baber/WOPTO huggingface dataset:
Patent NZ-626655-A (NZ)
Title: Door closer, particularly for glass doors
Inventor: BACCHETTI LUCIANO
IPC: E05F5/02
Filed: 2011-09-06
Abstract: A door closing hinge for a door, a glass door in particular, includes a box-like body 10 that can be anchored either to the door or the door frame, and a pin 20 with a longitudinal axis X that can be anchored to the other of the door or door frame, so that the pin and the box- like body can be rotated with respect to each other on the first axis between open and closed door positions. A closer 30 for the automatic return of the door from the open to the closed position includes a first cam element 31 interacting with a first plunger element 32 movable within the box-like body between a first compressed end position corresponding to the open door position and a first extended end position corresponding to the closed door position. A braking means 40 acts on the closing means for counteracting the action of the closing means, the braking means including a second cam element 41 interacting with a second plunger element 42 movable within the box- like body between a second compressed end position corresponding to the closed door position and a second extended end position corresponding to the open door position. The first and second plunger elements are slidably movable in a single operating chamber 50, the first and second cam elements 31 and 41 are unitary with the pin, the pin is interposed between the first and second plunger elements 32 and 42, the operating chamber 50 includes a working fluid, the first plunger element includes a substantially cylindrical first back portion and a first pushing head, the second plunger element includes a substantially cylindrical second back portion and a second front portion which includes a second pushing head, with the first and second back portions separating the operating chamber into first, second, and third adjacent variable volume compartments in reciprocal fluid communication. The first and third variable volume compartments are designed to have in correspondence with the closed door position respectively the maximum and minimum volume and in correspondence with the open door position respectively the minimum and maximum volume. The closing hinge includes a first counteracting elastic means (a coil spring) located in the first compartment, and the braking means includes second counteracting elastic means (a second coil spring) located in the third compartment, and both of the cam elements are located in the second compartment.
Patent NZ-628282-A (NZ)
Title: Rotavirus subunit vaccines and methods of making and use thereof
Inventor: BEY RUSSELL F
IPC: A61K39/15
Filed: 2013-02-14
Abstract: Disclosed is an immunological composition comprising: a) NSP4, VP4 and VP6 polypeptides; and b) a pharmaceutically or veterinary acceptable vehicle, diluent or excipient. Further disclosed is a method for producing the above composition comprising the steps of: (a) obtaining a biological sample from a non-human animal known or suspected of being infected with one or more types of rotavirus; (b) if infection status is not known, determining whether the animal is infected with rotavirus; (c) harvesting RNA from a biological sample previously obtained from the animal infected with the one or more type of rotavirus; (d) performing reverse transcriptase PCR using primers complementary to NSP4, VP4 and VP6 genes; (e) inserting the PCR product from step (d) into a suitable non-human expression vector; (f) placing the vector produced in step (e) into a suitable non-human host expression system; (g) harvesting the rotaviral polypeptides; and (h) adding to the rotaviral polypeptides any additional vaccine components, thereby producing the vaccine composition.
Patent NZ-629199-A (NZ)
Title: Pharmaceutical compositions comprising a solid dispersion of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
Inventor: DOKOU ELENI
IPC: A61K47/38
Filed: 2013-02-27
Abstract: The disclosure relates to pharmaceutical compositions containing a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating CFTR mediated disease in a pediatric patient employing the pharmaceutical composition, wherein the CFTR mediated disease is cystic fibrosis, COPD, emphysema, dry-eye disease or osteoporosis. Particularly disclosed is a pharmaceutical composition comprising: about 35 wt% of a solid dispersion by weight of the composition, wherein the dispersion comprises about 80 wt% by weight of the dispersion of substantially amorphous or amorphous Compound 1, wherein less than about 15% of Compound 1 is in crystalline form, about 19.5 wt% of hydroxylpropylmethylcellulose acetate succinate (HPMCAS) by weight of the dispersion, and about 0.5 wt% sodium lauryl sulfate (SLS) by weight of the dispersion; about 13.5 wt% of mannitol by weight of the composition; about 41 wt% of lactose by weight of the composition; about 2 wt% of sucralose by weight of the composition; about 6 wt% of croscarmellose sodium by weight of the composition; about 1 wt% of colloidal silicon dioxide by weight of the composition; and about 1.5 wt% of magnesium stearate by weight of the composition.
Patent NZ-706266-A (NZ)
Title: Process for the preparation of 2-trifluoromethyl isonicotinic acid and esters
Inventor: TRUSSARDI RENé
IPC: C07D213/84
Filed: 2013-11-13
Abstract: The invention relates to a novel process for the preparation of 2- trifluoromethyl isonicotinic acid and esters of the formula I which involves a palladium catalysed carbonylation or cyanation step wherein R1 is hydrogen or Q1-6-alkyl. The 2-trifluoromethyl isonicotinic acid and esters of the formula I are versatile intermediates for the preparation of active pharmaceutical and agrochemical agents such as for instance TAAR 1 agonists of the formula III.
Patent NZ-709285-A (NZ)
Title: A multi-fit clip
Inventor: ANDREW LEO HAYNES
IPC: F16L3/137
Filed: 2014-06-20
Abstract: Typical pipe or conduit systems include proprietary clips for securing the pipe or conduit in place. The clips are typically specific to the diameter of conduit being installed. An installer must carry sufficient clips to properly secure all of the different conduit or pipe sizes that he may be required to install. It is an object of the present invention to provide a clip for securing an item relative to a support which goes some way toward overcoming these disadvantages or which will at least provide the industry with a useful choice. This invention relates to a clip, for securing a portion of a long thin item such as a cable or pipe. The clip comprises of a cradle portion for receiving a surface of an item to be secured, a fixing portion with at least one formation extending to be securable to a support, and a flexible member extending from a location at or adjacent an end of the cradle portion. The flexible member has a free end and formations at or near the free end to engage with other formations fixed in relation to the cradle portion. In use, the cradle portion and the flexible member define an enclosing loop, such that the flexible member may hold an item against the cradle. An outward surface of the flexible member includes ribs, and one or more of the ribs, when in association with said cradle, urges the formations of the flexible member into greater engagement in a socket of the cradle.
Patent NZ-710511-A (NZ)
Title: Cleats, cleated sole structures, molds, and molding methods for in-molding articles
Inventor: CURL DARIEN
IPC: B29D35/12
Filed: 2014-02-05
Abstract: Conventional golf shoes and other articles of footwear often include cleat structures or other traction enhancing elements to improve traction and provide a stable base for activities performed by the wearer. Many cleats of this type include a threaded connector or a turnbuckle type engagement structure to allow the cleat to be releasably engaged with a footwear sole structure. While useful to releasably engage the cleat with the shoe, such connector structures have certain disadvantages. For example, the treaded connector or turnbuckle type engagement structures typically extend toward the bottom (plantar) surface of the wearer’s foot. Therefore, when the wearer stands and walks on the shoe, distinct high pressure points often can be felt underfoot, which lead to discomfort and/or fatigue, particularly after walking in the shoes for 18 or more holes of golf (often over terrain of varying slope and hardness). Cushioning elements, rigid plates, or other pressure moderator or force dispersing structures may be incorporated into the footwear construction in an effort to reduce the point loading and/or pressure forces experienced by the wearer. Such structures, however, tend to increase the height of the shoe and/or reduce the flexibility and/or natural motion feel of the shoe. Many golfers find these features to be disadvantageous. Additionally, the releasable connection between cleats and the sole structure may cause the cleat elements to loosen and become disengaged from the shoe, often without the wearer immediately knowing. Such unintended loss of cleats can adversely impact traction and potentially damage golf course mowing or maintenance equipment. The disclosure of the present application aims to overcome or ameliorate one or more of the above identified problems by providing cleat structures which include: (a) a cleat component and (b) a cleat base engaged with the cleat component. The cleat is formed in a manner such that it does not include a threaded connector structure or a turnbuckle connector structure, but it is engaged with a footwear sole structure by an “in-molded” connection (e.g., with material of the sole flowing through perimeter openings in the cleat base during a molding process for producing the sole). By eliminating threaded or turnbuckle connector structures, the bottom surface of the cleats may be made planar, substantially planar, and/or smoothly contoured. These features help avoid or reduce point load forces at the bottom of the wearer’s foot and/or help avoid or reduce the need for moderator plates and/or thick midsole material and midsole height to moderate the feel of the cleat.
Patent NZ-710556-A (NZ)
Title: Multiple-compartment container
Inventor: LESPERANCE NICOLE
IPC: B65D77/08
Filed: 2014-03-10
Abstract: Conventional containers for food products suffer from the disadvantage that the cover often fails to adequately separate the first compartment from the second compartment. The lack of an airtight seal between compartments can result in moisture from one compartment undesirably equilibrating into another compartment. An embodiment of the present disclosure is a multiple-compartment container including an upper rim defining an upper plane, a lower rim defining a lower plane, a perimeter wall connecting the upper rim to the lower rim, and at least one internal wall extending upward from the lower plane and dividing the container into multiple compartments. The perimeter wall forms an outer surface of the container and an upper edge of the internal wall is an uppermost feature of the container. Advantageously, the multiple-compartment configuration allows for packaging food products or other items having different moisture levels or moisture requirements. An exemplary embodiment of the present disclosure is a multiple compartment container for use with food products having different densities or moisture levels, and includes a dividing wall that separates the container into at least two compartments.
Patent NZ-712159-A (NZ)
Title: Antiemetic extended release solid dosage forms
Inventor: FATHI REZA
IPC: A61K31/4178
Filed: 2014-03-14
Abstract: A solid oral dosage form includes a core comprising a non-ionic polymer matrix, a first amount of a first antiemetic drug or a pharmaceutically acceptable salt thereof dispersed within the matrix, and a salt dispersed within the matrix; a first seal coat of a non-ionic polymer matrix surrounding the core; and an immediate release drug layer surrounding the first seal coat, wherein the immediate release drug layer comprises a non-ionic polymer and a second amount of a second antiemetic drug or a pharmaceutically acceptable salt thereof dispersed therein, wherein the drug layer is sufficiently designed to release the second amount of the antiemetic drug over a period of at least 1 hour, wherein the solid oral dosage form is sufficiently designed to release the first amount of the first antiemetic drug and the second amount of the second antiemetic drug over a minimum period of 16 hours.
Patent NZ-714797-A (NZ)
Title: Primary carboxamides as btk inhibitors
Inventor: VASUDEVAN ANIL
IPC: A61K31/4545
Filed: 2014-06-26
Abstract: The invention provides carboxamide compounds of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions, including rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis, Crohn’s disease, inflammatory bowel disease, ulcerative colitis, psoriatic arthritis, psoriasis, ankylosing spondylitis, interstitial cystitis, asthma, systemic lupus erythematosus, lupus nephritis, B cell chronic lymphocytic lymphoma, multiple sclerosis, chronic lymphocytic leukemia, small lymphocytic lymphoma, mantle cell lymphoma, B-cell non-Hodgkin’s lymphoma, activated B-celllike diffuse large B-cell, lymphoma, multiple myeloma, diffuse large B-celllymphoma, follicular lymphoma, hairy cell leukemia or Lymphoblastic lymphoma.
Patent NZ-715776-A (NZ)
Title: Polymorph of syk inhibitors
Inventor: STEFANIDIS DIMITRIOS
IPC: C07D487/04
Filed: 2014-07-29
Abstract: Polymorphs of a bis-mesylate salt of a compound of Formula (I): or a hydrate thereof, are provided. The bis-mesylate salt may also be depicted as a compound of Formula (IA): Provided herein are also compositions thereof, methods for their preparation and methods for such polymorphs.
Patent NZ-719036-A (NZ)
Title: Anti-pdl1 antibody formulations
Inventor: YANG YING
IPC: C07K16/28
Filed: 2014-09-26
Abstract: The invention provides stable aqueous pharmaceutical formulations comprising an anti-PDL1 antibody. The invention also provides methods for making such formulations and methods of using such formulations. In a particular embodiment, the stable aqueous formulation comprising an anti-PDL1 monoclonal antibody in a concentration of 40 mg/ml to 125 mg/ml, histidine acetate or sodium acetate in a concentration of 15 mM to 25 mM, sucrose in a concentration of 60 mM to 240 mM, polysorbate in a concentration of 0.005% (w/v) to 0.06% (w/v), and pH 5.0 to 6.3; wherein said monoclonal antibody comprises a light chain variable region comprising the amino acid sequence of SEQ ID NO:7, and a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:32; and wherein said monoclonal antibody is a humanized IgG1 antibody.
Patent NZ-723911-A (NZ)
Title: Tagged scale inhibiting polymer compositions and methods of inhibiting scale formation
Inventor: TOIVONEN SUSANNA
IPC: C08F226/00
Filed: 2013-07-10
Abstract: Disclosed are scale-inhibiting polymers comprising one or more scale-inhibiting units and one or more tagging units, wherein each tagging unit is formed from a compound of Formula I, II, III, or IV, or a salt, hydrate, salt hydrate, stereoisomer, dehydrate thereof. Scale-inhibiting compositions comprising the scale-inhibiting polymers, processes for determining a concentration of a scale-inhibiting polymer for inhibiting scale formation, and methods for preventing or controlling scale formation in systems comprising fluid circulation with the scale-inhibiting polymers are also disclosed herein.
Patent NZ-728708-A (NZ)
Title: Disposable diaper and cushion sheet
Inventor: TASHIRO IZUMI
IPC: A61F13/49
Filed: 2015-08-05
Abstract: [Problem] To improve the ventilation properties of a sheet used in a flute structure. [Solution] This disposable diaper has formed therein, on at least one of a front part and a rear part, a cushion part (40). In the cushion part (40), in a state where a waist expansion member (43) is stretched in the width direction of the diaper, the member is sandwiched and secured between an inner sheet (41) and an outer sheet (42). In the cushion part (40), a cushion forming sheet (44) overlaps one or both of the inner sheet (41) and the outer sheet (42), and is intermittently joined thereto so that in the width direction joining portions (51) and non-joining portions (52) are alternatingly continuous. Formed in the cushion forming sheet (44) are a plurality of openings (60) or depressions that are grouped into row groups (R) and column groups (C). A continuous line (A) links the plurality of openings (60) or depressions which belong to the column group (C), and the line is inclined at a prescribed angle (θ) with respect to a reference line (F) that extends in the longitudinal direction.
Patent NZ-731599-A (NZ)
Title: Phorbol ester compositions and methods for treating or reducing the duration of cytopenia
Inventor: HAN ZHENG TAO
IPC: A61P7/00
Filed: 2015-11-03
Abstract: Methods and compositions containing a phorbol ester of Formula I or a derivative thereof in combination with G-CSF (Granulocyte-colony stimulating factor) or in combination with EPO (erythropoetin), are provided for the treatment of cytopenia in mammalian subjects. The compositions and methods also reduce the duration of cytopenia such as neutropenia, thrombocytopenia, and/or anemia.
Patent NZ-735973-A (NZ)
Title: Compositions and methods for treating anemia
Inventor: SMITH ALEXANDER
IPC: A61K31/16
Filed: 2016-03-31
Abstract: Provided herein are specific doses of, and dosing regimens for, using a HIF prolyl hydroxylase inhibitor in treating or preventing anemia, such as anemia secondary to or associated with chronic kidney disease, anemia secondary to or associated with non-dialysis dependent chronic kidney disease anemia associated with or resulting from chemotherapy, or anemia associated with AIDS.
Patent NZ-739876-A (NZ)
Title: Process for preparing parp inhibitor, crystalline forms, and uses thereof
Inventor: REN BO
IPC: C07D487/22
Filed: 2016-08-22
Abstract: Provided are a process for preparing a Parp1/2 inhibitor, i.e., (R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one (hereinafter referred to as Compound A), crystalline forms (polymorphs) of Compound A or hydrate or solvate thereof, methods for preparing the crystalline forms, and the use thereof.
Patent NZ-740685-A (NZ)
Title: Centrifugal separator with intermittent discharge of heavy phase
Inventor: Pitkämäki Jouko
IPC: B04B1/18
Filed: 2016-10-11
Abstract: A centrifugal separator comprises a casing which delimits a space (17) which is sealed off from and having an under pressure in relation to the surroundings,by at least one seal; and in which a rotor (5) is arranged for rotation around a rotational axis (x) and forming within itself a separation space (7), and in which separation space (7) centrifugal separation of at least one higher density component and at least one lower density component from a fluid takes place during operation, into which rotor (5) at least one inlet (9) extends for introducing said fluid to the separation space (7), and from which rotor (5) at least one first outlet (12) extends for discharge of at least one component separated from the fluid during operation, and wherein the rotor comprises at least one second outlet (16) extending from a portion of the separation space to the space (17) for discharge of at least one higher density component separated from the fluid during operation, and wherein said second outlet (16) is arranged for intermittent discharge by an intermittent discharge system and one of said seals is formed by said intermittent discharge system. The invention aims to reduce energy consumption in centrifugal separators.
Patent NZ-755166-A (NZ)
Title: Biofilm disrupting composition for use on chronic wounds
Inventor: GLASBEY TREVOR
IPC: A61K31/496
Filed: 2017-12-21
Abstract: A biofilm disrupting composition for use on chronic wounds comprising (i) at least one biologically acceptable thiol based antioxidant(ii) at least one biofilm disruptor and (iii) at least one biocide. Also disclosed is a process of preparing the composition. Also disclosed is the use of the composition for the manufacture of a medicament for the treatment of a chronic wound, and a method of treating a chronic wound in a patient comprising administering the biofilm disrupting composition.
Patent NZ-761478-A (NZ)
Title: Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
Inventor: BIGAL MARCELO
IPC: A61K39/395
Filed: 2015-03-20
Abstract: The invention features methods for preventing or treating CGRP associated disorders, in particular migraine headache by administering an anti-CGRP antagonist antibody at a dose of 675mg once every three months.
Patent NZ-777096-A (NZ)
Title: Antimicrobial gas releasing agents and systems and methods for using the same
Inventor: FREEDMAN JONATHAN R
IPC: A01N25/10
Filed: 2019-11-12
Abstract: Disclosed are antimicrobial releasing agents, methods of preparing the antimicrobial releasing agents, and entrained polymers containing antimicrobial releasing agents. The antimicrobial releasing agent is prepared with an acidified hydrophilic material with a pH below 3.5 as a carrier, an active compound, and a trigger. The entrained polymer of the invention releases an antimicrobial agent in gas form, such as ClO2, optionally over a range of concentration from 150 ppm to 1800 ppm per gram of the entrained polymer under certain tested conditions.
Patent PT-106709-A (PT)
Title: Emulsões aquosas reativas para revestimentos compósitos
Inventor: GONÇALVES SUSANA PAULA SANTOS CARVALHO PIÇARRA
IPC: C09D1/02
Filed: 2012-12-21
Abstract: A PRESENTE INVENÇÃO REFERE-SE À PRODUÇÃO DE EMULSÕES AQUOSAS REATIVAS, CONSTITUÍDAS POR MICRO OU NANOPARTÍCULAS DE CADEIAS ORGÂNICAS COM ALCÓXIDOS METÁLICOS NA FORMA MONOMÉRICA ENCAPSULADOS NO SEU INTERIOR, DESTINADAS À PRODUÇÃO DE REVESTIMENTOS COMPÓSITOS PARA APLICAÇÕES COMO TINTAS E VERNIZES. TRATA-SE DE EMULSÕES REATIVAS, NO SENTIDO EM QUE A FORMAÇÃO DE CADEIAS INORGÂNICAS E DE RETICULAÇÕES SÓ OCORRE NA ALTURA DESEJADA, APÓS A APLICAÇÃO E SECAGEM DA EMULSÃO SOBRE A SUPERFÍCIE A TRATAR. O REVESTIMENTO FINAL APRESENTA UMA ESTRUTURA DE REDE COMPÓSITA, FORMADA POR CADEIAS ORGÂNICAS E INORGÂNICAS RETICULADAS ENTRE SI, O QUE LHE CONFERE, POR UM LADO, UMA ELEVADA RESISTÊNCIA MECÂNICA, À ABRASÃO E AO ATAQUE QUÍMICO E, POR OUTRO, UMA BOA MALEABILIDADE, APRESENTANDO RESISTÊNCIA AO CHOQUE.
Patent RU-94003002-A (RU)
Inventor: STEKOL NIKOV L I
IPC: A61K31/215
Filed: 1994-01-28
Abstract: FIELD: medicine. SUBSTANCE: invention relates to prolongation of thymolol therapeutic action that is one of noncardioselective β---adrenoblocking agent used for glaucoma treatment. Method involves the use of thymolol in combination with hyaluronic acid. Thymolol and hyaluronic acid were taken at mass ratio 1:(2-4) at solution concentration containing this mixture 0.01-0.05%. EFFECT: decreased thymolol dose, prolonged therapeutic action with respect to intraocular pressure decrease.