baber/WOPTO huggingface dataset:
Patent AU-2019204375-A1 (AU)
Title: Method for producing genome-modified plants from plant protoplasts at high efficiency
Inventor: KIM JIN SOO
IPC: C12N9/22
Filed: 2019-06-21
Abstract: The present invention relates to a method of increasing the production efficiency of gene-edited plants, regenerated from plant protoplasts, by use of a Cas protein-guide RNA 5 ribonucleoprotein(RNP). According to the present invention, the method of increasing the production efficiency of gene edited plants makes it possible to efficiently produce target gene-mutated plants and to minimize the introduction of foreign DNA into plants. Thus, the present invention can be 10 very advantageously used in a wide variety of fields, including agriculture, food and biotechnology.
Patent AU-2019216989-A1 (AU)
Title: CAR-T cells and autoimmune diseases
Inventor: BLUESTONE JEFFREY A
IPC: G01N33/574
Filed: 2019-02-11
Abstract: Chimeric antigen receptor (CAR)-expressing Tregs specifically target an antigen present in the joint of RA patients to induce a localized and effective immunosuppressive response.
Patent AU-2019217207-A1 (AU)
Title: Improved antagonistic anti-human CD40 monoclonal antibodies
Inventor: ADANG ANTON EGBERT PETER
IPC: C07K16/28
Filed: 2019-02-11
Abstract: The disclosure concerns antibodies that bind and antagonize CD40. These antibodies are particularly useful to inhibit immune responses and treat auto-immune diseases.
Patent AU-2019221427-A1 (AU)
Title: Apparatus and method of fraud prevention
Inventor: GARCIA CARLOS
IPC: G06Q30/06
Filed: 2019-02-12
Abstract: There is provided an apparatus and method for fraud detection such that a large number of events per second of online activity/ordering are effectively reduced to a few cases of fraud by finding patterns in fraudulent orders. According to the present invention there is provided a fraud detection unit arranged to communicate with a customer order database, a customer order history database and a fraud statistics database. The fraud detection unit comprises a training unit arranged to train a model based on customer order history information in the customer order history database and fraud statistics information in the fraud statistics database and a calculating unit arranged to calculate a probability of an order being fraudulent based on the trained model and customer order information in the customer order database.
Patent AU-2019222671-A1 (AU)
Title: System and method for dissolving solid chemicals and generating liquid solutions
Inventor: DOBIZL KENNETH THOMAS
IPC: B01F15/00
Filed: 2019-02-13
Abstract: A system (100) for dissolving solid chemical may include three reservoirs positioned in a vertically stacked arrangement. A solid chemical reservoir (102) configured to receive solid chemical to be dissolved may be nested in a solution generator reservoir (104) into which water is introduced to erode the solid chemical. A dissolved chemical reservoir (106) can be positioned under the solid chemical reservoir (102) and the solution generator reservoir (104). The dissolved chemical reservoir (106) can store solution generated using the system (100). A recirculation circuit (110) is used to recirculate water introduced into the solution generator reservoir (104) until a solution having a target concentration of the chemical being dissolved is achieved. The recirculation circuit (110) includes a recirculation line (114) having an outlet aimed at the bottom wall of the solid chemical reservoir (102).
Patent AU-2019222857-A1 (AU)
Title: Methods for producing polypeptides in protease-deficient mutants of Trichoderma
Inventor: MAIYURAN SUCHINDRA
IPC: C12N1/14
Filed: 2019-08-28
Abstract: METHODS FOR PRODUCING POLYPEPTIDES IN PROTEASE-DEFICIENT MUTANTS OF TRICHODERMA The present invention relates to mutants of a parent Trichoderma strain, comprising a polynucleotide encoding a polypeptide and one or more (several) genes selected from the group consisting of a first subtilisin-like serine protease gene, a first aspartic protease gene, a trypsin like serine protease gene, a second subtilisin-like serine protease gene, and a second aspartic protease gene, wherein the one or more (several) genes are modified rendering the mutant strain deficient in the production of one or more (several) enzymes selected from the group consisting of a first subtilisin-like serine protease, a first aspartic protease, a trypsin-like serine protease, a second subtilisin-like serine protease, and a second aspartic protease, respectively, compared to the parent Trichoderma strain when cultivated under identical conditions. The present invention also relates to methods of producing a polypeptide in such mutants and methods for producing such mutants.
Patent AU-2019226562-A1 (AU)
Title: Medical devices containing poly(butylene succinate) and copolymers thereof
Inventor: WILLIAMS SIMON F
IPC: A61L27/56
Filed: 2019-03-01
Abstract: Resorbable implants comprising poly(butylene succinate) and copolymers thereof have been developed. The implants implants are preferably sterilized, and contain less than 20 endotoxin units per device as determined by the limulus amebocyte lysate (LAL) assay, and are particularly suitable for use in procedures where prolonged strength retention is necessary, and can include one or more bioactive agents. The implants may be made from fibers and meshes of poly(butylene succinate) and copolymers thereof, or by 3d printing, and the fibers may be oriented. Coverings and receptacles made from forms of poly(butylene succinate) and copolymers thereof have also been developed for use with cardiac rhythm management devices and other implantable devices. These coverings and receptacles may be used to hold, or partially/fully cover, devices such as pacemakers and neurostimulators. The coverings and receptacles are made from meshes, webs, lattices, non-wovens, films, fibers, and foams, and contain antibiotics such as rifampin and minocycline.
Patent AU-2019258326-A1 (AU)
Title: Powderous composition comprising carotenoid and/or derivative thereof, D-glycose oligomere and modified polysaccharide as well as food, feed or personal care formulation comprising the composition
Inventor: BULBARELLO ANDREA
IPC: A23L2/58
Filed: 2019-04-24
Abstract: The present invention relates a powderous formulation comprising at lease one polyunsaturated fatty acid (and/or derivative thereof), which can be produced easily and which can be used in many fields of application. The powderous composition comprises (i) up to 70 weight-% (wt-%), based on the total weight of the powderous composition, of at least one polyunsaturated fatty acid, and (ii) 5 - 30 wt-%, based on the total weight of the powderous composition, of at least one D-glycose oligomer (preferably a maltodextrin) (G01) having a DE of < 18, and (iii) 5 - 30 wt-%, based on the total weight of the powderous composition, of at least one D-glycose oligomer (preferably a maltodextrin) (G02) having a DE of > 18, and (iv) 5 - 70 wt-%, based on the total weight of the powderous composition, of at least one modified polysaccharide. A food, feed and personal care formulation comprising at least one powderous composition is also claimed.
Patent AU-2019266511-A1 (AU)
Title: New quinoline derivatives
Inventor: Hübsch Walter
IPC: C07D405/14
Filed: 2019-05-07
Abstract: The present invention covers new quinoline compounds of general formula (I), in which A, R
Patent AU-2019271932-A1 (AU)
Title: A power supply box for use with an architectural-structure covering
Inventor: KOVACH JOSEPH E
IPC: H05K7/14
Filed: 2019-11-26
Abstract: OF THE DISCLOSURE 
A power supply unit (200) for use with one or more motorized architectural-structure 
coverings (100) is disclosed. In one example of an embodiment, the power supply unit (200) 
includes one or more features to simplify installation. For example, in one embodiment, the 
power supply unit (200) does not require an installer to access an internal compartment of the 
power supply unit (200). In addition, and/or alternatively, in one embodiment, a cable (260) 
extending between the power supply unit (200) and the motorized architectural-structure 
covering (100) include same gender connectors (265) for facilitating easier installation and 
reducing installation errors. In one embodiment, the power supply unit (200) includes a 
power connector (240) accessible through an outer surface thereof for receiving line-voltage 
and a plurality of low-voltage connectors (250, 252) accessible through the outer surface for 
supplying low-voltage to a plurality of motorized architectural-structure coverings (100).  
(FIG. 1)
1/5 
100 
110I270 
265 
264 6 
250, 
252 
r 26O 265 
FIG.1
Patent AU-2019275659-A1 (AU)
Title: Methods of treatment of diseases in which IL-13 activity is detrimental using anti-IL-13 antibodies
Inventor: TIMONY GREGG
IPC: A61K39/395
Filed: 2019-12-06
Abstract: METHODS OF TREATMENT OF DISEASES IN WHICH IL-13 ACTIVITY IS DETRIMENTAL USING ANTI-IL-13 ANTIBODIES The present invention is directed to methods for treating diseases in which IL-13 activity is detrimental, including eosinophilic esophagitis (EoE) and asthma, by administering to a subject in need of such treatment, a composition containing an interleukin-13 (IL-13) antibody, or an antigen binding fragment, thereof.
Patent AU-2019294262-A1 (AU)
Title: Electrically heated reactor and a process for gas conversions using said reactor
Inventor: VAN DER PLOEG GOVERT GERARDUS PIETER
IPC: C01B3/38
Filed: 2019-06-25
Abstract: The present invention relates to a reactor configuration comprising at least one electrically heated furnace which defines a space, with at least one reactor tube placed within the furnace space and said reactor tube having an exit and entrance outside of the reactor furnace, and wherein said furnace is further provided with - at least one electrical radiative heating element suitable for heating to high temperatures in the range of 400 to 1400 °C, said heating element being located inside said furnace in such a way that the heating element is in no direct contact with the at least one reactor tube; and; and - a number of inspection ports in the furnace wall such to be able to visually inspect the condition of the at least one reactor tube on each opposite side of said reactor tube during operation, the total number of inspection ports being sufficient to inspect all reactor tubes present in the furnace at their full length and circumference; and wherein the heating duty of the furnace is at least 3 MW. The process being electrically heated demands a heat- flux and temperature profile. In many applications the heat-flux is larger when the process enters the furnace whilst having a lower temperature. Towards the exit the heat-flux is lower whilst having higher temperature. The present invention can accommodate this requirement. The reactor is useful in many industrial scale high temperature gas conversion and heating technologies.
Patent AU-2019297198-A1 (AU)
Title: Composition and method for treating pain
Inventor: KARELIS HARRY
IPC: A61P25/04
Filed: 2019-07-03
Abstract: The invention relates to pharmaceutical compositions comprising Δ
Patent AU-2019319868-A1 (AU)
Title: Force-indicating retractor device and methods of use
Inventor: JARAMAZ BRANISLAV
IPC: A61B34/20
Filed: 2019-08-07
Abstract: Devices, systems, and methods for measuring a force applied to a joint during a surgical procedure are disclosed. The device includes an insertion tool, a handle, and one or more force indicators. The insertion tool includes an insertion end and a base end. The one or more force indicators may be attached to the insertion tool and the handle. The insertion end of the device may be inserted into a joint during a surgical procedure and used to apply a force to the joint and/or measure the force using the one or more force indicators when the force is applied.
Patent AU-2019351797-A1 (AU)
Title: Inter-frequency mobility support for communication systems with dynamic spectrum assignments
Inventor: CHEN ETHAN Y
IPC: H04W16/14
Filed: 2019-09-26
Abstract: Systems and methods for enabling inter-frequency user equipment mobility in shared spectrum communication systems. One example system (100) includes a communication interface (315) coupled to an electronic processor (305). The electronic processor (305) is configured to, for each of a plurality of base stations, determine a location for the base station. The electronic processor (305) is configured to select at least one handover candidate from the plurality of base stations based on the location and at least one base station characteristic. The electronic processor (305) is configured to determine a channel allocation. The electronic processor (305) is configured to generate, based on the channel allocation of the at least one handover candidate, a neighbor channel list (380). The electronic processor (305) is configured to transmit the neighbor channel list (380) via the communication interface (315).
Patent AU-2019359771-A1 (AU)
Title: Barcoding of nucleic acids
Inventor: JASPER MELINDA
IPC: C40B50/06
Filed: 2019-10-16
Abstract: The present disclosure relates to methods, kits and products for barcoding of nucleic acids. In certain embodiments, the present disclosure provides a method of producing nucleic acid for sequencing utilising clonal amplification on a solid substrate, the method comprising: (a) providing a nucleic acid sample for sequencing; (b) amplifying the nucleic acid sample using an amplifying primer comprising a degenerate nucleotide sequence and a 5' fixed nucleotide sequence, to produce amplified nucleic acids; and (c) further amplifying the amplified nucleic acids with (i) a first primer comprising the 5' fixed nucleotide sequence and a first adapter nucleotide sequence, and (ii) a second primer comprising the 5' fixed nucleotide sequence and a second adapter nucleotide sequence, wherein the first adapter nucleotide sequence or the second adapter nucleotide sequence provides a sequence for subsequent priming of DNA synthesis from a nucleotide sequence attached to the solid substrate and the other adapter nucleotide sequence provides a sequence for subsequent priming of DNA synthesis from a template produced from the subsequent priming, and wherein one or more of the first primer, the second primer and the amplifying primer comprise a specific identifier sequence to identify nucleic acids amplified with the first primer, the second primer and/or the amplifying primer; thereby producing nucleic acid for sequencing utilising clonal amplification on the solid substrate.
Patent AU-2019373093-A1 (AU)
Title: Hydrogen-based battery
Inventor: ZHAO CHUAN
IPC: C25B1/04
Filed: 2019-10-29
Abstract: Disclosed herein are batteries and methods of making batteries. The batteries disclosed herein generally comprise a cathode, an electrolyte capable of conducting protons and/or hydronium ions, and an anode comprising a material capable of absorbing protons and/or hydronium ions, wherein (i) the cathode is in contact with a cathode substance, or (ii) the electrolyte comprises a reduced cathode substance, or (iii) the cathode is in contact with a cathode substance and the electrolyte comprises a reduced cathode substance, and wherein the cathode substance is an oxide of one or more metals or an oxide of a halide.
Patent AU-2019375825-A1 (AU)
Title: Macrocyclic tyrosine kinase inhibitor and uses thereof
Inventor: LIU BIN
IPC: A61K31/519
Filed: 2019-11-08
Abstract: The present invention belongs to the technical field of medicine, and relates to a macrocyclic tyrosine kinase inhibitor and the uses thereof. Specifically, the invention relates to a compound of general formula (I) or a pharmaceutically acceptable salt, ester or stereoisomer thereof, a preparation method therefor, a pharmaceutical preparation or pharmaceutical composition containing same, and medical uses thereof.
Patent AU-2019378108-A1 (AU)
Title: Extracellular vesicles for replacement of urea cycle proteins and nucleic acids
Inventor: HEAN JUSTIN
IPC: C12N9/88
Filed: 2019-11-18
Abstract: The present invention relates to engineered extracellular vesicles (EVs) as a novel therapeutic approach to treating urea cycle disorders. More specifically, the invention relates to the use of various protein engineering and nucleic acid engineering strategies for improving loading of urea cycle proteins or nucleic acids encoding urea cycle proteins into EVs and targeting of the resultant EVs to tissues and organs of interest.
Patent AU-2019385477-A1 (AU)
Title: Functionalized heterocycles as antiviral agents
Inventor: Panarese Joseph
IPC: A61K31/473
Filed: 2019-11-20
Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
Patent AU-2019404202-A1 (AU)
Title: Semi-autonomous system for carrying and placing elongate objects
Inventor: CHABALA JOSEPH E
IPC: E04G21/00
Filed: 2019-12-19
Abstract: An improvement to a semi-autonomous apparatus (10) is described herein. In an apparatus having a gantry subassembly (100), a tram subassembly (200) movably mounted on the gantry subassembly (100), and an actuation subassembly (300) mounted on the tram subassembly (200), the improvement includes a gripper subassembly (400) operatively connected to the actuation subassembly (300). The movement of the subassemblies is controlled in part by a control system that controls drive systems associated with one or more of the subassemblies. The gantry subassembly (100) includes a bridge member (102) for laterally spanning a selected section of a work site. The tram subassembly (200) includes a tram (202) that travels laterally along to the bridge member (102). The actuation subassembly (300) includes at least one motion actuator for controlling the movement of the gripper subassembly (400) in a generally vertical direction and may include an additional motion actuator for movement in a generally horizontal direction. The gripper subassembly (400) includes passively actuated grippers (402) for lifting, transporting and placing objects (52, 54), and particularly, elongate objects such as reinforcing bars used in road and other cementitious surface construction.
Patent AU-2019473414-A1 (AU)
Title: Generated hydrogen gas lift system
Inventor: GRECI STEPHEN MICHAEL
IPC: E21B43/12
Filed: 2019-11-07
Abstract: A variety of systems, methods and compositions are disclosed, including, in one method, a method for producing a subterranean formation, the method comprising: introducing a reactive material into a wellbore penetrating the subterranean formation; hydrolyzing the reactive material with an aqueous-based wellbore fluid to produce hydrogen gas; reducing a bulk density of the aqueous based wellbore fluid; producing the wellbore. A system for producing a wellbore, the system comprising: an oilfield tubular disposed in a producing wellbore; a fluid column comprising an aqueous based wellbore fluid within the oilfield tubular, wherein the fluid column comprises a hydrostatic head greater than a pore pressure of the wellbore; and a solid reactive material capable of chemically reacting with the aqueous-based wellbore fluid thereby reducing the hydrostatic head.
Patent AU-2020200418-A1 (AU)
Title: Generating cell-free DNA libraries directly from blood
Inventor: SRINIVASAN ANUPAMA
IPC: C12Q1/68
Filed: 2020-01-21
Abstract: The disclosure provides methods and kits for preparing sequencing library to detect chromosomal abnormality using cell-free DNA (cfDNA) without the need of first isolating the cfDNA from a liquid fraction of a test sample. In some embodiments, the method involves reducing the binding between the cfDNA and nucleosomal proteins without unwinding the cfDNA from the nucleosomal proteins. In some embodiments, the reduction of binding may be achieved by treating with a detergent or heating. In some embodiments, the method further involves freezing and thawing the test sample before reducing the binding between the cfDNA and the nucleosomal proteins. In some embodiments, the test sample is a peripheral blood sample from a pregnant woman including cfDNA of both a mother and a fetus, wherein the methods may be used to detect fetal chromosomal abnormality such as copy number variation. In other embodiments, the test sample is a peripheral blood sample from a patient known or suspected to have cancer, wherein the methods can be used to detect chromosomal abnormalities in the cfDNA of the patient. Kits for detection of copy number variation of the fetus using the disclosed methods are also provided.
Patent AU-2020200872-A1 (AU)
Title: Game token management system
Inventor: SHIGETA YASUSHI
IPC: A63F1/06
Filed: 2020-02-06
Abstract: According to the present invention, there is provided a management system that prevents misuse of many game tokens during the operation of casino using card game tables in casino and other card game facilities using card game tables. The management system has a function that previously registers IDs of contemplated game tokens on database, manages IDs of game tokens present on a game table chip tray and a storage together with information on location on database, specifies the game token in the game table chip tray and the storage at predetermined timing, and generates an error signal when the following statuses is noticed: 1) a fact that ID absent on database is newly present and 2) a fact that two or more identical IDs are present. C) L 60' UC-
Patent AU-2020201277-A1 (AU)
Title: Methods for increasing forced expiratory volume in asthmatics using benralizumab
Inventor: WARD CHRISTINE
IPC: G01N33/48
Filed: 2020-02-21
Abstract: Provided herein is are methods of increasing forced expiratory volume in one second (FEV 1) in an asthma patient, comprising administering to the patient an effective amount of benralizumab or an antigen-binding fragment thereof.
Patent AU-2020203113-A1 (AU)
Title: Anti-complement C1s antibodies and uses thereof
Inventor: VAN VLASSELAER PETER
IPC: A61K39/395
Filed: 2020-05-12
Abstract: The present disclosure provides antibodies that bind complement CIs protein; and nucleic acid molecules that encode such antibodies. In some embodiments, such anti complement CIs antibodies inhibit proteolytic activity of CIs. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions.
Patent AU-2020203358-A1 (AU)
Title: Novel micro-dystrophins and related methods of use
Inventor: CHAMBERLAIN JEFFREY S
IPC: C07H21/04
Filed: 2020-05-22
Abstract: Nucleotide sequences including a micro-dystrophin gene are provided. The micro-dystrophin genes may be operatively linked to a regulatory cassette. Methods of treating a subject having, or at risk of developing, muscular dystrophy, sarcopenia, heart disease, or cachexia are also provided. The methods may include administering a pharmaceutical composition including the micro-dystrophin gene and a delivery vehicle to a subject. Further, the methods may include administering the pharmaceutical composition a subject having Duchenne muscular dystrophy or Becker muscular dystrophy.
Patent AU-2020203531-A1 (AU)
Title: Compositions for pulmonary delivery of long-acting muscarinic antagonists and long-acting b2 adrenergic receptor agonists and associated methods and systems
Inventor: VEHRING REINHARD
IPC: A61K9/12
Filed: 2020-05-29
Abstract: Compositions, methods and systems are provided for pulmonary delivery of long acting muscarinic antagonists and long-acting P2 adrenergic receptor agonists via a 5 metered dose inhaler. In particular embodiments, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.