baber/WOPTO huggingface dataset:
Patent BR-PI1008994-B1 (BR)
Title: método para produção de chapa de aço elétrica com grão orientado
Inventor: MAKOTO ATAKE
IPC: C21D9/46
Filed: 2010-03-04
Abstract: CHAPA DE AÇO ELÉTRICA COM GRÃO ORIENTADO E MÉTODO PARA PRODUÇÃO DA MESMA. A presente invenção refere-de a um método de produção de uma chapa de aço elétrica com grão orientado que inclui formar uma porção preferencialmente deformável em uma região final de uma chapa de aço de modo a ser paralela à direção de laminação da chapa de aço; bobinar a chapa de aço; e executar um recozimento final na chapa de aço após dispor a chapa de aço de maneira que a região final se torne o lado inferior da chapa de aço.
Patent BR-PI1010300-B1 (BR)
Title: processos para a preparação de um composto, de dronedarone, ou um sal do mesmo, de uma formulação farmacêutica, e de um intermediário de dronedarone, ou um sal do mesmo
Inventor: ANDERS BERGH
IPC: C07C239/20
Filed: 2010-04-06
Abstract: PROCESSOS PARA A PREPARAÇÃO DE UM COMPOSTO, PARA PREPARAR DRONEDARONE, OU UM SAL DO MESMO, E PARA PREPARAR UMA FORMULAÇÃO FARMACÊUTICA E fornecido um processo para a preparação de um composto da formula (II) em que R1, R2, R3 e R4 só como descritos na descrição. Tais compostos podem, por exemplo, ser intermediários úteis na síntese de medicamentos tais como Dronedarone.
Patent EA-000011-B1 (EA)
Title: Zilpaterol hydrochloride in a crystallized form and its preparation process
Inventor: CHEVREMONT YVES
IPC: A23K1/16
Filed: 1996-06-11
Abstract: Anhydrous crystalline zilpaterol hydrochloride (I), contg. less than 5% of crystals smaller than 15 mu , the rest of the crystals being smaller than 250 mu , is new. Also claimed are (I)-monohydrate and (I)-trihydrate. The claimed prepn. of (I) comprises: (i) forming a super-satd. soln. of (I) in water or in an ethanol/water mixt. at below 50 degrees C; (ii) cooling the soln. to crystallise the monohydrate; (iii) lowering the temp. to below 20 degrees C to crystallise the trihydrate; and (iv) drying to give the desired prod. A variation on the above procedure comprises dissolving (I) in water at below 30 degrees C to give a satd. aq. soln. from which the trihydrate recrystallises spontaneously. Alternatively, a soln. of (I) in a min. amt. of warm water (60-100 degrees C) is poured into a satd. soln. of (I) in a water/alcohol mixt. which has been previously stirred at below 20 degrees C and seeded with trihydrate, to give the trihydrate, which is then dried (all claimed).
Patent EA-002227-B1 (EA)
Title: Pharmaceutical compositions of peptides having low solubility in physiological medium
Inventor: RICHARDSON PETER
IPC: A61K38/09
Filed: 1998-05-26
Abstract: 1. A pharmaceutical composition comprising: a) an LHRH peptide agonist, an LHRH antagonist or a growth hormone releasing factor peptide as active ingredient; b) nicotinamide; and c) a physiological aqueous solution. 2. The pharmaceutical composition according to claim 1, wherein the active ingredient is an LHRH peptide antagonist. 3. The pharmaceutical composition according to claim 1 or claim 2, wherein the active ingredient is Antide or human GRF. 4. The pharmaceutical composition according to any one of claims 1 to 3, which is lyophilised and reconstitutable and further comprises one or more stabilizing agents. 5. The pharmaceutical composition according to any one of claims 1 to .4, which further comprises propylene glycol. 6. The pharmaceutical composition according to any one of claims 1 to 5, which is suitable for parenteral, oral, nasal or pulmonary administration route. 7. The pharmaceutical composition according to any one of claims 1 to 6, further comprising one or more pharmaceutically acceptable excipients. 8. The pharmaceutical composition according to any one of claims 1 to 7, which is suitable for injections. 9. The pharmaceutical composition according to any one of claims 1 to 8, which has the following composition ranges: antide or hGRF 0.1 - 20.0 mg nicotinamide 10 - 300 mg propylene glycol 0 - 800 mg aqueous phase, q.s. 1.0 ml.
Patent EA-001926-B1 (EA)
Title: Stabilized carbapenem intermediates and synthetic use
Inventor: WILLIAMS JOHN M
IPC: C07D477/00
Filed: 1998-06-12
Abstract: 1. A stabilized carbapenem intermediate compound represented by the formula 1:   or a salt thereof, wherein P represents a carboxyl protecting group and X<+> represents a charge balancing group. 2. A stabilized carbapenem intermediate compound in accordance with Claim 1 wherein P is selected from the group consisting of: benzhydryl, orto-nitrobenzyl, para-nitrobenzyl, 2-naphthylmethyl, allyl, 2-chloroallyl, benzyl, 2,2,2-trichloroethyl, trimethylsilyl, tert-butyldimethylsilyl, tert-butyldiphenylsilyl, 3-(trimethylsilyl)ethyl, phenacyl, para-methoxybenzyl, acetonyl, para-methoxyphenyl, 4-pyridylmethyl and tert-butyl. 3. A stabilized carbapenem intermediate compound in accordance with Claim 2 wherein P is selected from allyl and para-nitrobenzyl. 4. A stabilized carbapenem intermediate compound in accordance with Claim 1 wherein X<+> represents a member selected from the group consisting of: sodium, potassium, calcium and magnesium. 5. A process for synthesizing a compound represented by formula 2:   or a pharmaceutically acceptable salt or ester thereof, wherein X<+> is a charge balancing group, comprising deprotecting a compound of formula 1:   to produce a compound of formula 2. 6. A process in accordance with Claim 5 wherein the deprotection is conducted using hydrogen gas. 7. A process in accordance with Claim 6 further comprising purifying the compound using a hydrophobic resin. 8. A process in accordance with Claim 6 further comprising concentrating the compound in solution using a nanofiltration membrane. 9. A process in accordance with Claim 8 further comprising crystallizing the compound.
Patent EA-001787-B1 (EA)
Title: Pourable edible aqueous-continuous emulsions
Inventor: BIALEK JADWIGA MLALGORZATA
IPC: A23L35/00
Filed: 1998-06-24
Abstract: 1. A pourable, edible emulsion comprising a continuous non-gelled aqueous phase and a dispersed phase of gel particles, wherein the gel particles occupy from 20 to 70% of the volume of the aqueous phase and the gel particles comprise hard particles of biopolymer gel and soft particles of biopolymer gel. 2. An emulsion as claimed in Claim 1 wherein the gel particles occupy from 30 to 60% of the volume of the aqueous phase. 3. An emulsion as claimed in Claims 1 or 2 wherein the hard particles are gels of biopolymers selected from the group consisting of kappa-carrageenan, agar, protein, alginate, gellan and mixtures thereof. 4. An emulsion as claimed in Claim 3 wherein the soft particles are gels of biopolymers selected from the group consisting of iota-carrageenan, gelatinised starch, pectin, protein, alginate, gellan and mixtures thereof. 5. A process for preparing a pourable, edible emulsion comprising the steps of: a) preparing hard particles of biopolymer gel and/or soft particles of biopolymer gel; and b) admixing a non-gelled aqueous phase and the hard particles and/or the soft particles to form an emulsion comprising a continuous non-gelled aqueous phase and a dispersed phase of particles of biopolymer gel occupying from 20 to 70% of the volume of the aqueous phase. 6. A process as claimed in Claim 5, wherein the soft particles of biopolymer gel are prepared by dispersing at least one soft-gelling biopolymer in water, heating to a temperature above the gel transition temperature of the biopolymer and cooling under shear to a temperature below the gel transition temperature of the biopolymer. 7. A process as claimed in Claim 5, wherein the hard particles of biopolymer gel are prepared by dispersing at least one hard-gelling biopolymer in water, heating to a temperature above the gel transition temperature of the biopolymer and cooling under shear to a temperature below the gel transition temperature of the biopolymer.
Patent EA-004873-B1 (EA)
Title: A method for determining the presence of papillomatous digital dermatitis antigen in a sample of ruminant serum
IPC: A61K39/00
Filed: 1997-07-31
Abstract: A method for determining the presence of Papillomatous Digital Dermatitis (PDD) antigen in a sample of ruminant serum comprising contacting said sample with an antibody, reacting with Seroens spp. bacterin under conditions capable of binding PDD antigen with an antibody forming antigen/antibody complex, and detecting antigen in said sample based on detection of the antigen/antibody complex.
Patent EA-003660-B1 (EA)
Title: Method for processing solid wastes from sludge in aluminum production
Inventor: MIRSAIDOV ULMAS
IPC: C22B7/00
Filed: 2001-08-03
Abstract: 1. A method for processing solid wastes from sludge, comprising the steps of sludge sintering, grinding, cake leaching with water and pulp filtering, characterized in that the sludge is sintered without preliminary washing from sulfates and carbonates. 2. The method of claim 1, characterized in that the sludge is sintered at a continuous air access at 750 to 850 degree C during 20-40 minutes. 3. The method of claim 1, characterized in that the sludge is ground at 70-80 degree C with ratio solids/liquid from 1:3 to 1:5 during 30-60 minutes. 4. The method of claim 1 and 3, characterized in that the solid waste comprising cryolite and alumina is used as raw material after drying at 100-150 degree C during 30-60 minutes. 5. The method of claim 1 and 3, characterized in that a solution comprising sodium hydroaluminate is used as alkali coagulant.
Patent EA-005357-B1 (EA)
Title: Cam block drive for a zig zag sewing machine
Inventor: UMYAROV RAVIL KONSTANTINOVICH
IPC: D05B3/02
Filed: 2003-06-05
Abstract: A cam block drive is intended for using in zig zag sawing machines, having a plurality of cams for producing zig zag-like decorative, special etc stitches and provides for increasing operation reliability. The drive is designed as a wavy tooth gearing with rigid links with conic wheels. A driven wheel made integrated with the cam block and a satellite wheel are mounted on the main shaft. Wherein the first wheel is mounted freely thereon, while the second by a spherical bushing and fixed against turn in the plane, perpendicular to the man shaft axis, but may perform oscillating motion relative to the spherical bushing center and oscillating motion relative to the holder axis arranged in the horizontal groove, made in the machine's farm. Oscillating motion are provided due to interacting of the satellite end face with the wave generator - face cam affixed on the main shaft.
Patent EA-009388-B1 (EA)
Title: Expression vectors and methods for use thereof
Inventor: KROHN KAI
IPC: C12N15/86
Filed: 2002-05-03
Abstract: The present invention relates to novel vectors, to DNA vaccines and gene therapeutics containing said vectors, to methods for the preparation of the vectors and DNA vaccines and gene therapeutics containing the vectors, and to therapeutic uses of said vectors. More specifically, the present invention relates to novel vectors comprising (a) an expression cassette of a gene of a nuclear-anchoring protein, which contains (i) a DNA binding domain capable of binding to a specific DNA sequence and (ii) a functional domain capable of binding to a nuclear component and (b) a multimerized DNA sequence forming a binding site for the anchoring protein, and optionally (c) one or more expression cassettes of a DNA sequence of interest. In particular the invention relates to vectors that lack a papilloma virus origin of replication. The nuclear-anchoring protein might be the E2 protein of Bovine Papilloma Virus type 1 or Epstein-Barr Virus Nuclear Antigen 1. The invention also relates to vectors that lack an origin of replication functional in a mammalian cell. The invention further relates to methods for expressing a DNA sequence of interest in a subject.
Patent EA-005776-B1 (EA)
Title: A method of diagnosing or prognosticating major respiratory bacterial pathogens in a subject
Inventor: EUGEN-OLSEN JESPER
IPC: G01N33/569
Filed: 2002-05-21
Abstract: A method of diagnosing and/or prognosticating respiratory bacterial infections in a subject comprising the steps of (a) performing in vitro a measurement of the level of a marker in the form of (i) urokinase plasminogen activator receptor (uPAR), (ii) soluble urokinase plasminogen activator receptor (suPAR) and/or (iii) one or more degradation products of (i) or (ii) in a biological fluid sample from a subject, and (b) using the measurement value obtained to evaluate the state of the subject. Especially Streptococcus pneumoniae and Mycobacterium tuberculosis infections may be diagnosed and/or prognosticated.
Patent EA-007763-B1 (EA)
Title: Dose dial and drive mechanism suitable for use in drug delivery devices
Inventor: VEASEY ROBERT FREDERICK
IPC: A61M5/315
Filed: 2004-03-22
Abstract: The invention relates to a dose dial and drive mechanism for use in a drug delivery device comprising a housing (2); a dose dial sleeve (50); a piston rod (10); a drive sleeve (26) is threadedly connected to the said piston rod (10); a reset sleeve (30), which is located between said drive sleeve (26) and said housing (2); and a dose display. When said dose dial sleeve travels towards the second end of said housing the reset sleeve is carried with said dose dial sleeve towards the second end of said housing resetting said dose display to a zero position; and when said dose dial and/or the reset sleeve travels towards the first end of said housing, the said dose dial sleeve and/or reset sleeve engage(s) with said drive sleeve thus advancing both said drive sleeve and said piston rod towards the first end of said housing.
Patent EA-008716-B1 (EA)
Title: Respirators
Inventor: SUTTON ROBERT CHARLES
IPC: A62B18/02
Filed: 2005-03-17
Abstract: A respirator comprising an outer mask (2) in which is defined a main volume (16) and an oronasal mask (4) located within the outer mask and defining a secondary volume (17). Air for breathing enters the mask (2) via a one-way valve (9) and filter (10). Exhaled air exits the mask (4) via an exhale conduit (5) fitted with an exhale valve (6). A conduit (11) is provided for the passage of air from the outer mask (2) to the oronasal mask (4). The conduit (11) is fitted with a one-way valve (12) and a filter (13). The filter (13) is such as to filter either particular or vapour challenges, or a mixture of these, as required.
Patent EA-015056-B1 (EA)
Title: Construction payment management system and method with document tracking features
Inventor: ALLIN PATRICK J
IPC: G06Q20/00
Filed: 2007-03-22
Abstract: A system and method of managing a construction payment process involving a plurality of participants associated with the construction project and at least one document to be transferred between at least two participants of the plurality participants during the course of the construction project. One method can include assigning at least one enforcement action to the at least one document wherein the enforcement action is automatically effected if the document is not transferred between the at least two participants.
Patent EA-015417-B1 (EA)
Title: Pesticide formulations which risk crystallisation and process for producing the same
Inventor: CASANA GINER VICTOR
IPC: A01N25/22
Filed: 2006-09-25
Abstract: Formulations are disclosed which contain pesticides which risk crystallising in water when the formulation which contains the pesticides as active ingredients is dissolved. The present formulations are characterised by long half-life ("shelf stability"), long crystallisation time once the formulation is dissolved in water, improved wettability and excellent emulsion stability.
Patent EA-015486-B1 (EA)
Title: Method of self-sealing damp-proof bulkhead erection
Inventor: USENKO VIKTOR SEMENOVICH
IPC: E21F5/00
Filed: 2009-04-24
Abstract: The invention concerns mining engineering and may be used for isolation of wet ground of working from a mining zone. The method includes formation of a triangular profile cut along the contour of working and assembly of bulkhead from separate pieces. On the planes of the cut joint sealing inserts are fastened, wooden square and triangular elements with end parts that are sheared wedgewise in the form of the cut are installed, interelement moisture barriers are laid. The assembly of the bulkhead elements is completed with installation of square composite element into the cut; intracut and interelement joint sealing inserts are made of flexible material and/or solidifying sealant. In weakened, fractured, vulnerable to dissolution and other rock masses which do not secure sufficient mechanical reliability and are prone to filtration of water (brine) a cement screen around the bulkhead and/or reinforced concrete gantry between the bulkhead body and rock mass are additionally erected in the adjacent strata. If calculated values of hydrostatic head exceed the values allowed from the view point of strength and leakproofness of the bulkhead, as well as in order to reduce filtration into the protected zone of opening an additionalself-sealing damp-proof bulkhead is erected which fills the space between bulkheads with reinforcing and waterproof material, for example, concrete. The proposed method allows to raise efficiency of damp-proofing of workings.
Patent EA-020741-B1 (EA)
Title: Method for diagnosis of parts of a combustion engine
Inventor: KOLTUNOV GEORGY ANATOLIEVICH
IPC: G01M15/00
Filed: 2011-08-01
Abstract: The object of the invention is a method for diagnosis of parts of internal combustion engine. The invention relates to industry, in particular, to operation of machines and can be used at diagnostics of parts of internal combustion engines. The method for diagnosis of parts of internal combustion engine comprises installation of oil filter with main filtering element (fine filter) and filtering element of bypass valve (coarse filter) cleaning oil passing through the bypass valve to engine, with its following dismantling, filter opening and analysis of filtered wear products by qualitative and quantitative composition of those and attribution to parts of the engine. The technical result provides enhancement of accuracy evaluation of technical condition of internal combustion engines and parts thereof, including aluminium, plastic, cast iron, steel parts, sealants, etc.
Patent EA-020346-B1 (EA)
Title: Method for the preoperative determination of the intraoperative risk of bleeding of a patient
Inventor: KORTE WOLFGANG
IPC: G01N33/86
Filed: 2009-07-23
Abstract: In order to determine the intraoperative risk of bleeding preoperatively, both the content of fibrin monomer (FM) and the partial thromboplastin time (PTT) are determined in a blood or plasma sample.
Patent EA-025329-B1 (EA)
Title: Methods for prophylaxis or preventing recurrences or treating breast cancer
Inventor: FLOCH JEAN-FRANCOIS
IPC: C07K16/26
Filed: 2011-01-07
Abstract: The invention relates to methods of treating and preventing breast cancer or recurrence of breast cancer with a monoclonal anti-progastrin antibody.
Patent EA-026217-B1 (EA)
Title: Inhalator for inhalation of measured doses
Inventor: KARG JEFFREY A
IPC: A61M15/00
Filed: 2011-05-18
Abstract: The invention discloses an inhalator for inhalation of measured doses, wherein the inhalator comprises a main body having a cavity for a container capable of accommodating a container with a medicinal substance for its movement in said cavity, and a dose counter; the dose counter has a drive link at least a section of which is positioned in the cavity for the container for actuation of motion of the container with a medicinal substance; the cavity for the container has an inside wall and the first container support structure on the inside wall disposed immediately beside the drive link. The dose counter, except for at least said section of the drive link, is arranged in the counter chamber separately from the cavity for the container, the drive link including a finger that extends through a hole in the wall separating the counter chamber from the cavity for the container. This provides an important advantage since the first support structure makes it possible to prevent excessive swinging of the container relative to the main body of the inhaler. Since the container can control the drive link, this improves significantly dose count and permits avoiding errors in count.
Patent EA-024346-B1 (EA)
Title: Device and gantry for suspending a component
Inventor: TROEGL ARNOLD
IPC: F16M13/02
Filed: 2013-07-19
Abstract: The invention relates to a device (8) for suspending at least one component (3) from a gantry (1), wherein the device includes a guide rail (9) that can be secured on the gantry (1) in an approximately vertical orientation; a carriage (10) that is guided on the guide rail (9) in a sliding movable manner and on which the component (3) can be mounted; and a limit stop (11) that is mounted on the guide rail (9) beneath the carriage (10) in a height-adjustable manner; wherein the guide rail (9) is divided into a lower part (9') and an upper part (9''), which are connected to each other by way of a pivot connection (14) having a pivot axis (15) parallel to the longitudinal direction (12) of the guide rail (9). The invention also relates to the gantry (1) comprising the device (8).
Patent EA-025035-B1 (EA)
Title: Bridged piperidine derivatives
Inventor: BAUMANN KARLHEINZ
IPC: C07D519/00
Filed: 2012-02-28
Abstract: The present invention relates to compounds of formulawherein hetaryl I, hetaryl II, R, R, R, Y, p, m, n, o are as defined in the claims; or to pharmaceutically active acid addition salts thereof. The present compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.
Patent EA-026390-B1 (EA)
Title: PHARMACEUTICAL COMPOSITIONS OF 7-(6-(2-HYDROXYPROPAN-2-YL)PYRIDIN-3-YL)-1-((TRANS)-4-METHOXYCYCLOHEXYL)-3,4-DIHYDROPYRAZINO[2,3-b]PYRAZIN-2(1H)-ONE, SOLID FORMS THEREOF AND METHODS OF THEIR USE
Inventor: CONNOLLY TERRENCE JOSEPH
IPC: C07D487/04
Filed: 2012-11-30
Abstract: Provided herein are compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, solid forms, isotopologues and metabolites thereof, and methods of their use for the treatment of a disease, disorder, or condition.
Patent EA-028004-B1 (EA)
Title: Lighting installation
Inventor: NALICHAEV ILYA BORISOVICH
IPC: F21V29/56
Filed: 2015-04-07
Abstract: The invention relates to outdoor illumination devices, used primarily in emergency situations. It is designed to be used in cases of power supply interruption during accidents and catastrophes, and in cases of conducting construction or repair or rescue operations in the night time. The technical result is higher reliability and better service qualities of the lighting installation. The lighting installation comprises a base, an inflatable shell fastened to the base, an air blower in communication with the shell cavity, and at least one light source accommodated in the shell. The lighting installation is equipped with a hollow module secured inside the shell and carrying the light source, the module cavity being in communication with the light source cooling system. The light source is of LED type, and the cooling system uses liquid as the cooling medium and includes a pump connected to the module cavity by means of flexible pipes.