baber/WOPTO huggingface dataset:
Patent DE-69433161-T2 (DE)
Inventor: MCMURRY THOMAS BRIAN
IPC: A61K31/52
Filed: 1994-06-08
Granted: 2004-07-08
Abstract: O &cir& _<6>-hetarylalkyl- or naphthylalkylguanine derivatives of formula (I) wherein Y is H, ribosyl, deoxyribosyl, or R"XCHR"', wherein X is O or S, R'' and R''' are alkyl, or substituted derivatives thereof; R' is H, or alkyl or hydroxyalkyl; R is (i) a cyclic group having at least one 5- or 6-membered heterocyclic ring, optionally with a carbocyclic or heterocyclic ring fused thereto, the or each heterocyclic ring having at least one hereto atom chosen from O, N or S, or a substituted derivative thereof; or (ii) naphthyl or a substituted derivative thereof; and pharmaceutically acceptable salts thereof, exhibit the ability to deplete O &cir& _<6>-alkylguanine-DNA alkyltransferase (ATase) activity. A process for preparation of the compounds is described. The compounds have utility in combination with alkylating agents in the chemotherapeutic treatment of tumour cells.
Patent DE-69434181-T2 (DE)
Inventor: KIM SUN HYUK NEEDHAM MA
IPC: A61P1/12
Filed: 1994-08-08
Granted: 2005-12-01
Abstract: Peptide derivatives containing one or more substituents separately linked by an amide, amino or sulfonamide bond to an amino group on either the N-terminal end or side chain of a biologically active peptide moiety. The peptide derivatives have relatively enhanced biological activity when compared to the corresponding peptide alone.
Patent DE-69435027-T2 (DE)
Inventor: MARCOCCIA BRUNO S
IPC: D21C9/02
Filed: 1994-02-25
Granted: 2008-06-19
Abstract: A single vessel digester system for digesting cellulosic fibrous material comprises a substantially upright vessel (221) having a top (220) and bottom (222) with a slurry of comminuted cellulosic material to be digested introduced adjacent the top (220), and pulp withdrawn adjacent the bottom (222); the vessel having a continuous cooking zone disposed at a first level of said digester (221), and including a first screen (225) for removing liquor from the cooking zone and a cooking circulation loop (230, 235, 238, 239) associated with said first screen (225) for circulating removed liquor to the interior of said digester (221) near the vicinity of said first screen (225); and an extraction screen (245) with extraction conduit (246) located at a second vertical level in said vessel (221), below said first level, and having means for adding dilution liquid (241; 242), having a lower dissolved organic material concentration than the liquor removed in said cooking circulation loop (230, 235, 238, 239), to said cooking circulation loop (230, 235, 238, 239), to reduce the concentration of DOM in the digester and thereby increase the strength of the pulp so-produced.
Patent DE-69504646-T2 (DE)
Inventor: GRANGER VIVIAN
IPC: G01N33/50
Filed: 1995-04-05
Granted: 1999-04-29
Abstract: PCT No. PCT/EP95/01259 Sec. 371 Date Jan. 27, 1997 Sec. 102(e) Date Jan. 27, 1997 PCT Filed Apr. 5, 1995 PCT Pub. No. WO95/27203 PCT Pub. Date Oct. 12, 1995A stabilized cell suspension is prepared by treating the cell suspension with a solution of a heavy metal compound, which has been aged at pH 6.5-7.5 prior to use to allow a precipitate to form, removing the precipitate from the heavy metal solution, mixing the aged heavy metal solution with the cell suspension to form a first mixture, and mixing the first mixture with a paraformaldehyde solution to form a stabilized cell suspension which is still capable of lysis.
Patent DE-69506287-T2 (DE)
Inventor: NEWMAN THOMAS
IPC: C08F4/642
Filed: 1995-07-24
Granted: 1999-07-08
Abstract: A process for preparing syndiotactic polymers of vinylaromatic monomers comprising contacting one or more vinylaromatic monomers with a catalyst system comprising a pentamethylcyclopentadienyltitanium based metal complex capable of preparing syndiotactic vinylaromatic polymers under coordination polymerization conditions in the presence of hydrogen gas at a hydrogen partial pressure from 10 to 45 kPa and maintaining said partial pressure of hydrogen continuously throughout the polymerization.
Patent DE-69506881-T2 (DE)
Inventor: LEIKAUF BERNHARD
IPC: C04B28/02
Filed: 1995-08-07
Granted: 1999-06-02
Abstract: PCT No. PCT/EP95/03132 Sec. 371 Date Apr. 29, 1997 Sec. 102(e) Date Apr. 29, 1997 PCT Filed Aug. 7, 1995 PCT Pub. No. WO96/05150 PCT Pub. Date Feb. 22, 1996An accelerating admixture for use with sprayable cementitious compositions such as shotcrete comprises a mixture of (a) amorphous aluminium hydroxide and/or aluminium hydroxysulphate, and (b) at least one amine, preferably an alkanolamine. In a preferred embodiment, the admixture also comprises an aqueous dispersion of at least one polymer which comprises pendant carboxylic moieties.
Patent DE-69507743-T2 (DE)
Inventor: TONEL VALERIO
IPC: A63C17/02
Filed: 1995-05-26
Granted: 1999-06-10
Abstract: Roller skate with improved fit which includes a first front body (2) for supporting and securing the front part of the foot and a second rear body (8) for supporting and securing at least the heel. These bodies are rotatably associated with each other, and each body is provided with a supporting frame for at least one wheel. The articulation between the first body and the second body allows easier skating in improved comfort conditions. <IMAGE>
Patent DE-69510770-T2 (DE)
Inventor: JAERVENKYLAE JYRI
IPC: B29C57/00
Filed: 1995-04-03
Granted: 2000-02-10
Abstract: The invention relates to a pipe connection and a method for its manufacture. The ends of plastic pipes (1, 2) provided with a reinforcing layer (4) have an extension (5), the inside of which comprises a connecting piece (6), to which the extension is attached. It is possible to form a wide conical surface (9) to the end of the pipe despite the reinforcing layer, the connecting piece (6) being tightly attachable to this conical surface if this surface extends to the end of the pipe. <IMAGE>
Patent DE-69513202-T2 (DE)
Inventor: ACX KURT
IPC: C25D5/34
Filed: 1995-07-20
Granted: 2000-05-11
Abstract: A surface of copper foil is protected from oxidation and tarnishing by electrodepositing on the surface a protective layer containing metallic zinc and one or more compounds of trivalent chromium, which protective layer is easily removable by dissolution in a dilute aqueous alkaline solution and which preferably has a zinc to chromium weight ratio of 1:1 or greater. An electrodeposited copper foil especially suited for multilayer printed circuit boards has such a protective layer electrodeposited on the matte side thereof and an electrodeposited copper bonding treatment on the shiny side thereof.
Patent DE-69516266-T2 (DE)
Inventor: BRANDT GUNNAR
IPC: C04B35/119
Filed: 1995-01-19
Granted: 2001-01-25
Abstract: There is now provided an oxide based ceramic cutting insert for chipforming machining of heat resistant alloys comprising a ceramic oxide based matrix and 5-50% by volume of homogeneously dispersed whiskers of silicon carbide. The whiskers have an average length of 4-7  mu m, with substantially all of the whiskers having a length less than 10  mu m.
Patent DE-69516270-T2 (DE)
Inventor: LEE OCK
IPC: C21B11/00
Filed: 1995-12-28
Granted: 2000-12-21
Abstract: PCT No. PCT/KR95/00181 Sec. 371 Date Oct. 28, 1996 Sec. 102(e) Date Oct. 28, 1996 PCT Filed Dec. 28, 1995 PCT Pub. No. WO96/21044 PCT Pub. Date Jul. 11, 1996A three-stage, fluidized-bed-type reduction apparatus and a method for using it for reducing fine iron ores of wide size ranges, improving the gas utilization and reduction degree, reducing the residence time of iron ores, and increasing the prereduction rate of reduced iron. The apparatus includes serially arranged a drying/preheating furnace with a first cyclone connected to it, a primary prereduction furnace with a second cyclone connected to it, a secondary high-gas-velocity reduction furnace for finally reducing only a coarse ore portion of the prereduced iron ores at a bubbling fluidized state while carrying over the medium/fine ore portion of the iron ores, a secondary low-gas-velocity reduction furnace for finally reducing the medium/fine ores forming a bubbling fluidized bed thereof, an inner cyclone installed in the secondary low-gas-velocity reduction furnace, and a third cyclone for capturing dusty ores not captured by the inner cyclone.
Patent DE-69529614-T2 (DE)
Inventor: HEMMI KEIJI
IPC: A61P11/06
Filed: 1995-07-10
Granted: 2003-07-03
Abstract: Heterobicyclic derivatives of formula (I) wherein R<1> is aryl which may have suitable substituent(s), ar(lower)alkyl which may have suitable substituent(s), halo(lower)alkyl, protected carboxy(lower)alkyl, acyl(lower)alkyl, heterocyclic group or heterocyclic(lower)alkyl which may have suitable substituent(s), R<2> is aryl which may have suitable substituent(s) or heterocyclic group, and R<3> is hydrogen, lower alkoxy or arylthio, and a pharmaceutically acceptable salt thereof which are useful as PDE IV and TNF inhibitors for the treatment of hepatitis in human beings and animals. <CHEM>
Patent DE-69532109-T2 (DE)
Inventor: KHAN MOHAMMED ANJAM
IPC: C07K19/00
Filed: 1995-01-31
Granted: 2004-08-26
Abstract: The invention provides a DNA construct comprising the <u>htrA</u> promoter sequence operably linked to a DNA sequence encoding one or more heterologous proteins, replicable expression vectors containing the constructs, and attenuated bacteria containing the constructs or vectors. The invention also provides a vaccine composition comprising an attenuated bacterium as defined above, or a fusion protein expressed from a construct as defined above, and a pharmaceutically acceptable carrier.
Patent DE-69532162-T2 (DE)
Inventor: FAHEY KENNAN JOSEPH
IPC: A61P25/28
Filed: 1995-07-06
Granted: 2004-09-02
Abstract: This invention discloses methods of using certain aryl-benzo[b]thiophene and benzo[b]furan compounds to block or inhibit cannabinoid receptors in mammals. It also discloses novel compounds which are antagonists of the cannabinoid receptors and also discloses pharmaceutical formulations which contain the compounds as an active ingredient.
Patent DE-69607434-T2 (DE)
Inventor: VELDHUIS NICOLAAS
IPC: G10L25/75
Filed: 1996-03-18
Granted: 2000-09-14
Abstract: Speech synthesis is based on a human vocal chords model with two dynamically interlinked masses. Their positions determine glottis parameters. In particular, a first sub-model describes the dynamically interlinked masses acted upon by external forces. A second dynamical partial model describes dynamics of a contour of the glottis in dependence of geometry parameters produced by the first sub-model, and outputs a first part of the external forces in addition to transmitting the geometry parameters. A third hydrodynamic sub-model describes hydrodynamics in dependence of the transmitted parameters, is acted upon by air pressure parameters, and outputs a second part of the external forces and an actual volume velocity.
Patent DE-69614505-T2 (DE)
Inventor: WESSELTOFT PER
IPC: F24D13/02
Filed: 1996-01-12
Granted: 2001-11-22
Abstract: PCT No. PCT/NO96/00007 Sec. 371 Date Jul. 11, 1997 Sec. 102(e) Date Jul. 11, 1997 PCT Filed Jan. 12, 1996 PCT Pub. No. WO96/21828 PCT Pub. Date Jul. 18, 1996An electric heater for ceilings which emits radiant heat includes a radiant plate having heating elements which radiate in a downward direction. The radiant plate is mounted to a top part by a number of elastic/flexible brackets, including pivotable and non-pivotable brackets. The brackets allow the radiant plate to move laterally outward in a horizontal plane when the radiant plate is heated to prevent twisting or other deformation of the radiant plate. The pivotable brackets are mounted near the ends of the heater on all four sides to accommodate expansion of the radiant plate in a horizontal plane. The non-pivotable brackets are mounted at the midpoints of the ends of the heater.
Patent DE-69633895-T2 (DE)
Inventor: PINCHEN STEPHEN PAUL
IPC: C09J7/35
Filed: 1996-09-24
Granted: 2006-03-02
Abstract: Hermetically sealed packages for food, cigarettes and the like are formed from packaging material (37) having a tear tape (33) attached thereto. The tear tape includes a surface formed of a material (7) which flows under the conditions needed to seal portions (8,9) of the packaging material together when closing the package so as to fill any gaps between the tape and the packaging material portions. <IMAGE>
Patent DE-69636520-T2 (DE)
Inventor: CHU B
IPC: G01J5/08
Filed: 1996-10-18
Granted: 2008-01-03
Abstract: A portable data collection system is disclosed. The system includes a dataform reader module having a board camera electrically coupled to a control and decoder board in an open loop feedback configuration. The control and decoder board includes fuzzy logic image control circuitry which analyzes a captured frame of a video image including a dataform produced by the board camera. Based on the analysis of the captured frame, the fuzzy logic image control circuitry generates control signals to adjust operating parameters of the board camera such that an image suitable for decoding is produced.
Patent DE-69704022-T2 (DE)
Inventor: GARDON-MOLLARD CHRISTIAN
IPC: A61F5/00
Filed: 1997-05-29
Granted: 2001-05-23
Abstract: A compressive elastic-tights orthosis with an abdominal portion, or compressive knit, having a waist, front, back and, and groin, and adjoining two leg portions of compressive knit, the abdominal portion having a substantially triangular starched front region extending inward from the waist to the groin and having little deformability by providing high-pressure elasticity in both lateral and vertical directions, whereby, when the orthosis is worn, the front region exerts substantially constant pressure against the abdomen, in opposition to deformation of the abdomen, and the two leg portions exert vascular pressure on the lower limbs.
Patent DE-69708853-T2 (DE)
Inventor: PIISPANEN ARI
IPC: B23D15/04
Filed: 1997-01-16
Granted: 2002-08-01
Abstract: A cutting device for cutting a metal bar into thin plate-like pieces, said cutting device comprising a supporting frame (1), which supports the metal bar (9) to be cut, and a cutter plate (2) substantially transverse to the metal bar for carrying out the cutting, said cutter plate comprising a straight and planar inner surface (3) oriented in a direction parallel to the cutting face at the end of the metal bar, an outer surface (4) on the side facing towards the piece (16) to be cut off, and a cutter (5) connecting the inner and outer surfaces and provided with a cutting edge (6). The cutting edge (6) of the cutter (5) is at a distance from the plane determined by the inner surface (3) towards the outer surface (4), so that there is between the inner surface and the cutting edge a connecting surface (7) deviating from the direction of the inner surface.
Patent DE-69726541-T2 (DE)
Inventor: HAUSER KENNETH LEE
IPC: C07C59/68
Filed: 1997-10-09
Granted: 2004-09-30
Abstract: The present invention provides a class of compounds having the structure <CHEM> or a pharmaceutically acceptable salt where R<1> is hydrogen, hydroxy, alkoxy, alkoxycarbonyl, alkoxycarbonyloxy, aryloxycarbonyl, phenoxycarbonyloxy, or alkylsulfonyloxy; R<2> and R<3> are independently selected from hydrogen, halo, hydroxy, alkoxy, alkoxycarbonyl, alkoxycarbonyloxy, aryloxycarbonyl, phenoxycarbonyloxy, or alkylsulfonyloxy; R<4> is selected from hydroxy, alkoxy, cycloalklxy, 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidino, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, 1-hexamethyleneimino, and-OAr where where Ar is unsubstituted or substituted phenyl; X is selected from the group consisting of alkylene of two to four carbon atoms, -CH=CH-, -CH2CH=CH-, and -CH2CH2CH=CH-; and Y is absent or is carbonyl, with the proviso that when Y is absent, R<4> may not be hydroxy, alkoxy, cycloalkoxy or aryloxy. The compounds are selective estrogen receptor modulators (SERMÕs) and are useful in the treatment of pathological conditions associated with estrogen deprivation or the abnormal response to endogenous estrogen.
Patent DE-69736838-T2 (DE)
Inventor: MEREDITH MARK
IPC: C12N15/86
Filed: 1997-09-04
Granted: 2007-10-31
Abstract: The invention relates to herpesvirus saimiri viruses that are genetically modified by mutations and/or deleting specific essential and non-essential genes. The essential genes are required in replication of viral genes and are needed for viral proliferation. The non-essential genes can represent sites for the insertion of heterologous genetic material.
Patent DE-69801204-T2 (DE)
Inventor: MONTALI GIANLUIGI
IPC: B65B57/14
Filed: 1998-10-16
Granted: 2001-11-08
Abstract: A grouping station (100) receives rows (11) of plastic beakers (1) inserted one into another, coming from a rim making machine (2). The rows (11) of beakers (1) are subdivided into groups (10), that are moved to a packing station situated downstream thereof and including a main packing machine (30) and an additional packing machine (31). The grouping station (100) includes a rotary displacement device (5), that sends the rows (11) to a first counting-separating device (60) during regular operation. The first counting-separating device (60) is connected with the main packing machine (30). When a jam occurs, the rotary displacement device (5) sends the rows (11) to a second counting-separating device (80) that is connected with the additional packing machine (31). Each one of the counting-separating device (60,80) includes a disc (13) formed by adjacent sectors twisted along their radial axes like fan paddles. The disc separates from a row (11) a number of beakers necessary to form a predetermined group (10). <IMAGE>
Patent DE-69805199-T2 (DE)
Inventor: HORWITZ D
IPC: A01N1/02
Filed: 1998-02-06
Granted: 2002-12-12
Abstract: A method for the treatment of atherosclerosis and vascular injury using exochelins, and more particularly exochelins of Mycobacterium tuberculosis, to prevent vascular smooth muscle cell proliferation. Delivery of an effective amount of a desferri-Exochelins to a living organism such as an animal or a human by oral, intravenous or direct delivery to the site at which the effect is desired will protect blood vessels in a living organism from restenosis following angioplasty or vascular surgery and will prevent or slow the progression of atherosclerosis, systemic hypertension, radiation damage to the vasculature, stenosis or closure of bypass grafts to the coronary arteries or other blood vessels following a surgical procedure and various forms of pulmonary hypertension.
Patent DE-69817732-T2 (DE)
Inventor: JONES THOMAS RICHARD
IPC: C09D7/61
Filed: 1998-10-30
Granted: 2004-07-15
Abstract: A method of producing a porous inorganic particulate material which comprises treating a particulate aluminosilicate material with a leaching agent which chemically reacts with or solubilises aluminium and thereby leaches aluminium from the aluminosilicate material, wherein the particulate aluminosilicate material is a particulate hydrous aluminosilicate material which has been flash calcined. <IMAGE>
Patent DE-69828409-T2 (DE)
Inventor: HOBEL KLAUS
IPC: C09D175/04
Filed: 1998-08-21
Granted: 2005-12-01
Abstract: The invention pertains to a coating composition comprising a compound comprising at least one bicyclo-orthoester group and at least one other functional group. The invention also comprises a process for curing the present coating composition. Further, a process for making a bicyclo-orthoester-functional compound from the corresponding oxetane compound is described.
Patent DE-69831335-T2 (DE)
Inventor: SHELL JOHN
IPC: A61K9/20
Filed: 1998-06-05
Granted: 2006-06-08
Abstract: Drugs are formulated as unit oral dosage forms by incorporating them into polymeric matrices comprised of hydrophilic polymers that swell upon imbibition of water to a size that is large enough to promote retention of the dosage form in the stomach during the fed mode. The oral formulation is designed for gastric retention and controlled delivery of an incorporated drug into the gastric cavity, and thus administered, the drug is released from the matrix into the gastric fluid by solution diffusion. The swollen polymeric matrix, having achieved sufficient size, remains in the gastric cavity for several hours if administered while the patient is in the fed mode, and remains intact long enough for substantially all of the drug to be released before substantial dissolution of the matrix occurs. The swelling matrix lowers the accessibility of the gastric fluid to the drug and thereby reduces the drug release rate. This process, together with diffusion retardation by selection of specific polymers, polymer molecular weights, and other variables, results in a sustained and controlled delivery rate of the drug to the gastric cavity.
Patent DE-69831687-T2 (DE)
Inventor: RAJALA ANTTI
IPC: H04M11/08
Filed: 1998-10-13
Granted: 2006-07-06
Abstract: This invention relates to monitoring and maintaining a network in telecommunications networks which comprise a large number of network elements. These network elements are presented as a hierarchical diagram or as a map display on a graphical user interface. The graphical user interface presents performance information of the network element as a graphical presentation in connection with the network element symbol in such a way that the operator can, at one glance, identify the network elements that are the most important in terms of operation of the network or the network elements most affected by faults. In accordance with an embodiment of the invention, the alarm situation of each element is displayed as a graphical presentation along with the network element symbol on the graphical user interface simultaneously with the graphical presentation representing the performance. In this manner, fault management FM and performance management PM are connected, whereby a link is provided between the faults and their effects on the telecommunications network or the network element.
Patent DE-69902927-T2 (DE)
Inventor: NACHEV VALENTIN RASHEV
IPC: B23B31/12
Filed: 1999-05-25
Granted: 2003-05-28
Abstract: The present invention relates to a three-jaw tightening chuck, more particularly to a specific design of the gripping jaws, as well as to a method and a device for cutting teeth of the gripping jaws, that can be applied in machines operating with rotating tools. The method and the device can be used in manufacturing of tightening chucks.
Patent DE-69904496-T2 (DE)
Inventor: RICHTER BODO
IPC: C07F15/06
Filed: 1999-09-29
Granted: 2003-10-30
Abstract: A fluorous phosphine wherein the phosphor is coupled to at least one aryl or alkyl moiety, to which moiety a fluorous tail is coupled, wherein a spacer group, containing a non-carbon atom, is positioned between the aryl or alkyl moiety and the fluorous tail, a process for the preparation of said phosphines, metalcomplexes, catalysts and catalyst compounds therefrom and their use in catalysis.
Patent DE-69916112-T2 (DE)
Inventor: MENG JIAN
IPC: D04H1/46
Filed: 1999-10-26
Granted: 2005-02-17
Abstract: A fiber glass mat adapted to reinforce thermoplastic polymeric molding material is provided with improved flow properties in the molding process without sacrificing strength and without unduly increasing loft of the mat. The improvement is achieved by needling the mat from both sides with the number of needle punches per unit area on one side being greater than that on the opposite side.