baber/WOPTO huggingface dataset:
Patent EP-0289227-B1 (EP)
IPC: C07D233/64
Filed: 1988-04-22
Granted: 1992-04-08
Abstract: Substituted imidazolyl-alkyl-piperazine and diazepine derivatives of Formula A: <CHEM>  wherein:      R<1> is aryl;      R<2> is aryl, C1-4 alkyl, or hydrogen;      R<3> is C1-4 alkyl, hydroxy, or hydrogen;      R<4> is aryl;      R<5> is aryl;      m is two or three;      n is zero, one or two,  provided that when R<3> is hydroxy, n is one or two; and      q is zero, one, two, or three; and the pharmaceutically acceptable salts thereof, are useful for treating mammals having a variety of disease states, such as stroke, epilepsy or epileptic psychotic symptoms, hypertension, angina, migraine, arrhythmia, thrombosis, embolism, acute cardiac failure, irritable bowel syndrome, neurodegenerative diseases such as Alzheimer's or Huntington's chorea, diuresis, ischemia such as focal and global ischemia or cerebrovascular ischemia induced by cocaine abuse, and also for treatment of spinal injuries.
Patent EP-0288347-B1 (EP)
IPC: B65D69/00
Filed: 1988-03-24
Granted: 1991-08-28
Abstract: Package for liquid detergents comprising, in combination: a) a jerry can equipped with a removable stopper (4) and preferably designed to contain a metered amount of detergent, an opening being provided through the jerry can,     b) a metering and dispensing device which can be housed in the said opening, interacting with the periphery thereof, the said device consisting of a body (9) made from flexible material and having the shape of a bellows, and dispensing means integral with the body (9) and having orifices;     c) holding means (16) ensuring that, when the device is in position, the dispensing means pass through the opening of the jerry can whilst the bellows is held in the folded state in the vicinity of the opening, the device then being substantially inserted into the thickness of the jerry can. The device may be separated from the jerry can in order to be filled with detergent and placed in the drum of the laundry-washing machine.   <IMAGE>
Patent EP-0308328-B1 (EP)
Title: (benzyl-piperidino)-1-propanol-2 derivatives, their preparation, their use as microbicides and compositions containing them
IPC: C07D211/14
Filed: 1988-09-15
Granted: 1991-12-04
Abstract: Compounds of formula: 
<IMAGE>
 in which:
 - Ar denotes a phenyl group substituted by R2, R3 and R4 or a 1-naphthyl or 2-naphthyl group, unsubstituted or substituted by 1 or 2 halogen atoms;
 - X denotes an oxygen atom or a sulphur atom;
 - R1 denotes H or a halogen atom;
 - R2 denotes a halogen atom, a trifluoromethyl group, a phenyl group unsubstituted or substituted by 1 to 3 halogen atoms, a benzyl group unsubstituted or substituted by 1 to 3 halogen atoms, a phenoxy group unsubstituted or substituted by 1 to 3 halogen atoms or a C1-C4 alkyl group;
 - R3 and R4 denote H, a halogen atom or a C1-C4 alkyl group;
 - the benzyl group substitutes the piperidino radical in position 2, 3 or 4;
 and their salts with inorganic or organic acids. 
<??>The invention also relates to a process for the preparation of the said compounds and to their use as antimicrobial agents, as antiseptics, disinfectants, stabilisers in various types of products (pharmaceutical compositions, cosmetic products, alimentary products etc.). It also relates to the said products containing the compounds of formula (I).
Patent EP-0333969-B1 (EP)
Title: Container for loose products in general, provided with raising means, adapted to be stored either in a horizontal or in a vertical position
IPC: B65D88/16
Filed: 1988-05-19
Granted: 1992-12-23
Abstract: The present invention relates to a container (1) for loose products in general, provided with raising means, adapted to be stored either in a horizontal or in a vertical position, comprising a holding body (2) of elongated parallelepipedal shape, made of a high strength fabric and provided, on its opposite bases, with respectively a discharging outlet (4) and a loading inlet (3). At one of the bases, there are provided strips (10) for vertically raising the container whereas, at the middle region of the side surface, there are provided holding straps (11) which are arranged at ring members (12), which straps can be used for raising horizontally the container.
Patent EP-0295312-B1 (EP)
Inventor: KIOKA MAMORU
IPC: C08F210/16
Filed: 1987-12-28
Granted: 1994-04-20
Abstract: This solid catalyst for olefin polymerisation comprises a cpd. of a group IVB transition metal, aluminoxane, and fine particles of an organic or inorganic carrier, 100 g of the fine particle carrier carries 0.5-500 mg metal atom in the transition metal compd. and 5-50,000 mg of aluminium atom in the aluminoxane. The atomic ratio (A1/M) of the aluminium metal to the transition metal lies between 1 and 1,000 (preferred 20 and 500). The mean particle size of the catalyst lies between 5 and 200 um (preferred 10 and 100 um). The transition metal is specified to be Zr, Ti or Hf. The compd. containing the transition metal is represented by the formula (I) where R1 is cycloalkadienyl group; R2, R3 and R4 are independently cycloalkadienyl, aryl, alkyl, cycloalkyl, aralkylgroup, halogen atm, hydrogen atom, ORa, SRb, NRc or PRd, (where Ra, Rb, Rc and Rd are independently alkyl, cycloalkyl, aryl or aralkyl group; two Rcs and two Rds can combine together to form rings); when R2 is cycloalkadienyl, R1 and R2 can combine through a lower carbon number alkylene group; k = 1, 2, 3 or 4; l, m and n are independently 0, 1, 2, 3 ; k + l + m + n = 4. Aluminoxane is represented by the general formulae (II), (III), where R is hydrocarbon gp. or halogen at hydrocarbon group; m at least 2. The catalyst is prepared by deposition and emulsion of the emulsive solutions of aluminooxane, and the transition metal compd. with carrier particles.
Patent EP-0304462-B1 (EP)
Title: Apparatus for optical wavelength division multiplexing
IPC: H01S3/08
Filed: 1988-03-11
Granted: 1992-06-17
Abstract: Apparatus (Fig. 2) of the type comprising an optical assembly (9), e.g. a lens (11) and reflection grating (13), for collimating light emitted by a laser (L1'), and for refocussing the same onto an output waveguide (7). The waveguide (7) is modified to enhance reflection of the refocussed light, which in turn dominates the resonant response of the laser (L1'). Laser resonance thus depends on geometrical factors, the relative positions of laser (L1') and waveguide (7) and the dispersion properties of the assembly (9). Wavelength selectivity is improved by confining reflection to the core of the waveguide (7) e.g. by using an embedded reflector (17), or further still by using an etalon pair (17, 17'). The laser (L1') may be used in conjunction with other lasers (Ln') and/or detectors, or with retroreflectors (27). A multi-laser input multiplexer (Fig. 2) and single channel drop-and-add devices (Fig. 7; Fig. 10) are described.
Patent EP-0309560-B1 (EP)
Inventor: DATEMA ROELF
IPC: C07H19/06
Filed: 1988-04-06
Granted: 1994-12-21
Abstract: A compound of formula (I), wherein the radicals A, X, R1, R2, and R3 are defined as follows: A: formula (a) or formula (b); X: (a) O; (b) S; (c) CH2; R1: H; alkyl containing 1-3 carbon atoms; -CH=CH2; -CH=CH-CH3; -CH2-CH=CH2; formula (II); -C=CH; R2: H; or R2 constitutes together with R3 a carbon-carbon bond; R3: H; F; Cl; Br; I; N3; CN; C=CH; OH; OCH3; CH2OH; and when R3 is F; Cl; Br; I; N3; CN; C=CH; OH; OCH3 or CH2OH it may have either the cis-configuration or trans-configuration relative to the hydroxymethyl function at position 4', or R3 constitutes together with R2 a carbon-carbon bond, and therapeutically acceptable salts thereof, for use in therapy, in particular for the treatment of HIV virus infections.
Patent EP-0415920-B1 (EP)
Title: Anticorps monoclonal specifique aux antigenes de l'hiv
Inventor: KORTRIGHT KENNETH H
IPC: C12R1/91
Filed: 1988-06-10
Granted: 1995-09-20
Abstract: La lignée de cellules hybrides décrite a le pouvoir de produire des anticorps monoclonaux qui se lient à l'antigène P55 du noyau de l'HIV (virus d'immuno-déficience humain), à la protéine précurseur codée pour le gène de bâillonnement, à la protéine de noyau P24 et à des produits de rupture partielle de types P39 et P33. L'anticorps monoclonal de la présente invention ne se lie pas à la protéine de noyau P18 ou aux antigènes de l'enveloppe de l'HIV. La lignée cellulaire de la présente invention a été mise au point par un protocole d'immunisation unique, dans lequel des souris de type BALB/c ont été immunisées au cours d'une série de plusieurs injections utilisant un groupe choisi d'immunogènes et une lignée de cellules de myélome traditionnelle pour leur fusion avec les splénocytes murins cultivés. Ledit anticorps monoclonal est identifié comme l'anticorps KC-57. Cet anticorps monoclonal est particulièrement utile pour une immuno-analyse en phase solide, dans laquelle l'anticorps monoclonal est détecté dans sa liaison aux antigènes de l'HIV se trouvant dans un échantillon de sérum ou de plasma d'un sujet humain. La lignée cellulaire qui produit l'anticorps monoclonal KC-57 a été enregistrée auprès de l''American Type Culture Collection'', à Rockville dans le Maryland et a reçu par l'A.T.C.C. le numéro HB 9585.
Patent EP-0339620-B1 (EP)
Title: Method for making stop cross tapes on slide fasteners
IPC: A44B19/36
Filed: 1989-04-26
Granted: 1993-03-17
Abstract: The invention relates to a method for making stop cross tapes of textile fabrics with or without coating(s) from plastics or elastomers on one or both sides of end connections of slide fasteners. The essential factor of this invention is that the stop cross tapes are formed in each case by incision into the coated or uncoated fabric panel (1) which constitutes the end connection or its reinforcement; folding the panel strips (3a, b), which were produced by incision on the side of the fabric panel (1) facing the slide fastener chain, in a direction which is rotated in each case by 90 DEG  relative to its original positions; and attaching the panel strips (3a, b), thus folded, parallel to the slide fastener chain directly next to the tape fold (10) on the side, opposite the slide fastener chain, of the two backing tapes (8a, b) of the slide fastener. <IMAGE>
Patent EP-0362718-B1 (EP)
Title: Grid bar for sectional false floors
IPC: E04F15/024
Filed: 1989-09-29
Granted: 1992-02-26
Abstract: It is known to lay out the floorboards of raised floors on grid girders, which are attached to the cover plates of legs of the raised floor. The grid girders are either inserted into suitable recesses in the cover plates where they may be made secure in these recesses by means of tongues which engage in boreholes in the cover plates, or else under more stringent specifications they are screwed into the reinforcement of the raised floor with the cover plates. Until this time, for the two variations of assembly, two different types of girders have also been produced. Both variations of assembly can be attained by use of the grid girder according to the present invention. For this purpose, the side walls of the grid girder are provided with beveled ends in such a manner that the grid girder, when viewed from the side, has the shape of a parallelogram. At the ends of both of the other walls of the grid girder are provided in turn tongues or oblong apertures for the passage of fastening screws. Tongues are intended for the loose engagement of the grid girder in the boreholes of cover plates, while with the other variation of assembly the fastening screws are fed through oblong apertures and are twisted or tapped into the boreholes.
Patent EP-0362961-B1 (EP)
Inventor: TACK MARNIX ROGER ANNA
IPC: H01L29/66
Filed: 1989-10-03
Granted: 1994-02-16
Abstract: A SOI-nMOS-structure is cooled such that a charge is maintained in a cavity (5) of such structure for a long period of time. Applications comprise memory element.
Patent EP-0350172-B1 (EP)
Title: Process for preparing an aminomethylphosphonic chelating resin
IPC: C08F8/40
Filed: 1989-06-15
Granted: 1993-06-23
Abstract: Aminomethylphosphonic chelating resins are prepared by amination, hydrolysis and methylphosphonation of haloalkylated polymer beads. The amination of the haloalkylated polymer beads is carried out with hexamethylenetetramine. The produced haloaminated beads are hydrolysed and methylphosphonated in one step without addition of a substantial amount of formaldehyde or a formaldehyde-releasing compound.
Patent EP-0357306-B1 (EP)
Inventor: PARODOS KYRIAKI
IPC: C12Q1/689
Filed: 1989-08-18
Granted: 1995-03-01
Abstract: Nucleic acid probes capable of specifically hybridizing to rRNA of E. coli and Shigella species and not to rRNA of non-E. coli/Shigella are described along with methods utilizing such probes for the specific detection of E. coli and/or Shigella in food and other samples.
Patent EP-0373836-B1 (EP)
Inventor: FOSTER BENNIE JOE
IPC: C07D333/34
Filed: 1989-12-08
Granted: 1994-03-16
Abstract: The present invention provides propanamines, substituted at the 3-position of the propanamine chain with a thio, sulfinyl or sulfonyl moiety, of the formula <CHEM>  wherein: R is phenyl, substituted phenyl, naphthyl, substituted naphthyl, thienyl, halothienyl, (C1-C4 alkyl)-substituted-thienyl, furanyl, halofuranyl, (C1-C4 alkyl)-substituted-furanyl, pyrrolyl, halopyrrolyl or (C1-C4 alkyl)-substituted-pyrrolyl; R<1> is phenyl, substituted phenyl, C5-C7 cycloalkyl, thienyl, halothienyl, (C1-C4 alkyl)-substituted-thienyl, furanyl, pyridyl or thiazolyl;  R<2> and R<3> are each independently hydrogen or methyl;  n is 0, 1 or 2; and  the pharmaceutically acceptable acid addition salts thereof. They are capable of selectively inhibiting the uptake of serotonin and norepinephrine.
Patent EP-0393104-B1 (EP)
IPC: A61K49/00
Filed: 1988-11-30
Granted: 1992-07-15
Abstract: La présente invention se rapporte à un procédé servant (1) à évaluer l'activité de la maladie chez des patients souffrant d'affections intestinales chroniques de type inflammatoire (IBD), à savoir de colites ulcéreuses (UC) et de colites de Crohn (CC) respectivement, et (2) à prévoir (a) le résultat d'un traitement médical dans le cas d'affections actives graves, dans lesquelles une chirurgie aiguë ou subaiguë peut constituer une autre solution, en plus (b) du risque de rechute chez des patients sans symptômes, qui veulent arrêter de prendre des médicaments destinés à empêcher la rechute. La présente invention se rapporte en outre à un kit destiné à être utilisé dans le procédé décrit ci-dessus. Le kit test comprend des sacs de dialyse conçus pour une administration orale et/ou une introduction rectale, en plus de substances test essentielles et spécifiques servant à la détermination radio-immunologique de la présence de PGE2 dans le contenu des sacs de dialyse.
Patent EP-0362304-B1 (EP)
Inventor: BLACKBURN GARY F
IPC: G01N33/544
Filed: 1988-12-12
Granted: 1997-03-05
Abstract: A sensor for the analysis of physical and chemical changes in a test solution includes a glass tube (10) with an end covered by a membrane. The glass tube contains an internal Ag/AgCl electrode (24) in solution (22). The membrane (14) is a dialysis membrane which allows ions to pass through and contact an antibody immobilized on a spacer material (12). This spacer material (12) is placed between the dialysis membrane (14) and a glass membrane (16), thereby forming a sensing area (18).
Patent EP-0370080-B1 (EP)
Title: Dispositif electrohydraulique de regulation de pression
IPC: B60T8/32
Filed: 1989-03-20
Granted: 1992-07-22
Abstract: Dispositif électrohydraulique de régulation de pression pour un système de réglage antiblocage. Il s'agit d'un agrégat monobloc comprenant un régulateur électronique (1) et une unité hydraulique. Cette dernière comprend un corps de logement (18) pour des soupapes électromagnétiques et un couvercle (13). Ce dernier contient les bobines (5, 6) dépassant du corps de logement de soupapes. Ledit régulateur (1) et l'unité hydraulique sont reliés par un dispositif de montage, de positionnement et d'ancrage (3) et par un dispositif de contact électrique (4). Ledit dispositif d'ancrage (3) est agencé à proximité du corps de logement de soupapes (18). Ledit dispositif de contact électrique (4) est agencé entre le couvercle (13) et le régulateur électronique (1). Ledit dispositif d'ancrage (3) intercepte les forces extérieures qui s'exercent sur le régulateur (1). Ledit dispositif de contact (4) sert à produire un contact électrique protégé et sans danger. Ladite invention porte également sur un agrégat de bloc de valves pour un dispositif de réglage antiblocage. Ledit agrégat contient plusieurs soupapes électromagnétiques réunies en un seul bloc et agencées dans un corps de logement de soupapes. Lesdites bobines des soupapes électromagnétiques dépassent du corps de logement de soupapes et sont munies d'éléments de contact. Ledit agrégat de bloc de soupapes comprend un couvercle qui protège les parties des bobines qui dépassent ainsi que les éléments de contact. Ledit couvercle est conçu comme un régulateur électronique et constitue avec l'agrégat de bloc de soupapes un élément solidaire.
Patent EP-0396665-B1 (EP)
Inventor: PEACOCK DAVID JOHN HOWARD
IPC: G01L3/24
Filed: 1989-09-19
Granted: 1993-11-18
Abstract: The apparatus for measuring the comparative output power of each cylinder of a multi-cylinder engine comprises a digital signal processor (1) and a phase locked loop detector (2). By inputting instantaneous current measurements from (e.g.) a current transformer attached to an alternator output of an engine under test and analysing same in the processor (1), instantaneous engine speed may be measured. This measurement may be processed to determine comparative measurements of compression and power output of each of the cylinders.
Patent EP-0387527-B1 (EP)
Title: Process for the fermentative production of L-lysine
Inventor: BACHMANN BERND DR
IPC: C07H21/04
Filed: 1990-02-12
Granted: 1994-06-22
Abstract: A process for the preparation of L-lysine in which recombinant DNA which consists of a DNA fragment which has a genetic sequence coding for the production of proteins which lead to an aspartyl- beta -semialdehyde dehydrogenase (asd) activity or to the deregulation of aspartate kinase (lysC), which sequence derives from a microorganism of the genus Corynebacterium or Brevibacterium, and of vector DNA is inserted into a microorganism of the genus Corynebacterium or Brevibacterium, the transformants obtained in this way are cultured in a suitable medium, and the L-lysine which is produced is separated therefrom, is described.
Patent EP-0410228-B1 (EP)
Inventor: COSMINA PAOLA
IPC: C12N15/73
Filed: 1990-07-13
Granted: 1994-06-15
Abstract: The regulation of the expression of heterologous gene which codes for a protein of interest in B.subtilis is achieved by the introduction into the microorganism of a plasmid vector containing the gene placed under the control of a strong promoter whose activity is modulated by means of a variation in the temperature by the heat-sensitive repressor of the lambda phage of E.coli. The method enables various heterologous proteins to be synthesised by the culture of strains of B.subtilis with transformations induced by variations in temperature.
Patent EP-0415306-B1 (EP)
Inventor: DUBUIS ROBERT
IPC: B01D53/86
Filed: 1990-08-27
Granted: 1994-12-07
Abstract: The apparatus for the reduction of nitrogen oxide compounds present in combustion gases originating from a combustion chamber comprises, on the main trajectory (20) for removing the gases, means (14) for blowing and means (16) for heating the combustion gases carrying the reducing agent. A secondary trajectory (28) is connected in parallel to the main trajectory (20) for reintroducing the combustion gases leaving the catalyst (18) downstream of the means (24) for injection. The secondary trajectory (28) comprises a valve (32) which can be actuated in response to a command signal representative of the state of operation of the burner (4) to permit a closed-circuit circulation of the gases between a point (38) situated downstream of the means for injection and a point (40) situated upstream of the trajectory (6) for removal of the gases in the absence of combustion gas at the exit of the chamber. <IMAGE>
Patent EP-0416466-B1 (EP)
Inventor: SAWADA TAKASHI
IPC: G01N33/569
Filed: 1990-08-30
Granted: 1995-03-08
Abstract: The assay method comprises the steps of adding a serum specimen to a solid phase at a pH value of 9 to 10 and assaying an antibody in the specimen. The antibody may be adult T cell leukemia virus antibody (HTLV-I antibody).
Patent EP-0431703-B1 (EP)
Inventor: BOUTANG JEROME JEAN-M
IPC: A23L19/00
Filed: 1990-12-04
Granted: 1997-03-05
Abstract: Fruit material is air-dried at material temperatures not exceeding 50 DEG C and preferably not exceeding 40 DEG C until 20 to 60% of its initial weight is evaporated and thereafter exposed to an aqueous medium containing one or more sugars and then preferably frozen. Fruit material, in particular frozen, having 40 to 80% of its original weight and containing some added sugar, preferably mono saccharide.
Patent EP-0381447-B1 (EP)
Inventor: HETHERINGTON RICKY C
IPC: G06F12/08
Filed: 1990-01-30
Granted: 1997-08-06
Abstract: In the field of high speed computers it is common for a central processing unit to reference memory locations via a virtual addressing scheme, rather than by the actual physical memory addresses. In a multi-tasking environment, this virtual addressing scheme reduces the possibility of different programs accessing the same physical memory location. Thus, to maintain computer processing speed, a high speed translation buffer 30 is employed to perform the necessary virtual-to-physical conversions for memory reference instructions. A translation buffer fixup unit 52 is employed to update the translation buffer 30 with the most recently accessed physical memory locations. Therefore, subsequent virtual memory references to these same locations are quickly processed without reference to the much slower main memory 14. The translation buffer fixup unit 52 consists of a state machine 66 controlling hardware specifically designed for the purpose of updating the translation buffer 30. These translation buffer updates are performed immediately after a "miss" is detected by stalling the translation buffer 30 to prevent subsequent conversions until the update is completed.
Patent EP-0420397-B1 (EP)
Inventor: IWAMOTO OSAMU
IPC: G03C1/73
Filed: 1990-07-23
Granted: 1995-11-29
Abstract: A fulgimide derivative of the formula: <CHEM> wherein R<1>, R<2>, R<3> are independently alkyl, cycloalkyl, aryl, etc.; R<4> is thienyl, indolyl, furyl, etc.; X is a divalent organic residue; and R is amino, OH, etc., or a vinyl group, has a photochromic action and can be used for producing photochromic polymers and copolymers.
Patent EP-0425225-B1 (EP)
Inventor: MOSSE RICHARD WOLFGANG EMIL
IPC: B31B5/80
Filed: 1990-10-22
Granted: 1993-12-29
Abstract: The device comprises at least two stations for the erecting of blanks positioned sequentially along a conveyor member for conveying a succession of blanks to the stations. A carton blank erector in each station is operable in use initially to lift a blank from the conveyor member and subsequently to erect the blank. The carbon blank erector comprises a suction head (14) for attachment by suction to a blank (12) in use and elements for moving the suction head through a cycle of movement from a blank collection position, through a blank lifting phase, then through a blank erecting phase in which the blank is pressed against an abutment member (50) to force the blank to an erected condition. When the suction head reaches a blank releasing position the blank is released, held between abutment member (50) and a second abutment member (56), and the suction head is returned. The suction heads are carried by a link arm (20) driven in a parallel movement by cams (30, 32) via pivot arms (22, 24).