baber/WOPTO huggingface dataset:
Patent CA-2601157-A1 (CA)
Title: Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors
Inventor: GRIFFIN GRAEME
IPC: G01N33/74
Filed: 2006-03-16
Abstract: The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an EGFR  kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an EGFR kinase inhibitor, comprising assessing whether the tumor cell has undergone an epithelial to mesenchymal transition (EMT), by determining the expression level of epithelial and/or mesenchymal biomarkers, wherein tumor cells that have undergone an EMT are substantially less sensitive to inhibition by EGFR kinase inhibitors. Improved methods for treating cancer patients with EGFR kinase inhibitors that incorporate the above methodology are also provided. Additionally, methods are provided for the identification of new biomarkers that are predictive of responsiveness of tumors to EGFR kinase inhibitors. Furthermore, methods for the identification of agents that restore the sensitivity of tumor cells that have undergone EMT  to inhibition by EGFR kinase inhibitors are also provided.
Patent CA-2601674-A1 (CA)
Title: Process for the preparation of opioid modulators
Inventor: HE WEI
IPC: C07D217/26
Filed: 2006-03-06
Abstract: The present invention is directed to novel processes for the preparation of opioid modulators (agonists and antagonists) and intermediates in their synthesis. The opioid modulators are useful for the treatment and prevention of as pain and gastrointestinal disorders.
Patent CA-2608014-A1 (CA)
Title: Substituted oxadiazole derivatives as positive allosteric modulators of metabotropic glutamate receptors
Inventor: MUTEL VINCENT
IPC: A61K31/454
Filed: 2006-05-17
Abstract: The present invention relates to new compounds which are Oxadiazole derivatives of formula (I) wherein B, P, Q, W, R1 and R2 are defined in the description. Invention compounds are useful in the prevention or treatment of central or peripheral nervous system disorders as well as other disorders modulated by mGluR5 receptors.(I).
Patent CA-2610571-A1 (CA)
Title: Metathesis process for preparing an .alpha.,.omega.-functionalized olefin
Inventor: TIMMERS FRANCIS J
IPC: C07C69/533
Filed: 2006-06-02
Abstract: A cross-metathesis process for preparing an .alpha., .omega.-functionalized olefin, such as methyl 9-decenoate, and an .alpha.-olefin having three or more carbon atoms, such as 1-decene. The process involves contacting in a first reaction zone an .alpha.-functionalized internal olefin, such as methyl oleate, and an .alpha.-olefinic monomer having three or more carbon atoms, such as 1-decene, with a first metathesis catalyst to prepare an effluent stream containing the .alpha., .omega.-functionalized olefin, such as methyl 9-decenoate, an unfunctionalized internal olefin, such as 9-octadecene, unconverted reactant olefins, and optionally, an .alpha., .omega.-difunctionalized internal olefinic dimer, such as dimethyl 9-octadecen-1,18-dioate; separating said effluent streams; then contacting in a second reaction zone the unfunctionalized internal olefin with ethylene in the presence of a second metathesis catalyst to obtain a second product effluent containing the .alpha.-olefinic monomer having three or more carbon atoms; and cycling a portion of the .alpha.-olefinic monomer stream(s) to the first reaction zone.
Patent CA-2611936-A1 (CA)
Inventor: BORODIC GARY E
IPC: A61P25/22
Filed: 2006-06-07
Abstract: The invention provides methods for treating primary disorders of mood and affect, including depressive disorders, anxiety and sleep disorders and CNS  disorders comprising the administration of a neurotoxin.
Patent CA-2612442-A1 (CA)
Title: Heterotetracyclic compounds as tpo mimetics
Inventor: ALPER PHILLIP
IPC: C07D491/04
Filed: 2006-07-14
Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia.
Patent CA-2615820-A1 (CA)
Title: Downhole tool with pivotally mounted extendable assembly
Inventor: MOYES PETER BARNES
IPC: E21B23/06
Filed: 2006-07-21
Abstract: Disclosed herein is a device that relates to a downhole tool (10). The tool comprising, a tool body (14) having first (24) and second (26) support portions, and at least one extendable assembly (18) pivotally mounted between the first and second support portions. The extendable assembly is reconf igurable between a retracted configuration and an extended configuration by relative movement of the support portions.
Patent CA-2616757-A1 (CA)
Inventor: KAILAS SIVAKUMAR
IPC: H04L45/24
Filed: 2006-07-26
Abstract: A mesh network, operating as a virtual Ethernet switch, includes multiple nodes operating as Mesh Network Gateway Interfaces (mesh NGIs) enabled for communication with one or more shared access networks. Selectively coupling the multiple NGIs to the same shared access network provides redundancy and load balancing aimed at improving the reliability and performance of the network. A first architecture is based on a gateway group, including a plurality of NGIs enabled to communicate with a single shared access network via a designated broadcast server elected from among the NGIs. A second architecture is based on a plurality of (physical) NGIs enabled to communicate with a single shared access network via one or more designated nodes in the shared access network. The designated nodes, or Mesh Servers (MSs), operate as virtual NGIs, and traffic entering or exiting the mesh flows through one of the MSs, thus improving packet broadcast efficiency.
Patent CA-2619637-A1 (CA)
Inventor: PELOQUIN RICHARD L
IPC: C09J7/10
Filed: 2006-08-22
Abstract: The present application is directed to adhesive articles and release liners.  Namely, the present application is directed to an article comprising an adhesive layer with a structured surface. The structured surface comprises a first groove and a second groove recessed into the adhesive layer from a reference plane defined by the adhesive surface on either rim of the groove.  In some embodiments, the second groove is contained within the first groove, and in other embodiments the grooves are separate. The first groove and the second groove have walls. The wall angle of the first groove with respect to the reference plane is non-zero and is smaller than the wall angle of the second groove with respect to the reference plane. The application is also directed to release liners for the adhesive article, wherein the surface of the release liner is the inverse of the adhesive surface.
Patent CA-2621946-A1 (CA)
Title: Improvements in and relating to service oriented architecture
Inventor: PATON DEREK JOHN
IPC: G06Q10/00
Filed: 2006-09-07
Abstract: A computer system and method of using a service oriented architecture (SOA) which runs business service application in a distributed network. The system has a channel dependent client layer containing a presentation layer and an application control layer, a channel independent service layer containing a business service layer and a data service layer and an integration layer. The integration layer can receive requests for service from the client layer and has a message generator for sending a request message to the service layer which is adapted to read the request message and in response, to run the business service application.
Patent CA-2626290-A1 (CA)
Title: Meat cutter
Inventor: EICHERT CHRISTIAN
IPC: B02C18/20
Filed: 2006-10-19
Abstract: A meat cutter, a blade head and an associated cutter blade (11, 12) are proposed, in which the complexity with respect to assembly and disassembly and with respect to the diversity of the parts, and the potential danger during assembly and disassembly, is reduced. This is achieved according to the invention by the fact that the blade foot (2) of the cutter blade (11, 12) has a toothing structure (8) with projections (9) and recesses (10), which points towards the drive shaft (19) and by means of which the cutter blade (11, 12) can be positioned in a rotationally secure manner in a matching toothing structure (14), by being pushed on in the axial direction.
Patent CA-2626443-A1 (CA)
Inventor: AZIMIOARA MIHAI
IPC: A61K31/427
Filed: 2006-11-07
Abstract: The invention provides compounds (I) pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR.delta..
Patent CA-2629890-A1 (CA)
Inventor: ANDERSON ROBERT J
IPC: H04B7/00
Filed: 2006-11-13
Abstract: A method and system for enhancing the performance of augmented services associated with a wireless communications system through the dynamic exploitation of current measurements and operational configuration parameters to accurately and effectively control the signal power and duration transmitted by the mobile unit of interest.
Patent CA-2630810-A1 (CA)
Inventor: JAMES KENNETH
IPC: G01N23/06
Filed: 2006-11-21
Abstract: The invention is a method and apparatus for performing a radiation scan of a structure (10) by arranging a source (18) of penetrating radiation and a radiation detector (20) at opposed ends of a radiation path through the structure, oriented in such a way that the source emits radiation along the path through the structure and the detector is capable of detecting the radiation after it has passed through the structure and monitoring the radiation emitted from the source that is detected by the detector; comprising mounting at least one continuous loop of a cable (16) on the structure between at least two fixed locations (22, 24) on said structure so that the cable is movable along its length relative to the structure, fixing at least one of the source of penetrating radiation and the radiation detector to the cable, arranging the other of the source and detector to emit radiation to or detect radiation from the source or detector that is fixed to the cable, monitoring the radiation received by the detector when the cable is in a first position, moving the cable along its longitudinal axis to move the source or detector fixed to the cable to a second position relative to said structure and monitoring the radiation received by the detector in the second position.  Preferably both source and detector are fixed to the cable so that movement of the cable moves the source and detector by the same distance in the same direction.
Patent CA-2631078-A1 (CA)
Inventor: PAYNTER JEFFREY
IPC: H01R24/20
Filed: 2008-05-09
Abstract: An angled coaxial cable connector, having a unitary generally cylindrical inner conductor coaxial within a bore extending between a primary side and a secondary side of an outer body. The inner conductor provided with a first end on a primary longitudinal axis having a transition to a second end on a secondary axis at an angle to the primary longitudinal axis. An outer side of the transition having a planar back angle surface, the planar back angle surface arranged at generally one half of the angle to the longitudinal axis and to the secondary axis, respectively.
Patent CA-2631433-A1 (CA)
Title: Controller of vehicle
Inventor: TAKENAKA TORU
IPC: B60W10/18
Filed: 2006-12-21
Abstract: A control input for drive/brake force operation of one or more specific wheels, i.e. a k-th wheel, out of a plurality of wheels of a vehicle is determined to satisfy the requirements for the relation between a road surface reaction acting on the k-th wheel from the road surface depending on the detection values or estimated values of the road surface reaction and the frictional characteristics of the k-th wheel, a feedback control input concerning the drive/brake force of the k-th wheel for bringing the difference between the quantity of state and a model quantity of state of the vehicle close to 0, a feed forward control input of drive/brake force dependent on a drive controlled variable by the driver of the vehicle, and a control input for drive/brake force operation of the k-th wheel. Consequently, actual motion of the vehicle can be controlled to a desired motion while taking account of the characteristics of road surface reaction acting to the wheel from the road surface appropriately.
Patent CA-2632089-A1 (CA)
Inventor: SENECAL SHAUN
IPC: G06Q10/00
Filed: 2008-05-23
Abstract: A computer-readable storage medium includes executable instructions to generate a context definition. A query is generated against a data source based on data requirements specified in the context definition. The query is executed against the data source to generate a data source result. The data source result is stored in a report document. A data view for the context definition comprises specific values for the context definition and characterizes the data in the report document. The data view is stored in the report document.
Patent CA-2632311-A1 (CA)
Inventor: SPEIDEL THOMAS
IPC: B22D23/00
Filed: 2006-07-08
Abstract: A casting method for producing a cast part (5) with a mould (1, 51) provides for a container (2) to be filled with the molten metal to be poured, for the container (2) to be connected to the mould (1, 51) in a sealing manner, for the mould (1, 51) and the container (2) to be rotated together, such that the molten metal flows out of the container (2) into the mould (1, 51), then for the mould (1, 51) and the container (2) to be separated from one another and for the cast part (5) to be removed from the mould (1, 51). A casting plant for carrying out the method has a mould (1, 51) which is pivotably mounted about a first rotation axis (4) and a container (2) which is pivotably mounted about a second rotation axis (23). In order to enable the mould (1, 51) to be moved over the container (2), provision is made for the mould (1, 51) to be movably mounted in a second direction of movement.
Patent CA-2637938-A1 (CA)
Inventor: THEIMER ANTHONY ROY
IPC: H01R4/64
Filed: 2007-01-22
Abstract: A high-pressure connector for an electrical power cable section having a central stranded conductor encased in a polymeric insulation jacket and having an interstitial void volume in the region of the stranded conductor, the high-pressure connector being suited for confining a fluid within the interstitial void volume at a residual pressure above atmospheric, but below the elastic limit of the polymeric insulation jacket, the high-pressure connector comprising a housing having a wall defining an interior chamber configured to be in fluid communication with the interstitial void volume and an end portion sized to receive the insulation jacket within the interior chamber and to overlap at least a portion of the insulation jacket at an end thereof with the cable section extending from the housing end portion and at least a portion of the stranded conductor positioned within the interior chamber. The housing wall of the housing end portion has an engagement portion comprised of a swagable material to secure the housing wall to the insulation jacket in fluid-tight sealed engagement therewith upon inward swaging of the engagement portion of the housing wall of the housing end portion to the insulation jacket to confine the fluid at the residual pressure within the interior chamber and the interstitial void volume. The housing includes at least one axially-projecting engagement member located within the interior chamber at the engagement portion of the housing wall of the housing end portion.
Patent CA-2640159-A1 (CA)
Inventor: MURANO ERMINIO
IPC: A61P35/00
Filed: 2007-01-25
Abstract: The present invention refers to a drug delivery system consisting of hyaluronic acid and a therapeutic active agent.
Patent CA-2641159-A1 (CA)
Inventor: WEST STACEY H
IPC: F21Y101/00
Filed: 2007-02-05
Abstract: A portable electronic device, such as a flashlight, with a circuit for reducing the initial surge of current that is sent through the lamp filament when a flashlight is turned on is provided. The circuit reduces the stresses placed on the lamp bulb when it is turned on, thereby extending the life expectancy of the lamp bulb. A flashlight with beacon mode that produces light according to a duty cycle of less than 11% is also disclosed.
Patent CA-2641607-A1 (CA)
Title: Method for the manufacturing of microfibrillated cellulose
Inventor: HENRIKSSON GUNNAR
IPC: D21H11/20
Filed: 2007-01-31
Abstract: The present invention provides a method for treatment of chemical pulp for the manufacturing of microfibrillated cellulose comprising the following steps: a) providing a hemicellulose containing pulp, b) refining said pulp in at least one step and treating said pulp with one or more wood degrading enzymes at a relatively low enzyme dosage, and c) homogenizing said pulp thus providing s aid microfibrillated cellulose. According to a second aspect of the invention a microfibrillated cellulose obtainable by the method according to the first aspect is provided . According to a third aspect of the invention, use of said microfibrillated cellulose according to the second aspect in food products, paper products, composite materials, coatings or in rheology modifiers (e.g.  drilling muds) is provided .
Patent CA-2641665-A1 (CA)
Title: Modified release formulation
Inventor: FRIEDL THOMAS
IPC: A61P25/16
Filed: 2007-02-09
Abstract: The invention is directed to the use of an extended release tablet formulation for pramipexole.
Patent CA-2643130-A1 (CA)
Title: Compounds and methods of treating disorders associated with activation of metachromatic cells
Inventor: MAGHNI KARIM
IPC: A61K31/4704
Filed: 2007-02-22
Abstract: The present invention relates to neurokinin- 1 (NK-1) receptor antagonists in combination with an inhibitor of metachromatic cell activation, such as an anti- inflammatory agent, an immunosuppressor, or a kinase inhibitor, and use of such combinations in the treatment of disorders associated with activation of metachromatic cells. Disorders associated with the activation of metachromatic cells include allergic/non-allergic rhinitis, allergic/non-allergic asthma, allergic/non-allergic urticaria, immuno-infiammatory disorders, metachromatic cell-related autoimmune disorders, transplant rejection, and other metachromatic cell-related disorders.
Patent CA-2645803-A1 (CA)
Title: Mechanical expansion system
Inventor: GIROUX RICHARD LEE
IPC: E21B43/10
Filed: 2008-12-05
Abstract: Methods and apparatus enable expanding a tubular in a wellbore. The method and apparatus include running a bottom hole assembly (BHA) into a wellbore.  The BHA is anchored to the wellbore and a portion of the BHA is released from the anchor.  An expansion member is then pulled by a work string through the tubular thereby engaging the tubular with the wellbore. The work string is reconnected to the anchor and used to release the anchor. The BHA is then removed from the wellbore.
Patent CA-2649248-A1 (CA)
Inventor: CAUSSIN YVES
IPC: H05K5/04
Filed: 2009-01-12
Abstract: The invention relates to a housing (100) made of metal extruded section member for manufacturing a multi-position waterproof power electronic device (200), the extruded section member forming a tunnel that is of substantially rectangular closed section and that is provided with fins (110) on at least one side of the rectangle (102, 104), said fins (110) allowing air to flow outside the housing (100) by natural convection in the extrusion direction (X), a side (101) that is not provided with fins being designed to serve as a base for fastening the housing (100) and as a support for power electronic components of the power electronic device (200). According to the invention, the fins (110) are machined transversely to the extrusion direction (X) so as to form notches (111) in the fins (110), said notches (111) being aligned in succession in an "optimum"  direction (OP) that forms an angle with the extrusion direction (X) that is optimized as a function of a predetermined preferred installation direction, and said notches (111) being of geometrical shape such that they allow air to flow outside the housing (100) by natural convection in the optimum direction (OP).
Patent CA-2650576-A1 (CA)
Inventor: CADE DANIEL
IPC: A61B5/00
Filed: 2006-04-13
Abstract: L'invention concerne un dispositif de surveillance pouvant être porté par un individu nécessitant une surveillance et qui comprend : un ou plusieurs éléments de détection permettant de détecter des informations cardio, respiratoires, physiologiques et/ou autres informations relatives à l'individu ; des moyens de traitement permettant d'analyser les informations détectées ; des moyens de mémoire permettant de stocker les informations détectées et/ou analysées ; et des moyens de communication permettant de transmettre au moins les informations analysées. Au moins une forme d'onde acquise à partir des informations cardio, respiratoires, physiologiques et/ou autres informations est numérisée en temps réel ; une analyse des informations détectées et/ou numérisées est effectuée en temps réel et des indications relatives au bien-être de l'individu sont calculées en temps réel ; et les indications calculées relatives au bien-être de l'individu sont transmises par les moyens de communication et/ou stockées dans les moyens de mémoire.
Patent CA-2651443-A1 (CA)
Inventor: WINTER PAUL
IPC: F24H9/20
Filed: 2009-01-28
Abstract: A system for changing the temperature (T1) of a fluid such as an on-demand water heater is disclosed. The system comprises an input for receiving the fluid at a first temperature (T1) and an output for delivering the fluid at a second temperature (T2). A  conduit connects the input to the output, and comprising means such as a heating element for altering the temperature. The system has one or more virtual sensors for estimating the fluid temperature within the conduit. The system comprises a processor having a temperature estimating program for estimating temperature based on an estimate of the heat transfer between the fluid and the conduit. The processor provides a controller with the estimated temperature. The controller subsequently generates a control signal for the temperature altering means. The system thus provides accurate fluid temperature control without suffering from the slow responsiveness that usually mars sensor-based systems.
Patent CA-2652092-A1 (CA)
Title: Face authentication device, face authentication method, and face authentication program
Inventor: YAMASHITA MASAO
IPC: G06V10/60
Filed: 2006-05-23
Abstract: When a human sensor detects a person to be authenticated, an illumination unit acquires environmental illumination intensity measured by an illumination intensity sensor, determines illumination intensity by using illumination intensity conversion information that is information representing illumination intensity according to environmental illumination intensity, and controls illumination intensity of a light source so that it emits light with the determined illumination intensity. In the above, the illumination intensity according to the environmental illumination intensity is determined such that, when the environmental illumination intensity is low, the illumination intensity is low and such that, when the environmental light intensity is high, the illumination intensity is high. A face authentication terminal authenticates the person with illumination made by the illumination unit.
Patent CA-2652510-A1 (CA)
Inventor: CHALKER VICKI
IPC: C12Q1/70
Filed: 2007-05-24
Abstract: There is provided a method for detecting M. genitalium nucleic acid in a sample, comprising: (i) amplifying a nucleic acid sequence comprising a fragment of SEQ ID NO: 1 (Mg219 gene); and (ii) detecting said amplified nucleic acid sequence.