Patent SG-11201808628P-A (SG)
Title: Array-based peptide libraries for therapeutic antibody characterization
Inventor: GREVING MATTHEW
IPC: G01N33/68
Filed: 2017-03-31
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111111111 0111010101111101111111101111111111111101111111111111111111111111110111111 International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ..... .....!;,' WO 2017/173365 Al 5 October 2017 (05.10.2017) IN I PO I P CT (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, G01N 33/543 (2006.01) C40B 50/14 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, G01N 33/68 (2006.01) C4OB 50/18 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, C4OB 40/10 (2006.01) CO8F 118/02 (2006.01) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, C4OB 30/04 (2006.01) HO1J 49/16 (2006.01) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (21) International Application Number: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, PCT/US2017/025546 RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (22) International Filing Date: TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, 31 March 2017 (31.03.2017) ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (26) Publication Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (30) Priority Data: TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 62/317,353 1 April 2016 (01.04.2016) US TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 62/472,504 16 March 2017 (16.03.2017) US DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (71) Applicant: HEALTHTELL INC. [US/US]; 2420 Camino SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Ramon, Suite 125, San Ramon, California 94583 (US). GW, KM, ML, MR, NE, SN, TD, TG). (72) Inventors: GREYING, Matthew; 8829 S. 51st Street, #1, Declarations under Rule 4.17: Phoenix, Arizona 85044 (US). SMITH, David; 10485 N. — as to applicant's entitlement to apply for and be a granted 97th Place, Scottsdale, Arizona 85258 (US). SAINI, patent (Rule 4. / 7(H)) Gaurav; 900 N. Rural Road, Apt. 1093, Chandler, Arizona — 85226 (US). as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) (74) Agents: BONNEFOUS, Celine et al.; WILSON SONSINI GOODRICH & ROSATI, 650 Page Mill Road, Palo Alto, Published: California 94304 (US). — with international search report (Art. 21(3)) Designated States indicated, (81) (unless otherwise for every kind of national protection available): AE, AG, AL, AM, [Continued on next page] = (54) Title: ARRAY-BASED PEPTIDE LIBRARIES FOR THERAPEUTIC ANTIBODY CHARACTERIZATION Mask 1 Mask 2 Mask 3 ,0 %Iw,, N A ''4 , % •V *•h • : % • „ „ w‘ : %% % •,N • • • , :„„::4h.N: •: ,-, Feature Overlap: 1 &2 2&3 1 &2&3 kr) M IN FIG. 6 IN 1-1 IN 1-1 (57) : Provided herein are methods, chemical library and simulation system for performing in situ patterned chemistry. 0 Methods, systems and assays comprising the use of the synthesized chemical libraries, which increase explored protein space in a \" knowledge-based manner, are also provided for characterizing antibody-target interactions including: identifying target proteins of C antibodies, characterizing antibody-binding regions in target proteins, identifying linear and structural epitopes in target proteins, and determining the propensity of antibody binding to target proteins. WO 2017/173365 Al MIDEDIMOHNOIIMME301011111110iMEHEVOIMIE — before the expiration of the time limit for amending the claims and amendments (Rule to be republished 48.2(h)) in the event of receipt of