baber/WOPTO huggingface dataset:
Patent PT-1185551-E (PT)
Title: Method for purification of proteins
Inventor: WINGE STEFAN
IPC: A61K47/12
Filed: 2000-06-08
Abstract: The present invention relates to methods for purification of antithrombin-III (AT-III) by precipitation of impurities. The said methods comprise (a) adding, to a solution comprising antithrombin-III, a saccharide and citrate, in an amount sufficient for impurities to precipitate while antithrombin-III essentially remains in solution; (b) allowing impurities to precipitate; and (c) removing the precipitated impurities, thereby obtaining a solution comprising purified antithrombin-III. The invention also relates to pharmaceutical compositions, obtainable by the said methods, comprising purified antithrombin-III, as well as to reconstituted pharmaceutical compositions essentially free from visible particles.
Patent PT-1292607-E (PT)
Title: Novel solid body forms of mesoprogestin 11beta- 4e-(hydroxyiminomethyl)-phenyl -17alpha-methoxymethyl-17beta-methoxy-estra-4,9-dien-3-one
Inventor: GRAWE DETLEF
IPC: A61P15/08
Filed: 2001-05-09
Abstract: Nonsolvated crystalline 11beta -(4-((E)-hydroxyiminomethyl)phenyl)-17alpha -methoxymethyl-17beta -methoxy-4,9-estradien-3-one (I) is new. An independent claim is also included for a process for preparing (I). ACTIVITY : Gynecological. MECHANISM OF ACTION : Progesterone receptor ligand.
Patent PT-1264000-E (PT)
Title: Method for depositing amorphous silicon layers that contain hydrogen
Inventor: KLAGES CLAUS-PETER
IPC: C23C14/00
Filed: 2001-03-08
Abstract: The invention relates to a method for coating a substrate (1) with amorphous silicon layers (7) that contain hydrogen (a-Si:H layers). A sputtering gas and a reactive gas (4), which contains Si or an Si compound, is injected into a gas flow sputtering source (8) with a target (2) that contains silicon.
Patent PT-1368491-E (PT)
Title: Method of selection, by two-dimensional separation, of nucleic acids that bind to a target with high affinity
Inventor: ANDREAS KAGE DR
IPC: C12Q1/6811
Filed: 2001-10-02
Abstract: The invention relates to a method of selection, by two-dimensional separation, of nucleic acids that bind to a target molecule with high affinity from a mixture of nucleic acids, including the following steps: a) subjecting the mixture of nucleic acids to a physico-chemical separation step, thereby obtaining a set of mixed fractions containing the nucleic acids, a run parameter window being associated with every mixed fraction containing the nucleic acids, b) contacting a mixed fraction containing the nucleic acids with the target molecule, thereby obtaining a binding mixture containing nucleic acid/target molecule complexes, c) subjecting the binding mixture from step b) to the same physico-chemical separation step as in step a), thereby selecting nucleic acid/target molecule complexes whose run parameters are outside of the run parameter window.
Patent PT-1370781-E (PT)
Title: Shaft coupling
Inventor: BACSKAY ISTVAN
IPC: F16D1/04
Filed: 2002-03-22
Abstract: In a shaft coupling having a pair of complementally shaped, detachably joinable coupling sleeve halves ( 11, 12 ) which can be clamped together by means of clamping elements to form a split coupling sleeve provided with at least one seat ( 14 ) for a first shaft member (A 1 ) which is to be non-rotatably connected with a second shaft member (A 2 , A 2 ') so that the first and second shaft members are aligned. The sleeve halves include retaining elements for positively locking the first shaft member (A 1 ) against rotational movement relative to the coupling sleeve, wherein the retaining elements include a plurality of elongate force transmitting elements ( 16 D) in the seat ( 14, 15 )
Patent PT-1408118-E (PT)
Inventor: JAVIER CANADA VICINAY FRANCISC
IPC: B01D9/02
Filed: 2002-06-14
Abstract: In the preparation of 4-O-beta -D-galactopyranosyl-D-xylose (I) by reacting D-xylose, a beta -galactopyranoside substrate and beta -D-galactosidase (BDG) in aqueous buffer, (I) is isolated (after deactivating or removing the BDG and removing the substrate aglycone) by adding celite, carrying out solid-liquid extraction and eluting from a column, and (I)-containing fractions are treated by crystallization. Preparation of 4-O-beta -D-galactopyranosyl-D-xylose (I) involves: (i) treating a mixture of 2-20 wt.% D-xylose, 0.5-5 wt.% of a beta -galactopyranoside (as substrate) and 75-97.5 wt.% aqueous buffer of pH 5.0-9.0 (as reaction medium) with 10-1000 U (per g of substrate) of beta -D-galactosidase (BDG); (ii) carrying out disaccharide-forming reaction at a temperature between the freezing point of the mixture and 45[deg]C for 2-48 hours; (iii) deactivating the BDG by freezing at -20 to -170[deg]C or by heating at 95-115[deg]C or removing the BDG from the mixture by ultrafiltration; (iv) removing the aglycone of the substrate by extraction or filtration, and (v) isolating the (I)-containing fractions. Step (v) is carried out by adding celite, carrying out solid-liquid extraction with a solvent and eluting from a column with a first eluant, or by directly adding activated carbon, filtering and eluting with a second solvent. The (I)-containing fractions are further treated by crystallization from a mixture of acetone and methanol (or water) in a ratio of 5-20:1. An independent claim is included for (I) obtained by the process.
Patent PT-1425033-E (PT)
Title: Use of hcg and lh in controlled ovarian hyperstimulation
Inventor: MENEZO YVES
IPC: A61K9/16
Filed: 2002-09-12
Abstract: The invention provides a protocol leading to improved embryo implantation rates and/or decreased miscarriage rates in which hCG or LH, or a bio-analogue thereof, is administered during the follicular phase.
Patent PT-1446200-E (PT)
Title: Protective clothing against biological agents
Inventor: CERBINI STEFANO
IPC: A41D31/00
Filed: 2002-11-12
Abstract: The invention relates to overalls, manufactured by polypropylene and polyethylene, usable as protective clothing, in particular suitable as barrier against biological agents. The overalls provide a very high level of protection against the penetration of liquids and microorganisms, excellent mechanical properties, including tear and abrasion resistance, outstanding softness, drapeability and comfort.
Patent PT-1531862-E (PT)
Title: Stabilized liquid anti-rsv antibody formulations
Inventor: OLIVER CYNTHIA N
IPC: A61K47/26
Filed: 2003-06-16
Abstract: The present invention provides liquid formulations of SYNAGIS ®  or an antigen binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS® or an antigen-binding fragment thereof, even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides method of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention.
Patent PT-1695635-E (PT)
Title: Food preparation
Inventor: SONIA BOCCHI
IPC: A23L35/00
Filed: 2005-02-25
Abstract: Food preparation comprising a tomato sauce base and a plurality of rissoles containing at least one foodstuff chosen among fish, vegetables and legumes in an amount of at least 20% by weight of the total weight of said rissoles and optionally white meats, in particular chicken and/or turkey.
Patent PT-1814411-E (PT)
Title: Lipidic composition exhibiting interesting nutritional and organoleptic properties
Inventor: VIGNERON PIERRE-YVES
IPC: A23L27/60
Filed: 2005-11-17
Abstract: The invention relates to a lipidic composition containing more than 99 % of vegetable lipids, approximately from 45 to 67 % in weight rape-seed oil, equal to or more than 18 % in weight olive oil, from about 11 to about 24 % in weight vegetable oil containing from about 50 to about 80 % in weight linoleic acid and from about 20 to about 200 mg/100 g of a-topherol in such a way that the lipidic composition comprises from about 20 to about 35 mg/100 g of the a-topherol.
Patent PT-1847534-E (PT)
Title: Thiadiazoline derivatives for treating cancer
Inventor: MURAKATA CHIKARA
IPC: A61K31/4439
Filed: 2002-12-11
Abstract: (wherein R 1  and R 4  are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkenyl, or the like; R 5  represents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; R 2  represents -C(=W)R 6  or the like; R 3  represents a hydrogen atom, -C(=W A )R 6A  , or the like)  Antitumor agents which comprises a thiadiazoline derivative represented by the aforementioned general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient are provided.
Patent PT-2028015-E (PT)
Title: Recording sheet with improved image dry time
Inventor: KOENIG MICHAEL F
IPC: B05D5/00
Filed: 2006-10-11
Abstract: This invention is directed to an recording sheet having improved image dry time for use in printing comprising a substrate having in contact with at least one surface thereof one or more water soluble divalent metal salts, preferably admixed with one or more starches, to process of forming such recording sheet, to a method of generating one or more image(s) on said recording sheet in an printing process and to a recording sheet having one or more images on a surface thereof.
Patent PT-2272863-E (PT)
Title: Poa p 5-derivatives with reduced allergenicity and conserved t-cell reactivity
Inventor: FIEBIG HELMUT
IPC: C07K14/415
Filed: 2004-05-06
Abstract: Variants (A) of group 5 allergens of the Pooideae that have, relative to the wild-type allergen (B), reduced immunoglobulin E reactivity but essentially unchanged reactivity with T lymphocytes. Independent claims are also included for the following: (1) DNA (I) that encodes (A); (2) recombinant expression vector (EV) that contains (I) and functionally linked expression control sequences; (3) host organisms transformed with (I) or EV; and (4) preparation of (A) by culturing the organisms of (3). ACTIVITY : Antiallergic. No details of tests for antiallergic activity are given. MECHANISM OF ACTION : Immunotherapy (hyposensitization); Vaccine.
Patent PT-682494-E (PT)
Inventor: BRAIG JAMES R
IPC: G01N21/35
Filed: 1994-01-21
Abstract: A method and apparatus for monitoring glucose, ethyl alcohol and other blood constituents in a noninvasive manner. The measurements are made by monitoring infrared absorption of the desired blood constituent in the long infrared wavelength range where the blood constituent has a strong and distinguishable absorption spectrum. The long wavelength infrared energy is passed through a finger or other vascularized appendage and the measurement made. To prevent the high energy source from burning or causing patient discomfort, only short bursts or pulses of energy are sent through the finger with a very low duty cycle and low optical bandwidth. The bursts are further synchronized with systole and diastole of the cardiac cycle so that only two pulses are sent per heart beat, one during diastole and one during systole. The detection signals measured during application of these bursts of energy are then used to calculate the concentration of the blood constituents in accordance with a polynomial equation.
Patent PT-704219-E (PT)
Inventor: TAKIGAWA MASAHARU
IPC: A61K38/18
Filed: 1995-07-18
Abstract: This invention relates to a composition for metabolic bone diseaese and/or bone fractures which comprises a pharmaceutically acceptable carrier and human neurotrophin-3 (NT-3). This invention also relates to a method for the treatment and/or prevention of metabolic bone diseaese or bone fractures which comprises administering to a patient in need of said treatment and/or prevention a medicament containing an effective amount of human neurotrophin-3 (NT-3). <IMAGE>
Patent PT-764404-E (PT)
Inventor: MAEDA MASARU
IPC: A01N47/36
Filed: 1996-09-16
Abstract: A granular herbicidal composition which comprises 1-(4,6-dimethoxypyrimidin-2-yl)-3-(3-trifluoromethyl-2-pyridylsulfonyl )urea or a salt thereof as a herbicidal active ingredient, together with a chemical stabilizer and a carrier.
Patent PT-874853-E (PT)
Inventor: LEE GWAN SUN
IPC: C07D501/04
Filed: 1996-12-26
Abstract: PCT No. PCT/KR96/00250 Sec. 371 Date May 18, 1998 Sec. 102(e) Date May 18, 1998 PCT Filed Dec. 26, 1996 PCT Pub. No. WO97/24358 PCT Pub. Date Jul. 10, 1997The present invention relates to a novel crystalline cefdinir intermediate having formula (II) which can be used very usefully for preparing a cephalosporin antibiotics, cefdinir, in which Ph represents phenyl, p-TsOH represents p-toluenesulfonic acid, and DMAC represents N,N-dimethylacetamide, to a process for preparation thereof and to a process for preparing cefdinir using the compound of formula (II). According to the present invention, cefdinir can be prepared in an excellent color and purity and with a good yield.
Patent PT-929457-E (PT)
Inventor: INGEMAR NAESLUND
IPC: B65D85/72
Filed: 1997-07-08
Abstract: A substance packaging container, preferably for packaging a liquid or powder substance, includes a sealed first chamber (4) for the substance (6) to be packaged. The substance chamber (4) is comprised of a flexible material, such as a foil material. The container also includes a sealed, rigid second chamber (8) which is disposed inside the substance chamber (4).
Patent PT-857554-E (PT)
Inventor: BAUMANN FRITHJOF
IPC: B29C33/04
Filed: 1998-02-05
Abstract: Moulds and tools, especially for plastic processing, are provided with fine precision spot temperature control by means of an internal temperature control medium within an arterial temperature control structure in the form of an arterial vascular system coupled to one or more temperature control medium feed and return lines. Also claimed is a method of temperature controlling the above moulds and tools in which a temperature control medium is circulated through the arterial vascular system by means of feed and return lines.
Patent PT-961711-E (PT)
Inventor: SICILIANO VITO
IPC: B60M1/10
Filed: 1998-02-20
Abstract: A power line (1) wherein an elongated enclosure (4) houses a first and a second conducting line (27, 23), a striplike base portion (63) made of ferromagnetic material, an electric contact portion (71) superimposed on the base portion (63), and a releasable connecting device (64, 72) for connecting the base portion and the electric contact portion. The releasable connecting device (64, 72) permits disconnection of the striplike base portion (63) in the event a portion of the electric contact portion (71) remains in the raised position following extinction of the magnetic field, so that the base portion (63) drops down and establishes a short-circuit connection, indicating a malfunction, between the first and second conducting lines (27, 23).
Patent PT-961693-E (PT)
Inventor: COBBEN JOHANNES IGNATIUS MARIE
IPC: B42D15/10
Filed: 1998-02-18
Abstract: The invention relates to a fraud-proof document comprising a carrier and at least one marking arranged on the carrier, wherein at least a part of the surface of the marking or along at least a part of the periphery of the marking a weakening pattern is arranged in the carrier which, when detached, results in a permanent an easily visible distortion of the pattern. When removing the glued-on passport photo or foil a forger will irrevocably distort the weakening pattern, this such that the regularity is permanently and visibly disturbed so that it is easy to ascertain that the document in question has been subjected to an attempted fraud.
Patent PT-963294-E (PT)
Inventor: DEPOND BERNARD
IPC: B41F13/02
Filed: 1998-02-18
Abstract: The invention concerns a flexographic printing machine comprising a plurality of printers (2) and so-called feeding and tension means, for unwinding under tension and successively in each of the printers a strip-packed base stock to be printed (8), characterised in that each of the printers (2) is provided with said feeding and tension means (4, 6, 52) of the strip to be printed (8), comprising at least a fifth so-called support roll (4), movable (arrow 7) in the direction of a motoring roll of the printer (2), said motoring roll being any one roll of the roll unit comprising an impression cylinder (14) and the bar feeders (16, 18, 20, 22) such that the variations in tension of the strip (8), and therefore in strip length, inside a printer (2) are not passed on to the following printer (2).
Patent PT-991889-E (PT)
Inventor: MORETTI ERMINIO
IPC: F16L37/084
Filed: 1998-06-09
Abstract: A detachable, quick-fitting pipe union for receiving a plug-in tubular part (3) with a circumferential holding rib (4) consists of a cylindrical housing (1) into which the plug-in part (3) is inserted and of a separate holding spring (2) with elastic, resilient holding edges (17) which hook the holding rib (4) from behind after the plug-in part (3) is pushed in. Outwardly projecting supporting bodies (13) are shaped on the holding edges (17) and engage corresponding recesses (12) of the housing wall (5) in the assembled state for securing the holding springs (2) in the axial direction. In order to increase the retaining force in the housing (1), the front faces (21) of the supporting bodies (13) are outwardly slanted in the plug-in direction against the vertical plane in the region where they abut on the inner edge (22). In order to limit the resulting bending outwards of the housing wall (5) in the region of the opening, radially projecting stop surfaces (23, 24) are provided on the slanting front faces (21) outside the supporting region. These stop surfaces (23, 24) prevent the front housing wall (5) from further bending outwards when strong tensile forces arise.
Patent PT-1053017-E (PT)
Inventor: MISHKIN ERIC M
IPC: A61K39/39
Filed: 1999-02-10
Abstract: This invention pertains to vaccine compositions comprising a mixture of antigen, such as a herpes simplex virus antigen, and the interleukin IL-12, which may be adsorbed onto a mineral in suspension. These vaccine compositions modulate the protective immune response to the antigen.
Patent PT-1075492-E (PT)
Title: Melanocortin 1 receptor selective compounds
IPC: C07K19/00
Filed: 1999-05-05
Abstract: A compound of the general formula (1):   
wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are H or methyl, R13, R14, R15 and R16 are H or alkyl, wherein L1 and L2 are linkers selected from single bond, methyl, ethyl, wherein R19, R20 and R21 are H or -CH 2 X, NT is selected from H, hydroxyl, alkyl, aminoacid, aminoacid analogue, polypeptide and functional group, CT is selected from hydrogen, hydroxyl, alkyl, aminoacid, aminoacid analogue, polypeptide and functional group shows high selectivity and high affinity for MC1-receptors in combination with effective stimulation or inhibition of cAMP formation in MC1-receptor expressing cells but low affinity for other subtypes of MC-receptors and may be used to treat a wide range of inflammatory conditions. Also disclosed is a DNA molecule and a corresponding vector encoding the compound, a fusion protein comprising a copy of it, a vector comprising DNA encoding the fusion protein, and a pharmaceutical composition comprising the compound.
Patent PT-1140522-E (PT)
Inventor: CARRIER JEAN-MICHEL
IPC: B65D85/57
Filed: 1999-10-21
Abstract: A multi-sleeve booklet (80) and a blank for forming a multi sleeve booklet for holding discs or the like, which booklet comprises a plurality of sleeves joined in series and folded upon each other in overlapping relationship. A panel (66) forming the spine of the booklet and for hingedly joining all the sleeves (42) together is joined to one of the opposed outermost sleeves and secured to the other outermost sleeve (32).
Patent SG-98392-G (SG)
Title: Hydraulic device for the injection unit of a plastic material injection-moulding machine
IPC: B29C45/82
Filed: 1992-09-29
Abstract: A hydraulic control system for the operation of three linear and one rotary hydraulic drive assemblies of the injection unit of an injection molding machine, comprising a variable delivery pump supplying drive fluid at a constant pressure gradient to several supply lines controlled by two control units which are arranged in parallel and feature proportional P/Q valves and pressure transducers, a smaller pressure maintenance pump which is controllable by a third proportional P/Q valve and switchable into one of the supply lines, and a hydraulic accumulator for the temporary supply of a large quantity of drive fluid. The proportional P/Q valves convert automatically from their flow rate programs, controlled by displacement-to-voltage converters on the injection unit, to pressure programs controlled by the pressure transducers.
Patent IE-790227-L (IE)
Title: Nematicidal compositions
IPC: A01N25/22
Filed: 1979-02-06
Abstract: "Stabilized granular nematicidal and insecticidal composition having O-ethyl-S,S-dipropyl dithiophosphate as an active substance." …<??>The invention relates to a stabilized granular nematicidal and insecticidal composition having O-ethyl-S,S-dipropyl dithiophosphate as an active substance which contains pumice granules as a stabilizing carrier. 
[EP0004393A1]
Patent IE-32746-L (IE)
Title: Pharmaceutical preparation
IPC: A61K38/48
Filed: 1969-03-11
Abstract: 1,265,387. Pharmaceutical composition. BEHRINGWERKE-A.G. 21 March, 1969 [23 March, 1968], No. 14963/69. Heading A5B. A pharmaceutical composition comprises thiamine hydrochloride, ascorbic acid, invert sugar, tropin and a snake venom, the amount of tropin not exceeding 10% by volume based on the thiamine hydrochloride, ascorbic acid, invert sugar and tropin.
[GB1265387A]
Patent IE-820364-L (IE)
Title: Process for the preparation of 3-picoline
IPC: C07D213/10
Filed: 1982-02-22
Abstract: Process for the production of 3-picoline. A first educt consisting of acetaldehyde and/or acetaldehydeacetals and/or crotonaldehyde is reacted with a second educt consisting of formaldehyde and/or formaldehydeacetals and/or hexamethylenetetramine. The reaction is conducted in a liquid, aqueous phase at a temperature of 180 DEG  to 280 DEG  C. in a closed vessel in the presence of an amide of a carboxylic acid.
Patent IE-39216-L (IE)
Title: Pharmaceutical tablets
IPC: A61P31/04
Filed: 1974-04-17
Abstract: 1422176 Pharmaceutical tablets BEECHAM GROUP Ltd 1 May 1974 [5 May 1973 7 Dec 1973] 21502/73 and 56858/73 Heading A5B Pharmaceutical tablets comprise 10% to 70% by weight of heavy magnesium carbonate, 30% to 85% by weight of a semi-synthetic penicillin or cephalosparin which is suitable for oral administration and 0 to 40% by weight of conventional tabletting ingredients. The tablets may be produced by direct compression in a tablet press. Two different penicillins may be present in the tablets. The penicillins and cephalosparins may be cloxacillin, flucloxacillin, dicloxacillin, an α-ester of carbenicillin or ticarcillin, phenethicillin, propacillin, azidocillin, hetacillin, metampicillin, cyclocillin, epicillin, pivampicillin, talampicillin, cephalexin, cephadrine, ampicillin, amoxycillin and esters and salts thereof.
[GB1422176A]
Patent IE-830861-L (IE)
Title: Equine influenza vaccine.
IPC: A61K39/00
Filed: 1983-04-15
Abstract: A method and resulting temperature-sensitive (ts) reassortant virus produced by modifying wild-type equine influenza viruses by utilizing mutagenized human influenza viruses possessing ts lesions and shut off temperatures in the area of 37<o>-39<o> C, preferably 37<o>-38<o> C. When utilized as a vaccine for equines, these temperature-sensitive recombinant viruses have the facility to develop only mild symptoms while producing protection against infectious equine influenzal disease.
[WO8303546A1]