baber/WOPTO huggingface dataset:
Patent EP-1806364-B1 (EP)
Inventor: GOETSCH LILIANE
IPC: G01N33/68
Filed: 2003-01-20
Granted: 2013-07-31
Abstract: An isolated antibody (Ab), and its functional fragments, that bind to human insulin-like growth factor-1 receptor (IGF-1R) and optionally: (i) inhibit natural binding of insulin-like growth factors (IGF)-1 and/or -2; and/or (ii) inhibit specifically tyrosine kinase activity of IGF-1R. An isolated antibody (Ab), and its functional fragments, that bind to human insulin-like growth factor-1 receptor (IGF-1R) and optionally inhibit natural binding of insulin-like growth factors (IGF)-1 and/or -2 and/or inhibit specifically tyrosine kinase activity of IGF-1R, is new. Ab comprises: (a) a light chain containing at least one complementarity-determining region (CDR) of one of 3 fully defined sequences comprising 16, 7 or 9 amino acids as given in the specification; or (b) a heavy chain containing at least one of the CDRs of one of 3 fully defined sequences comprising 6, 16 or 8 amino acids as given in the specification or sequences with 80% identity after optimal alignment. Independent claims are also included for the following: (1) murine hybridomas that secrete Ab; (2) an isolated nucleic acid (I) that: (a) is RNA or DNA and encodes Ab or its fragments; (b) is the complement of (a); or (c) has at least 18 nucleotides that can hybridize under stringent conditions with any of six sequences fully defined in the specification that encode the specified CDR, or with sequences having 80% identity after optimal alignment; (3) a vector containing (I); (4) a host cell containing the vector of (3); (5) a non-human transgenic animal containing at least one cell transfected with the vector of (3); (6) producing Ab or its fragments; (7) in vitro diagnosis of diseases induced by over- or under-expression of IGF-1R and or EGFR (epidermal growth factor receptor) by reaction with optionally labeled Ab; and (8) kit for performing method (7). ACTIVITY : Cytostatic; Antipsoriatic. The murine antibody 7C10, specific for IGF-1R, was tested (at 250 Microgram twice a week, intraperitoneally) against MCF-7 breast cancer cells, implanted in nude mice. After 37 days, the mean tumor volume was about 150 mm 3>; compared to about 800 mm 3> for controls and 300 mm 3> for animals treated with 10 Microgram tamoxifen. MECHANISM OF ACTION : Inhibition of signal transduction pathways mediated by IGF-1R, optionally also by epidermal growth factor (EGF) receptor, thus inhibiting growth and/or proliferation of tumor cells, especially where dependent on IGF, EGF, estrogens and/or HER2/neu.
Patent EP-1759962-B1 (EP)
Inventor: ANDRE GERALD
IPC: B62D25/20
Filed: 2006-09-04
Granted: 2009-02-18
Abstract: The floor has a lower part (12) with units for fixing to a front floor (22), and an upper part (14) with grooves to receive cross-members (18a, 18b) of a rear block (17b) in the body-in-white of a motor vehicle. A heel-board is dimensioned to fix to the front floor by overlapping with it over an overlapping range which is narrow in a station wagon type version of the vehicle and is broad in a four door saloon type version of the vehicle. The upper part has a hollow groove (26) to receive a passenger seat.
Patent EP-1862098-B1 (EP)
Inventor: LAN YUNG-HUEI
IPC: A47G29/087
Filed: 2006-03-14
Granted: 2013-11-20
Abstract: A sticker supporting member for a wall includes a base, adhesive member, and a supporting member. The supporting member is connected with the base. The adhesive member is a sticker having well effects on sealing the air and can be stuck on the smooth wall tightly. The adhesive member is stuck with the base and has a surface outward extended beyond the edges of the base. The characteristic is that a cross section of the side face of the base and the surface of the adhesive member is a transitional face extended from the edges of the base to the outer circumference of the adhesive member. The supporting member can easily squeeze out the air between the sticker and the base. The metal layer in the base can prevent the air permeating between the sticker and the wall to avoid peeling. The present invention can be widely applied in living.
Patent EP-1857644-B1 (EP)
Inventor: KIRA NAOKI
IPC: F01L1/34
Filed: 2006-02-10
Granted: 2012-01-11
Abstract: カムシャフトの軸方向の内燃機関の全長の増加を抑えつつカムシャフトの一方の端部に被駆動装置と弁開閉時期制御装置の両方を取り付け可能とし、更に、汎用性が高く重量の増加も抑えることが可能な弁開閉時期制御装置を提供する。 　クランクシャフトに同期回転する駆動側回転部材５、５１、５２と、該駆動側回転部材５、５１、５２に同軸状に配置された従動側回転部材４と、該従動側回転部材４の軸方向一端側から軸方向他端側へ貫通し、従動側回転部材４の軸方向他端側でカムシャフト３に締結して従動側回転部材４をカムシャフト３に固定する締結部材７と、を備え、駆動側回転部材５、５１、５２に対して軸方向一端側に配置され、被駆動装置９を取り付けるための係合溝８１を有する係合手段８が、締結部材７の軸方向一端部に一体的に設けられている。
Patent EP-1861343-B1 (EP)
Inventor: SCHERER STEFAN
IPC: C07C67/30
Filed: 2006-03-07
Granted: 2009-03-04
Abstract: L'invention concerne un procédé pour la production de composés aromatiques et hétéroaromatiques (III) à substitution alkyle, par couplage croisé d'acides alkylboroniques (II) avec des halogénures d'aryle ou d'hétéroaryle ou des arylsulfonates ou hétéroarylsulfonates (I), en présence d'un catalyseur et d'une base de Brönsted dans un solvant ou un mélange de solvants. Hal représente chlore, brome, iode, trifluorométhane sulfonate, nonafluoro-triméthylméthane sulfonate, méthanesulfonate, 4-toluènesulfonate, benzènesulfonate, 2-naphtalènesulfonate, 3-nitrobenzènesulfonate, 4-nitrobenzènesulfonate, 4-chlorobenzènesulfonate ou 2,4,6-triisopropyl-benzènesulfonate ; X1-5 représentent indépendamment les uns des autres carbone ou XiRi représente azote ou respectivement deux XiRi voisins reliés par une liaison double formelle représentent ensemble O (furanes), S (thiophènes), NH ou NRi (pyrroles) ; les restes R1-5 représentent des substituants sélectionnés dans le groupe contenant hydrogène, méthyle, des restes alkyle cycliques ou acycliques primaires, secondaires ou tertiaires ayant 2 à 20 atomes de C dans lesquels un ou plusieurs atomes d'hydrogène sont éventuellement remplacés par fluor, chlore ou brome, par exemple CF3, des groupes alkyle substitués cycliques ou acycliques, hydroxy, alcoxy, amino, alkylamino, dialkylamino, arylamino, diarylamino, alkylarylamino, phényle, phényle substitué, hétéroaryle, hétéroaryle substitué, thio, alkylthio, arylthio, diarylphosphino, dialkylphosphino, alkylarylphosphino, aminocarbonyle éventuellement substitué, CO2-, alkyl- ou aryloxycarbonyle, hydroxyalkyle, alcoxyalkyle, fluor ou chlore, nitro, cyano, aryl- ou alkylsulfone, aryl- ou alkylsulfonyle, ou bien respectivement deux restes R1-5 voisins représentent ensemble un cycle aromatique, hétéroaromatique ou aliphatique condensé ; Alkyl représente des restes alkyle linéaires, ramifiés ou cycliques quelconques ayant 1 à 40 atomes de C dans lesquels un ou plusieurs atomes d'hydrogène sont éventuellement substitués par des atomes étrangers ou des fonctions du groupe contenant fluor, éventuellement chlore ou brome, hydroxy, alcoxy, amino, alkylamino, dialkylamino, arylamino, diarylamino, alkylarylamino, phényle, phényle substitué, hétéroaryle, hétéroaryle substitué, thio, alkylthio, arylthio, diarylphosphino, dialkylphosphino, alkylarylphosphino, aminocarbonyle éventuellement substitué, CO2-, alkyl- ou aryloxycarbonyle, hydroxyalkyle, alcoxyalkyle, fluor ou chlore, nitro, cyano, aryl- ou alkylsulfone ; R' et R' représentent indépendamment l'un de l'autre des restes identiques ou différents sélectionnés dans le groupe contenant hydrogène, méthyle, alkyle linéaire, ramifié ou cyclique éventuellement substitué, phényle éventuellement substitué ou forment ensemble un cycle et représentent un motif constitutif de pontage sélectionné dans le groupe contenant alkylène éventuellement substitué, alkylène ramifié, alkylène cyclique ou aza-alkylène éventuellement substitué.
Patent EP-1858639-B1 (EP)
Inventor: SOHLING ULRICH
IPC: A23L5/20
Filed: 2006-03-17
Granted: 2012-02-15
Abstract: The invention relates to a method for separating biomolecules from a liquid media consisting in preparing and treating a liquid biomolecule-containing medium by means of a clay material whose specific surface is greater than 180 m<SUP>2</SUP>/g, pore volume is greater than 0.35 ml/g, cation-exchange capacity is higher than 40 meq/100 g and sediment volume in water is less than 15 ml/2 g, wherein the purified liquid medium is separated from said clay material.
Patent EP-2022827-B1 (EP)
Inventor: MAEDA MUTSUMI
IPC: C08J3/22
Filed: 2006-05-12
Granted: 2013-07-03
Abstract: A method for producing a conductive polyamide-polyphenylene ether resin composition comprising (A) 10 to 90 parts by mass of a polyphenylene ether resin, (B) 5 to 85 parts by mass of a polyamide having a (terminal amino group)/(terminal carboxyl group) ratio falling within the range from 0.20 to 4.0, (C) 5 to 85 parts by mass of a polyamide having a (terminal amino group)/(terminal carboxyl group) ratio falling within the range from 0.05 to 0.19 and (D) 0.1 to 10 parts by mass of a conductive filler, the method comprising the step of melt-kneading of the component (A), the component (B), a compatibilizer (F) and a master batch (E) obtained by melt-kneading of the component (D) and the component (C) in advance.
Patent EP-1866409-B1 (EP)
Inventor: MARKERT M LOUISE
IPC: A61K35/26
Filed: 2006-03-22
Granted: 2011-10-12
Abstract: A method of treating hypoparathyroidism in a human DiGeorge syndrome subject comprises (a) implanting thymus tissue into the subject in an amount effective to treat the DiGeorge syndrome; and (b) implanting, preferably concurrently implanting, parathyroid tissue into the subject in an amount effective to treat the hypoparathyroidism.
Patent EP-2008333-B1 (EP)
Inventor: DARLING ROBERT M
IPC: H01M8/10
Filed: 2006-04-07
Granted: 2011-04-06
Abstract: A composite electrolyte membrane (10) for a fuel cell (30) includes an ionomer component (16) extending continuously between opposed first and second contact surfaces (12, 14) defined by the membrane (10). The ionomer component is a hydrated nanoporous ionomer consisting of a cation exchange resin. The membrane (10) also includes a microporous region (18) consisting of the ionomer compound (16) and a structural matrix (20) dispersed through region (18) within the ionomer compound (16) to define open pores having a diameter of between 0.3 and 1.0 microns. The microporous region (18) does not extend between the contact surfaces (12, 14), and facilitates water management between the electrode catalysts (32, 34).
Patent EP-1901934-B1 (EP)
Inventor: REHRA GUENTER
IPC: B60G17/052
Filed: 2006-06-06
Granted: 2009-08-12
Abstract: Disclosed is a pneumatic shock absorbing system (1) for a motor vehicle, comprising at least one pneumatic spring (18a, 18b, 18c, 18d) per motor vehicle wheel on at least one vehicle axle, at least one control device (36), at least one compressor (2), at least one pressure sensor (10), at least one on-off valve (20a, 20b, 20c, 20d), and at least one connecting pipe (8, 16a, 16b, 16c, 16d, 62, 64) which is connected to an external source (76) of compressed air. The control device (36) of the pneumatic shock absorbing system (1) receives a start signal for basic filling while at least one valve (20a, 20b, 20c, 20d) is triggered by the control device (36) in such a way that at least one component (8, 16a, 16b, 16c, 16d, 18a, 18b, 18c, 18d, 62, 64) of the pneumatic shock absorbing system (1) is basically filled.
Patent EP-1877675-B1 (EP)
Inventor: KULBE ROLAND
IPC: F16D48/08
Filed: 2006-04-26
Granted: 2008-09-10
Abstract: L'invention concerne un procédé d'identification d'un point de frottement d'un embrayage, cet embrayage étant relié à un moteur d'entraînement. Selon ce procédé, le régime du moteur d'entraînement et les valeurs de vitesse des roues entraînées par ledit moteur sont déterminés. L'invention concerne en outre un dispositif pour mettre en oeuvre ce procédé. Selon l'invention, le point de frottement exact de l'embrayage étant nécessaire par exemple comme critère de desserrage pour un processus de desserrage automatique d'un frein de stationnement électrique d'un véhicule automobile, un rapport de transmission (f) correspondant au quotient des valeurs de vitesse des roues (vrad) et du régime (n) du moteur d'entraînement est déterminé et le point de frottement de l'embrayage est fixé lorsque le rapport de transmission (f) et le régime (n) du moteur d'entraînement présentent un minimum local.
Patent EP-1886545-B1 (EP)
Inventor: MERLET ETIENNE
IPC: H05K7/14
Filed: 2006-05-29
Granted: 2008-07-16
Abstract: The invention concerns a wedge (12) comprising: a plate (13), and actuator (16) mounted on the plate (13) while being mobile relative thereto between an active position and an inactive position; a wedge element (19) mounted on the plate (13) and coupled to said actuator (16), said wedge element (19) being deformable between: an inactive configuration, adopted in inactive position of the actuator (16), wherein the wedge element (19) extends in the vicinity of the plate (13), and an active configuration, adopted in the active position of the actuator (16), wherein the wedge element (19) is in straight position while being at least locally spaced apart from the plate (13). The invention also concerns a system comprising a module, a receptacle and such a wedge interposed between them.
Patent EP-1905107-B1 (EP)
Inventor: YOUNG EDWARD W A
IPC: H01L51/00
Filed: 2006-06-26
Granted: 2009-09-30
Abstract: A device comprising a first transparent and electrically conductive layer (102), a second electrically conductive layer (104), and a functional layer (103) comprising at least one organic layer, sandwiched between said first and second conductive layers and to form a functional organic stack. At least one via (110) is arranged to electrically interconnect said first layer (102) and at least one segment (112) of said second layer (104), the segment being electrically insulated from the reminder of the second layer. The present invention makes it possible to uniformly supply the first transparent layer with electrical power. The vias and segments are preferably formed by laser applied through the transparent conductive layer.
Patent EP-1897297-B1 (EP)
Inventor: GUICHARD JAMES N
IPC: H04L12/56
Filed: 2006-06-28
Granted: 2011-08-10
Abstract: An MPLS router operable for labeled switch path (LSP) operation defines a compression index for identifying a decompression context between other MPLS LSP routers. The compression index allows a multipoint-to-point link between MPLS routers, thereby avoiding an exhaustive mesh of point-to-point links between each of the MPLS routers. The originator ID identifies each of the multipoint originating endpoints at a common destination, and maintains the context of each compressed header to match incoming compressed headers to the corresponding header values. The originator ID, typically the IP address of the originator, operates as the compression index on the multipoint-to-point connection, operable to distinguish multiple originators of the multipoint-to-point connection and provide header compression for each.
Patent EP-1920079-B1 (EP)
Inventor: MUHA JOSEPH F
IPC: C22C33/02
Filed: 2006-08-10
Granted: 2009-05-13
Abstract: A fully dense, powder-metallurgy produced maraging steel alloy article of prealloyed powder for use as a tool for high temperature applications. The article in the as-produced condition having a hardness less than 40 HRC to provide machinability and thereafter the article upon maraging heat treatment having a hardness greater than 45 HRC. A method for producing this article comprises compacting prealloyed powder to produce a fully dense article having a hardness less than 40 HRC and thereafter maraging heat treating to a hardness greater than 45 HRC.
Patent EP-1922189-B1 (EP)
Inventor: ZEEB SCOTT M
IPC: B24B3/46
Filed: 2006-08-16
Granted: 2011-11-23
Abstract: A food slicer has a support member including a base portion and an upstanding portion integrally formed with the base portion. The upstanding portion includes a rotating cutting blade for slicing food product. The base portion includes a food product table slidably secured thereto for movement across the cutting blade for holding product while it is being sliced. An adjustable gage plate is provided for determining the thickness of a food product to be sliced. A sharpening mechanism for sharpening the cutting blade as needed is removably secured to a portion of the product table to provide accurate sharpening of the cutting blade. The sharpening mechanism includes a first rotating sharpening member and a second deburring member where the first and second members are mounted independent from each other.
Patent EP-1957218-B1 (EP)
Inventor: LAEMPE JOACHIM
IPC: B22C15/24
Filed: 2006-09-21
Granted: 2011-05-11
Abstract: The production of molds or cores by blasting a mixture of sand and binder through orifices (7) in a blasting plate (5) into a mold or core tool (8) and wetting the mixture between blasts comprises ultrasonically atomizing the wetting liquid (15) and supplying the resulting aerosol to a blasting unit (2). An independent claim is also included for an apparatus for the production of molds or cores from a mixture of sand and binder, comprising a blasting unit consisting of a blast pipe (3) and a blast head (4) with a blasting plate having orifices, and an ultrasonic atomizer for water or aqueous liquid connected to the blasting plate orifices.
Patent EP-1974647-B1 (EP)
Inventor: ZHOU HONG
IPC: A47L13/22
Filed: 2006-12-08
Granted: 2010-08-18
Abstract: A steam floor mop comprises: a handle; a body inside which a manual water pump, a water tank, and a steam generator are provided; and a floor brush connected slidably to the body. The manual water pump, the water tank the steam generator and the floor brush are connected by means of pipes. Said handle is connected directly to a piston rod in the manual water pump and serves to manipulate the operation of the manual water pump. Said floor brush is covered by a cleaning cloth.
Patent EP-1955058-B1 (EP)
Inventor: LAU ALDRICH N K
IPC: C12Q1/68
Filed: 2006-11-13
Granted: 2011-04-13
Abstract: Microfluidic devices that incorporate a porous polymer electrode assemblies, including microfluidic device useful for detection of nucleic acids, as well as methods of using the microfluidic devices.
Patent EP-2054373-B1 (EP)
Inventor: DESHPANDE PANDURANG BALWANT
IPC: C07C269/04
Filed: 2006-10-06
Granted: 2010-06-30
Abstract: The present invention relates to an improved process for preparation of Rivastigmine of formula (I) or pharmaceutically acceptable salts thereof comprising a step of N-methylation of compound of formula (III), wherein R1=R2=H or R1=H and R2=CH3 or an acid addition salt thereof, using paraformaldehyde in the presence of Raney Nickel and hydrogen in a suitable solvent to obtain compound of formula (II).
Patent EP-1862622-B1 (EP)
Inventor: MARTON LASZLO
IPC: E05F7/08
Filed: 2007-01-12
Granted: 2008-08-06
Abstract: To produce a corner connection, there is a positive-locking retainer (43) on a first turned-over rail leg (TORL) (4) for longitudinal support (LS) and a positive-locking projection (PLP) (47) for crosswise support (CS). A second TORL (11) has a PLP (24) for LS shaped as a hook molded as a uniform component onto the second TORL.
Patent EP-1864695-B1 (EP)
Inventor: LEINEMANN CHRISTOPH DIPL-ING
IPC: B23H9/00
Filed: 2007-04-19
Granted: 2009-12-30
Abstract: A boring (6) insertion method requires total axial closure of the coiled flame trap arrangement (1), which consists of two coiled metal strips or bands with a circular outer periphery. Total closure on both sides is achieved with retention plates (5), and from the outer periphery the boring is inserted radially inwards with a spark erosion electrode (7) under the effect of a coolant liquid. An independent claim is included for a flame-trap consisting of two coiled metal plates formed, in common, into a disc with circular outer periphery.
Patent EP-1852007-B1 (EP)
Inventor: MARQUERING JOHANNES DR
IPC: G07C5/00
Filed: 2007-04-26
Granted: 2009-02-25
Abstract: The system has a diagnostic and/or service computer (6), and an agricultural on board computer (2) connectable with the diagnostic and/or service computer by a data communication device. The diagnostic and/or service computer is provided with an operating device (8) and a screen-like display (9). An image (10) of a displaying and operating device of the on board computer is represented on the screen-like display. Input instructions are transmitted to the on board computer by the diagnostic and/or service computer, so that the computer is adjustable, controllable and/or regulatable.
Patent EP-1981238-B1 (EP)
Inventor: XING XIANWU
IPC: H04L29/06
Filed: 2007-07-04
Granted: 2011-09-21
Abstract: A prefix matching algorithm and method thereof are disclosed. The prefix matching engine for matching prefix of an input stream against prefixes of predefined signatures includes a prefix logic, a prefix look-up table storing prefix information of the predefined signatures and a table entry buffer. According to a portion of the input stream, the prefix logic is capable of accessing a predetermined number of table entries in the prefix look-up table and stores table entry values of the predetermined number of table entries in the table entry buffer. By examining the temporary table entry values in the table entry buffer, the prefix logic determines whether a prefix matching is found.
Patent EP-1854623-B1 (EP)
Inventor: VADHAR PARIMAL
IPC: B32B3/00
Filed: 2003-01-14
Granted: 2014-09-10
Abstract: A microwaveable package includes a support member; a bottom web; a food product; and a top web; where the seal between the top and bottom webs has a peel strength, before microwaving, of at least 4 pounds per inch, and a peel strength, after microwaving, of less than 2.5 pounds per inch. Alternatively, a microwaveable package includes a support member; a bottom web; a food product; and a top web; where the top web includes a sealant layer comprising an ethylene/alpha olefin copolymer, and the bottom web includes a sealant layer comprising a blend of between 60% and 90%, by weight of the sealant layer, of ethylene/vinyl acetate copolymer, and between 10% and 40%, by weight of the sealant layer, of polypropylene. Methods of making the microwaveable packages are also disclosed.
Patent EP-1869968-B1 (EP)
Inventor: DE VRIES SJOERD SIEGER
IPC: A01D87/10
Filed: 2007-06-19
Granted: 2009-11-18
Abstract: Crop-processing device with a pick-up/cutting device (1, 10) for picking up and cutting an agricultural product. The crop-processing device furthermore has a discharge duct (30) for discharging cut agricultural product from the crop-processing device, in which discharge duct (30) first and second rotating accelerating elements (21, 24) are arranged for conveying the cut agricultural product through the discharge duct (30) by means of contact with the cut agricultural product.  The peripheral speed of the second accelerating element (24) is greater than the peripheral speed of the first accelerating element (21). As a result, the acceleration up to the desired discharge speed, and thus the discharge of the product, is more uniform. Furthermore, the device requires less power than the known crop-processing devices.
Patent EP-1998408-B1 (EP)
Inventor: IDZIK JACEK
IPC: H01R12/71
Filed: 2007-04-25
Granted: 2010-02-24
Abstract: Various embodiments are provided herein for a connector that can provide electrical and mechanical coupling between first and second objects. The connector generally comprises at least one connecting element that has at least one first and second contact portion, at least one guidance portion located towards the end of the at least one connecting element and adjacent to one of the at least one first and second contact portions; and a biasing portion that is adjacent to the at least one first and second contact portions. The biasing portion is configured to provide an electrical connection between the at least one first and second contact portions and to resiliently move the at least one connecting element from a first position to a second position to provide a mechanical coupling force to the first and second objects.