Patent MX-2008014990-A (MX)
Title: Biphenyl derivatives and their use in treating hepatitis c.
Inventor: MATHEWS NEIL
IPC: C07D333/20
Filed: 2007-03-21
Abstract: Compounds of formula (I) are found to be active against HCV. wherein: R<sub>1</sub> is a moiety -A<sub>1</sub>-L<sub>1</sub>-A<sub>1</sub>', -A<sub>1</sub>-L<sub>1</sub>-A<sub>1</sub>'-A<sub>1</sub>" or -A<sub>1</sub>-L<sub>1</sub>-A<sub>1</sub>'-Y<sub>1</sub>-A<sub >1</sub>"; A and B are the same or different and each represent a direct bond or a -CO- NR'-, -NR'-CO-, -NR'-CO-NR"-, -NR'-S(O)<sub>2</sub>-, -S(O)<sub>2</sub>-NR'- or -NR'- moiety, wherein R' and R" are the same or different and each represent hydrogen or C<sub>1</sub>-C<sub>4</sub> alkyl; R<sub>2</sub> and R<sub>3</sub> are the same or different and each represent C<sub>1</sub>-C<sub>4</sub> alkyl, C<sub>1</sub>-C<sub>4</sub> alkoxy, C<sub>1</sub>-C<sub>4</sub> alkylthio, C<sub>1</sub>-C<sub>4</sub> haloalkyl, C<sub>1</sub>-C<sub>4</sub> haloalkoxy, halogen, hydroxy, thio, -NR'R", -SO<sub>2</sub>-R'", -NR'-COR'" or -CO<sub>2</sub>R'", wherein R' and R" are the same or different and represent hydrogen or C<sub>1</sub>-C<sub>4</sub> alkyl and R'" represents C<sub>1</sub>-C<sub>4</sub> alkyl; n and m are the same or different and each represent 0, 1 or 2; R<sub>4</sub> is a C<sub>1</sub>-C<sub>6</sub> alkyl or C<sub>1</sub>-C<sub>6</sub> haloalkyl group or a moiety -A<sub>4</sub>, -A<sub>4</sub>-A<sub>4</sub>', -L<sub>4</sub>-A<sub>4</sub>, -A<sub>4</sub>-L<sub>4</sub>-A<sub>4</sub>', -A<sub>4</sub>-Het<sub>4</sub>-L<sub>4</sub>-Het<sub>4</sub>'-L <sub>4</sub>' or -L<sub>4</sub>-Het<sub>4</sub>-L<sub>4</sub>', - each A<sub>1</sub>, A<sub>4</sub>, A<sub>1</sub>', A<sub>1</sub>" and A<sub>4</sub>' are the same or different and represent a phenyl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl or C<sub>3</sub>-C<sub>6</sub>carbocyclyl moiety; each L<sub>1</sub> and L<sub>4</sub> is the same or different and represents a C<sub>1</sub>-C<sub>4</sub>alkylene or a C<sub>1</sub>-C<sub>4</sub> hydroxyalkylene group; - Y<sub>1</sub> represents -CO-NR'-, -CO-( C<sub>1</sub>-C<sub>4</sub> alkylene)-, -CO-( C<sub>1</sub>-C<sub>4</sub> alkylene)-NR'-, -NR'-CO-, -CO-, -O-CO- or -CO-O-, wherein R' is hydrogen or C<sub>1</sub>-C<sub>4</sub> alkyl; L<sub>4</sub>' represents hydrogen or a C<sub>1</sub>-C<sub>4</sub> alkyl group; Het<sub>4</sub> and Het<sub>4</sub>' are the same or different and represent -O-, -S- or -NR'-, wherein R' is hydrogen or a C<sub>1</sub>-C<sub>4</sub> alkyl group; the phenyl, heteroaryl, heterocyclyl and carbocyclyl moieties in R<sub>1</sub> and R<sub>4</sub> being unsubstituted or substituted by (a) a single unsubstituted substituent selected from -CO<sub>2</sub>R', -SO<sub>2</sub>NR"R', -S(O)<sub>2</sub>-R', -CONR"R", -COR'", -CO-CO-OR''', -CO-( C<sub>1</sub>-C<sub>4</sub> alkylene)-OR", -CO-( C<sub>1</sub>-C<sub>4</sub> alkylene)-NR"R", -CO-( C<sub>1</sub>-C<sub>4</sub> alkylene)-NR"-CO-R''', -CO- (C<sub>1</sub>-C<sub>4</sub> alkylene)-CO-NR"R", -CO-( C<sub>1</sub>-C<sub>4</sub> alkylene)-SO<sub>2</sub>-R'", -CO-( C<sub>1</sub>-C<sub>4</sub> alkylene)-O- (C<sub>1</sub>-C<sub>4</sub> alkylene)-OR", -CO-( C<sub>1</sub>-C<sub>4</sub> alkylene)-O-( C<sub>1</sub>-C<sub>4</sub> alkylene)-NR"R", -CO-( C<sub>1</sub>-C<sub>4</sub> alkylene)-NR"-( C<sub>1</sub>-C<sub>4</sub> alkylene)-OR", -CO-( C<sub>1</sub>-C<sub>4</sub> alkylene)-NR"-( C<sub>1</sub>-C<sub>4</sub> alkylene)- NR"R", -SO<sub>2</sub>-( C<sub>1</sub>-C<sub>4</sub> alkylene)-OR", -NR"-SO<sub>2</sub>-R'", -( C<sub>1</sub>-C<sub>4</sub> alkylene)-CO-( C<sub>1</sub>-C<sub>4</sub> alkylene)-CO<s.