Patent SG-11201805506Y-A (SG)
Title: Modulators of 5'-nucleotidase, ecto and the use thereof
Inventor: DEBIEN LAURENT
IPC: A61K31/7076
Filed: 2017-01-06
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization IIIMI41101110101011111 HO 1111101110111 0101111110011111110111110 ill OEN International Bureau ... ..... ..Yi j (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/120508 Al 13 July 2017 (13.07.2017) WI P0 I P CT (51) International Patent Classification: KALISIAK, Jaroslaw; 1031 Crestview Drive, Apt. 104, A61K 31/70 (2006.01) C07H 19/16 (2006.01) Mountain View, CA 94040 (US). LAWSON, Kenneth V.; A61K 31/7052 (2006.01) C07H 19/20 (2006.01) 1221 Masonic Avenue, #10, San Francisco, CA 94117 A61K 31/7076 (2006.01) CO7H 19/207 (2006.01) (US). LELETI, Manmohan Reddy; 7269 Ventana Drive, (21) International Application Number: West San Jose, CA 95129 (US). LINDSEY, Erick, Allen; PCT/US2017/012587 44 Burnham Place, Fremont, CA 94539 (US). MILES, Dillon Harding; 2320 Haste Street, #14, Berkeley, CA (22) International Filing Date: 94074 (US). NEWCOMB, Eric; 825 Live Oak Avenue, 6 January 2017 (06.01.2017) Unit K, Menlo Park, CA 94025 (US). POWERS, Jay (25) Filing Language: English Patrick; 745 Rockaway Beach Avenue, Pacifica, CA 94044 (US). ROSEN, Brandon Reid; 2321 Hacienda (26) Publication Language: English Street, San Mateo, CA 94403 (US). SHARIF, Ehesan Ui; 1793 Santa Cruz Avenue, Menlo Park, CA 94025 (US). (30) Priority Data: 62/276,564 8 January 2016 (08.01.2016) US (74) Agents: KEZER, William B. et al.; Mintz Levin Cohn 62/324,077 18 April 2016 (18.04.2016) US Ferris Glovsky And Popeo, P.C., One Financial Center, Boston, MA 02111 (US). (71) Applicant: ARCUS BIOSCIENCES, INC. [US/US]; 3928 Point Eden Way, Hayward, CA 94545 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (72) Inventors: DEBIEN, Laurent, Pierre Paul; 461 Andover AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, Street, San Francisco, CA 94110 (US). JAEN, Juan, Car- BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, los; 154 Los Robles Drive, Burlingame, CA 94010 (US). [Continued on next page] = (54) Title: MODULATORS OF 5'-NUCLEOTIDASE, ECTO AND THE USE THEREOF (57) : Compounds that modu- FIG. = 1 late the conversion of AMP to aden- osine by 5'- nucleotidase, ecto, and = — compositions containing the com- pounds and methods for synthesizing the compounds, are described herein. = The use of such compounds and com- positions for the treatment and/or pre- diverse diseases, = Extracellular ....N vention of a array of disorders and conditions, including cancer- and immune-related disorders, . ATP ADP AMP Adenosine that are mediated by 5'-nucleotidase, = 2 is also 0 ilo. _3_ 0. ecto provided. = 0 0 31 © 0 0 Outer Membrane = = Pannexin-'71 -- _ ‘...../ P2X ATP P2Y & ` \--=/ AR --/ \S Inner Membrane 1-1 Intracellular Ot 0 in 0 1. Ecto-nucleotide pyrophosphatase/ phosphodiesterase (E-NPP) 2. Ecto-nucleoside triphosphate diphosphydrolase (E-NTDPase) 3. Ecto-5'-nuclrotidase/CD73 ei ,-1 IN ,-1 © ei O WO 2017/120508 Al MIDEDIMOMOIDEIROIDEOMMMIIMEMOMEHMIE DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, RU, KZ, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, LY, NA, TJ, TM), European (AL, AT, BE, BG, CH, CY, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, CZ, IT, RS, SE, DE, LT, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, ZA, ZM, ZW. SV, VC, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). GA, Published: (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, with international search report (Art. 21(3))