Patent CA-3086768-A1 (CA)
Inventor: KAPPEL BARRY JAY
IPC: C07K14/475
Filed: 2019-01-03
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY  (PCT) (19) World Intellectual Property                111111 1 11111111 111111 1 11 Organization International Bureau                                (10) International Publication Number (43) International Publication Date                   WO 2019/136125 Al 11 July 2019 (11.07.2019)         WIPO I PCT (51) International Patent Classification: A61K 38/00 (2006.01)     CO7K 14/475 (2006.01)    Published: C07K 14/00 (2006.01)                        ¨ with international search report (Art. 21(3)) ¨                                               before the expiration of the time limit for amending the (21) International Application Number:    claims and to be republished in the event of receipt of PCT/US2019/012148    amendments (Rule 48.2(h)) (22) International Filing Date:    ¨ with sequence listing part of description (Rule 5.2(a)) 03 January 2019 (03.01.2019) (25) Filing Language:                     English (26) Publication Language:                English (30) Priority Data: 62/613,083         03 January 2018 (03.01.2018)    US (71) Applicant: SAPIENCE THERAPEUTICS, INC.  [US/US]; 500 Mamaroneck Avenue, Suite 320, Harrison, NY 10528 (US). (72) Inventors: KAPPEL, Barry, Jay; 500 Mamaroneck Av-enue, Suite 320, Harrison, NY 10528 (US). MERUTKA, Gene; 500 Mamaroneck Avenue, Suite 320, Harrison, NY  10528 (US). ROTOLO, Jimmy, Andrew; 500 Mamaro-neck Avenue, Suite 320, Harrison, NY 10528 (US). = (74) Agent: YVON,Anne-Marie, C.; Grimes &YvonLLP, 800 Third Avenue, 28th Floor, New York, NY 10022 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, ER, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: tin ¨ as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) re) ON (54) Title: ATF5 PEPTEDE VARIANTS AND USES THEREOF 0 (57) Abstract: Provided are ATF5 peptides having a truncated ATF5 leucine zipper region and, optionally, a cell -penetrating region, " compositions comprising the ATF5 peptides, and methods of inhibiting proliferation of and promoting cytotoxicity in a neoplastic cell C using the ATF5 peptides.