Patent SG-11201408787P-A (SG)
Title: Enhancing activity of car t cells by co-introducing a bispecific antibody
Inventor: JUNE CARL H
IPC: C07K14/05
Filed: 2013-07-12
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 16 January 2014 (16.01.2014) WIPOIPCT (10) International Publication Number WO 2014/011988 A3 (51) International Patent Classification: C07K14/05 ( 2006.01) (21) International Application Number: PCT/US2013/050275 (22) International Filing Date: 12 July 2013 (12.07.2013) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 61/671,535 13 July 2012 (13.07.2012) US (71) Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; Center For Technology Transfer, 3160 Chestnut Street, Suite 200, Philadelphia, PA 19104-6283 (US). (72) Inventors: JUNE, Carl, H.; 409 Baird Road, Merion Sta­ tion, PA 19066 (US). ZHAO, Yangbing; 23 Doncaster Rd„ Cherry Hill, NJ 08003 (US). LIU, Xiaojun; 801 Yale Avenue, Apt. 809, Swarthmore, PA 19081 (US). (74) Agents: NGUYEN, Quang D. et al.; Riverside Law, LLP, 300 Four Falls Corporate Center, Suite 710, 300 Consho- hocken State Road, West Conshohocken, PA 19428 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. [Continued on next page] (54) Title: ENHANCING ACTIVITY OF CAR T CELLS BY CO-INTRODUCING A BISPECIFIC ANTIBODY CMS VR CtSSVtJ CS3VH !)} (57) Abstract: The present invention provides compositions and methods for treating cancer in human. The invention includes administering a a T cell, genetically modified to express a chimeric antigen receptor (CAR), a bispecific antibody, or a combination thereof to a subject. The CAR and bispecific antibody of the invention can comprise a human antibody, a hu­ manized antibody, or antigen-binding fragments thereof. pGEM-2304(CD39)B62.64A ; CDSMse&IM f P®lyAT«1 pt»H<?8(Ct>»5-8BZ.64A w» < oo 00 0\ *1 ; Figure 1 WO 2014/011988 A3 III llll IIII III III Hill III III III Hill lllll lllll lllll llll 111 mill llll 111 llll (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, — TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (88) Date of publication of the international search report: 13 March 2014