baber/WOPTO huggingface dataset:
Patent JP-2001511080-A (JP)
IPC: B29C45/26
Filed: 1998-01-28
Abstract: The invention concerns a procedure for sequential moulding of an assembled object and a machine for the performance of the procedure. The in at least two subsequent mouldings produced object is moulded in a mould with a usually stationary front part (1), a movable back part (2) and at least one turnable middle part (3). After the moulding of the first part of the object (5), the middle part (3) is turned at least once, preferably 180 degrees around an axis/axle (4) placed in a right angle to the moving direction between the front part and the back part, before the moulding of the following part of the object (10) takes place. In this way the first part of the object from the moulding at the front part (1) can be transported via the turnable middle part (3) to the back part (2), where the following moulding on the object can take place. As well as the injection and the cooling can take place in the front part and in the back at the same time, a lot of cycle time can be saved. In a special design the middle part (3) can be equipped with an insulation (11) in the middle which secures that between the front part (1) and the middle part (3) can be maintained a higher temperature than between the middle part and the back part (2). Hereby it is possible to mould together considerably different materials such as a thermo plastic material and an elastomer, a silicone, or metal and plastic. <IMAGE>
Patent JP-H09507806-A (JP)
Title: 高解像度多色インクジェットプリンタ
IPC: B41J2/195
Filed: 1996-05-02
Abstract: (57)【要約】
回転ドラム（１４）と、該ドラム（１４）により支持された基体（２４）に沿ってドラムの軸線に対して平行な方向にスキャニングされる１対のインクジェットヘッド（２０、２２）を有する高解像度インクジェットプリンタ。ヘッド（２０、２２）はドラム駆動軸（２６）に連結された親ねじ（３６）により駆動され、制御ユニット（４４）は、ドラム駆動軸（２６）に連結されたエンコーダ（４２）から受けたエンコーダ信号の速度に対応する速度で印刷ヘッド（２０、２２）からのドロップ射出速度を制御する。一方の印刷ヘッド（２０）は、黒色、マゼンタ色、シアン色および黄色の高濃度インクを受け入れかつ該インクのドロップを射出し、他方の印刷ヘッド（２２）は、黒色、マゼンタ色およびシアン色の低濃度インクのドロップを、他のインク（濃度が異なる別の色または黒色のインクでよい）と一緒に射出する。高解像度および高品位印刷は、ドラム支持軸（２６）とドラム表面との間の距離、および、ドラム支持軸（２６）と、印刷ヘッド（２０、２２）がドラム表面に隣接して移動するときに印刷ヘッド（２０、２２）が支持されるキャリジ支持レール（８８）との間の距離を正確に制御することにより確保される。ホットメルトインクを使用する場合には、ドラム表面に隣接してヒータ（１００）を設けてドラムの表面温度をインクの融点より低い一定レベルに維持し、かつ、プリンタを包囲するハウジング（１２）にドラム温度より約１０℃低い周囲温度を維持するよう制御される温度ゾーンを設ける。
Patent JP-2001511168-A (JP)
Title: 偏頭痛の治療のためのイブプロフェンおよびドンペリドンを含有する製薬組成物
IPC: A61K31/454
Filed: 1998-02-03
Abstract: (57)【要約】
イブプロフェンまたはその塩の治療的に有効な量およびドンペリドンまたはその塩の治療的に有効な量を含有する製薬組成物を患者に投与することにより偏頭痛が治療される。
Patent JP-H11507494-A (JP)
Title: ヒステリシスのある階段状可変利得制御を具備した選択式呼受信機
IPC: H03G3/20
Filed: 1997-03-25
Abstract: (57)【要約】
入力信号を受信し、出力信号を発生する受信機（１００）は、階段状可変利得制御を備えた切換可能利得回路（１０４）と、局部発振器（１０６）と、出力信号のレベルを検出し、出力信号のレベルを表わすＡＧＣ信号を発生するヒステリシス応答を伴う自動利得制御（ＡＧＣ）検出器（１１４）と、切換可能利得回路の利得を不連続の階段状刻み幅で増加又は減少させるためＡＧＣ信号に応答して切換可能ピン回路（１１８）の階段状可変利得制御に制御信号を発生する状態機械（１１６）とを有する。
Patent JP-H11505736-A (JP)
IPC: A61F2/44
Filed: 1996-05-15
Abstract: PCT No. PCT/EP96/02092 Sec. 371 Date Nov. 24, 1997 Sec. 102(e) Date Nov. 24, 1997 PCT Filed May 15, 1996 PCT Pub. No. WO96/37170 PCT Pub. Date Nov. 28, 1996A substitute vertebra with adjustable height is provided with a sleeve-shaped central part (1) having a wall with a plurality of apertures (5, 6), the central part comprising a left-handed thread adjacent to its first edge and a right-handed thread adjacent to its second edge. A cylindrical first part (7) is connected with the one threaded portion through a corresponding thread and a cylindrical second part (9) is connected to the other threaded portion through a corresponding thread. Both parts (7, 9) also have walls with a plurality of apertures (8). The two parts (7, 9) both have a plurality of teeth (8) provided at their free edges.
Patent JP-H11511177-A (JP)
Title: 抗ウイルス性複素環式アザヘキサン誘導体
IPC: C07C271/22
Filed: 1997-04-14
Abstract: (57)【要約】
式(Ｉ * )
 [式中、Ｒ 1 は低級アルコキシカルボニルであり、Ｒ 2 は２級または３級低級アルキルまたは低級アルキルチオ−低級アルキルであり、Ｒ 3 は、非置換であるか、または１つ以上の低級アルコキシ基により置換されているフェニル、またはＣ 4 −Ｃ 8 シクロアルキルであり、Ｒ 4 は、環式炭素原子により結合している不飽和複素環により４位が各々置換され、５〜８環式原子を有し、窒素、酸素、硫黄、スルフィニル（-ＳＯ-）およびスルホニル（-ＳＯ 2 -）から選択された１〜４つのヘテロ原子を含み、および、非置換であるか、または低級アルキルまたはフェニル−低級アルキルにより置換されている、フェニルまたはシクロヘキシルであり、Ｒ 5 は、Ｒ 2 とは独立して、Ｒ 2 に記載の意味の１つを有し、Ｒ 6 は、Ｒ 1 とは独立して、低級アルコキシカルボニルである]で示される化合物、または、少なくとも１つの塩形成基が存在する場合その塩について記載する。この化合物はレトロウイルスアスパラギン酸プロテアーゼ阻害剤であり、例えば、ＡＩＤＳの処置に使用することができる。これらは際立った薬物動態特性を示す。
Patent JP-2001513685-A (JP)
Title: 植毛方法及び装置
IPC: B29C45/14
Filed: 1998-03-02
Abstract: (57)【要約】
歯ブラシ用の毛を植毛する方法が提供される。この方法は、各々が第１の丸い端部及び第２の端部を備えた歯ブラシ用の毛を有する複数の歯ブラシ用の毛を準備し、丸い端部の歯ブラシ用の毛を束状にグループ化し、歯ブラシ用の毛の束の第２の端部を成形装置の成形キャビティに挿入する工程と、前記成形キャビティ内で前記歯ブラシ用の毛の第２の端部を束に融合する工程と、前記束の融合端部を包囲するブラシヘッドを形成する工程とを有する。
Patent JP-2001513863-A (JP)
Title: 内燃機関用のスタータシステム並びに内燃機関を始動させる方法
IPC: F02N11/08
Filed: 1998-03-06
Abstract: (57)【要約】
本発明は、内燃機関のスタータシステム並びにこの種のエンジンを始動させる方法に関する。特に本発明は、次のものを有するスタータシステムに関する：電気的なスタータ（４）；充電後にスタータの始動に用いられる電気的な短時間蓄積装置（８）、特にコンデンサ蓄積装置；直接または間接的な温度検出手段；始動プロセス前に１つまたは複数の負荷に給電するために、短時間蓄積装置に蓄積されているエネルギの一部分を取り出させる制御装置であって、その場合に前記部分の大きさが温度に関係し、かつ特に温度が低い場合には温度が高い場合よりも小さい。
Patent JP-2000510065-A (JP)
Title: 曇りのないイメージ保護層
IPC: G03G7/00
Filed: 1996-05-16
Abstract: (57)【要約】
イメージ付基材にリリースライナー（図示せず）から転写する光学的に曇りのない透明な保護層１２を開示する。この層はビニル樹脂、任意のアクリル樹脂、任意の可塑剤および任意の安定剤を含有する組成を持つ。この層はまたイメージ付基材２２およびイメージ２４に圧力により接着する感圧接着剤１６を任意に含み、その後リリースライナーは剥離される。リリースライナーは１から１０のシェフィールド平滑度を持つ。この層の製造方法および使用方法もまた開示されている。イメージ２６は保護層１２と感圧接着剤１６の間にあってもよい。
Patent JP-2001516406-A (JP)
Title: 多軸性繊維ウェブを製造する方法及びその装置
IPC: D04H3/05
Filed: 1998-03-25
Abstract: (57)【要約】
複数の一方向性シート（３０ａ、３０ｂ、３０ｃ）が異なる方向に重ね合わされ、それらは一体に結合される。少なくとも１つの一方向性シートが、均一な厚さ、５cmよりも小さくない幅、および３００ｇ／ｍ 2 よりも小さくない重さを有するように、トウを広げることによって形成され、他のシートと重ね合わせる前に当該シートを取り扱うことを可能にするために、凝集状態が付与される。有利には、一方向性シートは炭素繊維からなり、大きなトウを広げることによって得られる。
Patent JP-2001518151-A (JP)
Title: フラッシュ紡糸製品
IPC: D01F6/46
Filed: 1998-03-24
Abstract: (57)【要約】
本発明はプレクシフィラメント状フィルム−フィブリル材料からつくられた不織布シート構造物に柔らかさと静謐さとを与えるフラッシュ紡糸用共重合体に関する。特にポリエチレンをエチレン共重合体と一緒にフラッシュ紡糸すると柔らかさおよび静謐さに実質的な改善が得られる。
Patent JP-2002506420-A (JP)
IPC: C07K16/28
Filed: 1997-05-19
Abstract: The invention provides mutated IgG2 constant regions and anti-CD3 antibodies incorporating the same. Such antibodies specifically bind to the CD3 antigen on T-cells but induce reduced mitogenic response compared with otherwise identical antibodies bearing natural IgG2 constant regions. The antibodies can be used for treating disorders requiring immune suppression with fewer side effects than result from treatment with prior anti-CD3 antibodies.
Patent JP-2001524238-A (JP)
Title: 印刷本用の追補情報提供方法及び装置
IPC: G06F1/10
Filed: 1998-04-24
Abstract: (57)【要約】
印刷本（12）に関連する追補情報を提供方法において、それぞれの内容を有する複数の異なる印刷本を配布し、前記複数の異なる印刷本の各々とともに共通する１つのインターネットウェブアクセスアドレス（16）を提供し、前記インターネット（20）上において前記共通するアドレスで第１のウェブサイト（10）をアクセス可能にし、第一に、前記第１のウェブサイトで、前記第１のウェブサイトへの各インターネットアクセス（18）に応答して、前記異なる印刷本のそれぞれに対応するハイパーリンク（23，25，27，および29）の第１の群を表示し、第二に、前記第１のウェブサイトで、前記第１の群のハイパーリンクのいずれか一つの選択に応答して、前記第１のウェブページの前記選択されたハイパーリンクに対応する前記印刷本の前記内容に関連し基礎となる情報を有するさらに別のウェブサイト（43，45，47，および49）をそれぞれ特定するハイパーリンクのさらに別の群を表示するステップからなる。
Patent JP-2002516633-A (JP)
Title: 新規物品
IPC: A47G19/22
Filed: 1998-04-27
Abstract: (57)【要約】
液体に関連して用いられる新規物品１０は、本体１２と、本体１２に付着されて可聴音と可視光線の様な特殊効果を電気的に発生させて使用者の楽しみを盛り上げる発電機構３４とを有する。発電機構３４には駆動機構４０が提供されるが、この駆動機構は本体１２に付着されて液体に接触することによって発電機構３４を駆動させる。本発明の一実施例に従えば、本体１２は液体通路１４を有する吸入ストローを含む。駆動機構４０は通路１４内部に位置した一対の電気接点４６、４８を有し、通路１４を通して流れる液体によって発電機構３４を駆動させる。
Patent JP-2001517237-A (JP)
IPC: A61K8/00
Filed: 1998-05-08
Abstract: Disclosed are antiperspirant cream compositions with improved dry skin feel. These antiperspirant compositions have a penetration force value of from about 20 gramxforce to about 500 gramxforce, and comprise (a) from about 20% to about 80% by weight of a volatile silicone material; (b) from about 5% to about 35% of a particulate antiperspirant active; (c) from about 0.1% to about 20% by weight of a gellant material comprising glyceryl tribehenate and other triglycerides wherein at least about 75% of the esterified fatty acid moieties of said other triglycerides have from about 18 to about 36 carbon atoms, and the molar ratio of glyceryl tribehenate to said other triglycerides is from about 20:1 to about 1:1; and (d) from about 0.1% to about 5% by weight of a drying agent selected from the group consisting of bentonite clays, hectonite clays, colloidal silicas, talc, microthene, and mixtures thereof. The compositions preferably further comprise a residue masking material.
Patent NZ-193484-A (NZ)
Title: Styryl-cyclopropanecarboxylic acid esters pesticidal compositions intermediate acids
Inventor: HAMMANN I
IPC: C07D317/52
Filed: 1980-04-21
Abstract: Substituted styrylcyclopropanecarboxylic acid esters of the formula <IMAGE>   in which R represents C1-4-alkyl or an alcohol radical customary in pyrethroids, R1 represents alkoxy or alkylthio, either of which is optionally substituted by halogen and R2 represents hydrogen or alkoxy, or R1 and R2 together represent optionally halogen-substituted alkylenedioxy, and R3 represents hydrogen or chlorine, exhibit arthropodicidal activity. A novel synthesis is shown involving reaction of   <IMAGE>   <IMAGE>   in the presence of an alkali metal cyanide to produce an end product wherein R is an alpha -cyano-3-phenoxybenzyl ester.   <IMAGE>  is reacted with <IMAGE>  in the presence of a base to produce certain novel intermediates.
Patent NZ-206354-A (NZ)
Title: Container: includes cassette of wet wipes and seal
Inventor: HOWARD J A
IPC: A47K10/38
Filed: 1983-11-22
Abstract: The invention pertains to a seal for dispensing wet wipes from a container comprising a tube of generally tapered form having a relatively wide mouth for receiving wipes and a relatively narrow orifice for dispensing them, the tube being divided circumferentially into relatively rigid and relatively flexible axially extending zones, so that when a wet wipe is dispensed the orifice is capable of expansion. The seal according to the invention provides good dispensing action and prevents to a significant extent evaporation of the impregnated liquid.
Patent NZ-214820-A (NZ)
Title: Preparing suspension fertiliser
Inventor: BUSCALL R
IPC: C05G5/00
Filed: 1986-01-14
Abstract: A process for preparing suspension fertilisers wherein nutrient material and at least one crystal growth inhibitor are mixed, potassium chloride is added, the resultant slurry mixed with subsequently a suspending aid, for example a clay, is added with mixing.
Patent NZ-214926-A (NZ)
Title: Thieno-triazolo-1,4-diazepino-2-carboxylic acid amides and pharmaceutical compositions
Inventor: WEBER K-H
IPC: C07D495/00
Filed: 1986-01-24
Abstract: 1. Thieno-triazolo-1,4-diazepino-2-carboxylic acid amides of general formula   see diagramm : EP0194416,P21,F2   wherein R1 represents hydrogen, a straight-chained or branched alkyl group having 1 to 4 carbon atoms, optionally substituted by halogen or hydroxy, cyclopropyl, alkoxy with 1-3 carbon atoms or halogen ; R2 and R3 , which may be identical or different, represent hydrogen, a straight-chained or branched alkyl or hydroxyalkyl group with 1 to 4 carbon atoms or both groups R2 and R3 together with the nitrogen atom represent a 5-, 6- or 7-membered ring which optionally contains a nitrogen, oxygen or sulphur atom as a further heteroatom, the second nitrogen atom optionally being substituted by an alkyl group with 1-4 carbon atoms ; R4 represents phenyl, wherein the phenyl ring may be mono- or polysubstituted by methyl, halogen, nitro or trifluoromethyl, or alpha-pyridyl and n represents one of the numbers 0, 1, 2, 3, 4, 5, 6, 7 or 8.
Patent NZ-214932-A (NZ)
Title: Microwave oven: rotatable, inclined plate has holders about its periphery
Inventor: LE VIET T
IPC: H05B6/80
Filed: 1986-01-24
Abstract: The invention relates to a process and an apparatus for heating foods oblong in shape. This apparatus comprises a reheating enclosure with a microwave source and an inclined preferably circular plate rotatably mounted substantially at its center on a drive shaft, in which said rotating plate comprises arranged uniformly around its periphery, at least two holders for foods perpendicular to the plane of the plate. This apparatus provides for the uniform distribution of heat throughout the treated food.
Patent NZ-223858-A (NZ)
Title: 6-oxo-prostaglandin-e 1 -derivatives and pharmaceutical compositions
Inventor: KLAR ULRICH
IPC: C07C405/00
Filed: 1988-03-11
Abstract: PCT No. PCT/DE88/00151 Sec. 371 Date Nov. 23, 1988 Sec. 102(e) Date Nov. 23, 1988 PCT Filed Mar. 11, 1988 PCT Pub. No. WO88/07037 PCT Pub. Date Sep. 22, 1988.The invention relates to 6-oxo-prostaglandin E1 derivatives of formula I,   <IMAGE> (I)  in which R1 means the radical COOR2 with R2 meaning a hydrogen atom, C1-C10 alkyl, a C5-C6 cycloalkyl or a C6-C10 aryl group or a heterocyclic radical, or the radical CONHSO2 R5 as C1-10 alkyl, C5-6 cycloalkyl or C6-10 aryl, A means an E-configuration CH=CH or a -C=C group, W means a free or functionally modified hydroxymethylene group or a free or functionally modified group, and the OH group in each case can be in the alpha or beta position, D means a straight-chain or branched-chain alkylene group with 1-5 C atoms, E means a -C=C group or a C2-C4 alkenylene group, R3 means C1-C10 alkyl, C3-C10 cycloalkyl or an optionally substituted C6-C10 aryl group or a heterocyclic group, R4 means a free or functionally modified hydroxy group, and if R2 means a hydrogen atom, its salts with physiologically compatible bases as well as alpha, beta or gamma cyclodextrin clathrates of the compounds of formula I, process for their production and their pharmaceutical use.
Patent NZ-229162-A (NZ)
Title: Precipitated silica; preparation and compositions thereof
Inventor: PONCHON JEAN-LUC
IPC: C01B33/193
Filed: 1989-05-17
Abstract: The invention relates to an absorbent precipitated silica and to compositions based on a liquid, for example of vitamin type, which is absorbed on this silica. The silica of the invention has the following characteristics:  - BET surface area of at least 170 m<2>/g;  - oil uptake of between 220 and 300 ml/100 g;  - tamped packing density of at least 0.29;  - median particle diameter of between 80 and 150 m; - particle size dispersion index of not more than 0.70.
Patent NZ-246184-A (NZ)
Title: Dentifrice comprising a lanthocin antibacterial agent
Inventor: DOEL GEOFFREY ROYSTON
IPC: A61K/
Filed: 1992-12-17
Abstract: PCT No. PCT/GB92/02348 Sec. 371 Date Jun. 15, 1994 Sec. 102(e) Date Jun. 15, 1994 PCT Filed Dec. 17, 1992 PCT Pub. No. WO93/11738 PCT Pub. Date Jun. 24, 1993A dentifrice formulation provides a composition which contains and antibacterially effective amount of a lanthocin-type bacyeriocin antibacterial agent such as nisin, gramicidin, or tyrothicin and an orally acceptable low anion or anio-free excipient mixture containing a purified surfactant selected from nonionic surfactant, cationic surfactant and amphoteric surfactant so as to avoid anionic surfactant; a low or anion or anion-free abrasive; a nonionic thickening agent; a humectant; and a fluoride ion producing compound.
Patent NZ-254777-A (NZ)
Title: Glycogen which is substantially free of nitrogenous matter; its preparation by boiling animal tissue in aqueous base, precipitating a product with volatile, water mixable solvent and cationic resin purification
Inventor: NICOLETTI ROSARIO
IPC: C08B37/00
Filed: 1993-07-28
Abstract: Glycogen polysaccharides substantially free of nitrogenous compounds and reducing sugars.
Patent NZ-271076-A (NZ)
Title: N-methyl-n-benzyl(or pyrimidinyl)-n'-methyl-n'-(substituted propyl)ethane-1,2-diamine derivatives and pharmaceutical compositions
Inventor: FOQUET RAFAEL
IPC: C07D319/08
Filed: 1994-07-18
Abstract: PCT No. PCT/EP94/02363 Sec. 371 Date Apr. 21, 1995 Sec. 102(e) Date Apr. 21, 1995 PCT Filed Jul. 18, 1994 PCT Pub. No. WO95/03270 PCT Pub. Date Feb. 2, 1995The invention relates to new N,N,N'N'-tetra-substituted-1,2-ethanediamine compounds of the general formula (I):    <IMAGE>  (I)  wherein X is a carbonyl (CO), hydroxymethylen (CHOH) or p-fluorophenyl-methylen (p-F-C6H4-CH) group and R is a benzyl group optionally substituted in p- with an halogen, or R is a 2-pyrimidinyl group with the proviso that simultaneously X may not be p-fluorophenyl-methylen (p-F-C6H4-CH) and R may not be an unsubstituted benzyl group, as well as their pharmaceutically acceptable additions salts. The compounds are potentially useful in the treatment of sigma receptor-related nervous system diseases.
Patent NZ-279958-A (NZ)
Title: Isolation of clavulanic acid from the fermentation broth of streptomyces sp p 6621
Inventor: CAPUDER EGIDIJ
IPC: A61K31/00
Filed: 1995-02-23
Abstract: A process for the isolation of clavulanic acid pharmaceutically acceptable salts thereof, such as potassium clavulanate, from the aqueous fermentation broth of a clavulanic acid-producing microogranism comprises the microfiltration of the broth without prior treatment.
Patent NZ-282973-A (NZ)
Title: Particles comprising compositions of chlorpyrifos or endosulfan microencapsulated by a polyurea and particles also comprising a uv and visible light stable absorbent
Inventor: MARCUS ARIE
IPC: A01N25/28
Filed: 1995-03-03
Abstract: The present invention relates to a microencapsulated chlorpyrifos or endosulfan composition comprising a polyurea shell and one or more photostable ultraviolet and visible light absorbent compound having a log molar extinction coefficient of from about 2 to 5 with respect to radiation having wave lengths in the range of about 310 to 450 nanometers, wherein said photostable ultraviolet and visible light absorbent compound does not react with the monomer used in building the polyurea shell. The result is a microencapsulated composition having unexpected long, extended insecticidal activity with high toxicity to target species and very low toxicity to non-target animals.
Patent NZ-288221-A (NZ)
Title: Synergistic fungicidal mixtures comprising an oxime ether carboxylic acid ester
Inventor: AMMERMANN EBERHARD
IPC: A01N43/653
Filed: 1995-05-27
Abstract: PCT No. PCT/EP95/02025 Sec. 371 Date Dec. 10, 1996 Sec. 102(e) Date Dec. 10, 1996 PCT Filed May 27, 1995 PCT Pub. No. WO95/34203 PCT Pub. Date Dec. 21, 1995A fungicidal mixture containing a) an oxime ether carboxylic acid ester of the formula Ia or Ib    <IMAGE>  Ia   <IMAGE>  Ib  and b) 1-(1,2,4-triazol-1-yl)-2-cyano-2-(4-chlorophenyl)hexane II   <IMAGE>   in a synergistically active amount is described.
Patent NZ-302613-A (NZ)
Title: Open cell polymeric foam with ion exchange sites
Inventor: JAY WILLIAM HAROLD
IPC: B01J41/13
Filed: 1996-03-12
Abstract: his process is for the selective removal of ions from dispersion of solids in solutions and also relates to coarse open cell polymeric foams which support ion exchange sites.  The process for the selective removal of ions from a solution having solid materials dispersed therein comprises passing the solution having solid materials dispersed therein through a bed of coarse open cell polymeric foam having ion exchange sites.  The ion-selective coarse open cell polymeric foam has a cell size sufficient to allow solutions having solids dispersed therein to pass through the foam.
Patent NZ-309065-A (NZ)
Title: (2-morpholinymethyl)benzamide derivatives having gastrointestinal motility stimulating properties
Inventor: VAN DAELE GEORGES HENRI PAUL
IPC: A61K31/5375
Filed: 1996-05-15
Abstract: The present invention concerns novel (2-morpholinylmethyl)benzamide derivatives having the formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein R1 is C1-6alkyl, C2-6alkenyl or C2-6alkynyl; R2 is hydrogen, halo or C1-6alkylsulfonylamino; R3 is hydrogen or C1-6alkyl; L is a radical of formula R4-C(=O)-Alk- (a); R5-C(=O)-N(R6)-Alk- (b); or R7-C(=O)-O-Alk- (c); wherein each Alk is independently C1-12alkanediyl; R4 is hydrogen, hydroxy, C1-6alkyl, C1-6alkyloxy, amino, mono- or di(C1-6alkyl)amino or an optionally substituted heterocyclic ring; R5 and R7 each independently are hydrogen, C1-6alkyl, C1-6alkyloxy, amino, mono- or di(C1-6alkyl)amino or an optionally substituted heterocyclic ring; R6 is hydrogen or C1-6alkyl; and aryl is phenyl or phenyl substituted with 1, 2 or 3 substituents selected from halo, C1-6alkyl or C1-6alkyloxy. It further relates to pharmaceutical compositions comprising them, processes for preparing said compounds and compositions, and the use thereof as a medicine, in particular in the conditions involving a decreased gastric emptying.
Patent NZ-330136-A (NZ)
Title: Stable liquid paracetamol compositions comprising polyhydric or water soluble alcanol and buffering agent, and further containing a free radical antagonist or scavenger
Inventor: DIETLIN FRANCOIS
IPC: A61K31/485
Filed: 1997-08-05
Abstract: Paracetamol based stable liquid formulations in an aqueous solvent, wherein the aqueous solvent is a mixture containing water and a polyhydric compound selected from an aliphatic polyhydric alcohol with 2-10 carbon atoms, or a water soluble alcanol and a buffering agent and the formulations further comprising at least one free radical antagonist or one free radical scavenger selected from ascorbic acid derivatives, organic compounds bearing at least one thiol functional group and polyhydric compounds. This compound may further comprise isotonizing agent, an analgesic, an anti-inflammatory, antiemetic, antiepileptic, corticosteroid, and tricyclic antidepressant.
Patent NZ-330867-A (NZ)
Title: High performance liquid chromatography (hplc) method and apparatus
Inventor: QUINN HUBERT M
IPC: B01D15/16
Filed: 1997-01-21
Abstract: High pressure liquid chromatographic apparatus in which a fluid mixture containing at least one solute that is reactive with chromatographically reactive surfaces in the column is loaded into the column, and a number of plugs of different eluant fluids are injected into that column. The injections are made in a manner that minimizes the amount of eluant required. In one embodiment, the injections are made to insure that flow of at least the eluant fluids through the column will occur, preferably with a substantially flat wave front, at speeds corresponding to reduced velocities greater than about 5,000, i.e. at flow rates sufficient to induce turbulent flow in those fluids, thereby minimizing the time required for the entire succession of mixture and eluant fluids to traverse the column. In other embodiments, the injections are made substantially simultaneously at spatially separated points adjacent the entrance to the column or are made in sequence to a single location adjacent the entrance to the column, in either case the fluids then tend to travel through the column at a common group velocity as closely bunched fluid plugs.
Patent NZ-335063-A (NZ)
Title: Immediate wettability water soluble film or water soluble layer for oral application
Inventor: SERINO ANTHONY J
IPC: A61P11/00
Filed: 1997-10-22
Abstract: A film composition containing therapeutic agents and/or breath freshening agents for use in the oral cavity. The carrier comprises at least one water-soluble polymer, a polyalcohol, an optional plasticiser and/or surfactant. The film is coated and dried utilizing existing coating technology and exhibits instant wettability followed by rapid dissolution/disintegration upon administration in the oral cavity.
Patent NZ-335396-A (NZ)
Title: Methods and compositions for stimulating neurite growth using compounds with affinity for fkbp12 in combination with neurotrophic factors
Inventor: ZELLE ROBERT E
IPC: A61P25/28
Filed: 1997-11-13
Abstract: The application relates to methods and pharmaceutical compositions for stimulating the growth of neurites in nerve cells. The compositions comprise (a)	a neurotrophic amount of a compound of Formula (I) where: A is CH2, O or NR1; R1, B and D are selected from hydrogen, and optionally substituted aryl, cycloalkenyl, alkyl, and alkenyl; J is H, alkyl, alkenyl or CH2aryl and K is alkyl, CH2aryl or cyclohexyl; or J and K form a 5-7 membered ring optionally containing O, S, SO, SO2; Z is O or S; Y is O or N and (b)	a neurotrophic factor, such as nerve growth factor (NGF). The methods comprise treating nerve cells with the above compositions or compositions comprising the compound without a neurotrophic factor. The methods of this invention can be used to promote repair of neuronal damage caused by disease or physical trauma.