baber/WOPTO huggingface dataset:
Patent IL-144029-A0 (IL)
Title: Soluble receptor br43x2 and methods of using
IPC: A61P37/00
Filed: 2000-01-07
Abstract: There is provided a fusion protein consisting of a first portion and a second portion joined by a peptide bond, wherein said first portion consists of an amino acid sequence selected from: (i) amino acid residues 25-104 of SEQ ID NO: 6; (ii) amino acid residues 34-66 of SEQ ID NO: 6; (iii) amino acid residues 71-104 of SEQ ID NO: 6; and (iv) amino acid residues 34-66 and 71-104 of SEQ ID NO: 6; and said second portion is an immunoglobulin heavy chain constant region. There is also provided an antibody or antibody fragment that specifically binds to a polypeptide selected from SEQ ID NO: 59 or SEQ ID N: 60. There is also provided an antibody or antibody fragment that specifically binds to a ztnf4 polypeptide, for use in treating systemic lupus erythematosus in a mammal.
Patent IL-155785-A0 (IL)
Title: PROCESS FOR THE ENZYMATIC PREPARATION OF ENANTIOMERICALLY ENRICHED beta-AMINO ACIDS
IPC: C07C229/34
Filed: 2003-05-06
Abstract: Production of enantiomerically enriched, N-unprotected beta-amino acids (I) comprises enzymatic hydrolysis of an enantiomeric mixture of N-unprotected beta-aminoacid esters (II) using a hydrolase, provided that (II) is other than a methyl or ethyl ester.  An Independent claim is also included for new beta-aminoacid n-propyl esters of formula (II'). R = 1-8C alkyl, 2-8C alkenyl, 2-8C alkynyl, 3-8C cycloalkyl (optionally substituted by 1-3 1-8C alkyl), 6-18C aryl (optionally substituted by 1-3 1-8C alkyl), 7-19C aralkyl, 3-18C heteroaryl (optionally substituted by 1-3 1-8C alkyl) or 4-19C heteroaralkyl; and R' = H or as defined for R.
Patent IL-172683-A0 (IL)
Title: Cancer combination therapy comprising azd2171 and zd1839
IPC: A61P35/00
Filed: 2005-12-19
Abstract: The present invention relates to a method for the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human which is optionally being treated with ionising radiation, particularly a method for the treatment of a cancer, particularly a cancer involving a solid tumour, which comprises the administration of AZD2171 in combination with ZD1839; to a pharmaceutical composition comprising AZD2171 and ZD1839; to a combination product comprising AZD2171 and ZD1839 for use in a method of treatment of a human or animal body by therapy; to a kit comprising AZD2171 and ZD1839; to the use of AZD2171 and ZD1839 in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human which is optionally being treated with ionising radiation.
Patent IL-178513-A0 (IL)
Title: Method for the production of a cell composition containing epithelial cells
IPC: C12N5/00
Filed: 2006-10-05
Abstract: Disclosed is a method for forming epithelial cells. Said method comprises the steps of aggregating stem cells from differentiated exocrine gland tissue to obtain an organoid body and differentiating at least one portion of the organoid body or a tissue body grown therefrom to obtain epithelial cells. Also disclosed is a cultivation device, particularly for forming differential epithelial cells.
Patent RO-127258-A0 (RO)
Title: System for monitoring and remotely signalling certain parameters of the human body
Inventor: MATEI OLIVIU DORIN
IPC: A61B5/00
Filed: 2011-09-23
Abstract: The invention relates to a system for monitoring and remotely signalling certain parameters of the human body. According to the invention, the system consists of a sensorial module (8) comprising a sensor (9) for pulse, temperature etc., taking over the signal from a person and transmitting it to an amplifier (10) and further to a micro controller (11) which processes the received information and decides if there are sensible variations, as compared with some acceptable values, which are worth being transmitted by means of a wire or wireless communication interface (12) to a communication equipment (1) consisting of the following components: an interface (2) similar to the communication interface (12), an antenna (3), a telephone interface (4), a processor (6) processing the received information and deciding if the values sensed by the sensor (9) range within the normal limits, otherwise a message being displayed on a screen (7) and the received information together with the geospatial coordinates provided by a GPS (5) being transmitted as a voice or written message, while an application (13) displays on a map (14) the monitored person's location and the shortest ways thereto, by means of a software module (15).
Patent AU-2002952548-A0 (AU)
Title: Diagnostic assay
IPC: C12Q1/68
Filed: 2002-11-08
Abstract: The present invention relates generally to a diagnostic assay and, more particularly, an assay for measuring cell-mediated immune reactivity. Even more particularly, the present invention provides an assay and a kit for measuring a cell-mediated response to an antigen using whole blood or other suitable biological sample. The assay may be conducted using ligands to immune effector molecules or at the nucleic acid level, screening for expression of genes encoding the immune effector molecules. The assay is useful in therapeutic and diagnostic protocols for human, livestock and veterinary and wild life applications.
Patent LU-85388-A1 (LU)
Inventor: SCHENK HEINRICH
IPC: H03H21/00
Filed: 1984-05-30
Abstract: For digital signal processing with a transversal filter having a (N-1) stage delay chain which is fed at its input with the digital signal to be processed and is provided with taps, subsum signals are stored which correspond to the N/w consecutive groups of, in each case Aw possible combinations of, in each case, w consecutive, A-value tapped signal elements, where the subsum signals are formed from tapped signal elements which are each assigned to a group and are evaluated in accordance with the relevant filter setting. During each delay stage, in accordance with the relevant N/w actual combinations tapped elements, the associated subsum signals are successively read from a memory and added to one another to form an output signal element. The subsum signals can be iteratively formed in that each of the successively-read subsum signals, combined with a correction value, forms a corrected subsum signal which is stored in place of the read subsum signal as a new subsum signal.
Patent MA-19162-A1 (MA)
Inventor: G A MARKUS
IPC: F23R3/06
Filed: 1981-06-01
Abstract: A fuel reactor having an outer frusto-conical shell which is closed at one axial end and a fuel inlet at this axial end projects fuel axially into the outer shell and into an inner shell mounted coaxially therewith, the inner and outer shells being connected together at the discharge end of the inner shell, with the inner shell being open at its other end and axially spaced from the closed end of the outer shell. A tangential combustion air inlet is connected to the annular space between the two shells while a discharge nozzle is mounted on the discharge end of the inner shell. A number of circumferentially spaced tangential slots in the inner shell adjacent the nozzle scoop up some of the swirling air projected in through the tangential air inlet and direct some of the air onto the outer surface of the discharge nozzle so that it is cooled.
Patent MA-20150380-A1 (MA)
Title: Agent de lutte contre les parasites et/ou les maladies des plantes
Inventor: ARIMOTO YUTAKA
IPC: A01P7/04
Filed: 2013-10-11
Abstract: L'objet de la présente invention est de fournir un agent de lutte contre les parasites et/ou les maladies des plantes qui est sans danger pour l'environnement et présente d'excellents effets antiparasitaires. Cet agent de lutte contre les parasites et/ou les maladies des plantes comprend un ester polyglycérolique d'acide gras utilisé comme principe actif, l'ester polyglycérolique d'acide gras étant un ester d'au moins un type d'acide gras choisi parmi des acides gras ayant de 8 à 10 atomes de carbone et d'au moins un type de polyglycérol dans lequel sont polymérisés 3 à 10 motifs polyglycérol.
Patent MA-38418-A1 (MA)
Title: Nouveaux composés
Inventor: LIENAU PHILIP
IPC: C07D498/08
Filed: 2014-03-17
Abstract: La présente invention concerne des n-[3-(acétylamino)phényl]-phényl-hétéroaryl-carboxamides et des n-(phényl-hétéroaryl)-3-acétylamino-benzamides substitués de formule générale (i) tels que décrits et définis dans la description. L'invention porte également sur des procédés de préparation desdits composés, des composés intermédiaires utiles pour la préparation de ces composés, des compositions pharmaceutiques et des combinaisons comprenant lesdits composés et l'utilisation desdits composés pour la fabrication d'une composition pharmaceutique pour le traitement ou la prophylaxie d'une maladie.
Patent MA-40309-A1 (MA)
Title: Anticorps anti-cd73 et leurs utilisations
Inventor: HUANG RICHARD
IPC: C07K16/40
Filed: 2017-05-19
Abstract: La présente invention concerne des anticorps monoclonaux isolés, en particulier des anticorps humains, qui se lient au marqueur de différenciation 73 (cd73) humain avec une grande affinité et inhibent l'activité du cd73, et éventuellement gèrent l'internalisation du cd73 dépendant des anticorps. L'invention concerne également des molécules d'acide nucléique codant pour les anticorps selon l'invention, des vecteurs d'expression, des cellules hôtes et des procédés pour exprimer les anticorps selon l'inventi
Patent MA-54575-A1 (MA)
Title: Revêtement transparent superhydrophobe et antisalissure exempt de fluor pour béton et mortier de ciment
Inventor: BRICHE SAMIR
IPC: C09D183/08
Filed: 2021-09-29
Abstract: La présente invention concerne un procédé d’imprégnation de la surface du béton et façade murale en mortier, par une suspension superhydrophobe constituée de polydimethylesiloxane (pdms) pour leurs conférer des propriétés barrière à l’eau et aux produits corrosifs permettant de rendre la surface antisalissure. Le procédé comprend l’application d’une suspension superhydrophobe sous forme de sol polymérique de polydimethylesiloxane (pdms) à la surface du béton ou du mortier. Suivi d’une étape de séchage.
Patent UY-24073-A1 (UY)
Title: Fabricacion de 2-(2,4- difluorofenil)-1,3-bis (1h-1,2,4-triazol-1-il)- propan -2-ol
Inventor: SAVOI GASTON
IPC: A61K31/4196
Filed: 1995-10-30
Abstract: Procedimiento para la preparación del compuesto 2-(2-4-difluorfenil)-1,3-bis(1H-1,2,4-triazol-1-il)-propan-2-ol (Fluconazol) de fórmula general (I) representada en la figura 1; el procedimiento parte de la sal sódica de 2-(2,4- difluorofenil )-1,3-bis(1H-1,2,4- triazol -1-il)-propan-2-ona, de fórmula general (II) representada en la figura 2, la cual se hace reaccionar con ácido acético glacial (III) para dar así el Fluconazol. El proceso productivo que se lleva a cabo es el siguiente: a- (II) + agua desionozada, calentándolo hasta disolución total entre 80ºC y 110ºC; b- agregar carbón activado; c- filtrar a vacío; d- lavar el carbón con agua desionizada, e- a la solución límpida obtenida se le agrega ácido acético glacial, manteniéndose a 80ºC y agitar; f- enfriar a 10 - 15ºC agitando 4 horas hasta precipitación total; g- filtrar y lavar con agua desionizada; h- secar 24 horeas a vacío a 60- 70ºC obteniéndose el producto final (I). El producto final se utiliza para la preparación de medicamentos antimicóticos.
Patent UY-26073-A1 (UY)
Title: Formas de dosis orales
Filed: 2000-03-23
Abstract: Esta invención proporciona formas de dosis oral discretas, típicamente tabletas o cápsulas, que contienen (2S, 3S, 5R -2-(3,5-difluorofenil 3,5-dimetil-2-morfolinol o una sal fisiológicamente aceptable, o un solvato del mismo o un solvato de dicha sal, y una cantidad de estabilizante efectiva de ácido algínico. Estas formas de dosis son útiles para prevenir o tratar el trastorno o depresión hipercinética de la deficiencia de la adición a productos que contienen nicotina, especialmente productos que contienen tabaco, tales como los que ayudan al cese de fumar.
Patent DZ-2549-A1 (DZ)
Inventor: HARDING VALERIE DENISE
IPC: A61K31/52
Filed: 1998-07-01
Granted: 2003-02-08
Abstract: PCT No. PCT/EP98/04176 Sec. 371 Date Jan. 27, 2000 Sec. 102(e) Date Jan. 27, 2000 PCT Filed Jul. 1, 1998 PCT Pub. No. WO99/01135 PCT Pub. Date Jan. 14, 1999The present invention provides an aqueous pharmaceutical composition comprising 5 to 200 mg/ml of eletriptan hemisulfate and from 0.5 to 2.0% weight/volume of caffeine.
Patent ES-164878-A1 (ES)
Title: MEJORAS INTRODUCIDAS EN LAS HERRAMIENTAS PERCUTORAS AUTOMáTICAS
Filed: 1944-02-21
Abstract: Mejoras introducidas en las herramientas tales como granetes punzones de grabar sacabocados etc. de percusión automática por martillo interior accionado por presión sobre el mango en las cuales la retención del martillo contra el resorte de percusión se realiza por la acción de bolas movibles en orificios practicados en una pared fija de grueso inferior a su diámetro y que pueden penetrar por una parte en rebajos o análogos solidarios de martillo para enclavar éste contra la acción del resorte de percusión y por otra parte en rebajos o análogos solidarios de una pieza de retención con el fin de libertar el martillo pudiendo además dichas mejoras en las herramientas citadas presentar las características siguientes separadamente o en combinación: a). La pieza de retención es desplazada por el mango en fin de carrera contra la acción de un resorte de retorno que después de volver a subir el mango lo vuelve a su posición normal en cuanto el martillo ha vuelto a su vez a su posición de partida y ha presentado sus rebajos de enclavamiento a las bolas que al entrar en ellos han libertado dicha pieza de retención. b). La pared que tiene las bolas es solidaria con juego de la punta punzón u otra herramienta. c). El martillo es cilíndrico y la pared portabolas es un casquillo en cuyo interior resbala aquél siendo la pieza de retención un anillo que resbala sobre dicho casquillo. d). La carrera del martillo con relación al mango de accionamiento es limitada por un sistema de rebordes-topes o análogos de tal manera que al volver a subir el mango bajo la acción de un resorte de retorno apropiado no sea necesario que el resorte de percusión vuelva al estado libre para permitir la nueva subida del martillo y su nuevo encaje. e). En el caso previsto arriba el sombrerete en que se apoya el resorte de percusión es regulable en su posición con relación al mango movible con el fin de permitir dar a dicho resorte una carga inicial variable y regular así la fuerza de la percusión.
Patent ES-178209-A1 (ES)
Title: UN SISTEMA DE COMUNICACIoN ELECTRICA
Filed: 1947-05-16
Abstract: Unos perfeccionamientos en los dispositivos de sujeción y de guía de las pinzas con que se conducen y maniobran los clavos en las máquinas extrarrápidas para fabricar clavazón caracterizados por reducir las vibraciones perturbadoras ocasionada por el aumento de velocidad de la máquina doblado el número de excéntricos determinados de las traslaciones horizontales componentes de la trayectoria de las pinzas pero haciéndolas girar a mitad de velocidad con lo que el número de traslaciones será igual pero cada choque entre los excéntricos con el rodillo será de menos violencia. Al efecto estos excéntricos se sitúan un eje paralelo al principal de la máquina apoyado en un sistema de cojinetes a bolas y se hará girar a la mitad de velocidad del principal
Patent ES-190768-A1 (ES)
Title: UN SISTEMA DE FORJADO DE HORMIGoN ARMADO
Filed: 1949-12-10
Abstract: Sistema de forjado de hormigón armado formado por varios bloques iguales que tienen en su contorno cualquier forma geométrica apropiada y sus límites superior e inferior están limitadas por superficies respectivamente convexas y cóncavas tales que sus secciones principales son curvas parabólicas caracterizado porque se yuxtaponen dichos bloques que constituyen el encofrado de modo que sus bordes formen semi-concavidades donde se introducen los hierros de la armadura y disposniéndose la capa de relleno necesaria sobre estas semi-concavidades hasta alcanzar unnivel ligeramente superior al bloque; pudiéndose estas armaduras disponerse en una o más direcciones según la forma del contorno de los bloques.
Patent ES-191679-A1 (ES)
Title: UN PROCEDIMIENTO PARA LA OBTENCIoN DE PRODUCTOS INYECTABLES
Filed: 1950-02-15
Abstract: Procedimiento para la obtención de productos inyectables con productos escasamente solubles en agua o insolubles en absoluto caracterizándose porque se prepara una solución acuosa de un disolvente orgánico que tiene una gran capacidad disolvente para el componente activo y en el que se incorpora dicho componente excediendo la solubilidad de dicho disolvente en agua limitada como lo está de la del componente activo mientras que la concentración de este último en el disolvente es tal que al efectuarse una disolución de la emulsión con agua tiene lugar una separación del componente en forma sólida.
Patent ES-195836-A1 (ES)
Title: UN APARATO PARA PONER EL ETuN EN CONSERVA
Filed: 1950-12-18
Abstract: Un aparato para poner atún en conserva caracterizado porque tiene una serie de bastidores arrastrados de manera que permanezcan constantemente en posición horizontal por una cadena sin fin uno de cuyos tiros pas por dentro de un horno de túnel de desecación y cocción; comprendiendo cada bastidor dos marcos enrejados entre los cuales se disponen grupos de moldes cilíndricos abiertos en sus dos caras y de dimensiones que corresponden a las de los envases de conserva.
Patent ES-196438-A1 (ES)
Title: UN DISPOSITIVO DE DESCARGA DE ALTA PRESIoN
IPC: H01J17/04
Filed: 1951-02-06
Abstract: Un dispositivo de descarga eléctrica del tipo que emplea un agente ionizable y comprende una envoltura exterior un par de electrodos termoiónicos principales espaciados dentro de la envoltura y un electrodo de arranque conductor situado relativamente cerda de uno de los electrodos principales y construído para obtener una emisión de electrones para impedir que se establezca un potencial unidireccional entre él y el electrodo principal mencionado.
Patent ES-267919-A1 (ES)
Title: Improvements in processes for nitrosating cyclohexylic compounds
Filed: 1961-05-25
Abstract: Caprolactam is prepared by nitrosation of hexahydrobenzoic acid, a functional derivative thereof, or cyclohexylketones of the formula: <FORM:0950513/C2/1> where Y is a hydrocarbon radical, by treating with an agent capable of forming NO+ ions in the reaction medium, in the presence of fuming sulphuric acid, by mixing the reagents at below 35 DEG C. and then heating in a thin layer to produce the caprolactam. Nitrous anhydride, or nitrosyl sulphate may be used as nitrosating agents at a temperature between 75 DEG and 140 DEG C. The process may be batchwise or continuous with recycling and examples describe the nitrosation of hexahydrobenzoic acid and ketones in an apparatus in which the heat of formation of the mixture is removed in a cooler at -18 DEG C., and the reaction takes place in a two-sectional bubble cooler heated to 100 DEG C. The product is cooled, a portion recycled and periodically a portion separated, the hexahydrobenzoic acid present hydrolysed, and the caprolactam extracted with chloroform. <PICT:0950513/C2/1>
Patent ES-290703-A1 (ES)
Title: Improvements in or relating to nuclear reactor operation
IPC: G21C17/04
Filed: 1963-08-08
Abstract: In a gas- or vapour-cooled nuclear reactor, leaks in the sheathing of the fuel elements are detected by causing an emission of fission products through the leak into the coolant fluid by reducing the volume of the interspace between the sheath and fissile material. The speed of coolant circulation and the reactor power are increased together, in steps, so as to maintain the sheath temperature constant while raising the fuel temperature. The fuel expansion thus reduces the interspace. The method is said to detect " fast bursts ", that is, those caused by faulty welding whereby the ingress of oxidizing coolant gas would cause fracture of the sheath by the formation of uranium oxide.
Patent ES-297659-A1 (ES)
Title: Methods for protecting plants and seeds from fungi
IPC: A01N31/16
Filed: 1964-03-14
Abstract: Compounds for treating seeds, to render them resistant to fungi, have the formula wherein R is Me or Et, A is F, CP, Br, Meo, Me or Et and B is F, Cl, Br or Me. In example 3, a composition comprising 1, 4-dichloro-2, 5-dimethoxybenzene, silica, fuller's earth, sodium dioctyl sulphosuccinate, sodium lignin sulphonate, dieldrin and micaceous talc is used to treat cotton seeds in example 13, a composition of 1, 4-dibromo-2, 5-diamelhoxybenzene and micaceous talc is used.
Patent ES-311404-A1 (ES)
Title: Pipe mounting
IPC: F16L3/123
Filed: 1965-04-03
Abstract: A mounting for attaching pipework to a surface comprises a base 2, an open ended band 5 integral with the base and a separate closing device having near one end two spaced abutments 13, 14 for selectively engaging one end of the band and tightening means at its other end for engaging the other end of the band and adapted to be tightened to a limited extent to clamp the band around a portion of the pipework. As shown, the closing device is a bolt 8 and a nut 12, the tightening of which is limited by a cross-piece 18. The abutments 13, 14 and the cross-piece 18 engage the band with a line contact and the whole mounting is moulded from a plastics material.
Patent ES-338928-A1 (ES)
Title: Heel plate for ski bindings
IPC: A63C9/086
Filed: 1967-04-05
Abstract: A metal heel plate for ski bindings, which may be secured to the ski surface to underlie the ski boat heel, has a pair of integral upstanding flanges between which the boot heel fits, each flange having an eye for attachment of a thong or safety strap and being connected to the metal plate by a curved connecting portion of internal radius at least 5 mm., each connecting portion being permanently deformable to permit bending of the flanges towards or away from one another to accommodate ski boots of differing heel size.
Patent ES-339185-A1 (ES)
Title: Apparatus for assembling continuous tubular article from two or more continuous partitubular sections
IPC: A24D3/02
Filed: 1967-04-12
Abstract: An apparatus for assembling an elongate tubular article composed of at least two elongate body portions enclosing an elongate strip of material therebetween, comprises a first conveyer, e.g. a lower chain assembly 32, for engaging one such elongate body portion 13, a second conveyer, e.g. an upper chain assembly 30, for engaging the other body portion 11, means for advancing such body portions when engaging the conveyers, and means for supplying an elongate flat strip of material 14 between such body portions said first conveyer having a straight run portion for co-operation with a portion of said second conveyer spaced from said straight run portion to force such elongate body portions into mutually interfitting relationship to form an elongate tubular article. The chain assemblies 30, 32 comprise links 44 supporting blocks 50 that run in guide tracks 70, 71, 72, 73, the chains being driven in synchronism by sprockets 34, 36. The blocks 50 include registration pins 58 for engaging shoulders 90 formed in the body portions 11, 13. As exemplified, the body portions 11, 13 comprise shell sections having internal ribs 80 and smoke barriers 81 formed therein, and the continuous strip 14 comprises filter strip material. One or other of the body portions 11, 13 has adhesive applied along its edges that mate with the other body portion prior to feeding to the apparatus, and the united tube formed is subsequently cut into sections to form tobacco-smoke filters. In another embodiment (Figs. 7, 8, not shown), the upper chain assembly 30 is replaced by a power driven registration wheel (170) that similarly includes registration pins (172) and is synchronized with the lower chain assembly (160).