baber/WOPTO huggingface dataset:
Patent CR-20150447-A (CR)
Title: Nuevos derivados de pirazol
Inventor: GRETHER UWE
IPC: C07D487/04
Filed: 2015-08-27
Abstract: La invención se refiere a un compuesto de la fórmula (I): en la que de A1 a A3 y de R1 a R3 tienen los significados definidos en la descripción y en las reivindicaciones. El compuesto de la fórmula (I) puede utilizarse como medicamento.
Patent CR-20160515-A (CR)
Title: Escalera adaptada para el uso como una escalera simple o una escalera de extensión
Inventor: TAMEZ REYES FRANCISCO JAVIER
IPC: E06C1/54
Filed: 2016-11-07
Abstract: Un aparato de escalera tiene una primera sección de escalera que tiene un par de rieles laterales y una pluralidad de peldaños que se extienden entre los rieles laterales, una segunda sección de escalera conectada en forma articulada con la primera sección de escalera contigua a un extremo superior de la primera sección de escalera y un mecanismo de cerrojo fijo a una de las secciones de escalera y que se puede engranar con la otra de la primera y segunda secciones de escalera.
Patent CR-20210307-A (CR)
Title: Novel benzylamino substituted pyridopyrimidinones and derivatives as sos1 inhibitors
Inventor: KOFINK CHRISTIANE
IPC: C07D519/00
Filed: 2018-12-20
Abstract: The present invention encompasses compounds of formula (I) wherein the groups R1 to R4, A and p have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
Patent CR-20230166-A (CR)
Title: Anti-hla-dq2.5 antibody and its use for the treatment of celiac disease
Inventor: IKAWA YURI
IPC: C07K16/28
Filed: 2021-09-17
Abstract: The present invention relates to anti-HLA-DQ2.5 antibodies and its use for the treatment of celiac disease. The present invention provides anti-HLA-DQ2.5 antibodies that have been modified. The anti-HLA-DQ2.5 antibodies of the invention have binding activity to complexes formed by HLA-DQ2.5 and a gluten peptide, but have substantially no binding activity to complexes formed by HLA-DQ2.5 and an irrelevant peptide. Furthermore, the antibodies of the invention are shown to have inhibitory effects on T cell activation by gluten peptides.
Patent EC-SP045018-A (EC)
Title: Uso de compuestos en un inhalador de polvo seco
IPC: A61K31/46
Filed: 2004-03-12
Abstract: La presente invención se refiere a una formulación de inhalación que comprende un compuesto seleccionado entre una clase particular de 5,6-dihidro-9H-pirazolo [3,4-c]-1,2,4-triazolo [4,3-a] piridinas, que es capaz de liberar el compuesto en forma de partículas sólidas finas en el pulmón, y al uso de tal formulación en el tratamiento de ciertas enfermedades tales como las enfermedades respiratorias. Por medio del uso de tales formulaciones es posible eliminar la respuesta de tos indeseada asociada con el uso de estos compuestos en inhaladores de dosis medida de solución, pudiendo afectar negativamente tal respuesta a la administración de una dosis terapéuticamente eficaz y, a largo plazo, impedir el cumplimiento del tratamiento por parte del paciente.
Patent EC-SP077920-A (EC)
Title: Dispositivo de ensayo
Inventor: CHAFFEY JASON
IPC: G01N33/48
Filed: 2007-11-20
Abstract: Un dispositivo de ensayo (1) que tiene una plataforma rotatoria (2) con una cámara de prueba (6) y un sensor (20) que sufre un desplazamiento cuando se somete a la presencia de una sustancia particular tal como un espécimen químico, biológico u otro organismo. El sensor es una varilla voladiza (21) con una sección porosa (23) para mejorar la sensibilidad.
Patent EC-SP088189-A (EC)
Title: Derivados de 3-sulfonilindazol sustituido comoligandos de 5-hidroxitriptamina-6
Inventor: MCDEVITT ROBERT EMMETT
IPC: C07D231/56
Filed: 2008-02-15
Abstract: La presente invención suministra un compuesto 3-sulfonilindazol de fórmula Ien dondeX es O, S, NR, CH2, CH2Y, CH2Z, CO, CONR o NRCO;Y es O, S o NR;Z es CO;n es 0 o un entero de 1, 2, 3, 4, 5 o 6 cuando X es CH2; n es un entero de 1, 2, 3, 4, 5 o 6 cuando X es CH2Z, CO o NRCO;n es un entero de 2, 3, 4, 5 o 6 cuando X es O, S, NR, CH2Y o CONR;R es H o un grupo alquilo opcionalmente sustituido;R1 es H o un grupo alquilo, cicloalquilo, arilo o heteroarilo cada uno opcionalmente sustituido;R2 es un grupo alquilo, cicloalquilo, arilo o heteroarilo opcionalmente sustituidos un sistema de anillo bicíclico o tricíclico de 8- a 13- miembros opcionalmente sustituido que tiene un átomo N en el cabezal del puente y opcionalmente contiene 1, 2 o 3 heteroátomos seleccionados entre N, O o S;R3 y R4 son cada uno independientemente H, o un grupo alquilo opcionalmente sustituido;R5 y R6 son cada uno independientemente H, o un grupo alquilo, alquenilo, alquinilo, cicloalquilo, cicloheteroalquilo, arilo o heteroarilo cada uno opcionalmente sustituido, o R5 y R6 pueden ser tomados juntos con el átomo al cual ellos están ligados para formar un anillo de 3- a 7- miembros opcionalmente sustituido que contiene opcionalmente un heteroátomo adicional seleccionado entre O, N o S;R7 es H, halógeno, CN, OR8, CO2R9, CONR10R11, o un grupo alquilo, alquenilo, alquinilo, cicloalquilo, cicloheteroalquilo, arilo o heteroarilo cada uno opcionalmente sustituido;m es un entero de 1, 2 o 3;R8 es H, COR12 o un grupo alquilo, alquenilo, alquinilo, arilo o heteroarilo cada uno opcionalmente sustituido;R9 es H o un alquilo C1-C6, o un grupo arilo o heteroarilo cada uno opcionalmente sustituido;R10 y R11 son cada uno independientemente H o un grupo alquilo opcionalmente sustituido; yR12 es un grupo alquilo C1-C6, cicloalquilo, cicloheteroalquilo, arilo o heteroarilo; oun estereoisómero del mismo o una sal farmacéuticamente aceptable del mismo.	La presente invención también suministra métodos y composiciones útiles para el tratamiento terapéutico de trastornos del sistema nervioso central relacionados con o afectados por el receptor 5-HT6.
Patent FI-20041002-A (FI)
Inventor: PUKARI MIKA
IPC: E05B47/06
Filed: 2004-07-19
Abstract: The invention relates to an electronic lock and its operating method. In the lock according to the invention, a key is identified electrically. The electric energy required by the identification is produced by a generator (130) powered by the movement of the lock cylinder. If the key is identified, the electric coupling of the generator is changed so that an actuator (150) connected to the generator guides a detent bar (190) of the lock past a detent (111) belonging to the lock body (110), after which the lock can be opened mechanically by a key (180).
Patent FI-20120140-A (FI)
Inventor: KANTOLA MAURI
IPC: E01C19/08
Filed: 2012-04-26
Abstract: Method and apparatus (10) for filling Joints or cracks in road surfaces with hot bitumen (21) or rubberised bitumen. According to the method, heated air or compressed air is utilised to keep a bitumen dosing tube (24) hot and/or to clean, dry and/or heat up a joint or a crack in the road surface prior to hot bitumen being dosed into it.
Patent FR-1595385-A (FR)
IPC: F17C3/02
Filed: 1968-12-19
Granted: 1970-06-08
Abstract: 1,206,250. Storing liquefied gases. BRIDGESTONE EKIKA GAS K.K. 5 Dec., 1968 [26 Dec., 1967], No. 57907/68. Heading F4P. A tank for storing liquefied gases comprises a rigid outer vessel 1, against the inner surface of which is a heat insulating layer 2, the inner surface of which is covered by a thin film portion 4 of an inner vessel 3 divided into a number of closed chambers by at least one rigid partitions 5, 6 to which the portions 4 are attached, the portion 4 being pressed against the insulating layer 2 by gas pressure inside the vessel 3. To allow for thermal contraction the partitions 5, 6 may slide in fittings 15 and the portions 4 may be fluted and along the edges, have curves of possibly thickened material. The tank may be used in a ship in which case the outer vessel may comprise in part the ships hull.
Patent FR-1604414-A (FR)
Title: Adjustable pig stripper/cleaner
IPC: A22B5/08
Filed: 1968-12-17
Granted: 1971-11-08
Abstract: Pig stripper/cleaner follows the scouring routine as the pigs travel on a bracket conveyor and are exposed to blades moving up and down on endless carrier chains. These blades adjust in groups either side of the pigs, spaced by pig size interval. This saves space, raises output and efficiency. The thin steel blades can be interchanged within the groups as required for particular pig sizes or arrangements.
Patent FR-1604962-A (FR)
Title: 1,2,3,4,7,7-hexachlorbicyclo (2,2,1)hept-2-ene-5,6 - -bis hydroxymethylene sulphite - for use in bird repellent compsns
IPC: C07D327/10
Filed: 1966-01-12
Granted: 1972-06-26
Abstract: Title cpd. of formula: may be used in seed dressings to protect seeds from birds.
Patent GB-1050209-A (GB)
IPC: H04N5/52
Abstract: 1,050,209. Automatic gain control. SONY CORPORATION. Aug. 4, 1964 [July 17, 1963], No. 31046/64. Heading H3T. To provide A.G.C. in a transistor amplifier an auxiliary transistor has the A.G.C. voltage applied to vary its emitter/collector impedance, and the stray capacitance which shunts this impedance is balanced out, e.g. by adding an inductor to provide a parallel resonant circuit at the operating frequency or by adding a neutralizing capacitor. In Fig. 1 an I.F. signal from 1 is applied to the collector of the auxiliary transistor 7, the base of which is controlled by the A.G.C. signal 10. The output from the emitter, which depends on the impedance through the transistor, and hence on the A.G.C. voltage, is passed on to a conventional I.F. amplifier stage 2 incorporating a neutralizing capacitor 6. An inductor 13 and blocking capacitor 14 resonates with the stray capacitance 18 to maintain the impedance high at signal frequencies. In an alternative circuit (Fig. 5, not shown) the input signal is applied through a transformer with tapped secondary, and the capacitance is balanced out by passing on an equal and opposite signal through a neutralizing capacitor so that the effect is independent of frequency. NPN transistors can be used (Figs. 6 and 7, not shown). In the arrangement of Fig. 8 (not shown), the auxiliary transistor 7 forms the emitter load of the amplifier 2, the A.G.C. signal 10 being applied to the base through a filter comprising inductors 24 and 26, capacitors 27 and 28, and diode 23.
Patent GB-1050594-A (GB)
IPC: G03C1/10
Abstract: 1,050,594. Organo-phosphite sensitized silver halide emulsions. ILFORD Ltd. June 19, 1964 [July 3, 1963], No. 26406/63. Heading G2C. Silver halide emulsions are sensitized by adding 5 to 500mg. per mole of silver in the emulsion, of an organic phosphite of formula P(OR 1  ) (OR 2  ) (OR 3 ), wherein R 1 , R 2  and R 3  are each alkyl, aralkyl or aryl groups, to a silver halide emulsion which is free from developing agent in a quantity sufficient to effect development, and containing labile sulphur compounds, added prior to, or during, the digestion of the emulsion. Specified colloids are gelatin and polyvinyl alcohol. Suitable labile sulphur compounds are sodium thiosulphate and thiourea, but gelatin may contain sufficient naturally occurring labile sulphur compounds. In the Examples a sulphur sensitized silver iodobromide emulsion is sensitized with (1) triphenyl phosphite, (2) trimethyl phosphite, (3) diphenyl isodecyl phosphite, (4) di-isodecyl phenyl phosphite, and (5) di-(nonylphenyl) phenyl phosphite.
Patent GB-1054143-A (GB)
IPC: F25D13/06
Abstract: 1,054,143. Refrigerating. WHEELABRATOR CORPORATION. April 9, 1965 [April 29, 1964], No. 15205/65. Heading F4H. A refrigeration system for producing a stream of cold air to be used to cool moulded articles comprises a primary refrigerant circuit which includes a source of liquid refrigerant 10, a liquid receiver 18, a pump 22 for forwarding liquid from the receiver in parallel through the tube sides 128 of heat exchangers 26, 26a and lines 30, 34 for returning refrigerant to source 10, and a secondary air circuit which includes the shell sides of heat exchangers 26, 26a, lines 66, 88 for supplying cold air to a working chamber 122, an impeller 54 for returning the air to the heat exchangers and a by-pass line 64 extending between the impeller outlet and line 66 for regulating the temperature of the air supplied to chamber 122. In the latter moulded rubber or plastic articles carried by a conveyer 91 (Fig. 2, not shown) are subjected to the air so that unwanted projecting parts are rendered brittle by freezing and are removed by bombardment with particulate material, entrained matter being removed from the returning air in a dust collector 82 before passing to impeller 54 via a blower 84 and line 60. The temperature of the returning air is sensed by an element 100 in chamber 122 and signalled to a control unit 108. The latter may control a valve 62 in bypass line 64, a valve 58 in a line 56 extending between the inlet and outlet of impeller 54, a valve 32 in the refrigerant return line 30 or a control 94 for source 10. When the temperature required in chamber 122 is relatively high, the primary refrigerant circuit is closed down and air for the chamber 122 is drawn from an enclosure 132 surrounding the chamber under the control of valve 80. This air is cooled by an auxiliary mechanical refrigeration unit 134. The liquid receiver 18 is stated to provide a reserve for use when the demand for liquid refrigerant is higher than can be satisfied by source 10. Defrosting.-Tubes 128 of heat exchangers 26, 26a may be defrosted separately or simultaneously by closing valve 28 and/or 28a in return line 30, closing valve 50 and/or 50a in air supply line 52 and supplying warm air to one or both heat exchangers through valve 48 and/or 48a, the warm air being discharged through valve 46 and/or 46a.
Patent GB-1054190-A (GB)
IPC: G11B25/10
Abstract: 1,054,190. Testing crease stiffness of material. C. F. TAYLOR (ELECTRONICS) Ltd. March 9, 1965 [Dec.10, 1963], No.48828/63. Heading G1S. A crease stiffness tester (see Fig. 1) comprises a beam 1 pivoted at 2, means to hold a piece of sheet material 5 in a distorted condition so that the force it exerts in seeking to return to its undistorted condition moves the beam out of balance, and means 3 to counterbalance the beam 1. The other end of the beam 1 is connected by a chain 6 to a block 7 slidably mounted on a column 8 positioned adjacent a scale 9. In use, as the sheet 5 tries to attain its undistorted condition it exerts a force on the beam to unbalance it, causing a block 10 to engage contacts 10a to operate a light 11. The block 7 is subsequently moved down the column until the weight of the chain balances the beam 1 and the light is extinguished. The reading on the scale 9 being indicative of the force exerted by sheet 5. In a modification, the beam is centrally pivoted and the counterbalance is omitted. In this embodiment, the members 6-9 are replaced by a piston submerged in a cylinder of mercury. In a further arrangement, the sheet 5 is positioned at the opposite end of the beam 1 to the counter weight 3, and any unbalance of the beam due to the force exerted by the sheet 5 is measured by variations in pressure detected on a monometer. In a still further arrangement, see Fig. 4, the beam 1 is replaced by a framework, pivoted at 2, the arms of which are counter-balanced by two weights 3. Two rods 19 are provided to form a steelyard, weights 18 being moved along the rods 19 to determine the force of displacement. Alternatively a steelyard and a calibrated chain (see Figs. 5-7, not shown) may be provided to measure the force.
Patent GB-1054335-A (GB)
IPC: B65D1/02
Abstract: 1,054,335. Closures for collapsible tubes. UNIVERSAL METAL PRODUCTS Ltd. June 8, 1965 [June 5, 1964], No. 23369/64. Headings B8D and B8T. A collapsible tubular container of a thermoplastic material such as plasticized P.V.C. or of metal comprises, as shown, tubular body 1 of thermoplastic, a shoulder portion 2 and a nozzle 3 integral with the shoulder portion, the nozzle being integrally attached by a thinwalled tube 4 to a closure 5 which may be detached by cutting the tube 4 to open the nozzle, inverted and then replaced so that a plug 7 recloses the nozzle. In a modification, Fig. 3 (not shown), for a metal collapsible tube, the tube shoulder 8 terminates in a neck 9 which has an external annular groove 10 into which an annular rib on the inner wall of the plastics nozzle 11 snaps.
Patent GB-1226405-A (GB)
IPC: F22B1/18
Filed: 1968-05-08
Abstract: 1,226,405. Tube walls; boilers. FOSTER WHEELER CORP. 8 May, 1968 [7 June, 1967], No. 21831/68. Headings F4A and F4B. In a vapour generator 10 which includes a combustion chamber 14, a tube bank section 16 having a screen tube zone 18, and a flue section 20 provided with an economizer 22, the screen tube zone 18 comprises individual tube elements 64 joined together by fins into integral tube panels 66 that are staggered to form gas passages 68, heat shielding means (70, Fig. 3) being mounted on each of the said panels 66. The heat shielding means (70) include refractory panels (72) on each of tube panels 66, such that the panels 72 are positioned between the combustion chamber 14 and the outer surfaces of the panels 66 which are co-extensive with the chamber 14.
Patent GB-1227352-A (GB)
IPC: C07D307/79
Filed: 1967-01-26
Abstract: 1,227,352. Fluorinated benzofurans; fluorophenols and derivatives thereof; valeric acid. IMPERIAL SMELTING CORP. (N.S.C.) Ltd. 12 March, 1968 [26 Jan., 1967], No. 3974/67. Heading C2C. The invention comprises compounds of the general formula wherein each X substituent is halogen, alkyl, alkoxy or nitro, at least 2 X substituents being fluorine. The compounds are prepared by reacting a compound of the general formula with more than one equivalent of butyl-lithium and then with C0 2 . The compound I wherein all the X groups are fluorine may be subjected to the following reaction scheme the conditions for which are (i) reduction with sodium borohydride, and (ii) dehydration with phosphorus pentoxide. 2,3,4,5 - Tetrafluorophenoxyacetic acid, used as a starting material in the above synthesis, is obtained by reacting potassium 2,3,4,5-tetrafluorophenate with ethyl chloroacetate and subjecting the ethyl 2,3,4,5 -tetrafluorophenoxyacetate product to acidic hydrolysis. The potassium 2,3,4,5-tetrafluorophenate is obtained (as a dihydrate) by reacting 1,2,3,4-tetrafluorobenzene with butyl-lithium, adding trimethyl borate and then hydrogen peroxide to give 2,3,4,5.tetrafiuorophenol which is converted to the salt by reaction with potassium hydroxide. An alternative synthesis described comprises reacting 2,3,4,5-tetrafluorophenol with butyllithium and CO 2  to give valeric acid and 6- hydroxy - 2,3,4,5 - tetrafluorobenzoic acid; the latter acid is converted to its ethyl ester by reaction with ethanol and H 2 SO 4 ; this ester is reacted with ethyl bromoacetate to give ethyl 6 - ethoxycarbonyl - 2,3,4,5 - tetrafluorophenoxyacetate which is reduced and cyclized with sodium hydride to give 2-ethoxycarbonyl-3- hydroxy - 4,5,6,7 - tetrafluorobenzo - (6) - furan; treatment of this compound with sodium hydroxide gives 4,5,6,7-tetrafluoro-2,3-dihydrobenzo-{6)-furan-3-one, The compounds of the invention are stated to have utility as fungicides and insecticides.
Patent GB-1228226-A (GB)
IPC: B65G15/34
Filed: 1968-11-16
Abstract: 1,228,226. Laminated conveyer belting. DUNLOP CO. Ltd. 13 Nov., 1969 [16 Nov., 1968], No. 54476/68. Heading B5N. [Also in Division B8] Conveyer belting comprises a flexible polymeric composition 2, e.g. of natural rubber and reinforcement embedded within the composition such that the reinforcement extends parallel to the surface of the belting and extends throughout the length of the belting, the reinforcement comprising a first reinforcement component 4 and a second reinforcement component 5, 6 between said first component and the load carrying surface of the belting, the first component being a layer of high modulus material providing resistance to transverse compressive loads and extending over at least part of the width of the belting and the second component being a layer of fabric having a high tensile strength in the longitudinal direction and a low compressive resistance in a direction transverse to the longitudinal direction whereby tensile forces applied to the belting ends produces transverse compression of the second component so that the belting curves and takes up a troughlike form. The first component may comprise a layer of flexible steel cords arranged at right angles to the length of the belting and closely and uniformly spaced along the length thereof or it may comprise two strips 10 of parallel, rubberized steel cords arranged transversely to the length of the belting. In alternative embodiments, the first component may comprise hard rubber, glass fibres, glass fabric, chopped steel strands or monofilaments formed from nylon, a polyester or polyvinyl alcohol. The second component may comprise a layer of fabric cut so that in the belting the warp and weft thereof each lie at an acute angle to the centre-line of the belting; alternatively, it may comprise two superimposed layers of substantially parallel filaments, e.g. of nylon, the parallel filaments of each layer lying at an acute angle to the longitudinal centreline of the belting such that parallel filaments of one layer are inclined to one side of said centre-line and the parallel filaments of the other layer are inclined to the other side of said centre line.
Patent GB-1233209-A (GB)
IPC: F16H48/30
Filed: 1968-09-06
Abstract: 1,233,209. Four-wheel drives. ZKL ZAVODY NA VALIVA LOZISKA A TRAKTORY NARODNI PODNIK. 6 Sept., 1968 [9 Sept., 1967], No. 42518/68. Heading B7H. [Also in Division F2] A toothed clutch, spring-engaged upon meshing alignment of the clutch teeth, is provided between a drive wheel 1 and a shaft 5 for transmission of drive to the front wheels of a motor vehicle, particularly a tractor, having all wheels driveable. The clutch comprises teeth respectively on the wheel 1 and a clutch sleeve 3 slidably splined on the shaft 5. The clutch is controlled by a latchable member 15 which acts, through a bell-crank lever 14, on a lever 13 having a peg engaging a slot in the end of a drawbar 10. Nested, pre-stressed, return and engaging springs 11, 12 surrounding the draw-bar about one end thereof and respectively abut a fixed plate 17 and a pin 9 through which the draw-bar passes. The pin 9 is rotatably mounted in an arm 8 connected through a shaft (6) with a fork 4 engaging, by pads (7), the clutch sleeve 3. Movement of the pin 9 is limited by engagement with the sides of a cut-out in a fixed member 16. In operation, the member 15 is raised from its clutch disengaged position shown and latched in an upper position, the return spring 11 then being compressed in readiness for clutch disengagement. Should the clutch teeth be aligned, meshing engagement is effected immediately; however, should the ends of the clutch teeth clash, the engaging spring 12, being then compressed, presses the clutch sleeve 3 against the wheel 1 until alignment is achieved, by vehicle movement, whereupon the clutch teeth are spring pressed into mesh.