baber/WOPTO huggingface dataset:
Patent HR-P20120071-T1 (HR)
Title: (1-AZA-BICYCLO[3.3.1]N0N-4-YL)-[5-(1H-INDOL-5-YL)-HETEROARYL]-AMINES AS CHOLINERGIC LIGANDS OF THE N-AChR FOR THE TREATMENT OF PSYCHOTIC AND NEURODEGENERATIVE DISORDERS
Inventor: FREDERIKSEN MATHIAS
IPC: C07D471/08
Filed: 2012-01-23
Abstract: The present invention relates to compounds of formula (I)   
wherein 
n represents 0, 1, 2, 3, 4 or 5, 
R represents independent from each other hydroxyl, cyano, nitro, halogen, alkyl, alkoxy alkylcarbonyl, alkoxycarbonyl, alkylamine, dialkylamine, alkylcarbonylamine, alkylcarbamate 
Y represents one of the following groups:   
in free base or acid addition salt form, to processes for their production to pharmaceutical compositions comprising them and for use as cholinergic ligands of n-AChR.
Patent HR-P20181204-T1 (HR)
Title: ANTIGEN BINDING MOLECULES WITH INCREASED Fc RECEPTOR BINDING AFFINITY AND EFFECTOR FUNCTION
Inventor: UMANA PABLO
IPC: C12N15/63
Filed: 2018-07-25
Abstract: The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human CD20. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention, and to methods of using these ABMs in treatment of disease. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
Patent SI-1487810-T1 (SI)
Title: 4-(diarylmethyl)-1-piperazinyl derivatives
Inventor: MIDHA AJAY SOHANLAL
IPC: C07D295/08
Filed: 2003-03-27
Abstract: A compound of formula I wherein X, Y, X' & Y' are selected from hydrogen, halogen, substituted or unsubstituted alkyl (linear, branched or cyclo), aryl, alkyloxy and haloalkyl group; R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3 </SUB>& R<SUB>4 </SUB>are selected from hydrogen, substituted or unsubstituted alkyl groups (linear, branched or cyclo), aryl, heteroaryl groups or aralkyl groups, heterocycles containing one or more of hetero atoms (viz., N, S, O), substituted or unsubstituted alkenyl or alkynyl groups of carbon 2 to 6; wherein the substituents R<SUB>1 </SUB>& R<SUB>2 </SUB>on the piperazinyl moiety are either syn or anti to each other and optionally R<SUB>3 </SUB>and R<SUB>4 </SUB>together with the carbons to which they are attached form a monocyclic saturated or aryl or substituted aryl or heteroaryl or substituted heteroaryl ring containing one or more hetero atoms selected from N, S and O with a ring size ranging from 3 to 6; with a proviso that when R<SUB>3 </SUB>& R<SUB>4 </SUB>together do not form part of a ring they may exist in either E or Z configuration; R<SUB>5 </SUB>is (CH<SUB>2</SUB>)<SUB>n</SUB>-O-CH<SUB>2</SUB>-CO-Z wherein n is 1 to 6; Z is selected from OH, OR, NRR', N(OR)R', N(R)-N(R)R'and wherein R & R' are selected from hydrogen, substituted or unsubstituted alkyl groups (linear, branched or cyclo), aryl, heteroaryl groups or aralkyl groups, heterocycles containing one or more of hetero atoms (viz., N, S, O), substituted or unsubstituted alkenyl or alkynyl groups of carbon 2 to 6; and B is selected from -(CH 2 )n-(n is 1 to 6) and -(CH 2 )x-D-(CH 2 )y where D is O, NR, S or SO 2 , x and y are independently 1 to 6; and m is selected from 1 to 6; and pharmaceutically acceptable salts thereof.
Patent SI-2935307-T1 (SI)
Title: Neuroactive 19-alkoxy-17-substituted steroids, useful in methods of treatment
Inventor: COVEY DOUGLAS
IPC: C07J9/00
Filed: 2013-12-18
Abstract: The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.
Patent SI-3019756-T1 (SI)
Title: Structural assembly and method of assembly thereof
Inventor: GAFNI IZHAR
IPC: F16B17/00
Filed: 2014-07-02
Abstract: Assemblies comprising first and second assembly members attached to one another via a connection arrangement and methods for forming such assemblies.
Patent DE-3650175-T2 (DE)
Inventor: COSAND WESLEY
IPC: G01N33/569
Filed: 1986-04-21
Granted: 1995-06-14
Abstract: Novel peptides are provided having substantially the same sequence as immunologically significant fragments of AIDS-related viruses. The polypeptides can be used as reagents in the determination of exposure of a human host to the virus. Of particular interest is the use of polypeptides in screening blood products.
Patent DE-3688873-T2 (DE)
Inventor: GILDING D KEITH
IPC: A61F2/06
Filed: 1986-10-16
Granted: 1994-03-10
Abstract: A microporous biocompatible material is formed by pre­paring a segmented polyether urethane urea solution containing 25% ± 1.5% solids dissolved in a solvent. The solution has sufficient viscosity to be preshaped and formed into the desired thickness of the finished article, then immediately immersed into a precipitation bath in which the solvent in the solution is miscible for a time interval sufficient to cause the solution to set up into an opaque elastomeric article. The article is immediately removed from the bath, any excess solvent extracted and then dried at a temperature on the order of 35°C. to 70°C. followed by heat treating by annealing for approximately sixty minutes at a temperature at 100°C. to 130°C. The void volume of the membrane solution is controlled to within the 50% to 80% range and the pore size from ca <0.1 to several mms. as well as the shape of the pores and solid structures between them, thereby enabling close control over the characteristics and structure of the material as well as other variations in structural characteristics and porosity across the thickness of the material according to its intended application and use.
Patent DE-3750993-T2 (DE)
Inventor: AASEN STEVEN M
IPC: A61K6/884
Filed: 1987-02-25
Granted: 1995-08-03
Abstract: An acid and a water-soluble film former are used as a primer for hard tissue (e.g., dentin). The acid has a pK<sub>a</sub> less than or equal to that of phenol and the acid and its calcium salt(s) are soluble in the film former. The primer is free of adhesively detrimental quantities of calcium salts that are not soluble in the film former.
Patent DE-3784313-T2 (DE)
Inventor: LARSEN HERLUF JAKOB
IPC: B62J6/02
Filed: 1987-11-13
Granted: 1993-06-24
Abstract: A light system for a vehicle, in particular a bicycle, with a number of lamps, a rechargeable battery (10) and a circuit with controlling and contact means being adapted to automatically switch on and switch off, respectively, the lamps (32,34) dependent on surrounding light conditions being provided with sensor means (16) being adapted to register that the bicycle is in use and being cooperating with a light sensor (12) belonging to said circuit. Hereby is obtained in a simple manner important advantages in use which is of special importance concerning the the necessary capacity of the rechargeable battery and also the automatical function of the light system gives this a new dimension in use by using the new parameter that the bicycle has to be in normal use in order to switch on the lamps of the light system.
Patent DE-3785577-T2 (DE)
Inventor: UBER E III
IPC: G01T7/12
Filed: 1987-12-08
Granted: 1993-10-07
Abstract: A dosimeter (10) that includes tissue equivalent bubbles of plastic defining volumes of gas to be ionized by radiation. One or more integrated circuits (ICs) are disposed below the volumes of gas and a collecting electrode on the IC is in direct contact with the gas. Circuitry (18) for generating an electric field within the volume of gas moves the ions therein to the collecting electrode. The collecting electrode is part of an amplifying circuit (20) disposed within the IC. The output from the amplifier (20) is representative of the collected ions and therefore representative of the radiation. The signal from the amplifier (20) is sent to an interface (14) which conditions, buffers and stores the signal. The radiation dose and dose rate are computed in the interface at (30). A communications section (36) transfers that data from the dosimeter upon receipt of an externally generated data transfer command. A separate calibration (34) and display unit (31) calibrates the dosimeter (10) by controlling the conditioning of the signal.
Patent DE-3789867-T2 (DE)
Inventor: RAYCHAUDHURI SATYABRATA
IPC: C23C16/26
Filed: 1987-03-31
Granted: 1994-10-06
Abstract: A method for hermetically sealing a silica based fiber product after the fiber product has been drawn from a melt or preform wherein a hermetic layer of boron carbide or a ceramic compound having a density of above about 4 g/cc is deposited upon the fiber product. The fiber product can be initially coated with carbon or boron carbide prior to the application of the ceramic compound. Also, a method for making such fiber products using these methods, and the resultant hermetically sealed fiber products produced thereby.
Patent DE-3850267-T2 (DE)
Inventor: ORKIN FREDERIC IRWIN
IPC: A61M39/02
Filed: 1988-08-05
Granted: 1995-02-02
Abstract: A multiple fluid delivery apparatus is provided for delivering intravenous fluids to a patient in a composite fluid flow from a plurality of fluid sources (56a,56b,56c). Electrically operated occluders (64a,64b,64c) are actuated to control fluid flow from the sources to a junction (70) where little or no mixing occurs. A predetermined delivery schedule is programmed into a controller (102,142), which controls the administration by actuation of the occluders. The controller stores information on fluid compatibility and an indicium of compatibility is visually displayed before the occluders are actuated. <IMAGE>
Patent DE-3851208-T2 (DE)
Inventor: LABEDZ GERALD PAUL
IPC: H04B7/005
Filed: 1988-10-17
Granted: 1995-03-09
Abstract: The method and apparatus for rapid phase acquisition and random radio channel phase error compensation for a TDMA QPSK receiver is disclosed. Received quadrature signals having a known synchronizing sequence transmitted on one of the vectors is correlated to a local replica of the sequence. The output correlation detection signals are held for the duration of the TDMA timeslot and multiplied by the received quadrature signals to produce two pairs of products. The mutually exclusive product pairs are summed to recover data having the random phase error compensated.
Patent DE-3852961-T2 (DE)
Inventor: BONI LAWRENCE
IPC: A61K9/127
Filed: 1988-03-04
Granted: 1995-07-06
Abstract: Methods and compositions are described for nonliposomal lipid complexes in association with toxic hydrophobic drugs such as the polyene antibiotic amphotericin B. Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio. The lipid complexes contain a bioactive agent, and may be made by a number of procedures, at high drug:lipid ratios. These compositions of high drug:lipid complexes (HDLCs) may be administered to mammals such as humans for the treatment of infections, with substantially equivalent or greater efficacy and reduced drug toxicities as compared to the drugs in their free form. Also disclosed is a novel liposome-loading procedure, which may also be used in the formation of the HDLCs.
Patent DE-3854205-T2 (DE)
Inventor: HANEISHI TATSUO
IPC: C07D405/04
Filed: 1988-11-16
Granted: 1996-04-04
Abstract: New antibiotics of the mureidomycin group have the formula <CHEM>  wherein X represents the group <CHEM> and wherein R represents a hydrogen atom, an alkyl group having from 1 to 10 carbon atoms, an alkenyl group having from 2 to 7 carbon atoms, an alkynyl group having from 3 to 7 carbon atoms, an aryl group having from 6 to 10 carbon atoms, an aralkyl group having from 7 to 10 carbon atoms, or one of the said aryl or aralkyl groups substituted with at least one halogen atom and/or at least least one alkyl group having from 1 to 5 carbon atoms. The compound in which X represents 8-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl is named mureidomycin E and the compound in which X represents 6-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl is named mureidomycin F. This group of compounds and their pharmaceutically acceptable esters and salts are useful as antibiotics for the treatment of bacterial infections. Mureidomycins E and F can be obtained by fermentation of a suitable Streptomyces strain, in particular Streptomyces flavidovirens SANK 60486 (BIKOKEN JOHKI 1347; FERM BP-1347). ALternatively, all of the compounds can be obtained synthetically by reacting the previously known compound mureidomycin A with an aldehyde of the formula R - CHO.
Patent DE-3871555-T2 (DE)
Inventor: VAN DEN BERG JOHANNES PETRUS
IPC: C07C7/148
Filed: 1988-03-02
Granted: 1992-12-03
Abstract: Process for two-stage catalytic conversion of an olefins-containing feed by contacting the feed in a first stage under substantially non-oligomerizing conditions with a catalyst comprising at least one metal (X) selected from the group consisting of metals from Groups 1a, 1b, 2a, 2b, 4b, 5b, 6b and 8 of the Periodic Table of the Elements and contacting effluent from the first stage in the second stage under olefin oligomerization conditions at a temperature which is at least 50  DEG C above the operating temperature of the first stage with a catalyst comprising at least one metal (Z) selected from the group consisting of metals from Groups 1b, 2a, 2b, 4b, 5b, 6b and 8 on a mordenite-type of crystalline trivalent metal (Q) silicate.
Patent DE-3873109-T2 (DE)
Inventor: WILLIAMS RICHARD STUART
IPC: C08K7/14
Filed: 1988-02-02
Granted: 1993-03-11
Abstract: A moulding composition based on a thermoplastic polyamide contains red phosphorus and magnesium carbonate for flame retardancy with a good electrical tracking resistance. The composition can also include reinforcing fibres. The amounts of red phosphorus and magnesium carbonate may be 5 to 15 per cent by weight and 5 to 50 per cent by weight of the composition respectively, their combined total being not more than 55 per cent by weight of the composition. The amounts of red phosphorus and magnesium carbonate are such that      3P + C >/= 30 where P is per cent by weight red phosphorus and C is per cent by weight magnesium carbonate in the total composition.
Patent DE-3875466-T2 (DE)
Inventor: LASSIAZ CHARLES
IPC: B01D9/00
Filed: 1988-12-21
Granted: 1993-03-04
Abstract: Device for the purification of any crystallisable organic, inorganic, aqueous or other product comprises, essentially, a refiner (2) fitted with one or more heat exchangers (3) with spiral enclosures. In order to make this device a multipurpose one, each of the heat exchangers (3) which it comprises constitutes a module (30, 31, 32, 33) provided, on the one hand, with connecting means (34) enabling them to be superposed merely by assembly while retaining their autonomy with regard to the entries and exits of crystallisable products, this module (30, 31, 32, 33) comprising, on the other hand, means for feeding and/or removing (28, 29) the transfer fluid of one of the spiral enclosures situated outside the heat exchanger (3), the number of these modules (30, 31, 32, 33) making up the said device being variable. <IMAGE>
Patent DE-3880668-T2 (DE)
Inventor: WILES MARTIN
IPC: G01N27/333
Filed: 1988-11-14
Granted: 1993-08-05
Abstract: PCT No. PCT/GB88/00992 Sec. 371 Date Sep. 25, 1989 Sec. 102(e) Date Sep. 25, 1989 PCT Filed Nov. 14, 1988 PCT Pub. No. WO89/04958 PCT Pub. Date Jun. 1, 1989.An electrochemical reference element is proposed having a metal electrode such as silver coated with the tetraphenyl (TPB) salt of the metal. The element may form the internal reference of an ion selective electrode with an ion selective membrane carried directly upon the TPB coating. The element provides a thermodynamically reversible couple suitable for use in a non-aqueous environment.
Patent DE-60005839-T2 (DE)
Inventor: BOECKH DIETER
IPC: C08G65/329
Filed: 2000-07-05
Granted: 2004-05-06
Abstract: A zwitterionic polyamine comprising a linear or branched hydrophobic polyamine backbone having 2 to 10 tertiary amino nitrogen atoms and a spacer between two tertiary nitrogen atoms wherein the spacer is, for example selected from C8-C16-alkylene, C5-C15-cyloalkylene, wherein in formula (IV) R = C1- to C22-alkyl or C7-C22-aralkyl and n = 3 to 6, at least one tertiary amine end group of the polyamine backbone contains two groups having formula (V) or (VI), wherein A means an ethylene oxide unit, a propylene oxide unit, a unit of butylene oxides and a tetrahydrofuran unit, n is a number of from 1 to 50, X is an anionic group such as -SO3M, with the proviso that in formula (VI) one X may also be hydrogen and M is hydrogen, alkali metal or ammonium, or contains one group of formula (V) or (VI) and one group selected from radicals consisting of formula (VII), C1- to C22-alkyl and C7-C22-aralkyl, the meaning of A and n is the same as in formula (V) or (VI), said zwitterionic polyetherpolyamine having a molecular weight up to 9000 and optionally containing up to 100 % of the nitrogen atoms quaternized, and a process for the production of zwitterionic polyamines by alkoxylating said polyamines, introducing anionic groups into the alkoxylated polyamines and optionally quaternizing them before or after the introduction of anionic groups. The zwitterionic polyamines are used in detergents.
Patent DE-60013129-T2 (DE)
Inventor: KIM KWANG-CHUL
IPC: H04L27/00
Filed: 2000-06-15
Granted: 2005-08-18
Abstract: A frequency and symbol timing synchronization apparatus for orthogonal frequency division multiplexed (OFDM) signals, and a method performed by the apparatus are provided. This apparatus includes an autocorrelation unit, a comparator, a peak flat detector, a frequency offset estimator, a frequency offset compensation unit, a cross correlation unit and a symbol timing synchronization unit. The autocorrelation unit receives data including a synchronizing symbol made up of at least three identical synchronizing signals, delays the received data by a predetermined delay amount, performs autocorrelation between the received data and the delayed data, normalizes an autocorrelated value, and outputs a normalized autocorrelated value. The comparator compares the normalized autocorrelated value with a predetermined threshold value. The peak flat detector detects as a flat section a section where the normalized autocorrelated value is equal to or greater than the threshold value. The frequency offset estimator estimates a frequency offset within the flat section to obtain a frequency offset value. The frequency offset compensation unit compensates for the frequency offset of a received signal using the frequency offset value. The cross correlation unit performs cross correlation using a frequency offset-compensated signal and a reference signal, and normalizes the cross-correlated value to output a normalized cross-correlated value. The symbol timing synchronization unit detects a point where the cross-correlated value is maximum, and performs symbol timing estimation, thereby performing symbol timing synchronization. In the symbol timing and frequency synchronization apparatus and method, accurate frequency synchronization can be achieved because a large sample error can be allowed. Also, a symbol timing error can be reduced since symbol timing synchronization is achieved using a frequency offset-compensated signal.
Patent DE-60017913-T2 (DE)
Inventor: CODOLAR SANTIAGO ARIAS
IPC: C09D157/06
Filed: 2000-06-09
Granted: 2006-01-12
Abstract: The present invention relates to a self-polishing marine antifouling paint composition comprising i) at least one binder co-polymer containing repeat units comprising acid-functional groups, e.g., carboxylic acid or sulfonic acid groups, said acid-functional groups being blocked by a blocking group, X, selected from the group consisting of monoamine groups, diamine groups, polyamine groups and quaternary ammonium groups; and ii) fibres. The composition shows improvement of the properties with respect to integrity of the paint film after long term use and in particular when exposed to alternate dry and wet.
Patent DE-60018271-T2 (DE)
Inventor: COSTER DOMINIQUE
IPC: B32B17/10
Filed: 2000-04-12
Granted: 2006-01-12
Abstract: The invention relates to glazings adapted for automotive vehicle roofs. The glazing according to the invention comprises:a first sheet of glass on the external face of the roof;a second sheet of glass at at least a portion of the internal surface arranged towards the interior;an intermediate sheet of one or more traditional thermoplastic materials used for forming laminated glazings, which extends at least over the surfaces of the sheet of glass which face each other;functional non-transparent elements arranged under the first sheet of glass;the transparent laminated portion having a luminous transmittance of less than 35 percent and an energy transmittance less than 20 percent.
Patent DE-60018639-T2 (DE)
Inventor: MCKEIGUE KEVIN
IPC: B01J19/30
Filed: 2000-06-23
Granted: 2006-02-09
Abstract: The present invention provides a structured packing (2) comprising a plurality of corrugated sheets (62,64) and a plurality of flat, planar members (70,72) alternating with and located between the sheets to inhibit turbulence in vapour ascending through the structured packing. The plurality of planar members (70,72) are positioned so that at least the lowermost horizontal edge of the planar members and the corrugated sheets (62,64) are situated proximal to one another as viewed when said structured packing is in use. When the planar members have substantially the same length (L) and width (W) as the corrugated sheets (62,64), the planar members (70,72) and the corrugated sheets have perforations (76) sized to inhibit transverse liquid and vapour flow while but allowing transverse pressure equalization through the structured packing. The size and number of perforations (76) can be optimized for air separation applications.  <IMAGE>
Patent DE-60020355-T2 (DE)
Inventor: GAUTSCHI MARKUS
IPC: C07D309/10
Filed: 2000-06-19
Granted: 2006-01-26
Abstract: The present invention refers to fragrance precursors of formula I   <CHEM>  for a fragrant ketone of formula II <CHEM>  and a fragrant lactone of formula III. <CHEM>   The substituents in this formula are defined in claim 1. These fragrance precursors are useful in perfumery, especially in the fine and functional perfumery.
Patent DE-60025093-T2 (DE)
Inventor: FOSTER DAVID GRAHAM
IPC: A47K10/16
Filed: 2000-03-15
Granted: 2006-08-24
Abstract: The present invention provides methods and devices for personal cleaning and, in particular, for cleaning and/or drying following defecation or urination, or for cleaning and freshening during menstruation.Devices according to the invention are unitary, in the sense that they do not require any configuring or formatting prior to use, and have two distinct zones of varying functional performance, one zone being configured with the principal objective of absorbing and retaining faeces, urine or menses, and the other zone being configured with the principal objective of protecting the user's hand.The devices drape over the user's hand and can be manipulated into body crevices.
Patent DE-60025539-T2 (DE)
Inventor: DOSHI PRAFUL
IPC: G02C7/04
Filed: 2000-10-23
Granted: 2006-07-27
Abstract: The present invention recognizes that lenses, such as contact lenses, can be pigmented using ink that include polymers or polymerizable monomers, preferably the same monomers used to make the lens. The ink can be used to make images on or within the lens. Images made using these inks are preferably digital and can be used in a variety of printing methods, including ink-jet printing.