Patent SG-11201810171S-A (SG)
Title: Kras g12c inhibitors
Inventor: FISCHER JOHN
IPC: A61K31/445
Filed: 2017-05-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111111111101110111111111111111111111111111111111111111110111111111111111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/201161 Al 23 November 2017 (23.11.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every CO7D 231/56 (2006.01) A61K 31/445 (2006.01) kind of national protection available): AE, AG, AL, AM, CO7D 295/185 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (21) International Application Number: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, PCT/US2017/033099 DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (22) International Filing Date: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, 17 May 2017 (17.05.2017) MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (25) Filing Language: English SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (26) Publication Language: English TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 62/338,116 18 May 2016 (18.05.2016) US kind of regional protection available): ARIPO (BW, GH, 62/444,614 10 January 2017 (10.01.2017) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (71) Applicants: MIRATI THERAPEUTICS, INC. [US/US]; TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 9393 Towne Centre Dr., Suite 200, San Diego, CA 92121 EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (US). ARRAY BIOPHARMA, INC. [US/US]; 3200 Wal- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, nut St., Boulder, CO 80301 (US). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (72) Inventors: FISCHER, John, P.; c/o Array Biopharma, KM, ML, MR, NE, SN, TD, TG). _ Inc., 3200 Walnut St., Boulder, CO 80301 (US). FELL, Jay, Bradford; c/o Array Biopharma, Inc., 3200 Walnut Published: = St., Boulder, CO 80301 (US). BLAKE, James, F.; c/o Ar- — with international search report (Art. 2 I (3)) ray Biopharma, Inc., 3200 Walnut St., Boulder, CO 80301 = _ (US). HINKLIN, Ronald, Jay; c/o Array Biopharma, Inc., 3200 Walnut St., Boulder, CO 80301 (US). MEJIA, = Macedonio, J.; c/o Array Biopharma, Inc, 3200 Walnut = _ St., Boulder, CO 80301 (US). HICKEN, Erik, James; c/ = o Array Biopharma, Inc, 3200 Walnut St., Boulder, CO _ 80301 (US). CHICARELLI, Mark, Joseph; c/o Array Biopharma, Inc, 3200 Walnut St., Boulder, CO 80301 (US). — = GAUDINO, John, J.; c/o Array Biopharma, Inc, 3200 Wal- nut St., Boulder, CO 80301 (US). VIGERS, Guy, P.A.; c/o Array Biopharma, Inc, 3200 Walnut St., Boulder, CO = = = 80301 (US). BURGESS, Laurence, E.; c/o Array Bio- pharma, Inc, 3200 Walnut St., Boulder, CO 80301 (US). = MARX, Matthew, Arnold; c/o Mirati Therapeutics, Inc., 9393 Towne Centre Dr., Suite 200, San Diego, CA 92121 = (US). CHRISTENSEN, James, Gail; c/o Mirati Therapeu- = tics, Inc., 9393 Towne Centre Dr., Suite 200, San Diego, CA = — 92121 (US). LEE, Matthew, Randolf; c/o Mirati Thera- = peutics, Inc., 9393 Towne Centre Dr., Suite 200, San Diego, = CA 92121 (US). SAVECHENKOV, Pavel; c/o Array Bio- pharma, Inc., 3200 Walnut St., Boulder, CO 80301 (US). ZECCA, Henry, J.; c/o Array Biopharma, Inc., 3200 Wal- nut St., Boulder, CO 80301 (US). 1-1 .. (74) Agent: POLYAKOV, Mark, V. et al.; Wood, Phillips, Katz, Clark & Mortimer, 500 West Madison Street, Suite 1-1 1130, Chicago, IL 60661 (US). 1-1 1-1 0 ei IN (54) Title: KRAS G12C INHIBITORS 1-1 0 (57) : The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to ei compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods O of use therefor.