Patent SG-11201900021P-A (SG)
Title: Methods and compositions for the treatment of cancer
Inventor: SOUCEK LAURA
IPC: C07K14/82
Filed: 2017-07-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 18 January 2018 (18.01.2018) W I PO I PCT Iiiimmomiolollmonoloommololomiinooluom (10) International Publication Number WO 2018/011433 Al (51) International Patent Classification: CO7K 14/82 (2006.01) (21) International Application Number: PCT/EP2017/067998 (22) International Filing Date: 17 July 2017 (17.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16382339.6 15 July 2016 (15.07.2016) EP (71) Applicants: FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL HE- BRON [ES/ES]; Natzaret, 115, E-08025 Barcelona (ES). FUNDACIO PRIVADA INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS [ES/ES]; Pas- seig Lluis Companys, 23, E-08010 Barcelona (ES). (72) Inventors: SOUCEK, Laura; FUNDACIO PRIVA- DA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL HEBRON, Natzaret, 115, E-08025 Barcelona (ES). JAUSET GONZALEZ, Toni; FUNDACIO PRIVA- DA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL HEBRON, Natzaret, 115, E-08025 Barcelona (ES). BEAULIEU, Marie-Eve; FUNDACIO PRIVADA INSTI- TUT D'INVESTIGACIO ONCOLOGICA DE VALL HE- BRON, Natzaret, 115, E-08025 Barcelona (ES). (74) Agent: VAZQUEZ VAZQUEZ, Irene; ABG PATEN- TES, S.L., Avda. de Burgos, 16D , Edificio EUROMOR, E-28036 Madrid (ES). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) (54) Title: METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER (57) : The invention relates to a polypeptide comprising or consisting of the polypeptide of SEQ ID NO: 1 wherein the residue X at position 89 of SEQ ID NO: 1 is not a cysteine, or a functionally equivalent variant of said polypeptide wherein the residue X at position 89 of SEQ ID NO: 1 is not a cysteine and their use in medicine, particularly in the prevention and/or treatment of cancer.