Patent SG-11201803881R-A (SG)
Title: Synthetic vaccines against streptococcus pneumoniae serotype 2
Inventor: SEEBERGER PETER H
IPC: C07K16/00
Filed: 2016-12-16
Abstract: OHOH (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau 111111111111110 III OE III OE III II III 11111111111111111111 RIII 11111111 (10) International Publication Number WO 2017/103211 Al WIPO I PCT (43) International Publication Date 22 June 2017 (22.06.2017) (74) Agent: ARTH, Hans-Lothar; c/o ABK Patent Attorneys, Jasminweg 9, 14052 Berlin (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (51) International Patent Classification: A61K 39/00 (2006.01) CO7H 15/04 (2006.01) A61K 31/70 (2006.01) C07K 16/00 (2006.01) (21) International Application Number: PCT/EP2016/081586 (22) International Filing Date: 16 December 2016 (16.12.2016) English English (25) Filing Language: (26) Publication Language: (30) Priority Data: 15200729.0 17 December 2015 (17.12.2015) 16167505.3 28 April 2016 (28.04.2016) EP EP (71) Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. [DE/DE]; Hofgartenstrasse 8, 80539 Munich (DE). (72) Inventors: SEEBERGER, Peter H.; Rudolf-Breit- scheid-StraBe 46, 14532 Kleinmachnow (DE). PEREIRA, Claney Lebev; HortensienstraBe 66, 12203 Berlin (DE). ANISH, Chakkumkal; Vlaskamp 594, 2592AR Den Haag (NL). KHAN, Naeem; Luxemburger Str. 20C, 13353 Ber- lin (DE). EMMADI, Madhu; Stindestrasse 28, 12167 Berlin (DE). Published: — with international search report (Art 21(3)) (54) Title: SYNTHETIC VACCINES AGAINST STREPTOCOCCUS PNEUMONIAE SEROTYPE 2 H L'N 'w CRM197 W - 0 OH OH HO 0 HO HO °OH V* 0H O W O 20 17 / 103 211 Al m Figure 3 (57) : The present invention relates to a synthetic saccharide of general foiinula (I) that is related to Streptococcus pneumo - niaeserotype 2 capsular polysaccharide, a conjugate thereofand the use of said saccharide and conjugatefor raising a protective im- mune response in a human and/or animal host. Furthermore, the synthetic saccharide of general foiinula (I) isuseful as marker in im- munological assays fordetection of antibodies against Streptococcus pneumoniaetype 2 bacteria.