baber/WOPTO huggingface dataset:
Patent ES-8600678-A1 (ES)
Title: Tomato peeling device operating through vacuum and temperature
IPC: A23N7/00
Filed: 1984-11-15
Abstract: The present invention relates to a new and useful tomato peeling device which operates through vacuum and temperature and which by employing simple and common elements renders high performance and reduces manufacturing costs. The device is mainly comprised of an endless conveyor joined to two lateral chains guided by coaxial wheels travelling in a path of a rotary cylindrical drum which is connected to a vacuum pump, all of the cited elements being capable of treating fresh tomatoes and delivering pulp devoid of skin.
Patent ES-8607238-A1 (ES)
Title: Di:hydro-pyridine deriv. prepn.
IPC: C07D211/90
Filed: 1984-12-27
Abstract: The cpd. of formula (I) is made by (a) reacting m-nitro benzaldehyde with 2 equivs. isopropyl aceto-acetate and ammonia to give the cpd. of formula (II) (b) hydrolysing with 1 equiv. alkali hydroxide to obtain the salt of 2,6-dimethyl 5-isopropoxycarbonyl 4-(3-nitro phenyl) 1,4-dihydro pyridine 3-carboxylic acid of formula (III) in which M is Na or K and (c) reacting with CH3OCH2CH2X, in which X is Cl, Br, I, OSO2CH3 or other.
Patent ES-8606630-A1 (ES)
Title: Heat-transfer surfaces cleaning device for the intermediate body of a regenerative heat-exchanger.
IPC: F28G9/00
Filed: 1985-02-22
Abstract: The installation comprises a series of nozzles which are substantially tangentially directed and radially displaceably arranged before the front side of the storage mass (1) inside the heat exchanger, which nozzles let the supplied cleaning agent out of a cleaining agent source by directing the agent to the storage mass (1). The nozzles are provided on at least two nozzle heads (19, 17) arranged at a certain interval on a pipe (11, 13) extended substantially radially on one half of the front side of the storage mass (1), the pipe being sealed in the inner space of the heat exchanger and allowed to effect a reciprocating motion by means of a drive radially on the storage mass (1). By means of moving connections, the pipe (11, 13) is connected to at least one fixed outer conduit supplying the cleaning agent. The radially inner nozzle head (19) comprises, by reason of the reduced peripheral speed of the heat exchanger in this region, a number of nozzles smaller than that of the following nozzle head (17) located radially outwardly.
Patent ES-8700111-A1 (ES)
Title: Weld backup mechanism for internal pipe welding apparatus.
IPC: B23K37/06
Filed: 1985-04-16
Abstract: A weld backup mechanism includes an arcuate backup ring segment spring mounted to a support plate for rotational displacement. A plurality of such mechanisms are fixed to clamping members of an internal line-up clamp for radial expansion and retraction therewith.
Patent ES-8604227-A1 (ES)
Title: Aminomethyl-6-furo-[3,4-c]pyridine derivatives, process for their preparation and pharmaceutical compositions containing them.
IPC: C07D491/048
Filed: 1985-06-05
Abstract: 1,3-Dihydro-6-aminomethyl -7-hydroxy furo-(3,4-c) pyridines of formula (I) and their salts are new. In (I), A1 and A2 = H, 1-5C straight chain satd. or unsatd. hydrocarbon, a heterocycle with up to 6 members, a carbomonocyclic gp., phenyl alkyl or phenylalkenyl, any of which may be substd. by Cl, F, CF3, 1-5C alkyl, alkoxy or alkylthio, di(1-5C)alkylamino, di(1-5C)alkylamino (1-5C)alkoxy, alpha or beta (1-5C)alkoxy-N-pyrrolidinyl; R1 and R2 = H, methyl or ethyl but are not both H, or R1 and R2 together with the N atom form a pyrrolidine, piperidine, morpholine or thiomorpholine gp. - Prepn. comprises a condensation of (II) and (III) then debenzylating to produce (I). The condensation is effected in a non-polar solvent at a temp. below 20 deg.C. Debenzylation is effected by acid hydrolysis.
Patent ES-8609665-A1 (ES)
Title: Illumination system reflector.
IPC: G02F1/1335
Filed: 1985-07-15
Abstract: An illumination system reflector (18) which provides maximum energy to an aperture (25) with high uniformity and at high efficiencies, the reflector (18) being particularly adapted for use in liquid crystal light valve projection systems. A discharge lamp (34) is utilized in conjunction with an elliptical reflector (18), the axis of the reflector between the primary and secondary focus being tilted at an angle ( theta ) to the lamp axis. The axis of the ellipse (22) is displaced from the lamp axis a predetermined amount (DH), the combination of tilt ( theta ) and displacement (DH) being effective to increase illumination uniformity and efficiency at the aperture (25). Other system parameters, such as throw distance (CTHRO) and cone angle ( alpha ) also affect uniformity and efficiency for a typical design in which the parameters are selected to provide an optimized system being disclosed. A computer program simulation may be utilized for parameter selection. The vertical displacement (DH) parameter is shown to be related to the lamp envelope dimensions.
Patent ES-8701402-A1 (ES)
Title: Spot-shaped optical smoke detector
IPC: G08B17/10
Filed: 1985-09-06
Abstract: The present invention relates to a novel, optical smoke detector based on the diffusion from a luminous point source the diffusion variation of which is sensed by a suitably oriented phototransistor with specific sensitivity. The detector is characterised by: - two pulse-type light point sources placed in a black box with baffles - a suitably oriented receiver phototransistor intended for receiving the diffused light - an electronic velocimetric circuit for detection - an electronic circuit distinguishing between an alarm and a fault phenomenon. The present invention is used for detection of smoke and combustion gas in various premises such as factories, shops, depots, archives, dwellings, etc.
Patent ES-8605562-A1 (ES)
Title: Hydrolysis-stable flame retardant based on ammonium polyphosphate.
IPC: C09K21/04
Filed: 1985-10-15
Abstract: 1. Flame-retardant agent based on free flowing pulverulent ammonium polyphosphate of the general formula see diagramm : EP0178554,P12,F1 in which n stands for a whole number having an average value of about 20 to 800 and the ratio m/n is about 1 consisting of a) about 75 to 99.5 wgt % ammonium polyphosphate and b) about 0.5 to 25 wgt % of a reaction product of a polyhydroxy compound and a polyisocyanate, the polyurethane formed encapsulating the individual ammonium polyphosphate particles.
Patent ES-8800361-A1 (ES)
Title: Method of producing interferon-gamma.
IPC: C12N9/28
Filed: 1986-01-30
Abstract: A method of producing interferon- gamma which comprises using, as the gene expression elements, a expression elements containing an alpha -amylase promoter region derived from a gram-positive bacterial strain and, as the host, a gram-negative bacterial strain. The invention has thus enabled production of interferon- gamma in gram-negative bacteria through the use of gene expression elements of a gram-positive bacterial strain and has contributed to technology diversification in the field of genetic engineering. On the occasion of the secretion of the interfteron- gamma into the periplasmic space of gram-negative bacteria, the signal peptide is cleaved off, whereby the protein is obtained in the form of a mature protein free of methionine at the N terminal.
Patent ES-8704144-A1 (ES)
Title: Method of producing high-density slurry/prill explosives in boreholes.
IPC: C06B47/14
Filed: 1986-03-11
Abstract: The pneumatic loading of essentially free-flowing slurry-bearing ammonium nitrate (AN) prills, i.e., AN prills which carry or support a water gel or water-in-oil emulsion, produces a high-density explosive consisting of the tightly packed whole and crushed slurry-bearing prills. The density of this explosive can be as much as 20% higher than the poured density of the mass of slurry-bearing prills.
Patent ES-8801189-A1 (ES)
Title: Heterocyclic compounds, their production, and medicaments containing them.
IPC: C07D275/03
Filed: 1986-06-25
Abstract: Compounds of formula I < CHEM > and salts thereof are useful for the treatment and prophylaxis of allergic diseases. Production and use of the compounds is described.
Patent ES-8800959-A1 (ES)
Title: Amino acid derivatives, process for their preparation and pharmaceutical compositions.
IPC: C07K5/068
Filed: 1986-08-08
Abstract: The amino acid derivatives have the general formula < IMAGE > in which R<1> is H, acetyl, benzoyl, pivaloyl or the radical < IMAGE > P is one of the numbers 1-4 A is a residue of one of the alpha -amino acids < IMAGE > or < IMAGE > R2 is hydrogen, C1-C4-alkyl, straight-chain or branched, C5-C7-cycloalkyl, it being possible for a phenyl ring to be fused on, phenyl, phenyl-C1-C4-alkyl, a hetero-C1-C4-alkyl radical where the heterocycle consists of a 5- or 6-membered ring with 1-2 of the hetero atoms O, S or N, R3 is hydrogen, C1-C4-alkyl, straight-chain or branched, phenyl, phenyl-C1-C4-alkyl or a hetero-C1-C4-alkyl radical where the heterocycle consists of a 5- or 6-membered ring with 1-2of the hetero atoms O, S or N, or R2 and R3 together form with the N and the C atom a 5-, 6- or 7-membered ring which can be saturated or contain one double bond, or a 4-, 5- or 6-membered ring which contains one or more of the hetero atoms O, S or N R4 is OH, C1-C4- omega -hydroxyalkyl, C1-C4-alkoxy, phenyl-C1-C4-alkoxy, C1-C4-alkylamino, (C1-C4)2-dialkylamino, one of the groups < IMAGE > or an alpha -amino acid which is linked in the manner of a peptide to the CO group of the molecule R5 is C1-C4-alkyl, C1-C3-alkenyl, C1-C3-alkynyl, straight-chain or branched, hydroxyl, nitro, amino, C1-C4-alkoxy, mercapto, C1-C4- alkylthio, hydroxy-C1-C4-alkyl, mercapto-C1-C4-alkyl, F, Cl, Br, amino-C1-C4-alkyl, sulphonamido, methylenedioxy, fluoro-C1-C4-alkyl, chloro-C1-C4-alkyl, bromo-C1-C4-alkyl, cyano or trifluoromethyl R6 is hydrogen or methyl R7 is C1-C4-alkyl, straight-chain or branched, where the alkyl radical can be substituted by F, Cl, Br, CF3, phenyl or pyridyl X, Y and Z are O, S, NR8, CR9, CHR9, < IMAGE > with the proviso that only one of the radicals X, Y and Z can be O, S, < IMAGE > and one or two of the radicals X, Y and Z can be NR8 R8 is hydrogen or C1-C4-alkyl, straight-chain or branched R9 is hydrogen or, together with a vicinal radical R9, a phenyl ring or, for m and n = 1, the dihydro form thereof with double bond in conjugation with the C-terminal carboxyl group and m and n are each 0, 1 or 2, where the total of m and n is 1 or 2. The compounds are strong inhibitors of angiotensin I converting enzyme and are intended for use as hypotensive agents.
Patent IE-901535-A1 (IE)
Title: Independent cooling chamber for multichip units
IPC: H01L23/00
Filed: 1990-04-27
Abstract: An independent cooling chamber for multichip units includes a housing defining a first chamber. The housing is secured to a multichip unit over at least one semiconductor chip that is a part of the multichip unit. An interface between the housing and the multichip unit includes a seal providing a fluid tight seal between the sides of the housing and the multichip unit, thus defining a first fluid tight chamber within which one or more semiconductor chips are located. A first coolant is provided in the first fluid tight chamber. The first coolant is in heat transfer relationship with the semiconductor chips located in the first fluid tight chamber. The housing includes a heat exchanger including a second chamber in heat transfer relationship with the first chamber. A second coolant is contained within the second chamber for transfer of heat from the first coolant.
Patent IE-912601-A1 (IE)
Title: Endogenously sweetened transgenic plant products
IPC: A23L27/30
Filed: 1991-07-23
Abstract: Edible fruit, seed and vegetables of transgenic plants modified to produce a sweetening protein such as monellin or thaumatin are useful in preparing food compositions which have enhanced sweetness improved flavor. Expression systems for the genes encoding sweetening proteins compatible with plant systems and designed to enhance the production of these proteins in the edible portions of plants, and methods for producing sweetened fruit, seeds and vegetables are described.
Patent IE-912769-A1 (IE)
Title: Gonadoliberin antagonists
Inventor: KOENIG WOLFGANG
IPC: A61P5/00
Filed: 1991-08-02
Abstract: Peptides of the formula in which X is alkanoyl, A is optionally substituted D-Na(2), D-Phe or D-Trp, B is optionally substituted D-Phe, C is D-Pal(3) or optionally substituted D-Phe or D-Trp, and D is Tyr or His, E is D-Ser(R<1>), F is Leu, Trp or Phe, G is L-Ser(R<1>), H is Gly-NH2, D-Ala-NH2 or azagly-NH2 and R<1> is a glycosyl radical, have inhibitory effects on the formation of the gonadotropins lutropin and follitropin and thus also on the synthesis of testosterone and oestrogen. A process for the preparation of these peptides is described.
Patent IE-922287-A1 (IE)
Title: Production of antibodies
Inventor: CROWE JAMES SCOTT
IPC: C12N15/13
Filed: 1992-07-14
Abstract: This invention relates to the preparation of recombinant primate antibodies by DNA technology; Micro-RNA techniques for production of the same; recombinant non-human primate antibodies; formulations containing the same; the use of such antibodies in the prophylaxis and treatment of humans, and diagnostic uses of such antibodies.
Patent WO-0076712-A1 (WO)
Title: Device for pre-drying the welding area of a welding die
Inventor: KOBLMUELLER GUENTHER
IPC: E01B11/52
Filed: 2000-05-29
Abstract: A device for pre-drying the welding area of a welding die (F) for metal-heat welding of the ends of rail joints, comprising a frame (1',1 ) which can be placed on the upper side of the welding die and which has a part (1 ) which extends vertically in an upwards direction, surrounding the pouring gate (E) of said die. Said frame part includes a preferably copper conduit arrangement (R) which comprises, from top to bottom, a holder (2) for a gas cartridge (3), preferably a liquid gas cartridge, a stop-valve (4) and an evaporation unit (5',5 ) and which is provided with a burner (6) on the lower end, placed at a distance from the pouring gate.
Patent AT-507506-A1 (AT)
Title: Hand lever wastage press for disposal of e.g. aerosol can, has press plate guiding unit utilized for adjusting distance between base plate and press plate to press goods, and breakage wedge integrated in press plate
IPC: B30B9/32
Filed: 2009-03-02
Abstract: The press has a press plate guiding unit utilized for adjusting distance between a base plate and a press plate (3), to press goods, which are pressed together between a base plate and the press plate. A breakage wedge (12) is integrated in the press plate. The wedge is expanded from the press plate via a traction strap (17). A tilting securing tube and a lever tube are integrated in the base plate. The guiding unit is hinged parallel to the base plate in a stowage position via a fulcrum disk, and locked in a press position in an expanded manner around 90 degree.
Patent AT-518025-A1 (AT)
Title: Stopfaggregat und Verfahren zum Unterstopfen eines Gleises
IPC: E01B35/00
Filed: 2015-12-10
Abstract: Ein Stopfaggregat (1) zum Unterstopfen von Schwellen (4) eines Gleises (14) weist um eine Schwenkachse (6) verschwenkbar auf einem Werkzeugträger (7) gelagerte, mit Stopfpickeln (2) verbundene Stopfhebel (3) auf. Diese sind durch hydraulische, mit einem Vibrationserreger (18) verbundene Linearmo- toren (8) in einer Beistellbewegung (15) verschwenkbar. Jedem Stopfhebel (3) ist ein Winkelsensor (19) zur Erfassung eines Schwenkwinkels a in Bezug auf den Werkzeugträger (7) zugordnet
Patent WO-9210845-A1 (WO)
Inventor: GOES REINHARD
IPC: H01H33/26
Filed: 1991-12-04
Abstract: Des circuits et un récepteur de valeurs de mesure détectent et mesurent des sources de lumière, de préférence des arcs électriques dans des appareils commutateurs. Un émetteur optique (1) qui émet en continu ou périodiquement un signal pendant la période de mesure et un récepteur optique (3) sont reliés par une boucle de mesure et de contrôle (4). La boucle de mesure et de contrôle (4) se compose de deux guides d'ondes lumineuses (7, 8) entre lesquels est connecté un récepteur (9) optique de valeurs de mesure. Le récepteur de valeurs de mesure à connecter dans les circuits comprend une douille cylindrique (57) en plexiglas insérée sur la deuxième extrémité (53) du premier guide d'ondes lumineuses (51) et sur la première extrémité (54) du deuxième guide d'ondes lumineuses (52). Les gaines (55, 56) des guides d'ondes lumineuses sont collées à la face interne de la douille (57). Les extrémités (53, 54) des guides d'ondes sont mutuellement espacées et disposées sur un axe longitudinal commun.
Patent WO-9220546-A1 (WO)
Inventor: WAWRA MANFRED
IPC: B60L11/18
Filed: 1992-05-08
Abstract: Eine elektronische Steuerschaltung für die Speisung von ohmisch-induktiven Lasten durch Gleichstromimpulse mit veränderbarem Tastverhältnis umfaßt einen Transformator (T) aufweisenden Steller, wobei der Transformator als Autotransformator mit einer einzigen durchgehenden Wicklung mit Mittelanzapfung und zu dieser symmetrischen Anzapfung ausgebildet ist, primärseitig über von Freilaufdioden überbrückte elektronische Schalter (Q3, Q4) in Gegentaktanordnung an eine Gleichspannungsquelle (B) angeschlossen ist und sekundärseitig über symmetrisch mit dem Transformator (T) verbundene, von Freilaufdioden überbrückte elektronische Schalter (Q5, Q6) mit der Last (M) in Verbindung steht. Zwischen dem Verbindunsspunkt der vom Transformator (T) abgewendeten Anschlüsse der sekundärseitigen elektronischen Schalter (Q5, Q6) und dem vom Transformator (T) abgewendeten Pol der Gleichspannungsquelle (B) ist wenigstens eine Reihenschaltung zweier von Freilaufdioden überbrückter elektronischer Schalter (Q1, Q2) angeschlossen, deren Freilaufdioden gegensinnig zu den Freilaufdioden der beiden sekundärseitigen elektronischen Schalter (Q5, Q6) liegen, wobei die Last (M) parallel zu einem (Q1) der in Reihe geschalteten elektronischen Schalter angeschlossen ist.
Patent WO-9317845-A1 (WO)
Inventor: HAUNOLD FRITZ
IPC: B27N3/06
Filed: 1993-03-04
Abstract: Procédé de fabrication d'un corps en résine synthétique façonné par compression, consistant (a) en une phase de préimprégnation et (b) en une phase d'imprégnation. Au cours de l'opération (a), des matériaux fibreux sont mélangés intimement, de manière regulière, avec un haut à base d'une résine de condensation dans la conduite de soufflage (3), puis lesdits matériaux sont séchés dans un courant d'air chaud (6), de manière que leur humidité résiduelle soit de 6 % maximum. Au cours de l'opération (b), les fibres de bois préimprégnées sont déposées en vrac (10) sur une bande transporteuse (12), et sont ensuite recouvertes des deux côtés avec des papiers de séparation (25, 25') qui sont eux-mêmes recouverts d'un côté, du liant réalisé à base de résine de condensation. La structure en couches (19) ainsi obtenue est comprimées de manière continue à une température plus élevée, pour atteindre une masse spécifique moyenne normale compris entre 900 et 1200 kg/m3, de manière à ce que le liant pénètre complétement à l'intérieur de la masse fibreuse où il est ensuite durci.
Patent WO-9851156-A1 (WO)
Title: Backofen für die herstellung von dünnwandigen formkörpern mit jeweils aus zwei formhälften bestehenden, auf- und zumachbaren backformen
Inventor: HAAS FRANZ SEN
IPC: A21B5/02
Filed: 1998-05-11
Abstract: Backofen für die Herstellung von dünnwandigen Formkörpern in auf- und zumachbaren Backformen, die von stapelbaren Backplatteneinheiten gebildet werden, die an ihren Oberseiten die unteren Formhälften und an ihren Unterseiten die oberen Formhälften der Backformen tragen. Einer unteren Beschickungsstation, in der ein Vorprodukt auf die Oberseiten jeder Backplatteneinheit aufgebracht wird, ist ein vertikaler Backschacht nachgeordnet, der einen aus lose aufeinanderliegenden Backplatteneinheiten bestehenden, vertikalen Stapel enthält, der sich auf einer unteren Haltevorrichtung abstützt. Dieser Stapel wird an seinem unteren Ende von einer Stapelvorrichtung durch fortlaufendes Hinzufügen einer mit Vorprodukt beschickten Backplatteneinheit fortlaufend neu gebildet und an seinem oberen Ende durch Wegnehmen einer Backplatteneinheit fortlaufend aufgelöst, so daß die lose aufeinanderliegenden Backplatteneinheiten und die von diesen gebildeten Backformen im Stapel schrittweise nach oben durch den Backschacht wandern, während in den Backformen die Vorprodukte zu dünnwandigen Formkörpern gebacken werden. Jede einzelne, von zwei aufeinanderliegenden Backplatteneinheiten gebildete Backform wird entgegen dem in ihr beim Backen entstehenden Innendruck nur durch das Gewicht des jeweils auf ihr lastenden Teiles des Stapels geschlossen gehalten, während sie im Stapel schrittweise nach oben zu einer Entnahmestation wandert, in der die gebackenen Formkörper von den Oberseiten der Backplatteneinheiten agbenommen werden.
Patent AU-2002213935-A1 (AU)
Title: Electromagnetically actuated valve system and valve device
Inventor: STUMPE WERNER
IPC: F16K31/40
Filed: 2001-09-19
Abstract: The invention relates to a valve system comprising a housing, an actuator, a main valve disposed between an inlet chamber and an outlet chamber, and a pilot chamber. Said pilot chamber is linked with the outlet chamber via a main valve, comprising at least one pilot valve member and one valve body linked with the electromagnetic actuator, and with the inlet chamber via at least one connecting channel. The invention is characterized in that the stationary seat of the main valve is formed by an insert that is mounted in the; housing of the valve system. The main valve member is impinged upon on its diametrically opposed surfaces by the pressure present in the inlet chamber and the pressure present in the pilot chamber. The pilot chamber is linked with the inlet chamber via a connecting channel that extends through the main valve member. The pilot valve member is formed by the insert mounted in the housing of the valve system or by the housing. The connection to the outlet chamber is made via at least one connecting channel disposed in the housing or in the insert.
Patent AU-2002214389-A1 (AU)
Title: Pharmaceutical composition containing honey for the treatment of wounds
Inventor: POSTMES THEODORE JUSTIN LOUIS
IPC: A61K9/06
Filed: 2001-10-12
Abstract: The present invention relates to a composition with a base of a therapeutically active compound, in particular honey, for the treatment of wounds. More in particular, the present invention relates to the use of a honey-containing composition for the preparation of a substance for the treatment of wounds.
Patent AU-2002222003-A1 (AU)
Title: Benzimidazole derivatives, preparation and therapeutic use thereof
Inventor: BARTH FRANCIS
IPC: A61P21/04
Filed: 2001-11-21
Abstract: The invention relates to benzimidazole derivatives of general formula (I) in which X represents a nitrogen atom or a carbon atom; and when X represents a nitrogen atom R3 represents in particular a hydrogen atom or a (C1-C4)alkyl group, R4 represents in particular a hydrogen atom; a (C1-C6)alkyl; (C3-C7)cycloalkyl; 4-piperidyl; -(CH<SUB>2</SUB>)<SUB>p</SUB>-NR5R6; -(CH<SUB>2</SUB>)<SUB>p</SUB>-CONR5R6; -CO-(CH<SUB>2</SUB>)<SUB>p</SUB>-NR5R6; -(CH<SUB>2</SUB>)<SUB>p</SUB>-phenyl; -(CH<SUB>2</SUB>)<SUB>p</SUB>-morpholinyl; -(CH<SUB>2</SUB>)<SUB>p</SUB>-pyrrolidinyl; -(CH<SUB>2</SUB>)<SUB>p</SUB>-tetrahydroisoquinoline; -(CH<SUB>2</SUB>)<SUB>p</SUB>-heteroaryl; heteroarylcarbonyl; phenylcarbonyl; (C1-C6)alkylcarbonyl; -(CH<SUB>2</SUB>)<SUB>p</SUB>-COOR'; or phenylsulphonyl group; and when X represents a carbon atom R3 represents a hydrogen atom; a group -NR5R6; -NHCOR7; -CONHR5; -COR7; -NHCONH<SUB>2</SUB>; -OH or -CH<SUB>2</SUB>OH, R4 represents in particular a hydrogen atom; an optionally substituted group -(CH<SUB>2</SUB>)<SUB>p</SUB>-phenyl; a group -(CH<SUB>2</SUB>)<SUB>p</SUB>-heteroaryl; or a group -(CH<SUB>2</SUB>)<SUB>t</SUB>NR7R8. Preparation process and therapeutic application.