Patent ES-2527166-T3 (ES)
Title: Nuevos péptidos de 4-amino-4-oxobutanoílo como inhibidores de la replicación viral
Inventor: PHADKE AVINASH
IPC: C07K5/06
Filed: 2009-12-10
Granted: 2015-01-21
Abstract: Un compuesto o sal farmacéuticamente aceptable del mismo, en el que el compuesto es: (2S,4R)-1-((S)-2-terc-butil-4-oxo-4-(piperidin-1-5 il)butanoil)-N-((1R,2S)-1-(ciclopropilsulfonilcarbamoil)-2- vinilciclopropil)-4-(2-(piridin-2-il)-8,9-dihidrofuro[2,3-h]quinolin-4-iloxi)pirrolidin-2-carboxamida; (152) (2S,4R)-1-((S)-2-terc-butil-4-morfolino-4-oxobutanoil)-N-((1R,2S)-1-(ciclopropilsulfonilcarbamoil)-2- vinilciclopropil)-4-(2-(piridin-2-il)-8,9-dihidrofuro[2,3-h]quinolin-4-iloxi)pirrolidin-2-carboxamida; (153) (2S,4R)-1-((S)-2-terc-butil-4-oxo-4-(piperidin-1-il)butanoil)-N-((1R,2S)-1-(ciclopropilsulfonilcarbamoil)-2- vinilciclopropil)-4-(7-metoxi-2-(piridin-2-il)quinolin-4-iloxi)pirrolidin-2-carboxamida; (165) (2S,4R)-1-((S)-2-terc-butil-4-oxo-4-(piperidin-1-il)butanoil)-4-(8-cloro-7-metoxi-2-(piridin-2-il)quinolin-4-iloxi)-N- ((1R,2S)-1-(ciclopropilsulfonilcarbamoil)-2-vinilciclopropil)pirrolidin-2-carboxamida; (179) (2S,4R)-1-((S)-2-terc-butil-4-morfolino-4-oxobutanoil)-4-(8-cloro-7-metoxi-2-(piridin-2-il)quinolin-4-iloxi)-N- ((1R,2S)-1-(ciclopropilsulfonilcarbamoil)-2-vinilciclopropil)pirrolidin-2-carboxamida; (180) (2S,4R)-1-((S)-2-terc-butil-4-(3,3-difluoropiperidin-1-il)-4-oxobutanoil)-4-(8-cloro-7-metoxi-2-(piridin-2-il)quinolin-4- iloxi)-N-((1R,2S)-1-(ciclopropilsulfonilcarbamoil)-2-vinilciclopropil)pirrolidin-2-carboxamida; (181) N-((3R,5S)-1-((S)-2-terc-butil-4-(3,3-difluoropirrolidin-1-il)-4-oxobutanoil)-5-((1R,2S)-1- (ciclopropilsulfonilcarbamoil)-2-vinilciclopropilcarbamoil)pirrolidin-3-il)-9H-carbazol-9-carboxamida; (183) (2S,4R)-1-((S)-2-terc-butil-4-(4,4-difluoropiperidin-1-il)-4-oxobutanoil)-4-(8-cloro-7-metoxi-2-(piridin-2-il)quinolin-4- iloxi)-N-((1R)-1-(ciclopropilsulfonilcarbamoil)-2-vinilciclopropil)pirrolidin-2-carboxamida; (194) N-((3R,5S)-1-((S)-2-terc-butil-4-(3,3-difluoropirrolidin-1-il)-4-oxobutanoil)-5-((1R,2S)-1- (ciclopropilsulfonilcarbamoil)-2-vinilciclopropilcarbamoil)pirrolidin-3-il)-2-fenilquinolin-4-carboxamida; (201) (2S,4R)-1-((S)-2-terc-butil-4-(3,3-difluoropirrolidin-1-il)-4-oxobutanoil)-4-(8-cloro-7-metoxi-2-(piridin-2-il)quinolin-4- iloxi)-N-((1R)-1-(ciclopropilsulfonilcarbamoil)-2-vinilciclopropil)pirrolidin-2-carboxamida; 206 (2S,4R)-1-((2S)-2-terc-butil-4-oxo-4-(2-(trifluorometil)pirrolidin-1-il)butanoil)-4-(8-cloro-7-metoxi-2-(piridin-2- il)quinolin-4-iloxi)-N-((1R)-1-(ciclopropilsulfonilcarbamoil)-2-vinilciclopropil)pirrolidin-2-carboxamida; 207 (2S,4R)-1-((S)-2-terc-butil-4-oxo-4-(4-(trifluorometil)piperidin-1-il)butanoil)-4-(8-cloro-7-metoxi-2-(piridin-2- il)quinolin-4-iloxi)-N-((1R)-1-(ciclopropilsulfonilcarbamoil)-2-vinilciclopropil)pirrolidin-2-carboxamida; 208 (2S,4R)-1-((2S)-2-terc-butil-4-(3-fluoropiperidin-1-il)-4-oxobutanoil)-4-(8-cloro-7-metoxi-2-(piridin-2-il)quinolin-4- iloxi)-N-((1R)-1-(ciclopropilsulfonilcarbamoil)-2-vinilciclopropil)pirrolidin-2-carboxamida; 209 (2S,4R)-1-((S)-2-terc-butil-4-(3,3-difluoropirrolidin-1-il)-4-oxobutanoil)-N-((1R)-1-(ciclopropilsulfonilcarbamoil)-2- vinilciclopropil)-4-(7-metoxi-2-(piridin-2-il)quinolin-4-iloxi)pirrolidin-2-carboxamida; 214 (2S,4R)-1-((S)-2-terc-butil-4-oxo-4-(4-(trifluorometil)piperidin-1-il)butanoil)-N-((1R)-1-(ciclopropilsulfonilcarbamoil)- 2-vinilciclopropil)-4-(7-metoxi-2-(piridin-2-il)quinolin-4-iloxi)pirrolidin-2-carboxamida; 215 (2S,4R)-1-((S)-2-terc-butil-4-(4,4-difluoropiperidin-1-il)-4-oxobutanoil)-N-((1R)-1-(ciclopropilsulfonilcarbamoil)-2- vinilciclopropil)-4-(7-metoxi-2-(piridin-2-il)quinolin-4-iloxi)pirrolidin-2-carboxamida; 216 (2S,4R)-1-((S)-2-terc-butil-4-(3,3-difluoropiperidin-1-il)-4-oxobutanoil)-N-((1R)-1-(ciclopropilsulfonilcarbamoil)-2- vinilciclopropil)-4-(7-metoxi-2-(piridin-2-il)quinolin-4-iloxi)pirrolidin-2-carboxamida; 217 (2S,4R)-1-((S)-2-terc-butil-4-(4-fluoropiperidin-1-il)-4-oxobutanoil)-N-((1R)-1-(ciclopropilsulfonilcarbamoil)-2- vinilciclopropil)-4-(7-metoxi-2-(piridin-2-il)quinolin-4-iloxi)pirrolidin-2-carboxamida; 218 (2S,4R)-1-((2S)-2-terc-butil-4-(3-fluoropiperidin-1-il)-4-oxobutanoil)-N-((1R)-1-(ciclopropilsulfonilcarbamoil)-2- vinilciclopropil)-4-(7-metoxi-2-(piridin-2-il)quinolin-4-iloxi)pirrolidin-2-carboxamida; 219 (2S,4R)-1-((S)-2-terc-butil-4-(3,3-difluoroazetidin-1-il)-4-oxobutanoil)-N-((1R)-1-(ciclopropilsulfonilcarbamoil)-2- vinilciclopropil)-4-(7-metoxi-2-fenilquinolin-4-iloxi)pirrolidin-2-carboxamida; 223 (2S,4R)-1-((S)-2-terc-butil-4-(3-cloroazetidin-1-il)-4-oxobutanoil)-N-((1R)-1-(ciclopropilsulfonilcarbamoil)-2- vinilciclopropil)-4-(7-metoxi-2-fenilquinolin-4-iloxi)pirrolidin-2-carboxamida; 224 (2S,4R)-1-((S)-2-terc-butil-4-oxo-4-(piperidin-1-il)butanoil)-N-((1R)-1-(ciclopropilsulfonilcarbamoil)-2- vinilciclopropil)-4-(2-(4-isopropiltiazol-2-il)-7-metoxiquinolin-4-iloxi)pirrolidin-2-carboxamida; 230 (2S,4R)-1-((S)-2-terc-butil-4-oxo-4-(piperidin-1-il)butanoil)-N-((2S)-1-(ciclopropilsulfonilcarbamoil)-2- vinilciclopropil)-4-(8-metoxi-2-fenilquinolin-4-iloxi)pirrolidin-2-carboxamida; 231 (2S,4R)-1-((S)-2-terc-butil-4-(3,3-difluoropiperidin-1-il)-4-oxobutanoil)-N-((2S)-1-(ciclopropilsulfonilcarbamoil)-2- vinilciclopropil)-4-(2-(piridin-2-il)-8,9-dihidro-7H-ciclopenta[h]quinolin-4-iloxi)pirrolidin-2-carboxamida; 237 (2S,4R)-1-((S)-2-terc-butil-4-oxo-4-(4-(trifluorometil)piperidin-1-il)butanoil)-N-((2S)-1-(ciclopropilsulfonilcarbamoil)- 2-vinilciclopropil)-4-(2-(2-(isopropilamino)tiazol-4-il)-7-metoxi-8-metilquinolin-4-iloxi)pirrolidin-2-carboxamida; 238 (2S,4R)-1-((S)-2-terc-butil-4-oxo-4-(piperidin-1-il)butanoil)-N-((2S)-1-(ciclopropilsulfonilcarbamoil)-2- vinilciclopropil)-4-(7-metoxi-8-metil-2-fenilquinolin-4-iloxi)pirrolidin-2-carboxamida; 239 (2S,4R)-1-((S)-2-terc-butil-4-oxo-4-(4-(trifluorometil)piperidin-1-il)butanoil)-N-((1R)-1-(ciclopropilsulfonilcarbamoil)- 2-vinilciclopropil)-4-(7-metoxi-8-metil-2-fenilquinolin-4-iloxi)pirrolidin-2-carboxamida; 240 (2S,4R)-1-((S)-2-terc-butil-4-(3,3-difluoropiperidin-1-il)-4-oxobutanoil)-N-((2S)-1-(ciclopropilsulfonilcarbamoil)-2- vinilciclopropil)-4-(7-metoxi-8-metil-2-fenilquinolin-4-iloxi)pirrolidin-2-carboxamida; 241 (2S,4R)-1-((S)-2-terc-butil-4-oxo-4-(piperidin-1-il)butanoil)-N-((2S)-1-(ciclopropilsulfonilcarbamoil)-2- vinilciclopropil)-4-(2-(piridin-2-il)-8,9-dihidro-7H-ciclopenta[h]quinolin-4-iloxi)pirrolidin-2-carboxamida; 242 (2S,4R)-1-((S)-2-terc-butil-4-(3,3-difluoropiperidin-1-il)-4-oxobutanoil)-4-(5-cloro-6-metoxi-3-(piridin-2- il)isoquinolin-1-iloxi)-N-((2S)-1-(ciclopropilsulfonilcarbamoil)-2-vinilciclopropil)pirrolidin-2-carboxamida; 244 (2S,4R)-1-((S)-2-terc-butil-4-(3,3-difluoropiperidin-1-il)-4-oxobutanoil)-N-((2S)-1-(ciclopropilsulfonilcarbamoil)-2- vinilciclopropil)-4-(7-metoxi-8-metil-2-(piridin-2-il)quinolin-4-iloxi)pirrolidin-2-carboxamida; 236