baber/WOPTO huggingface dataset:
Patent SG-11201900738Y-A (SG)
Title: Gpr156 variants and uses thereof
Inventor: GONZAGA-JAUREGUI CLAUDIA
IPC: C12Q1/68
Filed: 2017-07-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 February 2018 (01.02.2018) WIP0 I PCT omit VIII °nolo omolom omoi ioo Imo (10) International Publication Number WO 2018/022967 Al (51) International Patent Classification: C07K 14/705 (2006.01) C12Q 1/68 (2006.01) (21) International Application Number: PCT/US2017/044321 (22) International Filing Date: 28 July 2017 (28.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/367,973 28 July 2016 (28.07.2016) US (71) Applicant: REGENERON PHARMACEUTICALS, INC. [US/US]; 777 Old Saw Mill River Road, Tarrytown, New York 10591-6707 (US). (72) Inventor: GONZAGA-JAUREGUI, Claudia; 777 Old Saw Mill River Road, Tarrytown, New York 10591-6707 (US). (74) Agent: LEGAARD, Paul K.; Stradley Ronon Stevens & Young, LLP, 30 Valley Stream Parkway, Malvern, Penn- sylvania 19355 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) 1-1 N (54) Title: GPR156 VARIANTS AND USES THEREOF N (57) : The disclosure provides nucleic acids, including cDNA, comprising alterations that encode aspartic acid at a position el corresponding to position 533 of the hu man G protein- coupled receptor 156 protein (GPR156). The disclosure also provides isolated and recombinant human GPR156 protein variants that comprise an aspartic acid at a position corresponding to position 533. The change to aspartic acid, and the gene encoding this change, associate with unipolar depression. The disclosure also provides methods for 1-1 © determining whether a subject has or has a risk of developing unipolar depression, based on the identification of such alterations in f'1 the gene (DNA or RNA) encoding GPR156.
Patent SG-11201903829P-A (SG)
Title: Melatonin mini-tablets and method of manufacturing the same
Inventor: LAUDON MOSHE
IPC: A61K9/20
Filed: 2016-11-29
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111011111111101 111111111101111101011H011H111101111110111110111111111110111111 Organization 0 International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/078429 Al 03 May 2018 (03.05.2018) W I P0 I P C T (51) International Patent Classification: A61K 9/20 (2006.01) (21) International Application Number: PCT/IB2016/057190 (22) International Filing Date: 29 November 2016 (29.11.2016) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/415,014 31 October 2016 (31.10.2016) US (71) Applicant: NEURIM PHARMACEUTICALS LTD. [IL/IL]; 27 HaBarzel Street, 6971039 Tel Aviv (IL). (72) Inventors: LAUDON, Moshe; c/o Neurim Pharmaceu- ticals Ltd., 27 HaBarzel Street, 6971039 Tel Aviv (IL). ZISAPEL, Nava; c/o Neurim Pharmaceuticals Ltd., 27 HaBarzel Street, 6971039 Tel Aviv (IL). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. — = = _ = _ — = Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). = (84) = = _ = = = = = Published: = — with international search report (Art. 21(3)) Il cn ei 00 IN IN © (54) Title: MELATONIN MINI-TABLETS AND METHOD OF MANUFACTURING THE --.... SAME ,1 (57) : The instant invention is generally directed to a patient-friendly drug delivery system for targeted populations, such as 0 pediatric and geriatric patients. Specifically, the present invention relates to a pharmaceutical composition in the form of mini -tablets. \" Even more specifically, the present invention relates to a pharmaceutical composition comprising a 0 of melatonin in the form of mini-tablets. therapeutically-effective amount
Patent SG-11202000123S-A (SG)
Title: Lactobacillus plantarum cjlp475 strain having antiviral and immunomodulatory effects and composition comprising the same
Inventor: KIM MIN-JEONG
IPC: A61P31/12
Filed: 2019-07-12
Abstract: The present disclosure relates to a novel Lactobacillus plantarum CJLP475 strain having acid-resistance, bile-resistance and an immune-enhancing activity, and a composition including the same.
Patent HU-185083-B (HU)
Inventor: SKRIBEK PAL
IPC: A47J31/40
Filed: 1982-01-06
Abstract: A találmány főleg szörpautomaták számára szolgáló keverő fej, amelynek adagoló feje, központi keverő idoma, ebben elhelyezett szirüpvezetéke, a szirupvezetéket körülvevő folyadékvezetője, szabályozó szelepei, azokat működtető kezelő karja és keverő kúpja van. Jellegzetessége, hogy az adagoló fej (1) és a központi keverő idom (2) között a szirupvezeték (4) nyílásánál sziruptere (6), a folyadékvezeték (5) nyílásánál folyadéktere (7) van. A központi keverő idom (2) perdítő kamrával (10) határos, a perdítő kamra (10) a folyadéktérrel (7) perdítő csatornák (9) útján összeköttetésben van. A szabályozó szelepnek (21) rugalmas anyagú gyűrűalakú szelepteste (21b), azon belül központosán elhelyezkedő, legömbölyített felületű, pl. cseppalakú szelepzárja (21a), a szelepzárat (2la) mozgató szelepemelő karja (21c), valamint a szelep (21) zárását elősegítő szeleprugója (22) van. Nemzetközi osztályjelzet: (51) NSZO3 B 67 D 5/56 A 47 J 31/40: 31/46 F 16K 19/00  -1-
Patent IS-1688-B (IS)
Inventor: BETALOSI ENDRE P
IPC: A61K31/00
Filed: 1992-10-29
Abstract: The invention relates to 5-(2-chloro-C2-5-alkyl)-4-methyl-1,3-thiazoles of the general formula I, <CHEM>  wherein R is a straight-chain 2-chloro-C2-5-alkyl group  and a process for their preparation, which is characterized by     (A1) reacting a 3-(2-chloro-C2-5-alkyl)-3-thiocyanato-2-propanone of the general formula IV <CHEM> in an organic solvent with gaseous hydrogen chloride to obtain the corresponding 2-chloro-5-(2-chloro-C2-5-alkyl)-4-methyl-1,3-thiazole of the general formula II   <CHEM>  or   (A2) reacting a 3-(2-chloro-C2-5-alkyl)-3-thiocyanato-2-propanone of the above formula IV with an aqueous mineral acid to obtain the corresponding 5-(2-chloro-C2-5-alkyl)-2-hydroxy-4-methyl-1,3-thiazole of the general formula III <CHEM> and reacting the thus obtained compound of the formula III with a halogenating agent to obtain the corresponding 2-chloro-5-(2-chloro-C2-5-alkyl)-4-methyl-1,3-thiazole of the above formula II,  and   (B) hydrogenating the compound of the general formula II to obtain the 5-(2-chloro-C2-5-alkyl)-4-methyl-1,3-thiazole of the above general formula I.   The invention further relates to intermediates for the above process, and pharmaceutical compositions comprising the compounds of formula I.
Patent ZA-9414-B (ZA)
Title: Water-soluble addition polymers of cyclohexene anhydrides
Inventor: CREAMER MARIANNE PATRICIA
IPC: C08F2/10
Filed: 1994-01-04
Abstract: The present invention provides water-soluble polymers containing, as polymerized units: (a) from about 3 to about 95 percent by weight of one or more cyclohexene anhydrides or the alkali metal or ammonium salts thereof. The present further provides aqueous polymerization processes for making the polymers. The water-soluble polymers are useful as water-treatment additives for boiler waters and cooling towers and as detergent additives acting as builders, anti-filming agents, dispersants, sequestering agents and encrustation inhibitors.
Patent AT-409709-B (AT)
Title: Drawer guide
IPC: A47B88/04
Filed: 1999-04-19
Granted: 2002-10-25
Abstract: A drawer guide comprises a furniture rail which can be laid in bores (12, 13) of a furniture carcass wall (11) by means of pins (5, 6) (1) and at least a telescopic rail mounted displaceably relative to this furniture rail (1), supporting a telescopic furniture part, whereby the pins (5, 6) connected solidly to the furniture rail are provided in pairs and the axes of the pins (5, 6) lie in a common plane. The rear pin (5) viewed in direction of extension of the drawer guide bears toothed wheel work (9), which is provided if required only on part of the periphery of the pin (5), and the other pin (6) has a smooth surface, whereby the free end of this pin is designed as a conical lug (14) and the middle axial distance (I) of both pins (5, 6) is less or greater than the axial distance (L) of the bores (12, 13) of the furniture carcass wall (11) receiving the pins (5, 6).<IMAGE>
Patent HU-183314-B (HU)
Inventor: SZUECS LASZLO
IPC: F28F1/24
Filed: 1981-02-06
Abstract: Die Erfindung bezieht sich auf einen Waermeaustauscherbestehend aus mindestens einem Rohr und einer zieharmonikaaehnlichen gebogenen Verrippung aus waehrmeleitendem Material.Durch die Erfindung wird ein kostenguenstig herzustellender Waermeaustauscher mit wesentlich verbesserten waermetechnischen Eigenschaften vorgeschlagen, die zu einer erheblichen Reduzierung der Aufwendungen an waermetechnischen Anlagen fuehrt. Das Wesen der Erfindung besteht in einer konstruktiven Veraenderung der Verrippung, wobei mindestens einer der Rippenfluegel 4A; 4B jeder Rippe 2 Strukturen 18A; 18B; die die Kontinuitaet des Rippenfluegelmaterials unterbrechen und/oder gebogene Oberflaechen 5A; 5B aufweist, die mit einer Ebene senkrecht zur Achse 10 des Rohres 1 einen spitzen Winkel Alpha bildet.
Patent HU-181059-B (HU)
Title: Method for producing figuredly creped cotton fabric
Inventor: PERLEKY GYULA
IPC: D06Q1/02
Filed: 1980-02-22
Abstract: Crepe fabric is woven from normally twisted and overtwisted cotton yarns in selected proportion, and wetted at 60-95 DEG C temperature prior to, or after, lye printing applied during the finishing process. The fabric may be dyed with reactive, direct, or diazo dye, or colour printed prior to or after lye printing either without or after bleaching.
Patent LT-3511-B (LT)
Title: Lubricant with antifriction mineral additive
Inventor: KLICIUS JULIUS
IPC: C10M125/00
Filed: 1993-06-21
Abstract: The present invention relates to the grease production field and can be used at friction points of machines and mechanisms.The purpose of the invention is to produce grease with cheap additive from industry waste, to significantly improve the antifriction characteristics of the grease, reduce friction and extend the life of the grease and greased parts through a hard antifriction layer.The grease consists of a base, which can be any grease used in machines (solid oil, nigrosine, lubricant etc. and an additive produced from mechanically crushed magnetic serpentine mineral or magnetic serpentinite where 95% of the particles should constitute less than 10 microns. Composition of the additive (weight %):Serpentine 70-80 %Magnetite 10-15 (up to 20) %olivine, pyroxene, mica, chlorite and other minerals 0-10 %The main infrastructural feature of the mineral additive is that magnetite and serpentine particles are tightly interconnected be means of smaller grains, whereby the additive adheres to the surface of metal parts and forms a hard and very smooth antifriction layer.
Patent MT-P1064-B (MT)
Title: Method for making seals,in particular for garments and seal in accordance with said method
Inventor: TIBILETTI GIUSEPPE
IPC: G09F3/14
Filed: 1990-07-11
Abstract: Method for making seals, in particular for garments, in which there are supplied in series at intervals on an unbroken string (10) alternately bodies (11) and graft elements (12) in seats in said bodies (11) to constitute with the string (10) between them a connected plurality of seals separable by cutting the unbroken string. Said method is used advantageously to realize a separable unbroken series of seals each of which comprises a body (11) and at least one complementary graft (12) element insertable in a seat in the body (11) and connected by a section of string. To achieve this an unbroken string comprises alternately bodies (11) and graft elements (12) formed on itself at regular intervals. A specific form of embodiment calls for the alternate formation of a body (11) and two graft elements (12) turned in opposite directions so that each separate seal has a body connected by the string (10) to two graft elements therein.
Patent YU-49341-B (YU)
Inventor: JOST KLAUS
IPC: C07C263/10
Filed: 1995-11-02
Abstract: Kontinualan postupak za pripremanje izocijanata reakcijom odgovarajućih primarnih amina sa fozgenom u prisustvu nekog izocijanata, kao rastvarača, naznačen time, što se primarni amin, eventualno rastvoren u nekom inertnom, organskom rastvaraču, i fozgen, koji je rastvoren u izocijanatu u koncentraciji od 10 do 60 mas.%, računato na rastvor izocijanat/fozgen, na temperaturama od 60 do 180В°C i pritiscima od 1 do 30 bar (105 do 3x106 Pa), prevode u odgovarajući izocijanat, pri čemu molski odnos fozgena prema unetom aminu iznosi 4:1 do 1:1, i što izocijanat,upotrebijen kao rastvarač, ne sadrži čvrstu supstancu, a vrednost hlora koji može biti hidrolizovan manja je od 2%. Prijava sadrži još 3 zavisna zahteva.
Patent ZA-80441-B (ZA)
Title: New analogs of prostacyclin,intermediate products thereof,processes for their preparation and their use as medicaments
Inventor: SCHOELKENS B
IPC: A61P7/02
Filed: 1980-01-24
Abstract: What is disclosed are prostacyclin analogs of the general formula I <IMAGE>  I  which have a more specific action and/or a longer action than the naturally occurring prostacyclin PGI2, as well as intermediate products for their preparation and a process for their preparation. The compounds of formula I are distinguished by inhibitory action on thrombocyte aggregation and by relaxation of the vascular walls, in particular of the coronary arteries. They can thus be used as medicaments.
Patent ZA-91204-B (ZA)
Title: A riser and divider system for a display apparatus
Inventor: CARROLL FRANCIS ALFRED
IPC: A47B87/02
Filed: 1991-01-10
Abstract: The riser and divider system of the invention includes risers 1, dividers 2, two divider connectors 3 on each divider 2 and cross divider. Each connector 3 has a hook 5 which grips the riser 1 or other divider 2. A tongue 4 is provided on each divider 2 for the retention of the connector 3. The pinned riser fixing component 21 comprises a plug 22 having a shoulder 23 and pin 24. The shoulder 23 fits in the corresponding shaped cut-out and the pin 24 fits through poles provided in the shelf. The system also includes an end-stop 28 which is fixed to the end of each riser 1. A stabiliser component is optionally provided on a divider 2. Other components are support clips 211 and 231. The system can be used for the erection of standard riser and divider arrangements, stepped divider arrangements, binning arrangements, hopper arrangements, shelf-arrangements and various other shop display.
Patent AT-385526-B (AT)
Title: Apparatus for the production of a yarn
IPC: D01H1/11
Filed: 1985-07-01
Granted: 1988-04-11
Abstract: To produce a yarn 8, a pair of codirectionally rotating spinning drums 1, 2, between which a suction-exposed spinning gusset 5 is formed, a drawframe 3, preceding the spinning drums 1, 2, for a fibre slubbing 4 guided through the spinning gusset 5, and a drawframe 6 for the supply of sheathing fibres are provided, one delivery roller 20 of the said drawframe being arranged coaxially to one of the spinning drums 1, 2 and being suction- exposed in the region of the delivery gusset 21 of the drawframe 6. In order to ensure an improved incorporation of the sheathing fibre 7 into the drawn fibre slubbing 4, the delivery roller 20 is provided, between the suction zone 22 in the region of the delivery gusset 21 of the drawframe 6 and a suction zone 24 in the region of the fibre slubbing 4, with a blowing zone 25 which is directed towards the guide gusset between the delivery roller 20 and the opposite spinning drum 2 and which causes the stream of sheathing fibres to be fanned open. <IMAGE>
Patent AT-388636-B (AT)
Title: Sound receiver for the stereophonic transmission of sound events
Inventor: GOERIKE RUDOLF DR
IPC: H04R5/027
Filed: 1987-09-14
Granted: 1989-08-10
Abstract: In a recording device with two microphones arranged essentially in an oppositely oriented fashion, using simulations of the human head for the stereophonic recording of sound events, the microphones being incorporated into the outer auditory canal simulations, and the simulation of the human head being restricted to that of the auricular simulations with outer auditory canal and the microphones operating with unilateral directional effect, preferably with a position of the auricular openings corresponding to the human head in the low frequency range up to about 1500 Hz as directional microphones, in the frequency range above that with spectral resolution of the outer tube transfer function, it is provided that the microphones 15, 16 with unilateral directional effect are inserted into the auricular simulations 1, 2 obliquely with respect to the auricular axis, or with an oblique acoustic opening. <IMAGE>
Patent CA-1142176-B (CA)
Title: 2-azaergolines and 2-aza-8 (or 9)-ergolenes
Inventor: KORNFELD EDMUND C
IPC: A61P25/16
Filed: 1982-08-18
Granted: 1983-03-01
Abstract: ABSTRACT OF THE DISCLOSURE             Novel 2-azaergolines, 2-aza-8(or 9)-ergolenes, which are neuroleptic agents, are described herein. These compounds are prepared by reacting a 7-amino-6-ketobenzo[f]quinoline with a diazotization agent, e.g. sodium nitrite and a strong mineral acid, to yield the 6-keto-7-diazonium salt intermediate, followed by reduction to yield the final product.
Patent DK-154618-B (DK)
Inventor: MENELL HANS
IPC: B29C61/00
Filed: 1980-03-17
Abstract: 1. A method for producing endless rubber drive belts having longitudinal ribs on their inner periphery and having embedded filiform strength carriers of synthetic polymers extending at least substantially in a longitudinal direction of the belts, in which a raw belt is built up in a reverse layer sequence, formed to its final shape and vulcanized in an external mould and afterwards reversed to a condition ready for use, characterized in that the raw belt is built up with an outer diameter corresponding to the minimum inner diameter of the external mould, expanded within said mould while subjecting the strength carriers to plastic stretching, vulcanized and afterwards cooled with said strength carriers being maintained in their stretched condition.
Patent FI-66484-B (FI)
Inventor: ROLIN INGMAR
IPC: F24F11/00
Filed: 1982-02-02
Granted: 1984-06-29
Abstract: 1. Method for ventilation, particularly of large rooms, such as workshops and industrial halls, wherein the supplied air, controlled depending upon the room temperature, is supplied mainly from above downwards characterized in that the supplied air is delivered in the form of impulses and the impulse flow of the supplied air is controlled, on the basis of the temperature difference between the temperature in the upper part of the room and the temperature in the lower part of the room in such a way that if the temperature difference exceeds a predetermined value the impulse flow of the supplied air for maintaining the desired temperature distribution in the room is increased so that the projected distance of the supplied air reaches into the lower personnel area.
Patent FI-72223-B (FI)
Inventor: BORTER EPHRAIM
IPC: H01H3/12
Filed: 1982-11-02
Granted: 1986-12-31
Abstract: In the design of electrical switchboards or control panels or the like there are employed push buttons for the actuation of a switch for performing a desired control function or operation. There is disclosed a push button containing a solid or rigid front impact flange member and a rear impact cam or detent which is arranged at the tip of a tongue-like spring member or resilient tongue and possesses an inclined guide surface. The push button can be mounted in the cover plate of an assembled switchboard or control panel or the like, without the need for any auxiliary tools, and is positively self-retained thereat without there being required access to the rear side of the cover plate or to the interior of the switchboard panel. A spring-biased support member of a switch arranged rearwardly of the cover plate presses the push button at its near impact surface against the rear side or face of the cover plate and retains such in the desired rest position. The push button can be again dismantled, with the aid of extraordinarily simple means, out of a completely assembled together unit without there being necessitated any access to the rear side of the cover plate.
Patent FI-86832-B (FI)
Inventor: HINRICHSEN THOMAS
IPC: B65D75/64
Filed: 1986-12-18
Granted: 1992-07-15
Abstract: Readily peelable and sterilizable packages composed of two multi-layer sheets which are attached to one another by sealing in the zone regions and in which one sealing layer comprises an ethylene/1-butene copolymer and the other polypropylene or a propylene/ethylene copolymer.
Patent FI-82499-B (FI)
Inventor: NISKANEN TOIVO
IPC: F16K5/06
Filed: 1987-02-23
Granted: 1990-11-30
Abstract: The present invention relates to a mixing apparatus for improving the treatment of fibre suspension. The apparatus comprises a housing (13) for the fibre suspension flow having a mixing chamber with an inlet opening (14), an outlet opening (16), and a fluidizing rotor (22) arranged in the mixing chamber. The fluidizing rotor (22) is formed of a shaft (21) extending through the housing (13) substantially at a right angle to the fibre suspension flow therethrough and finger-like fluidizing members (26) attached to the end (25) of said shaft (21) in the housing (13). <IMAGE>