baber/WOPTO huggingface dataset:
Patent AU-2016206314-B2 (AU)
Title: Methods and compositions for cell attachment and cultivation on planar substrates
Inventor: CHEN YA XIONG
IPC: C12N5/0735
Filed: 2016-07-21
Granted: 2018-03-01
Abstract: The present invention is directed to methods for the growth, expansion and differentiation of pluripotent stem cells on planar substrates lacking an adlayer and a feeder cell layer.
Patent AU-2016232142-B2 (AU)
Title: Method for manufacturing furan-2,5-dicarboxylic acid (FDCA) from a salt solution
Inventor: VAN KRIEKEN JAN
IPC: C07D307/68
Filed: 2016-03-17
Granted: 2018-09-27
Abstract: The invention pertains to a method for manufacturing furan-2,5-dicarboxylic acid (FDCA) by converting a furan-2,5-dicarboxylate salt (MFDC) into furan-2,5-dicarboxylic acid (FDCA), comprising the steps of combining an aqueous solution of MFDC with a concentration of at least 5 wt.% with an inorganic acid (HY), to form a reaction mixture comprising solid FDCA in a concentration of 1-15 wt.% in a solution of a salt resulting from the cation of the furan-2,5-dicarboxylate salt and the anion of the inorganic acid (MY solution), removing solid FDCA from the reaction mixture in a solid/liquid separation step, and providing part of the MY solution resulting from the solid/liquid separation step to the step of combining MFDC with HY. The step of providing part of the MY salt solution resulting from the solid/liquid separation step to the step of combining MFDC with HY makes it possible to obtain a stable and economic process which results in an FDCA product with good quality, and obtained in high yield.
Patent AU-2016253585-B2 (AU)
Title: Solar hot water and recovery system
Inventor: GRABOSKI TIMOTHY MICHAEL
IPC: F24S10/30
Filed: 2016-11-02
Granted: 2018-10-04
Abstract: A system of capturing waste heat includes a heat recovery unit (20) having a heat exchanger (35) arranged to transfer heat between a fluid circulating in a refrigerant loop (60) and a fluid circulating in a solar loop (70) and another heat exchanger (39) arranged to transfer heat between the fluid in the solar loop (70) and a fluid circulating in a water loop (50). Controllable first, second, and third three-way valves (V1-V3) provide or prevent, depending on fluid temperatures, an A-B, B-C, and A-C flow path through the valve. The first valve (VI) is arranged in the water loop (50) upstream of the second heat exchanger (39). The second (V2) is arranged in the solar loop (70) upstream of the second heat exchanger (39). The third valve (V3) is arranged in the solar loop (70) between the first and second heat exchangers (35, 39).
Patent AU-2016284696-B2 (AU)
Title: Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds
Inventor: CHUA PENELOPE R
IPC: C12P5/02
Filed: 2016-06-24
Granted: 2021-10-28
Abstract: The present disclosure relates to the use of a maltose dependent degron to control stability of a protein of interest fused thereto at the post-translational level. The present disclosure also relates to the use of a maltose dependent degron in combination with a maltose-responsive promoter to control gene expression at the transcriptional level and to control protein stability at the post-translational level. The present disclosure also relates to the use of a stabilization construct that couples expression of a cell-growth-affecting protein with the production of non-catabolic compounds. The present disclosure further relates to the use of a synthetic maltose-responsive promoter. The present disclosure further provides compositions and methods for using a maltose dependent degron, a maltose-responsive promoter, and a stabilization construct, either alone or in various combinations, for the production of non-catabolic compounds in genetically modified host cells.
Patent AU-2016302381-B2 (AU)
Title: An orthodontic anchorage device
Inventor: ERSKINE-SMITH CRAIG MATHEW
IPC: A61C7/28
Filed: 2016-07-14
Granted: 2021-04-29
Abstract: An orthodontic anchor (10) to be attached to the surface (12) of a tooth (11 ). The anchor (10) includes a base (13) which is in the form of a plate having a surface (14) that is dually fixed to the surface (12). Base (13) is in the form of a duct portion (15) providing a through passage (16). The passage (16) receives a tube (19), through which an elongated orthodontic element, such as a wire (21 ) or a chain can pass.
Patent AU-2016317908-B2 (AU)
Title: Powered surgical drill with integral depth gauge that includes a probe that slides over the drill bit
Inventor: CARUSILLO STEVE
IPC: A61B17/16
Filed: 2016-09-01
Granted: 2021-05-27
Abstract: A drill for driving a drill bit into a solid object such as bone. The drill includes a rotor with a bore that transmits rotational movement to the drill bit. The drill bit extends through the rotor bore. A probe extends forward from the drill to measure bore depth. The probe is moveably mounted to the drill so as to extend into the rotor bore. As the drill and drill bit advance forward the probe remains static. As a result of the advancement of the drill the rotor extends over the proximal end of the probe.
Patent AU-2016343311-B2 (AU)
Title: Device for preventing spills from inside mining mills, said device maintaining a seal around bolts used to secure mill liners, and maintaining said bolts under tension by means of an elastic action
Inventor: ENDO ARRIAGADA ALVARO ENRIQUE
IPC: F16B39/24
Filed: 2016-08-30
Granted: 2021-12-23
Abstract: The invention relates to a device for preventing spills from inside mining mills, said device maintaining a seal around bolts used to secure mill liners, such that the bolt remains under tension within a range of several millimetres along the length between the head and the nut of the bolt, with the length covered by the elements compressed between the head of the bolt and the device for preventing pulp leaks in mills, exerting pressure on the washer that provides a seal against leaks from inside the mill. The device comprises one or more pairs of Belleville washers which include an annular space into which a sleeve with an inner seal is inserted. Said sleeve includes a flange of larger diameter to allow the action of the bolt on the Belleville washers, said Belleville washers exerting pressure on the washer that provides a seal against leaks from inside the mill. The length of the sleeve is greater than or equal to the total thickness of the Belleville washers at maximum compression, and the flange of the sleeve is only required if the diameter inscribed on the contact surface with the bolt is smaller than the annular diameter of the Belleville washers.
Patent AU-2016350164-B2 (AU)
Title: Soy sauce-like seasoning
Inventor: TAKEICHI Junya
IPC: A23L27/50
Filed: 2016-05-23
Granted: 2019-09-12
Abstract: A soy sauce-like seasoning containing α-ketoglutarate in an amount equal to or more than 0.3 mM.
Patent AU-2016354673-B2 (AU)
Title: An unmanned roadside signage vehicle system
Inventor: BOYLE NORMAN
IPC: E01F9/594
Filed: 2016-11-11
Granted: 2021-04-08
Abstract: There is provided an unmanned roadside signage vehicle comprising an autonomous, semiautonomous and/or remotely controllable roadside signage vehicle for various roadside signage, emergency response and maintenance applications. In accordance with one aspect, the unmanned roadside signage vehicle comprises drive motors operably coupled to driven wheels; steering coupled to the driven wheels; a controller for controlling the drive motors and steering; at least one electronic signage board for displaying roadside signage; and a data interface for receiving at least remote control instructions, the data interface operably coupled to the controller and wherein the controller is configured for controlling the drive motors and steering in accordance with the remote control instructions.
Patent AU-2016367252-B2 (AU)
Title: Autoinjector with retracting needle
Inventor: YOUNG MATTHEW
IPC: A61M5/20
Filed: 2016-12-09
Granted: 2021-10-07
Abstract: An automatic drug delivery device is described, comprising: a housing(1);a skin sensor element (15) coupled to the housing and movable relative to the housing, wherein the skin sensor element is biased into a front position relative to the housing and is movable to a rear position relative to the housing when the skin sensor element is pressed against an injection site;a needle assembly comprising a hypodermic needle(11), the hypodermic needle extending outside of the housing when the device is in a needle insertion configuration; a drug delivery mechanism comprising a stored energy source(4), within the housing;where in the drug delivery mechanism is released when the skin sensor element is moved from the front position towards the rear position and wherein the stored energy source is arranged to expand along an axis that is offset from an axis of travel of the needle assembly in use;a needle retraction mechanism configured to withdraw the hypodermic needle into the housing when the needle retraction mechanism is released;wherein the needle retraction mechanism is coupled to the skin sensor element such that when the skin sensor element is moved from the rear position towards the front position, and the needle is in the needle insertion position, the needle retraction mechanism is released.
Patent AU-2016370711-B2 (AU)
Title: Patch for sealing retinal breaks and associated devices, systems, and methods
Inventor: GUNN NICHOLAS MAX
IPC: A61F9/00
Filed: 2016-12-08
Granted: 2021-04-01
Abstract: Systems, apparatuses, and methods of and for an ophthalmic surgical system are disclosed. In an exemplary implementation, an ophthalmic surgical system includes a patch sized and shaped to seal a retinal break of an eye by preventing fluid from infiltrating a sub-retinal space when adhered to the retina surrounding the retinal break; and a delivery device including a cannula configured to maintain the patch in a furled state for passage through an incision in the eye, the delivery device actuatable to deploy the patch within a vitreous chamber of the eye. In another exemplary implementation, an ophthalmic surgical method includes damaging tissue around a retinal break; delivering, into the vitreous chamber, a patch sized and shaped to seal the retinal break; positioning the patch on the retina surrounding the retinal break; and affixing the patch to the retina such that the patch prevents fluid from infiltrating a sub-retinal space.
Patent AU-2016372691-B2 (AU)
Title: Apparatus for making a beverage, in particular for a beverage containing milk
Inventor: DIAMANTI MAURIZIO
IPC: A47J31/44
Filed: 2016-11-23
Granted: 2021-08-12
Abstract: This disclosure relates to an apparatus (1) for making a beverage, in particular a beverage containing milk. The apparatus (1) comprises a machine body, a milk container (2) and a milk frothing device (3) for mixing milk with air and steam. The milk frothing device (3) is removably mountable in a seat (10) in an outer wall (11) of the machine body. The milk container (2) is removably couplable to the milk frothing device (3). The apparatus (1) also comprises a locking member (5) for locking the milk frothing device (3) in the mounted condition. The milk container (2) interacts with the locking member (5) in such a way that, when the milk container (2) is coupled to the milk frothing device (3) in the mounted condition, the locking member (5) is active and prevents removal of the milk frothing device (3) from the seat (10), and in such a way that, when the milk container (2) is uncoupled from the milk frothing device (3), the locking member (5) may adopt the inactive condition for allowing removal of the milk frothing device (3) from the seat (10). Therefore, the milk frothing device (3) and the milk container (2) in the coupled condition are not simultaneously removable from the machine body.
Patent AU-2017200115-B2 (AU)
Title: Human antigen binding proteins that bind beta-Klotho, FGF receptors and complexes thereof
Inventor: HU SHAW-FEN SYLVIA
IPC: C07K19/00
Filed: 2017-01-09
Granted: 2019-05-02
Abstract: The present disclosure provides compositions and methods relating to or derived from antigen binding proteins activate FGF21-mediated signaling. In embodiments, the antigen binding proteins specifically bind to (i)3 -Klotho; (ii) FGFRIc, FGFR2c, 5 FGFR3c or FGFR4; or (iii) a complex comprising j-Klotho and one of FGFRIc, FGFR2c, FGFR3c, and FGFR4. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, the antigen binding proteins are fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to (i) -Klotho; (ii) FGFRIc, 10 FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising j-Klotho and one of FGFRIc, FGFR2c, FGFR3c, and FGFR4. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods 15 of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.
Patent AU-2017201649-B2 (AU)
Title: Xenoantigen-displaying anti-cancer vaccines and method of making
Inventor: SUCHECK STEVEN J
IPC: A61K47/44
Filed: 2017-03-10
Granted: 2018-05-17
Abstract: XENOANTIGEN-DISPLAYING ANTI-CANCER VACCINES AND METHOD OF MAKING Compositions, methods of making, and methods of using, xenoantigen-displaying anticancer vaccines are described. In another broad aspect, there is provided herein a method of synthesizing an alkynefunctionalized composition of claim 1, comprising: deprotecting and ester comprising a Fmoc moiety to form a free acid; coupling the fee acid of step (a) with an amine; and removing the Fmoc moiety, and coupling the remaining moiety with palmitic acid to yield an alkyne-functionalized composition.
Patent AU-2017206039-B2 (AU)
Title: Solid forms of 2-(4-chlorophenyl)-N-((2-2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl)-2,2-difluoroacetamide, and their pharmaceutical compositions and uses
Inventor: FERNANDEZ PAUL F
IPC: C07D417/14
Filed: 2017-01-06
Granted: 2021-03-25
Abstract: Solid forms comprising 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide, compositions comprising the solid forms, methods of making the solid forms and methods of their uses are disclosed.
Patent AU-2017212260-B2 (AU)
Title: Lithium-selective permeable membrane, lithium recovery device, lithium recovery method and hydrogen production method
Inventor: HOSHINO TSUYOSHI
IPC: C22B26/12
Filed: 2017-01-26
Granted: 2019-09-12
Abstract: In order for Li ions in a stock solution to be recovered at a high recovery speed in a recovery liquid, this selectively permeable membrane (10) is configured from a selectively permeable membrane main body (10A) configured from: a lithium superionic conductor (an ion conductor) having an especially high ionic conductivity; and a Li adsorption layer (10B) which is formed as a thin layer on the selectively permeable membrane main body (10A) facing the stock solution (100) (on first electrodes (11)). A lithium lanthanum titanate specifically can be used as the material configuring the selectively permeable membrane main body (10A). By chemically treating said selectively permeable membrane main body (10A), the Li adsorption layer (10B) is formed as a thin layer on the surface of the selectively permeable membrane main body (10A).
Patent AU-2017268842-B2 (AU)
Title: Peptides and nanoparticles for intracellular delivery of genome-editing molecules
Inventor: DIVITA GILLES
IPC: C12N15/113
Filed: 2017-05-26
Granted: 2022-08-11
Abstract: The present invention pertains to peptide-containing complexes/nanoparticles that are useful for stabilizing and/or delivering one or more molecules of a genome-editing system, such as proteins and/or nucleic acids, for example CRISPR proteins and/or nucleic acids.
Patent AU-2017269046-B2 (AU)
Title: Process for the preparation of drug delivery systems having a testosterone compound present in an outer layer or part, as well as such drug delivery systems
Inventor: DE LEEDE LEONARDUS GERARDUS JOZEF
IPC: A61K31/506
Filed: 2017-05-23
Granted: 2022-11-10
Abstract: The invention relates to a process for preparing a time controlled, immediate release drug delivery system for oral administration of a first active ingredient to a subject in need thereof. The invention additionally relates to a dual drug delivery device, comprising the time controlled, immediate release drug delivery system according to the invention, further comprising a spray coating comprising a testosterone.
Patent AU-2017276170-B2 (AU)
Title: Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of Hepatitis B
Inventor: VANDYCK KOEN
IPC: C07D207/40
Filed: 2017-12-12
Granted: 2019-07-11
Abstract: Abstract SULPHAMOYLPYRROLAMIDE DERIVATIVESAND THE USE THEREOF AS 5 MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B Inhibitors of HBV replication of Formula (IA) Ra R X N R b N-SH R. I<) R5 O X'N\ 4 (A) 10 0R4 including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, Ra to Rd and R4 toR h ave the meaning as defined herein. The present invention also relates to processes for preparing said compounds, 15 pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
Patent AU-2017285224-B2 (AU)
Title: Genetically modified cells, tissues, and organs for treating disease
Inventor: HERING BERNHARD J
IPC: A01K67/027
Filed: 2017-06-14
Granted: 2023-05-18
Abstract: Genetically modified cells, tissues, and organs for treating or preventing diseases are disclosed. Also disclosed are methods of making the genetically modified cells and non-human animals. The genetic modification may include a nucleic acid that is transcribed as a human leukocyte antigen G (HLA-G) mRNA comprising a deletion in the 3 ' untranslated region, or a nucleic acid comprising a CD47 gene that is codon-optimized for expression in pig cells.
Patent AU-2017339844-B2 (AU)
Title: Patient interfaces
Inventor: PATEL ROHEET
IPC: A61M16/06
Filed: 2017-10-05
Granted: 2023-01-05
Abstract: A mask assembly can include a mask seal. In some configurations, the mask assembly can be configured to be fully positioned lower than a bridge of a nose of a face of a user and to provide an exposed bridge of the nose of the user. The mask seal can comprise a nasal region comprising at least one nasal opening, a first paddle on a first side of the nasal region and a second paddle on a second side of the nasal region. The first paddle is configured to contact one side of the nose of the user and the second paddle is configured to contact the other side of the nose of the user.
Patent AU-2017363484-B2 (AU)
Title: Embossed multi-ply tissue product
Inventor: BAUM TAMMY LYNN
IPC: D21H27/42
Filed: 2017-11-08
Granted: 2022-12-08
Abstract: The present invention provides a method of producing a decorative tissue product, while controlling tensile degradation in a predicable fashion. The foregoing properties may be achieved using differential depth embossing in conjunction with an embossing pattern having particular characteristics. The use of an engraved roll, such as an embossing roll, having protuberances of differing depths and patterns not only improves the properties and characteristics of the fibrous structure, but may also be used to impart a unique pattern that provides the product with a distinctive look and is appealing to consumers. Generally the unique pattern results from a first set of protuberances having a first height and defining a first pattern and a second set of embossing elements having a second height and defining a second pattern, where the first height is greater than the second height.
Patent AU-2017376544-B2 (AU)
Title: Oral preparation of glucokinase activator and preparation method therefor
Inventor: CHEN LI
IPC: C07D413/14
Filed: 2017-12-14
Granted: 2021-02-04
Abstract: The present invention relates to a solid dispersion and a preparation method therefor. The solid dispersion contains a glucokinase activator, an isotopic label thereof, or a medicinal salt thereof and a polymer support. The present invention further relates to a solid dispersion composition containing the solid dispersion and an excipient. The present invention also relates to an oral preparation of the glucokinase activator, containing the solid dispersion or the solid dispersion composition. The present invention also relates to a tablet and a capsule of the glucokinase activator and a preparation method therefor. In addition, the present invention also relates to uses of the solid dispersion, the solid dispersion composition and the oral preparations comprising the tablet and the capsule, which can be used for treating and/or preventing selected diseases or medical conditions and especially one or more diseases selected from type I diabetes mellitus, type II diabetes mellitus, impaired glucose tolerance, impaired fasting glucose and hyperglycemia.
Patent AU-2017382998-B2 (AU)
Title: Methods and systems for handling fresh concrete
Inventor: BEAUPRÉ DENIS
IPC: G01N33/38
Filed: 2017-12-20
Granted: 2023-01-19
Abstract: The method of handling fresh concrete generally includes the steps of receiving a viscosity value of the fresh concrete and a pressure value of a pressure exerted on a Theological probe moving in the fresh concrete; using a processor, accessing at least two calibration data sets, the at least two calibration data sets including combinations of different reference pressure values and associated reference workability values for a corresponding one of at least two reference viscosity values; determining a viscosity difference value by comparing the received viscosity value to the at least two reference viscosity values; and determining a workability value of the workability of the fresh concrete based on the reference workability values associated with reference pressure values corresponding to the received pressure value in the at least two calibration data sets and on the viscosity difference value; and handling the fresh concrete based on the determined workability value.
Patent AU-2017444938-B2 (AU)
Title: A multi-agent shared machine learning approach for real-time battery operation mode prediction and control
Inventor: HENRI GONZAQUE
IPC: G06Q10/04
Filed: 2017-12-28
Granted: 2023-12-14
Abstract: A method, system, and device for controlling energy storage devices are provided, the method including receiving a trained machine learning model from a centralized machine learning system, recording temporal data for a respective energy storage device, periodically transmitting the temporal data to the machine learning system, performing a mode prediction for controlling the energy storage device using the trained machine learning model and the temporal data, and sending a control signal to the energy storage device to operate in the predicted mode. The machine learning system aggregates the temporal data transmitted by each agent and uses the aggregated temporal data to update the machine learning model. By using aggregated temporal data, less data is needed from an individual energy storage device so that when a new energy storage device joins the machine learning system, the new energy storage device can benefit from increased performance with less computation.
Patent AU-2018200111-B2 (AU)
Title: Optimised subcutaneous therapeutic agents
Inventor: HENRY WILLIAM
IPC: A61P31/00
Filed: 2018-01-05
Granted: 2019-11-07
Abstract: Methods and dosage formulations are provided for subcutaneous administration in which therapeutic agents are modified to increase the hydrophilicity and molecular dimensions in relation to the native state of the therapeutic agent, in which the Cmax:Caverage ratio is lower than the Cmax:Caverage ratio of the 5 agent when delivered intravenously. wi. U, .- 0 0- -- - - - -- - -C _L LL H- E - I __ U- .. _ IL (n Ccc L..0 U'X U- LH