baber/WOPTO huggingface dataset:
Patent DO-P2015000058-A (DO)
Title: Derivados tricíclicos de quinolinas y de quinoxalinas
Inventor: HAUPT ANDREAS
IPC: C07D487/06
Filed: 2015-03-13
Abstract: Derivadostricíclicos de quinolinas y de quinoxalinas. Composiciones far-macéuticas que los comprenden. Su uso como moduladores del receptor 5-HT2c, especialmente como agonistas o agonistas parciales. Su uso en la elabo-ración de medicamentos útiles para prevenir o tratar aquellas afecciones y aquellos trastornos que pueden responder a la modulación del receptor 5-HT2c. Método para prevenir o tratar aquellas afecciones y aquellos trastornos que pueden responder a la modulación del receptor 5-HT2c.
Patent DO-P2017000255-A (DO)
Title: Compuestos nucleósidos 5-sustituidos
Inventor: BRIAN MORGAN WATSON
IPC: C07D487/04
Filed: 2017-10-30
Abstract: La presente invención se refiere a compuestos nucleósidos 5'-sustituidos novedosos, composiciones farmacéuticas que comprenden los compuestos, y métodos de utilización de los compuestos para tratar el cáncer, más particularmente para el tratamiento del cáncer, en particular los glioblastomas, melanoma, sarcomas, cáncer gástrico, cáncer de páncreas , colangiocarcinoma, cáncer de vejiga, cáncer de mama, cáncer de pulmón de células no pequeñas, leucemias, incluyendo leucemia mieloide aguda y los linfomas .
Patent EC-SP10010032-A (EC)
Title: derivados de azaciclilisoquinolinona e -isoindolinona como antagonistas de la HISTAMINA-3
Inventor: ZHOU DAHUI
IPC: A61K31/4025
Filed: 2010-03-12
Abstract: RESUMEN DE LA INVENCIÓN La presente invención proporciona un compuesto de fórmula I y su uso para el tratamiento de un trastorno del sistema nervioso central relacionado con, o que se ve afectado por, el receptor de la histamina-3.
Patent EC-SP13012710-A (EC)
Title: Método de tratamiento con inhibidores selectivos de bcl-2
Inventor: GHAYUR TARIQ
IPC: A61P37/00
Filed: 2013-06-21
Abstract: Métodos de tratamiento de lupus eritematoso sistémico, nefritis lúpica o síndrome de Sjogren con compuestos que inhiben selectivamente la actividad de las proteínas anti apoptóticas Bcl 2. Específicamente, la presente invención está dirigida al tratamiento con compuestos que inhiben selectivamente la actividad de proteínas Bcl-2, con una menor afinidad por la inhibición de la actividad de otras proteínas de la familia Bcl-2, incluyendo Bcl- xL.
Patent EE-200000654-A (EE)
Inventor: JOSHI RAJENDRA KUMAR
IPC: A61K38/13
Filed: 1999-08-20
Abstract: The invention relates to the use of certain fumaric acid monoalkyl esters as salts or a free acid either alone or in combination with a dialkyl fumarate for producing pharmaceutical preparations for use in transplantation medicine, especially for treating, alleviating or suppressing host-versus-graft reactions. For this purpose, the fumaric acid monoalkyl esters may be used in combination with preparations conventionally used in transplantation medicine and immuno suppressives, especially such as cyclosporines.
Patent GB-189606210-A (GB)
Title: Improvements in Apparatus for Charging Metallurgical and other Furnaces.
Inventor: WELLMAN SAMUEL THOMAS
Filed: 1896-03-20
Granted: 1897-02-13
Abstract: 6210. Wellman, S. T., and Wellman, C. H. March 20. Cranes for charging furnaces. In this apparatus the furnace is charged through gearing operated by electricity, the charging-box is retracted and deposited, another box is raised, and its contents are deposited in another furnace, and so on. Fig. 1 represents a side view of the charging-apparatus with a transverse section of a melting-furnace with the charging- bar and charge box inserted therein, and Fig. 5 a vertical transverse section on the line 5-5, Fig. 1. The main carriage 3, supported by wheels 1 running on rails in front of the row of furnaces, is provided with the upper carriage 9, which also runs on wheels within the girders 5. Upon this carriage are supported the electromotors for performing the reciprocation of the charger 16 supported on trunnions 14, its tilting, and its rotation when in the furnace to discharge the contents of the charge boxes. The boxes are picked up from a truck 20, a flange on the charging-bar engaging a corresponding groove on the box. When in this position, a rod passing through the charger secures tha two together, the rod being withdrawn when the box is deposited. To arrive in a position for picking up and dropping the boxes, the rear end of the charger is tilted by cranks 33 and their connections. Suitable electric connections and switches are provided for the motors.
Patent GB-189700385-A (GB)
Title: Improvements in or relating to Pneumatic Tyres.
Inventor: WYNNE FRANK
Filed: 1897-01-06
Granted: 1898-01-06
Abstract: 385. Wynne, F. Jan. 6. Tyres, pneumatic.-Relates chiefly to inflatable sphincter tubes for attaching tyres to rims. The sphincter tube 1 has its ends 1<a> butt jointed by means of plain or corrugated tube 2 to which the inflating-tube is attached, and is then partly inflated and wound spirally with sewing or pack thread 4 in order to prevent radial distension but to allow the tube to extend freely axially. This sewing 4 is applied to the solutioned exterior of the tube, and may be coated with a layer 5 of rubber. Collapsable mandrels may also be used for winding the tubes, and auxiliary sphincter rings may be applied to the inside or outside of the tube 1 in the form of spiral or corrugated metal bands. Such sphincter tubes as described may be applied inflated to a "tubeless" tyre as shown in Fig. 15, and on deflation these contract and bind the edges 9<a>, 9<b> of the cover firmly to the rim 12. Modifications are also described in which the tube 1 may be applied inside ordinary inner tubes or between the inner tubes and the covers. In some cases the air chamber may be formed of a layer of rubber rolled round to form a tube with overlapping edges, a sphincter tube being used to make an airtight joint and to press the extensions of the cover into corresponding recesses in the rim.
Patent GB-189704762-A (GB)
Title: Improved Apparatus for Reducing the Pressure of Liquids and Gases.
Inventor: MATCHETT RICHARD
Filed: 1897-02-22
Granted: 1897-05-01
Abstract: 4762. Matchett, R. Feb. 22. Regulators.-These are chiefly applicable to aÙrating liquids. A diaphragm K, preferably of red rubber, is balanced between springs H and M which can be adjusted so as to deliver fluid at any required pressure. Beneath the diaphragm is a spindle which operates a lever N, one of the arms of which carries a pad or valve P governing the inlet R. The diaphragm K is held in place by the cover F of the casing. The apparatus includes a pressure gauge, and also a relief valve E.
Patent GB-189704870-A (GB)
Title: Improvements in Devices for Automatically Regulating the Quality of Gas.
Inventor: FROST EDWARD JAMES
Filed: 1897-02-23
Granted: 1897-07-03
Abstract: 4870. Frost, E. J., and Middleditch, B. Feb. 23. Mixing air and gases.-For the purpose of automatically regulating the quality of the gas produced by treating air with liquid hydrocarbons, the gas is admitted through a pipe 18 into a chamber 1 containing a float 3 suspended from a counterweighted lever 6 and actuating a valve 16 which controls a supply of air admitted through a pipe 17. The counterweight 9 is carried by a sliding block 11 capable of being adjusted by a screw 13 which is actuated by a key 23. Deflectors 19 and 20 are arranged near the bottom and top of the mixing-chamber.
Patent GB-189706221-A (GB)
Title: Multitubular Sanitary Lamp for Street Lighting and Destroying Sewer and other Noxious Gases.
Inventor: GIBBON JOHN GEORGE
Filed: 1897-03-09
Granted: 1897-08-28
Abstract: 6221. Gibbon, J. G. March 9. Corpses and bodies, treatment and disposal of.- Relates to street and like lamps, adapted for ventilating hospitals, mortuaries, and other buildings. That portion of the foul gas supplied to the combustion chamber A which is not consumed by the flame passes through perforations in the metallic reflector R to a second chamber B, which is raised to a sufficiently-high temperature to destroy microbes and germ life. The air then passes round the edges of the plate S to a third chamber C, whence it escapes through the perforated cap D. The heat of the chamber B may be increased by covering some of the flue tubes F with caps to check the draught. A double wire pauze placed in the bottom of the lantern will grevent explosions should inflammable gases pass through the lamp.
Patent GB-189706291-A (GB)
Title: Improvements in and relating to Self-propelled Vehicles.
Inventor: HIGGINS EDWARD SMITH
Filed: 1897-03-10
Granted: 1898-02-19
Abstract: 6291. Higgins, E. S., Bessemer, H. A., and Nicholson, W. B. March 10. Motor road vehicles.-The chief object is to carry the motor and its appurtenances on a frame independent of the vehicle body. In Fig. 2 the rear part of the vehicle is shown. The motor &c. are carried on the frame A, which is supported by springs on the axles, and which has a jack F at each of its four corners for raising the body when necessary. The body is carried on the axles or on the frame A by springs, the upper and lower parts of which can be easily disengaged. The condenser G, where one is used, is secured to the front, and pivoted to the rear axle, with its front end higher than its rear. The oscillation of the condenser, when the vehicle is in motion, promotes vertical air currents between its tubes. By means of the body and the condenser the motor &c. are entirely closed in. The standard H carries the various handles for steering, controlling, &c., and in its upper part any gauges or indicators required.
Patent GB-189708782-A (GB)
Title: Improvements in Car-couplers.
Inventor: CARROLL AARON HENRY
Filed: 1897-04-06
Granted: 1897-10-02
Abstract: 8782. Carroll, A. H. April 6. Couplings automatic.-Fig. 1 shows view of the entire apparatus uncoupled, Fig. 2 a horizontal section with the device coupled, and Fig. 2<a> a similar view with the device uncoupled. The locking- jaw 9 is pivoted by the pin 6 to the draw-head 1, and has a vertical movement on the pin such that when the jaw is in the coupled position it is at its highest point, and upon being released its under side runs down the curved surface 29, throwing the jaw outwards as it descends to its lowest point. The jaw is retained in the locked position by a block 15 which swings on a vertical pin 14 and has also a vertical movement thereon, being raised and lowered by a rod 31 pivoted. thereto and provided with a tooth 36 for engaging the draw-head when the block is in its lowest position, thus locking the jaw 9 in the coupled position. To uncouple two vehicles, the rod 39 is rotated, whereupon the rod 31 is first swung aside to release its tooth 36, and then it is raised, bringing up the block 15 and releasing the jaw 9, which thereupon swings outwards.
Patent GB-189716559-A (GB)
Title: Mould for Making Prismatic Window Lights and the like.
Inventor: EWEN JOHN MEIGGS
Filed: 1897-07-13
Granted: 1897-10-23
Abstract: 16,559. Ewen, J. M. July 13. Moulding. - Prismatic window lights &c. are formed in a mould A having a removable circular mould bottom B, which can be turned so as to vary the angle which the projecting ribs make with the sides of the hexagonal or other shaped mould. Fig. 5 shows a prism light as formed in the mould.
Patent GB-189730921-A (GB)
Title: Improvements in Cyclometers.
Filed: 1897-12-31
Granted: 1898-08-27
Abstract: 30,921. Lake, H. H., [New Departure Bell Co.]. Dec. 31. Odometers.-The instrument is mounted by sliding its foot a into the clamp bracket P and tightening the screw 0 when the star-wheel A<1> is in position to be engaged by a tappet on the spokes. The fixed framing consists of a cylinder A with transparent lining J and screwed-in ends C, C<1> and a central block K, cut away where necessary and secured by a chambered nut L with dustexcluding packing M. The spindle B of the starwheel carries at its end a pinion D, accidental movement of these parts being prevented by a flat spring k. The pinion D gears with a walking pinion E which, in turn, gears with a fixed internally-toothed ring F and the internal teeth g<2> of the first registering-ring G, Fig. 7 and 8. There is a difference of one between the number of teeth in the rings F and G, so that the latter receives a slow progressive movement. To ' carry' to the rings G, G, G of higher denomination, a series of pinions I, formed as shown in Fig. 9, are mounted on a spindle H and each gears with two consecutive rings. Normally, the hub of the pinion I, where the teeth i<1> are cut away, rests on the smooth part of the ring G and is locked, but when the teeth g<3>, g<4> come round, the former, striking one of the cut-away teeth i<1>, causes the pinion partially to rotate and turns the next ring G one unit, the tooth i dropping into the depression between the teeth.
Patent GB-189804809-A (GB)
Title: Improvements in Gas-making Apparatus.
Inventor: LAMPLOUGH FREDERICK
Filed: 1898-02-26
Granted: 1899-01-07
Abstract: 4809. Lamplough, F. Feb. 26. Gas holders.-An illuminating-gas is obtained by forcing air through gasoline or other light hydrocarbon and storing the product in a holder provided with a pressure-reducing valve. Fig. 1 shows a sectional elevation of the apparatus, in which a pump c with non-return valves is connected by a pipe d with the lower end of a gasoline &c. reservoir a. The reservoir a, provided with a level a<1> and pressure gauge a<2>, is connected at a<3> with the holder b. The holder b is provided with a regulator f<8> controlling the supply of gas through the valve f<3> to the exit pipe f<9>. The pump has a pressure valve in the piston for allowing the escape of air when the maximum pressure is reached, and a screw valve e is provided for cutting off the pump c from the tube d. The pump may be driven by a water motor, the supply of water being regulated by the gas pressure in the holder.
Patent GB-189806417-A (GB)
Title: Improvements in Bearing Blocks for the Rollers of Mangles and other Manual and other Machines.
Inventor: HEAD WILLIAM JOSEPH
Filed: 1898-03-16
Granted: 1898-11-26
Abstract: 6417. Head, W. J., [trading as East London Machine Co.]. March 16. Mangling and wringing machines.-The bearings for the rollers are divided into parts A, B between which springs F are interposed.
Patent GB-189808730-A (GB)
Title: Improvements in or relating to Apparatus for making Medicinal Wafers or Capsules.
Inventor: MORSTADT KARL
Filed: 1898-04-14
Granted: 1898-06-11
Abstract: 8730. Morstadt, K. April 14. Capsules.-An apparatus for making capsules enclosing powdered medicaments &c. consists of three hinged plates A, B, and D, of which A is provided with circular recesses for receiving the lower halves of the capsules, while B is formed with flanged openings for receiving the upper halves. By means of a separate plate the rims of the upper halves of the capsules are bent over as shown. After filling the lower halves and moistening the edges of the upper halves, the plate B is folded over as shown. Finally, the plate B is folded back and the plate D, which is formed with openings similar in size to the capsules, is folded over so as to flatten the rims.
Patent GB-189811977-A (GB)
Title: Improvements in the Method of and Machinery for Making Firelighter Grids.
Inventor: SUTCLIFFE BOOTH
Filed: 1898-05-26
Granted: 1899-04-15
Abstract: 11,977. Sutcliffe, B. May 26. Sawing.-A machine for cutting two or more longitudinal slots in blocks of wood to be used, after dipping, as framework firelighters, is shown in front elevation in Fig. 1. Saws H are mounted in inclined positions upon a shaft J, which is driven by belt gearing X, X<1>, X<2>. During the sawing operations the blocks D are supported by movable tables E, and are depressed towards the saws by adjustable grids K attached to vertical slides F ; these slides are actuated by means of discs N, which are mounted upon a shaft M and provided with rollers P, engaging with grooves in the slide. After every sawing operation, the slides F are raised by means of weights R<2> connected to the slides by cords R, which pass over pulleys R', and the tables E are similarly raised by weights E<3>, connected to the tables by cords E<2>, which pass over pulleys E'. The wooden blocks are fed periodically from hoppers C, to the tables E, by pushers W<2> actuated by bent levers W<1>, cranks W, and rods V<1>, which carry arms V, operated by tappets U, on the shaft M. The feed-mechanism of one or both cutting- mechanisms may be thrown out of action by the use of clutches Z<1> and hand-levers Z. The machine may be used for forming slots or mortises in wood.
Patent GB-189815569-A (GB)
Title: Improvements in Processes for Extracting Caoutchouc.
Inventor: ZURCHER OTTO
Filed: 1898-07-15
Granted: 1898-10-08
Abstract: 15,569. Z³rcher, O. July 15. Preparing flour from bananas &c.-Bananas and the fruit of other Musa plants are cleaned with a water jet, and then cut from the stems, when about half ripe. They are then cut cross-wise, and the surrounding leaves, skin, and stem are separated. The inner portions are drained of liquid, and afterwards extracted by placing them radially in a centrifugal machine, or with turpentine or other solvent in a vacuum or otherwise, for the production of india-rubber. The residue from the inner portions may be dried and ground, to produce a flour.
Patent GB-189825304-A (GB)
Title: Improvements in the Process of Manufacturing Artificial Stone.
Inventor: HADDAN REGINALD
Filed: 1898-11-30
Granted: 1899-11-25
Abstract: 25,304. Haddan, R., [Koepp & Co., R.]. Nov. 30. Stone, artificial ; casting.-In the manufacture of artificial stone by casting cement in moulds, a large proportion of the water is removed by suction before the mass has set, so as to enable the cement particles to expand freely in the act of setting. The suction is effected through apertures in the mould, case, &c. by the use of a vacuum of 40 to 50 cm. produced by an air pump or by water or steam jets, or by using a porous base to the mould consisting of gypsum, tufaceous stone, sponge, porous carbon, &c. covered with a fine mesh web.
Patent GB-189905207-A (GB)
Title: An Improved Belt and Fastener for the same.
Inventor: MILLS BENJAMIN JOSEPH BARNARD
Filed: 1899-03-09
Granted: 1900-01-13
Abstract: 5207. Mills, B. J. B., [Gisclon, J.]. March 9. Belts and bands; belt and band fastenings.-Relates to a woven belt the resisting part of which is composed of metallic wires or cords introduced during the wearing operation. The ends of the belt are coupled by a pair of grooved or corrugated clamps bolted together.
Patent GB-189906151-A (GB)
Title: Improvements in and Combination of Machinery for Shelling the Locust Bean Kernels.
Inventor: CASTLE PETER CAMERON DOUGLAS
Filed: 1899-03-21
Granted: 1900-02-17
Abstract: 6151. Castle, P. C. D. March 21. Drawings to Specification. Disc mills are employed in a process for shelling the kernals of locust beans. The kernels are first split in any ordinary disintegrating-machine, and are then graded and treated in a stone mill, the stones of which are specially dressed. The kernels are subsequently treated in decorticating-machines of an ordinary type.
Patent GB-189918513-A (GB)
Title: Improvements in or relating to Gas Cooking and other similar Stoves.
Filed: 1899-09-13
Granted: 1900-09-08
Abstract: 18,513. Lisle, H., and Presto Gear Case and Components Co. Sept. 13. Gas stoves; hot-closets; waste heat, utilizing.-A cupboard or hot-closet C is mounted upon the hotplate A of a gas cooking or similar stove. The lower part of the closet is sufficiently high to give space for the manipulation of the cooking-utensils, and above this space is a shelf or partition C<1>. A door C<3> closes this lower space, and a door C' closes the upper part of the closet. In this upper portion, shelves C<4>, C<5> are placed for the reception of articles to be warmed or kept hot. The bottom C<6> is removable, as also are the shelves C', C', C<5>, which may be replaced by a rack. The closet is constructed of metal, and may be lined or coated with wood or other non-conducting material. Rails &c. D are provided on the sides of the closet for supporting clothes &c. in order to warm or dry them. The closet is heated by the burner B, and the waste gases from the stove may also be led into the closet.
Patent GB-189923031-A (GB)
Title: Improvements in or relating to the Circulation of Water through the Tuyeres of Blast Furnaces.
Inventor: FOSTER WILLIAM JAMES
Filed: 1899-11-18
Granted: 1900-04-14
Abstract: 23,031. Foster, W. J. Nov. 18. TuyÞres.-The coils of tubular watertuyÞres c and their cooling-coils d are supplied with water, which is drawn through them from a cistern f by means of a pump o, a siphon, or other equivalent means. When the water supply is so arranged that the water flows to the tuyeres without being lifted to the tuyÞre level, valves may be fitted to the supply pipes, to automatically close immediately air is admitted to the interior of the coils through a hole or holes burnt through them.
Patent GB-190005366-A (GB)
Title: Improvements relating to Incandescence Bodies or Media for Gas Lighting.
Inventor: KNOEFLER OSKAR
Filed: 1900-03-21
Granted: 1901-03-21
Abstract: 5366. Kn÷fler, O. March 21. Incandescent gas &c. lamps.-Relates to the manufacture of mantles. Fine threads of combustible material, impregnated or incorporated with thoria and ceria in the proportions of about 93 to 7, are united with a thread or threads similarly treated with pure thoria, and knitted or otherwise formed into mantles. The less fusible threads of pure thoria, being in mechanical juxtaposition to the more fusible threads of thoria and ceria, prevent the latter threads from changing their position, thus maintaining the constancy of the illuminating power and the steadiness of the flame. If preferred, the threads for manufacturing the mantles may be produced by the process described in Specification No. 11,038, A.D. 1895.
Patent GB-190011003-A (GB)
Title: Improvements in Electric Railways on the Third Rail or Surface Contact Systems.
Filed: 1900-06-16
Granted: 1900-12-22
Abstract: 11,003. Lake, H. H., [McElroy-Grunow Electric Railway System]. June 16. Electric railways on the sectional conductor or third rail system. Conductors; switches.-The third rail is composed of insulated sections 3, 4, placed alternately on opposite sides, the power-supplying section 4 being shorter and being overlapped at both ends by the sections 3, through which a shunt current is sent to throw the switches by way of the leads 2, resistances r, and magnet coils. The power sections 4 are connected to the fixed armatures a, and the circuit is completed by lifting the magnets m, which are connected by flexible connections s to the feeder f. An additional switch e in each box is connected to the feeder, and can be brought by hand into contact with the armature a, to supply an exciting current in case the main circuit has been interrupted. Or, in a modification, the circuit is restored by current from a portable battery sent through an insulated stud connected through the magnet coils to the return t. The construction of the switch and box is shown by two sections at right-angles to each other in Figs. 11 and 13. The feeders f are carried in by plugs j filled with insulating-material, and the lid is similarly made tight with a flange v. The fixed armatures a are attached to the cross-piece u, from which the magnets are suspended and guided by an insulated bolt 33 connected to the feeder by a clamp 37, and to the magnet cores by flexible connections s. The wire 6 is also connected to this bolt 33, and through a fuse to the arm z, which can be turned against the action.of a spring 29 into contact with posts 30 on the armatures a by means of the head e on its axis. The sectional conductors 3, 4 consist of L-shaped bars held apart by insulating-material 12<I> in the H-section insulators 10 resting on the sleepers &c., and are prevented from touching the tie-bars by distance-pieces 11. Collectors.-A pair of shoes b, with inclined ribs on their working faces, are pivoted at 21 to the sliding shanks 17, which are pressed down in their guides by the floating lever 8 held by a spring 19 attached to the frame, which consists of a pair of side bars connected by end pieces 13 for attachment under the vehicle.