baber/WOPTO huggingface dataset:
Patent NZ-324775-A (NZ)
Title: 17-side chain alkynyl-and 20-oxopregna-derivatives of vitamin d, methods for their production and pharmaceutical compositions thereof
Inventor: HESSE ROBERT HENRY
IPC: C07C401/00
Filed: 1996-12-23
Abstract: 1-Hydroxy pregnacalciferol derivatives of formula (I) and their corresponding 5,6-trans isomers wherein R1 is hydroxyl or lower alkoxy and R2 is optionally hydroxylated or lower alkoxylated lower alkynyl or R1 is C(RA) (RB)CH3 where RA is optionally hydroxylated or lower alkoxylated lower alkynyl and RB is hydroxyl or lower alkoxy or RA and RB together represent oxo and R2 is hydrogen, hydroxyl or lower alkoxy, and R3 and R4 represent hydrogen atoms, exhibit anti-progesterone activity and may be useful as antineoplastic, antifertility, antiproliferative, immunosuppressive and/or antiinflammatory agents.
Patent NZ-332838-A (NZ)
Title: Filler for use in paper manufacture containing pigment and noil produced from cellulosic/mechanical pulp fibre
Inventor: SILENIUS PETRI
IPC: D21H17/69
Filed: 1998-11-18
Abstract: The specification describes a filler for use in paper manufacture. The filler contains pigment and noil produced from cellulose fibre and/or mechanical pulp fibre.  The noil is characterised by the fact that the noil fibrils correspond in size distribution to a wire screen fraction P50 and preferably P100.  The filler is reported to enable the production of high quality paper using a reduced amount of raw material.
Patent NZ-334673-A (NZ)
Title: Injectable formulations of avermectins and milbemycins
Inventor: GROSSE-BLEY MICHAEL
IPC: A61K47/44
Filed: 1997-09-08
Abstract: Injectable formulations of avermectins and milbemycins based on a solvent mixture which contains sesame seed oil, medium-chain triglycerides, glycol esters or fatty acid esters and another solvent of the series of monovalent or polyvalent aliphatic or aromatic alcohols and their derivatives (for example cyclic carbonates, acetates, acetals and ketals) or castor oil.
Patent NZ-335991-A (NZ)
Title: Application of shear flow stress to chondrocytes with a bioreactor to produce artificial cartilage
Inventor: SELIKTAR DROR
IPC: C12N11/02
Filed: 1997-11-18
Abstract: A bioreactor and method are provided for application of shear flow stress of 1 to 100 dynes/cm2 to cultured mammalian cells used for production of artificial cartilage. The bioreactor is a circulating flow system (16) containing a media reservoir (9), a pump (10), a growth chamber (11) containing a substrate such as a mono-layer supporting surface or a 3-dimensional scaffold, and tubing (12). Shear flow stress can be applied by growing a chondrocyte monolayer on the surface of a rotating drum or rotating disc immersed in liquid growth medium, by growing a chondrocyte monolayer on static plates past which a liquid growth medium is pumped, or by establishing chondrocytes in a 3-dimensional scafold and pumping liquid growth medium through the scaffold.  Application of flow shear stress increases the ratio of type II to type I cartilage produced by cultured chondrocytes, and enhances maintenance of chondrocyte phenotype.
Patent NZ-336990-A (NZ)
Title: Aqueous suspension for nasal administration comprising loteprednol and microcrystalline cellulose carmellose sodium
Inventor: DOI KOJI
IPC: A61K9/00
Filed: 1998-01-14
Abstract: Long-term stabilisation of aqueous suspension of loteprednol etabonate having anti-inflammatory and anti-allergic activities with microcrystalline cellulose carmellose sodium for use as nasal drops. The suspension is further characterised by higher intranasal retention without dermal or mucosal irritation.
Patent NZ-503835-A (NZ)
Title: Air treatment apparatus and system with mineral filter
Inventor: MAHER ANTHONY JAMES
IPC: B01J20/02
Filed: 2000-04-07
Abstract: An air filtering system (100) comprising a chamber (101), a closure head (102), a filter element (105) suspended in the chamber (101) and an air inlet (103) and outlet (104) to the chamber (101). The filter element (105) is a solid mineral element composed of one or more of calcium phosphate, calcium sulphate, and calcium carbonate and/or iron ore.
Patent NZ-506363-A (NZ)
Title: Mechanical system for propelling a slingshot or amusement device
Inventor: MIRFIN BRIAN
IPC: A63G31/00
Filed: 1999-03-18
Abstract: An amusement device, such as a sling-shot machine, for successively propelling and retarding a rider to cause the rider to undergo a vertically oscillatory motion.  The amusement device comprises cables (31, 32) one end of each of which is connected to a carrier (19) for supporting one or more riders.   A releasable anchoring means is provided for releasably anchoring the carrier (19) at a launch site (17).   An elastic structure (71) has opposed ends between which the elastic structure can undergo extension and contraction. One end of the elastic structure (71) is connected to a first support means (57).  Each cable (31, 32) passes around a support tower (11) and has a section thereof winding back and forth between first and second guide means (83, 85).  The first guide means (83) is connected to the other end of the elastic structure (71) and the second guide means (85) is connected to a second support means (47).  The winding section of the cable (31, 32) provides a link between the elastic structure (71) and the second support means (47).  A hydraulic ram (67) is provided for tensioning the elastic structure (71) prior to release of the anchoring means whereby energy stored in the loaded elastic structure (71) is transferred to the cables (31, 32) to cause upward propulsion of the carrier (19) on release of the anchoring means.
Patent NZ-507141-A (NZ)
Title: Quinolin-4-yl derivatives I and their use in treating neurodegenerative disease
Inventor: JAESCHKE GEORG
IPC: C07D401/12
Filed: 2000-09-26
Abstract: Described are compounds of the formula as shown, wherein: R1 is hydrogen, lower alkyl, lower alkoxy, hydroxy, amino, nitro, cyano, lower alkyl-amino, di-lower alkyl-amino or halogen; R2 is phenyl, optionally substituted by lower alkyl, lower alkoxy, halogen, trifluoromethyl, amino, lower alkyl-amino or di-lower alkyl-amino, 2,3-dihydro-benzofuran-5-yl, chroman-6-yl, napthalen-2-yl, indan-5-yl, lower alkenyl-phenyl, 5,6,7,8-tetrahydro-napthalenyl, 2,3-dihydro-isoindol-2-yl,1,2,3,4-tetrahydro-napthalenyl, benzofuran-2-yl, benzo[b]thiophen-2-yl, lower alkyl-phenyl, 3,4-dihydro-1H-isoquinolin-2-yl or thiophen-3-yl; R3 and R4 are independently from each other hydrogen or lower alkyl; R5  is hydrogen, lower alkyl, - CH2OH or CH2NR2R7; R6 and R7 are independently form each other hydrogen, lower alkyl, -(CH2)n-phenyl, cycloalkyl,-(CH2)m-morpholinyl or form together with the N-atom a saturated ring with 4-6 C-atoms; n is 0 - 3; m is 2 or 3; N is -NR8 - or -O-; or X and R5 are together >N(CH2)2-; or X and R3 are together >N(CH2)3-; and R8 is hydrogen or lower alkyl; and to pharmaceutically acceptable acid addition salts thereof, with the exception of the following compounds: (6-chloro-2-phenyl-4-quinolinyl)-(+)-2-aminobutanol; (6-methyl-2-phenyl-4-quinolinyl)-(+)-2-aminobutanol; (6-methoxy-2-phenyl-4-quinolinyl)-(+)-2-aminobutanol; and (8-methoxy-2-phenyl-4-quinolinyl)-(+)-2-aminobutanol. Also described is the use of a compound in the manufacture of a medicament for the treatment of diseases based on therapeutic indications for NMDA receptor subtype specific blockers, which include acute forms of neurodegeneration caused e.g, by stroke and brain trauma.  Included are chronic forms of neurodegeneration such as Alzheimer's disease, Parkinson's disease, Huntington's disease, ALS (amyotrophic lateral sclerosis) and neurodegeneration associated with bacterial or viral infection, and chronic or acute pain.
Patent NZ-511619-A (NZ)
Title: Imidazo[4,5-b]pyridiniummethyl-containing cephem compounds, pharmaceuticals thereof and their use as broad spectrum antibacterials
Inventor: NISHITANI YASUHIRO
IPC: C07D501/56
Filed: 1999-11-25
Abstract: The compound of formula (I) where: X is N or CY and Y is H or halogen R1 is amino or protected amino R2 is hydrogen, hydroxy, halogen, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkylthio or optionally substituted amino R4 is hydrogen, hydroxy, substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted cycloalkyl, optionally substituted cycloalkyl(lower)alkyl or an optionally substituted N-containing heterocylic group R5 is hydrogen, amino, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkylthio or R4 and R5 taken together may form lower alkylene in which an optional hetero atom(s) intervene and a wavy line means syn- or anti-isomerism or a mixture thereof, an ester, a pharmaceutically acceptable salt, a prodrug, or a solvate thereof. Also described are pharmaceutical compounds comprising the compound of formula (I). The compounds of formula (I) are useful as bacterial agents and show antibacterial activity against gram-positive bacteria including MRSA and gram-negative bacteria. The method for preparing the compound of formula (I) comprises reacting a compound of formula (V), wherein R6 is a leaving group and the other symbols are as defined above, with a compound of the formula (IV) wherein R3, R4 and R5 are as defined above, followed by optional deprotection. Also described is a compound of formula (IV) wherein R3 is hydrogen, R4 is -(CH2)3NHCH3 and R5 is hydrogen.
Patent NZ-512569-A (NZ)
Title: Method for reducing frictional losses in tunnels
Inventor: JACOBSEN TOM
IPC: F16L1/00
Filed: 1999-12-13
Abstract: Method for reducing frictional loss in unlined tunnels (6) or other tunnels with a rough wall surface and/or irregular cross section.  A flexible or rigid pipe (1) with a cross section (5) similar to or somewhat less than the largest circularly open cross section of the tunnel is introduced into the tunnel and attached continuously or at certain points (2) to parts of the tunnel wall (6).  Means ensuring that a superpressure occurs within the pipe (1) relative to its outside during flow are also introduced.
Patent NZ-512859-A (NZ)
Title: Combination chemotherapy
Inventor: GOWAN RICHARD CARLETON
IPC: A61K31/4453
Filed: 1999-12-21
Abstract: An anticancer combination which comprises a mitotic inhibitor (such as paclitaxel, docetaxel, vincristine, vinblastine, vinorelbine, and vinflunine) and a MEK inhibitor for treating cancer. The MEK inhibitor is a phenyl amine compound of Formula I where: R1 is hydrogen, hydroxy, C1-C8 alkyl, C1-C8 alkoxy, halo, trifluoromethyl, or CN; R2 is hydrogen; R3, R4, and R5 independently are hydrogen, hydroxy, halo, trifluoromethyl, C1-C8 alkyl, C1-C8 alkoxy, nitro, CN, or -(O or NH)m- (CH2)n-R9, where R9 is hydrogen, hydroxy, COOH, or NR10R11 ; n is 0-4; m is 0 or 1; R10 and R11 independently are hydrogen or C1-C8 alkyl, or taken together with the nitrogen to which they are attached can complete a 3-10 member cyclic ring optionally containing 1,2, or 3 additional heteroatoms selected from O, S, NH, or N-C1-C8 alkyl; Z is COOR7, tetrazolyl,CONR6R7, CONHNR10R11, or CH2OR7; R6 and R7 independently are hydrogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, (CO)-C1-C8 alkyl, aryl, heteroaryl, or C3-C10(cycloalkyl optionally containing 1, 2, or 3 heteroatoms selected from O, S, NH, or N alkyl); and where any of the foregoing alkyl, alkenyl, aryl, heteroaryl, heterocyclic and alkynyl groups can be unsubstituted or substituted by halo, hydroxy, C1-6 alkoxy, amino, nitro, C1-4 alkylamino, di(C1-4)alkylamino, C3-6 cycloalkyl, phenyl, phenoxy, C3-5 heteroaryl or heterocyclic radical, or C3-5 heteroaryloxy or heterocyclic radical-oxy. The MEK inhibitor may also be the compound 2- (2-amino-3-methoxyphenyl)-4-oxo-4H-[l](2-amino-3-methoxyphenyl)-4-oxo-4H-[l] benzopyran.
Patent NZ-513298-A (NZ)
Title: C7 ester substituted taxol derivatives useful for inhibiting tumour growth
Inventor: HOLTON ROBERT A
IPC: A61K31/341
Filed: 2001-08-01
Abstract: A taxane having the structure shown in formula (I) is described wherein: R2 is acyloxy; R7 is R7aCOO-; R7a is hydrocarbyl, substituted hydrocarbyl or heterocycle, where hydrocarbyl or substituted hydrocarbyl contains carbon atoms in the alpha and beta positions relative to the carbon atom of which R7a is a substituent and wherein, said substituted hydrocarbyl is substituted with a group selected from halogen heterocycle, alkoxy, alkenoxy, alkynoxy, aryloxy, hydroxy, protected hydroxy, acyloxy, nitro, cyano, thiol, ketals, acetals, and ethers. R9 is keto, hydroxy or acyloxy; R10 is hydroxy; R14 is hydrido or hydroxy; X3 is substituted or unsubstituted alkyl, alkenyl, alkynyl, or heterocycle; X5 is -COX10, -COOX10, or CONHX10; X10 is hydrocarbyl, substituted hydrocarbyl, or heterocyclo; and Ac is acetyl. The taxane can be used in the manufacture of a pharmaceutical composition for inhibiting tumor growth.
Patent NZ-513908-A (NZ)
Title: A gel free detection system comprising at least one probe for detecting a splicing reaction
Inventor: HULS CHRISTOPH
IPC: C12Q1/6883
Filed: 2000-02-25
Abstract: Described is a test system comprising: (a) one or more identical or different immobilized nucleic acids including at least one nucleic acid capable of splicing; (b) at least one gel-free detection system for detecting a splicing reaction; possibly (c) at least one compound containing splicing components; and preferably (d) suitable detection probes.
Patent NZ-516417-A (NZ)
Title: High molecular weight zwitterionic polymers
Inventor: CARTER PHILLIP W
IPC: C08F218/08
Filed: 2000-06-28
Abstract: This  invention is directed to high  molecular  weight water-soluble    zwitterionic    polymers    derived    from zwitterionic and nonionic monomer units, and to the  use  of the polymers in papermaking processes.
Patent NZ-516668-A (NZ)
Title: Characterization of the contact distribution between two arbitrary surfaces using electrode arrays
Inventor: SAVARD PIERRE
IPC: A61B5/296
Filed: 2000-07-28
Abstract: A method of characterisation of the temporal and spatial evolution of contact between two arbitrary surfaces using electrical signals measured by arrays of electrodes; comprises: a) applying a probe surface containing arrays of electrodes against a specimen surface causing the electrodes to generate signals in response to the specimen surface; b) obtaining the signals from electrodes; c) analyzing the signals to estimate amplitude and velocity of a displacement applied on specimen surface over time and angular orientation of probe surface. Apparatus for diagnosing a tissue condition; comprises: a) a probe having a tip; b) electrode arrays on the tip; c) signal acquisition and processing means for detecting the condition of a tissue using electrical potentials induced by compression of the tested tissue against a probe surface containing exposed electrodes.
Patent NZ-520076-A (NZ)
Title: Expression and secretion vector for human interferon alpha and process for producing human interferon alpha by employing same
Inventor: KWON SE-CHANG
IPC: C07K14/245
Filed: 2001-01-19
Abstract: Disclosed are: an expression vector for the secretive production of human interferon alpha (hIFNá) comprising a polynucleotide encoding a modified E. coli thermostable enterotoxin II signal sequence and a polynucleotide encoding hIFNá) ligated to the 3'-end thereof; a microorganism transformed with the expression vector; and a process for secretively producing human interferon by culturing the microorganism, said process being capable of secreting a soluble form of active hIFNá), which does not contain an additional methionine residue at its N-terminal, into the periplasm of an E. coli cell.
Patent NZ-520284-A (NZ)
Title: Modulation by chirp signals, in particular for application in a multi-path environment
Inventor: BANNASCH RUDOLF
IPC: H04B1/69
Filed: 2000-12-20
Abstract: A method for transmitting and receiving information by means of waves, comprising: (a) an information signal is attached to a carrier wave, whose frequency is continuously changed to form a series of at least two carrier sweeps in a preset time interval, (b) the carrier wave is transmitted as a transmission signal without transmission of a reference signal, (c) the frequency characteristic of the carrier sweeps is varied with respect to at least one of the frequency position of the carrier sweeps, the rise of the carrier sweeps and the form of the change in the carrier frequency from carrier sweep to carrier sweep, and (d) the transmission signal is filtered after being received in the frequency range for separating multipath components or is cleaned of noise portions and is evaluated from itself with respect to information-carrying signal parameters. Also disclosed are sending and receiving devices adapted for transmitting and receiving information of the above method.
Patent NZ-520910-A (NZ)
Title: Hydrochloride salts of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione
Inventor: CRAIG ANDREW SIMON
IPC: A61P3/10
Filed: 2001-03-14
Abstract: A substantially non-hydrated and non-hygroscopic or slightly hygroscopic hydrochloride salt of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione. The use of the above described compound and other disclosed for treatment and or prophylaxis of diabetes mellitus and associated conditions. A process for the manufacture of the above described compound is also disclosed.
Patent NZ-526107-A (NZ)
Title: Object tracking and management system and method using radio-frequency identification tags
Inventor: FRANCIS ROBERT C
IPC: B65G1/137
Filed: 2001-04-20
Abstract: A tracking system (100) for tracking an object (132) positionable at a plurality of locations, the system comprises:- (a) A transport vehicle (110) to move the object between locations; (b) An object marker (130) associated with the object that stores information indicating the identity of the object; (c) A plurality of location markers (140,150) positioned at different locations and storing information indicating the location of the marker; (d) At least one interrogator (120) mounted on a vehicle to receive from the object marker the information indicating the identity of the object and from the location markers information on the location of the markers, the interrogator is comprised of at least one radio-frequency transmitter for transmitting information to be stored on a marker and at least one radio-frequency receiver; and (e) A processor on-board (160) the vehicle operatively connected to the interrogator, the processor determines the identity of the object from; the information indicative of the identity of the object; the location of at least one of the location markers from the information indicative of the location of the marker; and the spatial relationship between the object and the location.
Patent NZ-526149-A (NZ)
Title: Separated pocket spring mattress
Inventor: AHLQUIST ROBERT
IPC: B68G9/00
Filed: 2001-11-23
Abstract: A spring mattress comprising a plurality of interconnected coil springs (1) enclosed in covers (2), known as a pocket-spring mattress, is described, wherein at least two springs that are located adjacent to one another are spaced apart by an interjacent separation distance (SA), said separation distance exceeding approximately 10 % of the diameter of the largest one of the spiral turns of the adjacent springs. Also described is a method of manufacturing a corresponding mattress.
Patent NZ-527145-A (NZ)
Title: Novel carotenoid esters
Inventor: BINNINGTON RICHARD H
IPC: C11B1/00
Filed: 2002-02-22
Abstract: Described are mono-, di-, and poly- esters comprising at least one alcohol-derived moiety and at least one acid-derived moiety, wherein the at least one alcohol-derived moiety comprises a hydroxy carotenoid selected from the group consisting of monohydroxy carotenoids, dihydroxy carotenoids, and polyhydroxy carotenoids, and wherein the at least one acid-derived moiety comprises a carboxylic carotenoid selected from the group consisting of monocarboxylic carotenoids, dicarboxylic carotenoids, and polycarboxylic carotenoids. The synthetic ester linkage between two or more carotenoids provides new compounds in which the similar and complimentary processes of the carotenoids are combined; the all-carotenoid esters may be useful as antioxidants, therapeutic agents or pigmenting agents; the polyesters have to potential to act as molecular wires with unique electrical conductance characteristics.
Patent NZ-527574-A (NZ)
Title: Game of creativity to teach players to problem solving and opportunity answering
Inventor: D CRUZ DAMIAN CRAIG
IPC: A63F3/00
Filed: 2003-08-12
Abstract: A board game played by two or more players, is intended to teach the players to solve problems and address opportunities through collective and individual responsibility, wherein the players work as a team rather than individuals. The board game includes: a game board having marked thereon a playing track, the track being divided into four sides and four corner spaces, each the side consisting of sequential spaces, each the side being distinctly labelled; a distinct game token for the team, which is moved along the track; a plurality of cards to be shared by all players of the board game and to be drawn by the team, the cards marked with indicia, and comprising a first set of "define" cards; a second set of "explore" cards; a third set of "innovate" cards; a fourth set of "incubate" cards; a fifth set of "quote" cards; a sixth set of "random" cards; one or more dice rolled by players to obtain an indication of how they should move their token on the track; and the side on which the team token is located directing which sub-set of cards a player must draw from. The track can contain spaces marked to instruct the players to pick up a the random card or a the opportunity card along with the card for the side of the track when the token lands in the space.
Patent NZ-528517-A (NZ)
Title: Benzamidine derivative
Inventor: FUJIMOTO KOICHI
IPC: A61P9/10
Filed: 2002-04-03
Abstract: Disclosed herein are benzamidine derivatives of formula (I) and their pharmacologically acceptable salts, wherein R1 is a hydrogen atom, a halogen atom, an C1-6alkyl group or a hydroxyl group; R2 is a hydrogen atom or a halogen atom; R3 is an C1-6alkyl group substituted with a hydroxyl group, an C3-13alkoxycarbonylalkylsulfonyl or C2-7carbonylalkylsulfonyl; R4 and R5 are the same or different and each of R4 and R5 is a hydrogen atom, a halogen atom, a C1-6alkyl group, a C1-6alkyl group substituted with a halogen atom, a C1-6alkoxy group, a C2-7alkoxycarbonyl group, a carbamoyl group, a C2-7monoalkylcarbamoyl group or a C3-13dialkylcarbamoyl group; R6 is a hydrogen atom, a C1-6alkyl group, a C3-8cycloalkyl group, a C7-16aralkyl group, a C1-6alkyl group substituted with a heterocycle, a C2-7carboxyalkyl group, a C3-13alkoxycarbonylalkyl group, a C2-7aliphatic acyl group, a C7-11aromatic acyl group, a carbamoyl group, a C1-6alkylsulfonyl group, an C6-10aryl group, a heterocycle, a formimidoyl group, a C3-71-iminoalkyl group, an C2-7N-alkylformimidoyl group or an C7-11iminoarylmethyl group; each of R7 and R8 is a hydrogen atom or an C1-6alkyl group; or R6 and R7 taken together or R7 and R8 taken together form an C2-5alkylene group; and n represents 0, 1 or 2. These benzamidine derivatives and the salts have excellent inhibition action for activated blood coagulation factor X, and are useful as a medicine for therapy or prevention of a disease of blood coagulation.