Patent SG-11201805990X-A (SG)
Title: Means and methods for staging, typing and treating a cancerous disease
Inventor: KLEIN CHRISTOPH
IPC: C12Q1/68
Filed: 2017-01-27
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 3 August 2017 (03.08.2017) WIPO I PCT (10) International Publication Number WO 2017/129753 Al 11111111111111011101111111111101011111011101110111111011111101101111111110111111 (51) International Patent Classification: C12Q 1/68 (2006.01) (21) International Application Number: PCT/EP2017/051789 (22) International Filing Date: 27 January 2017 (27.01.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16152883.1 27 January 2016 (27.01.2016) EP (71) Applicants: FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V. [DE/DE]; Hansastr. 27c, 80686 Miinchen (DE). UNI- VERSITAT REGENSBURG [DE/DE]; Universitasstr. 31, 93053 Regensburg (DE). (72) Inventors: KLEIN, Christoph; Eichenstr. 12a, 93049 Re- gensburg (DE). SCHEITLER, Sebastian; Martin-Gre- if-Str. 1, 93051 Regensburg (DE). WERNER-KLEIN, Melanie; Eichenstr. 12a, 93049 Regensburg (DE). HOFF- MANN, Martin; Alte Nilmberger Str. 30, 93059 Regens- burg (DE). HODAK, Isabelle; Jakob-Hagenbacher-Str. 10c, 80993 Miinchen (DE). = (74) Agent: MEIER, Jurgen; SiebertstraBe 3, 81675 Mlinchen (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) W O 20 17 / 12975 3 Al (54) Title: MEANS AND METHODS FOR STAGING, TYPING AND TREATING A CANCEROUS DISEASE (57) : The present invention relates to methods for diagnosing, staging and treating cancer, in particular melanoma. In par , - ticular, the present invention provides methods for determining the stage/type of a cancerous disease, comprising detecting somatic alterations of the DNA of one or more disseminated cancer cells (DCCs), obtained after homing to a distant organ, such as lymph node; and determining the somatic evolution of the DCC(s) based on the detected somatic alterations, wherein the somatic evolution is indicative of the stage/type of the cancerous disease.