baber/WOPTO huggingface dataset:
Patent UY-29588-A1 (UY)
Title: Moduladores de quinasas con estructuras de alquilquinolina y alquilquinazolina
Inventor: TUMAN ROBERT W
IPC: A61K31/395
Filed: 2006-06-08
Abstract: La invención se refiere a compuestos con estructura de alquilquinolina y alquilquinazolina de Fórmula I: donde R1, R2, R3, B, Z, G, Q y X son como se los definió aquí, al uso de tales compuestos como moduladores de proteína tirosina quinasas en particular inhibidores de FLT3 y/o c-Kit y/o TrKB, al uso de tales compuestos para reducir o inhibir la actividad de quinasa de FLT3 y/o c-Kit y/o TrKB en una célula o un sujeto, y al uso de tales compuestos para prevenir o tratar en un sujeto un trastorno de proliferación celular y/o trastornos relacionados con FLT3 y/o c-Kit y/o TrkB. La presente invención se refiere además a composiciones farmacéuticas que comprenden los compuestos de la presente invención y a métodos para tratar afecciones tales como cánceres y otros trastornos proliferativos celulares.
Patent UY-29778-A1 (UY)
Title: Nueva asociación entre la agomelatina y un inhibidor de recaptura de noradrenalina y composiciones farmacéuticas que la contienen.
Inventor: MOCAER ELISABETH
IPC: A61P25/20
Filed: 2006-08-31
Abstract: Nueva asociación entre la agomelatina y un inhibidor de recaptura de noradrenalina y composiciones farmacéuticas que la contienen.
Patent AT-515336-A1 (AT)
Title: Vermeidung oxidativer Prozesse und oxidativem Stress
IPC: A61K31/4425
Filed: 2014-02-03
Abstract: Die Erfindung betrifft eine Zusammensetzung zur Prophylaxe oder Behandlung von oxidativem Stress und den aus oxidativem Stress resultierenden Schäden, Erkrankungen und Zuständen, wobei die Zusammensetzung mindestens ein quaternäres Benzophenanthridinalkaloid (QBA) enthält, vorzugsweise ausgewählt aus der Gruppe bestehend aus Sanguinarin, Chelerythrin und deren Salzen.
Patent ES-180133-A1 (ES)
Title: UNA INSTALACIoN PARA EL TRABAJO DE LAS SUPERFICIES DE LOS VIDRIOS DE oPTICA
Filed: 1947-10-14
Abstract: Instalación para el trabajo de las superficies de los vidrios de óptica caracterizada especialmente por los puntos siguientes tomados separadamente o en combinación: a) Los casquetes esféricos de las muelas poseen dimensiones tales que vienen a recubrir la zona central del esbozo desbordando el esbozo en la región opuesta todo ello dejando las otras regiones del mismo descubiertas. b) La guía del esbozo se consigue por medio de tres rodillos cuyos ejes son paralelos y situados a igual distancia de un eje central. c) Los rodillos se hallan montados de manera que podrán ser alejados o aproximados al eje central para así adaptarlos al diámetro del esbozo. d) Las muelas se accionan individualmente mediante un motor fijo sobre un platillo estando los dos platillos articulados el uno sobre el otro de manera que podrán hacer variar e1 ángulo de los ejes de rotación de las muelas en relación con el eje central del guia o eje óptico de la lente a obtener. e) Las graduaciones previstas sobre la mesa que soportan dichos platillos permite proceder a la regulación de la inclinación de los ejes de las muelas sobre dicho eje óptico previo a la puesta en marcha de las muelas. f) Una de las muelas se somete a la acción de un dispositivo por ejemplo de muelle para ejercer una presión conveniente sobre el esbozo la acción de dicho muelle pudiendo ser anulada por ejemplo por medio de un gancho obrando en sentido contrario del muelle. g} Se utiliza una serie de pares de muelas para efectuar las distintas operaciones conductivas a la lentes a obtener especializado cada par de muelas a una de las fases determinadas del trabajo el paso de un par de muelas al siguiente efectuándose por medio de un chasis provisto de cierto número de esbozos dicho chasis corredizo de manera que permite desplazar un esbozo que se está trabajando por un par de muelas por el esbozo que se está trabajando por el par de muelas precedente.
Patent ES-193859-A1 (ES)
Title: Un arma para lanzar proyectiles
Filed: 1950-07-03
Abstract: Arma para lanzar proyectiles autopropulsados que comprende un tubo cañón abierto por la parte posterior un mecanismo disparador un cerrojo de fijación del proyectil al cañón del arma y un dispositivo mecánico de percusión y rearme automático por la acción directa de los gases de autopropulsión sobre el gatillo portapercutor caracterizada por el hecho de que este gatillo es apto para liberar al producirse el disparo el cerrojo de fijación que retiene el proyectil en el arma cerrojo que es a su vez apto para ser retirado manualmente por medio de por lo menos un órgano exterior al mecanismo de percusión.
Patent ES-262276-A1 (ES)
Title: Process for refining silicon and ferrosilicons and resultant products
IPC: C01B33/06
Filed: 1960-11-08
Abstract: Liquid Si is refined by injecting into it SiF or a compound capable of liberating SiF at the reaction temperature, i.e. 1300-1600 DEG C. The preferred compound is sodium silico fluoride although according to one example aluminium fluoride is used. The compound may be injected as a gas, a gaseous suspension of finely divided solid or in briquetted form. The compound may also be decomposed prior to injection. A refractory oxide, e.g. silica, may be injected simultaneously with the compound to thicken the resultant slag.ALSO:Liquid FeSi is refined by injecting into it SiF or a compound capable of liberating SiF at the reaction temperature i.e. 1300-1600 DEG C. The preferred compound is sodium silico fluoride although according to one example aluminium fluoride is used. The compound may be injected as a gas, a gaseous suspension of finely-divided solid or in briquetted form. The compound may also be decomposed prior to injection. A refractory oxide, e.g. silica, may be injected simultaneously with the compound to thicken the resultant slag.
Patent ES-270951-A1 (ES)
Title: Olefin polymerization process
IPC: C08F10/00
Filed: 1961-10-05
Abstract: Polymers of ethylene, and copolymers of ethylene and another 1-olefin, are made by first contacting the monomeric material with a chromium oxide polymerization catalyst in which at least a portion of the chromium is in the hexavalent state, in the presence of a liquid hydrocarbon diluent, and at a temperature below the temperature at which the polymer formed dissolves in the diluent, and secondly, contacting the particulate polymer and additional monomeric material to a further polymerization reaction at a temperature such that substantially all the polymer formed is soluble in the diluent, and recovering the polymer. The polymer and diluent are recovered by conventional methods. The 1-olefin may be propylene, 1-butene, isobutylene, 1-pentene, 1-hexene, 4-methyl-1-pentene, and 1-octene. The whole polymerization is preferably effected in a continuous manner by using a loop-shaped reactor, and a flow diagram of such a process is included in the Specification. Specification 790,195 is referred to.
Patent ES-271153-A1 (ES)
Title: Process for the manufacture of p-hydroxybenzoic acid
IPC: B01J3/04
Filed: 1961-10-11
Abstract: P-hydroxybenzoic acid is produced by reacting potassium phenolate with CO2 at 180 to 210 DEG C. under a pressure of 2 to 6 atmospheres gauges in a non-reactive atmosphere, the non-reactive gas being continuously removed from the reaction vessel and, after being cooled, being recycled through the reaction mixture to the reaction vessel. The process may be conducted by introducing potassium phenolate into an autoclave and pressing-in CO2 and a non-reactive gas, e.g. N2, so that the pressure is held at 1-2 ats. gauge until the beginning of reaction. CO2 together with N2 is conducted through a gas circulating system which leads from the autoclave to a cooler and back into the autoclave, the total pressure in the autoclave being increased slowly to 5.6 ats. gauge. By varying the speed of the circulating gas and the effectiveness of the cooler the temperature in the autoclave can be kept constant. The phenol formed by the reaction is driven out of the reaction vessel with the circulating gas and separated in the cooler. The CO2 consumed during the reaction is continuously replaced. In some circumstances the cooling effect of the gas on re-entering the reaction vessel is too great so that the mixture of CO2 and non-reactive gas must be preheated after the separating of the phenol by an adjustable preheater.
Patent ES-279532-A1 (ES)
Title: Furnace wall arrangement
IPC: F22B29/06
Filed: 1962-07-26
Abstract: A forced-flow, once-through vapour generator, particularly one operating at supercritical pressure, has furnace lining tubes which extend vertically in parallel relationship between inlet and outlet headers 54, 60 and 58, adjacent tubes being connected together over the height of the combustion chamber 10 by welding or as shown (Fig. 5) by elements 86 to which the tubes are welded. A vertical panel of similarly connected tubes 29 forms a partition in the combustion chamber, the tubes 29 extending in parallel between inlet and outlet headers 40, 42. At full load, when the generator operates as a once-through, forced-flow system, the working medium flows serially through an economizer 32 in a rear gas pass 14, the partition tubes 29, rear gas pass wall-lining tubes 47 which may be interconnected as shown in Fig. 5 and then to the wall-lining tubes of the combustion chamber. From the outlet header 58 into which the latter tubes discharge, the working medium flows through superheating surfaces 70, 80 before flowing to a turbine 82. A reheating stage 84 is disposed in a lateral gas pass 12. At part load a recirculating pump 90 draws part of the working medium from the header 58 and delivers it into a mixing vessel 36 for recirculation through the heating surfaces together with the through-flow also delivered to the mixing vessel 36 by a feed pump 30. Recirculation of the working medium serves to prevent temperature unbalance and stresses in the wall panels which might lead ultimately to fatigue failure. The four walls of the combustion chamber are welded together or to connecting elements at the four corners to form a gas-tight easing which may be suspended by hangers 93 at the upper end. In modification, Fig. 1 (not shown), the outlet header for the tubes forming a partition in the combustion chamber is connected directly to the inlet headers for the wall lining tubes.
Patent ES-344955-A1 (ES)
Title: Wired broadcasting systems and apparatus therefor
IPC: H04H20/82
Filed: 1967-09-12
Abstract: A wired broadcasting system comprising a distribution feeder having a plurality of pairs 5, 6 and 7 of conductors, on each pair of which a channel or programme is transmitted and a number of subscriber stations 10 each connected by a single individual pair of signal conductors 9 to an individual connection unit 8 adapted to connect the signal conductors to a selected pair of conductors of the feeder under the remote control of the subscriber station. The connection units may incorporate reed or ferreed switches or transistor or diode gates. The control signal from the subscriber station to the connection unit may be electrical, mechanical, pneumatic or hydraulic. In one form (Fig. 2, not shown), the two signal conductors are enclosed in an outer conductive screen constituting a third conductor. To select one of six programmes the subscriber sets a switch to apply a D.C. potential between a selected pair of these conductors. Depending on the polarity of this potential and the particular conductors involved a corresponding relay located at the connection unit and connected between those conductors, through an appropriately poled diode is energized. In another form (see Division H1) a disc carrying a magnet is rotated, by mechanical linkage such as a Bowden cable or an electric, pneumatic or hydraulic motor, to a position in which the magnet closes a selected pair of reed switches to connect in the required channel.
Patent ES-345546-A1 (ES)
Title: Self-cleaning gas oven
IPC: F24C15/20
Filed: 1967-09-28
Abstract: A gas fired oven is heat cleaned by heating the cavity to beyond the normal temperature of operation, and utilizing the heat derived from the hot exhaust gases to attain the high temperatures required. The air required for combustion and to heat clean a cooking oven is delivered by a fan 19a through a rotary regenerator 5, the gases exhausted from the oven by a second fan 19 passing through the other side of the regenerator 5. The burner in the oven may be non-aerated, or it may be wholly or partially aerated. The fans 19, 19a and the regenerator 5 may continue to run after the gas supply is shut off. The oven may have more than one burner, and the inlet and outlet passages 15, 13 the fans 19, 19a are mounted in a housing at the rear of the oven, the exhaust gases delivering over the cooker top-plate. The regenerator 5 is cylindrical and may be of rolledup corrugated material of honeycomb design Fig. 3 and may comprise asbestos, asbestos impregnated with sodium silicate or ceramic. The seals 12 are of glass fibre.
Patent ES-351689-A1 (ES)
Title: Improvements in or relating to Compositions Containing Choline Chloride
IPC: A23K1/16
Filed: 1968-03-16
Abstract: A process for preparing a dry, free-flowing, non-hydroscopic composition containing choline-chloride comprises preparing, in an aqueous choline-chloride solution, a finely-divided alkali metal salt of a fatty acid and subsequently drying the resultant mixture. Preferably the composition contains 0À25 kg. of fatty acid alkali metal salt per kg. of choline-chloride, and may be prepared by adding the desired fatty acid to a vigorously stirred aqueous choline-chloride solution and subsequently adding sodium or potassium hydroxide such that the pH is adjusted to about 8. The fatty acids desirably contain 14-20 carbon atoms.
Patent ES-354150-A1 (ES)
Title: Refractory tank structure for floating glass on molten metal
IPC: C03B18/16
Filed: 1968-05-21
Abstract: In the manufacture of flat glass by the " float " process the tank structure is lined with an alumino-silicate refractory comprising 40 to 80% by weight alumina, and from 20 to 55% by weight silica and having evenly distributed pores of uniform size distribution linear over the range 0.02 to 100 Á. It is preferred that the refractory contains not more than 1% of alkali, expressed as oxide and less than 1%, preferably less than 0.5%, of iron oxide expressed as Fe 2 O 3 . As shown the lining 9-12 of the side and end walls extends above the surface of the level of molten metal. The refractory chosen does not exhibit undesirable glass forming properties with elements present in the molten metal bath, e.g. sodium which has entered from the glass. The porous refractory is advantageous when a negative pressure is applied to an interspace between the lining blocks 9-12 and the outer casing 5-8 of the tank.
Patent ES-363959-A1 (ES)
Title: Halocolchicine derivatives
IPC: A01N45/02
Filed: 1969-02-22
Abstract: Novel compounds (I): wherein R1 is a mono-, di- or tri-haloacyl radical containing 2 to 10 carbons and R2 is MeO, MeS, MeSO, MeSO 2 or NR3R4 (R3 is alkyl and R4 is H or alkyl), are obtained: (a) by acylating corresponding compounds in which R1 is H (b) by introducing a 2-methyl radical and/or an R2- substituent into a corresponding compound not containing said radical and/or substituent, and/ or into the corresponding isocolchicine compound, e.g. methylation of corresponding 2- and/or 4-hydroxy compounds (c) by reacting methyl mercaptan with a corresponding compound wherein R2 is MeO or OH, or with the corresponding isocolchicine compound, and, if desired, oxidizing the thioether (I) so obtained (d) by reacting an amine, NHR3R4, with a corresponding compound in which R2 is MeO or OH, or with the corresponding isocolchicine compound and (e) by replacing halogen in the substituent R1 by another halogen. Desacetyl - N - chloroacetyl - colchiceine is prepared by the interaction of desacetylcolchiceine and chloracetyl chloride the N- bromoacetyl compound is prepared utilizing bromoacetyl chloride. Desacetyl 14 - desmethoxy -14 - dimethylaminocolchicine is prepared by the interaction of desacetyl-colchicine and dimethylamine. Pharmaceutical preparations showing antimitotic, cytostatic and/or gout healing action contain as active ingredient compounds (I) administration is parenterally, enterally or topically.
Patent ES-366683-A1 (ES)
Title: Migration imaging
IPC: G03G13/22
Filed: 1969-04-30
Abstract: A migration imaging method uses an imaging member comprising a layer of migration material spaced apart from at least one surface, but contacting, a softenable layer, and comprises softening the softenable layer and applying a non-electrostatic migration force so that imagewise migration of said material occurs depthwise in said layer. Specifically either (a) the migration material is magnetizable, the migration force is an imagewise magnetic field and the softenable layer is uniformly softened by liquid, vapour and/or heat, or (B) the migration force is a uniform gravitational, centrifugal or magnetic force, and the softenable layer is either imagewise hardened by uv. exposure before softening the unhardened areas, or imagewise softened by heat or contamination by a voltaile component. The image may be viewed, optionally after transferring the imaged softenable layer or separating the migrated and non-migrated material (e.g. by stripping or abrasion). Alternatively, (a) if the migration material is photo-conductive the imaged member may be used as a xeroprinting plate, (b) the migration image may be used as a mask in the subsequent exposure of the softenable layer (as in divisional Specification 1,273,384 or substrate which may be photo-hardenable, photoconductive or a diazotype material, the layer or substrate then being developed, (c) the migration image is used as a magnetic image or (d) the migration image undergoes imagewise reaction with the substrate or a surface layer.
Patent ES-367185-A1 (ES)
Title: Method of reshaping and ion-exchanging glass
IPC: C03C21/00
Filed: 1969-05-13
Abstract: A molded glass article is produced by pressing a body of molten glass which is sufficiently hot to be electrically conductive between two complementary mold parts to produce an article of a required shape, and passing an electric current through the glass between solid electrically conductive electrodes in direct contact with the molded faces of the glass to impart a desired surface characteristic to at least one of the molded faces of the glass.
Patent ES-372549-A1 (ES)
Title: Process and apparatus for the continuous manufacture of glass sheet
IPC: C03B18/06
Filed: 1969-10-15
Abstract: The width-controlling members 4 of a floatglass apparatus incorporate a slit 7 to which negative or positive gas pressure (preferably nitrogen or other non-oxidizing gas) can be applied to reduce friction and minimize edge distortion of the glass ribbon. In addition suction may be applied through the material (preferably porous graphite 15) of the widthcontrolling member to prevent lateral shrinkage of the glass. Coolant is admitted to the metal box 9.
Patent ES-376046-A1 (ES)
Title: New carbamic and thiocarbamic acid esters, the production and use
IPC: C07C239/00
Filed: 1970-01-30
Abstract: Pharmaceutical compositions, having bactericidal and fungicidal activity suitable for oral or tropical administration, contain novel carbamates or thiocarbamates of the formula I wherein R 1 is a phenoxy radical substituted by at least one and at most three identical or different halogen atoms of the symbols R 2 , R 3 and R 4 at least one is Cl or Br, the others each are H, Cl, or Br R 5 and R 7 each are H, halogen, C 1-4 alkyl, C 1-4 alkoxy C 1-4 haloalkyl, NO 2 or OH R 6 is H, halogen, C 1-4 alkyl, C 1-4 alkoxy, di-(C 1-4 alkyl) amino or OH and X is O or S in admixture with suitable carriers. The compositions may also contain further active ingredients such as antibacterial and/or antimycotic substances, for example, halogenated salicylic acid alkyl amides and anilides, halogenated diphenylureas, halogenated benzoxazoles, or benzozozolones, polychlorohydroxy-diphenylmethanes, 2-iminoimidazolidines, 2-iminotetrahydropyrimidines, dithiocarbamic acid derivatives, such as tetramethylthiuram disulphide, or bactericidal quaternary compounds. Disinfectant compositions comprise the above novel compounds dissolved in rinse bath solutions. Organic material or manufactured articles such as synthetic resins, paper, paints, textiles, wood or leather are protected from attack by microorganisms by applying to said microorganism an antimicrobially effective amount of one of the above novel compounds.
Patent ES-376311-A1 (ES)
Title: Cathode-ray tube provided with at least one electron gun for producing a number of individually prefocused electron beams
IPC: H01J29/50
Filed: 1970-02-06
Abstract: In a colour television tube of the shadow mask type wherein three co-planar beams pass at different radial positions through a common focusing/converging lens, the pre-focusing effect of electrodes preceding the common lens is weaker for the outer beams than for the centre beam to compensate for the stronger focusing effect of the common lens on the outer beams. In Fig. 3 the three cathodes 6-8 are aligned with respective apertures in the first three grids 9, 30 and 34, and the pre-focusing effect of these electrodes is increased for the centre beam by the bulge in the centre of the second grid 30. In a modification, Fig. 2 (not shown), the second grid (13) is flat and the central aperture in the third grid (17) is smaller than the two outer apertures. The main lens comprises electrodes 24 and 25, and the third grid 34 is provided with an annular bulge 28 having the same diameter as the end portion 26 of the fourth grid. If the three guns have independent electrodes the required differences in pre-focusing may be achieved by using different potentials on the electrodes of the various guns.
Patent ES-379615-A1 (ES)
Title: Hull form of a ship provided with a cylindrical bow
IPC: B63B1/04
Filed: 1970-05-13
Abstract: According to the invention the hull of the ship has at its bow a substantially cylindrical configuration at the full-load line and the configuration of a forwardly projecting fin at the ballast line. The upper portion of the forwardly projecting fin has the configuration of a convex ridge providing a transition between the cylindrical portion and forwardly projecting portion of the fin which is beyond the convex ridge configuration of the upper fin portion.
Patent ES-390634-A1 (ES)
Title: Extended life secondary cells
IPC: H01M6/50
Filed: 1971-04-27
Abstract: The useful shelf and cycle life of secondary cells using a zinc anode, and a azobisformamide or substituted azobisformamide depolarizer is increased by coating the zinc with a small amount of a tetraalkylammonium salt, and/or increasing the content of ammonium chloride in the electrolyte above its solubility limit.
Patent ES-403946-A1 (ES)
Title: Glass-making tool and method of use
IPC: G01P15/13
Filed: 1972-06-16
Abstract: An accelerometer for measuring the acceleration of a body in any direction with extremely high sensitivity and accuracy, utilizing a mass which is free to move incrementally in any direction but which is then returned to a stable position by means of a servo-controlled electromagnetic field.
Patent ES-413500-A1 (ES)
Title: Channel cloth slitter
IPC: D06H7/04
Filed: 1973-04-09
Abstract: There is disclosed an apparatus for slitting or separating a channel cloth backing between pile rows thereof, incorporating rotary knives or fixed blades and means for guiding the channel cloth during cutting.
Patent ES-417959-A1 (ES)
Title: Polyvinyl chloride compositions containing trixylyl phospate and a second plasticizer
IPC: C08L27/00
Filed: 1973-08-17
Abstract: A sheet or film of a vinyl chloride resin composition suitable for outdoor agricultural purposes is prepared by blending a trixylyl phosphate stabilizer with a vinyl chloride.