Patent SG-11201811478T-A (SG)
Title: Freeze-dried formulations of antibacterial protein
Inventor: YOON SEONG JUN
IPC: A61K47/18
Filed: 2017-01-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization MD 1111101110101011111 HO 1111101110111 Hill 010 111111111011011# International Bureau .. .... ..Yejd ..... .....!;,,, (10) International Publication Number (43) International Publication Date WO 2017/122114 Al 20 July 2017 (20.07.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 9/19 (2006.01) A61K 47/18 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 47/10 (2006.01) A61K 38/16 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 47/26 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, PCT/IB2017/050091 KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (22) International Filing Date: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 9 January 2017 (09.01.2017) NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (25) Filing Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (26) Publication Language: English ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 62/277,588 12 January 2016 (12.01.2016) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: INTRON BIOTECHNOLOGY, INC. TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, [KR/KR]; #1007, JungAng Induspia V 138-6 Sangdae- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, won-Dong, Jungwon-Gu, Gyeonggi-do, 462-120 (KR). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors: YOON, Seong Jun; #301 Shinhan Apt. LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Galak2-Dong, Songpa-Ku, Seoul, 138-807 (KR). JUN, GW, KM, ML, MR, NE, SN, TD, TG). — Soo Youn; #301 Shinhan Apt. Galak2-Dong, Songpa-Ku, — Seoul, 138-807 (KR). JUNG, Gi Mo; #301 Shinhan Apt. Published: _ Galak2-Dong, Songpa-Ku, Seoul, 138-807 (KR). KANG, — with international search report (Art. 21(3)) Sang Hyeon; #507-310 Jugong-5-danzi Apt., 27, Jam- = 138-225 — with sequence listing of description (Rule 5.2(a)) sil-Dong, Songpa-Ku, Seoul, (KR). part = = = = = (54) Title: FREEZE-DRIED FORMULATIONS OF ANTIBACTERIAL PROTEIN = Figure I = Auto-Scaled Chromatogram = = = _ _ _ 11 7r Il Il ei 11 Minutes I r ----- (57) : A freeze-dried formulation includes an antibacterial protein having killing activity specific to at least one of or all foi- l—I lowing species: Staphylococcus arlettae, Staphylococcus aureus, Staphylococcus auricularis, Staphylococcus carnosus, Staphylo - el coccus carprae, Staphylococcus chromogenes, Staphylococcus cohnii, Staphylococcus delphini, Staphylococcus epidermidis, Sta - 0 phylococcus equorum, Staphylococcus gallinarum, Staphylococcus hemolyticus, Staphylococcus hominis, Staphylococcus interme- ,,f dius, Staphylococcus kloosii, Staphylococcus lentus, Staphylococcus lugdunensis, Staphylococcus muscae, Staphylococcus pasteuri, Staphylococcus saprophyticus, Staphylococcus warneri, and Staphylococcus xylosus; a poloxamer; a sugar, and an amino acid.