baber/WOPTO huggingface dataset:
Patent AT-E264393-T1 (AT)
Inventor: MONOD MICHEL
IPC: C12N15/09
Filed: 1998-05-06
Granted: 2004-04-15
Abstract: The invention has for object the new recombinant prolyl-dipeptidyl-peptidase enzyme (DPP IV) from Aspergillus oryzae comprising the amino-acid sequence from amino acid 1 to amino acid 755 of SEQ ID NO:2 or functional derivatives thereof, and providing a high level of hydrolysing specificity towards proteins and peptides starting with X-Pro- thus liberating dipeptides of X-Pro type, wherein X is any amino-acid. The invention also provides a DNA molecule encoding the enzyme according to the invention, cells expressing the enzyme according to the invention by recombinant technology, an Aspergillus naturally providing a prolyl-dipeptidyl-peptidase activity which has integrated multiple copies of the Aspergillus native promoter which naturally directs the expression of the gene encoding the prolyl-dipeptidyl-peptidase activity, Aspergillus naturally providing a prolyl-dipeptidyl-peptidase activity which is manipulated genetically so that the dppIV gene is inactivated. The invention provides a method for producing the enzyme according to the invention, comprising cultivating the cells of the invention in a suitable growth medium under conditions that the cells express the enzyme, and optionally isolating the enzyme in the form of a concentrate. The invention provides the use of the enzyme or the cells of the invention to hydrolyse protein containing materials. The invention provides the use of an enzyme and/or a cell providing a prolyl-dipeptidyl-peptidase activity, in combination with at least an enzyme providing a prolidase to hydrolyse protein containing materials. In a last further aspect, the invention provides a food product comprising a protein hydrolysate obtainable by fermentation with at least a microoganism providing a prolyl-dipeptidyl-peptidase activity higher than 50 mU per ml when grown in a minimal medium containing 1 % (w/v) of wheat gluten.
Patent AT-E256281-T1 (AT)
Inventor: KONNO TOMOYASU
IPC: G01K7/00
Filed: 1998-07-13
Granted: 2003-12-15
Abstract: PROBLEM TO BE SOLVED: To stabilize the mounting of a prove cover on a probe, and to improve thermometry precision. SOLUTION: This clinical thermometer is provided with a thermometer main body 2. A supporting stand 7 of the thermometer main body 2 is provided with a large diameter part 71 and a small diameter part 72, and a probe 6 is screwed into the small diameter part 72 so as to be supported and fixed. The probe 6 is covered with a probe cover 11. A ring nut 90 is screwed into the large diameter part 71 of the supporting stand 7. The ring nut 90 is provided with a taper part 92, and an engaged part 93 to be engaged with the probe cover 11 is formed inside the taper part 92. When the probe 6 is covered with the probe cover 11, and the ring nut 90 is mounted, and rotated to a prescribed direction so as to be screwed, a body part 12 of the probe cover 11 is interposed between an inclined part 64 of the probe 6 and the engaged part 93 of the ring nut 90.  Thus, the probe cover 11 can be surely fixed to the probe 6.
Patent AT-E233764-T1 (AT)
Inventor: OHTSUKA YASUO
IPC: A61K31/55
Filed: 1998-09-29
Granted: 2003-03-15
Abstract: Tricyclic triazolobenzazepine derivatives in the form of a prodrug are provided. The compounds according to the present invention are those represented by formula (I) and pharmacologically acceptable salts and solvates thereof. The compounds are useful as antiallergic agents and exhibit excellent bioavailability. <CHEM>  wherein R<1> represents hydrogen, OH, alkyl or phenyl alkyl,   R<2>, R<3>, R<4>, and R<5> represent hydrogen, halogen, optionally protected hydroxyl, formyl, optionally substituted alkyl, alkenyl, alkoxy or the like, and Q represents a group selected from the following groups (i) to (iv), halogen, or alkoxy: <CHEM>
Patent AT-E216989-T1 (AT)
Inventor: DEMIAN IULIA
IPC: C07D217/20
Filed: 1998-09-02
Granted: 2002-05-15
Abstract: This invention describes a process for the isolation of (-)1-(p-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline from a racemic mixture, which involves treating partially resolved mixtures with a formic acid to form a nearly-racemic salt for further resolution.
Patent AT-E226030-T1 (AT)
Inventor: HOPPE CRAIG ALAN
IPC: A23G3/34
Filed: 1998-11-10
Granted: 2002-11-15
Abstract: A food or pharmaceutical composition including a liquid composition comprising the liquid fermentation broth product of a biologically active substance, in a carbohydrate medium other than dairy whey wherein said liquid fermentation broth product has not been subject to any concentrating or drying steps prior to introduction of the broth product into said food or pharmaceutical composition is provided.
Patent AT-E288500-T1 (AT)
Inventor: LEE MARTIN ALAN
IPC: G01N33/50
Filed: 1998-11-27
Granted: 2005-02-15
Abstract: A method for determining a characteristic of a sequence, said method comprising;  (a) adding to a sample suspected of containing said sequence, a probe specific for a target sequence and a DNA duplex binding agent, said probe comprising a reactive molecule able to absorb fluorescence from or donate fluorescent energy to said DNA duplex binding agent,  (b) subjecting said sample to conditions under which the said probe hybridises to the said sequence,  (c) monitoring fluorescence from said sample and determining a particular reaction condition, characteristic of said sequence, at which fluorescence changes as a result of the hybridisation of the probe to the sample or destabilisation of the duplex formed between the probe and the target nucleic acid sequence.    A nucleic acid detection system utilising a similar operating procedure is also described and claimed.
Patent AT-E243325-T1 (AT)
Inventor: DANIELS DAVID JOHN
IPC: G01S13/02
Filed: 1999-08-03
Granted: 2003-07-15
Abstract: A radar includes a signal source for emitting an RF signal and a detector for detecting the RF signal reflected from a target and outputting a signal dependent on the range of the target and the amplitude of the reflected signal and further comprises a means (3) for generating an audio signal whose frequency and amplitude is dependent upon the range of the target and the amplitude of the reflected signal. The operator therefore hears an audio signal which contains information relating to detected targets. Preferably the frequency of the audio signal is dependent upon the range of the target, and the amplitude is dependent upon the amplitude of the reflected signal. <IMAGE>
Patent AT-E399335-T1 (AT)
Inventor: MELISARIS ANASTASIOS
IPC: B29C67/00
Filed: 1999-03-19
Granted: 2008-07-15
Abstract: The present invention relates to stereolithographic compositions containing an actinic radiation-curable and cationically polymerizable organic substance, a cationic initiator, a radical photoinitiator, and at least one cationic reactive modifier containing at least two reactive groups per molecule or at least one polyether polyol or mixtures thereof. The cationic reactive modifier has at least one chain extension segment with a molecular weight of at least about 100 and not more than about 2,000. The polyether polyol has a molecular weight greater than or equal to about 4,000. The use of the cationically reactive modifiers and polyether polyol modifiers substantially increases the flexibility and toughness of the cured articles without compromising photospeed, accuracy and wetting-recoatability of the compositions. The present invention further relates to a method of producing a cured product, particularly three-dimensional shaped articles by treating the composition described above with actinic radiation.
Patent AT-E275605-T1 (AT)
Inventor: ASUMALAHTI MARKKU
IPC: C08F297/08
Filed: 1999-07-01
Granted: 2004-09-15
Abstract: A multimodal polymer composition for pipes is disclosed. The polymer is a multimodal polyethylene with a density of 0.930-0.965 g/cm<3>, an MFR5 of 0.2-1.2 g/10 min, an Mn of 8000-15000, an Mw of 180-330x10<3>, and an Mw/Mn of 20-35, said multimodal polyethylene comprising a low molecular weight (LMW) ethylene homopolymer fraction and a high molecular weight (HMW) ethylene copolymer fraction, said HMW fraction having a lower molecular weight limit of 3500, and a weight ratio of the LMW fraction to the HMW fraction of (35-55):(65:45).
Patent AT-E480784-T1 (AT)
Inventor: HANSEN ROLF
IPC: G01S7/62
Filed: 1999-06-01
Granted: 2010-09-15
Abstract: Method for producing an image of a submerged object (3), e.g. a shipwreck or the sea bottom, comprising the steps of emitting acoustic waves from a first transducer toward a first chosen volume (2), receiving acoustic waves reflected from said volume, the receiver (4) including a two-dimensional array of acoustic sensors being capable of measuring the phase and amplitude of the received waves, from the measured phase and amplitudes calculating the direction of the reflected waves, detecting the maximum amplitude or amplitudes of the waves received from each angular segment and the distance to the reflecting object, the combination of directions of the reflected waves and distances providing a three-dimensional model of said volume, emitting acoustic waves toward a second volume (6) at least partially overlapping said first volume, and repeating steps described above, detecting at least one common feature (3) in the overlapping parts (7) of the measured volume (2, 6) and combining said models by adjusting the relative position(s) and size(s) of said feature(s) for generating a three-dimensional image based on the combination of said models.
Patent AT-E278371-T1 (AT)
Inventor: NEUHANN THOMAS
IPC: A61F2/94
Filed: 1999-08-17
Granted: 2004-10-15
Abstract: A device is disclosed for selectively improving and/or permanently ensuring the permeability for ocular aqueous humour through the trabecular formations into Schlemm's canal. A small tubular element is provided, whose wall material encloses a hollow duct that presents an open configuration on both ends along the longitudinal extension of the hollow duct, so that the size and the shape of the small tubular element correspond approximately to the internal contour of Schlemm's canal, and the wall material as well as the wall thickness are so selected that upon introduction into Schlemm's canal the small tubular element keeps the canal open and dilates adjacent trabecular formations.
Patent AT-E235523-T1 (AT)
Inventor: INGRISCH STEFAN
IPC: C08F283/00
Filed: 1999-10-27
Granted: 2003-04-15
Abstract: Described is a polyurethane/polymer hybrid dispersion with high film hardness, which comprises the reaction components(A) from 3 to 25% by weight of a polyol component consisting of(i) from 2 to 20% by weight of a relatively high molecular mass polyol component,(ii) from 0.5 to 5% by weight of a low molecular mass polyol component,(iii) from 0.5 to 3% by weight of a low molecular mass and anionically modifiable polyol component,(B) from 2 to 20% by weight of a polyisocyanate component,(C) if desired, from 0 to 6% by weight of a solvent component consisting of(i) at least one polyisocyanate-inert organic solvent and/or(ii) a polyisocyanate-inert reactive diluent,(D) from 0.15 to 1.5% by weight of a neutralizing component,(E) from 0.1 to 1% by weight of a chain extender component,(F) from 5 to 40% by weight of a monomer component,(G) from 0.01 to 1.5% by weight of an initiator component,and water as the remainder.The advantages of the polyurethane/polymer hybrid dispersion of the invention, such as high hardness coupled with high flexibility of the crack-free films, good chemical resistance, great stability of the dispersion within a wide pH range, good freeze/thaw stability, and the use of inexpensive raw materials, are achieved in a simplified synthesis route, without subsequence chemical crosslinking, with a simultaneously low organic solvent content (<=4% by weight), and with good filming at temperatures <=+10° C.
Patent AT-E302432-T1 (AT)
Inventor: FLEURY EMMANUEL
IPC: G04G21/04
Filed: 1999-11-26
Granted: 2005-09-15
Abstract: The invention concerns a communication system between a portable unit (1), such as a watch, and a communication terminal (2) such as a personal computer, characterised in that the communication terminal (2) comprises at least means for transmitting (6) a sound signal bearing an information, and the portable unit (1) comprises at least processing means (14) for processing data, and receiving (8) and converting (12) means for picking up said sound signal and converting said sound signal into data to be processed by said processing means (14).
Patent DE-00960798-T1 (DE)
Inventor: MUSCOCEA ANGHEL
IPC: A63B23/12
Filed: 2000-09-06
Abstract: Muscle-building apparatus for press-ups includes a bearing plate having a cushion. A frame includes first and second vertical posts. A first arm has a handle end and a journal end. A first handle is arranged on the handle end of the first arm. A second arm has a handle end and a journal end. A second handle is arranged on the handle end of the second arm. The first arm is movably mounted to the first vertical post between the handle end and the journal end. The second arm is movably mounted to the second vertical post between the handle end and the journal end. A first leg connects the journal end of the first arm to the bearing plate. The first leg is movably mounted to each of the first arm and the bearing plate. A second leg connects the journal end of the second arm to the bearing plate. The second leg is movably mounted to each of the second arm and the bearing plate. Movement of the first and second arms causes movement of the bearing plate.
Patent DE-95907193-T1 (DE)
Inventor: HARTMAN JACOB
IPC: C12P21/00
Filed: 1994-12-29
Abstract: A new method for the prodn. of recombinant human insulin comprises: folding a hybrid polypeptide comprising proinsulin under conditions that permit correct disulphide bond formation; subjecting folded protein to enzymatic cleavage and purifying produced. Also new is polypeptide that contains a leader peptide attached to the N terminus of, is folded and contains correct disulphide bonds.
Patent ES-2226599-T1 (ES)
Inventor: VOIGTMANN JEAN-PIERRE
IPC: B65G47/86
Filed: 2002-11-27
Abstract: Installation for assembling tube components, particularly bodies ( 1 ) with shoulders, comprising the following elements arranged in succession: a linear body conveyor ( 4 ), a transfer system ( 7 ) designed to apply a change in orientation to the bodies ( 1 ) of about 90°, an assembly unit ( 8 ) for fixing the shoulders to the bodies ( 1 ), characterized in that the transfer system ( 7 ) consists of a device ( 9 ) for gripping the bodies and of a device ( 17 ) for changing the orientation of the bodies, the orientation-change device comprising a rotary conveyor ( 17 ), of the conveyor belt type, which is arranged at right angles to the direction of the linear conveyor ( 4 ), the said rotary conveyor ( 17 ) comprising a belt ( 18, 19 ) rotating about a direction that makes an angle of about 45° with the direction of the linear conveyor ( 4 ), the belt ( 18, 19 ) comprising elements ( 15 ) for grasping the bodies, the shape of which is designed so that the bodies ( 1 ) are initially grasped on one of the sides of the rotary conveyor ( 17 ), in a direction parallel to that of the linear conveyor ( 4 ), and that they undergo a change in orientation by 90° when they pass to the other side of the rotary conveyor ( 17 ).
Patent ES-2106699-T1 (ES)
Inventor: STEGNER JOACHIM
IPC: E04B2/84
Filed: 1995-11-08
Abstract: The invention concerns a device for coating building surfaces (1) with curable viscous materials (6). The device comprises a connection piece for delivering viscous material, a nozzle arrangement (2) for applying viscous material, and a smoothing limb (3) for smoothing the surface of a layer once applied. In order to simplify and rationalise the application process and prevent the defects caused by the jet delivery, the application device is designed in such a way that the nozzle arrangement consists of a flat nozzle (2, 7) whose outlet aperture (20) is open towards the building surface (1) and counter to the direction of application (A) in the plane of the applied layer (61, 62, 63, 64), and the smoothing limb (3) of the outlet aperture (20) is immediately adjacent to the flat nozzle (2), extends away from the direction of application (A) and lies tangentially to the applied layer (61, 62, 63, 64). The invention also concerns a method of producing certain objects and elements for buildings and the like using the proposed device.
Patent CY-1107756-T1 (CY)
Inventor: BURTON GERARDO
IPC: A61K31/58
Filed: 2007-10-08
Abstract: The present invention is related to novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues, their use as antiglucocorticoids for the treatment and/or prophylaxis of disease associated to an excess of glucocorticoids. In particular, the invention relates to the use of novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues for treating Cushing's syndrome, iatrogenic hypercortisolism or depression. Also the present invention is related to methods of preparing the novel 21-hydroxy-6,19-oxidoprogesterone (21OH-6OP) analogues.
Patent CY-1108321-T1 (CY)
Title: Καινοφανη παραγωγα δικαρβοξυλικου οξεος
Inventor: CAPET MARC
IPC: C07C229/48
Filed: 2008-09-04
Abstract: Η παρούσα αίτηση διπλώματος ευρεσιτεχνίας αφορά σε νέες ενώσεις με τον τύπο (Ι) που εμφανίζουν αγωνιστική δράση σε υποδοχείς σφιγγοσίνης-1-φωσφορικού, στη διεργασία παρασκευής τους και στη χρήση τους ως ανοσοκατασταλτικοί παράγοντες.
Patent CY-1111289-T1 (CY)
Inventor: RAJ TIWARI
IPC: A61P35/00
Filed: 2010-12-03
Abstract: The invention is directed to 1-nitroacridine derivative(s)/tumor inhibitor(s) compositions as well as methods for using said compositions for inhibiting or preventing tumor growth, particularly, prostate cancer cell growth and metastases.
Patent CY-1112712-T1 (CY)
Inventor: DANIELSSON SPOGARDH STEFAN
IPC: E03D9/02
Filed: 2011-02-22
Abstract: A dosing device for dosing chemicals (9) into outlet water for flushing a toilet having a toilet bowl. The dosing device comprises a place of dosing, at which outlet water and the chemicals are mixed during a flushing of the toilet. The place of dosing is arranged between an inlet to an overflow pipe (5) and an inlet to the toilet bowl.
Patent CY-1113251-T1 (CY)
Title: Παραγωγα σουλφονυλ-κινολινης
Inventor: Galambos János 
IPC: C07D409/12
Filed: 2012-10-25
Abstract: Νέα προσδέματα του τύπου (I), τα οποία προτιμούν τους υπότυπους mGluR1 και mGluR5 υποδοχέα, και/ή τα άλατα και/ή οι ένυδρες ουσίες και/ή τα επιδιαλυτώματα αυτών, οι διαδικασίες και τα ενδιάμεσα για την παρασκευή τους, οι φαρμακευτικές συνθέσεις που περιέχουν αυτές τις ενώσεις και η χρήση τους στην θεραπεία και/ή την πρόληψη μιας κατάστασης, η οποία απαιτεί τροποποίηση των mGluR1 και mGluR5 υποδοχέων. Ο τύπος (I), όπου το Αr1 αναπαριστά μια προαιρετικά υποκατεστημένη φαινυλική ή ετεροαρυλική ομάδα· το Ar2 αναπαριστά μια υποκατεστημένη φαινυλική ή μια προαιρετικά υποκατεστημένη ετεροαρυλική ομάδα· τα R1, R2, R3 και R4 αναπαριστούν ανεξάρτητα έναν υποκατάστατη, ο οποίος επιλέγεται από υδρογόνο, αλογόνο, κυάνιο, αλκύλιο, αλκοξύλιο, υδροξύλιο, τριφθορομεθύλιο, αμίνη, αλκυλαμίνη, διαλκυλαμίνη, αμινομεθύλιο, αλκυλαμινομεθύλιο, διαλκυλαμινομεθύλιο.
Patent CY-1116216-T1 (CY)
Title: Μεθοδος θεραπειας ασθενειας αποθηκευσης γλυκογονου
Inventor: CHEN YUAN-TSONG
IPC: A61P1/16
Filed: 2015-04-23
Abstract: Η παρούσα εφεύρεση αφορά, γενικά, σε Ασθένεια Αποθήκευσης Γλυκογόνου και ιδιαιτέρως, σε μέθοδο θεραπείας Ασθένειας Αποθήκευσης Γλυκογόνου-τύπου-ΙΙΙ και σε ενώσεις και συνθέσεις κατάλληλες για χρήση σε μια τέτοια μέθοδο.
Patent CY-1116480-T1 (CY)
Title: Βακτηριακο στελεχος ξενιστη που περιεχει ενα μεταλλαγμενο spr γονιδιο και μειωμενη δραση tsp
Inventor: ELLIS MARK
IPC: C12N15/70
Filed: 2015-06-18
Abstract: Η παρούσα εφεύρεση παρέχει ένα ανασυνδυασμένο gram-αρνητικό βακτηριακό κύτταρο, το οποίο περιέχει ένα μεταλλαγμένο spr γονίδιο, το οποίο κωδικοποιεί μια spr πρωτεΐνη, το οποίο έχει μια μετάλλαξη σε ένα ή περισσότερα από τα αμινοξέα D133, Η145, Η157, Ν31, R62, 170, Q73, C94, S95, V98, Q99, R100, L108, Υ115, V135, L136, G140, R144 και G147 και όπου το κύτταρο έχει μειωμένη λειτουργία πρωτεΐνης Tsp συγκριτικά με την αντίστοιχη ενός άγριου τύπου κυττάρου.
Patent CY-1119911-T1 (CY)
Title: Βακτηριακα στελεχη απομονωθεντα απο χοιρους
Inventor: KELLY DENISE
IPC: C12R1/25
Filed: 2018-02-14
Abstract: Μία πρώτη πτυχή της εφεύρεσης σχετίζεται με χοίρειο βακτηριακό στέλεχος γαλακτικού οξέος, όπου το εν λόγω βακτηριακό στέλεχος χαρακτηρίζεται από ένα ή περισσότερα από τα ακόλουθα χαρακτηριστικά: (i) την ικανότητα να εκδηλώνει αντιμικροβιακή δραστικότητα έναντι E.coli• (ii) την ικανότητα να εκδηλώνει αντιμικροβιακή δραστικότητα έναντι του S. enteritidis• (iii) την ικανότητα να καταστέλλει φλεγμονή σε κύτταρα IPEC επαγόμενη από 13-οξική 12-0-δεκατετραβοϋλοφορβόλη (ΡΜΑ)• (iv) την ικανότητα να αποκλείει την προσκόλληση ή εισβολή του S. enteritidis σε κύτταρα ΙΡΕC• (v) την ικανότητα να αποκλείει την προσκόλληση ή εισβολή του E.coli σε κύτταρα IPEC• (vi) την απουσία αντιβιοτικής αντίστασης σε ένα ή περισσότερα αντιβιοτικά επιλεγόμενα από τα ακόλουθα: αμπικιλλίνη• κεφοταξίμη• χλωραμφενικόλη• ερυθρομυκίνη• γενταμικίνη• τετρακυκλίνη• βανκομυκίνη• μετρονιζαδόλη• ναλιδιξικό οξύ• και καναμυκίνη• και (vii) την ικανότητα να εμφανίζει θερμική σταθερότητα όταν υποβληθεί σε τρεις κύκλους θέρμανσης, με έκαστο κύκλο να περιλαμβάνει θέρμανση σε θερμοκρασία 70°C για περίοδο 15 λεπτών. Περαιτέρω πτυχές της εφεύρεσης σχετίζονται με συνθέσεις που περιλαμβάνουν τα εν λόγω βακτηριακά στελέχη, και με θεραπευτικές χρήσεις των εν λόγω βακτηριακών στελεχών.
Patent CY-1120792-T1 (CY)
Title: Συνδυασμος μεταξυ 3-[(3-{[4-(4-μορφολινυλμεθυλ)-1η-πυρρολ-2-υλ] μεθυλενο}-2-οξο-2,3-διϋδρο-1η-ινδολ-5-υλ)μεθυλ]-1,3-θειαζολιδινο-2,4-διονης και ενος αναστολεα κινασης-tyr toy egfr
Inventor: BURBRIDGE MICHAËL FRANK
IPC: A61K31/517
Filed: 2018-05-15
Abstract: Συνδυασμός μεταξύ της 3-[(3-{[4-(4-μορφολινυλμεθυλ)-1Η-πυρρολ-2-υλ]μεθυλενο}-2-οξο-2,3-διϋδρο-1Η-ινδολ-5-μεθυλ]-1,3-θειαζολιδινο-2,4-διόνης του τύπου (Ι): ή ενός των Ζ ή Ε ισομερών αυτής ή/και αλάτων προσθήκης με ένα οξύ ή βάση, φαρμακευτικώς αποδεκτά και ενός αναστολέα κινάσης τυροσίνης του υποδοχέα του ανθρώπινου επιδερμικού αυξητικού παράγοντα (EGFR) και χρήση αυτού στην θεραπεία μη μικροκυτταρικού καρκίνου πνεύμονα.
Patent CY-1121177-T1 (CY)
Title: Μεθοδος για την επανατοποθετηση στοιχειων ροης σε μια δομη κωνικης ροης
Inventor: GILRON JACK L
IPC: B01D61/14
Filed: 2019-01-22
Abstract: Μέθοδος για τη λειτουργία μιας κωνικής κινούμενης με πίεση ροής διάταξης που περιέχει ένα μεγάλο αριθμό στοιχείων μεμβρανών, η οποία περιλαμβάνει την τοποθέτηση των αναφερόμενων στοιχείων μεμβρανών σε τουλάχιστον δύο διαδοχικά διατεταγμένα στάδια ροής, έτσι ώστε ο αριθμός των στοιχείων μεμβράνης που λειτουργούν παράλληλα σε ένα δεδομένο στάδιο ροής να είναι μεγαλύτερος από τον αριθμό τους στο επακόλουθο στάδιο ροής, την διέλευση του ρεύματος τροφοδοσίας μέσω ενός σταδίου ροής για τη δημιουργία ενός προϊόντος διαπέρασης και ενός συμπυκνώματος, την κατεύθυνση του αναφερόμενου συμπυκνώματος στο επακόλουθο στάδιο ροής και διέλευση του αναφερόμενου συμπυκνώματος διαμέσου του, με περιοδική αντικατάσταση ενός ή περισσοτέρων από τα στοιχεία μεμβράνης που ανήκουν στο αναφερόμενο επακόλουθο στάδιο ροής με ένα ή περισσότερα στοιχεία μεμβράνης που ανήκουν στο προηγούμενο στάδιο ροής. όπου η περιοδικότητα της αναφερόμενης αντικατάστασης είναι τέτοια, ώστε η επιφάνεια των μεμβρανών που διατίθεται στο επακόλουθο στάδιο ροής να εκτίθεται σε συνθήκες υπερκορεσμού που σχετίζονται με τη διέλευση του αναφερόμενου συμπυκνώματος για μία χρονική περίοδο που είναι βραχύτερη από τον χρόνο που απαιτείται για το αναφερόμενο συμπύκνωμα να καθιζάνει από αυτό ένα ή περισσότερα ελάχιστα διαλυτά άλατα και / ή ανόργανα συστατικά, πάνω στην επιφάνεια των μεμβρανών στο αναφερόμενο επακόλουθο στάδιο ροής κάτω από τις αναφερόμενες συνθήκες υπερκορεσμού, ή να μπορεί να συμβεί απόθεση οργανικών ουσιών στο πρώτο από τα αναφερόμενα δύο ή περισσότερα διαδοχικά διατεταγμένα στάδια ροής. Επίσης παρέχεται μία συσκευή για την διεξαγωγή της προαναφερόμενης μεθόδου.