Patent SG-11201809686S-A (SG)
Title: Yeast vaccine vector including immunostimulatory and antigenic polypeptides and methods of using the same
Inventor: HARGIS BILLY
IPC: A61K39/00
Filed: 2017-05-03
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1#11101111 Organization 011101011M 0101111 1 0 I HIM 01111001111 NH ill OE 1111 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/192671 Al 09 November 2017 (09.11.2017) W I PO I PCT (51) International Patent Classification: tion, TX 77845 (US). BIELKE, Lisa; 1680 Madison A61K 36/06 (2006.01) A61K 39/00 (2006.01) Avenue, 202 Gerlaugh Hall, Wooster, OH 44691 (US). (21) International Application Number: FAULKNER, Olivia, B.; 5410 Melrose Lane, Shawnee, KS 66203 (US). PCT/US2017/030764 (22) International Filing Date: (74) Agent: VANHEYNINGEN, Tambryn K. et al.; Andrus Intellectual Property Law, LLP, 100 East Wisconsin Av- 03 May 2017 (03.05.2017) enue, Suite 1100, Milwaukee, WI 53202 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of national protection available): AE, AG, AL, AM, (30) Priority Data: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 62/331,044 03 May 2016 (03.05.2016) US CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (71) Applicants: THE BOARD OF TRUSTEES OF THE HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, UNIVERSITY OF ARKANSAS [US/US]; 2404 North KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, University Avenue, Little Rock, AR 72207 (US). THE MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, TEXAS A&M UNIVERSITY SYSTEM [US/US]; 3369 PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, Tamu, College Station, TX 77843-3369 (US). SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventors: HARGIS, Billy; 3811 Monte Vallo Manor, — Fayetteville, AR 72764 (US). CALHOUN, Leona, Nicole; (84) Designated States (unless otherwise indicated, for every 3658 N. Hayfield Circle, Fayetteville, AR 72704 (US). kind of regional protection available): ARIPO (BW, GH, BERGHMAN, Luc; 1207 Martinsville Lane, College Sta- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = (54) Title: YEAST VACCINE VECTOR INCLUDING IMMUNOSTIMULATORY AND ANTIGENIC POLYPEPTIDES AND OF USING THE SAME METHODS = = Figure 1 = 735: = = 730 , = = — — : C I 725 = on ‘ = 0 --- T 1 = _ 7, 720 c a E SE = a) .., c — a) a SE-AgA-CD154 IN SE-AgA-AgB-HMG B1 — _ = , e 715 V ,., _ 3 ' 710 •- 7 11 a 705 t- 11 IN ---A V::+ ei 700 ,, aa C:r 11 (57) : Vaccine compositions including a yeast comprising an immunostimulatory polypeptide and optionally an antigenic 0 polypeptide are provided herein. The immunostimulatory polypeptide and the antigenic polypeptide are expressed or displayed on the N surface of the yeast vaccine composition. Methods of using the vaccine composition to vaccinate subjects are also provided. C [Continued on next page] WO 2017/192671 Al IMEDIMOM0101011MMEMOMOICEEHINifilinilliill UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))