Patent SG-11201805785T-A (SG)
Title: Chimeric proteins and methods of immunotherapy
Inventor: QI LEI S
IPC: C07K16/46
Filed: 2017-01-10
Abstract: extrarel ul r intraceilular 102 F GURE W O 20 17 / 12355 6 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/123556 Al 20 July 2017 (20.07.2017) WIPO I PCT (51) International Patent Classification: A61K 35/17 (2015.01) C07K 16/46 (2006.01) C07K 14/705 (2006.01) (21) International Application Number: PCT/US2017/012881 (22) International Filing Date: 10 January 2017 (10.01.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/277,322 11 January 2016 (11.01.2016) US 62/351,522 17 June 2016 (17.06.2016) US 62/399,902 26 September 2016 (26.09.2016) US 62/399,923 26 September 2016 (26.09.2016) US 62/399,939 26 September 2016 (26.09.2016) US (71) Applicant: THE BOARD OF TRUSTEES OF THE LE- LAND STANFORD JUNIOR UNIVERSITY [US/US]; Office of the General Counsel, Building 170, Third Floor, Main Quad, P.O. Box 20386, Stanford, California 94305- 2038 (US). (72) Inventors: QI, Lei S.; c/o The Board of Trustee of the Le- land Stanford Junior University, Office of the General Counsel, Building 170, Third Floor, Main Quad, P.O. Box 20386, Stanford, California 94305-2038 (US). WANG, Bing C.; 1505 Adams Drive, Suite D, Menlo Park, Califor- nia 94025 (US). (74) Agents: HAO, Joe C. et al.; Kilpatrick Townsend & Stockton LLP, Mailstop: IP Docketing - 22, 1100 Peachtree Street, Suite 2800, Atlanta, GA 30309 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, [Continued on next page] (54) Title: CHIMERIC PROTEINS AND METHODS OF IMMUNOTHERAPY 111111111111110111011111111111010111110111011111111011111111111111111111111111110111111 (57) : The present disclosure provides systems for immune cell regulation and methods of immuno - therapy. Systems of the present disclosure for immune cell regulation comprise a chimeric receptor poly- peptide, a chimeric adaptor polypeptide, a gene modu- lating polypeptide (GMP), and a cleavage moiety. WO 2017/123556 Al MIDEDIMOMOIDEIROIDEOMMOIllOMMOIMOVOIMIE GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))