Patent SG-11201900464T-A (SG)
Title: HUMANIZED MONOCLONAL ANTIBODIES THAT TARGET VE-PTP (HPTP-ß)
Inventor: PETERS KEVIN
IPC: C12N15/13
Filed: 2017-07-19
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property C.--.` Organization 1 MEM 0 11101 HOE HI 1 0 0111111010 HO HE 010 HAIM 011 International Bureau (10) International Publication Number (43) International Publication Date .../- WO 2018/017714 Al 25 January 2018 (25.01.2018) WIP0 I PCT (51) International Patent Classification: (74) Agent: OH, Young In et al.; Wilson Sonsini Goodrich & A61K 38/02 (2006.01) C07K 16/28 (2006.01) Rosati, 650 Page Mill Road, Palo Alto, California 94304 A61K 39/395 (2006.01) C07K 16/32 (2006.01) (US). A61K 51/10 (2006.01) C12N 9/96 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01) (81) Designated States (unless otherwise indicated, for every CO7K 16/24 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (21) International Application Number: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, PCT/US2017/042855 DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (22) International Filing Date: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, 19 July 2017 (19.07.2017) KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 62/364,381 20 July 2016 (20.07.2016) US kind of regional protection available): ARIPO (BW, GH, 62/377,072 19 August 2016 (19.08.2016) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (71) Applicant: AERPIO THERAPEUTICS, INC. [US/US]; UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 9987 Carver Road, Suite 420, Cincinnati, Ohio 45242 (US). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, — EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (72) Inventors: PETERS, Kevin; 9160 Given Road, Cincinnati, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = Ohio 95243 (US). FLYNN, Michael Allen; 3890 High- TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, lander Way West, Ann Arbor, Michigan 48108 (US). KM, ML, MR, NE, SN, TD, TG). Title: HUMANIZED MONOCLONAL ANTIBODIES THAT TARGET VE-PTP (54) (HPTP-B) = = 1 5D = - (SEQ ID NO: 50) VHO EVQLVETGGGLVQPKGSMKLSCAASGFTFNANAMNWIRQAPGKGLEWVAR - (SEQ ID NO: 9) VH1 EVQLVESGGGLVQPGGSLKLSCAASGFTFNANAMNWVRQASGKGLEWVGR (SEQ ID NO: 10) VH2 EVQLVESGGGLVQPGGSLRLSCAASGFTFNANAMNWVRQAPGKGLEWVGR = (SEQ ID NO: 11) VH3 EVQLVESGGGLVQPGRSLRLSCTASGFTFNANAMNWVRQAPGKGLEWVGR (SEQ ID NO: 12) VH4 LVQLVESGGGLVKPGGSLRLSCAASGFTFNANAMNWIRQAPGKGLEWVSR = 51 100 = - (SEQ ID NO: 50) VE0 IRTKSNNYATYYAGSVKDRFTIORDDAQNMLYLOMNDLKTEDTAMYYOVR _ (SEQ ID NO: 9) VH1 IRTKSNNYATYYAGSVKDRFTIORDOSKNTAYLOMNSIKTEDTAAYYCVR = (SEQ ID NO: 10) VH2 IRTKSNNYATYYAGSVKDRFTISRDOSKNSLYLQMNSINTEDTAVYYCVR = (SEQ ID NO: 11) VH3 IRTKSNNYATYYAGSVKDRFTISRDOSKNIAYLQMNSINTEDTAVYYCVR = (SEQ ID NO: 12) VH4 IRTKSNNYATYYAGSVKDRFTISRONAKNSLYLQMNSLRAEDTAVHYCVR = 101 122 - (SEQ ID NO: 50) VHO DYYGSSAWITYWGQGTLVTVSA = (SEQ ID NO: 9) VHI DYYGSSAWITYWGQGTLVTVSS (SEQ ID NO: 10) VH2 DYYGSSAWITYWGQGTLVTVSS (SEQ ID NO: 11) VH3 DYYGSSAWITYWGQGTLVTVSS - (SEQ ID NO: 12) VH4 DYYGSSAWITYWGQGTLVTVSS 11 FIGURE 1 1 1' 11 IN IN 11 © --.... GC 11 N (57) : The disclosure provides compositions and methods for the treatment of ocular conditions associated with angiogenesis _ comprising administering an antibody that targets a tyrosine phosphatase inhibitor in a subject. [Continued on next page] WO 2018/017714 Al MIDEDIMOMMIDIREIENIRMEMOIDHEMOVOIS Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of