baber/WOPTO huggingface dataset:
Patent NZ-532884-A (NZ)
Title: 1,2,4-thiadiazol-2-ium derivatives as melanocortin receptor modulators
Inventor: EISINGER MAGDALENA
IPC: A61P17/00
Filed: 2002-11-05
Abstract: 1,2,4-thiadiazol-2-ium derivatives of the formula (I) and pharmaceutically acceptable salts thereof that are suitable for use as agonists or antagonists of the melanocortin receptor are disclosed, wherein: R1 is aryl and the aryl is substituted with one or more substituents independently selected from halogen, hydroxy, alkyl, alkoxy, halogenated alkyl, halogenated alkoxy, amino, alkylamino and di(alkyl)amino; R2 is aryl and the aryl is substituted with one or more substituents independently selected from halogen, hydroxy, alkyl, alkoxy, trihalomethyl, trihalomethoxy, amino, alkylamino and di(alkyl)amino; R3 is hydrogen; R4 is aryl and the aryl is optionally substituted with one or more substituents independently selected from halogen, hydroxy, alkyl, alkoxy, halogenated alkyl, halogenated alkoxy, amino, alkylamino and di(alkyl)amino; and X¯ is selected from the group consisting of bromide, chloride, iodide, acetate, benzoate, citrate, lactate, malate, nitrate, phosphate, di phosphate, succinate, sulfate, tartrate and tosylate. More particularly, these 1,2,4-thiadiazol-2-ium derivative compounds are useful for the treatment of metabolic, CNS and dermatological disorders that are mediated by a melanocortin receptor.
Patent NZ-533739-A (NZ)
Title: Lubricating oil compositions for internal combustion engines with improved wear performance
Inventor: DECKMAN DOUGLAS EDWARD
IPC: C10M135/18
Filed: 2003-01-31
Abstract: Disclosed herein is a lubricating oil composition comprising an oil of lubricating viscosity; 0.05 to 5 weight percent of an organo molybdenum compound; and 0.1 to 12 weight percent of a borated polyisobutenyl mono- and bis-succinimide wherein the polyisobutenyl group has a molecular weight (Mn) from 500 to 2300.
Patent NZ-538953-A (NZ)
Title: Low protein cream cheese
Inventor: LAYE ISABELLE M
IPC: A23L29/206
Filed: 2005-03-21
Abstract: A low protein cream cheese composition comprising: a) about 33 - 44% fat; b) about 50 - 55% moisture; c) less than 6.5% protein; and d) about 0.1 - 0.9% of a stabilizer composition comprising a first stabilizer of carob gum at about 0.15 - 0.35% and the second stabilizer of xanthan gum at about 0.06 - 0.15%. Also disclosed is a method of making the low protein cream cheese.
Patent NZ-539672-A (NZ)
Title: Sustained release L-arginine-formulations and methods of manufacture and use
Inventor: RON EYAL S
IPC: A61K31/198
Filed: 2003-10-24
Abstract: A method for making a sustained release composition of L-arginine. The composition can be used in a pharmaceutical composition with HMG-CoA reductase inhibitor. Also disclosed is the use of the composition in a food bar for treating a vascular disease or disorder, lowering cholesterol and increasing vasodilation. Other uses of the composition are also disclosed.
Patent NZ-540373-A (NZ)
Title: Substituted 6-(2-Halogenphenyl)-triazolopyrimidines derivatives and their use as fungicide
Inventor: TORMO I BLASCO JORDI
IPC: C07C69/65
Filed: 2003-11-04
Abstract: Substituted 6-(2-halogenphenyl)-triazolopyrimidines of formula (I), processes for their preparation, their intermediates, fungicidal compositions containing them and their use for combating phytopathogenic fungi are disclosed, wherein R1 denote C1-C10-alkyl, C2-C10-alkenyl, C2-C10-alkynyl, C4-C10-alkadienyl or C2-C10-haloalkenyl and R2 is hydrogen; or R1 & R2 together with the nitrogen atom form a 5- or 6- membered heterocyclic ring; and the other variables shown in formula (I) are as defined in the specification. .
Patent NZ-541076-A (NZ)
Title: Improvements to a table
Inventor: PRENDERGAST MICHAEL
IPC: A47B3/00
Filed: 2005-07-01
Abstract: A table including a table top, the table top supported by a frame the table top having first and second opposing edges and opposing ends joining the edges, the opposing edges are angularly offset with respect to each other, the supporting frame has one or a of legs depending down from the table top, with a surface contact means in the form of a base stop, castor or roller provided at the free end of each leg, adjustment means positioned to allow the height of the table top to which the legs are connected, to be adjusted with respect to the floor wherein the adjustment means are provided intermediate the surface contact means and the free end of each leg, the table movable between a storage position and an in-use position and, in the in use position, the table top is held in a substantially horizontal plane and in the storage position in a substantially vertical plane lying adjacent to a longitudinal edge of the table support frame and wherein, the adjustment means comprise a threaded stem which is attached to either of the free end of the table leg or the surface contact means, and a threaded port into which the threaded stern can be selectively threaded and can be used for adjustment when the table is in the in-use or storage conditions.
Patent NZ-543974-A (NZ)
Title: Propionamide derivatives useful as androgen receptor modulators
Inventor: RATILAINEN JARI
IPC: C07C/
Filed: 2004-06-24
Abstract: Disclosed is a compound of formula (I) wherein X is O or NH; R2 is nitro, cyano or halogen; A is a group selected from formula (i) or (ii); and wherein the rest of the substituents are disclosed within the specification and wherein each aryl or ring residue defined above may be substituted; or a pharmaceutically acceptable salt or ester thereof. Also disclosed is the use of the above compound in the manufacture of a medicament for the treatment or prevention of androgen deficiency.
Patent NZ-547625-A (NZ)
Title: Method for producing (3-oxo-2,3-dihydro-1H-isoindol-1-yl)acetylguanidine derivatives
Inventor: SCHUBERT GERRIT
IPC: C07D209/46
Filed: 2004-11-19
Abstract: Disclosed are methods for producing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives of formula (I) using 3-hydroxy-2,3-dihydro-1H-isoindol-1-one derivatives or 3-(2-carbamoyl-phenyl) acrylic acid ester derivatives as intermediates, a method for the resolution of racemates and intermediates for use therein.
Patent NZ-548659-A (NZ)
Title: Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
Inventor: PALLADINO MICHAEL A
IPC: A61K31/496
Filed: 2005-02-04
Abstract: Disclosed is the use of dehydrophenylahistins and analogs thereof having the structure depicted, wherein the substituents are as defined in the specification, for treating a condition associated with or which relies on vascularization, that is not cancer, by reducing vascular proliferation or reducing vascular density.
Patent NZ-551605-A (NZ)
Title: Crystalline forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride
Inventor: FISCHER ANDREAS
IPC: A61K31/137
Filed: 2005-06-27
Abstract: Disclosed is a crystalline form of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, with an X-ray diffraction pattern as described in the specification. Also disclosed is a process for preparing this crystalline form. Also disclosed is the use of the crystalline form for treating pain or urinary incontinence.
Patent NZ-552646-A (NZ)
Title: Method and device for the transfer of heat from a heat source to a thermodynamic cycle with a working medium of at least two substances with non-isothermal evaporation and condensation
Inventor: BLONN JANN
IPC: F01K25/06
Filed: 2005-07-28
Abstract: Heat from a high temperature heat source 2 is transferred to a thermodynamic cycle 9 where the thermodynamic cycle 9 has a working medium composed of at least two substances with non-isothermal evaporation and condensation characteristics and the temperature of the high temperature heat source 2 is more than the decomposition temperature of the working medium of the thermodynamic cycle 9. Heat from the high temperature heat source 2 is transferred to an intermediate hot liquid cycle 4 through a first heat exchanger 3. The temperature of the working medium in the hot liquid cycle 4 is at about the boiling temperature of the working medium in the thermodynamic cycle 9. Heat is then transferred from the hot liquid cycle 4 to the thermodynamic cycle 9 through a second heat exchanger 5.
Patent NZ-552755-A (NZ)
Title: Substituted triazines as prion protein ligands and their use to detect or remove prions
Inventor: PEARSON JAMES CHRISTOPHER
IPC: C07B61/00
Filed: 2005-07-25
Abstract: Disclosed is a triazine of formula (I) as defined in the specification. Also disclosed is the use of diazine and triazine compounds as defined in the specification for the affinity binding of a prion protein and uses thereof in the detection of prion protein and treatment of prion protein associated diseases.
Patent NZ-553063-A (NZ)
Title: Capsule for preparing and delivering a drink by injecting a pressurized fluid into the capsule
Inventor: DENISART JEAN LUC
IPC: B65D81/00
Filed: 2005-08-22
Abstract: A capsule for delivering a drink, a system for producing and delivering a plurality of drinks, and a method of manufacturing a capsule for delivering a drink is disclosed. The capsule for delivering a drink by injecting pressurized fluid into the capsule comprises: a hollow body and an impermeable injection wall attached to the body, which is adapted to be punctured by an injection means foreign to the capsule; a chamber containing a bed of at least one food substance to be extracted; and means for retaining the internal pressure in the chamber. The capsule also comprises means configured to break the jet of fluid so as to reduce the speed of the jet of fluid injected into the capsule and distribute the fluid across the bed of substance at a reduced speed. An injection space between the injection wall and the chamber allows the injection means to inject at least one jet of pressurized fluid through the injection wall where the distributing and jet-breaking means comprise at least one perforated wall which separates the injection space from the chamber containing the bed of substance. The perforated wall is positioned in order to keep the bed of substance in compression in the non-hydrated state of the substance.
Patent NZ-553865-A (NZ)
Title: Humidifier including a device for regulating the degree of humidification of the air flow
Inventor: NADJAFIZADEH HOSSEIN
IPC: A61M16/16
Filed: 2005-09-15
Abstract: Apparatus for supplying a mask (7) through which air flows with a regulated degree of humidification is provided. The method of using the apparatus comprises providing a water reservoir (4) configured such that the air circulates in contact with the surface of water within the reservoir is charged with humidity; providing a heating device (3) for heating the water in the reservoir by circulating an electric current; measuring an average intensity (Iav) of the current passing through the heating device; and controlling of said average intensity (Iav) relative to a reference value. A rectification device with a blocking device is used to rectify line voltage for current control.
Patent NZ-566448-A (NZ)
Title: Conversion of plastics to hydrocarbon-based materials
Inventor: LER MICHAEL QUN
IPC: B29B17/00
Filed: 2008-09-04
Abstract: Disclosed is a method of converting a feedstock such as plastic into hydrocarbon-based materials, including the steps of: a) mixing liquid with the feedstock in a mixing chamber to form a feedstock/liquid mixture, b) heating the feedstock/liquid mixture in the mixing chamber to produce a free-flowing mixture, and c) heating the free-flowing mixture under vacuum conditions in a reaction chamber to produce a first hydrocarbon-based product in the form of a vapour; and a second hydrocarbon-based product in the form of a solid/liquid residue, characterised in that the temperature in step c) is kept below 280 degrees C.
Patent NZ-570205-A (NZ)
Title: Twin roll casting machine with reduced thrust forces on the casting moulds
Inventor: NAKAYAMA KATSUMI
IPC: B22D11/06
Filed: 2007-01-25
Abstract: Disclosed is a twin roll casting machine which has reduced forces required on casting moulds to urge them together. The machine comprises: a pair of water-cooled casting rolls laterally positioned to form a nip there between, the casting rolls biased towards each other; spindles (37) transmitting rotary movement from a drive mechanism to the casting rolls; biasing units (41) capable of supporting the spindles; bearings (39) capable of supporting the spindles; and guides (43) capable of guiding the bearings in a generally horizontal direction. The biasing units are capable of supporting the spindles such that the mass of the spindles is not carried by the casting rolls, as well as supporting the bearings. In a second embodiment the biasing unit supports cooling water supply hoses.
Patent NZ-573563-A (NZ)
Title: Calicheamicin derivative-carrier conjugates with reduced low conjugated fraction (LCF)
Inventor: KUNZ ARTHUR
IPC: A61K47/48
Filed: 2003-05-02
Abstract: Disclosed is a method for preparing a composition comprising monomeric calicheamicin derivative/antibody conjugates with reduced low conjugated fraction (LCF) having the formula, Pr(-X-S-S-W)m wherein: Pr is an antibody, X is a hydrolyzable linker that is capable of releasing the calicheamicin from the conjugate after binding and entry into target cells, W is a calicheamicin; m is the average loading for a purified conjugation product such that the calicheamicin constitutes 4-10% of the conjugate by weight; and (-X-S-S-W)m is a calicheamicin derivative, said method comprising the steps of: (1) adding the calicheamicin derivative to the antibody wherein the calicheamicin derivative is 4.5 - 11% by weight of the antibody; (2) incubating the calicheamicin derivative and an antibody in a non-nucleophilic, protein-compatible, buffered solution having a pH in the range from about 7 to 9 to produce a composition comprising a monomeric calicheamicin derivative/antibody conjugate, wherein the solution further comprises (a) an organic cosolvent, and (b) an additive comprising at least one C6-C18 carboxylic acid or its salt, and wherein the incubation is conducted at a temperature ranging from about 30 degrees C to about 35 degrees C for a period of time ranging from about 15 minutes to 24 hours; and (3) subjecting the composition produced in step (2) to a chromatographic separation process to separate monomeric calicheamicin derivative/antibody conjugates with a loading in the range of 4 - 10 % by weight calicheamicin and with low conjugated fraction (LCF) below J0 percent from unconjugated antibody, calicheamicin derivative, and aggregated conjugates.
Patent NZ-579723-A (NZ)
Title: 4-[2-(4-methylphenylsulfanyl-phenyl] piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of ADHD and other disorders
Inventor: MILLER SILKE
IPC: A61K31/451
Filed: 2008-03-14
Abstract: Disclosed is the use of 4-[2-(4-methy1phenylsulfanyl)phenyl]piperidine (the pictured compound) or an acid addition salt thereof to treat ADHD, melancholia, treatment resistant depression, or residual symptoms in depression.
Patent NZ-580804-A (NZ)
Title: Novel pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative
Inventor: KOSITPRAPA UNCHALEE
IPC: A61K31/425
Filed: 2004-02-12
Abstract: Disclosed is a pharmaceutical dosage form comprising: (A) a controlled release osmotic tablet core comprising metformin hydrochloride that exhibits the following dissolution profile when tested in a USP Type 2 apparatus at 75 rpms in 900 ml of simulated intestinal with a pH of7.5 and at 37 degrees C: 0-25 wt% of the metformin hydrochloride is released after 2 hours; 10-45 wt% of the metformin hydrochloride is released after 4 hours; 30-90 wt% of the metformin hydrochloride is released after 8 hours; not less than 50 wt% of the metformin hydrochloride is released after 12 hours; not less than 60 wt% of the metformin hydrochloride is released after 16 hours; and not less than 70 wt% of the metformin hydrochloride is released after 20 hours; and (B) an immediate release pioglitazone hydrochloride layer surrounding the osmotic tablet that releases not less than 90 wt% of the pioglitazone hydrochloride from the dosage form within 30 minutes when tested according to the United States Pharmacopeia (USP) 26, with Apparatus 1 at 100 rpm, 37degrees C and 900 ml of 0.3 M KCI-HCl Buffer, pH 2.0 and the dosage form contains not more than 0.25 wt% of the following compounds: (i) (+/-)-5-[p-[2-(5-ethyl-2-pyridyl)ethoxy]benzyl]-5-hydroxy-2,4-thiazolidinedione; (ii)(z)-5-[p-[2-(5-ethyl-2-pyridyl)ethoxy]benzylidene]-2,4-thiazolidinedione; (iii)(+/-)-5-[p-[2-(5-ethyl-2-pyridyl)ethoxy]benzyl]-3-[2-(5-ethyl-2-pyridyl)ethyl]-2,4-thiazolidinedione; (iv)(+/-)-ethyl-2-carbamoyltio-3-[4-[2-(5-ethyl-2-pyridyl)ethoxy]phenyl-]propionate; and (v) ethyl-3-p-[2-(5-ethyl-2-pyridyI)ethoxy]phenyI-propionate. (62) Divided Out of 545653
Patent NZ-582915-A (NZ)
Title: Injection device with locking mechanism for syringe carrier with the needle shield movable within the cap
Inventor: JENNINGS DOUGLAS IVAN
IPC: A61M5/20
Filed: 2008-07-28
Abstract: An injection device (110) is disclosed comprising a housing (112) adapted to receive a syringe (114) having a discharge nozzle (118). The syringe (114) is movable along a longitudinal axis of the housing (112) between a retracted position in which the discharge nozzle (118) is contained within the housing (112) and an extended position in which the discharge nozzle (118) extends from the housing (112) through an exit aperture. A syringe carrier (128) is adapted to support the syringe (114) as it is advanced. A cap (111) is removably located over the exit aperture and a needle shield (123) is located over the discharge nozzle (118). The needle shield (123) is connected to and moveable within the cap (111) in a linear direction towards the exit aperture to release the needle shield (123) from the discharge nozzle (118). The cap (111) comprises a locking component (170) which is adapted to prevent movement of the syringe carrier (128) towards the exit aperture when the cap (111) is located on the housing (112) during removal of the needle shield (123) from the discharge nozzle (118). A method of removing the cap (111) from the device (110) is also disclosed in which the needle shield (123) is removed from the discharge nozzle (118) by rotating the cap (111) relative to the housing (112).
Patent NZ-582967-A (NZ)
Title: Carton, typically for securing within crate with post, having overlapping panels with tabs pairs that inter-engage at ends with shoulder parts of adjacent tabs
Inventor: HETTINGER PETER
IPC: B65D71/18
Filed: 2010-01-28
Abstract: A carton for packaging one or more article has overlapping panels such that tab pairs of one panel struck from apertures in the panel inter-engage at their ends with shoulder portions of tabs struck from apertures of the other panel so as to secure the carton together.
Patent NZ-591099-A (NZ)
Title: Use of bacterial beta-lactamase for in vitro diagnostics and in vivo imaging, diagnostics and therapeutics
Inventor: CIRILLO JEFFREY D
IPC: C12Q1/25
Filed: 2009-08-06
Abstract: Abstract - 591099 Disclosed are fluorogenic substrates for a Mycobacterial beta-Iactamase, wherein the fluorogenic substrate is selected from CNIR5 (as shown for instance in the attached drawing), CNIR5-QSY22, CNIR7, CNIR7-TAT, CNIR9, or CNIR10 (wherein the structures of the compounds CNIR5, CNIR5-QSY22, CNIR7, CNIR7-TAT, CNIR9 and CNIR10 are all as defined herein). Further disclosed is a method for detecting a pathogenic bacteria in real time, comprising: contacting a biological sample in vitro with a fluorogenic substrate for a beta-lactamase of a pathogenic Mycobacteria (such as Mycobacterium tuberculosis); imaging the sample for a fluorescent product from beta-Iactamase activity on the substrate; and acquiring fluorescent signals at a wavelength emitted by the beta-Iactamase fluorescent product; thereby detecting the pathogenic bacteria in the biological sample; wherein the fluorogenic substrate has a chemical structure that is CNIR5, CNIR5-QSY22, CNIR7, CNIR7-TAT, CNIR9 or CNIR10. Also disclosed is a method for detecting a pathogenic Mycobacteria in a subject, comprising: contacting a biological sample in vitro with a fluorogenic substrate for a betalactamase of the pathogenic Mycobacteria (as defined above); imaging the biological sample for a fluorescent product of beta-Iactamase activity on the substrate; imaging a control sample containing the fluorogenic substrate; measuring in real time intensity of a fluorescent signal acquired at a wavelength emitted by the fluorescent product of beta-Iactamase activity on the fluorogenic substrate in the biological sample and in the control sample; and comparing the measured signal intensities, wherein an increase in the fluorescent signal intensity compared to the measured control signal correlates to a presence of the pathogenic Mycobacteria in the biological sample, thereby detecting the pathogenic Mycobacteria in the subject.
Patent NZ-592121-A (NZ)
Title: Co-processing diesel fuel with vegetable oil to generate a low cloud point hybrid diesel biofuel
Inventor: MILLER STEPHEN JOSEPH
IPC: C10G67/02
Filed: 2009-09-29
Abstract: Disclosed is a method comprising the steps of: a) combining vegetable oil with diesel to form a first mixture, wherein the vegetable oil comprises not more than 10 weight percent of said first mixture; b) hydrotreating the first mixture in a first stage to yield a hydrotreated second mixture comprising deoxygenated triglyceride components;c) isomerizing the hydrotreated second mixture in a separate second stage in the presence of an isomerization catalyst to yield a third mixture comprising hybrid diesel fuel, wherein H2S and NH3 in the second mixture have not been removedprior to isomerizing the second mixture in the second stage, and wherein effluent from the first stage goes to the second stage; and d) isolating the hybrid diesel fuel of the third mixture to yield a hybrid diesel fuel product.
Patent NZ-594145-A (NZ)
Title: Process for preparing chocolate crumb
Inventor: GODFREY GRAHAM
IPC: A23G1/56
Filed: 2010-02-03
Abstract: Disclosed is a process for preparing chocolate crumb comprising: a) providing a milk and sugar mixture or mixing together milk and sugar so as to form a mixture having total solids present in the range of 81 per cent to 88 per cent of the mixture; b) adding cocoa mass/liquor to the mixture; c) subjecting the mixture to conditions effective to bring about sugar crystallisation in the mixture; and d) drying the mixture so as to form chocolate crumb, wherein at least steps (a) to (c) are undertaken in a single reaction vessel.
Patent NZ-594282-A (NZ)
Title: Machine operating with capsules including lever to push capsule into inner compartment and locking assembly
Inventor: GIUA ALBERTO FEDERICO
IPC: A47J31/38
Filed: 2009-12-29
Abstract: A machine operating with capsules for the preparation of coffee and other hot beverages is designed to be equipped selectively with a first motorized actuator module, which comprises a support and a first electro-mechanical locking assembly mounted on the support so as to form a preassembled interchangeable module, and with a second manually operated actuator module (70), which comprises a second mechanical locking assembly (72) able to be releasably connected to a lever (5) which can be operated by a user so as to be manually actuated by means of the lever. The mechanical locking assembly comprises a toggle mechanism (73) configured to connect the lever to a thrust member (12) and move the thrust member in a substantially straight sliding direction (S). The toggle mechanism comprises at least one tie-bar (74), an arm (75) and a rod (76); the tie-bar being hinged with the thrust member and with an articulation (80); the arm being hinged with the articulation and with the machine; the rod being hinged with the articulation and with the lever.