baber/WOPTO huggingface dataset:
Patent AU-2021221398-B2 (AU)
Title: Nuclear transport modulators and uses thereof
Inventor: SANDANAYAKA VINCENT P
IPC: C07D249/08
Filed: 2021-08-23
Granted: 2023-08-17
Abstract: OF THE DISCLOSURE 
The present invention relates to compounds of formula I: 
N-N NH R2 
F3C / O N4 
N R1  R3 
CF3 
and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the 
compounds of formula I, and methods of using said compounds, salts and compositions in the 
treatment of various disorders associated with CRM1 activity.
Patent AU-2022200643-B2 (AU)
Title: Listeria-based compositions comprising a peptide minigene expression system and methods of use thereof
Inventor: PETIT ROBERT
IPC: C12N15/74
Filed: 2022-02-01
Granted: 2022-06-02
Abstract: This disclosure provides compositions, including Listeria delivery vectors comprising 
minigene expression constructs, and methods of using the same for inducing an immune response 
against an antigen-expressing tumor and for treating the same, and vaccinating against the same in 
subjects bearing the tumors.
Patent AU-2022209221-B2 (AU)
Title: Controlled-release CNP agonists with increased NEP stability
Inventor: SPROGØE KENNETT
IPC: A61K47/50
Filed: 2022-07-26
Granted: 2023-12-14
Abstract: The present invention relates to controlled-release CNP agonists having an at least 5-fold 
longer degradation half-life in an in vitro NEP degradation assay than the corresponding 
released CNP agonist, to pharmaceutical compositions comprising said controlled-release CNP 
agonist, their use and to methods of treatment.
Patent JP-3827918-B2 (JP)
IPC: B41J2/01
Filed: 2000-05-24
Granted: 2006-09-27
Abstract: PROBLEM TO BE SOLVED: To provide an image processor in which the saving quantity of recording agent can be regulated for each image region. SOLUTION: The image processor comprises a section 13a for separating an image into a plurality of regions based on image data, a saving section 13f for regulating the image data for each region in order to alter consumption of recording agent, a region separation accumulating section 15g for recognizing the number of pixels in each region based on the image data, a recording agent consumption calculating section 15e for recognizing the residual quantity of recording agent at an imaging section 14, a saving information storing section 15h having a plurality of regulation modes indicative of the regulating method of image data for each region at the saving section 13f,  and a recordable number of sheets predicting section 15c for predicting the number of times of forming the image using the residual quantity of recording agent for each regulation mode when the image data of a relevant image is regulated by applying each regulation mode based on each regulation mode and the number of pixels in each region of the image.
Patent JP-3614099-B2 (JP)
IPC: H01L23/12
Filed: 2000-10-10
Granted: 2005-01-26
Abstract: PROBLEM TO BE SOLVED: To provide a semiconductor device for securing electrical conduction from a side surface. SOLUTION: A plurality of layers of protection films 20A and 20B are provided on an active element formation surface 18 of a semiconductor chip 10. The protective films 20A and 20B are formed by a polyamide resin and are flexible. Terminals 14A and 14B, that are electrically connected onto electrode pads 12A and 12B, are provided separately from the active element formation surface 18. The terminals 14A and 14B are exposed from side surfaces 28A and 28B of the protective films 20A and 20B.
Patent JP-3710373-B2 (JP)
IPC: F42B3/12
Filed: 2000-11-06
Granted: 2005-10-26
Abstract: The initiator consists of a fragmenting container with two electrode pins for connecting to an electrical circuit (18) made from metal layers on an insulating support (16). The circuit incorporates a flat heating resistance (17) connected to the electrodes by metal layer conductors (28, 29), with both conductors and the resistance covered by a pyrotechnic initiation compound. The first metal layer is of a nickel/chrome alloy and apart from heating resistance has curved edges, while the second layer is of copper and covers the first layer except for the resistance.
Patent JP-3642729-B2 (JP)
IPC: B65G49/07
Filed: 2000-11-27
Granted: 2005-04-27
Abstract: PROBLEM TO BE SOLVED: To provide a processing apparatus that can be applied to an overhead transfer apparatus and enables a batch process. SOLUTION: In a processing apparatus comprising a housing 1 that has a carry in/out entrance 6 where a container 2 with a cover, a plurality of objects w accommodated in a sealing state, is carried in and out, a transport storing region Sa provided in the housing 1 that has a transport mechanism 11 for transporting the container 2 and a storing stack 8 for storing several containers 2, and a process region Sb where the object w are taken out of the container 2 and a prescribed process is performed, a mount stage 7 for placing the container 2 is provided outside the entrance 6, and a moving mechanism 10 that can move the container 2 to a delivered position to the transport mechanism 11 is provided on the mount stage 7.
Patent JP-3476773-B2 (JP)
IPC: G01N7/14
Filed: 1998-07-10
Granted: 2003-12-10
Abstract: This invention relates to a measuring apparatus for measuring the gas loading of a liquid, comprising a measuring device which substantially consists of a piston pump, by means of which a sample quantity of the liquid is subjected to a reduced pressure in a measuring cylinder chamber and the dissolved amount of gas is thereby desorbed and can be determined via the gas law by changing the conditions of pressure and/or temperature in the cylinder chamber. The measuring apparatus is of particularly compact construction and for this purpose is provided with a servomotor as an actuating drive for the piston pump, which servomotor not only enables the reduced pressure to be generated in the measuring chamber but also ensures the return of the measured test sample from the measuring cylinder chamber after the measuring operation. Preferably, the measuring apparatus is provided with an ultrasonic generator by means of which the test sample is acoustically irradiated and the time of desorption for expelling the gas is thus considerably shortened.
Patent JP-3851772-B2 (JP)
IPC: B27K7/00
Filed: 1998-05-26
Granted: 2006-11-29
Abstract: A process for treating linenized cork sheets, employing at least one emollient agent comprising surfactants, allows the obtainment of crease-resisting sheets that can be folded like fabric and comprises the steps of diluting said at least one emollient agent with water, in a predetermined proportion water/emollient agent, obtaining an emollient mixture; preparing an absorbing layer sheet, to be soaked with liquid, and inducing the absorption of said emollient mixture in said layer; putting in contact said soaked layer (1) with a linenized cork sheet (2) at its linenized surface (3), keeping this contact for more than 24 hours.
Patent JP-4004229-B2 (JP)
IPC: H04B1/7073
Filed: 1999-01-27
Granted: 2007-11-07
Abstract: The present invention relates to a receiver for receiving at least one of a plurality of channels in a communication system, the receiver comprising:  an adaptive matched filter (79) for receiving communication signals and producing a filtered signal by using a weighting signal; a rake receiver (101) for receiving communication signals and a pseudo-noise signal (931) generated for a selected channel and producing a filter weighting signal; means for defining the filter weighting signal with a correction signal (119), said correction signal to produce the weighting signal used by said adaptive matched filter; a channel despreader (85) for said selected channel coupled to said adaptive matched filter output for despreading said filtered signal using the pseudo-noise signal generated for said selected channel to produce a despread channel signal (95) of said selected channel; a pilot channel despreader (87) for a pilot channel coupled to said adaptive matched filter output for despreading said filtered signal using a pseudo-noise signal generated for said pilot channel to produce a despread pilot signal (135) of said pilot channel; a hard decision processor (121) in association with a complex conjugate processor (123) for receiving the despread channel signal of said selected channel and producing said correction signal; and means (157) for producing a phase correction signal (183) utilizing at least said despread pilot signal, said phase correction signal being applied to produce phase-corrected channel signals.  <IMAGE>
Patent JP-4340009-B2 (JP)
IPC: G06K19/04
Filed: 1999-06-14
Granted: 2009-10-07
Abstract: A data carrier for noncontacting control of persons with nontransferable entitlement to utilize a service is integrated into a bracelet (1) so as to be useless after the bracelet (1) is opened.
Patent JP-4421113-B2 (JP)
IPC: A61M35/00
Filed: 1999-08-18
Granted: 2010-02-24
Abstract: A planar disposable transdermal iontophoretic delivery system is disclosed which includes amounts of an oxidizable species and a reducible species connected by a common conductor forming a galvanic battery for serving as the sole source of power and control for the system, an amount of a therapeutic agent is provided to be driven through the skin of a patient solely through the use of the galvanic battery. The galvanic battery is provided with a lot-tested coulombic capacity rating to predict dosage.
Patent JP-4838937-B2 (JP)
IPC: C12Q1/6841
Filed: 1999-12-03
Granted: 2011-12-14
Abstract: The invention provides methods and means for generating interstrand cross-links in nucleic acid at certain specific locations in said nucleic acid. Said certain specific locations in said nucleic acid can be selected from other locations through hybridising nucleic acid present in said selected location with complementary nucleic. In one aspect the invention provides a method for providing at least one selected sequence in a nucleic acid with interstrand cross-links comprising hybridising at least one selected single strand sequence with a complementary single strand nucleic acid wherein said selected sequence or said complementary nucleic acid or both comprise a cross-linking agent. The means and methods of the invention may be used in and beneficial for a wide variety of applications, such as the generation of nucleic acid probes and the treatment of diseases such as cancer.
Patent JP-4523170-B2 (JP)
IPC: C08G65/26
Filed: 2000-01-31
Granted: 2010-08-11
Abstract: The invention provides new double metal cyanide (DMC) catalysts for preparing polyetherpolyols by the polyaddition of alkylene oxides to starter compounds which contain active hydrogen atoms, wherein the catalyst comprises a) double metal cyanide compounds, b) bile acids or their salts, esters or amides and c) organic complex ligands. The catalysts according to the invention show greatly increased activity during preparation of a polyetherpolyol.
Patent JP-4622105-B2 (JP)
IPC: F16D51/48
Filed: 2001-01-29
Granted: 2011-02-02
Abstract: The present invention to provides a drum brake that generates the same braking force when a vehicle moves forward and backward. A first lever is connected to a second lever by a strut. A fourth lever provided with an anchor member and a third lever for connecting the fourth lever and the first lever to the end of the fourth lever) opposite to the anchor member across a screw which is the center of swing of the fourth lever. Accordingly, when the vehicle moves forward, an anchor load is received by the anchor member and the second lever. When the vehicle moves backward, the anchor load is received by the anchor member and the first lever.
Patent JP-4755357-B2 (JP)
IPC: F16H1/32
Filed: 2001-04-18
Granted: 2011-08-24
Abstract: A reduction gear which facilitates the mounting of a motor while securing a hollow space in a portion of the rotation center of the reduction gear, and which makes it possible to easily change the reduction ratio. A hollow space is formed in a portion of the rotation center of a reduction gear, a motor mounting member (24) for maintaining a distance between the center of rotation and a rotating shaft of the motor to a fixed distance, and a front-stage reducing portion (32) for reducing the output rotation of the motor is provided between the center of rotation and the rotating shaft of the motor.
Patent JP-4698890-B2 (JP)
IPC: B21D22/14
Filed: 2001-06-29
Granted: 2011-06-08
Abstract: A revolution center line (C) of a roll (R) is made eccentric with respect to an axis (L) of an elliptic tube (1). The eccentric amount  epsilon  is set such that when the revolution radius of the roll (R) is gradually reduced from a state in which the roll (R) is not in contact with any part of the elliptic tube (1), the roll (R) contacts one (4) of the two protuberances (4, 4) which is located on the opposite side to the eccentric direction generally earlier than any other part of the eccentric tube (1). The roll (R) is revolved and reciprocally moved in a direction of the revolution center line (C). At least at one end portion of the reciprocal movement, the roll (R) is moved towards the revolution center line (C) side. By repeating this procedure, the roll (R) is press contacted with the first-mentioned protuberance (4) so as to crush it for elimination. <IMAGE>
Patent JP-4822628-B2 (JP)
IPC: C08F220/10
Filed: 2001-08-06
Granted: 2011-11-24
Abstract: Cationic fine particulate polymer dispersion is prepared by polymerization of a monomer mixture comprising (wt.%): (A) optionally substituted styrene (20-60); (B) 1-18C (meth)acrylic acid ester (40-80); and (C) non-ionic ethylenically unsaturated monomers different to (A) and (B) (0-20). The polymerization takes place in the presence of an aqueous polymer dispersion. Cationic fine particulate polymer dispersion (I) is prepared by polymerization of a monomer mixture comprising: (A) 20-60 wt.% of an optionally substituted styrene; (B) 40-80 wt.% of a 1-18C (meth)acrylic acid ester; and (C) 0-20 wt.% of non-ionic ethylenically unsaturated monomers different to (A) and (B) (where the sum of (A), (B) and (C) is 100 wt.%). The polymerization takes place in the presence of an aqueous polymer dispersion prepared by solution polymerization of a monomer mixture comprising (D), (E) and (F) in a saturated 1-6C carboxylic acid whereby the mixture comprises (D) 15-35 wt.% of a (meth)acrylic acid ester and/or (meth)acrylamide containing a tertiary amine group (E) 65-85 wt.% of an optionally substituted styrene and (F) 0-20 wt.% of a non-ionic or cationic ethylenically unsaturated monomer different to (D) and (E) where the sum of (D), (E) and (F) is 100%.
Patent JP-3957047-B2 (JP)
IPC: A61F5/44
Filed: 2001-08-23
Granted: 2007-08-08
Abstract: A pants-type disposable diaper 1A basically comprises pants 2 and a liquid-absorbent pad 3 laid on an inner surface of the pants 2. The pad 3 is contoured by longitudinally opposite end portions 3a bonded to the pants 2 in the vicinity of waist-hole's peripheral edge portions 9 of the pants 2 and transversely opposite side edge portions 3b extending across a crotch region 7 of the pants 2 toward the waist-hole's peripheral edge portions 9 in a longitudinal direction. First and second stretchable elastic members 23, 24 extending in the longitudinal direction are bonded in a stretched state to an outer surface of a backsheet 19 forms the pad 3 so that the area of the pad 3 defined between the longitudinally opposite end portions 3a thereof is lifted off from the inner surface of the pants as these elastic members 23, 24 contact.
Patent JP-3843840-B2 (JP)
IPC: G03F7/004
Filed: 2001-12-28
Granted: 2006-11-08
Abstract: <P>PROBLEM TO BE SOLVED: To provide a radiation-sensitive resin composition excellent in basic physical properties as a resist, such as transparency and sensitivity to radiations, resolution and dry etching resistance.  <P>SOLUTION: The radiation-sensitive resin composition comprises an acid- dissociable group-containing resin (A) including a repeating unit of formula (1-1) (where each R<SP>1</SP>is independently H or methyl and each R<SP>2</SP>is independently a 2-6C alkyl) and a radiation-sensitive acid generator (B) of formula (2) (where R<SP>3</SP>is a monovalent organic group and R<SP>4</SP>is a divalent organic group).  <P>COPYRIGHT: (C)2003,JPO
Patent JP-4255637-B2 (JP)
IPC: A61L2/20
Filed: 2000-09-20
Granted: 2009-04-15
Abstract: An apparatus for sterilizing a sealable enclosure includes a circuit for flow of a sterilizing gas or gasses. The circuit is connected to the enclosure to be sterilized to form a closed circuit and pumps to circulate gas through the circuit and enclosure. The circuit has parallel branches one of which contains apparatus to deactivate a sterilant to be added to the carrier gas flowing through the circuit and apparatus to dehumidify the gas. The other branch contains apparatus to heat the gas and apparatus to supply a sterilant vapor or vapors to the gas. Control apparatus determines which of the parallel branches the gas flows through. The control apparatus maintains flow through one branch passage until the relative humidity falls below a predetermined level. The flow through that branch is then terminated and flow through the other branch initiated.
Patent JP-4582566-B2 (JP)
IPC: D01F9/16
Filed: 2000-12-05
Granted: 2010-11-17
Abstract: The carbonization of cellulose fiber fabric comprises an initial stage of heat treatment up to 250° C. to 350° C., with a relatively high mean temperature rise speed of 10° C./min to 60° C./min, an intermediate stage up to 350° C. to 500° C. with a lower mean temperature rise speed of 2° C./min to 10° C./min, and a final stage up to 500° C. to 750° C. with a mean temperature rise speed that is again raised to 5° C./min to 40° C./min.
Patent JP-4516712-B2 (JP)
IPC: C12N15/09
Filed: 2000-12-22
Granted: 2010-08-04
Abstract: Producing L-pipecolic acid comprises reducing delta-1-piperidine-6-carboxylic acid with pyrrolidine-5-carboxylate reductase. Independent claims are also included for the following: (i) a recombinant Escherichia coli or coryneform bacterium that can express a gene encoding lysine-6-aminotransferase; and (ii) producing L-pipecolic acid by culturing the recombinant Escherichia coli or coryneform bacteria in a L-lysine-containing medium to accumulate the product for isolation.
Patent JP-4936626-B2 (JP)
IPC: C12N5/09
Filed: 2001-02-07
Granted: 2012-05-23
Abstract: A pharmaceutical preparation, comprising a cell-cycle regulatory protein, and/or a nucleic acid encoding that protein, for immunization against carcinoma and its preliminary stages, is new. - ACTIVITY : Cytostatic. Peripheral blood lymphocytes were isolated from an HLA-A0201 positive sample by density centrifugation and T lymphocytes were separated from monocytes and B lymphocytes using antibodies coupled to magnetic beads (CD11, CD16, CD19, CD36 and CD56) (T cell isolation kit, Milteny, Germany). Peptides of p16 were identified using a software system (NIH bioinformation service) including the following peptides ValMetMetMetGlySerAlaArgVal, ValLeuHisArgAlaGlyAlaArgLeu, TheLeuThrArgProValHisAspAla, LeuLeuHisGlyAlaGluProAsnCys, SerMetGluProSerAlaAspMetLeu, MetMetGlySerAlaArgValAlaGluLeu, LeuLeuLeuHisGlyAlaGluProAsnCys, GlyValMetMetMetGlySerAlaArgVal. The isolated T cells were incubated with T2 cells and a mixture of the 9mer (a) or 10mer (b) peptides. The T cells were re-stimulated weekly over a six week period. In each case 10 7> T-cells were co-cultivated with 2x10 6> peptide-loaded T2 cells in 24 well plates. Reaction against the peptide-loaded T2 cells was determined weekly using an interferon (IFN)-lambda enzyme linked immunosorbent assay (ELISA). On day 28 reaction against mixture (a) was observed with the main reaction being against peptide ValMetMetMetGlySerAlaArgVal (1000 specific cells per million cells), and a weaker reaction against mixture (b) with peptide MetMetGlySerAlaArgValAlaGluLeu being the highest (600 specific cells per million cells). Thus it is clear that CD8 +> T-cells can be stimulated against p16. These activated T-cells were incubated with human leukocyte antigen (HLA) A0201+ Caski cervix carcinoma cells which over-express p16, and with colon carcinoma line SW480 which do not over-express p16. The Caski cells were lysed, whilst the controls were not. - MECHANISM OF ACTION : Vaccine; gene therapy.
Patent JP-4871478-B2 (JP)
IPC: A61K8/44
Filed: 2001-03-01
Granted: 2012-02-08
Abstract: The invention relates to a plurality of liquid cleansing compositions having at least one lamellar phase which possesses a lotion-like appearance conveying signals of enhanced moisturization and at least one abutting isotropic phase having enhanced cleansing ability. The inventive composition is contained in a partitionless container in one embodiment conveying signals of a plurality of compositions. This multiphase composition is stable upon storage and is dispensed as a striped product where typically one stripe has primarily a cleansing function and a second stripe has primarily a moisturization function.
Patent JP-4828075-B2 (JP)
IPC: H01L21/336
Filed: 2001-04-06
Granted: 2011-11-30
Abstract: In a semiconductor package for a chip having terminals on both sides, for example, a power MOSFET in which the gate and source terminals are on the front side and the drain terminal is on the back side, electrical contact is made with the back side terminal by extending vias, which can take the form of trenches, holes or other cavities, either entirely or patrially through the chip. The vias are filled with a metal or other electrically conductive material. The process is performed on the chips in a wafer simultaneously. The resulting package is compact and economical to manufacture and can readily be mounted, flip-chip style, on a printed circuit board.
Patent JP-4921680-B2 (JP)
IPC: B60T8/00
Filed: 2001-05-30
Granted: 2012-04-25
Abstract: The general principle underlying the invention is a braking system that is provided with an arithmetic unit with at least two independent channels for determining the reference speeds approximated to the actual vehicle speed. The at least two determined reference speeds are used only for regulating a part of the brakes installed in the vehicle.
Patent JP-4040364-B2 (JP)
IPC: F21Y103/00
Filed: 2002-05-23
Granted: 2008-01-30
Abstract: There is provided a surface light-emitting device capable of preventing an increase in power consumption even if the length of the light-emitting surface of the surface light-emitting device is greater than the width, and capable of emitting light uniformly without decreasing the brightness of the light-emitting surface nor increasing the height of the light guiding space. In the present surface light-emitting device, the incident plane (201) is one of two sides of the light guiding space (20) in opposition in the longitudinal direction. The light-transmitting plate (4) includes a diffusion filter (6) which covers a specific area of the surface of the light-transmitting plate (4) near the light source (3). The remaining area of the surface of the light-transmitting plate at a distance from the light source (3) is not covered with the diffusion filter (6). The diffusion filter (6) is formed of a laminate in which a plurality of diffuse transmission films are layered. The number of diffuse transmission film (6) layers is highest in the area closest to the light source (3) so that the light transmittance is increased as the distance from the light source (3) increases due to a decrease in the diffusion of light, and the number is gradually decreased as the distance from the light source (3) increases.
Patent JP-4713053-B2 (JP)
IPC: A61K38/00
Filed: 2002-07-25
Granted: 2011-06-29
Abstract: A method for producing an antihypertensive agent containing an effective amount of dipeptide Tyr-Pro and/or a pharmaceutically acceptable salt thereof, the effective amount being from 0.05 to 10mg/kg body weight/day.