Patent SG-11201900336Y-A (SG)
Title: Radioligands for imaging the ido1 enzyme
Inventor: DONNELLY DAVID J
IPC: A61K51/04
Filed: 2017-07-18
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111011111111101 IIIIIIIII101111101001111110101H11111110111110111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2018/017529 Al 25 January 2018 (25.01.2018) WI P0 I P C T (51) International Patent Classification: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, A61K 38/00 (2006.01) A61K 51/04 (2006.01) TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (21) International Application Number: (84) Designated States (unless otherwise indicated, for every PCT/US2017/042510 kind of regional protection available): ARIPO (BW, GH, (22) International Filing Date: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 18 July 2017 (18.07.2017) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (25) Filing Language: English EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (26) Publication Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (30) Priority Data: KM, ML, MR, NE, SN, TD, TG). 62/364,020 19 July 2016 (19.07.2016) US Declarations under Rule 4.17: (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY — as to applicant's entitlement to apply for and be granted a [US/US]; Route 206 and Province Line Road, Princeton, patent (Rule 4.17(H)) New Jersey 08543 (US). — as to the applicant's entitlement to claim the priority of the (72) Inventors: DONNELLY, David J.; c/o Bristol-Myers earlier application (Rule 4.17(iii)) Squibb Company, Route 206 and Province Line Road, — of inventorship (Rule 4.17(iv)) Princeton, New Jersey 08543 (US). COLE, Erin Lee; c/o Published: — Bristol-Myers Squibb Company, Route 206 and Province — with international search report (Art. 21(3)) Line Road, Princeton, New Jersey 08543 (US). BURRELL, — Richard Charles; c/o Bristol-Myers Squibb Company, 5 = Research Parkway, Wallingford, Connecticut 06492 (US). = TURLEY, Wesley A.; c/o Bristol-Myers Squibb Compa- ny, 5 Research Parkway, Wallingford, Connecticut 06492 = (US). ALLENTOFF, Alban J.; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). WALLACE, Michael Arthur; c/ — o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). BALOG, James Aaron; c/o Bristol-Myers Squibb Company, Route = = 206 and Province Line Road, Princeton, New Jersey 08543 (US). HUANG, Audris; c/o Bristol-Myers Squibb Com- pany, Route 206 and Province Line Road, Princeton, New = Jersey 08543 (US). SKINBJERG, Mette; c/o Bristol-My- ers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). = Agent: FARQUHARSON-TORRES, Serena et al.; Bris- tol-Myers Squibb Company, Route 206 and Province Line (74) = Road, Princeton, New Jersey 08543 (US). Designated States (unless otherwise indicated, for every (81) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, = _ 1-1 01 ei kin IN 1-1 © —.... 00 1-1 (54) Title: RADIOLIGANDS FOR IMAGING THE IDO1 ENZYME © ei (57) : The present invention relates to radiolabeled IDO1 inhibitors or pharmaceutically acceptable salts thereof which are 0 useful for the quantitative imaging of IDO enzymes in mammals.