Patent SG-11201809471U-A (SG)
Title: Polymorphic forms of 3-[2-butyl-1-(2-diethylamino-ehtyl)-1h-benzoimidazol-5-yl]-n-hydroxy-acrylamide and uses thereof
Inventor: DUNCAN DAVID
IPC: A61K31/4353
Filed: 2017-05-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111 01110101011111 010111110 I 0111110101011111H 01111111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\"1 WO 2017/192451 Al 09 November 2017 (09.11.2017) WIP0 I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/282 (2006.01) A61K 31/4353 (2006.01) kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, PCT/US2017/030414 CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (22) International Filing Date: HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, 01 May 2017 (01.05.2017) KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (25) Filing Language: English PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (26) Publication Language: English SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (30) Priority Data: TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 62/330,673 02 May 2016 (02.05.2016) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant: MEI PHARMA, INC. [US/US]; 11975 El GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, Camino Real, Suite 101, San Diego, California 92130 (US). UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (72) Inventor: DUNCAN, David; 9525 Oviedo Street, San TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Diego, California 92129 (US). EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (74) Agent: GRUMBLING, Matthew V. et al.; WILSON TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, SONSINI GOODRICH & ROSATI, 650 Page Mill Road, KM, ML, MR, NE, SN, TD, TG). Palo Alto, California 94304 (US). = (54) Title: POLYMORPHIC FORMS OF 3-[2-BUTYL-1-(2-DIETHYLAMINO-EHTYL)-1H-BENZOIMIDAZOL-5-YL]-N-HY- DROXY-ACRYLAMIDE AND USES THEREOF = = FIG. 1 = 100 £ = 901 = I = = $ A' 1 = 601 c / = i 1 = _ t 1 :c, gt = _ 46 _ = $01 _ 20 11 11 ,...,•,..ikk..“) Al , . 1 1' t0 i 6 ,:-.4 10 12 14 16 18 20 22 24 26 28 30 32 34 36 38 40 ei 28 r] tT 1-1 IN ,-1 (57) : Crystalline polymorph forms of 342-butyl-1-(2-diethylamino-ethyl)-1H-benzoimidazol-5-y1]-N-hydroxy-acrylamide 0 are described. Pharmaceutical compositions and the uses of such compounds, compound forms, and compositions for the treatment of N diseases and conditions are also presented. [Continued on next page] WO 2017/192451 Al MIDEDIMOMMIDIRMEMOMOHEIDEIVIDEDIIMOVOIMIE Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the earlier application (Rule 4.17(iii)) priority of the Published: — with international search report (Art. 21(3))