Patent SG-11202000073X-A (SG)
Title: Anti-cd8 antibodies and uses thereof
Inventor: GIURLEO JASON T
IPC: G01N33/53
Filed: 2018-07-23
Abstract: International Patent Classification: A61K 49/00 (2006.01) C07K 16/28 (2006.01) A61K 49/16 (2006.01) GO1N 33/53 (2006.01) A61K 51/10 (2006.01) A61K 39/00 (2006.01) (21) International Application Number: PCT/US2018/043343 C Human CDS+ T-cells Cynomolgus Monkey T-cells Ir a rnAtil -0- H4sH Isotype -12 -11 -.10 Concentration of Antibody Log (M) 3 -12 -11 -10 -- -8 Concentration of Antibody Log (M) rriAla1 mAbl, EC5O 3,694e-010 EC50 3.287e-010 rnAbl H4sH Isotype (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) vitivio VIII oviolo v1111111111 Ho Eno En Hs (19) World Intellectual Property Organization International Bureau (10) International Publication Number WO 2019/023148 Al (43) International Publication Date 31 January 2019 (31.01.2019) WIPO I PCT er Road, Tarrytown, New York 10591 (US). THURSTON, Gavin; c/o Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591 (US). (74) Agent: CROWLEY-WEBER, Cara L.; FisherBroyles, LLP, 26844 E. Quarto Pl., Aurora, Colorado 80016 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (22) International Filing Date: 23 July 2018 (23.07.2018) English English (25) Filing Language: (26) Publication Language: (30) Priority Data: 62/536,239 24 July 2017 (24.07.2017) US 62/660,902 20 April 2018 (20.04.2018) US (71) Applicant: REGENERON PHARMACEUTICALS, INC. [US/US]; 777 Old Saw Mill River Road, Tarrytown, New York 10591 (US). (72) Inventors: GIURLEO, Jason T.; c/o Regeneron Pharma- ceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591 (US). MA, Dangshe; c/o Regeneron Phar- maceuticals, Inc., 777 Old Saw Mill River Road, Tarrytown, New York 10591 (US). OLSON, William; c/o Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill River Road, Tar- rytown, New York 10591 (US). TAVARE, Richard; c/o Regeneron Pharmaceuticals, Inc., 777 Old Saw Mill Riv- (54) Title: ANTI-CD8 ANTIBODIES AND USES THEREOF Figure 1 (57) : Anti-CD8 antibodies, radiolabeled anti-CD8 antibodies, fluorescently labeled anti-CD8 antibodies and their use in imaging are provided herein. Included are methods of detecting the presence of CD8 proteins in a subject or sample. [Continued on next page] WO 2019/023148 Al MIDEDIMOHNORMIE111101110M11111111111101111111111111111111 Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))