baber/WOPTO huggingface dataset:
Patent NZ-594129-A (NZ)
Title: Dosing device for generating a gas flow with an active substance finely dispersed in the latter
Inventor: KAMLAG YORICK
IPC: A61M15/00
Filed: 2009-12-10
Abstract: 594129 Dosing device for generating a gas flow with an active substance finely dispersed in the latter. (2) The invention relates to a dosing device for generating a gas flow with an active substance (2) finely dispersed in the latter, as a result of an under-pressure applied to a mouthpiece (6) of the dosing device, with a first gas flow channel (60, 61, 62, 63, 68), and with a dosing chamber (14) that can be fitted in the area of the first gas flow channel, and with a dosing chamber release mechanism which has a separating element (54, 76, 77) that can be moved between a closed position and an open position, wherein the first gas flow channel and/or a connection between the first gas flow channel and the dosing chamber is blocked when the separating element is in the closed position, and the first gas flow channel and/or the connection between the first gas flow channel and the dosing chamber is freed when the separating element is in the open position, and with a slide guide element (53, 55) on which the separating element (54, 76, 77) is movable between the closed position and the open position and can be driven by the under-pressure applied to the mouthpiece, and wherein the separating element and/or the slide guide element is provided at least in a sliding contact area with a slide element (100a, 100b, 101) that influences the sliding friction properties between the separating element and the slide guide element. This design of the separating element and/or of the slide guide element ensures that the separating element is reliably triggered after a suction stream is generated, such that the function of the dosing device can be more precisely reproduced and is more reliable.
Patent NZ-596453-A (NZ)
Title: Antibiotic-free plasmid
Inventor: AUDONNET JEAN-CHRISTOPHE
IPC: C12N15/63
Filed: 2010-05-24
Abstract: 596453 Disclosed is a drugless (antibiotic-free plasmid) plasmid comprising a polynucleotide encoding a cI repressor protein. Further disclosed is a method of producing a drugless plasmid comprising the steps of: 1) engineering a gram negative bacterium host strain comprising a heterologous polynucleotide inserted by allelic replacement in one or more non-essential region of the host chromosome; 2) constructing a DNA plasmid comprising a polynucleotide encoding a cI repressor protein; 3) transforming the bacterium host strain with the DNA plasmid comprising the gene encoding the cI repressor protein; 4) growing the transformed bacterium host stain in the presence of sucrose at a temperature ranging from 30oC to 42oC; and 5) recovering the DNA plasmid.
Patent NZ-598213-A (NZ)
Title: Sigma ligands for the prevention or treatment of pain induced by chemotherapy
Inventor: BAEYENS-CABRERA JOSE MANUEL
IPC: A61K33/243
Filed: 2010-08-12
Abstract: Disclosed herein is the use of a sigma ligand of formula (I) to prevent or treat pain induced by a chemotherapeutic agent, especially pain induced by taxanes, vinca alkaloids or platinum-containing chemotherapeutic drugs. In one embodiment the sigma ligand is 4-{ 2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl} morpholine.
Patent NZ-598275-A (NZ)
Title: Methods for improving recombinant protein expression
Inventor: CLARKE HOWARD ROBERT GRAHAME
IPC: C07H21/04
Filed: 2010-08-06
Abstract: Disclosed is a method for increasing heterologous protein expression in a host cell comprising the step of culturing the host cell under conditions that allow for heterologous protein expression, said host cell comprising a first heterologous polynucleotide sequence encoding said heterologous protein, said host cell further comprising a second polynucleotide sequence having a protein coding sequence for a selectable marker protein, said second polynucleotide having a sequence modification compared to a wild-type polynucleotide encoding said selectable marker protein, said sequence modification reducing translation efficiency of mRNA encoded by said second polynucleotide, said second polynucleotide having said sequence modification and said wild-type polynucleotide encoding identical amino acid sequences for said selectable marker protein, said first polynucleotide and said second polynucleotide encoded on a single Chinese hamster elongation factor 1 (CHEF1) expression vector under transcriptional control of distinct promoters, wherein said host cell is not present in a human. Particularly disclosed is a method as described above wherein the selectable marker is dihydrofolate reductase (dhfr).
Patent NZ-598925-A (NZ)
Title: Method and apparatus for measuring and presenting eating rate
Inventor: ZANDIAN MOTJABA
IPC: G06F19/00
Filed: 2010-09-28
Abstract: 598925 Disclosed is a medical apparatus made up of at least two devices adapted to measure eating rate (12). The apparatus is used to teach people to eat according to a predetermined graphic eating curve (10) displayed on a screen. The apparatus includes a first device with a screen storing the predetermined graphic eating curve (10) in a memory. The first device also has at least one of remote near field radiation and wire capabilities for communication with a related second device. The related second device is a scale adapted to communicate with said first device. The second device also has at least one of remote near field radiation and wire communication capabilities adapted to said first device. The apparatus also includes means in stored in the memory for automatically calculating equations for predetermined eating curves (10) based on data obtained from a cumulative food intake in a control meal through an introductory curve followed by training curves. The cumulative food intake is fitted to a quadratic equation y=ax2+bx+c, where the parameter “y” represents food intake, “a” represents a change in the slope of the curve over time x minutes, “b” represents a constant slope of the curve over time - the initial rate of eating - and “c” represents food intake at the start of a meal. The introductory curve has the same properties as the cumulative food intake obtained in the control meal.
Patent NZ-600136-A (NZ)
Title: Pyrazine derivatives and their use in the treatment of neurological disorders
Inventor: VEENSTRA SIEM JACOB
IPC: A61K31/4965
Filed: 2010-12-22
Abstract: 600136 Disclosed herein is a compound of formula (I), wherein the variables are defined in the specification, a pharmaceutical composition comprising said compound, a combination comprising said compound and a second drug substance, and the use of said compound in the treatment of Alzheimer's disease or mild cognitive impairment. Embodiments of the compound include the following: 5-bromo-pyridine-2-carboxylic acid [3-(6-amino-2,4-dimethyl-3-oxo-2,3,4,5-tetrahydro pyrazin-2-yl)-4-fluoro-phenyl]-amide, 3,5-dichloro-pyridine-2-carboxylic acid { 3-[6-amino-4-(2-methoxy-ethyl)-2-methyl-5-oxo-2,3,4,5-tetrahydro-pyrazin-2-yl]-4-fluoro-phenyl} -amide, and 5-amino-3-{ 5-[(5-cyano-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl} -3-difluoro methyl-3,6-dihydro-2H-pyrazine-1-carboxylic acid methyl ester.
Patent NZ-602093-A (NZ)
Title: Inner nozzle for transferring molten metal contained in a vessel, system for clamping said nozzle and casting device
Inventor: BOISDEQUIN VINCENT
IPC: B22D41/34
Filed: 2011-03-17
Abstract: 602093 The disclosure relates to an inner nozzle (12) to be mounted onto a tube exchange device for holding and replacing an exchangeable pouring nozzle for casting molten metal out of a vessel, said tube exchange device comprising a frame with a casting opening, said frame being suitable for being fixed to the lower side of a metal casting vessel and comprising a first, upper portion and a second, lower portion, joining at a middle section plane defining the plane where an inner nozzle (12) and an exchangeable pouring nozzle form a sliding contact, - the upper side portion of the frame comprising means for receiving and clamping (50a) in place at its pouring position a bearing surface of an inner nozzle (12) against a support portion of the upper side portion of the frame, such that the through bore of the inner nozzle (12) is in fluid communication with the casting opening, and - the lower portion comprising means for loading and moving along a first direction (X) into casting position an exchangeable pouring nozzle characterised in that at least two of the clamping means (50a) are arranged transverse to said first direction (X).
Patent NZ-603998-A (NZ)
Title: Methods for manufacturing tetranor-prostaglandin d, j, e, a and f metabolites
Inventor: ENDRES GREGORY W
IPC: C07C51/347
Filed: 2011-06-14
Abstract: Patent No. 603998 Disclosed is a method for preparing tetranor-prostaglandin D (compound 14), J (compound 15), E (compound 27A/B), A (compound 28A/B) and F (compound 34).
Patent NZ-606488-A (NZ)
Title: Process for separation of gases
Inventor: UNGERANK MARKUS
IPC: C10L3/10
Filed: 2011-05-26
Abstract: 606488 An apparatus for separating crude gas mixtures (17) into two fractions each of increased purity. The apparatus has a feed stream membrane separation stage (1) to separate a feed stream (5) comprising at least two components into a first permeate stream (6) and a first retentate stream (7); a retentate membrane separation stage (2) to divide the first retentate stream (7) into a second permeate stream (9) which is supplied to the feed stream (5) and a second retentate stream (8) which is withdrawn as a first product; a permeate membrane separation stage (3) to divide the first permeate stream (6) into a third retentate stream (10) which is supplied to the feed stream (5) and a third permeate stream (11) which is withdrawn as a second product; and at least one compressor (4) and/or at least one vacuum pump. The first permeate stream (6) is not subjected to any recompression. At least the feed stream membrane separation stage (1) employs gas separation membrane modules having a mixed gas selectivity of at least 30. The apparatus is configured such that the gas volume recycled in the second permeate stream (9) and in the third retentate stream (10) totals less than 60% by volume of the volume of the crude gas stream (17), and the concentration of at least one permeate gas of the feed stream membrane separation stage (1), after recycling of the second permeate stream (9) and of the third retentate stream (10), is increased by at least 2% in the feed stream (5) compared to the concentration in the crude gas stream (17).
Patent NZ-616433-A (NZ)
Title: Bcma (cd269/tnfrsf17) -binding proteins
Inventor: ALGATE PAUL
IPC: C07K16/28
Filed: 2012-05-24
Abstract: Discloses antigen binding proteins and fragments thereof which specifically bind B Cell Maturation Antigen (BCMA), particularly human BCMA (hBCMA) and which inhibit the binding of BAFF and APRIL to the BCMA receptor, and wherein the antigen binding protein comprises CDRs of SEQ ID NOs: 1-6 or variants thereof, wherein the sequences are as defined in the complete specification. Further disclosed are pharmaceutical compositions, screening and medical treatment methods.
Patent NZ-620828-A (NZ)
Title: Sodium ibuprofen tablets and methods of manufacturing pharmaceutical compositions including sodium ibuprofen
Inventor: TAYLOR ANGELA P
IPC: A61K9/20
Filed: 2010-06-21
Abstract: Provided are sodium ibuprofen compositions and methods of manufacturing tablets and caplets comprising sodium ibuprofen. The compositions are advantageous because they allow for the formation of tablets having low sodium content and further provide tablets exhibiting improved physical stability, high tablet hardness and high strength, coupled with excellent dissolution and bioavailability characteristics. The compositions and processes are further advantageous because tablets can be produced in large quantities without an unacceptable number of defective tablets. In one embodiment the composition comprises a core comprising sodium ibuprofen dihydrate.
Patent NZ-623209-A (NZ)
Title: Pyrrolobenzodiazepines and conjugates thereof
Inventor: FLYGARE JOHN A
IPC: C07D519/00
Filed: 2012-10-12
Abstract: A conjugate of formula (A): the dotted lines indicate the optional presence of a double bond between C1 and C2 or C2 and C3; R2 is independently selected from H, OH, =0, =CH2, CN, R, OR, =CH-RD, =C(RD)2, 0-S02-R, C02R and COR, and optionally further selected from halo or dihalo; where RD is independently selected from R, C02R, COR, CHO, C02H, and halo; R6 and R9 are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR’, NO2, Me3Sn and halo; R7is independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR’, N02, Me3Sn and halo; Y is selected from a single bond, and a group of formulae A1 or A2: where N shows where the group binds to the N10 of the PBD moiety; RL1 and RL2 are independently se!ected from H and methyl, or together with the carbon atom to which they are bound form a cyclopropylene group; CBA represents a cell binding agent; Q is independently selected from O, S and NH; R11 is either H, or R or, where Q is O, S03M, where M is a metal cation; R and R’ are each independently selected from optionally substituted C1-12alkyl, C3-20 heterocyclyl and C5-20aryl groups, and optionally in relation to the group NRR’, R and R’ together with the nitrogen atom to which they are attached form an optionally substituted 4-, 5-; 6- or Z-metfibered heteracyciie ring; wherein R12 R16, R19 and R17 are as defined for R2, R6, R9 and R7 respectively: wherein R” is a Calky!ene group, which chain may be interrupted by one or more heteroatoms, e.g. O, S, N(H} ; NMe and/or aromatic rings, e.g. benzene or pyridine, which rings are optional y substituted; X and X’ are independently selected from O, S and N(H).
Patent NZ-626144-A (NZ)
Title: Oral care compositions
Inventor: VAZQUEZ JOE
IPC: A61Q11/00
Filed: 2011-12-21
Abstract: Provided are aqueous oral compositions comprising a cationic steroidal compound/ceragenin and a quaternary ammonium compound. A preferred cationic steroidal compound/ceragenin is a compound of general formula (I). A preferred quaternary ammonium compound is cetylpyridinium chloride. Further provided is the use of cationic steroidal compounds/ceragenins to treat ginigivitis, periodontitis, dental caries and oral malodour.
Patent NZ-626645-A (NZ)
Title: Knotless suture, and kit containing same
Inventor: KIM YOUNG JAE
IPC: D02J3/00
Filed: 2012-12-24
Abstract: The present invention relates to a suture which is firmly maintained and fixed to an operational site to stably sustain suturing or lifting effects for a long time. More specifically, the present invention provides a suture having a conic or pyramidal shape with a cut top, wherein a suture support comprising a communication hole penetrating the both ends is provided at one end. The suture support can have one or more portions which are cut vertically from a lower end at a lower end portion having a larger diameter between the both ends, or a part of a lower end can be removed so as to form one or more gaps formed from the end at a wall of the end portion.
Patent NZ-628329-A (NZ)
Title: Formulations of (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
Inventor: MENON ANIL
IPC: A61K31/4035
Filed: 2014-06-16
Abstract: Pharmaceutical compositions and single unit dosage forms of apremilast, i.e., (+)-2-[1-(3- ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline- 1,3-dione, or a pharmaceutically acceptable stereoisomer, prodrug, salt, solvate, hydrate, or clathrate, are provided herein. Also provided are methods of treating, managing, or preventing various disorders, such as diseases or disorders ameliorated by the inhibition of TNF-a production in mammals. Examples of the diseases include: a viral, genetic, inflammatory, allergic or autoimmune disease.
Patent NZ-628392-A (NZ)
Title: Use of a pyrazole derivative in the treatment of acute exacerbations of chronic obstructive pulmonary disease
Inventor: FORD PAUL ANDREW
IPC: C07D231/38
Filed: 2013-03-19
Abstract: Disclosed is the use of a pharmaceutical composition that contains 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide (acumapimod) or a pharmaceutically acceptable salt, hydrate or solvate thereof in the manufacture of a medicament for the treatment of acute exacerbations of chronic obstructive pulmonary disease, wherein the pharmaceutical composition is adapted for oral administration, preferably in the form of a tablet. Acumapimod is also known as BCT-197, BCT197A2201 having CAS#: 836683-15-9).
Patent NZ-631396-A (NZ)
Title: Improvements in and relating to fertiliser and like compositions and the manufacture thereof
Inventor: MURRAY SELWIN ZANDER
IPC: C05G3/60
Filed: 2014-09-12
Abstract: Disclosed are ethoxylated primary alcohols (linear alcohol ethoxylates) and unrefined plant oils for a coating compositions. In particular a fertilizer composition with trace elements being applied to a fertilizer chip or granule with the coating compositions. Examples of the vegetable oil includes sunflower oil, palm oil, soy bean oil, canola oil, olive oil, sesame seed oil or peanut oil.
Patent NZ-709420-A (NZ)
Title: Methods of treatment of fibrosis and cancers
Inventor: HANF RÉMY
IPC: A61P43/00
Filed: 2014-01-20
Abstract: The present invention relates to the use of compound 1-[4-methylthiophenyl]-3-[3,5- dimethyl-4-carboxydimethylmethyloxyphenyl]prop-2-en-1-one for treating fibrotic diseases and cancers.
Patent NZ-710815-A (NZ)
Title: Clip for perimeter trim
Inventor: GULBRANDSEN PEDER J
IPC: E04B9/30
Filed: 2014-01-23
Abstract: A single piece sheet metal clip including a trim engaging part and a mounting part extending or extendable from the trim engaging part at a right angle, the trim engaging part having a limited height when the clip is tilted from a vertical portion and a height greater than the limited height when upright whereby the trim engaging part may be inserted between opposed channels on a rear side of a trim strip and upper and lower edges are trapped in a respective channel when rotated from the tilted position to an upright position, the trim engaging part having an integral element separated by a slot resiliently deflected in a channel when the clip is turned upright, said resilient element having a sharp corner releasably locking the clip against a reversal of said movement and thereby maintaining the trim engaging part trapped in said channels.
Patent NZ-712453-A (NZ)
Title: Tricyclic heterocycles as bet protein inhibitors
Inventor: RODGERS JAMES D
IPC: A61K31/542
Filed: 2014-03-14
Abstract: The present invention relates to tricyclic heterocycles of Formula (I) or pharmaceutically acceptable salts thereof, which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer, viral infections, autoimmune diseases and inflammatory diseases.
Patent NZ-718174-A (NZ)
Title: Methods and compositions for regulation of transgene expression
Inventor: REBAR EDWARD J
IPC: C12N15/85
Filed: 2012-09-21
Abstract: Directed toward an isolated cell which comprises a non-naturally occurring nuclease that cleaves an endogenous albumin gene, and a transgene that encodes Factor VIII, Factor IX, Factor XI and/or alpha-I antitrypsin. Also provides methods of expressing said transgenes and the use of the isolated cell in the manufacture of a medicament for the treatment of haemophilia/COPD/liver disorders
Patent NZ-727799-A (NZ)
Title: Ultra reliable link design
Inventor: BHUSHAN NAGA
IPC: H04W24/10
Filed: 2015-07-15
Abstract: Techniques are described for wireless communication. A first method includes measuring, by a first device, a condition of a wireless channel; and generating at least one channel side information feedback message based on the measured condition of the wireless channel. The at least one channel side information feedback message provides information on a relationship of a set of parameters, including a data rate parameter, an error probability parameter, and at least one of a deadline parameter or a transmission link parameter. A second method includes measuring, by a first device, interference on a wireless channel; identifying an interfering device for the wireless channel based on the measurement; and generating a channel side information feedback message based on the measured interference on the wireless channel. The channel side information feedback message indicates the interfering device for the wireless channel and a correlation of interference from the interfering device with time or frequency.
Patent NZ-733952-A (NZ)
Title: Acid composition based on leonardite and amino acids
Inventor: VALIERI GIANLUCA
IPC: C05G3/70
Filed: 2016-02-04
Abstract: The invention refers to an acid composition containing micronized leonardite as a dispersion, amino acids and surfactants for use as fertiliser, plant activator and/or nutrient and to a procedure for obtaining this composition. The provision of the composition with leonardite as a micronised dispersion allows for a more stable formulation which can be effectively used with amino acids and other phytosanitary adjuvants.
Patent NZ-737666-A (NZ)
Title: Antibody binding to fcrn for treating autoimmune diseases
Inventor: KIM SUNG WUK
IPC: C12N15/13
Filed: 2015-04-30
Abstract: The present disclosure relates to an isolated anti-FcRn antibody, which is an antibody binding to FcRn (stands for neonatal Fe receptor, also called FcRP, FcRB or Brambell receptor) that is a receptor with a high affinity for IgG or a fragment thereof, a method of preparing thereof, a composition for treating autoimmune disease, which comprises the antibody, and a method of treating and diagnosing autoimmune diseases using the antibody. The FcRn-specific antibody according to the present disclosure binds to FcRn non-competitively with IgG to reduce serum pathogenic auto-antibody levels, and thus can be used for the treatment of autoimmune diseases.
Patent NZ-747881-A (NZ)
Title: Automobile high-temperature pest extermination device
Inventor: DAMON SCOTT JACKSON
IPC: A01M19/00
Filed: 2018-10-31
Abstract: To provide an automobile high-temperature pest extermination device which can efficiently exterminate pests by a high-temperature treatment without the use of a fumigation agent. A device for applying, for a predetermined interval, heated air which is heated to a pest extermination temperature to a to-be-treated automobile C which is housed in a freely accessible manner in a treatment chamber 20 to exterminate pests inside the automobile includes a circulation fan device 30 arranged in the treatment chamber, a suction part 32 of which is oriented toward the inside of the treatment chamber, a heating member 40 mounted in a discharge part 33 of the circulation fan device, and a rectification member 45 for adjusting the flow direction of the heated air delivered into the chamber via the heating member.