Patent SG-11201808849T-A (SG)
Title: Combinational therapies for treatment of cancer comprising a bacteriochlorophyll derivative
Inventor: SCHERZ AVIGDOR
IPC: A61P35/00
Filed: 2017-04-10
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization International Bureau .. .... ..Yejd 11M11111011101 1111111111010111110111010111110111111101100111111111110111111 (10) International Publication Number .... ..or::,,, (43) International Publication Date WO 2017/179053 Al 19 October 2017(19.10.2017) WIPO I PCT (51) International Patent Classification: (US). COLEMAN, Jonathan; c/o Memorial Sloan-Ketter- A61K 45/06 (2006.01) A61K 31/7068 (2006.01) ing Cancer Center, 1275 York Avenue, Box 524, New A61K 31/409 (2006.01) A61K 31/7135 (2006.01) York, New York 10065 (US). A61K 31/675 (2006.01) A61P 35/00 (2006.01) (74) Agents: BEN-AMI, Paulina et al.; BEN-AMI & ASSOCI- (21) International Application Number: ATES, P.O Box 94, 7610002 Rehovot (IL). PCT/IL2017/050440 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: 10 April 2017 (10.04.2017) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (26) Publication Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (30) Priority Data: 62/320,549 10 April 2016 (10.04.2016) US MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (71) Applicants: YEDA RESEARCH AND DEVELOP- MENT CO. LTD. [IL/IL]; at the Weizmann Institute of RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, T H, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Science, P.O. Box 95, 7610002 Rehovot (IL). MEMORI- AL SLOAN-KETTERING CANCER CENTER (84) Designated States (unless otherwise indicated, for every [US/US]; 1275 York Avenue, Box 524, New York, New York 10065 (US). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (72) Inventors: SCHERZ, Avigdor; 4 Tor Ha'aviv St., 7632104 Rehovot (IL). SALOMON, Yoram; c/o Yeda Research and Development Co. Ltd., Weizmann Institute of Science, P.O. Box 95, 7610002 Rehovot (IL). AGEMY, Lilach; c/o Yeda Research and Development Co. Ltd., Weizmann Institute of Science, P.O. Box 95, 7610002 Re- TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). hovot (IL). HAMRI, Rachel; c/o Yeda Research and De- Published: velopment Co. Ltd., Weizmann Institute of Science, P.O. — with international search report (Art. 21(3)) Box 95, 7610002 Rehovot (IL). PREISE, Dina; c/o Yeda Research and Development Co. Ltd., Weizmann Institute — before the expiration of the time limit for amending the of Science, P.O. Box 95, 7610002 Rehovot (IL). KIM, Kwanghee; c/o Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 524, New York, New York 10065 claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) Il M ir) 0 01 IN Il IN 1-1 (54) Title: COMBINATIONAL THERAPIES FOR TREATMENT OF CANCER COMPRISING A BACTERIOCHLOROPHYLL ei C:::: ) DERIVATIVE r .- (57) : An anti-myeloid-derived suppressor cells agent (\"anti-MDSCs agent\") and a bacteriochlorophyll derivative (herein - ,7 1 ,1 9 after \"Bchl-D) for use in combination therapy for cancer, wherein the anti-MDSC agent and the Bchl-D are administered sequen - .,. tially and the administration of the Bchl-D is followed by photodynamic therapy (PDT) or vascular targeted PDT (VTP).