baber/WOPTO huggingface dataset:
Patent WO-2021041607-A1 (WO)
Title: Dispositif et procédé pour évaluer un échantillon de fluide sur un consommable à multiples substances à analyser à usage unique
Inventor: SAMPRONI JENNIFER
IPC: G01N35/00
Filed: 2020-08-27
Abstract: L'invention concerne des consommables de diagnostic à usage unique destinés à être utilisés dans la réalisation de multiples analyses sur un échantillon de fluide. Les consommables de diagnostic comprennent une première région de détection conçue pour l'analyse d'au moins une substance à analyser dans un échantillon de fluide qui a été reçu par le consommable de diagnostic. Le consommable de diagnostic comprend en outre un matériau de transport de fluide conçu pour faire circuler une partie de l'échantillon de fluide dans une seconde région de détection reliée fluidiquement au matériau de transport de fluide et conçue pour effectuer une seconde analyse de l'échantillon de fluide. L'invention concerne également des procédés pour effectuer de multiples analyses d'un échantillon de fluide sur un consommable de diagnostic à usage unique.
Patent WO-2021046222-A1 (WO)
Title: Adaptive control of electricity consumption
Inventor: CHOQUET PASCAL
IPC: H02H3/42
Filed: 2020-09-03
Abstract: A method for controlling a process that draws power from an electrical power source operates by obtaining time-related electrical demand data from the electrical power source and adaptively adjusting at least one control parameter in a control algorithm for the process to reduce the cost of the electrical energy consumed. The time-related electrical demand data indicates at least diurnal variation, and optionally seasonal variation, in electrical power demand. The time-related electrical power demand data may also include real-time electrical power demand data from the electrical power source.
Patent WO-2021062189-A1 (WO)
Inventor: MAKAROV VADIM
IPC: A61K31/4245
Filed: 2020-09-25
Abstract: L'invention concerne des dérivés d'isoxazole-3-carboxamide et leur utilisation dans le traitement d'infections et de maladies virales, telles que des maladies provoquées par des virus de la famille Picornaviridae des virus (par exemple, des rhinovirus, des entérovirus et des virus coxsackie). Les dérivés ont une bonne efficacité contre une gamme de virus, y compris des souches virales résistantes au pléconaril, et ont une faible induction du cytochrome P4503A4 (CYP3A4).
Patent WO-2021076977-A1 (WO)
Title: Methods for modulating human l1 retrotransposons rna and compositions for use therein
Inventor: ORLANDO VALERIO
IPC: C12N15/85
Filed: 2020-10-16
Abstract: Compositions and methods for upregulating L1 RNA activity in a subject in need thereof are provided. The compositions include nucleic acids encoding L1 RNA or the L1 RNA, alone, or contained in an expression vector and/or further contained within osteogenic progenitor cells, for example, mesenchymal stem cells, genetically engineering to express L1 RNA. In this aspect, the compositions are used to increase L1 RNA levels for example, L1 RNA copy number in subjects in need of increasing their bone mass index. In a preferred embodiment, the bone progenitor cells are autologous cells. Compositions and methods for downregulating L1 RNA levels/activity in a subject in need thereof are also provided. The compositions include one or more agents in effective amounts to knockdown L1 RNA in a cell. The compositions can be used to treat conditions associated with ageing. A preferred agent is a L1 RNA antisense oligonucleotide.
Patent WO-2021126361-A1 (WO)
Inventor: JAWORSKI BRADLEY S
IPC: H01R9/24
Filed: 2020-10-20
Abstract: La présente invention concerne des systèmes et un procédé destiné à un bornier qui peut comprendre un bloc isolant composé d'un matériau électriquement isolant. La structure isolante peut avoir un premier trou d'interconnexion s'étendant entre une première et une deuxième ouverture dans le bloc isolant. Un second trou d'interconnexion peut s'étendre entre une troisième et une quatrième ouverture dans le bloc isolant. Une distance entre les première et deuxième ouvertures peut être inférieure à une distance entre les troisième et quatrième ouvertures. Un premier élément électroconducteur peut s'étendre entre les première et deuxième ouvertures. Un second élément électroconducteur peut s'étendre entre les troisième et quatrième ouvertures. Les premier et second éléments électroconducteurs peuvent être séparés les uns des autres par une partie du bloc isolant.
Patent WO-2021086950-A1 (WO)
Inventor: KHADIVI BAHRAM
IPC: A61M25/01
Filed: 2020-10-28
Abstract: Systems and methods for positioning a transcatheter aortic valve are disclosed. A system can include a first catheter, a second catheter, and a flexible wire all independently movable with respect to each other, and configured to be implanted in respective aortic valve cusps in order to accurately determine a real-time coplanar angle of the nadirs of each of the first aortic valve cusp, the second aortic valve cusp, and the third aortic valve cusp, thereby determining a desired valve implantation depth.
Patent WO-2021087145-A1 (WO)
Inventor: PASCA SERGIU P
IPC: A61K35/30
Filed: 2020-10-29
Abstract: Human striatal and midbrain organoids or spheroids are generated in vitro, which may be generated at least in part from human pluripotent stem (hPS) cells. Such spheroids model the regions of the human brain and comprise specific sets of cells that are associated with the striatum, including mature medium spiny neurons, and midbrain of a human, and that can be subsequently assembled with the cortex to form cortico-striatal-midbrain circuits in vitro.
Patent WO-2021137960-A1 (WO)
Title: Protecting commercial off-the-shelf program binaries from piracy using hardware enclaves
Inventor: GE XINYANG
IPC: G06F21/54
Filed: 2020-11-17
Abstract: This disclosure describes systems and methods for protecting commercial off-the-shelf software program code from piracy. A software program may include multiple image files having code and data. A platform may modify the executable file such that the data may be placed at a location in memory that is an arbitrary distance from the code. The platform may encrypt the code and provide it to a computing device comprising a hardware enclave. The computing device may load the encrypted code into the hardware enclave but load the data into memory outside the hardware enclave. The computing device may request a decryption key from an authentication server using a hash of the hardware enclave signed by a processor. The authentication server may provide the decryption key if it verifies the signature and the hash. The computing device may decrypt the code and mark the hardware enclave as non-readable.
Patent WO-2021102215-A1 (WO)
Title: Procédés et compositions pour augmenter l'efficacité de transduction avec des protéines de fusion de membrane cellulaire
Inventor: LI CHENGWEN
IPC: C07K14/47
Filed: 2020-11-20
Abstract: L'invention concerne des procédés et des compositions pour augmenter l'efficacité de l'introduction (par exemple, de la transduction). En particulier, l'invention concerne des procédés d'augmentation de l'efficacité de l'introduction (par exemple, la transduction) par mise en contact d'une cellule hôte avec un agent hétérologue en présence d'une protéine de fusion de membrane cellulaire ou d'un fragment fonctionnel ou d'un dérivé de celle-ci. L'invention concerne en outre des compositions qui comprennent un agent hétérologue et une protéine de fusion de membrane cellulaire ou un fragment fonctionnel ou un dérivé de celle-ci.
Patent WO-2021108526-A1 (WO)
Inventor: BHARADWAJ RAJIV
IPC: B01L3/02
Filed: 2020-11-25
Abstract: Devices, systems, and their methods of use, for generating droplets are provided. The devices, systems, and methods may include transporting a first liquid through an outlet of a channel and causing relative motion of the outlet and an interface of a second liquid to produce droplets of the first liquid in the second liquid. The devices, systems, and methods may also include illuminating a portion of the liquid as the liquid exits from an outlet. The invention also provides methods, devices, and systems for changing the size of a droplet and for eliminating a droplet from a plurality of droplets.
Patent WO-2021145968-A1 (WO)
Title: Methods for valorization of lignin-rich solids from anaerobic digestate
Inventor: CASAD ROBERT C
IPC: C12P7/64
Filed: 2020-12-02
Abstract: A liquid suspension of lignin-rich microparticles can be recovered from anaerobic digestion of ruminant animal manure. This has similar particle size distribution to that obtained from anaerobic digestion of steam pretreated lignocellulosic feedstocks. This demonstrates that similar lignin-rich microparticles can also be formed biologically, in the absence of thermal treatment that melts lignin. As a consequence, given a sufficiently complete digestion, lignin-rich microparticles will be formed during anaerobic digestion of ruminant manure and of lignocellulosic feedstocks that have never been steam pretreated to temperatures above the lignin melting point. Methods for recovering and valorizing this lignin are disclosed.
Patent WO-2021126777-A1 (WO)
Title: Cache management based on access type priority
Inventor: YIN JIEMING
IPC: G06F12/126
Filed: 2020-12-14
Abstract: Systems, apparatuses, and methods for cache management based on access type priority are disclosed. A system includes at least a processor and a cache. During a program execution phase, certain access types are more likely to cause demand hits in the cache than others. Demand hits are load and store hits to the cache. A run-time profiling mechanism is employed to find which access types are more likely to cause demand hits. Based on the profiling results, the cache lines that will likely be accessed in the future are retained based on their most recent access type. The goal is to increase demand hits and thereby improve system performance. An efficient cache replacement policy can potentially reduce redundant data movement, thereby improving system performance and reducing energy consumption.
Patent WO-2021133660-A1 (WO)
Inventor: DENKER ANDREW
IPC: A61P7/04
Filed: 2020-12-18
Abstract: Provided are methods for clinical treatment of pregnancy-associated atypical haemolytic uraemic syndrome (p-aHUS), including postpartum aHUS, using an anti-C5 antibody, or antigen binding fragment thereof, such as ravulizumab (ULTOMIRIS®).
Patent WO-2021138644-A1 (WO)
Title: Heaters and their use in temperature gradient and traveling wave chromatography
Inventor: TOLLEY SAMUEL
IPC: G01N30/30
Filed: 2021-01-02
Abstract: Certain configurations are described of column heaters that can be used in gas chromatography applications to provide individual heating zones along a gas chromatography column (550). The column heater may comprise a plurality of inductive elements (510-530) that can be used to provide heating zones. A thermally conductive support can be used with the gas chromatography column and the inductive elements if desired. The column heater can be used to provide a travelling wave, a thermal gradient or other heating profiles.
Patent WO-2021138656-A1 (WO)
Title: Machine side connection for fume extraction torches
Inventor: BINZEL OLIVER
IPC: B23K9/32
Filed: 2021-01-04
Abstract: Provided for herein is an apparatus that includes a machine-side connection housing. The machine-side connection housing includes a machine-side connection configured to provide a welding consumable or an electrical connection to a welding/cutting torch head. The apparatus also includes a fume extraction connection housing that includes a fume extraction connection to a fume extraction device. A flexible connection is arranged between the machine-side connection housing and the fume extraction connection housing. A seal that includes a first orifice is arranged between the fume extraction connection and the machine-side connection. Finally, a conduit, configured to connect the machine-side connection to the welding/cutting torch head, is arranged to pass through the first orifice, through the flexible connection and through the fume extraction connection housing to the welding/cutting torch head.
Patent WO-2021138696-A1 (WO)
Title: System and method for acoustic detection of emergency sirens
Inventor: BUCK MARKUS
IPC: G05D1/00
Filed: 2021-01-05
Abstract: A method detects presence of a multi-tone siren type in an acoustic signal. The multi-tone siren type is associated with one or more siren patterns, where each siren pattern includes a number of time patterns at corresponding frequencies. The method includes processing a number of frequency components of a frequency domain representation of the acoustic signal over time to determine a corresponding plurality of values. That processing includes determining, for each frequency component, a value characterizing a presence of a time pattern associated with at least one siren pattern. The method also includes processing the values according to the siren patterns to determine a detection result indicating whether the multi-tone siren type is present in the acoustic signal.
Patent WO-2021142447-A1 (WO)
Inventor: OZSOLAK FATIH
IPC: A61K48/00
Filed: 2021-01-11
Abstract: L'invention concerne des vecteurs de thérapie génique, tels que des vecteurs ve virus adéno-associés (VAA), qui co-expriment au moins deux GDI. Les vecteurs selon l'invention peuvent être largement utilisés pour traiter un certain nombre de troubles génétiques tels que des troubles d'expansion de répétitions de trinucléotides.
Patent WO-2021163327-A1 (WO)
Title: Compositions and methods for treating and/or preventing ocular disorders
Inventor: AMBATI JAYAKRISHNA
IPC: A61K31/4178
Filed: 2021-02-11
Abstract: Provided are methods for treating macular degeneration, optionally macular degeneration, in subject in need thereof. In some embodiments, the methods include administering to a subject in need thereof a therapeutically effective amount of fluoxetine in an amount and via a route sufficient to treat or prevent development of macular degeneration in the subjects. Also provided are methods for inhibiting activation of an NLRP3-ASC inflammasome in the subjects, inhibiting ASC speck formation in the subjects, inhibiting Alu RNA-induced RPE degeneration in the subjects, and treatment and/or prevention of the development of diseases, disorders, and/or conditions.
Patent WO-2022182332-A1 (WO)
Inventor: MIFTAKHOV VALERY
IPC: H02J1/10
Filed: 2021-02-23
Abstract: A power generating system includes a hydrogen fuel cell and rechargeable battery connected together in series to be used as a load following system without the use of a DC-DC converter. The hydrogen fuel cell's cathode air compressor is driven off of the output of this power generation system. The system is wired in series with the use of switches and bypass diodes and limits the system output voltage so that the maximum voltage of downstream components is not exceeded. The system further includes an isolated DC-DC converter to charge the rechargeable battery with the hydrogen fuel cell.
Patent WO-2021173968-A1 (WO)
Inventor: KUMTA PRASHANT N
IPC: B23K26/342
Filed: 2021-02-26
Abstract: The invention relates to a device and method for preparing a structure or object using an additive manufacturing process referred to as sequential cold spray laser sintering. The method includes depositing by cold spraying a plurality of sequential layers of material onto a substrate/build plate or particles of materials onto a compacted powder bed of material and employing an energy source to sinter or melt each of the plurality of sequential layers or powders to produce sequential sintered layers, wherein the number of additional layers is determined based on those needed to produce the final structure.
Patent WO-2021178449-A1 (WO)
Title: Compositions et méthodes pour le traitement du cancer du pancréas
Inventor: LIM KIAN-HUAT
IPC: A61K48/00
Filed: 2021-03-02
Abstract: La présente invention concerne une méthode de traitement du cancer du pancréas comprenant l'administration d'une quantité efficace d'un agent inhibiteur de MK2. Dans d'autres aspects, le procédé peut comprendre l'administration de la quantité efficace de l'agent inhibiteur de MK2 en combinaison avec une composition de chimiothérapie. Dans d'autres aspects, l'invention concerne une composition pour le traitement du cancer du pancréas qui comprend une quantité efficace d'un agent inhibiteur de MK2 et une quantité efficace d'une composition de chimiothérapie.
Patent WO-2021194945-A1 (WO)
Inventor: FINISON JEREMY
IPC: A47L11/30
Filed: 2021-03-22
Abstract: A floor cleaning system may include a docking station to which an autonomous floor cleaning machine can dock between cleaning operations. The docking station can provide power to the autonomous floor cleaning machine to recharge the batteries of the machine when not in use. The docking station may also supply fresh cleaning fluid to the floor cleaning machine and remove collected waste from the machine. In practice, the floor cleaning machine may itself become dirty over repeated use, such as when cleaning greasy floor surfaces. Accordingly, the docking station may include flushing orifices to clean the floor cleaning machine itself, such as with a degreasing composition.
Patent WO-2021236235-A1 (WO)
Inventor: KONECKY SOREN
IPC: G01N21/47
Filed: 2021-03-30
Abstract: Premier signal généré avec un premier détecteur de lumière en réponse à un signal ultrasonore rencontrant un premier faisceau de mesure. Un second signal est généré avec un second détecteur de lumière en réponse au signal ultrasonore rencontrant un second faisceau de mesure. Le second faisceau de mesure se propage à travers l'échantillon et le premier faisceau de mesure se propage à l'extérieur de l'échantillon.
Patent WO-2021202624-A1 (WO)
Title: Compositions and related methods for reducing vapor effect of volatile herbicides
Inventor: PENNER DONALD
IPC: A01N37/10
Filed: 2021-03-31
Abstract: The disclosure relates to photosensitizer- and herbicide-containing compositions and related methods for reducing the vapor effect of volatile herbicides and other phytotoxic materials on sensitive, desirable plants. The compositions can include a photosensitizer such as riboflavin and a volatile growth regulator herbicide. The composition can be applied to a target area to control an undesired herbicide-sensitive target plant in the area with the herbicide. The presence of the photosensitizer in the composition reduces the vapor effect of the volatile herbicide or other atmospheric phytoxicant. A reduced vapor effect reduces damage to other desired sensitive plants, whether inside or outside of the target area of application. The compositions are suitably aqueous, for example in a relatively concentrated form for dilution or in a relatively dilute form for spraying.
Patent WO-2021202859-A1 (WO)
Title: Medical therapy systems with closed-loop controls and methods of making and using the same
Inventor: CAUDILL CHARLES
IPC: G16H40/63
Filed: 2021-04-01
Abstract: A closed-loop control for a medical therapeutic system is disclosed that includes one or more processes or components for/in the medical therapeutic system, a controller configured to determine whether one or more operations of the process(es) or component(s) are within a corresponding safety envelope, and one or more sensors. The process(es)/component(s) are configured to deliver a controlled amount of a substance, energy or force to a patient. The sensor(s) are configured to measure or determine a value of a measurable parameter of the process(es)/component(s) and/or effected by the operation(s), and provide the value(s) of the measurable parameter(s) to the controller. The controller determines whether each of the operation(s) are within the corresponding safety envelope according to a corresponding function that mathematically describes the operation. The safety envelope corresponds to known safe values of the measurable parameter, or an unmeasured parameter based on the measurable parameter.
Patent WO-2021207336-A1 (WO)
Inventor: REDDY VENU
IPC: A61K31/4164
Filed: 2021-04-07
Abstract: La présente invention concerne des formulations orales pour une libération prolongée et une rétention gastro-intestinale prolongée, ainsi que des procédés de préparation et des utilisations de celles-ci.
Patent WO-2021231191-A1 (WO)
Inventor: HICKS JACQUELINE D
IPC: C07D401/04
Filed: 2021-05-07
Abstract: La présente invention concerne un composé de Formule (I) et des compositions pharmaceutiques comprenant un ou plusieurs desdits composés, et des procédés d'utilisation desdits composés pour traiter ou prévenir des thromboses, des embolies, une hypercoagulabilité ou des changements fibrotiques. Les composés sont des inhibiteurs sélectifs de l'activation du facteur XI.
Patent WO-2021257247-A1 (WO)
Inventor: KRAKHMAN VLADIMIR
IPC: G01F1/84
Filed: 2021-05-24
Abstract: An example optical measurement system includes: a first light source configured to emit a first light beam; a first optical sensor configured to output first measurements based on detecting the first light beam; a second light source configured to emit a second light beam; a second optical sensor configured to output second measurements based on detecting the second light beam, wherein the first measurements and the second measurements comprise variable components; a third optical sensor configured to output third measurements based on detecting the second light beam or a third light beam, wherein the third measurements comprise a first steady state component; and a compensation circuit configured to control a first light output of the first light beam and a second light output of the second light beam by controlling current to the first light source and the second light source based on the third measurements.
Patent WO-2021247749-A1 (WO)
Inventor: SCANDURA JOSEPH M
IPC: C12N5/0789
Filed: 2021-06-02
Abstract: Methods and compositions are described herein that involve expansion of hematopoietic stem cells and/or hematopoietic progenitor cells.
Patent WO-2022260676-A1 (WO)
Title: Extender compositions and use thereof to increase on-seed adherence and stability of microbes
Inventor: BELCHER RICHARD
IPC: C12N1/04
Filed: 2021-06-10
Abstract: The present disclosure provides extender compositions which prolong or maintain the viability of microbes on-seed, thus increasing the stability and shelf-life of the microbes on coated seed, even when the seed has been pre-treated with other chemicals and/or biologicals (plant enhancing agents). The compositions disclosed herein further promote the adherence of microbes to seed during the seed coating process. The disclosure further teaches seed coating kits, methods of use, and seeds and plant propagating material produced therefrom which are coated with the compositions disclosed herein.
Patent WO-2021257655-A1 (WO)
Title: Actrii-alk4 antagonists and methods of treating heart failure
Inventor: SURAGANI RAJASEKHAR
IPC: C07K14/495
Filed: 2021-06-16
Abstract: In some aspects, the disclosure relates to ActRII-ALK4 antagonists and methods of using ActRII-ALK4 antagonists to treat, prevent, or reduce the progression rate and/or severity of heart failure (HF), particularly treating, preventing or reducing the progression rate and/or severity of one or more HF-associated comorbidities. The disclosure also provides methods of using an ActRII-ALK4 antagonist to treat, prevent, or reduce the progression rate and/or severity of heart failure associated with a variety of conditions including, but not limited to, genetic cardiomyopathies, muscle wasting diseases, and muscular dystrophies.