Patent ES-2693771-T3 (ES)
Title: Inhibidores de aril lactama quinasa
Inventor: VRUDHULA VIVEKANANDA
IPC: C07D471/04
Filed: 2014-01-29
Granted: 2018-12-13
Abstract: Un compuesto seleccionado de (S)-8-((2-amino-4-metilpentil)oxi)-9-bromobenzo[c][2,7]naftiridin-5(6H)-ona; (S)-8-((2-amino-4-metilpentil)oxi)-9-metilbenzo[c][2,7]naftiridin-5(6H)-ona; (S)-8-((2-amino-4-metilpentil)oxi)-9-isobutil-6-metilbenzo[c][2,7]naftiridin-5(6H)-ona; 8-((2-amino-5,5,5-trifluoropentil)oxi)-6-metilbenzo[c][2,7]naftiridin-5(6H)-ona; 8-((2-amino-5,5,5-trifluoropentil)oxi)-9-bromo-6-metilbenzo[c][2,7]naftiridin-5(6H)-ona; 8-((2-amino-5,5,5-trifluoropentil)oxi)-9-cloro-6-metilbenzo[c][2,7]naftiridin-5(6H)-ona; 4-amino-8-((2-amino-5,5,5-trifluoropentil)oxi)-6-metilbenzo[c][2,7]naftiridin-5(6H)-ona; (S)-8-((2-amino-4-metilpentil)oxi)-9-(difluorometil)-6-metilbenzo[c][2,7]naftiridin-5(6H)-ona; (S)-8-((2-amino-4-metilpentil)oxi)-9-bromo-4,6-dimetilbenzo[c][2,7]naftiridin-5(6H)-ona; 8-((2-amino-5,5,5-trifluoropentil)oxi)-4,6-dimetilbenzo[c][2,7]naftiridin-5(6H)-ona; 8-((2-amino-5,5,5-trifluoropentil)oxi)-9-cloro-4,6-dimetilbenzo[c][2,7]naftiridin-5(6H)-ona; (S)-8-((2-amino-4-metilpentil)oxi)-9-ciclopropil-4,6-dimetilbenzo[c][2,7]naftiridin-5(6H)-ona; 8-((2-amino-5,5,5-trifluoropentil)oxi)-6-metil-5-oxo-5,6-dihidrobenzo[c][2,7]naftiridin-9-carbonitrilo; 8-((2-amino-5,5,5-trifluoropentil)oxi)-9-bromo-4,6-dimetilbenzo[c][2,7]naftiridin-5(6H)-ona; (S)-8-((2-amino-4-metilpentil)oxi)-9-isopropil-4,6-dimetilbenzo[c][2,7]naftiridin-5(6H)-ona; (S)-8-((2-amino-4-metilpentil)oxi)-9-bromo-6-(2-metoxietil)-4-metilbenzo[c][2,7]naftiridin-5(6H)-ona; (S)-8-((2-amino-4-metilpentil)oxi)-9-cloro-6-(2-hidroxietil)-4-metilbenzo[c][2,7]naftiridin-5(6H)-ona; (R)-8-((2-amino-4-metilpentil)oxi)-9-bromo-4,6-dimetilbenzo[c][2,7]naftiridin-5(6H)-ona; (S)-8-((2-amino-4-metilpentil)oxi)-9-bromo-7-fluoro-4,6-dimetilbenzo[c][2,7]naftiridin-5(6H)-ona; 8-(2-amino-4,4,4-trifluorobutoxi)-6-metilbenzo[c][2,7]naftiridin-5(6H)-ona; 8-(2-amino-4,4,4-trifluorobutoxi)-9-bromo-4,6-dimetilbenzo[c][2,7]naftiridin-5(6H)-ona; 8-(2-amino-4,4,4-trifluorobutoxi)-9-bromo-6-metilbenzo[c][2,7]naftiridin-5(6H)-ona; 8-(2-amino-4,4,4-trifluorobutoxi)-9-cloro-6-metilbenzo[c][2,7]naftiridin-5(6H)-ona; (S)-8-((2-amino-4-metilpentil)oxi)-9-clorobenzo[c][2,7]naftiridin-5(6H)-ona; (S)-8-((2-amino-4-metilpentil)oxi)-9-bromo-6-(2-hidroxietil)-4-metilbenzo[c][2,7]naftiridin-5(6H)-ona; 8-metoxi-4,6-dimetilbenzo[c][2,7]naftiridin-5(6H)-ona; (S)-1-(8-((2-amino-4-metilpentil)oxi)-9-fluoro-6-metil-5-oxo-5,6-dihidrobenzo[c][2,7]naftiridin-4-il)-3-metilurea; 8-(2-hidroxi-3-(isopropilamino)propoxi)-6-metilbenzo[c][2,7]naftiridin-5(6H)-ona; 8-(2-hidroxi-3-(isopropilamino)propoxi)-4,6-dimetilbenzo[c][2,7]naftiridin-5(6H)-ona; 9-bromo-8-(2-hidroxi-3-(isopropilamino)propoxi)-6-metilbenzo[c][2,7]naftiridin-5(6H)-ona; 9-bromo-8-(2-hidroxi-3-(isopropilamino)propoxi)-4,6-dimetilbenzo[c][2,7]naftiridin-5(6H)-ona; 8-((2,4-dimetilpentil)oxi)-6-metilbenzo[c][2,7]naftiridin-5(6H)-ona; 6-metil-8-((4-metilpentil)oxi)benzo[c][2,7]naftiridin-5(6H)-ona; (S)-8-((2-hidroxi-4-metilpentil)oxi)-4,6-dimetilbenzo[c][2,7]naftiridin-5(6H)-ona; 8-(2-hidroxi-3-isopropoxipropoxi)-4,6-dimetilbenzo[c][2,7]naftiridin-5(6H)-ona; 9-bromo-8-((2,4-dimetilpentil)oxi)-6-metilbenzo[c][2,7]naftiridin-5(6H)-ona; 8-((2,4-dimetilpentil)oxi)-4,6-dimetilbenzo[c][2,7]naftiridin-5(6H)-ona; 4,6-dimetil-8-((4-metilpentil)oxi)benzo[c][2,7]naftiridin-5(6H)-ona; y 8-((2,4-dimetilpentil)oxi)-6-metilbenzo[c][2,7]naftiridin-5(6H)-ona; o una sal farmacéuticamente aceptable del mismo.