baber/WOPTO huggingface dataset:
Patent DE-69331144-D1 (DE)
Inventor: ROOP DENNIS R
IPC: A61K31/70
Filed: 1993-04-28
Granted: 2001-12-20
Abstract: The keratin K1 vector for expression of a nucleic acid cassette in the epidermis. The vector has a 5' flanking region of the keratin K1 gene including a 5' flanking sequence, a keratin K1 promoter, 5' transcribed but untranslated region and a first intron and an intron/exon boundary, all in sequential and positional relationship for expression of a nucleic acid cassette. A 3' flanking region in the K1 keratin gene containing regulatory sequences including a 3' transcribed but untranslated region and contiguous noncoding DNA containing the transcriptional termination region. The 3' flanking region and a 5' flanking region are linked by a polylinker having a plurality of restriction endonuclease sites for the insertion of a nucleic acid cassette. The nucleic acid cassette encodes a sequence which can be used to express any protein, polypeptide or antisense RNA. The vector can be inserted both in vivo and ex vivo into epidermal cells. Further, it can be used for making transgenic animals or bioreactors of epidermal cells. The vector has been found useful for gene therapy in treatment of a variety of diseases including skin ulcers, wound healing, surgical incisions, psoriasis and cancer.
Patent DE-69402058-D1 (DE)
Inventor: CRESPO ANDRE
IPC: A61P9/08
Filed: 1994-04-01
Granted: 1997-04-17
Abstract: PCT No. PCT/FR94/00371 Sec. 371 Date Jun. 7, 1995 Sec. 102(e) Date Jun. 7, 1995 PCT Filed Apr. 1, 1994 PCT Pub. No. WO94/22822 PCT Pub. Date Oct. 13, 1994This invention relates to perhydroisoindole derivatives of 08/448,402 formula (I), wherein radicals R are phenyl radicals optionally 2-or 3-substituted by a halogen atom or a methyl radical; R1 is optionally substituted phenyl, cyclohexadienyl, naphthyl, indenyl or optionally substituted heterocyclyl; R2 is H, halogen, OH, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, alkoxy, alkylthio, acyloxy, acyloxy, carboxy, optionally substituted alkyloxycarbonyl, benzyloxycarbonyl, amino or acylamino; and R3 is optionally 2-substituted phenyl; optionally salts thereof where applicable; and preparation thereof. Said derivatives are particularly useful as neurokinin A antagonists.    <IMAGE>  (I)
Patent DE-69407847-D1 (DE)
Inventor: EDMONDSON JAMES GEORGE
IPC: C10G9/16
Filed: 1994-02-10
Granted: 1998-02-19
Abstract: Corrosion of the internal metal surfaces of equipment used in the processing of crude oil at 400-790 deg.F is inhibited by adding to the oil a compsn. (I) comprising (a) a trialkyl phosphate containing a 1-12C moiety; and (b) an alkaline earth metal phosphonate-phenate sulphide in which 20-40% of the phenol hydroxy groups have been phosphonated. Wt. ratio (a):(b) is pref. 1:10 to 2:1, esp. 1:5 to 1:1. (a) pref. is tributyl phosphate, (a') and (b) is calcium phisphonate-phenate sulphide pref. (b'). (I) is added at 1-5000, esp. 100-1500 ppm to the crude oil.
Patent DE-69410764-D1 (DE)
Inventor: BROTZMANN KARL PROF DR ING DR
IPC: C21C5/00
Filed: 1994-11-29
Granted: 1998-07-09
Abstract: A process for the production of iron from ferrous raw materials in a converter containing an initial iron smelt into which at least fuels, oxygenous gases and ferrous raw materials are introduced during the production phase, the reaction gases being afterburned with oxidizing gases in the gas space of the converter above the smelt and the resulting heat transferred to the iron bath, and a partial amount of iron smelt being tapped after the production phase and a next initial iron smelt remaining in the converter for the next production phase, wherein the weight of the initial iron smelt is between 10 % and 60 % , based on the weigth of the iron smelt present in the converter after the production phase and before the partial amount is tapped, and the ferrous raw materials are fed continuously to the iron smelt through the gas space of the converter during the production phase while at the same time oxygenous gases containing no more than 50 % oxygen are blown continuously onto the surface of the smelt. <IMAGE>
Patent DE-69414768-D1 (DE)
Inventor: MONACELLI UMBERTO
IPC: B25C5/16
Filed: 1994-07-12
Granted: 1999-01-07
Abstract: The fastener driving tool, comprises a nose assembly including a fixed back plate and a front plate, which is suspended to rotate from a closed, operative position to an open position. The back plate and the front plate when disposed in its closed, operative position, define a drive track through which fastener scan be driven into a workpiece. The back plate is attached to a housing adapted to contain a powered fastener driving mechanism. A magazine assembly for storing and feeding fasteners into the drive track is attached to the back plate. The pivotal connection between the front and back plates is to one side of the drive track. When the front plate is rotated to its open position, the drive track becomes accessible to provide ready access to any jammed fasteners. The surface of the front plate that abuts the back plate is flat to permit the front door to be pivoted to its open position even when the fasteners or the driver is in the drive track. Since any forces created by the fastener or driver during a malfunction is directed perpendicular to the movement of the front plate. The front plate will not unintentionally open during operation.
Patent DE-69415706-D1 (DE)
Inventor: ELLINGBOE JOHN WATSON
IPC: A61P9/12
Filed: 1994-03-16
Granted: 1999-02-18
Abstract: This invention relates to intermediates useful in the production of substituted pyridopyrimidinones of general formula (I): <CHEM>  wherein     n is 0 to 3; R<1> and R<2> are, independently, H, C1-C6alkyl, hydroxy(C1-C6alkyl), formyl, carbonyl(C1-C6alkyl), carboxy, or carboxy(C1-C6alkyl);   R<3> and R<4> are, independently, H, C1-C6alkyl, or hydroxy; R<3a> and R<4a> are H, or one of -CR<3>R<3a> and -CR<4>R<4a> is a carbonyl group; with the proviso that at least one of the groups R<1> and R<2> must be hydroxy(C1-C6alkyl), formyl, carbonyl(C1-C6alkyl), carboxy, or carboxy(C1-C6alkyl); or one of R<3> and R<4> must be hydroxy; or one of -CR<3>R<3a> and -CR<4>R<4a> must be a carbonyl group; ;   Ar<1> is <CHEM>     wherein W is H, C1-C6alkyl, halogen, hydroxy, or C1-C6alkoxy;   Ar<2> is <CHEM>     wherein X is <CHEM> wherein R<5> is H, CH3, tert-butyl, tri-n-butylstannyl, or triphenylmethyl; or a tautomer of said compound,  or a pharmaceutically acceptable salt of said compound or tautomer. The compounds of Formula I are useful for treating hypertension and congestive heart failure. Also disclosed are pharmaceutical compositions containing compounds of Formula I and a pharmaceutically acceptable carrier and methods for production of the compounds of Formula I. Intermediates for making the pharmaceutical useful compounds are also enclosed.
Patent DE-69416103-D1 (DE)
Inventor: PLIURA DIANA
IPC: C07K1/18
Filed: 1994-09-20
Granted: 1999-03-04
Abstract: The invention relates to the chromatographic purification of hemoglobin. The method for purifying hemoglobin from the raw solution containing the admixture of proteinaceous origin provides for the use of ion-exchange chromatography. The raw solution containing 0.1-20% hemoglobin. At the first stage, anion-exchanging column is used when the admixtures are more acidic than hemoglobin, or cation-exchanging column is used when the admixtures are more alkaline than hemoglobin. The continuous flow of the solution results first in the complete saturation of the column with hemoglobin and the admixtures with high affinity to the column, then the column is overloaded following the substitution of hemoglobin. At the second stage, the ion-exchanger alternative to that used at the first stage is employed. Again, upon the complete saturation and overloading of the column, hemoglobin is substituted.
Patent DE-69421462-D1 (DE)
Inventor: KOLAITIS LEONIDAS
IPC: C11D3/37
Filed: 1994-07-19
Granted: 1999-12-09
Abstract: A particulate foam control agent comprises 1 to 30 parts silicone antifoam, 70 to 99 parts zeolite carrier, 1 to 60% of the antifoam of an organopolysiloxane polyoxyalkylene copolymer, deposited onto the zeolite carrier not later than the antifoam and 1 to 40 parts by weight of a polycarboxylate-type binder or encapsulant. This combination give good release in early stages, storage stability and powder characteristics.
Patent DE-69426596-D1 (DE)
Inventor: SENE CLAUDE
IPC: A61K35/76
Filed: 1994-10-26
Granted: 2001-02-22
Abstract: A method of preparing a viral aerosol from a dilute viral suspension prepared by dissolving a virus in an aqueous solution containing 6-12 g/l of a monovalent cation salt, or 50-100 g/l of a hexose, which is then nebulised with a gas pressure of 0.5-3.5 bars or an ultrasonic frequency of 2-5 MHZ. The resulting aerosol composition is also disclosed.
Patent DE-69433642-D1 (DE)
Inventor: NAHASS R
IPC: H01B1/24
Filed: 1994-03-30
Granted: 2004-04-29
Abstract: A polymeric composition having improved toughness and conductivity comprising carbon fibrils in a polymeric material, wherein each of the carbon fibrils has a longitudinal axis, a portion of the fibrils being in the form of aggregates within which the longitudinal axes of the fibrils have substantially the same relative orientation is disclosed, along with methods of making said polymeric composition.
Patent DE-69506279-D1 (DE)
Inventor: MEYNCKENS JEAN-PIERRE
IPC: C04B35/66
Filed: 1995-11-24
Granted: 1999-01-07
Abstract: PCT No. PCT/BE95/00109 Sec. 371 Date May 27, 1997 Sec. 102(e) Date May 27, 1997 PCT Filed Nov. 24, 1995 PCT Pub. No. WO96/16918 PCT Pub. Date Jun. 6, 1996A process and apparatus for making a ceramic article, especially pipes and tubes of ceramic material such as silicon carbide, in which the article is formed by projecting a ceramic powder mixture comprising refractory particles and combustible particles against a smooth-surface metal former which is heated to a temperature of at least 850 DEG  C. where in the presence of an oxygen-rich gas the combustible particles react exothermically to produce from the refractory particles and the reaction product of the combustible particles a coherent refractory article in the shape of the former.
Patent DE-69507454-D1 (DE)
Inventor: DESCALES BERNARD
IPC: G01N21/35
Filed: 1995-10-04
Granted: 1999-03-04
Abstract: A method of determining or predicting a value Px of a property of a feed X to a steam cracking process or yield of said process, which method comprises measuring the absorption Dix of said material at more than one wavelength in the region 600-2600 nm, comparing the said absorptions or a derivative thereof with absorptions Dim or derivatives thereof at the same wavelength for a number of standards S in a bank for which the said property or yield P is known, and choosing from the bank at least one standard Sm with property Pm said standard having the smallest average value of the absolute difference at each wavelength i between the absorption Dix (or derivative thereof) for the material and the absorption Dim (or derivative thereof) for the standard Sm to obtain Px, with averaging of said properties or yields Pm when more than one standard Sm is chosen.
Patent DE-69508656-D1 (DE)
Inventor: MATSUMOTO MASAHIRO
IPC: A01N43/80
Filed: 1995-06-01
Granted: 1999-05-06
Abstract: 3-Isothiazolone compositions which are stable, free from turbidity, and do not corrode metal storage containers are disclosed. They contain as stabilisers hexamethylenetetramine and 5-bromo-5-nitro-1,3-dioxane.
Patent DE-69508959-D1 (DE)
Inventor: CANNATA VINCENZO
IPC: C07C229/62
Filed: 1995-11-24
Granted: 1999-05-12
Abstract: PCT No. PCT/EP95/04635 Sec. 371 Date May 29, 1997 Sec. 102(e) Date May 29, 1997 PCT Filed Nov. 24, 1995 PCT Pub. No. WO96/16927 PCT Pub. Date Jun. 6, 1996A process for the preparation of 5-amino-2,4,6-triiodoisophthalic acid dichloride by chlorinating 5-amino-2,4,6-triiodoisophthalic acid with thionyl chloride in the presence of a suitable solvent and of a tertiary amine salt or quaternary ammonium salt in a molar ratio from 1;1 to 1;2 with respect to 5-amino-2,4,6-triiodoisophathalic acid is described. 5-amino-2,4,6-triiodoisophthalic acid dichloride is an intermediate useful for the preparation of iodinated contrast agents.
Patent DE-69514341-D1 (DE)
Title: Amidino-derivative als no-synthese-inhibitoren
Inventor: CURRIE G
IPC: C07C257/14
Filed: 1995-03-24
Granted: 2000-02-10
Abstract: There is disclosed amidino derivatives of formula (I), pharmaceutical compositions containing these derivatives, and their use in therapy, in particular their use as nitric oxide synthase inhibitors wherein: X is alkyl, alkenyl, alkynyl, -(CH2)kQ(CH2)l- where k is 2 or 3, l is 1 or 2 and Q is 0, Se SiY2 where Y is alkyl, S(O)z where z is 0, 1 or 2, NR where R is hydrogen or alkyl, or -(CH2)mA(CH2)n- where m is 0, 1 or 2, n is 0, 1 or 2, A is 3 to 6 membered aromatic hydrocarbon radical or 3 to 6 membered heterocyclic radical wherein 1 to 3 hetero atoms are oxygen, sulfur or nitrogen and wherein all said radicals may optionally be substituted by one or more substituents such as alkyl, alkoxy, hydroxy, halogen, nitro, cyano, trifluoroalkyl and amino; R1 may be a bond to X or hydrogen (when Q is Se), hydroxyalkyl, alkyl, alkenyl, alkynyl or haloalkyl and wherein all said radicals may optionally be substituted by one or more substituents such as alkyl, alkoxy, hydroxy, halogen, nitro, cyano, trifluoroalkyl and amino; R2 is alkyl, alkenyl, alkynyl, aromatic hydrocarbon radical, haloalkyl, hydroxylamine or heterocyclic radical wherein 1 to 3 hetero atoms are oxygen, sulfur or nitrogen and wherein all said radicals may optionally be substituted by one or more substituents such as alkyl, alkoxy, hydroxy, halogen, nitro, cyano, trifluoroalkyl and amino; and R3 is amino, alkylamine, amino acid, hydroxy, alkoxy, tetrazole or tetrazoloamine.
Patent DE-69515010-D1 (DE)
Inventor: OUVRARD JACQUES
IPC: B21B3/00
Filed: 1995-12-07
Granted: 2000-03-16
Abstract: A steel strip from which drink cans are to be made, is prepared from a hot-rolled strip of very low carbon steel, which is first cold-rolled, then annealed at 600-700 degrees C, then cold-rolled again with at least two passes to reduce its thickness by at least 35%, pref. 38-47%. Pref. the process is continuous, and the two passes reduce the thickness by at least 25% and 5% respectively. The steel may comprise ≥ 0.006% C, ≥ 0.02% Si, 0.15-0.35% Mn, ≥ 0.015% S, ≥ 0.015% P, ≥ 0.006% N, 0.02-0.06% Al and the rest Fe apart from incidental impurities. The resulting strip has a thickness less than 0.2 mm, pref. less than 0.17 mm, and a bursting strength of at least 600 MPa.
Patent DE-69523294-D1 (DE)
Inventor: BERROCAL RAFAEL
IPC: A23L1/305
Filed: 1995-06-16
Granted: 2001-11-22
Abstract: Micellar fluorinated casein is new.
Patent DE-69524199-D1 (DE)
Inventor: SILLEKENS THEODORUS
IPC: C12N15/09
Filed: 1995-08-18
Granted: 2002-01-10
Abstract: The present invention relates to a method for the diagnosis of symptomatic CMV disease, characterized in that the presence of mRNA encoding a late structural protein of the human Cytomegalovirus in a blood sample of an individual, suspected of carrying said disease, is detected, said method comprising the following steps: amplifying a target sequence within said mRNA using a primer pair capable of specifically reacting with said target sequence and suitable amplification reagents, reacting the sample, optionally containing amplified nucleic acid, with a labeled nucleic acid probe having a sequence complementary to part of the target sequence, detecting hybrids formed between the target sequence and the probe. The present invention further provides primers and probes for the amplification and detection of late pp67 HCMV mRNA.
Patent DE-69528893-D1 (DE)
Inventor: HUFFMAN GARY A
IPC: C07K14/415
Filed: 1995-04-20
Granted: 2003-01-02
Abstract: A novel DNA regulatory element that confers anther tapetum-specific gene expression has been discovered, isolated, and characterized. The tapetum-specific regulatory element can be used to control the expression of a foreign gene that disrupts the function of tapetal cells. Thus, the control of maize pollen production can be achieved by using the tapetum-specific regulatory element to produce male-sterile plants. Various methods can be used to restore male fertility in the F1 generation of such male-sterile plants.
Patent DE-69529604-D1 (DE)
Inventor: LUNDBERG PETER
IPC: G01N33/34
Filed: 1995-11-22
Granted: 2003-03-20
Abstract: PCT No. PCT/SE95/01395 Sec. 371 Date Jun. 27, 1996 Sec. 102(e) Date Jun. 27, 1996 PCT Filed Nov. 22, 1995 PCT Pub. No. WO96/16322 PCT Pub. Date May 30, 1996The invention relates to concentration measurement transmitters, more specifically to an arrangement for a static, blade-type transmitter, which includes a blade active in the medium to be measured and suspended by a spindle such that shear force moment at the blade is translated via the spindle to a measurement converter for determining fiber concentration in the medium, the converter preferably being situated in the transmitter housing, into which the spindle extends and is sealed against it with the aid of a lead-through. The latter includes a tube either integral with, or rigidly, cohesively fixed to it and extending downwards to the free end portion of the spindle carrying the blade, the spindle extending through the tube with a clearance enabling movement of the spindle necessary for the measurement converter for a turning movement of the spindle about a theoretical turning center substantially at the middle portion of the tube, to the free end portion of which tube the spindle is rigidly and sealingly fixed, whereby a seal in the lead-through is obtained across the clearance formed between the spindle and the tube, which does not affect the shear force moment translated to the converter and consequently not measurement accuracy either in terms of pressure sensitivity, temperature sensitivity and/or longitudinal forces prone to being transmitted along the spindle towards the measurement converter.
Patent DE-69535252-D1 (DE)
Inventor: SUGIYAMA KOICHI
IPC: H04N5/913
Filed: 1995-12-20
Granted: 2006-11-16
Abstract: Copying, dubbing or reproducing copyrighted digital data can be inhibited or restricted to properly protect a copyright. AV data recorded on a pre-recorded tape is output from a reproducing unit of a first digital VCR with protective information indicating whether the copy of the AV data is inhibited or not. The protective information is input with the A/V data to a second digital VCR. Copy permission information of a blank tape loaded in the second digital VCR is discriminated and the second digital VCR records the AV data supplied from the first digital VCR based on the protective information and the copy permission information.
Patent DE-69535657-D1 (DE)
Inventor: ARDAUD PIERRE
IPC: C09D175/04
Filed: 1995-04-26
Granted: 2008-01-10
Abstract: Masked polyisocyanate is obtained by polycondensation of a isocyanate with an aromatic derivative which is hydroxylated on the ring and which has a group with a function selected from carboxylic acids and nitriles. The polyisocyanate has an (apparent) melting point of at least 30 degrees C and a Tg of at least 10 degrees C. Independent claims are also included for method for synthesizing masked (poly)isocyanate as claimed; and powder composition containing at least one said polyisocyanate.
Patent DE-69608254-D1 (DE)
Inventor: PERDOMI GIANNI
IPC: C08L23/14
Filed: 1996-12-13
Granted: 2000-06-15
Abstract: "HEAT-SHRINKABLE FILMS BASED ON POLYOLEFIN COMPOSITIONS COMPRISING: (I) A LINEAR COPOLYMER OF ETHYLENE WITH ONE OR MORE alpha-OLEFINS (LLDPE); (II) A COPOLYMER OF PROPYLENE HAVING A PARTICULAR COMPOSITION AND CHARACTERISTICS. THE FILMS ARE CHARACTERIZED BY GOOD OPTICAL AND MECHANICAL PROPERTIES, IN PARTICULAR A HIGH TEAR RESISTANCE."
Patent DE-69617814-D1 (DE)
Inventor: HEDBERG SOEREN
IPC: B01D53/64
Filed: 1996-07-05
Granted: 2002-01-24
Abstract: In a method for purification of flue gases from a combustion installation the flue gases are first sucked from the installation and through a liquid, and are then pressed through a liquid, whereby the purified flue gases are fed out into the surroundings. During the transfer the flue gases are split up into as small units as possible in order to provide the best possible contact with the fluid. The method is carried out by means of a flue gas purifier (5) comprising a container (6), which contains a fluid, preferably water, and which is partitioned into chambers (18 - 24). One set of chambers (18 - 21) forms a suction compartment (A) and another set of chambers (22 - 24) forms a pressure compartment (B). Walls (12, 14, 16) forming partitions between the chambers force the flue gases to alternately pass through the fluid and above the fluid. A pump (26) sucks the flue gases through the suction compartment (A) and presses these through the pressure compartment (B). The walls (12, 14, 16) are at least partly provided with slits, through which the flue gases are made to pass thereby being subdivided into a plurality of flows, and the outlet (28) of the pump (26) ends in a spray nozzle immersed in the fluid. The first chamber (18) in the suction compartment (A) in the flow direction of the flue gases is provided with an inlet (25) for the flue gases from the installation, and the last chamber in the pressure compartment (B) is provided with an outlet (29) for purified flue gases. <IMAGE>
Patent DE-69621133-D1 (DE)
Inventor: KLITMOSE PETER
IPC: A61M5/315
Filed: 1996-06-03
Granted: 2002-06-13
Abstract: PCT No. PCT/DK96/00236 Sec. 371 Date Dec. 2, 1997 Sec. 102(e) Date Dec. 2, 1997 PCT Filed Jun. 3, 1996 PCT Pub. No. WO96/38190 PCT Pub. Date Dec. 5, 1996A syringe for injection of doses of a medicine from an exchangeable cartridge has a housing comprising a cartridge holder and a dosing mechanism by which a dose is set and injected by successively advancing a piston rod to press a piston into the cartridge. The dosing mechanism comprises a threaded spindle and a nut member cooperating with the spindle. A dose is set by relative rotation of the spindle and nut member whereby the nut member is moved along the spindle. The position of the nut member on the spindle defines how far the piston rod is advanced. The spindle and the nut are locked against relative rotation when the dosing mechanism is not operated to set a dose. Access to the cartridge holder is obtained by opening a lid connected to the housing and coupled to the dosing mechanism in such a way that the locking of the nut element in its position on the spindle is released when the lid is opened, and the opening movement of the lid is transmitted to a piston rod retraction mechanism.
Patent DE-69632630-D1 (DE)
Inventor: KAUPPINEN SAKARI
IPC: C07H21/04
Filed: 1996-03-15
Granted: 2004-07-08
Abstract: The present invention relates to an enzyme exhibiting aminopeptidase activity, a method for producing said enzyme, an enzyme preparation containing said enzyme exhibiting aminopeptidase activity, and use of said enzyme for various industrial purposes.