Patent SG-11201807146S-A (SG)
Title: 5-methyl-6-phenyl-4,5-dihydro-2h-pyridazin-3-one derivative
Inventor: KATOH TAKAHIRO
IPC: C07D237/14
Filed: 2017-03-02
Abstract: WO 17 / 15 065 4 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/150654 Al 8 September 2017 (08.09.2017) WIPO I PCT 1111111111111101110101011111010111110 01111001101111111001111111111111110111111 (51) International Patent Classification: C07D 237/02 (2006.01) A61K 31/50 (2006.01) C07D 237/14 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/JP2017/008246 (22) International Filing Date: 2 March 2017 (02.03.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 2016-042535 4 March 2016 (04.03.2016) JP (71) Applicant: OTSUKA PHARMACEUTICAL CO., LTD. [JP/JP]; 2-9, Kanda Tsukasa-machi, Chiyoda-ku, Tokyo, 1018535 (JP). (72) Inventors: KATOH, Takahiro; c/o OTSUKA PHARMA- CEUTICAL CO., LTD., 3-2-27, Otedori, Chuo-ku, Osaka- shi, Osaka, 5400021 (JP). IIDA, Masatoshi; c/o OTSUKA PHARMACEUTICAL CO., LTD., 3-2-27, Otedori, Chuo- ku, Osaka-shi, Osaka, 5400021 (JP). TERAUCHI, Yuki; c/o OTSUKA PHARMACEUTICAL CO., LTD., 3-2-27, Otedori, Chuo-ku, Osaka-shi, Osaka, 5400021 (JP). YAMAGUCHI, Kazuya; c/o OTSUKA PHARMACEUT- ICAL CO., LTD., 3-2-27, Otedori, Chuo-ku, Osaka-shi, Osaka, 5400021 (JP). HIROSE, Toshiyuki; c/o OTSUKA PHARMACEUTICAL CO., LTD., 3-2-27, Otedori, Chuo- ku, Osaka-shi, Osaka, 5400021 (JP). YOKOYAMA, Fu- miharu; c/o OTSUKA PHARMACEUTICAL CO., LTD., 3-2-27, Otedori, Chuo-ku, Osaka-shi, Osaka, 5400021 (JP). NISHIMORI, Hikaru; c/o OTSUKA PHARMA- CEUTICAL CO., LTD., 3-2-27, Otedori, Chuo-ku, Osaka- shi, Osaka, 5400021 (JP). OBUCHI, Yutaka; c/o OT- SUKA PHARMACEUTICAL CO., LTD., 3-2-27, Otedori, Chuo-ku, Osaka-shi, Osaka, 5400021 (JP). NABESHIMA, Hiroshi; c/o OTSUKA PHARMACEUTICAL CO., LTD., 3-2-27, Otedori, Chuo-ku, Osaka-shi, Osaka, 5400021 (JP). TAKAKI, Emiri; c/o OTSUKA PHARMACEUTIC- AL CO., LTD., 3-2-27, Otedori, Chuo-ku, Osaka-shi, Osaka, 5400021 (JP). (74) Agents: SAMEJIMA, Mutsumi et al.; AOYAMA & PARTNERS, Umeda Hankyu Bldg. Office Tower, 8-1, Kakuda-cho, Kita-ku, Osaka-shi, Osaka, 5300017 (JP). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, [Continued on next page] (54) Title: 5-METHYL-6-PHENYL-4,5-DIHYDRO-2H-PYRIDAZIN-3-ONE DERIVATIVE R 2 ( 1 ) (57) : The present invention provides an agent for treating malignant tumor, comprising a compound of formula (1): wherein R 1 to R 4 are hydrogen atom, halogen, or etc., Y is optionally-substituted alkylene group or etc. WO 2017/150654 Al MIDEDIM000101011101010M0E001101H1001111111110110111111 SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Published: GW, KM, ML, MR, NE, SN, TD, TG). — with international search report (Art. 21(3))