baber/WOPTO huggingface dataset:
Patent EP-3697448-A1 (EP)
Title: Methods of expressing a polynucleotide of interest in the cone photoreceptors of a subject comprising the subretinal delivery of a therapeutically effective amount of a recombinant aav9-derived vector
Inventor: DALKARA DENIZ
IPC: A61K48/00
Filed: 2018-10-22
Abstract: Intraocular injection of adeno-associated viral (AAV) vectors has been an evident route for delivering gene drugs into the retina. Currently, the vectors need to be injected into the subretinal space in order to provide gene delivery to cones. In this approach, gene delivery is limited to cells that contact the local "bleb" of injected fluid. Furthermore, retinal detachment that occurs during subretinal injections is a concern in eyes with retinal degeneration. Here, the inventors establish several new vector-promoter combinations to overcome the limitations associated with AAV-mediated cone transduction in the fovea with supporting studies in mouse models, human induced pluripotent stem cell-derived organoids, post-mortem human retinal explants and living macaques. They show that an AAV9 variant provides efficient foveal cone transduction when injected into the subretinal space several millimeters away from the fovea, without detaching this delicate region. The delivery modality relies on a cone-specific promoter and result in high-level transgene expression compatible with optogenetic vision restoration. Accordingly, the present invention relates to method of expressing a polynucleotide of interest in the cone photoreceptors of a subject comprising subretinal delivery of a therapeutically effective amount of a recombinant AAV9-derived vector comprising a VP1 capsid protein as set forth in SEQ ID NO: 11 and the polynucleotide of interest under the control of the pR1.7 promoter as set forth in SEQ ID NO: 12.25
Patent EP-3707972-A1 (EP)
Inventor: OSTHOLT ROMAN
IPC: H01L21/60
Filed: 2018-10-17
Abstract: Ein Verfahren zur Integration von Halbleiter-Bauelementen (9) auf engem Raum, insbesondere zur 3D-Integration, bei dem die Halbleiter-Bauelemente (9) nach der Positionierung relativ zu einem Trägersubstrat (10) und/oder einer Umverdrahtungsschicht (Redistribution Layer RDL) (13) durch Einbringen einer Vergussmasse (12) geschützt und in ihrer relativen Position fixiert werden,zeichnet sich dadurch aus, dass vor dem Einbringen der Vergussmasse (12) ein Glassubstrat (1) mit einer Vielzahl von durch Zwischenwände (3) getrennten Ausnehmungen (2) zur Aufnahme von einem Halbleiter-Bauelement (9) derart positioniert wird, dass das Halbleiter-Bauelement (9) durch die ihm zugewandten Seitenwandflächen (8) der jeweiligen Zwischenwände (3) des Glassubstrates (1) umschlossen ist.
Patent EP-3589254-A1 (EP)
Inventor: DIMITROV DIMITRE PETKOV
IPC: A61G5/00
Filed: 2018-04-17
Abstract: An apparatus includes a frame assembly configured to be selectively connectable with a seat assembly of a wheelchair assembly once the seat assembly is selectively disconnected and removed from the wheelchair assembly. The frame assembly is also configured to be selectively connectable with spaced-apart wheel assemblies of the wheelchair assembly once the spaced-apart wheel assemblies are selectively disconnected and removed from the wheelchair assembly.
Patent EP-3619991-A1 (EP)
Inventor: CHRISTOFFERSSON JAN
IPC: H04W72/02
Filed: 2018-03-15
Abstract: A method performed by a communications device 208 for transmitting a message in response to a Random Access Response (RAR) message received from a Radio Network Node (RNN) 206. The RAR message comprises multiple grants. When the message to be transmitted requires resources provided by any one grant out of the multiple grants, the communications device selects one grant out of the multiple grants. When the message to be transmitted requires resources provided by two or more grants out of the multiple grants, the communications device selects the two or more of the grants out of the multiple grants. When the message to be transmitted requires more resources than provided by the multiple grants, the communications device selects one grant out of the multiple grants. The communications device transmits, to the RNN, the message using resources provided by the selected at least one grant out of the multiple grants.
Patent EP-3626313-A1 (EP)
Inventor: INOUE YASUFUMI
IPC: A62C31/02
Filed: 2018-05-15
Abstract: Problem: 
     To provide a injection head for liquefied fire-extinguishing agent that has good diffusing and vaporizing properties of the liquefied fire-extinguishing agent and that can increase the range subject to fire-extinguishing that can be covered with one injection head and that can raise the rate of reducing noise. 
     Means to solve the problem: 
     Injection head 1 to be installed to discharge the liquefied fire-extinguishing agent to the fire-extinguishing subject area in the fire-extinguishing equipment to use the liquefied fire-extinguishing agent, and it is equipped with injection head proper 2 to which piping to supply the liquefied fire-extinguishing agent is connected, orifice plate 3 forming orifices 31 installed to the injection head proper 2, block-shaped porous member 4 installed at the outlet of the orifices 31, and deflector 6 installed across discharging clearance D of the liquefied fire-extinguishing agent to the porous member 4.
Patent EP-3720805-A1 (EP)
Inventor: CHRISTIANSEN JONAS
IPC: B67D1/04
Filed: 2018-12-04
Abstract: A beverage dispensing system (10) for dispensing a beverage stored in a collapsible beverage container (18) comprising a base part (14), a beverage container connector for connecting to a beverage outlet of said collapsible beverage container (18), and a lid (12) connectable to said base part (14), in which said lid (12) and said base part (14) define a sealed inner space (16) for accommodating and encapsulating said collapsible beverage container (18), and in which said beverage dispensing system (10) further comprises a vacuum pump (32) in fluid communication with said inner space (16), thereby collapsing said collapsible beverage container (18) and forcing said beverage out of the collapsible beverage container (18) through a tapping line (26) and out through a tapping device (28).
Patent EP-3634481-A1 (EP)
Inventor: KAPRE SUBHASH V
IPC: A61K39/09
Filed: 2018-06-11
Abstract: The disclosure describes compositions containing conjugates using novel linkers, bivalent polysaccharide conjugates, and methods of bivalent polysaccharide conjugation in the development of multivalent conjugate vaccines. Conjugation of capsular polysaccharides to carrier proteins is carried out using homo-bifunctional and/or hetero-bifunctional linkers of specific lengths. Incorporation of the linkers and their use in bifunctional linkers induces higher titers of functional antibodies with high avidity, eliciting higher immunologic memory, and reduced carrier protein effect. This provides immunochemically cross-reactive capsular polysaccharides wherein one or more cross-reactive capsular polysaccharides are conjugated sequentially or concurrently to carrier protein using bifunctional linkers bearing the same or different functional groups. Such a linker and the size of the capsular polysaccharides provides an effective multivalent conjugate vaccine with high antibody titers and a reduced carrier effect and results in reduction in the content of the capsular polysaccharide and protein per dose of vaccine which reduces reactogenicity.
Patent EP-3468277-A1 (EP)
Title: Method and apparatus for determining transport block size
Inventor: LYU YONGXIA
IPC: H04W72/04
Filed: 2018-06-15
Abstract: Embodiments of this application disclose a method for determining a transport block size, and an apparatus. The method includes: receiving, by a terminal device, control information sent by a network device, where the control information includes indication information and resource information of a data channel; determining, by the terminal device, a modulation scheme and a code rate based on a first mapping relationship set and the indication information, and determining number of time-frequency resources based on the resource information of the data channel; determining, by the terminal device, a first transport block size TBS based on the modulation scheme, the code rate, and the number of time-frequency resources; and decoding, by the terminal device based on the TBS, the data channel carried on the time-frequency resources, or sending, by the terminal device on the time-frequency resources, the data channel based on the TBS. According to the embodiments of this application, efficiency in determining the transport block size can be improved, and therefore transmission efficiency of the data channel can be improved.
Patent EP-3643746-A1 (EP)
Inventor: YAMAUCHI KENJI
IPC: H01M10/052
Filed: 2018-06-21
Abstract: The present invention provides a resin composition which has excellent decomposability at low temperature, can provide a molded article having high strength, and enables an increase in the number of layers and thinning so as to enable production of an all-solid-state battery and a ceramic laminate (e.g., a multilayer ceramic capacitor) having excellent properties. The present invention also relates to an inorganic fine particle-dispersed slurry composition containing the resin composition, an inorganic fine particle-dispersed sheet, a method for producing an all-solid-state battery, and a method for producing a multilayer ceramic capacitor. The present invention relates to a resin composition containing a (meth)acrylic resin, the (meth)acrylic resin containing 20 to 70% by weight in total of a segment derived from methyl methacrylate and a segment derived from isobutyl methacrylate, 1 to 10% by weight of a segment derived from a glycidyl group-containing (meth)acrylate, and 5 to 40% by weight of a segment derived from a (meth)acrylate containing an ester substituent having a carbon number of 8 or more.
Patent EP-3729634-A1 (EP)
Inventor: HAMMEL WOLFGANG
IPC: H02P6/18
Filed: 2018-12-11
Abstract: The invention relates to a method for determining the rotor position of a three-phase machine without using a rotary encoder, and to a device for controlling a three-phase motor without using a rotary encoder, wherein the three-phase machine is fed by a converter that can be operated by means of pulse-width modulation, and wherein the converter has model variables for the rotor angle and the current indicator of the three-phase machine, and wherein the converter has means by using which, in control operation, at least two values are measured which represent a measure of the local inductances of the machine, wherein the error of the model rotor angle is determined in that, depending on the model rotor angle and the model current indicator, at least two weighting factors are determined, and in that a weighted sum is formed from the at least two measured values and the at least two weighting factors, and in that a further offset value is subtracted from the sum, which is likewise determined on the basis of the model rotor angle and the model current indicator.
Patent EP-3649274-A1 (EP)
Inventor: WHITMORE DAVID WILLIAM
IPC: C23F13/20
Filed: 2018-04-26
Abstract: In a method for cathodically protecting and/or passivating a metal section in an ionically conductive material such as steel reinforcement in concrete or mortar, an impressed current or sacrificial anode communicates ionic current to the metal section and a storage component of electrical energy which can be a cell, battery or capacitor is provided as a component of the anode. The storage component can have replacement energy introduced by re-charging or replacing the component from an outside supply. Typically the cell or storage capacitor has an outer case which carries an anode material as an integral outer component. A mechanical clamp is provided to attach the assembly to a rebar. A current limiter is provided which prevents excess current draining the supply.
Patent EP-3704588-A1 (EP)
Inventor: GRANADE CHRISTOPHER
IPC: G06F11/36
Filed: 2018-12-02
Abstract: The disclosed technology includes example embodiments that provide a framework for testing quantum programs in a manner similar to unit testing of classical programs by using a simulator that can predict the probability of measurements in a quantum system (known as a "strong simulator"). For a particular quantum program, embodiments of the disclosed technology use information exposed by strong simulation that would not otherwise be available to compare the given program to a desired reference program.
Patent EP-3653347-A1 (EP)
Inventor: NAKATA HIROYUKI
IPC: B25J9/10
Filed: 2018-06-21
Abstract: A robot control device includes the following: a main control unit; a servo control unit, which receives a position command θc from the main control unit; and a bending correction block (24), which corrects the bending of the reduction gear connected to the servo motor. The bending correction block (24) includes the following: a first position-correction-value calculation means (63), which finds a first position-command correction value θsgc based on the position command θc; and a second position-command-correction-value calculation means (64), which finds a second position-command correction value θskc based on the interference torque τa. The servo control unit drives the servo motor based on a new position command obtained by adding the first position-command correction value θsgc and the second position-command correction value θskc to the position command θc.
Patent EP-3727050-A1 (EP)
Inventor: MELIA PAUL
IPC: A24D3/02
Filed: 2018-12-20
Abstract: A mouthpiece or filter element comprising a longitudinally extending hollow rod of filtering material having inner and outer surfaces, the inner surface defining at least one longitudinally extending channel which extends along the full length of the mouthpiece or filter element, wherein the distance between the inner and outer surfaces is 1 mm or less, wherein the filtering material of the mouthpiece or filter element comprises a plasticiser, wherein the amount of plasticiser present in the filtering material is less than 21.5%, e.g. less than 19%, by total weight of the filtering material and plasticiser.
Patent EP-3723971-A1 (EP)
Title: Forming drum for building a tyre for vehicle wheels and method for checking the geometry of a forming drum in a process for building a tyre for vehicle wheels
Inventor: MANCINI GIANNI
IPC: B29D30/24
Filed: 2018-12-13
Abstract: A forming drum (1) for building a tyre for vehicle wheels comprises a central shaft (2), first sectors (3) radially mobile between a contracted condition in which they are brought towards the central shaft (2) and an expanded condition in which they are radially moved away from the central shaft (2), second sectors (18) radially mobile between a contracted condition in which they are brought towards the central shaft (2) and an expanded condition in which they are radially moved away from the central shaft (2), radial movement devices (11) active between the central shaft (2) and the first sectors (3) to move the first sectors (3) between the contracted condition and the expanded condition and vice-versa. Kinematic mechanisms (27) are active between the first sectors (3) and the second sectors (18) and kinematically connect them to radially move the second sectors (18) between the contracted condition and the expanded condition and vice- versa when the first sectors (3) move radially between the contracted condition and the expanded condition and vice-versa. The first sectors (3) and the second sectors (18) are circumferentially aligned when they are in the respective expanded conditions to define a substantially continuous annular surface (la), the second sectors (18) are radially inner with respect to the first sectors (3) when the first sectors (3) and the second sectors (18) are in the respective contracted conditions.
Patent EP-3720909-A1 (EP)
Title: Offshore hose outer cladding comprising at least one block copolymer
Inventor: DANG PATRICK
IPC: B32B1/08
Filed: 2018-12-07
Abstract: The invention relates to an outer cladding for an offshore hose, comprising at least one block copolymer containg at least one rigid polyamide block and at least one flexible block. The invention relates in particular to a flexible tubular pipe for conducting fluids in the field of offshore oil extraction, characterized in that said pipe comprises at least one such outer cladding. The invention also relates to the use of a block copolymer containing at least one rigid polyamide block and at least one flexible block, for manufacturing a part that is both resistant to hydrolysis and CO2-permeable, characterized in that the flexible block comprises amine chain ends.
Patent EP-3728626-A1 (EP)
Title: Methods to detect microorganisms
Inventor: WITCHER KELVIN J
IPC: C12Q1/22
Filed: 2018-12-17
Abstract: A method is provided. The method includes providing an article, the article including a nonwoven substrate having a copolymer grafted thereto, the copolymer including interpolymerized monomer units of a quaternary ammonium-containing ligand monomers; an amide monomer; an oxy monomer; and a coating on the nonwoven substrate, the coating including a plurality of test microorganisms, an enzyme or a second substrate; and contacting the article with a detection medium for a period of time.
Patent EP-3665861-A1 (EP)
Title: Hash-based data verification system
Inventor: BETTGER DAVID DUANE
IPC: H04L9/06
Filed: 2018-08-09
Abstract: An acceptance hash code is disclosed herein. An acceptance hash code is a value generated by a device using a hash function. The acceptance hash code itself may represent a legally enforceable document. The acceptance hash code may be structured in a manner such that a device operated by a user can transmit a legally enforceable document over a network using a smaller file size than is possible with conventional secure transaction techniques. In addition, the manner in which the acceptance hash code is generated allows a receiving device to verify that the document elements of the document are as expected and to verify an identity of a user that allegedly executed the document. Thus, even if a malicious user attempts to alter document elements or perform other fraudulent activity, the receiving device can use the acceptance hash code to identify such activity and prevent a transaction from being completed.
Patent EP-3664830-A1 (EP)
Inventor: WANG HUAWEI
IPC: A61K38/00
Filed: 2018-08-07
Abstract: Provided herein are cytoplasts, compositions comprising cytoplasts, methods of using cytoplasts, and methods of treating a subject, such as providing benefits to a healthy or unhealthy subject, or treating or diagnosing a disease or condition in a subject. In some embodiments, methods of treating a subject include: administering to the subject a therapeutically effective amount of a composition comprising a cytoplast. Also, provided herein are compositions (e.g., pharmaceutical compositions) that include a cytoplast. Also, provided herein are kits comprising instructions for using the compositions or methods.
Patent EP-3663454-A1 (EP)
Inventor: KIM BO-BIN
IPC: D06F39/00
Filed: 2018-08-24
Abstract: Disclosed is an electronic device. The electronic device comprises: a display and a processor, wherein, when at least one condition among the time required to treat an object and an object treatment completion time is input, the processor identifies a plurality of object treatment courses that comply with the condition, identifies the order of priority of the plurality of object treatment courses according to predetermined criteria, and controls the display to provide a list listing information about the plurality of object treatment courses on the basis of the identified order of priority, wherein the object treatment is a process in which an object is cleaned or dried by means of at least one among a cleaning operation and a drying operation.
Patent EP-3672145-A1 (EP)
Inventor: LI ZHENGYU
IPC: H04L9/08
Filed: 2018-09-11
Abstract: This application discloses a continuous-variable quantum key distribution (CV-QKD) device and method. The device includes a light source, a modulation unit, a first random number generator, and a processor, where the processor is configured to obtain a first data sequence based on a preset quantity of modulation format symbols, a distribution probability of each symbol, and a first random number sequence generated by the first random number generator, and obtain a second data sequence based on the first data sequence; and the modulation unit is configured to modulate, based on to the first data sequence, a signal emitted by the light source to output a second optical signal, where the second optical signal does not need to include quantum states with a quantity in an order of magnitude of 28 x 28 required in an existing Gaussian protocol. Therefore, implementation difficulty is low. In addition, this application further proposes an EB model equivalent to the device, thereby implementing strict provable security.
Patent EP-3686448-A1 (EP)
Title: Ball joint
Inventor: HIROTA TAKUMA
IPC: F16J3/04
Filed: 2018-08-20
Abstract: Provided is a ball joint capable of stably maintaining sealing performance over a long period even when a coupling member includes a gap. In the ball joint, a shaft portion 120 of a ball stud includes an annular concave portion 121 and an annular convex portion 122 that is disposed at a position above the annular concave portion 121 and below a coupling part between the shaft portion 120 and a knuckle 300, an inner peripheral surface side of a seal portion 430 of a dust cover is configured to be slidably in close contact with both of an outer peripheral surface of the annular concave portion 121 and an outer peripheral surface of the annular convex potion 122, an outer peripheral surface side of the seal portion 430 is provided with a clamping member 520 that clamps the seal portion 430 to the shaft portion 120, and a top surface 444 of the seal portion 430 facing the knuckle 300 is constituted by an inclined surface generated by the seal portion tapering down in diameter toward the knuckle 300.
Patent EP-3685981-A1 (EP)
Inventor: YASUE AKIRA
IPC: B29K101/12
Filed: 2018-09-21
Abstract: The present invention addresses the problem of providing a molding method capable of molding a molded article having excellent strength and reducing manufacturing costs by shortening a molding cycle when obtaining a molded article from a fiber-reinforced thermoplastic resin by compression molding. The present invention relates to a molding method which obtains a fiber-reinforced thermoplastic resin by kneading a thermoplastic resin and a reinforcing fiber (14), and a molded article from the fiber-reinforced thermoplastic resin by compression molding. The molding method of the molded article comprising the fiber-reinforced thermoplastic resin according to the present invention comprises: a molding step for obtaining a first molded article from a predetermined amount of a fiber-reinforced thermoplastic resin through a molding die (4); a carrying-in step for opening the molding die (4), taking out the first molded article, and inserting the first molded article into a cooling die (5); and a compression cooling step for cooling the first molded article by compressing the first molded article through the cooling die (5).
Patent EP-3729868-A1 (EP)
Title: Network slice selection assistance information configuration
Inventor: VELEV GENADI
IPC: H04W48/00
Filed: 2018-12-20
Abstract: Apparatuses, methods, and systems are disclosed for NSSAI configuration. One method (1100) includes determining (1102), within a unified data management function, a default network slice selection assistance information for a public land mobile network for a remote unit. The method (1100) includes providing (1104) the default network slice selection assistance information to the remote unit.