Patent SG-11201807729Y-A (SG)
Title: Use of pneumolysin peptides as antagonists against toll-like receptor 4 and methods of treating toll-like receptor 4 related diseases
Inventor: SIU LEUNG-KEI
IPC: C12N15/31
Filed: 2017-02-24
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11M1111101110101011111 HO 11111 0111011101011101011101101111101111011# International Bureau 0.. .... .. ...... ... (10) International Publication Number (43) International Publication Date WO 2017/152270 Al 14 September 2017 (14.09.2017) WIP0 I PCT (51) (21) (22) (25) Filing Language: (26) Publication Language: (30) (71) (72) (71) Applicant International C07K 14/315 A61K 35/74 (2015.01) A61K 38/16 (2006.01) A61P 3/10 (2006.01) International International Priority Data: 62/305,164 Applicant: KEMYTH BIOTECH No.306, Yuanpei St., Hsinchu Inventor; and #2101 44 St. (CA). Inventors: SIU, chu City, 30015 36, Section 6, (72) Patent Classification: (2006.01) Application Number: Filing Date: 8 March 11490 (TW). LENG, Chih-Hsiang; 35 Keyan Road, C07K 7/06 (2006.01) Zhunan Town, Miaoli County, 350 (TW). C12N 15/31 (2006.01) C12N 15/85 (2006.01) (74) Agents: TOO, Constance et al.; Gowling WLG (Canada) LLP, 160 Elgin Street, Suite 2600, Ottawa, Ontario K11 3 1C3 (CA). PCT/CA2017/050238 (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, 24 February 2017 (24.02.2017) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, English KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 2016 (08.03.2016) US RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, CO., LTD. [CN/CN]; TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, City, 30015 (TW). ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every Pele Choi-Sing [CA/CA]; Apt kind of regional protection available): ARIPO (BW, GH, Toronto, Ontario M4Y 2W4 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, No.306, Yuanpei St., Hsin- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Feng-Yee; 6F, No. 161- LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, East Road, Neihu, Taipei City, [Continued on next page] : CHONG, Joseph Street, Leung-Kei; (TW). CHANG, Min-Chuan — — = = = B loo d g lu cose lev e l (mg /m L) w › - H • o o (0 (54) OF TOLL PNEUMOLYSIN PEPTIDES 111.8 -LIKE RECEPTOR AS 4 RELATED 342.83 ANTAGONISTS AGAINST DISEASES 132.1 TOLL-LIKE RECEPTOR 4 AND METHODS (57) : The present invention relates to isolated peptides from pneumolysin (PLY) and their use as antagonists of toll-like receptor 4 (TLR-4). Bind of said peptides results in de- creased activity of TLR-4. Particularly, the present invention provides isolated peptides from the C-terminal region of PLY which are effective in treatment of TLR-4 related activation condi- tions such as diabetes and atherosclerosis. = OF = = E _— = = — — 1-1 0 IN ei N kr) 1-1 IN 1-1 0 ei Non-DM STZ+ STZ+ control vehicle C7OPLY4 Fig. 3 O WO 2017/152270 Al 1#11101M011010112010EMOMOVINEDIDEOHOMOVOIMIE SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). with sequence listing part of description (Rule 5.2(a)) Published: — with international search report (Art. 21(3))