baber/WOPTO huggingface dataset:
Patent WO-2020214885-A1 (WO)
Inventor: ZHUANG XIAOWEI
IPC: C12N9/22
Filed: 2020-04-17
Abstract: The present invention generally relates to imaging cells, for example, to determine phenotypes and/or genotypes in populations of cells, e.g., to build genotype-phenotype corresponse for high-throughput screening. In some cases, the cells may be manipulated, e.g., using CRISPR or other techniques. In certain embodiments, nucleic acids may be introduced to the cell, e.g., using a lentivirus. The nucleic acids may contain a guide portion comprising a DNA or RNA recognition sequence, a reporter portion, and an identification portion comprising one or more read sequences. The guide portion may be used to alter the phenotype of the cells, e.g., using a sequence, e.g., an sgRNA sequence, that can be targeted using CRISPR or other techniques, and in some cases, the phenotype of the cells may be determined using various imaging approaches. The identification portion may be determined using MERFISH or other suitable techniques. In addition, in some cases, association or colocalization between determination of the reporter and the read sequences may substantially improve decoding accuracy, e.g., due to lowered misidentification of background signals. Other aspects are generally directed to compositions or devices for use in such methods, kits for use in such methods, or the like.
Patent WO-2020219419-A1 (WO)
Title: Multimeric pan–selectin antagonists
Inventor: MAGNANI JOHN L
IPC: A61K31/7036
Filed: 2020-04-21
Abstract: Compounds, compositions, and methods for modulating in vitro and in vivo processes mediated by se lectin binding are described herein. For example, multimeric selectin modulators and their use are described, wherein the multimeric selectin modulators comprise a glycomimetic linked to a member of a class of compounds termed BASAs (Benzyl Amino Sulfonic Acids) or a member of a class of compounds termed BACAs (Benzyl Amino Carboxylic Acids).
Patent WO-2020247116-A1 (WO)
Inventor: MORRIS JOHN RICHARD
IPC: H04R5/033
Filed: 2020-04-29
Abstract: A headphone device having a listening configuration and a storage configuration. In the listening configuration, the headphone device is configured to provide an ergonomic fit for a user when the headphone device is worn on the user's head with earcups oriented over the user's ears. In the storage configuration, the headphone device is configured to provide an ergonomic fit for the user when the headphone device is worn around the user's neck.
Patent WO-2020236729-A1 (WO)
Inventor: OAKLEY JONATHAN
IPC: A61B5/00
Filed: 2020-05-18
Abstract: La présente invention concerne un procédé d'automatisation de la segmentation de fibres nerveuses de la cornée sur la base d'une approche de la segmentation par apprentissage profond. Les procédés de l'invention offrent des résultats plus robustes en utilisant la puissance de procédés d'apprentissage supervisés conjointement aux techniques de pré-traitement et de post-traitement documentées.
Patent WO-2020236759-A1 (WO)
Inventor: COLLINS JOHN-MARK
IPC: A63F13/00
Filed: 2020-05-18
Abstract: A spatial entertainment platform that be used for interconnected gaming in physical environments without requiring a user to wear goggles or other sensors. Optionally, users in different physical locations can interact in real-time in a single virtual environment. The system preferably uses one or more projectors and a plurality of sensors to track a user and map them to a virtual environment. The platform can be used not only for gaming but also for educational training, teambuilding, healthcare and for other applications.
Patent WO-2020243701-A1 (WO)
Title: Systèmes et procédés d'apprentissage machine d'attributs de voix
Inventor: EDWARDS ERIK
IPC: A61K35/741
Filed: 2020-06-01
Abstract: L'invention concerne des systèmes et des procédés d'apprentissage machine d'attributs de voix et autres. Le système reçoit des données d'entrée, isole des sons prédéterminés à partir de la parole isolée d'un locuteur d'intérêt, résume les caractéristiques pour générer des variables qui décrivent le locuteur, et génère un modèle prédictif pour détecter une caractéristique souhaitée d'une personne. L'invention concerne également des systèmes et des procédés pour détecter un ou plusieurs attributs d'un locuteur sur la base d'une analyse d'échantillons audio ou d'autres types d'informations stockées numériquement (par exemple, des vidéos, des photos, etc.).
Patent WO-2020247611-A1 (WO)
Inventor: HICKEY KYLE
IPC: B60S5/06
Filed: 2020-06-04
Abstract: A mounting and dismounting system for replaceable power sources is disclosed. The mounting and dismounting system is integrated into a vehicle. The vehicle may be an electric vehicle and the replaceable power source may include at least one battery. The mounting and dismounting system includes a lift rack assembly that engages shafts on the replaceable power source to raise and lower the replaceable power source. The mounting and dismounting system also includes a set of retaining members to help keep the shafts in place. The lift rack assembly includes rack members that move in a substantially vertical direction to limit swinging and tilting.
Patent WO-2020257018-A1 (WO)
Inventor: THAI HIEN
IPC: H04W12/12
Filed: 2020-06-10
Abstract: In one example, a firewall obtains a first network packet that indicates a first mobile country code of a mobile subscriber at a first time and a first mobile network code of the mobile subscriber at the first time. The firewall obtains a second network packet that indicates a second mobile country code of the mobile subscriber at a second time and a second mobile network code of the mobile subscriber at the second time. The firewall determines whether the first mobile country code is different from the second mobile country code or the first mobile network code is different from the second mobile network code. If so, the firewall determines whether a difference between the second time and the first time is less than a threshold difference. If so, the firewall associates the second network packet with a potential security threat.
Patent WO-2021011593-A1 (WO)
Inventor: ROTH MARK
IPC: G06K7/00
Filed: 2020-07-15
Abstract: A method for recovering missed RFID tagged items in an RFID tunnel environment is disclosed. The method comprises using a dynamic RFID tunnel system comprised of a first RFID tunnel and a second RFID tunnel to inventory one or more containers of items having RFID tags. A first RFID read is performed in the first RFID tunnel and compared to expected inventory stored in a database. If the comparison does not match, a second RFID read is performed in a subsequent RFID tunnel at a higher RFID read power and by moving the containers slower than the speed of movement of the containers into the first RFID tunnel. If a comparison of the second read to the expected containers' inventory still does not match, the containers may be recirculated through the tunnel system or may be diverted to an exceptions audit depending on how the system is configured.
Patent WO-2021026004-A1 (WO)
Inventor: HAYTER GARY A
IPC: A61B5/022
Filed: 2020-07-31
Abstract: Systems, devices and methods are provided for determining a medication dose for a patient or user. The dose determination can account for recent and/or historical analyte levels of the patient or user. The dose determination can also take into account other information about the patient or user, such as physiological information, dietary information, activity, and/or behavior. Many different dose determination embodiments are set forth, pertaining to a wide array of different aspects of the system or environment in which the embodiments can be implemented.
Patent WO-2021026035-A1 (WO)
Inventor: SEJOUBSARI REIHANEH
IPC: B32B7/12
Filed: 2020-07-31
Abstract: Methods are disclosed to prepare permanent materials that can be coated onto microelectronic substrates or used for other structural or optical applications. The materials are thermally stable to at least about 300°C, curable using a photo or thermal process, exhibit good chemical resistance (including during metal passivation), and have a lifespan of at least about 5 years, preferably at least about 10 years, in the final device. Advantageously, these materials can also be bonded at room temperature. The materials exhibit no movement or squeeze-out after bonding and adhere to a variety of substrate types.
Patent WO-2021026155-A1 (WO)
Title: Cellules cibles artificielles pour la cytotoxicité de car in-vitro et la validation d'adcc
Inventor: KLINGEMANN HANS G
IPC: G01N33/50
Filed: 2020-08-04
Abstract: L'invention concerne des lignées cellulaires cibles artificielles présentant une distinction améliorée entre l'élimination d'arrière-plan et l'élimination médiée par ADCC et/ou CAR. Dans certains modes de réalisation, les cellules artificielles sont des cellules SUP-B15 recombinées exprimant des antigènes cibles étant reconnus par un CAR, et/ou un dispositif de mise en prise bispécifique, ou un anticorps thérapeutique.
Patent WO-2021030595-A1 (WO)
Inventor: TOOHER J PATRICK
IPC: H04L5/00
Filed: 2020-08-13
Abstract: A method for use in a wireless transmit/receive unit is disclosed. The method may comprise: obtaining a transmission occasion for a channel state information reference signal (CSI-RS); obtaining at least one conditional transmission occasion for the CSI-RS; and determining whether the CSI-RS is transmitted in the transmission occasion, wherein on a condition that the CSI-RS is not transmitted in the transmission occasion, detecting if the CSI-RS is transmitted in one of the at least one conditional transmission occasion.
Patent WO-2021030807-A1 (WO)
Inventor: ELLIOTT STEVE
IPC: A61B90/90
Filed: 2020-08-17
Abstract: A radio frequency identification (RFID) tag insertion cartridge configured for use in implanting a flexible RFID tag into a small animal using a needle-retraction implant tool. In embodiments, the cartridge includes a cartridge housing (110) and a bevel cap (120). In embodiments, the cartridge housing is configured to receive a carriage portion (114) inserted into a first end (124) of the cartridge housing with a retractable needle (118) extended out of a second end (126) of the carriage portion to present the retractable needle (118) in an extended position with the RFID tag carried within the retractable needle. In embodiments, the bevel cap has a proximal portion with a mating feature (200) configured to mate with the cartridge housing and one or more needle capture elements (204) configured to selectively couple to the needle in the extended position in a side-mountable manner without a direct axial force being exerted on the needle.
Patent WO-2021035032-A1 (WO)
Title: Delivery and retrieval devices and methods for side-deliverable transcatheter prosthetic valves
Inventor: VIDLUND ROBERT
IPC: A61F2/92
Filed: 2020-08-20
Abstract: A delivery system for side-delivery of a prosthetic valve includes a compression device defining a lumen having a first perimeter at a proximal end that is larger than a second perimeter of the lumen at a distal end. A loading device is coupleable to the compression device and defines a lumen having substantially the second perimeter. A distal end of the loading device includes a first gate that is movable between an open state and a closed state to at least partially occlude the lumen of the loading device. A delivery device defines a lumen having substantially the second perimeter. A proximal end of the delivery device is coupleable to the distal end of the loading device and includes a second gate movable between an open state and a closed state to at least partially occlude the lumen of the delivery device.
Patent WO-2021050620-A1 (WO)
Title: Thermoplastic polyurethane composition
Inventor: SOLOUKI BONAB VAHAB
IPC: C08G18/48
Filed: 2020-09-10
Abstract: The invention relates to a thermoplastic polyurethane material that has high flex modulus, low density, and is capable of withstanding repeated cyclic deformation. The thermoplastic polyurethane composition is formed from the reaction product of a polyol component, which includes a blend of a polyether polyol, such as poly(tetramethylene ether glycol), and polybutadiene diol, a diisocyanate component, and a chain extender component.
Patent WO-2022060354-A1 (WO)
Title: Adaptive active noise control system with hearing assistance mechanism
Inventor: SUN GUOHUA
IPC: H04R1/10
Filed: 2020-09-16
Abstract: The present disclosure provides systems and method for adjusting the audio output of a wearable device based on an audio gain profile of a user. The wearable device may receive an audiogram indicating one or more frequency ranges associated with hearing loss. The wearable device may determine the audio gain profile based on the audiogram. The wearable device may use one or more adjustment modules to determine a gain to apply to the audio output based on the audio gain profile. The adjustment modules may include an active noise control module, a hearing assistance module, and a transparency control module. The wearable device may determine the amount of gain to apply using a least mean square algorithm and/or a machine learning model.
Patent WO-2021055447-A1 (WO)
Title: Compression fit grooved spacer
Inventor: BUCHANAN RONALD
IPC: E06B3/663
Filed: 2020-09-16
Abstract: A spacer supports first and second panes of an insulating unit wherein the spacer also compressively supports a third inner pane between the first and second panes. The spacer defines a channel that receives the outer perimeter edge of the third pane. The spacer on either side of a channel neck is deformed when the third pane is inserted into the channel. The resiliency of the spacer material causes the spacer material on both sides of the channel neck to compressively engage the third pane of glass. The spacer thus holds the inner spacer without the need for an adhesive disposed in the channel. This configuration closes the channel against the pane preventing the internal surface of the channel from being viewed which provides a desirable appearance to the inner portion of the insulating glass unit.
Patent WO-2021061504-A1 (WO)
Inventor: CHMIELOWSKI REBECCA
IPC: C07K16/36
Filed: 2020-09-18
Abstract: L'invention concerne des procédés de séparation de lipases de cellules hôtes d'une protéine de production lors de processus chromatographiques et des procédés d'amélioration de la stabilité du polysorbate-80 dans une formulation de protéines de production en séparant les lipases de cellules hôtes de la protéine de production à l'aide de processus chromatographiques. L'invention concerne également des compositions comprenant des anticorps ou leurs fragments de liaison à l'antigène qui se lient à l'antigène 4 associé aux lymphocytes T cytotoxiques (CTLA4). Selon un autre aspect, de telles compositions comprennent en outre un niveau réduit de protéines de cellules hôtes et/ou un niveau accru de stabilité du polysorbate-80 (PS-80).
Patent WO-2021055729-A1 (WO)
Title: Improved thermostable viral reverse transcriptase
Inventor: CHUNG SUHMAN
IPC: C12N9/12
Filed: 2020-09-18
Abstract: The present invention provides novel engineered reverse transcriptase enzymes that afford beneficial improvements in thermal stability, processivity, cDNA yields and elimination of secondary enzymatic activity. The present invention also provides methods for amplifying template nucleic acids using such reverse transcriptase enzymes. This invention addresses deficiencies in the current state of the art reverse transcriptase enzymes in RNA detection and analysis including deficiencies in detection sensitivity, specificity, side enzyme activities, enzyme stability and synthesis capacity, especially when using template nucleic acids ranging in length, secondary structure and nucleotide content.
Patent WO-2021055912-A1 (WO)
Title: Composite rotor for flywheel energy storage system
Inventor: LAZAREWICZ MATTHEW L
IPC: F16F15/305
Filed: 2020-09-20
Abstract: Composite rotors provided herein include a rotor body extending along a longitudinal axis including a first component extending longitudinally along at least a portion of the rotor body and a second component extending longitudinally along at least a portion of the rotor body, at least a portion of the second component disposed concentrically around the first component, wherein the first component and the second component together define an internal region, wherein a radial thickness of the first component and a radial thickness of the second component vary along the longitudinal axis. The composite rotor also includes at least one magnet disposed on an inner surface of at least one of the first component or the second component within the internal region.
Patent WO-2021061625-A1 (WO)
Title: Quantized inputs for machine learning models
Inventor: LAZOVICH TOMO
IPC: G06V10/774
Filed: 2020-09-22
Abstract: Methods and apparatus for pre-processing first data for use with a trained machine learning model. In some embodiments, the method may comprise accessing the first data, wherein the first data has a first precision; generating, based on at least a first portion of the first data, second data having a second precision lower than the first precision; and providing the second data as input to the trained machine learning model to generate model output.
Patent WO-2021067202-A1 (WO)
Title: Controlling a process for inspection of a specimen
Inventor: BRAUER BJORN
IPC: G01N21/88
Filed: 2020-09-29
Abstract: Methods and systems for controlling a process for inspection of a specimen are provided. One system includes one or more computer subsystems configured for determining a statistical characteristic of difference images generated for multiple instances of a care area on a specimen and determining variation in the statistical characteristic compared to a statistical characteristic of difference images generated for multiple instances of the care area on one or more other specimens. In addition, the one or more computer subsystems are configured for determining one or more changes to one or more parameters used for detecting defects in the care area on the specimen based on the variation.
Patent WO-2021067500-A1 (WO)
Inventor: IVES CRAIG E
IPC: G02B6/136
Filed: 2020-09-30
Abstract: A method of fabricating a photonic device includes in part, forming a multitude of metal and dielectric layers over a semiconductor substrate to form a structure. The metal layers form a continuous metal trace that characterize an etch channel. At least one of the metal layers extends towards an exterior surface of the structure such that when the structure is exposed to a metal etch, the metal etch removes the metal from the exterior surface of the structure and flows through the etch channel to fully etch the metal layers. The metal etch leaves behind a dielectric structure characterizing a photonic device. The photonic device may be a suspended rib waveguide, a suspended channel waveguide, a grating coupler, an interlayer coupler, a photodetector, a phase modulator, an edge coupler, and the like. A photonics system may include one or more of such devices.
Patent WO-2021072259-A1 (WO)
Title: Reduced volume formulations including amino acid entities
Inventor: LEGASSIE JASON
IPC: A23J3/00
Filed: 2020-10-09
Abstract: This disclosure provides compositions and methods for improving the dispersion of a hydrophobic amino acid entity in an aqueous suspension. This disclosure further provides compositions and methods for improving the stability of N-acetylcysteine in the presence of acetyl acceptors, e.g., carnitine.
Patent WO-2021072315-A1 (WO)
Title: Adjustable flow glaucoma shunts and associated systems and methods
Inventor: LILLY RICHARD
IPC: A61L27/06
Filed: 2020-10-09
Abstract: The present technology is directed to adjustable flow glaucoma shunts and methods for making and using such devices. In many of the embodiments described herein, the shunts include a generally flat frame. The frame can include an elongated portion having a lumen extending therethrough and a bladder portion defining an interior chamber that is in fluid communication with the lumen. When implanted in a patient's eye, aqueous can drain from the anterior chamber to a target outflow location via the lumen and interior chamber. In some embodiments, the shunts include a flow control assembly positioned within the interior chamber of the bladder portion to control the flow of aqueous through the lumen.
Patent WO-2021081357-A1 (WO)
Title: Treatment of epileptic conditions with gabaa receptor modulators
Inventor: HUBBS JED
IPC: C07D249/16
Filed: 2020-10-23
Abstract: Disclosed herein are GABAA receptor modulators and compositions comprising GABAA receptor modulators for treatment of epileptic conditions. Also disclosed herein are methods of treating epileptic conditions in a subject by administering a GABAA receptor modulators or composition as described herein.
Patent WO-2021097091-A1 (WO)
Title: Processes and systems for producing ammonia products and/or calcium carbonate products
Inventor: SEVERSON ANNMARIE D
IPC: C01C1/02
Filed: 2020-11-12
Abstract: Systems and processes for producing ammonia products and/or calcium carbonate products, including but not limited to an organic high sulfur liquid ammonium product and an organic calcium carbonate product from an effluent derived from one or more organic feedstocks. Solids are removed from an organic feedstock that contains a nitrogen compound to produce an organic liquid effluent that contains ammonium and/or ammonia. Ammonia is stripped and concentrated from the organic liquid effluent to produce a gaseous mixture that contains ammonia, and the gaseous mixture is cooled to produce a condensed aqueous ammoniacal nitrogen solution of aqueous ammonia, ammonium bicarbonate, and/or ammonium carbonate. The condensed aqueous ammoniacal nitrogen solution is then contacted with a stabilizing agent to cause a reaction therebetween to produce at least a stabilized ammoniacal nitrogen product.
Patent WO-2021141687-A1 (WO)
Title: Working-time-based routing for customer support
Inventor: CALLEWAERT FRANCOIS
IPC: G06Q10/00
Filed: 2020-11-20
Abstract: Techniques performed by a data processing system for matching a customer service ambassador (CSA) with a customer include receiving a service request for technical assistance from the customer, analyzing estimated working hours information for the customer and estimated working hours information for each of the plurality of CSAs to produce a compatibility score for each CSA, the compatibility score for a respective one of the CSAs providing an indication of how closely the working hours of the customer and of the respective one of the CSAs align, reordering an available CSA queue identifying the plurality of CSAs based on the compatibility scores of each of the CSAs, and selecting a CSA from the queue to provide technical assistance to the customer.
Patent WO-2021113768-A1 (WO)
Title: Furnace system and method of use
Inventor: CONNOR STEPHEN T
IPC: C04B35/64
Filed: 2020-12-04
Abstract: A sintering furnace can include an outer shell defining an internal volume a reactive agent inlet configured to introduce a reactive agent into the internal volume; an insulation chamber within the outer shell; and a retort configured to retain an object. A method of operating a sintering furnace can include sintering a part precursor within a retort arranged within a chamber, wherein the chamber defines an intermediate volume between the retort and the chamber, wherein a sintering byproduct is oxidized within the intermediate volume.
Patent WO-2021146085-A1 (WO)
Title: Privilege auto platform
Inventor: CASE ANDY
IPC: A63F13/30
Filed: 2021-01-06
Abstract: Enabling control of authenticated applications and websites from other applications and websites within an auto entertainment service, including: implementing controls of the auto entertainment service within a privilege auto platform with a defined structure that enables a controller to issue a command; constructing calls appropriate to execute the command; routing playback controls through the privilege auto platform; issuing the command to the privilege auto platform with a content ID; and receiving the command and making the calls for content and digital rights management to execute the command.