baber/WOPTO huggingface dataset:
Patent EA-009559-B1 (EA)
Title: Aβ IMMUNOGENIC PEPTIDE CARRIER CONJUGATES AND METHODS OF PRODUCING SAME
Inventor: ARUMUGHAM RASAPPA G
IPC: C07K/
Filed: 2004-12-17
Abstract: The present invention is directed to methods of producing conjugates of Abeta peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein any unconjugated reactive functional groups on amino acid residues are inactivated via “capping”, thus retaining the immunological functionality of the carrier molecule, but reducing the propensity for undesirable reactions that could render the conjugate less safe or effective. Furthermore, the invention also relates to such immunogenic products and immunogenic compositions containing such immunogenic products made by such methods.
Patent EA-010262-B1 (EA)
Title: Method for producing oil-honey biologically active additive to foodstuff
Inventor: KHARCHENKO STANISLAV ALEXANDROVICH
IPC: A23L17/00
Filed: 2006-09-25
Abstract: The invention relates to food and pharmaceutical industries and, in particular to a method for producing biologically-active additive to foodstuff based on oil of marine mammals and bee honey. A problem put technically is to improve technology of commercial production of oil-honey additive aimed at reducing power consumption and simplification of the production process, wherein preserving to maximum biologically-active components and increasing shelf life. A method for producing the biologically-active additive is proposed comprising honey, oil, gel-forming agent and water, according to the invention aqueous solution of the gel-forming agent is mixed with oil and honey by adding honey to the aqueous solution of the gel-forming agent at up to 60°C, pouring the produced mixture to flasks adding some oil above the mixture and subsequent closing thereof.
Patent EA-009348-B1 (EA)
Title: Method for collecting and removing domestic wastes and motor vehicle therefor
Inventor: YANKOVSKY IGOR VLADIMIROVICH
IPC: B30B13/00
Filed: 2006-08-23
Abstract: The invention relates to municipal facilities and intended for collection and removal of domestic wastes.A motor vehicle for collecting and removal of domestic wastes comprises a body with a loading window and a rear board mounted on a chassis of the motor vehicle; a device for compacting domestic wastes arranged in the body and embodied as a pushing out plate on a carriage with a moving mechanism, a control block of the moving mechanism drive motor, pick-ups of the pushing out plate position in the initial and back extreme position, FORWARD, REAR and STOP position knobs, a signaling device for implementing FORWARD and REAR commands, an operation mode switch : LOAD and DISCHARGE; a compression pick-up of domestic wastes having a sensitive element , a measuring scale, a pointer of a real compression load; selector of MAXIMUM and MINIMUM compression effort, an automatic control device of maximum-permitted volumetric load with a load limit pick-up and a maximum load sound signaling device.A novel feature is characterized in that the pushing out plate is provided with a device for punching different plastic articles etc., being a part of domestic wastes.The inventive claim of the method for collecting and removing domestic wastes is further characterized in that after reaching the predetermined compression load a t1 time delay is created for complete punching said articles, air removal therefrom and final compaction thereof due to the increase of the compaction coefficient, wherein sharp pins of the pushing out plate are automatically cleaned by an additional spring-loaded plate when the pushing out plate moves backward.
Patent EA-008658-B1 (EA)
Title: Rail fastening
Inventor: AKSENOV JURYI NIKOLAEVICH
IPC: E01B9/38
Filed: 2005-09-23
Abstract: The inventive rail fastening relates to a top railtrack structure and is used for fixing rails to a rail seat such as a sleeper, plate etc. Said rail fastening comprises an anchor bonded into a concrete sleeper and a resilient tie pad disposed between the anchor heads on the rail seat. Two spring terminals interacting with the anchor head cantilevers by the tongues thereof through a voltage controller rest on a terminal bearing by the round parts and press a rail to a sleeper by the rectilinear sections thereof thorough an over-rail insulating plate, wherein said plate is embodied in the form of a corner which is provided with a claw in the middle section thereof and whose vertical wing is disposed between the side face of the rail flange and the anchor head cantilevers. The internal side of the anchor head base is embodied such that it is rectilinear along the matching section with the over-rail insulating plate in the form of the extension of the vertical surfaces of the anchor head cantilevers. The external side of the anchor head base is provided with a pattern draft, the side faces thereof are rectilinear and the angle interfaces are radially embodied. Said invention makes it possible to increase the performance reliability of the rail fastening, to use hard and wear-resistant over-rail insulating plates and to prevent the rapid breakdown thereof, in particular on curved tracks.
Patent EA-012822-B1 (EA)
Title: Compositions for disinfecting inanimate surfaces
Inventor: POMYTKIN IGOR ANATOLIEVICH
IPC: A01P1/00
Filed: 2005-03-11
Abstract: This invention relates to compositions for disinfecting an inanimate surface comprising an effective disinfecting amount of a disinfectant and water, which water comprises from about 99.760 to about 99.999% of light isotopologueHand up to 100% of residual isotopologuesHO,HO,HHO,HHO,HHO,HO,HO andHO. The disinfectant is selected from the group consisting of aldehydes, alcohols, phenol compounds, quaternary ammonium compounds, chlorhexidine, halogen compounds, peroxides and hydroperoxides. Furthermore, the infection relates to a method of disinfecting an inanimate surface, which comprises a step of contacting said surface with the composition presented by the invention.
Patent EA-012628-B1 (EA)
Title: 3,3a,8,12b-TETRAHYDRO-2H-DIBENZO[3,4:6,7]CYCLOHEPTA[1,2-B]FURAN
Inventor: FERNANDEZ-GADEA FRANCISCO JAVIER
IPC: C07D405/06
Filed: 2006-05-17
Abstract: This invention concerns novel tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain with binding affinities towards serotonin receptors, in particular 5-HTand 5-HTreceptors, and towards dopamine receptors, in particular dopamine Dreceptors, pharmaceutical compositions comprising the compounds according to the invention, the use thereof as a medicine, in particular for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic, cardiovascular and gastrokinetic disorders and processes for their production. The compounds according to the invention can be represented by general Formula (I) and comprises also a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof, and a quaternary ammonium salt thereof, wherein all substituents are defined as in Claim 1.
Patent EA-014754-B1 (EA)
Title: Novel camptothecin analogues compounds, a method for the preparation thereof and pharmaceutical compositions containing said compounds
Inventor: LAVIELLE GILBERT
IPC: A61K31/4745
Filed: 2006-08-04
Abstract: Compounds of formula (I):wherein R, R, R, R, R, R, R, R, R, Alk, Alk', X, X' and G are such as defined in the description. Medicaments.
Patent EA-019524-B1 (EA)
Title: COMPOUNDS AND COMPOSITIONS AS c-kit AND PDGFR KINASE INHIBITORS
Inventor: LI XIAOLIN
IPC: A61K31/506
Filed: 2008-05-02
Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of c-kit, PDGFRα and PDGFRβ kinases.
Patent EA-015848-B1 (EA)
Title: 6,9-disubstituted purine derivatives and their use for treating skin
Inventor: SZUCOVA LUCIE
IPC: A61K31/375
Filed: 2007-07-10
Abstract: The present invention provides methods and compositions for countering the adverse effects of aging on mammalian cells in vitro and in vivo, especially human skin cells and human skin, and treatment of hyperproliferative and related skin diseases in mammals by administering compositions containing 6,9-disubstituted purine derivatives.
Patent EA-019709-B1 (EA)
Title: Spirocyclic heterocycles and use thereof as medicaments
Inventor: HIMMELSBACH FRANK
IPC: A61K31/517
Filed: 2009-02-05
Abstract: The invention relates to spirocyclic heterocycles of general formula (I)to their tautomers, stereoisomers, mixtures and salts, in particular their physiologically compatible salts, comprising inorganic or organic acids with valuable pharmacological characteristics, in particular an inhibitory action on signal transduction that is mediated by tyrosine kinases. The invention also relates to the use of said heterocycles for treating diseases, in particular tumorous diseases, and benign prostatic hyperplasia (BPH) and for treating diseases of the lungs and respiratory tract and to the production of said heterocycles.
Patent EA-018123-B1 (EA)
Title: Method for atomic absorption analysis
Inventor: BUZUK ALEXANDER ALEXANDROVICH
IPC: G01J3/42
Filed: 2010-06-29
Abstract: The invention refers to atomic absorption spectrophotometry and is suitable for use during atomic absorption analysis and spectral instrument engineering. The object of the invention is to increase the accuracy of measurement during nonlinear variation of nonselective absorption. The object in the method for atomic absorption analysis is realized by that in view of nonselective absorption correction including alternating excitation of radiation of a hollow cathode lamp and continuous spectrum lamp by current pulses, passing the lamps radiation through atomic vapor, determining correction degree of nonselective absorption and finding optical density of the atomic vapor, the duration of current pulses is set not less than the duration of stabilization of lamps radiation, and the correction degree is determined for the field moments of the hollow cathode lamp.
Patent EA-015414-B1 (EA)
Title: Mixture for preparing dietary dough and method for making bakery products based thereon
Inventor: SCHNEIDER TATIANA ILJINICHNA
IPC: A21D2/00
Filed: 2010-12-22
Abstract: The invention relates to food industry, in particular to preparing dough mixtures using gluten-free raw compound and to a production of dietary products based thereon. A mixture is proposed for preparing dietary dough comprising a gluten-free raw compound, pectin, citric acid, cooking soda and a thickener with definite component ratio and a method is also proposed for making bakery products based on said mixture comprising a mixture preparation from gluten-free material and edible additives, introducing thereof into a flour mixture, dough and mass shaping with subsequent proof and baking, wherein salt, sugar, yeast, vegetable oil and water are added during dough, the proof is performed in an oven at 20-40°C during 45-60 min after which bake product at 200-220°C. The use of the invention provides to improve consumer properties of dietary flour product.
Patent EA-024093-B1 (EA)
Title: Catalyst useful in fisher-tropsch synthesis
Inventor: KARIM KHALID
IPC: C10G2/00
Filed: 2011-12-15
Abstract: The present invention relates to a catalyst composition comprising cobalt manganese oxide which is modified with lanthanum and/or phosphorus and optionally one or more basic elements selected from the group consisting of alkali metal, alkaline earth metal and transition metal. Furthermore, a method for preparing said catalyst composition and a process for producing aliphatic and aromatic hydrocarbons by Fischer-Tropsch synthesis using said catalyst composition is provided.
Patent EA-036170-B1 (EA)
Title: Bucket for cable shovel
Inventor: BRISCOE TERRY L
IPC: E02F3/60
Filed: 2013-08-29
Abstract: A bucket for use with a cable shovel includes a shell and a door collectively defining a cavity for gathering material to be excavated. The door is pivotally secured about a pivot axis on the shell so that the door can pivot between a closed position for gathering the material and an open position for dumping the material. The pivot axis is positioned forward of an exterior surface of a back wall of the shell to create a shallower and less forceful door swing during dumping. The door has a front portion that is bent towards a digging edge on the shell so that the door has greater strength, improves bucket loading, and moves a portion of the shell away from the highest wear area.
Patent EA-031911-B1 (EA)
Inventor: DU PENG
IPC: G09G3/20
Filed: 2013-12-30
Abstract: В описании представлено дисплейное устройство и способ восстановления его испытательной линии, при этом способ включает этапы разрыва соединения между первым входным концом первого тонкопленочного транзистора (TFT), первым выходным концом и испытательной линией для входного сигнала и соединения первой вспомогательной линии и испытательной линии для выходного сигнала с помощью способа лазерной сварки. Отношение ширины к длине в дисплейном устройстве согласно настоящему изобретению будет неизменным, и в испытании при включении света не произойдет неисправность дисплея.
Patent EA-032203-B1 (EA)
Title: Tubulysin derivatives
Inventor: GINGIPALLI LAKSHMAIAH
IPC: C07D277/30
Filed: 2015-04-10
Abstract: Novel tubulysin derivatives which may be useful as cytotoxic agents to provide therapeutic benefits in the treatment of various types of cancers, alone or as drug conjugates with antibodies are provided. The tubulysin derivatives consist of a tetrapeptide scaffold comprising methyl and ethyl substituted piperidines. The tubulysin conjugates further comprise a monoclonal antibody via succinimide linkers.
Patent EA-036404-B1 (EA)
Title: Pharmaceutical compositions for combination therapy
Inventor: PRUZANSKI MARK
IPC: A61K31/216
Filed: 2016-02-05
Abstract: The present invention relates to a pharmaceutical composition for the treatment or prevention of a farnesoid X receptor (FXR) mediated disease or condition, or a disease or condition related to elevated lipid levels, reducing the level of a liver enzyme, or inhibiting or reversing fibrosis, comprising therapeutically effective amounts of an FXR agonist, bezafibrate and one or more pharmaceutically acceptable carriers, wherein the FXR agonist is a compound of formula Aor a pharmaceutically acceptable salt or glycine or taurine conjugate thereof, wherein R1 is unsubstituted C1-C6alkyl; R2 is hydrogen or -hydroxyl; X is C(O)OH, C(O)NH(CH2)mSO3H, C(O)NH(CH2)nCO2H or OSO3H; R4 is hydroxyl or hydrogen; R7 is hydroxyl or hydrogen; m is 1, 2, or 3; and n is 1, 2, or 3. The invention also relates to a method of inhibiting or reversing fibrosis, comprising administering said pharmaceutical composition to a subject. The invention provides an improved therapy for the treatment of conditions involving elevated concentrations of circulating lipid compounds in the blood, such as cholesterol and triglycerides.
Patent EA-033056-B1 (EA)
Title: Method for labelling a biological tissue and device for implementation thereof
Inventor: KOLYADINA IRINA VLADIMIROVNA
IPC: A61N5/00
Filed: 2018-08-28
Abstract: The invention relates to medicine and medical equipment, more specifically, to devices for tags implantation into a biological tissue and to methods for localization of such tags in the patient's body, e.g. during surgical, diagnostic and other medical procedures. The device comprises a needle (1) presented as a tube with n-tags (3) (n=2, 3, …, N) inside it, with a handle (6) attached to one of its ends, the other end being pointed, and a rod (2) for movement inside the needle (1), one of the rod ends carries a handle (12) and the other end is adapted to press out the tags (3) contained in the needle (1). The needle handle (6) has a prolonged hollow body (9) with its front and rear parts located on different ends of the body, and the needle handle body (9) has an n-stepped opening (11) extending longitudinally along the body (9) and having a step length corresponding to the tag (3) size. The rod handle (12) at its end has a radial projection (13) located in said opening (11) and occupying the upper operating position in the needle handle body (9) rear part, and the rod handle (12) is capable of successively imparting the linear motion along the needle handle body (9) axis to the rod when the rod handle projection (13) is rail-travelling along the n-step opening (11) of the needle handle from the first operating position to the second operating position, and imparting to the rod (2) the rotational motion relative to the needle handle body (9) axis when the rod handle projection (13) is rail-travelling along the n-step opening (11) of the needle handle from the second operating position to the third operating position. The needle (1) pointed end's edge is turned and fixed relative to the n-step opening (11) guideway. The foregoing device makes it possible to implement a method for biological tissue labelling that includes the following phases. After puncturing the biological tissue, the needle (1) with n-tags (3) is brought to a required labelling site, moved to the first insertion point, in which the needle (1) movement is stopped and the first tag is pressed out by way of pressing the rod (12) handle and imparting linear motion to it. Then the needle (1) is pulled on while not fully removed from the wound, and the needle (1) insertion angle is changed, the needle (1) is moved to the next insertion point, in which the needle (1) movement is stopped and the rod handle (12) is first rotated and then pressed for imparting the linear motion to the rod (2) and pressing out the next tag (3) into the next point. The second phase is repeated where necessary, and then the needle (1) is removed from the wound. The device and the method will allow to improve the efficiency of tag insertion into a biological tissue.
Patent EA-034505-B1 (EA)
Title: Closure
Inventor: CESARE SLAVICA
IPC: B65D41/17
Filed: 2016-12-19
Abstract: A snap-on/twist off closure (22) is disclosed, a package comprises the closure, e.g., a bottle in combination with the closure. The closure includes an upper wall defining an opening and a cylindrical snap on pipe (30) depending from the upper wall. The pipe includes threads designed to mate with external threads on a neck of the bottle. The threads on the pipe and threads on the neck of the bottle pass over each other when the closure is snapped onto the bottle during manufacture. The pipe includes a resistance recess (42) and a guidance recess (70). A bottom rim of the pipe, the resistance recess and the guidance recess are in contact with a forcing element (50) on a shoulder of the bottle and guide the closure into positions permitting unscrewing of the closure.
Patent EA-038529-B1 (EA)
Title: Method for removing impurities from crude terephthalic acid particles
Inventor: ZHAO XU
Filed: 2017-05-15
Abstract: The invention relates to a method for processing an acetic acid solvent in crude terephthalic acid (CTA) in an oxidation unit of a pure terephthalic acid (PTA) industrial device. According to the invention, a filter cake in CTA is washed by means of a two-stage-three-step method. The invention further shortens the production process of solvent exchange technology of CTA pressure filters, improves the production capacity of the device, reduces the costs of the device, reduces the energy consumption of a system, and solves the shortcomings of the existing CTA solvent exchange technology of the pressure filters.
Patent ES-2184567-B1 (ES)
Title: Procedimiento para la solubilizacion de proteinas.
Inventor: CARRIO MARIA DEL MAR
IPC: C07K1/113
Filed: 2000-07-31
Granted: 2004-09-16
Abstract: Procedimiento para la solubilización de proteínas. El procedimiento de la presente invención tiene por objeto la purificación de proteínas solubles y biológicamente activas, y consiste esencialmente en la incubación de cuerpos de inclusión que contienen la proteína de interés con un extracto celular purificado. El procedimiento para la solubilización de proteínas de la presente invención comprende las etapas de: a) cultivo de células huésped que expresan la proteína de interés en forma de cuerpos de inclusión; b) lisado de dichas células huésped y extracción y purificación de los cuerpos de inclusión; y se caracteriza por el hecho de que comprende además: c) obtención de un extracto celular purificado; d) tratamiento de los cuerpos de inclusión con dicho extracto celular purificado a una temperatura adecuada; y e) aislamiento y purificación de la proteína solubilizada.
Patent ES-2242465-B1 (ES)
Title: Aparato portable de microinfusion pulsatil de hormonas basado en sistema motriz de empuje lineal tipo torpedo.
Inventor: FERNANDEZ VILAN JOSE ANTONIO
IPC: A61M5/145
Filed: 2002-08-27
Granted: 2007-02-01
Abstract: Aparato portable de microinfusión pulsátil de
hormonas basado en sistema motriz de empuje lineal tipo torpedo. 
     Este aparato comprende dos subsistemas, uno
mecánico y otro de control. 
     El subsistema mecánico se basa en un mecanismo
de empuje lineal con un micro-motorreductor (3)
embebido en un casquillo roscado que a través del tornillo (2)
desplaza el vástago de una jeringa (5). 
     El subsistema de control es de tipo realimentado
en posición mediante un codificador angular (1) y utiliza un
microcontrolador programable desde un computador externo e incorpora
mecanismos redundantes de seguridad. 
     Las reducidas dimensiones y peso del aparato
permiten su portabilidad.
Patent ES-2215471-B1 (ES)
Title: Salsa especial patatas bravas.
Inventor: PASCUAL GARCIA MARGARITA
IPC: A23L27/60
Filed: 2003-01-14
Granted: 2005-12-16
Abstract: Salsa especial patatas bravas cuyos ingredientes son: - 5 litros de mahonesa ya preparada - 100 gramos de ajos - 100 gramos de pimentón picante - 200 mililitros de ketchup - 200 centilitros de agua Todos estos ingredientes se baten y se obtiene la salsa mencionada.
Patent ES-2316211-B1 (ES)
Title: Sistema de montaje de estructuras acuaticas sobre una cimentacion de anclaje y cimentacion destinada para dicho montaje.
Inventor: TORRES MARTINEZ MANUEL
IPC: F03D13/25
Filed: 2006-01-09
Granted: 2009-12-03
Abstract: Sistema de montaje de estructuras acuáticas
sobre una cimentación de anclaje  y cimentación destinada para dicho
montaje, construyéndose la cimentación,  que consta de un bloque (3)
de hormigón en forma de casquete, mediante  hormigonado en un lugar
portuario sobre un encofrado compuesto por una  plataforma flotante
anular (1), con la cual plataforma flotante (1) se  lleva a cabo
después en transporte flotante el traslado del bloque (3)  de la
cimentación hasta el lugar de instalación en el mar, en donde desde 
la misma plataforma flotante (1) se realiza el descenso del bloque
(3)  hasta el fondo marino, sin necesidad de grúas accesorias.
Patent ES-2328201-B1 (ES)
Title: Autoconstruccion industrializada modular y climatizada por ventilacion natural.
Inventor: SARMIENTO OCAMPO JAIME ALBERTO
IPC: E04B1/19
Filed: 2007-03-30
Granted: 2010-09-15
Abstract: Autoconstrucción industrializada modular y
climatizada  por autoventilación  natural que se caracteriza
por combinar un conjunto de barras, nudos simples,  nudos complejos,
bases, tensores, cubrebarras y cubrenudos, con o sin postigos  de
ventilación, especialmente diseñados para, en combinación entre
ellos,  definir la estructura básica de una construcción, capaz de
climatizarse  a través de la ventilación natural de sus elementos y
del espacio interior  que defina, y que permita ser transportada por
medios sencillos y ensamblada  y desensamblada  in situ  con
herramientas sencillas por personas no especialmente 
cualificadas.