Patent SG-11201809989X-A (SG)
Title: Seco macrolide compounds
Inventor: FAJDETIC ANDREA
IPC: A61K31/7052
Filed: 2017-05-08
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 1 MI 11111 0 11101 HOE 010 1111 1 0 I MINH HE 1101 OE 1111011110111111 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\"1 WO 2017/194452 Al 16 November 2017 (16.11.2017) WIPO I PCT (51) International Patent Classification: Zagreb (HR). POLJAK, Visnja; Nuevolution Ronneggade C07H 17/02 (2006.01) A61K 31/7048 (2006.01) 8, 2100 Copenhagen (DK). C07H 17/08 (2006.01) A61K 31/7052 (2006.01) C07D 273/01 (2006.01) A61P 37/00 (2006.01) (74) Agent: BAR, Gregory, Louis, Joseph; Galapagos NV, Generaal De Wittelaan L11/A3, 2800 Mechelen (BE). (21) International Application Number: PCT/EP2017/060889 (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: 08 May 2017 (08.05.2017) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (26) Publication Language: English KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (30) Priority Data: 1608236.4 11 May 2016 (11.05.2016) GB MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (71) Applicant: FIDELTA D.O.O. [HR/HR]; Prilaz Baruna TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Filipovica 29, 10000 Zagreb (HR). (84) Designated States (unless otherwise indicated, for every (72) Inventors: FAJDETIC, Andrea; Istarska 62, 10000 Za- greb (HR). MATANOVIC SKUGOR, Maja; Havidice- va 10, 10000 Zagreb (HR). ELENKOV, Ivaylo; Fidelta d.o.o. Prilaz baruna, Filipovica 29, 10000 Zagreb (HR). KRAGOL, Goran; Fidelta d.o.o. Prilaz baruna, Filipovi- ca 29, 10000 Zagreb (HR). BUKVIC, Mirjana; Fidelta d.o.o. Prilaz baruna, Filipovica 29, 10000 Zagreb (HR). MARUSIC ISTUK, Zorica; Fidelta d.o.o. Prilaz baruna, Filipovica 29, 10000 Zagreb (HR). KOSTRUN, Sanja; kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). = Fidelta d.o.o. Prilaz baruna, Filipovica 29, 10000 Zagreb Declarations under Rule 4.17: (HR). ZIHER, Dinko; Fidelta d.o.o. Prilaz baruna, Fil- — as to applicant's entitlement to apply for and be granted a ipovica 29, 10000 Zagreb (HR). RUPCIC, Renata; Fidelta patent (Rule 4.17(ii)) d.o.o. Prilaz baruna, Filipovica 29, 10000 Zagreb (HR). — of inventorship (Rule 4.17(iv)) BUTKOVIC, Kristina; Fidelta d.o.o. Prilaz baruna, Fil- ipovica 29, 10000 Zagreb (HR). DUKSI, Marko; Fildelta Published: d.o.o. Prilaz baruna, Filipovica 29, 10000 Zagreb (HR). — with international search report (Art. 21(3)) OZIMEC LANDEK, Ivana; Fidelta d.o.o. Prilaz baruna, Filipovica 29, 10000 Zagreb (HR). PESIC, Dijana; Fidelta d.o.o. Prilaz baruna, Filipovica 29, 10000 Zagreb (HR). HUTINEC, Antun; Fidelta d.o.o. Prilaz baruna, Filipovi- ca 29, 10000 Zagreb (HR). MESIC, Milan; Fidelta d.o.o. Prilaz baruna, Filipovica 29, 10000 Zagreb (HR). SAXTY, Gordon; Fidelta d.o.o. Prilaz baruna, Filipovica 29, 10000 Title: SECO MACROLIDE COMPOUNDS (54) 1-1 (57) : The present invention relates to seco (opened ring) macrolide compounds of for- .4 R N Z 1 Z2 mula (I), to the process for preparation thereof, to the use of said seco macrolide compounds as based based macrocycles ei kn macrolide macrocycles, to macrolide p X' /9a 8 obtained from said seco macrolide compounds, to the process for preparation of macrolide based 1 71' macrocycles, to the pharmaceutical compositions comprising macrolide based macrocycles, and to 71' A 2 the use of macrolide based macrocycles as therapeutic agents. 01 5 Il R 1 Xi' R2a Ir . \"' © Il R 2b (I) ei B i BZ O