Patent SG-11201909863Q-A (SG)
Title: Degradable imidazolium oligomer and polymer for antimicrobial applications
Inventor: ZHANG YUGEN
IPC: A01P3/00
Filed: 2018-06-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 03 January 2019 (03.01.2019) WIPO I PCT omit !Immo moll iflo oimIE (10) International Publication Number WO 2019/004940 Al (51) International Patent Classification: CO7D 233/56 (2006.01) A61P 31/00 (2006.01) CO8G 73/06 (2006.01) AO1P 1/00 (2006.01) CO8L 79/04 (2006.01) AO1P 3/00 (2006.01) A61K 31/4164 (2006.01) A01N 43/50 (2006.01) A61K 31/787 (2006.01) (21) International Application Number: PCT/SG2018/050315 (22) International Filing Date: 28 June 2018 (28.06.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201705438U 30 June 2017 (30.06.2017) SG (71) Applicant: AGENCY FOR SCIENCE, TECHNOLO- GY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10 Connexis North Tower, Singapore 138632 (SG). (72) Inventors: ZHANG, Yugen; c/o Institute of Bioengineer- ing and Nanotechnology, 31 Biopolis Way, The Nanos, #04-01, Singapore 138669 (SG). YUAN, Yuan; c/o Insti- tute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, #04-01, Singapore 138669 (SG). LIM, Shu Wen Diane; c/o Institute of Bioengineering and Nan- otechnology, 31 Biopolis Way, The Nanos, #04-01, Singa- pore 138669 (SG). (74) Agent: SPRUSON & FERGUSON (ASIA) PTE LTD; P.O. Box 1531, Robinson Road Post Office, Singapore 903031 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) (54) Title: DEGRADABLE IMIDAZOLIUM OLIGOMER AND POLYMER FOR ANTIMICROBIAL APPLICATIONS X - \ N linker 2 1=1 X' fi- - -N —N [ 1 linker 1 -linker 1 N x- ...--- q NN x- Formula (I) /=\ /=\ linker 2—N „ ,, ,„.N ± —linker 1 —N v N n Formula (II) (57) : The present invention relates to an imidazolium oligomer of formula (I) and an imidazolium oligomer or a polymer of formula (II) where the various groups are as defined in the specification. The present invention also relates to the methods for their preparation, antimicrobial composition, antimicrobial gel containing these oligomers and/or polymers of Formula (I) and (II), and uses of these oligomers and/or polymers in the treatment of a microbial infection or disease.