Patent RU-2182909-C2 (RU)
Inventor: FREDERIK KHRISTIAN GRENVALL
IPC: A61P13/02
Filed: 1996-06-21
Granted: 2002-05-27
Abstract: FIELD: organic chemistry, steroids, biology. SUBSTANCE: invention relates to steroids of sterol order of the general formula (I)   where R 1  and R 2  are taken independently among the group including hydrogen atom and unbranched or branched C 1 -C 6 -alkyl; R 3  is taken among the group including hydrogen atom, methylene, hydroxy-group, oxo-group, =NOR 26  where R 26  means hydrogen atom and hydroxy-group and C 1 -C 4 -alkyl bound with the same carbon atom of sterol skeleton; or R 3  in common with R 9  or R 14  mean additional bond between carbon atoms with that R 3  and R 9  or R 14  are bound; R 4  is taken among the group including hydrogen atom and oxo- group; or R 4  in common with R 13  mean additional bond between carbon atoms with that R 4  and R 13  are bound; R 5  is taken among the group including hydrogen atom and hydroxy-group; or R 5  in common with R 6  mean additional bond between carbon atoms with that R 5  and R 6  are bound; R 6  means hydrogen atom; or R 6  in common with R 5  mean additional bond between carbon atoms with that R 6  and R 5  or R 14  are bound; R 9  means hydrogen atom; or R 9  in common with R 3  or R 10  mean additional bond between carbon atoms with that R 9  and R 3  or R 10  are bound; R 10  means hydrogen atom; or R 10  in common with R 9  mean additional bond between carbon atoms with that R 10  and R 9  are bound; R 11  is taken among the group including hydroxy-, acyloxy-, oxo-group, =NOR 28  where R 28  means hydrogen atom, halogen atom; or R 11  in common with R 12  mean additional bond between carbon atoms with that R 11  and R 12  are bound; R 12  means hydrogen atom; or R 12  in common with R 11  mean additional bond between carbon atoms with that R 12  and R 11  are bound; R 13  means hydrogen atom; or R 13  in common with R 4  or R 14  mean additional bond between carbon atoms with that R 13  and R 4  or R 14  are bound; R 14  means hydrogen atom; or R 14  in common with R 3 ,R 6  or R 13  means additional bond between carbon atoms with that R 14  and R 3  or R 6  or R 13  are bound; R 15  means hydrogen atom; R 16  is taken among the group including hydrogen atom, hydroxy-group, oxo-group; or R 16  in common with R 17  mean additional bond between carbon atoms with that R 16  and R 17  are bound; R 17  means hydrogen atom or hydroxygroup; or R 17  in common with R 16  mean additional bond between carbon atoms with that R 17  and R 16  are bound; R 18  and R 19  mean hydrogen atom; R 25  is taken among the group including hydrogen atom and C 1 -C 4 -alkyl; A means carbon atom or nitrogen atom; when A means carbon atom then R 7  is taken among the group including hydrogen atom, hydroxy- group and fluorine atom; R 8  is taken among the group including hydrogen atom, C 1 -C 4 -alkyl, methylene and halogen atom; or R 7  in common with R 8  mean additional bond between carbon atoms with that R 7  and R 8  are bound; R 20  means C 1 -C 4 -alkyl; and R 21  is taken among the group including C 1 -C 4 -alkyl, C 1 -C 4 -hydroxyalkyl, C 1 -C 4 - halogenalkyl comprising up to three halogen atoms; when A means nitrogen atom then R 7  means unshared electron pair; R 8  is taken among the group including hydrogen atom and oxo-group; R 20  and R 21  mean C 1 -C 4 -alkyl under condition that compound of the general formula (I) has no any cumulated double bonds and with additional condition that compound is not one of the known cholestene compounds. Compounds (I) can be used for regulation of meiosis in germinal cell of mammal. EFFECT: valuable biological properties of steroids. 67 cl, 2 tbl, 40 ex