baber/WOPTO huggingface dataset:
Patent WO-2020009945-A1 (WO)
Title: Mild and site-selective 18f-labeling of small molecules and/or biomolecules via a thiol-reactive synthon
Inventor: MURPHY JENNIFER M
IPC: C07D233/70
Filed: 2019-06-28
Abstract: Site-selective conjugation to biomolecules via thiol-based chemistry is superior to the unselective modification of lysine residues, which produce a mixed product and can potentially interfere with binding affinity of the biomolecule. However, in physiological environments, the maleimide-thiol conjugation product which is the current gold-standard for site-selective thiol-conjugation can be susceptible to hydrolysis or a retro-Michael reaction via exchange with reactive thiols such as those in albumin or glutathione residues yet the degradation is relatively slow. Therefore, for  in vivo  studies, the maleimide-thiol conjugation proposes instability issues. The compositions and methods disclosed herein provide an alternative thiol-based linkage, one that overcomes the instability issues with conventional reagents and methods. The compositions and methods disclosed herein are useful in various contexts, for example, for  18 F-labeling of peptides/proteins in the preparation of positron emission tomography (PET) probes.
Patent WO-2020018521-A1 (WO)
Title: Method of providing wired pipe drill services
Inventor: MACPHERSON JOHN
IPC: E21B17/02
Filed: 2019-07-16
Abstract: A method of providing wired pipe drill services to an oil field operational participant includes providing a durable drilling component to the oil field operational participant, providing the durable element including receiving a sale payment from the oil field operational participant. The method can include either or both of providing a plurality short life wired pipe drilling components to the oil field operational participant, providing the short life wired pipe drilling components including receiving a rental fee from the oil field operational participant, wherein the rental fee includes an operation cost portion that is based on a data rate to be used by the short life wired pipe drilling components and providing a software product to the oil field operational participant, the software product allowing for the reception of data from at least one of the short life wired pipe drilling components.
Patent WO-2020023433-A1 (WO)
Title: System for ascertaining fresh water consumption by a dishwasher
Inventor: LEHMANN SVEN
IPC: A47L15/00
Filed: 2019-07-23
Abstract: A system for ascertaining fresh water consumption by an, in particular, commercial dishwasher (1) or a component thereof. The system includes a container (12, 22) for temporarily storing liquids, wherein the container (12, 22) has a liquid inlet (25), which can be flow-connected to a fresh water source if required, and a liquid outlet (23), which can be flow-connected to a freshwater consuming means, in particular a freshwater consuming means of the dishwasher (1), if required. The system further comprises at least one pressure sensor (B3, B4) for detecting an, in particular, hydrostatic pressure in the container (12, 22), and an evaluation device which is designed to ascertain a fresh water volume flow into the container (12, 22) depending on at least one output value of the at least one pressure sensor (B3, B4).
Patent WO-2020023510-A1 (WO)
Title: Belt clamp
Inventor: BROWN LESLEE
IPC: F16G3/08
Filed: 2019-07-23
Abstract: A clamp comprising a first member, a second member connectable to the first member and comprising a second surface having a first groove and a second groove, each groove for receiving a toothed belt tooth, a peak is disposed between each groove, the second member cooperatively engages the first member to engage the toothed belt there between, and the first member comprising at least one arcuate concave surface extending across a clamp width, the arcuate concave surface corresponding with the second member peak when the second member is fastened to the first member.
Patent WO-2020033159-A1 (WO)
Title: Pressure balancing mechanism for a connector
Inventor: LEVY DAVID
IPC: F16L19/06
Filed: 2019-07-25
Abstract: A pressure balancing apparatus can have a compression collar to mate with a component comprising a seal, and a gripper to anchor to a tube and the compression collar. The compression collar is used to apply an axial force to the tube to relieve shear stress on proximate seals. The method can include mating a compression collar to a component comprising a seal, anchoring a gripper to a tube, mating the gripper to the compression collar, and using the compression collar to apply an axial force to the tube.
Patent WO-2020055622-A1 (WO)
Title: Thermal boundary control
Inventor: SPRAFKE THOMAS P
IPC: H05K1/03
Filed: 2019-09-03
Abstract: A method of creating thermal boundaries in a substrate is provided. The method includes forming the substrate with first and second sections to be in direct thermal communication with first and second thermal elements, respectively, machining, in the substrate, first and second cavities for defining a third section of the substrate between the first and second sections and disposing a material having a characteristic thermal conductivity that is substantially less than that of the ceramic in the first and second cavities.
Patent WO-2021045745-A1 (WO)
Title: Non-intrusive automated deposition management
Inventor: BENNETT DAVID
IPC: E21B37/06
Filed: 2019-09-04
Abstract: A method may include: generating a signal in a conduit; measuring the signal; generating data representing a deposit in the conduit, the data being generated by a deposition identification model, wherein the deposition identification model utilizes the signal as an input; generating a treatment plan based at least in part on the data representing the deposit; and applying a chemical additive to the conduit based at least in part on the treatment plan.
Patent WO-2021045775-A1 (WO)
Title: Controlling speed of cooling elements
Inventor: CHANG HUNG-WEN
IPC: G06F1/20
Filed: 2019-09-06
Abstract: Examples of devices and methods for controlling speed of cooling elements are discussed. The device comprises a first temperature reader to measure an ambient temperature in the vicinity of the device. The device further comprises a processor to control a speed of a cooling element of the device based on a comparison of the ambient temperature with a first threshold temperature.
Patent WO-2020112215-A1 (WO)
Title: Material flow amplifier
Inventor: SCHMIDT PAUL
IPC: B01F23/47
Filed: 2019-09-17
Abstract: Material flow amplifiers as disclosed herein overcome drawbacks associated with known adverse flow conditions (e.g., surface erosion and head losses) that arise from flow of certain types of materials (e.g., fluids, slurries, particulates, flowable aggregate, and the like) through a material flow conduit. Such material flow amplifiers provide for flow of flowable material within a flow passage of a material flow conduit (e.g., a portion of a pipeline, tubing or the like) to have a cyclonic flow (i.e., vortex or swirling) profile. Advantageously, the cyclonic flow profile centralizes flow toward the central portion of the flow passage, thereby reducing magnitude of laminar flow. Such cyclonic flow profile provides a variety of other advantages as compared to a parabolic flow profile (e.g., increased flow rate, reduce inner pipeline wear, more uniform inner pipe wear, reduction in energy consumption, reduced or eliminated slugging and the like).
Patent WO-2020068831-A1 (WO)
Title: Dynamic graph representation learning via attention networks
Inventor: SANKAR ARAVIND
IPC: G06N20/00
Filed: 2019-09-24
Abstract: A method includes extracting, by an analysis computer, a plurality of first datasets from a plurality of graph snapshots using a structural self-attention module. The analysis computer can then extract at least a second dataset from the plurality of first datasets using a temporal self-attention module across the plurality of graph snapshots. The analysis computer can then perform graph context prediction with at least the second dataset.
Patent WO-2020069369-A1 (WO)
Inventor: VENKATARAMANI RAHUL
IPC: G06N3/04
Filed: 2019-09-27
Abstract: L'invention concerne un système qui se prête à un apprentissage permanent dans un contexte d'apprentissage profond. Le système comprend un réseau d'apprentissage profond conçu pour traiter un ensemble de données d'entrée et accomplir une ou plusieurs tâches parmi un premier ensemble de tâches. Par exemple, le réseau d'apprentissage profond peut faire partie d'un système d'imagerie, tel qu'un système d'imagerie médicale, ou peut être utilisé dans des applications industrielles. Le système comprend en outre une unité d'apprentissage couplée en communication au réseau d'apprentissage profond (102) et conçue pour modifier le réseau d'apprentissage profond de façon à lui permettre d'accomplir une ou plusieurs tâches dans une seconde liste de tâches sans perdre la capacité d'accomplir les tâches figurant sur la première liste.
Patent WO-2020081950-A1 (WO)
Title: User equipment cooperative multipoint reception and transmission
Inventor: DAMNJANOVIC ALEKSANDAR
IPC: H04W40/24
Filed: 2019-10-18
Abstract: Methods, systems, and devices for wireless communication are described. Generally, the described techniques performed at a user equipment (UE) provide for communicating directly with a base station using a first set of antennas and communicating indirectly with the base station (e.g., via a wireless node, a remote radio head, etc.) using a second set of antennas to fully exploit the potential capabilities of the physical antennas at the UE. For downlink communications, a UE may receive at least a subset of downlink signals from a base station via a wireless node, and, for uplink communications, the UE may transmit at least a subset of uplink signals to the base station via a wireless node. To facilitate these techniques, the UE may configure the wireless node to forward downlink signals received from the base station to the UE or to forward uplink signals received from the UE to the base station.
Patent WO-2020097533-A1 (WO)
Title: Digital fiat currency
Inventor: HURRY SIMON J
IPC: G06Q20/06
Filed: 2019-11-08
Abstract: Techniques are disclosed which include receiving, by a central entity computer, a request for digital currency. The request includes a serial number and a denomination of a physical currency. The central entity computer generates the digital currency for the denomination and linked to the serial number. The generating includes recording the digital currency on a blockchain. The central entity computer transmits a notification of the generation of the digital currency. The central entity computer causes removal of the physical currency from circulation in a fiat currency system.
Patent WO-2021107946-A1 (WO)
Title: Compositions orales
Inventor: ARNOLD MICHAEL
IPC: A61K9/68
Filed: 2019-11-27
Abstract: Composition à mâcher pour le blanchiment des dents comprenant une première région et une seconde région séparées par une couche barrière ; la première région comprenant du peroxyde de carbamide ayant une teneur en eau d'environ 2 % ou moins, un agent mouillant (par exemple, de la glycérine), une base de gomme à mâcher anhydre ayant une teneur en eau d'environ 1 % ou moins, un acide de fruit anhydre, et un ou plusieurs additifs de gomme ; et la seconde région comprenant une composition à mâcher comprenant une base de gomme, une source d'ion bicarbonate et un ou plusieurs additifs de gomme. L'invention concerne également un kit comprenant des compositions à mâcher séparées correspondant aux première et seconde régions, et des procédés de blanchiment des dents à l'aide de la composition à mâcher.
Patent WO-2020118252-A1 (WO)
Inventor: WARNER STEVEN L
IPC: C12Q1/68
Filed: 2019-12-06
Abstract: Methods of treating castration-resistant and castrati on- sensitive prostate cancer using a compound having the following structure (I): or a pharmaceutically acceptable salt or zwitterionic form thereof, are provided.
Patent WO-2021118517-A1 (WO)
Inventor: CUMBIE MICHAEL
IPC: G01N35/00
Filed: 2019-12-09
Abstract: In one example an apparatus can include a controller communicatively coupled to a droplet dispenser to deposit fluid on a digital microfluidic (DMF) array including a plurality of droplet manipulation electrodes, the controller to: select a first droplet manipulation electrode from the plurality of droplet manipulation electrodes to on which to dispense a first volume of fluid via the droplet dispenser; position the droplet dispenser over the selected first droplet manipulation electrode; and deposit the first volume of fluid onto the selected first droplet manipulation electrode.
Patent WO-2020149960-A1 (WO)
Title: Recherche d'images numériques complémentaires à l'aide d'un réseau antagoniste génératif conditionnel
Inventor: GUPTA MITHUN DAS
IPC: G06V10/75
Filed: 2019-12-10
Abstract: L'invention concerne une technique mise en œuvre par ordinateur pour récupérer au moins une image de sortie recommandée. Dans un mode de réalisation, la technique utilise un composant générateur pour transformer des informations d'image de première partie, associées à une image de première partie sélectionnée par un utilisateur, en une ou plusieurs instances d'informations d'image générées de seconde partie. Chaque instance des informations d'image générées de seconde partie complète les informations d'image de première partie. Le composant générateur est entraîné par un système d'entraînement mis en œuvre par ordinateur à l'aide d'un réseau antagoniste génératif conditionnel (cGAN). La technique comprend en outre : la récupération d'une ou de plusieurs images de sortie de seconde partie à partir d'une mémoire de données sur la base de l'instance ou des instances d'informations d'image générées de seconde partie ; la génération d'une présentation d'interface utilisateur qui présente l'image de première partie et l'image ou les images de sortie de seconde partie ; et l'affichage de la présentation d'interface utilisateur sur un dispositif d'affichage. Dans un exemple, l'image de première partie et les images de sortie de seconde partie présentent des éléments d'habillage complémentaires.
Patent WO-2020131572-A1 (WO)
Title: Détection d'accès non autorisé à une boîte verrouillée
Inventor: LINGALA RAMESH
IPC: E05B19/00
Filed: 2019-12-12
Abstract: L'invention concerne la détection d'un accès non autorisé d'une boîte à clés verrouillée ayant une clé pour un véhicule ou un local. Une indication est reçue au niveau d'un capteur couplé à la clé indiquant que la boîte à clés a été fracturée. Une notification est envoyée en réponse à la réception de l'indication selon laquelle la boîte à clés a été fracturée.
Patent WO-2020131574-A1 (WO)
Title: Method of reducing aromatic nitro compounds
Inventor: BISAGNI SERENA
IPC: C12P13/00
Filed: 2019-12-12
Abstract: A method for reducing a substrate selected from 2-methyl-5-nitropyridine and methyl 4-(2-fluoro-3-nitrobenzyl)piperazine-1-carboxylate is provided catalysed by a nitroreductase and a disproportionation agent.
Patent WO-2020131580-A1 (WO)
Title: Détection de geste acoustique en vue de la commande d'un dispositif d'écoute
Inventor: KIM LAE-HOON
IPC: H04R1/10
Filed: 2019-12-12
Abstract: L'invention concerne des procédés, des systèmes, des supports lisibles par ordinateur et des appareils destinés à la commande de geste. Un exemple comprend l'indication, sur la base d'informations provenant d'un premier signal d'entrée audio, de la présence d'un objet à proximité d'un microphone, et l'augmentation d'un niveau de volume en réponse à l'indication.
Patent WO-2020124073-A1 (WO)
Inventor: LUDERER HILARY
IPC: G16H50/20
Filed: 2019-12-16
Abstract: L'invention concerne un système comportant un matériel de traitement de données et un matériel de mémoire en communication avec le matériel de traitement de données, le matériel de mémoire stockant des instructions qui, lorsqu'elles sont exécutées sur le matériel de traitement de données, entraînent l'exécution par le matériel de traitement de données d'opérations comprenant l'exécution d'une thérapie numérique de prescription configurée pour traiter des symptômes d'un trouble lié à l'utilisation d'opioïdes chez un patient, l'exécution de l'agent thérapeutique numérique de prescription comprenant la réception d'une pluralité d'entrées associées au patient à partir d'un ou de plusieurs parmi des (i) premiers capteurs associés directement au patient et (ii) des seconds capteurs associés à un dispositif électronique de patient, la pluralité d'entrées représentant un niveau de sevrage aux opioïdes associé au patient, la pondération de la pluralité d'entrées associées au patient pour fournir une pluralité d'entrées pondérées, la détermination d'un dosage recommandé d'un produit contenant de la buprénorphine pour le patient sur la base de la pluralité d'entrées pondérées, et l'instruction d'une unité d'administration pour administrer le dosage recommandé du produit contenant de la buprénorphine au patient.
Patent WO-2020150362-A1 (WO)
Title: Biosynthèse enzymatique de lactones
Inventor: SCHIRMER ANDREAS W
IPC: C12N15/52
Filed: 2020-01-15
Abstract: L'invention concerne des procédés de production de lactones naturelles par des bactéries dans des conditions physiologiques. Les procédés utilisent des protéines ybgC ayant une activité de lactonisation.
Patent WO-2020150391-A1 (WO)
Title: Construction de cellules souches modifiées et leurs utilisations
Inventor: BEARD CLAYTON
IPC: C12N15/85
Filed: 2020-01-15
Abstract: L'invention, selon certains modes de réalisation, concerne des polynucléotides recombinants qui codent pour un ligand inducteur apoptotique une fois soumis à un premier signal d'initiation de traduction, et un facteur de transdifférenciation et un polypeptide anticancer une fois soumis à un second signal d'initiation de traduction. L'invention, selon certains autres modes de réalisation, concerne également une cellule souche modifiée qui comprend le polynucléotide recombinant et des méthodes de génération de la cellule souche modifiée. L'invention, selon encore d'autres modes de réalisation, concerne des méthodes d'utilisation de la cellule souche modifiée en tant que thérapeutique en présence d'un cancer.
Patent WO-2021154216-A1 (WO)
Title: Fusion proteins and methods of treating complement dysregulation using the same
Inventor: CHANDLER JULIAN
IPC: C07K14/00
Filed: 2020-01-28
Abstract: Described herein are fusion proteins that include two fragments of factor H, a fragment of factor H and an Fc domain, or a fragment of factor H, a fragment of CR2, and an Fc domain. The use of such proteins in methods of treatment for diseases mediated by alternative complement pathway dysregulation.
Patent WO-2020172607-A1 (WO)
Inventor: BIHORAC AZRA
IPC: G16H50/20
Filed: 2020-02-21
Abstract: Methods, apparatus, systems, and computer program products for providing patient predictions are provided in various embodiments. Responsive to receiving an indication of initiation of a patient interaction, a model for the patient is initiated by an assessment computing entity. The model has been trained using machine learning and the model is configured to generate a prediction for the patient. The prediction comprises at least one of an acuity score or a mortality prediction. Responsive to identifying a prediction trigger, the assessment computing entity updates the model for the patient based at least in part on medical data corresponding to the patient. The assessment computing entity generates the prediction using the updated model. The assessment computing entity provides at least a portion of the prediction such that the at least a portion of the prediction may be used to update an electronic health record corresponding to the patient and/or provided to a clinician for review.
Patent WO-2020172640-A1 (WO)
Title: Contraceptifs unisexes non hormonaux
Inventor: LISHKO POLINA V
IPC: C07C235/64
Filed: 2020-02-21
Abstract: La présente invention concerne des produits, des compositions, et des formulations contraceptifs unisexes non hormonauxs ainsi que des méthodes d'utilisation, qui comprennent une quantité efficace d'un non-coupleur de mitochondries légères ciblées.
Patent WO-2020226737-A1 (WO)
Title: Bipolar all-memristor circuit for in-memory computing
Inventor: YI WEI
IPC: G06N3/063
Filed: 2020-03-06
Abstract: A circuit for performing energy-efficient and high-throughput multiply-accumulate (MAC) arithmetic dot-product operations and convolution computations includes a two dimensional crossbar array comprising a plurality of row inputs and at least one column having a plurality of column circuits, wherein each respective column circuit comprises: an excitatory memristor neuron circuit having an input coupled to a respective row input; a first synapse circuit coupled to an output of the excitatory memristor neuron circuit; an inhibitory memristor neuron circuit having an input coupled to the respective row input; and a second synapse circuit coupled to an output of the inhibitory memristor neuron circuit, and an output memristor neuroncircuit coupled to the first output and second output of each column circuit.
Patent WO-2020190783-A1 (WO)
Title: Turbomolecular pump and cathode assembly for etching reactor
Inventor: LILL THORSTEN
IPC: H01L21/687
Filed: 2020-03-13
Abstract: A processing chamber and method of etching a semiconductor substrate are presented. The processing chamber is symmetric, with the centerlines of a chuck and stem of a stage to retain a semiconductor substrate aligned with a centerline of a passage in a core of a pump used to evacuate the processing chamber and with a centerline of a gas port through which gas is introduced to the processing chamber. The stem extends through the passage and a spiral groove is formed in the passage in only one of the stem or an inner surface of the core to provide pumping action to counter back streaming of the gas from an exhaust of the pump in an intermediate and viscous flow regime inside a gap between the stem and the core.
Patent WO-2020190900-A1 (WO)
Title: Abiraterone-cyclic oligomer pharmaceutical formulations and methods of formation and administration thereof
Inventor: MILLER DAVE
IPC: A61K47/40
Filed: 2020-03-17
Abstract: The present disclosure relates to pharmaceutical formulations including abiraterone and a cyclic oligomer, as well as tablets including such pharmaceutical formulations, methods of forming such pharmaceutical formulations, and methods of administering such pharmaceutical formulations or tablets.
Patent WO-2020160564-A1 (WO)
Title: Preferred path routing in ethernet networks
Inventor: BRYANT STEWART
IPC: H04L45/02
Filed: 2020-03-18
Abstract: The disclosure relates to creating a data path using a link state protocol. A node in an Ethernet network receives a link state message that includes preferred path routing (PPR) description information. The PPR description information includes a path identifier (ID) and a plurality of sequentially ordered topological path description elements (PDEs). A next hop node is determined using the next topological PDE in the plurality of sequentially ordered topological PDEs listed in the PPR description information, and the PPR description information is stored by the node and used to forward data in the Ethernet network.