baber/WOPTO huggingface dataset:
Patent NZ-614787-A (NZ)
Title: Crystalline forms and processes for the preparation of condensed azacycles ( cannabinoid receptor modulators)
Inventor: BLACKBURN ANTHONY C
IPC: A61K31/416
Filed: 2012-02-24
Abstract: Disclosed are anhydrous crystalline forms of condensed azacycles with pyrazole and pyrazine components, and a process for preparing the compounds by crystallising from acetonitrile and water, and other non-selective solvates. The anhydrous crystalline form of (1aS,5aS)-2-(4-oxy-pyrazin-2-yl)-1a,2,5.5a-tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid ((S)-1 -hydroxymethyl-2,2-dimethyl-propyl)-amide (Compound 1) and pharmaceutical compositions thereof are disclosed which modulate the activity of the cannabinoid CB receptor and are therefore useful in the treatment of CB receptor-mediated disorders, for example, osteoarthritis; pain; hyperalgesia; allodynia; inflammatory hyperalgesia; neuropathic hyperalgesia; acute nociception; osteoporosis; multiple sclerosis-associated spasticity; autoimmune disorders; allergic reactions CNS inflammation for example; atherosclerosis; undesired immune cell activity, and inflammation associated with a disorder selected from: osteoarthritis, anaphylaxis, Behcet’s disease, graft rejection, vasculitis, gout, spondylitis, viral disease, bacterial disease, lupus, inflammatory bowel disease, autoimmune hepatitis, and type 1 diabetes mellitus; age-related macular degeneration; cough; leukaemia; lymphoma; CNS rumours; prostate cancer; Alzheimer’s disease; stroke-induced damage; dementia; amyotrophic lateral sclerosis; and Parkinson’s disease.
Patent NZ-617573-A (NZ)
Title: Composition comprising aflibercept, folinic acid, 5-fluorouracil (5-fu) and irinocetan (folfiri)
Inventor: CASTAN RÉMI
IPC: A61P35/00
Filed: 2012-04-25
Abstract: Pharmaceutical composition comprising aflibercept, folinic acid, 5-fluorouracil (5-FU) and irinocetan (FOLFIRI) useful in the treatment of Colorectal cancer (CRC).
Patent NZ-625144-A (NZ)
Title: Heat recovery system
Inventor: REECE CARL LLOYD
IPC: F28F21/06
Filed: 2013-03-18
Abstract: A heat exchanger 2 comprises a housing 13 comprising an exhaust air inlet 14, an exhaust air outlet 15, a supply inlet and a supply outlet, and a plurality of panels located within the housing. The panels are spaced apart from each other so as to form a plurality of first channels extending through the heat exchanger in a first direction A. Each panel comprises substantially parallel walls separated by a plurality of spacers so as to form a plurality of second channels extending through each panel in a second direction B. Spaces between the panels in the second direction B are closed. The housing 13 is formed of a corrosion resistant plastics material. Joints between the panels and the housing are sealed with vinyl ester resin, and the arrangement of the panels is such that supply air is in thermal communication with exhaust air.
Patent NZ-700054-A (NZ)
Title: Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same
Inventor: CHEN ROGER SHEN-CHU
IPC: C07D495/04
Filed: 2011-02-10
Abstract: Disclosed herein is a compound of formula (II) or (III), wherein the variables are defined in the specification, and the use thereof in the treatment of cancer, a disorder associated with angiogenesis, pain, macular degeneration or a related syndrome, a skin disease, a pulmonary disorder, an asbestos-related disorder, a parasitic disease, an immunodeficiency disorder, a CNS disorder, CNS injury, atherosclerosis or a related disorder, dysfunctional sleep or a related disorder, an infectious disease, hemoglobinopathy or a related disorder or a TNFα related disorder. In one embodiment the compound is 3-(4-(4-(2-morpholinoethoxy)-benzyloxy)-1-oxoisoindolin-2-yl)-piperidine-2,6-dione.
Patent NZ-707065-A (NZ)
Title: Apparatus and method for applying colors and performance chemicals on carpet yarns
Inventor: TUNG WAE-HAI
IPC: D06M15/643
Filed: 2013-09-18
Abstract: Disclosed are processes for application of dyes and topical chemistries to single yarns during a yarn rewind process. The process foregoes the need for downstream environmentally unfavorable dyeing and low PH chemical treatment processes on the finished carpet. Further, neutral pH dye solutions can be used instead of the prior art low pH dye solutions. The single, treated yarn can then be twisted, weaved and tufted, twisted yarn under dry conditions, and the twisted yarn subsequently weaved or weaved and tufted, into a finished fabric or carpet. Also disclosed are systems, BCF yarns, and carpets made from the BCF yarn treated by the disclosed processes.
Patent NZ-709993-A (NZ)
Title: Novel fortified food products and their method of use
Inventor: RICCARDO SIGNOR
IPC: A61P1/00
Filed: 2015-07-14
Abstract: There is a need to develop new types of functional foods that improve digestive health and well-being. The present application provides a new fortified yogurt composition with both an extract from an Artemisia absinthium plant; and an extract from an Achillea millefolium plant. The fortified yogurt had a surprising beneficial flavour profile, a heightened stability and shelf life, and preliminary data which supports improvements in digestive health.
Patent NZ-712617-A (NZ)
Title: Bacterium belonging to genus lactobacillus
Inventor: FUKUSHIMA EIJI
IPC: C12R1/225
Filed: 2014-04-16
Abstract: Provided is a Lactobacillus pentosus strain TUA4337L (Accession No. NITE BP-1479) that is characterized by having the ability to propagate in the small intestine and/or the large intestine, preferably in the small intestine, after reaching the intestinal tract. As a result of the lactic acid bacterium of the present invention having the ability to propagate in the intestinal tract, said lactic acid bacterium reaches the intestinal tract and propagates when ingested, is therefore capable of continuously minimizing the absorption of fat and effectively minimizing weight gain, and can thus be suitably used for the purpose of achieving a diet effect.
Patent NZ-716182-A (NZ)
Title: Methods for controlling fucosylation levels in proteins
Inventor: NAIR PRADIP
IPC: C12N5/00
Filed: 2014-07-23
Abstract: The present invention relates to a method or process for controlling, inhibiting or reducing protein fucosylation in a eukaryote and/or a eukaryotic protein expression system. Said method comprises carrying out the protein expression and/or post-translational modification in the presence of an elevated total concentration of manganese or manganese ions. In particular, the present invention relates to a method for decreasing fucosylation and increasing levels of Man 5, asialo, agalacto biatennary complex N-glycan (G0) in a eukaryotic protein expression system comprising mammalian cells in a culture medium and in the presence of an elevated total concentration of manganese or manganese ions, wherein the elevated concentration of manganese or manganese ion in the culture medium is in the range of ≥ 0.075 mM - ≤ 0.5 mM and wherein the expressed immunoligand has a reduced degree of fucosylation and increased levels of G(0) compared to an immunoligand expressed in the absence of an elevated concentration of manganese or manganese ions.
Patent NZ-723150-A (NZ)
Title: Treatment of neoplasia
Inventor: CADE DAVID
IPC: A61P35/00
Filed: 2015-01-23
Abstract: A method of treating cancer in a patient comprising administering to the patient an a systemic chemotherapeutic drug regime comprising oxaliplatin (OXA), leucovorin (LV) and 5-fluorouracil (5-FU), in combination with a selective internal radiation therapy (SIRT), characterised in that the two therapies when introduced into the patient have an improved anticancer effect.
Patent NZ-724287-A (NZ)
Title: Application of ultrasound in vinification processes
Inventor: INIESTA ORTIZ JUAN ALBERTO
IPC: C12G1/02
Filed: 2015-02-25
Abstract: The present invention refers to a method for the extraction of compounds from grapes by means of ultrasound in vinification processes generated through a sonoplate coupled to the walls of the pipe/duct through which the crushed grapes flow. The presence of sonoplates reduce the heat produced during the ultrasound treatment, avoiding the formation of hydroxymethylfurfural (HMF). HMF has been related to harmful effects on health, such as colon cancer, nephrotoxic processes and chromosomal aberrations. During the extraction, the transfer of phenols responsible for color from the solid portion (skin) to the liquid portion after crushing the grapes takes place as a consequence of the phenomenon known as cavitation, which allows the breaking of the skin cells and makes the phenolic compounds responsible for the color available to the liquid medium to be integrated in said liquid medium enhancing wine color.
Patent NZ-724544-A (NZ)
Title: Treatment of brain cancer
Inventor: LEE PATRICE
IPC: A61K45/06
Filed: 2013-03-25
Abstract: Disclosed is the use of N4-(4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine in the manufacture of a medicament for treating local or metastatic brain cancer that is caused by ErbB2 over-expression or amplification, wherein the medicament comprises an amorphous solid dispersion comprising amorphous N4-(4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine, and wherein the amorphous solid dispersion is used after previous treatment for breast or brain cancer.
Patent NZ-728556-A (NZ)
Title: Carton with reinforced handle
Inventor: HOLLEY JOHN
IPC: B65D5/468
Filed: 2015-08-18
Abstract: For convenience, articles such as containers, bottles and cans are often transported in cartons. Existing cartons range in material and configuration, and often offer minimal or complex protection to the articles, or inconvenient carrying mechanisms. The present invention addresses these issues by providing cartons with article protection flaps and inserts which are relatively simpler to assemble and which offer better means of protecting the articles, and allowing for the carton to be carried more conveniently. In this respect the present invention provides a carton for holding a plurality of articles, the carton comprising: a plurality of panels that extends at least partially around an interior of the carton, the plurality of panels comprising at least a top panel and a side panel; a plurality of end flaps respectively foldably connected to respective panels of the plurality of panels, the plurality of end flaps being at least partially overlapped with respect to one another to thereby at least partially form a closed end of the carton, the plurality of end flaps comprising at least a side end flap foldably connected to the side panel along a first fold line; a handle in the closed end of the carton for grasping and carrying the carton, the handle extending in at least the side end flap; and a reinforcing flap foldably connected to the side end flap along a second fold line, the reinforcing flap at least partially overlapping the side end flap for reinforcing the handle, a portion of the side end flap having a free edge that is collinear with the second fold line, the free edge of the side end flap extends below the lower edge of the reinforcing flap and is parallel to the second fold line, the handle comprises a first opening in the side end flap and a second opening in the reinforcing flap, and the first opening and the second opening are generally aligned with one another in the closed end, and the side end flap comprises an upper edge and a lower edge opposite the upper edge and the second fold line extends from the upper edge and the lower edge, and the second fold line is interrupted by the first opening and the second opening so that the second fold line extends generally upwardly and downwardly from the first opening and the second opening. The configuration of the present invention with the protection flaps and insert allows for a more efficient assembly process, and provides relatively better protection to beverage containers held in the carton, along with a more robust handle. Further, the configuration of the handles provides for a more convenient and relatively safer carrying mechanism.
Patent NZ-729118-A (NZ)
Title: Dioxolane analogues of uridine for the treatment of cancer
Inventor: BETHEL RICHARD
IPC: A61P35/00
Filed: 2015-08-24
Abstract: The invention provides compounds of formula (I), wherein: R1 is OR11, or NR5R5’; R2 is H or F; R5 is H, C1-C6alkyl, OH, C(=O)R6, O(C=O)R6 or O(C=O)OR6; R5´ is H or C1-C6alkyl; R6 is C1-C6alkyl or C3-C7cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.
Patent NZ-739391-A (NZ)
Title: Orthotic device for shoes
Inventor: SALKAVICH EMILY
IPC: A43B7/24
Filed: 2016-08-05
Abstract: An orthotic device (10) for use with a heeled, dress, flat or sport shoe, the device comprising a body portion (25) comprising forefoot and midfoot portions, and a rearfoot portion having a planar surface. A medial arch support (40) is oriented at a medial side of the midfoot portion and is defined by a solid projection in the form of a curved convex prominence extending upwardly superiorly away from the planar surface body portion. A valgus wedge (20) extends continuously anteriorly from a lateral side of the rearfoot portion to a lateral side of the forefoot portion. The valgus wedge (20) is defined by a solid projection extending upwardly superiorly away from the planar surface body portion, extending continuously from a lateral rear foot portion to a lateral forefoot portion of the body, and sloping downwardly inferiorly toward the body portion from a lateral edge of the body portion toward a medial side of the body portion. The valgus wedge is adapted to evert a user’s foot and concentrate the support of the device laterally. In a longitudinal mid region in the midfoot portion of the body portion, the valgus wedge and the medial arch support define first and second high points with a depression located in between the high points. The rearfoot support portion of the device is planar from a medial edge to the lateral edge of the rearfoot portion. Due to the “windlass mechanism”, existing orthotic support designs are not suitable for heel users as they place emphasis on medial arch support which will amplify over-supination. The disclosed orthotic support increases the valgus wedge support in conjunction with medial arch support to overcome these issues.
Patent NZ-739853-A (NZ)
Title: Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
Inventor: BAUM ERICH W
IPC: A01N47/44
Filed: 2016-08-25
Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (I).
Patent NZ-749114-A (NZ)
Title: Chassis assembly and land vehicle
Inventor: HOESSL BERNHARD
IPC: B62D29/00
Filed: 2017-05-19
Abstract: The present invention relates to a chassis assembly for a land vehicle. To achieve high stability, structural integrity, and high load requirements, existing assemblies utilise a relatively high construction height of the chassis assembly, and large wall thickness based on high material input, resulting in a heavy chassis, and a potentially restricted payload. The invention seeks to address these shortcomings of existing assemblies by providing a chassis assembly for a land vehicle, in particular for an off-road truck, having: a chassis frame, an intermediate frame which is connected to the chassis frame and which comprises at least one profiled support which runs in a longitudinal direction of the chassis assembly, and a support installation for supporting a superstructure ( of the land vehicle ), wherein the support installation is mounted so as to be movable on the intermediate frame and comprises a support arm having a support arm through-hole, said support arm running in a transverse direction of the chassis assembly, wherein the at least one profiled support is routed through the support arm through-hole in such a manner that a cross section of the at least one profiled support is at least in portions disposed within the support arm through-hole. On account of the cross section of the at least one profiled support being at least in portions disposed within the support arm through-hole, a particularly low construction height of the chassis assembly and a high stability can be achieved as compared to known assemblies.
Patent NZ-753820-A (NZ)
Title: Method for increasing the secretion levels of interleukin 2 and proteins derived from it
Inventor: ROJAS DORANTES GERTRUDIS
IPC: C07K14/55
Filed: 2017-11-10
Abstract: The present invention relates to the field of biotechnology and, in particular, to a method based on the introduction of a single mutation into genes encoding human IL-2 and the muteins derived therefrom, resulting in increased secretion levels in different hosts without affecting their biological functions. In particular, these mutations are based on a non-conservative change in the amino acid located in position 35 in the primary sequence of human IL-2, preferably the substitutions are K35E, K35D and K35Q. The present invention also relates to the expression systems used to obtain both recombinant human IL-2 and the muteins derived therefrom using the method described in this invention. The above-mentioned method can be used to improve the production efficiency of recombinant human IL-2 and the muteins derived therefrom both on laboratory and industrial scales. The proteins obtained using this method can be used for therapeutic purposes as well as in the in vitro expansion of T cells for adoptive transfer therapies.
Patent NZ-756502-A (NZ)
Title: Degradable sheet material
Inventor: CHAPMAN GRAHAM
IPC: C08K3/105
Filed: 2018-01-08
Abstract: The present invention provides a sheet material formed of a degradeable composition, the composition comprising: 30 to 80 wt% calcium carbonate by weight of the composition; an additive; and the balance a polymer selected from polyethylene, polypropylene and copolymers and blends thereof, wherein the additive comprises, by combined weight of the additive and the polymer: (a) two or more transition metal compounds in a total amount of from 0.15 to 0.6 wt%; (b) a mono-or poly-unsaturated C14-C24 carboxylic acid, or an ester, anhydride or amide thereof, in an amount of from 0.04 to 0.08 wt%; (c) a synthetic rubber in an amount of from 0.04 to 0.2 wt%; and, optionally: (d) dry starch in an amount of from 0 to 20 wt%; and/or (e) calcium oxide in an amount of from 0 to 1 wt%; and/or (f) a phenolic antioxidant stabilizer in an amount of from 0 to 0.2 wt%; wherein the two or more transition metal compounds are selected from iron, manganese, copper, zinc, titanium, cobalt and cerium compounds and wherein the transition metals in the two or more transition metal compounds are different.
Patent PT-101024-A (PT)
Title: Ramp
IPC: G01M7/08
Filed: 1992-10-30
Abstract: The invention consists of a metallic structure, forming a rail similar to a railway line, with the middle part sloping down, where, by means of rollers (bearings), a metallic support with a motor-vehicle seat slides, said seat being provided with the respective safety belt (seat belt). When a person has been seated on the said seat, the latter moves downwards through the action of the force of gravity in an inclined plane and, at the end of travel, stops suddenly against a stop, simulating the impact of a motor vehicle when travelling and proving the benefits of the use of the safety belt. The present invention for a ramp is included in the campaign against road accidents, which aims to save lives and minimize physical injuries, it being possible for it also to be used in playing a new sport, known as "Ramp". The "Automatic unclasping device" created by the inventor, the patent for which was submitted on 27 February 1992, is fitted to the respective safety belt. <IMAGE>
Patent PT-103933-A (PT)
Title: Dispositivo portátil e método para medição e cálculo de parâmetros dinâmicos da locomoção pedestre
Inventor: CORREIA MIGUEL FERNANDO PAIVA
IPC: G01C22/00
Filed: 2008-01-17
Abstract: A INVENÇÃO CONSISTE NUM DISPOSITIVO PORTÁTIL E AUTÓNOMO E RESPECTIVO MÉTODO PARA MEDIÇÃO, REGISTO E CÁLCULO DE PARÂMETROS DINÂMICOS DA LOCOMOÇÃO PEDESTRE DO SEU PORTADOR (1) O MÉTODO DESENVOLVIDO PERMITE DETERMINAR A DISTÂNCIA EFECTIVAMENTE PERCORRIDA, A VELOCIDADE DE DESLOCAÇÃO E AS PRESSÕES EXERCIDAS NA SUPERFÍCIE DE CONTACTO DO MEMBRO INFERIOR (2) COM O SOLO, DURANTE A LOCOMOÇÃO PEDESTRE, EM FUNÇÃO DAS SUAS FASES. ATRAVÉS DE SENSORES ESTRATEGICAMENTE COLOCADOS (3, 4), É REALIZADA A LEITURA DE ACELERAÇÕES, VELOCIDADES ANGULARES E PRESSÕES, AS QUAIS SÃO REGISTADAS NO DISPOSITIVO DE CONTROLO (5) ESTE DISPOSITIVO POSSUI UMA UNIDADE DE PROCESSAMENTO QUE IMPLEMENTA O MÉTODO REFERIDO E UMA UNIDADE DE COMUNICAÇÃO QUE COMUNICA PARA UMA UNIDADE EXTERNA (6) OS PARÂMETROS CALCULADOS. A PRESENTE INVENÇÃO TEM UTILIZAÇÃO EM APLICAÇÕES QUE ENVOLVAM A MONITORIZAÇÃO DE PARÂMETROS DA ACTIVIDADE DE LOCOMOÇÃO E DEAMBULAÇÃO DIÁRIAS DO SEU PORTADOR (1), NAS ÁREAS DA SAÚDE, DESPORTO E EM ACTIVIDADES FÍSICAS E OCUPACIONAIS.
Patent PT-104160-A (PT)
Inventor: NETO CARLOS PASCOAL
IPC: C08G65/28
Filed: 2008-08-20
Abstract: The present invention concerns the process for producing liquid polyols of renewable origin from organic materials such as agro-forestry and agro-food biomass and respective industrial residues, constituting a profitable and bio-friendly alternative to commercial polyols obtained from petrochemical sources. The said process involves two steps in a single reactor: i) the activation of the substrate with an alkaline alcoholic solution (pre-functionalization); ii) the oxypropylation and liquefaction of the activated substrate in heterogeneous conditions. The latter step might also involve the controlled addition of a monomer polyol, also of renewable origin, so as to adjust the properties of the final product, taking the desired applications into account. The present process does not require any specific operations to isolate the end product. The polyols thus obtained can be used in the formulation and preparation of polyurethanes and polyesters being applicable in food, pharmaceutical, furniture, civil engineering, automotive and polymer industries.
Patent PT-104199-A (PT)
Title: Novos complexos de paládio com ligandos bicíclicos de tipo hidropirrolo-oxadiazole, e sua aplicação como catalisadores em reacções de acoplamento de suzuki-miyaura, assistidas por microondas
Inventor: POMBEIRO ARMANDO JOSE LATOURRETTE DE OLIVEIRA
IPC: B01J31/16
Filed: 2008-09-30
Abstract: A INVENÇÃO REFERE-SE A UM NOVO GRUPO DE COMPLEXOS DE PALÁDIO (II) 3 CONTENDO LIGANDOS BICÍCLICOS DO TIPO HIDROPIRROLO-OXADIAZOLE, AO MÉTODO DA SUA PREPARAÇÃO, E AO SEU USO COMO CATALISADORES EFICIENTES E SELECTIVOS EM REACÇÕES DE ACOPLAMENTO CRUZADO DO TIPO SUZUKI-MIYAURA, ASSISTIDAS POR MICROONDAS, PARA A PREPARAÇÃO DE BIARILOS.