baber/WOPTO huggingface dataset:
Patent FI-102175-B1 (FI)
Inventor: CLIFFE IAN ANTHONY
IPC: C07D295/10
Filed: 1990-04-20
Granted: 1998-10-30
Abstract: Piperazine derivatives of formula <CHEM> and their pharmaceutically acceptable acid addition salts are disclosed. In the formula n is 1 or 2, R is hydrogen or lower alkyl, R<1> is an aryl or nitrogen containing heteroaryl radical, R<2> is hydrogen or lower alkyl, R<3> is aryl, C4-8 alkyl or aryl(lower)alkyl and X is a functionalised group of specified meaning. The compounds exhibit activity as 5-HT1A antagonists and can be used, into alia, for the treatment of CNS disorders, such as anxiety.
Patent FI-101360-B1 (FI)
Inventor: SEUSTER EGON
IPC: B21K25/00
Filed: 1993-04-01
Granted: 1998-06-15
Abstract: The invention relates to a bimetallic blank for coins, medallions, tokens, gaming chips and the like, consisting of an inner disc (1) of a first metal or of a metal alloy which is pressed into the central aperture of an outer ring (2) of a second metal or of a second metal alloy, the disc (1) being provided with obliquely extending indentations (5) on its outer edge (4). <IMAGE>
Patent IE-35545-B1 (IE)
Title: A novel antibiotic and a process for its preparation
IPC: A23K20/195
Filed: 1971-08-13
Abstract: 1308843 Antibiotic X-5108 F HOFFMANN-LA ROCHE & CO AG 12 Aug 1971 [14 Aug 1970] 37925/71 Heading C2A The novel antibiotic X-5108, which is a yellow amorphous substance, soluble in alkanols, water-immiscible esters and chloroform, and insoluble in neutral water, forms salts with cations (e.g. Na, K and Ca), and may be identified by the following characteristics: analysis, C = 63À63%, H = 7À81%, N = 3À48% and O (by difference) = 25À08%; optical rotation of the Na salt [α]<SP>25</SP> D = -82À8 degrees (ethanol, C = 0À52); I.R. absorption spectrum as shown in Fig. 1, i.e. broad band at 3400 cm.<SP>-1</SP>, strong band at 1660 cm.<SP>-1</SP>, and prominent bands at 1580, 1380, 1250, 1100, 1040 and 995 cm.<SP>-1</SP>; U.V. absorption spectrum as shown in Fig. 3, having maxima as follows: in 0À1 N HCl, # max. 334 mÁ (E<SP>1%</SP> 1 cm. = 403), 233 mÁ (E<SP>1%</SP> 1 cm. = 610), and 206 mÁ (E<SP>1%</SP> 1 cm . = 500); in pH 7À0 buffer (isopropanol/K 2 HPO 4 ), #max 327 mÁ (E<SP>1%</SP> 1 cm . = 423) and 231 mÁ (E<SP>1%</SP> 1 cm. = 660); and in 0À1N KOH, #max 327 mÁ (E<SP>1</SP><SP>%</SP> 1 cm . = 416) and 231 mÁ (E<SP>1</SP><SP>%</SP> 1 cm. = 647); is prepared by cultivating Streptomyces sp. X-5108 (ATCC. 21386) or an antibiotic X-5108-producing mutant, subculture or variant thereof, under submerged aerobic conditions in an aqueous medium containing assimilable C and N sources and inorganic salts and recovering the antibiotic X-5108 from the culture medium. The antibiotic may be recovered by extraction (batchwise or by counter-current procedures) of the filtered medium with a waterimmiscible solvent therefor, e.g. butyl acetate, and purified by gel-permeation chromatography on crosslinked or polymerized dextran gel. It is isolated by treating an organic solvent solution of the purified antibiotic with diethyl sodium malonate to precipitate the antibiotic sodium salt, from which the free antibiotic may be obtained by treatment with aqueous acid e.g. NaH 2 PO 4 . A composition for enhancing the feed efficiency and stimulating the growth of poultry comprises antibiotic X-5108 or a physiologically acceptable salt thereof together with a non- toxic inert carrier ingredient and/or a nutrient feedstuff for poultry. The antibiotic has activity against Gram-positive and -negative bacteria, especially Streptococci, Pneumococci and other bacteria causing caecal coccidiosis.
[GB1308843A]
Patent IE-41294-B1 (IE)
Title: Spiroheterocyclic compounds and their use in pharmaceutical compositions
IPC: C07D335/04
Filed: 1975-06-12
Abstract: 1457222 Pharmaceutical spiroheterocyclic compounds ROUSSEL UCLAF 11 June 1975 [12 June 1974] 25044/75 Heading C2C Novel compounds of the formula wherein R and R<SP>1</SP> are hydrogen or (C 1 -C 4 ) alkyl, X is oxygen or sulphur and n is 2, 3 or 4 are prepared by reacting a compound of the formula or a functional derivative thereof, with a compound of the formula H 2 NOR<SP>1</SP>. The compounds of the invention possess pharmaceutical properties An example describes the preparation of N - methoxy - α - methyl - 2,3,5,6 - tetrahydro spiro(indane-1,4<SP>1</SP>-pyran)-5-acetamide.
[GB1457222A]
Patent IE-55460-B1 (IE)
Title: Triazole antifungal agents
IPC: C07D249/08
Filed: 1983-06-17
Abstract: Triazole antifungal agents of the formula:- 
<CHEM>
 and their O-esters and O-ethers;
 where R is naphthyl, biphenylyl or phenyl optionally substituted by 1 to 3 substituents each independently selected from halo, CF3, C1-C4 alkyl and C1-C4 alkoxy; and R<1> is
 -@NR<2>R<3>

 or -@R<3>

 where X is O or S;
 R<2> is hydrogen of C1-C4 alkyl; and
 R<3> is hydrogen, C1-C4 alkyl, C3-C6 cycloalkyl, aryl, aralkyl, or heteroaryl; or
 R<2> and R<3> taken together with the N atom to which they are attached represent a 1-pyrrolidinyl or piperidino group; and their pharmaceutically acceptable salts. The compounds are useful as human veterinary and agricultural fungicides.
Patent IE-70325-B1 (IE)
Title: Apparatus for detection of microorganisms
Inventor: DIGUISEPPI JAMES LAWRENCE
IPC: G01N21/51
Filed: 1990-05-07
Abstract: An instrument for monitoring the color change of an indicator element (2) sealed within a sterile vessel (1) and exhibiting a color change in response to a change in the pH or CO2 level within the sterile vessel (1) as a result of microbacterial growth within a specimen contained in the sterile vessel (1). The present invention includes means (6, 20) for continuously monitoring the absolute value of the pH and/or CO2 level within the vessel and/or monitoring the rate of change of the absolute value of the pH level.
Patent IE-43528-B1 (IE)
Title: Pyrido / 3,4-b / indole derivatives
IPC: C07D209/16
Filed: 1976-08-20
Abstract: 1502038 Pyrido[3,4 - b]indole derivatives ENDO LABORATORIES Inc 20 Aug 1976 [22 Aug 1975 22 June 1976] 34864/76 Heading C2C The invention comprises compounds of formula and their pharmaceutically suitable salts, wherein one of R 1 and R 3 is Me or Et and the other is H, Me or Et; and R 2 is H, C 1-3 alkyl, allyl or propargyl, provided that the total no. of C atoms in R 1 +R 2 +R 3 is #4. In examples, these compounds are prepared by reducing with BH 3 or NaBH 4 , followed by acid treatment, of the 4a,9a-dehydro analogues in which the 2- substituent is R 2 , MeCO or EtCO, or by hydrolysis of the corresponding 2-cyano compounds (for R 2 =H). Starting materials otherwise prepared are the corresponding 3,4 - dihydropyrido[3,4-b)indoles and their quaternary salts, 2-acyl analogues of the compounds of the invention, and compounds of formulae QCH:CRNO 2 , QCH 2 CHRNH 2 and QCH 2 CHRNHCOR1, where R is H, Me or Et, and R1 is Me or Et. Therapeutic compositions having antidepressant activity comprise compounds of the above formula and may be administered orally, parenterally or rectally.
Patent IE-43296-B1 (IE)
Title: Improvements in or relating to a holder for photographs or the like
IPC: A47G1/14
Filed: 1976-10-15
Abstract: 1513625 Picture holders DART INDUSTRIES Inc 10 Nov 1976 [12 Nov 1975] 46868/76 Heading A4X A holder for photographs or the like comprises spaced triangular-like end-walls (6), (7) between which extend walls (11), 13, 15, the walls (11), 13 being undercut at (131), (14), see Figs. 6 and 7 (not shown), to receive the opposite edges of a flexible sheet 17 which is flexed in a concave configuration towards the wall 15 whereby photographs or the like may be held in place between the sheet 17 and the wall 15. The sheet 17 is of plastics material, e.g. acrylic or polystyrene, and it may be clear throughout or have clear windows (19) framed by a darkened area (18). The windows (19) may be rectangular, square or oval. A second flexible plastics sheet may be provided, Figs. 10 to 12 (not shown), whereby photographs or dried flowers may be sandwiched between the sheets.
Patent IE-62943-B1 (IE)
Title: Apparatus for the delivery of substances process for the production thereof and use thereof
Inventor: JAEGER HALVOR DR
IPC: A61L15/16
Filed: 1988-08-22
Abstract: phe invention concerns a device for the release of substances made of hot-melt adhesives, with uniform or non-uniform distribution of the substances. The hot-melt adhesive has a processing temperature between 40 and 80 degrees Celsius, preferably between 40 and 60 degrees Celsius, and ideally between 40 and 55 degrees Celsius. Also described is a process for manufacturing the device in which the melted hot melt-adhesive containing the substances to be released is applied continuously or intermittently to a support at a hot-melt adhesive temperature between 40 and 80 degrees Celsius, preferably 40 and 60 degrees Celsius, and ideally 45 and 55 degrees Celsius, and in which, if necessary, a protective coating material is applied.
Patent IE-43753-B1 (IE)
Title: Packaging
IPC: B65D5/355
Filed: 1976-11-26
Abstract: A package of articles comprises a number of articles protectively enclosed by packaging. The package includes a supplemental blank which is formed so as to be capable of assembly into at least part of a supplemental carton of smaller volume than the volume of the package to receive part of the total number of articles of parts of the articles in the package when unpacked therefrom. The invention reduces waste of material and simplifies repacking.
Patent IE-57399-B1 (IE)
Title: Improved performance memory bus architecture
IPC: G06F13/16
Filed: 1985-11-04
Abstract: An improved performance memory bus architecture comprising a standard unified bus, microprocessor system, and separate memory bus. Access to memory banks coupled to the memory bus may be made by subsystems communicating over the unified bus using the standard protocol of the unified bus, or may be made by the microprocessor using an improved access protocol method wherein an accessed memory bank generates an acknowledgement signal upon receipt of a READ or WRITE command rather than after the completion of the respective READ or WRITE operation. A further improvement comprises an Early READ/WRITE circuit that rapidly detects the initiation of a READ or WRITE command by the microprocessor by decoding standard microprocessor status signals in order to generally commence a READ or WRITE operation prior to the time that a normal READ or WRITE operation would be commenced under the prior art.
Patent IE-60134-B1 (IE)
Title: Mechanical face seals
IPC: F16J15/34
Filed: 1987-10-14
Abstract: A rotary mechanical face seal includes first and second seal face members (10, 14), the sealing face (13) of one seal face member (14) being urged into engagement with the sealing face (16) of the other seal face member (10), said seal face members (10, 14) being such that when subjected to temperature gradients due to the generation of heat at the sealing faces (13, 16) the sealing faces (13, 16) will remain substantially parallel in spite of any thermal distortion of the seal face members (10, 14).
Patent IE-62721-B1 (IE)
Title: Lactide production from dehydration of aqueous lactic acid feed
Inventor: SINCLAIR RICHARD G
IPC: C07D319/12
Filed: 1991-09-17
Abstract: The present invention is directed to a method for making L-lactide from aqueous L-lactic acid. Aqueous lactic acid feed for present purposes comprehends an aqueous mixture of one or more of L1A, L2A, and L3A, optionally with LD being present. L-lactic acid is the preferred feed configuration for making L-lactide, and is to be understood even though the configuration symbol is not used throughout this application. Aqueous lactic acid feed is treated for removal of water therefrom until a degree of polymerization (DP) not substantially above about 2 is reached. The treatment then is ceased to produce a crude LD product. LD then is separated from the crude LD product. A preferred treatment involves heating the feed at elevated temperature to remove water. LD can be separated from the crude LD product by a variety of techniques to produce an LD-depleted product. This LD-depleted product, optionally augmented with additional aqueous lactic acid and/or water then can be readmitted to the process for making additional lactide. This cyclic or recycle process embodiment of the present invention enables very high lactide conversions to be realized.
Patent IE-60183-B1 (IE)
Title: Chromogenic acridinone enzyme substrates.
IPC: C12Q1/54
Filed: 1987-12-08
Abstract: Chromogenic acridinone enzyme substrate compounds comprising 7-hydroxy-9H-acridin-2-one chromogens derivatized at the 7-hydroxy-position with an enzymatically-cleavable group and disubstituted at the 9-position with alkyl or aryl groups, which can be the same or different, preferably lower alkyl or phenyl, respectively, or together form a cyclohexa-2,5-diene-4-one residue or a 4-hydroxycyclohexyl residue, and 7-hydroxy-1,3-dihalo-9,9-dimethyl-acridin-2-one intermediates useful for the preparation of the novel chromogenic acridinone enzyme substrate compounds and methods therefor. The enzymatically-cleavable group is a radical of a compound Y-OH comprising an enzyme-specific moiety which is capable of being cleaved by a specific enzyme wherein a deprotonated form of the chromogen is liberated having an absorbance maximum in basic solution which is substantially greater than the absorbance maximum of the chromogenic acridinone enzyme substrate compound to provide a distinct change in absorbance which can be accurately measured and correlated to the amount of enzyme present in a liquid test sample.
Patent IE-63929-B1 (IE)
Title: Method for the preparation of tetrahydrofolates
Inventor: MULLER HANS RUDOLF
IPC: C07D475/04
Filed: 1989-11-10
Abstract: The invention relates to a process for the separation of (6R,S)-folinates into their diastereomers, which comprises mixing an aqueous solution of a salt of (6R,S)-folinic acid with a water-soluble alkali metal, ammonium or alkaline earth metal salt of an inorganic or organic acid, removing the salt which separates out and which predominantly consists of the appropriate (6R)-folinate by filtration, and isolating the desired (6S)-folinate from the filtrate. …The process for the isolation of (6S)-folinate comprises causing the appropriate (6S)-folinate to separate out of the said filtrate by adding a water-miscible organic solvent and/or preferably a water- soluble alkaline earth metal salt, filtering it off and removing remaining (6R)-folinate by recrystallisation. …The separation off of alkaline earth metal salts of (6R)-folinic acid is preferably carried out at approximately neutral pH. …The alkali metal or alkaline earth metal salt of (6R,S)-folinic acid which is preferably used is the sodium, calcium or magnesium salt, the water-soluble alkali metal or ammonium salt of inorganic acids is preferably a sodium, potassium or ammonium halide, especially sodium iodide, sodium bromide, sodium chloride, potassium iodide, potassium bromide, potassium chloride, ammonium iodide, ammonium bromide or ammonium chloride, and the organic solvent for separating out the appropriate (6S)-folinate is a lower alcohol or a lower ketone, and the water-soluble alkaline earth metal salt is a calcium or magnesium halide. …The resulting (6S)-folinates are valuable medicaments for the treatment of megaloblastic folic acid deficiency anaemia, as antidote for enhancing the tolerability of folic acid antagonists, specifically of aminopterin, methotrexate and 5-fluorouracil in cancer therapy (leucovorin rescue) and the treatment of autoimmune diseases such as psoriasis and rheumatoid arthritis and for enhancing the tolerability of certain antiparasitics.
Patent IE-66000-B1 (IE)
Title: Hair conditioning shampoo compositionsw with silicone conditioning agent
Inventor: INMAN EVERETT JUNIOR
IPC: C11D1/82
Filed: 1992-04-03
Abstract: Disclosed are hair conditioning shampoo compositions, containing a detersive surfactant component, a silicone hair conditioning agent, and water and preferably comprising a suspending agent for the silicone conditioning agent. The detersive surfactant component comprises, at least in part, polyethylene glycol glyceryl fatty ester nonionic surfactant. The compositions hereof provide improved silicone deposition.
Patent LU-501907-B1 (LU)
Title: Arrangement mode of artificial fish reefs
Inventor: LIU HAIFEI
IPC: A01K61/70
Filed: 2022-04-22
Granted: 2022-10-24
Abstract: The disclosure relates to an arrangement mode of artificial fish reefs, and belongs to the technical field of fish breeding. The arrangement mode of the artificial fish reefs comprises fish reef blocks divided into two layers, each layer comprises four fish reef blocks sequentially arranged side by side, each layer of fish reef blocks are horizontally aligned, the two layers of fish reef blocks are vertically aligned, and the water flow direction is a sequential arrangement direction of each layer of the four fish reef blocks; and each fish reef block has a cubic frame. According to the invention, the adhesion quantity of fish eggs is increased.
Patent LU-503659-B1 (LU)
Title: Method for extracting luteolin from peanut shells
Inventor: CAO ZHONGYAN
IPC: C07D311/40
Filed: 2023-03-15
Granted: 2023-09-22
Abstract: The invention provides a method for extracting luteolin from peanut shells, which belongs to the technical field of compound extraction and comprises the following steps: (1) crushing and sieving peanut shells, adding petroleum ether for degreasing pretreatment, filtering and drying; (2) adding the dried peanut shells in step (1) into ethanol solution for extraction to obtain luteolin extract; (3) rotary evaporating the luteolin extract obtained in step (2) to obtain extract, and drying, pulverizing, washing and drying to obtain luteolin powder. The invention effectively solves the problems of waste of natural resources and environmental pollution caused by abundant peanut shell resources and low price, but less recycling. The extraction of luteolin from peanut shell has the advantages of simple operation, short process flow, high extraction rate, less impurities, low energy consumption, labor and time saving and convenience for industrial production.
Patent NO-308944-B1 (NO)
Inventor: DRIVER FRANKLIN THOMAS
IPC: F16L55/16
Filed: 1992-06-01
Abstract: In a tube eversion apparatus a first chamber in which the eversion pressure in developed is controllably sealed by a sphincter-type valve, the valve being in turn actuated by pressure developed in a preferably separately controllable and adjustable second chamber, another chamber preferably being provided above the sphincter-type valve for containing a supply of liquid and limiting turbulence from any escape of fluid past the sphincter-type valve, the other chamber also providing apparatus for supplying heated fluid to a lay-flat hose adapted to be pulled through the sphincter-type valve by the tube being [exerted] everted. Use of the improved apparatus involves appropriate modifications of the usual eversion process involving applying and controlling the everting pressure and the pressure exerted against the sphincter-type valve by the fluid in the second chamber.
Patent NO-300789-B1 (NO)
Inventor: LINDGREN PER-OLOF
IPC: B22F1/17
Filed: 1994-06-06
Abstract: PCT No. PCT/SE93/00808 Sec. 371 Date May 3, 1994 Sec. 102(e) Date May 3, 1994 PCT Filed Oct. 6, 1993 PCT Pub. No. WO94/08199 PCT Pub. Date Apr. 14, 1994.The invention relates to shot pellets for hunting wild game, particularly birds on wet marshlands. The pellets are also suitable for clay pigeon shooting on organized skeet ranges. The shot pellets have an inner core comprised of lead or lead alloy, and an outer layer of silver or silver alloy. The shot pellets are not influenced, or only slightly influenced by a strong hydrochloric acid environment, therewith greatly eliminating the risk of lead leaching from the pellets. The shot pellets are produced by coating shot pellet cores of lead or lead alloy electrochemically with at least one layer, wherein the outermost layer is always comprised of silver or a silver alloy.
Patent NO-308234-B1 (NO)
Inventor: GEBHARD-HANSEN KNUD ERIK
IPC: A61K9/113
Filed: 1995-03-08
Abstract: An antivirally active pharmaceutical oil-in-water emulsion containing 9-[(2-hydroxyethoxy)methyl]guanine (acyclovir) or a salt or ester thereof as an active ingredient in the continuous aqueous phase, said phase in addition to said active ingredient and the dispersed oil phase containing a water miscible organic solvent, wherein a polyhydric alcohol may form a constituent. The emulsion comprises from 1 % to 10 % w/w of acyclovir or a salt or ester thereof, from 20 % to 50 % w/w of organic solvent comprising from 5 % to 50 % w/w glycerol formal and from 0 % to 29 % w/w of a polyhydric alcohol, and from 20 % to 40 % w/w water, said percentages being based on the total weight of the formulation. As a polyhydric alcohol propylene glycol may be used, and the emulsion may be available as a cream, wherein the oil phase comprises white vaseline, liquid paraffin (paraffin oil), glycerol monostearate, and stearic acid.
Patent NO-317796-B1 (NO)
Inventor: DAVIES JOHN E
IPC: G01N33/50
Filed: 1995-07-14
Abstract: PCT No. PCT/CA94/00285 Sec. 371 Date Jul. 12, 1995 Sec. 102(e) Date Jul. 12, 1995 PCT Filed May 18, 1994 PCT Pub. No. WO94/26872 PCT Pub. Date Nov. 24, 1994A calcium phosphate based thin film on which bone cells may be cultured to permit evaluation of bone cell functional properties comprises calcium phosphate entities which provide for varying degrees of resorption of the calcium phosphate entities in evaluating the functional properties. The film is sufficiently thin that resorption of the entities can be detected. Such film, as applied to a support, is a very useful analytical component for evaluating such bone cell functional characteristics. An analytical device, which may be used in an analytical kit, can be provided having a plurality of wells with the devices located at the bottom thereof. A process is provided for making the film and especially the film which has a combination of calcium hydroxyapatite with tricalcium phosphate.
Patent NO-308773-B1 (NO)
Inventor: ERTEL KEITH DAVID
IPC: A61K31/445
Filed: 1996-04-24
Abstract: PCT No. PCT/US94/10972 Sec. 371 Date Jul. 3, 1996 Sec. 102(e) Date Jul. 3, 1996 PCT Filed Sep. 28, 1994 PCT Pub. No. WO95/11677 PCT Pub. Date May 4, 1995The present invention is directed to a chemically stable pharmaceutical composition containing ibuprofen in combination with terfenadine, wherein the oxidation of terfenadine to terfenadone is prevented by the presence in the composition of an  alpha -hydroxy carboxylic acid.
Patent NO-319182-B1 (NO)
Inventor: SHADLE PAULA JEAN
IPC: C07K16/00
Filed: 1996-08-21
Abstract: This invention relates to the application of hydrophobic interaction chromatography combination chromatography to the purification of antibody molecule proteins.
Patent NO-315411-B1 (NO)
Inventor: DUCHACZEK HUBERT
IPC: B01D53/14
Filed: 1996-10-04
Abstract: Described is a method of purifying oven exhaust gases in which oily organic substances based on mineral oils or natural oils are added to the exhaust-gas stream emerging from the oven and the temperature of the exhaust-gas stream is adjusted so that the oily organic substances do not burn or vapourize. The substances added are subsequently precipitated out together with the impurities originally present in the exhaust gases.