Patent SG-11201407890V-A (SG)
Title: Tetrahydropyrazolopyrimidine compounds
Inventor: HAWKINS LYNN D
IPC: A61K31/19
Filed: 2013-05-31
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 5 December 2013 (05.12.2013) WIPOIPCT (10) International Publication Number WO 2013/181579 A3 (51) International Patent Classification: C07D 471/04 (2006.01) A61P 37/00 (2006.01) A61K31/519 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 61/654,023 31 May 2012 (31.05.2012) (74) Agents: WALTERS, Todd R. et al.; Buchanan Ingersoll & Rooney PC, (customer no. 21839), P.O. Box 1404, Al­ exandria, Virginia 22313-1404 (US). PCT/US2013/043679 31 May 2013 (31.05.2013) English (71) Applicant: EISAI R&D MANAGEMENT CO., LTD. [JP/JP]; 6-10, Koishikawa 4-Chome, Bunkyo-ku, Tokyo 112-8088 (JP). (72) Inventor; and (71) Applicant (for US only): HAWKINS, Lynn D. [US/US]; 963 Lowell Road, Concord, Massachusetts 01742 (US). (72) Inventors: BOIVIN, Roch; 18 Strawberry Hill road, North Chelmsford, Massachusetts 01863 (US). CARLSON, Eric; 14 Blair Road, Merrimack, New Hampshire 03054 (US). ENDO, Atsushi; Apt. 1123, 311 Lowell Street, An- dover, Massachusetts 01810 (US). HANSEN, Hans; Apt. 3, 18 Sanborn Avenue, Somerville, Massachusetts 02143 (US). ISHIZAKA, Sally; 110 Mountvale Road, Weston, Massachusetts 02493 (US). MACKEY, Matthew; 52 Henry Avenue, Melrose, Massachusetts 02176 (US). NARAYAN, Sridhar; 22 Thomas Street, Belmont, Mas­ sachusetts 02478 (US). SATOH, Takashi; 21 Paulornette Circle, Andover, Massachusetts 01810 (US). SCHILLER, Shawn; 614 Hilldale Avenue, Haverhill, Massachusetts 01832 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, English MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, us SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a)) (88) Date of publication of the international search report: 27 March 2014 o\ i> •H 00 i-H o CJ (54) Title: TETRAHYDROPYRAZOLOPYRIMIDINE COMPOUNDS (57) Abstract: Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibit­ ors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus eryth­ ematosus (SLE) and lupus nephritis