baber/WOPTO huggingface dataset:
Patent UY-29853-A1 (UY)
Title: Derivados de diacilindazol como inhibidores de lipasas y fosfolipasas-
Inventor: MULLER DR GUNTHER
IPC: C07D413/00
Filed: 2006-10-11
Abstract: La presente invención se refiere a derivados de diacilindazol de fórmulas I o II que tienen los significados en la descripción, a sus sales farmacéuticamente útiles y a su uso como sustancias medicinales.
Patent UY-30617-A1 (UY)
Title: Derivados sustituidos del carbamato de 1-(9-{[(2r)-2-{4-hidroxi-3-[(metilsulfonil)amino]fenil}etil]amino}nonil)piperidin-4-ilo, sus sales y solvatos farmacéuticamente aceptables y aplicaciones
Inventor: JONES LYN HOWARD
IPC: A61P11/00
Filed: 2007-10-02
Abstract: La invencion se refiere a compuestos de formula (1) y a procesos para la preparacion de, intermedios usados en la preparacion de, composiciones que contienen y usos de, tales derivados. Los compuestos de acuerdo con la presente invencion son utiles en diversas enfermedades, trastornos y cuadros, en particular, enfermedades, trastornos y cuadros inflamatorios, alérgicos y respiratorios.
Patent UY-31280-A1 (UY)
Title: Oligonucleotidos inmunoestimuladores con un motivo de combinacion con actividad mejorada
Inventor: HANSON DOUGLAS CHARLES
IPC: A61K31/7115
Filed: 2008-08-11
Abstract: Se describen oligonucleotidos inmunoestimuladores que contienen un motivo inmonoestimulador CpG y un segundo motivo capaz de formar una estructura secundaria, incluyendo estructuras dobles y de orden superior in vitro e in vivo. Éstos incluyen ácidos nucleicos o sus sales farmacéuticamente aceptables, que tienen secuencias base que incluyen 5?? TCGTCGTTTTCGGCGCGCGCCGT 3??(SEC ID Ns:1), en donde cada C está sin metilar y 3?? del ácido nucleico. Los oligonucleotidos activan las células B y los linfocitos citolíticos naturales e inducen la expresion de interferon de tipo I e interferon-y. Los oligonucleotidos son utiles para tratar una diversidad de trastornos y afecciones que incluyen alergia, asma, infeccion y cáncer. Además de su uso como agentes individuales y como terapias de combinacion, los oligonucleotidos descritos son utiles como adyuvantes en vacunas.
Patent ES-155923-A1 (ES)
Title: Bogie articulado de 3 ejes para vehiculos, y especialmente para coches tranviarios
Filed: 1942-02-06
Abstract: La propiedad y explotación exclusivas de un bogie articulado de tres ejes para vehículos de carriles y especialmente para coches tranviarios en el cual ambos ejes extremos están articulados mediante bastidores giratorios sobre el eje central desplazable en sentido transversalcaracterizado por estar acopladas las cajas de eje (a)sin guías y mediante barras de conexión (o) en sí conocidasala carro articulado y apoyarse los muelles suspendidos de las cajas del eje (a)por ejemplo las ballestas (n)mediante armellas (1) o similares al bastidor articulado y servir sólo para recibir las fuerzas verticales y las fuerzas transversales horizontalesmientras que las fuerzas longitudinales son absorbidas exclusivamente por las barras de conexión (o) provistas de una guía de emergencia (u) de las cajas de eje (a).
Patent ES-180901-A1 (ES)
Title: MEJORAS INTRODUCIDAS EN LAS LLANTAS NEUMáTICAS
Filed: 1947-12-12
Abstract: Mejoras introducidas en las llantas neumáticas especialmente adaptadas para el uso sin cámara y que tienen un cuerpo abierto que termina en porciones de pestaña espaciadas, comprendiendo la llanta una pluralidad de nervios circunferencialmente continuos de material elástico a modo de caucho en la cara exterior de cada porción de pestaña, separados por lo menos en porciones de los mismos en el sentido radial de la llanta para formar hermeticidad con las bridas del borde bajo presión de inflación dentro de la llanta, por la presión resultante de los nervios contra las bridas de borde.
Patent ES-187648-A1 (ES)
Title: UN NUEVO PROCEDIMIENTO PARA LA OBTENCIoN DE CELULOSA
Filed: 1949-03-31
Abstract: Un nuevo procedimiento para la obtención de celulosa caracterizado porque la materia prima (madera pajas o hierbas cloradas o sus correspondientes semipastas cloradas) es tratada con amoníaco para solubilizar los incrustantes clorados recuperándose este amoníaco para la adición de cal.
Patent ES-193449-A1 (ES)
Title: Un aspirador de hilos para maquinas de hilar y analogas
Filed: 1950-06-16
Abstract: Un aparato consistente en un aspirador de hilos para máquinas de hilas y análogas esencialmente constituído por un grupo que comprende un ventilador un filtro un depósito para los materiales arrastrados y un difusor para la salida del aire formando las distintas partes enumeradas un conjunto o unidad establecido preferentemente en uno de los testeros de la propia máquina y de dicho conjunto arrancan dos tuberías principales o colectoras sí de la máquina es de dos caras que corren a lo largo de la misma y de cada una de las cuales arrancan unas derivaciones que van a parar directa o indirectamente a las boquillas aspiradoras de las que figuran una para cada uno de los husos de la propia máquina.
Patent ES-196611-A1 (ES)
Title: UN MECANISMO DE TRASLACIoN PARA POLIPASTOS ELÉCTRICOS
Filed: 1951-02-19
Abstract: Mecanismo de traslación para polipastos eléctricos caracterizado por comprender un mecanismo reductor constituido por una serie de engranes dispuestos de tal manera que el eje de salida queda a una altura de la base del reductor que permite a los piñones montados en el mismo actuar directamente sobre las coronas dentadas de las ruedas de traslación del polipasto permitiendo el paso de la viga de rodadura.
Patent ES-198590-A1 (ES)
Title: UN PROCEDIMIENTO DE PRODUCIR COMPUESTOS HETEROCiCLICOS
IPC: C07D319/06
Filed: 1951-07-02
Abstract: Un procedimiento para obtener un 1 3- dioxano compuesto correspondiente con la fórmula que comprende hacer reaccionar un acilamido diol compuesto correspondiente a la fórmula bajo condiciones anhidras en la presencia de un agente deshidratante con un compuesto de carbonilo correspondiente con la fórmula donde r representa un radical acílico de ácido carboxílico alifático inferior halogenado y R1 y R2 son iguales o distintos y represetan hidrógeno radicales alcoilo inferiores fenilo o fenalcoilo.
Patent ES-206625-A1 (ES)
Title: A process for making patterns for use in the production of articles of attire
IPC: D06M13/144
Filed: 1952-12-04
Abstract: At least one layer of a fabric of a cellulose derivative, e.g cellulose acetate, that is capable of stretching is applied to a part of a human body, the fabric being applied in tension to conform to the shape of the part. Before or after the fabric is thus applied it is treated with a volatile liquid that exerts a solvent action on the fabric. The liquid is allowed to evaporate whilst the fabric is on the body, whereby the fabric is rendered substantially incapable of stretching, and the fabric thus treated is removed in the form of a flexible mould. This mould may be a pattern for a dress or for making corsets, brassieres, gloves, surgical belts and footwear. The fabric may be knitted, woven or felted cellulose acetate fabric. The solvent for cellulose acetate may be any of these four liquid mixtures:- Percentages .Methanol.35.50.33.43.-.5.50 .Iso-propyl alcohol.35.43.-.-.5.43 p .Dimethyl ketone.28.55.-.25.50.88.55 .Formaldehyde.0.25.-.1.15.0.25 .Diacetone alcohol.0.15.-.0.33.0.15 .Benzaldehyde.0.10.2.07.-.0.10 .Ethanol.-.15.50.61.04.- .Methyl ethyl ketone.-.35.20.-.- .Benzyl alcohol.-.10.55.-.- .Acetaldehyde.-.3.20.-.- .Isoamyl alcohol.-.-.7.27.- .Methyl iso-butyl ketone.-.-.4.55.- .Acetophenone.-.-.0.12.- the balance being colour and perfumeALSO:At least one layer of a cellulose derivative fabric that is capable of stretching is applied to a part of a human body, the fabric being applied in tension to conform to the shape of the part. Before or after the fabric is thus applied it is treated with a volatile liquid that exerts a solvent action on the fabric. The liquid is allowed to evaporate whilst the fabric is on the human body part, whereby the fabric is rendered substantially incapable of stretching, and the fabric thus treated is removed from the part in the form of a flexible mould. This mould may be a pattern for a dress, and may be laid out and cut in such a way that a number of flat pieces are obtained which can be used as patterns for cutting parts of a dress or it may be a pattern for making corsets, brassieres, gloves, surgical belts and footwear. In making a dress pattern the fabric may be knitted, woven or felted cellulose acetate fabric which is made into a garment adapted to fit the person closely, e.g. from hips to neck, the garment being sewn up the back or provided with a sliding clasp fastener. The volatile liquid may be applied to the garment before the person puts it on, or after, in which latter case it may be sprayed on. The solvent for cellulose acetate may be any of these four liquids:- .Methanol.35.50.33.43.-.5.50 .Iso-propyl alcohol.35.43.-.-.5.43 .Dimethyl Ketone.28.55.-.25.50.88.55 .Formaldehyde.0.25.-.1.15.0.25 .Diacetone alcohol.0.15.-.0.33.0.15 .Benzaldehyde.0.10.2.07.-.0.10 .Ethanol.-.15.50.61.04.- .Methyl ethly ketone.-.35.20.-.- .Benzyl alcohol.-.10.55.-.- .Acetaldehyde.-.3.20.-.- .Isoamyl alcohol.-.-.7.27.- .Methyl iso-butyl ketone.-.-.4.55.- .Acetophenone.-.-.0.12.- the balance being colour and perfume
Patent ES-274803-A1 (ES)
Title: Anthraquinone dyestuffs
IPC: C09B1/503
Filed: 1962-02-20
Abstract: Water-insoluble anthraquinone dyes are made by treating with a chlorinating or brominating agent a dye or mixture of dyes of the formula <FORM:0962147/C4-C5/1> where on X is hydroxyl and the other X is amino, one A is alkyl which may be substituted by aryl or a heterocyclic residue and the other A is hydrogen, unsaturated alkyl or alkyl which may be substituted by aryl or a heterocyclic residue. The invention also comprises dyes of the formula <FORM:0962147/C4-C5/2> where the X radicals are as indicated above, one A is alkyl which may be substituted by aryl or a heterocyclic residue and the other A is hydrogen or alkyl which may be substituted by aryl, a heterocyclic residue or chlorine or bromine atoms, Hal is chlorine or bromine and Y is hydrogen, chlorine or bromine, the dyes containing per molecule 0.5 to 1.5 nuclear chlorine or bromine atoms. Chlorinating and brominating agents specified are chlorine and bromine and the halogenation may be effected in sulphuric acid in the presence of boric acid and iodine. The starting materials of formula I above are made by reacting leuco-1 : 5-dihydroxy - 4 : 8 - diamino- or -1 : 8 - dihydroxy - 4 : 5-diamino-anthraquinone or the corresponding sulphonic acids with an aldehyde. The dyes dye aromatic polyesters from aqueous dispersion in blue shades.
Patent ES-338930-A1 (ES)
Title: 2,3a-diazahydrindanone and 3h-pyrido-(1,2-c)pyrimidin-3-one derivatives
IPC: C07D211/34
Filed: 1967-04-05
Abstract: Novel compounds of general formula <FORM:1114397/C2/1> and salts thereof, wherein n is 0 or 1 and R is C1- 7 alkyl, optionally substituted by one or more OH,NH2, mono or dialkylamino, halo or heterocyclic substituents, or is aryl or aralkyl either of which groups may be substituted by one or more halo, NO2, NH2, OH, C1- 7 alkyl, C1- 7 alkoxy, C1- 7 aminoalkyl which may be N-substituted by one or two alkyl groups, CF3, C2- 7 alkoxycarbonyl, acyl or C2- 7 alkanoylamido substituents, are prepared by reacting an amide of general formula <FORM:1114397/C2/2> with formaldehyde and introducing or modifying the group R if desired and optionally converting any base into a salt. The amides of the last general formula above or salts thereof are obtained by condensing an acid of general formula <FORM:1114397/C2/3> with ammonia or an amine of formula RNH2 and removing the N-benzyloxycarbonyl group. Pharmaceutical compositions having analgesic, antiphlogistic, inflammation-inhibiting and anti-allergic activity and in conventional forms for oral, rectal, topical, percutaneous or parenteral administration comprise an above novel compound and a compatible pharmaceutical carrier, optionally with usual additives.
Patent ES-351150-A1 (ES)
Title: A drive device for a toy
IPC: A63H11/10
Filed: 1968-02-20
Abstract: A drive device for a toy has a spindle 7 on which is mounted one end of a spring 11 for frictional attachment thereto when the spring is wound up or tensioned, the spring, when in use being anchored to the toy at its other end, the spindle also being attached to a braking device which is in the form of a cylindrical casing 1 filled with a viscous fluid and containing a vane device 10 on a spindle 8 rotatable in the casing but, in use, non rotatably mounted in the toy, the cyindrical casing itself acting as a rolling surface and traction means. A regular drive speed is thus produced. The inner end of the spring 11 terminates in a loop 12 which when the spring is tensioned grips flat faces 13 formed on a boss 5 of the spindle 7. If the spring is untensioned, however, and then is wound in the wrong direction the loop will slide loosely about about the spindle, thus avoiding damage to the spring. The toy may rest on two rounded pins 23 in addition to the casing 1.
Patent ES-352037-A1 (ES)
Title: Process for the Preparation of Certain Anilines
IPC: A01N/
Filed: 1968-03-27
Abstract: Acaricidal compositions comprise as active ingredient a 2,2,2-trichloroethylidene aniline of the formula: in which Hal is fluorine, chlorine or bromine, R is alkyl and/or nitrile, x is 0,1,2,3,4 or 5, y is 0, 1 or 2, z is 0,1,2 or 3, x being at least 1 when y is 0, y being at least 1 when x is 0, and x+y+z being not more than 5, prepared by reacting an amine of the formula: with chloral of the formula: CCl 3 CHO. in the presence of at least the stoichiometric amount of chloride or anhydride of an inorganic acid, together with a carrier or diluent. The composition may be in the form of solutions, emulsions, suspensions, powders, pastes and granulates. Many active ingredients and carriers and diluents are specified.
Patent ES-356076-A1 (ES)
Title: Tomato product and method of making same
IPC: A23L27/60
Filed: 1968-07-12
Abstract: In the manufacture of tomato ketchup, whole tomatoes are broken and the surface is heated within 10 seconds of the breaking to a temperature, preferably at least 190 F., sufficient to inactivate pectinase enzyme and transporting these broken pieces to provide a flowing stream which is heated to a temperature sufficient to inactivate pectinase enzyme, this temperature being reached within 30 seconds of the commencement of the heating, for example by contact with steam. The breaking may be effected in a hammer mill without a screen, preferably beneath the surface of a bed of heated pieces recycled from the flowing stream, which simultaneously serves to effect the heating of the surface of the broken tomatoes. The product thus obtained may be further processed by comminuting the fragments with concomitant removal of stems and seeds, concentrating to at least 20 wt. per cent. solids, adding ketchup ingredients such as vinegar, sugar, salt, and spices, heating to at least 150 F., and packaging.
Patent ES-357936-A1 (ES)
Title: Novel delta**4,9,11-gonatrienes
IPC: C07J1/00
Filed: 1968-09-07
Abstract: The invention comprises compounds of formul[mu] wherein R is hydrogen and R1 is C 2-4 alkyl or R is methyl and R1 is C 1-4 alkyl, and n is 2-4. Compounds of Formula I are prepared by acid hydrolysis of compounds of Formula III which themselves are obtained by reaction of the corresponding 17-one with an appropriate organo - magnesium, - zinc, or - aluminium compound. 3,3 - Ethylenedioxy - 13# - propyl - gona- 4,9,11 - trien - 17 - one is prepared from the corresponding 3,17-dione by reaction with ethylene glycol. The compounds of Formula I possess progestomimetic activity and may be made up with suitable vehicles into pharmaceutical preparations which may be administered orally, parenterally or rectally.
Patent ES-358655-A1 (ES)
Title: Certain pyridyl-thiazolinyl phosphates and the corresponding phosphorothioates
IPC: A01N57/16
Filed: 1968-09-28
Abstract: Pyridyl-(2)-phosphates and phosphorothicates are disclosed which have in 5-position at the pyridine nucleus a thiazolinyl-(2) grouping and which are insecticidal and acaricidal agents useful in the control of insects and Acarinae, and more particularly of cattle ticks. Compositions containing these novel compounds, methods for controlling insects and Acarinae therewith, and novel 2-hydroxy- and 2-mercapto-5-thiazolinyl-(2')-pyridines useful as intermediates in their production are also described.
Patent ES-361698-A1 (ES)
Title: Use of carbides and hydrides as blowing agents for
IPC: C04B28/04
Filed: 1968-12-20
Abstract: Prepn. of foamed plastic materials comprises either (a) uniformly dispersing finely-divided, gas-providing carbides and/or hydrides, and water-contng. finely divided fillers each in a part of the anhydrous material to be foamed, and then combining the two mixtures, or (b) enclosing finely divided, gas-providing carbides and/or hydrides in a protective film which dissolves in the material to be foamed, and then dispersing the coated pdt. in the material to be foamed. - The proces enables gas-providing carbides and hydrides to be used in the prodn. of foamed plastic materials, esp. contg. mineral fillers. The pdts. are uniformly foamed, have a high strength, and are useful for the prodn. of self-supporting building materials.
Patent ES-377967-A1 (ES)
Title: Improvements in or relating to articulated tables for enamelling baths
IPC: C23D5/00
Filed: 1970-03-25
Abstract: An articulated table for hot enamelling of a bath 1 and similar castings comprises a cradle 3 pivotable about an axis X the cradle carrying a drive shaft 13, the drive shaft having a platform 14 thereon which rotates a bearer 8 for the bath about an axis Z, the platform having mounted thereon means for displacing the bearer 8 along the axis U independently of the angular position of the drive shaft 13. The cradle is moved about the axis X by means of a motor Ml, motors MT, MR and their ancillary equipment acting as a counterweight for the bath and its support The movement of the bearer 8 along the line U is provided by a double crank arrangement driven by the motor MT through a differential gear 45 shaft 25 which is coaxial with shaft 13 and a gear 26. Gear 26 drives gear 27 which is rigid with arm B1 and rotates on shaft 15. This causes the arm B1 of the double crank B1, B2 to move and gear wheel 32 rotatably mounted on shaft 33 of arm B1 walks around gear wheel 31 fixed to fixed shaft 15. Rotation of gear wheel 32 causes rotation of gear wheel 34 and hence arm B2. This produces movement of the bearer 8 along the line U and arms Cl and C2 are driven from the movement of bearer 8 and act only to maintain a straight line motion. Arms B3 and C3 support a counterweight which prevents eccentric weight about the axis 7. The weight 51 may be interchangeable. Motor MR provides drive for rotation of the platform 14 and hence the bath and counterweight about the axis 7. If the motor MT is stationary then shafts 13 and 25 rotate together due to the differential 45 and hence pure rotational movement is produced about the axis Z. In a modification (Fig. 8) the axis X passes through the journals 4 and through the centre of gravity of the bath. Quadrant gear 63 on the cradle is driven by a quadrant gear 64 driven from a motor M1 through a gearwheel 72 and a rod 68 pivoted at 71 and 69.
Patent ES-379507-A1 (ES)
Title: Releasable tube couplings
IPC: F16L37/12
Filed: 1970-05-09
Abstract: Locking members, e.g. arms 3a of clamping member 3, Fig. 1, are engaged with an inclined surface of a collar inserted in a socket 1, e.g. conical surface 2a, when a tube 4 is moved so as to remove it from the socket, thereby clamping the tube within the socket. As shown the socket has four concentric stepped bores 1a- 1d, the first containing the collar 2 bearing the inclined surface 2a, the second containing a sealing ring 5, and the last two locating the end of the tube 4. The clamping member 3 comprises a ring and a plurality of flexible, axially extending arms bearing teeth 3c at their ends. On insertion of tube 4 the teeth 3c lightly engage the pipe walls and the clamping member 3 slides axially within the collar 2. On attempted withdrawal of the pipe the ends 3a of the arms engage the surface 2a and are cammed inwardly causing the teeth to bite into and clamp the tube. To release the coupling the end 3 of the clamping member is pushed into the socket and the tube 4 withdrawn. The socket 1 may be of metal or plastics material, and the collar 2 may be screwed or pushed into bore la. In one form the collar 2 (Fig. 2) comprises cylindrical portions 8, 10, the latter being a forced fit in the socket, and a projection 11 may be provided. The collar 2, clamping member 3 and sealing ring 5 are assembled on a mandrel 13 (Fig. 6) and the collar is forced into the socket 7 by tool 19. Knife edges 20 may be provided on the tool to upset material from the socket to hold the collar, the mandrel being subsequently withdrawn prior to insertion of the tube 4, (the ends 15 of the mandrel being flexible to enable it to pass through member 3). A free fitting collar may be used, secured only by upsetting the socket material. The clamping member 3 may be of metal or metal coated plastics, or may alterntaively be of plastics material with metal insert strips (28a), (28b) (Figs. 18, 19) (not shown) embedded in it. In the latter case the ends of the strips (28a), (28b) are bent to form the teeth (29), (30) which engage the pipe 4. The ends (33) of the clamping arms 3 (Fig. 20) (not shown) may be angled to contact the sealing ring 5 such that the ring 5 assists opening of the member 3 when releasing the tube (not shown). An auxiliary ring (42) (Fig. 22) (not shown) may have arms 43 extending between the clamp arms to prevent over-tightening of the joint resulting in damage to the pipe 4. Over-tightening may also be prevented by abutment of a ring (36) (Fig. 21) (not shown) against the internal end of the collar 2 to prevent further axial movement of the clamping member 3 due to displacement of ring 5 when the tube 4 is pressurized. The conical face of ring (36) also assists expansion of member 3 on release. Release of the clamping member 3 may be by axial movement of an external sleeve (48), (54), (Figs. 26, 27), (not shown) to engage that end of the clamping member 3 which extends from the socket.
Patent ES-386402-A1 (ES)
Title: Imidazo and pyrimido{8 2,1-{11 {9 quinazoline compounds
IPC: C07D265/26
Filed: 1970-12-12
Abstract: Novel compounds of the Formulae I and II wherein R 1 is hydrogen, halogen, trifluoromethyl, C 1-4 alkyl, C 1-4 alkoxy, C 2-4 alkanoyl, sulphamoyl or hydroxy R 2 is hydrogen, C 1-4 alkyl or C 2-4 alkanoyl R 3 is C 1-4 alkyl or C 2-4 alkanoyl and n is 1 or 2 and pharmaceutically acceptable salts thereof may be prepared by reduction of the corresponding quinazolinone III with metallic hydride, alkalation or alkanoylating to introduce R 2 and R 3 , or introducing the group R 1 into the molecule. The intermediate quinazolinone III may be prepared by reacting an isatoic anhydride IV with a 2-alkylthio-2-imidazoline or a 2-alkylthio- 3,4,5,6-tetrahydropyrimidine or reacting an N- (3-chloropropyl)-2-chloro-4H-quinazolin - 4 - one with ammonia. The isatoic anhydride IV may be prepared by reacting an anthranilic acid with phosgene or oxidizing an isatin with chromium trioxide. The 5-w-butoxy-isatin may be prepared by cyclizing with sulphuric acid N-(p-n-butoxyphenyl)-[alpha]-hydroxyiminoacetamide which in turn is prepared by reacting p-n-butoxy-aniline with chloral hydrate and hydroxylamine hydrochloride. The intermediate N-(3-chloropropyl)-2,6-dichloro-4H-quinazolin-4-one may be prepared by reacting thionyl chloride and 2,6-dichloro-4-(3- hydroxypropoxy)-quinazoline, which in turn is prepared by reacting a 1,3-propanediol with a 2,4,6-trichloroquinazoline. Pharmaceutical compositions of the compounds I and II show pharmacodynamic activity and central nervous system depressant activity when administered with pharmaceutical carriers.