Patent DE-4446458-A1 (DE)
Title: Carbamoyl carboxylic acid amide derivs.
Inventor: WAGNER OLIVER DR
IPC: C07C271/54
Filed: 1994-12-27
Abstract: Carbamoyl carboxylic acid amide derivs. of formula (I) and their salts are new R<1> = 1-8C alkyl, 2-8C alkenyl, or 2-8C alkynyl (these gps. being opt. partially or completely halogenated and/or mono-, di- or tri-substd. with T gps.); 3-7C cycloalkyl or 3-7C cycloalkyl (these last 2 gps. being opt. partially or completely halogenated and/or mono-, di- or tri-substd. with T gps. (excluding cycloalkyl, cycloalkenyl and heteroaryl) or with 1-4C alkyl or aryl(1-4C)alkyl (this last gp. itself opt. substd. with T gps. excluding cycloalkyl or cycloalkenyl)); a non-aromatic 4-8 membered ring contg. in the ring, in addition to C, 1 or 2 heteroatoms chosen from O, S and N (the ring C being opt. mono-, di- or tri-substd. with halogen, 1-4C alkyl, T gps. (excluding cycloalkyl, cycloalkenyl and heteroaryl) and the second and any further N heteroatom carrying H or 1-4C alkyl); aryl or heteroaryl (these 2 gps. opt. mono-, di- or tri-substd. with halogen, 1-4C alkyl or T gps. (excluding cycloalkyl and cycloalkenyl)) or W<1>W<2>C=N; W<1> = 1-8C alkyl (opt. partially or completely halogenated and/or opt. mono-, di- or tri-substd. with T gps. (excluding alkoxycarbonyl, cycloalkyl and cycloalkenyl)), 2-8C alkenyl, 2-8C alkynyl (opt. partially or completely halogenated and opt. mono-, di- or tri-substd. with 1-4C alkyl or T gps. (excluding cycloalkyl, cycloalkenyl and heteroaryl), 3-7C cycloalkyl or 3-7C cycloalkenyl (opt. mono-, di- or tri-substd. with halogen, 1-4C alkyl, aryl(1-4C)alkyl (this last gp. itself opt. substd. with halogen, 1-4C alkyl or T gps., excluding cycloalkyl, cycloalkenyl or heteroaryl) or T gps. (excluding cycloalkyl, cycloalkenyl, aryloxy or heteroaryl)), aryl or heteroaryl (these last 2 gps. opt. substd. with T gps., excluding cycloalkyl, cycloalkenyl or heteroaryl); W<2> = H or a gp. W<1>; R<2> = H, 1-8C alkyl or 3-7C cycloalkyl (these last 2 gps. opt. partially or completely halogenated); R<3> = 1-8C alkyl, 3-7C cycloalkyl (opt. mono-, di- or tri-substd. with halogen, 1-4C alkyl, phenyl(1-4C)alkyl (in which the Ph gp. is opt. mono-, di- or tri-substd. with halogen, 1-4C alkyl or T gps., excluding cycloalkyl, cycloalkenyl, aryl, aryloxy or heteroaryl)); R<4> = one of the R<3> gps.; or R<3> and R<4> together with the C atom to which they are attached form a 4-8 membered ring which contains, in addition to C, 1 or 2 heteroatoms chosen from O, S and N (the ring C being opt. mono- or di-substd. with halogen, 1-4C alkyl and T gps. (excluding cycloalkyl, cycloalkenyl and heteroaryl) and the N heteroatom carrying H or 1-4C alkyl); R<5> = a R<2> gp.; X = H, 1-8C alkyl and/or 2-8C alkenyl (these last 2 gps. opt. partially or completely halogenated and opt. mono-, di- or tri-substd. with T gps., excluding cycloalkyl, cycloalkenyl or heteroaryl), 3-7C cycloalkyl and/or 3-7C cycloalkenyl (these 2 gps. opt. partially or completely halogenated and opt. mono-, di- or tri-substd. with 1-4C alkyl, aryl(1-4C) alkyl (this last opt. substd. with halogen, 1-4C alkyl and T gps., excluding cycloalkyl, cycloalkenyl and heteroaryl), or T gps. (excluding cycloalkyl, cycloalkenyl or heteroaryl)); m = 0-2; A = 3-7C cycloalkyl or 3-7C cycloalkenyl (opt. partially or completely halogenated and/or opt. mono-, di- or tri-substd. with 1-4C alkyl, aryl(1-4C)alkyl (thus last opt. mono-, di- or tri-substd. on aryl with halogen, 1-4C alkyl or T gps., excluding cycloalkyl, cycloalkenyl and heteroaryl) or T gps. excluding cycloalkyl, cycloalkenyl, aryloxy and heteroaryl); R<6> = aryl or heteroaryl (these gps. opt. mono-, di- or tri-substd. with halogen or T gps., excluding cycloalkyl, cycloalkenyl or heteroaryl); T = CN, 1-4C alkoxyalkyl, 1-4C haloalkyl, 1-4C alkoxy, 1-4C haloalkoxy, 1-4C alkylthio, 1-4C alkoxycarbonyl, 3-7C cycloalkyl, 3-7C cycloalkenyl, aryl, aryloxy or heteroaryl, the cyclic gps. themselves being opt. mono-, di- or tri-substd. with halogen, CN, 1-4C alkyl, 1-4C alkoxy alkyl, 1-4C haloalkyl, 1-4C alkoxy, 1-4C haloalkoxy, 1-4C alkylthio, 1-4C alkoxycarbonyl, aryl, aryloxy or heteroaryl.