Patent AU-2013203396-B2 (AU)
Title: Anti-EMP2 therapy reduces cancer stem cells
Inventor: WADEHRA MADHURI
IPC: A61K39/00
Filed: 2013-03-14
Granted: 2016-01-14
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/148263 Al 3 October 2013 (03.10.2013) W I PO I P CT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07K16/00 (2006.01) A61K 39/395 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/US2013/03 1542 DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, 14 March 2013 (14.03.2013) KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (25) Filing Language: English NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, (26) Publication Language: English RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, (30) Priority Data: ZM, ZW. 61/617,996 30 March 2012 (30.03.2012) US (84) Designated States (unless otherwise indicated, for every (71) Applicants: THE REGENTS OF THE UNIVERSITY kind of regional protection available): ARIPO (BW, GH, OF CALIFORNIA [US/US]; 1111 Franklin Street, Oak- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, land, CA 94607-5200 (US). UNITED STATES GOV- UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, ERNMENT DEPARTMENT OF VETERANS AF- TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, FAIRS [US/US]; Office of the General Counsel, Washing- EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, ton, District of Columbia 20420 (US). PAGANINI BIO- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, PHARMA, INC. [US/US]; 17328 Ventura Blvd., #147, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Encino, California 91316-3904 (US). ML, MR, NE, SN, TD, TG). (72) Inventors: WADEHRA, Madhuri; 1604 N. Poinsettia Declarations under Rule 4.17: Avenue, Manhattan Beach, CA 90266 (US). BRAUN, Avnuetan394Hltn Bead WayhTarzana, CA 902N as to applicant's entitlement to applyfor and be granted a Jonathan; 3924 Hilton Head Way, Tarzana, CA 91356 patent (Rule 4.17(ii)) (US). GORDON, Lynn, K.; 3924 Hilton Head Way, Tarz ana, CA 91356 (US). LAZAR, Gary, S.; 5342 Aldea Av- as to the applicant's entitlement to claim the priority of the enue, Encino, CA 91316 (US). earlier application (Rule 4.17(iii)) (74) Agents: PARENT, Annette S. et al.; Morgan, Lewis & Published: Bockius LLP, One Market, Spear Street Tower, San Fran- with international search report (Art. 21(3)) cisco, CA 94105 (US). (54) Title: ANTI-EMP2 THERAPY REDUCES CANCER STEM CELLS (57) Abstract: Reduction of EMP2 expression and/or anti-EMP2 therapy reduces cancer stem cells in multiple types of cancer. For example, breast cancers stem cells were defined by the presence of HIF- 1 a, CD44 and ALDH. It is found that anti-EMP2 IgG1 can be used to reduce the numbers of cancer stem cells.