Patent SG-11201805136T-A (SG)
Title: Group b adenovirus encoding an anti-tcr-complex antibody or fragment
Inventor: CHAMPION BRIAN ROBERT
IPC: A61K35/761
Filed: 2016-12-19
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101011111001011111101101111101111011111 International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/103290 Al 22 June 2017(22.06.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 35/761 (2015.01) C07K 16/28 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 35/768 (2015.01) A61P 35/00 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/EP2016/081817 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 19 December 2016 (19.12.2016) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 1522334.0 17 December 2015 (17.12.2015) GB (84) Designated States (unless otherwise indicated, for every 1607463.5 29 April 2016 (29.04.2016) GB kind of regional protection available): ARIPO (BW, GH, 1617207.4 10 October 2016 (10.10.2016) GB GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 1617206.6 10 October 2016 (10.10.2016) GB TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (71) Applicant: PSIOXUS THERAPEUTICS LIMITED DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, [GB/GB]; 154B Milton Park, Abingdon Oxfordshire OX14 LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, 4SD (GB). SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (72) Inventors: CHAMPION, Brian Robert; 154B Brook GW, KM, ML, MR, NE, SN, TD, TG). Drive, Milton Park, Hertfordshire, Abingdon Oxfordshire Published: OX14 4SD (GB). BROWN, Alice Claire Noel; 154B with international search report (Art. 21(3)) Oxfordshire OX14 Brook Drive, Milton Park, Abingdon 4SD (GB). — with sequence listing of description (Rule 5.2(a)) part — (74) Agents: STERLING IP et al.; Orion House, Bessemer Road, Welwyn Garden City Hertfordshire AL7 1HH (GB). 1-1 © tz\ ei M © ,-1 (54) Title: GROUP B ADENOVIRUS ENCODING AN ANTI-TCR-COMPLEX ANTIBODY OR FRAGMENT 1-1 C (57) : The present disclosure relates to a replication deficient oncolytic viral vector or replication capable group B oncolytic N adenovirus selected from the group consisting of Adl 1 and enadenotucirev, wherein the virus encodes an antibody or a binding frag - O ment thereof for expression on the surface of a cancer cell, wherein said antibody or binding fragment is specific to a CD3 protein of a T-cell receptor complex (TCR), wherein the virus does not encode a B7 protein or an active fragment thereof, pharmaceutical com- positions comprising the same, and use of any one of the same in treatment, particularly in the treatment of cancer.