baber/WOPTO huggingface dataset:
Patent DE-10207682-C5 (DE)
Title: Dichtungsanordnung zum Abdichten einer Tür gegenüber der Karosserie eines Kraftfahrzeugs
Inventor: KULKA THOMAS
IPC: B60J10/79
Filed: 2002-02-22
Granted: 2008-08-28
Abstract: Dichtungsanordnung
zum Abdichten einer Tür
gegenüber
der Karosserie (60) eines Kraftfahrzeugs mit  einem aus einem
elastomeren Werkstoff gefertigten Dichtungsprofil (10), das umfasst:  einen
an einem Flansch (50) der Tür
festlegbaren Befestigungsabschnitt (20), der aus einem ersten elastomeren Werkstoff
gefertigt ist;  einen ersten, bei geschlossener Tür an der
Karosserie (60) anliegenden Dichtungsabschnitt (30) und  einen
zweiten, eine in der Tür
angeordnete Fensterscheibe (55) abdichtenden Dichtungsabschnitt
(40), der auf der dem ersten Dichtungsabschnitt (30) gegenüberliegenden Seite
des Befestigungsabschnitts (20) angeordnet und aus einem zweiten
elastomeren Werkstoff gefertigt ist;  wobei der erste Dichtungsabschnitt
(30) mit wenigstens einer Dichtlippe (31) versehen ist;  wobei
die Dichtlippe (31) ein Zugspannungen aufnehmendes Spannband (33)
umfasst,  das eine der Karosserie (60) zugewandte Wandung einer allseitig
von Teilen des Dichtungsprofils (10) umschlossenen Hohlkammer (34)
bildet;  wobei das Spannband (33) aus Zellgummi oder Moosgummi
gefertigt ist;   wobei die Dichtlippe (31) einen...
Patent DE-10262106-C5 (DE)
Title: Leucit-Glaskeramik-Pulver
Inventor: CONRAD THOMAS
IPC: A61K6/06
Filed: 2002-12-30
Granted: 2011-03-31
Abstract: Dotiertes Leucit-Glaskeramik-Pulver, zur Herstellung einer Glaskeramik, welche aus dem Gerüstsilikat Leucit gebildet wird, umfassend  (a) ein Leucit-Glaskeramik-Pulver; und  (b) ein nanoskaliges Metalloxid-Pulver mit einem d 50 -Wert von 1 nm bis 200 nm,  wobei das nanoskalige Metalloxid in einer Menge von 60 Gew.-% bis 80 Gew.-% des dotierten Leucit-Glaskeramik-Pulvers vorliegt  und wobei das Leucit-Glaskeramik-Pulver ferner folgende Zusammensetzung aufweist:                SiO 2     70 Gew.-% (bezogen auf das Gesamtgewicht der Leucit-Glaskeramik-Pulvers (a));      Al 2 O 3     10 Gew.-%;      K 2 O   10 Gew.-%;      Na 2 O   5 Gew.-%;      CaO   2 Gew.-%;      BaO   1 Gew.-%;      CeO 2     1 Gew.-%;      B 2 O 3  und TiO 2     1 Gew.-%.
Patent DE-102005059888-C5 (DE)
Inventor: KABATZKE WOLFGANG DR ING
IPC: F03D7/02
Filed: 2005-12-15
Granted: 2016-03-10
Abstract: The blades are controlled by changing their momentum when operated in a partial load mode and by changing their pitch under full load. For obtaining an optimal effect the unit is operated using a predetermined characteristic curve family. In a first section a torque control under partial load is performed up to a first predetermined speed of rotation and in a second section from the first to a second. Under full load the pitch is changed in relation to the speed level in a third and fourth section. In a fifth section the momentum is changed according to changes in the fourth section.
Patent DE-102008053068-C5 (DE)
Title: Freikolbenmotor mit variablem Hub, Verfahren zum Betreiben eines Freikolbenmotors und Verwendung von Öffnungen in einer Kolbenaufnahme
Inventor: GRÄF MARKUS DR
IPC: F02B71/00
Filed: 2008-10-24
Granted: 2023-11-23
Abstract: Freikolbenmotor (10) mit variablem Hub, aufweisend einen Kolben (12) und eine Kolbenaufnahme (14) mit einer Seitenwand (16), entlang derer sich der Kolben (12) linear verlagern kann, und mit einer ersten Öffnung (22) und einer zweiten Öffnung (24), die dafür ausgebildet sind, eine Zufuhr von Brennstoffgemisch (34) in einen Expansionsraum (40) und eine Abfuhr von Abgas (32) aus dem Expansionsraum (40) zu ermöglichen, wobei an der Seitenwand (16) mindestens eine weitere, dritte Öffnung (36) dafür ausgebildet ist, eine Zufuhr von Brennstoffgemisch (34) oder eine Abfuhr von Abgas (32) zu ermöglichen, wobei die dritte Öffnung (36) höchstens 50% eines maximalen Hubs (74) des Kolbens (12) vom unteren Totpunkt (72) bei maximalem Hub (74) entfernt angeordnet ist und in den Expansionsraum (40) mündet, und wobei die erste Öffnung (22) an einer Stirnwand (20) der Kolbenaufnähme (14) angeordnet ist.
Patent DE-102015111312-C5 (DE)
Title: Verfahren und Vorrichtung zum Herstellen einer Bürste
Inventor: BOUCHERIE BART GERARD
IPC: A46D3/04
Filed: 2015-07-13
Granted: 2020-06-25
Abstract: Verfahren zum Herstellen einer Bürste, die einen Borstenträger (10) aus thermoplastischem Kunststoff mit zumindest einer Verankerungsöffnung (12), in welche zumindest eine Borste aus thermoplastischem Kunststoff eingesetzt und darin ankerlos verankert wird, aufweist, gekennzeichnet durch folgende Schritte:die wenigstens eine Borste wird in eine Aufnahmeöffnung (26) eines Werkzeugteils aufgenommen,die wenigstens eine Borste wird mit ihrem Befestigungsende, während sie noch in der Aufnahmeöffnung (26) sitzt, in eine beim Herstellen des Borstenträgers (10) gebildete Verankerungsöffnung (12) im Borstenträger (10) geschoben, ohne darin befestigt zu sein,das Werkzeugteil wird aufgeheizt, sodass die dem Borstenträger (10) gegenüberliegende Stirnseite (22) des Werkzeugteils auf eine Temperatur gebracht wird, die unterhalb der Schmelztemperatur des Borstenmaterials und/oder des Borstenträgermaterials liegt, insbesondere höchstens 85 % in °C der jeweiligen Schmelztemperatur des Borsten- und/oder des Borstenträgermaterials beträgt,das Werkzeugteil wird relativ zum Borstenträger (10) bewegt, sodass das Werkzeugteil den Borstenträger (10) kontaktiert und ihn aufheizt,das Werkzeugteil übt eine Druckkraft auf den Borstenträger (10) aus und verformt den Borstenträger (10) zumindest im Bereich des die Verankerungsöffnung (12) umgebenden Randes unter Reduzierung des Querschnittes der Verankerungsöffnung (12) derart, dass die zumindest eine Borste in die Verankerungsöffnung (12) eingebettet und verankert ist, unddas Werkzeugteil wird relativ zum Borstenträger (10) weg bewegt, sodass die zumindest eine Borste aus der Aufnahmeöffnung (26) gezogen wird.
Patent BR-PI0713580-C8 (BR)
Title: composição de revestimento cúravel com radiação actínica, processo de formação de um revestimento sobre um substrato, e, estojo de partes para a preparação de uma composição de revestimento curável com radiação actínica
Inventor: EDITH BENNINGSHOF-HULSBOS
IPC: C08G18/42
Filed: 2007-06-20
Abstract: composição de revestimento curável com radiação actínica. a presente invenção refere-se a uma composição de revestimento curável com radiação actínica compreendendo um composto tendo pelo menos dois grupos isocianato, um composto tendo pelo menos dois grupos hidroxila e um catalisador fotolatente para a reação de adição de isocianato-hidroxila, onde o catalisador tofolatente é um composto de metal orgânico compreendendo um metal cataliticamente ativo latente, e em que o átomo de metal caraliticamente ativo latente no composto de metal orgânico não tem quaisquer ligações com outros átomos de metal. a invenção refere-se ainda a um processo para formação de um revestimento sobre um substrato.
Patent RU-2289146-C9 (RU)
Inventor: UFAEV VLADIMIR ANATOL EVICH
IPC: G01S5/04
Filed: 2005-02-21
Granted: 2007-01-20
Abstract: FIELD: radio engineering, in particular, radio direction finding. 
     SUBSTANCE: radio signals are received with the aid of omnidirectional aerials forming an N-element aerial array, complex amplitudes of radio signals are measured at the outputs of the aerials, they are transformed to a first-order angular spectrum, the values and co-ordinates of the square maximum of its modulus are determined, the mean power of the complex amplitudes of radio signals in total of the aerials is determined, the first-order angular spectrum with due account made for the co-ordinates of its maximum is transformed to the second-order angular spectrum, the co-ordinates and the values of the square maximum of its modulus are determined, the value of the square maximum of the modulus of the first-order angular spectrum is normalized to the mean power, the number of radio signals and the angles of their incoming are judged according to the results of normalization and the co-ordinates of the maxima.  The normalized values of the maxima of the squares of the angular spectra modi are summed up and compared with the first threshold, if it is not exceeded the absence of radio signals is determined, otherwise, the relationship between the result of subtraction of the sum of the values of the squares of the angular spectra modi from unity and the result of subtraction of the value of the maximum square of the first-order angular spectrum modulus from unity, the obtained relationship is compared with the second threshold, if it is exceeded, the presence of one radio signal is fixed, otherwise - of two radio signals.  The values of the thresholds are determined according to the Neumann - Pearson's criterion proceeding from the preset probability of false alarm, quantity, mutual location of the aerials, radiation wavelength and the preset error of direction finding. 
     EFFECT: enhanced efficiency of detection and direction finding at reception of radio signals of two sources of radio emission, as well as at an unknown dispersion of noise of the receiving channels. 
     4 dwg
Patent DK-138191-D0 (DK)
Inventor: MINNINGER KONRAD
IPC: A61K47/10
Filed: 1991-07-23
Abstract: A preparation containing salicylic acid for topical treatment of desquamative skin diseases in the field of human and veterinary medicine contains 1 to 15 wt.% of salicylic acid, 1 to 15 wt.% of an aliphatic 1,2-diol and 70 to 98 wt.% of an ester of a mono- or polyhydric alcohol, in particular propan-1,2-diol or glycerin, and at least one fatty acid, chosen from the group of saturated, medium-chain fatty acids and saturated, long-chain, branched fatty acids, where the quantities are expressed as percentages of the total weight of the preparation.
Patent DK-157790-D0 (DK)
Inventor: ZACHARIAS FRIEDEMANN
IPC: F16M3/00
Filed: 1990-06-29
Abstract: The invention relates to a combination power and heat unit with a bedplate (1), flanged-together machines (2, 3), a noise suppressor (8), an exhaust-gas heat exchanger (9), a cooling-water heat exchanger (19) as well as the associated auxiliary apparatus and piping, wherein the bedplate (1) shelters the noise suppressor (8) and the exhaust-gas heat exchanger (9) along its opposite longitudinal sides below the machines (2, 3), which are elastically supported on the bedplate (1). So that the bedplate will not impair the design of the devices, which are to be arranged in optimally accessible fashion, and will be suitable for various devices, it is provided that the bedplate (1) is open to the sides and exhibits a horizontal frame (6) supporting the machines (2, 3), which frame rests on a plurality of braces (7) arranged along the longitudinal axis of the bedplate (1), which braces are substantially x-shaped in the direction transverse to the longitudinal axis of the bedplate (1) and are arranged on the interior side between the noise suppressor (8) and the exhaust-gas heat exchanger (9).
Patent DK-175385-D0 (DK)
Inventor: KONRATH JOHN
IPC: G01N33/50
Filed: 1985-04-18
Abstract: A method for the preparation of microscope slides for immunocytochemical procedures is disclosed. The slides comprise cell or tissue specimens adhered onto polylysine-treated slides. The specimens on the slides are preserved by applying a fixative and a water-soluble overcoating, so that the slides can be easily produces and stored.
Patent DK-189388-D0 (DK)
Inventor: BREIPOHL GERHARD
IPC: C07C217/54
Filed: 1988-04-07
Abstract: Novel compounds of the formula 
<IMAGE>
 in which R<1> denotes (C1-C8)-alkyl or optionally substituted (C6-C14)-aryl, R<2> denotes hydrogen or an amino acid radical which is protected by an amino protective group which can be removed by a weak acid or base, R<3> denotes hydrogen or (C1-C4)-alkyl and Y<1>-Y<9> denote identical or different radicals of hydrogen, (C1-C4)-alkyl, (C1-C4)-alkoxy or -O-(CH2)n-COOH, (with n = 1 to 6), where one of these radicals is -O-(CH2)n-COOH. 
<??>A process for their preparation and the synthesis of peptide amides by the solid phase method using these novel compounds (spacers) are described.
Patent DK-264884-D0 (DK)
Inventor: SCHWEIZER MICHEL
IPC: C02F11/12
Filed: 1984-05-29
Abstract: 1. Process for the pre-treatment of sludges for improving their flocculation and/or dewatering behaviour in a subsequent dewatering apparatus, in which optionally polyelectrolytes are added as flocculating adjuvants, characterised in that the sludges are concentrated to a percentage of solids of at least 5% by weight, that prior to mechanical dewatering liquid combustible organic additives such as oils, particularly waste oil, are added to the sludge to be dewatered in an amount of from 0.5 to 50% by weight in relation to the percentage of solids of the sludge, and that in addition to the liquid combustible organic additives oxidizing agents, particularly hydrogen peroxide, oxygen or air, are added.
Patent DK-268884-D0 (DK)
Inventor: GHISALBA ORESTE
IPC: C12R1/38
Filed: 1984-05-30
Abstract: 1. Claims for Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Facultatively methylotrophic, DMF-degrading microorganisms of the genus Pseudomonas selected from the group of the following strains : DMF 3/3 (NRRL-B-15358), DMF 3/4 (NRRL-B-15359), DMF 3/5 (NRRL-B-15360), DMF 3/6 (NRRL-B-15361), DMF 3/11 (NRRL-B-15362), DMF 3/12 (NRRL-B-15363), DMF 4/4 (NRRL-B-15364), DMF 5/3 (NRRL-B-15365), DMF 5/5 (NRRL-B-15366), DMF 5/7 (NRRL-B-15367), DMF 5/8 (NRRL-B-15368), DMF 5/9 (NRRL-B-15369) and DMF 5/10 (NRRL-B-15370), the mixed culture DMF/HW 1-5 (NRRL-B-15371), a mutant derived from these microorganisms, or mixed cultures thereof, for the purification of industrial waste waters, characterised in that, in aqueous solution, they are able to degrade dimethylformamide, formamide, methyl- or ethyl-formamide, acetamide, methanol, ethanol, saccharides, lower alkanoates, methyl-, ethyl-, dimethyl- or trimethylammonium halides, dimethyl phosphite, trimethyl phosphite, hydantoin, creatine, creatinine, barbituric acid, choline, betaine, sarcosine, dimethylglycine, glycine, glyoxylic acid, N-formylamino acids, N-acetylamino acids, acetonitrile or isobutyronitrile or mixtures of these compounds, with an increase in the biomass. 1. Claims for Contracting State : AT A process for the microbiological purification of aqueous solutions containing dimethylformamide, formamide, methyl- or ethyl-formamide, acetamide, methanol, ethanol, saccharides, lower alkanoates, methyl-, ethyl-, dimethyl- or trimethyl-ammonium halides, dimethyl phosphite, trimethyl phosphite, hydantoin, creatine, creatinine, barbituric acid, choline, betaine, sarcosine, dimethylglycine, glycine, glyoxylic acid, N-formylamino acids, N-acetylamino acids, acetonitrile or isobutyronitrile or mixtures of these compounds, characterised in that there is cultured in such an aqueous solution a microorganism of the genus Pseudomonas selected from the group of the following strains : DMF 3/3 (NRRL-B-15358), DMF 3/4 (NRRL-B-15359), DMF 3/5 (NRRL-B-15360), DMF 3/6 (NRRL-B-15361), DMF 3/11 (NRRL-B-15362), DMF 3/12 (NRRL-B-15363), DMF 4/4 (NRRL-B-15364), DMF 5/3 (NRRL-B-15365), DMF 5/5 (NRRL-B-15366), DMF 5/7 (NRRL-B-15367), DMF 5/8 (NRRL-B-15368), DMF 5/9 (NRRL-B-15369) and DMF 5/10 (NRRL-B-15370), or a mutant derived from these microorganisms, or mixed cultures thereof, in the presence of essential inorganic salts and optionally a nitrogen source, at from approximately 20 degrees C to approximately 40 degrees C and at a pH of from approximately 4 to approximately 7.5, under aerobic conditions, and, if desired, the resulting biomass is isolated.
Patent DK-338788-D0 (DK)
Inventor: LAFONTEYNE JEAN DE
IPC: C12N15/00
Filed: 1988-06-21
Abstract: The invention relates to a process for transforming cells and to a recombinant DNA molecule for use therein. Said recombinant DNA molecule is a multifunctional linker comprising a DNA sequence which is homologous to a part of the receptor genome, an operator sequence and either a sequence which allows replication in a microorganism or a sequence which allows for integrative recombination in a vector. Preferably, said multifunctional linker also contains a gene whose expression can be detected in a microorganism, a gene whose expression can be detected in the receptor, a sequence which promotes recombination, and/or a hairpin structure at one or both ends. The transformation process uses donor DNA coupled to the multifunctional linker and allows for early success followed by further characterization of the donor DNA and its phenotypic impact.
Patent DK-344588-D0 (DK)
Inventor: MEAD DAVID EDWARD
IPC: A01G3/06
Filed: 1988-06-23
Abstract: A grass trimming device is capable of adopting at least two alternative configurations, in one of which a cutting plane is substantially horizontal for use in grass trimming, and in the other of which the cutting plane is substantially vertical for edge trimming. A parting plane (A) is defined by a housing (11,22,24) of the cutting head (10) such that rotation about an axis (B) perpendicular to this plane (A) through 180 DEG  results in the required switching. The shaft axis is preferably inclined at 10-15 DEG  with respect to the turning axis (B).
Patent DK-370588-D0 (DK)
Inventor: WOLFF ROBERT
IPC: B27F1/04
Filed: 1988-07-04
Abstract: The apparatus for milling grooves consists of a back square (1) and a carriage (5) which is displaceable on guides (6,7) provided on the back square, the carriage (5) carrying a drive motor for a milling disc (35), to which a slot-shaped passage opening (38) in the end plate (3) is assigned. 
<??>To lower the initial cost, provision is made according to the invention for the apparatus to be constructed as an attachment for a commercially available right angle grinder, the carriage (5) possessing two multi-member fastening angles (21, 22), between which the right angle grinder (18) can be firmly clamped, and a coupling shaft (13) being mounted in the carriage (5), in the top end (15) of which coupling shaft, possessing a threaded bore (16), the output threaded stem (17) of the right angle grinder (18) can be screwed, and to the bottom end of which coupling shaft the milling disc (35) can be screwed. 
<IMAGE>
Patent DK-442887-D0 (DK)
Inventor: FELDHUES MICHAEL
IPC: C25B3/29
Filed: 1987-08-25
Abstract: The intrinsically electrically conductive polymers, preferably oligomers, are, in the oxidised form, fully soluble in dipolar aprotic solvents at room temperature and contain structural units derived from at least one monomer of the formula (I) 
<IMAGE>
 in which R<1> is a C1-C12-alkoxy group or -O(CH2CH2O)nCH3 where n = 1 to 4 and R<2> is a hydrogen atom, a C1-C12-alkyl group, a C1-C12-alkoxy group or  -O(CH2CH2O)nCH3 where n = 1 to 4, or R<1> and R<2> together are -(OCH2)m-CH2 or -O(CH2)m-O- where m = 1 to 12. These polymers are prepared by electrochemical polymerisation of at least one monomer of this formula (I) in the presence of a conductive salt, where the anode has a specific surface area of at least 0.01 m<2>/g and preferably has a grid, sponge, woven or felt structure, the electrolyte solvent is dipolar and aprotic, and the electrolyte system is only agitated gently, or not at all, relative to the anode. The polymers according to the invention are particularly suitable for coating purposes.
Patent IT-8703499-D0 (IT)
Inventor: PILARI ADIMA
IPC: A21C11/02
Filed: 1987-05-29
Abstract: The improved machine for manufacturing short cut varieties of Italian pasta ("orecchiette", etc.) comprises three cascaded units: a first unit (1), with screw feeders, by which pasta mix is fed in and extruded into sticks; a second unit (6) by which the pasta sticks are cut into cylindrical pellets (7); and a third unit (13) by which the pasta pellets are gathered up and shaped, comprising a first knurled roller (14) and a forming plate (16) with a bead (17), which operate in conjunction to the end of flattening and curling the pellet (7), and a second roller in soft material that rotates in the opposite direction to the first roller (14) and interacts with a third roller (18), carrying a projection (19), to form the pasta into the typical cup shape of the varieties in question.
Patent NO-875155-D0 (NO)
Inventor: IMSGARD FINN
IPC: B27K3/34
Filed: 1987-12-10
Abstract: PCT No. PCT/DK87/00036 Sec. 371 Date Feb. 8, 1988 Sec. 102(e) Date Feb. 8, 1988 PCT Filed Apr. 9, 1987 PCT Pub. No. WO87/06176 PCT Pub. Date Oct. 22, 1987.Fungicides for preservation of wood, such as tributyltin oxide (TBTO) and tributyltin naphthenate (TBTN), are stabilized through inhibition of a normal autooxidation by addition of up to 1% of at least one metal salt of formula (I), wherein R is C4-C16 alkyl, aryl or alkylaryl, optionally substituted with oxygen, nitrogen, sulfur or halogen. R1 is C1-C4 alkyl, n is 0 or 1, and Me is calcium, magnesium, nickel, zinc, copper or cadmium when n is 0, and tin when n is 1. This results in significant inhibition of the degradation of the fungicide which takes place after application to the wood so that the fungicide maintains its activity for an extended period of time.
Patent NO-883275-D0 (NO)
Inventor: ARNOULD JEAN CLAUDE
IPC: A61P31/04
Filed: 1988-07-22
Abstract: Cephalosporin derivatives having a 3-position substituent of the formula I are described: <CHEM> wherein R<1> is hydrogen, alkenyl or optionally substituted alkyl, Het is a 5- or 6-membered heterocyclic ring bonded via a carbon atom to the amide linkage, wherein Het is selected from a group of the formulae II - III: <CHEM> wherein A is CH or a nitrogen atom; B is oxygen, sulphur or a group NR<4>; one or two of D, E, F and G are nitrogen atoms and the remainder are CH groups: or Het is a pyrazinone, pyridinone, pyridazinone or pyrimidinone ring, or is a thione equivalent of such a ring, said rings having a substituent R<4> on one nitrogen atom, or is pyranone, or pyranthione; the ring Het being fused by any two adjacent carbon atoms to the benzene ring; and Het being attached to the -CH2NR<1>CO- group via a carbon atom;      R<2> is hydroxy or an in vivo hydrolysable ester thereof; R<3> is ortho to R<2> and is hydroxy or an in vivo hydrolysable ester thereof; and R<4> has various values. The use of such compounds as antibacterial agents is described as are processes for their preparation and intermediates therefor.
Patent NO-885326-D0 (NO)
Inventor: EDGINGTON THOMAS S
IPC: C07K16/00
Filed: 1988-11-29
Abstract: Uses of monoclonal antibodies that bind to DNA segments defining a structural gene coding for a human tissue factor heavy chain protein are disclosed. Also disclosed are uses of monoclonal antibodies that bind to precursor forms and analogues of those proteins.
Patent NO-892870-D0 (NO)
Inventor: FROST JONATHAN
IPC: C07D491/10
Filed: 1989-07-11
Abstract: Compounds corresponding to the general formula (I) 
<IMAGE>
 in which Z denotes a group of formula -CH2-, -C(CH3)2-, -CH=CH-, -(CH2)2-, -(CH2)3-, -NH- or -N(CH3)CH2-, R1 denotes a hydrogen atom or an alkyl group, R2 denotes a hydrogen atom or a methyl group, and R3 denotes either an optionally substituted phenoxy group or a naphthyloxy group or an optionally substituted phenylmethyl group, or a bis(4-fluorophenyl)methyl group or an optionally substituted phenylmethoxy group or a (2-naphthyl)methoxy group or an optionally substituted phenoxymethyl group or a pyridinyloxy group, and R4 denotes a hydrogen atom, or else R3 and R4 form together and with the piperidine ring a spiro(2,3-dihydro-2:4'-benzofuran-1-piperidinyl) group. Application in therapy.