Patent SG-11201807694W-A (SG)
Title: Methods and systems for assessing infertility and ovulatory function disorders
Inventor: BEIM PIRAYE
IPC: G01N33/53
Filed: 2017-03-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization MINII111011101 01011111 010 11111 01110111 11111 11111 010 111110 11111111111 00 1111 International Bureau 0.. .... .. ...... ... (10) International Publication Number (43) International Publication Date WO 2017/156279 A3 14 September 2017 (14.09.2017) WIP0 I PCT (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, C12Q 1/68 (2006.01) G01N 33/50 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, G01N 33/53 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (21) International Application Number: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, PCT/US2017/021583 MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (22) International Filing Date: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 9 March 2017 (09.03.2017) RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (25) Filing Language: English ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, 62/306,027 9 March 2016 (09.03.2016) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: CELMATIX INC. [US/US]; 14 Wall St, Suite TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 16d, New York, NY 10005 (US). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors: BEIM, Piraye, Yurttas; 70 Little West Street, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Phlb, New York, NY 10004 (US). PARFITT, David, GW, KM, ML, MR, NE, SN, TD, TG). Emlyn; 54 West 40th Street, New York, NY 10018 (US). HU-SELIGER, Tina; 146 East 49th Street, Apartment 5b, Published: New York, NY 10017 (US). SANTISTEVAN, Anthony; with international search report (Art. 21(3)) = 3505 Broadway, Apartment 36, New York, NY 10031 before limit (US). — the expiration of the time for amending the be in claims and to republished the event of receipt of = (74) Agents: MEYERS, Thomas, C. et al.; Brown Rudnick amendments (Rule 48.2(h)) LLP, One Financial Center, Boston, MA 02111 (US). (88) Date of publication of the international search report: (81) Designated States (unless otherwise indicated, for every 19 October 2017 kind of national protection available): AE, AG, AL, AM, = = = = = = = = = M C:7 IN ei ,tD in (54) Title: METHODS AND SYSTEMS FOR ASSESSING INFERTILITY AND OVULATORY FUNCTION DISORDERS Il ---.. (57) : The present invention relates to methods and systems for assessing risk of infertility and ovarian dysfunction and/or diminished ovarian reserve and/or for determining an appropriate course of treatment. In some embodiments, the invention provides Il C methods for assessing likelihood of ovarian dysfunction, including identifying a plurality of genetic variants that are filtered into N functional biological pathways. The frequency distribution of the variants in each functional pathway is then compared to frequency 0 distributions obtained from reference sets corresponding to each pathway. Further embodiments of the invention comprise clustering subjects based on patterns in their genetic variants, and identifying phenotypic differences with respect to ovarian dysfunction between clusters of patients.