baber/WOPTO huggingface dataset:
Patent CA-3091076-A1 (CA)
Title: 2,4-diaminoquinazoline derivatives and medical uses thereof
Inventor: MC GOWAN DAVID CRAIG
IPC: A61P31/12
Filed: 2019-02-28
Abstract: This application relates to quinazoline derivatives of formula (I), pharmaceutical compositions comprising the compounds of formula (I), and the use of the compounds of formula (I) in the treatment or prevention of a viral infection, of a virus-induced disease, of cancer or of an allergy. In formula (I), R1 is a C3-8alkyl, optionally substituted by one or more substituents independently selected from fluorine, hydroxyl, amino, nitrile, ester, amide, C1-3 alkyl, or C1-3 alkoxy, the carbon of R1 bonded to the amine in the 4-position of the quinazoline is in (R)-configuration, R2 is hydrogen, deuterium, fluorine, chlorine, methyl, methoxy, cyclopropyl, trifluoromethyl, or carboxylic amide, wherein each of methyl, methoxy and cyclopropyl is optionally substituted by one or more substituents independently selected from fluorine and nitrile, R3 is hydrogen or deuterium, R4 is hydrogen, deuterium, fluorine, methyl, carboxylic ester, carboxylic amide, nitrile, cyclopropyl, C4-7 heterocycle, or 5-membered heteroaryl group, wherein each of methyl, cyclopropyl, C4-7 heterocycle and 5-membered heteroaryl group is optionally substituted by one or more substituents independently selected from fluorine, hydroxyl, or methyl, R5 is hydrogen, deuterium, fluorine, chlorine, methyl, or methoxy, provided that at least one of R2, R3, R4 and R5 is not hydrogen.
Patent CA-3092405-A1 (CA)
Title: Device and method for fractional rf treatment of the skin
Inventor: VAYNBERG BORIS
IPC: A61N1/32
Filed: 2014-04-13
Abstract: AB STRACT A system and method for treating the skin by heating at least one discrete skin volume, comprising at least one treatment tip reversibly connectable to at least one applicator. The treatment tip comprises one or more electrodes, with the electrodes having one or more spaced apart protruding conducting elements. The protruding conducting elements are characterized by dimensions of height A and hypotenuse B, where the ratio A/B is in a predetermined range, and the protruding conducting elements penetrate the skin surface at discrete locations. The electrodes are configured to apply energy to skin volumes around the discrete locations so as to heat the skin volumes. The applicator comprises an energy generator configured to apply energy to the skin volumes by means of the electrodes and the spaced apart protruding conducting elements. Date Recue/Date Received 2020-09-05
Patent CA-3092568-A1 (CA)
Inventor: HUFF BRIAN R
IPC: B60L50/60
Filed: 2019-02-27
Abstract: L'invention concerne un système d'alignement et de verrouillage pour un ensemble batterie. Le système peut être situé à bord d'un véhicule électrique alimenté par un bloc-batterie disposé dans l'ensemble batterie. Le système comprend un ensemble d'éléments de réception fixés au châssis. L'ensemble batterie comprend une cage avec des barres de montage. Lorsque les barres de montage sont reçues dans les éléments de réception, elles peuvent être verrouillées en place contre le châssis. Le système peut également comprendre un ensemble de blocs en V qui viennent en prise avec des barres orientées verticalement dans la cage pour aider à l'alignement horizontal de l'ensemble batterie.
Patent CA-3092609-A1 (CA)
Inventor: GUILLOT MATTHIEU
IPC: G02C7/06
Filed: 2019-03-01
Abstract: A lens element intended to be worn in front of an eye of a wearer comprising: - a refraction area having a refractive power based on a prescription for said eye of the wearer; and - a plurality of at least two contiguous optical elements, at least one optical element having an optical function of not focusing an image on the retina of the eye of the wearer so as to slow down the progression of the abnormal refraction of the eye.
Patent CA-3093235-A1 (CA)
Inventor: IOUALALEN KARIM
IPC: A61K9/14
Filed: 2019-03-07
Abstract: The invention relates to a gastroprotected, hydrophobic formulation of at least one active principle, characterised in that it is presented in the form of solid particles having a size of 5 µm to 3500 µm, the solid particles of the formulation comprising: - at least one waxy carrier forming a waxy matrix, and; - said at least one active principle chosen from the group made up of active principles for agri-food use, active principles for veterinary use, active principles for probiotic use, and active principles for pharmaceutical use; the solid particles being strictly hydrophobic, non-hygroscopic, non-injectable, free of water, free of surfactants, free of emulsifying agents, free of solvent, and free of shear-thinning polymer; the solid particles having a melting point of between 15°C and 60°C; said at least one active principle being uniformly distributed in the waxy matrix with a weight ratio of between 0.2% and 85%; said solid particles being suitable for protecting and stabilising said at least one active principle in the gastric medium and being dispersible in the intestinal medium.
Patent CA-3094161-A1 (CA)
Title: Compositions et procedes d'utilisation d'enzymes genetiquement modifiees
Inventor: MENDEZ MICHAEL
IPC: C12N15/82
Filed: 2019-03-19
Abstract: La présente divulgation concerne la biosynthèse de cannabinoïdes et autres composés phénoliques prénylés apparentés à l'aide d'enzymes recombinées. En particulier, la présente divulgation concerne des enzymes ORF2 mutantes recombinées génétiquement modifiées pour produire une plus grande quantité de produit souhaité, ou pour avoir une capacité supérieure à catalyser une réaction à l'aide d'un substrat souhaité, comparativement à ORF2 WT. Des procédés de préparation desdites enzymes mutantes ORF2, ainsi que leurs procédés d'utilisation pour améliorer la biosynthèse des cannabinoïdes et autres composés phénoliques prénylés apparentés sont en outre décrits.
Patent CA-3094377-A1 (CA)
Title: Compositions and methods of detecting and treating alzheimer's disease
Inventor: UNGER EVAN C
IPC: A61K49/18
Filed: 2019-03-28
Abstract: The invention provides microbubbles and/or nanodroplets labeled with diagnostic and/or therapeutic ligands that are useful in the detection and treatment of Alzheimer's disease, or related diseases and conditions, as well as methods of preparation and use thereof.
Patent CA-3095625-A1 (CA)
Inventor: ZIEGER PETER
IPC: A61F9/007
Filed: 2019-05-22
Abstract: La présente invention concerne un système qui peut afficher une interface utilisateur graphique (GUI) qui comprend une icône par l'intermédiaire d'un dispositif d'affichage ; peut recevoir une première image provenant d'un capteur d'image ; peut déterminer, à partir de la première image et d'un modèle numérique d'équipement d'outillage chirurgical, une première position de l'équipement d'outillage chirurgical dans la première image ; peut afficher un curseur de la GUI dans une deuxième position ; recevoir une seconde image provenant du capteur d'image ; peut déterminer, à partir de la seconde image et du modèle numérique, une troisième position de l'équipement d'outillage chirurgical dans la deuxième image ; peut afficher le curseur de la GUI dans une quatrième position ; peut recevoir une entrée utilisateur qui indique une sélection tandis que les coordonnées de l'icône comprennent la quatrième position ; et peut déterminer que l'entrée utilisateur indique la sélection tandis que les coordonnées de la ou des icônes comprennent la quatrième position.
Patent CA-3095663-A1 (CA)
Title: Aqueous coating composition
Inventor: QIAN ZHEN
IPC: C09D5/02
Filed: 2018-04-12
Abstract: Provided is an aqueous coating composition having good freeze-thaw stability and providing coatings with good stain resistance. The aqueous coating composition comprises an emulsion polymer comprising a vinyl aromatic monomer and a polymerizable surfactant, a polyoxypropylene polyol, a phosphate surfactant, and a functional silane.
Patent CA-3097085-A1 (CA)
Inventor: DERVAL NICOLAS
IPC: A61B5/02
Filed: 2019-05-02
Abstract: Medical device (1) having: ? a catheter (10), characterized in that it comprises a first lumen (LU1) for injection of a first volume of a treatment solution (Sol1) and a second lumen (LU2) for injection of a second volume composed of a gas or a liquid (Sol2) for inflation of a balloon (20); ? a balloon (20) fixed on a portion of the distal end of the catheter (1), said balloon (20) having an opening (21) to permit entry of the second volume (Sol2), in order to ensure inflation of the balloon (20) via the second lumen (LU2), and having a predefined inflation shape defining a channel that opens out laterally with respect to the main axis of the catheter (1).
Patent CA-3098305-A1 (CA)
Inventor: STARK ROBERT
IPC: B02C19/18
Filed: 2019-04-26
Abstract: The invention relates to a fragmentation system (1) for an electrodynamic fragmentation of material (5), comprising a feed (3) and an outlet (4) for transporting material along a transport path (8) in a transport direction (9), comprising at least one high-voltage pulse source (11), wherein each of the high-voltage pulse sources (11) has at least one first electrode (10a) and at least one second electrode (10b) for generating a high-voltage discharge (19) in a discharge chamber, and the transport path (8) has a fractionation section (18), said fractionation section (18) running through the discharge chamber. The fragmentation system also comprises a selection means for a selective discharge of the material (5) on the transport path in order to extract material (5) and/or fragments of the material with a diameter which is smaller than a minimum diameter at at least one part of one of the fractionation sections (18). In a method for an electrodynamic fragmentation of material (5), material (5) is transported from an inlet (3) to an outlet (4) along a transport path (9). The transport path (8) has a fractionation section (18), at least one high-voltage pulse source (11) has at least one first electrode (10a) and at least one second electrode (10b), and the high-voltage pulse source (11) generate a high-voltage discharge in a discharge chamber, said discharge chamber being arranged between the first electrode (10a) and the second electrode (10b). Material (5) and/or fragments of the material with a diameter which is smaller than a minimum diameter is extracted at at least one part of one of the fractionation sections (18).
Patent CA-3098465-A1 (CA)
Inventor: CAO JINAN
IPC: A61P27/12
Filed: 2019-04-28
Abstract: This patent application discloses a method of manufacturing eye drops that can be used to ameliorate or cure eye conditions such as cataracts, presbyopia, glaucoma, astigmatism, dry eye as well as for generic eye care uses. The sole active ingredient of said eye drops is citric acid - its aqueous solution around 0.9% by weight, which can be adjusted to either higher or lower levels of concentration according to clinical needs. Citric acid can be sourced either from industrial products or from natural fruits such as lemons and pineapples.
Patent CA-3099524-A1 (CA)
Title: Solid carrier component including a liquid polyorganosiloxane and methods for preparation and use of the solid carrier component
Inventor: COURTEMANCHE MARC-ANDRE
IPC: C08L97/02
Filed: 2020-06-10
Abstract: A solid carrier component includes a liquid polydiorganosiloxane, an ethylene-based polymer, and a maleated ethylene-based polymer. The solid carrier component is useful in processes for preparing filled composite articles, such as wood plastic composite building materials.
Patent CA-3099654-A1 (CA)
Inventor: KARIM KARIM S
IPC: G01T1/29
Filed: 2019-05-07
Abstract: This method and system provide an imaging system for producing static and dynamic images from electromagnetic radiation such as x-rays and high-energy electrons. The detector includes a top electrode layer, a photoconducting layer and a bottom electrode layer. Within the bottom electrode layers are a set of pixel circuits for sensing the radiation. The photoconducting layer has a thickness at least three times greater than the pitch of one of the individual pixel circuits.
Patent CA-3101180-A1 (CA)
Title: Tricyclic heterocycle compounds useful as hiv integrase inhibitors
Inventor: YU TAO
IPC: A61K31/4985
Filed: 2019-04-22
Abstract: The present invention relates to Tricyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, R4, R5, R6 and n are as defined herein. The present invention also relates to compositions comprising at least one Tricyclic Heterocycle Compound, and methods of using the Tricyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.
Patent CA-3101408-A1 (CA)
Inventor: PRINZ MARTIN
IPC: A61L27/60
Filed: 2019-06-14
Abstract: L'invention concerne une composition d'hydrogel stérile comprenant un polymère réticulé, le polymère réticulé étant un produit d'oxydation d'un hyaluronane modifié par un thiol et l'hyaluronane modifié par thiol ayant un degré de modification de l'hyaluronane avec des fractions thiol de plus d'environ 80 µmoles par gramme de polymère, l'hyaluronane modifié par thiol ayant un degré de modification de hyaluronane avec des fractions thiol inférieure à environ 280 µmol par gramme de polymère, et l'hyaluronane modifié par thiol ayant un poids moléculaire moyen d'au moins 400 kDa.
Patent CA-3102966-A1 (CA)
Inventor: BARAK AYALA
IPC: C02F1/50
Filed: 2019-06-03
Abstract: A system and method for monitoring process water treated with a biocide is provided. The system includes a biocide feeding unit and a dissolved oxygen sensor. The dissolved oxygen sensor works in two modes, a biocide feeding mode and a background mode, and alerts an operator when the dissolved oxygen value indicates a fault in the system. A drop in dissolved oxygen during feeding can indicate faulty production of biocide or biocide degradation, both of which can lead to unwanted disinfection by-products.
Patent CA-3104536-A1 (CA)
Title: Antibodies binding to vista at acidic ph
Inventor: JOHNSTON ROBERT J
IPC: C07K16/28
Filed: 2019-07-10
Abstract: The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.
Patent CA-3106283-A1 (CA)
Title: System and method for out-of-sample representation learning
Inventor: ALBOOYEH MARJAN
IPC: G06F7/58
Filed: 2021-01-15
Abstract: ABSTRACT Disclosed are systems, methods, and devices for out-of-sample representation learning using knowledge graphs. An embedding data structure reflective of a knowledge graph embedding model is received. A training data set including a plurality of training data entries, each of the training data entries reflective of a head entity, a tail entity, and a relation therebetween, wherein at least one of the head entities or the tail entities includes an out-of-sample entity, is received. A plurality of knowledge graph embedding model processors is provided. A random number is generated and compared to to at least one criterion. A knowledge graph embedding model processor is selected from among the plurality of knowledge graph embedding model processors based at least in part on the comparing. The embedding data structure is processed with the selected knowledge graph embedding model processor. CAN_DMS: \137253297\6 Date Recue/Date Received 2021-01-15
Patent CA-3108135-A1 (CA)
Title: Vesicules extracellulaires specifiques a une cible
Inventor: WOZNIAK-KNOPP GORDANA
IPC: C07K14/195
Filed: 2019-08-14
Abstract: L'invention concerne un procédé de production d'une protéine comprenant un domaine extravésiculaire spécifique à une cible (TED) d'une protéine de surface de vésicule extracellulaire (EV) comprenant la modification d'un polynucléotide comprenant une séquence nucléotidique codant pour le domaine extravésiculaire (ED) d'une protéine de surface d'EV par un procédé de mutagenèse dans au moins une région modifiée dans la séquence d'acides aminés d'ED avec une longueur de 3 à 20 acides aminés contigus flanqués par des régions de la séquence d'ED de type sauvage à ses extrémités N-terminale et C-terminale, pour incorporer un site de liaison à une cible à l'intérieur de l'ED, ce qui permet de produire un répertoire de polynucléotides codant pour divers TED, comprenant chacun un site de liaison à une cible différent, et la sélection d'un TED reconnaissant spécifiquement une cible prédéfinie, et la production de la protéine comprenant le TED sélectionné.
Patent CA-3109997-A1 (CA)
Title: Method for determining the curvature of a glass pane, more particularly a windshield
Inventor: LAUVEN GUNTER
IPC: G01B11/25
Filed: 2019-07-30
Abstract: The subject matter of the invention is a method for determining the curvature of at least one glass pane (7, 8, 9), using at least three triangulation sensors (3, 17, 18), which in a transverse direction (2) have different positions, comprising an inner triangulation sensor (17) and at least two outer triangulation sensors arranged in the transverse direction (2) outside the inner triangulation sensor (17), wherein the outer triangulation sensors (18) record position data of at least two positions in the transverse direction (2). This can be done for example by moving the outer triangulation sensors (18) in the transverse direction (2) or by increasing the number of outer triangulation sensors (18), or also by arranging triangulation sensors (17, 18) that simultaneously record data of several positions in the transverse direction (2).
Patent CA-3110307-A1 (CA)
Title: Device for producing foamed construction materials
Inventor: GAWRYCK HOLGER
IPC: B28C5/12
Filed: 2019-08-22
Abstract: The invention relates to a device (110) for producing foamed construction materials, comprising a gas supply unit (112), a suspension supply unit (150-156) and a mixing chamber (118). The device (110) also comprises an open-loop and/or closed-loop control unit (136), which has means (116, 124, 130, 134, 146) for supplying values of a plurality of input parameters, on the basis of which at least the temperature of the dispersion and the air pressure in the surroundings of the device (110) can be inferred. The open-loop and/or closed-loop control unit (136) is also designed to influence at least one output parameter, by means of which the ratio of the volumes and/or masses and/or densities of gas and suspension fed per unit time can be set. The invention further relates to a corresponding method.
Patent CA-3110961-A1 (CA)
Inventor: TERRY ANDREW J
IPC: F16K27/00
Filed: 2021-03-02
Abstract: Il est décrit une unité de robinet d'isolement avec une sortie de fusion qui comprend un corps de robinet composé d'un métal, tel que le laiton, et ayant au moins deux ports, au moins un des ports comprenant une extrémité thermoplastique surmoulée entourant et renfermant le port à partir duquel la sortie de fusion s'étend. Selon une réalisation, l'extrémité thermoplastique est composée d'un matériau PP-RCT et est solidement formée sur l'orifice au moyen d'une technique de surmoulage. L'unité de robinet comprend également un robinet à tournant sphérique logé dans le corps du robinet et une poignée pour actionner le robinet à tournant sphérique. L'unité de robinet d'isolement est conçue de manière à se coupler à un tuyau polymère plus large et à contrôler le flux de fluides dans une installation de plomberie par l'actionnement du robinet à tournant sphérique.
Patent CA-3114373-A1 (CA)
Title: Natural product composition for stimulating hair growth
Inventor: PETCAVICH ROBERT J
IPC: A61K8/02
Filed: 2019-09-30
Abstract: The present invention discloses a novel combination of a natural product and minoxidil for the treatment of hair loss and regrowth. In the preferred embodiment, Sandalore® and its analogs are combined with minoxidil and formulated into a solution for the treatment and regrowth of mammalian hair loss. In another embodiment, Sandalore® and its analogs are combined with rosemary oil, emu oil or a combination thereof.
Patent CA-3114776-A1 (CA)
Inventor: MOK DANIEL WING FAI
IPC: A61B18/14
Filed: 2021-04-13
Abstract: A puncturing device configured to create a puncture in a tissue having a maneuverable distal portion which is connected to a distal tip. A handle with an actuation mechanism is at the proximal portion of the puncturing device. The maneuverable distal portion is coupled to the actuation mechanism, where upon actuation of the actuation mechanism manipulates the maneuverable distal portion, thereby manipulating the distal tip of the puncturing device.
Patent CA-3116262-A1 (CA)
Inventor: BRANDT BARON C
IPC: A41C3/12
Filed: 2018-02-23
Abstract: Aspects herein provide for a support garment having a vibration damping structure that is positioned between the breast contacting surfaces of the support garment. The vibration damping structure has a shape and/or material characteristics that enable it to substantially fill the space defined by a medial aspect of the wearer's breasts and the wearer's sternum. This positioning and placement facilitate the damping structure's ability to absorb and dissipate impact forces generated at least through the medial-to-lateral movement of the wearer' s breasts during, for example, athletic activities.
Patent CA-3117321-A1 (CA)
Title: Prediction engine for a network-based service
Inventor: MENG SHICONG
IPC: G06N3/02
Filed: 2019-10-18
Abstract: Service providers can be identified to fulfill service requests of a network-based service. A network system is configured to generate, based on historical data associated with the network-based service, a machine-learned service provider optimization (MLSPO) model for generating service provider optimizations. The optimizations can include action recommendations that optimize one or more service metrics. The MLSPO model can be a reinforcement learning model generated by performing a plurality of simulations utilizing one or more virtual agents. A provider device of a service provider can transmit a set of data to the network system that indicates a current location of the service provider. Based on the current location and the MLSPO model, the network system can generate service provider optimizations. Optimization data can be transmitted to the provider device so that the provider device can display information corresponding to the service provider optimizations.
Patent CA-3121409-A1 (CA)
Title: Encoder, decoder and corresponding methods of most probable mode list construction for blocks with multi-hypothesis prediction
Inventor: WANG BIAO
IPC: H04N19/70
Filed: 2019-11-29
Abstract: A method of decoding a block of a picture, comprising: obtaining an indication parameter for a current coding block (801). The indication parameter represents whether a multi-hypothesis prediction is applied to the current coding block. When the indication parameter represents that the multi-hypothesis prediction is applied to the current coding block (802), decoding the current coding block according to a planar mode (803).
Patent CA-3121607-A1 (CA)
Title: Method for enhancing the growth and survival rate of microorganisms
Inventor: BOA TYLER
IPC: A01N25/22
Filed: 2019-12-11
Abstract: The present disclosure concerns a method for enhancing or promoting or increasing the fermentative potential of microbial populations and/or the growth rate of microorganisms. The present disclosure also proposes a method for improving survival, viability and/or stability of microorganisms in microbial products, suspensions or of microbial inoculants, during storage.
Patent CA-3121684-A1 (CA)
Inventor: PIETRZAK CHRISTOPHER
IPC: A42B3/06
Filed: 2019-12-03
Abstract: The present invention provides a helmet, comprising first and second components having a sliding interface between them, wherein the sliding interface is provided between respective sliding surfaces of the first and second components, and the first component comprises (a) a mixture of (i) an olefin polymer, (ii) a lubricant, and optionally one or more further agents; or (b) an ultra high molecular weight (UHMW) polymer having a density of = 960 kg/m3, which UHMW polymer is preferably an olefin polymer.