Patent CA-3102078-A1 (CA)
Inventor: MILLER PAUL F
IPC: A61P1/16
Filed: 2019-05-31
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY  (PCT) CORRECTED VERSION (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date              WO 2019/232415 A8 05 December 2019 (05.12.2019) WIPOIPCT (51) International Patent Classification:                                     (72) Inventors: MILLER, Paul, F.; 39 Emerald Glen Lane, A 61K 31/404 (2006.01)           A61K 35/74 (2015.01) Salem, CT 06420 (US). ISABELLA, Vincent, M.; 38 A61P 7/06 (2006.01)              A61P 11/00 (2006.01) Holton Street, Medford, MA 02155 (US). FALB, Dean; A61P 9/00 (2006.01)              A 61P 35/00 (2006.01) 180 Lake Street, Sherborn, MA 01770 (US). KOTULA, Jonathan, W.; 2315 Sixth Street, Berkeley, CA 94710 (21) International Application Number: (US). DAGON, Yossi; 18 Pilgrim Road, Ashland, MA   01721 (US). (22) International Filing Date: 31 Ma 2019 (31.                             (74) Agent: CLARKE, Marcie, B. et al.; McCarter & English, y                                      05.2019) LLP, 265 Franklin Street, Boston, MA 02110 (US). (25) Filing Language:                  English (81) Designated States (unless otherwise indicated, for every (26) Publication Language:             English kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (30) Priority Data: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 62/679,772       02 June 2018 (02.06.2018) US    DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, HN, (71) Applicant: SYNLOGIC OPERATING COMPANY,    HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, INC. [US/US]; 301 Binney Street, Suite 402, Cambridge, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MA 02142 (US).                                                                MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (54) Title: BACTERIA ENGINEERED TO TREAT LIVER DISEASE FIG. 1A Thioacetamide (TAA) S   xid a tive stress . =    ;;;;:;;;.;;;;;3;3;:::--airtmai 1                                                     Decreased Apoptosis ureagenesis .......... ..IgniM Fibrosis aw:-mar-                                      Increased levels of ammonia in the circulation OC kr) ci (57) Abstract: The disclosure provides genetically engineered bacteria that are capable of reducing excess anunonia and converting fn ammonia and/or nitrogen into alternate byproducts. The invention also provides pharmaceutical compositions comprising the genetically rl engineered bacteria, and methods of modulating and treating disorders associated with excess ammonia and inflammation in the gut and ON the liver, including, for example, hepatic encephalopathy, NASH/NAFLD, HCV, and Huntington's disease, in a subject, comprising 11 administering the engineered bacterium to the subject. [Continued on ner t page] Date Recue/Date Received 2020-12-01 s C, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: ¨    as to applicant's entitleinent to apply for and be granted a patent (Rule 4.17(ii)) ¨    as to the applicant's entitleinent to claiin the priority of the earlier application (Rule 4.17(iii)) Published: ¨    with international search report (Art, 21(3)) (48) Date of publication of this corrected version: 15 October 2020 (15.10.2020) (15) Information about Correction: see Notice of 15 October 2020 (15.10.2020) Date Recue/Date Received 2020-12-01