baber/WOPTO huggingface dataset:
Patent CA-3122518-A1 (CA)
Title: Kink resistant peel away medical sheath
Inventor: LIU CLIFFORD M
IPC: B29C48/23
Filed: 2019-12-09
Abstract: Devices and methods for providing a kink resistant peel away sheath are disclosed. One device includes a sheath for insertion into a vasculature of a patient. The sheath (300) comprises a sheath body (105) having an outer surface, a longitudinal axis and a lumen (108) formed therethrough. The sheath body (105) comprises an inner layer (110) arranged about the longitudinal axis, an outer layer (120) coaxially arranged with the inner layer (110), and a support layer (130) positioned between the inner and outer layers (110,120), wherein the inner, outer and support layers (110, 120, 130) are laminated together to form the sheath body (105). The sheath (300) also comprises at least one shear line (144) positioned beneath the outer surface of the sheath body (105), and configured to facilitate the longitudinal separation of the sheath body (105) along the at least one shear line (144).
Patent CA-3124317-A1 (CA)
Inventor: XU YANPING
IPC: C07D513/04
Filed: 2019-12-19
Abstract: L'invention concerne des composés utiles pour le traitement d'une infection par le VHB chez un sujet en ayant besoin, des compositions pharmaceutiques de ceux-ci, et des procédés d'inhibition, de suppression ou de prévention d'une infection par le VHB chez le sujet.
Patent CA-3127301-A1 (CA)
Inventor: HENNESSY ALAN JOSEPH
IPC: C07D221/20
Filed: 2020-02-10
Abstract: La présente invention concerne des composés de formule (I), dans laquelle R1, R2, R3, R4 et G sont tels que définis dans la description. L'invention concerne en outre des compositions herbicides comprenant un composé de formule (I) et leur utilisation pour lutter contre les mauvaises herbes, en particulier dans des cultures de plantes utiles.
Patent CA-3127778-A1 (CA)
Inventor: KO ALEXANDER
IPC: B05C17/005
Filed: 2019-12-11
Abstract: L'invention concerne un ensemble applicateur de produit (100) comprenant un boîtier ayant une première extrémité et une seconde extrémité ; une force de distribution ; un dispositif de distribution (310) fonctionnellement lié à la force de distribution ; au moins une source d'alimentation (400) ; un commutateur de distribution (120) lié de manière fonctionnelle à la force de distribution ; un opérateur de données (112) connecté électriquement à une source d'alimentation électrique. L'invention concerne également un applicateur d'appât et un procédé d'utilisation de l'applicateur pour appliquer un appât.
Patent CA-3128833-A1 (CA)
Inventor: REISSNER JOACHIM
IPC: B29C64/393
Filed: 2021-08-20
Abstract: A process control method for a 3D-printing process, in particular a stereolithography process and/or a DLP (digital light processing) process, using a 3D printer is provided.  The 3D printer has a building platform, a light source, a receiving device for printing material and a control device by means of which an item can be produced layer-wise or continuously from the printing material. The method is characterised in that a thermal imaging camera, the output signal of which is transmitted to the control device, is attached to the 3D printer, and the method comprising the following steps: =    illuminating a layer or parts of said layer positionally selectively, =    detecting the temperature of the layer during the polymerisation using the thermal imaging camera, =    ending the building process of a layer by ending the illumination, the time of the end of the illumination being established by a predefined temperature T.x or a predefined change in temperature dT/dt being reached.
Patent CA-3129468-A1 (CA)
Title: Wheat variety 6plsk70b
Inventor: LASKAR WILLIAM JOSEPH
IPC: C12N5/04
Filed: 2021-08-31
Abstract: A wheat variety designated 6PLSK70B, the plants and seeds of wheat variety 6PLSK70B, methods for producing a wheat plant produced by crossing the variety 6PLSK7OB with another wheat plant, and hybrid wheat seeds and plants produced by crossing the variety 6PLSK7OB with another wheat line or plant, and the creation of variants by backcrossing, mutagenesis or transformation of variety 6PLSK7OB  are disclosed. Methods for producing other wheat varieties or breeding lines derived from wheat variety 6PLSK7OB and to wheat varieties or breeding lines produced by those methods are also provided.
Patent CA-3130860-A1 (CA)
Inventor: BLOCK TRAVIS
IPC: C12N5/073
Filed: 2020-02-21
Abstract: Disclosed herein are methods of using a cell-derived extracellular matrix derived in-vitro from cells isolated from amniotic fluid (AFC-ECM) for the maturation of immature cardiomyocytes derived from human induced pluripotent stem cells (immature hiPSC-CMs) in culture forming mature cardiomyocytes. Also disclosed herein is a cell construct comprising a monolayer of these mature cardiomyocytes on an AFC-ECM useful for cardiotoxicity and/or proarrhythmic screening assays of drug compounds. Also disclosed herein are methods for determining the cardiotoxicity and/or proarrhythmic effect of a drug compound in vitro using such cell constructs.
Patent CA-3131854-A1 (CA)
Inventor: AAS LARS MARTIN SANDVIK
IPC: A01K61/95
Filed: 2020-02-18
Abstract: The invention relates to a system and method that enables the capture of high contrast images of sea lice contaminated fish. The system comprises a light emitting device, a 2D array detector, and a first polarisation filter,and utilizes polarised narrow bands of light in order to obtain a strong contrast between sea lice and the skin of the fish. A number of narrow bands of light are irradiated onto a fish, and the resulting reflection(s) is/are polarisation filtered before being detected. The detected light is subsequently used in order to generate a high contrast image of the fish.
Patent CA-3135360-A1 (CA)
Title: Pipeline d'exploration de flux de graphiques pour une detection efficace de sous-graphe
Inventor: DALEK DANIEL
IPC: G06F16/904
Filed: 2020-03-30
Abstract: L'invention concerne un système et un procédé de traitement d'exploration de flux de graphiques qui peuvent être utilisés pour analyser les données à partir d'une pluralité de flux de données. Dans un mode de réalisation, le système et le procédé de traitement d'exploration de flux de graphes peuvent être utilisés pour détecter un ou plusieurs nuds malveillants de réseaux de zombies candidats.
Patent CA-3136697-A1 (CA)
Inventor: ROCK KELLY
IPC: B01D61/04
Filed: 2020-04-10
Abstract: A water treatment system includes a primary evaporator and a secondary evaporator that is also a primary condenser. The primary evaporator relies on imparting rotational motion to the fluid to atomize it. The secondary evaporator may be a tube and shell heat exchanger. Embodiments include heat exchangers for using waste heat of various components. In an embodiment, concentrated effluent is recirculated and combined with influent to improve efficiency of the system to achieve zero liquid discharge and aid in continuous cleaning of the system.
Patent CA-3137716-A1 (CA)
Inventor: CHEE MARK S
IPC: A61B5/00
Filed: 2020-04-17
Abstract: L'invention concerne des procédés et des compositions d'analyse spatiale de macromolécules (par exemple, des protéines, des polypeptides ou des peptides). Dans certains modes de réalisation, les procédés selon l'invention permettent d'analyser une macromolécule ou une pluralité de macromolécules, (par exemple, des peptides, des polypeptides et des protéines), par détermination d'informations spatiales et séquençage de la macromolécule. Dans certains modes de réalisation, l'analyse met en oeuvre le codage à barres et l'encodage d'acides nucléiques d'événements de reconnaissance moléculaire, et/ou des marqueurs détectables. L'invention concerne également des compositions, par exemple des kits, contenant des composants permettant la mise en oeuvre des procédés selon l'invention pour l'analyse de la macromolécule.
Patent CA-3139371-A1 (CA)
Title: Gold nanoparticle-aptamer conjugate-based antibody delivery system, and preparation method thereof
Inventor: LEE KANG SEOK
IPC: A61K47/54
Filed: 2019-09-11
Abstract: The present invention relates to a gold nanoparticle-aptamer conjugate-based antibody delivery system, and a preparation method thereof. In the antibody delivery system according to the present invention, a gold nanoparticle is bound to an IgG Fc domain-specific aptamer or FITC-specific aptamer, and the aptamer is specifically bound to an antibody to be delivered, so that the antibody can be effectively delivered to not only the nucleus and cytoplasm of a cell but also mitochondria thereof. In addition, the system uses the gold nanoparticle having very little cytotoxicity so as to be harmless to a human body, as well as reflects light at various wavelengths so that the position thereof within cells can be easily identified. Thus, the antibody delivery system is expected to be usefully employed in the diagnosis or treatment of diseases.
Patent CA-3140151-A1 (CA)
Inventor: LEUTWYLER ZACHARY W
IPC: F16L55/04
Filed: 2020-05-01
Abstract: A flow conditioning assembly comprising an integral elbow flow conditioner and a downstream flow conditioner. The elbow flow conditioner includes a pipe elbow with one or more flow conditioning elements. Each flow conditioning element includes one or more turning guides. Each turning guide is generally circular and radially spaced from one another and an inner surface of the elbow. Spaced vanes maintain the radial spacing of the turning guides. The vanes divide the radial space between the turning guides and pipe elbow into a plurality of flow channels that turn in generally the same direction as the inner surface of the pipe elbow. The downstream flow conditioner comprises a flow conditioning structure within a pipe element. The flow conditioning structure includes one or more flow guides of generally circular form radially spaced from one another and the pipe element. Spaced support vanes maintain the radial spacing of the flow guides.
Patent CA-3142643-A1 (CA)
Inventor: GU Yu
IPC: A61M11/00
Filed: 2020-06-15
Abstract: L'invention concerne un dispositif microfluidique comprenant : un premier substrat (402, 502, 602, 702, 802), présentant un premier côté d'assemblage (402a, 702a, 802a); et un second substrat (404, 504, 604, 704, 804), présentant un second côté d'assemblage (404a, 504a, 604a, 804a) pouvant être relié au premier côté d'assemblage (402a, 702a, 802a) pour assembler le premier substrat (402, 502, 602, 702, 802) et le second substrat (404, 504, 604, 704, 804) ensemble. Le premier côté d'assemblage (402a, 702a, 802a) et/ou le second côté d'assemblage (404a, 504a, 604a, 804a ) comporte(nt) un canal de chambre de fluide (406, 706, 806) et après que le premier substrat (402, 502, 602, 702, 802) et le second substrat (404, 504, 604, 704, 804) ont été reliés ensemble, le canal de chambre de fluide (406, 706, 806) forme une chambre de fluide comportant une entrée de fluide (408, 608, 708, 808) et une sortie de fluide (410, 510, 610, 710, 810). Le premier côté d'assemblage (402a, 702a, 802a) et/ou le second côté d'assemblage (404a, 504a, 604a, 804a) comportant le canal de chambre de fluide (406, 706, 806) comporte(nt) une rainure d'expansion de sortie (418, 518, 618, 718, 818, 818') adjacente à la sortie de fluide (410, 510, 610, 710, 810) et s'étendant en aval de celle-ci et au niveau de la sortie de fluide (410, 510, 610, 710, 810), un profil périphérique externe de la rainure d'expansion de sortie (418, 518, 618, 718, 818 818') est situé à l'extérieur d'un profil périphérique externe de la sortie de fluide (410, 510, 610, 710, 810).
Patent CA-3143030-A1 (CA)
Inventor: FOX BRIAN
IPC: A61K41/00
Filed: 2020-06-12
Abstract: L'invention concerne des méthodes pour le traitement du cancer ou de maladies néoplasiques et analogues, par l'administration de 4- [2-(4-amino-pipéridin-1-yl))-5-(3-fluoro-4-méthoxy-phényle))-1-méthyl-6-oxo -1,6-dihydro-pyrimidin-4-yl]-2-fluoro-benzonitrile (composé de Formule (I)) ou un sel pharmaceutiquement acceptable de celui-ci, et des compositions pharmaceutiques comprenant des composés utiles pour l'inhibition de la déméthylase-1 spécifique de la lysine (LSD-1) à des patients en ayant besoin. L'invention concerne en outre des procédés d'administration de compositions décrites dans la description à des patients ayant des cellules néoplasiques qui expriment RCOR2.
Patent CA-3143103-A1 (CA)
Title: Pyridine carbamates and their use as glun2b receptor modulators
Inventor: GELIN CHRISTINE
IPC: C07D413/06
Filed: 2020-06-12
Abstract: Pyridine carbamates, pharmaceutical compositions containing pyridine carbamates, and uses of the pyridine carbamates and pharmaceutical compositions for modulating GluN2B receptors and for treating diseases, disorders, and medical conditions mediated by GluN2B receptor activity.
Patent CA-3144398-A1 (CA)
Title: Systems and methods for a smart virtual queue
Inventor: LINGUANTI NICHOLAS
IPC: A63G7/00
Filed: 2020-06-23
Abstract: A system includes a virtual queue controller configured to receive an indication of a reduced capacity event from an amusement park attraction, determine a reduction in capacity of the attraction, identify each guest having a return time in a virtual queue of the attraction that is affected by the reduced capacity event, remove guests having affected return times from the virtual queue, and generate a reaccommodation time slot for the guests removed from the virtual queue, select two or more updated return times within the reaccommodation time slot for each of the guests removed from the virtual queue, provide a notification to each guest removed from the virtual queue requesting guest input to select a single updated return time from the two or more updated return times, and return each guest to the virtual queue upon receiving a corresponding selection of the single updated return time.
Patent CA-3145219-A1 (CA)
Title: Methane production apparatus, methane production method, carbon dioxide recovery apparatus, and carbon dioxide recovery method
Inventor: MATSUZAKI YOSHIO
IPC: C07C1/12
Filed: 2020-07-14
Abstract: A methane production apparatus includes: a holding unit configured to hold any one or both of: a metal organic framework containing any one or a plurality of chromium, copper, and magnesium, and storing carbon dioxide;  and potassium bicarbonate; and a hydrogen supply unit configured to supply hydrogen to the holding unit.
Patent CA-3146795-A1 (CA)
Inventor: FAGERLAND INGVAR
IPC: G05D1/02
Filed: 2020-05-29
Abstract: A method (200), computer program product and system for controlling movements of container handling vehicles (150) operating in a storage and retrieval system (10) comprising a grid structure with storage columns (105) and a corresponding rail system (108) above the storage columns (105) for guiding movements of the vehicles (150) adapted for transferring storage containers (106) to and from the storage (columns 105), where each vehicle (150) comprises a vehicle controller (410) connected to driving means (420) and sensors (430) for controlling movements of the vehicle (150) along the rail system (108) relative to movements of other vehicles (150). The method comprises different steps performed in the vehicle controller (410) of each vehicle (150). The steps comprises using a map (210) defining rail layout and traffic rules for where and when vehicles (150) can move on the rail system (108), and where the map is the same for all vehicles (150) operating in the storage and retrieval system (10); synchronizing (220) the vehicle controller (410) to a clock common for all vehicles (150); receiving an instruction from a master controller (400) instructing the vehicle (150) to move to a specified destination (230) on the rail system (108) relative to the map; letting the vehicle controller (410) determine a route to follow (240) on the rail system (108) from a current position of the vehicle (150) to the specified destination based on the map, the traffic rules, distance to other vehicles (150) and movements of the other vehicles (150); controlling the movements (260) of the vehicle (150) along the rails system (108) from its current position to the specified destination according to the determined route, and repeating the steps until the vehicle (150) has reached the specified destination.
Patent CA-3152591-A1 (CA)
Title: Lung cancer biomarkers and uses thereof
Inventor: GOLD LARRY
IPC: G01N33/574
Filed: 2009-09-09
Abstract: The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of lung cancer. In one aspect, the application provides biomarkers that can be used alone or in various combinations to diagnose lung cancer or permit the differential diagnosis of pulmonary nodules as benign or malignant. In another aspect, methods are provided for diagnosing lung cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, Col. 2, wherein the individual is classified as having lung cancer, or the likelihood of the individual having lung cancer is determined, based on the at least one biomarker value.
Patent CA-3153029-A1 (CA)
Title: Uricase amelioree et procede de traitement de l'hyperuricemie l'utilisant
Inventor: HUANG GUOFENG
IPC: C12N9/06
Filed: 2020-10-10
Abstract: L'invention concerne une uricase améliorée, un procédé de traitement de l'hyperuricémie l'utilisant, et une composition pharmaceutique comprenant l'uricase. L'uricase améliorée comprend une séquence d'acides aminés ayant au moins environ 90 % d'identité avec SEQ ID NO : 1, et la séquence n'est pas SEQ ID NO : 1.
Patent CA-3155068-A1 (CA)
Title: Drug combination containing tlr7 agonist
Inventor: XU HONGJIANG
IPC: C07D471/04
Filed: 2020-09-29
Abstract: A drug combination containing a TLR7 agonist. Specifically, a drug combination jointly using the compound of formula I acting as a TLR7 agonist and entecavir for the treatment of hepatitis B virus infection and a use thereof, the drug combination having a good anti-hepatitis B virus infection effect.
Patent CA-3155322-A1 (CA)
Title: Peptide mimetics of dkk3b and methods of use
Inventor: LEONARD JACK L
IPC: C07K7/06
Filed: 2020-10-29
Abstract: The invention provides highly potent and stable peptide mimetics of human DKK3b having numerous improved properties. The peptide mimetics of the invention are useful as therapeutics in the treatment of various diseases wherein inhibiting nuclear translocation of ?-catenin is therapeutic, including, but not limited to, cancer/proliferative, metabolic, osteoporosis, neurological, immunological, endocrinologic, cardiovascular, hematologic, and inflammatory diseases.
Patent CA-3155828-A1 (CA)
Title: Automatic device or tool for removing and installing means for fastening liners in a mill; method for installing the means for fastening a liner; method for removing the means for fastening a liner
Inventor: ELIAS CABRERA IGOR SEBASTIAN
IPC: B23P19/04
Filed: 2019-09-03
Abstract: The invention relates to an automatic device or tool (1) for removing and installing means for fastening liners in a mill, the configuration thereof allowing the performance of a task involved in the removal and/or insertion of the means for fastening the liner, such as cleaning, lubrication, installation, loosening, removal, tightening and final tightening, using the same device, by means of automatic operation and remote actuation. The device or tool comprises at least one base structure or frame (2); a torque actuator and transmission system (3) formed by a die (4) coupled by means of a movable coupling (5) to a drive shaft (6) of a torque actuator (7), such that said configuration allows the die (4) to move axially, thereby enabling a nut to be inserted into the die (4) automatically; and at least one washing and lubrication system (9) formed in the front area (8) of the arrangement of the die (4), which allows the threads of the fastening means to be washed and lubricated, using the same device or tool (1) of the invention.
Patent CA-3156676-A1 (CA)
Title: Silk fibroin-based microneedles and uses thereof
Inventor: KOSUDA KATHRYN M
IPC: A61K47/42
Filed: 2020-10-09
Abstract: Microneedle and microneedle devices including, e.g., silk fibroin-based microneedles tips for sustained dermal delivery of an anti-cancer agent and/or an immunomodulatory agent, as well as methods of manufacturing and using the same are described herein. In other embodiments, compositions and methods for burst-release or sustained-release administration of an anti-cancer agent and/or an immunomodulatory agent to provide an improved immune response to a cancer in a subject are described.
Patent CA-3157952-A1 (CA)
Inventor: HOLLAUS RALPH
IPC: A61K31/728
Filed: 2020-12-18
Abstract: A thiol-modified hyaluronan, wherein the thiol-modified hyaluronan comprises a plurality of modification groups with a thiol-group in the hyaluronan side-chains, wherein the modification group comprises an amino acid residue with basic side chain and a conjugated terminal naturally occurring amino-thiol as well as a sterile hydrogel composition comprising a crosslinked polymer, wherein the crosslinked polymer is an oxidation product of the thiol-modified hyaluronan and uses of the composition.
Patent CA-3161499-A1 (CA)
Inventor: LAYCOCK PHILLIP ANTHONY
IPC: A61P31/04
Filed: 2022-06-03
Abstract: The present invention concerns a composition for an implantable pharmaceutical composition prepared from components consisting only of calcium sulfate a-hemihydrate in combination with two antibiotics, vancomycin and gentamicin, for the treatment of infection in bone and soft tissue.
Patent CA-3162855-A1 (CA)
Inventor: PARK LEEN CHUL
IPC: B63B1/32
Filed: 2020-01-28
Abstract: La présente invention concerne un appareil de réduction de la résistance aux fluides pour un navire, et plus spécifiquement, un appareil de réduction de résistance aux fluides pour un navire, l'appareil pouvant réduire considérablement la résistance au frottement et la résistance aux vagues provoquées par l'eau de mer lorsqu'un navire navigue, ce qui permet d'obtenir une amélioration de la vitesse, une navigation stable et une économie de carburant. Selon la présente invention, un appareil de réduction de résistance aux fluides est disposé au-dessous de la ligne de tirant d'eau d'une coque d'un navire et permet au navire de continuer à avancer tout en introduisant de l'eau de mer à travers une partie proue du navire et en évacuant l'eau de mer vers l'arrière de sa poupe en utilisant la rotation d'une hélice de propulsion disposée sur la coque. Par conséquent, la présente invention peut réduire considérablement la résistance au frottement et la résistance aux vagues de l'eau de mer et peut ainsi obtenir l'effet d'amélioration de la vitesse et d'économie de carburant ainsi que l'amélioration de la capacité de navigation.
Patent CA-3167115-A1 (CA)
Inventor: JOLLY TANNER JON
IPC: C08L1/06
Filed: 2021-02-18
Abstract: The present disclosure provides compositions and methods of manufacture of a composite material. In an aspect, the composite material may comprise a cellulosic material and a binder material. In some cases, at least a portion of the cellulosic material may be delignified. In some cases, at least a portion of crystal structure of the cellulosic material may be maintained in the composite material. In some cases, the cellulosic material may comprise a plurality of pores. In some cases, the binder may comprise lime comprising calcium oxide or calcium hydroxide. In some cases, the binder may further comprise silicate.
Patent CA-3167194-A1 (CA)
Inventor: HOANG KIEN TUAN
IPC: A63B69/36
Filed: 2022-07-11
Abstract: Apparatus for practicing golf, in particular the chipping aspect. The apparatus may be provided as a portable installation or permanent installation for events or entertainment.  The apparatus is ideally suited for golfers who cannot attend a full golf course in all weather conditions or prefer to practice their chipping. Raised structures provide chipping and bunker surfaces with the cup as the target. The apparatus is arranged to return the ball to the golfer after every shot.