Patent EA-003421-B1 (EA)
Title: Method for preventing and reversing atherosclerosis in mammals
Inventor: STEWARD DUNCAN J
IPC: A61K35/14
Filed: 1999-11-15
Abstract: 1. Method in preparation of a medicament for preventing progression of atherosclerosis in a mammal, of an aliquot of the mammal's blood which has been subjected extracorporeally to an electromagnetic emission and an oxidative environment. 2. Method according to claim 1, wherein the oxidative environment comprises applying an oxidizing agent to the aliquot. 3. Method according to claim 2, wherein the oxidizing agent contains ozone gas, and the ozone gas is introduced into the blood aliquot in an amount which does not give rise to excessive levels of mutagenicity. 4. Method according to claim 2, wherein the oxidizing agent comprises a mixture of ozone gas and medical grade oxygen, the ozone gas being contained in the mixture in a concentration of up to about 300 mug/ml. 5. Method according to claim 4, wherein the ozone has is contained in the mixture in a concentration of up to about 30 mug/ml. 6. Method according to claim 4, wherein the mixture is applied to the aliquot at a flow rate of up to about 0.33 litres/min. 7. Method according to claim 1, wherein the electromagnetic emission comprises ultraviolet light having one or more UV-C band wavelengths. 8. Use according to claim 1, wherein the aliquot is further subjected to a temperature stressor, said temperature stressor comprising a temperature above or below body temperature which does not result in substantial hemolysis of the blood is the aliquot. 9. Use according to claim 8, wherein the temperature stressor is applied so that the temperature of at least part of the aliquot is in the range of from about 5 degree C to about 55 degree C. 10. Use according to claim 9, wherein the mean temperature of the blood in the aliquot is in the range of tom about 37 degree C to about 44 degree C. 11. Use according to claim 9, wherein the mean temperature of the blood in the aliquot is in the range of from about 0 degree C to about 36.5 degree C. 12. Use according to claim 9, wherein the mean temperature of the blood in the aliquot is in the range of from about 10 degree C to about 30 degree C. 13. Use according to claim 9, wherein the mean temperature of the blood in the aliquot is in the range of from about 37 degree C to about 55 degree C. 14. Use according to claim 13, wherein the temperature is 42.5 +- 1 degree C. 15. Use according to claim 1, wherein the aliquot has a volume of up to about 400 ml. 16. Use according to claim 15, wherein the volume of the aliquot is about 10 ml. 17. Use according to claim 1, wherein the aliquot is subjected to the electromagnetic emission and the oxidative environment for a period of up to about 60 minutes. 18. Use according to claim 17, wherein the aliquot is subjected to the electromagnetic emission and the oxidative environment for a period of about 3 minutes. 19. Use according to claim 8, wherein the aliquot is simultaneously subjected to the electromagnetic emission, the oxidative environment and the temperature stressor. 20. Use according to claim 1, wherein the aliquot is simultaneously subjected to the electromagnetic emission and the oxidative environment.