Patent SG-11201900490W-A (SG)
Title: Diacylglycerol acyltransferase 2 inhibitors
Inventor: BOEHM MARKUS
IPC: C07D401/14
Filed: 2017-08-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 22 February 2018 (22.02.2018) WIP0 I PCT IiiimmomiolollmonoloomunommilooiniovoimIE (10) International Publication Number WO 2018/033832 Al (51) International Patent Classification: CO7D 401/14 (2006.01) A61P 3/00 (2006.01) A61K 31/506 (2006.01) (21) International Application Number: PCT/IB2017/054862 (22) International Filing Date: 09 August 2017 (09.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/377,137 19 August 2016 (19.08.2016) US (71) Applicant: PFIZER INC. [US/US]; 235 East 42nd Street, New York, NY10017 (US). (72) Inventors: BOEHM, Markus; 6 Goose Lane, Mansfield, MA 02048 (US). CABRAL, Shawn; 66 Latham Street, Groton, CT 06340 (US). DOWLING, Matthew S.; 1 Pryus Court, Old Lyme, CT 06371 (US). FUTATSUGI, Ken- taro; 10 Faxon Avenue, Apt. 808, Quincy, MA 02169 (US). HUARD, Kim; 34 Thatcher Street, Medford, MA 02155 (US). LEE, Esther Cheng Yin; 23 Westminster Street, Apt. 2, Somerville, MA 02144 (US). LI, Qifang; 173 Daw- ley Drive, Stonington, CT 06378 (US). LONDREGAN, Allyn T.; 26 Chapel Road, Barrington, RI 02806 (US). POLIVKOVA, Jana; 7 Pequot Avenue, Mystic, CT 06355 (US). PRICE, David A.; 66 Belknap Street, Concord, MA 01742 (US). (74) Agent: WALDRON, Roy F.; PFIZER INC., 235 East 42nd Street, MS 235/9/S20, New York, NY 10017 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) (54) Title: DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS co O R 2 D i ksi IR 1 CAr N „D 2 H O (57) : Compounds of Formula (I) that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein. R 3 (I)