Patent SG-11201807365Q-A (SG)
Title: a-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF
Inventor: OJIMA IWAO
IPC: C07D309/06
Filed: 2017-03-10
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111110111101110101011111010111110111011111011011101110011111111101111011111 International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ...... ... WO 2017/156354 Al 14 September 2017 (14.09.2017) WIP0 I PCT (51) International Patent Classification: Country Road, Apt. B8, Port Jefferson, New York, NY C07C 6 753 9 / (2006.01) A61K 31/216 (2006.01) 11777 (US). TONG, Simon; 71 Horace Harding Blvd, C07C 69/757 (2006.01) A61K 31/35 (2006.01) Great Neck, New York, NY 11020 (US). ELMES, Mat- C07C 205/55 (2006.01) A61K 31/167 (2006.01) thew; c/o 320 Life Sciences Building, Stony Brook, Uni - CO7C 233/25 (2006.01) A61K 31/4192 (2006.01) versity Stony Brook, New York, NY 11794-5215 (US). CO7D 309/06 (2006.01) A61P 43/00 (2006.01) YAN, Su; c/o Department of Chemistry, Suny Stony CO7D 249/06 (2006.01) A61P 29/00 (2006.01) Brook, 100 Nicolls Road, 104 Chemistry, Stony Brook, NY 11790-3400 (US). (21) International Application Number: PCT/US2017/021711 (74) Agent: GERSHIK, Gary, J.; Cooper & Dunham LLP, 30 Rockefeller Plaza, 20th Floor, New York, NY 10112 (US). (22) International Filing Date: 10 March 2017 (10.03.2017) (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind AO, of national protection available): AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (26) Publication Language: English BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (30) Priority Data: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, 62/307,262 11 March 2016 (11.03.2016) US KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (71) Applicant: THE RESEARCH FOUNDATION FOR MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, THE STATE UNIVERSITY OF NEW YORK [US/US]; NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 35 State Street, Albany, NY 12207-2826 (US). RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (72) Inventors: OJIMA, Iwao; 41 Roslyn Court, Port Jeffer- ZA, ZM, ZW. son, New York, NY 11777 (US). DEUTSCH, Dale; 21 Stony Brook Ave., Stony Brook, New York, NY 11790 (84) Designated States (unless otherwise indicated, for every (US). KACZOCHA, Martin; 16 Burnham Lane, Dix kind of regional protection available): ARIPO (BW, GH, Hills, New York 11746 (US). HU, Kongzhen; 150 North GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, [Continued on next page] Title: a-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF (54) RG (57) : The present invention provides a com- pound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting — the FABP with a compound, said compound having the R7 structure : Formula (I) Rt e .,.. .7 . 4.7. * N. (I) R 9 i 1-1 4 R12 71' ir) M ir) 11 R10 R11 IN 11 0 ei O WO 2017/156354 Al MIDEDIMOHNIIMMEOMOMEHOMINIMMEHOIMIE TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Published: DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, LT, SE, GA, — with international search 21(3)) report (Art. GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).