Patent SG-11201909565W-A (SG)
Title: Production of aspirin-triggered resolvins without the use of aspirin in a dietary omega-3 supplement
Inventor: GUBLER DANIEL
IPC: A61K38/00
Filed: 2018-04-12
Abstract: Methyl Acetylsalicylate Human Metabolism 0 OH 0 Acetyisalicylate Acid (Aspirin) r-o + BASE OH Methyl Salicylate OAc-Containing Group (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 18 October 2018 (18.10.2018) WIP0 I PCT omit VIII °nolo VIII VIII III mo oimIE (10) International Publication Number WO 2018/191505 Al (51) International Patent Classification: A61K 31/616 (2006.01) A61K 31/612 (2006.01) A61K 31/00 (2006.01) A61K 38/00 (2006.01) A61K 31/60 (2006.01) (21) International Application Number: PCT/US2018/027314 (22) International Filing Date: 12 April 2018 (12.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/484,676 12 April 2017 (12.04.2017) US 15/951,755 12 April 2018 (12.04.2018) US (71) Applicant: PERFORMANCE LABS PTE. LTD. [SG/SG]; 2 Shenton Way, #18-01, Sgx Center I, 068804 (SG). (72) Inventor; and (71) Applicant (for US only): GUBLER, Daniel [US/US]; 662 E. 500 N., Orem, UT 84097 (US). (74) Agent: FLORES, Edwin, S. et al.; Chalker Flores, LLP, 14951 North Dallas Parkway, Suite 400, Dallas, TX 75254 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (54) Title: PRODUCTION OF ASPIRIN-TRIGGERED RESOLVINS WITHOUT THE USE OF ASPIRIN IN A DIETARY = OMEGA-3 SUPPLEMENT kr) FIG. (57) : The present invention includes a composition and method of producing aspirin in situ, the method comprising: identifying a subject in need of aspirin or aspirin-like compounds; and providing the subject with a composition comprising: a source of methyl O salicylate, an acetyl donor, and L-Arginine, wherein the composition is effective to produce aspirin-triggered resolvins in the subject \" without the deleterious effect of the aspirin or aspirin-like compounds in the stomach. [Continued on next page] C WO 2018/191505 Al MIDEDIMOMOIDEIREEMOMOHHHINIMOIMMIS UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))