baber/WOPTO huggingface dataset:
Patent ES-8406475-A3 (ES)
Title: Methyl ester prepn. of di:hydro-eburnamenine carboxylic acid
IPC: C07D461/00
Filed: 1983-05-13
Abstract: Deriv. of the methyl ester of 14,15-dihydro 14-beta-hydroxy (3 alpha, 16 alpha) eburnamenine 14-carboxylic acid, of formula (I) is made by reacting 14,15-dihydro 14 beta-hydroxy (3 alpha, 16 alpha) eburnamenine 14-carboxylic acid with diazoethane in a non-polar solvent such as ether, a hydrocarbon or halogenated hydrocarbon at around 0 deg.C..
Patent SK-113097-A3 (SK)
Title: Parenteral pharmaceutical preparations containing ammonium alkyl salts of 2-arylpropioninc acids
Inventor: GENTILE MARCO
IPC: A61K9/08
Filed: 1996-12-23
Abstract: Parenteral pharmaceutical compositions containing alkylammon ium salts of 2-arylpropionic acids, having anti-inflammatory and analgesic properties, where the acids are selected from the group comprising ketoprofen, ibuprofen, naproxen, thiaprofenic acid, i n the racemic as well as in the enantiomeric form, whilst the sal t is in the aqueous solution with osmolarity between 270 and 310 mOsm/kg and with pH in the range between 7.0 and 7.5, where the s aid solution is without protective substances and carrying substa nces and is kept in the atmosphere of an inert gas. Disclosed is also their preparation method.
Patent SK-125998-A3 (SK)
Title: Use of metoclopramide
Inventor: PSILOGENIS MARY
IPC: A61K33/243
Filed: 1997-03-13
Abstract: The present invention is directed to a method for the prophy lactic management of delayed emesis by the use of metoclopramide nasal spray.
Patent SK-131393-A3 (SK)
Title: Method of preparation of magnesium sulphonates with high basicity number
Inventor: CLEVERLEY JOHN A
IPC: C10M159/24
Filed: 1992-05-19
Abstract: PCT No. PCT/EP92/01113 Sec. 371 Date Nov. 23, 1993 Sec. 102(e) Date Nov. 23, 1993 PCT Filed May 19, 1992 PCT Pub. No. WO92/20694 PCT Pub. Date Nov. 26, 1992.The use of magnesium oxide of specified, low, reactivity in a process for the production of overbased magnesium sulphonates, together with the introduction of water and an alcohol, into the reaction mixture during carbonation, makes it possible to prepare high base number products which have very low post carbonation sediments and which can be purified by rapid filtration.
Patent SK-137695-A3 (SK)
Title: Method of manufacture for solid castings from liquid reactive medium, device for carrying out the method and oven for heating of liquid medium
Inventor: MALLAH MOHAMAD
IPC: H05B6/70
Filed: 1994-04-25
Abstract: PCT No. PCT/EP94/01275 Sec. 371 Date Jan. 30, 1995 Sec. 102(e) Date Jan. 30, 1995 PCT Filed Apr. 25, 1994 PCT Pub. No. WO94/26077 PCT Pub. Date Nov. 10, 1994The present invention relates to a process for the manufacture of castings from an essentially liquid reactive medium as casting material which, above its gelation temperature, reacts to form a solid material. The liquid reactive medium is fed from a supply tank, in which the temperature of the casting material lies substantially below its gelation temperature. The liquid reactive medium is fed into a casting mould which has been heated to a temperature that lies above the gelation temperature of the casting material. The casting material is substantially preheated directly before it enters the casting mold to a temperature close to but below the gelation temperature of the casting material.
Patent SK-141096-A3 (SK)
Title: Joint prosthesis
Inventor: ELHAMI LAGHAOLLAH
IPC: A61B17/74
Filed: 1995-04-18
Abstract: PCT No. PCT/DE95/00481 Sec. 371 Date Jan. 6, 1997 Sec. 102(e) Date Jan. 6, 1997 PCT Filed Apr. 18, 1995 PCT Pub. No. WO95/29650 PCT Pub. Date Nov. 9, 1995The invention relates to a joint prosthesis with a cap having a supporting surface, a telescopic arrangement having a telescopic component on a cap side and a telescopic component on a holder side and connected to a holder for securing to a bone surface, wherein the supporting surface is formed by an inner surface of the cap which is at least approximately shaped to fit the bone head. A restricting device acts dependently upon the direction so as to allow the cap to be moved in relation to the holder in a direction away from the socket and to prevent or at least hamper movement towards the socket. Also disclosed is a surgical device for making a drilling with a bush to accept an instrument and a system connected to the bush to accept the joint head at least partially; the median longitudinal axis of the bush is brought into relation with the periphery of the joint head in order to facilitate the positioning of the device in relation to the bone system.
Patent SK-157498-A3 (SK)
Title: Isolated and recombinant nucleic acid, bas-1 protein or peptide thereof, and agent, antibody, expression vector, host cell and method of their use
Inventor: LIU YONG-JUN
IPC: C12N15/02
Filed: 1997-05-15
Abstract: The purification and isolation of a gene which encodes a human B-cell antigen. Nucleic acids, proteins, antibodies, and other reagents useful in modulating development of cells, e.g., lymphoid, are provided, along with methods for their use.
Patent SK-167798-A3 (SK)
Title: Dihydrobenzopyran and related compounds useful as anti-inflammatory agents
Inventor: JANUSZ JOHN M
IPC: C07D335/04
Filed: 1997-06-06
Abstract: PCT No. PCT/US97/09945 Sec. 371 Date Dec. 7, 1998 Sec. 102(e) Date Dec. 7, 1998 PCT Filed Jun. 6, 1997 PCT Pub. No. WO97/46548 PCT Pub. Date Dec. 11, 1997A compound having structure (1) wherein (a) X is selected from the group consisting of O, S, SO, or SO2; (b) each Y is independently hydrogen or straight, branched or cyclic alkanyl having from 1 to about 4 carbon atoms, or the two Y's are bonded to form an alkanyl ring having from 3 to about 7 carbon atoms; (c) Z is branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; (d) W is O or S; and (e) R is straight, branched or cyclic alkyl or aryl, saturated or mono- or di-unsaturated with double or triple bonds, R having from 1 to about 15 atoms other than hydrogen; pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
Patent SK-169792-A3 (SK)
Title: Shaft coupling with pneumatical-elastic units
Inventor: HOMISIN JAROSLAV
IPC: F16D25/04
Filed: 1992-06-05
Abstract: Shaft-coupling with pneumatical-elastic units is determinated for securing stabil elastic transfer of freight screw moment in torsial vibrating mechanical systems. Freight screw moment from driving body (1) to driven body (1) of coupling is transferred with pneumatical-elastic units (3) filled with gas medium. Mutual connecting of pneumatical-elastic units (3) is secured with connecting (4), which is at the sometime created between external ends (5) of corresponding units.
Patent SK-392192-A3 (SK)
Title: Method and arrangement for producing spunlace and material produced thereby
Inventor: BILLGREN TOMAS
IPC: D04H1/492
Filed: 1991-11-18
Abstract: PCT No. PCT/SE91/00779 Sec. 371 Date May 11, 1993 Sec. 102(e) Date May 11, 1993 PCT Filed Nov. 18, 1991 PCT Pub. No. WO92/08832 PCT Pub. Date May 29, 1992.The present invention relates to a method for producing spunlace material in which there is formed a fibrous web by air-laying a layer of fibres of staple length on a forming wire and air-laying a layer of short fibres on top of the layer of staple fibres. According to the invention, the fibrous web is passed to an entangling wire 18 on which there is arranged at least one elongated element 17 whose diameter is much greater than the diameter of the wires 16 in the entangling wire 18, whereafter the fibrous web is entangled. The invention also relates to an arrangement for carrying out the method, and to a spunlace material produced in accordance with the method.
Patent SK-400992-A3 (SK)
Title: Quinazolines derivatives for enhancing antitumor activity
Inventor: COE JOTHAM W
IPC: C07D491/056
Filed: 1991-10-10
Abstract: PCT No. PCT/US91/07254 Sec. 371 Date May 5, 1993 Sec. 102(e) Date May 5, 1993 PCT Filed Oct. 10, 1991.2,4-Diaminoquinazoline derivatives as potentiators of chemotherapeutic agents in the treatment of cancer.
Patent SK-582011-A3 (SK)
Inventor: KALISKY ALEXANDER
IPC: F25B21/00
Filed: 2011-06-17
Abstract: Zariadenie s tepelným magnetickým cyklom premieňa teplo
rôzneho zdroja s rôznou teplotou hladiny na mechanickú
alebo priamo na elektrickú energiu. V obrátenom cykle je
produkciou chlad a teplo. Významná je možnosť hlbokého
chladenia v jednom cykle bez medzichladičov pri skvapalňovaní
technických plynov a vzduchu pre preplňované motory.
Vo vyhotovení solárneho motora je výhodou zúžitkovanie
vysokých teplôt silne koncentrovaného žiarenia
a kaskádne využitie teplotného spádu 1000 K bez tlakového
namáhania konštrukčných prvkov zariadenia, bez fluidných
a kvapalných teplonosných médií.
Patent SK-782016-A3 (SK)
Inventor: SUKHODUBOV OLEKSANDR
IPC: F24D11/00
Filed: 2016-08-03
Abstract: Spôsob zachovania prirodzenej teploty vzduchu pomocou vytvorenia umelého ložiska teplého vzduchu patrí do oblasti využívania prírodných zdrojov a je navrhnutý na vykurovanie budov a výrobu elektrickej energie. Do horninových štruktúr určených na vtláčanie zemného plynu sa pomocou technológií na vtláčanie zemného plynu namiesto zemného plynu vtláča plyn - horúci letný vzduch, ktorý sa používa v zimnom období na priame vykurovanie budov a výrobu elektrickej energie pomocou tepelných čerpadiel. Pri tomto spôsobe sa využívajú ložiská a technológie, umožňujúce vtláčať, ukladať a následne využívať (ťažiť) horúci vzduch. Vrty, ktoré v lete pracujú ako absorpčné, sa v zime využívajú na odber teplého vzduchu. V tomto procese vzduch môže nielen zachovávať svoju teplotu, ale aj sa zohrievať vďaka prirodzenej teplote zeme. Celkový počet vrtov sa môže líšiť v závislosti od technických i prírodných podmienok ložiska. V tejto metóde vykurovania obydlí sú vylúčené emisie uhličitých plynov a znižuje sa tepelné zaťaženie na povrch zeme vďaka „zužitkovaniu" horúceho vzduchu v letnom období. Celý tento proces vedie k zníženiu zahrievania povrchu zeme.
Patent WO-9961739-A3 (WO)
Title: Mecanisme de fermeture pour portes et fenetres
Inventor: KRAL JOSEPH MICHAEL
IPC: E05D15/10
Filed: 1999-05-25
Abstract: La présente invention concerne un mécanisme d'ouverture et de fermeture pour fenêtres et de fermeture automatique pour portes. Un porte-galets (9) se déplace le long de l'axe central d'une glissière primaire (4). Par voie de conséquence, un galet (7) monté sur le porte-galets (9) exerce une force sur l'un ou l'autre bord d'une encoche (8) dans le bras (1), lequel est monté pivotant dans la glissière primaire (4) à l'une de ses extrémités, et agit sur une glissière secondaire (6) via un coulisseau (5) monté pivotant dans l'extrémité extérieure du bras (1). Les axes centraux de la glissière primaire (4) et de l'encoche (8) du bras (1) se coupent selon un angle aigu (13) relativement constant. Lorsque le porte-galets (9) est muni d'un ressort qui exerce une tension constante dans la direction opposée au point de pivotement (3) du bras (1), ce ressort provoque la fermeture automatique de la porte ou de la fenêtre. On peut jouer sur l'angle (13) pour augmenter ou réduire la vitesse et la force d'exécution.
Patent BE-1000884-A3 (BE)
Title: Inrichting voor het vormen van een gaap bij weefmachines.
Inventor: VAN SEVEREN JORIS
IPC: D03C13/00
Filed: 1987-08-26
Granted: 1989-05-02
Abstract: Inrichting voor het vormen van een gaap bij weefmachines, daardoor gekenmerkt dat zij hoofdzakelijk bestaat uit eerste middelen (1) die verbonden zijn met en/of deel uitmaken van de hevels (2) van de kettingdraden (3); tweede middelen (4) die heen en weer beweegbaar zijn, waarmee de eerste middelen (1) kunnen verplaatst worden en stuurbare vergrendelingsmiddelen (5) die met de eerste middelen (4) kunnen samenwerken teneinde deze in een bepaalde positie te brengen en/of te houden.
Patent BE-1000440-A3 (BE)
Title: Procede et dispositif pour fabriquer des sacs en matiere synthetique predecoupes et en bobine.
Inventor: TEYSSIER MICHEL
IPC: B31B27/00
Filed: 1987-11-23
Granted: 1988-12-06
Abstract: Bobines de sacs dans lesquelles les lignes de perforation pour la séparation des sacs de la bande sont composées d'une série de perforations réalisées par poinçonnage à chaud. Selon l'invention, le procédé consiste à réaliser simultanément les deux séries de perforations au moyen d'un seul outil. L'une des machoires du dispositif est composée d'une barrette en matériau isolant (16) portant une résistance de chauffage (18) munie d'une denture (18b). La résistance (18) est raccordée électriquement à une barrette en matériau conducteur (17) disposée dans le prolongement de la barrette (16) et portant une lame dentée tranchante (22).
Patent BE-1003085-A3 (BE)
Title: Systeme pour la detection instantanee de la casse d'un fil de trame a l'interieur de la foule d'un metier multiphases.
Inventor: CORAIN LUCIANO
IPC: D03D47/26
Filed: 1988-11-17
Granted: 1991-11-19
Abstract: Le système pour la détection instantanée de la casse d'un fil de trame à l'intérieur de la foule d'un métier multiphases comprend une série de solénoïdes à boucle fermée qui s'étendent successivement le long de l'ensemble de la zone de tissage pour coopérer avec les rotors (13) de fil de trame de navette qui sont équipés d'au moins un élément magnétique excentré (17).
Patent BE-1003270-A3 (BE)
Title: Tertiary alkyl- and cycloalkyl-hydroperoxide production method
Inventor: MASPERO FEDERICO
IPC: C07C409/02
Filed: 1990-11-14
Granted: 1992-02-11
Abstract: This consists of a simple method for producing tertiary alkyl- andcycloalkyl-hydroperoxides according to the general formula (I) where R is atertiary alkyl or cycloalkyl radical, possibly substituted by the reactionwith H2O2 of the corresponding alkanol or cycloalkanol according to theformula (II) R-OH (II) in the presence of a synthetic zeolite containingtitanium. Such a method, particularly of interest in producing t-butyl- andt-amyl-hydroperoxide, makes is possible to obtain, with optimal yields, thedesired product which is fundamentally free of the corresponding peroxide.
Patent BE-1010305-A3 (BE)
Title: Lower tool for a layer separator in a machine for making components in plates or in sheets
Inventor: DE SOMER JEAN-MARIE
IPC: B26D7/18
Filed: 1996-06-27
Granted: 1998-05-05
Abstract: The invention relates to a lower tool (5) for a layer separator in a machine for making components in plates or in sheets for the purpose of producing packaging, in wood or agglomerated material, comprising arranging devices (8) allowing separate layers to be stacked vertically, wherein these arranging devices each comprise a fixed part (16) and a moving part (18), the fixed part of each of the arrangers is anchored to the lower tool (5) by being set in slots (17) provided in it, the moving part (18) of each of the arrangers is an elongated U-shaped tab, mounted as a rider on a central part of the fixed part (16).<IMAGE>
Patent WO-0212456-A3 (WO)
Title: Serine/threonine kinase apparentee a ampk, appelee snark
Inventor: DRUCKER DANIEL J
IPC: C12N5/10
Filed: 2001-08-02
Abstract: La présente invention concerne le clonage et le fonctionnement d'une nouvelle kinase apparentée à AMPK, appelée SNARK. La kinase SNARK est impliquée dans la réaction de stress produite par la privation de glucose. Cette invention concerne les gènes de rongeurs et d'humain codant SNARK, ainsi que la protéine SNARK et ses fragments utiles, sous une forme isolée ; des systèmes d'expression SNARK et des dosages utiles pour identifier des substrats SNARK et des modulateurs de l'activité SNARK ainsi que des anticorps utiles en tant que modulateurs SNARK, par exemple dans des applications thérapeutiques permettant de moduler le métabolisme du glucose.
Patent WO-03034911-A3 (WO)
Inventor: LI LUYA
IPC: A61B5/00
Filed: 2002-10-22
Abstract: A detachable sensor assembly for use in monitoring a physiological parameter of a subject includes an information containing circuit and a timer. The sensor assembly stores time varying information in the information containing circuit. The information may include cumulative use times for the detachable sensor assembly and/or for components in the detachable sensor assembly.
Patent WO-9320288-A3 (WO)
Title: Dispositif d'etancheite pour scellement de joints d'expansion coupes dans des barrages en beton et procede d'installation du dispositif
Inventor: SZITA PETER
IPC: E02B7/00
Filed: 1993-03-26
Abstract: Un dispositif d'étanchéité (J) pour scellement d'un joint d'expansion (E) coupé dans un barrage (B) en béton comprend une cellule tubulaire (10) faite d'un matériau élastique et pourvue à ses extrémités supérieure et inférieure respectivement d'un embout supérieur rigide (16) et d'un embout inférieur rigide (20) et arrondi. Deux câbles (36) sont montés entre les embouts supérieur et inférieur (16, 20) pour empêcher l'étirement longitudinal de la cellule (10). La cellule (10) inclut deux renforts (26) longitudinaux espacés l'un par rapport à l'autre et disposés vis-à-vis la coupure pour empêcher la déformation de la cellule (10) dans la coupure. Un espace périphérique continu est défini sur la cellule (10) entre les extrémités inférieures des renforts (26) et l'extrémité supérieure de l'embout inférieur. Des moyens permettent le positionnement et l'installation du dispositif d'étanchéité (J) dans le joint d'expansion (E). Une méthode d'installation du joint d'expansion (E) dans le barrage (B) en béton à l'aide du dispositif d'étanchéité (J) est également proposée, dans laquelle celui-ci est installé dans un trou foré sur le joint d'expansion (E), les renforts (26) étant positionnés dans le sens d'écoulement de l'eau. La cellule (10) est ensuite remplie et mise en tension à l'aide de fluides appropriés. Le joint d'expansion est obtenu par l'achèvement de la coupure.
Patent WO-03063088-A3 (WO)
Inventor: KELLER PHILIP
IPC: G07B15/02
Filed: 2003-01-21
Abstract: According to the inveniton, for toll levying (e.g. in public transport or on toll motorways), users contact a central computer of the provider by means of their mobile telephone or a corresponding mobile appliance which is equipped in such a way that it can acquire data relating to its current position (e.g. from a mobile telephony network), thus initialising an automated dialogue between the mobile appliance and said central computer, and a driving protocol which can be used to levy the toll is opened by the central computer. During the automated dialogue, the central computer transmits combinations of control positions relevant to the current position of the mobile appliance and of a time limit to the mobile appliance, and the mobile appliance transmits its current position and an accordance of said position with one of the control positions or a time-out signal. The central computer continues the automated dialogue at least until the first time-out signal, and then ends the dialogue and closes the driving protocol for the attention of a billing system. The inventive toll levying system can be carried out using already widespread mobile appliances (e.g. mobile telephones) which must only be slightly adapted for levying tolls, and existing mobile telephony networks, and can be used in an unchanged manner for by people transport providers (e.g. public transport) and roadway system providers (e.g. toll motorways) for the levying of tolls.
Patent WO-03104556-A3 (WO)
Title: Process to manufacture an ion-permeable and electrically conducting flat material, the material obtained according to the process, and fuel cells
Inventor: MILLER BALTHASAR
IPC: H01M8/10
Filed: 2003-06-06
Abstract: A fibrous, flat and ion-permeable material made of synthetic fibers, in particular of synthetically spun fibers such as acrylic fibers or aramid fibers, is processed into staple fibers of a specific length and then fibrillated. In a wet-laid inclined machine (paper machine), the fibrillated fibers are formed into a continuous web and then the web or portions of it are subjected to a temperature treatment to make the web electrically conducting by carbonizing/graphitizing the web through heating.
Patent CZ-56194-A3 (CZ)
Title: Derivatives of piperazinyl(sulfonyl) amide of camphor as oxytocin antagonists
Inventor: BOCK MARK G
IPC: C07D233/74
Filed: 1992-08-26
Abstract: Compounds of the formula: <CHEM>  Compounds according to the structural formula, wherein R<1> is     (1) hydrogen,   (2) alkoxycarbonyl or (3) unsubstituted or substituted alkyl wherein said substituent is hydroxyl, alkoxyl, carboxyl, carboxyalkyl., alkylsulfonyl or alkoxycarbonyl; and  R<2> is     (1) hydrogen,   (2) alkoxyl,   (3) aralkoxyl,   (4) alkoxycarbonyl,   (5) alkoxycarbonylamino, (6) unsubstituted or substituted cycloalkyl, wherein said substituent is carboxyl, (7) unsubstituted or substituted phenyl wherein said substituent is one or more of carboxyl, carboxyalkyl or SO3H, (8) unsubstituted or substituted amino, wherein said substituent is unsubstituted or substituted alkyl where said substituent is one or more of carboxyl, alkylsulfonyl or unsubstituted 5-membered heterocyclic rings having 1 or 2 heteroatoms, where said heteroatom is N,   (9) unsubstituted or substituted rings of the formulae <CHEM> where said substituents are one or more of alkyl, carboxyl, carboxyalkyl, carboxyaralkyl, aralkylcarbonyl, aralkoxycarbonyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkoxycarbonylaminoalkylcarbonyl, oxo or unsubstituted or substituted amino wherein said substituent is one or more of alkyl, carboxylalkyl, alkoxycarbonyl or alkoxycarbonylalkyl or (10) unsubstituted or substituted alkyl, wherein said substituent is one or more of hydroxyl, carboxyl, carboxyalkylphenyl, alkylsulfonyl, aminocarbonyl, alkylaminocarbonyl, aralkyl, aralkoxycarbonyl, halogen, alkoxycarbonyl, alkoxycarbonylalkyl, Het or unsubstituted or substituted amino, wherein said substituent is one or more of alkyl, alkylcarbonyl, alkylsulfonyl, carboxyalkyl, Cyc, alkoxycarbonyl, alkoxycarbonylalkyl, aralkoxycarbonyl, aminocarbonylalkyl, alkylaminocarbonyl, phenalkyl or unsubstituted or substituted alkylcarbonyl, where said substituent is a 5-membered heterocyclic ring having 1 or 2 heteroatoms and where said hetero atom is N, where Het is defined as for the above heterocyclic rings and where Cyc is defined as substituted or unsubstituted cycloalkyl wherein said substituent is selected from the group consisting of alkoxycarbonyl, carboxyl, hydroxyl, oxo or spiro-dioxolinyl . Such compounds are oxytocin antagonists useful in the treatment of preterm labor, dysmenorrhea and for the stoppage of labor preparatory to cesarean delivery. r
Patent CU-22791-A3 (CU)
Title: Proceso para la transformación fría de desechos municipales y/o lodo en materiales inertes, planta para llevar a cabo dicho proceso y productos obtenidos
Inventor: BERNABEI RAFFAELLO
IPC: B09B3/00
Filed: 1999-11-05
Abstract: La invención se relaciona con el proceso par la transformación en frío de desechos sólidos urbanos y/o lodos para formar materiales inertes, que comprende los pasos de: -alimentar los desechos sólidos urbanos y/o lodos desde líneas de alimentación respectivas; -introducir materiales dentro de un micronizador con objeto de reducir la granulometría y recuperar el agua contenida en ellos; -anadir CaO en una cantidad de entre 5 y 10% en peso del componente principal; -anadir CaCO3 en una cantidad de entre 5 y 10% en peso del componente principal; -anadir un aditivo polimérico en una cantidad de entre 3 y 10% en peso del componente principal; -transportar el producto haccia el paso de conformación y almacenaje. La invención se relaciona también con una planta para la realización del proceso anterior y para los productos obtenidos.
Patent CZ-2000173-A3 (CZ)
Title: Medicament for treating diabetes mellitus and states connected with diabetes mellitus as well as pharmaceutical preparation for oral administration
Inventor: BUCKINGHAM ROBIN EDWIN
IPC: A61K45/06
Filed: 1998-07-16
Abstract: A method for the treatment of diabetes mellitus and conditions associated with diabetes mellitus in a mammal, which method comprises administering an effective non-toxic and pharmaceutically acceptable amount of an insulin sensitiser and a sub-maximal amount of an insulin secretagogue, to a mammal in need thereof; and a pharmaceutical composition for use in such method.