Patent SG-11201903031T-A (SG)
Title: Techniques for heart muscle remodeling using a cardiac pacemaker and related systems and methods
Inventor: MEYER MARKUS
IPC: A61N1/365
Filed: 2017-10-06
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property C.--.` Organization 3 MD HIM 0 11101 HOE 3E1 0 01110110011111111111011 OE 11110 ill OEN International Bureau (10) International Publication Number (43) International Publication Date ......°' WO 2018/067931 Al 12 April 2018 (12.04.2018) WIP0 1 PCT (51) International Patent Classification: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, A61N 1/36 (2006.01) A61N 1/37 (2006.01) HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, A61N 1/362 (2006.01) A61N 1/375 (2006.01) KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, A61N 1/365 (2006.01) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (21) International Application Number: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, PCT/US2017/055536 SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (22) International Filing Date: (84) Designated States (unless otherwise indicated, for every 06 October 2017 (06.10.2017) kind of regional protection available): ARIPO (BW, GH, (25) Filing Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (26) Publication Language: English UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (30) Priority Data: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 62/404,908 06 October 2016 (06.10.2016) US MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (71) Applicant: THE UNIVERSITY OF VERMONT AND KM, ML, MR, NE, SN, TD, TG). STATE AGRICULTURAL COLLEGE [US/US]; 85 South Prospect Street, Burlington, VT 05405 (US). Published: (72) Inventor: MEYER, Markus; 516 Wildlower Circle, — with international search report (Art. 2 I (3)) Williston, VT 05495 (US). (74) Agent: MORRIS, James, H.; Wolf, Greenfield & Sacks, = P.C., 600 Atlantic Avenue, Boston, MA 02210-2206 (US). = _ (81) Designated States (unless otherwise indicated, for every — kind of national protection available): AE, AG, AL, AM, = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (54) Title: TECHNIQUES FOR HEART MUSCLE REMODELING USING A CARDIAC PACEMAKER AND RELATED = SYSTEMS AND METHODS = 400 (57) : According to some aspects, a cardiac pacemaker for implan- --_, tation within a subject is provided, the pacemaker including a housing, at least = = — —= 142 Identify Period of Subject Inac ivity one sensor configured to detect an activity level of the subject, and at least one processor coupled to the sensor configured to detect inactivity of the subject based on output from the at least one sensor, produce a first signal configured — = to increase the heart rate of the subject to a first heart rate during a first time period, wherein the first heart rate is above a resting heart rate and below 100 = = = 404 Apply Interstitial Remodeling Stimulus at First Elevated Heart Rate beats per minute, and in response to determining that the first time period has elapsed, producing a second signal configured to increase the heart rate of the subject to a second heart rate during a second time period, wherein the second heart rate is between 100 and 140 beats per minute. = — Il .4 4116 Determine if Volume Increase Stimulus has been applied within the current ti me window Il No Yes C en IN CZ ,-.... MI Apply Volume Increase ,1Q STOP GC Il Stimulus at Second Elevated Heart Rate CZ r'l r I r• A C