baber/WOPTO huggingface dataset:
Patent FI-90144-B (FI)
Inventor: FOERDER WALTER
IPC: G01R21/00
Filed: 1987-01-02
Granted: 1993-09-15
Abstract: 1. Electronic electricity meter having a multiplier (1, 2), operating according to the timedivision method, for first and second input quantities (U, I), the first input quantity (U) being supplied to a modulator (1), representing a component part of the multiplier (1, 2), and having a quantizer (3), subsequently connected to the multiplier (1, 2), the quantizer (3) operating according to the charge compensation method and being constructed with an integrator (17, 18) and a subsequently connected first comparator (26), characterized in that the multiplier (1, 2) and the quantizer (3) have the following features : a) during each first time phase of a clock generator (8) a first capacitor (23) is connected to the input of the integrator (17, 18), b) during each second time phase of the clock generator (8) the first capacitor (23) is charged with a charge proportional to the second input quantity (I), c) the polarity with which the first capacitor (23) is placed at the input of the integrator (17, 18) is determined by the output signal of the modulator (1), constructed according to the delta-sigma method and controlled by the clock generator (8), d) a second capacitor (25) is charged with a reference charge, while the output of the quantizer (3) is at "0", and is placed at the input of the integrator (17, 18), as long as the output of the quantizer (3) is at "1", e) a flip-flop (27), controlled by the clock generator (8), is subsequently connected to the first comparator (26), the output of the flip-flop (27) representing the output of the quantizer (3).
Patent FI-90015-B (FI)
Title: Bulking agent and its use in pharmaceutical preparation for inhalation
Inventor: CHIESI PAOLO
IPC: A61K9/72
Filed: 1987-10-26
Granted: 1993-09-15
Abstract: A new excipient which may be used in the preparation of pharmaceutical compositions in the form of powders for inhalation, constituted by microgranules of a conglomerate of one or more solid water-soluble diluents and a lubricant.
Patent FI-84266-B (FI)
Inventor: CARLIER PATRICK
IPC: C07D211/56
Filed: 1987-12-22
Granted: 1991-07-31
Abstract: Composés de formule : <CHEM> dans laquelle R et R' représentent chacun un radical alkyle ou cycloalkyle ayant 1 à 7 atomes de carbone ; X représente - O - ou H2 ; Y et Z représentent l'hydrogène ou un ou plusieurs radicaux choisis parmi les radicaux halogéno, hydroxy, alkyl linéaire ou ramifié ayant 1 à 6 atomes de carbone, alkoxy ayant 1 à 6 atomes de carbone triflurométhyle ou méthylènedioxy, n pouvant prendre les valeurs 2 ou 3, et leurs sels pharmaceutiquement acceptables. Application comme médicament cardiovasculaire.
Patent FI-83680-B (FI)
Inventor: ILVESPAEAE HEIKKI
IPC: D21F5/04
Filed: 1988-03-09
Granted: 1991-04-30
Abstract: The invention concerns a method to adhere a web (W) to a drying wire (H) against the centrifugal forces and various blow phenomena, which attempt to detach the web (W) from said wire (H) in the drying groups provided with single-wire draw in a multi-cylinder dryer of paper machine. The drying groups comprise as upper cylinders drying cylinders (K) heated by means of steam or equivalent and the web (W) is pressed by the drying wire (H) against outer cylinder faces of said drying cylinders (K). The drying groups further comprise as lower cylinders leading cylinders (10) on which the web (W) runs outside the drying wire (H), said leading cylinders (10) being provided with holes (15) passing through a mantle (11) of the leading cylinders (10). The holes (15) open into an interior space (14) of negative pressure (P1) in the leading cylinders (10) and into the outer face of said cylinders (10), said negative pressure (P1) being transmitted to said outer face through said holes (15). The leading cylinders (10) comprise shafts (18) on which the respective leading cylinder (10) is journalled revolving, and at least one of said shafts (18) has a duct (18a) through which said negative pressure (P1) is applied to the space (14) inside said cylinder (10). The shafts (18) communicate with a suction duct (19) from a source (20) of said negative pressure (P1). A part of the holes (15) in each leading cylinder (10) opens into the open air in the upper part of the leading cylinder (10) so that flow of air is directed into the interior (14) space of said cylinder. Said negative pressure (P1) in said interior space (14) is selected within the range of 1000 Pa to 3000 Pa. <IMAGE>
Patent FI-96578-B (FI)
Inventor: JAEGER HALVOR
IPC: A61L15/16
Filed: 1989-04-28
Granted: 1996-04-15
Abstract: PCT No. PCT/DE88/00478 Sec. 371 Date Jun. 9, 1989 Sec. 102(e) Date Jun. 9, 1989 PCT Filed Aug. 3, 1988 PCT Pub. No. WO89/01788 PCT Pub. Date Mar. 9, 1989.The invention relates to an apparatus for the controlled delivery or release of nitroglycerin to the human or animal skin, preferably in plaster form with a nitroglycerin-impermeable backing layer, a one or multiple-part reservoir containing a pressure sensitive adhesive nitroglycerin in uniform or irregular distribution and optionally a removable protective layer impermeable for nitroglycerin, the reservoir being produced using hol melt pressure sensitive adhesives with a processing temperature of 40 DEG  to 80 DEG  C., preferably 40 DEG to 60 DEG  C. and in particularly preferred manner 40 DEG  to 45 DEG C., a process for the production thereof and the use of the apparatus for therapeutic purposes in human and veterinary medicine.
Patent FI-98879-B (FI)
Inventor: WITT DANIEL P
IPC: B65D81/28
Filed: 1989-06-19
Granted: 1997-05-30
Abstract: A method is provided for controlling the biological characteristics of a solid, liquid or gaseous material (22) by contacting the material with one or more substantially insoluble substances of a composition to be active upon the material (22). The substance(s) may be for example an agglutinating polymer such as a lectin, antibody, or polysaccharide, having a high affinity for biological cells in the material and/or an amine-containing compound capable of inhibiting cell growth in a complex medium (22) and/or a binding composition having affinity for at least one biological growth factor of the cells.
Patent FI-93336-B (FI)
Inventor: KARILAINEN JARMO
IPC: B65G11/14
Filed: 1992-08-20
Granted: 1994-12-15
Abstract: A discharge chute especially for use in connection with a concrete carrying mixer, such as a rotating container or a like mounted on the chassis of a truck. The discharge chute (1) includes at least two substantially overlapping chute sections (1a, 1b, 1c) movable relative to each other in the longitudinal direction (s) of discharge chute (1) preferably by means of hydraulic drive mechanisms or the like. Each chute section (1a, 1b, 1c) includes an intermediate portion (a), comprising a discharge through, and edge portions (b) which are fitted with a slide-support assembly for enabling the relative movement of overlapping chute sections and for bracing the same together. The edge portions (b', b") of chute sections (1a, 1b, 1c) of discharge chute (1) are essentially identically shaped in cross section and thus adapted to be overlapped on each other and, thus, being spaced a distance from each other, essentially form said slide-support assembly.
Patent FI-102974-B (FI)
Inventor: KIERKELS JOANNES GERARDUS THEO
IPC: C12P41/00
Filed: 1993-12-17
Granted: 1999-03-31
Abstract: The invention relates to the preparation of an optically active ester of trans-3-phenylglycidic acid in which a mixture of the 2 enantiomers of the trans-3-phenylglycidic acid ester is stereoselectively hydrolyzed using an enzyme originating from Candida antarctica and the non-hydrolyzed ester is separated off from the reaction mixture. A racemic mixture of trans-phenylglycidic acid esters is selectively and enzymatically hydrolyzed in a relatively short reaction time, the residual ester being obtained in a high yield and with a high e.e. Such esters are used for the preparation of pharmaceuticals such as benzothiazepines and benzazepines.
Patent FI-117120-B (FI)
Inventor: TROFAST EVA ANN-CHRISTIN
IPC: C07D213/28
Filed: 1996-02-26
Granted: 2006-06-30
Abstract: PCT No. PCT/SE94/00780 Sec. 371 Date Jan. 30, 1995 Sec. 102(e) Date Jan. 30, 1995 PCT Filed Aug. 25, 1994 PCT Pub. No. WO95/05805 PCT Pub. Date Mar. 2, 1995The present invention relates to a process for providing a stable crystallinic form to a fine-grained substance or a substance mixture, which can be produced, stored and used while maintaining the aerodynamic properties required for inhalation of such a substance or a substance mixture, by a) in case of a substance mixture, preparing a homogenous mixture of the substances; b) micronizing, direct precipitating or diminishing by any conventional method the substance or substance mixture into a particle size required for inhalation, the particle size being less than 10  mu m; c) optionally preparing a homogenous mixture of the desired substances when each substance has been introduced from stage b) as separate fine-grained particles; d) conditioning said substance or substance mixture by treatment with a water containing vapor phase in a controlled fashion; and e) drying.
Patent FI-108273-B (FI)
Inventor: KRESSE FRANZ
IPC: D04D9/00
Filed: 1997-04-23
Granted: 2001-12-31
Abstract: PCT No. PCT/EP95/04093 Sec. 371 Date Apr. 25, 1997 Sec. 102(e) Date Apr. 25, 1997 PCT Filed Oct. 18, 1995 PCT Pub. No. WO96/13192 PCT Pub. Date May 9, 1996A flat mop head for cleaning floors includes a cover panel with structure fastening on its top surface and a highly absorbent material at least partially made of cotton and/or viscose in the central area of its bottom surface. At least the longitudinal sides of the cover panel are provided with a hem. A textile rim both at least partially surrounds the edges of the cover panel, and forms the hem. The cover panel consists of at least partially mixed yarns made of synthetic and natural fibers. This wash-resistant cover panel is inexpensive to produce, may be used both for wet and dry cleaning tasks, slides easily on the floor, and has high cleaning power both for water-soluble and solid soil.
Patent HU-186735-B (HU)
Inventor: KOEVECSES JOZSEF
IPC: C01G45/00
Filed: 1980-05-26
Abstract: A találmány agyagásvány tartalmú zagyok, előnyösen mangánércek savas feltárásakor keletkező zagyok szétválasztására vonatkozik. Az eljárás során melléktermékként olyan finom iszapot nyerünk, amelyet szuszpendáló szerként hasznosíthatunk, előnyösen a műtrágyagyártásban. A találmány szerinti eljárást az jellemzi, hogy a 40-80 °C-ra felmelegített 100—600 g/1, előnyösen 200-400 g/1 szilárdanyag tartalmú zagy pH-ját lúg adagolással 4-7 közé állítjuk be, ezután a zagyhoz polimer flokkuláló szer vizes oldatát, előnyösen poliakrilsav-só vizes oldatát keverik 1,5:1-2,5:1 közötti mennyiségi arányban, majd a koagulált iszapot elválasztják és az 1—10 g/1, előnyösen 1-2 g/1 szilárdanyag tartalmú diszperziót 0,6-0,7 bar vákuumot alkalmazva, 60-80 °C-on olyan dobszűrőn szűrik le, melynek felületére előzőleg 40-60 mm vastagságú, előnyösen mangán-szulfáttal, feliszapolt perlit vagy kovaföld réteget vittek fel, a szűrletet elvezetik, a szűrőrétegen kialakult iszapot folyamatosan vagy szakaszosan eltávolítják és 16-24 óránként új szűrőréteget alakítanak ki.  -1-
Patent HU-190838-B (HU)
Inventor: HOKAMA TAKEO
IPC: C07C5/00
Filed: 1983-05-06
Abstract: Die Erfindung betrifft neue Herbizidzusammensetzungen, die als Wirkstoff eine Verbindung der allgemeinen Formel I, in der X ein Halogenatom oder eine Trifluormethylgruppe darstellt, Y ein Wasserstoff- oder Halogenatom oder eine Nitro- oder Cyanogruppe bedeutet, R hoch 1 einen Alkylrest darstellt, R hoch 2 ein Wasserstoffatom oder einen Alkyl-, Alkenyl- oder Alkinylrest bedeutet und R hoch 3 ein Halogenatom oder einen Alkylrest bedeutet und R hoch 3 ein Halogenatom oder einen Alkylrest darstellt, m eine ganze Zahl von 0 bis 3 ist und n eine ganze Zahl 0 oder 1 ist, enthalten.
Patent HU-191756-B (HU)
Title: Process for preparing new fluoro-alkoxy-benzimidazole derivatives
Inventor: RAINER GEORG
IPC: C07D491/056
Filed: 1984-04-27
Abstract: Benzimidazole derivs. of formula (I) and their salts are new. R is a bond and R1 is a totally or partially fluorinated 1-2C alkylene gp. or a chlorotrifluoroethylene gp., or R = R1 = CF2; R2 = H or 1-3C alkyl; R3 = H, 1-3C alkyl or 1-3C alkoxy; R4 = H or 1-3C alkyl; n = 0 or 1.
Patent HU-183977-B (HU)
Inventor: HAUPT DIETMAR
IPC: C03C8/24
Filed: 1982-06-24
Abstract: Die Erfindung betrifft ein keramisches Bindemittel zur Herstellung poroeser Korundschleifkoerper mit verbesserten mechanischen Eigenschaften, insbesondere zur Herstellung von normalporoesen (gemaess TGL 29-806) Schleifwerkzeugen fuer das Hochgeschwindigkeitsschleifen. Das Erfindungsziel ist das Auffinden eines entsprechenden keramischen Bindemittels. Die Erfindungsaufgabe besteht darin, insbesondere normalporoese Korundschleifkoerper mit Bruchumfangsgeschwindigkeiten von etwa 150 m/s und einem gewoehnlichen keramischen Gefuege mittels eines neuartigen keramischen Bindemittels herzustellen; letzteres soll darueberhinaus fuer alle poroesen Korundschleifkoerper einsetzbar sein.Erfindungsgemaess wurde eine keramische Bindemittelkomposition fuer verschiedenste Arten von Korundschleifkoernern gefunden, die aus 60 bis 98 Masse-% Alkaliborosilikatglas definierter chemischer Zusammensetzung, 1 bis 10 Masse-% Alkalihexafluoroaluminaten resp. Mischungen von Alkalifluoriden und Aluminiumfluorid und ggf. 0 bis 30 Masse-% handelsueblicher plastischer keramischer Rohstoffe besteht. Der ueberraschende synergistische Effekt des erfindungsgemaessen Bindemittels beruht schluessig in der Wirkung der Fluorid-Ionen, die die Viskositaet der eingesetzten Glaeser in der Grenzschicht zum Korund erniedrigen ohne gleichzeitig dessen Aufloeserate zu erhoehen. Dadurch wird eine sehr gute Einbindung der Schleifkoerner waehrend des Brandes ermoeglicht. Die Glasphase im gebrannten Schleifkoerper ist praktisch homogen aufgebaut und an Al tief 2 O tief 3 nahezu gesaettigt.
Patent HU-200407-B (HU)
Inventor: HANGEL PETER
IPC: A01D43/00
Filed: 1987-05-15
Abstract: A találmány berendezés kukoricanövény egymenetben való betakarítására, amely mozgásképes vázat, és a vázhoz csatlakozó, terményfőlhordóval rendelkező takarmányvágó adaptert, továbbá ugyancsak a vázra szerelt szecskázó dobos szárfeldolgozó egységet, valamint főtermék-feldolgozó egységet tartalmaz. Jellegzetessége, hogy a takarmányvágó adapter (1), valamint a szárfeldolgozó egység (2) közé főtermék-leválasztó egység (4) van beiktatva. A főtermék-leválasztó egység (4) a szárfeldolgozó egység (2) szecskázó dobja (22) elé felszerelt csőtörő szerkezettel (42), továbbá a csótóró szerkezet (42), valamint a takarmányvágó adapter (1) terményfölhordója (14) közötti gyűjtóvólyúval (41) és a gyűjtővályú (41) alá beépített szállítószervvel (43) van ellátva. A találmányhoz tartozik az eljárás is a kukoricanővény egymenetben való betakarítására, amelynek során a teljes növényt levágjuk, majd tővéggel szárazfeldolgozó egységhez továbbítjuk és a szárat szecskázzuk. Jellegzetessége, hogy szecskázás előtt a kukoricacsövet a szártól elválasztjuk és saját súlynál fogva leejtjük majd összegyűjtjük, végül pedig feldolgozzuk.  HU 200407 B A leírás terjedelme: -I oldal, 2 rajz, 3 ábra -1-
Patent HU-203603-B (HU)
Title: Method for improving physical-chemical features of the photographic layers
Inventor: SZUECS MIKLOS
IPC: G03C1/04
Filed: 1989-05-24
Abstract: A process of adding to gelatine silver halide photographic layers   a) 0.020 to 0.25 mole of a hardening or a coupling agent containing 2 glycidyl groups or epichlorohydrin and b) 10 to 100g of a cyclodextrin or a cyclodextrin polymer and/or a polyethylene imine  or   (ii) 0.020 to 0.25 mole of formaldehyde or glyoxal and 10 to 100 g of a polyethylenimine polymer of the general formula (VII) or (iii) 0.020 to 0.25 mole of epichlorohydrin or a coupling agent, containing 2 glycidyl groups and 10 to 100 g of gelatin-cyclodextrin copolymer and optionally a polyethylenimine calculated for 100 g of gelatin of the photographic emulsion or gelatin solution, where the gelatin/cyclodextrin ratio in the copolymer added may be varied from 10:90 to 90:10. The addition gives good development diffusion, minimum hydration and sufficient hardness.
Patent HU-201846-B (HU)
Inventor: VIG LASZLO
IPC: G02C7/02
Filed: 1988-06-15
Abstract: A találmány tárgya optikai eszköz, különösen gyógyászati segédeszköz, elsősorban a szem hibáinak korrigálására, amelynek keretbe foglalt meghatározott dioptriájú lencséje(i) és a kerethez csatlakozó felfogóeleme van. A taláhnány szerinti optikai eszköznek két légmentesen összekapcsolt fóliából (3) és a fóliák (3) által határolt, a fóliák (3) törésmutatójával közel azonos törésmutatójú folyadékkal kitöltött folyadéktérből (9) kialakított, a keretbe (1) rugalmasan ágyazott lencséje(i) és a folyadéktérhez (9) csatlakozó és a folyadékteret (9) kitöltő folyadék nyomását, ezzel a fóliák (3) domborúságát változtató szabályozóeleme (7) van, ahol a folyadéktér (9) és a szabályozóelem (7) egy közös zárt teret képez (1. ábra). A leírás terjedelme: 3 oldal, 1 ábra  HU 201 846 B -1-
Patent HU-186127-B (HU)
Inventor: HORVATH BENEDEK
IPC: B60B21/00
Filed: 1982-09-27
Abstract: A találmány öntisztító gumikerék, főként mezőgazdasági gépek, erőgépek járókerekeihez, vezetőkerekeihez, mélységhatároló kerekeihez. A kerék kerékpárral egybeépített kerékpántból, és a speciálisan kialakított, tömlő nélküli gumiabroncsból áll. A gumiabroncs belső felületének és belső terének a kialakítása biztosítja az öntisztító hatást.  -1-
Patent HU-217573-B (HU)
Title: Process for destroying plant pests
Inventor: DR FOWLER ELIZABETH
IPC: A01H5/00
Filed: 1989-06-20
Abstract: The present invention relates to a process for controlling plant pests, which is based on proteinase inhibitors which are synthesized in the plant as a result of genetic manipulation. It also relates to transgenic mono- and dicotyledonous plants which contain genes which encode proteinase inhibitors or their precursors, and plants which express these genes and a process for controlling plant pests by exposing these to such a transgenic plant. The invention further relates to DNA sequences and vectors which contain these sequences and which encode proteinase inhibitors.
Patent HU-218484-B (HU)
Title: New process for producing 10beta-h-steroids
Inventor: DR CLEVE ARWED
IPC: C07J31/00
Filed: 1991-06-03
Abstract: PCT No. PCT/EP91/01018 Sec. 371 Date Nov. 30, 1992 Sec. 102(e) Date Nov. 30, 1992 PCT Filed Jun. 3, 1991 PCT Pub. No. WO91/18918 PCT Pub. Date Dec. 12, 1991.A process for the production of 10 beta -H-11 beta -(substituted phenyl) steroids of the formulae Ia or Ib set forth in the claims by reduction of a compound of the formula III:    <IMAGE>  (III)  followed by cleaving with a strong acid or partial cleaving with a less strong acid. Reduction with an electropositive metal in an electron-solvating solvent is preferred.
Patent HU-208331-B (HU)
Title: Process for producing organic mineral products
Inventor: HILTERHAUS KARL-HEINZ
IPC: C08G18/38
Filed: 1989-07-26
Abstract: Organo-mineral prods. are prepd. by reaction of (a) an organic polyisocyanate in presence of (b) and aq. alkali silicate soln., and of (c) an epoxide resin which reacts with the polyisocyanate or with intermediates formed from this, with formation of organic polymer structures contg. oxazolidinone rings.
Patent HU-195814-B (HU)
Title: Process for the production of derivatives of tetrahydrobeta-carbolins and medical preparatives containing thereof
Inventor: BIERE HELMUT
IPC: A61P25/28
Filed: 1986-10-03
Abstract: 5,6,7,8-tetrahydro-beta-carbolines derivatives of formula I <IMAGE>  (I)  wherein R1 is an oxadiazolyl radical of the formula <IMAGE>   COOR3 or CONR4R5, R2 is H, lower alkyl or cycloalkyl, R3 is H or lower alkyl, R4 and R5 are H or lower alkyl, whereby R4 and R5 cannot be hydrogen at the same time, or R4 and R5 together with the adjacent nitrogen atom form a 5- or 6-member ring, which additionally can contain a heteroatom, and RA is hydrogen, =O, cycloalkyl, -COOR3 with R3 having the above-mentioned meanings, or lower alkyl, which optionally can be substituted by OH, halogen, lower alkoxy, phenyl, phenyloxy, -NR4R5, whereby R4 and R5 have the above-mentioned meanings, and RB can be hydrogen, lower alkyl or lower alkoxyalkyl, have valuable pharmacological properties.
Patent HU-191619-B (HU)
Inventor: ALMASI LASZLO
IPC: G06F12/00
Filed: 1983-12-14
Abstract: A találmánynak az a lényege, hogy az (1) mikroprocesszor (9) belső címsínen keresztül (5) multiplexerre, (13) átkapcsolható cítniueghajtóra, illetve (2) összeadóra csatlakozik, továbbá az összeadó (6) indextárra, illetve a (13) átkapcsolható címmeghajtóra kapcsolódik, valamint az (5) multiplexer (17) indextár clmsínen keresztül a (6) indextárra van kötve.  -1-
Patent HU-196666-B (HU)
Inventor: IFJ SARINGER KALMAN
IPC: G05D16/20
Filed: 1984-12-06
Abstract: A találmány tárgya áramköri elrendezés elpárologtatóból, azzal sorbakötött kompresszorból, léghűtéses kondenzátorból álló, freon hűtőközeggel feltöltött zárt hűtőrendszer hűtési teljesítményének optimális munkapontra történő beállítására. Áz áramköri elrendezésnek szabályozó erősítője (2) van, amelynek rcfcrcneiabcmcnctcrc (22) beállított rcfcrcnciafcszültseg (Ur<,f) csatlakozik, kimenete (23) vezérlő áramkör (3) bemenetére (31), a vezérlő áramkör (3) kimenete (32) gyújtásszög vezérlésére alkalmas teljesítménykapcsoló elem (4) bemenetére (41), a teljesítménykapcsoló elem (4) egyik kimeneté (42) ventilátor motor (5) egyik bemenetére (51), másik kimenete (43) váltakozó áramú tápfeszültség (6) egyik kapcsára (61), a ventilátor motor (5) másik bemenete (52) a váltakozó áramú tápfeszültség (6) másik kapcsára van (62) kötve. Az áramköri elrendezésre jellemző, hogy a léghűtéses kondenzátor (KON) kimenetére érzékelő szervként piezorezisztiv mérőcella (I) nyomásbemenete (11), a piezorezisztiv mérőcella (I) fcszültscgkimcnctcre (12) a szabályozó erősítő (2) érzckclőbemcnetc (21) csatlakozik. A ventilátor motor (5) kimenete (53) a léghűtéses kondenzátor (KON) hütőventilátorának tengelyével (T) van kapcsolatban (I. ábra).  -1-
Patent HU-195667-B (HU)
Title: Process for production of derivatives of nitroantracyclin
Inventor: ANGELUCCI FRANCESCO
IPC: A61K31/704
Filed: 1986-11-18
Abstract: Anthracycline glycosides of the general formula (A'):   <IMAGE> wherein R1 represents a hydrogen atom, a hydroxy group or a methoxy group; one of R2 and R3 represents a hydroxy group and the other of R2 and R3 represents a nitro group; and R4 represents a hydrogen atom or a hydroxy group; and their pharmaceutically acceptable salts; have anti-tumor activity.
Patent HU-198948-B (HU)
Title: Process for producing diphosphonic acid derivatives and pharmaceutical compositions comprising same as active ingredient
Inventor: BOSIES ELMAR
IPC: C07F9/547
Filed: 1987-11-27
Abstract: Diphosphonic acids of the formula I 
<IMAGE>
 in which
 Het denotes a hydrogenated or partially hydrogenated heterocyclic ring having one or two nitrogen atoms which, independently of one another, can optionally be substituted by lower alkyl, benzyl or cyclohexylmethyl,
 B denotes a nitrogen atom or a C-H group, where the C-atom substituted by G can also form a double bond with B,
 R1 and R2 each denote hydrogen, lower alkyl or together denote an alkylene chain having 3 - 5 carbon atoms, where these can thus contain a Het-fused ring with up to 3 double bonds, 
<IMAGE>
 in which R3 denotes hydrogen or lower alkyl,
 alk denotes a valency line or a straight-chain or branched alkylene chain having 1 - 6 carbon atoms which must not start from a hetero atom,
 X denotes hydrogen, hydroxyl or an amino group,
 G denotes hydrogen or the radical Ys and
 m, r and s can each be 0 or 1, where m + r + s must always be 1,
 with the proviso that if alk denotes a valency line, Het must not represent a pyrrolidine ring substituted in the 2-position by Y,
 and their pharmacologically acceptable salts are used for the treatment of disorders of calcium metabolism.