baber/WOPTO huggingface dataset:
Patent CR-20170037-A (CR)
Title: Forma de dosificación farmaceutica para administración oral de un inhibidor de la familia bcl-2
Inventor: KNOBLOCH MARTIN
IPC: A61K9/00
Filed: 2010-06-08
Abstract: Una forma de dosificación farmacéutica que comprende un producto de dispersión sólida que comprende N-(4-(4-((2-(4-clorofenil)-5,5-dimetil-1-ciclohex-1-en-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1-((fenilsulfanil)metil)propil)amino)-3-((trifluorometil)sulfonil)bencenosulfonamida o una sal, hidrato o solvato de la misma, al menos un polímero farmacéuticamente aceptable.
Patent CR-20170424-A (CR)
Title: Tratamiento combinado con un agonista de tlr7 y un inhibidor del ensamblaje de la cápsula del vhb
Inventor: DAI LUE
IPC: A61K31/7064
Filed: 2016-03-15
Abstract: La presente invención está dirigida a composiciones y métodos para tratar la infección por el virus de la hepatitis B. En particular, la presente invención está dirigida a una terapia de combinación que comprende la administración de un agonista de TLR7 y un inhibidor del ensamblaje de la cápsida del VHB para su uso en el tratamiento de un paciente con hepatitis B crónica.
Patent EC-SP099651-A (EC)
Title: Compuestos de quinolina apropiados para tratar trastornos que responden a la modulación del receptor de serotonina 5-ht6
Inventor: DRESCHER KARLA
IPC: A61K31/4709
Filed: 2009-09-23
Abstract: La presente invención se relaciona con nuevos compuestos de quinolina. Los compuestos poseen propiedades terapéuticas valiosas y son apropiados, en particular, para tratar enfermedades que responden a la modulación del receptor de serotonina 5-HT6. dondeR es una unidad de la fórmula donde A, R1 a R4 son según se define en las reivindicaciones y en la memoria descriptiva,n  es 0, 1 ó 2;m es 0, 1, 2 ó 3;Ra, Rb se seleccionan independientemente entre el grupo que consiste en halógeno, CN, C1-C4-alquilo, C1-C4-haloalquilo, C1-C4-alcoxi, C1-C4-haloalcoxi, C(O)Raa, C(O)NRccRbb y NRccRbb;X es CH2, C(O), S, S(O) o S(O)2; que está situado en la posición 3 ó 4 del anillo quinolina ;Ar  es un radical Ar1, Ar2-Ar3 o Ar2-O-Ar3, donde Ar1, Ar2 y Ar3 se seleccionan independientemente entre sí, del grupo que consiste en arilo o heteroarilo donde las unidades arilo o heteroarilo pueden no estar sustituidas o pueden contener 1, 2, 3 sustituyentes Rx, donde Rx es como se define en las reivindicaciones y en la memoria descriptiva; y sales de adición ácida toleradas para el uso fisiológico y sus N-óxidos.
Patent EC-SP982609-A (EC)
Title: Sistema y metodo para emision inhalambrica por canales compartidos
Inventor: ZELLNER SAMUEL N
Filed: 1998-07-30
Abstract: Un sistema y método para prestar servicios de emisión inalámbrica por un canal compartido de un sistema celular de comunicaciones. En respuesta a una solicitud por parte de un usuario remoto de servicios de emisión, el sistema y método designan un canal de voz como canal de emisión desactivan el control de calidad para el canal de emisión designado, activan el canal de emisión designado e indican al usuario remoto que hace la solicitud que sintonice el canal de emisión designado. Cada subsiguiente usuario remoto que realice la misma solicitud recibe también la radicación de sintonizar el mismo canal de emisión. De forma similar, en respuesta a una solicitud de un emisor, el sitema y método identifican al usuario remoto para que reciba la emisión, designado, activan el canal de emisión designado e indican a los usuarios remotos identificados que sintonizen el canal de emisión designado.
Patent FI-20020559-A (FI)
Title: Elevator for lifting, comprises guide rails fixed in place by guide fixing bracket whose width in vicinity of car guide rails is equal to width of car guide rail plus thickness of rail clips in bracket
Inventor: MUSTALAHTI JORMA
IPC: B66B/
Filed: 2002-03-22
Abstract: The elevator comprises an elevator car (101) moving along guide rails (1), a counterweight (102) moving along guide rails (2) and an elevator motor (106) driving them. The guide rails are fixed in place by guide fixing bracket (112). The width of the guide fixing bracket in the vicinity of car guide rails (1) is equal to width of the car guide rail (1) plus thickness of the rail clips in the bracket (112).
Patent GB-1047249-A (GB)
IPC: F16K3/312
Abstract: 1,047,249. Valves; pipe closures. ATELIERS HEUZE, MALEVEZ & SIMON REUNIS S.A. March 6, 1964 [May 17, 1963], No. 9522/64. Headings F2P and F2V. A goggle valve comprises annular members 2, 3 joined together and fast with a pinion 16 rotatable about a spindle 5 by a rack 15 interconnecting two single-acting pistons 13, 14. Each piston receives control fluid via a radial bore 20 and a smaller axial bore 21, the arrangement being such that when one piston is actuated a projection 22 on the other piston first obturates its associated bore 20 towards the end of the stroke to prevent shocks. The control fluid is supplied via lines 8, 9 and manually or push-button operated taps. An arm 7 connecting members 2, 3 carries a counterweight 6. The pistons may be arranged in tandem or replaced by a double-acting piston. An oil-bath 17 encloses the rack and pinion.
Patent GB-1050746-A (GB)
IPC: B02C19/06
Abstract: 1,050,746. Jet Pulverizers. MOTALA VERKSTAD A.B. Jan. 20, 1965 [Jan. 21, 1964], No. 2532/65. Heading B2A. [Also in Division E1] Apparatus for disintegrating materials by liquid jets comprises a rotor 61 having radial passages terminating in nozzles which may be directed radially tangentially or, in the embodiment shown, axially, driven by a motor 63. Flow of material to be disintegrated 71 from a container 66 is controlled by a valve 70 and falls into the jet stream at the lower end of a frusto-conical jacket 68. Three nozzles are provided at different distances from the rotor axis and are supplied with water, which may be heated, by a pipe 69 and forms in operation a conical jet field, which is closely surrounded by the jacket 68; material entrained by the jets hits ribs provided on a cylindrical jacket 67. Coarse material continues to the top wall of the main container 64, which has a rounded cavity 72 and falls back into the jet field, fine material passing through the ribs of the jacket 67 for delivery from an exit pipe 65.
Patent GB-1053476-A (GB)
IPC: H01L39/20
Abstract: 1,053,476. Superconductor circuits. NATIONAL CASH REGISTER CO. Sept. 28, 1964 [Oct. 9, 1963], No. 39369/64. Heading H3B. [Also in Division H1] In a superconductive circuit, at least two superconductive paths are connected in parallel and current is supplied so that the sum of the currents flowing in said paths remains substantially constant irrespective of the current distribution. The paths are inductively coupled together by being stacked on each other, with insulating interleaves, so that relatively little change in magnetic field occurs when current is switched from one path to another. The paths may be lead (Pb) strips 16a, 16b on a silicon monoxide insulating layer 14 on a lead superconducting ground plane 12. Controllable tin cryotron gates, e.g. 38, may be incorporated in the lead paths and appropriate control elements, e.g. 40, provided. As shown in Fig. 4, the upper lead strip 16b acts as a bias element for the control element 40. Fig. 5 (not shown) depicts a crossover between upper and lower strips. Many embodiments in which inline or crossed-film cryotrons may be used are described. In Fig. 2 (not shown), a cryotron is incorporated in either the upper or lower path of an inductively coupled pair. In Figs. 7 and 8 (not shown), an inductively coupled pair of paths 16a, 16b is used in conjunction with a bias element 62 to control a cryotron 48 in a third superconducting circuit. In Fig. 9 (not shown), one inductively coupled pair 16a, 16b controls a cryotron 78 in the upper path 116b of a second inductively coupled pair 116a, 116b. In Fig. 10 (not shown), an inductively coupled pair 16a, 16b is used with a bias element 82 to control cryotrons 78, 78<SP>1</SP> respectively in paths 116b, 116a of a second inductively coupled pair. In Fig. 11 (not shown), three inductively coupled paths each contain a cryotron. Fig. 12 (not shown) is a diagram of a logic circuit incorporating inductively coupled paths.
Patent GB-1053954-A (GB)
IPC: D04H3/045
Abstract: 1,053,954. Uniting threads and cords by adhesive. LINDSAY WIRE WEAVING CO. April 2, 1963 [April 2, 1962], No. 13084/63. Heading D1K. An endless belt for draining the water from the pulp in a Fourdrinier paper making machine, comprises two layers of parallel polymeric filaments of non-circular section attached together at an angle to provide a porous structure. As shown, fabric F comprises a layer of heavy carrying filaments 1 and layers of lighter filaments 2, 3 which may be perpendicular. Heavier filaments 2, 3 may be used without carrying filaments or filaments 3 may act as carrying members with closely spaced fine filaments 4. The filaments 2, 3 may be of various cross-sections e.g. square, circular, hexagonal or triangular, Figs. 9-21 (not shown). The heavy filaments may be elliptical or flat with rounded ends and perforated and may have a metallic reinforcement. The filaments may be secured together by solvent cementing, thremofusion or adhesives. Thermofusion may be by direct heating with heated platens or rollers, high frequency dielectric heating, ultrasonics or heated air or liquids. Pressure may be applied at the same time. Suitable materials are cellulose actetate, cellulose acetatebutyrate, polystyrene, polyethylene, polycarbonate, polypropylene, linear polyethylene, polyvinyl chloride, vinyl esters, vinylidene chloride, styrene acrylonitrile, styrene butadiene, polytetrafluorethylene, polychlorotrifluoroethylene, acrylonitrile resin rubber, nylon, methyl methacrylate, ethyl cellulose.
Patent GB-1054415-A (GB)
IPC: B64C9/38
Abstract: 1,054,415. Deflecting propulsion jets. BERTIN & CIE. Feb. 3, 1964 [Feb. 1, 1963], No. 4567/64. Heading B7G. [Also in Division F2] A supersonic nozzle of divergent cross-section comprises a mumber of ducts, the ducts being evenly spaced round the nozzle periphery and being connected at their entry to the divergent wall of the nozzle and arranged at their outlet substantially normal to the axis of the nozzle; each duct having means for controlling the portion of the main gas flow passing through it so that at least one of said ducts can eject a flow substantially transverse to the main gas flow to deflect it. A divergent nozzle 1 (Fig. 1, not shown) of a rocket is formed at its periphery with ducts 2 for tapping a portion of the main jet 3 and diverting it inwards through nozzles 5 to deflect the main jet, control being provided by subsidiary jets through nozzles 6 which, when operative, prevent the entry of gas into ducts 2. Alternatively hinged flaps at the entry to each duct 2 may be operated to control the flow through the ducts. In a further embodiment the inner surface of the nozzle is constructed so as to form a shock wave in the main flow adjacent the entry to each duct, above which is located a suction orifice which may be controlled to suck in the boundary layer to initiate flow through the duct. In other embodiments one or both walls of each duct 2 is or are formed with boundary layer suction apertures. A form of control for the flow through ducts 2 is described and a system of cross-connecting the ducts.
Patent GB-1226830-A (GB)
IPC: G01R33/12
Filed: 1968-09-20
Abstract: 1,226,830. Photo-electric determination of magnetic particle orientation in a coating. AGFA GEVAERT A.G. Sept.20, 1968 [Sept.21, 1967], No.44801/68. Heading G1A. The angle of orientation of magnetizable particles in magnetic recording materials comprising at least one magnetizable coating consisting of a non-magnetic binder in which magnetic particles are dispersed is determined by measuring the intensity of scattered radiation derived from an incident beam of electro-magnetic waves as a function of the angle relative to the desired direction of orientation. One or two beams of light may be directed on to the surface and the intensity of scatter may be measured by a single photo-cell which is relatively rotatable, or a plurality of photo-cells spaced to monitor the intensity at different angles. A preferred arrangement includes two cells with normals to their planes of incidents in planes at 90 degrees to each other. Tape constructions and derived curves are exemplified. Tests on a moving tape during manufacture may be used for control purposes.
Patent GB-1227270-A (GB)
IPC: H02J7/16
Filed: 1969-08-21
Abstract: 1,227,270. A.C. generators. GENERAL MOTORS CORP. 21 Aug., 1969 [11 Sept., 1968], No. 41676/69. Heading H2A. [Also in Divisions G2-G3] A brushless homopolar inductor generator comprises a stator core formed by two aligned stacks of laminations 14, 15, main and reverse field windings 24, 26 and a toothed rotor 30 formed from two stacks of laminations 34, 36 which are aligned with the stator laminations and which carry permanent magnets 52, 54 each aligned with a respective tooth of the other rotor stack. The magnets on each stack have a common radial polarity which is opposite to that of the other stack. Each magnet comprises a permanently magnetized bar secured by a cap 58 and screws 60 to its respective notch, all of which may be provided with magnets if desired (as compatible with the required cooling partially provided by vacant notches). The generator is controlled by a voltage regulator (see Divisions G2-G3) which alternately energizes the windings 24, 26, the arrangement being such that the main winding is aided by the permanent magnets to increase the generator voltage, whilst the permanent magnet field is neutralized by the reverse winding to reduce the generator voltage. Typical air gap fluxes corresponding to these two operating conditions are illustrated and discussed, Figs. 2 and 3 (not shown).
Patent GB-1229364-A (GB)
IPC: F23H9/12
Filed: 1969-11-18
Abstract: 1,229,364. Mechanical grates. C. O. A. EKMAN. 18 Nov., 1969, No. 56473/69. Heading F4B. A mechanical grate for a solid fuel furnace comprises a plurality of longitudinally extending grate bars mounted for reciprocatory longitudinal displacement, said grate bars forming a first group 20a secured to a cross-bar 21 and a second group 20b free to move relative to the cross-bar 21, wherein the said grate bars of each group have a pair of opposite cam surfaces 26a, 27a and 26b, 27b respectively, provided to be engaged by cam flollowers 24a, 24b mounted on a rotatable driving shaft 22 for imparting reciprocable movement to the bars, each of the cam followers including a rotatably mounted wheel or roller 32a, 32b riding on the cam surfaces upon rotation of the driving shaft.
Patent GB-1231417-A (GB)
IPC: A61C1/07
Filed: 1968-11-06
Abstract: 1,231,417. Dental engines. KALTENBACH & VOIGT. 6 Nov., 1968 [8 Nov., 1967], No. 52697/68. Heading A5R. [Also in Division F2] A dental angle handpiece 1 has a head part 3 including a shaft 9 rotating a swash plate 11 acting on the ends of two push rods 12, 13, whose opposite ends engage a drive sleeve 16 so as to convert the rotary motion of the shaft and swash plate to an oscillating rotary motion of the drive sleeve. The sleeve which receives the shank 15 of a dental tool such as a dental canal instrument, is cylindrical and is mounted in the head part of the instrument at right angles to the longitudinal axis thereof so that a recess provides surfaces 16a which are engaged by the tapered ends of the push rods. The head (3) is held on the lower part 1 of the angle handpiece by a sleeve 2. A gearwheel 6 on a drive shaft 5 of the handpiece meshes with a gearwheel 7 on the shaft 9 so that driving power can be transmitted at an angle. The swash plate face 11a may be inclined at an angle of between 50 and 60 to the longitudinal axis of the head part.
Patent GB-1233132-A (GB)
IPC: E21D9/087
Filed: 1969-03-03
Abstract: 1,233,132. Tunnelling machines. EDMUND NUTTALL SONS & CO. (LONDON) Ltd. 5 Feb., 1970 [3 March, 1969], No. 11316/69. Heading E1F. To permit of controlled steering of a tunnelling machine having a digging assembly 2 mounted in a shield 1, which is of smaller diameter than the diameter of cut of the digging assembly, there is secured to the forward part of the underside of the shield a pad 15 and the machine is rocked about this pad in accordance with the relative settings of tunnel wall-engaging presser members mounted on the shield. Preferably four such jack-actuated members are so mounted on the shield that one 16 acts vertically upwards, one 17 vertically downwards and two 18 act in lateral opposition. The vertically acting members 16, 17, are mounted in rearward extensions of the shield and the members 18 are so located on the shield as to be positioned slightly to the rear of the pad 15.
Patent GB-1239436-A (GB)
IPC: C07C67/46
Filed: 1968-12-13
Abstract: 1,239,436. Carboxylic acid esters. BADISCHE ANILIN- & SODA-FABRIK A.G. 13 Dec., 1968 [14 Dec., 1967], No. 69323/68. Heading C2C. Carboxylic acid esters are produced by reacting an alcohol or an enolizable aldehyde or ketone with a ketene in the presence of at least one oxide selected from oxides of metals of Groups I B , II B , IV B , V B , VII B , III A , IV A  or VA of the Periodic System, Mg, Ca, Si, Fe, Co, Ni and Cr as catalyst. The reaction is preferably conducted in an inert solvent using ketene itself. In the examples ethylene glycol mono methyl ether is reacted with ketene to yield glycol monomethyl ether acetate using as catalyst any of the following: CuO, Bi 2 O 3 , ZrO 2 , V 2 O 5 , SnO, CoO 3 , MgO, ZnO, MnO, CaO, In 2 O 3 , SiO 2 , Al 2 O 3 , Cr 2 O 3  or Fe 2 O 3  and SiO 2 .
Patent GB-1250389-A (GB)
IPC: C08G69/20
Filed: 1969-12-05
Abstract: 1,250,389. Polycaproamide. VSESOJUZNY NAUCHNO - ISSLEDOVATELSKY INSTITUT SINTETICHESKOGO VOLOKNA. 5 Dec., 1969, No. 59417/69. Heading C3R. Polycaproamide P is made by anionic polymerization of caprolactam C initiated at 230- 265‹ C. by a catalytic system S containing a diacylated amine D and an alkali salt of phenylacetic acid A. A may be the Na, K, or Li salt. D may be acetylcaprolactam or N-benzoyl caprolactam. There may be 0À1-1À0% moles D. Caprolactam C is dried to 0.025% wt. residual H 2 O, e.g. by use of a molecular sieve, by evacuating the melt, or by bubbling an inert gas through the melt. The C melt is then filtered and system S is introduced. The mixture is stirred under N 2  until S is dissolved, and then heated to polymerization temperature. Polycaproamide P is freed from C, e.g. by steam or vacuum treatment. P may then be formed into fibres. The specific viscosity of P (0.5% solution in tricresol at 20‹ C.) may be 0À57-0À723.
Patent GB-1251145-A (GB)
IPC: A47L11/24
Filed: 1969-04-10
Abstract: 1,251,145. Sweeping machines. G. H. TENNANT CO. 10 April, 1969 [11 April, 1968], No. 18487/69. Heading E1G. [Also in Division A4] In a surface cleaning machine comprising a hopper for receiving material swept by a surface cleaning implement a part of the bottom wall of the hopper, adjacent the entrance therein for swept material, is pivotable about a transverse axis between a position permitting swept material to pass into the hopper and a position in which it substantially closes said entrance. The hopper 18 of a mobile sweeping machine receives material swept by a brush 14 and has at its inlet 23 a section 28 pivotable about an axis 34. During the sweeping operation the section 28 is normally positioned as shown in Fig. 1 with a flexible strip 33 at its rear edge engaging the surface to be cleaned. But when it is desired to displace any material collected adjacent the hopper inlet 23 a linkage 52, 53 is actuated by a hydraulic device 46 to pivot the section 28 about the axis 34 to throw such material forwardly.into the hopper. The hydraulic device 46 may also set the section 28 in a position to close the hopper inlet 23 for retaining the swept material in the hopper whilst it is lifted by hydraulically actuated arms 57 and tilted over a receptacle, into which the hopper contents can then be dumped by releasing the section 28.
Patent GB-1251461-A (GB)
IPC: A61M5/142
Filed: 1970-04-14
Abstract: 1,251,461. Infusion devices. T. H. F. R. ERICSON. 14 April, 1970, No. 17769/70. Heading ASR. An infusion device for intravenous injections, e.g. blood transfusions, comprises a transparent polyethylene drip chamber 5 having one or more inwardly projecting longitudinal V-shaped folds 10 and a non-return valve 2 adapted to open under suction in the drip-chamber 5 to admit blood from the inlet tube 1. The tube 1 is connected to the drip-chamber 5 by a stopper 4 and flange 3. An outlet pipe 8 is connected to a needle via a tube 9 and to the drip-chamber 5 by a second non-return valve 7 opening under excess pressure in the chamber 5 to allow blood to flow from the drip-chamber 5 to the needle. A strainer 6 is attached to the pipe 8 in the drip-chamber. On compressing the drip-chamber 5, blood is expelled through valve 7 and on subsequent release of the chamber 5, blood is drawn into the dripchamber 5 through valve 2. On rapid squeezing and releasing of the drip chamber the blood level therein rises. Under normal conditions the blood drips in through valve 2 and out through valve 7. Ideally the level of blood should be kept above the top of the strainer 6.
Patent GB-1252759-A (GB)
IPC: B64D27/20
Filed: 1968-05-14
Abstract: 1,252,759. Jet propelled aircraft. BRITISH AIRCRAFT CORP. Ltd. 14 May, 1969 [14 May, 1968], No. 22918/68. Heading B7G. [Also in Division F1] In a low wing jet engine aircraft having at least one aft mounted engine 10, 11 mounted on each side of the aircraft's fuselage 1, the air intake duets 14, 15 extend forward of the engine over the aircraft's wing to intakes 16 and 17 which are positioned adjacent to or forward of the wing leading edge. The engines 10, 11 are housed partially within the fuselage contour and partially within blisters protruding from the fuselage, the intake duets being external of the fuselage contour except where the ducts are immediately forward of said engines.
Patent GB-1257755-A (GB)
Inventor: LUCK D G
IPC: E02F3/96
Filed: 1970-06-26
Abstract: 1,257,755. Ripper tooth; shovel combination. ORENSTEIN & KOPPEL (SOUTH AFRICA) (PTY) Ltd. 26 June, 1970 [2 July, 1969], No. 31212/70. Heading E1F. A scoop 1 can be detachably secured to the front of a ripper 2, 5 mountable on a vehicle when an earth or rock-loading operation rather than an earth or rock-ripping operation is required. On the rear face of the scoop is an arcuate channel 11 into which the ripper can, be entered to support the scoop. The flanges of the channel have semi-circular recesses 4 that can engage against a bush 3 of a pivot mounting of the ripper on the vehicle and holes 14 to receive a locating pin which is passed through an aligned hole in the ripper.
Patent GB-1258025-A (GB)
IPC: G06K15/12
Filed: 1970-04-15
Abstract: 1,258,025. Cash registers. NATIONAL GASH REGISTER CO. 15 April, 1970 [8 May, 1969], No. 17885/70. Heading G4T. [Also in Division B6] In a printing machine in which a record or receipt-forming web 40 is imprinted by wheels 14 from a " once only " carbon web 30, the image created thereon is illuminated by a light 50 and projected via lens 52 and mirrors 54, 55 so the matter printed may also be viewed at frosted glass windows 56 and/or 57. The image may either be formed by a hammer 26 or by thermal printing means.
Patent GB-1258154-A (GB)
IPC: C08G59/42
Filed: 1969-05-27
Abstract: 1,258,154. Coated products. RHONE-POULENC S.A. 27 May, 1969 [28 May, 1968; 18 April, 1969], No. 26824/69. Heading B2E. [Also in Divisions C2 and C3] In examples (1) pieces of stainless steel and (11) a copper wire are coated with an N- methyl pyrrolidone solution of a polyamideimide prepared by reacting benzophenone-3, 4, 4'-tricarboxylic acid internal anhydride with bis (4-ethoxycarbonylaminophenyl) methane.