baber/WOPTO huggingface dataset:
Patent HR-P20100357-T1 (HR)
Title: Beta-crystalline form of perindopril arginine salt, process for its preparation, and pharmaceutical compositions containing it
Inventor: COQUEREL GURARD
IPC: A61K31/404
Filed: 2010-06-28
Abstract: Beta crystalline form of perindopril arginine salt (I), characterized by the X-ray diffraction diagram on powder, measured by a diffractometer (copper anticathode) and exhibited a Bragg angle 2 theta (expressed in percentage in relation to the most intense line), an interreticular distance (d), an intensity and a relative intensity, as given in table of the specification, is new. Beta crystalline form of perindopril arginine salt of formula (I), characterized by the X-ray diffraction diagram on powder, measured by a diffractometer (copper anticathode) and exhibited a Bragg angle 2 theta (expressed in percentage in relation to the most intense line), an interreticular distance (d), an intensity and a relative intensity, as given in table of the specification, is new. Independent claims are included for: (1) a composition comprising (I) in combination with inert and nontoxic vehicles; and (2) the preparation of (I). ACTIVITY : Cardiovascular-Gen; Hypotensive; Cardiant. MECHANISM OF ACTION : Angiotensin I converting enzyme inhibitor. No biological data given.
Patent HR-P20110148-T1 (HR)
Inventor: WILL HEINER
IPC: A61P25/28
Filed: 2011-02-28
Abstract: Upotreba metotreksata u proizvodnji medikamenta kojeg treba primijeniti supkutano, kod liječenja upalnih autoimunih bolesti, naznačena time što metotreksat se nalazi u farmaceutski prihvatljivom otapalu, u koncentraciji od otprilike 50 mg/ml. Patent sadrži još 27 patentnih zahtjeva.
Patent HR-P20120705-T1 (HR)
Inventor: WERNER ZAMBACH
IPC: C07D211/94
Filed: 2012-09-05
Abstract: Spojevi sa formulom I naznačeni time daX , Y i Z, nezavisno jedan od drugoga su C1-4alkil, C3-6cikloalkil, C1-4haloalkil, C1-4alkoksi, halogen, fenil ili fenil supstituiran sa C1-4alkilom ili halogenom, C1-4haloalkil, halogen ili cijano, m i n, nezavisno jedan od drugoga su 0, 1, 2 ili 3, gdje m+n je 0, 1, 2 ili 3, G je vodik, metal, amonijak, sulfonij ili latentna skupina koja je odabrana iz skupina C1-C8alkil, C2-C8haloalkil, fenilC1-C8alkil (pri čemu fenil proizvoljno mo·e biti supstituiran sa C1-C3alkilom, C1-C3haloalkilom, C1-C3alkoksi, C1-C3haloalkoksi, C1-C3alkiltio, C1-C3alkilsulfinilom, C1-C3alkilsulfonilom, halogenom, cijano ili sa nitro), heteroarilC1-C8alkil (pri čemu heteroaril proizvoljno mo·e biti supstituiran sa C1-C3alkilom, C1-C3haloalkilom,
Patent HR-P20130852-T1 (HR)
Title: Methods for diagnosis and treatment of diseases having an autoimmune and/or inflammatory component
Inventor: AUKERMAN SHARON LEA
IPC: A61P37/00
Filed: 2013-09-11
Abstract: Methods for identifying subjects having an inflammatory disease and/or autoimmune disease that will benefit from anti-CD40 therapeutic agents that modulate CD40L-mediated CD40 signaling are provided. The methods comprise the use of biomarkers of cellular apoptosis, cell proliferation and survival, and CD40 signaling pathways to monitor  ex vivo  response to one or more anti-CD40 therapeutic agents of interest that modulate CD40 signaling on CD40-expressing cells. The  ex vivo  prognostic assays can be used alone or in conjunction with other prognostic assays to identify candidate subjects who will benefit from treatment with anti-CD40 therapeutic agents. Methods of the invention also comprise the use of these biomarkers to monitor  in vivo  efficacy of treatment with an anti-CD40 therapeutic agent.
Patent SI-1499194-T1 (SI)
Title: Fungicidal composition comprising a potentiating compound, a plant activating microbicide and a fungicidal compound
Inventor: LABOURDETTE GILBERT
IPC: A01N57/00
Filed: 2003-04-29
Abstract: Fungicidal composition comprises:  (1) phosphorous acid or its alkali(ne earth) metal salts or derivatives;  (2) a selected plant defense elicitor; and (3) a fungicide that inhibits electron transport in the mitochondrial ubiquinol:ferricytochrome-c oxidoreductase respiratory chain of phytopathogenic fungi or inhibits ergosterol biosynthesis or inhibits spore germination through several metabolic routes.  Fungicidal composition comprises:  (1) phosphorous acid or its alkali(ne earth) metal salts or derivatives; (2) a plant defense elicitor selected from proteins, oligosaccharides, polysaccharides, lipids, glycolipids, glycoproteins, peptides, plant and fungal extracts, fungi, acibenzolar S-methyl or its analogs, 2,6-dichloroisonicotinic acid, beta-aminobutyric acid, yeast extract, salicylic acid, salicylate esters and seaweed extracts; and (3) a fungicide that inhibits electron transport in the mitochondrial ubiquinol:ferricytochrome-c oxidoreductase respiratory chain of phytopathogenic fungi or inhibits ergosterol biosynthesis or inhibits spore germination through several metabolic routes.
Patent SI-1631511-T1 (SI)
Title: A refuse bin including a compacting mechanism
Inventor: LAPORTE YVAN NEOVE DESIGN
IPC: B65F1/00
Filed: 2004-05-13
Abstract: A refuse bin comprises a refuse container ( 10 ) having a top opening ( 12 ) and a lid ( 14 ) hinged relative to the container to cover the opening. A compacting mechanism is fitted to the lid and comprises a compacting plate ( 22 ) mounted under the lid and an actuating rod ( 24 ) coupled to the compacting plate through an aperture ( 26 ) in the lid. The coupling is such that the rod ( 24 ) may be maneuvered from a storage position wherein the rod lies across the top surface of the lid and the plate is drawn up under the lid to an operative position wherein the rod stands upright over the aperture in the lid and may be pushed downwardly through the aperture to push the plate down into the container. The compacting mechanism further comprises a ratchet mechanism ( 50, 52, 54 ) for releasably locking the actuating rod ( 24 ) against movement upwardly through the aperture in the lid such that refuse in the container can be compacted by force applied to an edge ( 48 ) of the lid opposite the hinge.
Patent SI-1835937-T1 (SI)
Title: Compositions and methods for treating viral infection
Inventor: WAGTMANN PETER ANDREAS NICOLAI REUMERT
IPC: A61K39/00
Filed: 2006-01-06
Abstract: Described are methods of treating viral disease using compounds that block inhibitory NK cell receptors, thereby reducing their inhibition of NK cell cytotoxicity in killing infected target cells. In one embodiment, the compound is an antibody binding, for example, one or more of the human KIR2DL1, KIR2DL2, and KIR2DL3 receptors. In another embodiment, the method further comprises administering a therapeutic antibody or fusion protein which binds an antigen expressed on cells infected with the virus.
Patent SI-2526933-T1 (SI)
Title: Inhibitors of Bruton's tyrosine kinase
Inventor: HONIGBERG LEE
IPC: C07D487/00
Filed: 2006-12-28
Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
Patent SI-1992570-T1 (SI)
Title: Mouldable small packaging medium
Inventor: KRALLMANN RAINER
IPC: B65D47/04
Filed: 2007-05-16
Abstract: Deformable small packaging unit comprises an outer sleeve (12) lying on a pouring spout (16) in a meandering manner. Preferred Features: The outer sleeve has an inner annular flange which interacts with a recess of a support element. The outer sleeve has a peripheral bar lying on the inner annular flange and interacting with the groove of the support element. The support element has outer threads for holding a screw cap.
Patent SI-2743433-T1 (SI)
Title: Locking device for a sliding door
Inventor: MULLER PETER
IPC: E05B83/00
Filed: 2013-12-09
Abstract: The device has a door lock moved between a pre-locking position and a main detent position, and a closing aid completely closed in a closing operation based on manually adjusted position of a sliding door (10). The closing aid comprises a main stage for independently adjusting the main detent position based on the pre-locking position in the closing operation. The closing aid includes a primary stage (18) arranged upstream to the main stage for independently adjusting the pre-locking position based on the main detent position in the closing operation.
Patent TR-200700243-T1 (TR)
Inventor: GUELBAS FERKAN
IPC: B67B7/16
Filed: 2005-07-11
Abstract: This invention relates to a cooling device (1) which comprises a bottle opener (6) on its door (2).
Patent DE-3382690-T2 (DE)
Inventor: IWANICKI ANDRZEJ TOMASZ
IPC: F16L19/06
Filed: 1983-08-11
Granted: 1994-01-20
Abstract: 1 - Coupling including a connection disposed for receiving with a sliding fit a coupling member (70) which, on forced axial displacement into or in over the connection, is intended to act on clamping and sealing means axially compressible by the coupling member (20) or connection in which it is inserted, for translating the compression forces generated by the axial compression into radial compression forces against the connection or against a pipe or coupling piece inserted in the coupling, characterized in that the coupling member has axially projecting, resilient gripping means (71) with radially inwardly projecting hooks, for engaging against a collar (72) disposed on the periphera surface of the connection, the collar having a radially projecting edge facing away from the gripping means, the coupling member comprising two parts (66, 67) in threaded engagement, and with the aid of locking flanges formed in said parts retain between them the gripping means as well as the clamping and sealing means, said means, on screwing up the parts of the coupling member, being pressed into engagement against the collar edge, as well as against the peripheral surface of the connection or the pipe or the coupling piece.
Patent DE-3751564-T2 (DE)
Inventor: DEGRYSE ERIC
IPC: C12P21/00
Filed: 1987-08-05
Granted: 1996-03-28
Abstract: Process for stabilising a plasmid vector present in a bacterium, characterised in that the bacterium comprises a dap<-> chromosome mutation and in that the plasmid vector carries a dap<+> gene.
Patent DE-3787431-T2 (DE)
Inventor: GLACKEMEYER RICHARD E
IPC: G06F11/26
Filed: 1987-08-18
Granted: 1994-01-13
Abstract: The method and apparatus for isolating faults in circuitry of a digital computer includes the use of a fault isolation generation program which provides a data base containing a list of possible faulty components for each cycle of the computer's clock for execution by a service processor of the actual computer during testing. The fault isolation generation program is generated by using a simulator loaded with a mathematical model of the actual computer in connection with the execution of the diagnostic program executed on the actual computer during testing. The fault isolation program generates a list of circuit elements capable of generating fault indications, excluding circuit elements not capable of generating such fault indications.
Patent DE-3853394-T2 (DE)
Inventor: CHILDRESS THOMAS EDGEWORTH
IPC: C07F7/04
Filed: 1988-09-27
Granted: 1995-07-27
Abstract: An extractive distillation process for recovering trimethoxysilane from a trimethoxysilane-methanol mixture is provided using as the extractive solvent tetramethoxysilane.
Patent DE-3875731-T2 (DE)
Inventor: SPARKS SAM L
IPC: A61F2/00
Filed: 1988-09-05
Granted: 1993-03-18
Abstract: Methods and apparatus for maintaining urinary continence in normally incontinent individuals. The present invention involves the non-surgical implantation of a bolus of ferromagnetic material into the bladder. The bolus of ferromagnetic material may comprise a biocompatible membrane, containing a ferromagnetic material. The bolus (10) will normally rest at the juncture between the bladder (14) and the urethra (12) and will prevent the flow of urine from the bladder into the urethra. Essentially, the bolus serves as a seal between the urethra and the bladder. When it is desired to void the bladder, the ferromagnetic bolus is moved out of the intersection between the bladder and the urethra by positioning a magnet along the external surface of the person's body and manipulating the magnet until the desired movement of the bolus is accomplished. Movement of the magnet is sufficient to displace the bolus such that flow may be initiated from the bladder into the urethra.
Patent DE-3886172-T2 (DE)
Inventor: JACQUIER ROBERT
IPC: C07K1/06
Filed: 1988-04-29
Granted: 1994-06-09
Abstract: Process for the preparation of optically pure peptide synthons in which an amino acid or a silylated peptide activated by a phosphorus-containing derivative is condensed with an amino acid or an N-silylated peptide in which the acidic functional group is protected.
Patent TR-199802483-T2 (TR)
Inventor: PARIKH BHAVNISH VINOD
IPC: A61K31/55
Filed: 1997-05-27
Abstract: Bu bulus, 11[ 4-[ 2-(-hidroksietoksi) etil ]-1-piperazinil ] dibenzo[ b, f ][ 1,4] tiazepin veya bunun farmasötik açidan kabul edilebilir bir tuzunu ihtiva eden sürekli tahliye edici formülasyonlar, bu sürekli tahliye edici formülasyonlari kullanalarak psikotik  durumlari ve hiperaktiviteyi tedavi etme yöntemleri ve sürekli tahliye formülasyonlarini hazirlamaya mahsus bir yöntemle ilgilidir.
Patent TR-199902399-T2 (TR)
Inventor: HENDRIKS HENRICUS ENGELBERTUS
IPC: C08L95/00
Filed: 1998-04-20
Abstract: Mevcut bulus, bir emülsiflestirilmemis çok yumusak birlestirici bilesen ve çakilli kum karisimina, bir çok sert birlestirici bilesenin eklenmesini kapsayan bir açik düzenlenmis asfalt bilesiminin hazirlanmasi için bir islem saglar.
Patent TR-199902577-T2 (TR)
Inventor: MEYER KEITH C
IPC: A61K45/00
Filed: 1998-04-16
Abstract: Bir uyku periyodu öncesinde arka yutak bölgesine uygulanan sentetik veya dogal akciger sürfaktani, apne veya hipopne ile sonuçlanan uyku rahatsizligi episodlarini azaltir. Mevcut bulus, kullanimi ve saklanmasi kolay bir aplikatör kap içinde akciger sürfaktani saglar. Oksijen desatürasyonu durumlari azaltilir, böylece apneye bagli patolojilerin riski düsürülür.
Patent TR-199903129-T2 (TR)
Inventor: O'CONNOR LAWRENCE J
IPC: B65H75/36
Filed: 1998-06-17
Abstract: Serit halindeki bir malzeme paketi (10), her biri ileri ve geri yönde katlanmis vaziyette duran belirli uzunlukta seridi (11) içeren, paralel yan yana kümeler (20, 21, 22, 23) silsilesinden olusur. Kümenin (20, 21, 22, 23) katlanmis olan her parçasi, seridin (11) eni yönündeki bir çizgi üzerinde ve esit parçalarin yan kenarlari ayni hizaya gelecek sekilde bir sonraki parçaya bagil olarak katlanir. Serit (11) tüm kümeler (20, 21, 22, 23) dahilinde kesintisiz vaziyette bulunur ve bir  kümenin sonu ile bir sonraki kümenin baslangici arasinda bir ek (46) ile birbirine baglanir. Kümelerin (20, 21, 22, 23) yüksekliginin azaltilmasi için paket (10) sikistirilir ve bosaltilmis yalitimli bir torba (40) içerisinde sikistirilmis durumda muhafaza edilir. Tercih edilen paket (10) düzenlenmesinde seridin (11) olusturuldugu yönde basari ile kullanilabilmesi için, kümeler (20, 21, 22, 23) bir destek üzerinde durur vaziyette ve denge amaciyla kümeler bir destek yüzeyine (81) yaslanacak (DEVAMI VAR....)
Patent DE-60001934-T2 (DE)
Inventor: ENRIETTI PIERO
IPC: B29C45/28
Filed: 2000-05-18
Granted: 2004-02-19
Abstract: The actuating unit comprises a piston element (21) slidable in a cylinder element (20) and connectable to a closure rod (16) slidable in an injection duct (14) between an extended position in which it blocks an injection hole (15) and an injection position in which it is retracted into the injection duct. The piston element (21) has an engaged seat (46, 47) which can house a head end portion (16a) of the rod (16). The engagement seat is shaped so as to allow the piston element (21) to be translated transversely relative to the axial direction of movement of the rod (16) in order to release the piston element (21) from the rod.
Patent DE-60003599-T2 (DE)
Inventor: FOESSEL PASCAL
IPC: A01N43/50
Filed: 2000-04-05
Granted: 2003-12-24
Abstract: The present invention provides a method for the synergistic control of undesirable plants such as Poa, Polygonum and Setaria which comprises applying to the plants or their locus a synergistically effective amount of a combination of a dinitroaniline compound and an imidazolinone compound. Further provided are synergistic herbicidal compositions comprising dinitroaniline and imidazolinone compounds.
Patent DE-60009825-T2 (DE)
Inventor: LEMCOFF NORBERTO
IPC: A23L3/3427
Filed: 2000-10-17
Granted: 2005-04-21
Abstract: Apparatus and method for controlling the composition of the atmosphere within a refrigerated container (13) during the storage and/or transportation of perishable and/or respiring produce in which carbon dioxide and ethylene (and other evolved hydrocarbons) are removed from the atmosphere by adsorption in vessel (1), the adsorptive materials (109,107,105,103) being regenerated with ambient air. <IMAGE>   <IMAGE>
Patent DE-60016905-T2 (DE)
Inventor: DI BENEDETTO CALOGERO
IPC: F04B17/04
Filed: 2000-03-13
Granted: 2005-12-29
Abstract: A composite piston (30) for a vibration pump comprises a core (32), activating a piston, and a piston (34) made of plastic and obtained by means of molding on an insert formed by the core (32). The composite piston (30) thus obtained achieves objects of high precision at a low cost which cannot be achieved with traditional simple pistons made entirely of ferromagnetic metal.
Patent DE-60017888-T2 (DE)
Inventor: BAY E
IPC: C07C235/58
Filed: 2000-04-05
Granted: 2006-01-19
Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. Preferred delivery agents include, but are not limited to, N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC), N-(10-[2-hydroxybenzoyl]amino)decanoic acid (SNAD), and sodium N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC). The invention also provides methods of preparing the disodium salt, ethanol solvate, and hydrate and compositions containing the disodium salt, ethanol solvate, and/or hydrate.
Patent DE-60021630-T2 (DE)
Inventor: HIBI SHIGEKI
IPC: A61K31/519
Filed: 2000-12-13
Granted: 2006-06-08
Abstract: Fused heterocyclic compounds (I) are new. Fused heterocyclic compounds of formula (I) and their salts and hydrates are new. [Image] A, B, D, E, G : N, O, S, (CR 1R 2) m, CO, CS, NR 3, SO or SO 2; R 1, R 2H, Alk, 2-6C alkenyl, 2-6C alkynyl, CycOAlk, AlkOAlk, AlkCyc or 1-6C alkyl-aryl, or CR 1R 23-8 membered ring or is replaced by CR 2=CR 2 or N=CR 2; m : 0-4; Alk : 1-6C alkyl; Cyc : 3-8C cycloalkyl; R 3H, COR 4, S(O) nR 5, Alk 2, optionally substituted aryl or optionally benzene fused Cyc (optionally substituted by 1-4C alkyl); Alk 21-10C alkyl, 2-10C alkenyl or 2-10C alkynyl (all optionally substituted by Q); R 4, R 5Alk or Ar; n : 0-2; J : N, CJ 1, NJ 1 or CJ 1J 1; J 1H, amino, CN, Alk, 1-6C haloalkyl, SO 2NHAlk, aryl or optionally substituted, optionally unsaturated heterocyclyl; K, L : C or N; M : H, halo, CN, Alk 3, NR 11R 12, OR 13, S(O) qR 14, or optionally substituted 2-10C alkenyl, 2-10C alkynyl, aryl or heteroaryl; Alk 3Alk, OAlk or SAlk (all optionally substituted by 1 or more Q); Q : halo, OH, NO 2, CN, COOH, COOAlk, S(O) rR 15, NR 18R 19, Alk, OAlk, Cyc (optionally substituted by 1-4C alkyl), 1-4C alkoxy-1-6C alkyl, 3-8 membered saturated heterocyclyl (optionally substituted by 1-4C alkyl), or optionally substituted aryl or heteroaryl; R 11, R 12H, Alk (optionally substituted by Q), 1-4C alkylacyl or Ar; Ar : optionally substituted aryl-1-4C alkyl, heteroaryl-1-4C alkyl, aryl or heteroaryl; R 13H, Q, 1-4C alkylacyl or Ar; R 14Alk or Ar; q : 0-2; R 15, R 16H Alk (optionally substituted by optionally substituted aryl), 1-4C alkylacyl or Ar; R 18, R 19H, Alk or 1-4C alkylacyl; provided that: (i) KEGJL form a 5 or 6 membered optionally unsaturated ring; and (ii) when K and L = N or K = N, L = C, A, B = CH2 then J is not amino, CN, optionally substituted aminosulfonyl or C(1H-tetrazol-5-yl). ACTIVITY : Antidepressant; tranquilizer; antiinflammatory; hypotensive; gastrointestinal; antiulcer; antiemetic; nootropic; neuroprotective; anabolic; anorectic; antidiabetic; CNS; anticonvulsant; antialcoholic; analgesic; cerebroprotective; auditory; endocrine; vasotropic; cytostatic; anti-HIV; hemostatic; osteopathic; antithyroid; antiasthmatic. MECHANISM OF ACTION : Corticoliberin antagonist. In assays using AtT-20 cells, 8-(1-ethylpropyl)-3-mesityl-2,5-dimethyl-7,8-dihydro-6H-pyrazolo(1,5-a)pyrrolo(3,2-e)pyrimidine (Ia) HCl exhibited an IC 50 value for CRF 1 receptor binding of 100 nM.
Patent DE-60022031-T2 (DE)
Inventor: ZHU ZHIHONG
IPC: F16J9/20
Filed: 2000-06-06
Granted: 2006-06-08
Abstract: A piston ring assembly consists of an upper ring and a lower ring. Said upper ring and lower ring have a common axis, an outer toward common annular surface, and inner toward common annular surface and mutual contact surfaces. Said two contact surfaces keep to contact with each other in a contact section which has radially an outer end and an inner end. Said tow contact surfaces stretch radially oppositely from said outer end to form a first wedge space, the vertex of which being in the outer end and, with said outer toward common annular surface. The vertex angle is about 1030 &squ& . The distance between said outer end and said outer toward common annular surface is greater than the distance between said inner end and said inner toward common annular surface. The present invention also includes a piston wherein said piston ring assembly is being used. <IMAGE>
Patent DE-60023253-T2 (DE)
Inventor: KANOMI RYUZO
IPC: A61C7/00
Filed: 2000-12-21
Granted: 2006-07-13
Abstract: PURPOSE: To provide a dentition orthodontic support having good handleability to solve a problem of a difficult treating operation due to a dentition orthodontic treatment to be conducted in a narrow space of a mouth. CONSTITUTION: The dentition orthodontic support comprises an implanting member 21 embedded in a jaw, and a coupling member 22 having an arm 14 with a connecting part 15. The member 21 has a necked part 28 at its head 17. The member 22 has an engaging part 26 including an open part 16a at one side, and the part 26 can be engaged with the part 28. In this case, the part 26 is slid along the part 28 of the member 21, and fixed by caulking its tip part 26b. Thus, its mounting method is simple.
Patent DE-60024500-T2 (DE)
Inventor: CHRISTOU PAUL
IPC: C12N15/63
Filed: 2000-07-18
Granted: 2006-07-20
Abstract: This invention relates to methods for producing, at a high frequency, transgenic plants that contain little if any vector sequences, have simple integration patterns, contain few copies of the transgene at each locus, express the transgene at all stages of development and do not exhibit transgene silencing. The method comprises introducing minimal transgene expression cassettes, which are substantially or totally devoid of vector sequences, by direct DNA transfer, preferably by particle or microprojectile bombardment This invention also relates to transformed plant cells, the transgenic plants regenerated therefrom, and subparts of the transgenic plants produced by the methods of this invention. The invention also includes all progeny and subsequent progeny (i.e., all subsequent generations) derived from primary transformants through selfing or crossing.