baber/WOPTO huggingface dataset:
Patent SI-1622936-T1 (SI)
Title: Method for the production of an n-terminally modified chemotactic factor
Inventor: WANDL ROBERT
IPC: C12N5/071
Filed: 2004-04-13
Abstract: Preparing pyroGlu-MCP-1 (A; MCP = monocyte chemoattractant protein-1) from recombinant Gln-MCP-1 (B) by incubating (B) at 30-80 [deg] C in a buffer, of pH 2-7.5, that contains 10-160 mM salt until at least 90% of MCP-1 is converted to (A). ACTIVITY : Cardiant; Vasotropic; Cerebroprotective. MECHANISM OF ACTION : CCR2 agonist; CCR4 agonist. MCP-1 is an agonist of the beta -chemokine receptors CCR2 and 4, which are involved in activation of monocytes and adhesion of integrins, resulting in bonding of monocytes to endothelial cells. This causes extravasation of monocytes from the vascular system, and thus growth of collateral and/or other arteries.
Patent SI-1605891-T1 (SI)
Title: Connector for packings containing medical liquids, and corresponding packing for medical liquids
Inventor: BRANDERBURGER TORSTEN
IPC: A61J1/00
Filed: 2004-01-22
Abstract: The connector for bags and containers of medical fluids has a connector (1) to hold a spike for the fluid extraction, and a closure cap (3). The connection has a clamp section (4) with elastic distortion, in a tubular out-of-round shape. The clamp has an enlarged base (5), extending on both sides, to be integrated into the fluid packaging.  After filling, the clamp is compressed to prevent escape, and the closure cap is fitted. A self-sealing membrane (11) is between the closure cap and the connector.
Patent SI-1921144-T1 (SI)
Title: Method for linking sequences of interest
Inventor: OLEKSIEWICZ MARTIN B
IPC: C07K16/00
Filed: 2004-09-17
Abstract: Multiplex overlap-extension RT-PCR provides an efficient method of linking two or more nucleotide sequences encoding for domains or subunits of a heteromeric protein, in a single reaction. Especially, the linkage of variable region encoding sequences from e.g. immunoglobulins, T cell receptors or B cell receptors is eased with the method of the present invention. This allows for a more efficient way of generating libraries of variable region encoding sequences. The capability to perform the multiplex overlap-extension RT-PCR using template derived from an isolated single cell enables the generation of cognate pair libraries in a high-throughput format.
Patent SI-2333044-T1 (SI)
Title: Pharmaceutically compatible method for purifying intact bacterial minicells
Inventor: BRAHMBHATT HIMANSHU
IPC: C12N1/00
Filed: 2004-06-23
Abstract: The present invention provides a method for purifying bacterial minicells that involves subjecting a sample containing minicells to density gradient centrifugation in a biologically compatible medium. The method optionally includes a preliminary differential centrifugation step and one or more filtration steps. The invention also provides a method for purifying bacterial minicells in which a sample containing minicells is subjected to a condition that induces parent bacterial cells to adopt a filamentous form, followed by filtration of the sample to separate minicells from parent bacterial cells. The inventive methods optionally include one or more steps to remove endotoxin from purified minicell preparations, and/or treatment of purified minicell preparations with an antibiotic. Additionally, the invention provides purified minicell preparations, prepared according to the foregoing methods, and containing fewer than about 1 contaminating parent bacterial cell per 107, 108, 109, 1010, or 1011 minicells.
Patent SI-1691827-T1 (SI)
Title: Use of peptides derived from the b beta chain of human fibronogen for the treatment of shock
Inventor: PETZELBAUER PETER
IPC: A61K38/00
Filed: 2005-06-24
Abstract: The invention relates to the use of a peptide of general Formula I wherein R<SUB>1 </SUB>and R<SUB>2</SUB>, being equal or different, denote hydrogen, a saturated or unsaturated hydrocarbon moiety comprising from 1 to 10, in particular from 1 to 3, carbon atoms, Z<SUB>1 </SUB>denotes a histidine or proline moiety, Z<SUB>2 </SUB>denotes an arginine moiety, a peptide moiety or a protein moiety comprising an initial arginine moiety, in particular comprising from 2 to 30 amino acids, which peptide has the biological property of matching the inducible VE-cadherin binding motif on the Bbeta-chain (i.e. Bbeta<SUB>15-42</SUB>) of human fibrin, for the preparation of a pharmaceutical preparation for the treatment of shock.
Patent SI-2328539-T1 (SI)
Title: Smooth, high solids tablet coating composition
Inventor: TERZIAN LANA L
IPC: A61K9/00
Filed: 2009-09-24
Abstract: The invention describes a coating composition comprising an effective amount of a water- soluble cellulose ether, a poly(N- vinyl pyrrolidone-co-vinyl acetate) copolymer, a film- forming agent based on D-glucose, and a plasticizer.
Patent DE-3750705-T2 (DE)
Inventor: SHANKAR KAPIL
IPC: H03K19/177
Filed: 1987-01-30
Granted: 1995-05-18
Abstract: Method and apparatus providing a programmable logic device which has a high level counter element and a programmable AND array suitable for control applications. The method utilizes high level constructs bearing a one-to-one relationship to the architecture of the apparatus so that the design of the controller is facilitated resulting in a rapidly-executed program which is easy to comprehend, verify and document. Moore and Mealy state machines are readily implemented by the controller by virtue of its programmable AND array and counter which allow the next-state and output to be based on the contents of the counter as well as any set of input signals. Conditional testing can be made entirely state dependent, partially-state dependent, or state-independent Multiway branching is also readily implemented since the presence of the programmable AND array allows the user to specify a number of sets of input conditions, so that from a given state, as determined by the counter contents, each set of input condition gives rise to a transition to a specified next state. Instruction decoding for the controller is preformed in the programmable AND array, and thus can be specified by the designer in the high-level software method of the invention. Accordingly, instructions can be stored in the AND array in a logical form directly usable by the hardware. The counter is preferably of the Gray-code type so as to minimize instabilities in the output signals and to permit easy optimization of Boolean expressions involving the state of the device. Dedicated buried registers are provided as are dedicated feedback paths from the output registers, dedicated registers and counter to the AND array. Two separate OR arrays are provided, one generating output signals, the other generating control sequencing signals.
Patent DE-3785446-T2 (DE)
Inventor: BAKER GERALD S
IPC: F16K1/38
Filed: 1987-09-04
Granted: 1993-07-29
Abstract: A choke includes a body (12) with an internal valve chamber (18), an inlet (14) and an outlet (16) communicating through the body into the valve chamber. A valve seat (20) surrounds the opening of the outlet into the valve chamber, and a valve member (30) is mounted within said body to move toward and away from said valve seat to control flow therethrough. Means are provided for moving the valve member in the body. The valve member (30) has a stem (32) and a replaceable, wear-resistant tip (42) which is provided with a sleeve insert (48) secured within the stem opening and has internal threads which mate with external threads on the end of the stem. The tip recess includes a groove (62) into which a portion of the sleeve insert is swaged to secure it tightly into the tip.
Patent DE-3786013-T2 (DE)
Inventor: TSUTSUI TOSHIYUKI
IPC: C08F4/642
Filed: 1987-09-24
Granted: 1993-09-02
Abstract: Olefins is polymerisation process utilises a catalyst comprising (A) a solid catalyst component contg. transition metal (gp. (IVB) periodic table) cpds. carried on an inorganic carrier, (B) aluminoxane, (C) an organo-aluminium cpd. contg. hydrocarbon gps. excluding n-alkyl gps. The transition metal is pref. of Ti, Zr or Hf, esp. of formula R1kR2lR3mR4nMe (I) where R1 is a cycloalkadienyl gp., R2, R3 and R4 are the same or different and can be cycloalkadienyl, aryl, alkyl, aralkyl, cycloalkyl, halogen atom, H, ORa, SRb, or NRc2; Ra, Rb and Rc are independently alkyl, cycloalkyl, aryl, aralkyl or organosilyl; Me is Zr, Ti or Hf; k is 1, 2, 3 or 4; l, m, n are independently 0, 1, 2 or 3 and k+l+m+n=4. The aluminoxane is pref. of formula (II) or (III). where R is hydrocarbyl gp; X is halogen; a and b are each 0-80, but not both zero.
Patent DE-3789696-T2 (DE)
Inventor: ANDERSON J EDWARD
IPC: B61L25/00
Filed: 1987-02-10
Granted: 1994-08-11
Abstract: A method and apparatus for controlling movement of a vehicle through a network is disclosed. The network has a plurality of stations interconnected by a plurality of path segments. A plurality of branch points connect the path segments and require a vehicle approaching a branch point to be directed in either a first or second direction. Line-defining parameters are provided for each of the branch points and define a network-dividing line which divides the plurality of stations into a first set which are attainable by a vehicle being directed in a first direction and a second set attainable by a vehicle being directed in a second direction. Coordinates of a destination station are associated with a vehicle. As the vehicle approaches a branch point, the coordinates of the destination station are compared to the line-defining parameters of the approaching branch point and the destination station is determined to be in either the first set or the second set. The vehicle is directed in a first direction if the destination station is determined to be in the first set and in a second direction if the station is determined to be in a second set.
Patent DE-3850322-T2 (DE)
Inventor: TRINE JOHN A
IPC: H04R25/00
Filed: 1988-08-26
Granted: 1994-10-13
Abstract: A control switch and potentiometer assembly for use in an in-the-canal type hearing aid comprising a miniature single pole, single or double throw, push-pull control switch and rotary potentiometer. The components of the control switch and potentiometer are mounted within a durable thermoplastic resin housing which is anchored within the hearing aid. A single control knob for actuation of the control switch and potentiometer is raised and shaped to permit gripping between the fingertips of the user for removing the hearing aid from the ear canal. The switch contacts and switch wiper are designed such that the process of pulling on the potentiometer control knob to remove the hearing aid will extend the control switch, thereby disengaging a normally closed switch contact and opening a battery powered circuit so as to turn the hearing aid off. A contact leg portion of a switch wiper has a projecting corner which slidingly engages a ramp section on one of the switch contacts, thereby providing an adjustable spring force which resists moving the potentiometer control knob between the extended and retracted positions.
Patent DE-3877266-T2 (DE)
Inventor: HOUGHTON FRED
IPC: B01D3/14
Filed: 1988-06-17
Granted: 1993-04-29
Abstract: A rectifier column (10) for a vapour generator means of a heat transfer system having a reflux inlet (12) and modulating means (11, 13, 14, 15, 16) at said inlet responsive to a condition representative of the quality of the vapour being generated so as to control the flow of reflux into the column thereby maintaining optimum vapour generation. In one arrangement the modulating means comprises a temperature sensitive actuator (15), e.g. a wax filled bellows (16) which is situated in the path of the generated vapour at the output of the column.
Patent DE-3878089-T2 (DE)
Inventor: DUCKWORTH RALPH MARSLAND
IPC: A61K8/00
Filed: 1988-08-19
Granted: 1993-07-01
Abstract: The invention relates to a toothpaste containing a therapeutic agent through the use of which there is produced a sustained and enhanced level of the therapeutic agent in the oral fluids. The toothpaste comprises 30 to 75% by weight of an abrasive cleaning agent consisting at least in part of calcium carbonate, a therapeutic agent, 0.01 to 0.6% by weight of a flavouring agent, and 0.002 to 0.1% by weight of sodium saccharinate or the equivalent amount of another sweetening agent.
Patent DE-3880496-T2 (DE)
Inventor: CORDER F
IPC: E05B47/06
Filed: 1988-08-05
Granted: 1993-08-05
Abstract: A lock assembly (21) including a movable bolt (28), a movable handle (23) coupled to move the bolt (28) to an open position and a locking assembly (29) mounted for movement between a locked position securing the bolt (28) against movement and an unlocked position releasing the bolt (28) is disclosed. The locking assembly (29) moves in response to movement of the handle (23) and is normally supported in an unlocked position. Movement of the lock assembly (29) by the handle (23) results in moving to a locked position prior to movement of the bolt (28) to an opened position. An electromagnet (31) responsive to an input signal is provided to hold the locking means (29) in the unlocked position and to prevent movement of the locking means (29) to the locked position upon movement of the handle (23). This holding of the locking assembly (29) in the unlocked position permits opening of the bolt (28). Any movement without energization of the solenoid (37, 38) produces immediate locking of the bolt (28) by locking assembly (29), while movement after energization of the electromagnet (31) holds the locking assembly (29) in an unlocked position.
Patent DE-3889433-T2 (DE)
Inventor: O'CONNOR MARY ELLEN
IPC: D06F58/30
Filed: 1988-12-05
Granted: 1994-10-06
Abstract: The invention features a sanitization method and apparatus utilizing multiple microwave sources. Bacteria are killed by the combination of microwave heated water vapor and the microwave field effect. Articles such as moist fabrics, that are contained within a substantially sealed chamber, can be sanitized and dried by this method.
Patent DE-3889969-T2 (DE)
Inventor: MERCHANT DONALD K
IPC: H01H73/30
Filed: 1988-03-30
Granted: 1995-01-19
Abstract: An improved thermal circuit breaker is disclosed, featuring a U-shaped bimetallic element which latches an escapement locking arm which holds a spring biased moving contact against a fixed contact when the breaker is in the contacts closed position. The improved thermal element has terminal portions which are of lesser electrical resistivity than are other portions of the element. The relative orientation of the metals of the bimetallic element in the terminal portions are reversed with respect to their orientation in the remainder of the bimetallic element. In this way ambient temperature compensation is provided to the breaker such that the current rating of a given breaker does not vary with variation in ambient temperature.
Patent TR-199800738-T2 (TR)
Inventor: WARNER R JAY
IPC: B01J38/00
Filed: 1996-10-16
Abstract: Rodyum ve alkali metal bilesenleri içeren düsük su oranli karbonilasyon katalizör solüsyonlarinin metalik korozyon ürünlerinin ayrilmasi için bir islem açiklanmaktadir. Bu islem katalizör solüsyonunu tercihen lityum formunda bir iyon degisim reçinesiyle ve korozyon metal ürünlerinin ayrimini en iyi hale getirmek için alkali metal iyonlarinin konsantrasyonlarini düsürmeye yetecek miktarda suyla temas ettirmeyi içerir.
Patent TR-199802044-T2 (TR)
Inventor: RIECHERS HARTMUT
IPC: A61K31/53
Filed: 1997-04-04
Abstract: Bulus, Formül (I)'in karbon asidi türevleri, ki burada artiklar tarifte belirtilen anlamlara sahiptir, bu bilesiklerin üretilmesi ve bunlarin tibbi ecza olarak kullanilmalari hakkindadir.
Patent TR-199802322-T2 (TR)
Inventor: VRIES SAPE CORNELIS DE
IPC: C12N5/10
Filed: 1997-05-13
Abstract: Elimizdeki bulus, digerlerinin arasinda, su asamalari içeren apomiktik tohumlarin üretimi için bir yöntemdir. (i) bir hücrede veya zarindaki varligi aktif bir yapida olan bir proteini sifreleyen bir nükleotid sirali bitki maddesini dönüstürme, adi geçen hücre embriyojenigini aktif kilar. (ii) bu sekilde dönüsmüs maddeyi bitkilerde veya karpel içeren kisimlarinda yeniden canlandirma  (iii) embriyokesesinin etrafindaki sirayi ifade etme  Protein tercihen ligand baglayici etki alaninin çikarildigi veya fonksiyonel olarak hareketsiz kilindigi dereceye kadar degistirilmis bir leusin tekrari zengin alici enzimi olabilir.
Patent TR-199902162-T2 (TR)
Inventor: HALL DAVID C
IPC: H04M1/656
Filed: 1998-02-24
Abstract: Bir seyyar telefon bir alici, bir verici, bir mikro-islemci ve bu islemciye birlesik bir bellege sahiptir. Bellek, bir ilk-giren-ilk-çikar (FIFO) kuyrugu ve bir statik geçici bellege sahiptir. Seyyar telefon tarafindan tasinan bir ses sinyali sayisallastirilmakta ve mikro-islemciye temin edilmektedir. Sonuçtaki dijital sinyal FIFO kuyruguna sürekli olarak yazilmaktadir. Seyyar telefon kullanicisindan gelen bir birinci komuta karsilik olarak, mikro-islemci FIFO kuyrugunun içeriklerinin statik geçici bellege aktarilmasina neden olmaktadir. Kullanicidan gelen ikinci komut üzerine, geçici bellegin içerikleri bir analog sinyale dönüstürülmekte ve seyyar telefonun hoparlörü üzerinden izlenebilmektedir.
Patent TR-199903261-T2 (TR)
Inventor: CARPINO PHILIP ALBERT
IPC: C07K5/023
Filed: 1998-06-05
Abstract: Bu icat büyüme hormonu salgilanmasina neden olan ve bu nedenle endojen büyüme hormonu seviyesinin yükseltilmesi için yararli olan 2-amino-N- [1-(2,4-difloro-benzoksimetil) -2-okso-2-[3-okso-3a-piridin-2-ilmetil -2-(2,2,2-trifloroetil) -2,3,3a,4,6,7 -heksahidropirazolo[4,3-c] piridin-5-il]-etil] -2-metil-propionamid'in (L)-tartarik asit tuzu ile ilgilidir. Bir baska açidan bakildiginda, icat söz konusu bilesigin sentezlenmesinde yararli olan belirli ara maddeleri saglar. Bu icadin bilesiginin (L)-tartarik asit tuzu osteoporozis'in (kemik erimesi), insulin direnci ve büyüme hormonu eksikliginden kaynaklanan diger durumlarin ya da hastaliklarin tedavisinde veya önlenmesinde faydalidir. Mevcut icadin bilesiginin (L)-tartarik asit tuzu; bir biyofosfat bilesigi ile, esterojen ile, Premarin ile ve istege bagli olarak progesteron ile, bir esterojen agonisti ya da antagonisti ile ya da kalsitonin ile birlikte kullanildigi zaman osteoporozis'in (kemik erimesi) tedavisinde de yararlidir.
Patent DE-60000480-T2 (DE)
Inventor: LUSTIG RAYMOND
IPC: C08G63/85
Filed: 2000-03-16
Granted: 2003-04-30
Abstract: A process which can be used in oligomerization, polymerization, or depolymerization such as, for example, the production of a polyester is provided. The process comprises contacting a carbonyl compound, in the presence of a composition, with an alcohol. The catalyst comprises a catalyst having the formula of MxTi(III)Ti(IV)yO(x+3+4y)/2 wherein M is an alkali metal, Ti(III) is titanium in the +3 oxidation state, Ti(IV) is titanium in the +4 oxidation state, x and y are numbers greater than or equal to zero wherein if x equals zero, y is a number less than +E,fra 1/2+EE .
Patent DE-60002758-T2 (DE)
Inventor: TEHAN A
IPC: H05K7/20
Filed: 2000-12-11
Granted: 2004-04-08
Abstract: An integrated thermal management system for electronic devices includes a printed wiring board for supporting electronic devices, at least one die-up and one die-down electronic device, a frame and a heat sink. The board includes at least one thermally conductive layer, to which the die-down device is thermally connected. The frame member, which includes at least a first heat sink mounting location, is connected to one of the first and second surfaces of the board, adjacent to the edge. The heat sink itself, which is cantilevered over the die-up electronic device from at least one heat sink mounting location, includes a portion which is adapted to engage the die-up electrical device, a portion connected to the frame member to provide a conductive path from the die-up device to the frame member, and a convective cooling portion. The thermal management structure also includes a cold wall, which engages the frame to provide a thermally conductive connection between the frame member and the cold wall. The heat sink(s) covers only the die-up electronic device(s) and those portions of the board surface(s) between the die-up electronic device(s) and the frame necessary to thermally connect the die-up electronic device(s) to the frame, to thereby provide access to the board surfaces for inspection or testing without removal of the heat sink(s).
Patent DE-60003926-T2 (DE)
Inventor: WEIER XU
IPC: A47L9/24
Filed: 2000-11-29
Granted: 2004-06-03
Abstract: A telescopic dust collecting pipe for vacuum cleaner comprising an outer pipe and an inner pipe slidingly arranged in the outer pipe, said outer pipe being connectable with the inner pipe by a locking device; said locking device consisting of an oriented locking mechanism and a locking element, being furthermore characterised in that the oriented locking mechanism consists of an element relatively fixed to the inner pipe and of a moving element axially movable relative to the fixed element, oriented grooves being arranged axially at least on the same sides of said fixed element and moving element correspondingly to form inner and outer double layer oriented groove structures, said moving element being connected to an operating device, said operating device bringing the moving element to move axially in such a way that the inner oriented groove coincides or staggers with said outer oriented grooves; said locking element being pressed towards said groove from a side face by an elastic element, when inner oriented groove coincides with outer oriented groove, whereby said locking element can enter into the coinciding grooves lock inner pipe and outer pipe relatively; when moving element moves axially to stagger inner layer oriented groove with outer layer oriented groove, locking element is pushed out by groove wall of inner layer oriented groove, locking condition between inner pipe and outer pipe is released.
Patent DE-60005367-T2 (DE)
Inventor: DOKTER HENDRIK
IPC: C08K3/36
Filed: 2000-07-19
Granted: 2004-06-24
Abstract: The invention relates to a process to make precipitated silica, the precipitated silica so obtained, and the use of this silica as a filler material in elastomers. The process involves the steps of: charging a reactor with an aqueous medium; heating the reactor contents to 60-90  DEG C; dosing water glass (SiO2/Na2O weight ratio about 3.3, containing 15-25 % w/w of SiO2) at a rate of 60-80 g/min; dosing sulfuric acid (15-25 % w/w) simultaneously with the water glass, so that the pH during the precipitation of the silica is from 8-10. On conclusion of the dosing, allowing the reaction mixture to after-react at said pH for 3-45 minutes. Subsequently dosing sulfuric acid in 5-20 minutes, so that the pH is lowered to 6-8. Dosing water glass at about the same rate as before for about 20-60 minutes. Simultaneously dosing sulfuric acid to ensure that the pH is kept constant at 6-8. When the water glass dosing is stopped, continuing to dose sulfuric acid for 10-30 minutes, so that the pH is lowered to 3-5.5. Removing the precipitated silica from the reactor, washing it in a conventional way, drying it in a conventional way, optionally compacting it and packing it. The resulting precipitated silica is characterized by DBP oil absorption of 140-230 ml/100g, a BET surface area of 100-220 m<2>/g, a CTAB surface area of 100-200 m<2>/g, and a Hg-intrusion peak maximum of 0.065 to 0.095 ml/(g•nm).
Patent DE-60011049-T2 (DE)
Inventor: POLONKA JACK
IPC: C09C3/06
Filed: 2000-01-15
Granted: 2004-09-16
Abstract: A metallic effect pigment including a metallic, corrosion resistant reflective core of reflectivity from 40 % to 80 %; having deposited thereupon at least one dielectric coating layer formed of at least one metal oxide, the metal oxide layer having been formed by deposition on the core by hydrolysis of a hydrolyzable metal salt in a strongly acidic aqueous medium, and thereafter full transformation into the oxide by calcination.