baber/WOPTO huggingface dataset:
Patent EA-003057-B1 (EA)
Title: Method for the preparation of 5-cyanophthalide
Inventor: PETERSEN HANS
IPC: C07D307/88
Filed: 1999-12-22
Abstract: 1. A method for the preparation of 5-cyanophthalide and 5-carboxyphthalide comprising a) conversion of 5-carboxyphthalide to an amide of Formula IV   in which R is hydrogen or C1-6 alkyl, and b) then reacting the amide of Formula IV with a dehydrating agent thereby obtaining 5-cyanophthalide   2. The method of Claim 1 wherein the conversion of 5-carboxyphthalide to the amide of Formula IV is carried out via an ester of Formula VI:   wherein R1 is C1-6 alkyl or phenyl, by treatment of 5-carboxyphthalide with an alcohol R1OH in the presence of an acid and subsequent amidation of the ester of formula VI with ammonia or an C1-6 alkylamine. 3. The method of Claim 1 wherein the conversion of 5-carboxyphthalide to the amide of Formula IV is carried out via chloroanhydride of Formula VII:   by treatment of 5-carboxyphthalide with POCl3, PCl3 or SOCl3 and subsequent amidation of chloroanhydride of formula VII with ammonia or an C1-6 alkylamine. 4. The method of Claim 1 wherein the conversion of 5-carboxyphthalide to the amide of Formula IV is carried but via an chloroanhydride of Formula VII and an ester of Formula VI:                                     wherein R1 is C1-6 alkyl or phenyl, by treatment of 5-carboxyphthalide with POCl3, PCl3 or SOCl3, with further reacting of thus obtained chloroanhydride of Formula VII with an alcohol R1OH and performing amidation of the ester of Formula VI with ammonia or an C1-6 alkylamine. 5. The method of Claim 2 wherein the acid used is a mineral acid or a Lewis acid, preferably HCl, H2SO4, POCl3, PCl3, SOCl3. 6. The method of Claim 2, 4 or 5 wherein R1 is methyl or ethyl. 7. The method of any of Claims 1-6 in which the dehydrating agent used in step b) is SOCl3, POCl3 and PCl3, preferably SOCl3. 8. The method of any of Claims 1-7 wherein the reaction in step b) is carried out neat or in a suitable solvent, such as toluene, sulfolan or acetonitrile, preferably in toluene. 9. The method of any of Claim 8 wherein the dehydrating agent used in step b) is SOCl2 and the reaction is carried out in toluene comprising a catalytic amount of N,N-dimethylformamide. 10. The method of any of Claims 1-9 wherein R is H or tert-butyl. 11. The method of Claim 2, wherein the 5-carboxyphthalide of Formula III is reacted with an alcohol R1OH, preferably ethanol or methanol, in the presence of POCl3, in order to obtain an ester of Formula VI, which is then reacted with ammonia, thereby giving 5-carbamoylphthalide, which in turn is reacted with SOCl2 to 5-cyanophthalide. 12. The method of Claim 11, wherein the 5-carboxyphthalide of Formula III is reacted with ethanol in the presence of POCl3, in order to obtain the ethyl ester of Formula VI, which is then reacted with ammonia in methanol, thereby giving 5-carbamoylphthalide, which in turn is reacted with SOCl2 to 5-cyanophthalide.
Patent EA-008907-B1 (EA)
Title: Indole derivatives
Inventor: ZISAPEL NAVA
IPC: A61K31/42
Filed: 2000-05-24
Abstract: The invention relates to indole derivatives of general formulaand their acid addition salts, wherein A is Calkylene, X is > CH, > or >C=O, and the other symbols have various defined values, and also relates to pharmaceutical, skin-protective and cosmetic compositions which comprise them.
Patent EA-008087-B1 (EA)
Title: Liquid pharmaceutical compositions
Inventor: KULKARNI NEEMA MAHESH
IPC: A61K47/10
Filed: 2002-04-29
Abstract: A liquid pharmaceutical composition of a GABA analog comprising at least one polyhydric alcohol containing 2 to 6 carbon atoms having a pH of about 5.5 to about 7.0 and additionally a two-component liquid pharmaceutical composition comprising a first component comprising a powder mixture comprising a GABA analog and a solid polyhydric alcohol, and a second component comprising a liquid base are described, as well as methods to prepare the compositions and a method for treating cerebral diseases, including epilepsy, faintness attacks, hypokinesia and cranial traumas, neurodegenerative disorders, depression, mania and bipolar disorders, anxiety, panic, inflammation, renal colic, insomnia, gastrointestinal damage, incontinence, pain, including neuropathic pain, muscular pain, skeletal pain, and migraine using a therapeutically effective amount of the pharmaceutical compositions.
Patent EA-010294-B1 (EA)
Title: Compositions of lipopeptide antibiotic derivatives and methods of use thereof
Inventor: CAMERON DALE R
IPC: C07K7/64
Filed: 2004-06-28
Abstract: The present invention provides derivatives of lipopeptide antibiotics that display antimicrobial activity against microorganisms, methods and compounds for synthesizing such antimicrobial derivatives and analogues, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of microbial infections.
Patent EA-012249-B1 (EA)
Title: Configuration and a method for gas condensate separation from high-pressure hydrocarbon mixtures
Inventor: MAK JOHN
IPC: F25J3/00
Filed: 2005-06-22
Abstract: A gas condensate production plant comprises a plurality of separation units in which Cand/or Cand lighter components are stripped from the separator feeds using compressed heated stripping vapor produced from the feed in respective downstream separation units. Contemplated plants substantially reduce heating and cooling duties by using the waste heat from the compressor discharges in the separation process. Furthermore, the multi-stage fractionation according to the inventive subject matter provides improved gas condensate recovery at reduced energy costs. The invention also relates to a corresponding method for production of the gas condensate.
Patent EA-014138-B1 (EA)
Title: Electrochemical reduction of metal oxides
Inventor: RATCHEV IVAN
IPC: C22B9/14
Filed: 2006-08-01
Abstract: A process for electrochemically reducing a titanium oxide in a solid state in an electrolytic cell that includes an anode, a cathode, a molten CaCl2-based electrolyte containing CaO, and titanium oxide feed material in contact with the molten electrolyte is disclosed. The process is characterised by controlling the process by controlling the concentration of CaO in the electrolyte.
Patent EA-014648-B1 (EA)
Title: Method of detecting pathogens
Inventor: JENEY CSABA
IPC: C12Q1/68
Filed: 2006-11-15
Abstract: A method for detecting pathogens, particularly organisms associated with sexually transmitted diseases, especially Human papilloma virus genotypes is described. The method involves the use of real-time PCR using specially designed probes. The probes, kits for carrying out the method, and methods for designing primers suitable for use in the method of the invention are also described.
Patent EA-014247-B1 (EA)
Title: Process for industrial synthesis of strontium ranelate and its hydrates
Inventor: VAYSSE-LUDOT LOCILE
IPC: A61K31/381
Filed: 2008-09-25
Abstract: A process for the industrial synthesis of strontium ranelate of formula (I)and its hydrates.
Patent EA-021903-B1 (EA)
Title: Arrangement, use of an arrangement, device, snow lance and method for producing ice nuclei and artificial snow
Inventor: LEHNER DANIELA
IPC: F25C3/04
Filed: 2008-07-08
Abstract: A nucleator nozzle (20) for producing ice nuclei is designed as convergent-divergent nozzle. The nozzle channel (25) has a section (27) that is widening. The ratio of the cross-sectional area of the outlet opening (23) to the cross-sectional area of the nozzle channel (25) in the region of the nucleus diameter (26) is at least approximately 4:1. A snow lance (1) having at least one nucleator nozzle (20) and having at least one water nozzle (30; 30') is designed such that water droplets (32) produced by the water nozzle (30; 30') pass through a droplet path (31; 31') of at least 20 cm until they reach ice nuclei (28) from the nucleator nozzle (20) in a germination zone E.
Patent EA-016973-B1 (EA)
Title: Method for selectively dissolving sandstone formations
Inventor: COUILLET ISABELLE
IPC: C09K8/72
Filed: 2008-05-19
Abstract: In a method of treating a sandstone-containing subterranean formation penetrated by a wellbore, a slurry of a carrier fluid containing a surface modification agent of at least one of a hydrolyzable organosilicon compound, a phosphonate compound or a combination of these is formed. The slurry is introduced into the wellbore at or above the fracture pressure of the formation. A sandstone-dissolving material is introduced into the wellbore with or subsequent to introduction of the slurry. The surface modification agent may be encapsulated within an encapsulating material. A composition for use in treating sandstone-containing subterranean formations is also provided. The composition includes an aqueous carrier fluid containing an encapsulated surface modification agent of at least one of a hydrolysable organosilicon compound and a phosphonate compound that is encapsulated within an encapsulating material.
Patent EA-018610-B1 (EA)
Title: Method and system for steering a directional drilling system
Inventor: SHEPPARD MICHAEL
IPC: E21B7/06
Filed: 2008-08-12
Abstract: A drill bit direction system and method is disclosed that modifies or biases the stochastic movement of the drill bit to change a drilling direction of a drilling system. The direction of the drill bit is monitored to determine if the direction happens to align in some way with a preferred direction. If the direction is not close enough to a preferred or desired direction, stochastic motion of the drill bit in the borehole may be controlled and/or motion of the drill bit under a side force acting on the drill bit to direct the drilling may be focused or biased to modify the direction of drilling closer to the preferred direction. Any of a number of stochastic motion control mechanisms or biasing mechanisms can be used. Some embodiments can resort to conventional steering mechanisms to supplement the stochastic motion control or side force biasing mechanisms.
Patent EA-022508-B1 (EA)
Title: Apparatus for gripping a tubular on a drilling rig
Inventor: ODELL II ALBERT C
IPC: E21B44/00
Filed: 2006-12-12
Abstract: Methods and apparatus for running tubulars into and out of a wellbore. A gripping apparatus is activated with an actuator having a primary actuator and a redundant safety feature. The redundant safety feature may include one or more redundant pistons with fluid operated hydraulic or pneumatic actuators. The gripping apparatus may include an integrated safety system adapted to prevent damage to the tubulars while making and breaking out connections between the tubulars and the tubular string.
Patent EA-021398-B1 (EA)
Title: System and method of capturing geothermal heat from within a drilled well to generate electricity
Inventor: PARRELLA MICHAEL J
IPC: F28D21/00
Filed: 2009-06-15
Abstract: A closed-loop, solid-state system generates electricity from geothermal heat from a well by flow of heat, without needing large quantities of water to conduct heat from the ground. The present invention contemplates uses for depleted oil or gas wells and newly drilled wells to generate electricity in an environmentally-friendly method. Geothermal heat is conducted from the Earth to a heat exchanging element to heat the contents of pipes. The pipes are insulated between the bottom of the well and the surface to minimize heat dissipation as the heated contents of the pipes travel to the surface.
Patent EA-019774-B1 (EA)
Title: Derivatives of 2-pyridin-2-yl-pyrazol-3(2h)-one, preparation and therapeutic use thereof
Inventor: ALTENBURGER JEAN-MICHEL
IPC: A61K31/4162
Filed: 2009-12-24
Abstract: The invention relates to compounds with the formula (I), in a basic state or as an acid addition saltwhere n is equal to 0, 1, 2, 3 or 4; m is equal to 0, 1 or 2; o is equal to 0 or 1; X is a -CH, -CH(R')-, -NH(R')- group or a heteroatom selected from among O and S, where R' is a -(C-C)alkyl, -(C-C)alcoxy, -CH-phenyl, -C(O)Ror -COORgroup, wherein Ris as defined herein; Ris an oxo or -COORgroup, wherein Ris as defined herein; Ris an H atom or a group selected from among the following groups: -(C-C)alkyl, -(C-C)alcoxy, -COOR, -NRR, -C(O)NRR, -SO-NRR, heteroaryl optionally substituted by a -(C-C)alkyl group, -W-phenyl, -W-heteroaryl, -O-W-phenyl and -O-W-heteroaryl, where W, R, R, Rand Rare as defined herein, provided that Rand R, which may be identical or different, (i) independently from one another are an H atom, a -(C-C)alkyl, -(C-C)cycloalkyl, phenyl, heteroaryl, -CH-heteroaryl or -W-OH; or (ii) together with the nitrogen atom that carries them, jointly form a heterocycloalkyl group, optionally substituted by one or more groups selected from among the -(C-C)alkyl and -CH-phenyl groups; W is a -(C-C)alkylene group, optionally substituted by one or more hydroxy groups; Rand R, which may be identical or different, independently from one another are a hydrogen atom or groups selected among the -(C-C)alkyl groups and the -(C-C)cycloalkyl groups, wherein heteroaryl is selected from furanyl, oxadiazolyl and pyridinyl; heterocycloalkyl is selected from 5-, 6- or 7-membered saturated cycle containing a nitrogen atom; and also to the preparation method and to the therapeutic uses of said compounds.
Patent EA-030774-B1 (EA)
Title: Method and system for biometric authentication
Inventor: NACCACHE DAVID
IPC: H04W12/06
Filed: 2011-02-17
Abstract: The application describes a method for biometric authentication of a user to be authenticated from among a plurality of users by means of an authentication system storing a plurality of reference biometric data records, each of which being associated with one of the users, the method comprising providing by the user to be authenticated biometric authentication data using a device connected to a transaction processing terminal for formation of a user's biometric data record; receipt of a subset of reference biometric data records from said set of reference biometric data records among which search for reference biometric data of the user to be authenticated is performed, comparison of said the user's biometric data record formed by the transaction processing terminal to the user's reference biometric data record contained in the received subset of reference users' biometric data records. In accordance with the present invention, a system is also proposed for biometric authentication of a user from among a plurality of users by means of an authentication system, the system containing, in a memory device, a program for implementation of said method, and a machine-readable carrier with a recorded program which, when run, implements said biometric authentication method.
Patent EA-027622-B1 (EA)
Title: Solid state forms of macrocyclic kinase inhibitors
Inventor: MANSFIELD ROBERT K
IPC: A61K31/535
Filed: 2011-02-04
Abstract: Provided herein are salt forms of macrocyclic protein kinase inhibitors, pharmaceutical compositions containing the same, methods of making and using these compounds and compositions to treat proliferative disease mediated by kinase activity.
Patent EA-027590-B1 (EA)
Title: High throughput reactor assembly for polymerization of olefins
Inventor: WEICKERT GUENTER
IPC: B01J19/24
Filed: 2012-03-02
Abstract: Reactor assembly for the production of polymers including a fluidized bed reactor, and a process for the production of polymers in a reactor assembly.
Patent EA-026495-B1 (EA)
Title: Equipment to prepare ore concentrate for pelletizing
Inventor: PALANDER MARKO
IPC: F26B23/02
Filed: 2012-06-13
Abstract: The provided invention relates to an equipment to prepare ore concentrate for pelletizing and sintering/indurating of pellets in ferroalloys production. The equipment comprises a grinder (1) arranged to grind the concentrate to a predetermined grain size. The equipment further comprises a drying apparatus (2, 3, 4) arranged to dry the concentrate before and/or during grinding by the grinder (1).
Patent EA-028083-B1 (EA)
Title: Ciht power system
Inventor: MILLS RANDELL L
IPC: H01M8/22
Filed: 2013-05-21
Abstract: An electrochemical power system is provided that generates an electromotive force (EMF) from the catalytic reaction of hydrogen to lower energy (hydrino) states providing direct conversion of the energy released from the hydrino reaction into electricity, the system comprising at least two components chosen from HO catalyst or a source of HO catalyst; atomic hydrogen or a source of atomic hydrogen; reactants to form the HO catalyst or source of HO catalyst and atomic hydrogen or source of atomic hydrogen; and one or more reactants to initiate the catalysis of atomic hydrogen. The electrochemical power system for forming hydrinos and electricity can further comprise a cathode compartment comprising a cathode, an anode compartment comprising an anode, optionally a salt bridge, reactants that constitute hydrino reactants during cell operation with separate electron flow and ion mass transport, a source of oxygen, and a source of hydrogen. Due to oxidation-reduction cell half reactions, the hydrino-producing reaction mixture is constituted with the migration of electrons through an external circuit and ion mass transport through a separate path such as the electrolyte to complete an electrical circuit. A power source and hydride reactor is further provided that powers a power system comprising (i) a reaction cell for the catalysis of atomic hydrogen to form hydrinos, (ii) a chemical fuel mixture comprising at least two components chosen from: a source of HO catalyst or HO catalyst; a source of atomic hydrogen or atomic hydrogen; reactants to form the source of HO catalyst or HO catalyst and a source of atomic hydrogen or atomic hydrogen; one or more reactants to initiate the catalysis of atomic hydrogen; and a support to enable the catalysis, (iii) thermal systems for reversing an exchange reaction to thermally regenerate the fuel from the reaction products, (iv) a heat sink that accepts the heat from the power-producing reactions, and (v) a power conversion system.
Patent EA-029851-B1 (EA)
Title: Method for producing authigenic rock mineral for altering rock hydrology
Inventor: COATES JOHN D
IPC: C09K8/582
Filed: 2012-10-24
Abstract: The present disclosure relates to methods of reversibly altering the rock hydrology in systems, such as oil reservoirs, by inducing authigenic mineral-precipitating bacteria to produce authigenic rock mineral.
Patent EA-025956-B1 (EA)
Title: Compound powder for applying on the surface of a chewing gum core material
Inventor: DOERR TILLMANN
IPC: A23G4/00
Filed: 2013-03-07
Abstract: The present invention relates to rolling compound powders comprising hydrogenated or non-hydrogenated palatinose for applying to the surface of chewing gum core materials, chewing gum products, processes for reducing the stickiness of compositions of chewing gum core materials by using hydrogenated or non-hydrogenated palatinose-containing rolling compound powders in a chewing gum preparation process as well as the use of hydrogenated or non-hydrogenated palatinose in rolling compound powders for applying to the surface of chewing gum core materials.
Patent EA-039577-B1 (EA)
Title: Connection system of electrical module provided for receiving, processing and transmitting signals
Inventor: WESS ROBERT
IPC: H01R13/645
Filed: 2015-08-26
Abstract: A connection system of an electrical module provided for receiving, processing and transmitting signals includes at least one modular part of a first type (60), at least one modular part of a second type (60'), a mechanical coding appliance, which has coding settings, which allow or prevent a joining together of these modular parts, and a holding appliance (62-64, 62'-64') for holding one modular part on the other modular part when these parts are joined together. Coding elements (10, 10′) are received in a space (51, 51') formed in the modular part of the first or second type (50, 50', 60, 60') and have a projection (31, 31') projecting out of the space. The coding element is disposed so as to be movable to and fro in order to assume two coding positions: a) for joining together of the modular parts a respective projection is disposed offset in the direction of movement with respect to the projection of an opposing coding element, and b) for prevention of joining together of the modular a projection abuts the projection of an opposing coding element.
Patent EA-025666-B1 (EA)
Title: Powder composition for disinfection of the teats of dairy animals
Inventor: GELMI FABIO
IPC: A61K31/18
Filed: 2013-11-06
Abstract: The present invention relates to a powder composition comprising sorbitol, chloramine-T and natural gum, wherein the sorbitol and chloramine-T are in a weight ratio of at least 3:1, for the post-milking teat disinfection of dairy animals. In particular, said composition is effective as bactericidal agent, while without causing irritation or reddening of the skin. Also provided is a non-medical use of said composition as a bactericidal agent in the treatment of surfaces or supports.
Patent EA-029296-B1 (EA)
Title: Pyridine derivatives as rearranged during transfection (ret) kinase inhibitors
Inventor: EIDAM HILARY SCHENCK
IPC: C07D413/12
Filed: 2014-03-14
Abstract: The present invention relates to novel compounds of formula (I), wherein the meanings of radical are defined in the claims, and to pharmaceutical compositions containing them. The provided compounds are inhibitors of the Rearranged during Transfection (RET) kinase and can be used in therapy.
Patent EA-035329-B1 (EA)
Title: Method and composition for the treatment of asthma or allergic rhinitis or chronic obstructive pulmonary disease
Inventor: DALVI MUKUL
IPC: A61K31/137
Filed: 2014-10-06
Abstract: The present invention relates to a method for the treatment of asthma or allergic rhinitis or chronic obstructive pulmonary disease (COPD) comprising administering to a patient a dry powder medicament comprising fluticasone propionate, salmeterol xinafoate and a lactose carrier; wherein said medicament of delivered via an inhaler, wherein the delivered dose of salmeterol per actuation is less than 50 g; wherein the particle size of salmeterol xinafoate is d10=0.4-1.3 m, d50=1.4-3.0 m, d90=2.4-6.5 m, and at least 95% of salmeterol xinafoate particles has the particle size less than 10 m, measured by laser diffraction in an aqueous dispersion. Furthermore, the present invention relates to a composition for the treatment of asthma or allergic rhinitis or chronic obstructive pulmonary disease (COPD) for use in a dry powder inhaler; wherein said composition comprises fluticasone propionate, salmeterol xinafoate and a lactose carrier; wherein the particle size of salmeterol xinafoate is d10=0.4-1.3 m, d50=1.4-3.0 m, d90=2.4-6.5 m, and at least 95% of salmeterol xinafoate particles has the particle size less than 10 m.