baber/WOPTO huggingface dataset:
Patent PL-185623-B1 (PL)
Title: Aluminium or other metal shape coloured so as to imitate wood as well as method of and apparatus for producing such colouring effect on metal shapes
Inventor: GIACOMELLI MARIO
IPC: B44F9/02
Filed: 1997-03-11
Abstract: The present invention relates to an apparatus for colouring section members and the like with a dummy wood colour, which comprises a first application station for applying on a section member polyester powders having a first colour, a second application station for applying on the section member a primer colour stabilized by polyester powders having a second colour, and a comb element for providing a vein pattern on the powders of a second colour before performing a thermal stabilizing step.
Patent PL-178412-B1 (PL)
Title: Data pack transmission in multiple-access communication systems with shared code
Inventor: CHEVILLAT PIERRE R
IPC: H04L12/56
Filed: 1995-06-14
Abstract: A method for wireless transmission of data packets in code division multiple access communication system and communication system with transmitter-receiver of a transmitting station on mobile site in a code division multiple access communication system where one of the channels with code division multiple access is used on time division basis to transmit data packets from many transmitters to a receiver characterised by a fact, that a request is sent from a transmitting station (Msy) to appropriate receiving station (BS) of a communication system, this request indicates a target address a packet or packets of data are to be directed to. This station is assigned a unique virtual connection identifier (VCIy), switches a transmitting station (Msy) to a (PRCH) channel with code division multiple access for transmitting data packets a downstream link on a code division multiple access channel (PRCH) is monitored, until a base station (BS) broadcasts that it will be free and in the next frame free access to a code division multiple access channel (PRCH) will be permitted, a power of a transmitting station (Msy) is increased during the next frame until a given power is attained, a data packet or packets and a virtual connection identifier (VCIy) are transmitted through an upstream link of a code division multiple access channel (PRCH) for transmission of data packets to a base station (BS) and a data packet or packets are redirected again to a target address with an access to code division multiple access channel (PRCH) for transmission of data packets is controlled by a multiple access protocol based on carrier detection and collision detection.
Patent PL-183418-B1 (PL)
Title: Apparatus for separating particles for particles containing liquids and method of cleaning such apparatus
Inventor: NIELSEN ARNE B
IPC: B01D21/00
Filed: 1996-09-12
Abstract: The invention relates to a device for separating particles from a particle containing liquid and comprising a separating chamber having a bottom (6) and side walls (2, 4, 5, 7), an inlet (10) for liquid with particles, an outlet (18) for the liquid essentially freed of particles, an outlet (11) for the discharge of particles, wherein at least one separating element (15), on which particles in the liquid may settle, is arranged between the inlet (10) and the outlet (18) for liquid, said liquid flowing essentially in a vertical direction between inlet and outlet, wherein the liquid outlet (18) communicates with an additional chamber (9) likewise comprising a bottom (6) and side walls (2, 3, 4, 7), wherein one side wall is formed with a liquid outlet (12) whose upper edge is provided below the level of the lower edge of the particle outlet (11). The invention moreover relates to a method, in connection with a device for separating particles from a particle containing liquid wherein the particules settle on separating elements in the device, of cleaning said device and in particular its separating elements in that a gas under pressure is supplied to the liquid in the device at a level below the lower edge of the separating elements.
Patent PL-185115-B1 (PL)
Inventor: ZILCH HARALD
IPC: A61K47/54
Filed: 1996-12-16
Abstract: 1. Fosfolipidowe pochodne kwasów fosfonokarboksylowych o ogólnym wzorze I w którym R 1 oznacza grupe -(CH2 )e-cykl, oznacza prosty lub rozgaleziony, nasycony lub niena- sycony lancuch alkilenowy, w którym e jest równy liczbie pomiedzy 4 i 16, przy czym jeden z atomów wegla od pozycji 3 moze byc zastapiony heteroatomem (tlenu, azotu lub siarki), R2 moze oznaczac atom wodoru lub prosty albo rozgaleziony, nasycony lub nienasy- cony lancuch alkilowy o 1-20 atomach wegla, R3 moze oznaczac H, sód, prosty lub rozgaleziony lancuch alkilowy o 1-6 atomach wegla, a w szczególnosci metyl, etyl, propyl, izopropyl, butyl, izobutyl, t-butyl, pentyl, he- ksyl, neopentyl, teksyl lub fenyl, choline, etanoloamine, kamityne, reszte C5 -C2 -cykloalkilowai benzylowa albo jedna z nastepujacych g ru p ................................................................................. PL PL PL PL
Patent PL-186466-B1 (PL)
Inventor: BARTH FRANCIS
IPC: A61K31/00
Filed: 1996-12-06
Abstract: 1 Nowe zwiazki, pochodne 3-pirazolokarboksyamidu o wzorze (I) w którym X1 oznacza grupe -NR1 R2 lub grupe -OR2, g2 i g6 oznaczaja atom wodoru, lub grupe (C1-C4) alkoksylowa, g3 oznacza atom wodoru, atom fluorowca, lub grape (C1-C4) aikilowa, g4 oznacza atom wodoru, atom fluorowca, grupe (C1-C4 ) aikilowa, (C1-C4) alkoksylowa, trifluorometylowa, (C1 -C4)-alkilotio, g5 oznacza atom wodoru, w2 i W 5 oznaczaja atom wodoru lub atom fluorowca, w3 oznacza atom wodoru lub atom fluorowca, w4 oznacza atom wodoru, atom fluorowca, grupe (C 1 -C4 )-aikilowa, (C1 -C4 )-alkoksy-lowa, tnfluorometylowa, w6 oznacza atom wodoru, gdy X1 oznacza grupe -NR1 R2 to R1 oznacza atom wodoru lub (C1 -C4)-alkil, R2 oznacza niearomatyczny rodnik karbocykliczny wybrany z grupy obejmujacej 1,3,3-tnmetylobicyk-lo[2 2 1]-hept-2-yl, bicyklo[2 2 1]hept-2-yl, adamant-2-yl, bicyklo[3 2 1]okt-2-yl, 2-metylo-cykloheks-1-yl, 2,6-dimetylocykloheks-1-yl, 2,2,6,6,-tetrametylocykloheks-1-yl 1 7,7-dimety-lobicyklo[4 10]hept-3-yl, gdy X1 oznacza grupe -OR2 , to R2 oznacza grupe 1,3,3-tnmetylobicykio-[2 2 1 ]-hept-2-ylowa, - R3 oznacza atom wodoru lub grupe -CH2R6, - R4 i R5 oznaczaja niezaleznie atom wodoru, lub (C1 -C4)-alkil, lub tez - R4 oznacza atom wodoru, a R5 i R6 tworza razem rodnik trimetylenowy, - R6 oznacza atom wodoru lub grupe (C1-C5) alkoksylowa, oraz jego sole PL PL PL PL PL PL PL
Patent PL-183650-B1 (PL)
Title: Tobacco swelling method
Inventor: NEVETT ROBERT
IPC: A24B3/18
Filed: 1997-02-04
Abstract: Tobacco is treated to cause its expansion by a process which comprises the steps of subjecting it, in a treatment chamber, to a reduced pressure of not greater than 7 kPa, impregnating the cell structure of the tobacco with isopentane vapour at a temperature in the range of from 70  DEG C to 100  DEG C and maintaining the tobacco in contact with the vapour at a pressure of at least 400 kPa, removing excess isopentane vapour from the treatment chamber, contacting the impregnated tobacco with steam to expand the tobacco cell structure, reducing the pressure in the treatment chamber at a rate of at least 10 kPa/minute, preferably 30 kPa/minute, and then venting the treatment chamber back to atmospheric pressure. The final filling value of the tobacco treated according to this process is directly proportional to the rate at which the pressure in the treatment chamber is reduced following the steam treatment of the tobacco.
Patent PL-190858-B1 (PL)
Title: Modified form of r(-)-n-(4,4-di (3-methylthien-2-yl) but-3-nyl) nipecotinic hydrochloride
Inventor: AHRNDT PREBEN
IPC: C07D333/10
Filed: 1997-06-03
Abstract: The present invention provides R(-)-N-(4,4-di(3-methylthien-2-yl)but-3-enyl)-nipecotic acid hydrochloride in its pure and stable anhydrous form.
Patent PL-189851-B1 (PL)
Inventor: BERGHMANS HUGO ANGELA ALBERT
IPC: C08F2/18
Filed: 1997-07-03
Abstract: 1. Sposób wytwarzania czastek polimeru zawierajacych polimer styrenu o przecietnej srednicy czastek 0,1-6 mm, znamienny tym, ze: a) miesza sie polarny polimer zdolny do absorbowania co najmniej 0,5 g wody/g su- chego polarnego polimeru ze styrenem; b) prepolimeryzuje sie styren w mieszaninie, do osiagniecia stopnia polimeryzacji 15-50%, w celu wytworzenia prepolimeryzowanej masy; c) dysperguje sie prepolimeiyzowana mase w wodnym osrodku, z wytworzeniem za- wieszonych czastek; oraz d) polimeryzuje sie zawieszone czastki w celu doprowadzenia do konca konwersji monomeru. PL PL PL PL PL PL
Patent PL-192407-B1 (PL)
Inventor: ZAK SLAWOMIR
IPC: B09B3/00
Filed: 1999-04-27
Abstract: Sposób detoksykacji odpadów organicznych zawierających trakcje tłuszczowe zawierających
ponadto związki tłuszczowe, związki i formy biogenne, metale ciężkie w postaci jonowej, kompleksowej
lub tlenkowej, zakażonych biologicznie, znamienny tym, że są one mieszane z odpadami
popiecowymi wełny mineralnej o znanym składzie oraz tlenkiem wapnia lub odpadami zawierającymi
powyżej 80% tego związku do pełnej homogenizacji i wyrównania składników w całej objętości
w proporcjach masowych odpowiednio 9 - 5 : 1 - 4 : 1 - 4, korzystnie 8 - 6 : 1 - 2 : 1 - 2 zachowaniem
sumarycznego poziomu zawartości wody w granicach 20% - 85% korzystnie 30% - 70% całkowitej
masy przygotowanych mieszanek, a następnie poddawane zestaleniu na powietrzu lub
w sposób przyśpieszony w podwyższonej temperaturze do 100°C korzystnie 70°C - 80°C.
Patent PL-192242-B1 (PL)
Title: A piece of furniture for seating convertible into a bed
Inventor: PLATTNER HERBERT
IPC: A47C17/00
Filed: 1999-06-09
Abstract: The upholstered seat frame (6) in the lying position is supported through at least one support (16) mounted at the back of the extension drawer (7), and at least one support (18) mounted at the back of the framework (2). The additional padded frame (10) is mounted to rise and fall on the extension by suitable fitments. The supports on the extension have at their end remote from the extension rollers (16) which roll down on the underneath of the seat frame when pulling out and pushing in the extension. In the sitting position the seat frame is supported on a front fascia panel (15) mounted on the extension.
Patent PL-204183-B1 (PL)
Title: Composition containing a direct cationic dye and a thickening polymer for dyeing creatine fibre
Inventor: LANG GERARD
IPC: A45D19/00
Filed: 1999-07-08
Abstract: A dye composition for keratinic fibers, especially hair, comprises at least one compound (I), (II), (III), (III') or (IV), and at least one polymeric thickener. A dye composition for keratinic fibers, especially hair, comprises at least one compound of formula (I), (II), (III), (III') or (IV), and at least one polymeric thickener, such as non-ionic, anionic or cationic amphiphilic polymers comprising at least one hydrophilic group and at least one fatty chain. D, D1, D2 = N or -CH; R1, R2 = H, 1-4C alkyl, (optionally substituted), 4'-aminophenyl or forms with a carbon of the benzene a heterocycle (optionally containing O or N and optionally substituted); R3, R'3 = H, halo, cyano, 1-4C alkyl, 1-4C alkoxy or acetyloxy; X<->, X'<-> = anion; A = a group of formula (A1); R4 = 1-4C alkyl (optionally substituted); R5 = 1-4C alkoxy; R6, R11, R12, R16, R17 = H or 1-4C alkyl; R7 = H, alkyl (optionally substituted) or 4'-aminophenyl; NR6R7 = heterocycle (optionally containing O or N, and optionally substituted); R8, R9 = H, halo, 1-4C alkyl, 1-4C alkoxy or cyano; B' = a group of formula (B'3); R, R', R10 = 1-4C alkyl; R13 = H, halo, 1-4C alkoxy or amino; R14 = H, 1-4C alkyl or forms with a carbon of the benzene a heterocycle (optionally containing O or N, and optionally substituted); R15 = H or halo; m, r = 0 or 1; E = a group of formula (E1); G = a group of formula (G1)-(G3); R18 = 1-4C alkyl, phenyl (optionally substituted by halo or 1-4C alkyl); R19, R21 = 1-4C alkyl or phenyl; R20, R31, R32 = H, 1-4C alkyl or phenyl; R20 + R21 = in (G1) a substituted benzene or in (G2) an optionally substituted benzene; Z = O, S or -NR19; M, K', P' = -CH, -CR or -NR22(X'<->)r; R22 = O-, 1-4C alkyl or 1-4C alkoxy; R23, R24 = H, halo, 1-4C alkyl, 1-4C alkoxy or nitro; J = a group of formula (J1) or 5- or 6-membered nitrogen and/or carbonyl containing heterocycle (optionally substituted), preferably a group of formula (J2); R25 = H, halo, 1-4C alkyl, 1-4C alkoxy, hydroxy, nitro, -NHR28, -NR29R30, -NHCO(1-4C alkyl); R26 = H, halo, 1-4C alkyl, 1-4C alkoxy; R27 = H, hydroxy, -NHR28 or -NR29R30; R28 = H, 1-4C alkyl, 1-4C monohydroxyalkyl, 2-4C polyhydroxyalkyl or phenyl; R25 + R26, R26 + R27, R26 + R28 = 5- or 6-membered heterocycle containing at least one N, S or O; R29, R30 = 1-4C alkyl, 1-4C monohydroxyalkyl or 2-4C polyhydroxyalkyl; Y' = -CO- or -C(CH3)=; U' = not defined; n = 0 or 1; and with provisos. The full definition is given in the Definition (Full Definition) Field. Independent claims are also included for: (1) a method of dyeing hair by applying the composition and optionally rinsing and washing; (2) a kit comprising two compartments to be mixed before application, one comprising a cationic direct colorant and optionally at least one oxidation base and the other comprising at least one oxidizing agent. One of the compartments comprises the polymeric thickener.
Patent PL-188667-B1 (PL)
Title: Apparatus for and method of removing upper portion or roots from cultivable plants
Inventor: NICHOLSON DAVID
IPC: A23N15/04
Filed: 1999-01-13
Abstract: A machine for removing roots and tops from crops including a pair of counter-rotating rollers spaced apart so as to define a nip therebetween, and means for rotating the rollers characterized in that at least one roller is in the form of a polygonal twisted prism.
Patent PL-197339-B1 (PL)
Inventor: Burza Wojciech
IPC: A01H4/00
Filed: 2000-02-25
Abstract: 1. Sposób klonalnego rozmnażania roślin przy użyciu eksplantantów pierwotnych stanowiących
izolowane stożki wzrostu pędu, zarodki, lub wtórnych stanowiących tkankę kalusową oraz merystematyczną
kulturę zawiesinowa znamienny tym, że płynną kulturę agregatów merystematycznych prowadzi
się na świetle o natężeniu co najmniej 25 nEm 2s jak i bez dostępu światła przy zastosowaniu
pożywki z cytokininą.
Patent PL-193797-B1 (PL)
Title: New treatments for nervous disorders
Inventor: HASSAN FRED
IPC: A61P25/30
Filed: 1999-04-02
Abstract: This patent application describes the treatment of Addictive Disorders, Psychoactive Substance Use Disorders, Intoxication disorders, Inhalation disorders, Alcohol addiction, Tobacco Addiction and or Nicotine Addiction; and Attention Deficit Hyperactivity Disorder (ADHD); comprising administering a therapeutically effective, nontoxic dose of Reboxetine and derivatives and or pharmaceutically acceptable salts thereof to a patient.
Patent PL-190891-B1 (PL)
Title: A container having pressure responsive panels
Inventor: MELROSE DAVID MURRAY
IPC: B65D90/02
Filed: 2000-02-24
Abstract: A container (1), suitable as a hot-fill container, includes a controlled deflection flex panel (3) which may invert and flex under pressure, such as hot-fill conditions, to avoid deformation and permanent buckling of the container (1). The flex panel (3) includes an initiator portion (8) which has a lesser projection than the remainder of the flex panel (3) and initiates deflection of the flex panel (3).
Patent PL-200009-B1 (PL)
Title: Intra eyeball pressure reducing compound as well as application of angiotensin ii antagonist for reduction of intra eyeball pressure
Inventor: YOKOYAMA TOMIHISA
IPC: A61K31/4178
Filed: 2000-06-09
Abstract: A composition for topical administration having excellent intraocular tension lowering activity is provided. ÄSolutionÜ   An intraocular tension lowering composition for topical administration comprises an angiotensin II antagonist, a boric acid and an ethylenediamine tetraacetic acid.
Patent PL-198316-B1 (PL)
Inventor: SIERADZKI ZBIGNIEW
IPC: G01D5/12
Filed: 2002-04-15
Abstract: Zadajnik magnetyczny z wielobiegunowym magnesem
i czujnikiem pola magnetycznego, znamienny
tym, że jest wyposażony w tarczę (1), na
której jednym czole jest zamocowany wielobiegunowy
magnes (2), a nadto w jej środku jest osadzony
stały magnes (3) wsparty, za pośrednictwem
łożyskowej kulki (4), o drugi stały magnes (5)
umieszczony w ścianie obudowy (6) urządzenia
elektronicznego, w której jest także umieszczony
czujnik pola magnetycznego (7)
Patent PL-200269-B1 (PL)
Inventor: SAINT-RAMON JEAN-GERARD
IPC: B65B1/04
Filed: 2002-05-07
Abstract: Fiolka dla konserwacji ma lych ilo sci sub- stancji, zw laszcza substancji biologicznych, sk ladaj aca si e z odcinka rurki wyposa zonego wewn atrz, na jednym ze swoich ko nców w ko- rek zawieraj acy proszek zeluj acy wed lug wyna- lazku charakteryzuje si e tym, ze korek zawiera mieszanin e proszku zeluj acego i, zast epuj ace- go cz esc proszku zeluj acego, materia lu nie poch laniaj acego w postaci rozproszonej, przy czym mieszanina proszku zeluj acego i materia- lu nie poch laniaj acego jest usytuowana pomi e- dzy plecionkami, albo plecionk a i os lon a, albo w os lonie lub w plecionce. PL PL PL PL
Patent PL-200512-B1 (PL)
Inventor: VICOMTE VAN AEFFERDEN BAUDOUIN
IPC: A23L13/40
Filed: 2001-02-22
Abstract: Wynalazek dotyczy sposobu przyprawiania produktów spo zywczych, takich jak drób, cz esci drobiu, mi eso, ryby, warzywa i dania z makaronem, w którym przyprawy i sól laczy si e z t luszczem stalym w temperaturze pokojowej, przy czym sól stosuje si e w ilo sci 15 - 67% wagowych w przelicze- niu na mas e mieszaniny przyprawowej i uzyskan a mieszanin e ogrzewa si e a z do up lynnienia t luszczu, po czym nanosi si e j a na produkt spo zywczy. Wynalazek dotyczy równie z sposobu przyprawiania produktów spo zywczych, takich jak drób, cz esci drobiu, mi eso, ryby, warzywa i dania z makaronem, w którym przyprawy i sól laczy si e z materia lem wybranym z grupy obejmuj acej hydrokoloidy, zelaty- n e, srodki emulguj ace i w eglowodany, przy czym sól stosuje si e w ilo sci 20 - 45% wagowych w przeli- czeniu na mas e mieszaniny przyprawowej i uzyskan a mieszanin e up lynnia si e oraz nanosi na produkt spo zywczy. PL PL PL PL
Patent PL-197189-B1 (PL)
Inventor: SOBOLEWSKI ANDRZEJ
IPC: D03D41/00
Filed: 2003-09-03
Abstract: 1. Urządzenie do formowania maty z włókien
krótkich, znamienne tym, że składa się
z sita perforowanego (1) w kształcie litery mała
omega ω oraz z dwóch, umieszczonych wewnątrz
sita perforowanego (1), obracających
się wirników (2).
Patent PL-197772-B1 (PL)
Inventor: CWIERTKA JOZEF
IPC: D02G3/36
Filed: 2003-12-01
Abstract: Sposób wytwarzania przędzy rdzeniowej polegający
na zgrzebleniu i formowania runa z włókien naturalnych
i chemicznych na zgrzeblarce, znamienny tym, ż e runo (1)
zbierane urządzeniem zdejmującym (2) w procesie ciągłym
z bę bna zbieracza (3) zgrzeblarki, odprowadza się w kierunku
poprzecznym do kierunku obrotu (4) bębna zbieracza (3)
w przybliżeniu równolegle do jego osi obrotu bębna (5) oraz
prowadzi się w kierunku jednej z krawędzi bocznych (6)
tego bębna zbieracza (3), następnie z pobliża krawędzi
bocznej (6) wprowadza się zbierane runo (1) wraz z prowadzonym
równolegle do tego zbieranego runa (1) sznurkiem
rdzenia (7), składającego się co najmniej z jednego sznurka,
do otworu przelotowego (8) obracającego się wokół
własnej osi urządzenia owijającego (9), mieszczącego się
w pobliżu tej jednej z krawędzi bocznych (6), przy czym
urządzenie owijające (9) korzystnie stanowi obracającą się
wokół własnej osi tulejkę (10) z otworem przelotowym (8),
z tym że w urządzeniu owijającym (9) nieprzerwanie przemieszczające
się w jego otworze przelotowym (8) runo (1)
owija się wokół sznurka rdzenia (7), po czym gotową przędzę
rdzeniową (11) przemieszcza się między parą wałków
urządzenia przenoszącego (12), za którym gotowa przędza
rdzeniowa (11) nawija się na nawój przędzalniczy (13).
Patent PL-215304-B1 (PL)
Title: Process for the preparation of azoxystrobin and analogues thereof
Inventor: JACKSON DAVID ANTHONY
IPC: C07D239/34
Filed: 2002-05-03
Abstract: A process for the preparation of a compound of the general formula (I): wherein R<1> is a 4-pyrimidinyl ring substituted at the 6-position by halo, hydroxy, 2-cyanophenoxy, 2,6-difluorophenoxy, 2-nitrophenoxy or 2-thiocarboxamidophenoxy and R<2> is any group which can be transesterified to form a methyl ester, which comprises treating a compound of general formula (II): wherein R<1> and R<2> have the meanings given above, with a formylating agent and subsequently treating the formylated product with a methylating agent.
Patent PL-204137-B1 (PL)
Title: Aromatic herb preparation
Inventor: VAN AEFFERDEN BAUDOUIN
IPC: A23L27/10
Filed: 2002-12-03
Abstract: The invention relates to a preserved preparation consisting of at least one aromatic herb, having a content of at least one composition that sets the water activity of the preparation at 0.90 or less. The preparation also has a content of at least one substance that increases the pH value of the preparation by at least 1.0 point compared to the pH value of the aromatic herb (aromatic herbs) after adding the composition that sets the water activity, whereby the preparation additionally contains at least one antioxidant and/or is packaged while being isolated from oxygen.
Patent PL-202666-B1 (PL)
Title: Control mechanism for the extension units in the longwall face of a mine
Inventor: KUSSEL WILLI
IPC: E21D23/14
Filed: 2003-12-11
Abstract: Disclosed is a control mechanism for controlling the movements of the extension units and driving in a longwall face of a mine. Said control mechanism comprises a plurality of control units, one of which (shield control unit) is topically and functionally assigned to each extension unit. Each shield control unit is provided with a multichannel radio transceiver via which one of the shield control units is in simultaneous transmit mode and receive mode with a decentralized portable operator device in order to transmit test data and status data. The shield control units are programmed in such a way that incoming radio control signals can be converted into functions of the extension unit only if the control signal is provided with the code word allocated to the called shield control unit. Preferably, the shield control units are interlinked by means of two bus lines (58, 59) used for transferring input data to all shield control units. Each shield control unit encompasses an amplifier for regenerating the signals that come in via a bus line.
Patent PL-219741-B1 (PL)
Title: Polymer conjugates of interferon-beta with enhanced biological potency
Inventor: SAIFER MARK G P
IPC: A61P35/00
Filed: 2003-12-23
Abstract: Methods are provided for the synthesis of polymer conjugates of cytokines and receptor-binding antagonists thereof, especially a non glycosylated interferon-beta, which conjugates retain unusually high biological potency. Preparation of polymer conjugates according to the methods of the present invention diminishes or avoids steric inhibition of receptor-ligand interactions that commonly results from the attachment of polymers to receptor-binding regions of cytokines, as well as to agonistic and antagonistic analogs thereof. The invention also provides conjugates and compositions produced by such methods. The conjugates of the present invention retain a high level of biological potency compared to those produced by traditional polymer coupling methods that are not targeted to avoid receptor-binding domains of cytokines. In assays in vitro, the biological potency of the conjugates of non-glycosylated interferon-beta of the present invention is substantially higher than that of unconjugated interferon-beta and is similar to that of interferon-beta-1a that is glycosylated. The conjugates of the present invention also exhibit an extended half-life in vivo compared to the corresponding unconjugated cytokine. The present invention also provides kits comprising such conjugates and/or compositions, and methods of use of such conjugates and compositions in a variety of diagnostic, prophylactic, therapeutic and bioprocessing applications, including treatment of multiple sclerosis.