baber/WOPTO huggingface dataset:
Patent CA-2376675-A1 (CA)
Title: Antagonists of bmp and tgf.beta. signalling pathways
Inventor: THOMSEN GERALD H
IPC: A61P25/00
Filed: 2000-06-12
Abstract: This invention provides unique members of the Hect family of ubiquitin ligases that specifically target BMP and TGF.beta./activin pathway-specific Smads. The novel ligases have been named Smurf1 and Smurf2. They directly interact with Smads1 and 5 and Smad7, respectively, and regulate the ubiquitination, turnover and activity of Smads and other proteins of these pathways. Smurf1 interferes with biological responses to BMP, but not activin signalling. In amphibian embryos Smurf1 inhibits endogenous BMP signals, resulting in altered pattern formation and cell fate specification in the mesoderm and ectoderm.  The present invention provides a unique regulatory link between the ubiquitination pathway and the control of cell fate determination by the TGF.beta. superfamily during embryonic development. Thus, Smurf1 is a negative regulator of Smad1 signal transduction, by targeting Smad1, Smurf1 blocks BMP  signalling. In mammalian cells, Smurf2 suppresses TGF.beta. signalling, and in Xenopus, blocks formation of dorsal mesoderm and causes anterior truncation of the embryos. Smurf2 forms a stable complex with Smad7, which induces degradation and downregulation of TGF.beta./activin signalling.
Patent CA-2376726-A1 (CA)
Title: Laser-resistant medical retrieval device
Inventor: CHU MICHAEL S H
IPC: A61F2/01
Filed: 2000-09-14
Abstract: A medical device used for retrieving material from within a body includes an engaging assembly in which at least a portion of the engaging assembly is resistant to laser energy-induced damage.
Patent CA-2377591-A1 (CA)
Inventor: WOODLEY MARK
IPC: F16F7/12
Filed: 2000-06-15
Abstract: L'invention concerne un dispositif (10) d'absorption d'énergie comprenant une partie (11) corps central et au moins trois pieds (33, 34) s'étendant vers l'extérieur depuis cette partie (11) corps central. Chacun des pieds (33, 34) comporte une première et une seconde extrémité, les premières extrémités des pieds étant liées les unes aux autres ainsi qu'à la partie (11) corps de manière à définir des dispositifs de support adaptés pour supporter une longueur d'un câble de sécurité allongé. La seconde extrémité de chacun des pieds (33, 34) est reliée à un élément pied (41). Chaque élément pied (41) peut subir une déformation plastique permanente en réaction au chargement par à-coups brusques transmis par le câble de sécurité allongé. La déformation plastique permanente est efficace pour absorber au moins une partie de l'énergie du chargement par à-coups brusques.
Patent CA-2379977-A1 (CA)
Inventor: HORNBERGER WILFRIED
IPC: A61P9/08
Filed: 2000-08-01
Abstract: L'invention concerne de nouveaux composés qui se lient aux récepteurs intégrines, ainsi que leur production et leur utilisation comme médicaments.
Patent CA-2380914-A1 (CA)
Title: Gas turbine combustor
Inventor: TOMIMOTO SOUICHIROU
IPC: F23R3/00
Filed: 2002-04-05
Abstract: An internal cylinder which has the opening section from which combustion gas is blown out is inserted into the tail cylinder which becomes a flow path of the combustion gas, and is engaged with the tail cylinder, while securing a clearance between the edge of the opening section and the internal wall surface of the tail cylinder. Air compressed with a compressor is jetted from the clearance along the internal wall surface of the tail cylinder, and a film of cooling air is formed on the internal wall surface of the tail cylinder.
Patent CA-2381219-A1 (CA)
Title: Monomeric protein of the tgf-beta family
Inventor: POHL JENS
IPC: A61K38/18
Filed: 2000-08-04
Abstract: The present invention is concerned with proteins selected from the members of the TGF-.beta. superfamily, which are monomeric due to substitution or deletion of a cysteine which is responsible for dimer formation. The invention is also concerned with nucleic acids, encoding such monomeric proteins, vectors or host cells containing the nucleic acids as well as with pharmaceutical compositions comprising the proteins or nucleic acids encoding the proteins.  The pharmaceutical compositions can be applied advantageously for all indications for which the respective dimeric proteins are useful.
Patent CA-2381275-A1 (CA)
Title: Assay for detecting damage to the central nervous system
Inventor: RIBLET LESLIE A
IPC: G01N33/68
Filed: 2000-08-25
Abstract: A method is disclosed for the rapid diagnosis of disorders characterized by an ischemic event, such as stroke, transient ischemic attack, head trauma, myocardial infarction, or other insults resulting in interrupted cranial blo od flow. The method involves detection of the presence of the gamma isoform of protein kinase C (PKCg) in peripheral blood, which signals damage to central  nervous system tissue and at least transient breakdown of the blood brain barrier. The assay may be performed, e.g., by emergency medical personnel, i n a time frame that allows treatment of the patient before permanent damage to  the central nervous system occurs.
Patent CA-2384036-A1 (CA)
Title: Seven-day clock
Inventor: GREENWOOD ERIC
IPC: G04B47/00
Filed: 2002-04-30
Abstract: A seven day clock includes an open-face and a single hand rotatably mounted to, and generally centrally disposed on, the face. A motor driver rotates the hand at a uniform rate of rotation, about an axis of rotation, in a plane parallel to the face.  The hand rotates in complete 360 degree revolutions about the face once every seven complete days.  The face is demarked into seven contiguous equal sectors each bounded by two radii extending radially outwardly from the axis of rotation and labelled consecutively with the consecutive days of a week. The clock is adapted for a user to apply removable writing so that the writing overlays the face, and so that the removable writing is within the sectors.
Patent CA-2384851-A1 (CA)
Title: Planning and administrating a manufacturing plant
Inventor: CASSERLY JAMES
IPC: G06Q10/00
Filed: 2000-10-18
Abstract: A method for planning and administrating the use of resources in a manufacturing process comprising a plurality of activities. The method comprises the steps of: 1) representing manufacturing activities as operations; 2) classifying manufacturing activities as either planned or active; 3) receiving material- or activity-related information; 4) creating an operation list (O) comprising operations, based on the material- or activity - related information; 5) representing active manufacturing activities as operation groups; 6) creating the operation groups by grouping operations in  the operation list (O) when activities are to be changed from planned to active state; 7) representing tangible or intangible properties which are modified by manufacturing activities as resources, wherein the modifying comprises use, creation, change and/or deletion of a resource by the corresponding activity; and 8) quantifying the modifying by associating resource data with operations.
Patent CA-2386570-A1 (CA)
Title: Readily customizable blind set
Inventor: LEE HAN-SEN
IPC: E06B9/28
Filed: 2002-05-15
Abstract: The structures and process of both forming and trimming the blind set include the provision of a channel extension or channel plug utilized in a blind set which has the louver manipulation components significantly inward to permit a reasonable amount of outboard removal while maintaining the balance and regular appearance of the blind set.  The channel plug acts to stabilize the "U" shaped upper channel by having an insertion portion which not only fills a structurally significant extent of the channel, but fully upwardly engages a pair of oppositely oriented curved inwardly and downwardly lips. An extension portion of the channel plug has a pair of upper rails which match and blend with the terminus of the pair of oppositely oriented curved inwardly and downwardly lips to provide both stability, visual continuity, and continuous upper, frontal, rear, and bottom support as will be had from the particular mounting method employed. The plug is typically made from a material as soft as the material from which the louvers or slats are made, such as wood, plastic, polyethylene, polyurethane, nylon, fiber glass, polypropylene, or the like.
Patent CA-2388503-A1 (CA)
Inventor: MAKRIYANNIS ALEXANDROS
IPC: A61P25/28
Filed: 2000-10-18
Abstract: Novel polycyclic cannabinoid analogs are presented which have preferentially high affinities for the cannabinoid CB2 receptor sites. The improved receptor affinity makes these analogs therapeutically useful as medications in individuals and animals for treatment of pain, glaucoma, epilepsy, nausea associated with chemotherapy.
Patent CA-2389612-A1 (CA)
Title: Improved welding socket
Inventor: PETRY DIRK
IPC: H01R13/24
Filed: 2000-09-14
Abstract: An electrofusion coupling (93) for joining together two or more sections of pipe, said coupling comprising: (i) a substantially cylindrical coupling body having an outer surface and an inner surface, the inner surface being sized and shaped to form a clearance fit with the outer surface of the pipe regions to be joined; (ii) at least one electrical heating (94) element set on or in the inner surface of the coupling body; (iii) terminal means adapted to connect the electrical heating means to an electrical supply; characterised in that the terminal means does not project beyond the outer cylindrical surface of the coupling body once the welding process is complete.
Patent CA-2391214-A1 (CA)
Title: Venous return cannula with enhanced drainage
Inventor: DAVIS SCOTT H
IPC: A61M1/36
Filed: 2000-11-07
Abstract: An improved venous drainage cannula having enhanced drainage for minimally invasive surgeries involving vacuum-assisted venous drainage. The cannula includes more than two discrete segments in which suction holes are provided. There may be a distal segment with suction holes and two segments spaced proximally therefrom with suction holes. The tubular cannula body terminates in a tapered tip and the distal suction segment extends proximally therefrom.  Between a first proximal suction segment and a distal suction segment, the cannula is reinforced. Likewise, the cannula is reinforced between the first proximal suction segment and the next suction segment. The reinforcement may be a helical wire molded into the wall of the cannula. The proximal suction segments are designed to reside within the right atrium during venous drainage. If one of the atrial suction segments becomes occluded by contact with the atrial wall, the other atrial suction segment maintains adequate flow from the right atrium.
Patent CA-2391552-A1 (CA)
Inventor: HOUWELING PAUL
IPC: A01G9/14
Filed: 2002-06-25
Abstract: Apparatus for handling and controlling the nurturing of plants comprises a greenhouse for providing a first environmental zone for nurturing plants, a plant warehouse for providing a second environmental zone for nurturing plants, transport rails extending from within the first environmental zone to within the second environmental zone, and a plurality of ebb and flood trays. The first environmental zone is located in the greenhouse in a region positioned to receive substantial amounts of sunlight. The second environmental zone is located in the warehouse in a region substantially sheltered from sunlight. The ebb and flood trays each include a valve for controlling fluid flow into and out from a flood region within the tray. The valve includes means for receiving a fluid flow frog an external source of fluid through a top end of the valve and, in response to the flow, for diverting the flow into the flood region of the tray. Further the valve includes means responsive to the absence of the flow for permitting fluid from the flood region to drain through a bottom end of the valve. A method of handling and controlling the nurturing of plants in an ebb and flood tray includes the steps of maintaining first and second environmental zones for nurturing plants; maintaining transport rails extending from within the first environmental zone to within the second environmental zone, adapting the tray for riding movement on the rails, positioning the tray on the rails for such movement, and carrying the plants in the tray.  The first zone is located in a structure in a region positioned to receive substantial amounts of sunlight. The second zone is located in a structure in a region substantially sheltered from sunlight. At a first time, and if a first prescribed condition is satisfied, the tray with the plants is moved along the rails from within the first environmental zone to within the second environmental zone. At a subsequent time, and if a second prescribed condition is satisfied, the tray with the plants is moved along the rails from within the second environmental zone to within the first environmental zone.
Patent CA-2391703-A1 (CA)
Inventor: NIEN MING
IPC: E06B9/264
Filed: 2002-06-26
Abstract: A combination curtain and blind arrangement is constructed to include a Venetian blind and a plurality of curtains. The Venetian blind has a headrail, a bottom rail, a plurality of slats, and a lift cord and ilt cord unit adapted for joining the headrail, the bottom rail and the slats and keeping the slats arranged between said headrail and said bottom rail The curtains are respectively formed of a piece of fabric defining a cover face and at least one suspension face extended from the cover face. The cover face of each curtain   an insertion    unit for   passing of the lift has            hole            the cord and tilt cord unit for enabling the cover face of each curtain to be covered on one slat to hold the at least one suspension face of the respective curtain suspended from the corresponding slat.
Patent CA-2393286-A1 (CA)
Title: Four color modular printhead system
Inventor: SILVERBROOK KIA
IPC: B41J2/235
Filed: 2000-12-07
Abstract: A printhead system includes a plurality of printhead assemblies (10) aligned in end-to-end relationship. Each print-head assembly (10) includes a plurality of printhead modules (12), the printhead modules (12) being arranged in end-to-end rela-tionship and being angled with respect to a longitudinal axis of the assembly (10) such that printhead chips (18) of adjacent modules (12) overlap in a direction transversely to a direction of movement of print media past the assemblies (10).
Patent CA-2396760-A1 (CA)
Inventor: WERNETH RANDELL L
IPC: A61M25/00
Filed: 2001-01-16
Abstract: The invention provides a device for heating or cooling a surrounding fluid in a feeding vessel and a method of manufacturing the same. The device includes a catheter assembly (400) capable of insertion to a selected blood vessel in the vascular system of a patient. The assembly includes an elongated catheter body, a heat transfer element (404) located at the distal end of the catheter and including an interior (410), an elongated supply lumen (442) adapted to deliver a working fluid to the interior of the heat transfer element and having a hydraulic diameter (D2), an elongated return lumen (436) for the working fluid having a hydraulic diameter (D3), and wherein the ratio of the hydraulic diameter of the return to the supply lumen is equal to 0.75.
Patent CA-2398294-A1 (CA)
Title: System, method, computer program product for communicating data for objects that are transported from first location to second location
Inventor: HALLER STEPHAN
IPC: G06K17/00
Filed: 2001-10-19
Abstract: Computer-assisted procedure (501/502) to communicate data in a transportation system (90) that physically transports objects (800) from first to second locations (10, 20). The objects (800) have write/read memory tags (300). Prior to communicating, data is separated into meta-data M and content-data C. Communicated are: C on the tags (300), M through a computer network, and type-data T (representing M) on the tags. System computers (901, 902, 900) perform complementary methods for forwarding (501) and retrieving (502). To forward (501) data from the first location (10), a first computer (901) queries (510) an exchange computer (901) with M for T according to a predefined T-to-M table, writes T to the tags (300), and writes C to the tags (300). To retrieve (502) data at the second location (20) where the objects arrive, a second computer (902) reads T from the tags (300), queries (550) the exchange computer (900) with T for M according to the same table, and reads (560) C from the tags (300).
Patent CA-2399047-A1 (CA)
Inventor: RUSSELL JOHN C
IPC: C07K16/18
Filed: 2001-02-28
Abstract: L'invention porte sur un ensemble de séquences d'ARN contiguës et se recouvrant partiellement et sur les polypeptides codés par elles. Lesdites séquences, dites BS106, transcrites à partir de tissus mammaires, peuvent servir à la détection, au diagnostic, à la stadification, au suivi, aux pronostics, à la prévention, et au traitement des maladies et pathologies du sein tels que le cancer, et à déterminer la prédisposition d'un individu à ces maladies et pathologies. L'invention porte également sur des anticorps se fixant spécifiquement aux polypeptide ou protéines codés par les BS106 et sur des agonistes ou inhibiteurs empêchant l'action des polypeptide BS106 spécifiques d'un tissu, ces molécules étant utiles pour le traitement des maladies, tumeurs, et métastases du sein.
Patent CA-2400178-A1 (CA)
Title: Nail lacquer pharmaceutical composition
Inventor: GYURIK ROBERT J
IPC: A61K31/4164
Filed: 2001-02-16
Abstract: A composition comprising a pharmaceutical compound, a membrane-permeation enhancer, and a polymeric film-forming agent, including, for example, a hydrocarbon-based liquid nail lacquer comprising a solution of an anti-funga l agent in a pharmaceutically-effective amount, a membrane-compatible permeati on enhancer in an amount effective to enhance penetration through a membrane or  nail of said anti-fungal agent, a polymeric film-forming agent in an amount effective to form an adherent polymeric film on a membrane or nail, and a solvent for forming said solution; and a method for forming on a membrane or  nail of the body an adherent film containing a pharmaceutical compound and permeation enhancer from a solution of the components in which there is used  a mixture of solvents, including a solvent which is highly volatile and a solvent of lower volatility.
Patent CA-2403324-A1 (CA)
Inventor: MAALEJ KHALED
IPC: H04L1/00
Filed: 2001-02-12
Abstract: L'invention concerne un circuit (35) de récupération de rythme dans un démodulateur MAQ qui fait appel à un filtre d'interpolation à adaptation continue du débit de symboles. Le procédé d'interpolation utilisé est défini comme une fonction du temps par intervalle d'interpolation plutôt que la fonction du temps par intervalle d'échantillonnage utilisée de manière courante dans les procédés existants. Ce procédé permet ainsi au filtrage d'interpolation d'être totalement indépendant du débit de symboles en termes de complexité et de performance, et assure une réjection améliorée des canaux adjacents, étant donné que l'interpolateur effectue la réjection de la majeure partie du signal en dehors de la largeur de bande du canal reçu.
Patent CA-2403441-A1 (CA)
Title: Antimicrobial bioabsorbable materials
Inventor: DJOKIC STOJAN
IPC: A61K33/24
Filed: 2001-04-17
Abstract: The invention provides bioabsorbable materials with antimicrobial coatings or powders which provide an effective and sustainable antimicrobial effect. Specifically, this invention provides bioabsorbable materials comprising a bioabsorbable substrate associated with one or more antimicrobial metals being in a crystalline form characterized by sufficient atomic disorder, such that the bioabsorbable material in contact with an alcohol or water based electrolyte, releases atoms, ion, molecules, or clusters of at least one antimicrobial metal at a concentration sufficient to provide an antimicrobial effect. The one or more antimicrobial metals do not interfere with the bioabsorption of the bioabsorbable material, and do not leave behind particulates lager than 2 µm, as measured 24 hours after the bioabsorbable material has disappeared. Most preferably, the particulate sizing from the coating or powder is sub-micron, that is less than about 1 µm, as measured 24 hours after the bioabsorbable material has disappeared. Particulates are thus sized to avoid deleterious immune responses or toxic effects. Such antimicrobial metals are in the form of a continuous or discontinuous coating, a powder, or a coating on a bioabsorbable powder.
Patent CA-2404275-A1 (CA)
Title: Cosmetic use of hop and ornithine
Inventor: VAN DE WIEL ADRIAAN EMANUEL HE
IPC: A61P17/02
Filed: 2001-03-22
Abstract: A composition for use as cosmetic agent for enhancing breast growth and strengthening of the breast issue comprises at least hop and ornithine. Fennel or a fennel derivative such as fennel leaf or fennel seed is preferably further added thereto. The composition can also be applied as medication for suppressing and preventing benign cysts. The composition can be manufactured in convenient tablet form and be made up wholly of natural constituents.  Ingestion of the composition for a period of a few months will in most cases provide the first result.
Patent CA-2405904-A1 (CA)
Title: Polyurethane products produced from aluminum phosphonate catalyzed polyetherols
Inventor: DEXHEIMER EDWARD M
IPC: C09J11/00
Filed: 2002-09-25
Abstract: A method for the production of polyurethane products using very low unsaturation polyether polyols prepared in the presence of aluminum phosphonate catalysts is disclosed.  Reaction products of the process include various polyurethane products including foams, coatings, adhesives, sealants and elastomers. The aluminum phosphonate catalyst preferably has a general structure of RPO-(OAlR'R")2 , wherein O represents oxygen, P  represents pentavalent phosphorous, Al represents aluminum, R comprises a hydrogen, an alkyl group, or an aryl group, and R' and R" independently comprise a halide, an alkyl group, an alkoxy group, an aryl group, or an aryloxy group.
Patent CA-2408235-A1 (CA)
Title: Microscale mass spectrometric chemical-gas sensor
Inventor: GENTRY W RONALD
IPC: H01J49/28
Filed: 2001-05-07
Abstract: A mass sensor (10) includes a magnet assembly (12) and a mass analyzer (14).  The mass analyzer includes a ceramic housing formed from two end plates and a center portion. The mass analyzer further includes a thermionic electron emitter ionizer, a double focusing mass spectrometer having superimposed orthogonal magnetic and electric fields, and a microchannel plate ion detect or located in the housing cavity. The double focusing mass spectrometer include s an electric sector energy analyzer having a film resistor deposited on an inside surface of each end plate. The film resistors are substantially concentric and congruent and have a circular arc shape. Boundary electrodes are positioned adjacent each curved edge of each film resistor. The mass sensor includes a non-evaporable getter mounted inside the housing cavity an d external electrical contacts are arranged to form a multi-layer printed circuit card that is installable in a circuit card edge connector.
Patent CA-2408900-A1 (CA)
Title: Method of determining boundary interface changes in a natural resource deposit
Inventor: FELDMAN WALTER K
IPC: G06F19/00
Filed: 2001-04-13
Abstract: A method of determining changes in the boundary interface in a sub-surface oil reservoir between the to-be-recovered oil and a driveout fluid, such as steam, uses time-displaced gravity gradient measurements to provide an indication of the changes in the gravity gradient over time. The measured data are subject to a simulated annealing optimization to find the global minimum that best represents the observed values within the solution space. The optimization process includes establishing an appropriately constrained model of the oil reservoir and a quantized set of mathematically related parameters that define the model. Successive models are perturbed and evaluated from a figure of merit standpoint until a global minimum that best describes the measured time-lapse data is found.