baber/WOPTO huggingface dataset:
Patent CA-2517589-A1 (CA)
Title: Method for preparing small particles
Inventor: WONG JOSEPH CHUNG TAK
IPC: A61K31/495
Filed: 2004-02-25
Abstract: The present invention is concerned with the formation of small particles or organic compounds by precipitating the organic compounds in an aqueous medium to form a pre-suspension followed by adding energy to stabilize a coating of the particle or to alter the lattice structure of the particle. The process includes the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution; (ii) mixing the solution with the second solvent to define a presuspension of particles; and (iii) adding energy to the presuspension to form a suspension of particles having an average effective particle size of less than about 100 µm. The process is preferably used to prepare a suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrate route such as parenteral, oral, pulmonary, nasal, buccal, topical ophthalmic, rectal, vaginal, transdermal or the like.
Patent CA-2518882-A1 (CA)
Inventor: ANZAR MUHAMMAD
IPC: C12N5/071
Filed: 2004-03-29
Abstract: Apparatus and methods for analyzing particles, including apparatus and methods for a sperm sorting process including: collecting sperm from an animal (30);  selecting staining conditions (47A); staining the sperm with DNA selective fluorescent dye (48); sorting the sperm cells according to sex chromosome content (55); and cryopreserving a population of sorted sperm (61) until used for artificial insemination. One embodiment includes apparatus (1001) and methods for using a plurality of flow cytometry units (9) sharing an integrated platform to sort sperm cells. In one embodiment, flow cytometric sorting includes use of the following apparatus and methods: an orienting nozzle having a baffle (101); an epi-illumination optics system (109); slit scanning of localized DNA regions within cell nuclei (225); digital signal processing, including synchronous sampling of analog output signals (701), pulse waveform (497) feature extraction of an approximation of a first order derivative of a pulse waveform (497) at a point of the pulse, any of various sort strategies; and an automated sort calibration system (4201). In one embodiment, digital signal processing includes sampling analog output signals (701) at times relative to emission of pulses from an illumination laser.  Other embodiments are substantially different from the foregoing, including embodiments directed to individual steps or systems that can be used for any of various applications involving particle analysis.
Patent CA-2518889-A1 (CA)
Inventor: GLASER MATTHIAS EBERHARD
IPC: C07C45/71
Filed: 2004-03-12
Abstract: The invention relates to conjugates of formula (V) or (VI): wherein X is -CO-NH-, -NH-, -O-, -NHCONH-, or -NHCSNH-; their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.
Patent CA-2521136-A1 (CA)
Inventor: CHEN KER-SANG
IPC: G01N33/50
Filed: 2004-03-31
Abstract: Novel methods of determining efficacy of a treatment of inflammatory diseases of the bowel in mammals are provided. The methods are of use in screening and determining the efficacy of treatments of inflammatory diseases of the bowel, and for determining the efficacy response of individual sufferers of inflammatory diseases of the bowel to a given regime. Kits for carrying out the method are also provided.
Patent CA-2521324-A1 (CA)
Inventor: WRIGHT DAVID WALTER
IPC: A01N1/02
Filed: 2004-04-02
Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the organ cassette with one or more openings configured to allow tubing to pass through the openings and be connected to the organ or tissue within the cassette, and including a pressure control device to allow pressure inside the portable housing to be varied. The apparatus and methods further include the cassette with heat transfer surfaces arranged to transfer heat between a cooling source in said transporter and the heat transfer surfaces. The apparatus and methods further include a tube frame removably connected to the cassette and configured to hold a plurality of tubes in a position to be connected to tubes in the portable housing.
Patent CA-2521558-A1 (CA)
Title: Novel composition for hormonal balance and uses thereof
Inventor: CHOKSHI DILIP
IPC: A61K9/16
Filed: 2004-05-11
Abstract: The present invention provides a composition and methods of using composition consisting essentially of a soy component, chasteberry, clover, and black cohosh, in a suitable carrier, optionally with each of the soy component, chasteberry, clover, and black cohosh is enrobed in a glycoprotein matrix.
Patent CA-2521590-A1 (CA)
Inventor: FUKUYAMA KOHKI
IPC: A41G3/00
Filed: 2004-04-09
Abstract: A device and a method for hair implantation, wherein, with a base sheet (11) formed of an elastic material stretched, the intermediate part of a hair segment is arrested by the reciprocating motion of a needle (41a) and a shape retainable bent part (30a) is formed at the intermediate part. The bent part is left on one surface of the base sheet and fixed to the one surface by a first adhesive layer (111), and a pair of long hair extension parts (30b) extending from both ends of the bent part are extracted to the other surface side of the base sheet through holes (11a) formed by breaking through the base sheet when the needle is raised. After the hair segments of a specified quantity are fixedly implanted in the base sheet in such a manner, the stretched state of the base sheet is eliminated or relieved to contract the base sheet by its own elasticity and reduce the diameters of the holes. Then, a second adhesive layer (112) covering the entire part of the one surface of the base sheet is formed to prepare a surface for mounting the base sheet on the skin of a person.
Patent CA-2522421-A1 (CA)
Title: Methods of therapy and diagnosis using targeting of cells that express killer cell immunoglobulin-like receptor-like protein
Inventor: EMTAGE PETER C R
IPC: C12Q1/68
Filed: 2004-04-13
Abstract: Certain cells, including types of cancer cells such as KIRHy1, are capable of expressing KIRHy1 mRNA. Targeting using KIRHy1 polypeptides, nucleic acids encoding for KIRHy1 polypeptides and anti-KIRHy1 antibodies provides a method of killing or inhibiting that growth of cancer cells that express the KIRHy1 protein. Methods of therapy and diagnosis of disorders associated with KIRHy1 protein-expressing cells, such as acute myelogenous leukemia (AML), are described.
Patent CA-2524232-A1 (CA)
Title: Lc resonant circuit with amplification device
Inventor: MAZOKI GARY
IPC: G06K19/077
Filed: 2004-04-30
Abstract: A security tag includes a combination of a resonant frequency circuit (10) with an adjacent amplification shield (12) for enhancing output signal amplitude. The amplification shield is located adjacent to the resonant frequency circuit and is preferably in the same or substantially the same plane as the resonant frequency circuit or is in a close, generally parallel plane. In an exemplary embodiment, the resonant frequency circuit includes an inductor electrically coupled to a capacitor. The resonant frequency circuit has a center frequency and is arranged to resonate in response to exposure to electromagnetic energy at or near the center frequency, providing an output signal having an amplitude. The amplification shield is arranged to direct a portion of the electromagnetic energy to the resonant frequency circuit to amplify the amplitude of the output signal from the resonant frequency circuit.
Patent CA-2528726-A1 (CA)
Inventor: WALKER F JOSEPH
IPC: C08L101/12
Filed: 2005-12-02
Abstract: A cured magnetizable admixture of elastomeric thermoplastic, dispersed magnetizable particulate, and optional dispersed hydrophobic material (such as ethylene acrylic monomer rubber or ethylene-vinyl acetate copolymer) provides elastic elongation of not less than about 50 percent at break and water swell of not greater than about 10 percent after curing in magnetizable articles such as target wheels. The magnetizable composition beneficially combines mechanical and durability advantages of traditionally-used thermoset elastomer-based magnetic compounds, under the range of conditions needed for vehicle encoder applications, with the processing and manufacturing advantages of engineered thermoplastics.
Patent CA-2531868-A1 (CA)
Title: Process for the preparation of thalidomide
Inventor: MULLER GEORGE W
IPC: A61K31/403
Filed: 1994-07-01
Abstract: The present invention relates to compounds which are useful for reducing levels of TNF.alpha. in a mammal.      Examples of compounds include those of formula:        See formula 1 wherein, for example, R7 is a cyclic alkyl, a substituted phenyl, etc ...; n is 1 and R12 is an alkoxy, a disubstituted amino, etc ...; those of formula:      See formula 2 wherein, for example, Z is See formula 3 n is 1, 2 or 3;      R1 is a divalent residue of 3,4-pyridine, pyrrolidine, etc ...;      R2 is -CO- or -SO2-; R3 is a substituted phenyl, pyridyl, etc ...; and R4 is alanyl, argynyl, etc ...;               or those of formula:    wherein, for example, an optionally substituted o-phenylene, a divalent residue of pyridine, etc ...; R6 is -CO-, -CH2- or -SO2-; R7 is pyridyl, substituted phenyl etc ...; and R12 is -OH, alkoxy, etc ...;
Patent CA-2532046-A1 (CA)
Title: Acrylate-free binders containing an epoxy resin and an alkyl silicate
Inventor: SHRIVER RANDALL
IPC: B22C3/00
Filed: 2004-07-23
Abstract: This invention relates to foundry binder systems, which cure in the presence of sulfur dioxide and an oxidizing agent, comprising (a) an epoxy resin; (b) an alkyl silicate; (c) an ester of a fatty acid, (d) an effective amount of a oxidizing agent, and (e) no ethylenically unsaturated monomer or polymer. The foundry binder systems are used for making foundry mixes. The foundry mixes are used to make foundry shapes (such as cores and molds) which are used to make metal castings, particularly ferrous castings.
Patent CA-2533795-A1 (CA)
Inventor: FITZGIBBON JAMES J
IPC: G08C19/00
Filed: 2006-01-23
Abstract: A secure communication link (24) is provided between a movable barrier operator (23) and a peripheral alarm system (20). Information conveyed via this link is used by one, the other, or both such elements to further inform or direct their respective actions.
Patent CA-2534868-A1 (CA)
Inventor: ALBERDI ALFONSO ELENA
IPC: A61K31/00
Filed: 2004-08-04
Abstract: The invention relates to the treatment of autoimmune and demyelinating diseases and, in particular, the treatment of multiple sclerosis. The treatment consists of the administration of P2X purinergic receptor antagonists, which leads to a remission of the symptoms associated with said type of diseases. The aforementioned result has been demonstrated using both in vitro cell models and animal models.
Patent CA-2536411-A1 (CA)
Inventor: METCALFE LEONARD
IPC: G01B11/00
Filed: 2006-02-14
Abstract: Apparatus for optically measuring a remote object comprises at least one source for projecting a plurality of discrete zones of electromagnetic radiation (for example laser spots) along a projection plane. Imaging apparatus images a plurality of reflections from the remote object. By spatially offsetting the imaging apparatus from the projection plane, easier discrimination and identification of the reflections is made possible.
Patent CA-2538977-A1 (CA)
Title: Anti-incendiary flexible intermediate bulk container system
Inventor: EBADAT VAHID
IPC: B65D90/46
Filed: 1994-10-21
Abstract: The present invention provides for an antistatic flexible fabric material (10) formed from woven, axially oriented crystalline polypropylene yarn (11,12) having a coating of flexible thermoplastic polymer or blend (22) on one or both sides. The fabric may also contain a layer of cellulose material (24) laminated to the uncoated side. Antistatic properties are imparted to the fabric by including a polyol ester of a C10 to C28 fatty acid in the coating and optionally in the polypropylene yarn (11, 12). The present invention also provides for a quasi-conductive woven fabric section including quasi-conductive fibers which reduce the potential for incendiary discharge. The woven fabric section (10) may further include an antistatic coating. The coating may be applied to an entire surface of the woven fabric section or it may coat about one-half of the section.
Patent CA-2540367-A1 (CA)
Title: An enzyme for catalyzing biosynthesis of piperitol and/or sesamin
Inventor: ONO EIICHIRO
IPC: H04N5/217
Filed: 2004-09-29
Abstract: The present invention provides an enzyme that catalyzes the reaction producing piperitol from pinoresinol, and a reaction producing sesamin from piperitol. The invention also provides a gene that encodes such enzyme. Further, the invention provides a vector and transformant including a gene encoding the enzyme, and a producing method of the protein using the transformant.
Patent CA-2543696-A1 (CA)
Title: Combinations for hcv treatment
Inventor: TUNG ROGER D
IPC: A61K31/7056
Filed: 2004-10-27
Abstract: The present invention relates to co-administering a Hepatitis C virus NS3/4A  protease inhibitor and a cytochrome P450 monooxygenase inhibitor. The combination acts by interfering with the life cycle of the hepatitis C virus and is therefore useful as an antiviral therapy. As such, the combination may be used for treating or preventing Hepatitis C infections in patients. The invention also relates to compositions comprising the combination of inhibitors. The invention also relates to kits and pharmaceutical packs comprising a Hepatitis C virus NS3/4A protease inhibitor and a cytochrome P450 monooxygenase inhibitor. The invention also relates to processes for preparing these compositions, combinations, kits, and packs.
Patent CA-2543742-A1 (CA)
Title: Grounding plate assembly for a drum in an image forming apparatus
Inventor: TODD DANIEL R
IPC: G03G15/00
Filed: 2004-11-01
Abstract: A photosensitive drum assembly for an image forming apparatus. A drum defines first and second open ends. A flange is partially disposed in the first open end. A grounding plate assembly includes a drum contact member and a shaft contact member. The drum contact member is configured to remove an electrically resistive coating from an interior of the drum. The shaft contact member is configured to contact a grounding shaft. The shaft contact member is disposed entirely within an interior of the flange.
Patent CA-2546470-A1 (CA)
Inventor: PITZEN JAMES F
IPC: F16B2/18
Filed: 2004-10-27
Abstract: A lever device (102, 302) includes an elongated body (104, 304) and a double-sided stretch releasing adhesive (108, 330, 332) attached to the body, whereby the body can be firmly adhesively bonded to a surface (110, 326) and cleanly removed from the surface without damaging the surface by stretching the adhesive. The device may include a base, a body member (120) pivotally connected with the base, and stretch releasing adhesive arranged to attach the base and/or body member to a surface or object. The base may be pivotally connected with an end of the body member or to the middle of the body member.
Patent CA-2546505-A1 (CA)
Title: Hybrid cemented carbide composites
Inventor: MIRCHANDANI PRAKASH K
IPC: C22C29/06
Filed: 2004-12-02
Abstract: Embodiments of the present invention include hybrid composite materials comprising a cemented carbide dispersed phase and a cemented carbide continuous phase. The contiguity ratio of the dispersed phase of embodiments may be less than or equal to 0.48. The hybrid composite material may have a hardness of the dispersed phase that is greater than the hardness of the continuous phase. For example, in certain embodiments of the hybrid composite material, the hardness of the dispersed phase is greater than or equal to 88 HRA and less than or equal to 95 HRA and the hardness of the continuous phase is greater than or equal to 78 and less than or equal to 91 HRA. Additional embodiments may include hybrid composite materials comprising a first cemented carbide dispersed phase wherein the volume fraction of the dispersed phase is less than 50 volume percent and a second cemented carbide continuous phase, wherein the contiguity ration of the dispersed phase is less than or equal to 1.5 times the volume fraction of the dispersed phase in the composite material. The present invention also includes a method of making a hybrid cemented carbide composite by blending partially and/or fully sintered granules of the dispersed cemented carbide grade with ~green~ and/or unsintered granules of the continuous cemented carbide grade to provide a blend. The blend may then be consolidated to form a compact. Finally, the compact may be sintered to form a hybrid cemented carbide.
Patent CA-2546576-A1 (CA)
Title: Solid molded polycarbonate member having improved optical and processing characteristics
Inventor: ROEHNER JUERGEN
IPC: B29C48/08
Filed: 2004-11-09
Abstract: The invention relates to solid molded polycarbonate members having improved optical and processing characteristics.
Patent CA-2546733-A1 (CA)
Inventor: ELZEIN ELFATIH
IPC: C07D473/00
Filed: 2004-11-15
Abstract: Disclosed are processes for the synthesis of novel compounds that are AZB  adenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea.
Patent CA-2547990-A1 (CA)
Title: Pharmaceutical compositions and methods for insulin treatment
Inventor: GYURIK ROBERT J
IPC: A61K38/28
Filed: 2004-12-02
Abstract: Compositions and methods for treating a patient with insulin that combines insulin, a permeation enhancer, and a carrier that maintains an acidic pH, are disclosed.
Patent CA-2550746-A1 (CA)
Title: Durable lightweight imaged nonwoven wipe
Inventor: NOLAN BENJAMIN
IPC: D04H/
Filed: 2004-12-15
Abstract: The present invention is directed to a nonwoven fabric, and specifically to a durable lightweight nonwoven fabric wipe, comprising improved strength, as well as an improved MD to CD elongation ratio, which results in a material imminently suitable for application in the cleaning and cleansing of surfaces.  A method of making the nonwoven fabric embodying the present invention includes the steps of providing a precursor web comprising a fibrous matrix.  The method further comprises the steps of providing a precursor web, which is subjected to hydroentangling.
Patent CA-2554468-A1 (CA)
Inventor: GARAPATI PAVAN K
IPC: G06Q40/04
Filed: 2005-01-31
Abstract: A system (10) for matching orders (20) includes a memory that stores bids for a trading product, each bid associated with at least one trader and a market (18), bid quantity and bid price for the trading product. The system also includes a processor that receives (152) an order (20) specifying an offer for the trading product, the order (20) further specifying an offer quantity for the trading product and a target offer price for the trading product. At least one of the bids having a price that is greater than or equal to the target offer price is identified and matched (44) with the offer of the order (20) if the identified bid is associated with a trader, and routes the order (20) to a particular market (18) if the identified bid is associated with the particular market (18).
Patent CA-2561178-A1 (CA)
Title: Adhesion promoting compound
Inventor: DUNCAN ROBERT HUME
IPC: C09D11/03
Filed: 2005-03-17
Abstract: The invention comprises an adhesion promoter for a printing ink and a printing ink comprising the adhesion promoter. The adhesion promoter comprises the product of (a) mixing together a solution of a polymer or synthetic resin with an organophosphorus compound, and then (b) mixing the mixture formed in (a) with a titanium compound selected from a titanium halide, alkoxide, halo-alkoxide or a condensed titanium alkoxide or a mixture of more than one of these titanium compounds.
Patent CA-2561367-A1 (CA)
Inventor: MATSUZAKI HIROFUMI
IPC: G01N33/68
Filed: 2006-02-27
Abstract: A protein crystal detecting method for detecting a protein crystal in protein solution held in a crystallizing container, wherein layer images are obtained by imaging cross sections of a protein solution, a crystal feature image for each layer is created by extracting a feature portion of a protein crystal from the layer images, judgment parameters such as a representative number of pixels representing the number of pixels of the layer image showing the largest feature portions, a representative average number of pixels for each label, and a layer-to-layer rate of nonchange representing the ratio of the number of pixels of the feature portion of one layer to that of its adjacent layer from layer information on the number of pixels of the feature portion and the number of label, these judgment parameters are compared with judgment thresholds, a protein crystal is distinguished from other products by the difference between their thicknesses, and thus the production state of protein crystal is judged. With this, a protein crystal detecting device and a protein crystal detecting method for detecting a protein crystal with high accuracy are provided.
Patent CA-2564164-A1 (CA)
Inventor: RUFFIEUX KURT
IPC: A61K33/42
Filed: 2005-05-06
Abstract: Moldable bone implants for use in a bone defect or wound include a plurality of biocompatible granules and a biocompatible polymer that together form an implant mass. The polymer is softened with a plasticizer to make the implant mass moldable or flowable. The plasticizer can dissipate or be extracted to cause the implant mass to harden. The implant mass can be shaped in-situ or ex-situ. Implants formed in-situ are shaped by the bone defect or wound. The implant becomes hard through contact with body fluids, which extracts the plasticizer from the implant mass. Bone implants formed ex-situ, such as in a mold, are shaped by a mold, for example, and then hardened by placing the implant mass in contact with a hardening agent, such as water, which extracts the plasticizer from the implant mass. The shaped, hardened implant can be placed into a bone defect of corresponding size and shape.
Patent CA-2564964-A1 (CA)
Title: Method of uniaxially expanding a fluoropolymer product
Inventor: HILL JASON
IPC: B29C55/06
Filed: 2004-12-30
Abstract: This invention relates to a method of uniaxially expanding a fluoropolymer product including the steps of expanding a green fluoropolymer product in a first direction to create a first-expanded fluoropolymer product, and expanding the first-expanded fluoropolymer product in the same first directiom. As a result with the subject invention, it has been found that ultra-high expansion and a variety of different porous/fibril structures can be achieved by using subsequent expansion steps in the same direction. Various considerations exist with such methodology, including the selection of rates of expansion of both steps, the amount of expansion of both steps, pre-heating and cutting the product between expansion steps. Although the present invention can be used with various fluoropolymer products, it is particularly well-suited for use with PTFE
Patent CA-2566441-A1 (CA)
Title: Methods of activating chromium catalysts
Inventor: MCDANIEL MAX P
IPC: B01J20/34
Filed: 2005-05-06
Abstract: New methods for activating chromium catalysts for polymerization processes decrease the amount of time required for activation and increase catalyst activity. Rapid heating to a first temperature is followed by a first hold period before heating to a higher second temperature and maintaining the second temperature for a second hold period. In one aspect, the overall activation process takes less than 10 hours.