baber/WOPTO huggingface dataset:
Patent CA-3159912-A1 (CA)
Title: Nouvelles imitations de g-csf et leurs applications
Inventor: ELGAMACY MOHAMMAD
IPC: A61K38/00
Filed: 2020-12-17
Abstract: La présente invention se rapporte à une protéine ayant une activité de type G-CSF comprenant a) une ou deux chaîne(s) polypeptidique(s) ; b) un faisceau de quatre hélices alpha ; et c) deux ou trois lieur(s) d'acides aminés qui relient des hélices alpha formant un faisceau contigu qui sont situées sur la même chaîne polypeptidique, chaque lieur d'acide aminé ayant une longueur comprise entre 2 et 20 acides aminés. L'invention concerne également un polynucléotide et un vecteur codant la protéine de l'invention, des cellules hôtes comprenant ledit polynucléotide, un procédé de production de la protéine de l'invention et une composition pharmaceutique comprenant la protéine de l'invention. L'invention se rapporte en outre à des utilisations des protéines de l'invention en tant que réactif de recherche et l'utilisation de la protéine et/ou de la composition pharmaceutique la comprenant en tant que médicament, par exemple, pour une utilisation dans l'augmentation de la production de cellules souches, pour une utilisation dans l'induction de l'hématopoïèse et/ou pour une utilisation dans la mobilisation de cellules souches hématopoïétiques.
Patent CA-3160397-A1 (CA)
Inventor: MACPHAIL WARREN
IPC: F16K15/18
Filed: 2020-12-21
Abstract: La présente description se rapporte à des procédés et des systèmes pour des opérations de fracturation-à-fracturation asynchrones permettant la récupération d'hydrocarbures. Les procédés peuvent consister à utiliser des soupapes d'injection uniquement et de production uniquement qui comprennent un boîtier et au moins un manchon ainsi que des éléments de restriction d'écoulement, des clapets anti-retour, ou d'autres caractéristiques. L'élément de restriction d'écoulement peut être une voie alambiquée prévue dans le manchon. Les clapets anti-retour peuvent être intégrés dans le manchon ou dans le boîtier de la soupape. Divers types différents d'ensembles soupape peuvent être utilisés et intégrés dans des éléments de restriction d'écoulement et/ou des clapets anti-retour.
Patent CA-3161396-A1 (CA)
Inventor: SADLEIR JOHN WILLOUGHBY
IPC: A61M5/172
Filed: 2020-12-11
Abstract: A medication delivery apparatus (90). The medication delivery apparatus (90) comprises a first plunger (92); a second plunger (94); and a container (96) configured to receive the second plunger (94) and at least a portion of the first plunger (92). The container (96) and the second plunger (94) together define a dilution chamber (100) that is configured to receive a diluent. The dilution chamber (100) comprises a dilution chamber opening (110). The dilution chamber opening (110) is defined by the container (96). The first plunger (92), the container (96) and the second plunger (94) together define an active agent chamber (98). The active agent chamber (98) is configured to receive a pharmaceutical preparation. The active agent chamber (98) comprises a first active agent chamber opening (103) configured to receive the at least a portion of the first plunger (92). The second plunger (94) comprises a valve (102) configured to control a flow of pharmaceutical preparation from the active agent chamber (98) to the dilution chamber (100) in response to applied pressure.
Patent CA-3161853-A1 (CA)
Inventor: DUPONT GUILHEM
IPC: G16H50/20
Filed: 2021-01-08
Abstract: La présente invention concerne des procédés permettant de fournir l'état pathologique d'un sujet, comprenant les étapes consistant à déterminer au moins deux paramètres représentant l'état d'une maladie du sujet à un premier instant ; à combiner les paramètres déterminés pour obtenir une signature représentant l'état pathologique au premier instant ; à répéter les étapes précédentes pour obtenir au moins une autre signature à un instant ultérieur ; et à combiner les signatures obtenues à l'étape précédente pour fournir un marqueur de progression indiquant l'état pathologique du sujet. L'invention concerne en outre une composition pharmaceutique destinée à être utilisée pour le traitement d'une maladie du système nerveux central (SNC). L'invention concerne également un dispositif mobile exécutant les procédés selon l'invention.
Patent CA-3162190-A1 (CA)
Title: Fire pit ash cleanup
Inventor: RESSLER KYLE
IPC: F24B1/191
Filed: 2022-06-15
Abstract: A fire pit has a combustion chamber with a perforated floor, a chute below the perforated floor directing ash and debris from the floor to an area below the chute, and a removable ash pan occupying the area below the chute and having a handle affixed thereto.
Patent CA-3163911-A1 (CA)
Inventor: HEYES JAMES
IPC: A61K38/17
Filed: 2020-12-07
Abstract: L'invention concerne certains acides nucléiques (par exemple, des molécules d'ARNsi double brin), ainsi que des conjugués qui comprennent une fraction de ciblage, un ARNsi double brin et des groupes de liaison facultatifs.<i /> Certains modes de réalisation concernent également des procédés de synthèse utiles pour la préparation des conjugués. Les conjugués sont utiles pour traiter certaines maladies, telles qu'une fibrose hépatique, par exemple, au début d'une SHNA ou d'une SHA.<i />
Patent CA-3164728-A1 (CA)
Title: Egg positioning device
Inventor: STUTTERHEIM WIL MARIJN
IPC: G01N33/08
Filed: 2021-01-18
Abstract: The present invention relates to a computer-controlled system for non-invasively identifying the location of the air cell (304) of an egg (104) and determining a preferred extraction point (305) relative to the position of the air cell of the egg, the system comprising: a. an egg manipulator (106) to hold and orient one or more eggs in a defined position; b. a candling unit (100) comprising one or more light sources (301) and one or more detectors (302); c. a system which is configured to run an algorithm for determining the location of the air cell of the egg and the preferred extraction point; and d. a system for positioning the egg relative to an extractor (200) or an egg opener (303) from its initial position to the preferred extraction point (305).
Patent CA-3165939-A1 (CA)
Title: Echafaudages pour ingenierie tissulaire
Inventor: WEISS ANTHONY STEVEN
IPC: A61L27/26
Filed: 2021-02-08
Abstract: La présente divulgation concerne un matériau hybride, tels qu'un fil hybride, ainsi que des procédés de fabrication et d'utilisation y relatifs. Le matériau hybride peut comprendre de la tropoélastine. En outre, le matériau hybride peut également comprendre un polymère biodégradable. De plus, l'invention concerne également des compositions et des procédés pour traiter un tissu, tel que le traitement d'un prolapsus d'organe.
Patent CA-3168451-A1 (CA)
Inventor: DUTTA ANINDITA
IPC: G16B40/20
Filed: 2021-02-17
Abstract: The technology disclosed compresses a larger, teacher base caller into a smaller, student base caller. The student base caller has fewer processing modules and parameters than the teacher base caller. The teacher base caller is trained using hard labels (e.g., one-hot encodings). The trained teacher base caller is used to generate soft labels as output probabilities during the inference phase. The soft labels are used to train the student base caller.
Patent CA-3169895-A1 (CA)
Title: Method and system for predicting trapped air mass in a two-stroke engine
Inventor: BUCHWITZ JAMES H
IPC: F02D41/34
Filed: 2019-11-28
Abstract: A method and system for operating a two-stroke engine includes a fuel system comprising a fuel pressure sensor, fuel temperature sensor and a fuel injector and a controller in communication with the fuel pressure sensor and fuel temperature sensor.  The controller controls the fuel injector with a fuel pulsewidth determined by determining a beginning time of a window for measuring fuel pressure, determining an ending time of the window, measuring fuel pressure between the beginning time and the ending time, determining a fuel pulsewidth based on the fuel pressure and fuel temperature and injecting fuel into the two-stroke engine in response to a desired fuel mass.
Patent CA-3170839-A1 (CA)
Title: Muscle-specific nucleic acid regulatory elements and methods and use thereof
Inventor: VANDENDRIESSCHE THIERRY
IPC: C07K14/47
Filed: 2021-02-18
Abstract: The present invention relates to nucleic acid regulatory elements that are able to enhance muscle-specific expression of genes, in particular expression in muscle cells and/or tissues such as in diaphragm, smooth muscle, heart and/or skeletal muscle, comprising at least two diaphragm-specific regulatory elements and a heart- and skeletal muscle-specific regulatory element. The present invention further relates to expression cassettes and vectors containing these nucleic acid regulatory elements, as well as uses thereof. The present invention is particularly useful for applications using gene therapy of muscle-related disorders, more particularly diaphragm, heart and/or skeletal muscle-directed gene therapy, and for vaccination purposes.
Patent CA-3172264-A1 (CA)
Title: Device and method for preparing compartmentalized in vitro models with an elongated component of a biological material
Inventor: GEORGE SUBIN MAC
IPC: C12M3/00
Filed: 2022-06-16
Abstract: There is provided a cell culture device for preparing a compartmentalized in vitro model using neuronal cells. The cell culture device can include an insert insertable in a reservoir of a cell culture plate, a microfluidic layer receivable on or within the insert and an upwardly extending feed well. The microfluidic layer includes channels for orienting axonal growth, and the feed well includes a seeding chamber to receive the neuronal cells therein, the seeding chamber being configured to be in fluid communication with the channels of the microfluidic layer. Alternatively, the cell culture device can include a multi-well insert that includes a plurality of insert wells configured to receive a microfluidic layer therein, the insert wells being in fluid communication with a feed well that is configured to receive the neuronal cells therein. The cell culture device can further include an electrode layer provided in proximity of the microfluidic layer.
Patent CA-3172959-A1 (CA)
Inventor: ABAL DANIEL M
IPC: A61M5/50
Filed: 2022-09-13
Abstract: An apparatus, method, and system for detecting a leaking occluder valve is disclosed.  Upper and lower occluder elements of an infusion pump are activated to compress a fluid tubing filled with a fluid to isolate the fluid in an upstream portion of the tubing from a downstream portion of the tubing. While the fluid tubing is compressed by the occluder elements, a pumping element of the infusion pump is activated to compress an intermediate portion of the tubing, between the downstream portion and the upstream portion, to cause a pressure increase within the fluid tubing. Using at least one pressure sensor, a determination is made as to whether the pressure increase is present in a portion of the fluid tubing on a side, of an activated occluder element, opposite the intermediate portion of the tubing.
Patent CA-3173160-A1 (CA)
Inventor: MANN BRENDA K
IPC: G02C7/04
Filed: 2021-03-23
Abstract: L'invention concerne un système d'administration de médicament oculaire qui comprend une lentille de contact et une partie d'administration de médicament, qui peut comprendre un composé de formule X-(CH2)) n-Z, X étant un groupe photoréticulable. Avantageusement, la partie d'administration de médicament peut aider à charger une concentration élevée d'un agent thérapeutique chargé négativement dans le système d'administration de médicament oculaire. De plus, le système d'administration de médicament oculaire selon l'invention peut aider à administrer de manière contrôlée l'agent thérapeutique chargé négativement à l'?il d'un patient sur une période d'environ 4 à environ 24 heures.
Patent CA-3173260-A1 (CA)
Inventor: PETERS RON A
IPC: E05C1/06
Filed: 2022-09-12
Abstract: A deadbolt control and security system for preventing rotation of a deadbolt manual egress handle of a deadbolt lock is described herein. The system preferably includes a deadbolt interface unit and at least one actuator unit.  The deadbolt interface unit has a manual mode (the deadbolt interface unit manual egress handle controlling locking and unlocking the deadbolt lock) and a remote mode (the at least one actuator unit controlling locking and unlocking the deadbolt lock).  The deadbolt interface unit includes: a deadbolt interface unit manual egress handle; a gear train having a shaft coordinated with the deadbolt interface unit manual egress handle;  a unit-handle coupler that interfaces between the deadbolt manual egress handle and the deadbolt interface unit manual egress handle via the shaft; and a clutch.  Preferred systems prevent the deadbolt lock from being unlocked using keys and/or other bypass tools.
Patent CA-3175203-A1 (CA)
Inventor: KAWAHARA MOE
IPC: C08L53/02
Filed: 2021-04-08
Abstract: A thermoplastic elastomer composition is provided that can be adjusted to a wide range of hardness, has excellent tensile characteristics and shaping processability, and exhibits excellent bond strength even with respect to highly polar materials.  A related laminate structure and a method for producing the laminate structure are also provided.  The thermoplastic elastomer composition includes an acrylic block copolymer (I) and a hydrogenated block copolymer (II).  In the thermoplastic elastomer composition, the content of the acrylic block copolymer (I) is 70 to 300 parts by mass with respect to 100 parts by mass of the hydrogenated block copolymer (II); the hydrogenated block copolymer (II) is a hydrogenated product of a block copolymer (P) including a polymer block (A1) containing structural units derived from an aromatic vinyl compound, and a polymer block (B1) containing 1 to 100 mass% of structural units (b1) derived from farnesene and 99 to 0 mass% of structural units (b2) derived from a conjugated diene other than farnesene, the mass ratio [(A1)/(B1)] of the polymer block (A1) to the polymer block (B1) being 1/99 to 70/30; and the hydrogenation ratio of carbon-carbon double bonds in the polymer block (B1) is 50 to 100 mol%.  The laminate structure includes a layer formed of the thermoplastic elastomer composition.  The method produces such a laminate structure.
Patent CA-3175939-A1 (CA)
Inventor: SHENG WEI
IPC: G06F16/176
Filed: 2019-09-30
Abstract: Provided are a block chain-based blacklist data sharing method and system, which relates to the field of block chain technology, the convenience and effectiveness of blacklist data acquisition can be ensured by introducing block chain technology into the application scenarios of blacklist data, and the sharing value of blacklist data is improved. The method includes: member institutions build their own network nodes, the network nodes to which each member institution belongs are networked sequentially to construct the block chain, the network nodes include business nodes and token nodes; initiating blacklist data upload request via any business node, using the generated symmetric key to encrypt the blacklist data while using the random public key to encrypt the symmetric key, packing the encrypted blacklist data and the encrypted symmetric key onto the chain, and when the account is received onto the chain, the associated token node requests to transfer the token to the specified token address; the system includes the method mentioned in the above solution.
Patent CA-3176103-A1 (CA)
Title: Lymphocytes t v delta1+ pour le traitement de malignites myeloides
Inventor: SIMOES ANDRE GONCALO DO ESPIRITO SANTO
IPC: A61P35/02
Filed: 2020-03-20
Abstract: L'invention concerne des compositions comprenant des lymphocytes T Vd1+, destinées à être utilisées dans le traitement de malignités myéloïdes. La présente invention concerne également des méthodes de traitement faisant appel auxdites compositions.
Patent CA-3177289-A1 (CA)
Inventor: MCGEE JOHN K
IPC: E05D15/16
Filed: 2021-04-30
Abstract: In example a panel for an overhead sectional door is provided. The panel includes a laminate core, a laminate skin, and a universal fabric hinge. The laminate skin is coupled to two opposing sides of the laminate core. The universal fabric hinge is coupled to the laminate skin to connect the panel to an adjacent panel of the overhead sectional door.
Patent CA-3180145-A1 (CA)
Inventor: WANG DINGHUI
IPC: H02K5/18
Filed: 2020-09-10
Abstract: A cooling system, comprising: a heat exchanger module, wherein the heat exchanger module at least comprises a first channel and a second channel that are independent from each other; a first cooling circuit, wherein the first cooling circuit is connected to the first channel of the heat exchanger module; and a second cooling circuit, wherein the second cooling circuit is connected to the first channel of the heat exchanger module, and a first coolant in the first cooling circuit and/or a second coolant in the second cooling circuit can flow through the first channel of the heat exchanger module so as to be used for performing heat exchange with a third coolant that flows through the second channel of the heat exchanger module. According to the cooling system, the reliability of the cooling system can be improved by means of the design of dual cooling circuits.
Patent CA-3181601-A1 (CA)
Inventor: CHOI MAN HO
IPC: B25J5/00
Filed: 2022-11-09
Abstract: A method of operating a mowing system, the method including mowing within a work area, wherein mowing is performed by a robotic lawn mower, and wherein the work area comprises a plurality of base stations each configured to charge the robotic lawn mower; determining when to charge the robotic lawn mower in view of a current charge level and a current location of the robotic lawn mower.
Patent CA-3182865-A1 (CA)
Title: Variable-geometry spacing connector for formwork and modular formwork system including such connector
Inventor: CABONI MICHELE
IPC: E04B2/86
Filed: 2012-01-10
Abstract: The description herein refers to a spacing connector (1) used for assembling formworks (11) and made up of at least one crosspiece (3), said crosspiece (3) being connected, at both of its opposite ends, with at least one respective connection portion (5) suited to make a connection with at least one panel (10) of such formwork (11), said spacing connector (1) also including at least one transpiration duct featuring two respective end openings (15), each of said end openings (15) leading to a respective said connection portion (5). The description herein also refers to a formwork system including said spacing connectors (1).
Patent CA-3184024-A1 (CA)
Inventor: COCO JOHN
IPC: A61K31/4192
Filed: 2021-06-23
Abstract: Provided herein are method of treating cancers using a first anti-cancer agent and at least one second anti-cancer agent, wherein the first anti-cancer agent is represented by Formula (I): or a pharmaceutically acceptable salt thereof. Compositions comprising the disclosed first anti-cancer agent and at least one second anti-cancer agent are also provided.
Patent CA-3189959-A1 (CA)
Inventor: THANNHUBER MARKUS
IPC: H02J7/00
Filed: 2023-02-15
Abstract: According to a method for controlling a first electric appliance (4) by means of a battery pack (1), which is selectively connectable to the first electric appliance (4) and at least one second electric appliance, a generic software for controlling the first electric appliance (4) and the at least one second electric appliance is stored on a storage element of the battery pack (1). Identification information, which identifies the first electric appliance (4), is obtained by the battery pack (1) and configuration information is requested and obtained from an external computer system (10) by means of the battery pack (1) depending on the identification information. The software is configured according to the configuration information and the first electric appliance (4) is controlled by means of the battery pack (1) by execution of the configured software.
Patent CA-3190158-A1 (CA)
Inventor: PHARES DENIS
IPC: H01M10/0565
Filed: 2021-08-11
Abstract: Powderized solid-state electrolytes and electroactive materials as well as related methods of manufacturing and use are disclosed. In one embodiment, an ionically conductive powder comprises a plurality of ionically conductive particles. The ionically conductive particles may comprise an ionically conductive salt dissolved in a thermoplastic polymer, with optional components (e.g., electroactive and/or inorganic solid particles) dispersed within. Related methods of producing these ionically conductive powders are also disclosed including, but are not limited to, low-temperature milling, spray drying, and aerosol polymerization. Embodiments related to using the resultant ionically conductive powders in a spray deposition process are also described.
Patent CA-3190800-A1 (CA)
Title: Pellicle membrane for a lithographic apparatus
Inventor: VAN DER WOORD TIES WOUTER
IPC: G03F1/62
Filed: 2021-08-05
Abstract: A pellicle membrane for use in a lithographic apparatus, said pellicle membrane characterised by inplane variation in composition is described. Also described is a method of manufacturing a pellicle membrane, said method including the steps of: a) providing a sacrificial layer on a substrate: b) providing a first material layer on the sacrificial layer; c) providing a photoresist layer on the first material layer; d) patterning the photoresist layer; e) etching the first material layer to form a patterned surface; and f) either i) depositing a layer of a second material on the patterned surface and subsequently lifting off the portion of the second material deposited on the patterned photoresist layer, or ii) removing the remaining photoresist layer, depositing a layer of a second material on the patterned surface, and subsequently planarizing the surface.
Patent CA-3190894-A1 (CA)
Title: Bagage dote d'une poche de batterie externe
Inventor: PHILLIPS JUAN EMILIO
IPC: A45C5/03
Filed: 2021-08-27
Abstract: Un article de bagagerie peut comporter des coques dures avant et arrière qui définissent un compartiment d'emballage. Un matériau d'expansion peut s'étendre entre les coques dures lorsque l'article de bagagerie est fermé. Une poche peut être fixée au matériau d'expansion et comporter une poche s'ouvrant à travers le matériau d'expansion. La poche peut être dimensionnée pour contenir une batterie externe. Un orifice peut être disposé le long d'un côté extérieur de l'article de bagagerie pour coupler électriquement la batterie externe à l'intérieur de la poche avec un dispositif électrique à l'extérieur de l'article de bagagerie.
Patent CA-3191262-A1 (CA)
Title: Methods of preparing modified dosage forms and related components
Inventor: TANEJA RAJNEESH
IPC: B01F31/00
Filed: 2021-08-30
Abstract: Provided are methods of preparing a homogeneous mixture from a solid dosage form in settings including a point of care setting. The methods include obtaining a solid dosage form comprising a drug product, adding the solid dosage form to a container having at least one flexible section, adding a liquid to the container, mixing the solid dosage form with the liquid to disperse, disintegrate, suspend, and/or dissolve the solid dosage form thereby creating a homogeneous mixture. Also provided are containers and devices for use in such methods.
Patent CA-3192449-A1 (CA)
Inventor: SIMS RYAN MATTHEW
IPC: G05B19/042
Filed: 2016-04-14
Abstract: An actuator-controlled electric strike operates in conjunction with a latch having an engaged position to secure a door in a closed state and a released position. The strike comprises a housing defining an entry chamber. A keeper is disposed in the entry chamber about an axis for rotation between a locked position and an unlocked position. A unitized actuator module is provided including a body, a keeper release and an actuator movable between first and second positions. When the actuator is in one of the first or second positions the keeper release is coupled to the keeper and the keeper is secured in the locked position. When the actuator is selectively moved to the other of the first or second positions the keeper release is decoupled from the keeper and the keeper is rotatable to the unlocked position.