baber/WOPTO huggingface dataset:
Patent PT-548448-E (PT)
Inventor: OSHLACK BENJAMIN
IPC: A61K31/52
Filed: 1992-04-15
Abstract: A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of ethylcellulose is obtained by overcoating a substrate including a therapeutically active with an aqueous dispersion of ethylcellulose and then curing the coated substrate at a temperature and relative humidity elevated to a suitable level above ambient conditions until the coated dosage form attains a stabilized dissolution profile substantially unaffected by exposure to storage conditions of elevated temperature and/or elevated relative humidity. <IMAGE>
Patent PT-652768-E (PT)
Inventor: HELLSTRAND KRISTOFFER
IPC: A61K31/415
Filed: 1993-06-03
Abstract: PCT No. PCT/SE93/00496 Sec. 371 Date May 8, 1995 Sec. 102(e) Date May 8, 1995 PCT Filed Jun. 3, 1993 PCT Pub. No. WO93/24144 PCT Pub. Date Dec. 9, 1993Pharmaceutical preparation or system for activation of natural killer cells (NK cells), for example in order to treat tumors or virus infections, and which comprises a first composition containing interferon- alpha  or analogues thereof, together with a second composition containing at least one substance with H2, or 5-HT1A, receptor agonist activity, for example, histamine or serotonin. The first and second compositions are either mixed in a preparation or furnished in separate doses.
Patent PT-777513-E (PT)
Inventor: MAGGIORE ALBERT P
IPC: A63C17/00
Filed: 1995-08-14
Abstract: An in-line roller skate for use by children has a stability enhancing mechanism and a movement limiting mechanism. The stability enhancing mechanism includes two rollers, mounted on an axle, that are selectively positionable side-by-side in a normal mode or spaced apart in a stable mode. A combine arm having two fingers pivots downward to cam the rollers inward from the stable to the normal mode. Alternately, a separator arm pivots downward to slide the two rollers apart on the axle from the normal mode to the stable mode. The movement limiting mechanism includes a roller, mounted on an axle, that has teeth formed on the radially inner surface of the cylindrical outer portion. A pawl has a pawl arm extending into the inner cylindrical portion of the roller to engage the teeth and a pawl tongue that extends into a pawl adjuster. The pawl adjuster has a retaining slot and is slidably positioned in a well in the front chassis of the skate to cam the pawl up into a nonengaging position, corresponding to the free wheeling mode. The pawl adjuster can also be positioned to allow the pawl to ride on the teeth of the roller, corresponding to the forward only mode, or to restrain the pawl in the engaging position, corresponding to the full stop mode.
Patent PT-765818-E (PT)
Inventor: PINCHEN STEPHEN PAUL
IPC: C09J7/35
Filed: 1996-09-24
Abstract: Hermetically sealed packages for food, cigarettes and the like are formed from packaging material (37) having a tear tape (33) attached thereto. The tear tape includes a surface formed of a material (7) which flows under the conditions needed to seal portions (8,9) of the packaging material together when closing the package so as to fill any gaps between the tape and the packaging material portions. <IMAGE>
Patent PT-813736-E (PT)
Inventor: ADOUL JEAN-PIERRE
IPC: G10L19/12
Filed: 1996-03-05
Abstract: A codebook is searched in view of encoding a sound signal. This codebook consists of a set of codevectors each of 40 positions and comprising N non-zero-amplitude pulses assignable to predetermined valid positions. To reduce the search complexity, a depth-first search is used which involves a tree structure with levels ordered from 1 through M. A path-building operation takes place at each level whereby a candidate path from the previous level is extended by choosing a predetermined number of new pulses and selecting valid positions for said new pulses in accordance with a given pulse-order rule and a given selection criterion. A path originated at the first level and extended by the path-building operations of subsequent levels determines the respective positions of the N non-zero-amplitude pulse of a candidate codevector. Use of a signal-based pulse-position likelihood estimate during the first few levels enable initial pulse-screening to start the search on favorable conditions. A selection criterion based on maximizing a ratio is used to assess the progress and to choose the best one among competing candidate codevectors.
Patent PT-1112413-E (PT)
Inventor: MILLER GARY
IPC: E02F3/36
Filed: 1999-07-01
Abstract: A coupler for connecting a dipper arm of an excavator to a bucket without the need for the operator of the excavator to leave the cab of the excavator, the coupler having means for connecting it to the end of the dipper arm, and means, including a latching hook for connecting it to one of a plurality of different buckets and wherein locking means is provided to prevent inadvertent unlatching of the latching hook, said locking means being operable from the cab. The locking means may be gravity operated and include resiliently deformable means thereon to prevent unlatching when the coupler is inverted. Alternatively, it may be spring operated in which case, further means is provided to move the locking means against the bias of the spring. Preferably, the hook has a special internal profile so that when it is supporting the weight of a bucket, it will tend to move to a latching position, not to an unlatching position.
Patent PT-1093495-E (PT)
Inventor: LEIDNER JACOB
IPC: B43K19/02
Filed: 1999-06-22
Abstract: Disclosed is an erasable colored pencil lead composition comprising, in an embodiment, a colorant, one or more binder resins, an antioxidant, a fibrillatable or fibrillated material, and a filler. Also disclosed is a colored pencil lead composition which produces marks on paper, which are easily erased by ordinary pencil eraser. The mark made using the composition has a cohesive nature that assists in the removal from paper in sheet or film like sections by the use of an ordinary pencil eraser without smearing or leaving a residue. In a preferred embodiment, the composition is free or substantially free of low melting waxes or waxy materials. The colored pencil lead composition may further include a lubricant. Also disclosed is a method for using a colored pencil lead composition.
Patent SG-52591-G (SG)
Title: A friction pivot joint for a window stay
IPC: E05D7/00
Filed: 1991-07-09
Abstract: A friction pivot joint between two components such as two arms, or an arm and a frame or sash plate, of a window stay, said joint comprising an aperture in a first of the components, an annular shoulder surrounding and projecting from the periphery of said aperture, an aperture in said second component whereby said second component is located about said shoulder, a bushing of a self-lubricating and wear-resistant material interposed between said shoulder and said second component to prevent direct contact therebetween, and a fixing means for fixing the joint and applying friction creating pressure thereto extending through the joint and fixed within or beneath said shoulder or in said aperture.
Patent IE-36117-L (IE)
Title: Bromination of penicillin-1-oxides
IPC: C07D499/68
Filed: 1972-02-23
Abstract: 1385472 6-α-Bromoarylacetamido penicillin 1-oxides GLAXO LABORATORIES Ltd 15 Feb 1972 [24 Feb 1971 22 Nov 1971] 5375/71 and 54170/71 Heading C2C 6-α-Bromoarylacetamido penicillin 1-oxides, preferably compounds of general formula wherein R<SP>1</SP> is aryl and R<SP>2</SP> is hydrogen or a carboxyl group other than acyloxymethyl are prepared by brominating a 6-arylacetamido penicillin 1-oxide with a free radical brominating agent. Suitable free radical brominating agents include bromine, an N-bromoamide, an N-bromoimide and 1,3,5-tribromo-1,2,4-triazole and bromination may be initiated by azobisisobutyronitrile or a peroxide. Other means of initiating bromination include irradiation by ultraviolet, visible light or γ-rays. The bromopenicillins may be subjected to a ring enlargement reaction whereby a 3-methylcephem compound is formed. The bromine atom of the cephem or penicillin compounds may be replaced by other nucleophiles. Ampillin and cephalexin may be prepared from the bromo-penicillins and bromocephalosporins respectively.
[GB1385472A]
Patent IE-810293-L (IE)
Title: Diffusion of substances between two fluids via semipermeable¹membranes
IPC: A61M1/00
Filed: 1981-12-13
Abstract: A device for the diffusion of substances between fluids through semi-permeable membranes is disclosed. The device includes a stack of longitudinally extending spacer plates alternating between the folds of a folded semi-permeable membrane in which channels extend longitudinally across the face of the spacer plates, and the spacer plates also include ducts extending transversely through the stack at each end thereof, each being in fluid communication with one of the longitudinally extending sides of the spacer plates, and including a fluid connector extending between the transverse ducts at a location displaced from that longitudinally extending side and the longitudinal channels on the spacer plates.
[CA1160963A]
Patent IE-820355-L (IE)
Title: Azaprostacyclins
IPC: C07D407/12
Filed: 1982-02-22
Abstract: Azaprostacyclins of Formula I    <IMAGE>  (I)  wherein R1 is hydrogen, alkyl, cycloalkyl, aryl, a heterocyclic residue, or a phenacyl residue optionally substituted on the phenyl ring by bromine, phenyl, alkoxy, or dialkoxy, W is a free or functionally modified carbonyl group or a   <IMAGE>   wherein R8 is hydrogen or alkyl of 1-5 carbon atoms and R9 is hydrogen or a readily cleavable ether or acyl residue and wherein the OR9-group can be in the  alpha - or  beta -position, R2 is a free or functionally modified hydroxy group, R3 and R4 each independently is hydrogen, alkyl of 1-5 carbon atoms, or fluorine, D is alkylene of 1-2 carbon atoms which can be substituted by alkyl groups of 1-5 carbon atoms, R5 is hydrogen or alkyl of 1-2 carbon atoms or, when D is alkylene of 1 or 2 carbon atoms, R5, together with R6, represents a bond, R6 and R7 each independently is hydrogen or alkyl of 1-2 carbon atoms, wherein R6(R7) is halogen when R7(R6), respectively, is alkyl of 1-2 carbon atoms or R5 and R7 each independently is hydrogen or alkyl of 1-2 carbon atoms when D and R6 together form a carbocyclic ring closed via (CH2)1-3 with D as -CH< and R6 as -CH2-, and, when R1 is hydrogen, the physiologically compatible salts thereof with bases, have valuable pharmacological properties, e.g., blood-pressure-lowering and bronchodilatory activities.
Patent IE-880583-L (IE)
Title: Phenyl carbamate
IPC: A61K31/325
Filed: 1988-03-02
Abstract: The (S)-N-ethyl-3-[(1-dimethylamino)ethyl]-N-methyl-phenylncarbamate in free base or acid addition salt form is useful as pharmaceutical, particularly for systemic transdermal administration.
[US5602176A]
Patent IE-820825-L (IE)
Title: Granular detergent composition.
IPC: C11D3/395
Filed: 1982-04-07
Abstract: Granular detergent compositions comprising organic surfactant, phosphate detergency builder wherein at least 6% of the builder consists of a mixture of water-soluble orthophosphate and pyrophosphate salts, organic peroxy-acid bleach precursor and specified polymeric polycarboxylic acids or salts thereof. The compositions provide improved low temperature cleaning together with excellent soil deposition and whiteness maintenance performance.
Patent IE-33175-L (IE)
Title: Sulphonamides.
IPC: A61K31/505
Filed: 1969-06-25
Abstract: 1,268,835. Anti-diabetic sulpha-pyrimidines. SCHERING A.G. 16 June, 1969 [27 June, 1968], No. 30406/69. Heading A5B. [Also in Division C2] Pharmaceutical preparations having antidiabetic action contain as active ingredient compounds I (including salts with bases thereof) wherein R 1 and R 2 are H, halogen or C, to 4 alkyl, alkoxy or alkylmercapto, R 3 is alkyl or cycloalkyl with up to 8 carbons which may be interrupted by at least one oxygen or is alkoxy or cycloalkoxy with up to 8 carbons in which the alkyl or cycloalkyl fragment thereof may be interrupted by at least one oxygen, R 4 is H or C 1 to 4 alkyl, X signifies O, S or NH, Y is C 1 to 4 alkylene and n is 0 to 1 to 4. Bases, e.g. butyl biguanide, for salt formation may also possess a blood sugar-lowering action. Administration may be in the form of tablets, dragees, capsules, pills, suspensions or solutions.
[GB1268835A]
Patent IE-42591-L (IE)
Title: Hydraulic controller.
IPC: B62D5/097
Filed: 1976-05-05
Abstract: Apparatus for use in a vehicle having a hydraulically actuated steering mechanism and a hydraulically actuated implement. The apparatus comprises a housing, which includes a fluid inlet port, first and second working ports, for connection with the steering mechanism, a fluid return port and an auxiliary port for connection with the implement. A metering mechanism is located in the housing, and a first valve is movably located within said housing. The first valve has a neutral position communicating the inlet with said auxiliary port and blocking the inlet from said first and second working ports. The valve also has first and second actuated positions communicating said inlet port with said metering unit and communicating flow from the metering unit to said first or second working ports respectively. The valve further has surfaces blocking communication with the first and second working ports progressively restricting communication from the inlet to the auxiliary port and progressively increasing communication between the inlet and the first and second working ports as the valve is moved from said neutral position. The apparatus further includes a control valve for directing fluid to the implement when said first valve blocks flow of fluid to the auxiliary port.
[US3996838A]
Patent FI-812437-L (FI)
Inventor: MARQUETTE GEORGES HENRI ALBERT
IPC: C08B31/00
Filed: 1981-08-06
Abstract: A preferably continuous process for gelatinising and chemically modifying starch comprises; providing an aqueous slurry of starch and gelatinising the starch therein; mixing the starch with a reagent therefor and subjecting the mixture, during or after gelatinisation, to ultra-high frequency radiation (preferably 2450 MH2) to chemically modify the starch. The starch may be subjected to the radiation, e.g. under the conditions of gelatinisation or after application of a starch glue to a paper sheet.
Patent FI-852656-L (FI)
Inventor: VIOLANTE MICHAEL R
IPC: A61K9/16
Filed: 1985-07-04
Abstract: The invention relates to a method for producing uniformly sized particles of water-insoluble pharmaceutical preparations or other organic compounds. A suitable, solid, organic compound is first dissolved in an organic solvent and the solution may be diluted with a non- solvent. An aqueous, precipitating liquid is then introduced, non-aggregated particles being precipitated with a uniform mean diameter. The particles are then separated from the organic solvent. Parameters such as temperature, the ratio of non-solvent to organic solvent, the rate of introduction, the agitation speed and the volume can be varied depending on the organic compound and the required particle size. <IMAGE>
Patent IE-811086-L (IE)
Title: Fixing element
IPC: F16B13/04
Filed: 1981-05-15
Abstract: An axially elongated fastening element is made up of an anchor bolt and a spreader wedge each having a wedge surface. Initially the two parts are inserted in the unspread condition into a borehole. By providing relative movement in the axial direction between the wedge surfaces, the fastening element is anchored in the borehole. The wedge surfaces are divided into at least two portions each disposed at a different angle relative to the axis of the fastening element. The initial spreading action is effected when the portion of the wedge surfaces having smaller angles slide relative to one another.
Patent IE-43038-L (IE)
Title: Butter like food product
IPC: A23D7/02
Filed: 1976-07-29
Abstract: A process for the production of an edible product of the butter or margarine type, which comprises thoroughly mixing a medium containing fats and an aqueous medium having a viscosity of from 2000 to 20,000 centipoises, as measured at a temperature between 20 DEG C and 30 DEG C, at a temperature in the range from about 15 DEG to 45 DEG C, resulting directly in the formation of an emulsion of the water-in-oil type which represents the edible product of the butter or margarine type.
[US4112132A]
Patent IE-791733-L (IE)
Title: Calf milk replacer
IPC: A23K10/28
Filed: 1979-09-12
Abstract: Milk containing animal feed compositions, and aqueous feeds containing them, are stabilised by the presence of a complex salt consisting of ammonium, alkali metal or alkaline earth metal ions and formic acid in which the ratio of acid to ions is from 2:1 to 4:1. Preferred complex salts are those commonly known as ammonium tetraformate and potassium diformate. The milk containing compositions can contain 0.10 to 5, preferably 0.5 to 2% wt. of complex salts, corresponding figures for the aqueous feeds being 0.01 to 0.5, preferably 0.05 to 0.2% wt. The complex salts can be added as solids, when appropriate, or as an aqueous solution or distributed on a comminuted solid carrier (e.g. finely divided silica).
Patent IE-881762-L (IE)
Title: Process for preparing sertraline intermediates
IPC: C07C49/697
Filed: 1988-06-10
Abstract: A novel three-step process for preparing 4-(3,4-dichlorophenyl)-4-phenylbutanoic acid is disclosed, which involves (1) reducing 4-(3,4-dichlorophenyl)-4-ketobutanoic acid to 4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid; (2) then converting the intermediate hydroxy acid formed in the first step to 5-(3,4-dichlorophenyl)-dihydro-2(3H)-furanone, and (3) thereafter reacting the resulting gamma-butyrolactone compound with benzene in a Friedel-Crafts type reaction to form the desired final product. The latter compound is known to be useful as an intermediate leading to 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone and ultimately, to cis-(1S)(4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrah ydro-1-naphthaleneamine (sertraline), which is known to be a preferred anti-depressant agent in the field of medicinal chemistry. The aforementioned 5-(3,4-dichlorophenyl)-dihydro-2(3H)-furanone and 4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid are both novel compounds. There is also disclosed a novel process for converting 5-(3,4-dichlorophenyl)-dihydro-2(3H)-furanone directly to 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone, as well as an alternate novel process for converting 4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid directly to this same key intermediate.
Patent IE-45590-L (IE)
Title: Anilines.
IPC: C07C309/66
Filed: 1977-09-16
Abstract: Pesticidal Compositions Compounds of the formula I < IMG > ( I) wherein R1 represents C1-C4 alkyl, C1-C4 alkoxy or halogen, R2 represents hydrogen, C1-C3 alkyl, C1-C4 alkoxy or halogen, R3 represents hydrogen, C1-C3 alkyl or halogen, and R4 represents hydrogen or methyl, with the proviso that the total number of carbon atoms contained by the substituents R1, R2, R3 and R4 does not exceed 8, X represents < IMG > and R5 represents hydrogen or methyl and R6 represents C1-C6 alkyl which is unsubstituted or substituted by halogen or represents C2-C4 alkenyl or C3-C6 cycloalkyl or the group -N(R7)R8, in which R7 represents hydrogen or C1-C4 alkyl and R8 represents C1-C6 alkyl which is unsubstituted or substituted by halogen, which are useful in combatting microorganisms in particular phytopathogenic fungi.
[CA1199928A]
Patent IE-852103-L (IE)
Title: Preparing a vaccinal influenza virus polypeptide
IPC: C12N7/00
Filed: 1985-08-27
Abstract: Vaccinal polypeptides for protection against influenza virus infection comprising an immunogenic determinant of the HA2 subunit of an HA protein.
[EP0176493A1]
Patent IE-902120-L (IE)
Title: Process for bulk polymerisation
IPC: C08F4/42
Filed: 1990-06-12
Abstract: A process for the bulk addition polymerisation of acrylic monomer species to give a polymer, which process is carried out in an extruder and is catalysed by a catalyst comprising two components: (a) an (initiator) first component of formula (I): M(Xm)(Yn)Zp (I) wherein M is Si, Ge or Sn m and p are each an integer and n is 0 or an integer such that (m + n + p) =4; X is QR<1>R2<2> where Q is N, P, As or P(=T)G.D where T is O or S and G and D are each independently a bond, O or S and R<1> and R<2> are each independently optionally substituted hydrocarbyl or together are optionally substituted hydrocarbadiyl which are inert in the process conditions of the present invention, or, when Q is P(=T)G.D as hereinbefore defined, R<1> and R<2> are each independently M(Yn)Zp as hereinbefore defined. Y is independently any group as defined for X, or any group selected from a group OA where A is optionally substituted hydrocarbyl inert in the process conditions of the present invention, or trialkylsilylalkyl; Z is independently any group as defined for Y, or an organic polymer radical comprising further M(Yn)Zp moieties; or p is 2 and Z2 is a group Z<1>2 of the formula OSiR<5>R<6>OSiR<7>R<8>O-where R<1>, R<6>, R<7> and R<8> are each independently selected from any of the values defined for R<1> or R<2>, or Z2 is a group Z<2>@ which is a moiety -EBE- where E is a bond or O and B is a polymer diradical, or E is O and B is an inorganic solid on whose surface the two -O- groups are located, which comprises further -OMXmYnO-moieties; and (b) a (co-catalyst) second component salt comprising an anion selected from azide, cyanide, cyanate, fluoride, bifluoride, nitrate and optionally substituted organic mono- and poly-phosphonates, phosphinates -sulphonates, -sulphinates, -carboxylates, -siloxides and -oxides; and a cation which in use of the catalyst is inert under the polymerisation process conditions yet renders the co-catalyst available in the polymerising medium. i
[EP0405786A2]
Patent IE-45943-L (IE)
Title: Blender
IPC: B01F29/62
Filed: 1977-11-08
Abstract: A dual shell rotational blending apparatus which is formed by two hollow cylindrical leg sections joined at one end to form a closed apex portion. One cylindrical leg section has a mean length greater than the other leg section such that as the unit is rotated and the apex portion reaches the uppermost position, the contents therein separate in unequal portions. The separation of the contents in unequal portions forces a lateral cross flow of material as rotation continues.
[US4141657A]
Patent IE-822504-L (IE)
Title: Pyrimidine derivative.
IPC: C07D241/42
Filed: 1982-10-15
Abstract: This invention relates to the 2-isopropylamino-pyrimidine-N-oxide of the formula: <IMAGE> to a preparation process of the same consisting in submitting at 15 DEG to 45 DEG C., 2-isopropylamino pyrimidine to a smooth oxidation by stoichiometric proportions or a slight excess of up to 10% of an appropriate oxidizing agent and to a therapeutic composition of matter comprising said compound as an active ingredient therein.
[US4492701A]
Patent IE-892961-L (IE)
Title: Synthesis of intermediate useful in the preparation of¹nojirimycin and related compounds
IPC: C07H11/00
Filed: 1989-09-15
Abstract: 5-Amino-5-deoxy-1,2-O-isopropylidene- alpha -D-glucofuranose is conveniently prepared by a hydride reduction of 5-azido-5-deoxy-1,2-O-isopropylidene- alpha -D-glucuronolactone and can readily be converted to nojirimycin, deoxynojirimycin or homonojirimycin.
Patent NO-762541-L (NO)
Inventor: MURDOCH H W
IPC: F16C33/12
Filed: 1976-07-21
Abstract: BORKRONE