Patent SG-11201908618S-A (SG)
Title: Chimeric polypeptides and methods of altering their localisation in the cell membrane
Inventor: SANTORO STEPHEN
IPC: C07K14/725
Filed: 2018-03-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I PCT °Hum No oimIE (10) International Publication Number WO 2018/183551 Al (51) International Patent Classification: C07K 14/725 (2006.01) A61K 38/17 (2006.01) CO7K 14/72 (2006.01) (21) International Application Number: PCT/US2018/024916 (22) International Filing Date: 28 March 2018 (28.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/477,733 28 March 2017 (28.03.2017) US 62/587,262 16 November 2017 (16.11.2017) US (71) Applicant: CELL DESIGN LABS, INC. [US/US]; 5858 Horton St., Suite 240, Emeryville, California 94608 (US). (72) Inventors: SANTORO, Stephen; 574 Southhill Blvd., Daly City, California 94014 (US). COYLE, Scott; 550 S Van Ness Ave #401, San Francisco, California 94110 (US). RUPP, Levi; 234A Corbett Ave., San Francisco, California 94114 (US). EMTAGE, Peter; 3603 Walnut St., Lafayette, California 94549 (US). (74) Agent: REITER, Tiffany et al.; Fish & Richardson P.C., P.O. Box 1022, Minneapolis, Minnesota 55440-1022 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (54) Title: CHIMERIC POLYPEPTIDES AND METHODS OF ALTERING THEIR LOCALISATION IN THE CELL MEMBRANE 1-1 1-1 FIG. 1 (57) : Methods and compositions are provided for reversibly localizing proteins to the exterior part of the cell surface. Essen- tially, the protein must comprise, in addition to a transmembrane domain, also a hormone receptor like the estrogen receptor alpha or the progesterone receptor. Compositions provided herein can include nucleic acids that encode polypeptides of interest and the ligand bind- = ing domain (LBD) of a nuclear hormone receptor. Medical applications are provided, including controlling the toxicity of CART cells. C [Continued on next page] WO 2018/183551 Al MIDEDIM011111 1111E111 IEM0ME1111OM1111 III1111111110111111111111 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))