baber/WOPTO huggingface dataset:
Patent AU-771626-B2 (AU)
Title: 2-amino-nicotinamide derivatives and their use as VEGF-receptor tyrosine kinase inhibitors
Inventor: MANLEY PAUL WILLIAM
IPC: A61P17/00
Filed: 2001-01-25
Granted: 2004-04-01
Abstract: The invention relates to the use of 2-amino-nicotinamide derivatives of formula I   
wherein n is from 1 up to and including 6; 
W is O or S; 
R 1  and R 3  represent independently of each other hydrogen, lower alkyl or lower acyl; 
R 2  represents a cycloalkyl group, an aryl group, or a mono- or bicyclic heteroaryl group comprising one or more ring nitrogen atoms and 0, 1 or 2 heteroatoms independently from each other selected from the group consisting of oxygen and sulfur, which groups in each case are unsubstituted or mono- or polysubstituted; 
R and R' are independently of each other hydrogen or lower alkyl; 
X represents an aryl group, or a mono- or bicyclic heteroaryl group comprising one or more ring nitrogen atoms and 0, 1 or 2 heteroatoms independently from each other selected from the group consisting of oxygen and sulfur, which groups in each case are unsubstituted or mono- or polysubstituted; 
or a N-oxide, a possible tautomer thereof or a pharmaceutically acceptable salt of such a compound, 
alone or in combination with one or more other pharmaceutically active compounds for the preparation of a pharmaceutical composition for use for therapy of a disease which responds to an inhibition of the VEGF-receptor tyrosine kinase activity; 
and to new 2-amino-nicotinamide derivatives of formula I and processes for the preparation thereof.
Patent AU-752515-B2 (AU)
Title: Polyolefin nanocomposites
Inventor: ALEXANDRE MICHAEL
IPC: C08K3/34
Filed: 1999-03-16
Granted: 2002-09-19
Abstract: The present invention is a nanocomposite which is a dispersion of nanofiller particles derived from layered metal oxides or metal oxide salts. The nanocomposite is advantageously prepared by first swelling an untreated clay in water, then removing the water to form an organophilic clay that is dispersible in non-polar organic solvents. The organophilic clay can then be treated with an alkyl aluminoxane and subsequently a catalyst to form a complex that promotes olefin or styrenic polymerization and platelet dispersion. The nanocomposite can be prepared directly by in situ polymerization of the olefin or the styrene at the nanofiller particles without shear, without an ion exchange step, and without the need to incorporate polar substituents into the polyolefin or polystyrene.
Patent AU-688077-B2 (AU)
Title: Mechanism for endoscopic suturing device
Inventor: STONE CORBETT W
IPC: A61B17/06
Filed: 1995-08-17
Granted: 1998-03-05
Abstract: The loading unit is for supplying multiple surgical needles or surgical incision members and associated lengths of suture material for positioning the needle or surgical incision member within the jaws of a surgical suturing apparatus. The unit includes a body portion having device receiving structure for receipt of the surgical suturing device and a carousel rotatably affixed to the body portion and containing a supply stations on it. The supply stations include a support member for supporting a central portion of a surgical needle and a storage member for temporarily securing a length of suture material associated with the surgical needle. The device receiving structure includes structure for aligning and maintaining the surgical suturing device in position on the loading unit until such time as a surgical incision member has been inserted into jaws associated with the surgical suturing device. Preferably, the device receiving structure includes structure for gasping an elongate portion of the surgical suturing device and structure for supporting jaw members associated with the surgical suturing device. Additionally, in a preferred embodiment, the suture storage members consist of a suture reel which is positioned in a plane offset from the needle support members.
Patent AU-714129-B2 (AU)
Title: Combination preparation, containing cyclosporin A or FK506 or rapamycin and a xanthine derivative
Inventor: SCHONHARTING MARTIN
IPC: A61K38/13
Filed: 1995-08-07
Granted: 1999-12-16
Abstract: Xanthines of the formula Iare useful in producing a superadditive increase in immunosuppressive action when combined with immunosuppressive compounds such as CysA or FK506.
Patent AU-772168-B2 (AU)
Title: Timed pulsatile drug delivery systems
Inventor: PERCEL PHILLIP J
IPC: A61K9/40
Filed: 2001-02-08
Granted: 2004-04-08
Abstract: A pharmaceutical dosage form such as a capsule capable of delivering therapeutic agents into the body in a time-controlled or position-controlled pulsatile release fashion, is composed of a multitude of multicoated particulates (beads, pellets, granules, etc.) made of one or more populations of beads. Each of these beads except an immediate release bead has at least two coated membrane barriers. One of the membrane barriers is composed of an enteric polymer while the second membrane barrier is composed of a mixture of water insoluble polymer and an enteric polymer. The composition and the thickness of the polymeric membrane barriers determine the lag time and duration of drug release from each of the bead populations. Optionally, an organic acid containing intermediate membrane may be applied for further modifying the lag time and/or the duration of drug release. The pulsatile delivery may comprise one or more pulses to provide a plasma concentration-time profile for a therapeutic agent, predicted based on both its pharmaco-kinetic and pharmaco-dynamic considerations and in vitro/in vivo correlations.
Patent AU-609301-B2 (AU)
Title: Process for the determination of an immunologically detectable substance and a suitable reaction vessel therefor
Inventor: SCHMITT URBAN
IPC: G01N33/543
Filed: 1989-05-24
Granted: 1991-04-26
Abstract: To determine an immunologically detectable substance on the principle of the heterogeneous immunoassay using a solid phase to which one of the immunologically active reactants is bound, the solid phase used is a reaction vessel to whose inner surface streptavidin or avidin is bound in an amount such that 0.1 to 2.5  mu g are present per ml of reaction volume. A reaction vessel suitable for this purpose has opposite optically transparent wall regions and, moreover, is coated, at least partially in the region of the inner wall provided to receive liquid, with streptavidin or avidin, where the interior of the container intended to receive liquid, and the streptavidin or avidin content of the coating are matched with one another so that 0.1 to 2.5  mu g of streptavidin or avidin are present per ml of reaction volume. <IMAGE>
Patent AU-665239-B2 (AU)
Title: Self-locking safety syringe
Inventor: MARTIN ROBIN P
IPC: A61M5/315
Filed: 1993-01-11
Granted: 1995-12-21
Abstract: The invention relates to a safety syringe to prevent accidental puncturing of attending medical personnel by an infected syringe needle. The safety syringe has an elongated tubular casing, which houses an elongated needle guard, which is telescopically connected to the casing and is mounted in co-axial alignment with the casing. A syringe barrel is co-axially mounted within the needle guard, the syringe barrel carrying a needle assembly on one of its ends, and an end plate on its opposite end. The end plate "snaps" into a groove formed in a transverse flange of the casing, fixedly attaching the syringe barrel to the casing. A sealing plate covers the locked end plate by engaging within another groove formed in the flange. One or more resilient depressible locking tabs are carried by the needle guard and extend through corresponding aligned openings formed in the casing to lock the needle guard in an extended position covering the needle. When the locking tabs are depressed, and an inward pressure is exerted on the forward end of the needle guard, the needle guard can be moved against the tension of a coil spring inside the casing and uncover the syringe needle to allow withdrawing of medication from the medicine bottle, or performing of an injection.
Patent AU-637574-B2 (AU)
Title: Pyrimidine nucleosides and intermediates
Inventor: JOHANSSON K NILS GUNNAR
IPC: A61K31/7052
Filed: 1989-06-07
Granted: 1993-06-03
Abstract: Compounds of the formula <CHEM> wherein R<1> is OH, NH2; R<2> is a heteroaromatic or aromatic substituent as defined in claim 1; R<3> is H, OH, F, OCH3; R<4> is H, F, OH or an ether or ester residue thereof, OCH3, CN, C IDENTICAL CH, N3; R<5> is OH or an ether or ester residue thereof including mono-, di- and triphosphate esters; <CHEM> wherein n is O or 1 and M is hydrogen or a pharmaceutically acceptable counterion such as sodium, potassium, ammonium or alkylammonium; and pharmaceutically acceptable salts thereof; and pharmaceutical compositions comprising said compounds can be used for therapeutic and/or prophylactic treatment of virus infections such as AIDS. Compounds of the formula <CHEM> wherein R<1> and R<2> are as defined above, are new precursor compounds.
Patent AU-564865-B2 (AU)
Title: Pharmaceutical composition of aqueous sodium bicarbonate and sodium carbonate
Inventor: FILLEY GILES F
IPC: A61K33/00
Filed: 1985-01-18
Granted: 1987-08-27
Abstract: A parenterally administrable solution for use in treating mammalian acidosis comprises sodium carbonate and sodium bicarbonate in a pharmaceutically acceptable diluent.
Patent AU-668170-B2 (AU)
Title: Calcium channel blocking polypeptides from filistata hibernalis
Inventor: NASON DEANE M II
IPC: A61P9/00
Filed: 1993-04-30
Granted: 1996-04-26
Abstract: PCT No. PCT/US93/03921 Sec. 371 Date May 3, 1995 Sec. 102(e) Date May 3, 1995 PCT Filed Apr. 30, 1993 PCT Pub. No. WO93/23428 PCT Pub. Date Nov. 25, 1993Polypeptides isolated from the venom of the Filistata hibernalis spider block calcium channels in cells of various organisms and are useful in blocking said calcium channels in cells, per se, in the treatment of calcium channel-mediated diseases and conditions and in the control of invertebrate pests.
Patent AU-757678-B2 (AU)
Title: Addition polymerisation
Inventor: IRVINE DEREK JOHN
IPC: C08F/
Filed: 1999-06-09
Granted: 2003-02-27
Abstract: A method of producing a polymer comprises the steps of forming a heterogeneous reaction mixture comprising at least one addition polymerizable monomer, a supercritical fluid, and a stabilizer, wherein the stabilizer comprises a chain which is soluble in the supercritical fluid and functional end-group which is not polymerizable by a free-radical mechanism, and polymerizing said at least one monomer in the reaction mixture. In a preferred system for polymerizing acrylic monomers, the fluid comprises supercritical carbon dioxide and the stabilizer comprises an acid-functionalized perfluoropolyether.
Patent AU-748026-B2 (AU)
Title: Polymorphic modifications of 2-(3-cyano-4-isobutyloxyphenyl)- 4-methyl-5-thiazole-carboxylic acid and processes for the preparation thereof
Inventor: MATSUMOTO KOICHI
IPC: C07D277/56
Filed: 1999-06-18
Granted: 2002-05-30
Abstract: The present invention provides a technique of selectively producing a desired polymorph of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid.  The present invention also provides a method of producing various polymorphs of 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid, which comprises crystallizing under the conditions defined by a specific temperature and a composition of a mixed solvent of methanol and water, and polymorphs obtained by the method.  The present invention further provides a method of producing the other polymorphs or amorphous compounds by drying a specific polymorph under a reduced pressure with heating, and the other polymorphs or amorphous compounds obtained by the method.
Patent AU-759989-B2 (AU)
Title: Transcoders for fixed and variable rate data streams
Inventor: CRAVEN PETER GRAHAM
IPC: G10L19/02
Filed: 1999-07-05
Granted: 2003-05-01
Abstract: A transcoder is provided for receiving encoded data read from a Digital Video Disc. This data usually comprises variable length audio data packets, each data packet including a packet header. For the invention, at least one packet header for each track gives the peak data rate of the track. The transcoder converts the variable rate packetised stream into a fixed rate stream of the same rate as the peak rate indicated in the packet header. This fixed rate stream is suitable for transmission over certain interface protocols, or else for storage on a storage medium if fixed rate stored audio is desired. The track may give data indicating the minimum rate to which the data could be reserialised, or repacketised, for controlling the operation of a subsequent transcoder.
Patent AU-750670-B2 (AU)
Title: Anthranilic acid derivatives
Inventor: TSUCHIYA NAOKI
IPC: C07C235/38
Filed: 1999-07-23
Granted: 2002-07-25
Abstract: The present invention relates to an anthranilic acid derivative expressed by the following formula (1) or the following formula (2), or its pharmacologically permissible salt or solvate. <CHEM>
Patent AU-643672-B2 (AU)
Title: Process for the introduction of exogenous DNA in somatic and germ animal cells
Inventor: SPADAFORA CORRADO
IPC: C12N15/87
Filed: 1990-01-08
Granted: 1993-11-25
Abstract: A process is described for the introduction of exogenous DNA into somatic and germ animal cells: the DNA, exogenous or modified according to known techniques of recombinant DNA, is introduced into the animal spermatozoa which are to be modified and said spermatozoa are employed for egg fertilization according to usual artificial fertilization techniques.
Patent AU-642639-B2 (AU)
Title: Solar concentrator arrangement
Inventor: LECHNER RUDOLF
IPC: F24S23/70
Filed: 1990-02-21
Granted: 1993-10-28
Abstract: PCT No. PCT/DE90/00118 Sec. 371 Date Aug. 22, 1991 Sec. 102(e) Date Aug. 22, 1991 PCT Filed Feb. 21, 1990 PCT Pub. No. WO90/10182 PCT Pub. Date Sep. 7, 1990.The solar concentrator arrangement has a concentrating mirror (2) consisting of a metallised plastic shell to reflect parallel incident light. The concentrating mirror ( 2 ) forms part of a foil tube (1) and co-operates with a secondary concentrator (5) which deflects the parallel incident light beams (3,4) from the concentrating mirror concentrically on a heat exchanger. The heat exchanger (7) is placed on the focal line of the secondary concentrator (5) are rigidly secured together and can be automatically moved in relation to the heat exchanger (7) according to the position of the sun.
Patent AU-767915-B2 (AU)
Title: Apparatus for positioning a symbol display device at a coin operated entertainment machine
Inventor: GAUSELMANN MICHAEL
IPC: G07F17/32
Filed: 2000-08-07
Granted: 2003-11-27
Abstract: The device positions the symbol display device (5) so as to be able to move vertically on the door element (4) of the housing of the games machine (1). The symbol display device can be moved by a control drive actuated by an auxiliary force. The symbol display device can be pivoted away from the vertical on a vertically movable holder and can contain two flat screens.
Patent AU-664784-B2 (AU)
Title: Clamp
Inventor: KRONAUER KARLHANS
IPC: D06F57/00
Filed: 1993-12-17
Granted: 1995-11-30
Abstract: PCT No. PCT/EP94/00099 Sec. 371 Date Sep. 13, 1994 Sec. 102(e) Date Sep. 13, 1994 PCT Filed Jan. 14, 1994 PCT Pub. No. WO94/15506 PCT Pub. Date Jul. 21, 1994A clamp for arrangement on a carrying arm is described. The clamp has a first and a second clamp half (10, 20) with in each case two lateral angle pieces (12; 21 ), in which are located a hole (14; 23) for positioning the clamp halves (10, 20) on the carrying arm, whereby the angle pieces (12, 21) which are directed against each other lie pairwise against each other and in each case one angle piece (21) of each clamp half (10, 20) lies on the inside and the other angle piece (12) of the same clamp half (10, 20) lies on the outside, and a legged spring (4) which lies between the clamp halves (10, 20) and keeps the clamps (3) closed. The internal angle piece (21) of one clamp half (10; 20) interlocks rotatably with the external angle piece (12) of the other clamp half (20; 10), and the legged spring (4) fills, in axial direction, the space between the internal angle pieces (21) in each case of the clamp halves (10, 20).
Patent AU-638984-B2 (AU)
Title: Chassis for a motorcycle
IPC: B62K25/24
Filed: 1990-04-12
Granted: 1993-07-15
Abstract: In a frame for a motorcycle, comprising a frame (10) with means for holding a rear wheel, a single-armed rocker (20) which is coupled in the front lower area of the frame (10) so as to be swivellable on the frame (10) about a swivel axis parallel to the rear wheel axis and is connected near to its free front end to a hub support for bearing a front wheel (26), a steering device having a connecting link support (14) mounted swivellably on the frame (10) and having gimbal linkages (28) having at least two joint axes perpendicular to one another and to the swivel axis (16) of the connecting link support (14) and a suspension and damping device (118), arranged between the rocker (20) and the frame (10), in order to damp the rocking movement, the hub support is mounted on an axle stub (32) which is connected to the rocker (20) so as to be swivellable about a swivel axis directed perpendicularly with respect to the latter, located, at right angles to the axle, in the central plane of the front wheel (26) and running through its axle. 
<IMAGE>
Patent AU-626409-B2 (AU)
Title: 1,2,3-triazolo(4,5-c) pyridine derivatives
Inventor: KELLEY JAMES LEROY
IPC: A61P25/00
Filed: 1990-04-20
Granted: 1992-07-30
Abstract: There is disclosed a series of triazolopyrimidine compounds and pharmaceutical compositions containing them. The disclosed compounds are useful in the treatment of central nervous disorders, such as epilepsy, in mammals. Methods for the preparation of these triazolopyrimidines are also disclosed.
Patent AU-667598-B2 (AU)
Title: Storage rack
Inventor: MULLER FRANK
IPC: G11B23/023
Filed: 1994-01-20
Granted: 1996-03-28
Abstract: A rack for the storage of CD cases or other rectilinear objects preferably has a support providing two lateral wall components that hold or support the CD cases at least in the area of one of their diagonal ends by means of opposite, lateral contacts, whereby the lateral wall components that face the CD cases are arranged at an angle of greater than 90 DEG  relative to each other, thereby forming an imaginary trapezoidal area. Cross supports are arranged between the lateral wall components for the purpose of forming compartments for the CD cases, said cross supports preferably being arranged as rod-shaped elements that are positioned with slight clearance within the vicinity of the diagonal lines of the CD cases, which are inserted diagonally between the lateral wall components in the direction of the apex of the angle.
Patent AU-579010-B2 (AU)
Title: Device for controlled evaporation
Inventor: JOYAUX YVES
IPC: B65D47/26
Filed: 1986-04-09
Granted: 1988-11-10
Abstract: A device for permitting controlled emission of a volatile substance, in particular an air-treating agent. The device comprises a container having an annular ledge with two recesses on opposite sides and a frustro hemispherical hood open at the top, that fits on to the container. The hood has two studs protruding on opposite sides of its inner wall. Inside the hood are situated two shutters that are moveable in relation to each other on relative rotation between the container and the hood by means of slots, which are moved by the studs, to close or open the opening to an infinitely variable degree.
Patent AU-656515-B2 (AU)
Title: Mixed fiber composite structures: method of preparation, articles therefrom, and uses therefor
Inventor: TATARCHUK BRUCE J
IPC: D04H1/42
Filed: 1990-05-24
Granted: 1995-02-09
Abstract: A new class of composites results from a matrix of fibers, such as fibers of carbon, alumina, ceramics, and aluminosilicates, interwined in a network of fused metal fibers. The composites can be fabricated to have varying surface area, void volume, and pore size while maintaining high electrical conductivity. Composites are readily prepared from a preform of a dispersion of the metal fibers, other fibers, and an organic binder such as cellulose, by heating the preform at a temperature sufficient to fuse the metal fibers and to volatilize at least 90% of the binder. Where a carbon fiber is used, the metal fibers are fused at a temperature causing a loss of less than about 25%, and usually under 15%, by weight of carbon fiber.
Patent AU-705261-B2 (AU)
Title: Methods of combatting infectious diseases using dicationic bis-benzimidazoles
Inventor: DYKSTRA CHRISTINE C
IPC: A61K31/4439
Filed: 1996-06-03
Granted: 1999-05-20
Abstract: The present invention provides methods for treating Crytococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
Patent AU-679968-B2 (AU)
Title: Abrasive article, method of manufacture of same, method of using same for finishing, and a production tool
Inventor: HOOPMAN TIMOTHY L
IPC: B24D18/00
Filed: 1994-01-21
Granted: 1997-07-17
Abstract: The present invention provides a master tool and method for making a master tool. The master tool includes a plurality of precise three-dimensional shapes upraised from the surface of the master tool. Each of the precise shapes is defined by a distinct and discernible boundary including specific dimensions, wherein not all said three-dimensional shapes are identical. The master tool of the present invention can be used to form a production tool containing a plurality of precise three-dimensional-shaped cavities. The production tool can be used in the manufacture of abrasive articles to shape an abrasive slurry into an array of precise three dimensional-shaped abrasive composites.
Patent AU-734027-B2 (AU)
Title: System and method for controlling the start up of a patient ventilator
Inventor: WALLACE CHARLES L
IPC: A61M16/00
Filed: 1998-02-24
Granted: 2001-05-31
Abstract: A patient ventilator system including an alarm, the system comprising:  a processor (30) connected with a memory (35), the memory for storing values of ventilator operating parameters and values of alarm thresholds; a display (50) connected to the processor for displaying ventilator operating parameters, patient data and alarm threshold data; and entry means (25) connected to the processor for selecting values of ventilator operating parameters from among a plurality of values of a plurality of ventilator operating parameters, as well as said values of alarm thresholds, wherein the processor enters an alarm condition when values of said patient data exceed said alarm thresholds; wherein in an alarm condition, the display (50) shows an analysis message (606) which gives the root cause of an alarm and which describes any dependent alarm that arises due to said root cause.  <IMAGE>
Patent AU-631931-B2 (AU)
Title: Knee-orthesis appliance
IPC: A61F5/01
Filed: 1990-09-27
Granted: 1992-12-10
Abstract: PCT No. PCT/CH90/00229 Sec. 371 Date Jun. 20, 1991 Sec. 102(e) Date Jun. 20, 1991 PCT Filed Sep. 27, 1990 PCT Pub. No. WO91/04721 PCT Pub. Date Apr. 18, 1991.The knee orthesis appliance is made of carbon-fiber composite material with an integral Menshik linkover four bar chain (21) made of titanium. It provides the knee joint with secure and reliable support. Owing to its low weight, it is extremely comfortable to wear. The angle of bend (22) can be adjusted to suit the individual as prescribed by the doctor. The shells of the appliance are made from a positive plaster cast (1), using vacuum composite production techniques. This simple process enables the appliance to be manufactured to a high standard of quality in orthopaedic workshops. The joint plates (5,6) are inserted between the individual layers of the composite. Following filling and curing, the sidepieces (16,17) only have to be riveted to the joint plates to complete the four bar chains and hence the finished appliance.