baber/WOPTO huggingface dataset:
Patent CZ-20002933-A3 (CZ)
Title: 7-alkyl-triazolopyrimidines exhibiting fungicidal activity
Inventor: PFRENGLE WALDEMAR
IPC: A01N43/00
Filed: 1999-02-09
Abstract: A process and intermediates for the preparation of triazolopyrimidine compounds of formula I <CHEM> wherein R<1>, X, L<1>, L<2>, L<3>, L<4> and L<5> are as defined in the description, which comprises reacting alkyl 2-aryl-3-alkyl-3-oxopropionates of formula IV <CHEM> wherein R<1> and L<1>, L<2>, L<3>, L<4> and L<5> are as defined for formula I and R' represents an optionally substituted alkyl group,  a) with 2-amino-Ä1,3,4Ü-triazole, and treating the resulting 5-hydroxytriazolopyrimidines of formula I, wherein X represents a hydroxy group, with a halogenating agent, and b) optionally treating the resulting 5-hydroxytriazolopyrimidines with an alcohol or a thioalkohol in the presence of a base, or with a metal amide, a metal alkyl amide or a metal dialkylamide, or a metal cyanide.A process and intermediates for the preparation of triazolopyrimidine compounds of formula I <CHEM> wherein R<1>, X, L<1>, L<2>, L<3>, L<4> and L<5> are as defined in the description, which comprises reacting alkyl 2-aryl-3-alkyl-3-oxopropionates of formula IV <CHEM> wherein R<1> and L<1>, L<2>, L<3>, L<4> and L<5> are as defined for formula I and R' represents an optionally substituted alkyl group,  a) with 2-amino-Ä1,3,4Ü-triazole, and treating the resulting 5-hydroxytriazolopyrimidines of formula I, wherein X represents a hydroxy group, with a halogenating agent, and b) optionally treating the resulting 5-hydroxytriazolopyrimidines with an alcohol or a thioalkohol in the presence of a base, or with a metal amide, a metal alkyl amide or a metal dialkylamide, or a metal cyanide.
Patent CZ-20003279-A3 (CZ)
Inventor: FOURTILLAN JEAN-BERNARD
IPC: A61P25/00
Filed: 1999-03-17
Abstract: Předkládaný vynález se týká obecného vzorce I (Ta I"), v
nichž X představuje dvojmocný radikál obecného vzorce A B,
Ri, R2, R3 a R4 nezávisle představují H, OH, nižší alkyl, nižší
alkoxy, aryloxy, halogen nebo nitro, nebo nenasycený
alifatický řetězec, nižší alkylkarbonyl, nižší alkylkarbonyloxy,
karboxyl, přičemž tyto skupiny jsou případně substituovány.
R5 představuje H, nižší alkyl, cykloalkyl, aryl, nižší aralkyl,
nižší alkoxy, nižší alkylkarbonyl, halogen(nižší)alkylkarbonyl,
nižší alkyloxykarbonyl, amino, přičemž tyto skupiny jsou
případně substituovány. R6, R7, R9, Rjo, R12, R13, Rm a R15
nezávisle představují H, nižší alkyl, nižší cykloalkyl,
halogen(nižší)alkyl, perhalogen(nižší)alkyl, aryl, aralkyl, nižší
alkoxy, nižší cykloalkoxy, mono, nebo polyhalogenalkoxy,
aryloxy, aralkyloxy, hydroxyalkyl, alkyloxyalkyl, nižší
alkylthio, nižší cykloalkylthio, přičemž tyto skupiny jsou
případně substituovány. R8 představuje nižší alkyl, nižší
cykloalkyl, hydroxyalkyl, hydroxyalkyl, alkyloxyalkyl,
halogen(nižší)alkyl, perhalogen(nižší)alkyl, aryl, přičemž tyto
skupiny jsou případně substituovány. R,i představuje O nebo
S, případně substituované.
Rr (a) nebo ReC=CRj— (b)
β-Karbolinové deriváty s hypnotickými účinky, jejich příprava a použití jako léčebných
přípravků.
Patent CZ-20011585-A3 (CZ)
Title: Casing for moistened wipes
Inventor: TACK JORIS JOZEF GUSTAAF
IPC: B65D85/07
Filed: 1999-11-04
Abstract: The present invention is directed to a container for wetted wipes, comprising a container body (11) with at least one opening, a stationary cover (12) being fitted on, or integrated to said container body, said stationary cover comprising at least one dispensing opening (23) through which the container contents is removed, a movable lid (13) which is movably attached to said stationary cover, or is an integral movable part of the stationary cover, so as to reversibly close said dispensing opening, the container being characterized in that a gas-proof means (16) is located between said stationary cover and said movable lid, for providing a gas-tight barrier between the inside and the outside of the container when the movable lid is in the closed position. Preferably, the tub also comprises a spring element (15) and a releasable lock (14) for automatic opening of the movable lid. <IMAGE>
Patent CZ-20011971-A3 (CZ)
Title: Carboxylic acids and carboxylic acid isosters of N-heterocyclic compounds
Inventor: HAMILTON GREGORY S
IPC: C07D207/12
Filed: 1999-12-03
Abstract: This invention relates to novel N-heterocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, for treating alopecia and promoting hair growth, for treating vision disorders and/or improving vision, and for treating memory impairment and/or enhancing memory performance by administering such compounds.
Patent CZ-20012256-A3 (CZ)
Title: Extraction process of anions of IVB through VIII group metals by making use of alkyl substituted 1,3-diaminopropanes
Inventor: GUTKNECHT WILFRIED
IPC: C07C211/11
Filed: 1999-12-14
Abstract: The invention relates to a method of extracting anions based on metals of groups IV B to VIII of the periodic table from aqueous solutions thereof, wherein compounds of general formulaare used as extractants, in which a maximum of two of the R<1>, R<2>, R<3 >and R<4 >substituents represent hydrogen atoms and the remaining substituents represent identical or different alkyl or aminoakyl groups, which are optionally branched and which contain on average at least 5 C atoms.
Patent CZ-20012784-A3 (CZ)
Title: Device for intravascular cardiac valve surgery
Inventor: SIESS THORSTEN
IPC: A61F2/82
Filed: 2000-02-03
Abstract: For the treatment of an insufficient cardiac valve or a cardiac valve with a stenosis, a device is provided that comprises a micro axial pump (40). The pump portion (14) of the micro axial pump carries a dilating device (18) suitable for pushing open a stenosis in a valve. The dilating device is designed as a high-pressure balloon. During dilation, the micro axial pump (40) operates so that the heart is relieved. With insufficient cardiac valves, a stent (21) is fastened to the dilating device (17), the stent surrounding a flexible cardiac valve prosthesis (20). By dilation, the stent (21) is pressed against the insufficient cardiac valve and the same is passivated. The cardiac valve of the cardiac valve prosthesis is unfolded to assume the function of the natural cardiac valve.
Patent CZ-20012889-A3 (CZ)
Title: Quinazoline derivatives functioning as angiogenesis inhibitors
Inventor: HENNEQUIN LAURENT FRANCOIS AND
IPC: A61P35/00
Filed: 2000-02-08
Abstract: The invention relates to the use of compounds of the formula I:   
wherein ring C is an 8, 9, 10, 12 or 13-membered bicyclic or tricyclic moiety which optionally may contain 1-3 heteroatoms selected independently from O, N and S; Z is -O-, -NH-, -S-, -CH 2 - or a direct bond; n is 0-5; m is 0-3; R 2  represents hydrogen, hydroxy, halogeno, cyano, nitro, trifluoromethyl, C 1-3 alkyl, C 1-3 alkoxy, C 1-3 alkylsulphanyl, -NR 3 R 4  (wherein R 3  and R 4 , which may be the same or different, each represents hydrogen or C 1-3 alkyl), or R 5 X 1 - (wherein X 1  and R 5  are as defined herein; R 1  represents hydrogen, oxo, halogeno, hydroxy, C 1-4 alkoxy, C 1-4 alkyl, C 1-4 alkoxymethyl, C 1-4 alkanoyl, C 1-4 haloalkyl, cyano, amino, C 2-5 alkenyl, C 2-5 alkynyl, C 1-3 alkanoyloxy, nitro, C 1-4 alkanoylamino, C 1-4 alkoxycarbonyl, C 1-4 alkylsulphanyl, C 1-4 alkylsulphinyl, C 1-4 alkylsulphonyl, carbamoyl,  N- C 1-4 alkylcarbamoyl,  N , N -di(C 1-4 alkyl)carbamoyl, aminosulphonyl,  N -C 1-4 alkylaminosulphonyl,  N , N -di(C 1-4 alkyl)ammosulphonyl,  N -(C 1-4 alkylsulphonyl)amino,  N- (C 1-4 alkylsulphonyl)- N -(C 1-4 alkyl)amino,  N , N -di(C 1-4 alkylsulphonyl)amino, a C 3-7 alkylene chain joined to two ring C carbon atoms, C 1-4 alkanoylaminoC 1-4 alkyl, carboxy or a group R 56 X 10  (wherein X 10  and R 56  are as defined herein); and salts thereof, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals, processes for the preparation of such compounds, pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof as active ingredient and compounds of formula I. The compounds of formula I and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.
Patent CZ-20013660-A3 (CZ)
Title: Substituted 3-cyano-(1,7),(1,5) and (1,8)-naphthyridine inhibitors of tyrosine kinases
Inventor: WISSNER ALLAN
IPC: A61K31/4375
Filed: 2000-04-18
Abstract: This invention provides compounds of formula (I) having structure (a) wherein A'' is a diavalent moiety selected from the group (a, b, c) which are useful as inhibitors of protein tyrosine kinase.
Patent CZ-20013778-A3 (CZ)
Title: Pharmaceutical preparations containing inhibitors of human kinase h-sgk regulated by cellular volume and use thereof
Inventor: WALDEGGER SIEGFRIED
IPC: A61K38/00
Filed: 2000-04-19
Abstract: The invention relates to medicaments which contain inhibitors or activators of cell-volume regulated human kinase h-sgk. Medicaments of this type are suitable for treating conditions, in which an increased or reduced expression of h-sgk is identified.
Patent CZ-20021731-A3 (CZ)
Title: Continuous process for preparing polyether polyols
Inventor: HINZ WERNER
IPC: C08G65/26
Filed: 2000-08-03
Abstract: A continuous alkoxylation process for the production of polyether polyols is disclosed. The process comprises the use of a plurality of reaction modules each having an outer tube and an inner tube with annular chamber between them. A spiral reaction tube is spaced from the inner tube and winds around the inner tube within the annular chamber. The spiral reaction tube includes an inlet and an outlet, each of which extend through said outer tube. A heat exchange medium flows through the annular chamber and controls the reaction temperature in the spiral reaction tube. The process comprises continuously forming an initial reaction mixture of at least one alkaline oxide and an initiator having at least one reactive hydrogen which is reactive to the alkaline oxide. Continuously flowing the initial reaction mixture through a first spiral reaction tube having an internal diameter and a spiral diameter that promote a pseudo-turbulent flow of the initial reaction mixture through the first spiral reaction tube to form a reaction product. Then flowing the reaction product into a second spiral reaction tube and adding a catalyst and an alkaline oxide to the reaction product, the second spiral reaction tube having an internal diameter and a spiral diameter that promote a pseudo-turbulent flow of the reaction product, the catalyst and the alkaline oxide in the second spiral reaction tube.
Patent CZ-20023402-A3 (CZ)
Title: Fishing throw off buoy
Inventor: SVOBODA JIRI
IPC: A01K97/00
Filed: 2002-10-14
Abstract: The fishing throw-off buoy composed from double float and from anchoring load of the fish-line, where the parts of float are connected with a distancing tube with a going­through fish-line. The partly the front part (11) of float (1) with rubber lock (2) for the fish­bait is located on the front part of distancing tube (3) and the rear part (12) is located sliding on the distancing tube (3). The front part (31) of which has a greater outer diameter as the rear part (32), which is provided with an end stop (33) of rear part (12) of float (1). Partly the anchoring load (5) of fish-line (4) is composed from cylinder (51) eccentrically and sliding located on the front part (31) of distancing tube (3) and in the wall of which is in the reduced diameter place and parallel to axis a cut opening (52) is provided the width of which is greater as the diameter of rear part (32) of distancing tube (3) and less as the outer diameter of front part (31) of distancing tube (3). The cylinder (51) is with help of short thimble (53) fastened to the cap ring (54) sliding on the distancing tube (3) between the rear part (12) of float (1) and between the end stop (33), the inner diameter of which is greater as the outer diameter of end stop (33).
Patent CZ-20031262-A3 (CZ)
Title: Liposomal formulation of mitoxantrone
Inventor: AHMAD IMRAN
IPC: A61P35/00
Filed: 2001-10-16
Abstract: This invention pertains to liposomal formulations of mitoxantroneand methods for their manufacture and use. The compositions of the present invention include liposomal formulations of mitoxantrone in which the liposome contains any of a variety of neutral or charged liposome-forming materials in addition to a compound that is thought to bind mitoxantrone, such as cardiolipin. The liposomal compositions can be used advantageously in conjunction with secondary therapeutic agents other than mitoxantrone, including antineoplastic, antifungal, antibiotic among other active agents. Methods are provided in which a therapeutically effective amount of the formulation is administered to a mammal, such as a human.
Patent CZ-20032737-A3 (CZ)
Title: Method and device for the two-step production of acrylic acid
Inventor: BUSCHULTE THOMAS
IPC: G01N21/3504
Filed: 2002-04-08
Abstract: The invention relates to a method for producing  alpha , beta -ethylenically unsaturated aldehydes and/or carboxylic acids by two-step catalytic gas phase oxidation which is characterized in that in the first step (1) a gas mixture containing at least alkane or alkene having three to six carbon atoms and oxygen is subjected to a catalytic oxidation reaction. Oxygen is supplied to the gases produced in the first step (1) and the resulting mixture is added to the second step (2) in which it is subjected to another catalytic oxidation reaction. The inventive method is further characterized in that a signal is obtained that is correlated with the oxygen content of the reaction gases before and/or after addition of oxygen between the first and second step (1, 2) and in that the oxygen supply is controlled on the basis of said signal. The invention further relates to a device for controlling a method for producing  alpha , beta -ethylenically unsaturated aldehydes and/or carboxylic acids and to a device for producing said substances using the inventive control device.
Patent CZ-20033342-A3 (CZ)
Title: Vehicle temperature control system
Inventor: HUMBURG MICHAEL
IPC: F25B27/00
Filed: 2003-12-08
Abstract: A vehicle temperature control system has an air-conditioning apparatus (12) with an arrangement of compressor devices (14, 40) to apply pressure to a working medium of the air-conditioning apparatus (12). The arrangement of compressors is driven by a Stirling motor (42). A fuel-operated heater (54) is assigned to said Stirling motor (42) for providing a heating medium for heating a hot area (48) of said Stirling motor (42). A cooling medium circuit (50) is provided to said Stirling motor (42) for feeding a cooling medium to a cold area (46) of said Stirling motor (42). The temperature control system of the present invention further includes a heating heat exchanger (38) integrated into a coolant medium circuit (32) of a vehicle drive motor (18) of the vehicle, to which heating medium generated in the heating device (54) for heating air delivered to the vehicle interior, can be supplied.
Patent DD-146737-A3 (DD)
Title: Implantierbarer druckwandler fuer physiologische untersuchungen
Inventor: ZESCHKE GERHARD
IPC: A61B5/02
Filed: 1978-02-10
Abstract: Der implantierbare Druckwandler fuer physiologische Untersuchungen ist als ein mit Fluessigkeit gefuellter und beidseitig verschlossener Folienschlauch ausgebildet und weist drei funktionelle Anschnitte auf. Der in der Blutbahn befindliche Abschnitt uebertraegt im Verlaufe von mehreren Wochen oder Monaten kontinuierlich Maszwerte ueber Blutdruckaenderungen im physiologischen Druckbereich zwischen 0 und 300mm Hg an das auszerhalb des Blutgefaesze befindliche Wandelement, das im Innern des Koerpers implantiert ist. Der Druckwandler ist besonders fuer Tierexperimente in der Forschung und in der pharmazeutischen Industrie einsetzbar.
Patent DD-231703-A3 (DD)
Title: Stoesselverstellung einer presse
Inventor: WENDT GISELA
IPC: B30B15/00
Filed: 1984-08-22
Abstract: Die Erfindung bezieht sich auf eine Stoesselverstellung einer Presse zum Veraendern des Abstandes zwischen Tisch und Stoessel. Ziel und Aufgabe der Erfindung ist es, eine Stoesselverstellung so zu verbessern, dass die Gewindeflanken zwischen Gewindespindel und Verstellmutter zur Beseitigung des Gewindespieles waehrend des Arbeitshubes der Presse formschluessig verbindbar und zum Verstellen loesbar sind. Dies wird erfindungsgemaess dadurch geloest, dass ein Axialkurvenscheibenpaar 8 zwischen Lagerdeckel 7 und Stellmutter 4 mit analog spiegelbildlich zueinander aufweisenden Kurvenbahnabschnitten 8.4 angeordnet ist, deren untere Axialkurvenscheibe 8.2 durch eine Zylinder-Kolben-Einheit 9; 9.1 mit Waelzverbindung 9.4; 8.5 drehbar, sich auf der feststehenden oberen Axialkurvenscheibe 8.1 abstuetzend, gegen die Stellmutter 4 anpressbar gelagert ist, wobei die Kolbenstange 9.1 durch eine bewegliche Klemmbacke 11 arritierbar ist. Fig. 1
Patent DD-246002-A3 (DD)
Title: Schaltungsanordnung fuer den endlagenhalt eines hydraulischen oszillierantriebes einer werkzeugmaschine, vorzugsweise hobelmaschine
Inventor: SOMMERSCHUH STEFAN
IPC: B23Q5/26
Filed: 1984-11-12
Abstract: Die Erfindung betrifft eine Schaltungsanordnung fuer Endlagenhalt hydraulischer Oszillierantriebe. Ziel der Erfindung ist die Vermeidung von Werkzeugbruch und erhoehten Werkstueckwechselzeiten durch Fehlschaltungen und damit die Verminderung von Material-, Werkzeug- und Fertigungskosten. Aufgabengemaess wird die Unterbrechung der Oszillierbewegung, von manuellen sowie geschwindigkeits- und masseabhaengigen Einfluessen unabhaengig, exakt in vorbestimmten Endlagen realisiert. Erfindungsgemaess sind die Steuerzylinderraeume des Steuerschiebers mit jeweils zugeordneten Steuerkanaelen ueber Steuerdruckanschluesse und einem externen Wegeventil mit der Druckmittelquelle verbindbar, wobei Stelleinheiten des Wegeventiles in Stellungsabhaengigkeit des Umsteuerhebels von Endschaltern ueber einen elektrischen Schaltkreis ansteuerbar sind. Fig. 1
Patent DD-249150-A3 (DD)
Title: Verfahren zur herstellung einer polymermatrix fuer schwach basische anionenaustauscherharze
Inventor: PIENTKA VOLKER
IPC: B01J41/14
Filed: 1985-04-02
Abstract: Verfahren zur Herstellung einer Polymermatrix fuer schwach basische Anionenaustauscherharze. Ziel der Erfindung ist die Herstellung einer Polymermatrix fuer schwach basische Anionenaustauscherharze, die bei einem Belastungsanstieg einen geringeren Abfall der nutzbaren Volumenkapazitaet zeigen als die dem bisherigen Stand der Technik entsprechenden Harze. Die Erfindung beruht auf der Herstellung einer kinetisch verbesserten Polymermatrix, die dann entsteht, wenn die Polymerisationstemperatur in einem definierten Umsatzbereich zwischenzeitlich gesenkt wird.
Patent DD-249605-A3 (DD)
Title: Greifer fuer kleinteile
Inventor: HAEBLER HANS-PETER
IPC: B65G47/90
Filed: 1985-05-03
Abstract: Die Erfindung betrifft ein einfaches selbstklemmendes Element zum Greifen und Ablegen von vorzugsweise flachen Kleinteilen zum Zwecke des Montierens, Stapelns, Entstapelns und dergleichen. Ziel der Erfindung ist die Vereinfachung bzw. Verbesserung von Fertigungsablaeufen wie Montieren, Umsetzen, Stapeln, Entstapeln usw. Die Aufgabe der Erfindung ist das lageorientierte Greifen und Ablegen eines oder einer Gruppe von Teilen ohne zusaetzlichen Antrieb unter Verwendung eines Minimums an bewegten Teilen. Der Greifer ist fuer manuelle wie fuer maschinelle Anwendung geeignet.
Patent EP-1031272-A3 (EP)
Inventor: BISCHOFF LUTZ
IPC: A01F12/40
Filed: 2000-01-25
Abstract: Die Erfindung bezieht sich auf eine Verteilvorrichtung einer
Zerkleinerungsvorrichtung, mit einem Gehäuse (76), das einen
ersten Bereich (54) und zweiten Bereich (68) aufweist, einem
Zerkleinerungs- und Förderelement und mehreren Leitblechen
(64) zur transversalen Streuung des Fördergutes, wobei der
zweite Bereich (68) des Gehäuses (76) relativ zum ersten
Bereich (54) des Gehäuses (76) um eine erste Achse (56)
schwenkbar ist, und Fördergut durch das Förderelement am
ersten (54) und zweiten Bereich (68) vorbei in Richtung auf
die Leitbleche (64) zu gefördert wird. Derartige Vorrichtungen
finden insbesondere an Erntemaschinen (10), wie Mähdreschern,
Verwendung, um gehäckseltes Erntegut auf einem Feld zu
verteilen. Um eine optimale seitliche Verteilung des Förderguts
zu erreichen, und die Verteilvorrichtung ggf. in eine günstige
Position für den Straßentransport bringen zu können, wird
vorgeschlagen, daß die Leitbleche (64) relativ zum ersten
Bereich (54) des Gehäuses (76), separat vom zweiten Bereich
(68) des Gehäuses (76), schwenkbar angeordnet sind.
Patent EP-1029665-A3 (EP)
Inventor: CANTI MAX
IPC: B32B37/16
Filed: 2000-02-16
Abstract: The invention refers to a machine for carrying out sandwich panels including:   capstans and drive rolls (3, 4, 6), fit for feeding and converging side panels (1, 2) onto a moving honeycomb frame (5); sensor means (7, 8, 9) fit for aligning the panel (1, 2) and the frame (5) to be joined;   spreading heads (15, 16) of an adhesive; a continuous roller pressing station displaced near the adhesive spreading heads (15, 16).   <IMAGE>
Patent EP-1054241-A3 (EP)
Inventor: OTTO STEFAN
IPC: G01F23/72
Filed: 2000-02-26
Abstract: The level probe has a guide tube containing a series of magnetic sensors and guiding a float (7) that generates a magnetic f for operating the sensors. An end piece (3) of the guide tube (4) contains a magnetic sensor and protrudes into a tube stump attached to the top or bottom of a tank such that it is held by the stump in the radial direction. The external profile of the t stump and that of the guide tube are selected so that the float can move far enough over the tube stump to operate the sensor.
Patent EP-1033811-A3 (EP)
Title: Monolithic fixed active equalizer
Inventor: TANG BENJAMIN
IPC: H04B3/04
Filed: 2000-03-02
Abstract: A cable equalizer (20) formed as an active filter that is amenable to being
fabricated from heterojunction bipolar transistor (HBT) technology and thus, can be
rather easily fabricated as a monolithic integrated circuit, consuming only nominal
amounts of power and chip area. The active filter includes a pair of differentially
connected transistors, such as HBT transistors (Q1A, Q1B), configured with a
degeneration resistor (2R) and a shunt capacitance (C D /2). The active filter (20) is
able to provide a high frequency boost with linear phase performance.
Patent EP-1038894-A3 (EP)
Inventor: CHEN NING
IPC: C07C233/05
Filed: 2000-03-23
Abstract: A composition having the formula:
 
wherein R is a linear alkyl, branched alkyl, cycloalkyl, polycyclic alkyl, alkylaminoalkyl, or
alkyloxyalkyl group having 1 to 20 carbon atoms and at least one primary, secondary, or
tertiary amino functional group. The composition is effective as a catalyst in the
production of polyurethanes.
Patent EP-1045079-A3 (EP)
Inventor: YAMAMOTO NAOTAKA
IPC: E04B1/80
Filed: 2000-04-11
Abstract: A heat insulating wall (50) comprises a laminated body including a first panel (51A), a first plate-shaped insulating material (53) made of plastic foam and having a predetermined thickness, a vacuum insulation member (60) mounted on the material (53), a second plate-shaped insulating material (53) made of plastic foam, and a second panel (51B). The area between the first and second panels (51A,51B) surrounded by the first plate-shaped insulating material (53), the vacuum insulation member (60), and the second plate-shaped insulating material (53), is filled with expanding plastic foam (55). The thickness of the first and second plate-shaped insulating materials (53,53) are set to a predetermined thickness (S). <IMAGE>