baber/WOPTO huggingface dataset:
Patent MX-2021003808-A (MX)
Title: Azithromycin and roxithromycin derivatives as senolytic drugs.
Inventor: LISANTI MICHAEL P
IPC: A61K31/7042
Filed: 2019-10-02
Abstract: This disclosure describes the use of azithromycin, roxithromycin, and telithromycin, including derivatives thereof, as senolytic drugs. BrdU was used to induce senescence in model human fibroblast cell lines. Also disclosed are methods for screening compounds for senolytic activity. The SRB assay was used to measure cell viability through protein content. Azithromycin roxithromycin, and telithromycin, clinically-approved pharmaceuticals, were found to be senolytic drugs. However, the closely-related parent compound, erythromycin, showed no senolytic activity. Azithromycin strongly induced both aerobic glycolysis and autophagy in human fibroblasts, but showed bi-phasic effects including on mitochondrial oxygen consumption rates with inhibitory activity at 50 Î¼Î and stimulatory activity at 100 Î¼Î. The xCELLigence real-time assay system showed that azithromycin preferentially targets senescent cells, removing approximately 97% (nearly a 25-fold reduction in senescent cells).
Patent MX-2021004284-A (MX)
Title: Anti-npr1 antibodies and uses thereof.
Inventor: MASTAITIS JASON
IPC: C07K16/28
Filed: 2019-10-18
Abstract: The present invention provides monoclonal antibodies that bind to the natriuretic peptide receptor 1 (NPR1) protein, and methods of use thereof. In various embodiments of the invention, the antibodies are fully human antibodies that bind to NPR1. In some embodiments, the antibodies of the invention are useful for activating NPR1 activity, thus providing a means of treating or preventing a disease, disorder or condition associated with NPR1 in humans.
Patent MX-2021005055-A (MX)
Title: Bacterial compositions and methods for controlling plant pests and improving plant health.
Inventor: GACHANGO ESTHER
IPC: A01P7/00
Filed: 2019-10-29
Abstract: Compositions and methods for controlling plant pests and/or improving at least one agronomic trait of interest in a plant are provided. Such compositions and methods comprise a bacterial strain that can be used as an inoculant for plants. Therefore, methods for growing a plant susceptible to a plant pest and/or plant disease caused by a plant pest and methods for controlling plant pests and/or plant disease on a plant susceptible to the plant pest and/or plant disease are also provided.
Patent MX-2021005657-A (MX)
Title: Machine tooling with rotary punch.
Inventor: MALONEY MICHAEL
IPC: F16B19/04
Filed: 2019-11-12
Abstract: A tooling system has means for applying a vacuum to hold the fastener at the working end of the tool. A cavity in a hollow pusher pin has lateral ports for exclusively providing a airway between the vacuum source and the fastener. In other embodiments of the invention the pusher pin has fastener-gripping jaws in the form of balls moveable within lateral passageways in the pusher pin open into the cavity. The balls are biased inwardly against the fastener by an outer elastic band on the tool body which encircles the pusher pin. When adapted for installing magnetic-release type fasteners, the bottom end of the pusher pin is of reduced diameter for insertion into a magnetic release fastener. The fastener-receiving panel is supported by an anvil having a magnet whereby the fastener is released from the pusher pin as the fastener is pressed into the panel.
Patent MX-2021005868-A (MX)
Title: Pivot hinge.
Inventor: MITCHELL BRETT
IPC: E05D5/00
Filed: 2021-05-18
Abstract: A pivot hinge includes a spring housing with a central tube, a spring assembly, an upper mounting plate, and a lower mounting plate. A pivot pin is positioned within the central tube and is coupled to a torsion spring. A top end of the pivot pin is received within a central channel of a spring bushing. The spring bushing has a cylindrical main portion and a undulating ridge forming three radially positioned high areas or tongues and three radially positioned low areas, troughs or grooves. The grooves are configured to receive or mesh with interior steps in the central tube to prevent relative rotation between the spring bushing and the central tube Each tongue also includes a spring mounting recess therein. The top end of the cylindrical main portion extends through and is journalled within the top opening of the central tube.
Patent MX-2021008483-A (MX)
Title: Inhalation chamber.
Inventor: BRICHET-BILLET ETIENNE
IPC: A61M16/20
Filed: 2020-01-14
Abstract: The present invention concerns an inhalation chamber (1) comprising a body (10) having an inlet orifice suitable for being connected to the outlet end piece of a metering aerosol, and an outlet orifice (12) suitable for being connected to a mouthpiece (30) or a mask (3) to be applied on the face of a patient, and a support (13) suitable for receiving the outlet end piece (20) of the metering aerosol (2), the support (13) opening into the inlet orifice, characterised in that the axis (X) of the inlet orifice this is not co-linear with the axis (Y) of the outlet orifice and in that the support is mounted on the body (10) to pivot about the axis (X) of the inlet orifice.
Patent MX-2021008542-A (MX)
Title: Methods and systems for producing aav particles.
Inventor: CARDINAL JACOB J
IPC: C12N15/86
Filed: 2020-01-17
Abstract: The present disclosure describes methods and systems for use in the production of adeno-associated virus (AAV) particles, comprising recombinant adeno-associated virus (rAAV) particles. In certain embodiments, the production process and system use Sf9 insect cells as viral production cells. In certain embodiments, the production process and system use Baculoviral Expression Vectors (BEVs) and Baculoviral Infected Insect Cells (BIICs) in the production of AAV particles.
Patent MX-2021011668-A (MX)
Title: Self-sustainable urinary catheter.
Inventor: VILAR CORREIRA LIMA SALVADOR
IPC: A61F2/00
Filed: 2021-09-24
Abstract: Urinary catheter (1) comprising three discs, a fixed proximal disc (2) having a protrusion (2A); a distal disc (3) having a protrusion (3A) and a distal disc (3B), wherein the discs (3, 3B) are sliding; the distal end (9) of the catheter (1) has a connector (10) with a lid (11) and an opening and closing mechanism; the chuck (M) features a rod-shaped portion (M1) dimensioned to be introduced along the tubular body (5) of the catheter (1); an enlarged distal portion (M2) matches, when touching the connector end (10), with its end (M3), reaching the final point of the closed proximal end (4) of the catheter (1); and a handle portion (M4); the proximal end (4) of the tubular body (5) of the catheter (1) includes four orifices (6) and two orifices (6A); the orifices (6A) are positioned closest to the proximal disc (2) and positioned diametrically opposed.
Patent MX-2021012306-A (MX)
Title: Low cost extrudable isolator from slit-tape.
Inventor: HOPKINSON WAYNE C
IPC: H01B13/24
Filed: 2020-03-30
Abstract: A dielectric isolator for a twisted pair cable includes a body formed as an elongate strip with a top surface, bottom surface, a first side edge and a second side edge. A first slot is formed in the first side edge and extends at least half way toward the center of the isolator. A second slot is formed in the second side edge and extends at least half way toward the center of the isolator. During cable manufacturing, first and second wedges open the first and second slots. First and second twisted pairs are inserted into the first and second opened slots, respectively. Third and fourth twisted pairs reside at the top and bottom surface, respectively. The isolator has the cost and reel storage savings of a flat separator tape, while simultaneously providing the internal crosstalk performance of the isolator.
Patent MX-2021013983-A (MX)
Title: Single-channel sequencing method based on self-luminescence.
Inventor: CHEN XI
IPC: C12Q1/6869
Filed: 2019-05-15
Abstract: The present invention provides a sequencing method based on a single fluorescent dye, comprising using self-luminous signals for distinguishing the sequential incorporation of different nucleotides, thereby realizing the determination of a polynucleotide sequence.
Patent MX-2022001180-A (MX)
Title: High-strength steel sheet, high-strength member, and methods respectively for producing these products.
Inventor: KANEKO SHINJIRO
IPC: C21D9/46
Filed: 2020-07-29
Abstract: The present invention addresses the problem of providing: a high-strength steel sheet having excellent material uniformity; a high-strength member; and methods respectively for producing the high-strength steel sheet and the high-strength member.ãThe high-strength steel sheet of the present invention has a specified component composition, wherein ferrite makes up 30 to 100% by area inclusive, martensite makes up 0 to 70% by area inclusive and the sum total of perlite, bainite and retained austenite makes up less than 20% by area each relative to the whole area of the steel structure, non-recrystallized ferrite, among the ferrite, makes up 0 to 10% by area inclusive relative to the whole area of the structure, and the difference between a largest value and a smallest value of the area ratio of the non-recrystallized ferrite as observed in the direction of the length of the steel sheet is 5% or less.
Patent MX-2022001971-A (MX)
Title: Modified interleukin 2 (il-2) polypeptides, conjugates and uses thereof.
Inventor: XU XIAO
IPC: C07K14/55
Filed: 2020-08-11
Abstract: This disclosure relates to modified interleukin 2 (IL-2) polypeptides, polynucleotides, <i>e.g.</i>, DNA, RNA or viral vector, that encode the modified IL-2 polypeptides and are configured to express said modified IL-2 polypeptides <i>in vitro</i> and/or <i>in vivo</i>, conjugates comprising the modified IL-2 polypeptides, and uses thereof.
Patent MX-2022003093-A (MX)
Title: Method for whitening tobacco.
Inventor: ZAWADZKI MICHAEL ANDREW
IPC: A24B13/00
Filed: 2020-09-09
Abstract: A method of preparing a whitened tobacco material for use in a smokeless tobacco product, including: (i) extracting a tobacco material with an aqueous solution to provide a tobacco solids material and a tobacco extract; (ii) bleaching the tobacco solids material with a solution comprising a strong base, an oxidizing agent, or a combination thereof to provide a bleached tobacco material; and (iii) drying the bleached tobacco material to provide the whitened tobacco material; wherein the tobacco solids material is not subjected to treatment at an elevated temperature with sulfur-containing reagents, organic solvents, sodium hydroxide, or an acid between the extraction and the bleaching.
Patent MX-2022003694-A (MX)
Title: Glass with function of regulation in sections and system for regulating glass in sections.
Inventor: WANG LU
IPC: G02F1/153
Filed: 2020-09-27
Abstract: The present disclosure provides a glass (G2) with a function of regulation in sections, a system for regulating a glass (G2) in sections and a method for regulating a glass (G2) in sections. The glass (G2) with a function of regulation in sections according to the present disclosure comprises a glass body (110) and a conductive component (120). The glass body (110) comprises a glass substrate (130) and a functional component (140) attached to the glass substrate (130) and divided into sections capable of being individually regulated. The conductive component (120) is coupled to each section of the functional component. The conductive component (120) comprises a flexible printed circuit (1220) and a conductive adhesive (1210). The flexible printed circuit (1220) comprises a conductive trace (1221) electrically connected to each section of the functional component via the conductive adhesive (1210) to allow an individual regulation of each section of the functional component. The glass (G2) with a function of regulation in sections according to the present disclosure is capable of regulating a function of a target section of the functional component according to a user's instruction and an environmental parameter.
Patent MX-2022006570-A (MX)
Title: Process for synthesis of a 2-(5-isoxazolyl)-phenol.
Inventor: HONG JUNBAE
IPC: C07D261/08
Filed: 2020-12-02
Abstract: A method for preparing a compound of Formula (1) and compounds therefrom, comprising treating a compound of Formula (2) to provide a compound of Formula (5) and treating the compound of Formula (5) with a hydroxylamine salt wherein R<sup>1</sup>, R<sup>2</sup> and m are as defined in the specification. The compound of Formula (1), prepared by the above method, can be used to prepare a compound of Formula (8) wherein R<sup>1</sup>, R<sup>2</sup>, R<sup>3</sup> and m are as defined in the specification.
Patent MX-2022008433-A (MX)
Title: Plants showing a reduced wound-induced surface discoloration.
Inventor: VAN DUN CORNELIS MARIA PETRUS
IPC: A01H5/12
Filed: 2018-08-15
Abstract: The present invention relates a plant comprising a modified <i>F5H</i> gene homolog, wherein said gene homolog comprises a modification as compared to its corresponding wild type <i>F5H</i> gene homolog, wherein the presence of the modified <i>F5H</i> gene homolog in the plant leads to a reduction of wound-induced surface discoloration in comparison to a plant not comprising the modified <i>F5H</i> gene homolog. The invention also relates to a modified <i>F5H</i> gene homolog that leads to the reduced wound-induced surface discoloration. The invention further relates to use of the gene in breeding and producing plants that show reduced wound-induced surface discoloration.
Patent MX-2022008957-A (MX)
Title: Improved solvents for acetylene fluid storage.
Inventor: SINHA ASHWINI K
IPC: C10L3/04
Filed: 2021-02-18
Abstract: A composition comprising acetylene fluid at least partially solubilized in an improved solvent is described. The improved solvents exhibit non-toxicity and are further characterized by low vapor pressures to minimize solvent carryover during delivery of the acetylene fluid, while retaining suitable acetylene solubilizing capacity.
Patent MX-2022010944-A (MX)
Title: Eif4e inhibitors and uses thereof.
Inventor: OR YAT SUN
IPC: A61P35/00
Filed: 2021-03-03
Abstract: The present invention provides compounds inhibiting elF4E activity and compositions and methods of using thereof.
Patent MX-2022011313-A (MX)
Title: Improved tungsten-containing anti-microbial composite materials.
Inventor: GUGGENBICHLER JOSEF PETER
IPC: A01N59/16
Filed: 2021-03-17
Abstract: The invention relates to the use of tungsten blue as an antimicrobial agent, composite materials comprising tungsten blue and methods for the production thereof.
Patent MX-2022012150-A (MX)
Title: Process for producing a meat analogue and apparatus therefor.
Inventor: SCHLEBUSCH JOHANNES PAUL
IPC: A23J3/04
Filed: 2021-04-01
Abstract: The present invention relates to a process for the production of a meat analogue, comprising the steps of: a) introducing a meat batter comprising protein into a heating unit and heating the meat batter to a temperature above the melting point of the protein to produce a heat-treated product, wherein the heating unit optionally heats the meat batter by Ohmic heating, b) cooling the heat-treated product by moving through a cooling unit, so that the heat-treated product has a temperature below water boiling temperature at ambient pressure when exiting the cooling unit, and c) dividing the cooled heat-treated product into pieces and optionally d) tearing the pieces by passing the pieces through a roll nip (14) between a pair of counter-rotating cylindrical rolls (2, 4) having parallel axes of rotation (10, 12), a plurality of projections (16) being arranged on an outer surface of at least one of the rolls (2, 4).
Patent MX-2022013334-A (MX)
Title: Pd-1 agonist multimeric binding molecules.
Inventor: KEYT BRUCE
IPC: C07K16/28
Filed: 2021-04-21
Abstract: This disclosure provides multimeric binding molecules that specifically and agonistically bind to programmed cell death protein 1 (PD-1). This disclosure also provides compositions comprising the multimeric binding molecules, polynucleotides that encode the multimeric binding molecules, and host cells that can produce the binding molecules. Further this disclosure provides methods of using the multimeric binding molecules, including methods for treating autoimmune disorders and preventing transplantation rejection.
Patent MX-2022014656-A (MX)
Title: Driverless transport vehicle having a payload lifting apparatus.
Inventor: MAINZ SVEN
IPC: B66F9/065
Filed: 2021-05-10
Abstract: The invention relates to a driverless, in particular automatically guided transport vehicle (1) for conveying payloads, in particular a material transport vehicle in a plant, having a payload lifting apparatus (2). For a particularly cost-effective and still stiff and efficient structure of the lifting apparatus (2), according to the invention the lifting process is realized by means of an eccentric drive.
Patent MX-NL05000054-A (MX)
Title: Organic compound with a nematicidal action obtained from water-soluble creosote bush (larrea tridentata) extracts.
Inventor: CARDENAS LUIS ALBERTO VILLARRE
IPC: C05F11/10
Filed: 2005-06-23
Abstract: The present invention refers to the use of water-soluble L. tridentata resin extracts as environmentally friendly nematicides useful in diverse crops including the Solanaceae, Leguminous, Cucurbitaceae, Amaryllidaceae and Compound families amongst others. An application method is further included, which is based in pressurised irrigation methods such as dripping or spraying, or by means of a backpack or mechanical drive sprayer. The inventive mixtures may be used alone or as a part of a formulation including further agrochemical products such as growth regulators, pesticides, fertilizers or nutrients. Said mixtures may be applied in powder or in aqueous solutions at different concentrations depending on the type of nematodes to be removed and the results to be obtained.
Patent MX-PA00000182-A (MX)
Title: Red-dyeing dye mixtures of water-soluble fiber-reactive azo dyes and their use.
Inventor: RONALD PEDEMONTE
IPC: C09B67/22
Filed: 2000-01-03
Abstract: Described are dye mixtures of dyes of the general formulae (1) and (2) where M is hydrogen, an alkali metal or the equivalent of an alkaline earth metal, R1, R2 and R3 are independently hydrogen or sulfo, X1 and X2, are independently chlorine, fluorine, hydroxy, alkoxy of 1 to 4 carbon atoms, optionally substituted phenyl, optionally substituted morpholino, optionally substituted pyrimidino, cyanoamino or an amino group of the formula -NR4R5, where R4 is hydrogen, alkyl of 1 to 4 carbon atoms, unsubstituted or sulfo-substituted phenyl or unsubstituted or sulfo-substituted naphthyl, R5 is hydrogen, optionally substituted alkyl, which may be interrupted by oxy or amino, or optionally substituted phenyl or unsubstituted or sulfo-substituted naphthyl, or the group -NR4R5 is the radical of an aliphatic heterocycle, the groups Y1-SO2-, Y2-SO2- and Y3-SO2- are each a fiber-reactive radical of the vinyl sulfone series and are attached to the benzene nucleus meta or para to the azo group.
Patent MX-PA00005309-A (MX)
Title: Myt1 kinase inhibitors.
Inventor: MARIA A LAGO
IPC: C07D277/38
Filed: 2000-05-30
Abstract: The present invention provides novel receptor antagonists of myt1 kinase and methods for using them.
Patent MX-PA00007275-A (MX)
Title: Group iv-a protective films for solid surfaces.
Inventor: TOMLINSON CHARLES E
IPC: C23C22/56
Filed: 1998-11-20
Abstract: Compositions and processes are disclosed for producing improved electrical insulation, environmental protection, corrosion resistance and improved paint adhesion for metals; e.g., ferrous, aluminum, or magnesium alloys; as well as other substrates such as anodized metals, glasses, paints, plastics, semiconductors, microprocessors, ceramics, cements, silicon wafers, electronic components, skin, hair, and wood upon contact. The compositions and processes comprise use of one or more Group IV-A metals, such as zirconium, in combination with one or more non-fluoanions while fluorides are specifically excluded from the processes and compositions above certain levels. The processes can contain pretreatment stages that serve to activate a substrate surface and/or promote formation of metal- and mixed-metal oxide matrices through use of an oxygen donor. The compositions are at a pH below about 5.0 and are preferably in a range between about 1.0 and about 4.0. The coatings may contain additives such as surfactants, sequestering agents, or other organic additives for improved corrosion protection and paint adhesion. The substrate may be treated by immersion, spray, fogging or rollcoat and other common application techniques.
Patent MX-PA00010326-A (MX)
Title: Cutting device for an agricultural harvesting machine.
Inventor: RAYMOND UROS
IPC: A01F15/10
Filed: 2000-10-20
Abstract: A baler for making large cylindrical bales is equipped with a cutting device for cutting picked up crop into pieces before it enters the baling chamber. The cutting device includes a plurality of cutting knives that are pivotable about a horizontal transverse axis between an working position for cutting crop, wherein the knives each project upwardly through respective slits provided in a guide sheet, and a non-working position wherein the knives are withdrawn to a non-working position substantially below the guide sheet. A plurality of knife positioning elements are respectively associated with the knives and mounted for pivoting about a second horizontal transverse axis such that when the positioning elements are in a first position corresponding to the working position of the knives rollers respectively carried by the positioning elements are in engagement with a recess in a surface provided on the rear of the associated knife. The positioning elements are biased such that the rolle r carried by a given positioning element will remain in the recess of the associated knife so long as the force tending to rock the knife to its non-working position is below a predetermined amount. Once this force is exceeded, the knife will pivot to its non-working position until the force once again falls below the predetermined amount. A sensing device is associated with a warning or indicator circuit for letting the operator know when one of the knives has moved to a position not occupied by the remaining knives.
Patent MX-PA00011480-A (MX)
Title: Trapped object release system for a transit vehicle door.
Inventor: PHILIP J CALAMATAS
IPC: E05F13/00
Filed: 2000-11-22
Abstract: Method of facilitating release of an object caught by one or more closing transit vehicle door(s) in a motorized door system having a two stage lock, the two stage lock having a fully locked position and a pushback lock position. The method includes detecting the presence of the object by the effect of the object on either the position or the velocity of the door(s). The method also includes determining whether the door(s) are in a pushback range between the fully locked position and the pushback lock position. If an object is detected and the door(s) are in the pushback range, then one or more signals are supplied to a motor of the door(s) to move the door(s) in the door opening direction to or toward the pushback lock position.
Patent MX-PA01000532-A (MX)
Title: Conveyor belt with carrier tissue in which conductive loops are embedded.
Inventor: DANIEL CERVERA
IPC: B65G43/02
Filed: 1999-07-08
Abstract: The invention relates to a belt, strap, conveyor belt (20) with a carrier tissue (2) in which at least one electrically conductive loop (4) is embedded. The conductive loop is sawn on the carrier tissue (2) so that conveyor belts (20) with conductive loops having an extremely thin cover layer (22) may also be provided.