Patent GB-490001-A (GB)
Title: Improvements in or relating to a vitamin product
IPC: A61K31/16
Filed: 1937-01-30
Abstract: A solid stable vitamin-containing product in the form of granules of very small size is prepared by dispersing an emulsion of a vitamin-bearing oil in aqueous gelatine or like colloid solution, such as is described in Specification 489,970, in an immiscible liquid, so that the initial emulsion forms the internal phase of the final polyphase emulsion, cooling to cause the colloid to set to a jelly, drying to remove part of the water from the colloid particles and removing the immiscible liquid therefrom.  The colloid, such as gelatine, is adjusted to the iso-electric point or may be rendered more alkaline, for instance, up to pH = 9, and may contain a plasticizer such as glycerine or glucose.  In one embodiment, fish liver oil, or a concentrate thereof, containing vitamins A or D or both, is emulsified in gelatine or pectin solution, which may contain other colloids and a reducing substance such as SO2 or a sulphite, and this emulsion is dispersed in an immiscible liquid such as cottonseed oil, coconut oil or mineral oil so as to form globules of a diameter from 0,01 to 1,0 mm.  The oil used as the external phase may contain a little linseed oil or polar compounds, such as fatty acids, calcium or magnesium soaps, other oil-soluble colloids, or sterols.  The mass is then poured on to a belt or other support of glass, metal or rubber so as to form a film of about 3/32 inch thickness and is cooled to cause the droplets of gelatine to set to a jelly.  The film is then broken up by gentle rubbing and, preferably after removal of part only of the external oil phase, is dried in a current of warm air.  The remaining oil is removed by means of a solvent, the solvent removed by evaporation, and the beads of gelatine, containing vitamin-bearing oil dispersed therein are graded into sizes, if desired after further drying.  The small particles thus produced may be used for addition to cereal poultry food, may be compressed into tablets with or without medicaments and with or without sugar coatings, or may be incorporated into dried milk, malted milk powder, or chocolate preparations.  Specification 15365/15, [Class 49], is referred to.ALSO:A solid vitamin-containing product in the form of granules of very small size is prepared by dispersing an emulsion of a vitamin-bearing oil in aqueous gelatin or like colloid solution, such as is described in Specification 489,970, in an immiscible liquid, so that the initial emulsion forms the internal phase of the final polyphase emulsion, cooling to cause the colloid to set to a jelly, drying to remove part of the water from the colloid particles and removing the immiscible liquid therefrom. The colloid such as gelatin, is adjusted to the iso-electric point or may be rendered more alkaline for instance up to pH = 9 and may contain a plasticizer such as glycerine or glucose.  In one embodiment fish liver oil, or a concentrate thereof, containing vitamins A or D or both, is emulsified in gelatin or pectin solution, which may contain other colloids and a reducing substance such as SO2 or a sulphite, and this emulsion is dispersed in an immiscible liquid such as cottonseed oil, coconut oil or mineral oil so as to form globules of a diameter from 0,01 to 1,0 mm.  The oil used as the external phase may contain a little linseed oil or polar compounds, such as fatty acids, calcium or magnesium soaps, other oil-soluble colloids, or sterols.  The mass is then poured on to a belt or other support of glass, metal, or rubber so as to form a film of about 3/32 inch thickness and is cooled to cause the droplets of gelatin to set to a jelly.  The film is then broken up by gentle rubbing and, preferably after removal of part only of the external oil phase, is dried in a current of warm air.  The remaining oil is removed by means of a solvent, the solvent removed by evaporation, and the beads of gelatin containing vitamin-bearing oil dispersed therein are graded into sizes, if desired after further drying.  The small particles thus produced may be used for addition to cereal poultry food, may be compressed into tablets with or without medicaments and with or without sugar coatings, or may be incorporated into dried milk, malted milk powder, or chocolate preparations. Specification 15365/15, [Class 49], is referred to.ALSO:A solid vitamin-containing product, in the form of granules of very small size for addition to cereal poultry food, is prepared by dispersing an emulsion of a vitamin-bearing oil in aqueous gelatine or like colloid solution, such as is described in Specification 489,970, in an immiscible liquid, so that the initial emulsion forms the internal phase of the final polyphase emulsion, cooling to cause the colloid to set to a jelly, drying to remove part of the water from the colloid particles and removing the immiscible liquid therefrom.  The colloid, such as gelatine, is adjusted to the iso-electric point or may be rendered more alkaline, for instance up to pH 9, and may contain a plasticizer such as glycerine or glucose.  In one embodiment, fish liver oil, or a concentrate thereof, containing vitamins A or D or both, is emulsified in gelatine or pectin solution, which may contain other colloids and a reducing substance such as SO2 or a sulphite, and this emulsion is dispersed in an immiscible liquid such as cottonseed oil, coconut oil or mineral oil so as to form globules of a diameter from 0,01 to 1,0 mm.  The oil used as the external phase may contain a little linseed oil or polar compounds, such as fatty acids, calcium or magnesium soaps, other oil-soluble colloids, or sterols.  The mass is then poured on to a belt or other support of glass, metal or rubber so as to form a film of about 3/32 inch thickness and is cooled to cause the droplets of gelatine to set to a jelly.  The film is then broken up by gentle rubbing and, preferably after removal of part only of the external oil phase, is dried in a current of warm air.  The remaining oil is removed by means of a solvent, the solvent removed by evaporation, and the beads of gelatine, containing vitamin-bearing oil dispersed therein are graded into sizes, if desired after further drying.  Specification 15365/15, [Class 121], is referred to.