baber/WOPTO huggingface dataset:
Patent WO-2019119054-A1 (WO)
Inventor: BLUNSDEN CHRISTOPHER KINGSLEY
IPC: C01B13/02
Filed: 2018-12-21
Abstract: L'invention concerne un appareil qui fournit des opérations de détection de gaz, telles que pour la détection de concentration d'oxygène avec un concentrateur d'oxygène. Dans certaines versions, un appareil de détection de concentration de gaz ayant des capteurs de pression, de température et/ou de débit massique mesure des caractéristiques d'un mélange gazeux dans un récipient. Un dispositif de commande de l'appareil peut estimer la concentration d'un gaz constitutif dans le mélange gazeux en fonction de la pression, de la température et du débit massique mesurés. Dans certaines versions, l'appareil de détection peut mesurer une conductivité thermique de gaz enrichi et, avec un dispositif de commande, estimer la concentration d'argon dans le gaz enrichi à partir de la conductivité thermique. Le dispositif de commande peut estimer la concentration d'oxygène dans le gaz enrichi à partir de la concentration d'argon. Dans certaines versions, un concentrateur d'oxygène peut avoir un capteur de débit massique et un dispositif de commande configuré pour déclencher l'administration de bolus et/ou mesurer la concentration d'oxygène, et/ou réguler le profil de bolus sur la base de signaux provenant du capteur de débit massique.
Patent AU-2018200361-A1 (AU)
Title: Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo
Inventor: BROWN DENNIS
IPC: A61K31/497
Filed: 2018-01-16
Abstract: COMPOSITIONS AND METHODS TO IMPROVE THE THERAPEUTIC BENEFIT OF INDIRUBIN AND ANALOGS THEREOF, INCLUDING MEISOINDIGO The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutically active agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to therapeutically active agents selected from the group consisting of: (i) indirubin; (ii) an analog of indirubin; (iii) a derivative of indirubin or of an analog of indirubin; and (iv) a pharmaceutical composition comprising indirubin, an analog of indirubin, or a derivative of indirubin or of an analog of indirubin, especially meisoindigo.
Patent AU-2018201513-A1 (AU)
Title: Solution comprising nicotine in unprotonated form and protonated form
Inventor: MCADAM KEVIN GERARD
IPC: A24F40/40
Filed: 2018-03-02
Abstract: Abstract There is provided a nicotine solution comprising (i) a carrier; (ii) nicotine in unprotonated form and in protonated form; and (iii) benzoic acid.
Patent AU-2018202330-A1 (AU)
Title: Vista regulatory T cell mediator protein, vista binding agents and use thereof
Inventor: NOELLE RANDOLPH J
IPC: A61K39/00
Filed: 2018-04-03
Abstract: The present invention relates to a novel regulatory T cell protein. The protein, designated PD-L3 or VISTA resembles members of the PD-Li family, identified a novel and structurally distinct, Ig-superfamily inhibitory ligand, whose extracellular domain bears homology to the B7 family ligand PD-Li. This molecule is designated as PD-L3 or VISTA or V-domain Immunoglobulin Suppressor of T cell Activation (VISTA). Expression of VISTA is primarily within the hematopoietic compartment and is highly regulated on myeloid APCs and T cells. Therapeutic intervention of the VISTA inhibitory pathway represents a novel approach to a modulate T cell-mediated immunity for the treatment of a wide variety of cancers, e.g., ovarian, bladder cancer and melanomas. Also, VISTA proteins, especially multimeric VISTA proteins and antibodies may be used to suppress T cell immunity in autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis and arthritic conditions such as RA.
Patent AU-2018203213-A1 (AU)
Title: Endoscopic surgical clip applier including counter assembly
Inventor: BARIL JACOB C
IPC: A61B17/128
Filed: 2018-05-08
Abstract: ENDOSCOPIC SURGICAL CLIP APPLIER INCLUDING COUNTER A surgical clip applier (10), comprising: a handle assembly (12); an elongated tubular member (14) extending distally from the handle assembly (12); a rack bar (26) translatably supported in the handle assembly (12); a counter assembly (200) supported in the handle assembly (12), the counter assembly (200) including: a housing (202) including a first housing half (202a) and a second housing half (202b); a stationary post (208) positioned within the first housing half (202a) and including a plurality of locking teeth (210); a counting wheel (222) positioned to rotate within the housing (202), the counting wheel (222) including indicia (224) visible through the handle assembly (12); an actuation wheel (228 including a plurality of actuation features (232) and a plurality of inner fingers (234) configured to selectively engage with the plurality of locking teeth (210) of the stationary post (208), wherein the engagement of the plurality of inner fingers (234) of the actuation wheel (228) and the plurality of locking teeth (210) of the stationary post (208) prohibit multidirectional rotation of the counting wheel (222); and an actuator (217) supported on the rack bar (26) for translation therewith, the actuator (217) including a protrusion (218) projecting therefrom, the actuator (217) positioned to translate between a proximal position and a distal position, wherein transitioning between the proximal position and the distal position, the protrusion (218) of the actuator (217) engages the plurality of actuation features (232) to rotate the counting wheel (222) to adjust the indicia (224) of the counting wheel (222). C'4N
Patent AU-2018204255-A1 (AU)
Title: Immunogenic composition against Campylobacter jejuni
Inventor: GUERRY PATRICIA
IPC: A61K39/00
Filed: 2018-06-14
Abstract: IMMUNOGENIC COMPOSITION AGAINST CAMPYLOBACTER The inventive subject matter relates to methods of inducing an immune response in a mammal against a Campylobacterjejuni strain comprising administering to such a mammal an immunogenic composition against Campylobacterjejuni comprising isolated capsule polysaccharide from selected pathogenic Campylobacterjejuni strains. The inventive subject matter also relates to uses of such polysaccharide compositions for the manufacture of medicaments for inducing an anti-C. jejuni immune response.
Patent AU-2018214017-A1 (AU)
Title: Quantum Spin Magnetometer
Inventor: WOOD ALEXANDER
IPC: G01R33/20
Filed: 2018-08-07
Abstract: This disclosure relates to a magnetometer for measuring a magnetic field. The magnetometer comprises a solid state quantum system with at least two quantum spin states. A control signal generator sets the quantum system into a quantum state that accumulates a phase over time depending on the magnetic field. A detector measures a signal from the quantum system indicative of the accumulated phase at a measurement time after the setting of the quantum state. A processor determines a magnetic field measurement based on the signal measured by the detector. Importantly, the quantum system is mounted on a rotator that is configured to rotate the quantum system about a rotation axis that defines an angle with the direction of the magnetic field and at a rotation rate that modulates the magnetic field over the measurement time. phase sync signal U) co CO N dN I- N oC E =L Fr o r-4 Coo > C CC%4
Patent AU-2018214117-A1 (AU)
Title: A meter device
Inventor: DONAGHEY ANDREW PAUL
IPC: G06F13/00
Filed: 2018-08-10
Abstract: C: \Interwovn\NRPortbl\DCC\DXL\17502201- .doc-l0 08/2018 A meter device, including a wireless communications receiver for receiving files for said meter device; a microcontroller system for processing and storing said files, and performing a meter application defined by said files and communicating with another device using one communications protocol to transmit configuration data enabling said another device installed at a dwelling to communicate using another communications protocol. 115 111 112 150 113 101 Figure 2 2001 2002 2003 Figure 2 2010 2011 2012 Figure 3
Patent AU-2018233045-A1 (AU)
Title: Enhanced platen for pharmaceutical compounding
Inventor: SANDMANN CHRISTIAN
IPC: G01G21/28
Filed: 2018-09-21
Abstract: OF THE INVENTION A system for preparing and administering a prescribed fluidic pharmaceutical compound, such as a chemotherapy compound, includes a scale having a platen. The scale is in communication with a user display for displaying an output of the scale. An image capture device having a field of view for capturing at least one image of an object placed on the platen is provided in communication with the user display for displaying the captured image. The platen may include a visual identifier for identifying a portion of the field of view of the image capture device. The platen may also include a tackifier or absorbent material. The platen may be formed of a light-transmissible material. -19 1 31 39 35 37 41 4
Patent AU-2018235153-A1 (AU)
Title: Novel PD-L1 targeting DNA vaccine for cancer immunotherapy
Inventor: LUBENAU HEINZ
IPC: A61K39/00
Filed: 2018-03-16
Abstract: The present invention relates to an attenuated strain of Salmonella comprising at least one copy of a DNA molecule comprising an expression cassette encoding PD-L1. In particular, the present invention relates to said attenuated strain of Salmonella for use in the treatment of cancer.
Patent AU-2018241172-A1 (AU)
Title: Preparation, uses and solid forms of obeticholic acid
Inventor: STEINER ANDRE
IPC: A61P1/16
Filed: 2018-10-05
Abstract: The present invention relates to obeticholic acid, or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic acid is useful for the treatment or prevention of a FXR mediated disease or condition, cardiovascular disease or cholestatic liver disease, and for reducing HDL cholesterol, for lowering triglycerides in a mammal, or for inhibition of fibrosis. The present invention also relates to processes for the synthesis of obeticholic acid.
Patent AU-2018246354-A1 (AU)
Title: Flow distributor
Inventor: DESMET GERT
IPC: B01D15/12
Filed: 2018-03-30
Abstract: A distributor (100) is described for distributing a fluid flow from a smaller to a more broad fluid flow. It comprises a fluid input (110) and a plurality of fluid outputs (120), and a channel structure in between the fluid input (110) and the plurality of fluid outputs (120). The channel structure comprises alternatingly bifurcating channel substructures (132) and common channel substructures (134) wherein said substructures are arranged so that fluid exiting different channels from a bifurcating channel substructure (132) mixes in a subsequent common channel substructure (134), and whereby fluid channels of the bifurcating channel substructure (132) are arranged such that these do not contact the subsequent common channel substructure (134) at the edges thereof.
Patent AU-2018247760-A1 (AU)
Title: Microfluidic device for detection of analytes
Inventor: FORSTER ROBERT
IPC: G01N27/02
Filed: 2018-03-28
Abstract: A microfluidic device for detection of an analyte in a fluid is described. The microfluidic device comprises a substrate having a first surface defining entrances to one or more chambers defined in the substrate, surfaces of the chambers defining a second surface of the substrate, the first surface being modified for selective targeting and capture of at least one analyte to operably effect a blocking of the entrance to at least one of the chambers, and wherein a response characteristic of the microfluidic device is operably varied by the blocking of the entrance to the at least one of the chambers, thereby providing an indication of the presence of the analyte within the fluid.
Patent AU-2018253571-A1 (AU)
Title: Drive mechanism for drug delivery pumps with integrated status indication
Inventor: O'CONNOR SEAN M
IPC: A61M5/145
Filed: 2018-10-25
Abstract: A drive mechanism having integrated status indication includes a drive housing, a status switch interconnect, a drive biasing member, a piston, and a drug container having a cap, a pierceable seal, a barrel, and a plunger seal, wherein the drive biasing member is 5 configured to bear upon an interface surface of the piston. Drive mechanism may include an incremental status stem having a stem interconnect, wherein the stem resides within the drive housing and the piston, and wherein the stem has an interconnect which engages one or more contacts on the piston to provide incremental feedback. A drug delivery pump with integrated status indication includes a housing and an assembly 10 platform, upon which an activation mechanism, an insertion mechanism, a fluid pathway connection, a power and control system, and the drive mechanism having a drug container may be mounted.
Patent AU-2018262528-A1 (AU)
Title: Substituted bicyclic heterocyclic compounds as NADPH oxidase inhibitors
Inventor: KUMAR SUKEERTHI
IPC: A61K31/437
Filed: 2018-05-04
Abstract: The present application relates to substituted fused heteroaryl and heterocyclic compounds, useful as nicotinamide adenine dinucleotide phosphate oxidase inhibitors (NADPH oxidase inhibitors), processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment or prevention of various diseases, conditions and/or disorders mediated by NADPH oxidase. (Formula I)
Patent AU-2018269743-A1 (AU)
Title: Kinase inhibitors and uses thereof
Inventor: DE VICENTE FIDALGO JAVIER
IPC: A61K31/437
Filed: 2018-05-17
Abstract: The present disclosure relates generally to compounds and compositions, intermediates, processes for their preparation, and their use as kinase inhibitors.
Patent AU-2018285351-A1 (AU)
Title: Enzymatic replacement therapy and antisense therapy for Pompe disease
Inventor: VAN DER WAL ERIK
IPC: A61K48/00
Filed: 2018-06-14
Abstract: The invention relates to method for repairing aberrant; splicing, wherein such aberrant: splicing is caused by the pressence of a natural pseudo exon, comprising blocking of either the natural cryptic 3' splice site or t he natural cryptic 5' splice sit e of said natural pseudo exon with an antisense oligomeric compound (AON). Further, the invention comprises an antisense oligomeric compound targeting SEQ ID NO: 1 or SEQ ID NO: 171, preferably selected from the sequences of SEQ ID NO: 267 - 2040, sequences that are complementary to said sequences or sequences that have an identity of 80% with said sequences or the complementary sequences. The invention further envisages the use of two antisense oligomeric compounds, a first AON targeting SEQ ID NO: l and a second targeting AON or SEQ ID NO: 171. These AONs are specifically for use in the treatment of Pompe disease. It is an aspect of the invention that antisense therapy using the above AONs or combinations thereof is used in combination with ERT.
Patent AU-2018291023-A1 (AU)
Title: AAV vector column purification methods
Inventor: OH YOUNGHOON
IPC: B01D15/34
Filed: 2018-06-29
Abstract: Described and provided herein are purification, production and manufacturing methods for recombinant adeno-associated viral (rAAV) vector particles. Purification, production and manufacturing methods set forth herein, for example, include at least 2 column chromatography steps. Column chromatography steps include, for example, cation exchange chromatography, anion exchange chromatography, size exclusion chromatography and/or AAV affinity chromatography alone or in combination and in any order.
Patent AU-2018302088-A1 (AU)
Title: Disc brake with a tensioning device arranged therein and supporting roller for the tensioning device
Inventor: KLAAS THOMAS
IPC: F16D65/18
Filed: 2018-07-05
Abstract: The invention proposes a disc brake having a brake caliper (1) and a tensioning device arranged therein for applying force to the brake linings of the disc brake, wherein part of the tensioning device is a brake lever (10) which can be actuated by a force element and preferably by a compressed air cylinder. The brake lever is composed of a lever arm (14), against which the force element is supported, and a brake application shaft (15), which is supported against a pressure piece (8) acting towards the brake linings, and is also supported from the inside against the brake caliper, wherein the brake caliper (1) and the brake application shaft (15) face each other and are formed as shells (21, 22) in which a supporting roller (20) with a roller axis (A) running transverse to the tensioning direction (Z) is mounted. To keep the mutual movability of the parts involved low by the simplest measures possible and without the need for additional parts, the supporting roller (20) is supported with the lateral surface (20A) thereof directly in one of the two shells (21, 22) and is designed to be non-rotatable or have only limited rotational movement with respect to this shell. The supporting roller (20) also serves as a means to centre the brake lever (10) laterally in the brake caliper. A supporting roller particularly suited to these purposes is also to be created.
Patent AU-2018313318-A1 (AU)
Title: Concrete block system, method and connector
Inventor: LACAS MARC-ANDRÉ
IPC: E04C1/00
Filed: 2018-08-01
Abstract: A concrete block system is provided and allows for the use of a single type of non-integral connector to perform different functions in a mortarless structure, the system comprising a plurality of structural concrete blocks and a plurality of veneer units. The same connector can be used to connect veneer units to structural blocks, to retain the veneer units in different orientations; to create near vertical installations or a setback between stacked rows of structural blocks. In addition, the system provides a single structural block, which can be used for both straight portions or corners of a same structure. The structural block can also be used to create double-sided walls, with opposite lateral walls being configured to received/retain veneer units thereon.
Patent AU-2018335139-A1 (AU)
Title: Fluid treatment systems and methods
Inventor: CLEGG BENJAMIN
IPC: C02F1/02
Filed: 2018-08-24
Abstract: A system for concentrating wastewater with a heated gas is disclosed wherein a heated gas directed into a first wastewater heating chamber at a first velocity and a first wastewater stream is directed into the first wastewater heating chamber. A second wastewater heating chamber coupled to the first wastewater heating chamber and in fluid communication with the first wastewater heating chamber. A second wastewater stream is directed into the second wastewater heating chamber at a velocity that greater than the velocity of the heated gas directed into the first wastewater heating chamber.
Patent AU-2018336995-A1 (AU)
Title: Rechargeable battery jump starting device with control switch backlight system
Inventor: NOOK JONATHAN LEWIS
IPC: H02J7/00
Filed: 2018-09-05
Abstract: A rechargeable battery jump starting device with a control switch backlight system. The control switch backlight system is configured to assist a user viewing the selectable positions of the control switch for selecting a particular 12V or 24V operating mode of the portable rechargeable battery jump starting device in day light, sunshine, low light, and darkness.
Patent AU-2018337748-A1 (AU)
Title: Architecture for defining group messaging
Inventor: NATWICK JASON
IPC: H04B7/185
Filed: 2018-09-19
Abstract: A grouping agent may include processing circuitry configured to receive a device identifier of a communication device associated with a transportation asset, define a communication group including the communication device and one or more other communication devices also associated with the transportation asset, and enable communication of a message to the communication group on the transportation asset.
Patent AU-2018337954-A1 (AU)
Title: Rechargeable battery jump starting device with battery detection system
Inventor: NOOK JONATHAN LEWIS
IPC: H02J7/00
Filed: 2018-09-20
Abstract: A rechargeable battery jump starting device with a vehicle or equipment battery detection system. The vehicle or equipment battery detection system is configured for detecting the connection of the rechargeable battery jump starting device with the vehicle or equipment battery to be jump charged.
Patent AU-2018366371-A1 (AU)
Title: A method for forming a pressure sensor
Inventor: DOYLE CRISPIN
IPC: G01L1/24
Filed: 2018-11-13
Abstract: A method for forming a pressure sensor is provided wherein an optical fibre is provided, the optical fibre comprising a core, a cladding surrounding the core, and a birefringence structure for inducing birefringence in the core. The birefringence structure comprises first and second holes enclosed within the cladding and extending parallel to the core. A portion of the optical fibre comprising the core and the birefringence structure is encased within a chamber, wherein the chamber is defined by a housing comprising a pressure transfer element for equalising pressure between the inside and the outside of the housing. An optical sensor is provided along the core of the optical fibre. The cladding is internally etched by flowing an etchant through the first and second holes along a length of the portion of optical fibre which comprises the optical sensor so as to increase the width of the first and second holes. The chamber is filled with a substantially non-compressible fluid. Consequently, the etched cladding is shaped so as to convert an external pressure provided by the non-compressible fluid within the chamber to an anisotropic stress in the optical sensor.
Patent AU-2018383731-A1 (AU)
Title: Therapy management systems, methods, and devices
Inventor: SJOLUND JOHN
IPC: A61M5/168
Filed: 2018-12-12
Abstract: One or more embodiments of the disclosure are related, generally, to a reusable accessory for a manual medication delivery device. Such a reusable accessory may include a wireless communication interface, a detection circuitry, and a recommendation system. In one or more embodiments, an adapter may be configured to reversibly couple such a reusable accessory to a manual medication delivery device. Dosing events may be detected that are associated with dosing at the manual medication delivery device. Dose recommendations may be provided responsive to analyte measurements and/or dosing events.
Patent AU-2018404657-A1 (AU)
Title: Cleaner
Inventor: HWANG JUNGBAE
IPC: A47L9/16
Filed: 2018-12-31
Abstract: A cleaner, according to the present invention, comprises: a main body for separating dust from air suctioned in through an opening part; a suction motor provided to the main body and generating suction force; and a suction part coupled to the opening part and having a connection pipe for guiding the air to the main body. The main body comprises a suction guide coupled to one side of the connection pipe so as to guide the air suctioned in through the connection pipe to the inner circumferential surface of the main body. The connection pipe comprises a guide duct having a rotatable flap provided thereto. The suction guide is connected to the guide duct. A suction duct comprises: a first surface, which is a surface where the flap is installed; and a second surface facing the first surface. A second extension line of the second surface forms a first angle with a first extension line of one surface, of the suction guide, connected to the second surface. The first extension line and a third extension line of the flap form a second angle, wherein the second angle is equivalent to or smaller than the first angle.