baber/WOPTO huggingface dataset:
Patent PT-745094-E (PT)
Inventor: SAVINO ROCCO
IPC: C07K14/54
Filed: 1995-12-13
Abstract: It is known that the ligands of the group of cytokines similar to Interleuk 6 (IL-6), that is Oncostatin M (OSM), Leukemia Inhibitory Factor (LIF), Ciliary Neurotrophic Factor (CNTF) and Interleukin 11 (IL-11), induce the formation of a receptor complex of which the membrane molecule gp 130 is a part. The present invention refers to a methodology for selecting superagonists, antagonists and superantagonists of human interleukin-6 comprising the following operations: comparing the amino acid sequence of bovine granulocyte colony stimulating factor (bG-CSF) with the sequence of said hormone; and on the basis of the above comparison, formulating a three dimensional model of said hormone, which allows the identification of residues that form the site of interaction with the specific receptor (Site 1) and those that constitute the site of interaction with gp 130 (Site 2) respectively. The invention allows the identification of these sites in human interleukin-6 and the isolation of variants having, with respect to the wild type hormone, a greater affinity for the specific receptor (superagonists and superantagonists) or affinity for gp 130 reduced or abolished (antagonists and superantagonists). A scheme illustrating the methodology applied to identify site 1 and site 2 in the case of human interleukin-6 is disclosed. The invention also describes the obtaining of specific superagonists and superantagonists of interleukin-6 and the use of superantagonists as low dose inhibitors of the growth of human myeloma cells dependent on wild type interleukin-6.
Patent PT-743307-E (PT)
Inventor: YAMADA KOICHIRO
IPC: C07D239/46
Filed: 1996-05-14
Abstract: Novel sulfonamide derivatives of the formula [I]: wherein Ring A and Ring B are substituted or unsubstituted monocyclic, bicyclic or tricyclic hydrocarbon, or substituted or unsubstituted heterocyclic group, Q is single bond, -O-, -S-, -SO-, -SO<sub>2</sub>- or -CH<sub>2</sub>-, Y is -O-, -S- or -NH-, Alk is lower alkylene or alkenylene, Z is -O - or -NH -, R is substituted or unsubstituted aromatic heterocyclic or aryl, R<sup>1</sup> is H, trifluoromethyl, substituted or unsubstituted amino, substituted or unsubstituted lower alkyl, alkenyl, alkynyl, substituted or unsubstituted lower alkylthio, or alkoxy, or substituted or unsubstituted heterocyclic or aryl, or pharmaceutically acceptable salts thereof, which are useful in the prophylaxis or treatment of disorders associated with endothelin activities such as hypertension, pulmonary hypertension, renal hypertension, Raynaud disease, bronchial asthma, gastric ulcer, chronic heart failure, etc.
Patent PT-761211-E (PT)
Inventor: IWAMOTO TARO
IPC: A61K9/22
Filed: 1996-08-22
Abstract: This invention provides a sustained release composition comprising a PLGA matrix, a bioactive agent, and a quaternary ammonium surfactant, in which the release profile of the bioactive agent from the PLGA matrix is controlled by the concentration of the quaternary ammonium surfactant.
Patent PT-819004-E (PT)
Title: Pharmaceutical composition containing proton pump inhibitors
Inventor: DAVE KAUSHIK J
IPC: A61K9/00
Filed: 1996-03-29
Abstract: The present invention is concerned with an oral pharmaceutical formulation containing a proton pump inhibitor (PPI) which is suitable for the treatment of gastric acid related diseases in man and animals. More specifically, the composition is a paste, and is particularly suitable for delivery of a proton pump inhibitor to horses.
Patent PT-832010-E (PT)
Inventor: NUYTS HENRI
IPC: B60P1/44
Filed: 1996-06-21
Abstract: Loading lift device for mounting to the container (2) of a truck (1), comprising two vertical columns (4) being provided with means for receiving sliders (6) to which a loading platform (7) is pivotably mounted. The columns (4) and sliders (6) are vertically extending formed beams comprising a plate-shaped longitudinal rib (43, 44) and stiffening ribs (38, 40, 45, 48, 50, 51, 52) extending longitudinally. The longitudinal rib extends in longitudinal direction of the container (2) and substantially parallel to its side wall (10) and extends along the accompanying column (4) or slider (6). The surfaces of the longitudinal ribs (43, 44) of column and slider (6) facing each other are provided with engaging sliding members (38, 49). Between parts of the slider (6) and the column (4), a space (9) extending in vertical direction is formed for receiving the means (8) for moving a slider (6) in relation to a column (4) in vertical direction.
Patent PT-865575-E (PT)
Inventor: BECHER ULRICH
IPC: F04C2/16
Filed: 1996-07-08
Abstract: PCT No. PCT/CH96/00250 Sec. 371 Date Feb. 8, 1999 Sec. 102(e) Date Feb. 8, 1999 PCT Filed Jul. 8, 1996 PCT Pub. No. WO97/21925 PCT Pub. Date Jun. 19, 1997In prior art designs, single-flight cast double worms with angles of contact >720 DEG  with large balance hollows at both ends and worm lengths of whole multiples of the pitch operate in the medium rotation speed ranges ( DIFFERENCE 3000 min DIFFERENCE 1) without imbalance. The desired use of special uncastable materials and the manufacturing complexity and the necessary dimensional stability even for extreme profile geometries pose additional problems in balancing which are solved by the present invention. Here, it is possible, by varying the angle of contact of the worm and any balance hollows and/or by altering the contour of the worms in the medium engagement region, to reduce the size of the balance hollows, sometimes to "zero", and with the possible use of additional masses. Besides the advantage of simple raw component manufacture, worms balanced in this way also permit the use of special materials and extreme worm geometries for fitting in pumps used in the chemical, medical and food sectors.
Patent PT-914488-E (PT)
Inventor: CARDEN ROBIN A
IPC: G11B5/84
Filed: 1997-05-21
Abstract: A rigid disk substrate for a magnetic recording disk is formed of a ceramic-metal matrix composite. A metal-cladding may be included around the ceramic-metal matrix composite to form a sandwich structure. The ceramic-metal matrix composite has a composition ranging from approximately 1 to 40 weight % of ceramic and 60 to 99 weight % of metal matrix. The metal matrix material and the metal cladding material are aluminum or an aluminum alloy.
Patent PT-896110-E (PT)
Inventor: RUECHEL FRANK DIPL ING
IPC: F16B35/02
Filed: 1998-08-06
Abstract: In a double-layer sheet-metal roof with intermediate heat insulation out of roll felts, with a sheet-metal profile support, a sealing layer disposed thereon - if required, insulation material disposed thereon, preferably in form of a roll felt out of mineral wool, and with a sheet-metal profile cover layer disposed thereabove, with spacer profiles between which the roll felts are arranged in cassette-like manner being arranged between said sheet-metal profile support and sheet-metal profile cover layer, said spacer profiles comprise web flanges spaced to said sheet-metal profile cover layer and protruding laterally, which for the purpose of mounting substantially free of heat and/or cold bridge are in knife-like or claw-like engagement through the roll felt side wall directly into the material of the roll felt having no recesses in this area.
Patent PT-969102-E (PT)
Title: Primers, kits and sets of restriction fragments used in selective restriction fragment amplification
Inventor: ZABEAU MARC
IPC: C12Q1/6858
Filed: 1992-09-24
Abstract: The invention relates to a process for the controlled amplification of at least one part of a starting DNA containing a plurality of restriction sites for a determined specific restriction endonuclease, and of which at least part of its nucleic acid is unknown. Application of this process to human, animal or plant DNA fingerprinting, to identification of restriction fragment length polymorphisms. Kit for the application of the process.
Patent PT-982301-E (PT)
Inventor: JOHNSON ROY A
IPC: C07D263/04
Filed: 1994-06-03
Abstract: of formula (I) and their salts are new: R1 = Me, phenyl (opt. substd. by 1-3 substits. from 1-4C alkyl, 1-3C alkoxy or alkylthio, halo, CF3, 2-6C dialkylamino, OH, or nitro), 2-furyl, 2-thienyl, 1- or 2- naphthyl, or 3,4-methylene-dioxyphenyl; R2 = H, NHCO, 2-11C alkanoylamido, benzamido (opt. substd. by 1-3 substits. as phenyl in R1), NHCOCMe=CHMe, NHCOOCMe3, NHCOOCH2Ph, amino, p-toluene-sulphonamido, NHCO(CH2)3COOH, NHCOC6H4-p-SO3H, OH, NHCO-1-adamantyl, NHCOO-3-tetrahydrofuranyl, NHCOO-4-tetrahydropyranyl, NHCOCH2CMe3, NHCOCMe3, 2-11C alkoxycarbamyl, 2-11C alkylureido, phenylureido (opt. substd. as phenyl in R1), 4-9C cycloalkanoylamido, NHCOCMeEt2, NHCOCMe2CH2Cl, NHCOCMe2Et, phthalimido, 1-phenylcyclopentyl-1-carboxamido, 1-methylcyclohexyl-1-carboxamido, NHCSNHCMe3, or NHCONHCMe3; R3 = H, NHCOPh, or NHCOOCMe3; provided that one of R2, R3 is H, but not both; R4 = H, OH, OAc, OCOCH2CCl3, OCOCH2CH2NH3+HCOO-, NHCOPh, NHCOOCMe3, succinyl, glutaryl, or OCO-Z-COR20; Z = CH2CH2, (CH2)3, CH=CH, 1,2-cyclohexane, or 1,2-phenylene; R20 = OH, OM, NR22R23, OR23, SR23, OCH2CONR24R25, OCO(CH2)nNR32R33, OCOCHR"NH2, prolyl, OCOCH=CH2, succinyl-taurine Na or NBu4 salt, 3-succinyl-amido-propane sulphonic acid Na or NBu4 salt, or OCOCH2CH2COOCH2CH2OH; R32, R33 = H or 1-3C alkyl; R" = H, Me, isobutyl, sec-butyl, isopropyl, benzyl, 4-aminobutyl, CH2CH2COOH, or 4-guanidinopropyl; R5 = H or OH; provided that, when R5 = OH, then R4 = H, and when R5 = H, then R4 is not H; R10 = H or Ac; and R17 = H or benzoyl (opt. substd. by 1-3 substits. from azido, cyano, methoxy, or halo. Also claimed are specified oxazolidine carboxylic esters (V), the corresp. acids (VII) and the 7-acyloxy-baccatin esters of these acids; the deacylation of specified taxol and baccatin III derivs. by reaction with hydrazine; and the prepn. of (V) by condensn. of specified serine derivs. with electron-rich benzaldehydes or acetals.
Patent SG-2289-G (SG)
Title: Derivatives of pyridinium thiomethyl cephalosporins,process for their preparation and pharmaceutical composition containing them
IPC: C07D501/36
Filed: 1989-01-11
Abstract: The present invention relates to cephalosporins of general formula: <IMAGE>   in which: R1 is H or CH3, R2 is CH3, or R1 and R2 taken together form a 1,3-propylene group, R3 is lower alkyl, alkenyl, alkynyl or CH2COO alkyl, R4 is H or OH, the S being bonded to the pyridine ring in 2 or 4 position, A is H or cation or ester or hemiacetal which is easily hydrolyzable, and X is a derivative of a mineral or organic acid. The invention also relates to a process for preparing these new cephalosporins and to the drugs containing said cephalosporins.
Patent SG-8692-G (SG)
Title: Compact disc player
IPC: G11B27/10
Filed: 1992-01-31
Abstract: 1. CD disc player, in which the starting times (T1, T2, ..., Tn) of at least one part or the program blocks contained in the contents list of a CD disc are storable in a store (S) whose storage capacity is insufficient for the maximum number of program blocks and in which among all the program blocks of the CD disc several are selectable and assemblable into a program in any sequence, characterised in that the starting times (T1, T2, ..., Tn) of the program blocks are stored in sequence in the store (S), that the numbers (P1, P2, ..., Pm) of the m program blocks assembled into a program are written into the store (S) in reverse sequence and that any storage spaces already filled with starting times are overwritten.
Patent SG-23619-G (SG)
Title: Colored thermoplastic resin composition
Inventor: BAUMGARTNER ALAN SQUIER
IPC: C09B1/16
Filed: 1986-08-20
Abstract: A colored thermoplastic resin composition is provided which comprises a thermoplastic resin and a colorant in the form of an alkyleneoxy-substituted chromophore group provided in said thermoplastic resin in a minor amount sufficient to provide coloration to said thermoplastic resin. A process for preparing colored thermoplastic resins is also provided.
Patent IE-810143-L (IE)
Title: Producing narasin
IPC: C12R1/465
Filed: 1981-01-27
Abstract: The new microorganism Streptomyces lydicus DeBoer et al., NRRL 12034 and the fermentation process for preparing narasin by submerged aerobic fermentation of this organism.
[US4309504A]
Patent IE-840243-L (IE)
Title: Hexapeptides
IPC: A61P5/02
Filed: 1984-02-01
Abstract: The invention relates to cyclic hexapeptides of the general formula III   <IMAGE>   in which X represents the radical of an L-aminoacid of the general formula IIIa    <IMAGE> (IIIa)  in which A and B are identical or different and denote alkyl having 1 to 3 carbon atoms, or A and B together represent a saturated, unsaturated or aromatic monocyclic or bicyclic structure having 3 to 6 carbon atoms, n denotes 0 or 1, and Y represents an aliphatic or aromatic L-aminoacid the side chain of which can be hydroxylated, and their salts with physiologically tolerated acids, and to a process for their preparation and their use and their intermediates.
Patent IE-38204-L (IE)
Title: Fracture fixing device
IPC: A61B17/74
Filed: 1973-03-06
Abstract: 1429633 Fracture fixing device NATIONAL RESEARCH DEVELOPMENT CORP 5 March 1973 [8 March 1972] 10793/72 Heading A5R A trachanteric fracture fixing device comprises a first elongated member 10 with two opposed major faces and having a plurality of apertures 11 spaced therealong, the member being connected at an angle to a second elongated member 14 having a plurality of flat faces (15) Fig. 1 (not shown) which converge towards its free end which has a substantially polygonal cross section the major part of the periphery of which is produced by the flat faces. The apertures may be of countersunk slot form and offset in successively opposite manner relative to the longitudinal axis of the member 10 which is concavely curved in transverse profile on the face contacting the bone 18, and relieved on the opposite face 12 of the member 10. The second member 14 may be of circular cross section form adjacent the first member 10, and thereafter is tapered by three flat faces (15) to give a triangular cross section at the free end thereof.
[GB1429633A]
Patent IE-34286-L (IE)
Title: Speed control of electric motors
IPC: G05G1/00
Filed: 1970-05-07
Abstract: A variable-resistance foot control device for regulating the speed of an electric motor is particularly useful for sewing machines. It has a casing containing the variable-resistance element and a speed selection slider. The actuating member comprises a cover which pivots on a vertical axle against the action of a return spring which is fixed between the casing and said axle. The casing has a peripheral collar which the skirt of the cover surrounds and an annular support surface provided on the inside of the cover faces the collar. The slider is carried by a hinged lever actuated by turning the foot on the cover, whereby a pin and groove mechanism pivots the lever and moves the slider into contact with the contact points on the variable-resistance element.
[US3639877A]
Patent IE-40501-L (IE)
Title: Alkyl derivatives of prostanoic acids
IPC: B01J31/00
Filed: 1974-03-21
Abstract: 15- And/or 16-alkyl derivatives of 9,15-dioxygenated prost-13-enoic, prosta-4,13-dienoic and prosta-5,13-dienoic acid, lower alkyl esters thereof and homologs thereof, as well as a process for preparing these derivatives are disclosed. The compounds possess hypotensive, anti-hypertensive, bronchospasmolytic, gastric acid secretion inhibiting, abortifacient, estrus synchronizing and ovulation regulating properties. The compounds also inhibit the aggregation of platelets and promote the disaggregation of aggregated platelets. Methods for their use are also disclosed.
[US3917668A]
Patent IE-870638-L (IE)
Title: Iron containing composition
IPC: A61K33/26
Filed: 1987-03-11
Abstract: Pharmaceutically acceptable compositions of one or more n-6 or n-3 essential fatty acids, particularly gamma-linolenic acid, dihomo-gamma-linolenic acid, or eicosapentaenoic acid, and assimilable iron compounds, in dosage unit form optionally with a diluent or carrier, said acids being present as such or as derivatives convertible in the body thereto and the amounts of said acids or derivatives being 1mg to 100g (calculated as gamma-linolenic acid) and of said iron compounds 0.1mg to 10g (calculated as iron) or submultiples of said amounts convenient for daily administration thereof.
Patent IE-850867-L (IE)
Title: Penicillins and azetidinones - stereocontrolled process.
IPC: C07D205/08
Filed: 1985-04-04
Abstract: A novel stereocontrolled process is disclosed for converting 6-aminopenicillanic acid to an optically active azetidinone of the formula <IMAGE> wherein R'' is a hydroxy-protecting group by use of a 6,6-dihaloanhydropenicillin or 6,6-bis(phenylselenyl)anhydropenicillin intermediate.
[US4596677A]
Patent IE-811097-L (IE)
Title: Alkoxy-acyl carnitines
IPC: A61K/
Filed: 1981-05-15
Abstract: A novel class of alkoxy-acyl carnitines, wherein the alkoxy-acyl radical has from 4 to 6 carbon atoms (tipically: methoxypropionyl, ethoxypropionyl and propoxyacetyl) is prepared by reacting a solution of a carnitine salt in an organic solvent with an alkoxy-acyl halogenide, thus obtaining the corresponding salt of alkoxy-acyl carnitine. By eluting an aqueous solution of this salt through a column of an ion exchange resin activated in Cl- or Br- form, the chloride or bromide of alkoxy-acyl carnitine is obtained. The alkoxy-acyl carnitines are therapeutically effective in the treatment of cardiac disorders, hyperlipidaemias and hyperlipoproteinaemias.
[US4590209A]
Patent IE-891187-L (IE)
Title: Carbocyclic compounds
IPC: A61K31/535
Filed: 1989-04-13
Abstract: This invention comprises novel carbocyclic compounds of formula I (wherein A, Z, R<1><1> and R<1><2> are defined in the specification) derived from acylsulfonamide derivatives of  alpha -carbocyclyltoluic acids wherein said compounds of formula I antagonize the actions of one or more of the arachidonic acid metabolites known as leukotrienes. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.
Patent IE-35054-L (IE)
Title: Protective coated aluminium
IPC: B05D1/38
Filed: 1970-12-31
Abstract: 1322381 Coating aluminium BRITISH ALUMINIUM CO Ltd 1 Jan 1971 [2 Jan 1970] 194/70 Heading B2E Aluminium, particularly the inside of beer kegs, has a protective coating comprising a layer comprising a mixture of a phenolic resin with an epoxy primer and a further coating of nylon 11 adhered thereto. Before application of the primer the aluminium is preferably caustic etched, chromic/sulphuric acid etched, grit blasted or subject to a chemical conversion treatment. Alternatively, an anodic film may be applied.
[GB1322381A]
Patent IE-781853-L (IE)
Title: Fluidised beds used for toughening glass
IPC: C03B27/052
Filed: 1978-09-14
Abstract: An article, for example a glass sheet, is treated in a gas-fluidized particulate material by advancing the article along a path leading into the gas-fluidized particulate material and extracting gas from a region of the path at a rate sufficient to pack the particulate material in that region and thereby obturate the path. An opening leading into a container for a gas-fluidized bed of particulate material may be obturated in this way. The packed state of the material obturating the opening is such that an article can pass through the opening.
[US4194898A]
Patent IE-872030-L (IE)
Title: Method of making a water laid fibrous web
IPC: D21H17/00
Filed: 1987-07-27
Abstract: A method of making a fibrous web containing at least two particulate materials and which includes mixing the dry particulate materials together in a substantially dry condition, using the dry mix to form at least part of an aqueous dispersion of fibres, and draining the dispersion to form a web.
Patent IE-822083-L (IE)
Title: Cholecalciferol derivatives
IPC: C07C31/42
Filed: 1982-08-27
Abstract: 1. Claims for the contracting states : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE A cholecalciferol derivative of the formula  see diagramm : EP0073465,P14,F3  1. Claims for the contracting state : AT A process for the manufacture of a cholecalciferol derivative of the formula  see diagramm : EP0073465,P16,F1  characterized by thermally isomerizing a precholecalciferol derivative of the formula  see diagramm : EP0073465,P16,F3
Patent IE-42931-L (IE)
Title: Electrolytic recovery of metal.
IPC: C25C7/06
Filed: 1975-11-14
Abstract: Apparatus and a process for electroylic recovery of silver from fixing baths obtained by development of photographic films wherein the fixing bath solution coming from the tank for the fixing bath to the development apparatus is fed from the development apparatus into one chamber in a recovery apparatus comprising two chambers until the said first chamber is filled whereupon the silver precipitation is started in the said chamber; an automatic redirection of the liquid flow from the development apparatus to the second chamber of the recovery apparatus is made to the said second chamber which being filled with liquid during the precipitation process in the first chamber. After concluded silver precipitation in the first chamber the liquid treated therein is automatically fed to the sewage. When the second chamber has been filled the precipitation process in the same is started. Simultaneously the liquid flow from the development apparatus is automatically fed to the first chamber which now is empty. When the precipitation process in the second chamber is finished the liquid is pumped through a filter - i.e. for removal of gelatine, silver bromide, etc. - from the second chamber back to the chemicals tank for re-use, whereupon the cycle is repeated.
[SE7415216A]
Patent IE-44193-L (IE)
Title: Active carbon
IPC: C01B31/12
Filed: 1976-12-17
Abstract: An improved process is disclosed whereby coal, coke or a combination thereof can be converted in good yield to a very high surface area active carbon with a unique and useful combination of properties, which carbons are particularly useful for water purification. Novel active carbons having a very high surface area which substantially have a cagelike structure exhibiting microporosity are disclosed.
[CA1071177A]