Patent SG-11201907208X-A (SG)
Title: Radiolabeled anti-lag3 antibodies for immuno-pet imaging
Inventor: KELLY MARCUS
IPC: C07K16/28
Filed: 2018-02-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 16 August 2018 (16.08.2018) WIP0 1 PCT 011101 V III °nolo VIII oimIE (10) International Publication Number WO 2018/148476 Al (51) International Patent Classification: C07K 16/28 (2006.01) CO7C 259/00 (2006.01) A61K 51/10 (2006.01) A61K 39/00 (2006.01) (21) International Application Number: PCT/US2018/017525 (22) International Filing Date: 09 February 2018 (09.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/457,287 10 February 2017 (10.02.2017) US (71) Applicant: REGENERON PHARMACEUTICALS, INC. [US/US]; 777 Old Saw Mill River Road, Tarrytown, New York 10591-6707 (US). (72) Inventors: KELLY, Marcus; c/o Regeneron Pharmaceu- ticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591 (US). MA, Dangshe; c/o Regeneron Pharma- ceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591 (US). OLSON, William; c/o Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tar- rytown, New York 10591 (US). TAVARE, Richard; c/o Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill Riv- er Road, Tarrytown, New York 10591 (US). THURSTON, Gavin; c/o Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591 (US). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) = (74) Agent: CROWLEY-WEBER, Cara L. et al.; Fisher- Broyles, LLP, 26844 E. Quarto Pl., Aurora, CO 80016 (US). = (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 1-1 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 71' TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). 71' 00 1-1 (54) Title: RADIOLABELED ANTI-LAG3 ANTIBODIES FOR IMMUNO-PET IMAGING (57) : Radiolabeled anti-LAG3 antibodies and their use in immuno-PET imaging are provided herein. Included are methods 0 of detecting the presence of LAG3 proteins in a patient or sample.