baber/WOPTO huggingface dataset:
Patent CA-3083953-A1 (CA)
Title: Dry adjuvanted immune stimulating compositions and use thereof for mucosal administration
Inventor: CUI ZHENGRONG
IPC: A61K9/18
Filed: 2018-12-11
Abstract: Described herein are dry immunogenic compositions and methods of freezing aluminum-containing vaccines such that when converted into a dried powder, the dry composition can be readily administered without loss of activity. Also described are methods of intranasal administering dry immunogenic compositions comprising antigens and aluminum adjuvants.
Patent CA-3086409-A1 (CA)
Title: Compositions and methods for inhibiting aldh2 expression
Inventor: SAXENA UTSAV
IPC: A61K31/712
Filed: 2019-01-15
Abstract: This disclosure relates to oligonucleotides, compositions and methods useful for reducing ALDH2 expression, particularly in hepatocytes. Disclosed oligonucleotides for the reduction of ALDH2 expression may be double-stranded or single-stranded, and may be modified for improved characteristics such as stronger resistance to nucleases and lower immunogenicity. Disclosed oligonucleotides for the reduction of ALDH2 expression may also include targeting ligands to target a particular cell or organ, such as the hepatocytes of the liver, and may be used to treat alcoholism and related conditions.
Patent CA-3087992-A1 (CA)
Title: Fluid control devices and methods of using the same
Inventor: SCHNUR JULIE A
IPC: F04B7/02
Filed: 2018-12-07
Abstract: A fluid control device includes an inlet configured to be placed in fluid communication with a bodily fluid source and an outlet configured to be placed in fluid communication with a fluid collection device. The fluid control device has sequestration portion that can be vented or evacuated. The fluid control device has a first state in which an initial volume of bodily fluid can flow from the inlet to the sequestration portion and a second state in which (1) the initial volume is sequestered in the sequestration portion, and (2) a subsequent volume of bodily fluid, being substantially free of contaminants, can flow through at least a portion of the fluid control device and into the fluid collection device. The fluid control device can transition automatically or in response to an actuation of a portion of the fluid control device after the sequestration portion receives the initial volume.
Patent CA-3088564-A1 (CA)
Inventor: LU MIN
IPC: A61P35/00
Filed: 2019-01-02
Abstract: Novel mp53 rescue compounds and the pharmaceutical composition, and methods of treating a p53 disorder.
Patent CA-3091469-A1 (CA)
Inventor: COSSAIRT TRAVIS JON
IPC: A63F13/213
Filed: 2018-11-06
Abstract: An interactive video game system includes an array of volumetric sensors disposed around a play area and configured to collect respective volumetric data for each of a plurality of players. The system includes a controller communicatively coupled to the array of volumetric sensors. The controller is configured to: receive, from the array of volumetric sensors, respective volumetric data of each of the plurality of players; to combine the respective volumetric data of each of the plurality of players to generate at least one respective model for each of the plurality of players; to generate a respective virtual representation for each player of the plurality of players based, at least in part, on the generated at least one respective model of each player of the plurality of players; and to present the generated respective virtual representation of each player of the plurality of players in a virtual environment.
Patent CA-3091993-A1 (CA)
Inventor: SHELTON PERNILLE TOFTENG
IPC: C07K14/47
Filed: 2019-02-26
Abstract: Compstatin analogues having improved binding and complement-inhibiting activity as compared to the 13 amino acid compstatin peptide (ICVVQDWGHHRCT (cyclic C2-C12)) are described, in particular compstatin analogues that additionally possess useful physicochemical properties, such as increased solubility. These analogues include variants with an isoleucine residue at position 3 in place of the wild type valine residue,which provides compstatin peptides with improved binding and complement-inhibiting activity and also enables the introduction of other modifications, for example modifications that are capable of increasing solubility, such as the introduction of charged or polar amino acids at position 9 and/or the introduction of N-and/or C-terminal sequences.
Patent CA-3092585-A1 (CA)
Title: Parenterally administered immune enhancing drugs
Inventor: JAEN JUAN CARLOS
IPC: C07H19/23
Filed: 2019-03-08
Abstract: Methods of identifying compounds that modulate the conversion of AMP to adenosine by 5'-nucleotidase, ecto, and that possess particular pharmacokinetic characteristics are described herein. Methods of such compounds, and compositions comprising same, for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, are also provided.
Patent CA-3093946-A1 (CA)
Inventor: LEDINEK GREGOR
IPC: B27M1/00
Filed: 2020-09-14
Abstract: An automatic machine for width gluing of wooden lamellas into laminated plates of optional dimensions according to the invention consists of a press and a glue application device and enables fast continuous gluing of wooden lamellas of optional lengths, widths and thicknesses into laminated plates also of optional dimensions. The press is characterized by a modular construction, which consists of innovative supporting framework segments with intermediate work modules in a sequential string, which together enable transport of wooden lamellas, their pressing and gluing in the same plane within the entire construction of the press. Each work module consists of a work table assembly, a pressure shoes assembly and a segment pushers assembly. Within these assemblies, innovative constructions of segment pushers, long pressure shoes and short pressure shoes are characteristic.
Patent CA-3094027-A1 (CA)
Title: Genes, constructs and maize event dp-202216-6
Inventor: CHRISTENSEN HEATHER MARIE
IPC: A01H5/00
Filed: 2019-04-16
Abstract: The compositions and methods disclosed relate to DNA compositions, plant cells, seeds, plant parts that relate to maize plants with increased grain yield trait. Also provided are assays for detecting the presence of the maize DP-202216-6 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.
Patent CA-3097319-A1 (CA)
Inventor: KOREN LITAL
IPC: A01N43/647
Filed: 2019-05-08
Abstract: The present invention relates to the use of cyclodextrins for increasing biological activity and improving retention and/or bioavailability of agrochemicals such as pesticides.
Patent CA-3100213-A1 (CA)
Title: Cassettes d'expression d'alpha-glucosidase acide optimisees par des codons et leurs methodes d'utilisation
Inventor: ANGUELA XAVIER
IPC: C07K16/44
Filed: 2019-05-15
Abstract: L'invention concerne des acides nucléiques codant pour l'a-glucosidase acide (GAA). Dans certains modes de réalisation, les acides nucléiques présentent une identité de séquence supérieure à environ 86 % par rapport à une séquence choisie dans le groupe constitué par l'une quelconque des séquences telles que décrites dans les SEQ ID NOs : 1 à 5. Dans certains modes de réalisation, les acides nucléiques codant pour l'a-glucosidase acide (GAA) contiennent moins de 127 dinucléotides CpG. L'invention concerne également des cassettes d'expression, des vecteurs, des cellules et des lignées cellulaires et des méthodes d'utilisation de tels acides nucléiques codant pour l'a-glucosidase acide (GAA).
Patent CA-3100358-A1 (CA)
Title: Activite antitumorale in vitro et de xenogreffe d'un xanthene halogene contre des tumeurs solides pediatriques refractaires
Inventor: SINGER JAMIE
IPC: A61K45/06
Filed: 2019-05-15
Abstract: L'invention concerne une méthode de traitement d'une tumeur solide cancéreuse pédiatrique chez un sujet mammifère, qui comprend l'administration par voie intra-lésionnelle d'une quantité d'un xanthène halogéné ou d'un sel pharmaceutiquement acceptable de celui-ci, de préférence le sel disodique de Rose Bengale, qui provoque l'ablation de cellules tumorales de la tumeur administrée. Une autre méthode envisagée comprend les étapes consistant à administrer par voie intra-lésionnelle une quantité d'un xanthène halogéné ou d'un sel pharmaceutiquement acceptable de celui-ci, de préférence le sel disodique de Rose Bengale, qui provoque l'ablation de cellules tumorales de la tumeur administrée, et à administrer de manière systémique une quantité efficace inhibitrice de tumeur d'un médicament anticancéreux à action systémique qui fournit une cytotoxicité synergique avec le xanthène halogéné. Les deux administrations peuvent se produire simultanément, ou l'une avant l'autre.
Patent CA-3100494-A1 (CA)
Inventor: CHAUDHURI RAJA
IPC: A63B21/055
Filed: 2019-04-09
Abstract: L'invention concerne un système d'entraînement par résistance. Le système d'entraînement comprend un mouflage fournissant un avantage mécanique, et un utilisateur réalise des exercices d'entraînement à la force en tirant ou en poussant sur le bloc de course tout en résistant au mouvement du bloc de course en tirant ou en poussant sur l'extrémité libre de l'appareil de course.
Patent CA-3104158-A1 (CA)
Inventor: BRICKLEY STEPHEN C
IPC: B01D53/14
Filed: 2019-07-01
Abstract: A rotary sorption bed system includes a rotating sorbent mass of a regenerable sorbent material, in a cycle of operation, a given volume of the sorbent mass sequentially passing through first, second, third, fourth, and fifth zones, before returning to the first zone; a process fluid stream directed through the first zone; a regeneration fluid stream directed through the third zone; and an isolation fluid stream that recirculates in a closed loop independent of the process fluid stream and the regeneration fluid stream through the second and fourth zones. The regeneration fluid stream passes through the fifth zone before passing through the third zone.
Patent CA-3105739-A1 (CA)
Title: Stockage elastique en nuage sur emplacements multiples
Inventor: ZHANG JUN
IPC: H04L29/08
Filed: 2019-07-19
Abstract: L'invention concerne, dans des modes de réalisation décrits, des systèmes et des procédés de gestion du stockage de données d'un utilisateur à travers des fournisseurs de services de stockage. Un service de stockage peut recevoir une demande de stockage de données par un utilisateur. Le service de stockage peut communiquer avec des fournisseurs de services de stockage et peut entretenir des vecteurs de stockage pour chaque fournisseur de services de stockage. Le service de stockage peut identifier une politique pour l'utilisateur. La politique peut spécifier une utilisation des fournisseurs de services de stockage d'après un profil d'utilisateur. Le service de stockage peut déterminer, d'après la politique, des fournisseurs de services de stockage à utiliser pour les données de l'utilisateur. Le service de stockage peut stocker une première partie des données dans un premier vecteur de stockage d'un premier fournisseur de services de stockage. Le service de stockage peut stocker une seconde partie des données soit dans un second vecteur de stockage d'un second fournisseur de services de stockage, soit dans un stockage du service de stockage.
Patent CA-3107066-A1 (CA)
Inventor: SCHMALRIEDE TOBIAS
IPC: B60R1/076
Filed: 2019-07-31
Abstract: The invention relates to a retaining device (10) for an exterior add-on part (12) of a motor vehicle, comprising a main part (16) for arrangement on the outside of the motor vehicle, on which main part a connection element (24) is mounted by means of a first pivoting device (26), by means of which the connection element (24) can be pivoted relative to the main part (16) about a first pivot axis (32) between a working position and at least one protection position and which has a first spring device, by means of the spring force of which the connection element (24) can be returned from the at least one protection position into the working position. A retaining element (30) is provided for the exterior add-on part (12), which retaining element is mounted on the connection element (24) by means of a second pivoting device (28) having a second spring device, such that the retaining element can be pivoted about a second pivot axis (34) between the working position and the at least one protection position, which second pivot axis is spaced apart from the first pivot axis (32) and parallel thereto. The retaining element (30) can be returned from the at least one protection position into the working position by means of the second spring device.
Patent CA-3107409-A1 (CA)
Inventor: TAKAHASHI YOSHIMASA
IPC: A61P31/16
Filed: 2019-07-22
Abstract: The present invention provides a composition containing a universal influenza vaccine antigen and a vaccine adjuvant.
Patent CA-3111460-A1 (CA)
Inventor: DUQUE ANA LATORRE
IPC: A61M3/02
Filed: 2019-10-02
Abstract: The present invention relates to an enema device comprising a delivery container arranged for accommodating an enema and an applicator nozzle for dispersing the enema, and wherein the delivery container is arranged as a hand held pump and wherein a cross-section of said delivery container has the shape of an oval. Thereby is provided a simple, inexpensive and essentially maintenance free enema device which can be used for self- administrating of an enema.
Patent CA-3112503-A1 (CA)
Title: Modified wood product
Inventor: ELS JUSTIN
IPC: B27K3/02
Filed: 2019-09-12
Abstract: A method of producing a modified wood product is disclosed. The method comprises heating a resin impregnated wood product in a reactor, the resin impregnated wood product comprising source wood impregnated with a resin composition comprising resin, the heating being so as to substantially cure the resin, thereby to produce the modified wood product. The method comprises, during the heating of the resin impregnated wood product in the reactor, introducing water into the reactor. A reactor and a modified wood product are also disclosed.
Patent CA-3112678-A1 (CA)
Inventor: WANG JU-MING
IPC: G01N33/577
Filed: 2019-09-13
Abstract: La présente invention concerne un anticorps monoclonal PTX3 ou un fragment Fab de l'anticorps et une utilisation associée. Ledit anticorps monoclonal ou fragment Fab de l'anticorps susmentionné inhibe ou ralentit de manière spécifique la liaison de PTX3 au récepteur PTX3, et peut être utilisé pour un kit et un procédé de détection de PTX3, et une composition pharmaceutique qui inhibe ou ralentit des maladies ou des symptômes associés à la liaison à PTX3 et au récepteur PTX3, ainsi qu'une utilisation associée.
Patent CA-3113618-A1 (CA)
Inventor: WITTRUP KARL DANE
IPC: C07K14/78
Filed: 2019-07-26
Abstract: The present disclosure provides immunomodulatory fusion proteins comprising a collagen-binding domain operably linked to an immunomodulatory domain. The disclosure also features compositions and methods of using the same, for example, to treat cancer.
Patent CA-3115615-A1 (CA)
Title: Stabilized antibody-containing liquid formulations
Inventor: IGAWA TOMOYUKI
IPC: A61K39/395
Filed: 2011-01-20
Abstract: Disclosed is an antibody-containing solution preparation which does not undergo the production of conjugates when stored for a long period, is stable, and is suitable for subcutaneous administration. It is found that the use of a histidine buffer or aspartic acid or glutamic acid (which is an acidic amino acid) as a counter ion species for tris(hydroxymethyl)aminomethane, i.e., the use of a histidine-aspartate buffer or a histidine-glutamate buffer as a buffer or a tris(hydroxymethyl)aminomethane- aspartate or a tris(hydroxymethyl)aminomethane-glutamate exhibits a significant stabilizing effect. It is also found that the use of aspartic acid or glutamic acid (which is an acidic amino acid) as a counter ion species for a basic amino acid (e.g., arginine), i.e., the use of an arginine- aspartate or an arginine-glutamate exhibits a significant stabilizing effect.
Patent CA-3117692-A1 (CA)
Title: Panneau de revetement exterieur formant barriere a l'eau
Inventor: DONELAN JEFFREY W
IPC: B32B13/12
Filed: 2019-10-31
Abstract: L'invention concerne un panneau de revêtement extérieur à base de ciment, qui empêche la pénétration de l'eau et la fuite d'air. L'invention concerne également des procédés de fabrication de panneaux de revêtement extérieur à base de ciment comportant une feuille formant barrière à l'air/l'eau intégrée hautement efficace. L'invention concerne également un système de revêtement extérieur faisant appel audit panneau de revêtement extérieur à base de ciment.
Patent CA-3119353-A1 (CA)
Title: Unite de serrure a barillet et cle associee
Inventor: WIDEN BO
IPC: E05B27/00
Filed: 2018-12-07
Abstract: Unité de serrure à barillet pourvue d'une fiche de clé rotative (300) et d'une liaison pour transférer un couple à un mécanisme de serrure lorsqu'une fiche de clé est mise en rotation. L'unité de serrure à barillet comprend un logement (200) présentant une partie supérieure (220), dotée d'une rangée centrale de goupilles de verrouillage dans des cavités associées, et une partie inférieure (240) dotée d'un trou cylindrique recevant la fiche de clé rotative. Une région arrière (LI) de la fiche de clé a une longueur minimale d'au moins 50 % de la longueur totale de celle-ci. La région avant (FR1) adjacente a une longueur maximale de 50 % de la longueur totale et reçoit, en plus de la rangée centrale de goupilles de verrouillage, au moins un mécanisme de serrure latéral (351a, 351b, 351c) qui est situé dans sa totalité à l'intérieur de la région avant de la fiche de clé et interagit avec la partie inférieure du logement. L'invention concerne également une clé (40) de déverrouillage de l'unité de serrure.
Patent CA-3119355-A1 (CA)
Title: Microfluidic device with programmable switching elements
Inventor: BREINLINGER KEITH J
IPC: B03C5/02
Filed: 2019-11-18
Abstract: Microfluidic devices having a circuit substrate with a control unit, a switching mechanism associated with a dielectrophoresis (DEP) electrode, and a memory unit are described. Switching instructions may be received, stored, and retrieved by the control unit and used to control the DEP electrode via the switching mechanism. Systems comprising the described microfluidic devices and methods of controlling the described microfluidic devices are included herein.
Patent CA-3119815-A1 (CA)
Title: Portable hand sanitizing system in a fanny pack
Inventor: BORDELEAU SIMON
IPC: A45F5/00
Filed: 2021-05-27
Abstract: A fanny pack or small pack that has at least one but preferably two or more pockets made out of an absorbent lining material capable of holding a quantity of a sanitizing substance imbibed therein.
Patent CA-3126238-A1 (CA)
Inventor: HOCKING GRANT
IPC: A61B5/024
Filed: 2020-01-16
Abstract: Disclosed herein are in vivo non-invasive methods and devices for the measurement of the hemodynamic parameters, such as blood pressure, cardiac output, stroke volume and vascular tone, of a subject, and the mechanical anelastic in vivo properties of the subject's arterial blood vessels. An exemplary method requires obtaining the peripheral pulse volume waveform (PVW), the peripheral pulse pressure waveform (PPW), and the peripheral pulse velocity waveform (PUW) from the same artery; calculating the time phase shift between the PPW and PVW, and the plot of pulse pressure versus pulse volume: and determining the blood pressures and power law components of the anelastic model from the waveforms PPW and PVW, the cardiac output from the waveforms PPW and PUW, and the quality factor of the artery based upon the calculations. The disclosed methods and devices can be used to diagnose and treat cardiovascular disease in a subject in need thereof.
Patent CA-3128265-A1 (CA)
Inventor: YUAN FANG
IPC: H04W28/22
Filed: 2019-01-31
Abstract: Embodiments of the present disclosure provide methods, devices and computer readable media for multi-TRP communication. In a method for communication, a terminal device receives control information from at least one of a first network device and a second network device. The terminal device determines, from the control information, a first parameter for communication of a first data between the first network device and the terminal device and a second parameter for communication of a second data between the second network device and the terminal device, and the first data and the second data are identical. The terminal device performs, based on the first and second parameters, the communication of the first data with the first network device and the communication of the second data with the second network device. The embodiments of the present disclosure propose a new design of control information for multi-TRP communication.
Patent CA-3128338-A1 (CA)
Title: Smart device for promoting products on a shelf
Inventor: VLAD CLUVE MIRCEA IOAN
IPC: G09F27/00
Filed: 2020-01-31
Abstract: The invention refers to a smart device for the promotion of shelf products which are exhibited in supermarkets, pharmacies, gas stations, DIY stores, etc. through sound, motion, light and smell when a consumer passes next to the shelf, used in advertising, marketing. The smart device for promoting products on a shelf is characterized in that it consists of a motion transmission system (T) installed in a box (1), a modular universal gripping system (32) made of metal or plastic, an integrated electronic circuit board (35) based on a microprocessor installed in the box (1) on which control and command components are installed; an electronically controlled magnet lamp (24), an electronically controlled smell dispenser (28), the lamp (24) and the dispenser (28) being installed outside the box (1); an audio system (A) consisting of a loudspeaker (34) installed inside the box (1) and an audio amplifier (37) installed on the electronic board (35); a motion sensor (29) detecting the consumer, and communication means (C) installed on the electronic board (35) for bidirectional transmission/reception of the commands on the type of motion, the type and frequency of illumination, smell dispenser operating interval, the device's operating hours, the customized transmission of the audio/light message according to the consumer's characteristics, reports on the traffic in front of the shelf where the device is installed, and the number of interactions with the consumer, this information being uploaded on the web platform and sent as a report to the customers.
Patent CA-3128725-A1 (CA)
Inventor: LAZAROVICH MARK
IPC: A61K9/00
Filed: 2020-01-30
Abstract: A system for inducing a Pavlovian association of a scent with a state of less-than-moderate pain, to thereby minimize perceived pain, and to reduce the need for narcotic analgesics. The system includes at least a physiological sensor configured to detect at least one physiological parameter of the user. The physiological parameter of the user may include heart rate variability, blood pressure, galvanic skin response, movement, facial expression and the like. After detection of the physiological parameter, an activation signal is then transmitted to an automatically activated scent diffuser, which diffuses a scent, as a function of the electronic activation signal. Activation of the scent diffuser is maintained by a control circuit that receives the detection signal from the at least one physiological sensor, ascertains that the user has transitioned to a state of less-than-moderate pain, and transmits a signal to the automatically activated scent diffuser.