baber/WOPTO huggingface dataset:
Patent EP-2411512-B1 (EP)
Inventor: HARADA KAZUNORI
IPC: C12N9/58
Filed: 2010-03-19
Granted: 2013-11-20
Abstract: The present invention provides an improved type protease which comprises an amino acid sequence that is at least 75% identical to SEQ ID NO:3, said improved type protease has at least one mutation selected from the group consisting of: (A) replacement of glutamine corresponding to glutamine at position 265 in SEQ ID NO: 3 with an acidic amino acid; and (B) replacement of glutamine at position 266 in SEQ ID NO: 3 with an acidic amino acid, and wherein said improved type protease has milk-clotting activity.
Patent EP-2319524-B1 (EP)
Inventor: JAKOBOVITS AYA
IPC: C12N5/095
Filed: 2004-05-28
Granted: 2013-08-21
Abstract: PSCA and its encoded protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, propylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
Patent EP-2369005-B1 (EP)
Inventor: SKERRA ARNE
IPC: A61K47/42
Filed: 2008-06-20
Granted: 2013-04-03
Abstract: The present invention relates to biologically active proteins comprising at least two domains wherein a first domain of said at least two domains comprises an amino acid sequence having and/or mediating said biological activity and a second domain of said at least two domains comprises an amino acid sequence consisting preferably of at least about 100 amino acid residues forming a random coil conformation whereby said random coil conformation mediates an increased in vivo and/or in vitro stability of said biologically active protein. Furthermore, nucleic acid molecules encoding the inventive biologically active proteins and vectors and cells comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions comprising the compounds of the invention as well as for specific uses of the biologically active proteins, nucleic acid molecules, vectors and cells of the invention.
Patent EP-2384804-B1 (EP)
Inventor: MEERPOHL BERND
IPC: B31B50/25
Filed: 2005-11-08
Granted: 2012-08-22
Abstract: A filter element for separating particles from a gas stream, comprises a filter wall (10) with a number of openings (13) for the raw gas, a second wall (20) located behind the first, which also contains openings, and an intermediate chamber (40) between the two. The second wall has an impact region (26) for the particles that pass through the holes in the first wall. The wall has increased deformability over the filter fold regions.
Patent EP-0008325-B1 (EP)
IPC: F16H55/17
Filed: 1979-06-11
Granted: 1982-05-19
Abstract: Drive for cylinders of an offset printing machine having a gear train constructed of spur gears disposed as drive gears on respective shafts of the cylinders, and including clamping devices for synchronizing rotation of the cylinders, the clamping devices being rotatable with the spur gears respectively associated therewith and having respective gear rims deformable more or less in accordance with an adjustment thereof, including a clamping plate respectively disposed coaxially to the spur gears, the spur gears being helically toothed, and at least two of the clamping devices mounted on the clamping plates, respectively, and acting in radial direction upon the gear rim of the spur gear respectively associated therewith.
Patent EP-0008300-B1 (EP)
IPC: H01H1/08
Filed: 1979-01-15
Granted: 1982-04-21
Abstract: Commutateur reed humecte au mercure dans lequel les contacts electriques de commutation ont une configuration geometrique reduisant au minimum la force magnetique necessaire pour fermer les contacts normalement ouverts en absence de champ magnetique permettant une application necessitant une commutation rapide dans laquelle un retard n'est pas tolerable. Un premier membre magnetique conducteur (11) est porte par une structure isolante de support (10) et presente une structure en gradin materialisee par une extension magnetique conductrice (11b) decalee lateralement par rapport a l'alignement axial de la partie restante du membre et s'etendant parallelement a la direction axiale dans le sens oppose a celui ou se trouve le support. Un second membre conducteur magnetique (13) constitue un element de support d'armature porte sur la structure isolante de support (10) ayant une direction generale alignee avec le premier membre mais separee de ce dernier. Le deuxieme membre conducteur magnetique a aussi une structure en gradin concretisee par une extension conductrice magnetique (13a) decalee lateralement de l'alignement axial, du meme cote que l'extension (11b) du premier membre magnetique conducteur. Une armature magnetique (15) s'etend entre le premier et le second membre magnetique conducteur et possede une longueur telle qu'elle chevauche les portions qui s'etendent axialement, de chaque membre magnetique conducteur et s'ajuste dans chaque gradin en evitant cependant le contact. Un element de ressort de support (16) connecte l'element de support d'armature avec l'armature. Le ressort de support constitue une connexion flexible permettant a l'armature de prendre une position de meilleur alignement avec les premier et second membres magnetiques, position dans laquelle la reluctance magnetique est minimale en presence d'un champ magnetique.
Patent EP-0015479-B1 (EP)
IPC: H01B3/42
Filed: 1980-02-26
Granted: 1983-04-13
Abstract: Heat resistant polymers connected by ester and/or urethane groups and optionally amide- and/or imide groups and/or hydantoin and/or isocyanurate rings are obtained by crosslinking the polymers with trishydroxy alkyl triazolidine -3,5-diones.
Patent EP-0022179-B1 (EP)
IPC: F04B23/02
Filed: 1980-06-06
Granted: 1982-10-06
Abstract: In a device for dosing a liquid effective substance into flowing water, a housing forms a flow path for the water and contains a drive mechanism arranged to be driven by the water. A disposable tank unit is mounted on the housing and includes a dosing pump and an injection valve. The dosing pump is driven by the drive mechanism and withdraws the liquid effective substance from the tank and directs it into the injection valve for introduction into the water flowing through the housing.
Patent EP-0026536-B1 (EP)
IPC: B29C57/00
Filed: 1980-09-24
Granted: 1985-03-20
Abstract: A plastics pipe part 1, both comprises a socket with an annular groove 3 for accommodating a head part 4 of a sealing member 3a as well as a sealing sleeve 5, to be accommodated in a sleeve receiving chamber 6. The head part 4 is retained by a self-centering retaining ring 9. The retaining ring 9 comprises two shoulders 11, 12, interconnected by a flexible connecting part 13, a free space 18 being present between bottom 19 of part 13 and opposite rounding 16 of the pipe part.
Patent EP-0015874-B1 (EP)
IPC: G01M3/26
Filed: 1980-02-25
Granted: 1982-01-27
Abstract: 1. A method of determining the leak rate of a fluid-containing receptacle, in particular a supply line, said fluid-containing receptacle being sealed off and subjected to pressure, which method comprises connecting said receptacle to a tank of fluid, subjecting alternately the fluid in the tank and, accordingly, also in the receptacle, to constant higher and lower pressure, measuring the rates of flow of fluid between tank and receptacle, and using as reference value for the leak rate the difference in the rates of flow at two intervals of time each immediately preceding successive changes of pressure.
Patent EP-0042075-B1 (EP)
IPC: C08F251/00
Filed: 1981-05-21
Granted: 1984-02-22
Abstract: Copolymers of formula I are described <CHEM> in which A is the monomeric unit of a natural or synthetic polymer, m is the degree of polymerization; m and n are different one from the other, and m is a number between about 10 and about 10,000 and n is a number between about 100 and about 250; R is a quaternary ammonium radical; x<-> is an anion. A may be the monomeric unit of starch or the monomeric unit of hydroxyethylcellulose.
Patent EP-0065589-B1 (EP)
IPC: G01R33/04
Filed: 1981-05-26
Granted: 1985-09-11
Abstract: 1. A method of determining a magnetic field by means of a magnetic probe (SON) which has a saturable iron core carrying a winding arrangement (LS), wherein at least one winding of the winding arrangement (LS) is connected to a rectangular, alternating excitation voltage which produces in the saturable iron core an internal magnetic field superimposed on an external magnetic field, e.g. the earth's field, and so changes the saturation conditions of the iron core, and wherein a response signal is derived from at least one winding of the winding arrangement (LS) consisting of induced voltage pulses (U'ind ) as a function of the magnitude of the external magnetic field, characterized in that the pulse duration (t'u ) of the individual induced voltage pulses (U'ind ) is measured and compared with a reference value (tu ) that corresponds to the pulses duration of the induced voltage pulses (Uind ) without the influence of an external magnetic field ; that the difference (tvphi ) between the measured pulse duration (t'u+ ; t'u- ) of the positive and negative voltage pulses (U'ind+ ; U'ind- ) is formed and the reference value (tu ) eliminated, and that from the difference (tvphi ) the field strength is determined and displayed.
Patent EP-0050227-B1 (EP)
IPC: B29C33/20
Filed: 1981-09-21
Granted: 1984-05-02
Abstract: 1. An apparatus for the production of hollow articles from thermoplastic materials, comprising a melting unit (1) and an extrusion die (2) connected thereto, with the aid of which die a hot, plastic, tube-shaped parison (3) is produced ; a mould (6) consisting essentially of two mould halves (4, 5) which in their turn are fastened to movable platens (7, 8) on a clamping unit ; and an additional locking device arranged on the platens (7, 8) and consisting of a tension rod (9, 209) having an inclined surface (10, 210) at its free end, and of a locking member (12, 212) with an actuating device (13), wherein at least two wedge-shaped members (112) are so connected together via a common actuating element, e.g. a displaceable frame (115), that they can be brought into action together, and wherein the actuating device (13) is so controlled that the wedge-shaped members (112) are caused to engage one another to form the pinched seams on the hollow article before the mould halves (4, 5) have completely closed.
Patent EP-0055001-B1 (EP)
IPC: D01D5/12
Filed: 1981-12-12
Granted: 1985-04-10
Abstract: Process for the production of filaments of polyethylene with high modulus and tensile strength, comprising spinning a filler containing solution of a linear polyethylene with a weight-average molecular weight (Mw) of at least 400,000 to form filled filaments and then stretching the filaments.
Patent EP-0038213-B1 (EP)
IPC: A01G9/24
Filed: 1981-04-14
Granted: 1984-04-18
Abstract: A system for the control of temperature and humidity in a greenhouse relies on a heat pump and various sensors for the measurement of temperature and relative humidity both inside and outside the greenhouse. Conditions inside and outside the greenhouse are analysed to fail within a particular class and the classes of weather conditions are matched to provide an appropriate control strategy for the greenhouse. The purpose of the invention is to provide for the optimisation of the extraction of useful heat by means of refrigerative de-humidification of the greenhouse and to utilise this heat to minimise the amount of supplementary heat required for the greenhouse, or as a heat source for other heating purposes. It is also the purpose of the invention to provide for the optimisation of the extraction of purified (distilled) water from water supplied to the plants.
Patent EP-0069810-B1 (EP)
Title: Novel dibenzoxepins, their preparation, compositions containing them and the use of dibenzoxepins in the treatment of allergic conditions
IPC: C07D313/12
Filed: 1981-07-09
Granted: 1986-12-03
Abstract: 6,11-dihydrodibenz[b,e]oxepins of formula: <CHEM> in which R2 and R3 are hydrogen, halogen, CF3 or various N-, O- or S- attached substituents; R4 is hydrogen or various N-, O- or S- attached substituents and R5 is hydrogen or C1-4 alkyl, or R4 and R5 are together oxo, methylene or aryl-substituted methylene; and R1 is 5-tetrazoyl, 3-hydroxy-1,2,5-thiadiazol-4-yl, 4-hydroxy- DELTA <3>-pyrroline-2,5-dione-3-yl or   -@-R6 where R6 is certain O- or N-attached residues, including hydroxy and 2-imino-3-methylthiazolidine, are useful in treating disease, particularly allergic diseases such as asthma. To this end they may be made up into pharmaceutical compositions. Certain of the compounds are novel. The compounds are made by various routes, depending on the nature of the substituents.
Patent EP-0053915-B1 (EP)
IPC: C09B29/34
Filed: 1981-12-03
Granted: 1984-07-04
Abstract: Compounds of formula (I)   <IMAGE> (I)  in which n is 1 or 2, R1 is C1-4 alkyl, C1-4 alkoxy, nitro, amino, halo or hydroxy, m is 0, 1 or 2, R2 is an immunogenic determinant and x is 1 or 2, provided that when n is 1, x is 1 or 2 and there is one diazo moiety at the 3-position or two diazo moieties at the 3- and 5-positions, with respect to the isothiocyanate group, and the hydroxy group is at the 4-position; and provided that when n is 2, x is 1 and the diazo moiety is at the 4-position and the hydroxy groups are at the 3- and 5-positions, are described. The compounds are useful in the preparation of immunoglobulin conjugates for employment in diagnostic techniques.
Patent EP-0073991-B1 (EP)
IPC: A43B5/04
Filed: 1982-08-20
Granted: 1985-05-08
Abstract: The device comprises a bar carried rotatably on the ski boot and provided with first and second oppositely threaded portions rotatively engaged by first and second blocks effective to translate along the bar. To the blocks there are articulated respective ends of first and second connecting rods, both thereof are articulated with their other ends to an adjuster.
Patent EP-0075229-B1 (EP)
IPC: B60Q1/38
Filed: 1982-09-11
Granted: 1985-09-04
Abstract: 1. Electric circuit arrangement for supplying flashing lamps (10, 11) for vehicles, which lamps can be intermittently switched on via a thermal flasher (15a), the flasher (15a) being provided with a switching contact (20) which is connected to the power supply (12) and which is arranged at the free end of a contact arm (21) which is mounted on one side and operates in dependence on temperature and acts in conjunction with a normally-closed contact (22) and in which arrangement the contact arm (21) is to be heated by an electric heater winding (23), one end of which is to be connected to the normally-closed contact (22) and the other end of which is to be connected to at least one flashing lamp (10, 11), characterised in that flasher (15a) and flashing lamps (10, 11) are connected via a turn-indicating switch (16, 16a) to an alternating-current winding (13) of a generator (12) and that the flasher (15a) is provided with a normally-open contact (26) which is connected to at least one further flashing lamp (10b, 11b) and which, alternating with the normally-closed contact (22), works in conjunction with the switching contact (20) of the contact arm (21).
Patent EP-0083280-B1 (EP)
IPC: F41H11/02
Filed: 1982-12-21
Granted: 1988-09-21
Abstract: A rope is pulled between an end member such as a parachute forming a sail with regard to the wind and a main floating anchor located at the other end. This rope is connected at chosen intervals to captive-balloons, each associated with secondary floating anchors. The captive-balloons are chosen to be sensitive to the wind in order to incline themselves with respect to the floating anchor and to respectively support decoys formed by sets of retroreflective trihedrons. Advantageously, the decoys are individually connected in their lower part to floating bodies such as slightly inflated and loaded balloons. The invention has application, in particular, to the simulation of large surface ships.
Patent EP-0086963-B1 (EP)
IPC: B29C45/20
Filed: 1983-01-21
Granted: 1986-09-03
Abstract: This invention relates to a valve gated injection molding system of the type where the melt passage enters the system on general alignment with the valve pin and cavity. The system has a novel valve pin actuating mechanism which is pneumatically operated according to a predetermined timed cycle. A piston which reciprocates in a cylinder has an outer collar portion from which a tongue portion extends inwardly to operatively engage the driven end of the valve pin. The melt passage extends through a portion of the back plate which, in turn, extends through the outer collar portion of the piston and is offset to leave room for the tongue portion of the piston to engage the driven end of the valve pin. Piston rings are located between the piston, back plate and cylinder to prevent excessive air leakage. This center entry system with a pneumatic actuating mechanism provides a more reliable mechanism which may be double acting.
Patent EP-0102444-B1 (EP)
IPC: F16K7/18
Filed: 1983-02-28
Granted: 1986-07-30
Abstract: 1. Multiple-way valve, especially for devices operated by compressed air, having at least one pressure-medium inlet (8, 27) located in a valve housing, having a pressure-medium outlet (10, 32), and having a valve member (4, 24) by means  of which the pressure-medium inlet (8, 27) can be isolated from the pressure-medium outlet (10, 32), and also having means for actuating the valve, which multiple-way valve has the following features : a) the valve member (4, 24) is displaceably arranged in the valve housing in a sealed manner ; b) between the valve member (4, 24) and the inner wall of the valve housing there is arranged as a seal a rolled diaphragm (14, 29) which is fastened on the one side to the valve member (4, 24) and on the other side to the inner wall of the valve housing ; c) there are provided an inlet chamber (17, 26) which is connected to the pressure-medium inlet (8, 27) and an outlet chamber (12, 30) which is connected to the pressure-medium outlet (10, 32) : d) the rolled diaphragm (14, 29) is arranged and designed so that, in dependence on the position of the valve member (4, 24), it closes in a sealed manner a connection between the inlet chamber (17, 26) and the outlet chamber (12, 30), or opens the said connection partially or completely ; e) the inlet chamber (17, 26) and the outlet chamber (12, 30) are separated from one another by the rolled diaphragm (14, 29) ; f) there is provided an additional venting line which can be connected to the outlet chamber (12, 30) via a second outlet (9, 28) ; g) the valve member (4, 24) has a connecting channel (18, 19, 13, 20, 21 ; 36, 37, 40, 31, 33) via which the inlet chamber (17, 26) and the outlet chamber (12, 30) can be connected to one another ; h) the outlet (20, 21 ; 31, 33) of the connecting channel (18, 19, 13, 20, 21 ; 36, 37, 40, 31, 33) that is associated with the outlet chamber (12, 30), the first outlet (10, 32) of the outlet chamber (12, 30) and the second outlet (9, 28) of the outlet chamber (12, 30) are arranged so that, in dependence on the positon of the valve member (4, 24), on the one hand the first outlet (10, 32) and the second outlet (9, 28) of the outlet chamber (12, 30) are opened by the rolled diaphragm (14, 29) while the outlet (20, 21 ; 31, 33) of the connecting channel (18, 19, 13, 20, 21 ; 36, 37, 40, 31, 33) that is associated with the outlet chamber (12, 30), the first outlet (10, 32) of the outlet chamber (12, 30) is covered in a sealed manner by the rolled diaphragm (14, 29), and on the other hand the outlet (20, 21 ; 31, 33) of the connecting channel (18, 19, 13, 20, 21 ; 36, 37, 40, 31, 33) that is associated with the outlet chamber (12, 30) is opened and the second outlet (9, 28) of the outlet chamber (12, 30) is convered in a sealed manner by the roller diaphragm (14, 29) wile the first outlet (10, 32) of the outlet chamber (12, 30) is opened by the roller diaphragm (14, 29).
Patent EP-0089612-B1 (EP)
IPC: B01F5/24
Filed: 1983-03-16
Granted: 1988-04-20
Abstract: Particulate materials are blended in a vessel provided with a plurality of vertically extending conduits therein. The vessel comprises a downwardly converging frustoconically shaped bottom wall which defines the lower region of the vessel. The conduits are provided with opening within the upper region of the vessel and the lower ends of the conduits extend through the bottom wall, each communicating via a corresponding inclined conduit with a solids outlet at the open bottom of the bottom wall. At least one drain conduit communicates between a corresponding opening in the bottom wall and a corresponding inclined conduit. A baffle is disposed within the vessel separating the upper and lower regions and comprises a downwardly converging inverted Igenerally conical portion spaced above the bottom wall and defining therebetween a downwardly converging annular passage. Various arrangements of positioning and spacing of drain conduits and corresponding openings in the bottom wall are disclosed to improve flow, sampling and blending of particulate materials from the lower region of the vessel.
Patent EP-0100845-B1 (EP)
IPC: E04B1/70
Filed: 1983-06-22
Granted: 1988-12-07
Abstract: Reinforcing or carrier elements for plaster are used as electrodes in electro-osmotic dehumidification installations. The elements comprise a carrier body constituted by a flexible net having a surface of synthetic resin in contact with the plaster and the net has filamentary carrier materials incorporated therein. The synthetic resin is a conductive, essentially ion-free thermosetting resin of macromolecular structure, preferably an at least partially cross-linked acrylate polymer having a high surface roughness and containing a small amount of a plasticizer, and forms either the matrix or a coating of the flexible net. The filamentary carrier materials may be carbon or metal filaments. In the use of the dehumidification installation, a voltage alternating between a positive and a negative potential is conducted between the cathode and the anode, the time interval of the positive potential exceeding that of the negative potential.
Patent EP-0101573-B1 (EP)
IPC: F15B11/06
Filed: 1983-07-27
Granted: 1986-01-08
Abstract: 1. Driving device for an one axle manipulator with an adjustment piston shiftable in a pressure cylinder by compressed air in both directions, by means of which piston directly or via intermediate parts a tool adjustable in height, for example a spray gun, is gearably connected, characterised in that both of the pressure chambers (5, 6) adjoined to the adjustment piston (3) in order to equalize the weight power (arrow 8) acting against the adjustment piston are permanently applied to compressed air of different pressure, that both of the pressure chambers (5, 6) via preferably adjustable throttles (19, 21) connectable via control valves (18, 20) are mutually vented and that in order to accelerate leading out the compressed air from the vented pressure chamber (6) when lifting the tool (4), to the pressure chamber a vent valve (22) is connected opened during an adjustable time.
Patent EP-0102609-B1 (EP)
IPC: H03M1/00
Filed: 1983-08-29
Granted: 1989-12-13
Abstract: A digital-analog converter characterized in that reference voltage is divided by a first string-like resistor array (11, 105, 202), whose two adjacent outputs are selected by a first switch array (13, 107, 204) depending upon the contents of upper bits of a digital signal and applied to the both ends of a second string-like resistor array (17, 110, 211), and one of switches in a second switch array (18, 113, 214) is selectively turned on responsive to the contents of lower bits of said digital signal to pick up one of the divided voltages of said second resistor array (17, 112, 211).