Patent SG-11201901249Y-A (SG)
Title: Aza-indazole compounds for use in tendon and/or ligament injuries
Inventor: BURSULAYA BADRY
IPC: C07D471/04
Filed: 2017-09-21
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 29 March 2018 (29.03.2018) WIPO I PCT 0111111010 0111 °nolo III um VIII O II oimIE (10) International Publication Number WO 2018/055551 Al (51) International Patent Classification: CO7D 471/04 (2006.01) A61P 19/02 (2006.01) A61K 31/437 (2006.01) (21) International Application Number: PCT/IB2017/055737 (22) International Filing Date: 21 September 2017 (21.09.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/398,865 23 September 2016 (23.09.2016) US (71) Applicant: NOVARTIS AG [CH/CH]; Lichtstrasse 35, 4056 Basel (CH). (72) Inventors: BURSULAYA, Badry; Novartis Institute for Functional Genomics, Inc., dba, Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121 (US). FISCH, Andreas; No- vartis Pharma AG, Postfach, 4002 Basel (CH). LAJINESS, James Paul; Novartis Institute for Functional Genomics, Inc., dba, Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121 (US). MACHAUER, Rainer; Novartis Pharma AG, NIBR Klybeck, Postfach, 4002 Basel (CH). MALEKAR, Swapnil; Novartis Institutes for BioMedical Research, Inc., Emeryville Site 5300 Chiron Way, Bldg. 4, Emeryville, CA 94608 (US). PETRASSI, Hank Michael James; 4695 Ser- enata Place, San Diego, CA 92130 (US). RAMAZANI, Farshad; Novartis Pharma AG, Postfach, 4002 Basel (CH). REMOND, Anne-Catherine; Novartis Pharma AG, No- vartis Institutes for Biomed. Research, Postfach, 4002 Basel (CH). ULLRICH, Thomas; Novartis Pharma AG, Novartis Institutes for Biomed. Research, Postfach, 4002 Basel (CH). USSELMANN, Peggy; Novartis Pharma AG, Novartis In- stitutes for Biomed. Research, Postfach, 4002 Basel (CH). VANGREVELINGHE, Eric; Novartis Pharma AG, No- vartis Institutes for Biomed. Research, Postfach, 4002 Basel (CH). (74) Agent: NOVARTIS AG; Lichtstrasse 35, 4056 Basel (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) W O 20 18/05555 1 Al (54) Title: AZA-INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES (57) : The present invention provides a compound of formula (I) in free form or in pharma- ceutically acceptable salt form, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition. (I)