baber/WOPTO huggingface dataset:
Patent EP-1634080-A2 (EP)
Inventor: HAIN JENS
IPC: G01N33/50
Filed: 2002-10-31
Abstract: la présente invention concerne une méthode d'identification de molécules spécifiques d'une maladie dans des cellules animales ou humaines. Cette méthode consiste à : (a) identifier des liquides organiques d'origine animale ou humaine, prélevés sur des animaux ou des humains non touchés par ladite maladie, qui sont cytotoxiques pour les cellules animales ou humaines portant des molécules spécifiques de la maladie ; (b) faire incuber des fractions desdites cellules d'origine animale ou humaine portant des molécules spécifiques de la maladie avec des liquides organiques cytotoxiques prélevés sur des animaux ou des humains non touchés par la maladie identifiés à l'opération (a) et avec des cellules d'origine animale ou humaine portant des molécules spécifiques de la maladie ; (c) identifier des fractions qui interfèrent avec la toxicité desdits liquides organiques pour des cellules d'origine animale ou humaine et ;(d) éventuellement, poursuivre le fractionnement des fractions qui se sont révélées positives à l'opération (c)  et répéter les opérations (b) et (c) jusqu'à ce qu'une fraction homogène soit identifiée, ladite fraction homogène représentant les molécules spécifiques de la maladie. En variante, on peut : (b') diviser les liquides organiques identifiés à l'opération (a) en au moins deux parties et éliminer de l'une des deux parties les molécules induisant une cytotoxicité, (c') soumettre des molécules extraites desdites cellules animales ou humaines et portant des molécules spécifiques de la maladie à des techniques de séparation garantissant une identification incontestable de chaque molécule, (d') faire incuber lesdites molécules séparées alternativement avec une partie dudit liquide organique dont les molécules induisant une cytotoxicité cytotoxique n'ont pas été éliminées et avec une partie dudit liquide organique dans lequel les molécules induisant une cytotoxicité ont été éliminées, (e') identifier les molécules qui sont reconnues par la partie de liquide organique qui renferme des molécules induisant une cytotoxicité, mais pas par la partie dudit fluide qui a été débarrassée des molécules induisant une cytotoxicité. La présente invention concerne également l'identification d'inhibiteurs ou d'antagonistes de la molécule ainsi identifiée et la modification apportée à de tels inhibiteurs ou antagonistes dans le but d'en améliorer les propriétés pharmacologiques. Enfin, dans un mode de réalisation hautement préféré, l'invention concerne la formulation d'un inhibiteur ou d'un antagoniste identifié ou amélioré dans une composition pharmaceutique. L'approche suivie dans le cadre de la présente invention peut être qualifiée d'approche théranostique.
Patent EP-1488233-A2 (EP)
Inventor: LEWIN DAVID A
IPC: C07K14/47
Filed: 2002-10-09
Abstract: L'invention concerne des gènes dont la régulation est différenciée, à l'état alimenté et à l'état à jeun. Ces gènes et leurs polypeptides codés s'utilisent pour lutter contre l'obésité et d'autres troubles métaboliques.
Patent EP-1414377-A2 (EP)
Inventor: MERCHANT ALAN C
IPC: A61B17/17
Filed: 2002-08-06
Abstract: Ce composant rotulien prothétique (32) présente une base (24) et un élément de support (22). La base (24) est fixée à une surface rotulienne extérieure. L'élément de support (22) comprend des première et seconde surfaces (40, 42) de contact fémorales disposées entre les première et seconde surfaces latérales (28, 30) et séparées par un pic convexe (44). Les première et seconde surfaces latérales (28,30) présentent une transition graduelle et arrondie d'une partie presque frontale postérieure (46) à une partie presque frontale supérieure ou inférieure (48), des parties de surface adjacentes ayant un déplacement angulaire relatif inférieur à 30 degrés environ. La dimension inférieure-supérieure est d'au moins environ 90 % de la dimension médiale-latérale. La hauteur relative additionnelle et les bords de transition graduelle réduisent de manière significative la probabilité d'une rotation postérieure soudaine pendant un profond mouvement de flexion prononcé. Le composant rotulien (32) peut être employé dans un système de d'articulation fémoro-rotulienne qui reçoit un implant de fémur prothétique comprenant une échancrure throchléaire. L'implant fémoral (70) présente une surface de support médiale (72), une surface de support latérale (74) et un canal (76) disposé entre les deux. L'implant fémoral (70) comprend en outre une surface postérieure (84) ayant une inclinaison maximale au niveau de la section transversale latérale-médiale inférieure à 42 degrés environ, ce qui réduit la nécessité d'enlever de l'os. L'implant fémoral (70) comprend également des points d'ancrage (86) s'étendant vers l'extérieur sensiblement parallèles les uns aux autres et configurés pour être fixés à l'intérieur des alésages préparés dans le fémur.
Patent EP-1448783-A2 (EP)
Inventor: CATTEEUW MARNIX
IPC: C12M1/21
Filed: 2002-11-20
Abstract: A foam separation step is used in fermentation methods and processes. In one aspect, a method comprises seasonally engaging and disengaging a foam separation device amongst alternating ones of a plurality of batch fermentors in accordance with a logistically predetermined cycle whereby the foam separating device is operably engaged to alternating ones of the fermentors for respective periods corresponding to transient periods of over-foam production in each such fermentor, and wherein fermentations are initiated in each of respective ones of the fermentors such that respective transient periods of over-foam production therein are mutually non-concurrent. In another aspect, a foam separation and treatment process comprising drawing over-foam production from a fermentor, breaking the foam to provide separable gas and liquid streams, and treating the liquid and returning the treated liquid to the fermentor. The foam is preferably broken in a mechanical foam separation device, and an adsorbent is used to collect foam-concentrated materials that are entrained in the liquid portion of the foam.
Patent EP-1352752-A2 (EP)
Inventor: UWAGAKI HIDEO
IPC: B41J13/076
Filed: 2003-04-11
Abstract: An object of the invention is to provide a simple-structure
paper conveying apparatus in which variation in a
load imposed on paper is reduced to suppress printing
irregularities, and also provides a printer. The pair of
rollers of the second conveying apparatus (12), arranged at
a predetermined interval away from the first conveying
apparatus (11), are composed of the rotationally-driven
driving roller (112) and the driven roller (17-21) which is
trailingly rotated, with paper being gripped between the
driving roller (112) and driven roller (17-21). The pairs
of rollers of the second conveying apparatus (12) are
arranged in different positions along the paper conveying
direction (52). The paper gripping pressure of the pair of
driving rollers arranged on the upstream side along the
paper conveying direction (52) is set to be lower than that
of the other pairs of driving rollers.
Patent EP-1361350-A2 (EP)
Inventor: MOTEKI KATSUYA
IPC: F02B75/04
Filed: 2003-05-09
Abstract: A link mechanism (1) of an engine includes: an upper link (4) having a first
end connected to a piston pin (3) of a piston (2); a lower link (7) connected to the
upper link (4) via an upper pin (10) having a center (H), the lower link (7) being
connected to a crank pin (6) of a crank shaft (5: 6, 12, 13); a control shaft (8: 14, 15)
extending substantially in parallel with the crank shaft (5: 6, 12, 13), the control
shaft (8: 14, 15) having a rotational center (B); and a control link (9) including: a
first end swingably connected to the control shaft (8: 14, 15), and a second end
connected to the lower link (7). In a process of the center (H) of the upper pin (10)
moving nearer to the axial line (G) of the piston pin (3), the center (J) of the control
pin (11) moves in the upward direction, thus inclining the lower link (7) and
allowing the center (H) of the upper pin (10) and the center (F) of the piston pin (3)
to move in the downward direction.
Patent EP-1385215-A2 (EP)
Inventor: NAGAHAMA SHINICHI
IPC: H01L33/62
Filed: 2003-07-08
Abstract: A substrate 1 for growing nitride semiconductor has a first and second
face and has a thermal expansion coefficient that is larger than that of the
nitride semiconductor. At least n-type nitride semiconductor layers 3 to 5, an
active layer 6 and p-type nitride semiconductor layers 7 to 8 are laminated to
form a stack of nitride semiconductor on the first face of the substrate 1. A
first bonding layer including more than one metal layer is formed on the p-type
nitride semiconductor layer 8. A supporting substrate having a first and
second face has a thermal expansion coefficient that is larger than that of the
nitride semiconductor and is equal or smaller than that of the substrate 1 for
growing nitride semiconductor. A second bonding layer including more than
one metal layer is formed on the first face of the supporting substrate. The
first bonding layer 9 and the second bonding layer 11 are faced with each other
and, then, pressed with heat to bond together. After that, the substrate 1 for
growing nitride semiconductor is removed from the stack of nitride
semiconductor so that a nitride semiconductor device is provided.
Patent EP-1376819-A2 (EP)
Inventor: MATSUNAGA KAZUO
IPC: H02K19/22
Filed: 2000-09-07
Abstract: An alternator is capable of preventing a short circuit at a
coil end, improving an ability of cooling a stator winding
assembly, and reducing noises. A multi-phase stator winding
of the alternator has: a plurality of joint portions where a
distal end extending in an axial direction of a first
conductor portion drawn out from a first layer in a slot and
a distal end extending in an axial direction of a second
conductor portion drawn out from a second layer in a slot
located a predetermined number of slots apart in a
circumferential direction are connected outside the slot on
an end surface side of the stator core; and a coil end where
the joint portions are disposed in a plurality of rows in the
circumferential direction. The distance between an inner
joint portion located on an inner peripheral side of a stator
core and an end surface of the stator core is different from
the distance between an outer joint portion located on an
outer peripheral side of the stator core and the end surface
of the stator core.
Patent EP-1493551-A2 (EP)
Inventor: KOSLOWSKI ARTUR
IPC: B31F1/07
Filed: 2003-07-11
Abstract: In the manufacture of tissue paper products of defined embossed surface appearance, the paper is embossed by a rolling drum bearing a commensurate relief profile. The drum profile is formed by a roller engraving machine and has identical lines of relief dots, each axially transposed with respect to the next. The embossing patterns fill an area between 225 mm 2>and 25,000 mm 2>.
Patent EP-1382881-A2 (EP)
Inventor: HUMM SIEGFRIED
IPC: F16F1/393
Filed: 2003-07-16
Abstract: The fastener for mounting pipes on ceilings comprises an outer two-part sleeve (1a, 1b) and an inner plug (11) with a bi-conical shape. These have serrated surfaces (7, 8, 13) which face each other . A flexible sleeve (14) is mounted between these which is compressed when a bolt in the plug is tightened.
Patent EP-1354560-A2 (EP)
Inventor: ROBERTSON JOHN CHARLES
IPC: A61B17/28
Filed: 1995-05-17
Abstract: A surgical instrument for applying at least one array of
fasteners comprising:
   a handle section;   a curved body portion extending from the handle section;   a fastener head portion connected to the body portion
and including a plurality of fasteners;   an elongated member operatively connected to the handle
section and extending at least partially through the curved
body portion, the elongated member including a distal end
including at least two flexible bands, the elongated member
being movable between a first position and a second position;
and   an anvil member attached to the at least two flexible
bands of the elongated member and being adapted to form the
plurality of fasteners.
Patent EP-1398219-A2 (EP)
Inventor: DIEHL RALF
IPC: B60R11/00
Filed: 2003-08-21
Abstract: The assembly for installation of electric apparatus (2) in car inside comprises a frame (3), which can be fitted to a fixed car structure and contains a slidable drawer (4) with fixtures (8) for the apparatus Preferably the drawer contains a front wall part (5), one or more lateral wall parts (6), and bottom wall part (7), with at least one wall part (6,7) containing the apparatus fixtures. Typically the bottom wall part has fittings for applying electric supply lines for the apparatus.  Independent claim is included for roof depository in utility vehicle allocated to fixed structure.
Patent EP-1405780-A2 (EP)
Inventor: HOMES GUENTER
IPC: B61D19/00
Filed: 2003-09-10
Abstract: Sliding wall wagon for transporting temperature-sensitive goods by rail comprises a storage chamber (3) surrounded on all sides by heat-insulating walls (4) forming a sandwich construction with foamed material.  Preferred Features: The walls consist of a base panel (6), two end walls (7, 8), two sliding walls (11) on each long side of the loading chamber, and a roof panel (13). The walls consist of inner panels (14) facing the loading chamber and outer panels (15) facing away from the loading chamber. The hollow space (16) arranged between the panels is filled with an insulating foam.
Patent EP-1418725-A2 (EP)
Inventor: CHEN LING TONY
IPC: A63F13/12
Filed: 2003-09-19
Abstract: A condition on a client that is communicating with a server is determined
by issuing a challenge to the client (324), causing the client to produce a response
indicative of the condition (326,328). The server compares the response to an expected
response to determine if the condition is as expected (332), and if not, takes appropriate
action, such as terminating the connection with the client (336).
The server can thus determine if the client is using a modified basic
input output system, modified software, pirated software, or whether other
conditions exist on the client. The challenge can be changed to prevent the client
from returning a false, predetermined response to the challenge. 
     In an application of the invention, the server is employed at a gaming site to provide
the service of enabling players to participate in playing multiplayer games over the Internet.
Patent EP-1405749-A2 (EP)
Inventor: FUJIOKA MASATO
IPC: B60H1/32
Filed: 2003-10-02
Abstract: A vehicle driving system includes a pulley shaft
synchronously rotating with a crankshaft of an engine,
an auxiliary unit drive shaft driving an auxiliary unit,
a planetary gear mechanism portion having elements such
as a sun gear, a pinion carrier and a ring gear. The pulley
shaft and the auxiliary unit drive shaft are adapted for
connection to any two of the elements, respectively. The
motor connecting to the remaining element of the planetary
gear mechanism portion. A lock-up clutch connecting
together the two or more elements of the planetary gear
mechanism portion. A one-way clutch for restricting the
rotation of the auxiliaryunit drive shaft in one direction,
wherein the planetary gear mechanism portion, the motor,
the lock-up clutch, and the auxiliary unit drive shaft
are coaxially disposed in line.
Patent EP-1420209-A2 (EP)
Inventor: TAZAWA MASATO
IPC: H05B3/44
Filed: 2003-11-11
Abstract: It is an object to provide a heating apparatus that uses a
spectral selective type heat radiating material and has improved
safety and energy efficiency, and the present invention is a heating
apparatus that uses a spectral selective type heat radiating
material having a high emissivity in a specific wavelength region,
wherein a film of the spectral selective type heat radiating
material is formed on a surface of a heat radiant while leaving
at least one region of the surface of the heat radiant with nothing
formed thereon, having property capable of identifying whether or
not the heating apparatus is operating and preventing the
temperature of a surface of the heat radiant from rising excessively,
and also is a heating apparatus that uses a spectral selective type
heat radiating material, wherein the spectral selectivity of
spectral emissivity is controlled by adjusting the thickness of
the film of the spectral selective type heat radiating material.
Patent EP-1398231-A2 (EP)
Inventor: MICHENFELDER GEBHARD
IPC: B60S1/08
Filed: 1999-01-08
Abstract: The rain sensor has a measuring section with at  least one light transmitter and at least one cooperating receiver, with propagation of the  light waves between them via the automobile windscreen, so that the output signal provided by the receiver alters when moisture  is deposited on the windscreen, with electronic evaluation  of the  receiver signal. The optical and electronic  components  of the rain  sensor are contained  in a  housing with a cover provided by a light guide body (10).
Patent EP-1431609-A2 (EP)
Inventor: LEHMANN STEFFEN
IPC: F16C3/06
Filed: 2003-12-13
Abstract: The torsion damper (1) for a motor vehicle internal combustion engine crankshaft (4) is made with sheet metal components. The damper has a housing attached to the crankshaft and connected to a flywheel by a sprung coupling. The housing can be a pot shaped sheet metal component with a base and a rectangular cut out in one side.
Patent EP-1398264-A2 (EP)
Inventor: WU CHIN FU
IPC: B62M11/14
Filed: 2003-04-30
Abstract: An improved structure of a gear cluster for a bicycle having a crankset
mounted with a crankshaft provided with a planetary gear module, wherein
the planetary gear module comprises a big wheel and a small wheel section
and the planetary gear module drives an inner gear module mounted onto a
gear plate; one lateral side of the crankshaft is provided with a driving
structure including a second driving wheel and a third driving wheel
engageable with the big and small wheel, and the crankshaft is provided with a
regulating structure for the positioning of the driving structure and the
regulating structure includes two set of a second and a third ratchet block for
the positioning or free rotating of the second and the third driving wheel, and
the regulating structure is provided with a triggering structure to act on
different ratchet block, and the triggering structure makes use of a cable to
provide triggering; thereby a gear shift is obtained so as to provide rapid gear
shifting and to reduce the force used for gear shifting.
Patent EP-1366699-A2 (EP)
Inventor: REINKE CHRISTOPHER
IPC: B65D85/07
Filed: 2003-05-28
Abstract: A flexible sheet container is provided that permits a user to quickly and easily feed a
leading sheet. The container has a base portion that defines a storage area and a top covering
the base portion. The top includes an opening into the storage area through which individual
flexible sheets are dispensed. A pair of opposing flaps is pivotally attached to the top at their
first ends and each extends toward the dispensing opening with its second end. The
complementary second ends of the flaps together further define the dispensing opening while
in a dispensing position. The flaps pivot inward toward the storage area to provide access
through the opening into the storage area. As such, to feed a leading flexible sheet, a user
may rotate the flaps inward, grab a leading flexible sheet, and pull it through the opening.
During dispensing, the flaps rotate outward and retain subsequent sheets.
Patent EP-1420406-A2 (EP)
Inventor: SHINKAI MITSUTOSHI
IPC: G11B27/10
Filed: 2003-11-12
Abstract: A content editing assistance system includes a mark
generator for generating electronic mark data relating to
content data; a take-metadata generator for generating a
take-metadata file based on the electronic mark data
generated for each take; a manager for managing the content
data and the take-metadata file relating to the content data
as separate files; a list generator for generating
electronic-mark-list data based on the take-metadata file;
and an editor for editing the electronic-mark-list data.
Patent EP-1378394-A2 (EP)
Inventor: GUELLICH ARMIN
IPC: B60Q1/48
Filed: 2003-05-16
Abstract: The vehicle (10) may have four proximity sensors (12-15) on its end. The distances (a) between the first and second (b) between the second and third and (c) between the third and fourth are all different. Signals from the sensors are passed to a control circuit (11) with a memory (17) and a calculating circuit (18). The control circuit is connected to an audio-visual alarm (16).
Patent EP-1466019-A2 (EP)
Inventor: KARLSEN FRANK
IPC: C12Q1/6865
Filed: 2003-01-07
Abstract: Oligonucleotide molecules for use in the detection of mRNA transcribed from the E6 gene of a human papillomavirus, the oligonucleotide comprising any one of sequence numbers 1-133. A method of detecting said mRNA by means of NASBA using said oligonucleotides.
Patent EP-1480635-A2 (EP)
Inventor: KRIESEL JOSH
IPC: C07D257/10
Filed: 2003-02-07
Abstract: Macrocyclic module compositions are made from cyclic synthons. The macrocyclic module structures are prepared by stepwise or concerted schemes which couple synthons in a closed ring. The macrocyclic module structures may have a pore of nanometer dimensions.
Patent EP-1546373-A2 (EP)
Title: Methods for measuring rates of reserve cholesterol transport in vivo, as an index of anti-atherogenesis
Inventor: HELLERSTEIN MARC K
IPC: A61K45/00
Filed: 2003-09-15
Abstract: The present invention relates to biochemical methods for determining reverse cholesterol transport. Specifically, the rates of the two arms of reverse cholesterol transport (HDL or first arm and post-HDL or second arm) are obtained by measuring the flow of unlabeled cholesterol from tissues into plasma HDL and from plasma HDL to bile acids.
Patent EP-1524933-A2 (EP)
Inventor: DURAND JEAN-PAUL
IPC: A61B1/12
Filed: 2003-07-29
Abstract: The inventive swab comprises an elastic core (10) and at least one brush (15) arranged thereon. Said brush is provided with an axis (20) and a cleaning twist comprising blades (21) which are regularly disposed on the axis (20). The brushes are moulded from a casting to the core.
Patent EP-1534727-A2 (EP)
Inventor: STORER RICHARD
IPC: C07H19/06
Filed: 2003-08-06
Abstract: Physical forms of beta-L-2'-deoxythymidine are disclosed that can be characterized by physical appearance, purity levels, Infra-Red and Raman spectroscopy, X-ray powder diffraction patterns, thermal properties, and methods of manufacture. These forms of beta-L-2'-deoxythymidine can be used in the manufacture of other forms of beta-L-2'-deoxythymidine, or in pharmaceutical compositions. Particularly preferred uses are in the treatment of hepatitis B.
Patent EP-1540788-A2 (EP)
Inventor: ARNAUD ALAIN
IPC: H02B5/06
Filed: 2003-09-16
Abstract: The isolator has a moving arm (1) in a first plane with its entry terminal (1A) connected to the incoming bus (2A) and its outgoing terminal (1B) connected to the outgoing bus (2B). The bus bars lie in a different plane to the isolator arm. The jaws (5A,5B) on the ends of the bus bars are on opposite sides of the bus bars, and extend between the planes of the bus bars and the isolator arm.
Patent EP-1552538-A2 (EP)
Title: Double-layer capacitor, use of the same, and method for increasing the maximum charges of double-layer capacitor electrodes
Inventor: KIRCHNER EDITH
IPC: H01G9/04
Filed: 2003-10-17
Abstract: A double-layer capacitor includes a first electrode having a first polarity, a second electrode having a second polarity, the first polarity being different from the second polarity, and an electrolyte that is in contact with the first electrode and the second electrode. The first electrode has a first charge of the first polarity and the second electrode has a second charge of the second polarity, and maximum values of the first charge and the second charge are substantially equal.