baber/WOPTO huggingface dataset:
Patent CA-2590533-C (CA)
Title: 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia
Inventor: CHOI CHULHO
IPC: C07D231/14
Filed: 2005-11-14
Granted: 2010-09-07
Abstract: The present invention provides compounds of the formula (I), (IV) and (V) and intermediates of the formuale (VI) and (VII): (I), (IV), (V), (VI), (VII).  wherein: R1 is hydrogen, halogen, C1-C7 alkyl, C3-C8 cycloalkyl, aryl, aralkyl, heteroaryt, or heteroaralkyl; more specifically, R1 is C1-C7 alkyl or C3-C8 cycloalkyl; even more specifically, R1 is isopropyl; where alkyl, cycloalkyt, aryl, aralkyt, heteroaryl, or heteroaralkyl of R1 is optionally substituted, R2 is hydrogen, halogen, C1-C7 alkyl, C3-C8 cycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, NC-, R2bR2aNCO(CH2)n -, R2bR2a NS(O)n-, R2cS(O)n-, R2bR2a N(CH2)n-, R2b-J-C(O)NR2a(CH2)n-, R2b-J-~SO2NR2a(CH2)n-, R2b-J-SONR2a(CH2)n, R7OOC(CH2)n-, or R7CO(CH2)n-; more specifically, R2 is R2bR2aNCO(CH2)n-; even more specifically, R2 is R2bR2a NCO-; where alkyl, cycloalkyl, aryl , aralkyl, heteroaryl, or heteroaralkyl of R2 is optionally substituted, R3 is hydrogen, C1-6 aikyl, C3-6necycloafkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl; more specifically, R3 is aryl; even more specifically, R3 is phenyl or p-fluorophenyl; where alkyl, cycloalkyl, aryl, aralkyl, heteroaryt, or beteroaralkyd of A3 is opltianally substituted and is a bond or is absent. The other substituents are defined in the claims. The present invention relates to compounds and pharmaceutical compositions useful as hypocholesterolemic and hypolipidemic agents. Moree specifically, the present invention concerns certain potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase ("HMG CoA reciuctase"). The compounds are useful for the treatement of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, Alzheimer's Disease, benign prostatic hypertrophy (BPH), diabetes and osteoporosis.
Patent CA-2591853-C (CA)
Title: Kilt hanger
Inventor: AUSTIN JOSEPH E
IPC: A47G25/16
Filed: 2007-06-18
Granted: 2010-12-21
Abstract: A kilt hanger for accommodating a kilt and kilt accessories is disclosed. The kilt hanger includes a frame defining two arms and three horizontal members. A kilt is folded into thirds or three panels and connected to the kilt hanger using a pair of clasps or clips on each horizontal member. Accordingly, each panel of the folded kilt is connected to a different horizontal member with a center panel of the kilt connected to a central horizontal member and each other panel connected to an outer horizontal member. The outer horizontal members are positioned higher on the arms than the central horizontal member. A vest and jacket can also be placed on the kilt hanger along with a fly plaid that is draped over an optional horizontal dowel member. Methods of using and fabricating the kilt hanger are also disclosed.
Patent CA-2593181-C (CA)
Inventor: PFENNIGHAUSEN SCOTT B
IPC: G07C9/00
Filed: 2005-12-02
Granted: 2015-11-24
Abstract: A method and apparatus for use in a wagering environment is disclosed. An exemplary embodiment of the present invention comprises a wagering terminal including a processor, a memory, a primary display, and a secondary display. The primary display is configured for displaying visual messages. These visual messages are displayed are displayed as part of a graphical user interface and include at least one wagering transaction message. The secondary display is configured for displaying additional visual messages associated with the visual messages of the primary display. These additional visual message are displayed as part of an additional graphical user interface. The wagering terminal may further include a proximity detector configured for detecting the presence of a gaming patron, a user identification unit configured for sampling a unique physical attribute of a user, and an image capture unit configured for capturing at least one image in a vicinity of the wagering terminal.
Patent CA-2603696-C (CA)
Title: Filter press with novel filter cake release mechanism
Inventor: SCHULTE HORST CHRISTIAN
IPC: B01D25/172
Filed: 2006-04-03
Granted: 2011-06-14
Abstract: The invention provides a filter press comprising a support frame; a plurality of filter plates mounted adjacent one another on the support frame, the filter plates being displaceable between an inoperative position wherein adjacent filter plates are spaced apart, and an operative position wherein adjacent filter plates abut to form filtration cavities between them; the filter plates in their inoperative position being angularly displaceable relative to the support frame; and actuating means adapted angularly to displace the filter plates relative to the support frame so as to discharge filter cake from the filtration cavities.
Patent CA-2606738-C (CA)
Title: Anchor system for concrete construction and method thereof
Inventor: MAGNESIO CHARLES
IPC: E04B1/41
Filed: 2007-10-16
Granted: 2011-01-04
Abstract: An anchor system and method to provide support in concrete construction including a concrete-embeddable body having an aperture, one or more concrete anchor legs situated on a first plane, and one or more concrete anchor members situated on a second plane that is different from the first plane, and a strap having a matable head and an elongated strap body, wherein the matable head of the strap lockingly engages the aperture of the concrete-embeddable body.
Patent CA-2606885-C (CA)
Inventor: EICHER JOACHIM
IPC: A61M37/00
Filed: 1996-07-15
Granted: 2009-10-06
Abstract: The invention provides a micro-pin for administering a drug solution from a reservoir of the drug solution, wherein the micropin is at least 10 µm long.
Patent CA-2609871-C (CA)
Title: Wound-in tenon / wound-in tenon collar for attachment of luminaire
Inventor: COPELAND S DOUGLAS
IPC: F21V21/116
Filed: 2007-11-02
Granted: 2010-09-21
Abstract: A modular pole system for a luminaire includes an elongated pole section formed from a continuous filament winding process with a tenon or tenon collar wound into a tip end of the pole section. A method for making a modular pole system includes placing a tenon or tenon collar over a trunion end of a mandrel and winding a pre-selected thickness of a filament along the length of the mandrel up to and including a pre-selected length of the tenon or tenon collar to produce a tenon or tenon collar wound into a pole section of the modular pole system. 22
Patent CA-2610345-C (CA)
Inventor: COLLINS JEFFREY
IPC: G16H50/20
Filed: 2006-06-02
Granted: 2013-12-24
Abstract: The invention provides a system and method for computer-aided detection ("CAD"). The invention relates to computer-aided automatic detection of abnormalities in and analysis of medical images. Medical images are analyzed, to extract and identify a set of features in the image relevant to a diagnosis. The system computes an initial diagnosis based on the set of identified features and a diagnosis model, which are provided to a user for review and modification. A computed diagnosis is dynamically re-computed upon user modification of the set of identified features. Upon a user selecting a diagnosis based on system recommendation, a diagnosis report is generated reflecting features present in the medical image as validated by the user and the user selected diagnosis.
Patent CA-2612250-C (CA)
Title: A method and apparatus for adaptive registration and paging area determination
Inventor: PRAKASH RAJAT
IPC: H04W60/04
Filed: 2006-06-16
Granted: 2014-11-25
Abstract: Accordingly, a method adaptive registration is disclosed, wherein the access terminal adjusts the registration area based on mode and its location.  Accordingly, the network also adjusts its paging area. Generally, the access terminal will transition from small registration area to large registration area based on its mobility.
Patent CA-2617093-C (CA)
Inventor: PELAK WYNN M
IPC: B65G47/22
Filed: 2008-01-08
Granted: 2017-04-25
Abstract: An article singulating conveyor assembly and method of singulating articles includes providing a conveying surface defining a plurality of tandem zones. The conveying surface travels in a longitudinal direction. Each of the zones includes a pair of laterally spaced side frame members and a plurality of generally parallel elongated driven rollers that are supported at the side frame members. The driven rollers are adapted to provide lateral variation in the longitudinal speed of the conveying surface. Each of the zones includes at least one drive motor that is adapted to drive the driven rollers in that zone. At least one article sensor is provided that is adapted to sensing articles in the zones. The driven rollers may be divided into a plurality of segmented rollers that are separately rotatable with a separate drive motor to drive corresponding segments for a zone. The drive motors for adjacent zones may be activated in a manner that creates a longitudinal gap between longitudinally adjacent articles.
Patent CA-2617349-C (CA)
Inventor: GRADON LEWIS GEORGE
IPC: F24F6/00
Filed: 1998-06-16
Granted: 2011-11-15
Abstract: A flow probe for use in a humidification system is disclosed. The flow probe is adapted to be positioned in a humidified gases flow (for example oxygen or anaesthetic gases) such as that which is provided to a patient in a hospital environment. The flow probe is designed to provide both temperature and flow rate sensing of the gases flow by incorporating two sensors (preferably thermistors) and the shape and alignment of the probe enables accurate readings by reducing the occurrence of condensation on the sensors. A number of possible applications are disclosed wherein the flow sensor is included in humidification control systems which provide a patient with a desired humidity level or simplify the amount of user input required or wherein the flow sensor provides a controller with flow information which may then be used to determine certain, possibly dangerous, conditions (such as incorrect flow sensor placement, breathing circuit disconnected, no water in the humidification chamber or humidity out of required limits).
Patent CA-2619191-C (CA)
Inventor: WAELCHLI URS
IPC: G01L11/02
Filed: 2006-07-18
Granted: 2014-05-27
Abstract: A manufacturing method for a vacuum measuring cell provides first and second Al2O3 ceramic or sapphire housing bodies on opposite sides of an Al2O3 ceramic or sapphire membrane sealed to the bodies at its opposite peripheral edges. A  reference vacuum chamber and a measuring vacuum chamber are on opposite sides of the membrane. An optical transparent window is provided in the first housing body and an optically reflective material is provided on a central region of the membrane.  A lens is above the optical transparent window for optically linking to the optically reflective material on the membrane and an optical fibre outside the reference vacuum chamber and at a distance from the optical transparent window feeds light through the lens and window and in and out onto the optically reflective material on the membrane so that the level of membrane deflection is detected by a Fabry-Perot Interferometer.
Patent CA-2620812-C (CA)
Inventor: LACOMBE BERTRAND
IPC: H02M1/00
Filed: 2008-02-12
Granted: 2014-10-21
Abstract: Afin de diminuer le coût d'un convertisseur à découpage fournissant une tension continue aux bornes d'une charge (Z), il est proposé, selon la présente invention, un circuit à deux enroulements (Lp, Ls) et un seul noyau magnétique, ce qui permet de diminuer le coût et la taille du circuit. Il est alors nécessaire d'ajouter deux diodes (D3, D4) au circuit, mais ces éléments sont de faible coût et de faible encombrement.
Patent CA-2620915-C (CA)
Title: Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
Inventor: ADELMAN DANIEL C
IPC: A61P35/02
Filed: 2006-09-05
Granted: 2014-03-25
Abstract: Methods of treating, preventing or managing cancer, including certain leukernias are disclosed. The methods encompass the administration of enantiomerically pure (+)-l,4- dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-l-pyrrolidinyl]-4-oxo-l-(2-thiazolyl)-l,8- naphthyridine-3-carboxylic acid. Also provided are methods of treatment using this compound with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods are also disclosed.
Patent CA-2626828-C (CA)
Title: Element de retenue de cellule electrochimique, enceinte correspondante, systeme electrochimique et connecteur de cellules electrochimiques
Inventor: OKUMURA KIYOSHI
IPC: H01M8/02
Filed: 2002-09-12
Granted: 2010-03-09
Abstract: L'invention concerne une structure d'assemblage destinée à faciliter l'assemblage de cellules uniques laminées, à réduire la possibilité de fuite de gaz après des cycles répétés d'élévation et de baisse de température et à prévenir la réduction de l'efficacité des cellules en raison de la fuite de gaz. Une cellule électrochimique en forme de plaque (9), composée de matériau céramique et dotée d'un trou traversant (9a), est maintenue par un élément de retenue (1). L'élément (1) est composé de matériau céramique et possède un corps principal (1a) en forme de plaque plane et une partie saillante (1b) qui s'étend du corps principal (1a). Un premier trou d'alimentation (2A) destiné à distribuer un gaz et un deuxième trou d'alimentation (2B) destiné à distribuer l'autre gaz sont formés dans l'élément de retenue (1). Le corps principal (1a) possède une surface d'étanchéité (1c) contre la face principale (9a) de la cellule (9), alors que la partie saillante (1b) est insérée dans le trou traversant (9a).
Patent CA-2630530-C (CA)
Inventor: ATAMAN-ONAL YASEMIN
IPC: A61K47/48
Filed: 2006-10-17
Granted: 2016-03-29
Abstract: The invention relates to pharmaceutical compositions containing a colloidal synthetic bioresorbable vector which comprises at least one type of proteinic substance, to a viral vector corresponding to at least one type of proteinic substance of the synthetic vector and to a method for the prophylactic, therapeutic and diagnosis use thereof.
Patent CA-2634127-C (CA)
Inventor: SIES HELMUT
IPC: A61K36/74
Filed: 2006-12-21
Granted: 2016-06-07
Abstract: This invention relates to compositions, and methods of use thereof, for (i) reducing ultraviolet (UV)-induced skin erythema and/or photoaging, and for (ii) improving skin quality, each method comprising orally administering to a subject in need thereof, certain polyphenols such as flavanols, procyanidins, or pharmaceutically acceptable salts or derivatives thereof.
Patent CA-2637344-C (CA)
Inventor: THOMPSON ROBERT KIRK
IPC: C08G65/30
Filed: 2006-02-03
Granted: 2013-10-29
Abstract: Polyalkylene glycol compositions having reduced low molecular weight oligomers are disclosed. Some compositions, particularly polyethylene glycol compositions have a number average molecular weight range from about 3000 to about 10,000 g/mol and have a total oligomer concentration of less than about 400 ppm of all oligomers having a molecular weight of less than or equal to 812 g/mol and a a total oligomer concentration of less than about 50 ppm of all oligomers having a molecular weight of less than or equal to 240 g/mol. Other polyalkylene compositions, particularly polyethylene glycol compositions, are characterized by a total oligomer concentration of less than about 90 ppm of all oligomers having a molecular weight less than or equal to 460 g/mol and are obtained without further processing to remove oligomers having a molecular weight of less than about 460 g/mol. Methods for making such compositions are also disclosed.
Patent CA-2646012-C (CA)
Inventor: WELLS LAWRENCE E
IPC: E21B3/02
Filed: 2007-04-05
Granted: 2012-06-05
Abstract: A top drive apparatus for wellbore operations, the top drive apparatus comprising a main body (24a), a motor apparatus, a rotatable member (18) and a gear system driven by the motor apparatus for rotating the rotatable member, a sealing assembly (10a) for providing a lubricant tight seal about the rotatable member (18), the sealing assembly (10a) comprising a seal carrier (20a) adjacent the rotatable member (18), a primary seal (14) on or in the seal carrier (20), the primary seal (14) sealingly contacting a perimeter of the rotatable member (18), at least one secondary seal (34) on or in the seal carrier (20) , the secondary seal (34) spaced from the rotatable member (18), the seal carrier (20) selectively movable to move the at least one secondary seal (34) into sealing contact with the rotatable member.
Patent CA-2646518-C (CA)
Title: Apparatus and method for performing a bypass procedure in a digestive system
Inventor: NOLAN TIM
IPC: A61B17/11
Filed: 2001-03-05
Granted: 2011-01-18
Abstract: An anvil delivery instrument which comprises: an elongated outer member defining a general longitudinal axis and having proximal and distal ends, and defining a longitudinal bore; a pivot member at least partially disposed within the longitudinal bore of the outer member, the pivot member adapted for longitudinal movement within the outer member; and an anvil mounted to the outer member and operatively connected to the pivot member, the anvil including an anvil rod and an anvil head pivotally mounted to the anvil rod, the anvil head pivotally movable from a non--operative position to an operative position upon longitudinal movement of the pivot member, the anvil rod being mountable with respect to an end to end anastomosis instrument.
Patent CA-2658376-C (CA)
Inventor: ZEMOLKA SASKIA
IPC: C07D307/81
Filed: 2007-07-17
Granted: 2015-03-24
Abstract: The invention provides substituted heteroaryl derivatives of the formula (see formula I) and to methods for the production thereof. The compounds of the invention may be used to affect a patient's opioid receptor system, and the ORL-1 opioid receptor and the µ opioid receptor in particular.
Patent CA-2658566-C (CA)
Inventor: O'NEIL DAVID GILES
IPC: G06K9/64
Filed: 2007-06-28
Granted: 2013-02-12
Abstract: Systems and methods for assisting in the determination of the authenticity of security documents based on known characteristics of similar but authentic security documents. The system and methods use digital processing to capture a digital image of the document being examined and they use a feature localization or detection technique to search for a specific feature in the document based on a stored image of a similar feature from an authentic document. Once the feature on the subject document has been found, the digital image of the localized feature is transformed, by applying mathematical transforms or other image/mathematical operators, such that the result will have distinguishing characteristics that can be derived or analyzed. When the distinguishing characteristics have been analyzed, these are then compared to the stored distinguishing characteristics of similar features from known authentic documents. Based on the comparison, a score is then generated that is indicative of how similar or how different the distinguishing characteristics of the feature being examined are from the features from known authentic documents. The system may also be used such that multiple features from a single document are assessed and scored separately from one another with a final aggregate or weighted score being provided to the user for the whole document.
Patent CA-2659358-C (CA)
Inventor: KOOPMAN CARLOS NICOLAAS JOZEF MARIA
IPC: A47J31/40
Filed: 2007-07-26
Granted: 2015-03-17
Abstract: The invention relates to a mixing device (2) for mixing a liquid, such as water, with an instant ingredient to form a beverage. The mixing device (2) comprises a mixing chamber (13,16,24) and a rotor (25). The mixing chamber (13,16,24) comprises an inlet chamber (13), a rotor chamber (24) and a pipe bend (16). The inlet opening (29) of the pipe bend (16) extends in the horizontal plane. The rotor (25) is provided in the rotor chamber (24). The internal wall of the pipe bend (16) has, on the side of the outer curve (11), a planar surface (37) which is defined by a first direction (H) and a second direction (D). The first direction (H) extends in the horizontal direction and the second direction (D) extends at right angles to the first direction (H), at an angle to the horizontal plane. The planar surface (37) is situated perpendicularly below the inlet opening (29) of the bend (16).
Patent CA-2659864-C (CA)
Title: Gel insole
Inventor: GRISONI BERNARD F
IPC: A43B13/18
Filed: 2007-08-02
Granted: 2013-02-05
Abstract: An insole for insertion into footwear, comprising a forefoot portion, a midfoot portion and a heel portion; the midfoot portion connecting together the forefoot portion and the heel portion; said insole comprising a cushioning layer of a viscoelastic gel material which provides a cushioning function; and wherein the midfoot portion and the heel portion comprise a peripheral edge that curves upwards.
Patent CA-2661647-C (CA)
Inventor: SHIMIZU NORIAKI
IPC: C12N5/10
Filed: 2007-08-20
Granted: 2013-02-05
Abstract: A vector of the present invention is a vector for amplifying a target gene in a mammalian cell, the vector including an amplification-activating fragment, which is a partial fragment of a mammalian replication initiation region and has a gene amplification activity site, and a mammalian nuclear matrix attachment region. In the case where the mammalian replication initiation region as described above derives from a c-myc locus, for example, the above-described partial fragment at least contains a duplex unwinding element and a topoisomerase II-binding domain. The vector as described above improves gene transfer efficiency and gene amplification efficiency compared with the existing high gene amplification systems. Thus, a method whereby a "high gene amplification system" developed by the inventors can amplify a target gene with better gene transfer efficiency and a vector to be used in this method are provided.
Patent CA-2662290-C (CA)
Title: Synthese et separation par microcanaux integres
Inventor: TONKOVICH ANNA LEE Y
IPC: C01B3/02
Filed: 2007-09-05
Granted: 2012-10-30
Abstract: L'invention concerne un procédé permettant d'exécuter deux opérations élémentaires en série, le procédé est constitué de l'étape (a) diriger une vapeur de distributeur dans un ensemble intégré qui comprend une première opération élémentaire par microcanaux sur au moins un produit chimique de la vapeur du distributeur pour générer une vapeur de sortie répartie qui sort de la première opération élémentaire par microcanaux, et de l'étape (b) diriger la vapeur de sortie répartie dans une seconde opération élémentaire par microcanaux sous forme d'une vapeur répartie d'entrée afin de continuer d'isoler l'écoulement entre le premier ensemble de micros canaux discrets et conduire au moins une opération sur au moins un produit chimique de la vapeur d'entrée pour générer une vapeur de produit qui sort de la seconde opération élémentaire par microcanaux, la première opération élémentaire par microcanaux et la seconde opération élémentaire partageant un même boîtier.
Patent CA-2664495-C (CA)
Inventor: VIOLA FRANK J
IPC: A61B17/94
Filed: 2007-10-05
Granted: 2015-06-02
Abstract: A handle assembly for operating a surgical instrument is provided and includes a housing; a trigger operatively supported on the housing; and at least one actuation cable operatively associated with the trigger and extending from the housing in such a manner that an actuation of the trigger imparts both an axial translation of the actuation cable and a rotation to the actuation cable. Each of the axial translation and rotation of the actuation cable performs a separate function.