baber/WOPTO huggingface dataset:
Patent SG-11201907299X-A (SG)
Title: Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
Inventor: CHANG GREGORY
IPC: C07K19/00
Filed: 2018-02-08
Abstract: WO 18/ 148 445 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 16 August 2018 (16.08.2018) WIPO I PCT o °nolo DID IIH momommornom oimIE (10) International Publication Number WO 2018/148445 Al (51) International Patent Classification: A61K 35/17 (2015.01) C07K 16/28 (2006.01) A61K 38/17 (2006.01) CO7K 16/30 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) (21) International Application Number: PCT/US2018/017470 (22) International Filing Date: 08 February 2018 (08.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/456,535 08 February 2017 (08.02.2017) US (71) Applicant: ADIMAB, LLC [US/US]; 7 Lucent Drive, Lebanon, NH 03766 (US). (72) Inventors: CHANG, Gregory, P.; 143 Saunders Street, Medford, MA 02155 (US). CHEUNG, Ann, F.; 25 Morn- ingside Lane, Lincoln, MA 01773 (US). HANEY, William; 61 Lincoln Road, Wayland, MA 01778 (US). GRINBERG, Asya; 37 Follen Road, Lexington, MA 02421 (US). (74) Agent: ASHRAF, Shovon et al.; Goodwin Procter LLP, 100 Northern Avenue, Boston, MA 02210 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (54) Title: MULTI-SPECIFIC BINDING PROTEINS FOR ACTIVATION OF NATURAL KILLER CELLS AND THERAPEUTIC USES THEREOF TO TREAT CANCER FIG. 1 (57) : Multi-specific binding proteins that bind a tumor associated antigen, the NKG2D receptor, and CD 16 are described, as well as pharmaceu- tical compositions and therapeutic methods useful for the treatment of cancer.
Patent HU-197484-B (HU)
Inventor: GYIMESI JANOS
IPC: A01G25/00
Filed: 1986-01-03
Abstract: A találmány öntözó'berendezésre vonatkozik, amelynek be és kivezető csonk (ok) kai ellátott vezérlőszerkezete, valamint a kivezető csonk (ok) ra csatlakoztatott öntözővizet szállító csővezetéke(i) van(nak). A találmány lényege az, hogy az öntözőberendezés vezérlőszerkezetének (3) vezérlővíz-bevezetőcsonkja (4) van, amely a vizet szállító fővezetéket (1) megcsapoló vezérlővíz-vezetékkel (2) van a vizet szállító fővezetékhez (1) csatlakoztatva, valamint az öntözővíz áramlási irányával megegyező irányban bővülő keresztmetszetű öntözőnyílásokkal (13) ellátott vízszintesen elhelyezett, vagy azonos keresztmetszetű öntözőnyílásokkal (13) ellátott és az öntözővíz áramlási irányával megegyező irányban a vízszinteshez képest lejtéssel elhelyezett, az. öntözővíz betáplálásával ellentétes végén zárt öntözővezeték (ek) (12) a vezérlőszerkezet (3) öntözővíz-elvezetőcsonkja (i) n (7) keresztül van (nak) csatlakoztatva a vezérlőszerkezet (3) sokjáratú-csapjához (31).  29 2. ábra -1-
Patent HU-194252-B (HU)
Title: Process for producing new cepheme-carboxylic acid derivatives
Inventor: CURRAN WILLIAM V
IPC: C07D501/06
Filed: 1985-01-10
Abstract: Esters of cephalosporin derivatives which can be orally administered and used as prodrugs are disclosed.
Patent IS-2508-B (IS)
Inventor: PINI ALESSANDRO
IPC: A61K38/00
Filed: 1998-10-29
Abstract: According to the present invention there is provided a specific binding member which is specific for and binds directly to the ED-B oncofoetal domain of fibronectin (FN). The invention also provides materials and methods for the production of such binding members.
Patent AT-393639-B (AT)
IPC: B21D5/02
Filed: 1990-03-15
Granted: 1991-11-25
Abstract: Described is a sheet-metal bending device (1) with a sword-like upper punch (10) which can be moved up and down relative to a frame (2), at right angles to the plane of the sheet, and can optionally be rotated. Facing the upper punch (10) are two jaw-like lower punches (19, 20) which cen be rotated relative to the upper punch (10) about a common axis passing through the zone in which bending of the sheet (18) takes place, the rotary motion being provided by a rotation mechanism (24), and the upper punch (10), when in its working position against the surface of the sheet (18), acting during the bending operation as a stationary counterpunch about which the sheet (18) is bent by the lower punches (19, 20).
Patent AT-405822-B (AT)
Title: Apparatus for producing stacks
IPC: B65G57/02
Filed: 1998-05-12
Granted: 1999-11-25
Abstract: Apparatus for producing stacks 10 of essentially parallelepiped articles 2, having a conveyor 1 which feeds said articles individually. In order to allow mechanical stacking, it is provided that a shaft 2 is provided in the ejecting region of the conveyor 1, of which shaft two mutually parallel walls 8, 9 terminate at a distance, which corresponds to the height of the envisaged stack 10, above a base plate 7 which is adjoined by a stack-withdrawal means 13, and also provided is a pusher 11 which can be moved in the conveying direction of said stack-withdrawal means and has a pushing plate 12 and a carrying plate 15 which projects horizontally from the top border of said pushing plate and, with the pusher 12 advanced in relation to the stack-withdrawal means 13, terminates the shaft 5 at the bottom, and that provided in the plane of the carrying plate 15, in that region of the shaft 5 which is in the vicinity of the stack-withdrawal means 13, is a bearing means 22 which can be pivoted in and out of the clear cross section of said shaft 5. <IMAGE>
Patent DK-155663-B (DK)
Inventor: SCHROEDER EBERHARD
IPC: A61P43/00
Filed: 1982-01-27
Abstract: Compounds of the formula    <IMAGE>  (I)  wherein R1 is hydrogen, methanesulfonyl, or acetyl, R2 and R3 jointly mean oxo, oximino, or separately two hydrogen atoms, or R2 is hydrogen and R3 is hydroxy or amino, and when R3 is amino, the physiologically acceptable acid salts thereof possess valuable pharmacological properties.
Patent HU-187766-B (HU)
Inventor: BALOGH LASZLO
IPC: G01M15/00
Filed: 1981-02-11
Abstract: A találmány eljárás és berendezés mechanikai üzemű gépi berendezések, különösen élelmiszeripari feldolgozógép műszaki állapotának szétszerelés nélküli meghatározására, a gépálfapot időközönkénti regisztrálására. A találmány szerint úgy járunk el, hogy egyidejűleg automatikusan összehasonlítjuk a berendezésen mért paramétereket, így rezgési, hőmérsékleti, teljesítmény stb. jellemzőket, valamint a gyártott termék minőségi jellemzőit. A mért értékek egymáshoz képesti és a referencia jeltől való eltérése alapján, illetve a jelek változási sebességéből következtetünk a gépállapotra, illetve a javítási időpontra. A mért jellemzők zavaró egymásra hatását automatikusan kompenzáljuk. A találmány szerint; berendezés rendelkezik erősítővel, AD konverterrel, tároló, kiértékelő, kézi adatbevivő egységgel a szükséges érzékelőkkel, ezek közül hőfokérzékelővel, teljesitményérzékelővel, ezek rendre a (6) erősítő bemenetelre csatlakoznak, (10) kiértékelő egysége pedig tartalmaz (14) inverter, (15) kompenzátor, (16) különbségképző (17) differenciáló, (18) vezérlő és (19) elemző egységeket.  -1-
Patent HU-187049-B (HU)
Title: Method for recovering oil from underground sites
Inventor: BALZER DIETER
IPC: E21B43/22
Filed: 1983-03-04
Abstract: 1. A process for recovering oil from a subterranean deposit of medium or high salinity by forcing into an injection bore a 0.1 to 30% solution or dispersion in formation water or floodwater of a carboxy-methylated oxyethylate surfactant of the formula R-(OCH2 CH2 )n -OCH2 -COOM where R is a linear or branched aliphatic radical of 6 to 20 carbon atoms or a monoalkylaromatic or dialkylaromatic radical of 3 to 16 carbon atoms in the alkyl group(s), M is an alkali metal or alkaline earth metal or ammonium ion and which has a degree of carboxymethylation is from 10% to 90%, the surfactant being chosen so that the phase inversion temperature of the system of crude oil/formation water or floodwater/surfactant/optional additive(s) is the temperature of the deposit or up to 10 degrees C above that temperature, characterised in that n is from 1 to 3.
Patent LT-3407-B (LT)
Title: System of independent processing filter-tipped cigarette
Inventor: MENTZEL EDGAR
IPC: A24C5/47
Filed: 1993-08-02
Abstract: The invention relates to a system for producing home-made filter cigarettes, consisting of a) a cigarette paper wrapper (10) with filter tip (12, 14), b) a tobacco cartridge (2) which is severed by a cutting step from a tobacco rod and prefabricated in the factory and consists of a tobacco portion (4) which is open at the end face, corresponds to the tobacco filling of a finished cigarette and can be introduced into a cigarette paper wrapper and whose outer surface is formed by a wrapper (6) which consists of completely smokable material and has an air permeability such that it cannot be smoked as such but is consumable by smoking after it has been introduced into the cigarette paper wrapper (10), characterised in that the tobacco cartridge has different diameters (16, 16') in different zones and that these consist of different tobacco mixtures. <IMAGE>
Patent ZA-92892-B (ZA)
Title: A process for the preparation of homoserine lactones
Inventor: HOFFMANN MICHAEL G
IPC: C07D263/18
Filed: 1992-02-07
Abstract: alpha -Amino- gamma -butyrolactones (homoserine lactones) are a central structural element in many biologically active compounds. The known syntheses for the preparation of optically active homoserine lactones from D- or L-methionine and D- or L-aspartic acid derivatives have disadvantages. According to the invention, homoserine lactones I and their salts can be prepared enantioselectively if aldehydes II are catalytically hydrogenated 
<IMAGE>
 where R in the formulae denotes hydrogen, alkyl, alkenyl, alkynyl, it being possible for the above three radicals to have hetero atoms in the chain, alkylcarbonyl, alkoxycarbonyl, alkylsulphonyl, benzyl, benzyloxycarbonyl, aryloxycarbonyl or arylsulphonyl, it being possible for the four last-mentioned radicals to be optionally substituted in the aryl moiety.
Patent ZA-93317-B (ZA)
Title: Bleaching of chemical pulp
Inventor: LINDSTROEM LARS-AAKE
IPC: D21C9/16
Filed: 1993-01-18
Abstract: A method of bleaching sulphate pulp without using chlorine-containing bleaching agents. The sulphate pulp is oxygen delignified and can possibly also be ozone delignified to a kappa number below 9.5. Thereafter a pretreatment with complexing agent is carried out for 1-60 minutes, at which the pulp consistency is 1-15 %, the temperature 70-110  DEG C and pH 5-7. The pulp thus pretreated is washed and dewatered to a consistency of 18-40 %. Thereafter peroxide bleaching in alkaline environment takes place in the presence of silicate or an organic complexing agent of the type phosphonic or carboxylic acid.
Patent ZA-93810-B (ZA)
Title: Derivatives of pyridine, their preparation process, the new intermediates obtained, their application as medicaments and the pharmaceutical compositions containing them
Inventor: FORTIN MICHEL
IPC: A61K31/4427
Filed: 1993-02-05
Abstract: Products of formula (I), wherein R1?, R2?, R3? and R4? are a hydrogen atom, a halogen atom, or a hydroxyl, mercapto, cyano, nitro, sulpho, formyl, benzoyl, acyl, carboxy, cycloalkyl or acyloxy radical; an alkyl, alkenyl, alkynyl, alkyloxy or alkylthio radical; an aryl, arylalkyl, arylalkenyl, aryloxy or arylthio radical; a radical (a), (b) or (c); a radical -(CH2?)m1?-S(O)m2?-Z'-R'14? wherein m1 is an integer from 0 to 4, m2 is an integer from 0 to 2, R5? is a divalent alkylene radical, and Y is a radical -Y1?-B-Y2?. The products have interesting pharmacological properties which justify their use as drugs.
Patent AT-391553-B (AT)
Title: Transport and storage device for thermosensitive products
IPC: F25B21/02
Filed: 1988-05-13
Granted: 1990-10-25
Abstract: The invention relates to a transport and storage device for thermosensitive products, in which one or more Peltier elements are provided for controlling the temperature of the storage space, tubular thermal conduction elements being provided on that plate of the Peltier element or elements facing the storage space, and that plate of the Peltier element or elements facing the casing being formed by finned heat exchange elements, the tubular heat exchange elements which, directly adjoining one another, form the inside of the storage space being hollow shaped articles which are made of a material having high thermal conductivity and have a prismatic, in particular quadrilateral cross section. This being the case, the individual tubular thermal conduction elements directly adjoining one another are designed as a one- piece thermal conduction element 1 made of a material with high thermal conductivity. <IMAGE>
Patent AT-395935-B (AT)
Title: Ski boot
IPC: A43B5/04
Filed: 1987-06-24
Granted: 1993-04-26
Abstract: Ski boot with a shell 1 and a shaft 2 which consists of a panel 4 forming the front part of the shaft and a cover 3 forming the rear part of the shaft. The cover is pivotable backwards in relation to the shell about an axis running transversely to the direction of travel, so that entry to the ski boot can take place from the rear when it is put on. Inside the shell 1, between the latter and an inner boot 15, a pressure distribution plate 13 is arranged, which extends at least over the instep region and can be pressed against the inner boot 15 by means of a cable pull 17, 18 operated by a tensioning device. The shell 1 is open as far as the tip region and the lateral flaps 10, 11 thus formed can be pressed against the inner boot 15 by two cable pulls 17, 18 or 17', 18' via the pressure distribution plate 16. <IMAGE>
Patent AT-396183-B (AT)
IPC: G02B6/40
Filed: 1988-06-28
Granted: 1993-06-25
Abstract: A holder for holding the end section, facing a light source, of a bundle 1 of optical conductors made from plastic comprises an elongated body 2 which is provided with a continuous, stepped bore 3, 4, and from whose end facing the light source the optical conductors lead to light ports (outlets) forming display devices or the like. The body 2 consists of a material which is a good conductor of heat, in particular metal, and the space between the wall of the bore section 4 of larger diameter and the bundle 1 of optical conductors is filled up with a potting (sealing) compound 7, 8. In order to achieve good thermal dissipation, the bore section 3 facing the light source and having the smaller diameter has a diameter corresponding to the outside diameter of the bundle 1. Furthermore, in a subregion of the bore section 4, facing the bore section 3 of smaller diameter, with the larger diameter, a softer potting compound 7 is filled in than in the adjacent region of this section 4. <IMAGE>
Patent AT-402741-B (AT)
IPC: D04H1/425
Filed: 1995-10-13
Granted: 1997-08-25
Abstract: PCT No. PCT/AT96/00188 Sec. 371 Date Aug. 22, 1997 Sec. 102(e) Date Aug. 22, 1997 PCT Filed Oct. 8, 1996 PCT Pub. No. WO97/14829 PCT Pub. Date Apr. 24, 1997A process for the production of cellulose fibers, comprising the following steps: (A) dissolving a cellulose-containing material in an aqueous, tertiary amine-oxide to obtain a spinnable cellulose solution; (B) spinning said cellulose solution and passing it through an aqueous precipitation bath, whereby water-containing, swollen filaments are obtained; (C) squeezing said water-containing, swollen filaments at various points, so that at least two squeezing points per millimeter of filament length on average are achieved and (D) drying said squeezed filaments to cellulose fibers, wherein squeezing is carried out using a pressure big enough so that said squeezing points produced on the filament are preserved also on the dried fibre and may be seen as color variations when observed under linearly polarized light.
Patent AT-400016-B (AT)
Title: Process for producing shaped articles from a lightweight- concrete structural part
IPC: B28B19/00
Filed: 1992-12-01
Granted: 1995-09-25
Abstract: Process for producing shaped articles from a lightweight- concrete structural part, with a cladding formed from panels, the panels being provided with anchorage parts and being positioned in a mould which is filled with lightweight concrete, in particular styrene concrete with a density of up to 0.6 kg/l. In order to achieve a good connection between the panel a and the moulding, provision is made to use, for producing the cladding, panels a which are provided with integrally formed extensions which project from the rear side of the panels a and are of cross-sectionally barb-like form in their free end regions w. <IMAGE>
Patent DK-160644-B (DK)
Inventor: WOERNER THEO
IPC: F23D14/12
Filed: 1985-12-04
Abstract: 1. An outer radiant heating tube for an industrial burner having a ceramic flame tube (3) consisting at least partially of individual ceramic tube portions (7, 7a) which are interconnected positively at their ends and with which externally disposed rib-like or cam-like spacing members (14, 16) are associated for radial bearing against an outer tube (1) enclosing the flame tube, each of the tube portions being formed at one end as a socket (8) and having at the other end a cylindrical zone (9) fitting into such socket, characterized in that adjoining tube portions (7, 7a) are inserted into one another with clearance at the socket connecting places, and fitted with clearance on to the outside of the flame tube (3) in the zone of each of the socket connecting places is a ceramic covering ring (11) which is positively fixed to the flame tube (3) in the axial direction, extends in the axial direction over a portion of the cylindrical zone (9) of each tube portion (7, 7a) and is at least partially covered by the associated socket (8).
Patent FI-61968-B (FI)
Inventor: BUCHANAN DONALD GEORGE
IPC: H03K21/18
Filed: 1974-05-02
Granted: 1982-06-30
Abstract: 1473828 Lamp failure alarms DRESSER EUROPE SA 3 May 1974 [3 May 1973] 21139/73 Heading G4N In a seven-segment display device of the type having a common anode 2 and a cathode 3 for each segment with a cathode driver 4 connected to each cathode, or vice versa, a respective circuit connection 6 including a series diode 7 is connected to each cathode (or anode) and a detector 8 is connected to each connection so as to draw current through the respective diode from the respective cathode driver (or anode driver) in the event of a segment failure, the output from the detector being arranged to give a warning indication. This indication may be given by a visible and/or audible warning device 10 and/or by causing all the cathodes to be energized. In the arrangement described with reference to Fig. 2 (not shown), thirteen display devices are provided respective cathodes being connected in common to the cathode drivers and to the circuit connections 6. This arrangement is activated in a time-division multiplex manner. The display device arrangement may be provided on the dispensing nozzle of a fuel pump as described with reference to Figs. 3 and 4 (not shown).
Patent FI-70334-B (FI)
Inventor: BLASCHKE FELIX
IPC: G06G7/22
Filed: 1980-04-18
Granted: 1986-02-28
Abstract: For forming   <IMAGE>   in a pulse width multiplier, two input voltages bi are summed at the input of an inverter and are added, after each passes through a separate switch and proportional stage, at the input of a smoothing stage, to the inverter output signal. The switches are actuated by switching pulses which are width-modulated in accordance with the factors ci. The calculated sum is present at the output of the smoothing stage. Great accuracy in field-oriented control of rotating-field machines is possible when vector analyzers and vector rotators designed in this manner are used.
Patent FI-69152-B (FI)
Inventor: BERNER KURT
IPC: B05C1/08
Filed: 1982-10-21
Granted: 1985-08-30
Abstract: Three paperboard webs are glued to one another with as little expenditure of energy as possible. After leaving the gluing apparatus, the finished sheets cut to size are ready for shipment. The middle paperboard web is passed through between two steel rolls which apply glue homogeneously to both sides of the web. High linear pressure is produced in the region of the generatrices of the steel rolls respectively touching the web. Such pressure is necessary in order that a highly viscous polymeric synthetic or natural adhesive, preferably with a solids content of more than 50%, can be used. No special drying facilities are needed, and the water-soluble glue allows recycling without problems.
Patent FI-80483-B (FI)
Inventor: BERGER JOHANN
IPC: D04B27/06
Filed: 1985-05-23
Granted: 1990-02-28
Abstract: A clamping device for attaching crochet needles to the needle bar of a galloon crochet machine or Raschel loom. The clamping device consists of two body pieces, a lower piece and a clamping lid, which are fastened together by means of clamps. In one embodiment the body piece holds the needle shafts, a spacer inserted into each interval between needles, and a support piece between the shafts of a needle and a receptacle in the lower piece. This results in the formation of needle beds. In the other embodiment very shallow grooves are milled opposite one another in both body pieces. These are only a fraction of half the height of the needle shafts, leaving the major part of the needle shaft's height free after clamping.
Patent FI-82245-B (FI)
Inventor: BIERE HELMUT
IPC: C07D471/04
Filed: 1986-12-19
Granted: 1990-10-31
Abstract: Compounds of formula I   <IMAGE>   wherein n is 0 or 1, R1 is hydrogen or lower alkyl, R2 and R3 each independently is hydrogen, optionally substituted lower alkyl, acyl or aryl, or together with the nitrogen atom form a 5-6-member heterocycle, R4 is hydrogen, lower alkyl or lower alkoxyalkyl and X is COOR6, CO-NR7R8, or an oxadiazolyl radical of the formula   <IMAGE>  wherein R5 is H, lower alkyl or cycloalkyl, R6 is H or lower alkyl, R7 and R8 each independently is hydrogen, optionally substituted lower alkyl, acyl or aryl, or R7 and R8 together with the nitrogen atom can form a 5-6-member heterocycle, are valuable drugs, e.g., have psychotropic activity.
Patent FI-85656-B (FI)
Inventor: DENNY PATRICK JOHN
IPC: B01D53/02
Filed: 1987-04-24
Granted: 1992-02-14
Abstract: Agglomerates containing oxides, hydroxides, carbonates and/or basic carbonates of copper, and zinc and/or another element such as aluminium or silicon, are useful for removal of sulphur compounds from fluids, especially under non-reducing conditions. The agglomerates have surface area above 80 m<2>.g<-><1> and a calcined density below 1.5 g.cm<-><3>. After ignition, the cupric oxide plus zinc oxide (if any) content of the agglomerates is at least 70% w/w. The proportion of the cooper compound is such that the copper atoms constitute 30-97% of the total of the copper, zinc, and said other element atoms in the agglomerates.