Patent SG-11201901597U-A (SG)
Title: Macrophage stimulating protein receptor (or ron - recepteur d' origine nantais) antibodies and uses thereof
Inventor: LANE DAVID
IPC: G01N33/53
Filed: 2017-08-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 March 2018 (01.03.2018) W I PO I PCT olimion °nolo III 01110l mnio oimIE (10) International Publication Number WO 2018/038684 Al (51) International Patent Classification: C07K 16/30 (2006.01) A61P 35/00 (2006.01) A61K 39/395 (2006.01) G01N 33/53 (2006.01) (21) International Application Number: PCT/SG2017/050424 (22) International Filing Date: 28 August 2017 (28.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201607147P 26 August 2016 (26.08.2016) SG 10201700393P 17 January 2017 (17.01.2017) SG 10201700521V 20 January 2017 (20.01.2017) SG 10201703234U 19 April 2017 (19.04.2017) SG (71) Applicant: AGENCY FOR SCIENCE, TECHNOLO- GY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10 Connexis North Tower, Singapore 138632 (SG). (72) Inventors: LANE, David; c/o p53 Laboratory, 8A Bio- medical Grove, #06-04/05 Neuros, Singapore 138646 (SG). KOH, Xin Yu; c/o p53 Laboratory, 8A Biomedical Grove, #06-04/05 Neuros, Singapore 138646 (SG). HWANG, Le- Ann; c/o p53 Laboratory,8A Biomedical Grove, #06-04/05 Neuros, Singapore 138646 (SG). (74) Agent: SPRUSON & FERGUSON (ASIA) PTE LTD; P.O. Box 1531, Robinson Road Post Office, Singapore 903031 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, = (54) Title: MACROPHAGE STIMULATING PROTEIN RECEPTOR (OR RON - RECEPTEUR D' ORIGINE NANTAIS) ANTI- BODIES AND USES THEREOF FIGURE 4 a A PSI IPT domain 768 1-1 71' 60 RON 5 RQNHO ellp (57) : Disclosed are monoclonal antibodies that bind specifically to macrophage stimulating protein receptor (or RON - Re- O 00 1-1 cepteur d' Origine Nantais). Also provided are the chimeric antigen receptors, bispecific antibodies, bivalent antibodies and biTE there- of, as well as pharmaceutical compositions and uses of said antibodies for the treatment of cancer and fibrosis and an ex vivo method of evaluating the status of a cancer patient using said antibodies. In particular, two monoclonal antibodies, 7G8 and 6D4, demonstrating O good therapeutic efficacy in inhibiting tumour growth in human xenograft mice models and sensitivity in human xenograft mouse N tumour imaging models are provided. C [Continued on next page] WO 2018/038684 Al MIDEDIMOMOIDEIREIHNIMIOMMIIIIIIIIIIIMEM111111111 KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))