Patent SG-11201803915U-A (SG)
Title: Echinomycin formulation, method of making and method of use thereof
Inventor: LIU YANG
IPC: A61K38/12
Filed: 2016-11-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property - Organization International Bureau rist0) ..... ..ol (43) International Publication Date rr eso 18 May 2017 (18.05.2017) WIPO I PCT (10) WO International Publication Number 111111111111311111111111111111111111111111111111111111111111111111111311111111111111111 2017/083403 Al (51) International Patent Classification: (74) Agent: YE, Michael; Andrews Kurth Kenyon LLP, 1350 I A61K 9/127 (2006.01) A61K 38/08 (2006.01) Street, N.W. Suite 1100, Washington, DC 20005 (US). A61K 31/395 (2006.01) A61K 38/12 (2006.01) A61K 35/74 (2015.01) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, PCT/US2016/061157 BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 9 November 2016 (09.11.2016) KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (25) Filing Language: English MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (30) Priority Data: TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, 62/253,257 10 November 2015 (10.11.2015) US ZW. Designated States indicated, (71) Applicant: CHILDREN'S RESEARCH INSTITUTE, (84) (unless otherwise for every kind ARIPO GH, CHILDREN'S NATIONAL MEDICAL CENTER of regional protection available): (BW, [US/US]; 111 Michigan Ave., NW, Washington, DC GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 20010 (US). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (72) Inventors: LIU, Yang; 502 E Street, NW, Washington, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, DC 20002 (US). WANG, Yin; 2525 Ralph Ellison Way, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, NE, Washington, DC 20018 (US). LIU, Yan; 2525 Ralph SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Ellison Way, NE, Washington, DC 20018 BAILEY, (US). GW, KM, ML, MR, NE, SN, TD, TG). Christopher; 290 McGill Lane, Merritt Island, FL 32953 Published: (US). ZHENG, Pan; 502 E St., NE, Washington, DC 20002 (US). — with international search report (Art 21(3)) (54) Title: ECHINOMYCIN FORMULATION, METHOD OF MAKING AND METHOD OF USE THEREOF 'goo 80 - To . z .-, ' 60 - L = —Vehicle co 40 -.. 0 —Lipo-EM 20 —PBS-EM 1-1 .4t M 0 en M cc O it-- 1-1 (57) : A liposomal drug formulation for O HIF-2a includes a plurality of liposomes in a pharmaceutically \" made from a peglyated phospholipid, a neutral phosphoglyceride, Q erative diseases, leukemia, cancer, autoimmune diseases 0 0 30 60 90 Days FIG - RE 4 treating a disease in a patient characterized by overexpression of HIF-1a and/or acceptable carrier. The liposomes encapsulate echinomycin and are and a sterol. The PEGylated liposomes may be used to treat prolif - and graft-versus-host disease.