Patent SG-11201408395W-A (SG)
Title: Substituted pyridine azolopyrimidine - 5 - (6h) - one compounds
Inventor: ALLAN AMY
IPC: A61P25/00
Filed: 2013-06-18
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 December 2013 (27.12.2013) WIPOIPCT (10) International Publication Number WO 2013/192229 A1 (51) International Patent Classification: C07D 487/14 (2006.01) A61P 25/00 (2006.01) A61K31/519 (2006.01) A61P 9/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/046415 18 June 2013 (18.06.2013) English English (30) Priority Data: 61/661,091 18 June 2012 (18.06.2012) US (71) Applicant: DART NEUROSCIENCE (CAYMAN) LTD; 4th Floor, Queensgate House, 113 South Church Street, P.O. Box 1994, Grand Cayman, KYI 1104 (KY). (72) Inventors: ALLAN, Amy; 542 San Dieguito Drive, Encin- itas, CA 92024 (US). BRANSTETTER, Bryan; 4747 Marina Dr. #3, Carlsbad, CA 92008 (US). DYCK, Brian; 9242 Pebblestone Lane, San Diego, CA 92126 (US). WEINHOUSE, Michael, I.; 3215 Purer Rd„ Escondido, CA 92029 (US). GOMEZ, Laurent; 13270 Russet Leaf Lane, San Diego, CA 92129 (US). MARRONE, Tammi. Jo; 6420 Ruby Way, Carlsbad, CA 92011 (US). PETERS, Marco; 4567 Louisiana Street, San Diego, CA 92116 (US). (74) Agent: MILLER, Kimberly, J.; Knobbe Martens Olson & Bear LLP, 2040 Main Street, 14th Floor, Irvine, CA 92614 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, [Continued on next page] (54) Title: SUBSTITUTED PYRIDINE AZOLOPYRIMIDINE - 5 - (6H) ONE COMPOUNDS - 0\ CJ CJ CJ o\ FIG. 1 (57) Abstract: Described herein are compounds and chemical entities of Formula I, methods of their syn­ thesis, compositions comprising them, and their use in treating numerous diseases and disorders, includ­ ing cognitive deficits associated with CNS diseases and disorders i-H o CJ o & WO 2013/192229 Al I lllll llllllll II llllll III lllll lllll III III III lllll lllll lllll lllll lllll llll lllllll llll llll llll EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with international search report (Art. 21(3))