule 5.2(a)) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, = 1-1 ei ei cr) cr) 1-1 (54) Title: TREATMENT AND DIAGNOSIS OF INFLAMMATORY DISORDERS 1-1 C (57) : A method of treating an inflammatory disorder in a subject, comprising administering to the subject in need thereof a N nucleic acid molecule for inhibiting the expression of Hom-1. Specifically, the nucleic acid molecule is an RNAi agent or an antis - O ense morpholino oligonucleotide. Further disclosed is a method of selecting a therapeutic for an inflammatory disorder in a subject, or monitoring the efficacy of a therapeutic for an inflammatory disorder in a subject, comprising detecting the expression level of Hom-1 in an inflamed tissue sample obtained from the subject.