baber/WOPTO huggingface dataset:
Patent DE-60335702-D1 (DE)
Inventor: EL-GEWELY MOHAMMED RAAFAT
IPC: C12N15/10
Filed: 2003-01-23
Granted: 2011-02-24
Abstract: The present invention provides a peptide having 2 to 10 amino acids or a derivative thereof which is able to restore wild type function of human p53, for use in therapy; and a method of screening a library of molecules for the ability of members of that library to restore or modify the function of a target protein in an intra-cellular environment, which method comprises introducing the library into host cells which have a reporter system which allows the identification of those cells in which the function of the target protein has been restored or modified.
Patent DE-68906521-D1 (DE)
Inventor: PILLING RICHARD L
IPC: C07C329/00
Filed: 1989-12-13
Granted: 1993-06-17
Abstract: Particles of thiocarbonate salts, thioesters or complexes are stabilized by being isolated from contact with water, CO2 and oxygen and are encapsulated in a coating effective to prevent future contact of the particles with water, CO2 and oxygen. The particles are preferably prepared in an environment from which water, CO2 and oxygen are excluded. The coating may be a wax, a water-free oil or grease, sulfur or a natural or synthetic polymerizable resin. Various preparative and encapsulating techniques are disclosed.
Patent DE-68910190-D1 (DE)
Inventor: DUNLOP JOHN A
IPC: B22F3/00
Filed: 1989-05-31
Granted: 1993-12-02
Abstract: Tungsten-titanium sputtering targets with improved characteristics are made from high-purity tungsten powder and a second powder consisting of high-purity titanium hydride powder or high-purity titanium hydride powder and high-purity titanium powder. The second powder contains at least 5%, preferably 25% to 100% by weight of titanium hydride powder. A powder mixture having a binodal particle size distribution with respect to the tungsten and second powders is placed under a containment pressure in a die. The die is heated in a vacuum hot-press chamber to a temperature sufficient to dehydride the titanium hydride, and to remove gases and alkali metals. The die is then heated to a second temperature in the range of 1350 to 1550<o>C while maintaining the containment pressure and vacuum. A compaction force in the range of 2000 to 5000 psi is then applied to form a compact. The compaction force and vacuum are subsequently released and the compact is cooled. The compact is easily machined to give a sputtering target having a density of at least 95%, preferably, at least 100% of theoretical density, a total gas content of less than 850 ppm, a carbon content of less than 100 ppm and low particulates upon sputtering.
Patent DE-68915301-D1 (DE)
Inventor: ASAHI SATORU
IPC: C12P17/10
Filed: 1989-02-14
Granted: 1994-06-23
Abstract: A DNA having a pyrimidine analogue resistance gene region is obtained from chromosome DNA of a microorganism of the genus Bacillus resistant to pyrimidine analogues and capable of producing uracil and/or uridine. The DNA is incorporated into a plasmid and a microorganism of the genera Escherichia and Bacillus is transformed with the plasmid. The resulting transformants produce a large amount of uracil and/or uridine in culture medium.
Patent DE-68916959-D1 (DE)
Inventor: URRY DAN
IPC: B01D71/74
Filed: 1989-02-15
Granted: 1994-08-25
Abstract: A mechanochemical engine capable of desalinating sea water or brackish water by the conversion of mechanical work to chemical work, which comprises: a) a housing containing an elastomeric material capable of being stretched, to thereby allow salt-diminished water to move into the elastomeric material, while substantially repelling solvated salt ions from entry thereto, b) means for stretching and relaxing said elastomeric material in said housing, in connection with said elastomeric material; and c) means for uptake of sea water or brackish water into said housing, means for draining concentrated salt water from said housing, and means for draining desalinated water from said housing.
Patent DE-68919326-D1 (DE)
Inventor: CAVAZZA GILBERT
IPC: G03F7/16
Filed: 1989-09-07
Granted: 1994-12-15
Abstract: Process and apparatus for the uniform application of a resist layer to a substrate, characterised in that it comprises a turntable (1) receiving the substrate (3) and equipped with means for immobilising the substrate on the table, so that the rotation of the table (1) causes the resist to be spread in a thin layer on the surface of the substrate. A concentric cover (3) is placed on top of the circular table (1), and this cover together with the table is set in rotation, at the same time confining the gaseous volume consisting of solvent in suspension preserving the properties of the resist in solution during the spreading cycle and forming the internal atmosphere in which the substrate is placed, this volume being driven in rotation substantially in synchronism with the table and cover. 
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Patent DE-68921537-D1 (DE)
Inventor: CARLSON JOSEPH W
IPC: G01R33/341
Filed: 1989-01-10
Granted: 1995-04-13
Abstract: The signal-to-noise ratio achievable for received nuclear magnetic resonance RF signals in a magnetic resonance imaging system is increased by (a) using relatively wider strips of conductor so as to reduce coil loading by the sample and (b) the use of curved edges on a coil conductor so as to reduce "hot spots" located near the conductor surfaces.
Patent DE-68925804-D1 (DE)
Inventor: NIIMI HIROJI MITSUI PETROCHEMI
IPC: B29C48/45
Filed: 1989-12-20
Granted: 1996-04-04
Abstract: A process for molding a saturated crystalline polyester resin into a desired shape by supplying said resin to a molding machine, which comprises heating the resin above its melting point and molding the substantially molten resin into the desired shape such that the temperature Tc2 of the molded article obtained thereby and the crystallizing temperature Tc1 of the starting saturated crystalline polyester resin, satisfy the relationship of Tc1 - 20 </= Tc2 </= Tc1.
Patent DE-68925990-D1 (DE)
Inventor: JEFFORD CHARLES W UNIV DE GENE
IPC: A61K31/38
Filed: 1989-04-17
Granted: 1996-04-25
Abstract: 1,2,4-trioxanes have pharmacological activities, apart from anti-malarial activity. In particular, 1,2,4-trioxanes have antiparasiticidal activity, embracing activity not only against other protozoa apart from Plasmodium spp, but also activity against helminths.
Patent DE-68927575-D1 (DE)
Inventor: FELIX KENNETH A
IPC: H04B7/26
Filed: 1989-01-23
Granted: 1997-02-06
Abstract: A method of handoff for use at base sites (110) of a cellular telephone system for handing off from one of the base sites to another one of the base sites at least one of a plurality of cellular telephones (102) each transceiving data packets and sharing a cellular radio channel of the cellular telephone system, which channel may be packet-switched or digital. A handoff message is sent to one of the active ones of the plurality of cellular telephones in response to determined system loading or signal characteristic, as exemplified in FIG. 7. <IMAGE>
Patent DE-69003682-D1 (DE)
Inventor: DAVIES LAWRENCE
IPC: E06B3/66
Filed: 1990-07-03
Granted: 1993-11-04
Abstract: A spacer for separating panes of glass in a sealed window unit is formed of a thermosetting resin reinforced longitudinally with continuously extending glass fibres. A layer of a foil material is introduced into the part during the pultrusion process so that the foil is embedded within the part and defines a moisture impermeable layer in the outer wall of the part. The foil can be carried into the part on a layer of paper or polyester which combines with the resin in a bonding action.
Patent DE-69012286-D1 (DE)
Inventor: GENOVA CALOGERO
IPC: C07C309/04
Filed: 1990-11-22
Granted: 1994-10-13
Abstract: A process for separating and recovering paraffin sulphonic acids from mixtures with water and sulphuric acid is described, consisting of:   bringing such a mixture into contact under extraction conditions with a saturated aliphatic or cycloaliphatic liquid hydrocarbon; separating an aqueous liquid phase containing sulphuric acid from an organic liquid phase consisting of the extraction solvent containing the paraffin sulphonic acids; and recovering the paraffin sulphonic acids from said organic liquid phase.   The process is particularly applicable to products obtained from processes involving the sulphoxidation of paraffins with sulphur dioxide and oxygen, catalyzed by U.V. radiation.
Patent DE-69018209-D1 (DE)
Inventor: BUEYUEKKOCA EDIP PROF DR
IPC: A61K47/48
Filed: 1990-12-13
Granted: 1995-05-04
Abstract: An immunomodulating agent comprises at least one molecule of an active component held in an excited state, which immunomodulating agent is thereby capable of exhibiting its immunomodulating effect. The active component may be held in its excited state by means of a complex additionally comprising halogen, oxygen and alkali metal atoms. The immunomodulating agent can be prepared by incorporating the active component in a mixture of oxygen and/or ozone, halogen and an inert gas under pressure, directing the mixture containing the active component at a rotating body of a substance capable of vaporization, directing at the rotating body a laser so as to effect said vaporization, and allowing the said mixture and the vaporized substance to expand into a vacuum and thereby form a complex, whereby the active component assumes an excited state.
Patent DE-69026820-D1 (DE)
Inventor: SZOKA FRANCIS
IPC: A61K51/00
Filed: 1990-03-28
Granted: 1996-06-05
Abstract: Liposome and lipidic particle formulations of compounds are prepared by dissolving in a solution of liposome-forming lipids in an aprotic solvent such as DMSO, optionally containing a lipid-solubilizing amount of a lower alkanol, and injecting the resulting solution into an aqueous solution. The resulting liposome or lipidic particle suspension may then be dialyzed or otherwise concentrated. This method is particularly useful for compounds which are poorly-soluble in aqueous solution, but is generally useful for any compound or combination of compounds which can be dissolved in the aprotic solvent or aprotic solvent/lower alkanol mixture.
Patent DE-69033713-D1 (DE)
Inventor: SCARPA IOANNIS
IPC: B01J20/32
Filed: 1990-06-29
Granted: 2001-04-19
Abstract: This invention relates to an improved cellulose chromatography support and, in particular, to substantially spherical, high density cellulose particles. This invention also relates to a method of making these spherical, high density cellulose particles and, in particular, to a method for forming spherical cellulose from a high molecular weight viscose in a stable emulsion of a liquid carrier and emulsifying agents.
Patent DE-69102421-D1 (DE)
Inventor: NORDAL PER-ERIK
IPC: G11B7/0045
Filed: 1991-01-17
Granted: 1994-07-14
Abstract: PCT No. PCT/NO91/00006 Sec. 371 Date Sep. 9, 1992 Sec. 102(e) Date Sep. 9, 1992 PCT Filed Jan. 17, 1991 PCT Pub. No. WO91/11804 PCT Pub. Date Aug. 8, 1991.An optical data storage medium with burn-film having changeable optical properties, for example, changeable reflective power as a result of sufficiently intense illumination, due to hole-burning in the film, is provided with optical structures close to the burn-film for focusing and positioning during recording and reading of individually interpretable data bits (spots). The optical structures are preferably monodisperse, transparent spheres with a diameter in the range of 1-100  mu m. Illumination is performed selectively from a number of predetermined angles ( THETA i,  phi j) during recording and reading, and the number of individual data spots under each sphere corresponds roughly to the number of angles.
Patent DE-69106715-D1 (DE)
Inventor: STEVENS RODNEY
IPC: A61K31/505
Filed: 1991-10-01
Granted: 1995-02-23
Abstract: PCT No. PCT/US91/07045 Sec. 371 Date Apr. 21, 1992 Sec. 102(e) Date Apr. 21, 1992 PCT Filed Oct. 1, 1991.Alkoxy substituted indole derivatives as inhibitors of lipoxygenase and useful as antiallergy and antiinflammatory agents.
Patent DE-69116148-D1 (DE)
Inventor: BARZ RICHARD LEE
IPC: A23C19/097
Filed: 1991-10-02
Granted: 1996-02-15
Abstract: In the manufacture of mozzarella cheese, aging can be dispensed with if the process is controlled to yield a combined moisture and wet milkfat content of at least about 70 weight percent, and the cheese will provide acceptable bake performance under typical cooking conditions used in the pizza industry today. Within about 48 hours after brining, the cheese should either be used or frozen. This discovery saves at least seven days of aging and permits the use of a continuous process of making mozzarella, which, from pasteurization to loading of the frozen product on the truck, can be performed in as little time as eight hours. In the continuous process, the hot stretched cheese from the kneading machine is extruded directly into cold brine. After the cheese has cooled sufficiently, it can be comminuted and frozen by independent quick freezing, preferably in a fluidized bed freezer. Salt preferably is mixed into the cheese during the kneading step.
Patent DE-69120368-D1 (DE)
Inventor: ADAMS STEVEN PAUL
IPC: A61P31/12
Filed: 1991-10-09
Granted: 1996-07-25
Abstract: Azido-substituted fatty acid analogs which are useful in the fatty acid acylation of peptides and proteins and as antiviral agents are disclosed having the following chemical structure: Z - (CH2)xCOOR wherein     Z = azido, tetrazolyl or triazolyl     R = H or C1-C8 alkyl, and     x = 8-12 or structure (I) as defined above and wherein a methylene group from carbon position 3 to within 2 carbons of Z is replaced with oxygen or sulfur.
Patent DE-69124546-D1 (DE)
Inventor: VAN GYSEL AUGUST
IPC: C07D207/448
Filed: 1991-05-31
Granted: 1997-03-20
Abstract: Process for the manufacture of N-phenylmaleimide, in which maleic anhydride is reacted with aniline in a single stage at elevated temperature in the presence of a water-immiscible organic solvent capable of forming an azeotrope with water and of p-toluenesulphonic acid as catalyst. 
<??>According to the invention the recovery of N-phenylmaleimide comprises the following successive stages: 
 
  (a) the reaction mixture is treated in a dilution and filtration zone in which it is diluted with an additional quantity of solvent, the dilute mixture being subjected to a low-temperature filtration in order to separate off a solid cake containing the catalyst and the impurities, and a filtrate consisting of a solution of N-phenylmaleimide in the solvent, and 
  (b) this solution of N-phenylmaleimide is subjected to a distillation at reduced pressure so as to separate off successively the solvent and N-phenylmaleimide of at least 99% purity, whereas the distillation residue is treated exactly as indicated in (a) above in a dilution and filtration zone for recovering the N-phenylmaleimide therefrom, the filtrate being returned to stage (a) to be used for diluting the reaction mixture for the synthesis which follows. 
 
<??>In addition, the filter cakes from stages (a) and (b) are washed with the solvent obtained by distillation in stage (b) and the washing solvents are recycled to the stage of synthesis of N-phenylmaleimide and/or to the dilution zones. 
<??>A N-phenylmaleimide of high purity is obtained in an overall yield which exceeds 86 mol%; the problem of water pollution is reduced to a minimum.
Patent DE-69133528-D1 (DE)
Inventor: LEVINE ARNOLD J
IPC: C12Q1/68
Filed: 1991-06-27
Granted: 2006-06-14
Abstract: A panel of probes detects and distinguishes between sets of human p53 gene or protein mutations that frequently occur or are selected for in pre-cancer and cancer cells. Each set gives rise to a phenotype that is different from that of wild-type p53 and of at least one other set of p53 mutants.
Patent DE-69200293-D1 (DE)
Inventor: FERRAGUT JEAN-PIERRE
IPC: B28B7/34
Filed: 1992-03-20
Granted: 1994-09-08
Abstract: In this mould, each half mould (2) comprises a base (3) of a known type, for instance made of aluminium, equipped with a coating (6) comprising an impression of a shape complementary to that of the article (5) to be moulded, this coating being made from a porous, abrasion-resistant material, each half mould comprising a network of capillary piercings (12) opening into the coating (6) and fed from ducts (8) linked to a source of pressurised water vapour during the phase of pressing an article. Application to the manufacture of clay articles, such as tiles. <IMAGE>
Patent DE-69200432-D1 (DE)
Inventor: BERGETZ CARL A
IPC: F16M11/04
Filed: 1992-05-29
Granted: 1994-10-27
Abstract: A mounting assembly for an electrical appliance such as a television receiver (22) or the like that has a mounting bracket (14) which is capable of being mounted either on a horizontal surface, such as a ceiling, or on a vertical surface, such as a wall. the mounting bracket (14) rotatably receives a support arm (30) which extends from the mounting bracket (14) to a support tray (18) upon which the appliance (22) is mounted. the support arm (30) has a generally vertical first portion (32) and a generally horizontal second portion (34). An extension (40) of the support arm second portion (34) extends transversely from the support arm (30) and supportingly contacts the support tray (18), which is fixed to a pair of opposing endcaps (54a, 54b) of the extension (40). An adjustment means (60) interconnects the support tray (18) with the support arm (30) and permits the elevation of the support tray (18) to be selectively adjusted. <IMAGE>
Patent DE-69212803-D1 (DE)
Inventor: MOTTINO ALESSANDRO
IPC: B60R9/042
Filed: 1992-06-17
Granted: 1996-09-19
Abstract: The present invention relates to a device for loading, unloading and carrying a bycicle in an upright position on the roof of a motor vehicle provided with a pair of transverse carrier rails (5, 12), comprising a shaped tube (1) having its base pivotally connected to a support (4) fastened to a first carrier rail, adapted to be rotated in a continuous manner from a lowered position for the engagement or disengagement of the bicycle frame (27), to a raised position for transporting the bicycle. There are further provided means for supporting and securing the bicycle front wheel and the bicycle frame, that are fastened to the second carrier bar (12) and to the free end of the tube (1), respectively. <IMAGE>
Patent DE-69214782-D1 (DE)
Inventor: LEE KYUN CHEOL
IPC: A43B7/08
Filed: 1992-12-18
Granted: 1996-11-28
Abstract: A self-ventilating device for a shoe, including an air-pumping member disposed in the heel portion of the insole thereof, an ankle-protecting air bag disposed in the heel portion of the insole thereof, an ankle-protecting air bag disposed in the interior of the upper thereof, and an automatic air-controlling member communicating with the air-pumping member and ankle-protecting air bag, whereby the shoe can be effectively ventilated and protect the ankle. <IMAGE>
Patent DE-69300876-D1 (DE)
Inventor: MEYNET CORDONNIER BERNARD
IPC: E05B9/10
Filed: 1993-01-22
Granted: 1996-01-11
Abstract: - Lock-making. - The lock consists of     . a sturdy rectilinear beam (32), . two shells (6a) fitted onto the end parts of the beam and delimiting two open coaxial cylindrical receptacles, . two bushes (7a, 7b) mounted in the receptacles and containing the cylinders (17a, 17b) which are connected by means of the driver (23),   . and means of angular and axial connection between the beam, the shells and the bushes.   - The invention is used for double-entry cylinder locks. <IMAGE>
Patent DE-69301032-D1 (DE)
Inventor: BORDIN ANGELO
IPC: C07C273/18
Filed: 1993-01-11
Granted: 1996-02-01
Abstract: A process for the purification of technical-grade N-alkyl urea, particularly mono-ethyl urea, including an alkali metal sulphate, characterised in that it includes the steps of:   treating the technical alkyl urea with a C1-C4 alcoholic solvent to cause the selective dissolution of the alkyl urea, separating the soluble fraction from the alkali metal sulphate which is insoluble in the alcoholic solvent, and removing the alcoholic solvent from the soluble fraction to recover the N-alkyl urea. e
Patent DE-69302796-D1 (DE)
Inventor: GUARNOTTA ALBERT
IPC: G08B15/00
Filed: 1993-11-22
Granted: 1996-06-27
Abstract: Tensioning device suitable for providing an adjustable, balanced tension to the power-supply and multiplexing cable (1) and to the coaxial video-transmission cable (2), these cables being connected to a camera turret supported by a carriage (C) for to-and-fro translational movement in a video surveillance tunnel, each of these two cables (1, 2) being anchored in a fixed manner to the carriage (C), as well as at its point (P1, P2) of penetration into the tunnel, coming from the outside of the latter, and being rigged over the pulley of a respective tensioning pulley block (M1, M2) before being anchored to the corresponding bracket (S1, S2) of the carriage (C), these two pulley blocks (M1, M2) being connected by a small flexible cable (3) passing over idler pulleys (4, 5, 7) and a tensioning-device roller (6). <IMAGE>
Patent DE-69321536-D1 (DE)
Inventor: VALYI EMERY I
IPC: B29C45/14
Filed: 1993-07-28
Granted: 1998-11-19
Abstract: A color coated article is formed by applying a color coated material to an injection mold (10) having mold halves (11,12), a mold cavity edge (15) and a mold cavity (14) therein for the formation of an injection molded article, and injecting molten plastic (30) into the mold cavity to form a laminated article (31) with the color coated material bonded to the injected plastic. The process uses a color coated blank (20) cut from a web and transfers the blank into registry with at least one of the mold halves (11). <IMAGE>
Patent DE-69332456-D1 (DE)
Inventor: MACRI JAMES N
IPC: G01N33/50
Filed: 1993-08-06
Granted: 2002-12-05
Abstract: The present invention relates to a method for detecting fetal Down syndrome (Trisomy 21), trisomy 13, trisomy 18 and other chromosomal anomalies during prenatal screening by analyzing blood samples from a pregnant woman. More particularly the present invention relates to a method for improving detection efficiency in screening for the anomalies by measuring the amount of the free beta human chorionic gonadotropin (HCG) and nicked or fragmented or aberrant forms of free beta (HCG), all of which are referenced throughout this application as free beta (HCG) in blood samples from pregnant women.
Patent DE-69334275-D1 (DE)
Inventor: CASTERMAN CECILE
IPC: C07K16/00
Filed: 1993-08-18
Granted: 2009-05-20
Abstract: The invention relates to an immunoglobulin  characterized in that  it comprises two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, this immunoglobulin being further devoid of light polypeptide chains.
Patent DE-69400469-D1 (DE)
Inventor: SESTELO JOSE P
IPC: C07C49/477
Filed: 1994-05-18
Granted: 1996-10-10
Abstract: The invention relates to a new vitamin D compound of the general formula <CHEM>  wherein: R2 is a (C1-C3)alkyl group, a hydroxy(C1-C3)alkyl group, a (C1-C2)alkoxymethyl group or a (C2-C3)alkenyl or alkynyl group; R3 is a branched or non-branched, saturated or unsaturated aliphatic 3- to 5-membered hydrocarbon or oxahydrocarbon biradical, having at least 3 atoms in the main chain and being optionally substituted with one or more substituents selected from epoxy, fluoro and hydroxy;     iPr is an isopropyl group; and     A and B are each individually hydrogen atoms or methyl groups, or     A and B form together a methylene group. The invention further relates to a method of preparing these compounds and to their use in pharmacotherapy and cosmetics. <IMAGE>
Patent DE-69406115-D1 (DE)
Inventor: REPINE JOHN E
IPC: C12Q1/32
Filed: 1994-03-18
Granted: 1997-11-13
Abstract: The present invention provides a method for assessing the risk of the development of adult respiratory distress syndrome (ARDS) in a septic patient comprising the steps of: determining a septic patient's serum level of lactate dehydrogenase (LDH) activity; and assessing the risk of the development of ARDS in said patient from said patient's serum level of LDH activity.