Patent RU-2508135-C2 (RU)
Inventor: GONZALEZ BERNARD A
IPC: A61M5/145
Filed: 2010-07-27
Granted: 2014-02-27
Abstract: FIELD: medicine. 
     SUBSTANCE: invention refers to medical equipment, namely to devices for subcutaneous injections. The device comprises a body, a liquid container having an opened end and an applicator in the form of a drug cartridge having a first primary surface comprising a microneedle matrix, a liquid canal connecting the opened end of the container with the microneedle matrix, a first pressure accumulator and a second pressure accumulator. The applicator and the container are independently integrated in the body. The first pressure accumulator can apply a force to the applicator to project it in the direction substantially perpendicular to the first primary surface. The second pressure accumulator can automatically open the opened end of the container to form a liquid connection between the opened end of the container and the liquid canal, as well as to push the liquid through the opened end of the container, liquid canal and microneedle matrix. According to the second version of the device, the body comprises a common actuator functionally connected with the first and second pressure accumulators and actuating the first and second pressure accumulators. The first pressure accumulator comprises a spring with two bases covering the container from two sides, and a segment contacting the applicator. The spring is substantially U-shaped, and if unstressed, the spring is in a close proximity to the container, substantially in parallel with its longitudinal axis. The method involves the stages to provide the body comprising the drug cartridge with the opened end, the applicator having the first primary surface comprising the microneedle matrix, and the pressure accumulator used to apply a force to the applicator in the direction substantially perpendicular to the first primary surface. The pressure accumulator comprises the spring with two bases covering the container from two sides, and the segment contacting the applicator. The spring is substantially U-shaped, and if unstressed, the spring is in a close proximity to the container, substantially in parallel with its longitudinal axis. The microneedle matrix is automatically moved in the direction perpendicular to the first primary surface. The opened end of the cartridge is automatically opened. The fluid connection is formed between the opened end of the cartridge and the microneedle matrix. The fluid is automatically pushed out from the drug cartridge through the opened end of the cartridge into the microneedle matrix. According to the third version, the first pressure accumulator comprises the spring with two bases covering the container from two sides, and the segment contacting the applicator. The spring is substantially U-shaped, and if unstressed, the spring is in a close proximity to the container, substantially in parallel with its longitudinal axis. The presented devices can be actuated in one movement, thereby providing automatic and reliable patient's skin needling by the microneedle matrix and then automatic release and cutaneous introduction of the liquid placed into the ready-to-use drug cartridge in a controlled mode that provides the adequate digestion of this liquid. 
     EFFECT: effective delivery of a wide variety of the liquids meeting the user's demands and dosage individual for each specific patients can be achieved by the relatively injury-free method with a minimised probability of hollow microneedle displacement in skin penetration and the amount of the liquid remained in the device after introduction into the patient. 
     35 cl, 33 dwg