Patent SG-11201900113U-A (SG)
Title: Solid forms of ttk inhibitor
Inventor: LI SZE-WAN
IPC: C30B7/02
Filed: 2017-07-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 January 2018 (25.01.2018) WIPO I PCT (10) International Publication Number WO 2018/014116 A1 (51) International Patent Classification: C07D 487/04 (2006.01) A61P 35/00 (2006.01) A61K31/519 (2006.01) C30B 7/02 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/CA2017/050848 13 July 2017 (13.07.2017) English English (30) Priority Data: 62/363,424 18 July 2016 (18.07.2016) US (71) Applicant: UNIVERSITY HEALTH NETWORK [CA/CA]; 190 Elizabeth Street, R. Fraser Elliott Building - Room 1S-417, Toronto, Ontario M5G 2C4 (CA). (72) Inventors: LI, Sze-Wan; 509 Roselawn Avenue, Toronto, Ontario M5N 1K2 (CA). PAULS, Heinz W.; 460 Fourth Line, Oakville, Ontario L6L 5A4 (CA). SAMPSON, Peter Brent; 1320 Ridgebank Drive, Oakville, Ontario L6M 4A5 (CA). (74) Agent: BAKER, James D. et al.; Gowling WLG (canada) LLP, Suite 2600, 160 Elgin Street, Ottawa, Ontario KIP 1C3 (CA). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (54) Title: SOLID FORMS OF TTK INHIBITOR Figure 1. XRFD of Compound (I) Bisphosphatc Hcmihydratc Co-Crystal i-H i-H •t i-H © 00 i-H o CJ o £ (57) : The present invention relates to a novel co-crystal of the compound of formula (I): (Formula (I)) wherein the co-former molecule is bisphosphate hemihydrate, to processes for the preparation of the co-crystal, to pharmaceutical compositions containing the co-crystal, to the use of such a co-crystal in the manufacture of a medicament for use in the treatment of cancer and to methods of treating such diseases in the human or animal body by administering a therapeutically effective amount of such a co-crystal. [Continued on next page] WO 2018/014116 A1 llll II II11 III III III I III II III III II III TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(Hi)) Published: — with international search report (Art. 21(3))