baber/WOPTO huggingface dataset:
Patent CA-2391711-A1 (CA)
Title: Non-radioactive assay of lipopolysaccharide kinases
Inventor: LAM JOSEPH
IPC: C12Q1/48
Filed: 2002-06-26
Abstract: The present invention involves a method of assaying for modulators of enzymes involved in the phosphorylation of the inner core oligosaccharide of LPS. In particular, the method assays for modulators, preferably inhibitors, of WaaP, a tyrosine kinase responsible for the phosphorylation of HepI of the inner core LPS. The finding that monoclonal antibody mAb 7-4 specifically recognizes the phosphate group(s) of LPS, is the basis for the development of a non-radiolabeling, ELISA-based assay for enzymes involved in the phosphorylation of LPS.
Patent CA-2392171-A1 (CA)
Inventor: GARDENER LAURIE
IPC: H01M50/166
Filed: 2001-01-15
Abstract: La présente invention concerne un ensemble (10) comportant un bac d'accumulateur (11) et un couvercle (12). Le couvercle (12) définit un caisson (13) pour la réception d'une fermeture auxiliaire (14), le caisson permettant un accès de remplissage au bac d'accumulateur (11). On applique la fermeture auxiliaire au bac d'accumulateur au moyen d'un appareil de fermeture auxiliaire. Celui-ci comporte essentiellement trois unités: un ensemble de logement de couvercle et de bac d'accumulateur (16), un unité de platine réchauffée (17) et un applicateur de fermeture (18). Par la prise avec le couvercle (12), plutôt qu'avec le bac (11), on élimine sensiblement tout décalage de position du couvercle par rapport au caisson. On effectue l'orientation de la platine et de la fermeture (14) suite à la détection de la position du coffre (13) et/ou du couvercle (12).
Patent CA-2392438-A1 (CA)
Inventor: BARASH STEVEN C
IPC: C12Q1/68
Filed: 2001-01-17
Abstract: The present invention relates to novel pancreatic cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "pancreatic cancer antigens", and the use of such pancreatic cancer antigens for detecting disorders of the pancreas, particularly the presence of pancreatic cancer and pancreatic cancer metastases. More specifically, isolated pancreatic cancer associated nucleic acid molecules are provided encoding novel pancreatic cancer associated polypeptides. Novel pancreatic cancer polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human pancreatic cancer associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the pancreas, including pancreatic cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
Patent CA-2394015-A1 (CA)
Title: Tweak receptor
Inventor: WILEY STEVEN R
IPC: A61P9/10
Filed: 2000-12-19
Abstract: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.
Patent CA-2395650-A1 (CA)
Title: Appliances
Inventor: KNODLE DANIEL W
IPC: H04N21/462
Filed: 2000-04-04
Abstract: Appliances (20) designed to be mounted on the bottom (54, 56) of a structure such as an overhead cabinet system (37). The appliance has an integrated unit (22) (or module) which includes a television tuner (140) and, optionally, a player (142) for an optically readable disk (144). The appliance (20) also has a display unit (24) of the flat screen type. The display unit (24) is attached to the appliance module (22) by a universal pivot mechanism (248) which allows the unit (24) to be: (a) rotated and tilted to face a viewer, and (b) folded up against the appliance module (22) and out of the way when the display (24) unit is not in use.
Patent CA-2402608-A1 (CA)
Inventor: SCHMIDT KRISTINA
IPC: G01N21/552
Filed: 2001-02-16
Abstract: The invention relates to an an SPR surface plasmon resonance spectroscopy sensor for parallel measurement of a plurality of samples, comprising a body (1a) having several SPR sensor areas (2) for guiding radiation in order to carry out SPR measurements and which are coated with a material which is suitable for SPR in such a way that each SPR sensor area (2) can be exclusively associated with a single sample. The radiation conducting body (1a) forms a unit with the SPR sensor areas (2), whereby the path of the rays guided by the SPR sensor areas (2) can also extend through the radiation conducting body (1a).
Patent CA-2403026-A1 (CA)
Title: Process for the preparation of 6-o-propargyl erythromycin derivatives
Inventor: KERDESKY FRANCIS A J
IPC: C07D409/04
Filed: 2001-03-20
Abstract: Disclosed herein is a process for the preparation of erythromycin derivatives, or pharmaceutically acceptable salts thereof, which contain an optionally substituted propargyl group at the 6-O-position.
Patent CA-2403150-A1 (CA)
Title: Process and apparatus for the production of a detergent bar
Inventor: STOCKER FREDERICK EDMUND
IPC: C11D13/16
Filed: 2001-03-29
Abstract: In an apparatus and process for manufacturing a detergent bar, the bar comprises a first distinct zone comprising a first component and at least a second distinct zone comprising a second component.  In an injection step, the first and second components are injected into the mould cavity via nozzle means having a first orifice through which the first component is injected. The second component is injected through a second orifice of the nozzle means. The first and second components solidify in the cavity to form the bar. The interface between the zones may be non-planar and/or such that the zones cannot be separated by a unidirectional cut.  The first and second zones may respectively comprise detergent and a benefit agent. The first and second zones may differ in texture.
Patent CA-2403158-A1 (CA)
Title: An aircraft with a detachable passenger escape cabin and an aircraft with airbags
Inventor: GIANNAKOPOULOS PAVLOS
IPC: B64C1/32
Filed: 2000-11-23
Abstract: An aircraft with a detachable cabin (1) that serves to rescue its passengers as a result of the aircraft's sudden fall either due to its malfunction or fire. The cabin escapes either smoothly or by means of fast ejection and descends slowly to the Earth with the aid of a parachute (13;  14); during a crash on the ground or in the sea external airbags (38a-38f) with which it is equipped and which are located in its lower part are inflated thus absorbing the loads that are developed during the crash. In addition a conventional aircraft (70) of the type being already in use is also described and in which the parachute equipment (71) has already been applied; however, the proposed equipment of the airbag boxes (72a-72c) is adapted to it for the absorption of the energy produced due to its crash on Earth in case of its sudden fall.
Patent CA-2404222-A1 (CA)
Title: Application of wavefront sensor to lenses capable of post-fabrication power modification
Inventor: MALONEY ROBERT
IPC: G02B27/00
Filed: 2001-03-20
Abstract: The present invention relates to methods of implementing an optical element having a refraction modulating com-position. The methods include using a wavefront sensor to provide an optical measurement of the optical element. The present invention also relates to systems comprising an optical element having a refraction modulating composition and a wavefront sensor.  An embodiment is described in which the optical element is an intraocular lens. Optical aberrations of the lens measured by the wavefront sensor are corrected by photo-polymerization of the refraction modulating composition which alters the refractive properties of the lens. Correction of lens refractive errors can be carried out after the lens has been implanted in the eye.
Patent CA-2405027-A1 (CA)
Inventor: NAIR CHENICHERI HARIHARAN
IPC: B03C5/00
Filed: 2001-04-17
Abstract: An electrophoretic separation apparatus for separating micromolecules, the apparatus comprising: (a) a cathode; (b) an anode disposed relative to the cathode so as to be adapted to generate an electric field in an electric field area therebetween upon application of a voltage potential between the cathode and the anode; (c) a separation membrane disposed in the electric field area;  (d) a first restriction membrane disposed between the cathode and the separation membrane so as to define a first interstitial volume therebetween;  (e) a second restriction membrane disposed between the anode and the separation membrane so as to define a second interstitial volume therebetween;  and (f) means adapted to provide a sample constituent in a selected one of the first and second interstitial volumes; wherein upon application of the voltage potential, a selected separation product is removed from the sample constituent, through the separation membrane, and provided to the other of the first and second interstitial volumes, wherein a micromolecule is capable of being retained in at least one of the interstitial volumes.
Patent CA-2408167-A1 (CA)
Inventor: YUAN JEAN
IPC: C12N15/62
Filed: 1998-12-01
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Patent CA-2408476-A1 (CA)
Title: Grooved brachytherapy sources
Inventor: TORNES AUDUN
IPC: G21G4/08
Filed: 2001-04-12
Abstract: Radioactive sources, preferably radioactive seeds, for use in brachytherapy comprising a radioisotope within a sealed biocompatible container, wherein at least one part of the outer surface of the container is grooved, preferably with a curved groove. The grooved outer surface is preferably substantially free from angularities. Such grooves enhance the echogenicity of the source using medical ultrasound at a greater range of angles to the ultrasound probe, thus enhancing the ultrasound visibility of the source. Preferred radioisotopes are palladium-103 and iodine-125.
Patent CA-2410661-A1 (CA)
Inventor: EVERS MARC FRANCOIS THEOPHILE
IPC: C11D1/75
Filed: 2001-06-27
Abstract: La présente invention concerne un procédé de nettoyage d'une surface dure à l'aide d'une composition liquide neutre à alcaline. Cette composition comprend un polymère et un système tensio-actif. Ce dernier système comporte un agent tensio-actif anionique sulfaté ou sulfoné, un agent tensio actif de neutralisation coopérant et un agent tensio-actif non ionique alcoxylé
Patent CA-2411753-A1 (CA)
Inventor: COMBE ROBERT
IPC: B06B3/00
Filed: 2001-06-05
Abstract: A rotary sonotrode enabling welding to be carried out continuously over a large width. A sonotrode (S) more particularly of revolution, made of a first material for propagation of ultrasonic waves, more particularly metal, comprising a axial bar ( 2 ) and an active part ( 4 ) connected to the axial part ( 2 ), the bar extending uninterruptedly over the entire axial extent of the sonotrode, and a chamber ( 8 ), made of a second material which does not allow the transmission of ultrasonic waves from the first material to the second, the second material being more particularly air or avoid, is interposed between the bar ( 2 ) and the active part ( 4 ).
Patent CA-2412143-A1 (CA)
Inventor: LI YI
IPC: C12N1/21
Filed: 2001-02-08
Abstract: La présente invention concerne des cellules transgéniques qui ont été modifiées au moyen d'acides nucléiques codant pour des polypeptides de glycosyltransférase (GTases), et des vecteurs destinés à être utilisés pour la modification desdites cellules.
Patent CA-2413871-A1 (CA)
Inventor: MENARD RENE
IPC: B32B27/18
Filed: 2002-12-10
Abstract: The invention concerns a barrier composition, surface covering products incorporating a barrier layer, methods for making such surface covering products and methods for inhibiting or preventing the migration of sub-surface stains to the decorative portions of the surface covering products. The barrier composition comprises thermoplastic latex. The barrier composition is applied to the lower surface of the substrate of a decorative surface covering, or the lower surface of a basecoat on the substrate, and is then heat cured to obtain the barrier layer.
Patent CA-2417761-A1 (CA)
Inventor: GRDINA JEROME M
IPC: G06Q30/02
Filed: 2000-08-09
Abstract: Publié sans précis
Patent CA-2419030-A1 (CA)
Inventor: SCOTT MALCOLM
IPC: A61K31/506
Filed: 2001-08-06
Abstract: L'invention concerne des nouveaux dérivés 4-pyrimidinamines, neuroprotecteurs, ainsi que des compositions pharmaceutiques neuroprotectrices comprenant ces 4-pyrimidinamines. L'invention concerne également des procédés d'utilisation de ces compositions dans la prévention de la mort cellulaire ischémique, notamment la mort cellulaire neuronale, et dans la réduction de la possibilité de mort cellulaire neuronale chez un sujet, par suite d'un événement traumatique. Enfin, l'invention concerne un dispositif d'administration, à un sujet, des compositions pharmaceutiques décrites.
Patent CA-2421301-A1 (CA)
Inventor: LIN MON-SHENG
IPC: B65D39/12
Filed: 2003-03-07
Abstract: A container stopper adapted to seal the mouth of a container is disclosed to include a hollow elastic stopper body insertable into the mouth of a container, and a plug rod inserted into the axially extended center through hole of the stopper body and vertically moved between a first position, where the stopper body is radially expanded by the plug rod against the periphery of the mouth of the container to seal the mouth of the container, and a second position, where the plug rod released the pressure from the stopper body, for enabling the stopper body to be removed from the mouth of the container.
Patent CA-2422603-A1 (CA)
Title: Vectors for molecule delivery to cd11b expressing cells
Inventor: BAUCHE CECILE
IPC: C12N5/0784
Filed: 2001-09-14
Abstract: The invention relates to a novel use of a Bordetella adenylcyclase toxin in the manufacturing of vectors for targeting in vivo a molecule of interest, specifically to CD11b expressing cells. The invention also relates to an immunogenic composition that primes immune responses, to pharmaceutical compositions and to a new vector for molecule delivery to CD11b expressing cells.
Patent CA-2424489-A1 (CA)
Title: Compactor device
Inventor: GUNTVEIT LARS
IPC: B30B9/32
Filed: 2001-09-20
Abstract: A compactor device for the automatic compacting of empty containers (5), e.g.  disposable bottles/cans of metal, plastic, glass or other suitable material, wherein the container (5) is essentially being pressed flat and possibly punctured, possibly crushed, and wherein the compacting area is formed by a cuneiform area between a conveyor belt (20) and a first jaw set (36a) and a second jaw set (36b), and wherein a plurality of jaws (32), which are provided with teeth on their active side, are arranged in such a way that each alternate jaw (32), as seen transversally to the longitudinal direction of the conveyor belt (20), is connected to the jaw sets (36a) and (36b) respectively, the jaw sets (36a) and (36b) being rotatably connected to two common eccentric shafts (38, 38'), and the eccentric shafts (38, 38') being formed in such a way that the eccentric motion of the jaw sets (36a, 36b) is out of phase, typically by 180 degrees.
Patent CA-2425219-A1 (CA)
Title: Dispositif et systeme d'indication de deceleration brutale pour vehicule
Inventor: FOWLER J THOMAS
IPC: B60Q1/44
Filed: 2001-03-16
Abstract: Cette invention concerne un dispositif et un système d'indication de décélération brutale et de mise en garde en conséquence du conducteur et/ou d'autres personnes. Le dispositif comprend un ou plusieurs détecteurs qui réagissent à l'accélération dans le sens de déplacement principal du véhicule. L'unité de commande, qui communique avec un ou plusieurs détecteurs, corrige les effets gravitationnels et déclenche au moins un témoin de mise en garde lorsque l'accélération détectée dépasse une valeur de seuil et indique par là même un état de décélération brutale.
Patent CA-2425560-A1 (CA)
Title: Anticholinergics, processes for preparing them and their use as pharmaceutical compositions
Inventor: PIEPER MICHAEL PAUL
IPC: C07D451/14
Filed: 2001-09-28
Abstract: The invention relates to novel anticholinergics of general formula (1) wherein A, X- and the radical R1, R2, R3, R4, R5, R6, R7 and R8 can have the meaning as cited in the claims and the description. The invention also relates to the production thereof in addition to the use thereof as medicaments.
Patent CA-2426243-A1 (CA)
Inventor: WILSON MINOR
IPC: H01Q1/32
Filed: 2003-04-17
Abstract: An arrangement and method for incorporating one or more communications antennas in the light bar of an emergency vehicle. The antennas can be totally within the light bar or partially within and extending out from the light bar. The antennas can be incorporated in light bars having either metal or plastic covers or tops. Various ground planes such as the light bar metal top, the track within the light bar or a metal strap secured to the top of a plastic light bar cover can be utilized. Both capacitive and direct feed methods for the antennas cam be employed and at any frequency.      Known filtering arrangements are provided to accommodate the various communication bands involved.
Patent CA-2427104-A1 (CA)
Inventor: HAMID-SAMIMI MOHAMMAD HOSSEIN
IPC: A23L15/00
Filed: 1999-12-03
Abstract: A process for producing pasteurized liquid egg product utilizing a vat or tank for holding raw egg product. The raw egg product is preheated as rapidly as possible to a temperature of about 60 ~C and then, without holding the temperature at a constant level, the preheated raw egg is transferred to a suitable package. The package containing the preheated raw egg product is then sealed and heated and maintained at a suitable temperature in order to pasteurize the liquid raw egg products in the packages. The heated containers and pasteurized liquid egg product ware then cooled rapidly to a refrigeration temperature to further inhibit germination of any remaining bacterial spores.  The containers are then stored in refrigeration conditions for distribution and use. In another embodiment, an egg product package is preheated to a temperature between about 71 ~C and 55 ~C and then hot filled with a egg product treated to about the same temperatures as the package. The hot filled package is then sealed and allowed to stand for at least 30 seconds and then it is rapidly cooled to at least about 5 ~C in a cooling time period of about 5 minutes.
Patent CA-2427287-A1 (CA)
Inventor: JOHNSON BRUCE D
IPC: F16G11/00
Filed: 2003-04-30
Abstract: The cable clamp is mountable to a supporting structure and includes a base and a cover mountable to the base. The base is longitudinally elongated and has a channel extending longitudinally therethrough with longitudinally spaced, elongated, somewhat bubble shaped recesses opening upwardly through the channel web. Transversely spaced lands provide the side walls of the channel. The cover is longitudinally elongated and has a top wall with flanges dependingly joined to the perimetric edge of the cover. A longitudinally extending ridge is dependingly joined to the top wall whereby, in conjunction with the flanges, there are provided cavities of a size to have the base lands extended therein. The ridge has spaced protrusions alignable with the base recesses to force the cable thereinto when extended through the channel when the clamp screws are tightened to retain the cover in clamping relationship to the base.
Patent CA-2428087-A1 (CA)
Inventor: BROWN DANIEL P
IPC: B05B7/04
Filed: 2001-10-26
Abstract: An improved metering apparatus is provided for use with a foam dispenser (20) that disperses beads of foam after mixing streams of two foam components together. The dispenser (20) has a pair of inlet passages (23) formed in a body portion (21) of dispenser (20) and a spool valve (40) rotatably mounted in the body portion (21). The spool valve (40) has a pair of flow passages (48) formed in it that can be rotated into mating alignment with the inlet passages (23) formed in the dispenser body portion (21). The spool valve flow passages (48) have circular cross-sections while the inlet passages (23) have non-circular cross-sections, and preferably triangular cross-sections.
Patent CA-2430621-A1 (CA)
Inventor: PEREZ RODRIGUEZ ROLANDO
IPC: A61K47/48
Filed: 2001-12-06
Abstract: The invention relates to a vaccine composition capable of producing a specific immune response against autologous TGF alpha, which contains TGF alpha or any derivative thereof and active ingredients and an appropriate adjuvant. The vaccine preparation can also include a combination of TGF alpha and other growth factors such as epidermic growth factor (EGF) in such a way that it inhibits the proliferation of tumors whose progression depends on said factors. The growth and proliferation of epidermoid carcinomas can be controlled with the use of said composition.
Patent CA-2433245-A1 (CA)
Inventor: VOUVALIDIS GUS
IPC: A63B71/14
Filed: 2003-06-25
Abstract: The present invention provides a split-fingered glove comprising: a hand-receiving portion for receiving a hand; and, one or more padded finger-receiving portions extending from the hand-receiving portion, one or more of the finger-receiving portions having one or more flexible articulations at a back thereof and having a shield or shields over the one or more articulations to protect one or more finger joints, the shield or shields being engaged with and slidably constrained by the finger-receiving portion, the shield or shields sliding in response to curling and uncurling the hand. The glove provides better protection and support for fingers than prior art split-fingered gloves, and is particularly useful in sporting activities such as hockey and lacrosse.
Patent CA-2434387-A1 (CA)
Title: Marqueur susceptible d'etre selectionne pour des cellules et des tissus genetiquement modifies
Inventor: MOMPARLER RICHARD L
IPC: G01N33/50
Filed: 2002-01-16
Abstract: L'invention concerne un gène marqueur susceptible d'être sélectionné, un procédé de production de cellules génétiquement modifiées permettant l'expression d'un vecteur bicistronique et des applications en thérapie génique ex vivo. L'invention concerne également la sélection de cellules génétiquement modifiées provenant de population mixte, avant leur implantation in vivo. L'invention concerne en outre le gène humain de la cytidine déaminase (CD) tenant lieu de marqueur dominant susceptible d'être sélectionné ex vivo dans des cellules primaires à gène modifié avec des analogues de la cytosine nucléoside. Un rétrovecteur bicistronique comprenant la séquence codant la CD humaine et le gène rapporteur de la protéine fluorescente verte (GFP) améliorée est utilisé dans la transduction de cellules. L'invention concerne finalement l'introduction du gène CD dans les applications en thérapie cellulaire et génique pour la sélection dominante ex vivo de cellules génétiquement modifiées.
Patent CA-2436351-A1 (CA)
Title: 3,4-di-substituted cyclobutene-1, 2-diones as cxc chemokine receptor antagonists
Inventor: LI GE
IPC: C07D277/56
Filed: 2002-02-01
Abstract: There are disclosed compounds of formula (I) wherein the variables A and B a re an aryl or heteroaryl group as defined in the claims, or a prodrug thereof, or a pharmaceutically acceptable salt, solvate or isomer of said compound or of said prodrug, which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.</SDOAB >