baber/WOPTO huggingface dataset:
Patent DE-69228471-D1 (DE)
Inventor: BUISING CHARISSE MARIE
IPC: C12N15/09
Filed: 1992-12-07
Granted: 1999-04-01
Abstract: The invention relates to improved transformation and regeneration of alfalfa, Medicago sativa. A method is used to transform alfalfa by using particle acceleration. Optimum results with mature cotyledons occurs when bombarding after 24 to 120 hours of imbibing water. Regeneration and transformation of alfalfa is greatly improved by using immature cotyledons or embryos of immature cotyledons for transformation and regeneration Immature cotyledons include those up to about 25 days past pollination, and preferably include cotyledons excised at 10-15 days past pollination, most preferably including those excised at about 10 days past pollination. These cotyledons have a light green to translucent appearance. Plants resulting from bombardment of somatic embryos of immature cotyledons retain regeneration ability.
Patent DE-69229733-D1 (DE)
Inventor: GIRIJAVALLABHAN VIYYOOR
IPC: A61K31/09
Filed: 1992-06-17
Granted: 1999-09-09
Abstract: A compound represented by formula I Ar1-O-M-O-Ar2   I    wherein Ar1 and Ar2 are independently substituted phenyl or substituted pyridinyl, the substituents on said phenyl or pyridinyl being independently selected from one, two or three of (C1-C10) alkyl, (C1-C10) alkoxy, halogen, carbamyl, dialkylcarbamyl, (C1-C10)-alkoxycarbonyl, oxazoyl, and (C1-C10) alkyl substituted by halogen, (C1-C10) alkoxy, hydroxy, or (C1-C10) alkoxycarbonyl; <CHEM>     (C4-C8) alkylene, (C4-C8) alkenylene or     (C4-C8)- alkynylene;     O is oxygen;     R min  is (C1-C3) alkyl or H;     A is oxygen or sulfur; Q is selected from hydrogen, halogen, nitro, (C1-C6) alkyl, (C1-C6) perhaloalkyl, (C1-C6) alkylthio (C1-C6) alkyl sulfonyl; the dotted lines in M-3 and M-4 between carbons 2, 3 and 4, and 5 and 6 mean that the bonds between carbons 2 and 3, and 3 and 4, and 5 and 6, may each be a single or double bond;     n = 1 or 2     m = 1 or 2     p = 0 or 1 and     or pharmaceutically acceptable salts thereof. as well as pharmaceutical compositions containing the compounds and the use of the compounds of formula I for preparation of a medicament for methods of treating or preventing viral infections, especially picornaviral infections, are disclosed.
Patent DE-69301357-D1 (DE)
Inventor: MACOR JOHN EUGENE
IPC: A61P25/30
Filed: 1993-03-25
Granted: 1996-02-29
Abstract: PCT No. PCT/EP93/00738 Sec. 371 Date Oct. 6, 1994 Sec. 102(e) Date Oct. 6, 1994 PCT Filed Mar. 25, 1993 PCT Pub. No. WO93/21177 PCT Pub. Date Oct. 28, 1993   <IMAGE>  (I)  Compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 is a substituted alkylene; C3-C7 cycloalkyl optionally substituted with HO; C3-C6 alkenyl optionally substituted with aryl; C5-C7 cycloalkenyl; or C3-C6 alkynyl; R2 is H; halo; F3C; NC; R8R9NOC; a substituted alkylene; R8R9NO2S; R10S(O)m; R12CON(R11); R10SO2N(R11); R8R9NOCN(R11); R10O2CN(R11); R13(CH2)nCH=CH; or R7O are selective 5-HT1-like receptor agonists useful in the treatment of migraine, cluster headache, chronic paroxysmal hemicrania and headache associated with vascular disorders.
Patent DE-69316178-D1 (DE)
Inventor: BIKANDI NUNO JUAN CARLOS
IPC: H02K1/02
Filed: 1993-07-08
Granted: 1998-02-12
Abstract: The present invention relates to induced rotors such as those used in electromagnetic speed reducers for self-propelled vehicles, power test benches for internal combustion engines and other applications, which are made by using nodular cast iron with a substantially ferritic matrix, with a carbon content comprised between 2.5 % and 4 % by weight calculated on the total weight of the cast iron. The use of said materials, instead of those conventionally used, makes possible the construction of rotors with thinner walls and, consequently lighter in weight and which, while preserving excellent magnetic permeability properties, have a thermal fatigue resitance higher than that of rotors made with conventional materials.
Patent DE-69316765-D1 (DE)
Inventor: SPEER DREW VE
IPC: B01J20/26
Filed: 1993-09-24
Granted: 1998-03-05
Abstract: Improved compositions for scavenging oxygen are disclosed. These materials, characterized by low degree crystallinity and a glass transition temperature of lower than -15 DEG  C., have high oxygen scavenging rates at low temperatures. The composition comprises an ethylenically unsaturated hydrocarbon and a transition metal salt catalyst and can be incorporated into various types of layers. It is preferable that the composition be incorporated into layers of multilayered articles used for packaging oxygen-sensitive products such as food products.
Patent DE-69332153-D1 (DE)
Inventor: RHODES MICHAEL KENNETH ADRIAN
IPC: B26B27/00
Filed: 1993-12-10
Granted: 2002-08-29
Abstract: PCT No. PCT/AU93/00637 Sec. 371 Date Jan. 22, 1996 Sec. 102(e) Date Jan. 22, 1996 PCT Filed Dec. 10, 1993 PCT Pub. No. WO92/13439 PCT Pub. Date Jun. 23, 1994A cutting apparatus (10) comprising a cutting assembly (11) mounted on a mounting member/actuation member (12) which is pivotally connected to an article support member (13) having a receiving portion (14). In use a user may, by tightening his or her grip about the apparatus (10) overcome the resistance provided by the leaf spring (25) and thereby urge the free ends of the mounting member (12) and the article support member (13) together such that the incising end portion (16) of the blade assembly (11) extends through the slit (30) and engages the complementary shaped recess (14) so as to form an incision in the article (50). The user may, while maintaining sufficient pressure on the mounting member/actuating member (12), draw or slide the apparatus (10) relative to the material in a general direction indicated by arrow (51), for example, such that the cutting edge (18) cuts the portion of the material (50) which it bears against.
Patent DE-69333120-D1 (DE)
Inventor: HUBESCH BRUNO ALBERT JEAN
IPC: D06M13/35
Filed: 1993-05-03
Granted: 2003-08-28
Abstract: Compositions are disclosed containing fabric softener compound having two hydrophobic groups attached to the remainder of the compound through ester linkages (DEQA), said compositions being concentrated and containing viscosity/dispersibility modifiers which are single long chain cationic surfactants, highly ethoxylated nonionic surfactants and/or mixtures thereof. Premix mixtures of the DEQA and viscosity modifiers to lower the viscosity of the molten DEQA are disclosed. Processes for making aqueous liquid compositions from solid particulate compositions containing the DEQA and processes of softening fabrics with the compositions are also disclosed.
Patent DE-69404944-D1 (DE)
Inventor: HOPWOOD ROBERT TIMOTHY
IPC: H01M10/14
Filed: 1994-05-17
Granted: 1997-09-18
Abstract: PCT No. PCT/GB94/01053 Sec. 371 Date Dec. 21, 1994 Sec. 102(e) Date Dec. 21, 1994 PCT Filed May 17, 1994 PCT Pub. No. WO94/27897 PCT Pub. Date Dec. 8, 1994.This invention relates to apparatus 10 and methods for loading groups of battery plates or the like in adjacent cells 1 to 6 in a holder. The apparatus includes guide means 13 which defines, by means of walls 37, 38, spaces 40 for receiving respective battery groups 30. The walls can be collapsed around the groups 30 in the spaces 40 until the position and spacing corresponds to that of a row cells 1 to 3, in which point in the groups are pushed through the guide means 13 in to the respective cells.
Patent DE-69409954-D1 (DE)
Inventor: TAYLOR WILLIAM MICHAEL FREDERI
IPC: H04W4/06
Filed: 1994-05-18
Granted: 1998-06-04
Abstract: This is a portable information system which uses Global Positioning System (GPS) data as a key to automatically retrieve audiovisual data from a database. On a journey the system can automatically identify and describe places of specific interest to the user, landmarks and the history of nearby buildings, or locate hotels, hospitals, shops and products within a radius of the present position. Audible menus and voice command give hands-free and eyes-free control while driving, flying, sailing or walking.
Patent DE-69416000-D1 (DE)
Inventor: DESPREZ FRANCOIS
IPC: D21C9/16
Filed: 1994-10-28
Granted: 1999-02-25
Abstract: Method of bleaching chemical paper pulp having undergone extensive cooking, involving a sequence of processing steps carried out without chlorine reagents. The pulp is subjected to decontamination from its transition metals and then to a step using alkaline hydrogen peroxide.
Patent DE-69416936-D1 (DE)
Inventor: AKETA TOMOYUKI
IPC: C08L67/03
Filed: 1994-11-10
Granted: 1999-04-15
Abstract: In a blended resin composition comprising a general polyester and a liquid crystal polyester resin, the liquid crystal polyester resin is fibrillated in the molding step to obtain a resin composition having excellent mechanical strength etc. The present invention relates to a synthetic resin composition comprising 100 parts by weight of a resin component composed of 99 to 50 parts by weight of a polyester resin (a) not forming an anisotropic melt phase and 1 to 50 parts by weight of a liquid crystal polyester resin (b) capable of forming an anisotropic melt phase as well as 0.01 to 0.5 parts by weight of a phosphorus compound (c), said liquid crystal polyester resin (b) capable of forming an anisotropic melt phase is fibrillated to an aspect ratio of 6 or more in the molding step.
Patent DE-69424258-D1 (DE)
Inventor: FRIEDMAN JACOB
IPC: B23D61/04
Filed: 1994-11-15
Granted: 2000-06-08
Abstract: A metal cutting tool assembly comprising a rigid holder blade (1), an insert receiving slot (9) formed in a leading end of the holder blade and defined between a resiliently displaceable clamping jaw (3) formed integrally with the holder blade (1) and rigid base jaw (4) forming part of the holder blade, spaced apart displacement and supporting surfaces respectively formed in or on the clamping jaw (3) and the holder, and a slot opening key (21,33,41) a pair of spaced apart projecting prongs (24a,24b/34a,34b/42a,42b) of the key adapted to engage the surfaces. At least one of the prongs is displaceable with respect to the holder blade so as resiliently to displace the clamping jaw (3) outwardly with respect to the base jaw into an opening position for insertion or removal of an insert (7). <IMAGE>
Patent DE-69432511-D1 (DE)
Inventor: TAJIMA HISAO
IPC: C12N1/21
Filed: 1994-11-24
Granted: 2003-05-22
Abstract: The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the said polypeptide; vector derived the said DNA; host cells transformed the said vector; antibody of the said polypeptide; pharmaceutical composition containing the said peptide or antibody; method for the prevention and/or treatment of diabetes, which is characterized by tyrosine phosphorylation of the said protein p140; agent for the prevention and/or treatment for the currently said the prevention and/or treatment method; agent for the prevention and/or treatment of diabetes, which is characterized by containing a compound which can tyrosine phosphorylation of protein p140, as active ingredient and the screening methods of the said prevention and/or treatment agent. Tyrosine phosphorylation of protein p140 is an essential step in the induction of hypoglycemia by glucose uptake. Method and agent of prevention and/or treatment based on tyrosine phosphorylation of protein p140 in the present invention is not only improve the diabetes-derived hyperglycemic conditions but are also useful for the treatment and/or prevention of diabetes, especially non-insulin dependent diabetes mellitus (NIDDM).
Patent DE-69433107-D1 (DE)
Inventor: ADAMS W
IPC: C12N15/55
Filed: 1994-05-18
Granted: 2003-10-09
Abstract: Substantially purified DNA comprising DNA encoding an amino acid sequence selected from the group consisting of the amino acid sequence of:  (i) Streptococcus Pyogenes DNAse B enzyme as shown in Figure 4; and (ii) a sequence encoding a functional equivalent of S Pyogenes DNAse B enzyme, the DNA being substantially free of DNA that does not encode the amino acid sequence of figure 4 or a functional equivalent of S Pyogenes DNAse B enzyme except for a leader peptide fused to the amino acid terminus of S Pyogenes DNAse B enzyme.  <IMAGE>
Patent DE-69505142-D1 (DE)
Inventor: MCMAHON KEITH HERD YOUNIE
IPC: A61M5/178
Filed: 1995-08-10
Granted: 1998-11-05
Abstract: PCT No. PCT/GB95/01894 Sec. 371 Date Jan. 29, 1997 Sec. 102(e) Date Jan. 29, 1997 PCT Filed Aug. 10, 1995 PCT Pub. No. WO96/05879 PCT Pub. Date Feb. 29, 1996A fluid handling device has a needle retraction assembly which brings about the retraction of a hollow needle after use. A hollow body portion is provided at one end, with an end wall having a mounting portion including a needle passage. A hollow needle having a leading end portion is movable between a first position in which the leading end portion of the needle protrudes from a front end portion of said mounting portion and a second position in which the needle is withdrawn within the hollow body portion. A spring acts to bias the needle into the second, withdrawn position. The needle is provided with a portion of enlarged diameter at a location spaced from the leading end portion. A retainer maintains the needle in its first position until use is completed. The retainer includes an O-ring positioned in a circumferential groove in the portion of enlarged diameter. The O-ring abuts the end of a sleeve slidable within the mounting portion and which can be forced forwardly to dislodge the O-ring so as to permit the needle to move from its first position into its second position under the influence of the spring.
Patent DE-69505246-D1 (DE)
Inventor: VAN LOOSBROEK ALBERT
IPC: G06F17/30
Filed: 1995-04-21
Granted: 1998-11-12
Abstract: An interactive information selection apparatus comprises: memory means in which all necessary information relating to at least one dish consisting of a number of components is or can be stored spread over a number of hierarchical levels; first display means for displaying in each case a list of options corresponding with one level, one of which options at a time can be selected by a user; selection means which can be operated by a user and which are adapted, after a start instruction and on the basis of menu control, to address that part of the memory containing partial information relating to the selected option; which memory means are adapted to activate the following level after addressing of the said memory part until the final level is reached and are also adapted to store each selected option; and second display means for displaying all relevant information present in the memory corresponding with all selected options.
Patent DE-69505596-D1 (DE)
Inventor: DAVIS MICHAEL
IPC: A41D27/10
Filed: 1995-06-01
Granted: 1998-12-03
Abstract: A garment (20) suited for a young child comprises cuffs (30) which are devoid of any hem at their distal end and which have hidden side seams. A pouch (32) overlays the cuff at the distal end. The pouch is invertible over the cuff end to enclose an appendage such as a hand or foot of the wearer within the cuff. When the pouch is not inverted, the cuff may be turned back to expose the appendage. <IMAGE>
Patent DE-69507625-D1 (DE)
Inventor: MUELLER FRANK
IPC: A61J17/00
Filed: 1995-09-01
Granted: 1999-03-11
Abstract: In a child's musical dummy, in which an electronic tune-playing arrangement (not shown) is embedded in the shield (1) and adapted to be controlled from the outside, the main novel feature is that the tune-playing arrangement comprises a magnetically operable contact (not shown), adapted to close the supply circuit to the tune-playing arrangement, when the holding ring (3) is moved to a music position (A), in which a magnet (5) embedded in the ring (3) actuates the contact.
Patent DE-69507702-D1 (DE)
Inventor: BOMBARDELLI EZIO
IPC: A61K31/00
Filed: 1995-07-21
Granted: 1999-03-18
Abstract: The present invention relates to novel derivatives obtained by oxidation and the stereospecific reduction of 10-deacetylbaccatine III, and successive esterification with a variously substituted isoserine chain to prepare taxol analogues. The products of the invention have cytotoxic and anti-tumoural activities and, when suitably formulated, can be administered by injection and/or orally.
Patent DE-69510819-D1 (DE)
Inventor: MISRA MANORANJAN
IPC: C02F9/00
Filed: 1995-01-12
Granted: 1999-08-19
Abstract: Metals contained in various wastewaters are selectively recovered as metal precipitates and/or as spinel ferrite and water suitable for discharge into the environment is obtained. High grade magnetic spinel ferrite is recovered from wastewaters having aluminum and arsenic if present in the wastewater, removed from the wastewater. There are three process stages for the treatment of wastewater. In the first process stage which is optional, at least a portion of at least one non-ferrous or non-ferric metal is precipitated from the wastewater by subjecting the wastewater to an oxidizing agent to increase the oxidation-reduction potential of the water, by adjusting the pH of the wastewater to a pH at which the metal precipitates from the water and by adding an organic or inorganic sulfur compound, capable of causing the metal to form a precipitate, to the water in a quantity sufficient to precipitate the metal. When aluminum is present in the wastewater, aluminum is recovered from the water by adding a reducing agent to lower the oxidation-reduction potential of the water and by adjusting the pH of the water to about 5. The aluminum which precipitates in the aqueous solution, is removed from the water. In the third precipitation stage, iron is recovered as spinel ferrite in an ambient temperature process by adding a reducing agent to the water, adding a soluble ferrous salt to the water, adjusting the pH to about 9-12 and oxidizing the water with an oxidizer, e.g., air, to form spinel ferrite. If aluminum and/or arsenic are present in the wastewater and are removed from the wastewater by the process, high grade magnetic spinel ferrite is recovered.
Patent DE-69517621-D1 (DE)
Inventor: FITTON MICHAEL GEORGES
IPC: B01D61/44
Filed: 1995-04-04
Granted: 2000-08-03
Abstract: The present invention relates to a process for the preparation of a cationic reagent suitable for use in the preparation of cationic starch. The present invention also relates to cationic reagents containing significantly less chloride ions. The invention also relates to cationic starches containing less chloride ions. <IMAGE>
Patent DE-69523608-D1 (DE)
Inventor: DOLAN SHAWN E
IPC: C23C22/80
Filed: 1995-08-23
Granted: 2001-12-06
Abstract: A chromium free conversion coating at least equivalent in corrosion protective quality to conventional chromate conversion coatings can be formed on metals, particularly cold rolled steel, by a dry-in-place aqueous acidic liquid comprising: (A) a component of anions, each of said anions consisting of (i) at least four fluorine atoms and (ii) at least one atom of an element selected from the group consisting of titanium, zirconium, hafnium, silicon, and boron, and, optionally, (iii) ionizable hydrogen atoms, and, optionally, (iv) one or more oxygen atoms; (B) a component of cations of elements selected from the group consisting of cobalt, magnesium, manganese, zinc, nickel, tin, zirconium, iron, and copper; the ratio of the total number of cations of this component to the total number of anions of component (A) being at least 1:5; (C) sufficient free acid to give the composition a pH in the range from 0.5 to 5.0; (D) a component selected from the group consisting of phosphorus-containing inorganic oxyanions and phosphonate anions; and (E) a component selected from the group consisting of water-soluble and water-dispersible organic polymers and polymer-forming resins and, preferably, also including a component selected from the group consisting of tungstate, molybdate, silicotungstate, and silicomolybdate anions.
Patent DE-69524400-D1 (DE)
Inventor: ZELLE EDWARD
IPC: C07C271/18
Filed: 1995-03-23
Granted: 2002-01-17
Abstract: The present invention relates to compounds as represented by formula (I) that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also comprises pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of multi-drug resistance and for use in multi-drug resistant cancer therapy.
Patent DE-69530378-D1 (DE)
Inventor: WIEDERRECHT GREGORY J
IPC: C12N9/90
Filed: 1995-02-10
Granted: 2003-05-22
Abstract: A new homogeneous cytosolic binding protein (FKBP12.6), having a specific binding activity of about 4.8 mg FK-506 per mg protein and a molecular weight of about 10-12 kilodaltons, reversibly binds the immunosuppressant FK-506, but not cyclosporine A (CSA). The protein is unstable to heating at 56 DEG  C. for 30 minutes losing its FK-506 binding affinity. The FKBP12.6 protein is isolated from the cytosol of mammalian tissues, preferably bovine or human brain tissue, and can be used in diagnostic and purification procedures involving FK-506-type macrolide immunosuppressants. The FKBP12.6 protein also has peptidyl-proline isomerase enzymatic activity, catalyzing the cis-trans isomerization of proline-containing peptide bonds. In addition, FKBP12.6 binds to and inhibits the phosphatase calcineurin in the presence of FK-506.
Patent DE-69534079-D1 (DE)
Inventor: FROST JOHN W
IPC: C12N15/09
Filed: 1995-06-08
Granted: 2005-04-21
Abstract: Enhanced efficiency of production of aromatic compounds via the common pathway, as shown in FIG. 1, of a host cell is realized by increasing the expression of enzyme species acting on substrate intermediates in identified rate-limiting reaction steps in the pathway. Prokaryotic cell transformants are described comprising exogenous DNA sequences encoding for the enzymes species, 3-dehydroquinate synthase, shikimate kinase, 5-enolpyruvoyl-shikimate-3-phosphate synthase and chorismate synthase. These transformants can be further transformed with exogenous DNA sequences encoding the enzyme species transketolase and DAHP synthase. In one embodiment of the present invention, one or more of the DNA sequences encoding the enzyme species are incorporated into the genome of the transformant.
Patent DE-69603827-D1 (DE)
Inventor: KUIPER GEORGE G J
IPC: A61P25/28
Filed: 1996-09-09
Granted: 1999-09-23
Abstract: This invention relates to a novel estrogen receptor-related nuclear receptor, hereinafter termed "ER beta " having the amino acid sequence of Figs. 1, 13A or 14A or substantially the same amino acid sequence as the amino acid sequence shown in Figs. 1, 13A or 13B or an amino acid sequence functionally similar to that sequence. The invention also relates to DNA sequences encoding the receptor. The receptor may be useful in isolating molecules for the treatment of disorders such as prostate cancer, benign prostatic hyperplasia, osteoporosis or cardiovascular disorders and in the testing of substances for estrogenic and other hormonal effects.