Patent AU-2020444034-B2 (AU)
Title: Nanoliter spray-FTICR-MS analysis method and device for organic matter dissolved in environmental solid sample
Inventor: GAN SHUCHAI
IPC: G01N27/62
Filed: 2020-12-31
Granted: 2022-12-01
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(54) Title: NANOLITER SPRAY-FTICR-MS ANALYSIS METHOD AND DEVICE FOR ORGANIC MATTER DISSOLVED IN 
ENVIRONMENTAL SOLID SAMPLE 
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(57) Abstract: A nanoliter spray-FTICR-MS analysis method and device for organic matter dissolved in an environmental solid sample.  
The device comprises a nanoliter spray device and a Fourier transform ion cyclotron resonance mass spectrometer, wherein the nanoliter 
spray device comprises a glass spray head (1), a conductive needle (2), a switching rubber head (4), a duplex pressurizing ball (5), and 
a gas storage bag (6). The sample solution loaded by the glass spray head (1) is a mixed solution composed of interstitial water and 
an organic solvent, and a nozzle is aligned with a sample inlet of the Fourier transform ion cyclotron resonance mass spectrometer.  
The nanoliter spray device is used in combination with the Fourier transform ion cyclotron resonance mass spectrometer (FTICR-MS), 
which does not purify and enrich samples by means of solid phase extraction, but instead improves the ionization efficiency and reduces 
ion selective inhibition by means of changing the matrix formula and the nanoliter spray. Direct analysis of interstitial water in an 
C environmental solid sample can be realized, and the key problems that, in the prior art, bioactive molecule signals need to be lost by 
means of a solid-phase extraction pretreatment, and common electrospray source selective signal inhibition is needed are solved.
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