Patent SG-11201809902Q-A (SG)
Title: Functional prediction of cellular functions by means of microrna expression profiling in mesenchymal stem cells
Inventor: MALLINSON DAVID
IPC: C12Q1/68
Filed: 2017-05-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111101011111111111 01110111110111111111111111101111111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/194561 Al 16 November 2017 (16.11.2017) WIPO I PCT (51) International Patent Classification: (84) Designated States (unless otherwise indicated, for every C12Q 1/68 (2006.01) kind of regional protection available): ARIPO (BW, GH, (21) International Application Number: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, PCT/EP2017/061096 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (22) International Filing Date: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 09 May 2017 (09.05.2017) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (25) Filing Language: English KM, ML, MR, NE, SN, TD, TG). (26) Publication Language: English Published: (30) Priority Data: — 1608081.4 09 May 2016 (09.05.2016) GB with international search report (Art. 21(3)) 1608086.3 09 May 2016 (09.05.2016) GB 1608497.2 13 May 2016 (13.05.2016) GB (71) Applicant: SISTEMIC SCOTLAND LTD [GB/GB]; West of Scotland Science Park, Block 3, Units 3, 4 & 5, Kelvin Campus, Glasgow G20 OSP (GB). (72) Inventors: MALLINSON, David; c/o Sistemic Scotland _ Ltd, West of Scotland Science Park, Block 3, Units 3, 4 & 5, Kelvin Campus, Glasgow G20 OSP (GB). DUNBAR, Don- ald; c/o Sistemic Scotland Ltd, West of Scotland Science = Park, Block 3, Units 3, 4 & 5, Kelvin Campus, Glasgow G20 OSP (GB). GOURLAY, Elaine; c/o Sistemic Scotland = Ltd, West of Scotland Science Park, Block 3, Units 3, 4 & _ 5, Kelvin Campus, Glasgow G20 OSP (GB). OLIJNYK, = Dania; c/o Sistemic Scotland Ltd, West of Scotland Science = Park, Block 3, Units 3, 4 & 5, Kelvin Campus, Glasgow G20 _ OSP (GB). REID, James; c/o Sistemic Scotland Ltd, West of Scotland Science Park, Block 3, Units 3, 4 & 5, Kelvin Campus, Glasgow G20 OSP (GB). Agent: ELLIS, Michael; Ellis IP Ltd, 53/4 George Street, Edinburgh EH2 2HT (GB). = (74) = Designated States (unless otherwise indicated, for every (81) = kind of national protection available): AE, AG, AL, AM, = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = = HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, = — KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, = MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = 1-1 ,_ 1 (54) Title: FUNCTIONAL PREDICTION OF CELLULAR FUNCTIONS BY MEANS OF MICRORNA EXPRESSION PROFILING IN MESENCHYMAL STEM CELLS in 1 1' (57) : Non-coding RNA, such as miRNA, expression data derived from a cell population is used to infer the propensity of that CN cell population for a cellular functional effect for a pre-determined purpose, which effect is temporally, procedurally or interventionally 1-1 ---. separated from the cell population from which the expression data is derived. Thereby, the cellular functional effect of a cell population Ir---- can be predicted in order to improve decisions and selections to be made relating to the use of cells, e.g. from cells deriving from different 1-1 c;;;;) donors or batches, for use in bioprocess application or cell therapeutics, in order to enhance productivity, efficiency and/or efficacy. ei O