baber/WOPTO huggingface dataset:
Patent SG-11201909649S-A (SG)
Title: P-ethoxy nucleic acids for bcl2 inhibition
Inventor: ASHIZAWA ANA
IPC: A61K31/7125
Filed: 2018-04-19
Abstract: G-- base 3x —0— 18 base_lx 18 base 3x 7 base 1x EMPTY 3x 40 80 LIPOSOMAL BO ANT SENSE (rwirnL) (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 October 2018 (25.10.2018) WIP0 I PCT IiiimmomiolollmonolomomulioliolionovoimIE (10) International Publication Number WO 2018/195253 Al (51) International Patent Classification: A61K 9/127 (2006.01) A61K 47/69 A61K 31/7125 (2006.01) A61P 35/00 A61K 47/54 (2017.01) C07H 21/02 (2017.01) (2006.01) (2006.01) (21) International Application Number: PCT/US2018/028267 (22) International Filing Date: 19 April 2018 (19.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/487,302 19 April 2017 (19.04.2017) US (71) Applicant: BIO-PATH HOLDINGS, INC. [US/US]; 4710 Bellaire Blvd., Suite 210, Bellaire, TX 77401 (US). (72) Inventors: ASHIZAWA, Ana, Tani; C/o Bio-path Hold- ings, Inc., 4710 Bellaire Blvd., Suite 210, Bellaire, TX 77401 (US). NIELSEN, Peter; C/o Bio-path Holdings, Inc., 4710 Blvd., Suite 210, Bellaire, TX 77401 (US). (74) Agent: SCHNEPP, Amanda, S.j.; Parker Highlander Pllc, 1120 S. Capital Of Texas Highway, Bldg. One, Suite 200, Austin, TX 78746 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: P-ETHOXY NUCLEIC ACIDS FOR BCL2 INHIBITION FIG. 1 1-1 (57) : Provided herein are improved delivery systems for oligonucleotides, said delivery system comprising a liposome that © comprises neutral phospholipids and a P-ethoxy oligonucleotide, which targets a BCL2-encoding polynucleotide. Methods of treating ei patients with said delivery systems are also provided. [Continued on next page] C WO 2018/195253 Al MIDEDIMOMMIDEFIEDMOMMEIHEINDEVOIS Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))
Patent IS-1854-B (IS)
Inventor: LINDBERG PER LENNART
IPC: A61K31/44
Filed: 1994-05-06
Abstract: The use of an alkaline salt of the (-)-enantiomer of omeprazole for the manufacture of a pharmaceutical preparation having improved pharmacokinetic and metabolic properties, such as improved therapeutic profile when treating gastric acid related diseases.
Patent AT-409196-B (AT)
Title: Optical display device (visual display unit)
Inventor: FEGER DIETER MAG
IPC: G02B23/14
Filed: 1999-03-22
Granted: 2002-06-25
Abstract: An optical display device 1, especially for a weapon, has a lens 2 and an optical system for viewing the image of objects located in the field of view (visual field) of the lens 2. The optical system for viewing the image comprises two mutually separated partial optical systems 3, 4 which are to be aligned at least approximately with one another in the direction of the optical axis. The first partial optical system 3, which is mechanically coupled to the lens 2, is fixed remote from the viewer, preferably on the weapon. The second partial optical system 4 is provided separated mechanically and spatially from the first partial optical system 3 in front of at least one eye 6 of the viewer. The first partial optical system 3 has a large exit back focus (intercept distance) and a large exit pupil which is adapted to the field of view of the second partial optical system 4. <IMAGE>
Patent AT-393423-B (AT)
Inventor: BRINKMANN JUERGEN DR
IPC: H01M50/172
Filed: 1990-03-13
Granted: 1991-10-25
Abstract: In the feed-through disclosed, an annular sleeve (3) made of plastic material is attached to the shaft (1) of the terminal at the same height as the cell cover (6). The sleeve extends through the cover and is joined to it to form a seal between the two. The internal diameter of the sleeve is a defined amount larger than the external diameter of the terminal shaft which, in the vicinity of the sleeve, has at least two rectangular cross-section annular grooves (4) located a certain axial distance apart. Located in each groove is an O-ring (5) made of elastomeric material, the difference between the internal diameter of the sleeve and the radial depth and axial width of the grooves being chosen so that the O-rings are deformed from a circular cross-section to a cross-section with a shorter and a longer axis, thus pressing the O-rings against the grooves and the sleeves in four areas where the ring is flattened.
Patent AT-396889-B (AT)
IPC: F04B53/16
Filed: 1991-03-21
Granted: 1993-12-27
Abstract: The invention relates to a sealing device for movable parts of high pressure arrangements, having a ring (6) which is placed on the pressure-space side in the opening (2) to be sealed off, can be subjected to forces, essentially radial to the axis (22) of the movable part (4), of the compressed medium and is penetrated by the movable component (4), that end of the ring (6) which is remote from the pressure space having a circumferential recess (7) which faces the movable part (4) and accommodates a circumferential end projection (19) of a sleeve (5), which projection is matched to the recess (7), preferably with surface contact, faces the movable part (4) and is situated on the pressure-space side, the ring (6) being pressed against the sleeve (5) by the pressure prevailing in the pressure space and, for the purpose of sealing off the pressure space, pressing the end projection (19) against the movable part (4).   According to the invention, that (those) surface(s) (17, 17', 17'', 17''') of the end projection (19) of the sleeve (5) which rests rest against the surface (40) of the recess (7) of the ring (6) deviates (deviate) in shape from a straight line in a section through the axis (22) of the movable component (4), from its end point (18) resting against the movable component (4) and situated on the pressure-space side to its end resting against the inner surface (20) of the opening (2), and comprises (comprise) at least one straight region and/or at least one curved region. <IMAGE>
Patent AT-406481-B (AT)
Title: Liq. pig iron@ or steel prodn. with increased productivity - by producing sponge iron in redn. zone, feeding into melting zone with carbon@ and oxygen@-contg. gas, recycling obtd. redn. gas contg. hydrogen@ and carbon mon:oxide, etc.
Inventor: DIEHL JOERG DIPL ING
IPC: C21B13/14
Filed: 1995-04-25
Granted: 2000-05-25
Abstract: Liq. pig iron or steel is produced by adding iron ore in pieces or pellets together with additive into a redn. zone (12) where sponge iron is produced which is then fed into melting zone (8) with carbon and O2-contg. gas. A CO-contg. and H2-contg. redn. gas is produced and passed back to the redn. zone (12) where it is converted to an export gas which is drawn off and subjected to a CO2 eliminating process before being passed to a further redn. zone (21) for direct redn. of more iron ore. A part of the redn. gas produced in the zone (8) is drawn off and fed directly to the zone (21), by-passing the CO2 elimination stage. The plant for carrying out this process is also claimed.
Patent HU-183061-B (HU)
Title: Process for preparing penam-3-carboxylic acid derivatives with antibacterial activity and pharmaceutical compositions containing such compounds
Inventor: BENTLEY PETER H
IPC: C07D499/46
Filed: 1980-02-29
Abstract: A penicillin of formula (I) or a pharmaceutically acceptable salt-or in vivo hydrolysable ester thereof:
     wherein R is C 1-6  alkyl; an optionally substituted 5-membered. heterocyclic ring containing one or two heteroatoms selected from oxygen, sulphur and nitrogen; phenyl; mono-substituted phenyl where the substituent is halogen, hydroxy, C 1-6  alkoxy, nitro amino, C 1-6  alkyl, or C 1-6  haloalkyl, C 1-6  alkylcarbonyloxy, or C 1-6  alkyl sulphonylamino; or di-substituted phenyl where the substituents are selected from hydroxy, halogen, methoxy, acetoxy and amino; and X represents a group of formula:
           wherein R 1  represents C 1  to C 6  alkyl, or C 1  to C 6  alkoxy. Their preparation and use is described.
Patent HU-183350-B (HU)
Inventor: PEREDI JANOS
IPC: G06F3/02
Filed: 1981-03-05
Abstract: A találmány tárgya kapcsolási elrendezés analóg vagy digitális jelek kalkulátorba történő betáplálására, amely alkalmassá teszi a kalkulátort műszeres vizsgálatok, kísérletek vagy mérési eredmények „on-line” feldolgozására. A találmány szerinti kapcsolási elrendezés analóg-digitál konverter, tároló és ütem jelgenerátor segítésével vezérli a kódkonverteren keresztül a számmátrix kapcsoló egységet, melynek kimenetei a kalkulátor klaviatúra sor és oszlop kivezetéseire csatlakoznak. Programozható memória egység beiktatásával program mátrix kapcsoló egységen keresztül lehetséges a kalkulátor klaviatúra sor és oszlop kivezetéseinek vezérlése. ik  lábra -1-
Patent HU-187218-B (HU)
Title: Wire relieving device for electric apparatuses
Inventor: ANGYAL ISTVAN
IPC: H01R13/58
Filed: 1983-02-17
Abstract: The invention relates to a stress-relief structure for the lead of electrical apparatuses, preferably of installed connections, supporting elements being arranged in the apparatus housing on two sides of the lead. The supporting element which is arranged on the one side has at least one point whose distance from the straight line, which is defined by two points which are arranged in opposite directions along the lead on supporting elements which are fitted on the opposite side, is smaller than the diameter d of the lead.
Patent HU-191249-B (HU)
Title: Process for preparing new pyrazolo /1,5-a/pyridine derivatives
Inventor: IRIKURA TSUTOMU
IPC: C07D471/04
Filed: 1984-02-27
Abstract: The present invention is concerned with certain novel pyrazolo[7,5-a]pyridine derivatives, which are prepared by various means. The compounds of the present invention are antiallergic agents, referred to SRS-A antigonists, and useful for treatment of allergic diseases.
Patent IT-1235847-B (IT)
Title: Procedure for the realization of soles in leather, equipped with spines or anti-slide plates in relief, attained by stamping together with one arch support positioned on the internal face of the sole
Inventor: SGARIGLIA ANGELO
IPC: A43D/
Filed: 1989-10-27
Granted: 1992-11-06
Abstract: The present document for industrial invention has as its object a procedure for the realization of soles in leather, equipped with a tread in segmented relief, attained by stamping of thermoplastic resin or P.V.C., making a single body with an arch support formed on the upper face of the sole, which is oriented toward the sole of the foot. The procedure mentioned consists of making a series of clustered holes in a sheet of leather, for every protuberance to be realized on the flat of the sole, which must be separate from one another a distance equal or less than the thickness of the sheet of leather.
Patent LT-4244-B (LT)
Title: Hematological dyestuff and method for preparing thereof
Inventor: JURAS VIDAS
IPC: G01N33/48
Filed: 1996-03-20
Abstract: This invention is a mixture of paint, which can be used in microbiological and haematological research, for medical diagnostics. This mixture of haematological paint consists of methylene blue, azure 1 and eosin ratio 1: (0.03-0.05):1 and their solvent, consisting of the mixture of N, N- dimethylformamide and distilled water, ratio 1:9. The paint production method is also presented in the invention. The advantages of this paint production method are the following: concentrated paint does not form precipitates; remains stable for a long time; shortens the duration of the coloration process; micro-organisms and neutrophil granules and nucleuses are painted in different colours; precipitates do not form in the painted swabs.
Patent LT-3409-B (LT)
Title: Cell for an apparatus of preferably communication facilities
Inventor: PRADOS RAFAEL RODRIGUEZ
IPC: H05K7/14
Filed: 1993-08-05
Abstract: An edge mask for a printed circuit board comprises a T-sectioned strip 1, to the base web of which can be secured a printed circuit board, via lugs and screws. The strip 1 carries a handle 3 at each end pivoted on a respective shaft 13 having side walls which pass through a slot 8 and cut-away 7 and end in hooks 14 which engage a subframe member 11 of apparatus in which the board is assembled. The handles can occupy alternative retaining and pulling out positions, and are biased by respective springs 15 into the retaining position. Contact strips 10 are also provided for effecting an earth connection to the apparatus frame.
Patent NO-134872-B (NO)
Inventor: HEDSTROEM D I
IPC: B27G11/00
Filed: 1973-02-22
Abstract: Fremgangsmåte for sammenføyning av trematerialer ved hjelp av herdbare lim.
Patent RS-49596-B (RS)
Inventor: BOHN MANFRED
IPC: A61K31/44
Filed: 1997-09-16
Abstract: Primena farmaceutske kompozicije koja sadrži hidrofilno sredstvo za formiranje gela, vodu, agense za kvašenje i širenje i jedinejnje prema formuli I ili fiziološki prihvatljivu so jedinjenja prema formuli I, pri čemu su R1, R2 i R3 isti ili različiti, predstavljaju atom vodonika ili alkil grupu sa 1 do 4 atoma ugljenika, i R4 predstavlja zasićen ugljovodonik sa 6 do 9 atoma ugljenika, za dobijanje leka u obliku gela za lečenje i profilaksu mikoza kože. Prijava sadrži još 12 patentnih zahteva.
Patent YU-44378-B (YU)
Title: Method for expanding an ion-exchanging membrane
Inventor: SMITH P J
IPC: B01D67/00
Filed: 1983-02-15
Abstract: A method of installing an ion-exchange membrane in an electrolytic cell in which the membrane is expanded by stretching to increase the surface area per unit weight of the membrane and the expanded, stretched membrane is secured to the electrolytic cell or to a part thereof. The stretching is preferably effected at elevated temperature and the expansion produced by stretching may be <<locked>> into the membrane by cooling the expanded, stretched membrane to a lower temperature prior to installation of the membrane in the electrolytic cell.
Patent ZA-90548-B (ZA)
Title: Process for grinding calcium carbonate in aqueous media
Inventor: BOUSQUET HUBERT
IPC: C08K3/24
Filed: 1990-01-25
Abstract: Process for grinding calcium carbonate in an aqueous medium in the presence of a water-soluble grinding agent in a quantity which is much smaller than that used in the prior art, which is characterised in that the grinding medium comprises grinding bodies, the aqueous phase containing the grinding agent and the calcium carbonate to be ground in suspension is maintained during the grinding operation at a temperature of less than 60 DEG C. The suspension produced by the grinding and the ground calcium carbonate collected after removal of the aqueous phase can be applied in the fields of mass filling and paper coating and of fillers for paint and plastics.
Patent ZA-91958-B (ZA)
Title: Process for preparing kraft pulp
Inventor: TIKKA PANU
IPC: D21C1/00
Filed: 1991-02-08
Abstract: Processes for preparing kraft pulp are disclosed. The processes include pretreating cellulosic material or chips with spent cooking liquor at the temperature of about 20 to 100  DEG C, followed by heating the impregnated chips at the temperature of from about 120 to 180  DEG C, followed by digestion of the lignin with white liquor, which is facilitated by using this pretreatment process.
Patent ZA-93969-B (ZA)
Title: Mixture of optically active cyclohexenone oxime ethers their preparation intermediates for this purpose and their use as herbicides
Inventor: MISSLITZ ULF
IPC: C07D239/20
Filed: 1993-02-12
Abstract: PCT No. PCT/EP93/00210 Sec. 371 Date Aug. 11, 1994 Sec. 102(e) Date Aug. 11, 1994 PCT Filed Jan. 30, 1993 PCT Pub. No. WO93/16061 PCT Pub. Date Aug. 19, 1993Mixtures of optically active cyclohexenone oxime ethers having R- and S-configuration in the oxime ether moiety of the formula I    <IMAGE>  I  (R1=C1-C6-alkyl;   <IMAGE>    <IMAGE>    <IMAGE>   X=C1-C4-alkyl, C1-C4-haloalkyl; m=0-3 or 1-4 where all X's are halogen; n=0-3 or 1-5 where all X's are halogen; R2=C1-C4-alkoxy-C1-C6-alkyl, C1-C4-alkylthio-C1-C6-alkyl, substituted or unsubstituted C3-C7-cycloalkyl, substituted or unsubstituted C5-C7-cycloalkenyl, substituted or unsubstituted 5-membered saturated heterocyclic structure, substituted or unsubstituted 6- or 7-membered heterocyclic structure, substituted or unsubstituted 5-membered heteroaromatic structure, substituted or unsubstituted phenyl or pyridyl) and their agriculturally useful salts and esters with C1-C10-carboxylic acids and inorganic acids.
Patent AT-389315-B (AT)
Title: Processes for the surface modification of polymers and their use
IPC: C08J11/06
Filed: 1987-06-09
Granted: 1989-11-27
Abstract: Finely divided polymers or other polymeric plastic materials, in particular from reclaimed waste, are surface-modified by treatment with a gaseous mixture which comprises a relatively small amount of fluorine and a relatively large amount of at least one reactive gas in an inert gaseous carrier. The treatment of the comminuted material makes this more compatible for mixing with polyfunctional, polymer-forming liquids, giving novel composite materials with controlled physical properties. The other reactive gas is preferably oxygen or a gas from the group chlorine and sulphur dioxide, with or without added oxygen.
Patent AT-389299-B (AT)
Title: Apparatus for the anaerobic purification of wastewater
IPC: C02F1/00
Filed: 1985-05-30
Granted: 1989-11-10
Abstract: An apparatus for the anaerobic purification of wastewater has a reactor through which flow passes upwards, in which reactor piping 2 is disposed for feeding the dirty water and a central scraper 1 is disposed. In order that the apparatus can be constructed simply and readily, the piping 2 for feeding the dirty water is suspended immediately above the central scraper 1, but independently of this, on a support construction 3. This support construction 3 for the piping 2 consists expediently of a carrier grid. <IMAGE>
Patent AT-401537-B (AT)
Title: Clamping device for the wearing rail on the ploughshare of a snowplough
IPC: E01H5/06
Filed: 1994-10-28
Granted: 1996-09-25
Abstract: The snowplough has a ploughshare 1, on the lower edge of which a wearing rail is releasably fixed by means of a clamping device. The clamping device has an L-shaped clamping element 5, which can be clamped against the wearing rail 3 by means of a screw 12 and the one leg 6 of which bears against the wearing rail 3 in a clamping manner. The other leg 10 of the clamping element 5, through which the screw 12 passes longitudinally, is received by a socket-like guide 14, which is fixed on the rear side of the ploughshare 1. The end of the screw 12 projecting with respect to the end face of this leg 10 is screwed into a nut 16, which is mounted in such a way that it cannot twist with respect to the guide 14. Provided on the end of the screw is a lock preventing the unscrewing of the nut 16. <IMAGE>
Patent AT-406486-B (AT)
Inventor: STARCEVIC JOVAN
IPC: C25F1/06
Filed: 1998-12-22
Granted: 2000-05-25
Abstract: Chemical and/or electrochemical pickling of high grade steel is carried out in an acidic liquid that contains no nitric acid. Consumed electrolyte solution from electrochemical neutral salt pickling lines, preferably sodium sulphate pickling lines, is added.
Patent AT-384940-B (AT)
Title: Device for the installation of frameless glass ceramic hobs
Inventor: FRENER KARL
IPC: F24C15/10
Filed: 1983-09-05
Granted: 1988-01-25
Abstract: In order to install frameless glass ceramic hobs 6 in a cutout in a worktop 4 and to equalize levels, eccentric discs 14 are rotatably mounted on the wall 3 of the cutout in the worktop 4. These eccentric discs 14 bear with their outer edge 15 from below on the horizontal leg 5 of a profiled rail 1 which has an L-shaped cross section. Profiled rail 1 and eccentric 14 are held by fixing means 12 in the form of screws which project through slots 11 in the vertical leg 2 of the profiled rail 1. The horizontal leg 5 of the profiled rail 1 forms a contact shoulder for the edge of the glass ceramic hob 6. By means of rotation of the eccentric 14 and the associated vertical adjustment of the horizontal leg 5, the intended equality of level between the worktop 4 and the actual glass ceramic hob 7 can be achieved in a straightforward manner. The sensitive edge of the glass ceramic hob 6 lies on a large area of the horizontal leg 5 of the profiled rail 1 over its entire length. <IMAGE>
Patent AT-390177-B (AT)
IPC: E05D5/06
Filed: 1984-12-20
Granted: 1990-03-26
Abstract: A fitting for a seat which can be converted into a couch, with which a pivoting cushion is articulated to a carriage and can be pivoted from the interior of the latter into a position in which the pivoting cushion, together with the seat cushion, which is mounted such that it can be pivoted upwards after the pivoting cushion has been pivoted out on the carriage, forms at least part of a couch surface, has a pivoting part 19 fastened to the carriage and a pivoting part 18 fastened to the pivoting cushion. In order to make simple and therefore cheap production of the fitting possible, both pivoting parts 18,19 are designed as short angle pieces, and that limb 22 of the pivoting part 18 fastened to the pivoting cushion which is adjacent to the pivot axis 20 projects only a short distance beyond the limb 23 of the other pivoting part 19 when the pivoting cushion is pivoted out. <IMAGE>
Patent AT-406794-B (AT)
Title: Distributor for fluids
IPC: F16L37/24
Filed: 1999-04-16
Granted: 2000-09-25
Abstract: The proposal is for a distributor for fluids, especially for heating systems, the distributor having a plurality of housings 1 that can be coupled to one another, these housings being intended, in particular, to accommodate valves, flow meters, temperature sensors etc. The housings 1 have a main passage 2 passing through them in the axial direction and at least one transverse passage 16 connected to the latter and are provided with a stub 3 that extends in the axial direction of the main passage 2, can be inserted into a widened portion 4 of the main passage 2 of the adjoining housing 1 and the circumferential surface 6 of which has at least one receptacle for a sealing ring. To enable a distributor of this kind to be assembled easily, the stub 3 has at least one radially projecting boss 7 that forms part of a bayonet joint 7, 9 and interacts with recesses 9 in the inner wall 8 of the widened portion 4, the recesses 9 having sections 10, 11 that extend in the axial direction and approximately in the circumferential direction. <IMAGE>