Patent SG-11201408078P-A (SG)
Title: Methods and compositions for improving gut microbiota population
Inventor: ZHAO LIPING
IPC: A23L33/00
Filed: 2013-06-04
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 December 2013 (12.12.2013) WIPOIPCT (10) International Publication Number WO 2013/182038 A1 (51) International Patent Classification: A61K36/8964 (2006.01) A61K36/756 (2006.01) A61K36/744 (2006.01) A61K36/718 (2006.01) A61K36/708 (2006.01) A61K36/539 (2006.01) A61K36/515 (2006.01) A61K36/489 (2006.01) A61K36/42 (2006.01) A61K36/29 (2006.01) A61K36/288 (2006.01) A61K36/185 (2006.01) A61P1/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: PCT/CN2013/076709 4 June 2013 (04.06.2013) English (26) Publication Language: (30) Priority Data: 201210185004.2 6 June 2012 (06.06.2012) English CN (71) Applicants: SHANGHAI JIAO TONG UNIVERSITY [CN/CN]; No.800 Dongchuan Rd, Minhang District, Shanghai 200240 (CN). PERFECT (CHINA) CO., LTD [CN/CN]; Dongming north Rd, Shiqi District, Zhongshan City, Guangdong 528420 (CN). (72) Inventors: ZHAO, Liping; No.800 Dongchuan Rd, Min­ hang District, Shanghai 200240 (CN). ZHANG, Xu; No.800 Dongchuan Rd, Minhang District, Shanghai 200240 (CN). ZHANG, Menghui; No.800 Dongchuan Rd, Minhang District, Shanghai 200240 (CN). ZHAO, Yufeng; No.800 Dongchuan Rd, Minhang District, Shang­ hai 200240 (CN). PANG, Xiaoyan; No.800 Dongchuan Rd, Minhang District, Shanghai 200240 (CN). ZHANG, Xiaojun; No.800 Dongchuan Rd, Minhang District, Shanghai 200240 (CN). WANG, Linghua; No.800 Dongchuan Rd, Minhang District, Shanghai 200240 (CN). NING, Guang; No.800 Dongchuan Rd, Minhang District, Shanghai 200240 (CN). LI, Xiaoying; No.800 Dongchuan Rd, Minhang District, Shanghai 200240 (CN). ZHANG, Yifei; No.800 Dongchuan Rd, Minhang District, Shanghai 200240 (CN). (74) Agent: SHANGHAI HANGSOME INTELLECTUAL PROPERTY LTD.; Room 307, No.56, Lane 3828,Yindu Rd, MinHang District, Shanghai 201108 (CN). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) [Continued on next page] (54) Title: METHODS AND COMPOSITIONS FOR IMPROVING GUT MICROBIOTA POPULATION ; oo m o CJ 00 -0-2 0-0 0.2 - , . . <12.6%) KFD: NCD- weeft 0 9 week 0 S HFD week 0 NCD-weefc S ^ !\JCD+BBR-we«fc 8 ^ HFD- weeks NCD-week1S # NCD+BBR-w«efc 18 # HFD-vve«k1S FIGURE 1 f 7 i it--... . t - i week 0 week 8 week 18 HFO*SBR-weefcO HFD+SBR- week S HFD+8BR- we«k 1S i-H o CJ (57) Abstract: A method and a compostion for improving gut microbiota structure, selectively increase a first gut microbiota popu - lation while simultaneously decrease second a gut microbiota population in a subject. The first gut microbiota population includes a short-chain fatty acid (SCFA)-producing bacterium and the second gut microbiota population includes an endotoxin- producing bac­ terium. WO 2013/182038 A11 lllll llllllll II llllll III lllll lllll III III III lllll lllll lllll llll llll lllll lllll lllllll llll llll — with sequence listing part of description (Rule 5.2(a))