Patent GB-633370-A (GB)
Title: Process for preparing complex organic compounds of antimony
IPC: C07F9/90
Filed: 1947-04-08
Abstract: Complex organic compounds of antimony are formed by mixing a compound of ionizable trivalent antimony in a substantially neutral aqueous medium with 1 : 2-dihydroxy-benzene-3 : 5-disulphonic acid, or a water-soluble salt thereof, in an amount that the end product contains more than 2 mols. but not more than 10 mols. of said acid or its salt for one atom of trivalent antimony, e.g. more than 2 mols. but not more than 3.5 mols.  By compound of ionizable trivalent antimony is meant any compound of trivalent antimony which in aqueous medium, if necessary after acidification, forms antomony ions reacting with hydrogen sulphide to form antimony sulphide.  In examples, the following antimony compounds are reacted with the disodium salt of 1 : 2-dihydroxy - benzene - 3 : 5 - disulphonic acid: sodium antimonyl tartrate, antimony oxide and hydroxide, the products obtained by the reaction of sodium salt of thiosalicylic acid with antimony hydroxide in aqueous solution and of the probable formula Sb­(S-C6H4-COONa)3, antimonyl pyrocatechin malonic acid and antimonyl pyrocatechin levulinic acid formed by reacting antimonyl pyrocatechin with aqueous malonic acid and levulinic acid respectively, neutralized with sodium carbonate, antimonyl gallic acid malonic acid obtained by dissolving malonic acid in water, neutralizing the solution and adding antimonyl gallic acid, antimonyl pyrocatechol thioglycollic acid of the probable formula <FORM:0633370/IV (b)/1> and obtained by reacting a solution of thioglycollic acid and caustic soda in water with antimonyl pyrocatechol, a compound of the probable formula <FORM:0633370/IV (b)/2> and obtained by reacting the potassium salt of pyrogallol-4 : 5-disulphonic in neutral aqueous solution with antimony oxide, antimonyl pyrocatechin tartaric acid sodium salt of the formula <FORM:0633370/IV (b)/3> and obtained by heating aqueous tartaric acid neutralized with sodium carbonate with antimonyl pyrocatechin, a compound of the probable formula <FORM:0633370/IV (b)/4> obtained by reacting in neutral aqueous solution pyrocatechin-3 : 5-disulphonic acid and antimonyl pyrocatechin, potassium antimonyl tartrate, a compound of the probable formula <FORM:0633370/IV (b)/5> and prepared by heating a neutral aqueous solution of 8-hydroxyquinoline disulphonic acid with an excess of antimony trihydroxide, antimonyl gallic levulinic acid obtained by reacting levulinic acid in neutral aqueous solution with antimonyl gallic acid, antimonyl pyrogallol thioglycollic acid obtained by reacting in neutral aqueous solution thioglycollic acid and antimonyl pyrogallol, the complex obtained by dissolving antimonyl pyrocatechin in aqueous sodium citrate, sodium and antimonyl malonate, and potassium antimonyl lactate.  Other suitable salts of the acid are the mono-sodium salt, potassium, lithium, ammonium and calcium salts, and water-soluble organic salts, e.g. the diethylamine or methylglucamine salts.  The Specification as open to inspection under Sect. 91 refers to the use of any trivalent antimony compound for forming the complex antimony compounds.  This subject-matter does not appear in the Specification as accepted.ALSO:Therapeutic antimonyl preparations are obtained by mixing a compound of ionizable trivalent antimony in a substantially neutral aqueous medium with 1 : 2-dihydroxy-benzene-3 : 5-disulphonic acid or a water soluble salt thereof in an amount that the end product contains more than 2 mols but not more than 10 mols of said acid or its salt for one atom of trivalent antimony, e.g., more than 2 mils but less than 3.5 mols.  By compound of ionizable trivalent antimony is meant any compound of trivalent antimony which is an aqueous medium, if necessary after acidification, forms antimony ions reacting with hydrogen sulphide to form antimony sulphide.  Sodium carbonate or bicarbonate, buffer salts such as Na2HPO4 and compounds having a reducing effect such as ascorbic acid may be added to the preparations.  Suitable salts of 1 : 2-dihydroxy-benzene-3 : 5-disulphonic acid are the mono- and di-sodium, potassium, lithium, ammonium, calcium salts and water soluble organic salts such as diethylamine or methylglucamine salts.  A solid mixture comprising the trivalent antimony compound and the 1 : 2-dihydroxybenzene-3 : 5-disulphonic acid or a water soluble salt thereof in an amount that the mixture contains more than 2 mols and not more than 10 mols of said acid or its salt may be prepared and may also contain buffer salts.  A number of examples are given.  The Specification as open to inspection under Sect. 91 refers to the use of any trivalent antimony compound for the above purpose. This subject-matter does not appear in the Specification as accepted.