baber/WOPTO huggingface dataset:
Patent UY-25068-A1 (UY)
Title: Formas de dosificación de sertralina de liberación retardada
Inventor: LEWIS FRIEDMAN HYLAR
IPC: A61K9/28
Filed: 1998-06-29
Abstract: Formas de dosificación de sertralina de liberación retardada que reducen el T Max y reducen los efectos secundarios. Las formas están, por lo general, especialmente retardadas por ser sensibles a su posición a lo largo del tracto gastrointestinal, o temporalmente retardadas por estar retardadas durante un período predeterminado, independiente de su posición a lo largo del tracto gastrointestinal. Se presentan ensayos in vivo para identificar dichas formas de dosificación. La sertralina es un inhibidor selectivo de la reabsorción de serotonina, que es útil como agente antidepresivo.
Patent UY-25114-A1 (UY)
Title: Derivados orto-sustituidos de la hidroxicumaranona como agentes antitumorales y antimetastásicos.
Inventor: OLIVA AMBROGIO
IPC: A61K31/37
Filed: 1998-07-29
Abstract: Se describe una benzocumaranona hidroxi substituida de fórmula general (I): en donde R, R', están independientemente entre si, seleccionados entre H, alquilo, estirilo y cicloalquilo, o tomados conjuntamente con el carbono al cual están unidos, forman un grupo cicloalquilo; A esta seleccioando entre los grupo siguientes: (CH2)n, CH2CH=CHCH2, CH2-CH2-CH2, CH2-CHOH-CHOH-CH2, etc; B es N(R1)-(CH2)m-N(R2)- o compuestos de fórmula ll y T significa CH2-C=CH, C=CH, (CH2)p-O-R3, CH=CH-R3, etc y x es 0 ó 1. En particular, B es un radical diamina, piperazina o piperidina. Se describe también el empleo de los compuestos de fórmula (I) (como por ejemplo: 4-(4-(4-(4-fluorobenzamido)piperidin)butoxi)-2-isopropilidencumaran-3-ona) como inhibidores de la unión de uPA al receptor específico uPAR y en particular, su aplicación como agentes antitumorales y antimetastásicos. Composiciones farmacéuticas que contienen una cantidad eficaz de uno o más compuestos de fórmula l, en mezcla con excipientes farmacéuticamente eficaces y/o diluyentes
Patent UY-28230-A1 (UY)
Title: Inhibidores de catepsina s
Inventor: SUN SANXING
Filed: 2004-03-12
Abstract: Esta invención se refiere a compuestos de peptidilo de fórmulas (I) y (II) activos como inhibidores de catepsina S, una proteasa de cisteína. Los compuestos son inhibidores selectivos y reversibles de la catepsina S y son por tanto útiles en el tratamiento de enfermedades autoinmunes y otras. La invención se refiere también a procedimientos para preparar tales compuestos y a composiciones farmacéuticas que los comprenden.
Patent UY-31508-A1 (UY)
Title: Triazolotriazinas y triazolopirazinas y su uso
Inventor: GERISCH DR MICHAEL
IPC: A61K31/427
Filed: 2008-12-03
Abstract: La invencion se refiere a triazolotriazinas y triazolopirazinas sustituidas y a procedimientos para su preparacion, y también a su uso para la preparacion de medicamentos para el tratamiento y/o profilaxis de enfermedades, en particular trastornos hematologicos, preferiblemente de leucopenias y neutropenias.
Patent UY-31993-A1 (UY)
Title: Compuestos de quinoxalina sustituida tipo piperidina puenteada, y usos de los mismos
Inventor: FUCHINO KOUKI
IPC: A61K31/439
Filed: 2009-07-16
Abstract: La invención se refiere a compuestos de Piperidina puenteada tipo quinoxalina sustituidas, composiciones que comprenden una cantidad efectiva de un compuesto de Piperidina puenteada tipo quinoxalina sustituida y métodos para tratar o prevenir una condición, tales como dolor, que comprende administrar a un animal que lo necesita una cantidad efectiva de un compuesto de Piperidina puenteada tipo quinoxalina sustituida.
Patent DZ-3295-A1 (DZ)
Title: Humanized antibodies that sequester amyloid beta peptide
IPC: C12N5/00
Filed: 2001-02-26
Granted: 2001-08-30
Abstract: A method to treat conditions characterized by formation of amyloid plaques both grophylactically and therapeutically is described. The method employs humanized antibodies which sequester soluble Aß peptide from human biological fluids or which preferably specifically bind an epitope contained within position 13-28 of the amyloid beta peptide Aß.
Patent ES-180313-A1 (ES)
Title: Mejoras en o relativas a bobinas de inductancia electrica ajustable
IPC: H01F17/04
Filed: 1947-10-30
Abstract: Mejoras en bobinas de inductancia eléctrica ajustable que comprende dos medios huecos de material magnésico dispuestos para formar una caja que incluye un devanado inductivo fijado a uno de dichos miembros y medios para justar la distancia entre los mismos.
Patent ES-183869-A1 (ES)
Title: UN PROCEDIMIENTO PARA PREPARAR FOSFATO BICáLCICO, PARTIENDO DE UNA SOLUCIoN áCIDA QUE CONTIENE FLuOR, ASi COMO CALCIO Y áCIDO FOSFoRICO.
Filed: 1948-05-28
Abstract: Un procedimiento de preparar fosfato bicálcico poniendo una solución ácida que contiene flúor así como calcio y ácido fosfórico en contacto preferentemente continuo con un agente neutralizador en un medio ácido y separando de la solución el fosfato de cal precipitado procedimiento que se caracteriza por el hecho de que el valor pH se mantiene en todo el proceso de neutralización entre 1 5 y 2 5 con preferencia 2 0.
Patent ES-184395-A1 (ES)
Title: UN PROCEDIMIENTO PARA PREPARAR áCIDO TáNICO AL ÉTER CON HOJAS DE ZUMAQUE
Filed: 1948-06-30
Abstract: Procedimiento para la preparación del ácido tánico al éter caracterizado por el hecho de que se extrae el ácido tánico de la hoja de zumaque.
Patent ES-186474-A1 (ES)
Title: UN PROCEDIMIENTO PARA TOSTAR UN SULFATO METáLICO
Filed: 1948-12-29
Abstract: Procedimiento perfeccionado de tostar un sulfuro metálico en forma triturada en condiciones de fluidificación para oxidarlo caracterizado por mantener una pluralidad de pasos de tostación de fluidificación dispuestos en serie introducir el sulfuro metálico en el primero de dichos pasos efectuar una proporción mayor de oxidación de dicho sulfuro en el primer paso y hacer pasar el sulfuro así parcialmente oxidado desde el primer paso por uno o más sucesivos para seguir oxidando el sulfuro al paso que se introducen el gas oxidante en el último de dichos pasos y se le hace pasar por el paso o pasos anteriores en contracorriente con el sulfuro que pasa por ellos.
Patent ES-192477-A1 (ES)
Title: UN PROCEDIMIENTO O SUCESIoN DE OPERACIONES QUIMICOMECáNICAS PARA LA OBTENCIoN DE PAILAS O SERPENTINES DE HIERRO FUNDIDO
Filed: 1950-04-11
Abstract: Un procedimiento o sucesión de operaciones quimicomecánicas para la obtención de pailas o serpentines de hierro fundido que se caracteriza porque en su primera fase en un cubilote se mezcla carbono total en una proporción de tres cincuenta a cero noventa por ciento; manganeso en la de cero treinta a cero cincuenta por ciento; fósforo en la de cero veinte por ciento a cero cincuenta por ciento y azufre en la de cero cero ocho por ciento a cero quince por ciento y además castina o piedra caliza en proporción adecuada sometiéndose luego a una temperatura de mil a mil doscientos grados obteniéndose así la fusión de tales elementos y formándose la llamada colada.
Patent ES-198175-A1 (ES)
Title: UN MECANISMO DE TRANSMISIoN PARA VEHiCULOS
Filed: 1951-06-04
Abstract: Un mecanismo de transmisión para un vehículo automóvil que tiene un motor de impulsión con una válvula de estrangulación y que incluye un control para la válvula de estrangulación del motor, un árbol de accionamiento destinado a ser impulsado por el motor del vehículo, un árbol movido para accionar el vehículo, medios para crear un mando entre dichos árboles, que incluyen un embrague de fricción para completar el mando cuando está aplicado, y medios controlados por dicho mando de la válvula de estrangulación para aplicar una fuerza de aplicación a dicho embrague que aumenta al abrir la válvula de estrangulación del motor con lo cual el embrague de fricción tiene la capacidad para transmitir un par de giro incrementado inherente a la abertura incrementada de la válvula de estrangulación.
Patent ES-199995-A1 (ES)
Title: Una pantalla luminiscente
Filed: 1951-10-13
Abstract: Una pantalla luminiscente que comprende un producto de reacción de calcinación que contiene silicio, oxígeno y al menos uno de los metales zinc y barilio y al menos uno de los metales aluminio y galio.
Patent ES-295327-A1 (ES)
Title: Rechargeable alkaline cell and liquid phase-containing amalgam anode therefor
IPC: H01M4/42
Filed: 1964-01-15
Abstract: A rechargeable cell utilizing an amalgam of 60-98% Hg and remainder Zn to form a liquid electrode. The cathode may be Cn, Ag, or Mn. A depolariser of HgO, CnO, AgO, Ag 2 O or MnO 2 may be used. Anode container 10 made of silver has a grid of partitions 11 forming cells 12 which contains the amalgam 15. A barrier layer 17 prevents escape of the amalgam. The cathode 20 is contained in a steel shell 21.
Patent ES-299525-A1 (ES)
Title: Apparatus for continuously winding threads and like filamentary material on to a succession of bobbins
IPC: B65H54/28
Filed: 1964-05-05
Abstract: A method of continuously winding yarn on to successive bobbins comprises feeding yarn onto one bobbin through first traversing means, engaging the yarn and swinging the yarn through an arcuate path so that the yarn is lifted out of the first traversing means and placed in the path of a second traversing means, and feeding the yarn onto another bobbin through said second traversing means. In the embodiment shown when the left hand package has reached a predetermined size, or after a predetermined winding time, sleeve 32 moves to the left to release the right hand bell crank lever 28, 30 to allow the empty bobbin to fall onto its driving roller. Rack 36 is also moved to swing arm 44 upwardly to move the yarn out of the traversing guide 8 of the full bobbin to be caught by the castellations of the snare ring 20 mounted on spindle 18 of the empty bobbin and then to fall into the path of the traversing guide of the empty bobbin. Sleeve 32 now, engages the left hand bell crank lever 28, 30 to lift the full bobbin out of engagement with its driving roller. The yarn between the full and empty bobbins is broken by the difference in speeds between the two bobbins or by a severing device. A single driving roller may be provided for one or more pairs of bobbins. In an apparatus described but not forming part of the invention claimed, a series of traversing guides, one for each pair of a plurality of bobbins, are mounted on a cable oscillated by a cam-as in Specification 885,473. Part of the cable is accumulated in a reserve which is varied in size to shift each guide from one bobbin of a pair to the other bobbin.
Patent ES-300895-A1 (ES)
Title: Nut assemblies
IPC: F02M61/16
Filed: 1964-06-11
Abstract: A layer of a flowable metal e.g. cadmium, zinc, copper or tin, is provided between the opposing faces 17, 19, of the securing nut 14 and nozzle member 18 to reduce friction therebetween and prevent transmission of torque to member 18 during tightening up. As shown a steel washer 41 positioned between the nut 14 and member 18 is coated with cadmium alternatively the surface 17 of the nut may be coated.
Patent ES-305323-A1 (ES)
Title: Reciprocatable pneumatic driving cylinder
IPC: F01B11/00
Filed: 1964-10-16
Abstract: A reciprocating pneumatic driving motor comprises a reciprocating piston 9 which divides the motor cylinder 4 into two double acting chambers and is provided with an output piston rod 12 and a working piston rod 13 with opposed faces, the piston rods sliding within fluid tight working chambers separated from the cylinder by seals 17, 17a and connected to the respective working chambers of a sliding valve arranged to feed the two chambers of the cylinder alternately, the working chambers of the valve being connectable to the respective adjacent chambers of the cylinder at the ends of the strokes of the piston rods by means of passages 31, 35 formed in the piston rods. The two sides of the seals are in communication at the ends of the strokes. The sliding valve includes a bleed passage regulator leading to atmosphere from a compressed air inlet to the valve.
Patent ES-321956-A1 (ES)
Title: Improvements in or relating to prefabricated building structures
IPC: E04B1/344
Filed: 1966-01-19
Abstract: A collapsible building pre-packed for easy erection on site comprises two roof members 7 hinged together and connected at their edges to a ceiling member 5 as by nut and bolt connections 8 engaging inclined slots 6 therein as shown. The arrangement is such that when the roof members are lifted relative to the member 5 they give a pitch of 15 whereupon they are fixedly bolted in position with the interposition of stays 14 and gussets 13. Wall panels are pivotally attached to the above unit.
Patent ES-326884-A1 (ES)
Title: Thermoelectric generators
IPC: H01L35/00
Filed: 1966-05-18
Abstract: In a thermoelectric generator adapted to be mounted in a nuclear reactor, the thermoelements 1a, 2a consist of a high proportion (80 -100%) of a fissionable or fertile material such as the oxide, carbide, monosulphide, oxyselenide, nitride or oxysulphide of uranium with a small amount (about 1%) of a doping additive such as carbon, bismuth or tellurium. The elements, which are of alternate N and P type, are in powder form and are strongly compressed by clamping them between end terminals 7a, 8a. They are housed in a stainless steel tube 10a with an electrically insulating lining 11a and are interposed by insulating rings and discs 3a, 4a so shaped that the successive thermo-junctions 5a, 6a are located at the centre and the periphery of the tube, respectively, to provide a zig-zag current path through the generator. The tube 10a is mounted in a reactor channel 25 through which cooling fluid is circulated, and the reactor fuel may consist entirely of such generators, so that the energy of the reactor is converted directly into electricity, or of both generators and conventional nuclear fuel cartridges so that the output of the generators can be employed for monitoring the reactor. The Specification gives numerical values of the thermoelectric power, resistivity, thermal conductivity and quality factor of several exemplary thermoelements. In an alternative embodiment (Figure 1, not shown) the thermoelements are of normal non-fissionable material and are formed as rings mounted on an inner tube (12) which may be filled with polonium. The disintegration of the polonium provides heat for the hot junctions of the generator.
Patent ES-334983-A1 (ES)
Title: Improvements in or relating to Light-Sensitive Diazotype Materials
IPC: G03C1/58
Filed: 1966-12-27
Abstract: A two-component diazotype material comprises a support coated with a diazonium salt and 2- chloro-resorcinol. The light-sensitive layer may also contain silica.
Patent ES-340997-A1 (ES)
Title: Purification of enzyme inhibitors
IPC: C12N11/08
Filed: 1967-05-26
Abstract: Proteolytic enzyme inhibitors are purified (concentrated) by contacting an impure aqueous solution of the inhibitor with a waterinsoluble polymer-enzyme combination material whereby at least some of the inhibitor is sorbed by the combination material, separating the combination material from the unsorbed aqueous phase, and desorbing a purified aqueous solution of the inactvator from the combination material, the latter having been formed by contact of a proteolytic enzyme, inhibitable by the inhibitor, with a polymeric material cross-linkable by this proteolytic enzyme. The inhibitor may be trypsin, kunitz or kallikrein inhibitors the enzyme may be trypsin, chymotrypsin or kall-krein and examples of suitable polymeric material are ethylene-maleic anhydride copolymer, maleic anhydride-vinylpyrrolidone copolymer and methacrylic acid-methacrylic acid-3-fluoroanilide copolymer. In a modification of the process, the combination material is water-soluble and, as the impure aqueous solution, serum containing the inactivator is used. The inhibitor is subsequently desorbed by shifting the pH and/ or modifying the ion concentration and/or displacement by means of competitive inhibitors or enzymes e.g. tryptamine, n-butyl-amine or epsilon-amino caproic acid for trypsin, and/ or by the addition of substances, such as urea, which are capable of loosening or dissolving molecular interactions, possibly by a reversible denaturation of the proteins concerned.
Patent ES-347204-A1 (ES)
Title: Process for the Production of 2,5-Diacylamino-1,4-Benzoquinones
IPC: C07C233/00
Filed: 1967-11-15
Abstract: 2,5 - Diacylamino - 1,4 - benzoquinones, optionally halogenated in the 3- and 5-positions, are made by a process comprising (a) reducing 2,5 - diamino - 1,4 - benzoquinone, optionally halogenated in the 3- and 5-positions, to produce the corresponding 2,5-diamino-1,4-dihydroxybenzene, (b) reacting the latter with at least two equivalents of an acylating agent (or at least one equivalent each of two acylating agents) and (c) oxidizing the resultant 2,5- diacylamino - 1,4 - dihydroxybenzene to yield the corresponding quinone. The preferred reducing agent for use in step (a) is sodium dithionite, but other suitable reducing agents are specified also. The acylating agent used in step (b) may be not only a halide or anhydride of an aliphatic, araliphatic, aromatic or heterocyclic carboxylic acid but also a chloroformic acid ester, a halogenated triazine or pyrimidine derivative, a ketene or an isocyanate. Many suitable acylating agents are specified. The preferred oxidizing agent for use in step (c) is nitric acid, but other suitable oxidizing agents are specified also.
Patent ES-347865-A1 (ES)
Title: Welded cylinder and crankshaft housing
IPC: F02F7/00
Filed: 1967-12-01
Abstract: A cylinder block and crank-case 11 is formed of intermediate and end sections 12, 13, welded together, each section including a bearing supporting wall 19, 20, having an aperture 17 for a crank-shaft bearing. Each intermediate section includes the halves 15 of adjacent cylinder jackets and comprises longitudinal walls 30, 31, the upper part 31 of the supporting wall 19 being bifurcated to provide bearing supports 38 for a cam-shaft. The supporting walls 19, 20 may be cast or may be formed of sheet metal plates welded e.g. along lines 23, 24. The wall 31 is provided with cooling passages 45 feeding the cooling spaces of the cylinder jackets in which cylinder liners are fitted. To the ends of the engine block are fitted casings 49, Fig.4, containing the valve driving gear and vibration dampers.
Patent ES-348061-A1 (ES)
Title: Substituted 1-dimethylamino pentanes and heptanes
IPC: C07D215/12
Filed: 1967-12-07
Abstract: Novel compounds I in which Ar is cyclohexyl, phenyl, naphthyl (said phenyl or naphthyl being optionally substituted by one or more amino, nitro, hydroxy or C 1-2 alkoxy groups or halogen atoms), thienyl, furyl, quinolyl, benzimidazolyl, pyridyl, pyrazinyl, pyrimidinyl, quinoxalinyl or pyridazinyl R is a C 1-5 saturated or unsaturated, linear or branched-chain aliphatic radical which may optionally be substituted by an ethoxy, hydroxy or dimethylamino radical and R1 and R11 each represents H, or a C 1-3 aliphatic radical or together with the adjacent nitrogen atom form a heterocyclic radical and their acid addition salts are prepared by: (a) reduction of the corresponding amides with lithium aluminium hydride or by catalytic hydrogenation (b) alkylation of an amine with an alkyl halide or when R1 and R11 are methyl with a formaldehyde-formic acid mixture or (c) treating a derivative by the Mannich reaction using an amine HNR1(R11), followed in a, b or c by salt formation, if desired. Intermediates isolated are the amides prepared by alkylation of amides or reacting acids Ar-CH(R)-COOH with amines HNR1(R11) the acids Ar-CH(R)- COOH, prepared by alkylation of acids Ar-CH 2 -COOH or hydrolysis of nitriles Ar-CH(R)-CN and the nitriles Ar-CH(R)- CN, prepared by alkylation of nitriles Ar-CH 2 -CN. Pharmaceutical compositions comprise a compound I in conjunction with a suitable excipient, are administered orally, parenterally, rectally or topically and have cardio-vascular, diuretic and spasmolytic properties.
Patent ES-354921-A1 (ES)
Title: Shuttleless looms
IPC: D03D47/23
Filed: 1968-05-30
Abstract: A driving mechanism for a weft inserter which enters the shed empty and pulls the weft with it as it retracts comprises a crank operated lever 17 which it pivoted at one end to a pivoted arm 18 and is pivoted to a slide 21, attached to the inserter, at its other end and a stabilising bar 1 which is pivoted at one end to the pivot 16 of the crank and at its other end 1" is pivoted under the guide 22 for the inserter. The end 1# of the stabilising bar may be pivoted on a framework fixed to the floor adjacent the loom.
Patent ES-355323-A1 (ES)
Title: Portable electrolysis apparatus
IPC: C25D17/00
Filed: 1968-06-12
Abstract: Portable apparatus for carrying out electrolytic operations comprises a case 1 with lid 3, and divided internally into two separate zones the first including means for connection to a mains electrical supply, and means for controlling and adjusting the electric current and feeding it to rods 18, 19 overhanging the second zone which contains a removable basin 16 for holding an electrolytic bath, workpieces and counter-electrodes in operation being suspended from the rods. An electrical resistor may provide heating for the bath and the first zone may include a current transformer/rectifier and a filter network, and is provided with a control panel 9. The apparatus may be used for electrolytic degreasing, and for the deposition of copper, nickel, silver, gold or rhodium.
Patent ES-355970-A1 (ES)
Title: Herbicidal compositions
IPC: C07D213/22
Filed: 1968-07-10
Abstract: The invention comprises solid complexes of a herbicidal bipyridylium quaternary salt and 1-4 molecular proportions of a complexing agent which contains an aromatic or heterocyclic nucleus bearing one or more hydroxy, amino or mercapto group, being other than p-phenylene diamine, aniline or hydroquinone. The complexes are prepared by mixing the components in aqueous or alcoholic solution, a solid product crystallizing immediately or on evaporation of the solvent. Complexes prepared in aqueous media often contain water as lattice hydration. Anhydrous products are obtained by drying, e.g., at 100 C. Specified complexing agents are p-aminophenol, catechol, phloroglucinol, 3,4- dihydroxybenzoic acid, p-aminobenzoic acid, [alpha] - naphthylamine, o - aminobenzenethiol, 2- mercaptopyridine, and 2-mercapto-benzimidazole. Examples relate to complexes of 1,11- dimethyl - 4,41 - bipyridylium dichloride, diphloroglucinate and di-p-nitrophenate, 1,11- di - (2 - hydroxyethyl) - 4,41 - bipyridylium dichloride and 1,11 - di - (3,5 - dimethylmorpholinocarbonylmethyl) - 4,41 - bipyridylium dichloride. The complexes possess herbicidal properties.
Patent ES-360716-A1 (ES)
Title: Benzenesulphonyl-Ureas and process for preparing them
IPC: C07C303/40
Filed: 1968-11-26
Abstract: Novel sulphonyl-ureas I (including salts thereof) in which Y represents a -CH 2 .CH 2 -, -CH (Me)-CH 2 -or -CH 2 -CH(Me)- group R represents a C 1-5 alkyl radical or a C 1-4 alkenyl, methoxymethyl, ethoxymethyl, methoxyethyl or ethoxyethyl radical X represents a halogen atom, a C 1-4 , straight or branched alkyl radical, a C 1-4 alkoxy radical or a -CF 3 group R1 represents (a) a C 3-6 alkyl radical (b) a C 5-8 cycloalkyl radical (c) a cyclohexenyl or methylcyclohexenyl radical (d) a cyclohexyl radical substituted by 1 or 2 alkyl (C 1 or C 2 ) groups (e) a chlorocyclohexyl radical or a C 1-4 alkoxy-cyclohexyl radical (f) an endomethylene - cyclohexyl, endomethylene - cyclohexenyl, endomethylene - cyclohexylmethyl or endomethylene - cyclohexenylmethyl radical (g) a nortricyclyl radical or (h) an adamantyl radical, are prepared utilizing standard methods. Intermediate benzenesulphonyl-carbamic acid esters, -ureas and -thioureas and benzenesulphonamides {all substituted at the p-position by the (X)(OR)C 6 H 3 .CSNH.Y- group} are also described. Pharmaceutical preparations having hypoglycaemic and blood sugar lowering action contain as active ingredient Compounds I and are suitably in tablet form.