baber/WOPTO huggingface dataset:
Patent NZ-579469-A (NZ)
Title: Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
Inventor: WANG PETER X
IPC: C07D489/02
Filed: 2008-03-06
Abstract: Disclosed is a process for the preparation of a quaternary derivative of a tertiary N-substituted morphinan alkaloid having a C(3) hydroxy substituent, the process comprising (i) combining a tertiary N-substituted morphinan alkaloid substrate with an alkylating agent in an anhydrous solvent system to form a reaction product mixture containing the quaternary derivative of the tertiary N-substituted morphinan alkaloid substrate and any unreacted tertiary N-substituted morphinan alkaloid substrate, the solvent system comprising an anhydrous aprotic dipolar solvent with the aprotic dipolar solvent constituting at least 25 wt.% of the solvent system, and (ii) adding an anhydrous acid to the reaction product mixture to suppress ionization of the C(3) hydroxy substituent and production of C(3) alkoxy side products. Also disclosed is a process for the preparation of a quaternary derivative of a tertiary N-substituted morphinan alkaloid, the process comprising: (i) adding less than 3 equivalents of a solution of an alkylating agent dissolved in an anhydrous dipolar aprotic solvent to a tertiary N-substituted morphinan alkaloid substrate dissolved in an anhydrous solvent system, to form a reaction product mixture containing the quaternary derivative of the tertiary N-substituted morphinan alkaloid substrate and any unreacted tertiary N-substituted morphinan alkaloid substrate, the rate of addition of the alkylating agent being less than 0.02 equivalents of alkylating agent per equivalent of substrate per minute based upon the concentration of substrate in the reaction mixture; wherein the solution of the alkylating agent is maintained at a temperature below about 0 deg C and is added to the reaction mixture at a temperature of between about 50 deg C and about 85 deg C so as to inhibit O-alkylation at the C(3) hydroxide to less than 10% and inhibit evaporative loss of alkylating agent; and, (ii) adding an anhydrous acid to the reaction mixture to enhance product formation and inhibit side products when the substrate contains a C(3) hydroxy substituent.
Patent NZ-580788-A (NZ)
Title: Footwear for postural training
Inventor: BAIN DAVID WILLIAM
IPC: A43B3/00
Filed: 2009-10-29
Abstract: An article of footwear 10 which comprises a flexible upper designed to give good support to and conform to the shape of the wearer's foot, and a series of fluid-filled sacs 12, 13, 14, 15, 16, 17 aligned along the length of the underside of the article of footwear, where each sac extends across the full width of the weight-bearing portion of the underside of the article of footwear, and the sacs 12, 13, 14, 15, 16, 17 are arranged so that no part of any of the sacs lies under the arch of the wearer's foot when in use.
Patent NZ-584518-A (NZ)
Title: Variable-size bed
Inventor: LINDH CLAES
IPC: A47C17/80
Filed: 2008-10-23
Abstract: Disclosed is a variable-size bed comprising a mattress core and a base. The base is adapted to support at least a portion of the mattress core, wherein the mattress core and base have adjustable widths or lengths and each of the mattress core and base is changeable between an expanded state and a contracted state corresponding to an expanded state and a contracted state of the bed, respectively. The bed further comprises a cover means adapted to provide covering over the mattress core in both the expanded state and the contracted state of the bed. Also disclosed is a vehicle comprising such a variable-size bed.
Patent NZ-585835-A (NZ)
Title: Chemically modified factor IX comprising a hydrophilic polymer attached via a releasable linker
Inventor: TURECEK PETER
IPC: C12N9/64
Filed: 2008-12-19
Abstract: Disclosed is a blood coagulation factor IX (FIX) with a FIX activation peptide region (AP region), wherein said AP region comprises a covalently coupled water-soluble hydrophilic polymer, said polymer being absent from biologically produced FIX, and wherein said water-soluble hydrophilic polymer is attached to FIX via a releasable linker, especially a hydrolysable linker.
Patent NZ-589984-A (NZ)
Title: Measuring device with extensible cord and method
Inventor: SWANSON WILLIAM ROBERT
IPC: G01B5/00
Filed: 2009-06-18
Abstract: 589984 A measuring device generally comprises a base unit housing with an extensible cable. The cable has a free end for placement by a user at a point being measured. The base unit is placed in line of sight of the point being measured and includes a base, a first carriage rotationally attached to the base about a turn axis, and a second carriage rotationally attached to the first carriage about a pitch axis. Servo motors rotate the carriages to align them with cable path to the point. The turn angle, the pitch angle and the cable length are measured to determine the point's location. A plurality of points determines a surface. The user uses a programmed PDA with a radio to communicate with the base unit.
Patent NZ-590542-A (NZ)
Title: Substituted pyridazine carboxamide compounds as kinase inhibitor compounds
Inventor: LIANG CONGXIN
IPC: A61K31/58
Filed: 2009-06-18
Abstract: Disclosed are substituted pyrimidinyl carboxamide compounds of formula I, salts thereof, and methods for their preparation. Specific examples of compounds of formula I include: { 6-amino-5-[(2,6-dichloro-3-fluorophenyl)ethoxy]pyridazin-3-yl} -6-morpholin-4-ylpyridin-3-yl-carboxamide, 6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-pyridazin-3 -yl-N-(pyridin-4-yl)carboxamide, and { 6-amino-5-[(2,6-dichloro-3-fluorophenyl)ethoxy]pyridazin-3-yl} -N-(1-ethyl-6-oxo-1,6-dihydro-pyridin-3-yl))carboxamide Compounds of formula I are useful for treating or preventing disease or disease symptoms associated with or mediated by protein kinase modulation activity, such as the c-met, ron or ALK or fusion proteins. Such diseases include lung, colon, breast, prostate, liver, pancreas, brain, kidney, ovaries, stomach, skin, and bone cancers, gastric, breast, pancreatic cancer, glioma, lymphoma, neuroblastoma, and hepatocellular carcinoma, papillary renal carcinoma, or head and neck squamous cell carcinoma.
Patent NZ-590861-A (NZ)
Title: 5-phenyl-isoxazole-3-carboxamides modulating hsp90 with antitumoral activities
Inventor: GIANNINI GIUSEPPE
IPC: C07D498/04
Filed: 2009-06-30
Abstract: Disclosed herein are aryl isoxazole derivatives of formula I wherein: X is halogen, alkyl, alkenyl, haloalkyl, aryl, heteroaryl, benzyl, amino, alkylamino, or aminocarbonyl; Y and Z, the same or different, are halogen, nitro, haloalkyl, R3, OR3, amino, alkylamino, or aminocarbonyl; R1 is NHC(=O)ER4, NHC(=S)ER4, or NR5R6; R2 is NR8R9; and additional substituents are define in the specification; which exhibit inhibition of the molecular chaperone heat shock protein 90 (Hsp90) for use in the treatment of a neurodegenerative disease, inflammatory disease, cancer, autoimmune disease, cerebral ischemia, parasitemia including malaria. Examples of neurodegenerative diseases include Parkinson disease, Huntington disease, Alzheimer disease, dementia with Lewy bodies, amyotrophic lateral sclerosis, spinal and bulbar muscular atrophy or spinocerebellar ataxia. Examples of compounds claimed include: 4-acetylamino-5-(5-chloro-2,4-dihydroxy-phenyl)-isoxazole-3-carboxylic acid ethylamide; 5-(5-chloro-2,4-dihydroxy-phenyl)-4-(2,2-dimethyl- propionylamino)-isoxazole-3-carboxylic acid ethylamide; 1H-indole-6- carboxylic acid [5-(2,4-dihydroxy-5-isopropyl-phenyl)-3-ethyl carbamoyl- isoxazol-4-yl]-amide; 4-[(4-aminomethyl-cyclohexanecarbonyl)-amino]-5-(2,4-dihydroxy-5-isopropyl-phenyl)-isoxazole-3- carboxylic acid ethylamide; and 5-(5-chloro-2,4-dihydroxy-phenyl)-4-(4-methoxy-benzoylaniino)-isoxazol-3-yl-(4-methylpiperazin-l-yl)-methanone.
Patent NZ-595813-A (NZ)
Title: Wand attachments for hand-held electric blenders with blades having different cutting paths and internal housing protrusions facing blade tip paths
Inventor: WADE ADAM
IPC: A47J43/04
Filed: 2010-04-16
Abstract: A wand-like tool (20) for a hand blender comprises an elongate, tubular housing (22) containing a rotatable drive shaft (23). The tool is adapted at one end to permit the shaft (23) to pick up rotary drive from a hand- held driver unit, and carries a foodstuff-processing head at its other end; the processing head comprising a bladed member (26), coupled to the shaft (23) and having at least three blades (32a, 32b and 32c not shown). The bladed member rotates within a processor head housing (27) having a tubular side-wall (30) formed with a roof (36) where the processor head housing (27) joins the tubular shaft housing (22) and being open at its opposite end, and the internal surface (38) of the side-wall (30) bears protrusions (40) facing the tips of the blades (32a, 32b, 32c). Each protrusion (40) presents a respective bluff body to foodstuffs flowing past it.; In some embodiments of the invention, the side-wall (30) is castellated (44, 46) and the protrusions (40) are formed only in non-castellated regions of said side-wall (30). In a preferred embodiment, the shaft housing (22) is formed of metal, such as stainless steel, whereas the head housing (27) is of plastics material, thereby to permit the protrusions (40) and the castellations (44, 46) to be readily formed by moulding, and a stainless steel dome (50) is provided to overlay the roof member (36) of the plastic housing (27) and/or the junction between the stainless steel and plastic component parts (22, 27) for cosmetic reasons.
Patent NZ-596941-A (NZ)
Title: COATING COMPOSITION for glass blowing plunger
Inventor: NEESOM EDDIE
IPC: C09D1/00
Filed: 2010-06-02
Abstract: A coating composition for coating a substrate, the coating composition comprising: Boron in an amount of between 1 and 2.5 wt%; Carbon in an amount of between about 1.5 and 3 wt%; Chromium in an amount of between about 10 and 15 wt%; Iron in an amount of between about 1 and 3 wt %; Nickel in an amount of less than about 15 wt%; Silicon in an amount of between about 1 to 3 wt% Tungsten in an amount of between about 10 to 55 wt% with the balance of wt% being Cobalt.
Patent NZ-597642-A (NZ)
Title: Wind turbine
Inventor: STIMM KEAN W
IPC: F03D1/00
Filed: 2010-06-22
Abstract: 597642 Disclosed is a wind turbine for operating at an higher efficacy than standard wind turbines. The wind turbine has a set of curved blades mounted on a central rotatable hub. An enclosure surrounds and is attached to the tips of the blades. The enclosure is arranged to rotate with the hub and the blades. The blades have a fixed pitch such that a pitch angle of each of the blades at the tip end is from 50 degrees and 75 degrees to a rotational (central) axis of the hub. A pitch angle of each of the blades at a hub end is defined by a product of a ratio, of a hub radius divided by a turbine radius, multiplied by a pitch angle at the tip. The blade is provided with a compound curve that causes the blade to fall away from an angle of apparent wind (the angle of the wind seen by the moving blade) impinging upon the blade at a wind entry location of the blade. The turbine is further provided with an apparatus that controls speed of rotation of the turbine so that the angle of the apparent wind to the blades can be adjusted relative to the pitch angle of the blades to obtain at least 50% of maximum energy that can be extracted using the turbine. A further variation of the wind turbine has the pitch angle of the leading edge of the blades at the tip end is from 54 degrees to 75 degrees to a rotational (central) axis of the hub and the pitch angle of the blade at the hub end is between 28 and 49 degrees to the rotational axis of the hub.
Patent NZ-602000-A (NZ)
Title: Methods and compositions to treat hemorrhagic conditions of the brain
Inventor: MACDONALD R LOCH
IPC: A61K38/00
Filed: 2011-02-22
Abstract: Disclosed is a site-specific, pharmaceutical composition comprising: (a) a therapeutic amount of at least one hemostatic agent, wherein at least one such hemostatic agent is an anti-fibrinolytic agent, wherein the therapeutic amount is effective to reduce hematoma expansion or recurrent bleeding resulting from a hemorrhagic condition in brain, when compared to a non-treated control; and (b) a pharmaceutically acceptable carrier, wherein the carrier comprises a plurality of microparticles comprising the therapeutic amount of the hemostatic agent dispersed throughout each microparticle, in a core of the microparticle surrounding by a coating, adsorbed into the particles, or a combination thereof, and the microparticles provide sustained release of the hemostatic agent from the microparticles at the implant site to maintain a high concentration of the hemostatic agent locally and lower concentrations in the rest of the body, thus decreasing risk of unwanted systemic side effects, wherein the composition is formulated for deposition in or on a biodegradable implant at an implant site in a cavity or space within the human brain occupied by a hematoma or in a subdural space on the surface of the brain, wherein the implant is in a form of a sheet or a string and for flowability of the hemostatic agent in cerebrospinal fluid from the implant site to a site of bleeding in or on the brain.
Patent NZ-604478-A (NZ)
Title: Fused heterocyclic compounds as ion channel modulators
Inventor: KOBAYASHI TETSUYA
IPC: A61P3/10
Filed: 2011-06-30
Abstract: The present disclosure relates to [1,2,4]triazolo[4,3-a]pyridin-3(2H)-one compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein R1 is aryl, pyridinyl, pyridazinyl, pyrimidinyl, quinolonyl, indazolyl, triazolopyridinyl, imidazopyridinyl, thiadiazolyl, or triazolyl R2, R3, R4, and R5 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same. Compounds of the disclosure are of use in the treatment of conditions related to sodium current including cardiovascular disease selected from one or more of atrial and ventricular arrhythmias, heart failure (including congestive heart failure, diastolic heart failure, systolic heart failure, acute heart failure), Prinzmetal’s (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, ischemia, recurrent ischemia, reperfusion injury, myocardial infarction, acute coronary syndrome, peripheral arterial disease, pulmonary hypertension, and intermittent claudication, diabetes or diabetic peripheral neuropathy, neuropathic pain, epilepsy, seizures, or paralysis.
Patent NZ-611363-A (NZ)
Title: Compositions and methods for treating myelofibrosis
Inventor: JAYAN ARVIND
IPC: A61P35/00
Filed: 2011-11-07
Abstract: Provided are capsules comprising N-tert-butyl-3-[(5-methyl-2-{ [4-(2-pyrrolidin-1-ylethoxy)phenyl]amino} pyrimidin-4-yl)amino]benzenesulfonamide (TG101348). In a preferred embodiment the capsule comprises TG101348 admixed with microcrystalline cellulose and sodium stearyl fumarate. The capsules are useful in the treatment of myelofibrosis.
Patent NZ-612651-A (NZ)
Title: Transmission management apparatus, program, transmission management system, and transmission management method
Inventor: IMAI TAKUYA
IPC: H04N7/15
Filed: 2012-10-18
Abstract: Disclosed is a transmission management apparatus includes a receiving unit that receives a communication request for a communication with a second transmission terminal (10) from a first transmission terminal (10). The apparatus includes a fists storage unit stores therein terminal identification information for identifying the transmission terminals (10) and relay device identification information for identifying a relay device (30) that relays data to be transmitted and received by the first transmission terminal (10). The apparatus has a relay device selecting unit selects the relay device (30) associated with the terminal identification information of the first transmission terminal (10) in the first storage unit. The apparatus also includes a second storage unit stores therein the relay device identification information and encryption necessity information in an associated manner. An encryption necessity determining unit is included to determine whether encryption is needed based on the encryption necessity information associated with the relay device (30) selected by the relay device selecting unit in the second storage unit.
Patent NZ-621449-A (NZ)
Title: Treatment with anti-vegf antibodies
Inventor: FYFE GWENDOLYN
IPC: C07K16/22
Filed: 2004-05-28
Abstract: Disclosed is the use of bevacizumab and an anti-neoplastic composition, in the manufacture of a medicament for the treatment of cancer in a human patient, wherein the anti-neoplastic composition comprises at least one chemotherapeutic agent, and wherein the human patient is to be assessed for gastrointestinal perforation. Also disclosed is the use of bevacizumab in the manufacture of a medicament for treating a human patient susceptible to or diagnosed with colorectal cancer, wherein the human patient is to be assessed for gastrointestinal perforation.
Patent NZ-710839-A (NZ)
Title: Method and reagent for preparing a diagnostic composition
Inventor: IN’T VELD DIRK-JAN
IPC: A61K49/04
Filed: 2014-03-06
Abstract: The present invention provides an aqueous, excipient solution suitable for diluting a diagnostic composition comprising a contrast agent. The excipient solution comprises a sodium ion concentration of about 100 -140 mM and a calcium ion concentration of about 0.8 - 1.2 mM. Alternatively, the molar ratio between sodium ion concentration and calcium ion concentration is between about 80 and 175. Also provided are methods of making and using the excipient solution, as well as a kit comprising the excipient solution.
Patent NZ-710939-A (NZ)
Title: Humidifier and layered heating element
Inventor: FOOTE ROGER MERVYN LLOYD
IPC: H05B3/26
Filed: 2012-06-15
Abstract: A heating apparatus (36) includes a heating element (48) which converts electrical power to heat energy, a heatable element (44) having a first surface and a second surface, and a dielectric laminate layer (46) between the heating element and the first surface of the heatable element. The dielectric laminate layer is thermally conductive to transfer heat energy from the heating element to the heatable element. The second surface of the heatable element is configured heat a liquid in a container. The heating apparatus is assembled using an automated assembly process. The heating apparatus is typically used in a humidifier.
Patent NZ-722888-A (NZ)
Title: Process for producing a food based on leavened dough, leavened puff pastry dough or puff pastry dough
Inventor: DOUAIRE PHILIPPE
IPC: A21D6/00
Filed: 2015-02-25
Abstract: Leavened, leavened puff pastry and puff pastry doughs prove by virtue of the release of carbon dioxide caused by the alcoholic fermentation of the sugars by the yeast, and of the release of water vapour during the baking phase. The proving of these doughs requires for a lengthy period of time (between one and three hours) an expensive proving chamber which consumes large amounts of energy. Furthermore, the fragility of the fresh proven dough limits the manipulation, handling and/or transportation possibilities. Surprisingly, the shape of the raw food based on leavened dough, leavened puff pastry dough or puff pastry dough, and the positioning thereof during the baking step, are essential elements to the quality of the final product obtained after baking. The present invention therefore provides a process for producing a food based on leavened puff pastry dough or puff pastry dough, comprising the following steps: (i) preparing a leavened puff pastry dough or puff pastry dough comprising flour and water, (ii) kneading the dough, (iii) fashioning the dough to obtain the raw food, wherein the method comprises the following steps: (iv) shaping at least one surface of the raw food in the shape of a single arch, or in the form of multiple, tandemly arranged arches, wherein said food product comprises two or more support points located at the ends of said food, formed by said arch or tandemly arranged arches, (v) freezing and/or deep-freezing the raw food in said arch or multiple arch shape, (vi) positioning the frozen or deep-frozen food on a baking support in a raised (up-right position) position on said at least two support points, in the shape of an arch, and baking the food product whereby the concave surface of said food is facing the baking support; or positioning the frozen or deep-frozen food on a baking support on said multiple arch-shaped surface, the more than two support points contacting the baking support in an undulated manner; and baking the food product.
Patent NZ-724819-A (NZ)
Title: Sigma-2 receptor ligand drug conjugates as antitumor compounds, methods of synthesis and uses thereof
Inventor: MACH ROBERT
IPC: C07D403/14
Filed: 2015-04-01
Abstract: Methods and compositions for treating cancers such as pancreatic cancer and synovial sarcoma are disclosed. Compounds of formula (III) comprising a sigma-2 receptor-binding moiety and a ferroptosis-inducing moiety are described. At least one described molecular species exhibits an IC50 value below 5 μΜ against human pancreatic cancer cells in vitro. Administration of this species promoted shrinkage of pancreatic cancer tumors in a murine model system in vivo, and led to 100% survival of experimental animals over a time course in which control therapies provided only 30% or 40% survival. Methods of synthesis of molecular species are also disclosed.
Patent NZ-725014-A (NZ)
Title: Internet-based search mechanism
Inventor: MORRIS STEPHEN
Filed: 2015-04-14
Abstract: The present invention discloses a system for providing an internet-based search mechanism to enable an anonymous user to search for a resource provider. The system comprises a user device adapted to host an internet-based portal such that a user can submit an anonymous request for information relating directly to a resource. A secure server adapted to host a database containing resource provider information, to communicate with the user device via a communications network and to alert at least a first resource provider is also provided, wherein the database is a component of an asynchronous search engine. The secure server is also adapted to initiate an anonymous communication channel between at least the first resource provider and the user via the internet-based portal and the communications network. A method for carrying out such a search via a user device and a secure server is also disclosed including displaying, by the user device, an option for the user to accept or reject a Universal Resource Locator wherein the anonymous communication channel is closed if the user rejects the URL.
Patent NZ-729478-A (NZ)
Title: Antibodies and chimeric antigen receptors specific for cd19
Inventor: CHEN YAN
IPC: C07K14/705
Filed: 2015-08-28
Abstract: Provided are CD19 binding molecules, including anti-CD19 antibodies, including antibody fragments such as single-chain fragments, and chimeric receptors including the antibodies, such as chimeric antigen receptors (CARs). Among the antibodies are human antibodies, including those that compete for binding to CD19 with reference antibodies, such as murine antibodies. In some embodiments, the antibodies display similar functional properties to the reference antibodies, such as comparable binding affinities and/or competitive inhibition properties. Also provided are genetically engineered cells expressing the chimeric receptors, and uses of the binding molecules and cells adoptive cell therapy.