Patent SG-11201805940Q-A (SG)
Title: Benzopyrazole compounds and analogues thereof
Inventor: KOTIAN PRAVIN
IPC: C07K16/28
Filed: 2017-02-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101110011011001111111101111101111011111 International Bureau .. .... ..Yejd (10) International Publication Number ..... .....1 (43) International Publication Date WO 2017/136395 Al 10 August 2017(10.08.2017) WIPO I PCT (51) International Patent Classification: (74) Agents: GORDON, Dana, M. et al.; Foley Hoag LLP, 155 C07K 16/28 (2006.01) A61P 9/00 (2006.01) Seaport Blvd., Boston, MA 02210-2600 (US). A61K 39/00 (2006.01) A61P 37/06 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/US2017/015953 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (22) International Filing Date: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 1 February 2017 (01.02.2017) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (25) Filing Language: English KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (26) Publication Language: English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (30) Priority Data: RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 62/289,653 1 February 2016 (01.02.2016) US TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: BIOCRYST PHARMACEUTICALS, INC. [US/US]; 4505 Emperor Boulevard, Durham, NC 27703 (84) Designated States (unless otherwise indicated, for every (US). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, — (72) Inventors: KOTIAN, Pravin, L.; 1313 Atkins Trimm TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Boulevard, Birmingham, AL 35226 (US). BABU, Yar- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, lagadda, S.; 4836 Southlake Parkway, Birmingham, AL DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 35244 (US). ZHANG, Weihe; 2645 Manchester Court, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Vestavia, AL 35226 (US). VOGETI, Lakshminarayana; SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, 2938 Columbia Court, Apt.A, Vestavia, AL 35216 (US). GW, KM, ML, MR, NE, SN, TD, TG). = WU, Minwan; 2709 Paden Trail, Vestavia Hills, AL 35226 (US). CHINTAREDDY, Venkat, R.; 6157 Crowne Published: Falls Parkway, Hoover, AL 35244 (US). RAMAN, Krish- — with international search report (Art. 21(3)) nan; 3739 Spearman Drive, Birmingham, AL 35244 (US). = = = = = = = = = = Title: BENZOPYRAZOLE COMPOUNDS AND ANALOGUES THEREOF = (54) 0 R 2 R 3 Ra B I 1-1 11 in N R 1 .... N m .., Y I C:7 R 4 en (I) M 1-1 IN Il (57) : Disclosed are compounds of formula (I), and pharmaceutically acceptable salts thereof. The compounds are inhibitors 0 of the complement system. Also provided are pharmaceutical compositions comprising a compound of formula (I), and methods in- \" volvm • g use of the compounds and compositions in the treatment and prevention of diseases and conditions characterized by aberrant 0 complement system activity.