baber/WOPTO huggingface dataset:
Patent IL-71326-A0 (IL)
Title: Crf analogs and pharmaceutical compositions containing them
IPC: C12N15/00
Filed: 1984-03-23
Abstract: Rat Corticotropin Releasing Factor (rCRF) and the human counterpart thereof have the formula:
 H-Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-
 Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-
 Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-
 Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2.
 Analogs are disclosed that are at least as potent. One which has been found to be particularly potent is:
 H-Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-
 Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-
 Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-
 Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2.
 These analogs or pharmaceutically or veterinarily acceptable salts thereof, dispersed in a pharmaceutically or veterinarily acceptable liquid or solid carrier, can be administered to mammals, including humans, to achieve a substantial elevation of ACTH,  beta -endorphin,  beta -lipotropin, other products of the pro-opiomelanocortin gene and corticosterone levels and/or a lowering of blood pressure over an extended period of time. They may also be used as stimulants to elevate mood and improve memory and learning, as well as diagnostically. 
<??>In the analogs, one or more of the first three N-terminal residues may be deleted or may be substituted by a peptide up to 10 amino acids long and/or by an acylating agent containing up to 7 carbon atoms. A number of other substitutions may also be made throughout the chain.
Patent IL-84206-A0 (IL)
Title: Bridged bicyclic imides as anxiolytics and antidepressants
IPC: C07D403/12
Filed: 1987-10-19
Abstract: A series of bridged bicyclic imide compounds having a 4-(4-[2-pyrimidinyl]-1-piperazinyl)butyl group attached to the imide nitrogen are useful for alleviating the symptoms of anxiety and depression in human subjects.
Patent IL-87123-A0 (IL)
Title: Purification of gm-csf
IPC: C07K14/005
Filed: 1988-07-15
Abstract: A method of purifying granulocyte-macrophage colony-stimulating factor (GM-CSF), particularly recombinant human GM-CSF, in good yield and with retention of biological activity, comprising sequential anion-exchange, dye-ligand affinity, gel filtration and reversed-phase chromatography is disclosed.
Patent IL-89603-A0 (IL)
Title: Reservoir for controlled active substance delivery,apparatus containing the same and method for the manufacture and use of the apparatus
IPC: A61K9/70
Filed: 1989-03-14
Abstract: A reservoir has a release surface for controlled, diminishing release of active substances throughout the period of application to solid, liquid or gaseous acceptors. At at least one position on the reservoir (102), a flat (101) cross-sectional surface of the reservoir is smaller than the release surface. Also described are a device for controlled, diminishing release of active substances throughout the period of application having at least one reservoir (102), and the use of the device disclosed in technology, human and veterinary medicine, cosmetics and pest control, at least one active substance to be released being effective in the field of technology, human and veterinary medicine, cosmetics and pest control.
Patent FI-20011513-A0 (FI)
Inventor: LINDSTROEM JONAS
IPC: G09F15/00
Filed: 2001-07-11
Abstract: The invention relates to a stand for illuminated advertisements (1) comprising a frame part (2), at least one poster surface (3) connected to the frame part, onto which surface a poster or the like to be displayed can be placed, lighting means arranged on the inside of the frame part for illuminating the poster surface from behind, and a cover part (4), which can be placed over the poster surface and which has a transparent face (5) for displaying the poster on the poster surface. Between the cover part (4) and the poster surface (3) is arranged a mechanism (10-12) which allows the poster surface (3) to move with respect to the frame part (1), when the covert part (4) is opened, in such a way that the poster on the poster surface becomes more easily accessible to facilitate the changing of the poster, and that closing the cover part will cause the poster surface to return from the poster changing position to the poster's normal display position.
Patent FI-20021768-A0 (FI)
Inventor: ILM MYOEH
IPC: G08B26/00
Filed: 2002-10-04
Abstract: The invention relates to a signaling method for a network system. In this solution, a common analog read signal is fed via a signaling channel to all nodal units under control of a control unit. The read signal is modified by modification means units at each nodal unit for identification of the nodal unit and data indicating the state of each nodal unit is added to the read signal. In the control unit, the state of each nodal unit is determined based on the modification made and the read signal.
Patent FI-20055159-A0 (FI)
Inventor: SALONIEMI JYRKI
IPC: D21G5/00
Filed: 2005-04-08
Abstract: The wet end of the paper machine comprises at least one passage space (100) which extends from a tending side (HP) of the machine to a drive side (KP) of the machine and is closed in a machine direction, and inside which operating staff can walk in an operating situation safely and protected from ambient conditions between the tending side (HP) of the machine and the drive side (KP) of the machine.
Patent IL-100239-A0 (IL)
Title: Pharmaceutical compositions
IPC: A61K47/10
Filed: 1991-12-04
Abstract: A stable aqueous solution of human calcitonin (hCT) which remains free of hCT fibrils for at least 24 hours at 25 DEG C which comprises water, hCT and a cellulose derivative and/or an acid, the type of acid and the amount of acid being so chosen as to achieve said stability in the absence of a salt or a buffer.
Patent IL-105144-A0 (IL)
Title: Automatic injector
IPC: A61M5/20
Filed: 1993-03-24
Abstract: The invention relates to an automatic injector, in which, prior to use, different substances which are not allowed to be in contact with each other for a long period of time, can be stored separately, one of said substances being a solid and another being or comprising a solvent for this solid, which solid can be injected as an injection liquid after dissolving it in said solvent; said injector comprising a discharge mechanism (46), a cartridge assembly (25), and a front cover (30), connected to a front portion of said cartridge assembly and provided at its front with a pierceable central area (31);  said cartridge assembly comprising:   a hollow barrel (26) having a backward portion with a cylindrical inner surface and a front portion, a pierceable stopper (28) sealingly connected to the front portion of the barrel and constituting a compartment in front of said stopper for accommodating the solid, a piston (33) slidably accommodated in the backward portion of the barrel and constituting a compartment for liquid in said barrel, an injection needle (35) longitudinally extending in said liquid compartment, and a means (36) for centring the distal end of the needle in order to position the needle tip towards the pierceable stopper; said front cover being capable of rotational movement relative to the outer sleeve (20), which movement causes a backward movement of the barrel in the cartridge container (22), the piston and the needle bearing thereon remaining in their places, as a result of which the injection needle pierces the pierceable stopper and allows the liquid in the barrel to reach the solid compartment through the needle.   <IMAGE>
Patent IL-109901-A0 (IL)
Title: Peptidic phosphinyloxymethyl ketones and pharmaceutical compositions containing them
IPC: C07F9/6527
Filed: 1994-06-05
Abstract: Disclosed are compounds, compositions and methods for inhibiting interleukin - 1 beta  protease activity, the compounds having the formula (I) disclosed herein.
Patent IL-111825-A0 (IL)
Title: Poly-Beta-1->-4-n-acetylglucosamine
IPC: A61K9/20
Filed: 1994-11-30
Abstract: The present invention relates, first, to a purified, easily produced poly- beta -1->4-N-acetylglucosamine (p-GlcNAc) polysaccharide species. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a  beta -1->4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. <??>Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.
Patent IL-127582-A0 (IL)
Title: Process for producing a paraffin-based object and such an object
IPC: C11C5/00
Filed: 1997-05-24
Abstract: Preparation of perfume-containing paraffin-based articles, especially candles, comprises dissolving the perfume in an ester (especially an organic ester, e.g. triglyceride)-containing solvent and adding the solution to (or dissolving it in) the paraffin. Also claimed are: (i) perfume concentrates comprising an ester as above containing the perfume (especially an ether oil) in an amount of 1/3-2/3 of the total wt.; and (ii) high perfume-content paraffin-based articles containing a waxy material together with an ester or ester/wax acid mixture.
Patent IL-129797-A0 (IL)
Title: Rechargeable battery packs
IPC: H01M2/10
Filed: 1999-05-05
Abstract: This invention discloses an improved rechargeable battery pack (30) particularly suitable for use with cellular telephones (32) or other portable devices, wherein the battery pack (30) includes at least one rechargeable cell (40), at least one primary cell (52), and a rechargeable cell recharger (34), including a voltage converter (50), receiving an output from the at least one primary cell (52) at a first voltage and converting it to a second voltage suitable for recharging the at least one rechargeable cell (40).
Patent IL-139209-A0 (IL)
Title: Lysozyme dimers and methods utilizing the same
IPC: A61K38/00
Filed: 1999-04-15
Abstract: The present invention relates to applications of a dimerized form of lysozyme for the improvement of impaired animal or human fertility. It further relates to the prevention or treatment of reproductive disorders in animals or humans and to the use of a lysozyme dimer for the manufacture of a pharmaceutical composition suitable for such applications, as well as to an improved method for the preservation of human or animal cells, particularly germ cells, and for prolongation of eukaryotic cell life.
Patent IL-150824-A0 (IL)
Title: Screening method
IPC: C40B40/10
Filed: 2001-02-02
Abstract: The screening method for a compound or a salt thereof that alters the binding property between Neuromedin U or a salt thereof and TGR-1 or a salt thereof, characterized by using Neuromedin U, a derivative thereof or a salt thereof and TGR-1 or a salt thereof, can be useful for screening a therapeutic and/or prophylactic agent for hypertension and stress-related diseases, etc. A TGR-1 antagonist can be useful as a therapeutic and/or prophylactic agent for hypertension and stress-related diseases, etc.
Patent IL-152401-A0 (IL)
Title: New polycyclic indanylimidazoles with alpha2 adrenergic activity
IPC: A61P9/02
Filed: 2001-05-07
Abstract: A compound of formula Iwherein R1 to R3, -A-, m and t are as defined in claim 1, or a pharmaceutically acceptable salt or ester thereof, useful as an alpha2 adrenergic agent.
Patent IL-176198-A0 (IL)
Title: Discharge device with a metered dose valve
IPC: G01F11/28
Filed: 2006-06-08
Abstract: A discharge device with a metered dose valve is proposed. The metered dose valve comprises an inlet valve, a metering chamber and an outlet valve. In order to allow discharge of fluid from the metering chamber in multiple steps, a user can depress and release an actuation member multiple times in a selected discharge state wherein refill of the metering chamber with new liquid is prevented.
Patent IL-177611-A0 (IL)
Title: Anti-a?? antibody
IPC: C07K16/18
Filed: 2006-08-21
Abstract: This present invention provides a composition that is suitable for administration to a human subject comprising an anti-Abeta antibody that is free of Abeta peptide or that has acceptably low levels thereof, free of non-human Abeta peptide or that has acceptably low levels thereof, or having an undetectable concentration of Abeta peptide.
Patent IL-183340-A0 (IL)
Title: [1,2,4] triazolo[4,3-a] pyridine derivatives and pharmaceutical compositions containing them
Filed: 2007-05-21
Abstract: The invention provides novel, substituted 7-arylamino[1,2,4]triazolo[4,3-a]pyridine compounds Formula (I): pharmaceutically acceptable salts, solvates and prodrug compounds thereof, wherein W, R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>9</SUB>, R<SUB>10 </SUB>R<SUB>11</SUB>, R<SUB>12</SUB>, R<SUB>13</SUB>, R<SUB>14 </SUB>and L are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation. Also disclosed is the use of such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and pharmaceutical compositions containing such compounds.
Patent RO-126563-A0 (RO)
Title: Bioreactor for generating energy from alternative sources
Inventor: ASSMANN ALLO
IPC: C02F11/02
Filed: 2011-03-16
Abstract: The invention relates to a bioreactor for obtaining biogas. According to the invention, the bioreactor consists of a spherical enclosure (1) for fermenting a biomass, being covered with a transparent roofing (18), provided with photovoltaic cells, for using the solar energy, said enclosure being carried out of prefabricated concrete segments, being positioned on a base consisting of two joined steel layers, said enclosure consisting of some double walls between which there is an air layer (2) wherein there are positioned supporting columns or posts, the enclosure (1) being provided at the external side, at the ground level, with some circular openings (3) through which the cold air penetrates, with some circular openings (4) at the upper side, through said openings there being discharged the warm air resulting after cooling the biomass, some openings (13) for discharging the residue of the fermented material.
Patent RO-128457-A0 (RO)
Title: Disk electric current generator
Inventor: URZICA RADU
IPC: H02K1/00
Filed: 2013-02-06
Abstract: The invention relates to an electric current generator. According to the invention, the electric current generator comprises a disk (1) on which there is wound a conductor (3), so as to obtain an angle α, the disk (1) rotating together with a shaft (2) in a magnetic field generated by four pairs of N-S permanent magnets (4) located on a housing (5) at 90° from one another, in the shape of a cross, and the non-interrupted conductor (3) within the winding of the disk (1) passes through a groove cut in the shaft (2), onto the second disc making a new winding which rotates together with the second disk in a magnetic field generated by the four pairs of N-S magnets (4) mounted on the stator housing (5) of the second disk in the shape of a cross.
Patent RO-134561-A0 (RO)
Title: Triphosphonic acid product with central aromatic unit
Inventor: ARDELEANU RODINEL
IPC: C07F9/38
Filed: 2020-05-18
Abstract: The invention relates to a triphosphonic acid ligand product with a central aromatic nucleus meant to be used for obtaining products with a porous structure of metal-organic network type. According to the invention, the product has a chemical structure of the general formula of Figure 1, where the central unit, A, represents a radical of an aromatic hydrocarbon or an aromatic heterocyclic compound, which is substituted with three phosphonophenyl radicals, with the property of complexing with metal atoms, to result in porous metal-organic structures with predefined geometry of the structural channels
Patent LU-85264-A1 (LU)
Inventor: MAREN THOMAS H
IPC: A61K9/06
Filed: 1984-03-22
Abstract: Method and composition for reducing intraocular pressure and reducing aqueous humor formation by applying topically to the cornea an effective amount of an aqueous solution of a carbonic anhydrase inhinitor comprising a sulfonamide having the following properties: a. sufficiently soluble in water to form a 1-5%, by weight, solution or a pKa of not greater than 7.0;  b. ether partition coefficient of at least 1.0;  c. chloroform partition coefficient of at least 0.01; d. dissociation constant against carbonic anhydrase of not more than 3x10<-><8> molar; e. first order rate constant for penetration of the sulfonamide through a isolated rabbit cornea of at least 0.002 hr.<-><1>;  f. not injurious to the cornea; and g. stable in aqueous solution and in contact with the cornea.
Patent LU-85708-A1 (LU)
Title: Liq. extraction from aggregate by evaporation - e.g. in grain drying then recovering liq. in aerodynamic sepn. to condense liq.
Inventor: MALDAGUE PIERRE
IPC: F26B21/08
Filed: 1984-12-21
Abstract: A liq. is extracted from an aggregate by evapn. in a stream of carrier gas. Subsequently the evaporated liq. is sepd. from the gas in an aerodynamic separator where a pressure differential is established by a blower which drives the carrier gas. The aerodynamic separator has no moving parts and accelerates the mixt. into a throat region where it expands to produce droplets of the liq. The liq. droplets continue axially along the separator and are sepd. from the gas.
Patent MA-37610-A1 (MA)
Inventor: BETAGERI GURU V
IPC: A61K9/48
Filed: 2013-05-09
Abstract: يتعلق الاختراع الحالي بصيغ تستوستيرون جديدة حيث ينم تضمين التستوستيرون في نظام شحمي فسفوري / كوليسترول لإنتاج مشتت مسحوق جسيمي شحمي معزز. يمكن ان تتم صياغة مشتتات المسحوق الجسيمي الشحمي المعزز وفق الاختراع بسواغات مقبولة صيدلانيا لتكوين تركيبات صيدلانية. يتم الكشف عن الصور جرعات فموية مغلقة معويا, وطرق للعلاج البديل بالتستوستيرون.
Patent MA-38467-A1 (MA)
Title: Tricycle avec appui ischiatique
Inventor: NEERMAN JOHAN
IPC: B62K5/10
Filed: 2014-03-10
Abstract: L'invention concerne un tricycle (1), conçu pour déplacer un utilisateur, qui est plus ergonomique et plus facile à utiliser pour porter une personne, comprenant une roue avant (2), deux roues arrière (3), un châssis (4) reliant les roues (2, 3), comprenant sensiblement une section arrière fixe (4a) par rapport au plan de support des trois roues (2, 3) et une section avant (4b) capable de tourner latéralement, par rapport à la section sensiblement fixe (4a), autour d'un axe d'inclinaison (19) sensiblement dans la direction longitudinale du tricycle (1), un repose-pied (5) placé sur la section rotative (4b) et un support ischiatique (6) placé sur la section essentiellement fixe (4a).
Patent MA-50329-A1 (MA)
Title: Dispositif d’économie d’eau
Inventor: BEN ABDELLAH ABDELLATIF
IPC: E03C1/086
Filed: 2020-08-10
Abstract: Le save flux water est une innovation dans le domaine d'économie d'eau pour rendre les robinets plus économiques. Les.F.Wpermet de régler le débit d'eau à utiliser selon les besoins spécifiques. Le s.F.W permet d'économiser plus de 90 % par rapport au robinet simple.
Patent UY-27363-A1 (UY)
Title: Compuestos
Inventor: BASARAB GREG
Filed: 2002-06-28
Abstract: Compuestos que tienen la formula general y composiciones farmacéuticas que los contienen y sus uso o tratamiento o profilaxis de infección con H. pylori.
Patent UY-27905-A1 (UY)
Title: Composición herbicida y método para controlar malezas que utiliza la misma
Inventor: KAWASAKI HIROSHI
IPC: A01N33/18
Filed: 2003-07-23
Abstract: La invención provee una composición herbicida que consiste de 2-((4,6-dimetoxipirimidin-2-il)-hidroximetil)-6-metoximetil-N-difluorometansulfonil-anilida como componente (A) y cualquier compuesto seleccionado de más de 20 clases de compuestos específicos tales como orbencarb y lo similar como componente (B), hasta el presente no combinados con el compuesto componente (A). La dispensación de la composición herbicida a arrozales, prados, campos secos, o tierras no agrícolas brinda excelentes efectos de control de malezas sobre una variedad de malezas y causa ninguna o leve fitotoxicidad sobre plantas cultivadas valiosas.
Patent UY-30586-A1 (UY)
Title: Derivados de tartrato como inhibidores del factor de coagulacion ixa
Inventor: SCHREUDER DR HERMAN
IPC: A61K31/16
Filed: 2007-09-11
Abstract: Derivados de tartrato como inhibidores del factor de coagulacion IXa La invencion se refiere a compuestos de la formula I que tienen actividad antitrombotica, que en particular inhiben el factor de coagulacion de la sangre IXa, a procedimientos para su preparacion y a su uso como medicamentos.
Patent UY-30647-A1 (UY)
Title: Procedimiento e instalacion de produccion en continuo de un producto poroso en polvo
Inventor: ALAINF BRISSET
IPC: A23L7/10
Filed: 2007-10-16
Abstract: La invencion se refiere a un procedimiento de produccion de un producto poroso en polvo a partir de, al menos, un producto inicial pulverulento y/o viscoso, caracterizado porque se realizan las siguientes etapas en forma continua y sin exposicion al aire libre del producto: a)se prepara el producto inicial para llevarlo a un estado viscoso, b)en una máquina de tratamiento termomecánico , destinada a asegurar en forma continua al menos funciones de transporte y/o de mezcla para productos viscosos o ricos en materia seca, se disminuye la viscosidad del producto en estado viscoso sin cambiar su porcentaje de materia seca, por mezcla íntima con un gas inyectado en la máquina de tratamiento y se inicia simultáneamente una porosidad en el producto en estado viscoso, c) en continuidad con la máquina de tratamiento se intensifica la mezcla íntima de manera estática o dinámica del producto en estado viscoso con un gas para obtener una masa aireada y porosa, y d) se divide esta masa para obtener partículas aireadas y porosas.
Patent UY-31627-A1 (UY)
Title: Nuevas formas cristalinas del ácido 4-[4-(2-adamantilcarbamoíl)-5-ter-butil-pirazol-1-il]benzoico
Inventor: TOMKINSON GARY PETER
IPC: A61K31/415
Filed: 2009-02-03
Abstract: Se describen nuevas formas cristalinas del ácido 4-[4-2-adamantilcarbamoil)-5-ter-butil-pirazol-1-il]benzoico, su utilización en la inhibición de la enzima 11B(Beta)HSD1, procedimientos para obtenerlas y composiciones farmacéuticas que las contienen.
Patent ZW-10584-A1 (ZW)
Title: Production of phosphoric acid
Inventor: GUY NINEUIL
IPC: C01B33/08
Filed: 1984-07-04
Abstract: Phosphoric acid is produced, with concomitant recovery of solids comprising compounds of fluorine and silica, by (i) acidulating a first amount of phosphate ore with a strong acid to produce a first phosphoric acid slurry, (ii) filtering said first slurry to separate the liquid phosphoric acid content therefrom, (iii) concentrating a fraction of the phosphoric acid thus separated, (iv) recovering same, and (v) condensing the evolved vapors of concentration with a liquid absorbent to produce a solution of fluosilicic acid, (vi) acidulating a second amount of phosphate ore with said solution of fluosilicic acid together with a fraction of said first slurry, or together with a fraction of the phosphoric acid separated in the step (ii), to produce a second phosphoric acid slurry, (vii) filtering said second slurry to separate both the liquid phosphoric acid content and a solids fraction therefrom, said solids fraction comprising fluorine and silica compounds, (viiia) recycling the phosphoric acid thus separated from said second slurry to the step (i), or (viiib) combining same with the fraction of separated phosphoric acid to be downstream concentrated in the step (iii).