Patent SG-11202000136Y-A (SG)
Title: Preparation comprising vonoprazan
Inventor: FUJII HIROYUKI
IPC: A61K31/4439
Filed: 2018-07-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) oviolo VIII VIII VIII 010 Hu Hs (19) World Intellectual Property Organization International Bureau (10) International Publication Number WO 2019/013310 Al (43) International Publication Date 17 January 2019 (17.01.2019) WIPO I PCT (51) International Patent Classification: A61K 9/00 (2006.01) A61K 9/50 (2006.01) A61K 9/20 (2006.01) A61K 31/4439 (2006.01) (21) International Application Number: PCT/JP2018/026416 Published: — with international search report (Art 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (22) International Filing Date: 09 July 2018 (09.07.2018) English English (25) Filing Language: (26) Publication Language: (30) Priority Data: 2017-135046 10 July 2017 (10.07.2017) JP (71) Applicant: TAKEDA PHARMACEUTICAL COMPA- NY LIMITED [JP/JP]; 1-1, Doshomachi 4-chome, Chuo- ku, Osaka-shi, Osaka, 5410045 (JP). (72) Inventors: FUJII, Hiroyuki; c/o TAKEDA PHARMA- CEUTICAL COMPANY LIMITED, 17-85, Jusohonmachi 2-chome, Yodogawa-ku, Osaka-shi, Osaka, 5320024 (JP). SUZUKI, Akira; c/o TAKEDA CONSUMER HEALTH- CARE COMPANY LIMITED, 17-85, Jusohonmachi 2- chome, Yodogawa-ku, Osaka-shi, Osaka, 5320024 (JP). (74) Agent: TAKASHIMA, Hajime et al.; Meiji Yasuda Seimei Osaka Midosuji Bldg., 1-1, Fushimimachi 4-chome, Chuo-ku, Osaka-shi, Osaka, 5410044 (JP). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: PREPARATION COMPRISING VONOPRAZAN (57) : The present invention aims to provide a preparation expected, to improve the bitter taste of an organic acid salt of vonoprazan and permit rapid dissolution of the organic acid salt of vonoprazan after administration. The present invention provides a preparation containing fine granules or granules containing (1) a core granule containing an organic acid salt of vonoprazan, (2) an intermediate layer containing the same organic acid as the organic acid forming the salt of vonoprazan in (1), or a salt thereof, and (3) a coating layer containing a water-insoluble polymer.