Patent SG-11201804993R-A (SG)
Title: Selective glucagon receptor agonists comprising a chelating moiety for imaging purposes
Inventor: HAACK TORSTEN
IPC: C07K14/575
Filed: 2016-12-12
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 22 June 2017 (22.06.2017) WIPO I PCT (10) International Publication Number WO 2017/102613 Al 1111111111111101110101011111010111110 01011010111111110111011111111111110111111 (51) International Patent Classification: A61K 38/22 (2006.01) CO7K 14/575 (2006.01) A61K 38/26 (2006.01) C07K 14/605 (2006.01) (21) International Application Number: PCT/EP2016/080553 (22) International Filing Date: 12 December 2016 (12.12.2016) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 15307000.8 14 December 2015 (14.12.2015) EP (71) Applicant: SANOFI [FR/FR]; 54 me La Boetie, 75008 Paris (FR). (72) Inventors: HAACK, Torsten; c/o Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main (DE). PLETTENBURG, Oliver; c/o Sanofi-Aventis Deutsch- land GmbH, 65926 Frankfurt am Main (DE). EVERS, An- dreas; c/o Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt am Main (DE). WAGNER, Michael; c/o Sanofi- Aventis Deutschland GmbH, 65926 Frankfurt am Main (DE). BOSSART, Martin; c/o Sanofi-Aventis Deutsch- land GmbH, 65926 Frankfurt am Main (DE). BETRAND, Romain; c/o Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt (DE). (74) Agent: ESSLER, Frank; K703, c/o Sanofi-Aventis Deutschland GmbH, Global Intellectual Property Depart- ment, 65926 Frankfurt (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) W O 20 17 / 10 26 13 Al (54) Title: SELECTIVE GLUCAGON RECEPTOR AGONISTS COMPRISING A CHELATING MOIETY FOR IMAGING PUR- POSES (57) : The present invention relates to exendin-4 peptide analogues which selectively bind and activate the glucagon recept- or and comprise a chelating moiety capable of binding a metal ion and their use, for example in PET imaging.