Patent SG-11201907931W-A (SG)
Title: Drug-polymer conjugate
Inventor: BIRKETT STEPHEN
IPC: A61P27/02
Filed: 2018-03-14
Abstract: 30 35 40 10 15 20 25 Time [Weeks] —0— Example 66 —0— Example 63 12 8 4 Mean p up i l diame ter [mm ] (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIP0 I PCT omit VIII °nolo VIII woo IIV loo 11011111° oimIE (10) International Publication Number WO 2018/165710 Al (51) International Patent Classification: A61K 31/5575 (2006.01) A61P 27/02 (2006.01) A61K 47/50 (2017.01) (21) International Application Number: PCT/AU2018/050233 (22) International Filing Date: 14 March 2018 (14.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 2017900888 14 March 2017 (14.03.2017) AU 15/458,546 14 March 2017 (14.03.2017) US (71) Applicant: POLYACTIVA PTY LTD [AU/AU]; Level 9, 278 Collins Street, Melbourne, Victoria 3000 (AU). (72) Inventors: BIRKETT, Stephen, Lonsdale; 11 Langewan Road, Langwarrin, Victoria 3910 (AU). DONOHUE, An- drew, Craig; 15 Birdwood Street, Bentleigh East, Victo- ria 3165 (AU). D'SOUZA, Asha, Marina; 53 Shepparson Avenue, Carnegie, Victoria 3163 (AU). NG, Sara Man Yee; 4/35 Clift Street, Mt Stuart, Tasmania 7000 (AU). SULISTIO, Adrian; 1/17-19 Peate Avenue, Glen Iris, Vic- toria 3146 (AU). TAIT, Russell, John; 33 Campbell Road, Balwyn, Victoria 3103 (AU). VALADE, David; 1A Stel- la Street, Glenroy, Victoria 3046 (AU). NAYLOR, Alan; 1 Limekiln Close, Royston, Hertfordshire SG8 9XP (GB). WATLING, Jason; 6 Seville Court, Cheltenham, Victoria 3192 (AU). (74) Agent: PHILLIPS ORMONDE FITZPATRICK; Level 16, 333 Collins Street, Melbourne, Victoria 3000 (AU). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (54) Title: DRUG-POLYMER CONJUGATE —T—Q—R—Q—T— ,0 0 L (R)' (D) D (I) 0 R 5 Figure 6 (57) : A polymer-prostaglandin conjugate comprising: a polymer backbone comprising a plurality of moieties of formula (I): where: T represents a triazole moiety; Q is independently selected at each occurrence and may be present or absent and when present represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon; D is selected from prostaglandins; and L is a group of formula (II) wherein R 5 is selected from hydrogen and C1 to C6 alkyl; (R) indicates the end of the group bonded to the R group; and (D) indicates the end of the group attached to the group D. [Continued on next page] WO 2018/165710 Al OII OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))