Patent SG-11201807985X-A (SG)
Title: Compositions and methods for increasing iron intake in a mammal
Inventor: GILMER JOHN
IPC: A61K47/02
Filed: 2017-03-15
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/158030 Al 21 September 2017 (21.09.2017) WIPO I PCT 111111111111110111011111111111010111110 0111111111110111110111110111111111110111111 (51) International Patent Classification: A61K 9/16 (2006.01) A61K 47/42 (2017.01) A61K 47/02 (2006.01) A61K 33/26 (2006.01) A61K 9/06 (2006.01) (21) International Application Number: PCT/EP2017/056134 (22) International Filing Date: 15 March 2017 (15.03.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16160539.9 15 March 2016 (15.03.2016) EP (71) Applicant: SOLVOTRIN THERAPEUTICS LTD [IE/IE]; Inchera Little Island, Cork, Co Cork (IE). (72) Inventors: GILMER, John; Redgap, Rathcoole, Co Dub- lin (IE). GABOR, Radics; 18 Coldricks Pass, Dunshaugh- lin, Co Meath (IE). WHELEHAN, Michael; 46 St. Mobhi Road Newtown, Rathangan, Co Meath (IE). WANG, Jun; 6 Claremont Avenue Honey Park, Dun Laoghaire, Co Dub- lin (IE). O'FLYNN, Pat; Redoaks Maryborough Orchard, Douglas, Co Cork (IE). LEDWIDGE, Pat; 14 Marybor- ough Orchard, Douglas, Co Cork (IE). = (74) Agent: TOMKINS & CO; 5 Dartmouth Road, Dublin, 6 ( 1 E). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) W O 20 17 / 15 8030 Al (54) Title: COMPOSITIONS AND METHODS FOR INCREASING IRON INTAKE IN A MAMMAL Figure 5. pH profile of compositions of the invention in simulated gastric and intestinal fluid (ST1501, Ferrous Sulfate) d Final pH inpH 1.6 Simulated Gastric Solution 6 i d Final pH in pH 6.6 Simulated Intestinal Solution T 5T1501 (25mg Iron equivalent) Ferrous Sulfate (25 mg Iron Equivalent) (57) : Compositions containing iron, buffering agent and denatured protein have been prepared that are capable of increas- ing serum iron in a subject. For example, spray dried microbeads have been prepared containing iron entrapped within a protein mat - rix and unbound iron in a buffered composition that provides a gastroprotective effect, preserves iron in the more available Fe form and improves iron bioavailability in humans relative to previously known vehicles for delivering iron to a subject.