baber/WOPTO huggingface dataset:
Patent IL-181663-A0 (IL)
Title: Substituted 4-phenyltetrahydroisoquinolines, method for the production thereof, their use as a medicament, and a medicament containing them
Filed: 2007-03-01
Abstract: The present invention relates to substituted 4-phenyltetrahydroisoquinoline compounds of the structure of formula I and pharmaceutical compositions comprising them wherein the R groups are herein defined. These are excellent inhibitors of the sodium-hydrogen exchanger (NHE), in particular of the sodium-hydrogen exchanger of subtype 3 (NHE3). As such these compounds are useful in the treatment of various disorders of the renal and respiratory systems such as acute or chronic renal failure, pulmonary complications, biliary function disorders, respiratory disorders such as snoring or sleep apneas and cardiovascular/central nervous system disorders such as stroke. More specifically, the present invention relates to substituted 4-phenyl-tetrahydroisoquinolines, derivatives thereof and compositions containing them formulated in combination with other compounds which also regulate the intracellular pH environment such as inhibitors of carbonic anhydrase and inhibitors of the transport systems that carry bicarbonate ions, such as of the sodium-bicarbonate co-transporter (NBC) or the sodium-dependent chloride-bicarbonate exchanger.
Patent IL-195194-A0 (IL)
Title: Thermostable dna polymerase of the archaeal ampullavirus abv and its applications
Filed: 2008-11-10
Abstract: The present invention is directed to the thermostable DNA polymerase protein of the archaeal ampullavirus ABV (Acidianus Bottle-shaped virus) and the nucleic acid encoding said DNA polymerase. The invention also relates to method of synthesizing, amplifying or sequencing nucleic acid implementing said DNA polymerase protein and kit or apparatus comprising said DNA polymerase protein.
Patent RO-125606-A0 (RO)
Title: Plasticizing composite mixture made of heavy alloys and process for making the same
Inventor: INVENTATORI NEDECLARAŢI
IPC: C22C27/04
Filed: 2010-02-16
Abstract: The invention relates to a pulverous composite mixture, consisting of heavy alloys of the W-Cu system, and to a process for making the same. According to the invention, the pulverous composite mixture, characterized in that there is achieved a homogenous mixture between a quantity of 87-90% g of W and 13-10% g of Cu, mechanically alloyed, and a quantity of minimum 6-10%, by weight, of a multicomponent binder having the following composition: paraffin = 50-60%, bee wax = 5-10%, polyethylene = 25-45%, stearic acid = 0-5% and paraffin A = 2%, the percentage being expressed by weight. According to the invention, the process consists in making a mixture of metal powders, by grinding in ball mills of high energy, the quantities of 87-90% g of W and 13-10% g of Cu, for 30-45 h, with the grinding rate ranging between 300-700 rot/min, with an enclosure filling level of 25% and with the ball/metal ratio of 3/1, there resulting powders with a granulation d = 5-50 μ m, after which the metal powder is mixed in a mixer with a multicomponent binder, with the waxes/polymers ratio = 0.74-2.09, the paraffin/bee wax ratio = 1.0-6.0 and an addition of 2% stearic acid, the mixing process having the following parameters: the rotation speed of the mixer arms ranges between 20-60 rot/min, the mixture temperature in the mixer is 120-140°C, and the mixing time is 3-6 h.
Patent RO-126097-A0 (RO)
Title: Electrochemical process for the synthesis of anatase tiofrom ionic liquid based on choline chloride
Inventor: ANICĂI LIANA JEANINA
IPC: B01J21/06
Filed: 2010-09-14
Abstract: The invention relates to an electrochemical process for preparing TiOas powder comprising nanocrystalline particles, said process using ionic liquids based on choline chloride as electrolyte, the titanium dioxide being used as semiconductor material in photoelectrical, photocatalytical and optical fields. According to the invention, the process consists in electrochemically dissolving a titanium anode under the action of a direct current of 2...5 A/dmfor 2...6 hours at a temperature in the range of 40...70°C in an electrolyte comprising eutectic mixtures of choline chloride and ethylene glycol in a molar ratio of 1:1 or choline chloride and urea in a molar ratio of 1:2, whereto there are added 0.004...0.006 M of tetrabutylammonium bromide and ethanol in a volume ratio of 2:1 and 1:1 as compared to the ionic liquid, thereby resulting an intermediary product which, after being separated from the reaction medium, is washed with ethanol, dried and calcinated at a temperature of 500°C, there resulting finally a TiOpowder as crystalline anatase with an anode formation output in the range of 85...97%, with particles sizes of 10...20 nm, with a specific surface of 60...90 m/g having an average pore diameter of 3.8 nm and a pore volume of 0.2 cm/g, the absorption in the visible light range having a maximum of 525 nm and a photocatalytic degradation efficiency of pollutant organic/inorganic compounds of over 90%.
Patent RO-131887-A0 (RO)
Title: Temporary modular road system
Inventor: VOICU CĂTĂLIN DANIEL
IPC: E04D15/04
Filed: 2016-12-15
Abstract: The invention relates to a temporary modular road system relating to an assembly of interconnecting elements meant to be used for building temporary roads with multiple destinations, using components on any logistic support, earth, sand, to be used as a passage-way for persons and equipments or for organizing events, for storing spaces or parking spaces. According to the invention, the modular road system comprises a module of bridges which has an attachment system with 4 ends, a female-type end and a male-type end, where either another plate, or the access ramp may be fixed, along the plate there being attachment systems on either side thereof, where the attachment comprises two elastic clamps encapsulating a cylinder and some stoppers, to prevent excessive sliding, and, for detaching two plates, the plate to be detached needs to be lifted at more than 70° above the ground, the so-formed system having two essential properties, namely not allowing the excessive sliding, so that two plates attached this way will not get loose, and they are not rigid, they allowing a certain sliding, so that they absorb impact energy, which is important in any situation, even if it is used by dancers and sportsmen, for instance, and the multiple-angled access ramps allow easy access and, at the same time, the angles act as skid-proof means, preventing the slippage of the vehicle wheels or the persons going up and down this system.
Patent RO-134480-A0 (RO)
Title: Apparatus and method for actuating human hand fingers using a hybrid system with soft actuators for performing exercises of occupational therapy and medical rehabilitation after a stroke
Inventor: BIROUAŞ IONUŢ-FLAVIU
IPC: A63B23/16
Filed: 2020-06-25
Abstract: The invention relates to an apparatus such as a robotic orthosis and to a method for actuating the human fingers, for performing exercises of occupational therapy and medical rehabilitation, which are essential for regaining the ability to move of the human hand after a medical condition such as a stroke. According to the invention, the apparatus consists of five subassemblies (1 ... 5) each containing a set of soft actuators placed above the finger joints, the subassemblies (1 ... 5) being made in two embodiments depending on the number of finger joints, namely: the subassemblies (1 ... 4) having the embodiment (6) with three degrees of mobility and the subassembly (5) having the embodiment (7) with two degrees of mobility, where five individually independently controlled air pipes (8) actuate each finger, the five subassemblies (1 ... 5) being mounted on a fixing piece (9), which, in its turn, is fastened by two supports (10) located in the metacarpal area of the patient's hand, each subassembly (1 ... 5) consists of four rigid parts (11 ... 14) and one part (15) made of soft material with hyperelastic properties, said part (15) having three areas (16, 17 and 18) which have the role of soft actuators, the embodiment (7) has only two areas (96 and 97) which have the role of soft actuators. The claimed method consists in introducing the patient's fingers into the apparatus and automatically performing the fingers flexion and extension exercises by introducing air into the expansion chambers or depressurizing the expansion chambers of the apparatus.
Patent RO-135888-A0 (RO)
Title: Turbine driven by water, steam, compressed air, hydraulic oil
Inventor: ROŞCA DORU
IPC: F03B1/00
Filed: 2022-03-25
Abstract: The invention relates to a turbine driven by water, steam, compressed air or hydraulic oil to be used for producing electricity and for heating family or industrial spaces or as a hydraulic motor. According to the invention, the turbine consists of two or three arms (3) of medium height, wherein a working fluid enters through an access path (1) and exits through some outlet holes (4), achieving a high rotational speed by means of bearings or bearing boxes (2).
Patent RO-137108-A0 (RO)
Title: Surface-active non-ionic copolymer-amphoteric structures, synthesis, characterization
Inventor: JIANU IONEL-CĂLIN
IPC: C07D213/18
Filed: 2022-07-19
Abstract: The invention relates to amphoteric non-ionic N-alkyl R-2-[ β-(p)-nonylphenylhomopolyethyleneoxy-heteropolypropyleneoxy-ethyl]lutidinium chloride (4,6-dimethylpyridinium) sulfonated alkaline and ethanolammonium (mono-, di-, tri-), derivatives having colloidal characteristics. According to the invention, the derivatives are represented by the structural formula I, where p symbolizes the para isomer, n=3-18, m=3-18, R is a hydrocarbon radical, selected from CH3 and C18H37, M is an alkali and/or ethanolammonium cation.
Patent AP-2001002252-A0 (AP)
Title: Monoamine reuptake inhibitors for treatment of CNS disorders.
Inventor: ELLIOTT MARK LEONARD
IPC: C07C255/59
Filed: 2000-02-02
Abstract: The present invention relates to compounds that are a useful exhibit activity as serotonin, norepinephrine and dopamine reuptake inhibitors, and their phamaceutically acceptable salts, and their use in the treatment of central nervous system and other disorders.
Patent MC-1990-A1 (MC)
Inventor: MICHAEL KLAUS
IPC: C07C235/44
Filed: 1988-11-02
Abstract: Compounds of the general formula 
<IMAGE>
 in which
 R<1> denotes hydroxyl, lower alkoxy, amino, mono- or di-lower alkylamino;
 R<2> denotes hydrogen, alkyl, alkoxy or halogen;
 R<3>, R<4>, R<5>, R<6>, R<1><1> and R<1><2> independently of one another denote hydrogen or lower alkyl;
 R<3> and R<5> together denote a methylene or hydroxymethylene group;
 R<7>, R<8>, R<9> and R<1><0> denote hydrogen or lower alkyl; or
 R<1><1> and R<1><2> together denote an oxo group or spirocyclo-lower alkyl; or R<1><1> denotes hydrogen and R<1><2> denotes hydroxyl or acetoxy; and one of the radicals R<1><3> and R<1><4> denotes hydrogen and the other denotes lower alkyl or trifluoromethyl,
 and physiologically tolerable salts of carboxylic acids of the formula I can be used as medicines, in particular for the treatment of neoplasias, acne and psoriasis. The novel compounds can be prepared by synthesis of the C(R<1><3>)=C(R<1><4>) double bond according to Wittig from an appropriate bicyclic and an appropriate monocyclic component and, if appropriate, subsequent modification of functional groups.
Patent LU-83343-A1 (LU)
Inventor: TROUYEZ G
IPC: A61K39/002
Filed: 1981-05-06
Abstract: The invention relates to a process for obtaining preparations of toxoplasmas, improved for the diagnosis of toxoplasmosis by direct agglutination, said process comprising, in a first step, the inoculation in mice of a mixture of toxoplasmas and of sarcomatous cells, in a second step the inoculation in other mice of a mixture of sarcomatous cells infected with toxoplasmas coming from the mice of the first step and of non-infected sarcomatous cells, and finally the collection of the ascitic exsudate of these latter mice from 48 to 72 hours after inoculation.
Patent MA-22593-A1 (MA)
Inventor: DE ALMEIDA JOAO
IPC: A23L7/113
Filed: 1992-07-15
Abstract: A moist blend of cereals having a solids content of at least 70% by weight is processed by extrusion cooking, wherein a compressed gas is injected into the blend at the end of the cooking stage, before the extrusion stage, in the last part of the extrusion cooking apparatus close to the die. <IMAGE>
Patent MA-25305-A1 (MA)
Inventor: GAGLIARDI LEO
IPC: C11D1/72
Filed: 2001-05-09
Abstract: The present invention provides a composition in the form of an aqueous emulsion comprising a diacyl peroxide and a surfactant system.
Patent MA-26964-A1 (MA)
Title: Association d'agonistes de gaba et d'inhibiteurs de sorbitol-deshydrogenase.
Inventor: MYLARI BANAVARA LAKSHMAN
IPC: A61K38/08
Filed: 2003-05-20
Abstract: Société dite : PFIZER PRODUCTS INC. REVENDICATION DE PRIORITES US 30 Novembre 2000 60/250,069 Voir en annexe le titre de l'invention et le texte de l'abrégé Association d'agonistes de GABA et d'inhibiteurs de sorbitol-déshydrogénase L'invention concerne des compositions pharma??ceutiques comprenant des associations d'un agoniste de GABA, d'un de ses précurseurs médicamenteux ou d'un sel pharmaceutiquement acceptable dudit agoniste de GABA ou dudit précurseur médicamenteux, et d'un SDI, d'un de ses précurseurs médicamenteux, ou d'un sel pharmaceutiquement acceptable dudit SDI ou dudit précurseur médicamenteux, des kits contenant ces associations, et des méthodes d'utilisation de ces associations pour le traitement de mammifères, y compris l'homme, souffrant de complications diabétiques, telles que la neuropathie diabétique, la néphropathie diabétique, la myocardiopathie diabétique, la rétinopathie diabétique, la microangiopathie diabétique, la macroangiopathie diabétique, les catarates ou les ulcères des pieds. Application : utilisation des compositions pour le traitement des complications du diabète chez des mammifères, y compris l'homme.
Patent MA-27444-A1 (MA)
Title: Derives d'isothiazole et d'isoxazole nouveaux servant d'inhibiteurs du facteur de croissance transformant (tgf)
Inventor: MUNCHHOF MICHAEL JOHN
IPC: C07D471/04
Filed: 2005-03-18
Abstract: Société dite: PFIZER PRODUCTS INC. REVENDICATION DE PRIORITES US 18 Septembre 2002 60/412,131 US 2 Juillet 2003 60/484,580 Voir en annexe le titre de l'invention et le texte de l'abrégé Dérivés disothiazole et d'isoxazole nouveaux servant d'inhibiteurs du facteur de croissance transformant (TGF) Des dérivés disothiazole et d'isoxazole nouveaux, y compris leurs dérivés, les intermédiaires utilisés pour leur préparation, des compositions pharmaceutiques les contenant et leur utilisation en médecine sont décrits. Les composés de la présente invention sont de puissants inhibiteurs de la voie de transmission de signal du facteur de croissance transformant ("TGF")-P. Ils sont utiles dans le traitement de divers états pathologiques en rapport avec le TGF, comprenant, par exemple, le cancer et des maladies fibrotiques.
Patent MA-27500-A1 (MA)
Title: Prevention et traitement de la maladie d'alzheimer
Inventor: CANTON THIERRY
IPC: A61K31/55
Filed: 2005-06-10
Abstract: L'invention a pour objet l'application des inhibiteurs de recapture intestinale de l'acide biliaire pour la prévention et le traitement de la maladie d'Alzheimer, le cas échéant en association avec un inhibiteur de HMG-CoA réductase, un inhibiteur de la capture de cholestérol, un inhibiteur de la synthèse de cholestérol ou un inhibiteur des APP secrétases.
Patent MA-38177-A1 (MA)
Title: Charger une ressource web redirigée sur le navigateur web d'un dispositif client dans un système de communications
Inventor: HERSHBERG JOSHUA
IPC: H04L29/08
Filed: 2013-12-12
Abstract: Dans un mode de réalisation selon l'invention, un dispositif client transmet une requête pour une ressource web initiale à un serveur mandataire. Le serveur mandataire demande la ressource web initiale au nom du dispositif client en réponse à la requête du dispositif client. Le serveur mandataire exécute alors une procédure de redirection de ressource web (laquelle consiste en une ou plusieurs redirections) qui est indépendante de l'interaction avec le dispositif client et résulte en l'obtention par le serveur mandataire du contenu de la ressource web. Le serveur mandataire fournit le contenu de la ressource web à une application cliente mandataire sur le dispositif client ainsi que les instructions permettant de simuler, sur le dispositif client, la procédure de redirection de ressource web entre l'application cliente mandataire et un navigateur web mobile sur le dispositif client. L'application cliente mandataire sur le dispositif client simule alors la procédure de redirection de ressource web qui s'est produite au niveau du serveur mandataire conformément aux instructions.
Patent MA-46019-A1 (MA)
Title: Compositions et méthodes pour moduler l'expression de hbv et de ttr
Inventor: PARAKASH THAZHA
IPC: C12N15/113
Filed: 2014-05-01
Abstract: L'invention concerne des composés oligomères à groupes conjugués. Dans certains modes de réalisation de l'invention, ces composés oligomères sont conjugués à la n-acétylgalactosamine
Patent MA-61742-A1 (MA)
Title: Composition pharmaceutique aqueuse d'anticorps anti pd-1 prolgolimab et son utilisation
Inventor: LOMKOVA EKATERINA ALEKSANDROVNA
IPC: A61K39/395
Filed: 2020-08-21
Abstract: L'invention concerne des compositions pharmaceutiques aqueuses pour un anticorps anti pd-1 prolgolimab, ainsi que l'utilisation de ces compositions pharmaceutiques en tant que médicament pour le traitement d'affections induites par le pd-1.
Patent UY-31022-A1 (UY)
Title: Uso de fungicidas para el tratamiento de micosis en peces
Inventor: NEUMANN ULRIKE WACHENDORFF
IPC: A01N43/36
Filed: 2008-04-14
Abstract: Procedimiento para proteger peces e invertebrados y todos sus estadios de desarrollo contra micosis, causadas por hongos de los géneros Saprolegnia, Aphanomyces, Achlyaflagellata y otras especies significativas en acuicultura por medio de la utilizacion de los fungicidas seleccionados, antes mencionados. Este uso lleva a una inhibicion o muerte de hongos patogenos.
Patent ZW-13379-A1 (ZW)
Title: Z-2-acylamino-3-monosubstituted propenoates
Inventor: ROGERS EDWARD FRANKLIN
IPC: C07C235/76
Filed: 1979-07-16
Abstract: Novel-Z-2-Acylamino-3-monosubstituted propenic acids and their esters and salts of the formula <CHEM> wherein R1 is, by preference, hydrogen, lower alkyl or a pharmaceutically acceptable cation, R2 is, by preference, methyl substituted cyclopropyl, (cycloalkyl)alkyl, straight alkyl with more than 4 C-atoms or ramified alkyl and R3 is, by preference, optionally substituted alkyl, are prepared by reacting compounds of the formula     R3-CH2-@-COOR1  with compounds of the formula  R2CONH2  or by acylation of esters of the formula <CHEM>  with an acid chloride     R2@CI  and treating the obtained acylated esters to the formula <CHEM> with t-butylhypochlorite and sodium methoxide, followed by treatment of the resultant intermediate with anhydrous hydrochloric acid. The novel compounds selectively inhibit the metabolism of dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products, by preference with the thienamycin class of compounds.
Patent ES-171766-A1 (ES)
Title: UN PROCEDIMIENTO DE FABRICAR UN SACO SECCIONAL DE AIRE PARA VULCANIZACIoN
Filed: 1945-12-06
Abstract: Procedimiento de construir un saco seccional de vulcanización que tiene un núcleo hueco cerrado por los extremos d euna material impermeable destinado a ponerse a presión interna caracterizado por las siguientes operaciones: conducir una pluralidad de alambres desde bobinas sucesivamente al través de medios de guía llamas un peine y un laminador de caucho con lo cual dichos alambres se empotran parcialmente en una hoja de caucho sin vulcanizar aplicar una copa de caucho sobre dichos alambres parcialmente empotrados formando así una hoja de caucho reforzado por alambres; cortar una tira de dicha hoja reforzada de tamaño adecuado para cubrir un núcleo de caucho hueco cerrado por los extremos con medios de inflación en por lo menos uno de sus extremos cubrir dicho núcleo en la citada hoja y moldear y vulcanizar el conjunto.
Patent ES-180201-A1 (ES)
Title: Procedimiento para la obtencion de cuerpos albuminoideos
Filed: 1947-10-20
Abstract: Procedimiento para la obtención de cuerpos albominóideos especialmente para su utilización como materias sustitutivas del huevo capaces de ser batidas a partir de partes de plantas conteniendo albúmina caracterizado porque se extraen gérmenes de cereales especialmente gérmenes de trigo debajo de la temperatura de coagulación de la albúmina con auxilio de tales medios extractores que ni disuelven ni desnaturalizan la albúmina hasta que están prácticamente libres de aceite.
Patent ES-183480-A1 (ES)
Title: Un modulador de luz
Filed: 1948-04-27
Abstract: Modulador de luz para proyectar imágenes de televisión, en el cual el haz luminoso atraviesa un blanco de transparencia variable modulado por control electrónico. En este modulador, se utiliza como fuente de electrones que vienen a herir el blanco un dispositivo acumulador formado por un mosaico de elementos emisores que actúan simultaneamente sobre toda la superficie de la imagen y se regulan periódicamente por reajuste de los valores de emisión individuales. Este dispositivo permite extender la acción de los electrones mientras dura una imagen y hace actuar el bombardeo electrónico sobre todos los elementos ocupados del blanco a la vez, con el fin de amplificar considerablemente la modulación de la transparencia de dicho blanco.
Patent ES-197433-A1 (ES)
Title: Perfeccionamientos introducidos en los conmutadores de circuitos eléctricos
Filed: 1951-04-14
Abstract: Perfeccionamientos introducidas en los conmutadores de circuitos eléctricos caracterizados por el hecho de que la conmutación del circuito estrella triángulo de un motor eléctrico se verifica después de quitarse la corriente en el estátor del motor del lado opuesto al centro de estrella y abrirse los contactos de la conexión en estrella.
Patent ES-199909-A1 (ES)
Title: PROCEDIMIENTO Y MECANISMO CORRESPONDIENTE, PARA LA FABRICACIoN DE BOLSAS DE LADOS PLEGADOS CON FONDO FORMADO AL LLENARLAS
Filed: 1951-10-08
Abstract: Procedimiento y mecanismo correspondiente, par ala fabricación de bolsas de lados plegados con fondo formado al llenarlas, caracterizado porque en el canto de pliegue del fondo van provistos unos refuerzos de pegamento preferentemente triangulares, los cuales unen las caras plegadas de los lados con las caras exteriores de la bolsa, empujando hacia fuera los pliegues que forman la pared lateral, con lo cual y bajo la acción de la presión de la carga, los extremos triangulares de dichos pliegues laterales se apoyan en el centro plegado del fondo directamente sobre los refuerzo de pegamento del fondo que se forma.
Patent ES-251962-A1 (ES)
Title: Improvements in or relating to the casting of metals
IPC: B22D7/10
Filed: 1959-09-09
Abstract: Shaped articles, such, as sleeves or tiles, for use in the casting of metals are made from a mixture of an exothermic material and wood pulp, paper pulp or cellulosic fibre. In an example, 90 parts by weight of wood pulp are mixed with 10 parts of a specified exothermic material and a binder and formed into tiles suitable for use in the casting of aluminium and low melting point alloys. In a further example, 10 parts by weight of paper pulp are mixed with 90 parts of the same exothermic material and a binder and formed into sleeves for use in the casting of stainless steel at 1600 DEG C.