Patent SG-11201408793X-A (SG)
Title: Methods related to real-time cancer diagnostics at endoscopy utilizing fiber-optic raman spectroscopy
Inventor: HUANG ZHIWEI
IPC: A61B6/00
Filed: 2013-07-02
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 9 January 2014 (09.01.2014) WIPOIPCT (10) International Publication Number WO 2014/007759 A1 (51) International Patent Classification: G01N21/65 (2006.01) A61B 6/00 (2006.01) A61B 5/00 (2006.01) G01N33/574 (2006.01) G01J3/44 (2006.01) (21) International Application Number: PCT/SG2013/000273 (22) International Filing Date: 2 July 2013 (02.07.2013) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 61/667,384 2 July 2012 (02.07.2012) US 1307338.2 23 April 2013 (23.04.2013) GB (71) Applicant: NATIONAL UNIVERSITY OF SINGA­ PORE [SG/SG]; 21 Lower Kent Ridge Road, Singapore 119077 (SG). (72) Inventors: HUANG, Zhiwei; c/o National University of Singapore, Faculty of Engineering, Department of Bioen- gineering, 21 Lower Kent Ridge Road, Singapore 119077 (SG). HO, Khek Yu; c/o National University of Singapore, Yong Loo Lin School of Medicine, Department of Medi­ cine, 21 Lower Kent Ridge Road, Singapore 119077 (SG). BERGHOLT, Mads Sylvest; c/o National University of Singapore, Faculty of Engineering, Department of Bioen- gineering, 21 Lower Kent Ridge Road, Singapore 119077 (SG). ZHENG, Wei; c/o National University of Singapore, Faculty of Engineering, Department of Bioengineering, 21 Lower Kent Ridge Road, Singapore 119077 (SG). YEOH, Khay Guan; c/o National University of Singapore, Yong Loo Lin School of Medicine, Department of Medicine, 21 Lower Kent Ridge Road, Singapore 119077 (SG). DURAIPANDIAN, Shiyamala; c/o National University of Singapore, Faculty of Engineering, Department of Bioen­ gineering, 21 Lower Kent Ridge Road, Singapore 119077 (SG). (74) Agent: AMICA LAW LLC; 30 Raffles Place, #18-03/04 Chevron House, Singapore 048622 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. [Continued on next page] (54) Title: METHODS RELATED TO REAL-TIME CANCER DIAGNOSTICS AT ENDOSCOPY UTILIZING FIBER-OPTIC RAMAN SPECTROSCOPY (57) Abstract: A method of achieving instrument inde­ pendent measurements for quantitative analysis of fiber­ optic Raman spectroscope system, the system compris­ ing laser source, spectroscope and a a a fiber optic probe to transmit light from the laser source to a target and re­ turn scattered light to the spectroscope, the method com­ prising transmitting light from the laser source to a standard target having a known spectrum, recording a calibration spectrum of the scattered light from the standard target, comparing the known spectrum and the calibration system and generating a probe and/or probe- system transfer function, and storing the transfer func­ tion. Further provided is a method of performing real­ time diagnostic Raman spectroscopy optionally in com­ bination with the other disclosed methods. 0\ i> i> o o [HuHnraaikm Distal tip of endoscope .L Epitfteflum Stroma WO 2014/007759 A11II llll IIII III III III llll III III Hill Hill II lllll llll 111 mill llll 111 llll (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17 (iv)) Published: — with international search report (Art. 21(3))