Patent SG-11201408037S-A (SG)
Title: Humanized anti-trka antibodies with amino acid substitutions
Inventor: BLEIN STANISLAS
IPC: A61P29/00
Filed: 2013-06-07
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 December 2013 (12.12.2013) WIPOIPCT (10) International Publication Number WO 2013/183032 A3 (51) International Patent Classification: C07K16/28 (2006.01) A61K39/395 (2006.01) A61P 29/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/IB2013/054688 7 June 2013 (07.06.2013) English English (30) Priority Data: 61/657,184 8 June 2012 (08.06.2012) US (71) Applicant: GLENMARK PHARMACEUTICALS S.A. [CH/CH]; Chemin de la combeta 5, CH-2300 la Chaux-de- Fonds (CH). (72) Inventors: BLEIN, Stanislas; Chemin de la Combeta 5, CH-2300 La Chaux-de-Fonds (CH). OLLIER, Romain; Chemin de la Combeta, CH-2300 La Chaux-de-Fonds (CH). SKEGRO, Darko; Chemin de la Combeta 5, CH- 2300 La Chaux-de-Fonds (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a)) (88) Date of publication of the international search report: 20 February 2014 CJ m o m oo i-H o CJ (54) Title: HUMANIZED ANTI-TRKA ANTIBODIES WITH AMINO ACID SUBSTITUTIONS (57) Abstract: The present invention relates to antibodies directed against TrkA receptor and their uses, including humanized an- ti-TrkA antibodies. More specifically, the present invention relates to humanized anti-TrkA antibodies with enhanced inhibitory properties comprising heavy chain variable a region, a light chain variable region, human a light chain constant region and a variant human IgG4 heavy chain constant region which exhibit altered exchange properties.