Patent SG-11201910066Q-A (SG)
Title: Antibodies recognizing tau
Inventor: BARBOUR ROBIN
IPC: A61K39/00
Filed: 2018-05-02
Abstract: WO 18/ 20 45 46 A3 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 November 2018 (08.11.2018) WIPO I PCT ill~~~~~~~~ 011101010VIIIOH olo oi olo Immoomi (10) International Publication Number WO 2018/204546 A3 (51) International Patent Classification: C07K 16/18 (2006.01) A61K 39/00 (2006.01) (21) International Application Number: PCT/US2018/030739 (22) International Filing Date: 02 May 2018 (02.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/500,427 02 May 2017 (02.05.2017) US 62/580,408 01 November 2017 (01.11.2017) US (71) Applicant: PROTHENA BIOSCIENCES LIMITED [IE/IE]; Adelphi Plaza, Upper George's Street, Dun Laoghaire Co. Dublin, A96 T927 (IE). (71) Applicants US only): BARBOUR, Robin [US/US]; 250 Normandy Lane, Walnut Creek, California 94598 (US). ALEXANDER, Svetlana [US/US]; 913 Hollenbeck Ave., Sunnyvale, California 94087 (US). RENZ, Mark E. [US/US]; 808 Murchison Dr., Millbrae, California 94030 (US). GAI, Shuning [US/US]; 1098 Solana Drive, Moun- tain View, California 94040 (US). NIJJAR, Tarlochan S. [US/US]; 712 Ironbark Court, Orinda, California 94563 (US). DOLAN, Philip James [US/US]; 622 Edgewater Blvd. #303, Foster City, California 94404 (US). (72) Inventor; and (71) Applicant: PAYNE, Philip [US/US]; 660 Santa Paula Av- enue, Sunnyvale, California 94085 (US). (72) Inventors: BARBOUR, Robin; 250 Normandy Lane, Wal- nut Creek, California 94598 (US). ALEXANDER, Svet- lana; 913 Hollenbeck Ave., Sunnyvale, California 94087 (US). RENZ, Mark E.; 808 Murchison Dr., Millbrae, Cal- ifornia 94030 (US). GAI, Shuning; 1098 Solana Drive, Mountain View, California 94040 (US). DOLAN, Philip James; 622 Edgewater Blvd. #303, Foster City, California 94404 (US). NIJJAR, Tarlochan S.; 712 Ironbark Court, Orinda, California 94563 (US). (74) Agent: SATHER, Susan et al.; Alston & Bird LLP, 101 South Tryon Street, Bank of America Plaza, Suite 4000, Charlotte, North Carolina 28280-4000 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: ANTIBODIES RECOGNIZING TAU In HASA (Ns-4a (57) : The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration. [Continued on next page] WO 2018/204546 A3 MIDEDIMOMOIDIONDERIO 010 IIIIIIIIII IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.17(i)) as to applicant's entitlement to apply for and be granted a patent (Rule 4.170) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) (88) Date of publication of the international search report: 13 December 2018 (13.12.2018)