baber/WOPTO huggingface dataset:
Patent WO-2019191494-A1 (WO)
Title: Personalized cancer vaccines
Inventor: LARSON CHRISTOPHER
IPC: A61K35/761
Filed: 2019-03-28
Abstract: The invention provides for a recombinant adenoviral vector comprising a recombinant oncolytic adenovirus which has: (1) a modified transcription regulatory sequence wherein the adenoviral vector is transcriptionally active in cancer cells and/or hyperproliferative cells and transcriptionally attenuated in normal cells, and (2) a transgene encoding one or more cancer antigens that are specific to a subject. The invention further provides a method of producing said recombinant adenoviral vector. The recombinant oncolytic adenoviral vector described above is used in methods of stimulating a heightened immune response against a cancer antigen in a subject or a method of treating cancer in a subject.
Patent WO-2019204077-A1 (WO)
Title: Sole structure with plates and intervening fluid-filled bladder and method of manufacturing
Inventor: CONRAD BRYAN P
IPC: A43B13/20
Filed: 2019-04-09
Abstract: A sole structure (12) for an article of footwear (10) includes a first plate (40), a fluid-filled bladder (44) supported on the first plate (40), and a second plate (42) supported on the fluid-filled bladder (44) with the fluid-filled bladder (44) disposed between the first plate (40) and the second plate (42). The first plate (40) ascends rearward of the fluid-filled bladder (44) and the second plate (42) descends rearward of the fluid-filled bladder (44) with a posterior portion (54) of the first plate (40) above a posterior portion of the second plate (42) rearward of the fluid-filled bladder (44). A method of manufacturing footwear sole structures (12) includes assembling sole structures (12) for plural ranges of footwear sizes, each of the sole structures (12) including a fluid-filled bladder (44) with a predetermined inflation pressure that is different for at least two of the plural ranges.
Patent WO-2019199974-A1 (WO)
Title: Microrna regulated expression vectors, methods of making, and uses thereof
Inventor: GRUENERT LUKAS DC
IPC: C12N15/63
Filed: 2019-04-10
Abstract: Provided herein are vectors, compositions and methods for treating and diagnosing breast cancer. In exemplary embodiments, the present disclosure provides a vector for the expression of a therapeutic protein, wherein the vector comprises a microRNA binding domain (MBD) that facilitates the expression of the therapeutic protein in breast cancer cells and inhibits the expression of the therapeutic protein in non-breast cancer cells. The present disclosure also provides compositions comprising the vectors and methods of using the vectors for treating and/or diagnosing breast cancer.
Patent WO-2019217673-A1 (WO)
Title: Systems and methods for removing contamination in electroplating systems
Inventor: ROH KWAN WOOK
IPC: C25D5/18
Filed: 2019-05-09
Abstract: Electroplating systems according to the present technology may include a two-bath electroplating chamber including a separator configured to provide fluid separation between a first bath configured to maintain a catholyte during operation and a second bath configured to maintain an anolyte during operation. The system may include a catholyte tank fluidly coupled with the first bath of the two-bath electroplating chamber. The system may also include a contaminant retrieval system configured to remove contaminant ions from the catholyte.
Patent WO-2019217815-A1 (WO)
Title: Endoscopic full thickness resection device
Inventor: KO MICHAEL Y
IPC: A61B17/32
Filed: 2019-05-10
Abstract: The present disclosure relates generally to devices and methods for full thickness tissue resection of an organ (e.g., intestine). In some embodiments, a device includes a conduit, and a plurality of arms rotatably coupled to the conduit. Each of the plurality of arms is movable between a collapsed position and an expanded position, wherein the plurality of arms extends radially outward from the conduit in the expanded position. The device may further include an electrocautery wire coupled to each of the plurality of arms, the electrocautery wire positioned directly adjacent an exterior tissue wall when the plurality of arms is in the expanded position. The device may be advanced back in towards a lumen of the organ until a targeted section of tissue is cut by the electrocautery wire and removed.
Patent WO-2019222086-A1 (WO)
Title: Poincare display to assess autonomic engagement responsive to vagus nerve stimulation
Inventor: LIBBUS IMAD
IPC: A61N1/362
Filed: 2019-05-13
Abstract: A system includes a vagus nerve stimulation (VNS) device configured to deliver a vagus nerve stimulation signal having an ON-period status and an OFF-period status, and a processor and a non-transitory computer readable memory. The memory stores instructions that, when executed by the processor, cause the system to synchronously record a first ECG profile of during the ON-period status and a second ECG profile during the OFF-period status, determine heart rate dynamics from the first and second ECG profiles, the heart rate dynamics including a plurality of R-R intervals in each ECG profile, generate display data configured to be displayed on a display, and transmit the display data to the display. The display data includes the R-R intervals for each of the first and second ECG profiles. The display data further includes a Poincaré plot.
Patent WO-2019226422-A1 (WO)
Title: Small peptides for inhibiting gabp
Inventor: BELL ROBERT JOSEPH ALLEN
IPC: A61P35/00
Filed: 2019-05-15
Abstract: The invention provides compositions and methods for treating cancer by down-regulating telomerase. In particular, the invention provides peptides that inhibit GABP multimerization and its binding to mutant  TERT  promoter sequences.
Patent WO-2019226570-A1 (WO)
Title: Processes for producing bio-based aromatic compounds and derivatives
Inventor: SOOKRAJ SADESH H
IPC: C08G63/82
Filed: 2019-05-20
Abstract: The processes include steps for catalytieally rearranging a bio-based beta-lactone to produce a bio-based unsaturated organic acid; contacting the bio-based unsaturated organic acid with a bio-based conjugated diene to produce a bio-based cyclohexene intermediate; and transforming the bio-based cyclohexene intermediate into a bio-based aromatic acid. Copolymers of the bio-based aromatic acid and a diol are also afforded.
Patent WO-2019241251-A1 (WO)
Title: Ceramic processing and design for the direct manufacture of customized labial and lingual orthodontic clear aligner attachments
Inventor: GRIFFIN ALFRED
IPC: B33Y50/02
Filed: 2019-06-11
Abstract: A method of manufacturing pre-formed, customized, ceramic, labial/lingual orthodontic clear aligner attachments (CCAA) by additive manufacturing (AM) may comprise measuring dentition data of a profile of teeth of a patient, based on the dentition data, creating a three dimensional computer-assisted design (3D CAD) model of the patient's teeth using reverse engineering, and saving the 3D CAD model, designing a 3D CAD structure model for one or more CCAA on various parts of each tooth, importing data related to the 3D CAD CCAA structure model into an AM machine, directly producing the CCAA in the ceramic slurry-based AM machine by layer manufacturing, enabling the provider to deliver patient-specific CCAA's by an indirect bonding method to the patient's teeth to improve the efficacy and retention of the clear aligners.
Patent WO-2019246358-A1 (WO)
Inventor: RETSCH JR
IPC: C08G63/52
Filed: 2019-06-20
Abstract: There is described an acrylic polyester resin, obtainable by grafting an acrylic polymer with a polyester material. The polyester material is obtainable by polymerizing (i) a polyacid component, with (ii) a polyol component, including a diol according to formula (I), as shown in claim 1; wherein R?1#191 and R?2#191 each independently represent a hydrogen radical, a lower alkyl radical or an aryl radical having 6 to 12 carbon atoms, and wherein at least one of R?1#191 or R?2#191 is a lower alkyl radical or an aryl radical having 6 to 12 carbon atoms. R?3#191 and R?4#191 each independently represent a lower alkyl radical or an aryl radical having 6 to 12 carbon atoms. At least one of the polyacid component and/or the polyol component comprises a functional monomer operable to impart functionality on to the polyester resin, such that an acrylic polymer may be grafted with the polyester material via the use of said functionality. Also provided is an aqueous coating composition comprising the acrylic polyester resin and a metal packaging containing coated with the composition.
Patent WO-2020010208-A1 (WO)
Title: Preparing superpositions of computational basis states on a quantum computer
Inventor: JIANG ZHANG
IPC: G06N10/00
Filed: 2019-07-03
Abstract: Methods, systems and apparatus for preparing arbitrary superposition quantum states of a quantum register on a quantum computer, the quantum state comprising a superposition of L computational basis states. In one aspect, a register of log L qubits is prepared in a weighted sum of register basis states, where each register basis state indexes a corresponding quantum state computational basis state, and the amplitude of each register basis state in the weighted sum of register basis states is equal to the amplitude of the corresponding computational basis state in the superposition of L computational basis states. A unitary transformation that maps the register basis states to the corresponding L computational basis states is then implemented, including, for each index 1 to L, controlling, by the register of log L qubits, transformation of the quantum system register state for the index to the corresponding computational basis state for the index.
Patent WO-2020033244-A1 (WO)
Title: Building evacuation method and building evacuation system
Inventor: JIA ZHEN
IPC: G06K9/00
Filed: 2019-08-02
Abstract: The present disclosure discloses a building evacuation system and a building evacuation method. The evacuation method comprises: capturing image data of a region by a plurality of sensors to track a moving state of people in the region; detecting, in the moving state of the people being tracked, an object specified by at least one set abnormal mode, and matching the object with the abnormal mode; and generating an indication representing an abnormality of evacuation behavior based on the abnormal mode after being matched. The present disclosure can provide efficient evacuation.
Patent WO-2020033270-A1 (WO)
Title: Apparatus and method of sharing a sensor in a multiple system on chip environment
Inventor: CHU JEFFREY HAO
IPC: G07C5/00
Filed: 2019-08-02
Abstract: Examples disclosed herein provide mechanisms for controlling a sensor in a multiple System on Chip (SoC) environment that allows one of the multiple System on Chips to be selected as a host System on Chip. The host System on Chip may lock the sensor to apply setting updates only from the host System on Chip that has locked the sensor. This lock may be broadcast to all sensors over an embedded data channel sent to all System on Chips receiving the sensor data. In addition, a safety monitor may be included to detect if the host System on Chip is functioning properly so that another System on Chip may be selected as a new host System on Chip.
Patent WO-2020056066-A1 (WO)
Title: Interleukin-2 polypeptide conjugates and their uses
Inventor: CHEN SIGENG
IPC: A61K45/00
Filed: 2019-09-11
Abstract: The present invention provides methods for targeting interleukin-2 receptor-expressing cells, and, in particular, inhibiting the growth of such cells by using an interleukin-2 (IL-2) variant conjugated to a biologically active molecule that will affect cells expressing the interleukin-2 receptor.
Patent WO-2021050075-A1 (WO)
Title: Fiber optic connector with cable boot release having a two-piece clip assembly
Inventor: HO MAN MING
IPC: G02B6/38
Filed: 2019-09-12
Abstract: Connector assemblies are described herein. For example, a connector assembly including: a housing configured to accept a first ferrule and a second ferrule. The connector assembly may also have a push/pull clip that is configure to depress a protrusion that rotates down a connector device to remove the connector assembly from an adapter. The push/pull clip is integrated with a cable boot assembly that allows a user to apply a distal force to remove or insert the connector assembly into the adapter housing. The push/pull clip is configured for use to release a MPO and LC connector type from an adapter
Patent WO-2021054939-A1 (WO)
Title: Double acting boost arrangement
Inventor: REID MICHAEL ADAM
IPC: E21B34/14
Filed: 2019-09-17
Abstract: A valve assembly, is presented that has a seating member is slidably coupled to a valve body adjacent a valve body bore and has a metal seat located on a seating end thereof that is engagable against a ball valve member. The seating member has a vent port located there through to allow fluid to flow into a fluid chamber within the ball housing. A first piston is slidably located between the seating member and the ball housing and located over the vent port, and a second piston is slidably located between the seating member and the ball housing and is located downhole from the first piston. Sealing members are located between the first and second pistons and engaged against the seating member.
Patent WO-2020061143-A1 (WO)
Inventor: KAPUR NAVIN
IPC: A61M60/36
Filed: 2019-09-18
Abstract: We provide herein a method of preventing or limiting the effects of heart failure in a human patient that has sustained myocardial infarction by reducing maladaptive cardiac remodeling in the patient. The method comprises percutaneously inserting a transvalvular blood pump, comprising a rotor and a cannula, into the patient's vasculature and positioning the cannula across the aortic valve of the patient's heart, with a distal end of the cannula located in the left ventricle of the heart and a proximal end of the pump located in the aorta. The method then comprises, prior to reperfusing the heart, operating the positioned pump to unload the left ventricle at a pumping rate of at least 2.5 L/min of blood flow for a support period between at least 30 minutes and less than 60 minutes. Then, after the support period, the method comprises applying coronary reperfusion therapy to the heart.
Patent WO-2020077011-A1 (WO)
Inventor: SONI CHIRAG
IPC: G10L25/63
Filed: 2019-10-09
Abstract: System and methods for generating a product recommendation based on reactions such as bio-feedback of a subject during a virtual try-on session are described herein. A recommendation engine captures bio-feedback and determines whether the subject has a positive or negative attitude towards a certain feature of a product that is being virtually "tried on" with the subject. The recommendation engine can then provide a product recommendation based on the actual sentiment of the subject towards a product feature.
Patent WO-2020077255-A1 (WO)
Inventor: BLANCO-PILLADO MARIA
IPC: C07J1/00
Filed: 2019-10-11
Abstract: Provided herein is a compound of Formula (I) or a pharmaceutically acceptable salt thereof, wherein n, R19, R5, R3a, R6a, R6b, R1, R2a, R2b, R4a, R4b, R7a, R7b, R11a, R11b, R12a, R12b, R17b, R15a, R15b, R16a and R16b are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds, e.g., in the treatment of CNS-related disorders.
Patent WO-2020117372-A1 (WO)
Title: Scan cube characteristics
Inventor: HANDSHAW DARRAN MICHAEL
IPC: G06K7/14
Filed: 2019-10-14
Abstract: A barcode reader is provided. The barcode reader comprises an imaging assembly having a field of view (FOV) extending along one or more horizontal planes and a housing of the imaging assembly, the housing being a cuboid shape having six sides. The FOV of the imaging assembly passes through an opening in a first side of the housing with a width that is 1.5 inches or greater. The first side of the housing has a width that is greater than or equal to 2.5 inches and less than or equal to 3.5 inches, and has a height that is greater than or equal to 2.0 inches and less than or equal to 3.5 inches. The housing is substantially stable when at least a portion of a second side of the housing, substantially parallel to at least one of the one or more horizontal planes, is placed on a flat surface.
Patent WO-2020092278-A1 (WO)
Inventor: DAN BO
IPC: H05K9/00
Filed: 2019-10-29
Abstract: A thermal management device with electromagnetic (EM) shielding includes a fin pack with a plurality of channels. The fin pack has an upper and lower surface. The fin pack has a pack length, pack height, and pack width. The fin pack has fins are oriented connecting the upper surface to the lower surface. The plurality of channels extends from a first end toward a second end. A first channel of the plurality of channels is adjacent the upper surface, and a second channel of the plurality of channels is adjacent the lower surface.
Patent WO-2020167353-A1 (WO)
Title: Dispositif de vaporisation ayant des modes de fonctionnement pouvant être commandés à distance
Inventor: GREENBAUM SEAN
IPC: A24F40/10
Filed: 2019-11-14
Abstract: La présente invention concerne des dispositifs de vaporisation ayant des parties destinées à permettre une transmission de signal à travers celles-ci. Un dispositif de vaporisation comprend un corps ayant une première extrémité, une seconde extrémité et formant une cavité interne. Au moins une partie de la cavité interne forme un réceptacle de cartouche. Le dispositif de vaporisation comprend une batterie disposée à l'intérieur de la cavité interne et un processeur couplé fonctionnellement à la batterie et disposé à l'intérieur du corps. Le processeur est conçu pour répondre à un signal pour commuter le dispositif de vaporisation entre un premier mode de fonctionnement et un second mode de fonctionnement. Le dispositif de vaporisation comprend également une partie du corps conçue pour permettre la transmission du signal à travers la partie du corps depuis un emplacement externe au corps, ce qui permet au processeur de commuter le dispositif de vaporisation entre les premier et second modes de fonctionnement en réponse à la réception du signal.
Patent WO-2020112917-A1 (WO)
Inventor: COOPER JOSHUA
IPC: H03M7/40
Filed: 2019-11-26
Abstract: A system and method for high-speed transfer of small data sets, that provides near-instantaneous bit- level lossless compression, that is ideal for communications environments that cannot tolerate even small amounts of data corruption, have very low latency tolerance, where data has a low entropy rate, and where every bit costs the user bandwidth, power, or time so that deflation is worthwhile. Where some loss of data can be tolerated, the system and method can be configured for use as lossy compression.
Patent WO-2020117753-A1 (WO)
Inventor: MORGAN AMIR H
IPC: D04B1/18
Filed: 2019-12-03
Abstract: Des aspects de la présente invention concernent une chaussette (100) ayant une première bande tricotée (110) s'étendant à partir d'un aspect latéral d'une ouverture de la chaussette, et une seconde bande tricotée (112) s'étendant à partir d'un aspect médial de l'ouverture de la chaussette. Chacune de la première bande tricotée et de la seconde bande tricotée est tricotée avec une pluralité de rangées s'étendant d'un premier bord longitudinal à un second bord longitudinal de la bande tricotée respective, au moins une partie des rangées étant formée à l'aide d'un fil élastomère.
Patent WO-2021118523-A1 (WO)
Inventor: OSBORNE PAUL
IPC: B41J2/175
Filed: 2019-12-09
Abstract: In one example in accordance with the present disclosure, a print fluid refill system is described. The print fluid refill system includes a reservoir to hold a volume of print fluid to be supplied to a printhead. The print fluid refill system also includes a pump to 1 ) draw print fluid from the reservoir via a reservoir line and 2) transport print fluid to a reserve tank via a reserve line. The print fluid refill system also includes the reserve tank to, during refill of the reservoir, supply print fluid to a printhead via a printhead line. The reserve tank supplies print fluid to the printhead when fluid is passed to the reservoir via a return line.
Patent WO-2020142448-A1 (WO)
Inventor: CHEN YI-WEN
IPC: H04N19/137
Filed: 2019-12-30
Abstract: The present disclosure relates to a method for deriving constructed affine merge candidates. The method includes acquiring, from a decoder, a regular merge flag for a coding unit (CU) which is coded as merge mode and merge related modes, when the regular merge flag is one, indicating that regular merge mode or merge mode with motion vector differences (MMVD) is used by the CU, constructing a motion vector merge list for the CU and using regular merge index to indicate which candidate is used, and when the regular merge flag is zero, indicating regular merge mode is not used by the CU, and further receiving mode flags to indicate associated merge related modes are used when a mode flag's constraints are met.
Patent WO-2020142515-A1 (WO)
Title: Multi-transmitter sensor system
Inventor: FAHEY BRIAN
IPC: A61F2/82
Filed: 2019-12-31
Abstract: Implantable relay devices that are configured to communicate with implantable sensing devices, the sensing devices spaced away from the implantable relay devices.
Patent WO-2020197615-A1 (WO)
Title: Devices, systems and methods for wireless communication system employing overlapping frequency bands
Inventor: STRAUCH PAUL
IPC: H04W72/04
Filed: 2020-01-20
Abstract: According to embodiments, methods, devices and systems can include monitoring all of a first channel for a first monitoring period. After the first monitoring period, monitoring at least one narrow band for at least a first narrow band signal. In response to detecting the first narrow band signal, establishing a network connection over the narrow band, wherein the at least one narrow band has a frequency range less than one half that of the first channel.
Patent WO-2020160004-A1 (WO)
Title: Processus de désulfuration en continu basé sur des sorbants régénérables à base d'oxyde métallique
Inventor: GUPTA RAGHUBIR PRASAD
IPC: B01D53/18
Filed: 2020-01-28
Abstract: L'invention concerne un processus de désulfuration en continu et un système de traitement pour l'élimination d'espèces de soufre réduites à des concentrations de flux de gaz dans une plage d'environ 5 à environ 5000 ppmv, à l'aide de lits fixes contenant des sorbants régénérables, et pour la régénération de tels sorbants régénérables. La désulfuration élimine les espèces de soufre réduites de sulfure d'hydrogène, de sulfure de carbonyle, de disulfure de carbone, et/ou de thiols et de disulfures avec quatre atomes de carbone ou moins, à des concentrations de ppbv. Dans des modes de réalisation particuliers de l'invention, des sorbants régénérables à base d'oxyde métallique sont intégrés conjointement avec un processus fonctionnel et efficace pour commander la réaction et le processus de régénération tout en maintenant une capacité de soufre dynamique stable. Un processus et un système à base de membrane sont décrits pour produire une régénération et un gaz de purge pour la désulfuration.
Patent WO-2020172199-A1 (WO)
Inventor: YATES JOSHUA
IPC: C12N15/11
Filed: 2020-02-18
Abstract: An improved method for the rapid and efficient production of guide strand libraries is disclosed. Also included are kits comprising reagents suitable for practicing the method. Embodiments may include a polynucleotide comprising a sequence encoding for a constant region comprising a protein binding segment of an RNA component of a CRISPR complex. The sequence may comprise a non-palindromic recognition sequence for a first restriction enzyme having methyltransferase activity and configured to cleave at least 17 nucleotides outside of the non-palindromic recognition sequence, wherein at least one base of the non-palindromic recognition sequence is configured to be methylated by the first restriction enzyme, thereby blocking endonuclease activity of the first restriction enzyme.