baber/WOPTO huggingface dataset:
Patent DE-60325976-D1 (DE)
Inventor: RICE GREGORY E
IPC: G01N30/00
Filed: 2003-08-22
Granted: 2009-03-12
Abstract: This invention relates to methods of analysis, and in particular to methods for the preliminary fractionation of samples in which low abundance molecules of interest, for example proteins, polysaccharides or fatty acids, are present together with more abundant molecules of little or no interest. In particular, the invention relates to methods of depletion of high abundance proteins from biological samples. Products and kits for use in the method are also disclosed, and form part of the invention. In one aspect, the invention provides a method of depleting a high-abundance molecule from a biological sample, comprising the steps of a) subjecting the sample to affinity depletion using an affinity support with high affinity for a high abundance molecule, and/or b) immunodepletion using an affinity support coupled to an antibody directed against whole or previously fractionated plasma or serum.
Patent DE-60328675-D1 (DE)
Inventor: ALKAN SEFIK S
IPC: C07D401/14
Filed: 2003-04-23
Granted: 2009-09-17
Abstract: This invention discloses and claims a new class of indole or benzo[b]thiophera derivatives of formula (I) for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. It has now been found that the compounds of this invention are capable of modulating T helper (Th) cells, Thl/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production   
wherein Z is S or NR.
Patent DE-60335637-D1 (DE)
Inventor: KAMINSKI JOSEPH M
IPC: C12N15/00
Filed: 2003-07-24
Granted: 2011-02-17
Abstract: Disclosed herein are compositions comprising integrating enzymes that can deliver nucleic acids to a target DNA. Additionally, the methods of using the compositions disclosed herein relate to treatments for a variety of infections, conditions, and genetic disorders.
Patent DE-68912233-D1 (DE)
Inventor: LABARRE ANDRE ETIENNE
IPC: G07F17/24
Filed: 1989-07-27
Granted: 1994-02-24
Abstract: The invention relates to an automatic recording and parking management system, particularly above ground, in urban areas. On parking areas connected to this system, the corresponding spaces (3) are each equipped with a retractable locking device (17) for the positioning of the parked vehicles, this device (17) being controlled, during operation, by the monitoring of a conventional detection device (9) of the parked vehicles by a centralised control unit (7) recording and validating the parking instructions of clients on each identified space (3). <IMAGE>
Patent DE-68928107-D1 (DE)
Inventor: SVOMA RODNEY
IPC: A63B49/08
Filed: 1989-08-17
Granted: 1997-07-10
Abstract: A sports racket which is made by joining longitudinal sections of a racket, particularly half sections of a racket, along a plane parallel to the center plane through the playing surface of the racket. The longitudinal sections of the racket define recesses to form hollow spaces within the interior of the racket upon joining of the racket half sections to thereby reduce the weight of the racket while maintaining its strength. This racket construction is also combined with a string suspension system which includes strings which are splayed to alternately contact the racket frame in front of and behind the plane of the playing surface, contributing to the strength and integrity of the frame.
Patent DE-69006274-D1 (DE)
Inventor: MALLION KEITH BLAKENEY
IPC: A61P43/00
Filed: 1990-02-01
Granted: 1994-03-10
Abstract: The invention concerns pharmaceutially useful heterocyclic nitromethane compounds of the formula I:   <IMAGE> I  in which ring Q is a heterocycle of 4 to 7 ring atoms, the fragment completing the ring Q having 2 to 5 atoms, one of which is carbon, oxygen, sulphur or a group of the formula -NRa-, and the remainder are carbon; Ra is hydrogen, (1-6C)alkyl, (2-6C)alkanoyl, trifluoroacetyl, phenyl, benzoyl, or phenyl(1-4C)alkyl, the latter three optionally substituted; and R1R2and R3 are independently hydrogen, hydroxy, (1-6C)alkyl, (1-6C)alkoxy, phenyl, phenoxy or phenyl(1-4C)alkyl, the last three optionally substituted, or two of R1, R2 and R3 situated on adjacent ring carbon atoms and together with said carbon atoms form a benzene ring fused to ring Q, the benzene ring itself optionally substituted, provided that when the fragment completion ring Q is of 3 atoms then at least one of R1, R2 and R3 is hydrogen; and salts thereof. Other aspects of the invention include the production of the novel compounds by analogy processes and pharmaceutical compositions of the novel compounds and of N-(nitromethylsulphonyl)morpholine for use in the treatment of diabetic complications.
Patent DE-69006440-D1 (DE)
Inventor: IJIRI TOMOYA
IPC: H01R9/053
Filed: 1990-08-17
Granted: 1994-03-17
Abstract: A shielded wire connector has an electrically insulating connector body (1) and a holder (2) contiguous to the connector body (1) through pivot means (3). The holder (2) holds a shielded wire (4) having a shield (4c) on its core wire (4a). The connector body (1) has a first and a second terminal member (5,6) adapted to pierce into said shield (4c) and core (4a) respectively, of said shielded wire (4) when the holder (2) holding the shielded wire (4) is turned about the pivot means (3) into direct engagement with the connector body (1).
Patent DE-69006744-D1 (DE)
Inventor: HAKANSSON OLOF
IPC: F01M9/10
Filed: 1990-11-28
Granted: 1994-03-24
Abstract: PCT No. PCT/SE90/00784 Sec. 371 Date Jun. 30, 1992 Sec. 102(e) Date Jun. 30, 1992 PCT Filed Nov. 28, 1990 PCT Pub. No. WO91/08381 PCT Pub. Date Jun. 13, 1991.A device for taking up valve clearance in the valve mechanism of an internal combustion engine, which mechanism includes rocker arms arranged on at least one rocker arm shaft. The take-up occurs by means of an actively adjustable, hydraulically operated take-up means operable between two positions, i.e., a withdrawn position and an extended position, which take-up means is arranged at the operating end of the rocker arms whose valve clearance is to be taken up. The hydraulic pressure for operating the take-up means is achieved by a somewhat increased lubrication pressure in the rocker arm shaft for this type of engine, which pressure for said extension of the take-up means is increased by wholly or partially blocking the normal drainage of the oil.
Patent DE-69009396-D1 (DE)
Inventor: VAN DIS WILLEM
IPC: A47C31/10
Filed: 1990-11-01
Granted: 1994-07-07
Abstract: The cushion comprises a filling (1) and a removable cover (4). To avoid folds developing in the cover, the hanging loosely thereof and to enhance its general appearance, the cover is on its inside and the filling is on its outside provided with releasable mutually fitting connections. These connections can be press studs (10), velcro tape, or a snap connection. Thus the removable cover is kept in its position relative to the filling. According to a preferred embodiment, the : connections fitted on the filling are plates (21) comprising a hole attached to the filling, and the connections attached to the cover are plates or buttons comprising a mushroom-like extension, fitting in the holes, together forming a snap connection. @(11pp Dwg.No.4/6)@.
Patent DE-69011183-D1 (DE)
Inventor: LEMOINE YVES
IPC: C12R1/865
Filed: 1990-03-28
Granted: 1994-09-08
Abstract: The invention relates to an improved system for the production of mature heterologous proteins, and in particular of hirudin, by yeasts, comprising an expression vector containing a sequence coding for the heterologous protein. This improvement is characterised by the amplification of the yeast KEX2 gene coding for the yscF endoprotease. The amplification is carried out either by integration of one or more copies of all or part of the KEX2 gene in the genome of the yeast, or by insertion of one or more copies of all or part of the KEX2 gene in the vector for expression of the heterologous protein. <IMAGE>
Patent DE-69017289-D1 (DE)
Inventor: HATCH RUSSELL BRUCE
IPC: B41F7/26
Filed: 1990-07-06
Granted: 1995-04-06
Abstract: The invention relates to a liquid transfer article, such an an ink roll, and method for producing it, in which the article comprises a substrate coated with a ceramic or metallic carbide coating having engraved in its surface a pattern of wells adapted for receiving a metered quantity of a liquid, such as ink, and wherein the microporosities in the surface of the wells are filled with a film of a vapor-deposited polymer, such as parylene.
Patent DE-69110554-D1 (DE)
Inventor: SIMON JAIME
IPC: A61K51/12
Filed: 1991-06-18
Granted: 1995-07-27
Abstract: Radiopharmaceutical formulations for complexes comprising at least one radionuclide complexed with a ligand, or its physiologically-acceptable salts thereof, especially <1><5><3>samarium-ethylenediaminetetramethylenephosphonic acid, which optionaily contains a divalent metal ion, e.g. calcium, and is frozen, thawed, and then administered by injection. Alternatively, the radiopharmaceutical formulations must contain the divalent metal and are frozen only if the time before administration is sufficiently long to cause concern for radiolysis of the ligand.
Patent DE-69111006-D1 (DE)
Inventor: BOHEN JOSEPH
IPC: C08K5/12
Filed: 1991-04-09
Granted: 1995-08-10
Abstract: Fire resistant hydraulic fluid compositions comprising (a) one or more esters of polyhaloaromatic acids per se or in combination with (b) one or more hydraulic fluids independently selected from mineral oil, poly- alpha -olefins, alkylated aromatics, cycloaliphatics, esters of dibasic acids, polyol esters, polyglycols, silicones, silicate esters, phosphate esters, and halogenated compositions other than (a); a method for imparting fire resistant properties to known hydraulic fluids by adding one or more esters of polyhaloaromatic acids alone or combined; and the use of the inventive compositions as fire resistant hydraulic fluids. The fire resistant compositions may, optionally, contain one or more shear-stable polymers which have been found to increase the fire resistance of the hydraulic fluid composition.
Patent DE-69115537-D1 (DE)
Inventor: SCOTT JOHN DAVID
IPC: B01J23/26
Filed: 1991-03-27
Granted: 1996-02-01
Abstract: 1,1,1,2-tetrafluoroethane (HFA 134a) is manufactured from trichloroethylene by a two-stage process comprising reacting trichloroethylene with hydrogen fluoride in one reactor to form 1,1,1-trifluoro-2-chloroethane (133a) and reacting the 1,1,1-trifluoro-2-chloroethane with hydrogen fluoride in another reactor to form 1,1,1,2-tetrafluoroethane. The invention is characterised by reversing the reactor sequence and passing the entire product stream from the HFA 134a reactor together with trichloroethylene through the 133a reactor and separating 134a and hydrogen chloride from the recycle stream between the 133a reactor and the 134a reactor.
Patent DE-69116203-D1 (DE)
Inventor: KARAKELLE MUTLU
IPC: A61M25/00
Filed: 1991-04-11
Granted: 1996-02-22
Abstract: A radiopaque, optically transparent catheter has a layer of a clear radiopaque polymer encapsulated by a layer of a clear non-toxic biocompatible base polymer. Preferred clear radiopaque polymers are thermoplastic polyurethanes having iodine or bromine atoms covalently bound to the polymer chain. Preferred base polymers are thermoplastic polyurethanes. The encapsulated layer may be a stripe or an annular layer having base polymer layers laminated on both surfaces thereof.
Patent DE-69128944-D1 (DE)
Inventor: BUCKWALTER BRIAN LEE
IPC: C07K14/575
Filed: 1991-04-18
Granted: 1998-04-02
Abstract: The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing natural and recombinantly-derived proteins or polypeptides containing cysteine residues, either naturally or through site specific mutageneses. The pharmaceutical compositions containing said derivatized proteins and/or polypeptides are formulated to provide stable, long-acting compositions of such proteins and/or polypeptides, previously difficult to achieve.
Patent DE-69129990-D1 (DE)
Inventor: FELDMANN MARC THE CHARING CROS
IPC: C07K14/705
Filed: 1991-10-18
Granted: 1998-09-17
Abstract: PCT No. PCT/GB91/01826 Sec. 371 Date May 10, 1993 Sec. 102(e) Date May 10, 1993 PCT Filed Oct. 18, 1991 PCT Pub. No. WO92/07076 PCT Pub. Date Apr. 30, 1992A polypeptide is provided which is capable of binding human TNF alpha  and which has the first three cysteine-rich subdomains, but not the fourth cysteine-rich subdomain, of the extracellular binding domain of a receptor selected from the group consisting of the 55 kD and 75 kD receptors for human TNF alpha . The ability of the polypeptide to bind TNF alpha  means that it can be used for treating diseases mediated by TNF alpha  activity, such as rheumatoid arthritis.
Patent DE-69131448-D1 (DE)
Inventor: SASAKI YUKIHIKO
IPC: C09J109/00
Filed: 1991-03-13
Granted: 1999-08-19
Abstract: A pressure sensitive adhesive of a mutually immiscible first elastomer (styrene-butadiene block copolymer) exhibiting a first glass transition temperature and a second elastomer (e.g., styrene-isoprene-styrene block copolymer) exhibiting a second glass transition temperature greater than the first is tackified by a tackifying system comprising tackifier preferentially miscible with the second elastomer to provide a dynamic mechanical spectrum plot of tangent delta versus temperature in  DEG C showing two separate and distinct glass transition temperature peaks. The mixture exhibits excellent processability and ambient and low temperature adhesive properties.
Patent DE-69132097-D1 (DE)
Inventor: LEE J
IPC: C12Q1/68
Filed: 1991-09-27
Granted: 2000-05-11
Abstract: A chain-termination method of nucleic acid sequence determination is provided wherein nucleoside triphosphate precursors are replaced with their 1-thiotriphosphate analogs in the polymerization step. This substitution results in more uniform bands of electrophoretically separated DNA fragments which, in turn, results in more accurate base determination.
Patent DE-69214998-D1 (DE)
Inventor: MULQUEEN PATRICK J
IPC: A01N43/90
Filed: 1992-04-29
Granted: 1996-12-12
Abstract: A method of reducing the crop plant phytotoxicity of sulfonamide or sulfonylurea herbicide formulations by reducing the pH of the formulation to below the pKa of said herbicide with an inorganic or organic acid and then adding a cationic surfactant to the formulation; in addition, the formulations and the agricultural uses of said formulations in water diluted form constitute a part of this invention.
Patent DE-69218924-D1 (DE)
Inventor: CAMPBELL GREGOR
IPC: H01J37/32
Filed: 1992-02-04
Granted: 1997-05-15
Abstract: A high density ionized plasma is generated in a source chamber using a single loop disposed in a plane that intercepts the central axis of the source chamber perpendicularly or at a lesser angle and spaced from the closed end of the chamber. With a longitudinal magnetic field and an inert or reactive gas injected into the source chamber, excitation of the antenna with RF energy in the 5 to 30 MHz establishes the M=0 excitation mode or components of both the M=0 and M=1 modes. Low frequency whistler waves are created which generate a uniform and high density plasma and high plasma current. The plasma source thus defined is used in combination with process chamber configurations in which static shaped or time modulated magnetic fields enhance the distribution and uniformity of the plasma at a substrate to be etched, deposited or sputtered.
Patent DE-69220281-D1 (DE)
Inventor: LORENZ ROBERT G
IPC: G01S1/00
Filed: 1992-03-18
Granted: 1997-07-17
Abstract: A Global Positioning System (GPS) commercial receiver is provided with a digital processor that can utilize to advantage P-code modulated L1 and L2 satellite signals which have been modulated with an unknown security code. Integration of the L1 and L2 signals, after demodulation by locally generated carrier and P-code signals, is repetitively accomplished over a duration that is estimated to be the period of the modulation code. The C/A-code L1 signal, which is not modulated with the unknown security code, is also used in locking the locally generated carrier and P-code generators in phase with the received L1 and L2 satellite signals. A interpolative technique is used for adjusting the phase of the locally generated carriers and code in increments much smaller than the period clock sources. Those locked phases can then be utilized to determine position, distance, time, etc., as is done in GPS receivers not utilizing the anti-spoofed signals but with increased accuracy and resolution. A novel structure of the GPS receiver radio frequency and intermediate frequency sections, having a specific combination of demodulating frequencies, is also disclosed.
Patent DE-69222676-D1 (DE)
Inventor: FERRARA CARLO
IPC: G04B19/08
Filed: 1992-03-26
Granted: 1997-11-20
Abstract: An analog type clock or watch having at least one hand and a scale of indicia showing time, comprising means for moving said at least one hand along a closed, non-circular path, having a first and a second straight section, parallel to each other and joined respectively at their ends by corresponding semicircular portions, so that the free end of said at least one hand travels along two straight sections and makes two 180 degree movements as it turns to indicate the time; said means comprising a motor element driven at a constant speed, said element being per se known, arranged so as to actuate a driven element to which the inner end of said hand is fixed; said driven element cooperating with guide means arranged to impart an alternately translatory and rotatory movement to said driven element, so that the free end of said hand follows said closed, non-circular route, pointing in succession to marks indicating the time arranged on the dial of said clock or watch. <IMAGE>
Patent DE-69224966-D1 (DE)
Inventor: BRAX VEIKKO
IPC: H04M11/06
Filed: 1992-06-05
Granted: 1998-05-07
Abstract: A method for handling a call coming via a digital transmission system in terminal equipment suitable for speech and data service, the transmission system including at least one connection element which is a speech transmission connection when the call is in speech service mode and which is a data transmission connection rate-adapted in compliance with the CCITT recommendation V.110 or in a like manner and preferably attached to V.24 interfaces when the call is in data service mode. The terminal equipment starts the connection in speech service mode and automatically changes over to data service mode and initiates a procedure for changing the at least one connection element to a data transmission connection upon receipt, in speech mode, of a predetermined audio signal from the connection. The method can make use of a mobile telephone.
Patent DE-69229107-D1 (DE)
Inventor: GUERIN-MARCHAND CLAUDINE
IPC: C07K16/20
Filed: 1992-02-05
Granted: 1999-06-10
Abstract: The present invention relates to an in vitro diagnostic method for malaria in an individual comprising placing a tissue or a biological fluid taken from an individual in contact with a molecule or polypeptide composition, wherein said molecule or polypeptide composition comprises one or more peptide sequences bearing all or part of one or more T epitopes of the proteins resulting from the infectious activity of P. falciparum, under conditions allowing an in vitro immunological reaction to occur between said composition and the antibodies that may be present in the tissue or biological fluid, and in vitro detection of the antigen-antibody complexes formed. The invention further relates to a polypeptide comprising at least one T epitope from a liver-stage specific protein produced by P. falciparum and a vaccine composition directed against malaria comprising a molecule having one or more peptide sequences bearing all or part of one or more T epitopes resulting from the infectious activity of P. falciparum in the hepatic cells.
Patent DE-69232638-D1 (DE)
Inventor: KENNEY MARYANN CULLY
IPC: D21F7/08
Filed: 1992-12-04
Granted: 2002-07-18
Abstract: The present invention relates to an article of paper machine clothing for use in high temperature applications, which article comprises:-   a) a paper contacting surface layer adapted in use to contact a forming paper sheet;   b) a base layer structure; and c) at least one intermediate layer disposed between said surface layer and said base layer structure, characterised in that said surface layer comprises a fibrous or continuous layer constituting a thermal barrier and providing properties of sheet release.   <IMAGE>
Patent DE-69300408-D1 (DE)
Inventor: SCHOSSELER RENE
IPC: F16D66/02
Filed: 1993-03-03
Granted: 1995-10-05
Abstract: Method for producing a device for detecting wear of friction lining, particularly of linings for brake pads, according to which, on one lateral wall of a friction lining, a hole is made whose axis is substantially parallel to the wear surface of the lining, and into this hole is inserted the end of a sheathed electrically conducting wire which is held in position by bonding. Before inserting the sheathed electrically conducting wire (6) into the said hole (4) the end of its sheath (8) is closed off by depositing a drop (9) of curable resin, which is electrically insulating and stable in the entire service temperature range of the lining (2). <IMAGE>
Patent DE-69309190-D1 (DE)
Inventor: BUFFAT BERNARD
IPC: C03C17/23
Filed: 1993-08-18
Granted: 1997-04-30
Abstract: Treatment process with a view to modifying locally the electrical conduction and/or infrared reflection properties of a thin layer based especially on substoichiometric metal oxide(s) and arranged on a transparent substrate, especially glass. This process consists in selectively subjecting the said layer, which has been heated to high temperature, to a "low-energy" ion beam.
Patent DE-69313998-D1 (DE)
Inventor: LAROCHE PIERRE
IPC: E01C23/16
Filed: 1993-12-23
Granted: 1997-10-23
Abstract: An apparatus is described for the distribution of particulate material, such as glass beads onto a marking of paint or the like on a road surface, the apparatus (10) comprising a housing (12), an upper chamber (24) within the housing (12) for the receipt of the beads, a lower chamber (26) within the housing (12) having a downwardly directed opening (48) and a dosing roller (22) positioned between the upper and lower chambers (24), (26) to allow the beads to pass in a controlled manner from the upper chamber (24) to the lower chamber (26). At least one distribution grid (46) is positioned in the lower chamber (26). The apparatus is able to dispense the glass beads at a uniform rate and evenly over the width of the marking, without spillage of the beads onto unwanted areas which can be both wasteful and may be damaging to the environment. <IMAGE>
Patent DE-69321235-D1 (DE)
Inventor: MENART SANDRINE
IPC: C07K14/765
Filed: 1993-07-06
Granted: 1998-10-29
Abstract: The present invention concerns DNA sequences comprising all or part of the K. lactis promoter gene PDC1 or a derivative thereof, and having transcriptional promoter activity. The invention also relates to the use of the sequences for the expression of recombinant genes.
Patent DE-69322184-D1 (DE)
Inventor: ASHBY ALAN MILES
IPC: A61F2/28
Filed: 1993-01-27
Granted: 1999-01-07
Abstract: An orthopaedic instrument for guiding means for preparing the distal end of a human femur to receive an endoprosthetic femoral component characterised by a base component (6,7,8) provided with guide means (8) for guiding cutting means for shaping all of the necessary surfaces (1,2,3,4,5) to receive the femoral component to be fitted once said base component (6,7,8) is fitted to the bone, means (31,27,40,60,80) for aligning said base component on the bone and means (9,27,28) for attaching said base component to the bone after alignment. <IMAGE>