Patent SG-11201408093P-A (SG)
Title: Amides of 2-amino-4-arylthiazole compounds and their salts
Inventor: KADAM SURESH MAHADEV
IPC: C07D495/04
Filed: 2013-06-08
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 December 2013 (12.12.2013) WIPOIPCT (10) International Publication Number WO 2013/183035 A2 (51) International Patent Classification: C07D 495/04 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/IB2013/054703 8 June 2013 (08.06.2013) English English (30) Priority Data: 1687/MUM/2012 8 June 2012 (08.06.2012) IN 61/665,282 27 June 2012 (27.06.2012) US 3519/MUM/2012 13 December 2012 (13.12.2012) IN 61/748,016 31 December 2012 (31.12.2012) US (71) Applicant: GLENMARK PHARMACEUTICALS S.A. [CH/CH]; Chemin de la combeta 5, CH-2300 la Chaux-de- fonds (CH). (72) Inventors: KADAM, Suresh Mahadev; 1501-B Wing, Royale Bldg, Neelkanth Palms, Kapurbawadi, Majiwade, Maharashtra, Thane (West) 400607 (IN). THOMAS, Ab­ (84) raham; Flat No. 5, 11th Floor, Building No. A-6, Millen­ nium Towers, Sector 9, Sanpada, Maharashtra, Navi Mum- bai 400705 (IN). SINHA, Sukumar; Prajapati Lawns, Plot No-7, Flat No-A-701, Sector-6, Kharghar, Maharashtra, Navi Mumbai 410210 (IN). KUMAR, Sukeerthi; 404A, Vardhaman Enclave, Plot No. 3, Sector-20, Airoli, Maha­ rashtra, Navi Mumbai 400708 (IN). KANSAGRA, Bipin Parsottam; 10/704, Fam C.H.S., Sector -11, Koparkhair- ane, Maharashtra, Navi Mumbai 400709 (IN) GAVHANE, Sachin; 501/13 Godavari, River Wood Park CHS, Kalyan -Shil Road, Deasigaon, Khidakali, Dombivli (East), Dist - Thane, Maharashtra Thane 4210204 (IN) KHANDAGALE, Sandeep Bandu; At - Gokhalewadi Post - Subhashwadi, Tal Shrirampur, - Dist Ahmednagar - Maharashtra Shrirampur 413709 (IN). PAWASE, Shailesh; 64, Rammandir CHS, LBS Marg, Mulund Checknaka, Mulund (W), Maharashtra, Mumbai 400080 (IN). PATIL, Jayant Prakashrao; A/P -Nimgaon Madh, Tal -Yeola, Dist-Nasik, Maharashtra, Nasik 423401 (IN). BHADANE, Shailendra; C/o. N. B. Bhadane, # 4/5, Om nivas, Opp. Telephone exchange office, Near old water tank, Balaji nagar, A/P Tal - Chopda, Dist Jalgaon, - Maha­ rashtra Jalgaon 425107 (IN). MISHRA, Bhavna; Flat No - 401, B-wing, Kanchan Changa Building, Sector-llB, Ko- parkhairane, Mahrashtra, Navi Mumbai 400709 (IN). DWIVEDI, Rajesh; Flat No. 4, Blue Heaven, Plot No. 131, Sector-12, Vashi, Maharashtra, Navi Mumbai 400703 (IN). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — of inventorship (Rule 4.17(iv)) Published: — without international search report and to be republished upon receipt of that report (Rule 48.2(g)) Hr,C.. O^N I > S o s- N^N H (H) = (54) Title: AMIDES OF 2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AND THEIR SALTS CJ m o m oo T-H rn i-H (57) Abstract: The present disclosure directed is to salts of N-{4-[2,4-difluoro-3- (trifluoromethyl)phenyl]-l,3-thiazol-2-yl}-2-(l,3- © dimethyl-2,4-dioxo-l,2,3,4- tetrahydrothieno[2,3- d]pyrimidin-5-yl)acetamide and process for the preparation thereof (formula II).. N M F CF. CH,