Patent SG-11201407818P-A (SG)
Title: High-capacity storage of digital information in dna
Inventor: GOLDMAN NICK
IPC: G06N3/12
Filed: 2013-05-31
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau „ (10) International Publication Number (43) International Publication Date ^ ^ WO 2013/178801 A3 5 December 2013 (05.12.2013) WIPO I PCT (51) International Patent Classification: G06F19/22 (2011.01) G06N3/12 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/EP2013/061300 31 May 2013 (31.05.2013) English English (30) Priority Data: 61/654,295 1 June 2012 (01.06.2012) (71) Applicant: EUROPEAN MOLECULAR BIOLOGY LABORATORY [DE/DE]; Meyerhofstr. 1, 69117 Heidel­ berg (DE). (72) Inventors: GOLDMAN, Nick; European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cam­ bridge Cambridgeshire CB10 1SD (GB). BIRNEY, John; European Bioinformatics Institute, Wellcome Trust Gen­ ome Campus, Hinxton, Cambridge Cambridgeshire CB10 1SD(GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Ug (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (74) Agent: 24IP LAW GROUP SONNENBERG FORT- MANN; Patent- und Rechtsanwalte, Dr. Robert Harrison, HerzogspitalstraBe 10a, 80331 Miinchen (DE). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) [Continued on next page] (54) Title: HIGH-CAPACITY STORAGE OF DIGITAL INFORMATION IN DNA binary/text file I --.00011001110011100110011000010111010101011111... I | ^Thoui«^morelovel^_and_jriore_tem£erate ^^__| i . TAGATGTGTACAGACTACGCGCAGCGAGATCGACTCGCAGTGCTGAGTGACAGACTAGTCACGTCGCAGCGCTAG 1 I I alternate fragments have file information alemented T-H o 00 00 l> T-H rn T-H o CJ O ^ d DNA-encoded indexing information added Figure 2 (57) Abstract: A method for storage of an item of information (210) disclosed. The method comprises encoding is bytes (720) in the item of information (210), and representing using a schema the encoded bytes by a DNA nucleotide to produce DNA sequence a (230). The DNA sequence (230) is broken into a plurality of overlapping DNA segments (240) and indexing information (250) ad­ ded to the plurality of DNA segments. Finally, the plurality of DNA segments (240) is synthesized (790) and stored (795). WO 2013/178801 A3 I lllll llllllll II llllll III lllll lllll lllll lllll III III III lllll lllll llll lllll lllllll llll llll llll (88) Date of publication of the international search report: 23 January 2014