baber/WOPTO huggingface dataset:
Patent CA-3160316-A1 (CA)
Title: Peptides and methods of treating sepsis, atherosclerosis, thrombosis, stroke, heart attack and inflammation
Inventor: DU XIAOPING
IPC: C07K14/47
Filed: 2020-11-09
Abstract: The present disclosure provides peptides that inhibit a binding interaction between a ß integrin and a G protein subunit, as well as compositions, e.g., pharmaceutical compositions, particularly nanoparticle compositions, comprising the same and to methods of using the peptides to treat atherosclerosis, thrombosis, stroke, heart attack, inflammation, acute respiratory distress syndrome (ARDS), autoimmune diseases, AV Fistula for hemodialysis or organ transplantation.
Patent CA-3164080-A1 (CA)
Inventor: SABEDDU GIAN MATTEO
IPC: F16K5/06
Filed: 2020-10-21
Abstract: L'invention concerne un joint (1) pour un clapet à bille destiné à raccorder des tuyaux dans des circuits de fluide sous pression ou basse pression, ledit clapet à bille comprenant : - un corps de clapet (3) ; - une bille logée dans le corps de clapet de sorte à pouvoir tourner à l'intérieur ; - un premier et un deuxième siège (5) disposés à l'intérieur dudit corps et conçus pour contenir ladite bille ; - des moyens d'étanchéité du type comprenant un premier et un deuxième joint interposés entre lesdits premier et deuxième sièges et ladite bille ; chaque joint étant un joint composite monobloc et comprenant au moins une première couche (10) et une deuxième couche (20) en matériaux thermoplastiques, la dureté, la résistance à la traction et le coefficient de valeurs de frottement étant différents entre lesdites première et deuxième couches, et ladite première couche présentant des valeurs inférieures et coopérant directement avec ladite bille, d'une façon étanche aux fluides, tandis que ladite deuxième couche présente des valeurs supérieures, sert normalement de support à ladite première couche et coopère avec ladite bille, d'une façon étanche aux fluides, uniquement lorsque des conditions de fonctionnement déterminées sont remplies.
Patent CA-3165000-A1 (CA)
Title: Combination treatment of liver diseases using integrin inhibitors
Inventor: ANDERSON KRAIG
IPC: A61P1/16
Filed: 2020-12-18
Abstract: The invention provides a pharmaceutical combination including an a?ß1 integrin inhibitor and at least one additional therapeutic agent for preventing, delaying or treating liver diseases or disorders. The at least one additional therapeutic agent may be a farnesoid X receptor (FXR) agonist. For example, the pharmaceutical combination includes (S)-2-(4-methyltetrahydro-2H-pyran-4-carboxamido)-9-(5,6,7,8-tetrahydro-l,8-naphthyridin-2-yl)nonanoic acid (Compound 1) and 2-[3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-l,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid (tropifexor).
Patent CA-3168055-A1 (CA)
Inventor: SIMONS EMMANUEL JOHN
IPC: A61K48/00
Filed: 2021-02-19
Abstract: Provided herein are compositions that include at least two different nucleic acid vectors, where each of the at least two different vectors includes a coding sequence that encodes a different portion of an otoferlin protein, and the use of these compositions to treat hearing loss in a subject.
Patent CA-3168237-A1 (CA)
Title: Back-drag bucket accessory
Inventor: BOURGAULT GERARD F
IPC: E02F3/815
Filed: 2022-07-19
Abstract: A bucket for a loader includes a main body and a pair of swing plates pivotably coupled to the main body for defining an exterior collection space for gathering material from the ground surface when operating the bucket in a back-dragging mode.  Each swing plate is pivotable relative to the main body between a first position and a second position.  When in the first position, the swing plate lower edge is raised above an outer surface of the bottom wall. When in the second position, the swing plate protrudes past the outer surface of the bottom wall, with inwardly directed faces of the swing plates cooperating with an outer surface of a bottom wall of the main body to partially enclose an exterior collection space when back-dragging.
Patent CA-3168560-A1 (CA)
Title: Composes anti-senescence ameliores et leurs utilisations
Inventor: DE KEIZER PETERUS LEONARDUS JOSEPHUS
IPC: A61K38/00
Filed: 2021-02-22
Abstract: La présente invention concerne des composés améliorés destinés à être utilisés dans le traitement de maladies ou d'états où l'élimination de cellules sénescentes, de cellules meurtries et/ou de cellules cancéreuses est bénéfique, par exemple le cancer. L'invention concerne également des procédés de traitement d'un individu atteint ou suspecté d'être atteint d'une maladie ou d'un état dans lequel l'élimination de cellules sénescentes, de cellules meurtries et/ou de cellules cancéreuses est bénéfique.
Patent CA-3170689-A1 (CA)
Title: Mobile gas and chemical imaging camera
Inventor: KESTER ROBERT TIMOTHY
IPC: G01N21/84
Filed: 2015-04-30
Abstract: In one embodiment, an infrared (IR) imaging system for determining a concentration of a target species in an object is disclosed. The imaging system can include an optical system including an optical focal plane array (FPA) unit.  The optical system can have components defining at least two optical channels thereof, said at least two optical channels being spatially and spectrally different from one another. Each of the at least two optical channels can be positioned to transfer IR radiation incident on the optical system towards the optical FPA. The system can include a processing unit containing a processor that can be configured to acquire multispectral optical data representing said target species from the IR radiation received at the optical FPA. Said optical system and said processing unit can be contained together in a data acquisition and processing module configured to be worn or carried by a person.
Patent CA-3174350-A1 (CA)
Title: Compositions and methods for treating inflammatory bowel disease using ccr9 inhibitor and anti-il-23 blocking antibodies
Inventor: CAMPBELL JAMES
IPC: C07D237/00
Filed: 2021-03-31
Abstract: Provided herein are compositions, methods and kits for treating inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis in a mammal in need thereof. The method include administering to a subject with IBD a combination therapy containing a therapeutically effective amount of a chemokine receptor 9 (CCR9) inhibitor compound and a therapeutically effective amount of an anti-IL-23 antibody. Also provided herein is a kit containing the CCR9 inhibitor compound and anti-IL-23 antibody.
Patent CA-3174861-A1 (CA)
Inventor: DELLA VALLE FRANCESCO
IPC: A61P25/00
Filed: 2022-09-15
Abstract: The present invention relates to the use of N-palmitoylethanolamide (PEA) in combination with docosahexaenoic acid (DHA) in the treatment of autism spectrum disorder and other depressive syndromes. In particular, the present invention relates to the use of N-palmitoylethanolamide (PEA) in combination with docosahexaenoic acid (DHA) in the treatment of diseases characterized by decreased endogenous levels of allopregnanolone.
Patent CA-3175707-A1 (CA)
Title: Antibody tests for identifying ro negative sjogren's syndrome and use as biomarkers for dysregulated b cell responses, b cell lymphoma, tissue fibrosis salivary gland dysfunction
Inventor: FARRIS A DARISE
IPC: G01N33/564
Filed: 2021-02-04
Abstract: The present invention includes a method and kit of determining that a patient negative for anti- Ro autoantibodies has Sjögren's syndrome (SS) without performing a lip biopsy comprising: obtaining a liquid biological sample from the patient suspected of having SS; determining that the patient is negative for anti-Ro autoantibodies; and detecting autoantibodies to 1, 2, 3, 4, 5, 6, 7, 8, or 9 proteins selected from: CCDC155, DDB1, MUM1L1, NFU1, RPS29, SOX5, TCP10, ZNF655, or RPAP3, which indicate(s) that the patient has SS. Also, a lack of certain autoantibodies such as KCNAB1, KCNAB2, or as listed in Table 1, Table 2, or Table 3, and Figures 11 or 16 in Ro neg cases may be used to detect SS.
Patent CA-3176882-A1 (CA)
Inventor: SHOHAM RON
Filed: 2021-04-30
Abstract: L'invention concerne un système et un procédé permettant d'inférer des modèles de dispositifs. Le procédé consiste à déterminer des statistiques de bloc pour chaque bloc d'une pluralité de blocs d'une pluralité d'adresses de commande d'accès au support (MAC), la pluralité de blocs comprenant une pluralité de préfixes respectifs, la pluralité de blocs étant groupés en fonction de similitudes entre la pluralité de préfixes respectifs ; à générer un modèle statistique agrégé pour la pluralité de blocs en fonction de la pluralité d'adresses MAC et des statistiques de bloc, chaque bloc étant une chaîne de chiffres compris dans une de la pluralité d'adresses MAC ; et à appliquer le modèle statistique agrégé aux statistiques de bloc d'au moins un bloc de la pluralité de blocs afin de déterminer au moins un modèle de dispositif inféré, chacun desdits au moins un bloc étant groupé dans le même groupe.
Patent CA-3178458-A1 (CA)
Title: Mobile classifying or screening device
Inventor: PEYFUSS BURGHARD
IPC: B07B1/00
Filed: 2021-03-25
Abstract: The invention relates to a mobile classifying or screening device, comprising a frame for a classifying apparatus (1), which frame is arranged on a chassis. The classifying apparatus has at least one screening surface (S) for separating a fed screening material (SG) into at least two screened fractions. The frame comprises: - two lateral frame parts (12.1, 12.2), each of which is formed of longitudinal bars (14) running in the longitudinal direction, which are connected by webs (15) running transversely to the longitudinal bars (14) and which include a topmost longitudinal bar (14a) and a bottommost longitudinal bar (14b); and - at least two transverse bars (16, 17, 18, 19) running in the the transverse direction, which interconnect the two lateral frame parts (12.1, 12.2) in the region of the respective bottommost longitudinal bars (14b) of the two lateral frame parts. The classifying apparatus (1) is mounted on longitudinal bars (14) and is adjacent to a storing and metering unit (2), which is in the form of a trough-shaped feed channel having a substantially horizontal direction of discharge (AR) onto the screening surface (S).
Patent CA-3178845-A1 (CA)
Title: Gene therapy for bardet-biedl syndrome
Inventor: BEALES PHILIP
IPC: C12N15/86
Filed: 2021-04-19
Abstract: There is provided a vector for treating retinal degeneration associated with Bardet-Biedl Syndrome (BBS), wherein the vector comprises a promoter operably linked to a BBS1 gene, wherein the promoter is selected from a rhodopsin kinase (RK) promoter, a cytomegalovirus immediate-early (CMV) promoter and a CAG promoter, and wherein the vector is selected from an AAV2/8 vector, an AAV2/7m8 vector and an AAV9 vector. Also disclosed is a pharmaceutical composition comprising the vector, and use of the vector in a method of treating retinal degeneration associated with BBS comprising administering a therapeutically effective amount of the vector to a patient suffering from BBS, wherein the vector is administered directly to the eye of the patient.
Patent CA-3179361-A1 (CA)
Inventor: LEMIRE SEBASTIEN
IPC: A61K35/768
Filed: 2021-04-27
Abstract: The present disclosure relates to bacteriophage and compositions capable of infecting and killing Pseudomonas, and use of the same for treating Pseudomonas, e.g. Pseudomonas aeruginosa, bacterial infections.
Patent CA-3181821-A1 (CA)
Inventor: DEUTSCH OMER
IPC: B01L3/00
Filed: 2021-06-10
Abstract: An apparatus includes an elongate barrel (162), shaped to define a channel (164) therethrough, in which a porous carrier (170), that holds a surfactant (172), is disposed. A sponge (130) is coupled to the distal portion (124) of a plunger (122) that is dimensioned to slide snugly within the channel. While the sponge holds saliva, sliding of the plunger through the channel compresses the sponge within the channel. Compression of the sponge within the channel drives at least a portion of the saliva: (i) out of the sponge and through the carrier, and (ii) from the carrier, together with at least a portion of the surfactant, into a collection tube (180) that is reversibly couplable to an outlet (168) at a distal region of the channel. Other embodiments are also described.
Patent CA-3182774-A1 (CA)
Title: Top fired outdoor gas heat exchanger
Inventor: CABRERA ROBERT EDWARD
IPC: F24H3/00
Filed: 2022-11-22
Abstract: A furnace for a heating, ventilation, and air conditioning (HVAC) unit includes a heat exchange tube configured to flow combustion products therethrough and place the combustion products in a heat exchange relationship with an air flow directed across the heat exchange tube. The furnace also includes a burner assembly fluidly coupled to a first port of the heat exchange tube and configured to generate the combustion products directed into the heat exchange tube via the first port, and a draft inducer blower fluidly coupled to a second port of the heat exchange tube and configured to draw the combustion products through the heat exchange tube. The burner assembly is higher in position than the draft inducer blower relative to a base of the HVAC unit.
Patent CA-3189703-A1 (CA)
Inventor: LEBOLD TERRY PATRICK
IPC: C07D471/04
Filed: 2021-09-16
Abstract: L'invention concerne un composé de formule (I) ou de formule (II), des compositions pharmaceutiques le contenant, des méthodes de préparation associées et des méthodes d'utilisation associées, notamment des méthodes de traitement d'états pathologiques, de troubles et d'affections associés à la modulation de la caséine kinase 1 delta (CSNK1D), tels que ceux associés aux troubles de l'humeur/psychiatriques, les maladies neurodégénératives, les cancers, l'accoutumance et les troubles liés à l'abus de substances, la douleur, et les maladies métaboliques, formules dans lesquelles R1, R2, R3, R4, R1a, R2a, R3 et R4a sont tels que définis dans la description.
Patent CA-3192198-A1 (CA)
Title: Electrolyzer power conversion
Inventor: PMSVVSV PRASAD
IPC: H02J1/10
Filed: 2023-03-06
Abstract: A power control device for an electrolyzer that is configured to receive electrical current from a plurality of electrical power sources, rectify alternating current from a first subset of the plurality of electrical power sources, convert direct current from a second subset of the plurality of electrical power sources, provide power from the first subset and the second subset of electrical power sources to an energy bus, and receive, at the electrolyzer, power from the energy bus.
Patent CA-3192909-A1 (CA)
Inventor: BLIZZARD CHARLES D
IPC: A61P27/02
Filed: 2021-10-26
Abstract: The invention relates to a sustained release biodegradable ocular implant containing a tyrosine kinase inhibitor dispersed in a hydrogel for the treatment of a retinal disease for an extended period of time.
Patent CA-3195505-A1 (CA)
Inventor: DELAIRE MELANIE
IPC: C02F1/28
Filed: 2021-09-16
Abstract: The invention relates to a method for treating fluid, notably liquid, in particular water, containing pollutants, by passing a downward flow of fluid through a bed of activated carbon in the form of grains in a treatment station, said method comprising a partial renewal of activated carbon including at least one injection of activated carbon and at least one extraction of activated carbon. The invention also relates to a plant suitable for the implementation of the fluid treatment method of the invention.
Patent CA-3195926-A1 (CA)
Title: Material combinations and processing methods for a surgical instrument
Inventor: KRASTS ANDREW
IPC: A61B17/072
Filed: 2021-10-29
Abstract: Surface preparation for sliding surfaces can enhance wear performance for surgical instruments such as surgical staplers which include reusable mechanisms that are used multiple times with single use reload cartridges. To reduce the potential for galling wear in a metal-to-metal sliding engagement, a combination of surface hardening, surface finish, and surface coatings can be applied to metallic components of a surgical instrument. Surface hardening techniques can allow further manufacturing operations such as welding without compromising the strength of the underlying metal substrate. With stainless steel metal substrates, as surface or case hardening techniques can reduce corrosion resistance, a surface coating can be applied to inhibit surface oxidation as well as provide a barrier to metal-to-metal contact. A further lubricious coating layer such as a bone wax coating layer can enhance galling resistance.
Patent CA-3200869-A1 (CA)
Inventor: KREPS EDWIN
IPC: B41F11/02
Filed: 2021-08-18
Abstract: The invention relates to a device for aligning magnetic or magnetisable particles (P) which are contained in a coating agent (06) applied to a side of a strip-shaped or arcuate substrate (02), the device having a first aligning means (33; 33') which is arranged in the transport path of the substrate (02) to be conveyed and has a plurality of magnets (44) in the region of its side facing the transport path in order to align, in each case in a surface region having the coating agent (06), at least some of the particles (P) contained in the coating agent (06) in a defined manner in order to generate image information, wherein the magnets (44) of the first aligning means (33;33') which are used for the alignment and the substrate (02) which is supplied with the coating agent (06) containing the particles (P) move synchronously with one another at least on a portion of the transport path. At least one further aligning means (42; 43) which is attached to the frame on the transport path during operation and has a plurality of magnets (46; 47) which remain stationary in the device during operation is allocated in front of or opposite the first aligning means (33; 33') in the transport path of the substrate (02) to be conveyed. The invention further relates to a printing machine having such a device as well as to a method for aligning magnetic or magnetisable particles.
Patent CA-3201845-A1 (CA)
Inventor: HOSSBACH MARKUS
IPC: C12N15/113
Filed: 2015-11-16
Abstract: The present invention relates to antisense-oligonucleotides having a length of at least nucleotides, wherein at least two of the nucleotides are LNAs, their use as inhibitors of TGF-R signaling, pharmaceutical compositions containing such antisense-oligonucleotides and the use for prophylaxis and treatment of neurological, neurodegenerative, fibrotic and hyperproliferative diseases.
Patent CA-3202968-A1 (CA)
Inventor: HIRAYAMA JUNTA
IPC: B25J13/08
Filed: 2021-12-10
Abstract: Ce dispositif de vérification d'outil pour bras de robot comprend : une unité de traitement des images configurée pour réaliser, sur une image capturée d'un outil fixé au bras de robot, un traitement des images associé à une condition d'outil concernant le type d'outil, ou l'état d'outil, qui doit être satisfait par l'outil, et générer une image traitée résultant de l'extraction d'une zone pertinente associée à l'état d'outil ; et une unité de détermination configurée pour déterminer, sur la base de l'image traitée, si l'outil fixé au bras de robot satisfait ou non la condition d'outil.
Patent CA-3203672-A1 (CA)
Inventor: CHEN LIPING
IPC: H04B7/185
Filed: 2021-12-22
Abstract: La présente invention concerne divers agencements pour réaliser une transmodulation d'une liaison de connexion directe. Un premier flux de données et un second flux de données peuvent être modulés en une liaison de connexion directe à modulation d'ordre supérieur ayant un schéma de modulation numérique d'ordre supérieur. Un satellite peut recevoir la liaison de connexion directe de modulation d'ordre supérieur. Le satellite peut démoduler la liaison de connexion directe du modulateur d'ordre supérieur en un train de bits. Ce train de bits peut ensuite être remodulé et retransmis en tant que multiples liaisons d'utilisateur directes.
Patent CA-3205688-A1 (CA)
Inventor: HETT CHRISTOPHER
IPC: H04W12/08
Filed: 2022-01-25
Abstract: Un n?ud déployé peut commuter automatiquement d'une configuration à une autre. Le n?ud comprend une première image de micrologiciel qui correspond à une première configuration et une seconde image de micrologiciel qui correspond à une seconde configuration. Le n?ud exécute la première image de micrologiciel pour exécuter la première configuration. À un moment donné, le n?ud détermine qu'une commutation vers la seconde configuration est appropriée et commute vers la seconde configuration par activation de la seconde image de micrologiciel. La commutation ne nécessite pas d'intervention par un système central ou d'intervention manuelle. Dans certains cas, les configurations sont associées à différents protocoles de communication.
Patent CA-3207982-A1 (CA)
Inventor: NENOV DEJAN
Filed: 2019-01-25
Abstract: The present disclosure describes systems and methods for use of a distributed ledger system to securely store data, or verify data, including updates to applications, firmware, operating system libraries or other such data. Encrypted data files of one or more computing devices may be distributed to processing nodes of the distributed ledger system. The data may be subsequently retrieved and decrypted by the computing device or another device. Because the distributed ledger system creates a chain of hashes of prior blocks, the data may be immune to modification or corruption, as any changes to blocks storing the encrypted data may be immediately apparent.  A distributed ledger system may also provide a secure anti-tamper mechanism for software and fimiware updates that may be independently accessed and verified by any device.
Patent CA-3213828-A1 (CA)
Inventor: MAIER KAITLIN E
IPC: A61F6/00
Filed: 2022-03-09
Abstract: Applicateur (300) pour insérer un pessaire (304), cet applicateur comprenant un cylindre (302) et un piston (306). Le cylindre (302) présente une ouverture supérieure en forme de calice ayant un premier diamètre au niveau du bord le plus haut et un second diamètre à un emplacement intermédiaire situé plus bas que le bord le plus haut. Le premier diamètre est supérieur au second diamètre. Le piston (306) est conçu pour recevoir au moins partiellement un pessaire (304) et est logé de manière télescopique dans le cylindre (302). Le piston (306) est conçu et agencé pour éjecter le pessaire (304) du cylindre (302) lors du mouvement télescopique du piston (306) à l'intérieur du cylindre (302) vers le bord le plus haut.
Patent CA-3214277-A1 (CA)
Title: Compositions a base de transposons ltr et procedes
Inventor: CITORIK ROBERT JAMES
IPC: C12N15/10
Filed: 2022-03-18
Abstract: L'invention concerne des procédés et des compositions pour modifier un génome à un ou plusieurs emplacements dans une cellule hôte, un tissu ou un sujet.
Patent CA-3214443-A1 (CA)
Title: Procede de fabrication de noyau stratifie lie et dispositif de fabrication de noyau stratifie lie
Inventor: TAKEDA KAZUTOSHI
Filed: 2022-04-13
Abstract: L'invention concerne un procédé de fabrication d'un noyau stratifié lié dans lequel une pluralité de parties de tôle d'acier sont obtenues par pressage d'une bande de tôle d'acier, sur la ou les surfaces de laquelle une huile de travail de pressage est appliquée, et par application d'un adhésif sur une surface de la bande de tôle d'acier, puis les parties de feuille d'acier sont stratifiées et liées pour produire un noyau stratifié lié, un accélérateur de durcissement ayant une viscosité moyenne de 0,01 à 1,00 Pa·s étant appliqué sur la ou les surfaces de la bande de tôle d'acier avant l'application de l'huile de travail de pressage.