baber/WOPTO huggingface dataset:
Patent AU-2017271662-A1 (AU)
Title: Drug-delivery nanoparticles and treatments for drug-resistant cancer
Inventor: MEDINA -KAUWE LALI K
IPC: A61P35/00
Filed: 2017-05-26
Abstract: Disclosed herein are compositions comprising nanoparticles comprising a carrier polypeptide and a double-stranded oligonucleotide, wherein the carrier polypeptide comprises a cell-targeting segment, a cell-penetrating segment, and an oligonucleotide-binding segment: and wherein the molar ratio of the carrier polypeptide to the double-stranded oligonucleotide in the nanoparticle composition is less than about 6:1, along with methods of making and using such nanoparticles. Further described are methods of treating a subject with a cancer, such as a chemotherapeutic drug resistant cancer comprising administering to the subject a composition comprising nanoparticles, the nanoparticles comprising a carrier polypeptide comprising a cell-targeting segment, a cell-penetrating segment, and an oligonucleotide-binding segment; a double-stranded oligonucleotide bound to the oligonucleotide-binding segment; and a chemotherapeutic drug bound to the double-stranded oligonucleotide. Also described are pharmaceutical compositions, articles of manufacture, and kits comprising the described nanoparticles.
Patent AU-2017272612-A1 (AU)
Title: Self-propelled module for oversize loads
Inventor: BETTELLA MASSIMO
IPC: B60P3/40
Filed: 2017-05-30
Abstract: A self-propelled module (10) for oversize loads, comprising: – two ground movement assemblies (11, 12) with oil-pressure controlled actuation, – a transverse rocker (13) arranged between the movement assemblies (11, 2), which are coupled thereto independently, – oil-pressure controlled suspension means (14, 15), arranged on corresponding oscillating supports (16, 17) coupled to the transverse rocker (13), – a load-bearing frame (18), supported by the oil-pressure controlled suspension means (14, 15), comprising an oil-pressure controlled circuit adapted to serve the ground movement assemblies (11, 12) and the suspension means (14, 15), – a rotary distribution unit (19), having a vertical axis (X), mounted on the load-bearing frame (18) for supplying the ground movement assemblies (11, 2) and the oil-pressure controlled suspension means (14, 15), a first part (20) of the rotary distribution unit (19) being fixed to the load-bearing frame (18), a second part (21) being free to rotate about the vertical axis (X) with respect to the first part (20), – a resting bed (22), which is supported by a center bearing (23) that is coaxial to the rotary distribution unit (19), – below the resting bed (22) there being means for the relative rotation, about the vertical axis (X), of the resting surface (22) with respect to the load-bearing frame (18).
Patent AU-2017278057-A1 (AU)
Title: Ceramide galactosyltransferase inhibitors for the treatment of disease
Inventor: WANG BING
IPC: A61P25/00
Filed: 2017-06-09
Abstract: Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.
Patent AU-2017285708-A1 (AU)
Title: A freeze prevention valve
Inventor: MORRIS PETER JOHN
IPC: F16K17/38
Filed: 2017-06-16
Abstract: A freeze prevention valve comprising a body having an inlet (14) and an outlet (16) for fluid to exit the valve in an open condition, a valve seat (18) provided adjacent an opening (22) of the valve, a piston member (20) that is movable in the body, the piston member comprising a piston shaft and a piston head (24), the piston head (24) arranged to seat against the valve seat (18) in a closed condition of the valve, a temperature sensing device (26) comprising a temperature sensitive element (28), operatively associated with the piston head (24), wherein the temperature sensitive element contracts and expands when the temperature of the fluid sensed by the temperature sensing device decreases or increases, wherein contraction of the temperature sensitive element allows the return spring (30) to move the piston member to unseat the piston head from the valve seat and thereby open the valve.
Patent AU-2017322804-A1 (AU)
Title: Hydraulic mooring cable holding device, system and method
Inventor: VAN DER BURG GERRIT
IPC: B63B21/00
Filed: 2017-09-07
Abstract: A hydraulic mooring cable holding device provides a hydraulic cylinder-piston combination (20) for controlling the force on a mooring cable between one end of a ship and a mooring point. An overpressure protection part (26) with hydraulic liquid passing from the hydraulic cylinder (20) to a reservoir (260) when the pressure in the cylinder exceeds a threshold value, and returns the hydraulic liquid when the pressure has dropped. An auxiliary reservoir (24) with a steeper pressure response than the main reservoir (260) is connected in parallel with the main reservoir. The auxiliary reservoir may be connected to and/or disconnected from the cylinder under control of a sensor or a further mooring device at the other end of the ship, to reduce movement of the ship e.g. in swell. Furthermore, pressure from the auxiliary reservoir may be used to drive an electric generator.
Patent AU-2017325654-A1 (AU)
Title: Engineered polypeptides and uses thereof
Inventor: VISWANATHAN KARTHIK
IPC: C07K16/10
Filed: 2017-08-02
Abstract: Polypeptides, such as antibody molecules and fusion proteins, comprising an Fc region, are disclosed. The polypeptides can be used to treat, prevent, and/or diagnose disorders. In particular, Fc regions comprising either one or multiple mutations selected from the partcicular mutations disclosed in Table 1 are disclosed. Certain of said mutations result in increased affinity for the neonatal Fc receptor (FcRn), and certain of said mutations result in ehnaced half-life of engineered antibodies and also have an impact on effector functions. Particular disclosed mutations are M252Y, S254T, T256E, L309N, T250Q, M428L, N434S, N434A, T307A, E380A, N434A, M252Y, S254T, T256E, or a combination thereof as e.g. T256D/Q311V/A378V, H285N/ T307Q/N315D, H285D/T307Q/A378V, T307Q/Q311V/A378V, T256D/ N286D/T307R/Q311V/A378V, or T256D/T307R/Q311.
Patent AU-2017328017-A1 (AU)
Title: Phase-noise compensation reference signal configuration reporting and signaling
Inventor: JOHN WILSON MAKESH PRAVIN
IPC: H04L27/00
Filed: 2017-08-14
Abstract: Methods, systems, and devices for wireless communication are described. A user equipment (UE) may report a phase-noise compensation reference signal (PCRS) configuration to a base station to enable per-UE PCRS signaling. For example, a UE may operate in a wireless communications system using carrier frequencies greater than 6 GHz, which may be affected by phase noise. The UE may accordingly determine a PCRS configuration based on a capability to receive signals. The PCRS configuration may include a resource mapping for one or more PCRS, a number of PCRS ports used for PCRS, a multiplexing scheme for one or more PCRS ports, or the UE's phase noise estimation capability. The UE may then transmit a reporting message including the PCRS configuration to a base station. The base station may use the PCRS configuration for PCRS transmissions to the UE.
Patent AU-2017331156-A1 (AU)
Title: Method and system for washing grapes, especially grapes for winemaking
Inventor: TURATTI ANTONIO
IPC: A23N12/02
Filed: 2017-09-15
Abstract: Process and plant for washing of grapes especially for wine making comprising: - a first stage of automated washing able to remove substances and / or foreign bodies from the grapes at least through the effect of chemical agents; - a second stage of automated washing to remove chemical agents from the grape; the phases of washing being such as to preserve the integrity and the organoleptic qualities of the grape.
Patent AU-2017339839-A1 (AU)
Title: Substituted pyrrolidines as CFTR modulators
Inventor: ALTENBACH ROBERT J
IPC: C07D207/16
Filed: 2017-10-04
Abstract: The invention discloses compounds of Formula (I) wherein R
Patent AU-2017363769-A1 (AU)
Title: Mobile robot and control method thereof
Inventor: NOH DONGKI
IPC: B25J19/06
Filed: 2017-11-21
Abstract: A mobile robot according to one aspect of the present invention comprises: a travel unit for moving a main body; an image acquisition unit for acquiring an image of the surroundings of the main body; a sensor unit comprising at least one sensor for detecting an obstacle while moving; a control unit for, when the sensor unit detects an obstacle, recognizing the attribute of the detected obstacle on the basis of the image acquired by the image acquisition unit, and controlling driving of the travel unit on the basis of the recognized attribute of the obstacle; and a sound output unit for outputting a predetermined sound when the recognized attribute of the obstacle indicates that the robot can pass over the obstacle, whereby stability, a user's convenience, operation efficiency, and cleaning efficiency can be improved.
Patent AU-2017363996-A1 (AU)
Title: Cooking temperature sensor with submersed probe
Inventor: STOUFER PAUL
IPC: A47J27/62
Filed: 2017-11-22
Abstract: A temperature sensor is provided for measuring a temperature of a liquid contained in a cooking vessel. The temperature sensor includes a first housing containing processing and wireless communication circuitry, a second housing containing a temperature probe, and a connecting member carrying wiring that connects the processing and wireless communication circuitry to the temperature probe. The temperature sensor also includes a fastener coupled to the first housing and configured to removably affix the temperature sensor to a sidewall of a cooking vessel such that the first housing is exterior to the cooking vessel, and the second housing extends over an interior bottom surface of the cooking vessel. The temperature probe is extendible from or retractable into the second housing to an adjustable height above the interior bottom surface of the cooking vessel and configured to measure a temperature of a liquid contained in the cooking vessel.
Patent AU-2017386403-A1 (AU)
Title: Power harvesting oral device
Inventor: DEMAREST SCOTT
IPC: A61N1/378
Filed: 2017-12-20
Abstract: An oral care implement may be embodied as an oral care device for placement in the oral cavity. The oral care device may include a support component, a piezoelectric component, and a therapeutic element. The support component is configured for placement between one or more maxillary teeth and one or more mandibular teeth. The piezoelectric element is configured to generate an electrical current from relative movement of the maxillary teeth and the mandibular teeth. The therapeutic element is electrically connected to the piezoelectric component and is configured to release a therapeutic composition into the oral cavity at least in part in response to receiving the electrical signal.
Patent AU-2017440239-A1 (AU)
Title: Compositions comprising omega-3 polyunsaturated and medium chain fatty acids
Inventor: JACKSON MATTHEW
IPC: A23K50/40
Filed: 2017-11-17
Abstract: Disclosed herein are pet food compositions for treating or preventing inflammation or an inflammatory disorder in an animal comprising an effective amount of at least one medium chain triglyceride and an effective amount of at least one omega-3 fatty acid, wherein the at least one medium chain triglyceride and the at least one omega-3 fatty acid are present in an amount effect to a provide a synergistic decrease in the amount of circulating cytokines in the companion animal. Also disclosed herein are methods for treating or preventing inflammation or an inflammatory disorder in a companion animal, comprising administering the pet food compositions disclosed herein to the companion animal in need thereof.
Patent AU-2018202027-A1 (AU)
Title: Cell culture device
Inventor: PANKRATZ GREGORY S
IPC: C12M1/22
Filed: 2018-03-21
Abstract: CELL CULTURE DEVICE A cell culturing device (10), comprising: a plurality of trays (12a, 12b, 12c, 12d), each tray having a bottom defining a cell growth surface (20) and at least one wall extending upwardly from the bottom, the bottom and the at least one wall defining, in combination with a bottom outer surface of an immediately adjacent tray in a stack, a volume configured to contain the cell growth surface (20) and including a headspace for gas exchange positioned above the cell growth surface (20) and below the bottom outer surface of the immediately adjacent tray in the stack, the at least one wall being configured to receive the immediately adjacent tray thereon; wherein a ratio of a number of the plurality of trays per a height dimension of the plurality of trays (12a, 12b, 12c, 12d) is greater than or equal to about 1 tray per 12 mm.
Patent AU-2018202222-A1 (AU)
Title: Cell culture medium comprising small peptides
Inventor: BARRETT SHAWN
IPC: C12N7/01
Filed: 2018-03-28
Abstract: Cell culture media, concentrated media and feeds, methods of manufacturing cell culture media and feeds, and methods of culturing cells are provided. One or more small 5 peptides, including dipeptides are added to the cell culture media to provide improved stability and improved conditions for culturing cells.
Patent AU-2018203998-A1 (AU)
Title: Novel viral replication inhibitors
Inventor: BARDIOT DOROTHÉE
IPC: C07D403/12
Filed: 2018-06-06
Abstract: The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a 5 medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably 0 for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.
Patent AU-2018204754-A1 (AU)
Title: Valsalva mask
Inventor: BORNHOLDT MELISSA CATHERINE
IPC: A61M16/00
Filed: 2018-06-29
Abstract: An interface for positive pressure therapy includes a mask assembly and a headgear assembly. The mask assembly comprises a mask seal that is adapted to underlie the nose. 5 The mask seal extends up the lateral sides of the nose. The mask seal has a primary seal below the nose and a secondary seal alongside the nose. -50-
Patent AU-2018211199-A1 (AU)
Title: Bollard accessory and system
Inventor: DALTON TRACEY ANN
IPC: E01F13/00
Filed: 2018-07-31
Abstract: The present invention relates to the field of barricades and barrier devices, such as a bollard for use in a public space and system of coverings therefore. In one particular aspect the present invention is suitable for use as a vehicle barrier. The present invention relates to a bollard accessory and method of installation comprising a removable installation member and one or more fastening means for removably attaching the installation member to one or more bollards. 5b Sa 4a 3b I3a -Gla
Patent AU-2018220033-A1 (AU)
Title: Pavement repair system
Inventor: COE WILLIAM B
IPC: E01C23/10
Filed: 2018-08-22
Abstract: A method for providing a cured paving or construction material, comprising: providing a paving or construction material comprising a rubber; and irradiating the mixture with radiation having a preselected peak wavelength of from 1 nm to 10000 nm, whereby a cured construction or paving 5 material is provided.
Patent AU-2018236701-A1 (AU)
Title: Polycyclic-carbamoylpyridone compounds and their use for the treatment of HIV infections
Inventor: DESAI MANOJ C
IPC: A61K31/4995
Filed: 2018-09-24
Abstract: H:\rbr\nterwoven\NRPortbl\DCCRBR\17745418_I.docx-20/09/2018 Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): R5" Z N (I)5 including stereoisomers and pharmaceutically acceptable salts thereof, wherein L, R , R',W, X, Y , Y , and Z are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also 10 disclosed.
Patent AU-2018236717-A1 (AU)
Title: Catheter with improved temperature response
Inventor: BEECKLER CHRISTOPHER THOMAS
IPC: A61B18/18
Filed: 2018-09-25
Abstract: A medical probe, consisting of an insertion tube having a distal end configured for insertion into a body of a patient and containing a lumen having an electrical 5 conductor for conveying electrical energy. The probe also has a conductive cap attached to the distal end of the insertion tube and coupled electrically to the electrical conductor, the cap including a side wall having multiple longitudinal bores therein. There are a plurality of 10 thermocouples disposed in respective ones of the longitudinal bores, and an electrically conductive cement at least partially fills the longitudinal bores so as to secure the thermocouples in the bores while making electrically conductive contact between the thermocouples 15 and the conductive cap. o0 D) z CN'
Patent AU-2018240405-A1 (AU)
Title: Use of Copaifera oleoresin in pathologies of the prostate
Inventor: FIORINI-PUYBARET CHRISTEL
IPC: A61P35/00
Filed: 2018-03-20
Abstract: The invention relates to a use of Copaifera oleoresin for producing a medicament for preventing and/or treating pathologies of the prostate, particularly benign prostatic hyperplasia and/or prostate cancer.
Patent AU-2018264057-A1 (AU)
Title: Improved compression seal
Inventor: HAIGH BRIAN
IPC: F16L19/10
Filed: 2018-11-15
Abstract: Abstract A compression seal for a plumbing fitting, in which one edge of the compression seal is permanently secured around one end of the plumbing fitting, to prevent loss, 5 damage or distortion of the seal; the seal being made of a resilient but compressible material and annular in form, the edge of the seal which is not to be secured permanently around one end of a plumbing fitting being formed with a taper on the interior surface of the seal, such that the seal decreases in thickness towards that edge. CNo Co K) C
Patent AU-2018264996-A1 (AU)
Title: Methods of treating Amyotrophic Lateral Sclerosis (ALS)
Inventor: MUELLER CHRISTIAN
IPC: C12N15/113
Filed: 2018-05-09
Abstract: Aspects of the disclosure relate to recombinant gene editing complexes comprising a recombinant gene editing protein and guide RNA (gRNA) that specifically hybridizes to a region of a C90RF72 gene (e.g., a region flanking a G
Patent AU-2018272869-A1 (AU)
Title: Method for laying a rail of a railway line
Inventor: PIGUET JEAN-CLAUDE
IPC: E01B29/44
Filed: 2018-05-18
Abstract: In order to lay a rail (12) of a railway line using a work train (4) comprising at least one heating device (32) having at least one heating zone (28), one or more gas burners (42), and one or more radiating bodies (44) arranged between the gas burner or burners (42) and the heating zone (28), the radiant body or bodies (44) being perforated by openings (46) opening into the heating zone (28), the work train (4) is moved in a laying direction (100), so that at each instant a portion of the rail to be fixed (12) crosses the heating zone (28); the heat is applied to the portion of the rail to be fixed (28) crossing the heating zone (28) using the heating device (32) by supplying the gas burner or burners (42) such that no flame emerges from the openings (46) in the heating zone (28) and such that at least 75%, and preferably at least 80%, and preferably at least 85% of the heat applied to the portion of the rail (12) is transmitted by radiation from the radiating body or bodies (44); then the portion of the rail (12) is fixed after applying the heat on a sleeper (10) of the railway line situated behind the heating zone (28) in the laying direction (100).
Patent AU-2018278711-A1 (AU)
Title: Device for transporting long welded rails
Inventor: DANZL ROBERT
IPC: B61D3/16
Filed: 2018-05-22
Abstract: The invention relates to a device (3) for transporting long welded rails (4) by means of a rail freight train, comprising an apparatus (8) for securely storing the rails (4). According to the invention, the device (3) is designed as a module unit having fasteners (5) for anchoring on a container flat car (2) and comprises a dedicated energy supply unit (9).
Patent AU-2018305892-A1 (AU)
Title: Assembly for storing heat
Inventor: BETKO HANS-JOACHIM
IPC: C09K5/14
Filed: 2018-07-23
Abstract: The invention relates to an assembly for storing thermal energy. The assembly comprises a spatial heat reservoir, a solid natural material, which is designed to store heat, and a fluid, which is designed to transfer thermal energy to the heat storage material and to remove thermal energy from the heat storage material. The heat storage material is arranged within the heat reservoir. The heat reservoir has at least one inlet and at least one outlet, through which the fluid is conducted in order to store energy and remove energy. In order to store energy, heated fluid is introduced into the heat reservoir through the inlet, thermal energy is transferred to the heat storage material there, and the fluid is conducted out of the heat reservoir through the outlet. Correspondingly, in order to remove energy, cool fluid is introduced into the heat reservoir through the inlet, thermal energy is absorbed from the heat storage material there, and the fluid is conducted out of the heat reservoir through the outlet. An igneous rock is used as the heat storage material.
Patent AU-2018316172-A1 (AU)
Title: Surgical frame including torso-sling and method for use thereof
Inventor: LIM ROY K
IPC: A61G13/04
Filed: 2018-08-08
Abstract: A torso-sling is provided to support at least a portion of the body of a patient on a surgical frame. The torso-sling is used in supporting at least a portion of the patient's torso. The torso-sling is supported relative to the surgical frame using a support bracket that can be attached to a chest support plate of the surgical frame. The torso-sling includes a frame portion, at least a first support strap, and at least a second support strap. The frame portion defines an access area, and the frame portion includes a first side portion, a second side portion, and a transition portion joining the first and second side portions together. The first side portion is configured for positioning adjacent a first lateral side on the posterior side of the patient, the second side portion is configured for positioning adjacent a second lateral side on the posterior side of the patient, and the transition portion is configured for positioning adjacent the neck and shoulders on the posterior side of the patient. The first support strap extends from the support bracket to the first side portion, the first support strap, when the patient is supported by the surgical frame and the torso-sling supports portions of the torso of the patient, extending in part adjacent portions of the first lateral side of the torso of the patient. The second support strap extends from the support bracket to the second side portion, the second support strap, when the patient is supported by the surgical frame and the torso-sling supports the portions of the torso of the patient, extending in part adjacent and contacting portions the second lateral side of the torso and the anterior torso of the patient.
Patent AU-2018320647-A1 (AU)
Title: Herbicidal composition
Inventor: DI MODUGNO ROCCO
IPC: A01N57/20
Filed: 2018-08-09
Abstract: Stable herbicidal compositions containing an ethoxylated esteramine as adjuvant.