baber/WOPTO huggingface dataset:
Patent CR-20180255-A (CR)
Title: Derivados de indolin-2-ona
Inventor: HALM REMY
IPC: C07D403/14
Filed: 2016-11-02
Abstract: La presente invención se refiere a derivados de indolin-2-ona de fórmula general en donde los sustituyentes se definen en la reivindicación 1. Los compuestos pueden usarse en el tratamiento de enfermedades del SNC relacionadas con síntomas positivos (psicosis) y negativos de la esquizofrenia, abuso de sustancias, alcohol y drogadicción, trastornos obsesivo-compulsivos, deterioro cognitivo, trastornos bipolares, trastornos del estado de ánimo, depresión mayor, depresión resistente al tratamiento, trastornos de ansiedad, enfermedad de Alzheimer, autismo, enfermedad de Parkinson, dolor crónico, trastorno límite de la personalidad, enfermedad neurodegenerativa, alteraciones del sueño, síndrome de la fatiga crónica, rigidez, enfermedad inflamatoria, asma, enfermedad de Huntington, ADHD, esclerosis lateral amiotrófica, efectos en la artritis, enfermedad autoinmunitaria, enfermedades víricas y fúngicas, enfermedades cardiovasculares, enfermedades oftalmológicas e inflamatorias de la retina y problemas de equilibrio, epilepsia y trastornos del neurodesarrollo con epilepsia comórbida.
Patent CR-20180408-A (CR)
Title: Composición farmacéutica que copmprende constructos de anticuerpo biespecíficos
Inventor: KANAPURAM SEKHAR;
IPC: C07K16/28
Filed: 2017-01-25
Abstract: La presente invención provee composición farmacéuticas nuevas y estables que comprenden constructos de anticuerpo biespecíficos de cadena simple, ciclodextrinas y un buffer
Patent CR-20190407-A (CR)
Inventor: DEVITO JOHN PETER
IPC: C11B9/02
Filed: 2018-02-27
Abstract: Se proporciona un ensamblaje transportador y de lavado superior para un extractor de aceite da cítricos. En una forma de realización, un colector de pulverización se conecta a una cadena de transmisión y tiene boquillas para aplicar una solución de limpieza y agua a los rodillos del extractor. Un ensamblaje de barra limpiadora está suspendido pendularmente del colector de pulverización y transporta las frutas cítricas a través del extractor según sea necesario. El ensamblaje de barra limpiadora se mueve a una posición elevada para ser retraído al extremo de entrada del extractor. Una segunda forma de realización usa un colector de pulverización suspendido pendularmente de cadenas de transmisión y transporta cítricos a través del extractor según sea necesario y también pulveriza la solución de limpieza y agua según sea necesario.An overhead conveyor and wash assembly is provided for a citrus oil extractor. In one embodiment, a spray manifold is connected to a drive chain and has nozzles for applying a cleaning solution and water to the extractor rollers. A wiper bar assembly is pendulously suspended from the spray manifold and conveys citrus fruits through the extractor as needed. The wiper bar assembly is moved to a raised position to be retracted to the input end of the extractor. A second embodiment uses a spray manifold pendulously suspended from drive chains and conveys citrus fruit through the extractor as needed and also sprays cleaning solution and water as needed.
Patent EC-SP003767-A (EC)
Title: Metodo para aliviar la ansiedad
Inventor: MAYOL ROBERT F
IPC: C07D239/34
Filed: 2000-11-16
Abstract: La 6-hidroxi-8-[4-[4-(2-pirimidinil)-piperazinil]-butil]-8-azaspiro[4.5]-diona y sus sales e hidratos farmacéuticamente aceptables, son útiles en el alivio de la ansiedad.
Patent EC-SP951498-A (EC)
Title: Nuevos derivados de pirrocarbazol case ran 4121/15
Inventor: BROKA CHRIS ALLEN
IPC: C07D209/56
Filed: 1995-08-03
Abstract: Un compuesto representado por la fórmula: en donde: R1 es hidrógeno o alquilo inferior; R2 es heteroarilo; y R3 yR4 son independientemente hidrógeno o alquilo inferior o una sal farmacéuticamente aceptable respectiva.
Patent FI-20002539-A (FI)
Inventor: PARK JONG SANG
IPC: C12N15/00
Filed: 2000-11-20
Abstract: A compound for targeted gene delivery is provided consisting of polyethylene glycol (PEG) grafted poly(L-lysine) (PLL) and a targeting moiety, wherein at least one free amino function of the PLL is substituted with the targeting moiety, and the grafted PLL contains at least 50% unsubstituted free amino function groups. TM is preferably lactose or galactose which are capable of specifically targeting a hepatoma cell or a liver cell. The new synthetic carriers with various substitution ratios of targeting moiety-PEG were characterized using NMR spectroscopy. The new polymeric gene carriers of this invention are capable of forming stable and soluble complexes with nucleic acids, which in turn are able to efficiently transform cells. PEG attached to the PLL gives better solubility properties to the gene/carrier complex and improved transfection efficiency without considerable cytotoxicity. Methods of preparing and using the targeting moiety-PEG-PLL as gene carriers to efficiently transfect cells are disclosed.
Patent FR-1600962-A (FR)
Title: New prepn of measles virus suspensions
IPC: A61K39/165
Filed: 1968-12-20
Granted: 1970-08-03
Abstract: A cell culture from sheep toetal kidney is inoculated with a measles virus stock which are allowed to grow in a culture medium, and then in a medium which nearly allows cellular degeneration. The viral prods. are then collected and the process repeated pref. 30-50 times until a product having at least 105 IDCT 50/ml titre and a haemoglutination power for monkey red blood cells, is formed. Pref. the stock used is Enders var. Edmonston and the incubation is at pref. 31-35 degrees C. Used in measles vaccines, or as antigens for its detection and antibody doses.
Patent FR-1602741-A (FR)
Title: Non-woven filter material for dust extrac- - tion consists of lightly-needled continuous
IPC: B01D39/16
Filed: 1968-12-30
Granted: 1971-01-18
Abstract: Filter material consists of fleece of continuous fibres laid in zig-zag lines, which is lightly needled and contains small amount of resin (thermosetting or thermoplastic), e.g. thermostable acrylic resins, solutions of natural or synthetic rubbers, PVC, polyethylene, polyurethane etc. 10-50 g. dry resin/m2 fleece is applied by spraying or dipping, after which material is dried and calendered. Material is very porous, strong and resistant to deformation. It is esp. suitable for making dust filter bags.
Patent GB-1047209-A (GB)
IPC: C09B29/08
Abstract: 1,047,209. Water-insoluble mono-azo dyes. FARBENFABRIKEN BAYER A.G. Sept. 13, 1965 [Sept. 18, 1964]. No. 38924/65. Heading C4P. Water-insoluble mono-azo dyes of general formula in which R is a hydrogen atom or a methyl group and R 1  is an alkyl group preferably of 1-4 carbon atoms, are prepared by diazotizing 1 - amino - 2,6 - dichloro - 4 - nitrobenzene and coupling to 1 - N,N bis - (alkoxy - carbonyl - hydroxyethyl), amino-3-methyl benzene or N,N- bis(alkoxy-carbonyl-hydroxyethyl)aniline preferably in acid solution or dispersion. The dyes provide fast brown shades in polyester material.
Patent GB-1047290-A (GB)
IPC: H01J61/067
Abstract: 1,047,290. Thermionic cathodes. LEYBOLD HOLDING A.G. Aug. 20, 1965 [Sept. 10, 1964], No. 35927/65. Heading H1D A thermionic cathode 4, for use in oxygencontaining atmospheres, e.g. in ionization manometers or mass spectrometer tubes, and consisting of metal which forms volatile oxides at elevated temperatures, is suspended between electrode holders 1, 1A through the intermediary of metal members 5, 6, which are insensitive to oxygen and which are so dimensioned that the temperature of cathode 4 remains above the temperature range in which the cathode metal forms oxides. The cathode 4 may be of rhenium and the intermediate members of iridium or platinium-iridium wire which is spot-welded to cathode 4 and holders 1, 1A.
Patent GB-1050231-A (GB)
IPC: C08F220/12
Abstract: 1,050,231. Removable polymer coatings. PITTSBURGH PLATE GLASS CO. Jan. 28, 1964 [Jan. 30, 1963], No. 3515/64. Heading C3P. An article having a rigid, solid, non-porous surface, such as a glass, metal or lacquered metal article, is temporarily protected by applying thereto a water-resistant film of a composition consisting essentially of a copolymer of 10 to 20% by weight of an α,(#-ethylenically unsaturated monocarboxylic acid, and the balance by weight of at least one ester having the formula wherein R<SP>1</SP> is hydrogen or methyl and R is an alkyl group containing from 1 to 8 carbon atoms, optionally containing up to 23% by weight of the total of copolymerizod > C = CH 2  monomer, e.g. styrene or vinyl toluene, and optionally containing a pigment, or of an ammonium or amine salt of the composition, and the film is subsequently removed from the article by the use of a dilute alkaline solution. Acids specified are acrylic and crotonic acids and their alpha- C 1-4 -alkyl derivatives. The composition may be applied as an aqueous solution of the ammonium or amine salt (including hydrazine salt) of the copolymer or as a solution of the copolymer in an organic solvent, which may be an alcohol, alcohol-ether, ester, ketone or aromatic hydrocarbon. In the examples ethyl acrylate, methyl methacrylate and methacrylic acid are copolymerized in the presence of tertiary dodecyl mercaptan in aqueous dispersion using ammonium persulphate as the catalyst. Zinc ammonium acetate or strontium chromate are included in the composition in two of the examples. An alkaline medium for removing the composition is also disclosed.
Patent GB-1050966-A (GB)
IPC: D02G3/22
Abstract: 1,050,966. Filter media. LINDSAY WIRE WEAVING CO. Aug. 8, 1963 [Aug. 10, 1962], No. 31360/63. Heading B1D. [Also in Division D1] Porous fabrics for filter media, such as endless dewatering belts in paper making machines, as formed from yarns of polymeric monofilaments of non-circular cross-section, individual monofilaments and groups of monofilaments forming yarns being separately twisted. The fabrics may be woven or yarns may be bonded without weaving but using thermofusion, solvent setting or adhesion techniques. Preferred materials are cellulose nitrate, cellulose acetate, cellulose acetate/butyrate, polystyrene, polyethylene, polycarbonates, polypropylene, polymers of vinyl esters, polyvinyl chloride, polyvinylidene chloride, copolymers of styrene and acrylonitrile, copolymers of styrene and butadiene polytetrafluoroethylene, polychlorotrifluoroethylene, nylon, polymethyl methacrylate, and ethyl-cellulose. Filaments may have metallic wires embedded in them or may be impregnated with between about 20-40% by weight of a filler material such as glass flakes comprised of borosilicate.
Patent GB-1054364-A (GB)
IPC: F16D65/60
Abstract: 1,054,364. Brakes. CLAYTON DEWANDRE CO. Ltd. March 19, 1964 [April 4, 1963], No. 13345/63. Heading F2E. A slack adjuster for cam operated brakes, particularly internal shoe drum brakes, is of the type wherein a body member 1 formed as a brake actuating lever is rotatable on a camshaft to which is keyed a worm-wheel 3, and a worm 4 is journalled within the body 1 and co-operates with the worm-wheel to maintain the body in a predetermined position relative to the shaft, adjustable by rotation of the worm 4, the adjuster being characterized by a unidirectional clutch one part, e.g. a ratchet wheel 11, of which has a direct driving connection with the worm and the other part, e.g. a pawl 12, is mounted on a carrier 13 rotatable relating to the body and formed as a lever 15 the outer end of which is fixed relative to the brake, e.g. by being connected to a point on the vehicle chassis frame 17 via a rod 16. The driving connection between the ratchet wheel 11 and the worm 4 is via another worm 8 engaging a wormwheel 7 on shaft 6 of worm 4. In a modification (Fig. 3, not shown) manual adjustment is facilitated by a modified pawl 12a having a tail 12b operated manually through a plunger 18.
Patent GB-1054534-A (GB)
IPC: C07D333/48
Abstract: 1,054,534. Sulpholanes and their manufacture and purification. SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ N.V. June 21. 1965. No. 26046/65. Heading C2C. A sulpholane is purified by subjecting it to an extractive treatment with an aliphatic hydrocarbon or mixture of aliphatic hydrocarbons, the term " aliphatic hydrocarbons " being used to include cycloaliphatic hydrocarbons. The hydrocarbons are preferably those which are at least partially immiscible with the sulpholane and which can be separated from the latter by distillation and one or more other compounds may also be present but the presence of aromatic hydrocarbons should be avoided. Specified solvents are cyclohexane and petroleum ether (B.P. 60-80‹ C.). The process is preferably carried out within the temperature range 20- 60‹ C. and in at least two stages. The purified sulpholane may be used as a solvent for the manufacture of a sulpholane, by reacting a 1: 3 alkadiene with sulphur dioxide to produce a sulpholene and catalytically hydrogenating the sulpholene. both steps of the process being carried out in the presence of the purified sulpholane. The hydrogenation may be carried out, in the case of 3-sulpholene, in the presence of Raney nickel and at 30‹ C. under a hydrogen pressure of 500 p.s.i.g. in a stirred autoclave.
Patent GB-1226335-A (GB)
IPC: D04B11/06
Filed: 1967-07-25
Abstract: 1,226,335. Knitting-machines. WILLIAM COTTON Ltd. 22 July, 1968 [25 July, 1967], No. 34109/67. Heading D1C. [Also in Division G3] Normal selvedge fashioning control is achieved on a straight-bar on flat bed knitting machine by the provision of a main punched chart programming means and in addition pattern control by means of patterning loop transfer points is achieved by a separate auxiliary punched chart programming means. By the provision of two separate punched chart programming means, fashioning and patterning can be achieved in the same or separate courses and when it is desired to alter the pattern being produced without altering the fashioning sequence there is no need to disturb the fashioning punched chart programming means but merely to replace the punched chart for the pattern programming means. The main programming means for the fashioning control which is automoatically controlled as described in Specification 960816 includes provision for course counting which can be interrupted in the event of patterning occurring in any particular course. The main punched chart controls the auxiliary punched chart in so far as it initiates operation of the latter and on completion of the patterning sequence the auxiliary punched chart programming means is stopped by a signal from itself. The fashioning mechanism includes adjustable lead screw racking mechanism which is rendered ineffective during continuous patterning in a particular course. If fashioning is to be effected in the same course as patterning then the fashioning motion is performed first and the patterning sequences are performed afterwards. Although the control described is basically of electric type the control can be alternatively effected by mechanical means including hydraulic or pneumatic means.
Patent GB-1226525-A (GB)
IPC: F28F27/02
Filed: 1969-01-22
Abstract: 1,226,525. Tubular heat exchangers. FOSTER WHEELER JOHN BROWN BOILERS Ltd. 12 Jan., 1970. [22 Jan., 1969], No. 3666/69. Heading F4S. A composite tube plate 16, for use in a shell and tube heat exchanger (see Fig. 2) having straight or U-tubes, comprises two spaced-apart plates 18 and 20 through which at least some of the tubes 14 or extensions thereof pass and are sealingly fixed. As shown, stub tubes 24, welded to the tubes 14 at 30 and to the plates 18, 20 at 28, are closed by end caps 32. Apertures 25 provide fluid communication between the tubes and the space 40 between the plates, which space 40 is closed by an end member 22 to define a header chamber. In a simplified embodiment (Fig. 3, not shown), the stub tubes are omitted and the heat exchange tubes (76) themselves are passed through bores in the plates (72, 74) and are fixed to each plate by expanding the tube into recesses (78) formed in the walls of the bores (77). Caps (80) are welded to the ends of the tubes.
Patent GB-1229031-A (GB)
IPC: B63B9/00
Filed: 1968-04-03
Abstract: 1,229,031. Joining floating hull sections. MITSUBISHI JUKOGYO K.K. 3 April, 1968 [28 April, 1967], No. 16107/68. Heading B7S. In a method of joining together two parts 1, 2 of the hull of a ship, when the parts are floating, an edge of part 1 is arranged adjacent to and in alignment with an edge of part 2, the two parts are secured by fitting unit 9 a fixed distance apart in a manner permitting transverse and vertical relative movements between the parts and after more precise alignments of the hull parts they are drawn together and welded along the adjacent edges.
Patent GB-1230240-A (GB)
IPC: C09D11/10
Filed: 1969-12-30
Abstract: 1,230,240. Phenolic resins. SOC. ITALIANA RESINE S.p.A. 30 Dec., 1969 [31 Dec., 1968], No. 63367/69. Heading C3R. A phenolic resin is prepared by condensing pcumyl phenol, formaldehyde and rosin at 130-270 C. in the presence of a salt of Ca, Mg, Mn or Zn with an acid having a dissociation constant of less than 1À8 Î 10<SP>-5</SP>, the molar ratio of aldehyde to phenol being between 2.5 and 4 to 1 and the weight of rosin being 1À5 to 2 times that of phenol. The formaldehyde may be paraformaldehyde, and the salt may be ZnCO 3 . A polyol, e.g. glycerol, sorbitol or pentaerythritol may also be present.
Patent GB-1231506-A (GB)
IPC: A61L15/28
Filed: 1968-11-13
Abstract: 1,231,506. Solubilized alginate. WALLACE, CAMERON & CO. Ltd. 11 Sept., 1969 [13 Nov., 1968], No. 53725/68. Heading C3U. A solubilized calcium-containing alginic material is produced by a method comprising acidifying calcium alginate with a calculated quantity of acid sufficient to remove a desired amount of calcium, and reacting the acidified calcium alginate with a base, such as sodium or potassium hydroxide, whereby the calcium removed by the acidification is replaced by a solubilizing cation. The calcium alginate may be bleached prior to acidification, e.g. with sodium hypochlorite, and is suitably in the form of a gauze. Excess base may be removed from the solubilized alginate using a weak acid.
Patent GB-1232163-A (GB)
IPC: B67D7/38
Filed: 1969-06-30
Abstract: 1,232,163. Fuel supply hose reels. TOKICO Ltd. 30 June, 1969 [2 July, 1968], No. 32881/69. Heading B8M. [Also in Division A4] A hose reel used in a fuel-supplying installation has a reel as shown, fuel being supplied from stationary conduit 15 to rotatable axle 41. Holes in this axle allow fuel to pass into the rotatable portion of the reel, and into hose 25. Air motor 40 rotates axle 41 and the reel to disperse hose. At the end of this movement, a further length of hose may be pulled off the reel against the force of spring 43, rotating the reel about axle 41. When the hose is released, the spring rotates the reel to draw up the further length. The air motor 40 is then used to rewind the hose. The whole arrangement is attached to ceiling or beam 12.
Patent GB-1233671-A (GB)
IPC: F03B3/14
Filed: 1969-02-03
Abstract: 1,233,671. Hydraulic turbines. LENINGRADSKY DVAZHDY ORDENA LENINA METALLICHESKY ZAVOD IMENI XXII SIEZDA KPSS. Feb.3, 1969, No.5616/69. Headings F1C and F1T. The invention relates to a hydraulic turbine or pump having angularly adjustable runner vanes and to feedback means by which movement of the servomotor controlling the angular position of the vanes is fed back to the turbine governor. The turbine runner comprises a fluid servomotor which controls the angular position of the runner vanes 6, fluid being supplied to the servomotor which is of the rotary vane kind through ducts 10, 11 from a valve 4 which is controlled by governor 2 which is operated by an A.C. generator 7. The outer duct or sleeve 10 is responsive to angular movement of the servomotor. A cylindrical member 12 is mounted on the sleeve 10 by means of a key connection 13 so that the member 12 rotates with the sleeve but may move axially relatively thereto. A further sleeve member 14 is mounted on the member 12 by means of bearings 15, the sleeve 14 being constrained against rotational movement but moving axially with the member 12. The sleeve 14 is connected to the governor 2 by means of a flexible cable 17, the cable being maintained in tension whereby the member 12 is urged upwardly. The member 12 is formed with a cam face 21 against which engage rollers 20 mounted on shafts 22 which are secured in brackets 23 which in turn are mounted on a member 25 which is secured to the turbine runner shaft 8. Thus as the servomotor moves so does the sleeve 10 and also the cylindrical member 12; because of the engagement of the cam face 21 with the rollers 22, the rotational movement of the member 12 causes axial movement thereof which movement is fed back to the governor through the flexible cable 17. The shafts 22 have an eccentric portion on which the rollers 20 are mounted so that the position of the shafts may be adjusted and then secured.
Patent GB-1234107-A (GB)
IPC: F16K5/02
Filed: 1968-05-31
Abstract: 1,234,107. Valves. ROBERTSHAW CONTROLS CO. 31 May, 1968 [2 June, 1967], No. 26298/68. Heading F2V. [Also in Division F4] A valve device for controlling the supply of fuel gas to a main burner 18, comprises a manually operated valve member 32 which has a flow chamber 37 with an inlet port 38 cooperating with a port 12 in the valve housing and an outlet port 44 regulated by a second valve member 64 in response to the outlet pressure. This pressure is communicated through the hollow valve member 64 to a chamber 82 between a balancing diaphragm 70 and an actuating diaphragm 84 which, as shown, is adjustably spring loaded. Gas to a pilot burner 24 in pilot lighting and full flow positions of the conical plug type manual valve 32 is permitted through respective ports 42, 39. The device includes a safety cut-off valve (not shown) in the valve housing inlet, controlled by a thermocouple 26. The device also includes a conventional thermally-actuated valve (48), Fig. 2, upstream of the main outlet (14). This may be actuated by a rod and tube thermostat (60) inserted in a hot water tank. In a modification, the spring loading of the actuating diaphragm 84 is replaced by a fluid pressure loading in accordance with a regulated pressure supplied to the pilot burner. The pilot pressure in this case is regulated by a spring-loaded diaphragm valve (110), Fig. 3 (not shown) which is responsive to the downstream pressure and communicates on the upstream side with the ports 39, 42. The valve plug 32 is retained by a spring plate.
Patent GB-1250096-A (GB)
IPC: H04N11/20
Filed: 1969-04-09
Abstract: 1,250,096. Television. BRITISH BROADCASTING CORP. 13 Feb., 1970 [9 April 1969], No. 18198/69. Heading H4F. Before mixing PAL or NTSC signals e.g. from a remote source, the chrominance information must be provided on a subcarrier sychronized in phase and frequency with a master subcarrier of frequency W R . This is accomplished without first demodulating the chrominance signal cos w 0 t from a filter 12, by passing the signal through a 90 degree phase change network 17, multiplying 16, 18, the chrominance signal and the output of the network 17 respectively by signals sin w D t and cos w D t from a generator 20 and adding 21, 13, the multiplied signals to the luminance signal Y from a filter 11, whereupon Y + sin w D t. cos w 0 t + cos w D t sin w 0 t = Y + cos w R t, where w R =(w D +w 0 ). In the generator 20, Fig. 3 (not shown), signals cos w 0 t and sin w 0 t are derived from an oscillator locked to the colour bursts of the input signal and are composed in phase with the master subcarrier signal cos w R t to develop the signals cos w D t and sin w D t. In a modification, Fig. 2 (not shown), the generator produces a signal (sin w D t - 1) rather than sin w D t, and the entire input signal Y + cos w 0 t is added to the outputs of the multipliers 16, 18 to give an output signal Y + sin w R t.