Patent SG-11201907855Q-A (SG)
Title: Multispecific binding proteins targeting caix, ano1, mesothelin,trop2, cea, or claudin-18.2
Inventor: CHANG GREGORY
IPC: A61K39/00
Filed: 2018-02-27
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 30 August 2018 (30.08.2018) WIPO I PCT onion °nolo OH loom DID Ho Imo oimIE (10) International Publication Number WO 2018/157147 Al (51) International Patent Classification: A61K 39/00 (2006.01) C07K 16/28 (2006.01) A61K 39/395 (2006.01) C07K 16/46 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/US2018/019999 (22) International Filing Date: 27 February 2018 (27.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/464,347 27 February 2017 (27.02.2017) US 62/464,344 27 February 2017 (27.02.2017) US 62/464,341 27 February 2017 (27.02.2017) US 62/467,557 06 March 2017 (06.03.2017) US 62/473,652 20 March 2017 (20.03.2017) US 62/473,659 20 March 2017 (20.03.2017) US KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (71) Applicant: DRAGONFLY THERAPEUTICS, INC. [US/US]; 35 Gatehouse Drive, Waltham, MA 02451 (US). (72) Inventors: CHANG, Gregory, P.; 143 Saunders Street, Medford, MA 02155 (US). CHEUNG, Ann, F.; 25 Morn- ingside Lane, Lincoln, MA 01773 (US). GUTIERREZ, Eva; 67 Hillcrest Street, Waltham, MA 02451 (US). HANEY, William; 61 Lincoln Road, Wayland, MA 01778 (US). LUNDE, Bradley, M.; 7 Lucent Drive, Lebanon, NH 03766 (US). PRINZ, Bianka; 7 Lucent Drive, Lebanon, NH 03766 (US). (74) Agent: ASHRAF, Shovon et al.; Goodwin Procter LLP, 100 Northern Avenue, Boston, MA 02210 (US). = (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (54) Title: MULTISPECIFIC BINDING PROTEINS TARGETING CAIX, ANO1, MESOTHELIN,TROP2, CEA, OR CLAUDIN-18.2 FIG. 1 (57) : Multi-specific binding proteins that bind the NKG2D receptor, CD 16, and a tumor-associated antigen selected from carbonic anhydrase 9 (CAIX), anoctamin-1 (ANO1), mesothelin, TROP2, CEA and claudin-18.2 are described, as well as pharmaceutical composi- tions and therapeutic methods useful for the treatment of cancer. W O 20 18/ 157147 A