Patent SG-11201808842V-A (SG)
Title: Heteroaryl substituted pyridines and methods of use
Inventor: ALTENBACH ROBERT J
IPC: C07D417/14
Filed: 2017-05-24
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101/110 111010101111101011111 0 0111111111111111111111111111111111011111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2017/208115 Al 07 December 2017 (07.12.2017) WIP0 I PCT (51) International Patent Classification: MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, C07D 413/14 (2006.01) C07D 417/14 (2006.01) PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, CO7D 413/04 (2006.01) A61K 31/4439 (2006.01) SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, CO7D 417/04 (2006.01) A61P 11/00 (2006.01) TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (21) International Application Number: (84) Designated States (unless otherwise indicated, for every PCT/IB2017/053068 kind of regional protection available): ARIPO (BW, GH, (22) International Filing Date: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 24 May 2017 (24.05.2017) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (25) Filing Language: English EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (26) Publication Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (30) Priority Data: KM, ML, MR, NE, SN, TD, TG). 62/345,315 03 June 2016 (03.06.2016) US Published: (71) Applicants: ABBVIE S.A.R.L. [LU/LU]; 26 Boule- — yard Royal, 2449 Luxembourg (LU). GALAPAGOS NV with international search report (Art. 21(3)) [BE/BE]; Generaal De Wittelaan L 11/A3, 2800 Mechelen (BE). (72) Inventors: ALTENBACH, Robert J.; 7405 N Oketo, Chicago, IL 60631 (US). BOGDAN, Andrew; 944 Michi- gan Avenue Apt. 3W, Evanston, IL 60202 (US). COTI, Ghjuvanni Petru Diunisu; Galapagos NV, Generaal de Wittelaan, Ll1A3, 2800 Mechelen (BE). COWART, Mar- lon D.; 43 Dahlia Lane, Round Lake Beach, IL 60073 (US). GRESZLER, Stephen N; 1175 N. Museum Blvd Apt. 314, Vernon Hills, IL 60061 (US). KELGTERMANS, Hans; Galapagos NV, Generaal de Wittelaan L11/A3, 2800 Mechelen (BE). KYM, Philip R.; 1002 Gracewood Ave, Libertyville, IL 60048 (US). VAN DER PLAS, Steven Emiel; Galapagos NV, Generaal De Wittelaan L 11/A3, 2800 Mechelen (BE). Agent: DUCKWORTH, Timothy John; J A Kemp, 14 = (74) South Square, Gray's Inn, London WC1R 5JJ (GB). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (81) = Title: HETEROARYL SUBSTITUTED PYRIDINES AND METHODS OF USE (54) 1-1 in R 1 x2 11 0,st _ N H2 I 1-1 GC d 1 -5- '\"R 2 0 ei X 1 N IN C 1-1 (57) : The invention discloses compounds of Formula (I), wherein X 1 , X, R 2 1 , and R 2 are as defined herein. The present N invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compo- c sitions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.