Patent SG-11201811188T-A (SG)
Title: A buffer free, acid stable low dose volume rotavirus vaccine
Inventor: VADREVU KRISHNA MOHAN
IPC: A61K39/12
Filed: 2017-06-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 21 December 2017 (21.12.2017) WIP0 I PCT 0111111010 0111 inn Hol 01D 0111 X10111110 oimIE (10) International Publication Number WO 2017/216808 Al (51) International Patent Classification: A61K 39/15 (2006.01) A61K 39/12 (2006.01) (21) International Application Number: PCT/IN2017/050237 (22) International Filing Date: 13 June 2017 (13.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 201641020675 16 June 2016 (16.06.2016) IN (71) Applicant: BHARAT BIOTECH INTERNATIONAL LIMITED [IN/IN]; Genome Valley, Turkapally, Shameer- pet, Hyderabad 500078 (IN). (72) Inventors: VADREVU, Krishna Mohan; Bharat Biotech International Limited, Genome Valley, Turkapally, Shameerpet, Hyderabad 500078 (IN). PRASAD, Sai De- varajulu; Bharat Biotech International Limited, Genome Valley, Turkapally, Shameerpet, Hyderabad 500078 (IN). ELLA, Krishna Murthy; Bharat Biotech International Limited, Genome Valley, Turkapally, Shameerpet, Hyder- abad 500078 (IN). (74) Agent: HASAN, Afzal et al.; Hasan and Singh, Flat No. 04, Sree Nilayam Apartment, Plot No. 12, Camelot Layout (Near Chirec Public School), Kondapur, Hyderabad 500084 (IN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) cc O cc N O C (54) Title: A BUFFER FREE, ACID STABLE LOW DOSE VOLUME ROTAVIRUS VACCINE (57) : A buffer free, acid stable, low dose volume rotavirus vaccine is disclosed. The vaccine is available in dose volume of less than 1 ml per dose for oral administration and it is without any buffer. The vaccine also does not require pre or post administration of any antacid at the time of oral administration of the vaccine to the subject to neutralize the stomach acid. The vaccine exemplifies nominal drop in vaccine titer at pH 2-4 for a time span of 30 minutes. The vaccine is stable at -20°C for at least 60 months.