baber/WOPTO huggingface dataset:
Patent CA-3137247-A1 (CA)
Title: Treatment of cutaneous lupus erythematosus
Inventor: NIELSEN JACOB
IPC: A61K9/00
Filed: 2020-05-14
Abstract: The present invention relates to the treatment of cutaneous lupus erythematosus. The problem to be solved by the invention is to provide a new pharmaceutical use of 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1- yl]-3-oxopropanenitrile. A therapeutic or preventive agent cutaneous lupus erythematosus, containing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- 1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile as an active ingredient, and a pharmaceutical formulation thereof.
Patent CA-3137813-A1 (CA)
Title: Display system and display method
Inventor: TAKAHAMA KAZUHISA
IPC: G06T17/05
Filed: 2020-05-26
Abstract: This display system of a working machine is provided with: an acquisition unit which acquires three-dimensional data of a plurality of measurement points; a conversion unit which converts the three-dimensional data into a vehicle body coordinate system; an image generation unit which generates, on the basis of the three-dimensional data converted into the vehicle body coordinate system, a reference image representing a three-dimensional shape of the topography; and a display processing unit which superposes the reference image onto a captured image and displays the superposed image, wherein the image generation unit determines the display type of the reference image at a position corresponding to each of the measurement point on the reference image according to a distance of the measurement point in a normal direction with respect to the grounding surface of the working machine.
Patent CA-3138737-A1 (CA)
Inventor: FISCHER BURTON D
IPC: B60K13/02
Filed: 2019-05-22
Abstract: Un véhicule tout-terrain comprend : un châssis comprenant une partie de châssis principal, ainsi quun sous-ensemble de châssis avant qui comprend des éléments essentiellement verticaux et des éléments sétendant vers larrière; des éléments de contact avec le sol soutenant le châssis, y compris des éléments de contact avec le sol avant et arrière; une zone dopérateur ou dopératrice comprenant un mécanisme dentrée de direction, un siège et des places pour les pieds; un moteur soutenu par le châssis et positionné à lintérieur dune enveloppe de la zone dopérateur ou dopératrice; un radiateur raccordé à une surface supérieure des éléments sétendant vers larrière et généralement parallèle aux éléments sétendant vers larrière du sous-ensemble de châssis avant; un treuil raccordé aux éléments essentiellement verticaux du sous-ensemble de châssis avant, et le treuil étant positionné en avant du radiateur; et une boîte à vent positionnée de manière longitudinale et intermédiaire par rapport au moteur, ainsi que le radiateur positionné latéralement intermédiaire par rapport aux éléments de contact avec le sol.
Patent CA-3140185-A1 (CA)
Inventor: LIPKENS BART
IPC: A61M1/36
Filed: 2020-05-15
Abstract: La présente invention concerne une onde acoustique avec un champ acoustique ayant un grand nombre de gradients multidirectionnels qui peut fournir un effet de bord utilisé pour former une région d'interface par rapport à l'onde acoustique. La région d'interface peut bloquer un matériau ayant certaines caractéristiques liées à la nature de la région d'interface. D'autres matériaux qui sont moins influencés par les propriétés acoustiques de la région d'interface peuvent passer à travers l'onde acoustique. Cette technique permet la séparation de matériaux à l'aide de l'effet de bord et de la région d'interface.
Patent CA-3140267-A1 (CA)
Title: Compositions and methods for increasing reproduction performance in non-human mammals using recombinant luteinizing hormone
Inventor: VALENZA ALESSIO
IPC: A61K31/5575
Filed: 2020-05-18
Abstract: The present invention relates to methods and compositions for increasing reproduction performance in non-human mammals using recombinant luteinizing hormone (rLH) in a low dose. The invention also relates to methods for increasing follicle growth rates at later stages of synchronization programs, improving ovulation results, corpus luteum (CL) development after ovulation, or pregnancies in non-human mammal using rLH in a low dose. The invention is preferably used in ungulates such as bovine, in association to synchronization programs for timed ovulation.
Patent CA-3140358-A1 (CA)
Title: Dephosphorylated lysosomal storage disease proteins and methods of use thereof
Inventor: VITALIS TIMOTHY Z
IPC: A61P3/00
Filed: 2013-07-31
Abstract: Provided are substantially dephosphorylated forms of lysosomal storage disease (LSD) proteins, including dephosphorylated forms of iduronate-2-sulfatase (IDS, or I2D) and iduronidase (IDU), having increased ability to traverse or penetrate the blood brain barrier (BBB) relative to phosphorylated forms of the protein, and p97 conjugates thereof. Also provided are compositions comprising such dephosphorylated LSD proteins and p97 conjugates, and methods of use thereof, for instance, to treat any one or more lysosomal storage diseases, such as H  unter Syndrome (or MPS  Type II).
Patent CA-3140576-A1 (CA)
Title: Circulation valve
Inventor: BUCKLAND JONATHAN PETER
IPC: E21B34/10
Filed: 2020-06-10
Abstract: A circulation valve for a well, with a housing allowing fluid flow with an outlet from the housing and a control sleeve controlling flow through the outlet. A support member supports the control sleeve, closing the outlet when the valve is in compression. The support member is slidable with respect to the control sleeve and disengages from the control sleeve when the valve is in tension, permitting movement of the control sleeve to open the outlet in response to a minimum flow rate through the valve while the valve is in tension.
Patent CA-3142042-A1 (CA)
Title: Methode et systeme de surveillance de l'hemodynamique
Inventor: LEVY BARUCH
IPC: A61B5/318
Filed: 2012-07-25
Abstract: Un système de surveillance de lhémodynamique d'un sujet est décrit. Le système comprend : un système de génération de signal configuré pour produire au moins un signal électrique de sortie et lenvoyer à un organe du sujet. Le système comprend également un système de démodulation configuré pour recevoir un signal électrique d'entrée, détecté dans l'organe en réponse au signal électrique de sortie, et démoduler le signal d'entrée à l'aide du signal de sortie afin de produire une composante en phase et une composante en quadrature du signal d'entrée. Le système comprend également un système de traitement configuré pour surveiller l'hémodynamique en fonction des composantes en phase et en quadrature.
Patent CA-3142185-A1 (CA)
Title: Peptides and uses thereof
Inventor: KENLEY DAVID
IPC: A61K38/27
Filed: 2020-05-29
Abstract: The present disclosure relates to the use of C-terminal fragments of human and non-human growth hormone, synthetic cyclic peptides and C-terminal fragments of human prolactin precursor for the treatment of migraine in a subject in need thereof.
Patent CA-3144006-A1 (CA)
Title: Transdermal penetrant formulations
Inventor: FITZSIMMONS NATHAN
IPC: A61Q19/00
Filed: 2020-06-18
Abstract: Disclosed herein is a transdermal delivery formulation for transdermal delivery of an active agent through the skin, nail or hair follicle of a subject, wherein the formulation comprises a) a transdermal delivery formulation in an amount less than about 60 %w/w, comprising i. one or more phosphatides, ii. glucose, and iii. one or more fatty acids; and b) water in an amount less than about 50 %w/w.
Patent CA-3144620-A1 (CA)
Title: Modified yeast and method for increasing lysine content in fermentation co-products
Inventor: DEMARTINI JACLYN DIANA
IPC: C12P13/08
Filed: 2020-06-22
Abstract: Described are strains and methods relating to genetically-engineered yeast cells that overproduce lysine in a tunable manner by altering feedback inhibition of the lysine synthetic pathway by way of the LYS20 and LYS21 homocitrate synthase polypeptides. The yeast can be used in a conventional bioethanol production facility to produce alcohol along with increased amounts of lysine, resulting in increased quality and commercial value of fermentation products and co-products, such as animal feed ingredients.
Patent CA-3145477-A1 (CA)
Inventor: ROTHMAN JEFFREY HAROLD
IPC: A61K38/16
Filed: 2020-07-22
Abstract: La présente invention concerne, entre autres, des agents à base d'ANP améliorés, des compositions les comprenant, et des méthodes de traitement de maladies telles que des cancers à l'aide de tels agents et/ou de telles compositions. L'invention concerne également des méthodes de réduction de l'expression d'un gène dans une cellule.
Patent CA-3147734-A1 (CA)
Inventor: LEVINE JONAH
IPC: B29C37/00
Filed: 2020-07-16
Abstract: L'invention concerne un procédé de fabrication d'une litière pour animaux à partir d'une matière première de biomasse d'origine forestière, les modifications de performances étant sensiblement situées entièrement sur la surface extérieure des particules de biomasse d'origine forestière. Le procédé peut comprendre les étapes de densification de la matière première de biomasse, d'émiettement de la matière de biomasse densifiée ; de criblage de la matière de biomasse densifiée pour la taille ; éventuellement d'ajout d'une zéolite contenant un parfum ; de revêtement par pulvérisation des particules de biomasse densifiées, dimensionnées avec un agent d'adhérence de surface ; et de dosage de poudre des particules de biomasse densifiées, dimensionnées et des zéolites avec une modification des performances comprenant des parties égales de bentonite et de gomme de guar.
Patent CA-3147992-A1 (CA)
Title: Systems and methods for adaptive output
Inventor: BEGAN ALI C
IPC: H04N21/442
Filed: 2022-02-07
Abstract: Based on characteristics associated with content, at least one portion of the content during which an output speed change satisfies a threshold may be determined. The threshold may be a "detectability" threshold, indicative of whether a viewer of the content may detect an output speed change during that portion of the content. The at least one portion of the content during which an output speed change satisfies the threshold may be associated with a rate of speed change. During output of the content, if it is determined that an output speed change is necessary, the output speed may be changed during the at least one portion in accordance with the rate of speed change.
Patent CA-3149302-A1 (CA)
Title: Substituted cyclopropyl-2,2'-bipyrimidinyl compounds, analogues thereof, and methods using same
Inventor: CHEN SHUAI
IPC: A61P31/12
Filed: 2020-07-31
Abstract: The present disclosure includes novel substituted cyclopropyl-2,2'-bipyrimidinyl compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infection and/or hepatitis D virus (HDV) infection in a patient.
Patent CA-3149883-A1 (CA)
Inventor: CAI SUI XIONG
IPC: A61P35/02
Filed: 2020-09-11
Abstract: The disclosure provides substituted imidazo [1, 5-a] quinoxaline and related compounds as kinase inhibitors, and their uses. Specifically, the disclosure provides compounds of Formula I, or pharmaceutically acceptable salts thereof or prodrugs thereof, wherein, A <sub>1</sub>-A <sub>3</sub>, Cy and R <sub>1</sub>-R <sub>2</sub> are defined herein. The compounds of Formula I are kinase inhibitors. Therefore, the compounds of the disclosure can be used to treat clinical conditions caused by DDR function defects, such as cancers. (I)
Patent CA-3151387-A1 (CA)
Title: Lipid compositions for the delivery of therapeutic agents
Inventor: MANOHARAN MUTHIAH
IPC: C07D403/12
Filed: 2010-05-05
Abstract: Disclosed herein are lipid compositions comprising a cationic lipid of formula (IV), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (IV) is   Also disclosed are methods of producing the cationic lipid of formula (IV).
Patent CA-3151521-A1 (CA)
Inventor: GYORY J RICHARD
IPC: A61J1/20
Filed: 2020-09-25
Abstract: A medicament filling system (30) provides medicament to a delivery device (20). The medicament filling system (30) comprises a main housing (40) having an air pump (42), a vial adapter (44) that is configured to engage a vial (10) containing medicament, the vial adapter (44) being in communication with the air pump (42), a syringe housing (46) that carries a syringe (70), the syringe housing (46) being in selective communication with the vial adapter (44) and the delivery device (20), and a valve (60) that locks and unlocks movement of a plunger (72) in the syringe (70).
Patent CA-3151942-A1 (CA)
Inventor: HOYON CHRISTOPHE
IPC: B61D3/10
Filed: 2020-09-21
Abstract: Ce dispositif d'articulation de véhicule articulé comprend une première bride (14), une deuxième bride (16), et un joint d'articulation (18) comprenant un premier organe d'articulation (20) comprenant un seul premier tronçon (52) et un deuxième organe d'articulation (22) comprenant un seul deuxième tronçon (60). Le premier tronçon (52) et le deuxième tronçon (60) sont mobiles en rotation l'un par rapport à l'autre, la première bride (14) est reliée au premier organe d'articulation (20) et la deuxième bride (16) est reliée au deuxième organe d'articulation (22). Le deuxième organe d'articulation (22) comprend un seul organe de liaison (66) par l'intermédiaire duquel le deuxième tronçon (60) est relié à la deuxième bride (16), l'organe de liaison (66) étant adapté pour ajuster la position du deuxième tronçon (60) par rapport à la deuxième bride (16) selon un axe longitudinal (X2-X2) et selon un axe transversal (Y2-Y2).
Patent CA-3153471-A1 (CA)
Inventor: BRAUN RAINER
IPC: A63G21/18
Filed: 2022-03-22
Abstract: The invention relates to a method for controlling a slide direction in a branch point (23) and a slide, in particular a water slide, in which a slide surface (19) of the branch point (23) is wetted with water, and the branch point (23) is formed: with a first slide connector (24) for a slide entrance, with a second slide connector (25) for a slide exit, with a third slide connector (27) for a further slide exit, wherein the first and second slide connector (24, 25) are provided adjacently to each other, and the third slide connector (27) is provided removed from or opposite the first and second slide connector (24, 25), and a mouth region (34) is formed between the first and second slide connector (24, 25) and the third slide connector (27). (See Figure 1)
Patent CA-3154006-A1 (CA)
Inventor: DA COSTA GARCIA MIGUEL ANGELO
IPC: A61K35/76
Filed: 2011-09-19
Abstract: The present invention is directed to the field of phage therapy for the treatment and control of bacterial infections. In particular, the present invention is directed to the novel bacteriophage F125/10, isolated polypeptides thereof, compositions comprising the novel bacteriophage and/or isolated polypeptides, as well as to methods for the treatment and prevention of bacterial infections using same, either alone or in combination with other antibacterial therapies, e.g., antibiotics and/or other phage therapies.
Patent CA-3154493-A1 (CA)
Inventor: LESCH PAUL
IPC: A61M25/09
Filed: 2020-09-14
Abstract: The present disclosure provides a guide wire system comprising (a) a guide wire having a distal end and a proximal end, wherein the guide wire comprises a superelastic material, (b) a first connector (108) coupled to the proximal end of the guide wire, (c) a second connector (110) coupled to the guide wire between the distal end and the proximal end, (d) an electromagnetic sensor (112) coupled to the distal end of the guide wire, and (e) a polymeric tube surrounding the guide wire and at least a portion of the electromagnetic sensor.
Patent CA-3158875-A1 (CA)
Title: Pyrimidone derivatives containing two fused bicyclic rings
Inventor: SHAIKH RIZWAN SHABBIR
IPC: A01N43/90
Filed: 2020-11-16
Abstract: The invention relates to a compound of formula (I), wherein the variables are defined in the specification. It also relates to a pesticidal mixture comprising the compound of formula (I); the use of compounds of formula (I) as an agrochemical pesticide; a method for combating or controlling invertebrate pests, a method for protecting growing plants from attack or infestation by invertebrate pests, seed comprising a compound of the formula (I); the use of a compound of the formula (I) for protecting growing plants from attack or infestation by invertebrate pests; and a method for treating or protecting an animal from infestation or infection by invertebrate pests.
Patent CA-3161216-A1 (CA)
Inventor: CRYSTAL JEREMY BURTON
IPC: B26D5/06
Filed: 2020-12-11
Abstract: A cutting machine includes a working surface, a carriage, a tool, and a drive mechanism. The carriage is disposed above the working surface. The tool is removably secured to the carriage and configured to move (i) toward the working surface along a first axis, (ii) relative to the working surface along a second axis transverse to the first axis, and (iii) relative to the working surface along a third axis transverse to the first axis and the second axis. The drive mechanism is offset from the first axis and configured to move the tool along the first axis.
Patent CA-3162261-A1 (CA)
Inventor: KLEY NIKOLAI
IPC: C07D491/107
Filed: 2020-12-16
Abstract: The invention provides cereblon binders for the degradation of proteins by the ubiquitin proteasome pathway for therapeutic applications.
Patent CA-3163353-A1 (CA)
Inventor: DRMANAC RADOJE
IPC: C12Q1/68
Filed: 2020-12-23
Abstract: L'invention concerne des procédés et des compositions utilisés pour le séquençage d'extrémités appariées. Le procédé comprend la Fourniture d'un réseau d'ADN comprenant une surface immobilisée avec des concatémères d'ADN. Pour chacun de la pluralité de concatémères d'ADN sur le réseau, le procédé comprend le recuit de premières amorces de lecture à des sites de liaison d'amorce sur le concatémère d'ADN, l'extension d'au moins certaines des premières amorces de lecture pour incorporer des dNTP ou des analogues de dNTP, ce qui permet de produire des premiers brins de lecture, chacun des dNTP ou des analogues de dNTP étant incorporé est identifié pour produire des premières lectures, la réalisation d'une MDA contrôlée par extension d'au moins certains des premiers brins de lecture avec une polymérase ayant une activité de déplacement de brin pour générer une pluralité de seconds brins, chaque second brin comprenant une partie qui est hybridée au concatémère d'ADN, et une branche simple brin non hybridée ; et à recuire des secondes amorces de lecture sur les branches monocaténaires de la pluralité de seconds brins, et à étendre les secondes amorces de lecture pour générer les secondes lectures.
Patent CA-3165450-A1 (CA)
Title: Appareil orthopedique d'immobilisation de l'epaule
Inventor: GILDERSLEEVE RICHARD E
IPC: A61F5/37
Filed: 2021-01-28
Abstract: Appareil d'immobilisation de l'épaule comprenant une écharpe d'avant-bras. L'écharpe d'avant-bras est conçue pour recevoir le coude, l'avant-bras et le poignet d'un premier bras d'un utilisateur et comprend un premier élément de fixation conçu pour fixer une sangle postérieure à une partie proximale adjacente au coude, un second élément de fixation conçu pour fixer une sangle antérieure à une partie distale adjacente au poignet, et un support de sangle controlatéral. Le support de sangle controlatéral comprend une sangle d'épaule circonférentielle conçue pour s'enrouler autour de l'épaule du second bras de l'utilisateur afin de former une ouverture sensiblement ellipsoïdale qui s'appuie contre une région pectorale, une région scapulaire et l'une d'une région axillaire ou d'une partie extérieure latérale de l'épaule du second bras de l'utilisateur. Les sangles postérieure et antérieure ont chacune des éléments de fixation pivotants accouplés de façon rotative aux parties postérieure et antérieure respectives de la sangle d'épaule circonférentielle. La présente invention concerne également des procédés associés.
Patent CA-3166231-A1 (CA)
Inventor: WHITE KEITH R
IPC: F24F13/02
Filed: 2022-06-30
Abstract: Flex duct systems have a flex duct having a wire-reinforced core and first and second hollow connector ends threaded to one each of ends of the wire-reinforced core. Each connector end has a plurality of locking tabs. A boot, a saddle trunk, or a linking connector each have a plurality of sleeves each protruding radially outward and positioned to releasably, attachably receive one of the plurality of locking tabs for a fluid tight connection therewith.
Patent CA-3167198-A1 (CA)
Inventor: Dong chenglong
IPC: E04F13/07
Filed: 2022-07-11
Abstract: A spliced wall panel comprises at least one layer of frame bodies stacked in sequence; the frame body is formed by splicing several boards sequentially, and buckles are provided at the joint of adjacent boards; inclined structures are oppositely arranged on both sides of the board, and a positioning protrusion and a positioning groove that fit each other are formed on the oppositely arranged inclined structures respectively; a horizontal mounting groove is formed on the top of the inner wall of the board, and a mating groove matching the mounting groove is formed on the outer wall at the bottom of the board; fitting blocks that match the buckles are formed on both sides of the outer wall of the board. The frame structure formed from multiple boards meets the requirements of the wall panel and can be stacked into a multi-layer frame structure based on actual needs.
Patent CA-3169987-A1 (CA)
Inventor: THIJSSEN STEPHAN
IPC: A61B5/145
Filed: 2021-03-26
Abstract: A hemodialysis system includes a hemodialysis machine and a blood monitoring system. The hemodialysis machine is configured to provide hemodialysis treatment to a patient, wherein the hemodialysis treatment includes circulating extracorporeal blood of the patient through an extracorporeal blood circuit. The blood monitoring system includes: a sensor device configured to measure a hematocrit value corresponding to the extracorporeal blood of the patient in the extracorporeal blood circuit; and at least one controller. The blood monitoring system is configured to communicate with an electronic health records (EHR) system over a communications network to obtain patient-specific mean corpuscular hemoglobin concentration (MCHC) data for the patient. The at least one controller is configured to determine a hemoglobin concentration value corresponding to the extracorporeal blood for the patient in the extracorporeal blood circuit using the measured hematocrit value and the patient-specific MCHC data for the patient.
Patent CA-3170154-A1 (CA)
Inventor: LE ZHENGYI
IPC: G06F17/00
Filed: 2022-08-11
Abstract: The present application relates to an anomalous data detecting method, and corresponding device, computer equipment, and storage medium. The method comprises: obtaining a target isolated tree, wherein the target isolated tree is a random one in a well-trained isolated forest, and the isolated forest includes plural isolated trees; obtaining data to be detected, determining a target node position of the data to be detected on the target isolated tree, not further splitting the data to be detected, directly assigning the data to be detected to the target node position, and obtaining a new target isolated tree; calculating a target isolated tree average depth;  calculating a target node depth of the target node position; determining an anomaly score value;  and determining any anomalous circumstance of the data to be detected. Use of this method enables enhancement of precision rate in the detection of anomalous data.