Patent SG-11201901070Y-A (SG)
Title: Formulations for oral administration of active agents
Inventor: BURSHTEIN GREGORY
IPC: A61P19/10
Filed: 2017-08-17
Abstract: GSG • Pize - na \"Thti- - 1.5 mg - Pterse TH(1-34) - a5373g' 3 Sa-t.gm calcium - 1.3r • , C8;Ckifn - L 20D .33:0 Ti me (minutes) FIG. 5 1Ca W O 20 18/0339 27 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 22 February 2018 (22.02.2018) WIP0 I PCT 0111111010 0111 °nolo olimin omoi Holm° oimIE (10) International Publication Number WO 2018/033927 Al (51) International Patent Classification: A61K 38/29 (2006.01) A61P 19/08 (2006.01) A61K 9/20 (2006.01) A61K 31/195 (2006.01) A61P 19/10 (2006.01) (21) International Application Number: PCT/IL2017/050920 (22) International Filing Date: 17 August 2017 (17.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/375,989 17 August 2016 (17.08.2016) US (71) Applicant: ENTERA BIO LTD. [IL/IL]; Jerusalem Bio Park, Hadassah Ein-Kerem, P.O. Box 12117, 9112002 Jerusalem (IL). (72) Inventors: BURSHTEIN, Gregory; 71/8 Kislev Street, 7177625 Modiin (IL). ROTHNER, Ariel; 13a Gideon Street, Apt. 16, 9350614 Jerusalem (IL). SCHWARTZ, Phillip M.; 36/5 Rachel Imenu Street, 9322823 Jerusalem (IL). GALITZER, Hillel; 43 Slav Street, 7681200 Yad Binyamin (IL). (74) Agent: EHRLICH, Gal et al.; G. E. EHRLICH (1995) LTD., 11 Menachem Begin Road, 5268104 Ramat Gan (IL). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (54) Title: FORMULATIONS FOR ORAL ADMINISTRATION OF ACTIVE AGENTS (57) : Pharmaceutical compositions comprising a therapeutically active agent and an absorption enhancer such as NAC, NAD, 5-CNAC, 4-MOAC, 4-CNAB or a salt thereof, for use in the treatment of a condition treatable by said therapeutically active agent, are provided. The compositions are for concomitant oral administration of two or more of the unit dosage form, which form together a therapeutically effective amount of the therapeutically active agent and an effective amount of the absorption enhancer. Multi-dose compositions comprising the two or more of the unit dosage form are also provided. [Continued on next page] WO 2018/033927 Al MIDEDIM011111 11111111E10101011101001101010ERVOIS MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3))