baber/WOPTO huggingface dataset:
Patent EP-0956036-A1 (EP)
Inventor: GEESIN JEFFREY C
IPC: A61K38/00
Filed: 1997-10-24
Abstract: A novel method has been developed for screening anti-scarring and anti-fibrotic agents. This method offers simplicity, it is reproducible and could be adopted to screen a large number of new potential anti-fibrotic agents. This method has characteristics in common with the BAEC/BASMC co-culture system, but is more sensitive and does not require screening a large number of clonal lines for developing an effective method. In this system, similarly to the co-culture system, activation of L-TGF- beta 1 occurs by several independent mechanisms which involve binding of the latent complex to M6P/IGF-II receptors, thrombospondin and/or tissue type II transglutaminase. But, in contrast to the co-culture system, this macrophage-dependent system does not appear to involve plasmin. Using this method, potential novel anti-fibrotic agents such as IGF-II (used separately or in combination with IGFBP-2 as a delivery vehicle), tissue type II transglutaminase inhibitors and anti-inflammatory agents (such as hydrocortisone) were identified. A potential novel mechanism of action for Mannose 6-Phosphate has been proposed which is based on downregulation of M6P/IGF-II receptor and TGF- beta 1 mRNAs.
Patent EP-0888222-A1 (EP)
Inventor: CASTEGNIER ADRIEN
IPC: B41M7/00
Filed: 1997-12-26
Abstract: L'invention concerne un procédé et un appareil destinés à des impressions par électrocoagulation améliorées en vue de rendre l'encre imprimée résistante à l'eau. L'encre susceptible de coaguler par traitement électrolytique est électrifiée au moyen d'une électrode positive et d'une électrode négative; l'encre se trouvant entre les électrodes, positive et négative, est coagulée par traitement électrolytique de manière à former un point d'encre coagulée destiné à représenter une image. Le point d'encre coagulée est transféré sur le substrat afin de constituer l'image. On traite ce point d'encre coagulée avec un agent de réticulation afin de provoquer une réticulation avec un composant réticulable contenu dans l'encre coagulée, ce qui permet de rendre le point d'encre coagulée résistant à l'eau.
Patent EP-0950048-A1 (EP)
Inventor: BARONI MARCO
IPC: A61K31/445
Filed: 1997-12-12
Abstract: PCT No. PCT/FR97/02286 Sec. 371 Date Jul. 27, 1999 Sec. 102(e) Date Jul. 27, 1999 PCT Filed Dec. 12, 1997 PCT Pub. No. WO98/25903 PCT Pub. Date Jun. 18, 1998The invention relates to compounds of the formula in which: Y is -CH- or -N-; R1 is hydrogen, a halogen or a CF3, (C1-C4)alkyl or (C1-C4)alkoxy group; R2 is a methyl or ethyl group; R3 and R4 are each hydrogen or a (C1-C3)alkyl; and X is: (a) a (C1-C6)alkyl, a (C1-C6)alkoxy, a (C3-C7)carboxyalkyl, a (C1-C4)alkoxy-carbonyl(C1-C6)alkyl, a (C3-C7)carboxyalkoxy or a (C1-C4)alkoxycarbonyl-(C1-C6)alkoxy; (b) a radical selected from (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C3-C7)-cycloalkylmethyl, (C3-C7)cycloalkylamino and cyclohexenyl, it being possible for said radical to be substituted by a halogen, hydroxyl, (C1-C4)-alkoxy, carboxyl, (C1-C4)alkoxycarbonyl, amino or mono- or di-(C1-C4)-alkylamino; or (c) a group selected from a phenyl, phenoxy, phenylamino, N-(C1-C3)alkyl-phenylamino, phenylmethyl, phenylethyl, phenylcarbonyl, phenylthio, phenylsulfonyl, phenylsulfinyl and styryl, it being possible for said group to be monosubstituted or polysubstituted on the phenyl group by a halogen, CF3, (C1-C4)alkyl, (C1-C4)alkoxy, cyano, amino, mono- or di-(C1-C4)alkyl-amino, (C1-C4)acylamino, carboxyl, (C1-C4)alkoxycarbonyl, aminocarbonyl, mono- or di-(C1-C4)alkylaminocarbonyl, amino(C1-C4)alkyl, hydroxy(C1-C4)alkyl or halogeno(C1-C4)alkyl; to a method of preparing them and to the pharmaceutical compositions containing them. These compounds have neurotrophic and neuroprotective activity.
Patent EP-0944440-A1 (EP)
Inventor: LESAGE PATRICK
IPC: B05C17/015
Filed: 1997-12-23
Abstract: La présente invention a pour objet un dispositif de distribution d'une matière extrudable du type comprenant un réservoir, un embout séparable, un piston coulissant dans le réservoir pour refouler la matière à l'extérieur et une embase portant des moyens de commande en déplacement du piston. Selon l'invention, ledit embout (7) est tubulaire, ladite embase (1) comporte un élément formant plaque (11) disposé dans un plan sensiblement orthogonal à la direction de déplacement dudit piston (2), ladite plaque (11) présentant un passage (12) apte à recevoir ledit embout (7) et disposé en regard de l'orifice (8) dudit réservoir (6), et en ce que ledit dispositif comprend en outre une pièce d'étanchéité (13) présentant d'une part, un orifice prolongeant le passage de ladite plaque (11) et d'autre part une face d'étanchéité (14) tournée vers ledit réservoir (6) et apte à coopérer avec l'orifice (8) dudit réservoir (6) en réalisant une étanchéité entre elle-même et la paroi dudit orifice sous l'effet du déplacement dudit réservoir (6) vers la dite plaque (11) en réponse au déplacement dudit piston (2) dans ledit réservoir (6), et à être aisément séparée de la paroi dudit orifice sous l'effet du déplacement dudit réservoir dans un sens opposé à ladite plaque (11) des moyens pour réaliser une liaison étanche entre ledit embout et ladite pièce d'étanchéité, au moins sous l'effet du déplacement dudit réservoir (6) vers ladite plaque (11), des moyens pour immobiliser ladite pièce d'étanchéité par rapport à ladite plaque (11), au moins sous l'effet du déplacement dudit réservoir (6) vers ladite plaque (11).
Patent EP-0948558-A1 (EP)
Inventor: HAFFNER WILLIAM B
IPC: A61L15/22
Filed: 1997-12-17
Abstract: L'invention concerne des films respirants microporeux à orientation uniaxiale, ayant une ténacité exceptionnelle dans le sens transversal par rapport à la direction de l'orientation. Ces films comprennent un matériau de remplissage particulaire et un matériau non élastique. Ce dernier comprend un copolymère constitué d'éthylène et d'au moins un monomère d'α-oléfine C4-C8, tel que les copolymères désignés dans le commerce par les termes de 'extra-dur', 'nouvelle génération', etc., et il est préparé avec des systèmes catalyseurs 'nouveaux' ou 'améliorés' ou bien avec des catalyseurs à base de métallocènes ou des catalyseurs à site unique similaires. L'invention concerne également un procédé de fabrication.
Patent EP-0841579-A1 (EP)
Inventor: SCHUERMANN JOSEF H
IPC: G01S13/78
Filed: 1993-04-29
Abstract: A remote identification and sensor system is provided,
wherein compensation for measurement errors due to transponder
heat-up is performed. The system comprises an interrogator
for transmitting an interrogation signal, a transponder
(25) for receiving the interrogation signal, for performing
a sensor measurement and for transmitting a response signal
in response to the interrogation signal, an antenna (26) for
receiving the interrogation signal and for transmitting the
response signal in response, a rectifying element (30) connected
in series with the antenna (26) for rectifying the
interrogation signal, a storage element (32) connected in
series with the antenna (26) for storing a predetermined
amount of the rectified interrogation signal, a current
sensing over-voltage protection circuit (34, 36) connected
in parallel with the series combination of the antenna (26)
and the storage element (32), comprising a series combination
of an over-voltage protection element (34) and a current
sensing element (36), and a circuit element (38) for
making a sensor measurement, and for compensating the sensor
measurement, and for generating a response signal, having
two inputs with one input connected in series with the
rectifying element (30) and the second input connected
between the over-voltage protection element (34) and the
current sensing element (36).
Patent EP-0874043-A1 (EP)
Inventor: BRONESKE JUERGEN
IPC: A23K10/12
Filed: 1998-02-11
Abstract: Production of biomass by photosynthesis comprises inoculating a nutrient solution with microorganisms to obtain a culture suspension, conditioning the culture suspension with a CO2-containing gas until the suspension is saturated and free of bubbles, adjusting the pH to 5-7, adding an organic carbon source during the logarithmic to late stationary growth phase and passing the suspension through an illuminated reactor under uniform flow conditions.
Patent EP-0872777-A1 (EP)
Inventor: ONO TAKAHIRO
IPC: G03G15/00
Filed: 1998-04-16
Abstract: A sheet sorter includes an array of a plurality of
sorting trays which are mounted on a sorter body and
arranged in a vertical direction and a general-purpose tray
which is mounted on the sorter body and is larger than each
of the sorting trays in capacity so that it accommodates a
larger number of sheets than each of the sorting trays. A
tray drive mechanism provided in the sorter body moves up
and down the sorting trays and the general-purpose tray so
that sheets transferred by a transfer mechanism provided in
the sorter body are selectively discharged onto the sorting
trays or the general-purpose tray. The array of the
sorting trays is positioned above the general-purpose tray.
The sorting tray array and the general-purpose tray are
normally held in a position where the sheet discharge port
of the sheet transfer mechanism is positioned between the
lowermost tray of the sorting tray array and the general-purpose
tray as seen in a vertical direction.
Patent EP-0924402-A1 (EP)
Inventor: NOMURA TADASHI
IPC: F02B23/10
Filed: 1998-12-10
Abstract: In an arrangement for a spark-igniting direct-injection
internal combustion engine, a division of X by
B (X/B) (B denotes a cylinder bore diameter of each cylinder
and X denotes a distance from a fuel injection nozzle up
to a center axial line of the corresponding cylinder)
ranges from 0.38 to 0.46. A division of Y by B (Y/B) ranges
from 0.4 to 0.5 (wherein Y denotes a distance from a line
passing through a spark-ignition portion of a spark plug
up to an injection nozzle of the fuel injection valve. A
division of Z by B (Z/B) ranges from 0.2 to 0.3 (wherein
Z denotes a distance from the nozzle of the fuel injection
valve up to a center of the intake valve).
Patent EP-0865834-A1 (EP)
Inventor: DE SOUZA CELSO RODRIGO
IPC: B08B9/02
Filed: 1998-01-22
Abstract: A method for the thermo-chemical dewaxing of a hydrocarbon
transmission conduit containing paraffin deposit, said
method comprising the steps of:
   (a) introducing into said conduit an emulsion which
comprises:
   an internal aqueous phase comprising an oxidizing
nitrogen salt, a reducing nitrogen salt and water,   an external organic phase comprising a non-polar
organic liquid, and   a delayed action activator for inducing the reaction
of said oxidizing nitrogen salt and said reducing nitrogen
salt;     (b) maintaining said emulsion in said conduit under
conditions sufficient to fluidize the paraffin deposit and
to generate nitrogen gas and heat from the reaction of said
oxidizing nitrogen salt and said reducing nitrogen salt;
and   (c) removing fluidized paraffin deposit from said
conduit; 
   wherein the delayed action activator is a linear,
aliphatic copolyanhydride solubilized in a polar organic
solvent.
Patent EP-0920862-A1 (EP)
Inventor: CULLINAN GEORGE JOSEPH
IPC: A61K31/445
Filed: 1998-11-11
Abstract: This invention provides methods which are useful for
the inhibition of the various medical conditions
associated with estrogen deprivation syndrome including
osteoporosis and hyperlipidemia utilizing compounds of
formula I:
Patent EP-0911096-A1 (EP)
Inventor: GACHER LAURENT
IPC: B22D11/06
Filed: 1998-10-14
Abstract: A nozzle for a continuous casting installation, notably casting between rolls, incorporates at its lower end two ears (18, 18') cut in its lateral wall opposite each other at the ends of a tubular portion (17) of its inner space. The ears (18, 18') include some vertical extensions (20, 20', 20) in their two upper angles (19, 19').
Patent EP-0994009-A1 (EP)
Inventor: PAGGI BRUNO
IPC: B62D33/06
Filed: 1998-10-16
Abstract: An agricultural machine, comprising:
     a pair of front wheels (12) and a pair of rear
wheels (14), rigidly connected to a main frame (16),   a control cab (18) mounted on the main frame
(16), and   suspension means placed between the cab (18) and
the main frame (16).   
     Said suspension means comprise a plurality of
actuators (20; 30, 32) for controlling the rotation of
the cab (18) with respect to the main frame (16) about
at least two axis orthogonal to each other. An
electronic control unit (24) is provided with sensor
means for detecting variations of the cab tilt angle
with respect to an horizontal reference direction. The
electronic control unit (24) is programmed for
controlling said actuators so as to maintain a constant
orientation of the cab (18) with respect to said
reference direction.
Patent EP-0971029-A1 (EP)
Inventor: TCHEOU ERIC
IPC: C11D17/00
Filed: 1998-08-24
Abstract: The present invention relates to a tablet formed by compressing a particulate
material, the particulate material comprising a surfactant and a highly soluble
compound, the highly soluble compound having a cohesive effect on the
particulate material. 
     In a further aspect of the invention there is provided a method of preparing an
aqueous solution of a laundry detergent for use in a washing machine, wherein
the aqueous solution of laundry detergent is formed by dissolving in water a
tablet formed by compressing a particulate material, the tablet comprising a
surfactant and a highly soluble compound, the highly soluble compound having
a cohesive effect on the particulate material.
Patent EP-0903470-A1 (EP)
Inventor: HEER SIEGFRIED
IPC: F01L1/344
Filed: 1998-09-10
Abstract: The device has an adjusting element (5) with two threaded sections (5a,b). The first section meshes with a threaded part (4a) of a component (4) fastened to the camshaft (1). The second meshes with a threaded part (6b) of the component carrying the drive pulley (6). The camshaft is connected to a flange (2) and this is connected to a sleeve-like part (7) on the electric motor (15) via connection elements (8), through which the drive pulley passes.
Patent EP-0960096-A1 (EP)
Inventor: BURNS CHRISTOPHER
IPC: A61K31/4409
Filed: 1998-01-21
Abstract: This invention relates to compounds of general formula (I), wherein R?1 and R3¿ may be the same or different and each independently represents a group -L1-R5, where L1 is a direct bond, a straight or branched C¿1-6?alkylene chain, a straight or branched C2-6alkenylene chain, a straight or branched C2-6alkynylene chain or a straight or branched C1-6alkylene chain containing an oxygen or sulfur atom, a phenylene, imino (-NH-) or alkylimino linkage, or a sulfinyl or sulfonyl group, in which each of the alkylene, alkenylene and alkynylene chains may be optionally substituted, the substituents chosen from alkoxy, aryl, carboxy, cyano, cycloalkyl, halogen, hereroaryl, hydroxyl, or oxo; and R?5¿ represents hydrogen, aryl, aroyl, carboxy or an acid bioisostere, cyano, cycloalkyl, cycloalkenyl, heterocycloalkyl, heteroaryl, arylalkoxycarbonyl, -NH-C(=O)-NH¿2?, -C=N-O-C(=O)-NH2, -C(=O)-NY?1Y2, -NY1SO¿2aryl, -NHR6, -SR6, or -OR?6; R2 and R4¿ may be the same or different and are each independently hydrogen or alkyl; or R?2 and R4¿ together form a bond; or R?1 and R2, or R1 and R3, or R3 and R4¿ together with the carbon atom(s) to which they are attached form a 3 to 8 membered cycloalkyl or cycloalkenyl ring, optionally substituted by alkyl, arylalkyl, or heteroarylalkyl, and which may optionally contain a heteroatom selected from O, S or NR?6; or R1 and R3¿ together with the carbon atoms to which they are attached form a heteroaryl ring; Y represents carboxy or an acid bioisostere; A1 represents a direct bond, a straight or branched C¿1-4?alkylene chain or a NR?6¿ group; Ar is a group chosen from (i) and (ii) and n is 0, 1 or 2; and N-oxides thereof, and their prodrugs, pharmaceutically acceptable salts, and solvates (e.g. hydrates), thereof. Such compounds inhibit the production or physiological effects of TNF and inhibit cyclic AMP phosphodiesterase. The invention is also directed to pharmaceutical compositions comprising compounds of formula (I), their pharmaceutical use and methods for their preparation.
Patent EP-0958282-A1 (EP)
Inventor: LOWE JOHN ADAMS III
IPC: A61K31/4439
Filed: 1998-01-29
Abstract: This present invention relates to compounds of formula (I) wherein G, R?1 and R2¿ are defined as in the specification that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and to their use in the treatment and prevention of central nervous system and other disorders.
Patent EP-0955854-A1 (EP)
Title: Thermal treatment unit for food products
Inventor: CHAMPALAUNE JEAN-CLAUDE
IPC: A47J27/20
Filed: 1998-01-14
Abstract: The invention concerns a unit comprising a horizontal base plate (3) for bearing the products (5') to be treated, consisting of a sealed flat caisson, the upper wall of which (30) is at least thermally conductive, inside which it is possible to circulate a heat transferring fluid (FC), said base plate being integral with support elements (2) for stacking several units (1) on top of one another while maintaining their base plates (3) spaced from one another by a predetermined distance. The invention is useful for the thermal treatment of food products, in particular cold meats, particularly for cooking, cooling or refrigerating them.
Patent EP-0956658-A1 (EP)
Inventor: SIH GILBERT C
IPC: H04B3/23
Filed: 1998-01-27
Abstract: A method and apparatus for controlling various functional elements (34, 38, 42, 44) in a digital telephone system using state determination from an echo canceller (10). An echo canceller (10) is used to evaluate which one of five talk states two speakers are engaged in during a telephone conversation. This state determination information is used to control a tone detector function (34), a noise suppressor function (38), an adaptive equalizer function, a transmission mute function (42), and a vocoder encoder function (44) within a vocoder (12). During the talk state where the far-end speaker is active and the near-end speaker is inactive, the echo canceller (10) provides a signal which disables background noise estimates from being performed in the noise suppressor (38) and the vocoder (10) encoder. The same signal is used to disable the tone detector (34) and to enable the transmission mute function (42) during this talk state.
Patent EP-0917521-A1 (EP)
Inventor: STEKETEE JACOB JACOBUS
IPC: A62D3/02
Filed: 1998-03-06
Abstract: The invention relates to a method for in-situ immobilisation of heavy metals and/or sulphate in water-containing zones by microbiological preparation of sulphide using sulphate-reducing bacteria, a substrate for the sulphate-reducing bacteria being introduced into the zone and the density of the substrate at the temperature prevailing in the zones differing by at least 10 % from the density of the water present in the zones.
Patent EP-0983981-A1 (EP)
Inventor: MATSUMOTO TAKASHI
IPC: C04B41/50
Filed: 1998-03-30
Abstract: A carbon/silicon composite material wherein a
silicon carbide containing carbon layer which is
formed by silicon and boron carbide being penetrated
from a surface of a carbon substrate into the
inside thereof to allow the silicon and carbon of
the carbon substrate to react with each other so as
to be converted into silicon carbide and in which
the silicon carbide is dispersed generally
uniformly along a depth direction is formed on the
carbon substrate as a first layer, the silicon
carbide containing carbon layer having a thickness
of not less than 1 mm.
Patent EP-0972018-A1 (EP)
Inventor: JAMI JACQUES
IPC: A01K67/027
Filed: 1998-04-02
Abstract: L'invention concerne l'utilisation d'un animal mammifère transgénique non humain dans lequel l'un au moins des allèles de l'un au moins des deux gènes codant pour l'insuline endogène est rendu fonctionnellement inopérant vis-à-vis de l'expression de l'insuline pour la détermination de médicaments actifs, sur des pathologies impliquant l'insuline.
Patent EP-0975286-A1 (EP)
Inventor: WALKER PETER STANLEY
IPC: A61F2/30
Filed: 1998-04-15
Abstract: L'invention concerne une prothèse condylienne de remplacement total du genou, possédant des surfaces guides interactives qui permettent une commande de déplacement antérieur-postérieur. La prothèse comprend une pièce fémorale (1) comportant deux surfaces condyliennes (2, 3), une pièce tibiale comportant une plate-forme tibiale (4) et une pièce de support disposée entre les pièces fémorale et tibiale. Une surface guide fémorale (5) est située entre les condyles et coopère avec une surface guide tibiale (8) pour provoquer un déplacement postérieur de la pièce fémorale lors des mouvements de flexion et un déplacement antérieur lors des mouvements d'extension. La surface guide fémorale est décalée vers l'arrière et vers le bas à partir du centre de la courbe majeure des condyles fémoraux.
Patent EP-1011937-A1 (EP)
Title: Dispositif de coupe en largeur destine au bois et autres materiaux
Inventor: BLUM SVEN
IPC: B27B5/34
Filed: 1998-03-16
Abstract: L'invention concerne un dispositif de coupe destiné au bois et autres matériaux, comprenant un dispositif de serrage de lames de scie pour la fixation radiale et/ou axiale de lames de scie circulaire fixées sur un arbre d'entraînement et pouvant se déplacer axialement. Selon l'invention, des corps-supports (3) placés sur l'arbre d'entraînement (1) et pouvant se déplacer axialement sont respectivement destinés à au moins une lame de scie circulaire, p.ex. (2a). Le déplacement axial des lames de scie circulaire, p.ex. (2a), est assuré par des broches de transport, p.ex. (7), qui sont parallèles à l'axe de l'arbre d'entraînement et qui traversent les corps-supports, p.ex. (3). L'arbre d'entraînement (20) loge au moins un élément de serrage (21) qui est logé de manière à pouvoir se déplacer radialement. Lors de la première phase, les lames de scie circulaire, p.ex. (2a), portées par les corps-supports (3), sont déplacées par ledit élément de serrage (21). Lors de la deuxième phase, les lames de scie circulaire, p.ex. (2), ou les corps-supports, p.ex. (3), sont reliés par liaison de forme et/ou de force à l'arbre d'entraînement. Le dispositif de l'invention permet de régler la largeur de coupe sans un démontage coûteux en temps et en main d'oeuvre des lames de scie. Les corps-supports destinés aux scies circulaires sont plus étroits que les têtes de déplacement connues destinées aux scies circulaires à lames multiples. Cela permet de monter un plus grand nombre de lames de scie circulaire sur un axe.
Patent EP-1011609-A1 (EP)
Inventor: RON EYAL S
IPC: A61Q15/00
Filed: 1998-05-08
Abstract: Composition cosmétique comprenant un excipient acceptable sur le plan cosmétique qui contient un réseau polymère dont la viscosité est fonction de l'augmentation de la température comportant au moins un constituant poloxamère capable de s'agréger en réponse à un changement de température, lié de manière aléatoire à au moins un constituant acide polyacrylique, ainsi qu'un agent à activité cosmétique qui confère un effet cosmétique présélectionné, ledit excipient et ledit agent étant placés dans un milieu aqueux.
Patent EP-0997425-A1 (EP)
Inventor: OGAWA YUTAKA
IPC: B66B23/14
Filed: 1998-06-05
Abstract: An escalator system 11 has a plurality of steps 12
connected to chains 20 extending between upper sprocket wheels
18 disposed on an upper floor 15 and lower sprocket wheels 19
disposed on a lower floor 16, and travels along a circulating
path while maintaining the steps 12 in horizontal posture
through a transport region S5 for transporting users. The steps
circulate with riding surfaces 22 thereof constantly facing
upward, which allows the escalator system 11 to be made thin.