Patent SG-11201804656P-A (SG)
Title: Antibodies targeting fc receptor-like 5 and methods of use
Inventor: BRENTJENS RENIER
IPC: C07K16/28
Filed: 2016-12-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau ires.. 00) (43) International Publication Date ......../ 8 June 2017 (08.06.2017) WIP0 I PCT (10) WO International 111111111111311111111111111111111111111111111111111111111111111111111111111111111111 2017/096120 Publication Number Al (51) International Patent Classification: NY 10065 (US). EUREKA THERAPEUTICS, INC. C07K 16/28 (2006.01) A61K 47/48 (2006.01) [US/US]; 5858 Horton Street, Suite 362, Emeryville, CA A61K 39/395 (2006.01) 94608 (US). (21) International Application Number: (72) Inventors: BRENTJENS, Renier, J.; 1275 York Avenue, PCT/US2016/064550 New York, NY 10021 (US). SMITH, Eric, L.; 1275 York Avenue, New York, NY 10021 (US). LIU, Cheng; 4 Corn- (22) International Filing Date: modore Drive, #d334, Emeryville, CA 94608 (US). 2 December 2016 (02.12.2016) (74) Agents: KOLE, Lisa, B. et al.; Baker Botts LLP, 30 Rock- (25) Filing Language: English efeller Plaza, New York, NY 10112-4498 (US). (26) Publication Language: English (81) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of national protection available): AE, AG, AL, AM, 62/263,586 4 December 2015 (04.12.2015) US AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (71) Applicants: MEMORIAL SLOAN-KETTERING CAN- DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, CER CENTER [US/US]; 1275 York Avenue, New York, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, [Continued on next page] (54) Title: ANTIBODIES TARGETING FC RECEPTOR-LIKE 5 AND METHODS OF USE (57) : The presently disclosed subject matter mR expression level (REA, lag2) provides fully human antibodies or antigen-binding Tv- as Es 8 r6 0 1 10 100 1000 I I I I fragments thereof that bind to FcRLS and methods of lymphomo_Burkitt lymphama_other 11 - 18 - I I I ---V I V Tonsil EEEEEEEEE Myeloid multiple_myelorno 30 - -- II I- using the same. MEE - E7 lymphomo_DLDCL 18 - I I I : : Monocytes rneningiomo (3 - 11 Dendrite Cells ESE= bile_duct stomach (8 - (38 - SF: o_ - Iv NK Cells MEE I T \" \ IO gell s s 08 44 4 medulloblostoma ( - 0 B Lymphoblasts ende pa ni ne t ri l s P44 : Ill it v 0 B Cells Endothelial EEEEE lungJISC (13 - v-TII-Es 8-cell1d1 n liV v Fetal Brain EE E upper_oemaligestie 3 il -, . Prefrontal Cortex EEE Liver 2 - I 1 i E. Cingulate Cortex EEEEE ovary 5 - ESE. Parietal Lobe EECEEE gliomo esophagus 6 - - :if Es frill Temporal Lobe 7EEEEE breast b reast - : Elyv ‘vs Occipital Lobe EEEE - E7 Ciliary Ganglion EEEEE J Afll-os - V Cerebellum Peduncle SCSR leekemio_ather ( Globus Pallidus EE mesothelioma - iv , v a Olfactory Bulb EEEEEE colorectal 6 {1 1 Nmphomo_Hodgkin if -0 - ill : -i- -2 0 , g Thalamus x x - Si Hypothalamus prostate ( I Subthalamic Nucleus : 6 2 urn i a e ry lan t o rl 1 ir: g Caudate Nucleus s - 11 EvEEEE chondrosorcomo ( - 1E -1 . ?E Amygdalo Pons Ewings_Sarcoma 1 - I SD I X111_1 osteosercorno ' E , s neuroblastoma 1 - - 1H § Medulla Oblogata AML - EV- 'SC r icu r g r 'EEEE grsaRool Ganglion lucell_AL 1 - --U saft_tissue 2 - ED I Trigeminal Ganglion LEEN\ other 1 - I VD: Cardiac Myocytes thyro ell 11: Atrioventricular Node MEER lung_small_c 5 - FIE Tongue. Fetal Liver 7`77:7E CML - v-Tiv Fetal Lung RESEE FIG. 1 FIG. 1 (continued) 0 1 10 100 1000 I I I I 0 1 10 100 1000 I I 1 120 Al 11111111111111111111111 Maj or tissues Bone Marrow = Whole Blood Trachea ESEZE White Blood Cells Bronchial epithelium ESEESE Lymph Node -S Appendix NEER] Thymus Fetal Thyroid 7 SEEE E Brain A1AvAAN E Pancreas islet V E Adrenal Cortex Cortex g- EvLLLCU Cerebellum Prn i et(hli D gli y a EAME Retina rs Pituitary =HE Spinal Cord t i Heart MEM Uterus Corpus 7///// -§ Testis Tubule 7 7 seminif Smooth Muscle Skeletal Muscle .E Testis Germ /AAA A Small Intestine Testis interstitial AAAAA Colon =ES Testis Leydig V ////1 Adipocyte 772 , ..1 Kidney WEI Liver EEEESEI FIG. 1 Lung EEEE1 (continued) Pancreas =M Thyroid EZ= Salivary Gland =Ed Adrenal Gland Breast Skin vtai EEEEEE Ovary Uterus Er/CELT Placenta / A Prostate Testis war C c S FIG. 1 (continued) IN Il C P1 O WO 2017/096120 Al MIDEDIMOMMIONMEMOMMEIH11111111111111111110111111111111 KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every with international search report (Art. 21(3)) kind of regional protection available): ARIPO (BW, GH, — before the expiration of the time limit for amending the GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of