baber/WOPTO huggingface dataset:
Patent AU-572194-B2 (AU)
Title: Azetidinone derivatives
Inventor: SCHMID GERARD
IPC: C07D205/08
Filed: 1984-09-28
Granted: 1988-05-05
Abstract: 1. A process for the manufacture of optically uniform azetidinones of the general formula  see diagramm : EP0138113,P5,F1  wherein R signifies benzyl, beta-(trimethylsilyl)-lower alkyl or beta-halo-lower alkyl, R**1 signifies a readily cleavable protecting group from the group consisting of benzyl, 2,4- or 3,4-di(lower alkoxy)benzyl, di[4-(lower alkoxy)phenyl]methyl, 4-(lower alkoxy)phenyl, lower 2-alkenyl and the group of the formula -CH2 -CH(OR**5)2 (a) or  see diagramm : EP0138113,P5,F2  in which R**5 signifies lower alkyl and n signifies the number 0 or 1, R**2 signifies lower alkyl, phenyl-lower alkyl or lower alkoxyalkyl and R**3 signifies lower alkyl or phenyl-lower alkyl or R**2 and R**3 together with the centre of chirality and the oxygen atom signify a 5 or 6-membered 0-heterocycle which optionally contains a further oxygen atom not directly linked with the centre of chirality and which is optionally substituted by lower alkyl, lower alkoxy, oxo or spirocyclo-lower alkyl, and the residues denoted by lower have up to eight carbon atoms, characterized by reacting an alkali metal salt of a carboxylic acid of the general formula ROCONHCH2 COOH wherein R has the above significance, with an optically uniform compound of the general formula  see diagramm : EP0138113,P6,F3  wherein R**1, R**2 and R**3 have the above significance, in the presence of a base and a sulphonic acid chloride of the general formula R**4-SO2 -Cl wherein R**4 signifies phenyl, lower alkylphenyl, halophenyl, lower alkyl or halo-lower alkyl, whereby the reaction is carried out in an anhydrous inert organic solvent at a temperature in the range of about -30 degrees C to about 50 degrees C.
Patent AU-697311-B2 (AU)
Title: Combined preparation for the therapy of immunological diseases
Inventor: SCHONHARTING MARTIN
IPC: A61K45/06
Filed: 1995-08-07
Granted: 1998-10-01
Abstract: A combination preparation comprising a compound which has a phosphodiesterase-inhibiting action, and a compound which reduces the biologically effective intracellular Ca2+ content, is suitable for the treatment of immunological diseases.
Patent AU-665230-B2 (AU)
Title: Sulfonamidocarboxamide
Inventor: ACKERMANN JEAN
IPC: C07C279/16
Filed: 1993-03-01
Granted: 1995-12-21
Abstract: The novel sulphonamidocarboxamides of the formula <IMAGE>  in which     X is a group of the formula X<1> or X<2>: <IMAGE>   T is CH2 or O, and A, M, Q and Y have the meaning given in the description, and hydrates or solvates thereof inhibit the platelet aggregation and clotting of fibrinogen in the plasma induced by thrombin. They are prepared by amidination of a cyclic amino group representing the group X or by C(O)Q amide formation.
Patent AU-628818-B2 (AU)
Title: Tomatoes
Inventor: BRIDGES IAN GEORGE
IPC: A01H5/00
Filed: 1989-05-11
Granted: 1992-09-24
Abstract: Fruit, especially tomatoes, having lowered expression of fruit-softening enzymes caused by antisense gene expression, and seeds therefrom.
Patent AU-659289-B2 (AU)
Title: An apparatus for moderating temperature of a powder being sintered and an apparatus for producing a part from a powder
Inventor: DECKARD CARL R
IPC: B23K26/08
Filed: 1993-03-17
Granted: 1995-05-11
Abstract: A method and apparatus (10) for selectively sintering a layer of powder to produce a part comprising a plurality of sintered layers. The apparatus includes a computer (40) controlling a laser (12) to direct the laser energy onto the powder to produce a sintered mass. The computer either determines or is programmed with the boundaries of the desired cross-sectional regions of the part. For each cross-section, the aim of the laser beam is scanned over a layer of powder and the beam is switched on to sinter only the powder within the boundaries of the cross-section. Powder is applied and successive layers sintered until a completed part is formed. The powder may consist of a plastic, metal, ceramic, or polymer substance. In the preferred embodiment, the aim of the laser is directed in a continuous raster scan and the laser turned on when the beam is aimed within the boundaries of the particular cross-section being formed. Preferably, the powder dispensing mechanism includes a drum which is moved horizontally across the target area and counter-rotated to smooth and distribute the powder in an even layer across the target area. A downdraft system provides controlled temperature air flow through the target area to moderate powder temperature during sintering. <IMAGE>
Patent AU-615548-B2 (AU)
Title: Binder compositions comprising low molecular weight poly(orthomethylolated) phenolic compound and novolac resin
Inventor: GERBER ARTHUR H
IPC: C08G8/24
Filed: 1989-05-29
Granted: 1991-10-03
Abstract: The invention relates to a binder composition comprising a low molecular weight poly (orthomethylolated) phenolic compound which is combined with a phenol formaldehyde novolac resin and cured in the presence of alkali and an organic ester. Low and high density aggregates can be added to the binder to produce foundry or refractory articles. The binder can also be applied, with or without aggregate, to paper, fabrics, or concrete.
Patent AU-771615-B2 (AU)
Title: Coupled polymerase chain reaction-restriction endonuclease digestion-ligase detection reaction process
Inventor: BARANY FRANCIS
IPC: C12Q1/6816
Filed: 2000-03-17
Granted: 2004-04-01
Abstract: The present invention provides a method for identifying one or more low abundance sequences differing by one or more single-base changes, insertions, or deletions, from a high abundance sequence in a plurality of target nucleotide sequences. The high abundance wild-type sequence is selectively removed using high fidelity polymerase chain reaction analog conversion, facilitated by optimal buffer conditions, to create a restriction endonuclease site in the high abundance wild-type gene, but not in the low abundance mutant gene. This allows for digestion of the high abundance DNA. Subsequently the low abundant mutant DNA is amplified and detected by the ligase detection reaction assay. The present invention also relates to a kit for carrying out this procedure.
Patent AU-632496-B2 (AU)
Title: Novel peptide derivatives and antidementia agents
IPC: A61K38/00
Filed: 1989-08-14
Granted: 1993-01-07
Abstract: A novel peptide derivative having the formula: <CHEM> wherein A between Pro and Q<2> is Arg or Lys: Q<1> is pGlu or H; Q<2> is -Gly-OH or OH; Y<1> is H or -CO-T and Y<2> is OH or T; wherein T is a thiamine derivative group is disclosed. The peptide derivative shows a remarkable nootropic effect.
Patent AU-679182-B2 (AU)
Title: Antibody assay for amylin
Inventor: PHELPS JULIE L
IPC: G01N33/53
Filed: 1993-05-17
Granted: 1997-06-26
Abstract: A monoclonal antibody which binds at the C-terminal end of human amylin, and assays using such monoclonals for the detection of amylin and amylin analogs.
Patent AU-784173-B2 (AU)
Title: Modified cytokines for use in cancer therapy
Inventor: CORTI ANGELO
IPC: C12N15/62
Filed: 2001-02-13
Granted: 2006-02-16
Abstract: Cytokine derivatives capable of homing the tumoral vessels and the antigen presenting cells and the use thereof as antitumoral agents.
Patent AU-742972-B2 (AU)
Title: Hedgehog interacting proteins and uses related thereto
Inventor: MCMAHON ANDREW P
IPC: A61K48/00
Filed: 1997-09-19
Granted: 2002-01-17
Abstract: The present invention concerns the discovery of a new family of hedgehog binding proteins, referred to herein as "hedgehog interacting proteins" or "HIPs", which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the vertebrate HIP proteins exhibit spatially and temporally restricted expression domains indicative of important roles in hedgehog-mediated induction.
Patent AU-616579-B2 (AU)
Title: Substituted thiazoles and their use as fungicides
Inventor: ALT GERHARD HORST
IPC: A61L/
Filed: 1989-11-28
Granted: 1991-10-31
Abstract: Substituted 5-carboxanilidothiazoles represented by the formula: <CHEM> wherein each R is independently halo, halomethyl, 1-haloethyl, halomethoxy, 1-haloethoxy, halomethylthio, 1-haloethylthio, pentafluorosulfur, halomethylsulfinyl, 1-haloethylsulfinyl, halomethylsulfonyl or 1-haloethylsulfonyl; R1 and R2 are independently methyl, ethyl or halomethyl, provided that at least R1 or R2 is halomethyl; and n is an integer from 1 to 5; and their agronomically acceptable salts, are useful as fungicides.
Patent AU-707041-B2 (AU)
Title: Medicinal fluid pump having multiple stored protocols
Inventor: MARTTILA CONSTANCE M
IPC: A61M5/142
Filed: 1996-01-05
Granted: 1999-07-01
Abstract: A pump (23) used to infuse a fluid into a patient (27) is controlled in accordance with a plurality of parameters entered by an operator. These parameters define a protocol that is applied in controlling the operation of the pump to determine the rate, volume, and timing of the fluid infusion. The operator enters the parameters using a keypad (16) in response to prompts provided on a display (18). Once the parameters for a current protocol are entered, they can be stored as a speed protocol by selecting that option from a menu appearing on the display. Up to three speed protocols can be stored in memory in the disclosed preferred embodiment. When preparing to infuse a medicinal fluid, an operator can elect to enter a new protocol or to select an appropriate speed protocol stored in memory for loading as the current protocol. Use of stored speed protocols saves time and reduces the likelihood of errors that can occur when data defining the parameters controlling the infusion process are entered by an operator.
Patent AU-580347-B2 (AU)
Title: Fabricating cylindrical bodies by plastic deformation
Inventor: BALINT LUDWIG
IPC: B21H9/00
Filed: 1985-10-15
Granted: 1989-01-12
Abstract: A process and machine for fabricating a rotation body having different diameters along the length thereof is disclosed, in which a blank is rotated and worked between two pressure zones to apply thereto a local pressure exceeding the flow limit of the blank material whereby circularly extending impressions of the different diameters are worked into the blank, the pressure zones crossing each other. The pressure zones are displaced relative to each other while applying the local pressure, the displacement motion having a component extending in the longitudinal direction of at least one of the pressure zones and the points of intersection of the crossing pressure zones forming a geometric line, and the blank is displaced in dependence on this line and on the different diameters to be produced.
Patent AU-665126-B2 (AU)
Title: Anti-inflammatory, tolerogenic and immunostimulatory properties of carbohydrate binding-proteins
Inventor: SMITH RICHARD
IPC: A61P11/00
Filed: 1993-10-04
Granted: 1995-12-14
Abstract: The invention is directed to a lectin derived carbohydrate binding-peptide which inhibits cell-mediated immune responses and has the amino acid sequence SPYGRC. The peptide binds terminally linked  alpha -sialic acid (2->3) beta Gal- and  alpha -sialic (2->6) beta Gal-structures and is a acid fragment of the S2 subunit of pertussis toxin produced by Bordetella pertussis.
Patent AU-637354-B2 (AU)
Title: Genetic units for inhibiting the function of rna
IPC: C12N9/00
Filed: 1990-03-15
Granted: 1993-05-27
Abstract: The invention relates to a genetic unit, which is optionally in multicopy form, for the inhibition of RNA. The unit contains the transcription units necessary for transcription by polymerase III, and a DNA which codes for inhibiting RNA and which is arranged within the unit in such a way that the transcribed RNA is part of the polymerase III transcript. These units can be used to achieve increased stability of the inhibiting RNA, which can be in the form of ribozymes or antisense RNAs, while there is no reduction in the activity. The invention furthermore relates to a process for introducing the genetic units into the cell, to the use of these units and to pharmaceutical formulations containing them.
Patent AU-668257-B2 (AU)
Title: Two part surgical fastener
Inventor: LUSCOMBE BRIAN H
IPC: A61B17/08
Filed: 1994-01-25
Granted: 1996-04-26
Abstract: A method of tissue compression is disclosed herein where the device to cause such compression is composed of a fastener bar and receiver. The device has the capability to self-adjust to tissues of varying thicknesses to cause hemostasis. This tissue gap variability allows for compression of regions of tissue where thick and thin tissue are both present. This variability also enables the same device to be used on a wide variety of tissues of different thicknesses. The tissue fastener bar of this invention contains a series of cut-out portions which distribute the compressive forces along the device in an alternating, staggered manner. The receiver is of a generally U-shaped configuration with the fastener bar being contained at least partially within the U-shape. Compression occurs between the side walls of the receiver and the fastener bar and variability in gap is accomplished by flexure of the side walls of the receiver. Varying side wall flexure is enhanced by cut-out portions in the receiver which allow each segment to flex somewhat independently. A number of options also exist for configuration of the fastener bar and/or receiver with the same basic method of compression being unchanged.
Patent AU-666796-B2 (AU)
Title: Fluid-operated drive
Inventor: WEBER BRUNO
IPC: F15B15/08
Filed: 1994-01-27
Granted: 1996-02-22
Abstract: The invention relates to an actuator, in particular a pull and push actuator, which has a cylinder with a inner cylinder space (Z) and a cylinder axis (F) and a piston which is movably arranged in the cylinder and to which a flexible power-transmission means (U) is fastened. For a double-acting actuator, the inner cylinder space (Z) or the piston must have a larger cross-sectional area than the power-transmission means (U). So that the cylinder wall can nonetheless serve as a guide means for the flexible power-transmission means, either the inner cylinder space or the power-transmission means has a non-circular cross-section such that, on one cross-section, at least two points (A.1 to A.3) are obtained on which the inner cylinder wall can guide the power-transmission means. <IMAGE>
Patent AU-708111-B2 (AU)
Title: Synthetic HPV6/11 hybrid L1 DNA encoding human papillomavirus type 11 L1 protein
Inventor: HOFMANN KATHRYN J
IPC: A61K39/00
Filed: 1996-03-26
Granted: 1999-07-29
Abstract: PCT No. PCT/US96/04117 Sec. 371 Date Jan. 26, 1998 Sec. 102(e) Date Jan. 26, 1998 PCT Filed Mar. 26, 1996 PCT Pub. No. WO96/30520 PCT Pub. Date Oct. 3, 1996The present invention is directed to a synthetic DNA molecule encoding purified human papillomavirus type 11 L1 protein and derivatives thereof.
Patent AU-706104-B2 (AU)
Title: Method for introducing and expressing genes in animal cells
Inventor: POWELL ROBERT J
IPC: C12N15/87
Filed: 1996-04-24
Granted: 1999-06-10
Abstract: A method for introducing and expressing genes in animal cells is disclosed comprising infecting said animal cells with live invasive bacteria, wherein said bacteria contain a eukaryotic expression cassette encoding said gene. The gene may encode, e.g., a vaccine antigen, an therapeutic agent, an immunoregulatory agent or a anti-sense RNA or a catalytic RNA.
Patent AU-713471-B2 (AU)
Title: Ligand for receptor activator of NF-kappa B, ligand is member of TNF superfamily
Inventor: ANDERSON DIRK M
IPC: C12N15/11
Filed: 1997-12-22
Granted: 1999-12-02
Abstract: Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.
Patent AU-670481-B2 (AU)
Title: Solid form xerostomia product
Inventor: NAPOLITANO NEIL J
IPC: A61K8/86
Filed: 1994-02-24
Granted: 1996-07-18
Abstract: A solid dosage form for relieving xerostomia symptoms comprises a lubricating polymer comprising polyethylene oxide and a sialogogue in a pharmaceutically acceptable, substantially non-cariogenic, carrier.
Patent AU-664816-B2 (AU)
Title: CD package comprising non-plastic panels
Inventor: O'BRIEN PATRICK J
IPC: G11B33/04
Filed: 1994-02-28
Granted: 1995-11-30
Abstract: A storage package for a recording medium has a plurality of non-plastic panels (22a,22b,28a) and a holder (14) formed of plastic disposed on one of the panels (22b) for receiving and maintaining a recording medium thereon. At least one panel (22a,28a) is configured and dimensioned to removably receive printed matter therein. The one panel (22b) additionally defines at least one lateral spine (80) visible when the plurality of panels is in a collapsed orientation. The holder (14) is releasably secured to the one panel (22b) and easily removable therefrom. <IMAGE>
Patent AU-585056-B2 (AU)
Title: Polyamines and a process for their production
Inventor: RASSHOFER WERNER
IPC: C07C209/62
Filed: 1986-08-27
Granted: 1989-06-08
Abstract: Polyamines containing aromatically bound primary amino groups are prepared in a single stage process by hydrolyzing an isocyanate in the presence of a compound containing an amidine and/or guanidine group and a water-miscible, aprotic-dipolar solvent. This hydrolysis is carried out at from 20 DEG  to 210 DEG  C. with the reactants being in substantially homogeneous phase. The isocyanate starting material contains aromatically bound NCO groups and has NCO content of from 0.5 to 40 wt. %. The compound containing amidine and/or guanidine groups functions as a catalyst and is used in a quantity of at least 0.001 parts by weight for every 100 parts by weight of isocyanate. The water-miscible solvent is used in a quantity of at least 10 parts by weight for every 100 parts by weight of polyisocyanate. The polyamines thus-produced are particularly useful in the production of polyurethanes.
Patent AU-643459-B2 (AU)
Title: Polyether impression materials containing polyalkylene oxide derivatives
Inventor: ZAHLER WOLF-DIETRICH DR
IPC: A61K6/90
Filed: 1990-10-03
Granted: 1993-11-18
Abstract: A polyether impression material containing 
 
  (a) polyether, 
  (b) catalyst, 
  (c) mixing additive, and 
  (d) where appropriate customary additives, 
 is described, where components (a) and (b) are spatially separated from one another and where the mixing additive (c) is a polyalkylene oxide derivative which has a molecular weight exceeding 300 and which is chemically inert to the other components and, in particular, contains no hydroxyl groups, acidic groups, primary amino groups, ionic groups, halogen groups or polymerisable groups. The material can easily be mixed, has outstanding storage stability and does not undergo demixing even under elevated pressure.
Patent AU-601161-B2 (AU)
Title: Attenuation of sea swell effects
Inventor: BOUCHET RENE
IPC: E02B/
Filed: 1986-10-03
Granted: 1990-09-06
Abstract: PCT No. PCT/MC86/00003 Sec. 371 Date Aug. 13, 1987 Sec. 102(e) Date Aug. 13, 1987 PCT Filed Oct. 3, 1986 PCT Pub. No. WO87/02724 PCT Pub. Date May 7, 1987.A breakwater for attenuating the sea-swell effects of waves includes a bottom plate rigidly supporting and adapted to be immersed in a body of water. A generally upwardly extending solid front wall is formed at an upstream edge of the plate and an upper end of the front wall extends above the surface of the body of water. A generally upwardly extending rear wall is formed at a downstream edge of the bottom plate and has a plurality of regularly spaced orifices formed therein. A generally upwardly extending intermediate wall is formed between the front wall and the rear wall and also includes orifices, the front wall and the intermediate wall forming therebetween an energy dissipation basin. The front wall extends above the surface of the body of water so as to prevent the passage of a sea swell above the bottom plate as long as the amplitude of the swell is average. The water between the bottom plate and the bottom surface of the body of water behaves like an inert obstacle whereby at least a portion of an incident sea swell is reflected and any swell wave transmitted downstream is of reduced amplitude.
Patent AU-676551-B2 (AU)
Title: Compound threads, fabrics provided therefrom and process to obtain them
Inventor: RODRIGUEZ ANTONIO CABALLERO
IPC: D03D15/02
Filed: 1994-06-06
Granted: 1997-03-13
Abstract: Compound threads (1) and the fabrics obtained therefrom are very inexpensive, of acceptable quality and preferably useable to make recyclable disposable garments. Said threads (1) include a thin carrier thread (2) to which a web mass (3) coming from the carding of the fiber used, is adhered preferably by means of use of a water-soluble glue or electrostatic means. The compound thread (1) has the possibility of making use, upon making the web (3), of the shortest fibrils that are usually disposed of. One of the fabrics obtained consists of a band or strip of web (3) that includes several carrier threads (2) placed parallel to each other and that can be cut to obtain compound threads (1.) Another fabric consists of weft thread and crossed warp thread of which all or some, depending on the different combinations, are compound threads (1.) <IMAGE>
Patent AU-672699-B2 (AU)
Title: Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses
Inventor: YOSHIDA AKIRA
IPC: C07C233/25
Filed: 1994-06-28
Granted: 1996-10-10
Abstract: Compounds of formula (I): <CHEM> in which: R<1> is alkyl or a group of formula (II), (III), (IV) or (V): <CHEM>   <CHEM> and in which the groups R<2>, R<3>, R<4> and R<5> are hydrogen or various organic groups; and pharmaceutically acceptable salts thereof are useful in the treatment and prophylaxis of hypercholesteremia and arteriosclerosis; methods for the preparation of such compounds are also provided.
Patent AU-539617-B2 (AU)
Title: Methylated anilines
Inventor: HAUSBERG HANS-HEINRICH
IPC: C07D317/66
Filed: 1981-01-07
Granted: 1984-10-11
Abstract: 1. Aniline derivatives of the general formula I  see diagramm : EP0031910,P14,F5  wherein Ar is phenyl or a phenyl group which is substituted by F, CI, alkoxy with up to 4 C atoms, methylenedioxy, OH, trimethylene or CF3 , R is -CH(C6 H5 )-CH2 CH2 -N(CH3 )-Z or 2-(1-methyl-2-piperidyl)-ethyl and Z is H or methyl, and physiologically acceptable acid addition salts thereof.
Patent AU-714801-B2 (AU)
Title: Process for the production of an aqueous solution of a tertiary amine-oxide
Inventor: MANNER JOHANN
IPC: D01F2/00
Filed: 1996-08-16
Granted: 2000-01-13
Abstract: The invention relates to a process for producing an aqueous amine oxide solution used in the amine oxide process for producing a mouldable cellulose solution, in which aqueous amine oxide-containing solutions occurring in the amine oxide process especially as regenerating baths are purified and concentrated, where a microbicidal agent is added to the aqueous amine oxide-containing solutions before, during or after purification.
Patent AU-785353-B2 (AU)
Title: Method and system for predicting therapeutic agent resistance and for defining the genetic basis of drug resistance using neural networks
Inventor: LARDER BRENDAN
IPC: G16H70/20
Filed: 2001-06-01
Granted: 2007-02-01
Abstract: A method and system for predicting the resistance of a disease to a therapeutic agent is provided. Further provided is a method and system for designing a therapeutic treatment agent for a patient afflicted with a disease. Specifically, the methods use a trained neural network to interpret genotypic information obtained from the disease. The trained neural network is trained using a database of known or determined genotypic mutations that are correlated with phenotypic therapeutic agent resistance. The present invention also provides methods and systems for predicting the probability of a patient developing a genetic disease. A trained neural network for making such predictions is also provided. Also provided is a method and system for determining the genetic basis of therapeutic agent resistance.