baber/WOPTO huggingface dataset:
Patent JP-H09508589-A (JP)
IPC: B28D1/12
Filed: 1995-02-28
Abstract: The present invention is related to an abrasive tool comprising a core and abrasive segments attached to said core wherein said abrasive segments comprise a bond material and superabrasive grains and wherein said segments comprise at least two circumferentially spaced regions and wherein said superabrasive grains are alternately dispersed in said regions in high and low concentrations of superabrasive grains. The present invention is further related to an abrasive tool comprising a core and abrasive segments attached to said core wherein said abrasive segments comprise a bond material and superabrasive grains, wherein said abrasive segments comprise at least two circumferentially spaced regions and wherein said superabrasive grains are alternately dispersed in every other region.
Patent JP-2000504647-A (JP)
IPC: B41J2/18
Filed: 1997-02-20
Abstract: An ink jet printing system comprising: a tank (3 or 15) for holding a liquid for use in the operation of said system; a multi-level (201 or 203) or continuous level sensor for measuring the rate of change of liquid level in said tank (3 or 15) during said operation, said multi-level sensor (201 or 203) comprising at least three level sensors each of which detects whether liquid height is above or below the level at which it is located, said continuous level sensor comprising a sensor which continuously provides measurement of liquid level; and means (21) for using said measurement of the rate of change of liquid level in said tank (3 or 15) to provide an indication that there has been a fault in said system.
Patent JP-H11504262-A (JP)
Title: 廃流処理
IPC: A62D101/20
Filed: 1997-02-12
Abstract: (57)【要約】
有機ホウ素化合物の水溶液を１５０℃を超える温度、蒸発を防ぐのに十分な圧力およびｐＨ５以上９以下での処理によりホウ酸および相応する有機化合物に加水分解する廃水の浄化方法。
Patent JP-H10500793-A (JP)
Title: 固定ブロック内における可変長レコードのパッキング
IPC: G06F3/06
Filed: 1995-05-23
Abstract: (57)【要約】
可変サイズのユーザデータレコード（４４）を記憶媒体上の固定サイズの物理的ブロック（３８）にパッキングするためのシステムである。この発明は、エラー検出および訂正情報（４６）とともに可変サイズのユーザデータレコード（４４）を受取り、かつ各レコード（４４）にデータページを作成する。レコードパッキング情報のマップエントリ（５２）が各レコードデータページ（４４）に作成される。マップエントリ（５２）はレコードページ（４４）の場所を含み、かつレコードページ（４４）に含まれるレコードのタイプ、サイズおよび圧縮状態といったさらなる情報を含んでもよい。データページはマップエントリ（５２）と同じ物理的ブロック（３８）に記憶される。物理的構成は、エンティティ（７０）上の論理的ブロック（７２）からなる構成上に記憶される。
Patent JP-H11509517-A (JP)
IPC: A61P3/00
Filed: 1996-07-11
Abstract: Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents.
Patent JP-2001512420-A (JP)
Title: 乳幼児に授乳するための方法と瓶
IPC: A61J9/00
Filed: 1998-01-05
Abstract: (57)【要約】
食事量全体の容積の30％〜60％であり、2.5〜3.5％の脂肪を有する初期乳相当のものを乳幼児に与える段階、および（b）食事量全体の容積の40％〜70％であり、3.7〜5.5％の脂肪を有する後期乳相当のものを乳幼児に与える段階から成る、人間以外の乳を与える方法。
Patent JP-2000509589-A (JP)
Title: ディジタル化画像の符号化および復号化のための、方法および装置
IPC: H04N19/122
Filed: 1998-01-07
Abstract: (57)【要約】
イントラ画像符号化とインター画像符号化とでは異なるフォームマッチング変換符号化が行われる、フォームマッチング変換符号化法が提供される。第１のフォームマッチング変換符号化がイントラ画像符号化において行われ、第１のフォームマッチング変換符号化とは異なる第２のフォームマッチング変換符号化がインター画像符号化で行われる。
Patent JP-H11505277-A (JP)
Title: 漂白触媒としてのｎ−ベンジルイミニウム塩
IPC: C11D3/39
Filed: 1996-04-23
Abstract: (57)【要約】
特に、織物洗剤−漂白系における漂白触媒としての、式中、Ｒ 1 及びＲ 2 は、相互に無関係で、水素又は場合により置換されたアルキル、アルケニル、アルアルキル、ヘテロアルアルキル、アリール又はヘテロアリールを表わし、この際、基Ｒ 1 又はＲ 2 の少なくとも１方は、脂肪族基においては、少なくとも５個のＣ−原子を有し、又は環状基においては、少なくとも７個のＣ−原子を有するという条件を有し、Ｒ 3 は、有機又は無機の置換基を表わし、ｍは１、２又は３を表わし
 こで、ｎは、陰イオンＸのイオン価を表わすＮ−ベンジルイミニウム塩（Ｉ）の使用。
Patent JP-H11506026-A (JP)
IPC: G01N33/569
Filed: 1997-03-21
Abstract: A monoclonal or polyclonal antibody specific for an epitope common to Staphylococcus aureus strains of various capsular serotypes, particularly methicillin-resistant strains, the antibody being selected from immunoglobulins G, M, and A, and the use thereof in a reagent for detecting Staphylococcus aureus.
Patent JP-2000506923-A (JP)
IPC: C08L33/00
Filed: 1997-03-14
Abstract: PCT No. PCT/GB97/00723 Sec. 371 Date May 29, 1997 Sec. 102(e) Date May 29, 1997 PCT Filed Mar. 14, 1997 PCT Pub. No. WO97/34945 PCT Pub. Date Sep. 25, 1997Primary polymer particles having a size at least 90% below 10  mu m and which contain water soluble and water insoluble polymer are made by reverse phase polymerisation of a water soluble ethylenically unsaturated monomer or monomer blend with cross linking agent, and the emulsion is then spray dried to form spray dried granules which disintegrate upon addition to water, thereby forming an aqueous composition of the insoluble particles having activity similar to the starting emulsion. This aqueous composition of insoluble particles is particularly useful for flocculation, for instance flocculation of sewage sludge followed by centrifugation or belt pressing, or for viscosification.
Patent JP-2000508642-A (JP)
IPC: C07C217/28
Filed: 1997-04-08
Abstract: Cationic lipids, having a derivatized quaternary ammonium head group, that provide improved cell targeting ability and enhanced transfective efficacy for the delivery of molecules into cells. The lipids comprise a linker having functional groups that provide sites for further attachment of drugs, cell receptor ligands or other bioactive agents.
Patent JP-2001515662-A (JP)
IPC: H01L21/8238
Filed: 1998-12-07
Abstract: SOI-IGBT with a first conductive type channel area (13), at least one second conductive type cell area (10) and at least one first conductive type intermediate area (15) defining the IGBT. The channel area (13), cell area (10) and intermediate area (15) are arranged in an insulating layer (5) on a first conductive type semi-conductor body (1). The channel area (13), cell area (10) and intermediate area (15) are connected to the semiconductor body (1) by means of recesses (6, 7, 8) in the insulating layer (5).
Patent JP-2000510322-A (JP)
Title: カルシウムペクチンを使用する、バッターでころもをつけそしてパン粉をまぶした食品組成物
IPC: A23L5/10
Filed: 1996-05-30
Abstract: (57)【要約】
煮たったたっぷりとしたあぶらで揚げている間に油を吸収することに抵抗する、バッターでころもをつけパン粉をまぶした食品組成物の製造方法および組成物。パン粉をまぶした組成物は、カルシウムでパン粉配合物のカルシウム含量を高くすることにより調製する。これは、乾燥ブレンド、噴霧乾燥もしくは凝集のいずれか（噴霧被覆または続いて乾燥させる）、カルシウム源をパンくず中に焼くことにより含有させるまたは上述の任意の組み合わせにより達成される。次いで、バッターによりころもをつけパン粉をまぶした食品組成物をカルシウム反応性ペクチンで処理する。カルシウム−ペクチン被覆は、揚げ用油の吸収および吸着を顕著に防ぎ、食品組成物の水分、カリっとした感触および加熱用ランプに対して安定性を増加させるよう作用する。または、食品を最初カルシウム反応性ペクチンで処理し、次いで、使用の状況に依存して、カルシウム源で処理する。
Patent JP-2001514745-A (JP)
IPC: G01N30/88
Filed: 1998-03-04
Abstract: A matrix is disclosed including a core showing a system of micropores and a surface in which the micropore system has openings. The characterizing feature is that the surface is coated with a polymer (I) having such a large molecular weight that it cannot penetrate into the micropores.
Patent JP-2002503119-A (JP)
IPC: A61B17/32
Filed: 1997-05-16
Abstract: A sample of a body fluid such as blood or interstitial fluid is obtained from a body by glancing a portion of a user's skin, preferably in an area other than a finger tip to form an incision. After the needle (42) has been removed from the incision, a force is applied to depress the skin in a manner forming a ring of depressed body tissue in surrounding relationship to the incision, causing the incision to bulge and the sides of the incision to open, whereby body fluid is forced out through the opening of the incision. A stimulator member (64) is mounted to an end of a lancet carrying housing (40) for applying the force. The stimulator member (64) can be movable relative to the housing, and can be either heated or vibrated to promote movement of the body fluid
Patent JP-2001521525-A (JP)
Title: 歯表面処置組成物および歯表面処置法
IPC: A61K6/00
Filed: 1998-04-13
Abstract: (57)【要約】
歯表面処置組成物は、それを歯表面に塗り、次いで洗浄しないときに、組成物が歯構造の接着性を増すような、水溶液中の少なくとも１種の水溶性酸である酸性成分を含有する。歯構造の処置法は、歯構造を前記組成物と接触させることを含む。
Patent JP-2002503162-A (JP)
IPC: B29C65/34
Filed: 1998-05-15
Abstract: A fusion joining apparatus includes an electrical power source, a first frequency converter coupled to the electrical power source, a connector for connection to an induction fusion heater, a second frequency converter and a controller. During operation, the electrical power source generates source electrical power at a source voltage and a source frequency. The first frequency converter steps up the voltage and the frequency of the source electrical power to produce high voltage electrical power. The second frequency converter reduces the voltage and frequency of the high voltage electrical power and produces low voltage electrical power. The second frequency converter has terminals for connection to a resistance fusion heater to provide the low voltage electrical power to the resistance fusion heater. The controller includes a processor which selects one of the second frequency converter and the connector and a switch to direct the high voltage electrical power to the selected one of the second frequency converter and the connector.
Patent JP-2002500649-A (JP)
IPC: C07K7/06
Filed: 1998-05-20
Abstract: Disclosed are peptides which are peptide derivatives of the HJ loop of a serine/threonine kinase. The peptides can modulate the activity of the serine/threonine kinase. Also disclosed are methods of modulating the activity of a serine/threonine kinase in a subject by administering one of the peptides of the present invention.
Patent JP-H06322463-A (JP)
Title: Gamma titanium - aluminum alloy modified by chromium and tungsten and its preparation
Inventor: SHII-CHIN FUAN
IPC: B22F3/15
Filed: 1990-08-07
Abstract: PURPOSE: To obtain a γ-Ti-Al alloy excellent in ductility, strength, working aptitude, oxidation resistance or the like by specifying the compsn. composed of Ti, Al, Cr and W.  
     CONSTITUTION: This Ti-al alloy is the one composed of, by atomic ratio Ti 52-44 , Al 46-50  Cr 1-3  W 1-3 , and in which the characteristics of a γ-Ti-al intermetallic compd. are improved by Cr and W. The alloy is obtd. by ingot metallurgy, and preferably, heat treatment is furthermore executed at 1,250 to 1,350°C. By reinforcing this ally by a fibrous reinforcing material such as SiC fibers, it is suitably used as the component in the structure for used at high strength and high temps. such as a jet engine or the like. 
     COPYRIGHT: (C)1994,JPO
Patent NZ-205425-A (NZ)
Title: 1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino-(2,1-alpha)isoquinoline derivatives
Inventor: GRIFFITH R C
IPC: C07D471/04
Filed: 1983-08-30
Abstract: Compounds of formula 
<CHEM>
 wherein R1 is hydrogen, alkyl, cycloalkyl, alkanoyl, aralkyl, aralkanoyl, aryl or aroyl and R2 and R3 are the same or independently hydrogen, halogen, hydroxy, acyloxy, nitro, amino, aminoalkyl, trifluoromethyl, alkyl, alkoxy, acyl, cyano, or alkylamino with antidepressant, antihistaminic and cholinergic activity.
Patent NZ-212140-A (NZ)
Title: Magnetic disc digital data transfer to computer
Inventor: KEN KUTARAGI
IPC: G11B20/10
Filed: 1985-05-21
Abstract: A method of recording and/or reproducing digital data on a rotary magnetic disc (2) under the condition that address data of the digital data are made non-consecutive relative to an original time sequence thereof by adding error correction bits to the digital data and re-arrangement of the digital data, includes providing a buffer memory (20) between the disc (2) and a peripheral device, the buffer memory (20) having a capacity capable of completing the re-arrangement of the digital data, allocating the digital data to the buffer memory (20) such that actual data and the error correction bits are respectively stored in different memory areas of said buffer memory (20), and converting address data upon writing or reading the digital data from the buffer memory (20) so as to allocate the address data such that the address data become non-consecutive as seen from a recorded pattern of the disc (2) and consecutive as seen from the peripheral device.
Patent NZ-217959-A (NZ)
Title: Imidazoquinazoline derivatives and pharmaceutical compositions
Inventor: WAETJEN FRANK
IPC: A61P25/18
Filed: 1986-10-16
Abstract: New heterocyclic compounds having the general formula <CHEM>  wherein <CHEM>  wherein R' is C1-6-alkyl, C3-7-cycloalkyl, or C3-7-cycloalkylmethyl, R<6> and R<7> independently are hydrogen, halogen, alkoxy or trifluoromethyl , and  R'' is hydrogen, C1-6-alkyl, or C3-7-cycloalkyl The compounds are useful in psychopharmaceutical preparations as anticonvulsants, anxiolytics, hypnotics, and nootropics.
Patent NZ-221027-A (NZ)
Title: Diphosphonic acid derivatives and pharmaceutical compositions
Inventor: GALL RUDI
IPC: C07F9/38
Filed: 1987-07-10
Abstract: The present invention provides disphosphonates of the general formula:   <IMAGE> (I)  wherein R1 is a straight-chain or branched, saturated or unsaturated aliphatic hydrocarbon radical of 1-9 carbon atoms which is optionally substituted by phenyl or cyclohexyl, R2 is cyclohexyl or cyclohexylmethyl, benzyl or a straight-chained or branched, saturated or unsaturated aliphatic hydrocarbon of 4 to 18 carbon atoms which is optionally substituted by phenyl or oxygen wherein the oxygen can be esterified or etherified, R3 is hydrogen or a straight-chain or branched alkyl of 1-4 carbon atoms, X is a straight-chain or branched alkylene chain of 1-6 carbon atoms and Y is hydrogen, hydroxyl or an amino group optionally substituted by alkyl radicals of 1-6 carbon atoms; as well as the pharmacologically acceptable salts thereof. The present invention also provides processes for the preparation of these diphosphonic acid derivatives and pharmaceutical compositions containing them for the prophyllaxis treatment of diseases or disturbances of calcium metabolism such as osteoporsis, Pagets disease, Bechterew's disease, bone metastases, urolithiasis, heterotropic ossifications, rheumatoid arthritis, osteoarthritis and degenerative arthrosis.
Patent NZ-222813-A (NZ)
Title: Urea and thiourea heterocyclic compounds and herbicidal compositions
Inventor: LIANG PAUL HSIAO-TSENG
IPC: A01N47/36
Filed: 1987-12-04
Abstract: Pyridinesulfonylureas of general formula: <CHEM>  wherein J is a substituted pyridyl group;  W is O or S;  R is H or CH3; A is a mono- or bicyclic heterocyclic group, e.g. pyrimidinyl or triazinyl; and their agriculturally suitable salts show high activity as preemergence and postemergence herbicides. some also show a plant growth regulant effect. The novel compounds may be made e.g. by reacting an appropriate pyridine sulfonamide JSO2NH2 with an appropriate heterocyclic phenyl carbamate:- <CHEM> t
Patent NZ-234453-A (NZ)
Title: Recombinant dna encoding urate oxidase, and vector, host, protein and pharmaceutical compositions associated therewith
Inventor: CAPUT DANIEL
IPC: C12N15/85
Filed: 1990-07-11
Abstract: The invention concerns a new urate oxidase activity protein which has the sequence (I), possibly preceeded by a methionine, or in that it may present a degree of substantial homology with this sequence. The invention is also aimed at medicines containing this protein, as well as the genetic engineering implements to obtain it.
Patent NZ-235570-A (NZ)
Title: Article carrier; cutout in end panel flap terminates at a point spaced from the side panel
Inventor: SCHUSTER RICHARD LEE
IPC: B65D5/02
Filed: 1990-10-04
Abstract: An enclosed article carrier having upper sloping and panels to conform to the shape of the end articles in the carrier. The end panels are comprised of dust flaps adhered to overlapping upper and lower end flaps. Each dust flap is connected to the adjacent edge of its side panel along angled fold lines, the bottom edge of the dust flap being connected to the side panel adjacent the bottom panel of the carrier. Each dust flap has a cutout extending from its outer edge to a point spaced from the juncture of the fold lines. The carriers are thus strong enough to resist bowing during loading, resulting in well-aligned end panel flaps.
Patent NZ-250323-A (NZ)
Title: Recliner chair assist apparatus having manual actuator and brackets connected to drive rod for over centering action
Inventor: LAPOINTE LARRY PATRICK
IPC: A47C1/0355
Filed: 1993-11-30
Abstract: A reclining modular seating section having a recliner assist apparatus for initiating reclining movement of the seating section and extending movement of a leg rest assembly thereof. The release assist apparatus includes an insert member (346) fixedly secured to a drive rod (324) of a recliner mechanism of the seating unit. A drive bracket (326) is fixedly secured to the insert member (346) and pivotally coupled to an L-shaped coupling bracket (328). The L-shaped coupling bracket (328) is in turn coupled to a biasing spring (330) which exerts a tensioning force to drive the drive bracket (326) and drive rod (324), to thereby cause the seating section to assume a reclined position with its leg rest member in an extended position when the drive bracket reaches an over center position. A release assist bracket (322) is disposed coaxially about the insert member (346) and has an end thereof coupled to a handle member (316) which is graspable by an occupant of the seating unit. By pulling on the handle member (316), the release assist bracket (322) urges the drive bracket (326) to an over center position, thereby enabling the biasing (330) spring to continue driving the drive rod (324) so as to extend a leg rest assembly and simultaneously recline a seatback portion of the seating unit. <IMAGE>
Patent NZ-258561-A (NZ)
Title: Heat storage medium for a latent heat (cold) accumulator which solidifies by forming crystals the structure of which is modified by an additive such as hollow cones accumulator
Inventor: HILDEBRAND GUENTER DR ING
IPC: F28D20/02
Filed: 1993-11-29
Abstract: The invention relates to a heat storage medium which forms crystal structures on congealing, like paraffin, for a latent heat store (latent cold store). In order in particular to obtain improved response behaviour when heat is supplied, it is proposed according to the invention that the crystal structures be modified by a structure additive, preferably hollow structures, e.g. hollow cones.
Patent NZ-271372-A (NZ)
Title: Use of glutamine synthetase inhibitors, particularly glufosinate, to improve the yield of plants which are resistant to such inhibitors
Inventor: DONN GUNTER
IPC: A01N57/20
Filed: 1994-08-05
Abstract: The invention concerns a method of increasing the yield of crops which are resistant to glutamine synthetase inhibitors, the method calling for crop plants to be treated with small amounts of glutamine synthetase inhibitors. The invention also concerns the use of glutamine synthetase inhibitors to increase the yield of transgenic crop plants.
Patent NZ-297610-A (NZ)
Title: Razor handle formed from body having a flexible outer surface and fins and an inner core formed of a more rigid material
Inventor: APPRILLE DOMENIC V
IPC: B26B21/56
Filed: 1995-10-10
Abstract: A handle assembly for a safety razor comprises a grip portion formed of a pair of shells mounted on a substantially planar body member. The shell members cover only the periphery of the top and bottom surfaces of the body member which is fabricated of a first element formed of a substantially flexible elastomeric material and a second element formed of a more rigid material. The second element is sandwiched between the top and bottom surfaces of the first element, or imbedded within the first element by a molding process.
Patent NZ-313262-A (NZ)
Title: A magnetic filter device
Inventor: HALL HAROLD
IPC: B03C1/033
Filed: 1996-07-24
Abstract: A magnetic filter device for filtering ferromagnetic material from a fluid in which said material is suspended, has a pair of annular plates (5, 6) attached to either side of an annular magnet (2) of smaller diameter. Pairs of pole pieces (11, 12) radially disposed on the plates (5, 6) are aligned so as to generate fields of magnetic flux which promote the collection and retention of ferromagnetic material between the pairs of pole pieces (11, 12).
Patent NZ-329449-A (NZ)
Title: Producing a ceramic superconductor comprising cryogenically deforming and sintering the deformed material
Inventor: DOU SHI XUE
IPC: H01L21/00
Filed: 1997-12-19
Abstract: To produce a high temperature ceramic superconductor, a ceramic superconductor material or a precursor of such material is cryogenically deformed and the deformed material is sintered. Cryogenic deformation means mechanical deformation of the material at lower temperatures rather than the prior art high temperature (~8000C) deformation.  The deformation temperature is preferably -1500C to -2100C.
Patent NZ-333347-A (NZ)
Title: Method of producing encapsidated virion particles containing nucleic acid sequences in yeast
Inventor: PRICE DUANE B
IPC: C07K14/08
Filed: 1997-03-21
Abstract: A method of synthesizing particles containing nucleic acid sequences comprising the steps of introducing a non-endogenous packageable nucleic acid sequence and a sequence encoding a suitable non-endogenous capsid protein into yeast cells and inducing particle assembly, wherein at least one nucleic acid is encapsidated. Preferably, the particle is an infectious virion and the method additionally comprises the step of inducing viral nucleic acid replication before particle assembly. A method of replicating Nodaviridae virus nucleic acid sequences in yeast is also described. Fig. 1A is a schematic drawing of FHV genomic RNA1 and RNA2. Fig. 1B is a schematic drawing of plasmids Yeplac112, PIR, and P1(fs)R. Fig. 1C is a schematic drawing of DU and DUD3'.
Patent NZ-334969-A (NZ)
Title: Cooling system including a liquid flow path from a vat through an apparatus for heat exchange
Inventor: WARD DALE CAMERON
IPC: F28F27/00
Filed: 1997-10-03
Abstract: A cooling system particularly but not exclusively for cooling milk transferred for a milking station to a vat along a first flow path, the system including an apparatus for heat exchange with milk passing therethrough, wherein a second flow path is provided for circulating milk in the vat through the apparatus and the second flow path isolated from the first flow path.
Patent NZ-504300-A (NZ)
Title: A method for directional stable transformation of eukaryotic cells using non-identical recombination sites
Inventor: BASZCZYNSKI CHRISTOPHER L
IPC: C12N15/29
Filed: 1998-11-17
Abstract: A composition and method for introducing nucleotide sequences at preferred genomic target sites in a eukaryotic genome. The composition comprises transfer cassette which are flanked by non-homologous recombination sites. The method involves transforming eukaryotic cells containing target sites utilising non-integrating transformation methods. The method results in efficient integration of nucleotides into predetermined genetic locations and eliminates random DNA integration.
Patent NZ-505970-A (NZ)
Title: Benzothiadiazoles and derivatives and their use for diseases induced by corticotropine releasing factor (CRF)
Inventor: NEUMANN BERNHARD PETER
IPC: C07D239/72
Filed: 1999-02-01
Abstract: The compound of formula I wherein X  is  0, S, N-CH3, CH=CH or CAlk = CAlk, where the Alk  are independently (C1-4)alkyl R1  and R2 are independently hydrogen, halogen, (C1-4)alkyl, (C1-4)alkoxy or trifluoromethyl Het  is a radical having one of the formulae of  (a) to  (p) wherein: R3  and R8 are independently hydrogen or (C1-4)alkyl, R4  is hydrogen,   (C1-4)alkyl,  cyano,  nitro,  formyl   or   (C1- 4)alkylcarbonyl R5  and  R6  are  independently hydrogen, (C1-7)alkyl,  (C3- 7)alkenyl,   (C3-7)cycloalkyl,  (C3-7)cycloalkyl(C1-4)alkyl, (C1-4)alkoxy(C2-5)alkyl or benzyl R7 is hydrogen, hydroxy, (C1-4)alkyl or (C1-4)alkoxy, W  is  N,  C-CN, C-NO2, C-COH or C-CO-Alk: where Alk  is  as defined above X is as defined above in  a free base or acid addition salt form and a process for the preparation of the compound is described. A  pharmaceutical  composition comprising  the  compound  of formula  I  is  useful for the treatment of any  state  with increased level of CRF (corticotropine releasing factor)  or of  a  disease induced or facilitated by CRF or a  state  in which    the   HPA   (hypothalamic   pituitary   axis)    is disregulated.