baber/WOPTO huggingface dataset:
Patent NZ-540092-A (NZ)
Title: Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors
Inventor: WALLACE ELI
IPC: C07D405/04
Filed: 2003-11-10
Abstract: Disclosed is a compound of formula (I) wherein: At least one of the positions 6 or 7 of the quinazoline ring must be substituted by a group A and the remaining positions are optionally substituted by up to three R2 groups; X is N, CH or a C-CN group; R1 is independently aryl or heteroaryl substituted by at least one R6 group and optionally substituted by up to three R5 groups where R5 and R6 are as described in the specification; R2 represents H, halogen, cyano, nitro, trifluoromethyl, difluoromethyl, trifluoromethoxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl, optionally substituted as defined; and A is represented by formula (II) wherein: T represents alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, or heterocyclylalkyl optionally substituted as defined; L is N or a CR4 group where R4 is as defined in the specification; Q is selected from CR3R11R12 or NR11R12 where R3 is the same as R2 above and R11 and R12 are as defined; D represents H, trifluoromethyl, difluoromethyl, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, -SO2NR9R7, -C(O)R9, -OC(O)R9 or -C(O)NR7R9 optionally substituted as defined; and The remaining substituents are as defined in the specification. Compounds of the type discloser are EGFR and ErbB2 inhibitors useful in the treatment of hyperproliferative diseases.
Patent NZ-542306-A (NZ)
Title: Antibodies against human IL-21 receptor and uses therefor
Inventor: YOUNG DEBORAH A
IPC: C12N5/09
Filed: 2004-03-12
Abstract: Disclosed are human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21 R). The antibodies can act as antagonists of IL-21 R activity. The disclosed compositions and methods are useful for treating or preventing inflammatory disorders, autoimmune diseases, allergies, transplant rejection, cancer, and other immune system disorders.
Patent NZ-543202-A (NZ)
Title: Pharmaceutical composition comprising a bispecific antibody for epcam
Inventor: KUFER PETER
IPC: C07K16/30
Filed: 2004-05-26
Abstract: Provided are bispecific single chain antibody constructs comprising at least two domains, one binding to human EpCAM antigen and the second binding to human CD3 antigen. The EpCAM binding domain contains CRD-H3 region and amino acid sequence NXD, wherein X is an aromatic amino acid. Further provided are similar constructs comprising specific amino acid sequences and vectors encoding the said bispecific single chain antibodies. Also provided is the use of the constructs in the preparation of medicaments for the treatment of tumorous disease.
Patent NZ-546333-A (NZ)
Title: A lifting assembly for a shutter to allow continuous casting
Inventor: BRAZIS PAUL
IPC: E04G17/00
Filed: 2004-10-29
Abstract: A lifting assembly which comprises a pair of support frames (10), a shutter (21) slidably engaged to and between the support frames and a hoist (15, 20) operatively connected between at least one of the support frames and the shutter to cause movement of the shutter with respect to the support frames. In use, when the support frames are fixed, operation of the hoist causes movement of the shutter, and when the shutter is fixed, operation of the hoist causes movement of the support frames. The assembly is suited to the continuous casting of a structure by the shutter as it provides means for separately and independently moving the shutter in relation to the support frame or moving the support frame in relation to a stationary shutter.
Patent NZ-546942-A (NZ)
Title: Preparation and composition of inter-alpha inhibitor proteins from human plasma for therapeutic use
Inventor: LIM YOW-PIN
IPC: A61K/
Filed: 2004-11-05
Abstract: Disclosed is a process for producing a blood plasma-derived inter-alpha inhibitor protein (IaIp) composition comprising a mixture of inter-alpha inhibitor protein (Ial) and pre-alpha protein (Pal), wherein the lal and the Pal are present in said mixture in a physiological proportion, the process comprising: isolating from blood plasma a plasma fraction containing lal and Pal, wherein the lal and Pal are present in a physiological proportion; and purifying the plasma fraction to obtain an IaIp composition with a purity of IaIp ranging from about 85% to about 100% pure; wherein the isolating is by solid phase extraction.
Patent NZ-556732-A (NZ)
Title: Pyrazine compounds for inflammation and immune-related uses
Inventor: SUN LIJUN
IPC: A61K31/4965
Filed: 2006-01-25
Abstract: Disclosed herein is a pyrazine compound of general formual (V) wherein the substituents are as defined within the specification, processes for their preparation and compositions comprising said compounds. Such compounds are useful in the manufacture of a medicament for inhibiting immune cell activation; inhibiting cytokine production in a cell; inhibiting T-cell and/or B-cell proliferation in response to an antigen; the treatment and/or prevention of immune disorders; and fur suppressing the immune system.
Patent NZ-556798-A (NZ)
Title: Vertical wheel machine and method and method for compression molding sealing liners
Inventor: MATTICE DANIEL L
IPC: B29C43/34
Filed: 2006-06-05
Abstract: An apparatus for compression molding sealing liners in premade closure shells includes a shell loader for presenting premade closure shells in sequence, a mold charge placement device (132) for placing charges of liner material into the premade shells, and a vertical wheel molding machine (30) for receiving the closure shells in sequence from the loader and compression molding the mold charges to form sealing liners within the closure shells. The vertical wheel molding machine preferably includes a wheel (32) mounted for rotation around a horizontal axis and a plurality of angularly spaced molds disposed around the wheel. Each of the molds preferably includes a first mold segment and a second mold segment disposed radially outwardly of the first mold segment. One of the first and second mold segments, preferably the second mold segment, includes a nest for receiving a premade closure shell. The other of the first and second mold segments, preferably the first mold segment, includes a core for engaging and compression molding the mold charge of liner material within the shell.
Patent NZ-562251-A (NZ)
Title: Heating a wellbore using an electrical heater and heated fluid in piping
Inventor: FOWLER THOMAS DAVID
IPC: E21B36/04
Filed: 2006-04-21
Abstract: Disclosed is an in situ conversion system for producing hydrocarbons from a subsurface formation (232). The system comprises a plurality of u-shaped wellbores in the formation; piping (220) positioned in at least two of the u-shaped well bores; a fluid system (222) coupled to the piping; and an electrical power supply. The power supply provides electrical current to at least a portion of the piping located below an overburden (234) in the formation to resistively heat at least a portion of the piping, with heat transferring from the piping to the formation. The fluid system is a fluid circulation system, and circulates hot heat transfer fluid through at least a portion of the piping to form at least one heated portion of the formation.
Patent NZ-562742-A (NZ)
Title: Paired main tee clip
Inventor: BANKSTON JOHN
IPC: B42F13/00
Filed: 2006-04-24
Abstract: A clip for accurately and quickly suspending pairs of spaced parallel grid main tees from superadjacent structural channels. The clip works with a separate drop clip that hooks over and depends from the structural channel. The paired main tee clip has a central body region configured like a conventional grid tee bulb thereby enabling the paired main tee clip to mate with the drop clip in the same way the drop clip mates with a conventional grid tee bulb thereby achieving a system that is cost-effective in manufacture and installation.
Patent NZ-563845-A (NZ)
Title: RNAi sequences against the Influenza A segment 1 PB2 gene and uses thereof as anti-viral therapeutic
Inventor: GE QING
IPC: C12N15/113
Filed: 2006-04-07
Abstract: An siRNA comprising a first nucleic acid sequence selected from SEQ ID NOs: 7 and 5503-5506 and a second nucleic acid that is at least 84% complementary to the first nucleic acid sequence, wherein the siRNA has a duplex region from 15-60 nucleotides in length. The siRNA is targeted towards the Influenza A segment 1 PB2 gene and is used as a therapeutic against Influenza respiratory infection.
Patent NZ-570530-A (NZ)
Title: Pharmaceutical compositions comprising 6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4)diazepine derivatives
Inventor: KNEGTEL RONALD
IPC: A61P11/00
Filed: 2007-02-13
Abstract: Disclosed are 6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4)diazepine derivatives as represented by the general formula I, wherein X1 is a bond, O, NR8, S, SO, or SO2; Y1 is O or NR9; R1 is H, aliphatic, cycloaliphatic, aryl, heteroaryl, or heterocyclyl, each of which may be optionally substituted; and wherein the remaining substituents are as defined herein. Also disclosed is the use of a compound as defined above, in the manufacture of a medicament for treating a proliferative disorder (such as melanoma, myeloma, leukemia, lymphoma, neuroblastoma, or a cancer selected from colon, breast, gastric, ovarian, cervical, lung, central nervous system (CNS), renal, prostate, bladder, or pancreatic), a neurodegenerative disorder, an autoimmune disorder, an inflammatory disorder, or an immunologically mediated disorder.
Patent NZ-585522-A (NZ)
Title: Post, stay, bracket and fastener for supporting wire fence with post and bracket having plural apertures for selective releasable fastening
Inventor: RICHARDSON MARK FLETCHER
IPC: E04H17/08
Filed: 2010-05-21
Abstract: Post 11 has plural apertures 111, 112, 114 and 115 along an upper portion and has a lower portion to extend below ground. Stay 12 is adapted to abut and engage post 11 at an upper end and to be inserted below ground at a lower end. Bracket 13 has a plurality of apertures and is typically inverted U-shaped and releasably couples the stay 12 to the post 13. Fastener, typically a bolt, 16 is used to selectively fasten bracket 13 to post 11.
Patent NZ-585698-A (NZ)
Title: Bacteriocins and Lactobacillis and Enterococcus strains
Inventor: STERN NORMAN J
IPC: A23K1/18
Filed: 2005-03-18
Abstract: Discloses an isolated bacteriocin peptide produced by lactic acid bacterium strain Enterococcus faecalis (deposit ID: NRRL B-30645). Further discloses the use of a lactic acid bacterial strain or bacterocin in the production of a non-human animal feed-stuff. The animal feed-stuff is designed to reduce levels of colonisation of at least one target bacteria in the animal.
Patent NZ-587032-A (NZ)
Title: Method for treating meat products with carbon monoxide and pH modifying agent
Inventor: ROTH ELDON
IPC: A23L5/41
Filed: 2005-03-02
Abstract: Disclosed is a method of treating a meat product, wherein the method including the steps of: (a) injecting a treatment mixture into an interior volume of a meat product at an injection location, the treatment mixture including carbon monoxide and an injection fluid and being injected into the volume of the meat product through an injection conduit inserted into the volume of the meat product, wherein the meat product comprises a cut of meat; and (b) injecting either: (i) a pre-treatment fluid into the volume of the meat product prior to injecting the treatment mixture, the pre-treatment fluid including a pH modifying material (such as an ammonium hydroxide solution) and being injected into the volume of the meat product through the injection conduit or an additional injection conduit inserted into the volume of the meat product; or (ii) a post-treatment fluid into the volume of the meat product after injecting the treatment mixture, the post-treatment fluid including a pH modifying material (such as an ammonium hydroxide solution) and being injected into the volume of the meat product through the injection conduit or an additional injection conduit inserted into the volume of the meat product; or (iii) a pH modifying material into the volume of the meat product simultaneously with injecting the carbon monoxide, the pH modifying material comprising an ammonia-based pH increasing material and being injected into the volume of the meat product through the injection conduit or an additional injection conduit inserted into the volume of the meat product.
Patent NZ-595424-A (NZ)
Title: Nasal assembly including gusset, nozzles and connector portions
Inventor: GUNARATNAM MICHAEL KASSIPILLAI
IPC: A61M16/06
Filed: 2004-02-20
Abstract: A nasal assembly for delivering breathable gas to a patient, comprising: a frame (216) having a main body (219) and a side frame member provided on each lateral side of the main body, each side frame member including an integrally formed first connector portion; a nozzle assembly (218) including a gusset or base portion (248) and a pair of nozzles (250), the nozzle assembly being coupled with the main body of the frame with the pair of nozzles structured to sealingly engage with nasal passages of a patient's nose in use; at least one inlet conduit structured to deliver breathable gas into the frame and nozzle assembly for breathing by the patient; a pair of second connector portions provided to a respective first connector portion of the frame, at least one of the second connector portions being in communication with the at least one inlet conduit; and a headgear assembly removably connected to at least one of the pair of second connector portions so as to maintain the frame and the nozzle assembly in a desired adjusted position on the patient's face.
Patent NZ-596225-A (NZ)
Title: Air inductor comprising an inner sleeve and an outer aleeve, where the inner sleeve is insertable into the outer sleeve from either direction
Inventor: CHALLIS RUSSELL JOHNSON
IPC: E03C1/084
Filed: 2009-12-23
Abstract: An air inductor comprises an inner sleeve having a water inlet and a water outlet, the inner sleeve being arranged to form a venturi and having a side air inlet 3, and an outer sleeve having first and second different attachment means at opposite ends for attachment to different plumbing fixtures. The inner sleeve is insertable into the outer sleeve from either end, so as to selectably locate the first and second attachment means at the water inlet and water outlet respectively and vice versa.
Patent NZ-596992-A (NZ)
Title: Il-12/p40 binding proteins
Inventor: LACY SUSAN E
IPC: A61K39/395
Filed: 2006-06-29
Abstract: 596992 Disclosed is a binding protein that possesses an antigen binding domain, said binding protein capable of binding a p40 subunit of human IL-12, said antigen binding domain possessing six CDRs: CDR-H1, CDR-H2, CDR-H3, CDR-L1, CDR-L2, and CDR-L3, wherein: CDR-H1 is: KSVMGVS, HIYWDDDKYYNPSLKS, RGIRSAMDY, KASQSVSNDVA, YASNRYT and QQDYNSPWT respectively.
Patent NZ-597453-A (NZ)
Title: Fluorinated aminotriazole derivatives as alxr agonists
Inventor: BUR DANIEL
IPC: A61P9/00
Filed: 2010-06-07
Abstract: 597453 The disclosure relates to fluorinated aminotriazole derivatives of formula (I), wherein A, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds. Compounds of the disclosure include: 5-Phenyl-oxazole-4-carboxylic acid { 2-[4-(1,1-difluoro-ethyl)-thiazol-2-ylmethyl]-2H-[1,2,3]triazol-4-yl} -amide; 2-Methyl-5-m-tolyl-oxazole-4-carboxylic acid { 2-[4-(1,1-difluoro-ethyl)-thiazol-2-ylmethyl]-2H-[1,2,3]triazol-4-yl} -amide; 5-(3,5-Difluoro-phenyl)-2-methyl-oxazole-4-carboxylic acid { 2-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-2H-[1,2,3]triazol-4-yl} -amide; 5-(3-Dimethylamino-phenyl)-oxazole-4-carboxylic acid { 2-[4-(1,1-difluoro-ethyl)-thiazol-2-ylmethyl]-2H-[1,2,3]triazol-4-yl} -amide; 5-(4-Fluoro-phenyl)-oxazole-4-carboxylic acid { 2-[4-(1,1-difluoro-ethyl)-thiazol-2-ylmethyl]-2H-[1,2,3]triazol-4-yl} -amide and 5-(3-Dimethylamino-4-fluoro-phenyl)-2-methyl-oxazole-4-carboxylic acid { 2-[4-(1,1-difluoro-ethyl)-oxazol-2-ylmethyl]-2H-[1,2,3]triazol-4-yl} -amide. Also disclosed is the use of such compounds for the treatment of inflammatory diseases, obstructive airway diseases, allergic conditions, HIV-mediated retroviral infections, cardiovascular disorders, neuroinflammation, neurological disorders, pain, prion-mediated diseases and amyloid-mediated disorders; and for the modulation of immune responses.
Patent NZ-599709-A (NZ)
Title: Curtain sided vehicles
Inventor: BUTTLER PAUL
IPC: B60J5/06
Filed: 2012-05-01
Abstract: 599709 A post 40, for an end of a curtain for a curtain sided trailer or truck, where the post 40 includes at its upper end a roller device having a carriage mounted on rolls or wheels engageable with a track from which the curtain is able to be suspended, to enable the post 40 to be pulled along the track. The post 40 has lower and upper parts of its length connected together by a coupling enabling relative movement between the parts. The lower part defines a major part of the length of the post 40 and is adapted for engagement along its length with an end margin of a side curtain to enable horizontal tensioning of this side curtain. When the roller device of the post 40 is engaged with the track, or an extension of the track, at least the lower part of the post 40 is movable between a position adjacent to the side of the body of the trailer or truck on which the track or track extension is provided, and a position spaced laterally outwardly of the side of the body of the trailer or truck.
Patent NZ-605972-A (NZ)
Title: Nucleophilic catalysts for oxime linkage
Inventor: SIEKMANN JUERGEN
IPC: A61K47/48
Filed: 2011-07-29
Abstract: Disclosed is a method of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation; said carbohydrate moiety oxidized by incubation with a buffer comprising an oxidizing agent selected from the group consisting of sodium periodate (NaIO4), lead tetra-acetate (Pb(OAc)4) and potassium perruthenate (KRuO4); wherein an oxime linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer; and wherein said oxime linkage formation is catalysed by the nucleophilic catalyst m-toluidine. Also disclosed is a method of forming a hydrazone linkage between an oxidized carbohydrate moiety on a therapeutic protein and an activated water soluble polymer containing an active hydrazide group comprising the steps of: a) oxidizing a carbohydrate moiety on a therapeutic protein by incubating said protein with an oxidizing agent selected from the group consisting of sodium periodate (NaIO4), lead tetraacetate (Pb(OAc)4) and potassium perruthenate (KRuO4); and b) forming a hydrazone linkage between the oxidized carbohydrate moiety of the therapeutic protein and the activated water soluble polymer containing an active hydrazide group in the presence of a nuclephilic catalyst under conditions allowing formation of said hydrazone linkage; wherein said water soluble polymer containing an active hydrazide group is selected from the group consisting of polyethylene glycol (PEG), branched PEG, a polymer comprising a polymethacrylate backbone with short polyethylene glycol (PEG) side chains, polysialic acid (PSA), carbohydrate, polysaccharides, pullulane, chitosan, hyaluronic acid, chondroitin sulfate, dermatan sulfate, dextran, carboxymethyl-dextran, polyalkylene oxide (PAO), polyalkylene glycol (PAG), polypropylene glycol (PPG), polyoxazoline, polyacryloylmorpholine, polyvinyl alcohol (PVA), polycarboxylate, polyvinylpyrrolidone, polyphosphazene, polyoxazoline, polyethylene-comaleic acid anhydride, polystyrene-co-maleic acid anhydride, poly(1-hydroxymethylethylene hydroxymethylformal) (PHF), and 2-methacryloyloxy-2’-ethyltrimethylammoniumphosphate (MPC); and wherein said hydrazone linkage formation is catalysed by the nucleophilic catalyst m-toluidine.
Patent NZ-615554-A (NZ)
Title: Reclosable flexible film packaging products and methods of manufacture
Inventor: LYZENGA DEBORAH A
IPC: B31B50/88
Filed: 2012-03-16
Abstract: Disclosed is a reclosable flexible film package that is made from a flexible film having a fold forming a folded edge (34), at least two opposing free edges (26,28), and at least a front panel (64) and a back panel (66), the opposing free edges being sealed together to form at least one sealed edge such that front and back panels define an interior space; a score (38) in the flexible film of the front panel forming a flap that defines an opening when moved toward the folded edge and has a separation force for the flap from the film; and a label (24) extending uninterrupted from edge to edge of the at least two opposing free edges, being attached on the film (22) by pressure sensitive adhesive, and extending beyond the score on the front panel to reseal the package opening defined by the flap, the pressure sensitive adhesive having a peel strength between the film and the label that is greater than the separation force along the score, and the label further having a tack free portion defining a pull tab (36).
Patent NZ-615624-A (NZ)
Title: Anti - sclerostin antibody crystals and formulations thereof
Inventor: CHRISTIAN TWINKLE R
IPC: C07K16/22
Filed: 2012-03-23
Abstract: Disclosed is a sterile formulation comprising a crystal of an anti-sclerostin IgG antibody, wherein at least 70% of the antibody is in a crystalline form. Also disclosed is the use of formulation comprising anti-sclerostin IgG antibody crystals for increasing bone mineral density, treating a disorder associated with decreased bone density, treating a bone-related disorder, or improving outcomes in a procedure, replacement, graft, surgery or repair in a mammalian subject.
Patent NZ-619497-A (NZ)
Title: Conditioning of biomass for improved c5/c6 sugar release prior to fermentation
Inventor: DOTTORI FRANK A
IPC: D21C1/02
Filed: 2012-07-12
Abstract: Disclosed herein is a process of conditioning biomass prior to a conventional pretreatment process for C5 and C6 sugar recovery from lignocellulosic biomass for fermentation to ethanol, the conditioning process comprising: (a) heating the biomass with steam (20) for a time period between 5 minutes to 60 minutes to achieve a steam treated biomass having a temperature of about 80 to 100°C; (b) squeezing or compressing the steam heated biomass (40) for removing a liquid stream (55) containing resins, oils, fatty acids or other inhibitors of downstream hydrolysis or fermentation; and (c) adding water, and/or a catalyst (70) to adjust the moisture content of the steam treated biomass to about 45% to 80% and prepare it for fermentation.
Patent NZ-623676-A (NZ)
Title: A layered sheet material
Inventor: HOW ANTHONY MICHAEL
IPC: E02D17/20
Filed: 2012-09-14
Abstract: A laminated sheet material [10], and a geo-container [24] produced therefrom, suitable for use in alleviating erosion. The laminated sheet material [10] is characterized in comprising at least three layers, namely an entrapment layer [12] for trapping gravel, soil, sand or the like particles; a filtration layer [16] for allowing filtration of water and other moisture through the laminated sheet material [10]; and a reinforcement layer [14] between the entrapment and filtration layers [12, 16] for reinforcing the laminated sheet material [10]; increasing inter-layer peel strength between the entrapment and filtration layers [12, 16] and reducing elongation of the laminated sheet material [10]. The laminated sheet material [10] further includes bonding means [21] for bonding the material layers together.