baber/WOPTO huggingface dataset:
Patent MX-PA02009585-A (MX)
Title: Use of polyphosphate as a tooth erosion inhibitor in acidic compositions.
Inventor: PARKER DAVID MYATT
IPC: A23L1/304
Filed: 2001-03-23
Abstract: The use of polyphosphate in acidic oral compositions, especially acid beverages with a pH between 2. 2 and 5.5, to alleviate or prevent the tooth damage associated with the consumption of acid. The invention may be practised using polyphosphate alone or in combination with calcium and or viscosity modifying polymers.
Patent MX-PA03001047-A (MX)
Title: Derivatives of variolin b.
Inventor: ALVAREZ MERCEDES
IPC: A61P35/00
Filed: 2001-08-03
Abstract: The invention provides antitumour compounds of formula (I), wherein R1 is an aromatic substituent; R2 is hydrogen or a substituent when the dotted line is absent, or R2 is absent when the dotted line represents a bond to give a double bond between the nitrogen which bears R2 and the carbon which bears R3; R3 is an oxo group = O when the dotted line is absent or is a substituent when the dotted line represents a bond to give a double bond between the nitrogen bearing R2 and the carbon bearing R3; R4 is hydrogen or a substituent; and pharmaceutically acceptable salts thereof.
Patent MX-PA03001632-A (MX)
Title: Selective androgen receptor modulators and methods of use thereof.
Inventor: YIN DONGHUA
IPC: C07C235/24
Filed: 2001-08-23
Abstract: This invention provides a novel class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds which are tissue-selective androgen receptor modulators (SARM), which are useful for oral testosterone replacement therapy, male contraception, maintaining sexual desire in women, treating prostate cancer and imaging prostate cancer. These agents have an unexpected in-vivo activity for an androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. These agents may be active alone or in combination with progestins or estrogens. The invention further provides a novel class of non-steroidal agonist compounds. The invention further provides compositions containing the selective androgen modulator compounds or the non-steroidal agonist compounds and methods of binding an androgen receptor, modulating spermatogenesis, treating and imaging prostate cancer, and providing hormonal therapy for androgen-dependent conditions.
Patent MX-PA03002493-A (MX)
Title: Efficient process for the preparation of a factor xa inhibitor.
Inventor: SUNKARA HARI BABU
IPC: A61K/
Filed: 2001-09-12
Abstract: The present invention relates to the process for the preparation of the compound of Formula (I), from its corresponding 3-cyano-4-fluorophenyl-pyrazole and intermediates useful therein.
Patent MX-PA03007467-A (MX)
Title: Tramadol-based medicament.
Inventor: BARTHOLOMEUS JOHANNES
IPC: A61P13/10
Filed: 2002-02-20
Abstract: The invention relates to a medicament containing the racemate of tramadol in a retarded form and the (+)-enantiomer of tramadol in a non-retarded form.
Patent MX-PA03007699-A (MX)
Title: Diaminoquinazoline esters for use as dihydrofolate reductade inhibitors.
Inventor: LUNDSTEDT TORBJ RN
IPC: C07D407/12
Filed: 2002-02-28
Abstract: Compounds of the formula (I) wherein R1, R2, R1 and R2 are independently hydrogen or a group releasing the free aminein vivo, R6 is a substituted phenyl or an optionally substituted, bicyclic or tricyclic aryl ring system or an optionally substituted mono, bi- or tricyclic heteroaryl ring system having utility as dihydrofolate reductase (DHFR) inhibitors with favourable pharmacokinetic properties.
Patent MX-PA04005646-A (MX)
Title: Process and intermediates for pyridazinone antidiabetic agents.
Inventor: NORMA JAQUELINE TOM
IPC: A61P27/02
Filed: 2003-01-03
Abstract: The present invention relates to a process for preparing pyridazinone aldose reductase inhibitors which are useful in the prevention and/or treatment of diabetic complications such as diabetic neuropathy, diabetic retinopathy, diabetic nephropathy, diabetic cardiomyopathy, diabetic microangiopathy and diabetic macroangiopathy in mammals. The invention also relates to novel intermediates useful in preparing those aldose reductase inhibitors.
Patent MX-PA04007208-A (MX)
Title: Riser buoyancy system.
Inventor: METIN KARAYAKA
IPC: E21B17/01
Filed: 2003-01-30
Abstract: A frame and system for adding buoyancy to a riser used in connection with floating platforms is provided which comprises at least two substantially longitudinally and substianlly radially extending members (33). In some example embodiments, the system includes a stem attached to multiple supports which include flanges arranged to take impact and abrasion loads off an internal buoyancy module. An air management system is also provided.
Patent MX-PA04007502-A (MX)
Title: Quinoline derivatives as npy antagonists.
Inventor: PATRIZIO MATTEI
IPC: A61P3/10
Filed: 2003-01-27
Abstract: Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, R4 and A have the significance given in claim 1, can be used in the form of pharmaceutical preparations for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.
Patent MX-PA04008681-A (MX)
Title: Oxo-azabicyclic compounds.
Inventor: YUE WEN-SONG
IPC: C07D403/06
Filed: 2003-03-06
Abstract: A compound selected from those of formula (I) wherein: X1, X2, and X3, represent N or -CR3 in which R3 is as described in the description, G1 represents a group selected from those of formulae (i/a) and (i/b) in which R4, R5, and R6 are as defined in the description, G2 represents a group selected from carbon-carbon triple bond, -CH=C=CH-, C=O, C=S, S(O)n1 in which nl represents an integer from 0 to 2 inclusive, or a group of formula (i/c) in which Y1 represents O, S, -NH or -Nalkyl, and Y2 represents O, S, -NH or -Nalkyl, n is an integer from 0 to 6 inclusive, and m is an integer from 0 to 7 inclusive, Z1 represents -CR9R10,wherein R9 and R10 are as defined in the description, A represents a ring system, R1 represents a group selected from H, alkyl, alkenyl, alkynyl, optionally substituted and the group of formula (i/d) in which p, Z2, B, q and G3 are as defined in the description and optionally, its optical isomers, N-oxide, and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are useful as specific inhibitors of type-13 matrix mettaloprotease.
Patent MX-PA04012318-A (MX)
Title: Application catalog on an application server for wireless devices.
Inventor: SAMIR K KHAZAKA
IPC: G06Q30/02
Filed: 2003-07-01
Abstract: A system, method, and computer program for providing an application catalog (72) of served applications and data to wireless devices (60) on a wireless network (62) seeking to download the applications and/or data. The application catalog is displayable to a wireless device across the wireless network, and application lists at least a plurality of application catalog is optimized based upon predetermined criteria such that the preferred application and/or data to be downloaded by a wireless device is initially displayed to a wireless device attempting to access the application catalog.
Patent MX-PA05000087-A (MX)
Title: Flexible package having a self-supporting extension.
Inventor: KONDO MASAHIRO
IPC: B65D33/00
Filed: 2003-06-30
Abstract: A flexible package for compressible absorbent articles, where the flexible package comprises a self-supporting extension that captures consumer attention and provides acceptable shipping and storage dimensions.
Patent MX-PA05001049-A (MX)
Title: Method to improve the stability of lemon/lime flavored beverages.
Inventor: BELL ZENA
IPC: A23L2/02
Filed: 2003-07-29
Abstract: A combination of an acidulant system and a buffer salt system is included in lemon/lime flavored beverages to achieve improved stability. The acidulant system includes citric acid and/or phosphoric acid and an additional organic acid having a smaller dissociation constant than both phosphoric acid and citric acid; the buffer salt system includes a citrate salt and a phosphate salt.
Patent MX-PA05002921-A (MX)
Title: Turbine components with thermal barrier coatings.
Inventor: DAVID A LITTON
IPC: C09D7/80
Filed: 2005-03-16
Abstract: A turbine component has a substrate formed from a ceramic material selected from the group consisting of a monolithic ceramic material and a composite ceramic material and a thermal barrier coating bonded to the substrate. In one embodiment, the ceramic material forming the substrate is selected from the group of silicon nitride and self-reinforced silicon nitride. In another embodiment, the ceramic material forming the substrate is selected from the group consisting of a silicon carbide-silicon carbide material and a carbon-carbon material. At least one bond coat layer may be interposed between the substrate and the thermal barrier coating.
Patent MX-PA05003002-A (MX)
Title: Method for producing acylated peptides.
Inventor: JENSEN INGE HOLM
IPC: C07K14/605
Filed: 2003-09-25
Abstract: The present invention provides a method for acylating one or more amino groups of a peptide where the acylation reaction is to be performed in an aqueous mixture containing less than 10 %w/w aprotic polar solvent. a) reacting the peptide having at least one free amino group with an acylating agent of the general formula I wherein n, is 0-8 R1is COOR4; R2 is a lipophilic moiety; R3 together with the carboxyl group to which R3 is attached designate a reactive ester or a reactive N-hydroxy imide ester; and R4 is selected from hydrogen, C1-12-alkyl and benzyl, under basic conditions in an aqueous mixture;.
Patent MX-PA05003664-A (MX)
Title: Alpha 2b 0r 2b/2c adrenoceptor agonists for the treatment of neurodegeneration.
Inventor: JOHN E DONELLO
IPC: A61K31/137
Filed: 2003-10-07
Abstract: Methods of preventing or retarding the degeneration of neurons. Also disclosed are methods for treating Alzheimer's disease or Parkinson's disease through the administration of selective alpha 2B or alpha 2B/2C receptor agonists, hereby incorporated by reference herein.
Patent MX-PA05006561-A (MX)
Title: Apparatus and method for characterizing a reservoir.
Inventor: CAMPO CHRISTOPHER DEL
IPC: E21B49/10
Filed: 2005-06-17
Abstract: An apparatus and method for characterizing a subsurface formation is provided. The apparatus includes a tool body, a probe assembly carried by the tool body for sealing off a region of the borehole wall, an actuator for moving the probe assembly between a retracted position for conveyance of the tool body and a deployed position for sealing off a region of the borehole wall and a perforator extending through the probe assembly for penetrating a portion of the sealed-off region of the borehole wall. The tool may be provided with first and second drilling shafts with bits for penetrating various surfaces. The method involves sealing off a region of a wall of an open borehole penetrating the formation, creating a perforation through a portion of the sealed-off region of the borehole wall and testing the formation.
Patent MX-PA05007252-A (MX)
Title: Pressure relieved thread connection.
Inventor: CURTIS J PARKER
IPC: F16L15/06
Filed: 2003-12-15
Abstract: Lubricant escape passages are formed in the threads used to connect one tubular body to another. The passages conduct trapped thread lubricant out of the threaded area to prevent the creation of high lubricant pressure that may damage or cause improper make up of the threaded connection. The passages may be grooves in the crests of the thread teeth and/or may be corner bevels on the thread teeth. In a conductor pipe or other pipe assembly using axially spaced internal and external seals at each axial end of the threaded area, the escape passages form a helical flow path through the engaged thread area. The external seal prevents the entry of corrosive fluids into the threaded area and the internal seal prevents leakage through the threaded area from within the conductor pipe. When the lubricant pressure increases excessively during assembly or impact loading of the connection, the lubricant escapes past the seals to prevent connection damage.
Patent MX-PA05007525-A (MX)
Title: Polyisocyanates with improved compatibility with high hydroxyl content polyols.
Inventor: ZIELINSKI DAVID P
IPC: C08G18/80
Filed: 2005-07-13
Abstract: A composition that includes a mixture of A) a prepolymer of aliphatic isocyanates adducted with an active hydrogen functional compound containing a polar group; and B) a polyol containing at least four active hydrogen groups. The mixture does not separate into two phases after standing at room temperature for two hours. The composition can be used to coat a substrate by applying the above described composition to at least a portion of a surface of the substrate.
Patent MX-PA05009124-A (MX)
Title: Improvements in and relating to drive mechanisms suitable for use in drug delivery devices.
Inventor: STEVEN WIMPENNY
IPC: A61M5/24
Filed: 2004-03-03
Abstract: The invention relates to a drive mechanism for use in a drug delivery device comprising: a housing (2) having an internal and an external thread; a piston rod (32) having a non-circular cross section, and which is threadedly engaged with the internal thread of the housing (2); a unidirectional coupling located between the housing (2) and the piston rod (32); a dose dial sleeve (50), which is threadedly engaged with the external thread of the housing (2) and being rotatable with respect to the housing (2); a drive sleeve (60), located between the housing (2) and the piston rod (32), which is axially displaceable but not rotatable with respect to the piston rod (32); and a clutch means located between the drive sleeve (60) and the dose dial sleeve (50). When the dose dial sleeve (50) and the drive sleeve (60) are de-coupled by the said clutch means, rotation of said dose dial sleeve (50) with respect to the said drive sleeve (60) is allowed. When the dose dial sleeve (50) and drive sleeve (60) are coupled by the said clutch means, rotation of the dose dial sleeve (50) with respect to the said drive sleeve (60) is prevented.
Patent MX-PA05010290-A (MX)
Title: A device for slowing the movement of a door, drawer or similar movable member, having releasable locking means.
Inventor: CULTRARO ANTONINO
IPC: E05C19/02
Filed: 2003-09-08
Abstract: A device (15) for slowing the movement of a door (2) urged by unidirectional thrust means (4), including a casing (17) fixable to a structure (S) and defining a chamber (18) filled with a viscous fluid, and a rotor (31). The rotor (31) includes a disc portion (32) and a shaft portion (33) protruding through the lid (21) of the casing (17) in such a way as it can be associated with the door (2). The base surface (23a) of the chamber (18) has a recess (51) operable to house a pivotable arm (52). The arm (52) has a pin portion (54) protruding into the chamber (18). The lower surface (62) of the disc portion (32) of the rotor (31) has a groove (70) for engaging the pin portion (54) of the arm (52). At one end (73), the groove (70) has a cam (76) dividing it into a return path (75) and a forward path (74) for the pin portion (54) so as to define a locking position foe the rotor (31) in cooperation with the thrust means (4).
Patent MX-PA05010961-A (MX)
Title: Apparatus and method for mechanically bonding and cutting an article.
Inventor: DAVID J VAN EPEREN
IPC: A61F13/15
Filed: 2004-01-20
Abstract: In a method and apparatus for mechanically bonding and cutting an article during assembly thereof at least a portion of the article is transported through a nip defined by first and second members. A bonding segment is disposed on one of the first and second members and a cutting segment separate from the bonding segment is also disposed on one of the first and second members. The apparatus is operable so that a portion of the article is mechanically bonded as the article passes through the nip and a portion of the article separate from the bonded portion is cut as the article passes through the nip.
Patent MX-PA05012227-A (MX)
Title: Enhanced vsb viterbi decoder.
Inventor: KANG KYUNG WON
IPC: H04L27/01
Filed: 2005-11-14
Abstract: An enhanced VSB receiver includes a tuner which tunes an RF signal and converts it into an IF signal, an IF mixer which converts the IF signal into a baseband signal, and a demodulator which demodulates the baseband signal signal into a VSB signal. The enhanced VSB receiver further includes a map recovery unit which recovers VSB map information of the VSB signal, an enhanced equalizer for compensating channel distortion of the VSB signal and outputting an equalized symbol, and an enhanced Viterbit decoder for estimating whether polarity inversion occurred during a symbol period of the equalized symbol and Viterbi-decoding the equalized symbol based on the polarity estimation.
Patent MX-PA06001041-A (MX)
Title: Selective handling of user equipment.
Inventor: NOLDUS ROGIER AUGUST
IPC: H04W12/06
Filed: 2004-07-30
Abstract: The invention relates to a method and device for selective handling of user equipment in a telecommunications network. The method comprises the steps of receiving (S101) a service request, determining (S102, S106, S107) a user equipment identifier, requesting (S103, S108) a user equipment attribute, receiving (S104, S109) the user equipment attribute, and initiating (S111) an appropriate action based on the user equipment attribute.
Patent MX-PA06004082-A (MX)
Title: 2-phenyl-benzofuran derivatives, method for the production thereof and their use.
Inventor: TOTI LUIGI
IPC: C07D307/86
Filed: 2004-10-16
Abstract: The invention relates to 2-phenyl-benzofuran compounds of formula (I), which are formed by the microorganism Aspergillus flavipes ST003878 (DSM 15290) during fermentation, to a method for the production thereof and to their use as medicaments for treating and/or preventing bacterial infectious diseases or mycoses.
Patent MY-101559-A (MY)
Title: Appartus for and methods of providing a multiplicity of streams of air entrained fibers.
Inventor: JOGN J ANGSTADT
IPC: A61F13/49
Filed: 1987-05-21
Abstract: APPARATUS FOR AND METHODS OF PROVIDING A MULTIPLICITY OF STREAMS OF AIR- ENTRAINED FIBERS.THE APPARATUS IS OF THE TYPE WHICH INCLUDES A SPLITTING MEMBER HAVING MULTIPLE PORTS DISPOSED ALONG THE SPLITTING MEMBER ;A FIRST CONDUIT MEANS SUCH AS A CONDUIT DUCT FOR DIRECTING A COLUMN OF AIR PAST A FIRST PORT,THE FIRST CONDUIT MEANS BEING IN COMMUNICATION WITH THE FIRST PORT; AND A SECOND CONDUIT MEANS SUCH AS A CONDUIT DUCT FOR DIRECTING A COLUMN OF AIR PAST A SECOND PORT, THE SECOND CONDUIT MEANS BEING IN COMMUNICATION WITH THE SECOND PORT. THE METHOD PREFERABLY COMPRISES THE STEPS OF:(A)DIRECTING A COLUMN OF FIBERS ALONG A SPLITTING MEMBER HAVING A FIRST PORT AND A SECOND PORT;(B)DIRECTING A COLUMN OF AIR THROUGH A FIRST CONDUIT MEANS AND PAST THE FIRST PORT SO AS TO DRAW A PORTION OF THE FIBER COLUMN INTO THE FIRST CONDUIT MEANS TO FORM A FIRST FIBER STREAM;(C)ENTRAINING THE FIRST FIBER STREAM IN THE AIR;(D)DIRECTING THE FIRST FIBER STREAM DOWNSTREAM;(E)DIRECTING A COLUMN OF AIR THROUGH A SECOND CONDUIT MEANS AND PAST A SECOND PORT SO AS TO DRAW PORTION OF THE COLUMN OF FIBERS INTO THE SECOND CONDUIT MEANS TO FORM A SECOND FIBER STREAM;(F)ENTRAINING THE SECOND FIBER STREAM IN THE AIR; AND (G)DIRECTING THE SECOND FIBRE STREAM DOWNSTREAM.(FIG. 1)
Patent MY-101849-A (MY)
Title: Improvements in or relating to cyanopyrazole herbicides.
Inventor: JAMES RICHARD BECK
IPC: C07D231/16
Filed: 1987-09-18
Abstract: THE PRESENT INVENTION IS DIRECTED TO COMPOUNDS OF THE FORMULA.WHERE R1 IS C1-C6 ALKYL, C5-C6 CYCLOALKYL,EACH OF R2 AND R3 IS TAKEN SEPARATELY AND IS INDEPENDENTLY HYDROGEN, C1-C4 ALKYL, C3-C4 ALKENYL, C3-C4 ALKYNYL, C3-C4 CYCLOALKYL OR C1-C3 ALKOXY, OR R2 AND R3 ARE TAKEN TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED AND FORM PIPERIDINE, MORPHOLINE OR PYRROLIDINE; EACH R4 INDEPENDENTLY IS HALOGEN, C1-C4 ALKYL, C1-CPHD 4 ALKOXY, C1-C4 HALOALKYL, C1-C4 HALOALKOXY OR CYANO; X IS 0 OR S; AND M IS 0-3; WITH THE PROVISOS THAT WHEN R4 IS C1-C4 ALKYL, THAT SUBSTITUENT EXISTS AT OTHER THAN THE 2 OR 6 POSITION OF THE PHENYL RING; WHEN R2 IS C1-C3 ALKOXY, R3 IS OTHER THAN C1-C3 ALKOXY. THESE COMPOUNDS EXHIBIT ACTIVITY AS TERRESTRIAL HERBICIDES AQUATIC HERBICIDES, AND AQUANTIC ALGICIDES.
Patent MY-103920-A (MY)
Title: (alpha),(alpha)-disubstituted aromatics and heteroaromatics as cognition enhancers
Inventor: RICHARD ALAN EARL
IPC: A61K31/54
Filed: 1988-10-05
Abstract: COGNITIVE DEFECIENCIES OR NEUROLOGICAL DYSFUNCTION IN MAMMALS ARE TREATED WITH ALPHA, ALPHA-DISUBSTITUTED AROMATIC OR HETEROAROMATIC COMPOUNDS. THE COMPOUNDS HAVE THE FORMULA; (FORMULA 1)OR A SALT THEREOF WHEREIN X AND Y ARE TAKEN TOGETHER TO FORM A SATURATED OR UNSATURATED CARBOCYCLIC OR HETEROCYCLIC FIRST RING AND THE SHOWN CARBON IN SAID RING IS ALPHA TO AT LEAST ONE ADDITIONAL AROMATIC RING OR HETEROAROMATIC RING FUSED TO THE FIRST RING; ONE OF HET1 OR HET2 IS 2,3, OR 4-PYRIDYL OR 2, 4 OR 5-PYRIMIDINYL AND THE OTHER IS SELECTED FROM(A)2,3 OR 4-PYRIDYL(B)2,4, OR 5-PYRIMIDINYL(C)2-PYRAZINYL(D)3, OR 4-PYRIDAZINYL(E)3, OR 4-PYRAZOLYL(F)2, OR 3-TETRAHYDROFURANYL AND(G)3-THIENYL.
Patent MY-103780-A (MY)
Title: Bicyclic peroxides
Inventor: GERALD SCHMID
IPC: C07D405/06
Filed: 1988-10-06
Abstract: THE NOVEL BICYCLIC PEROXIDES OF THE GENERAL FORMULA(FORMULA. 1)WHEREIN R SIGNIFIES A SATURATED OR PARTIALLY UNSATURATED HYDROCARBON GROUP WITH UP TO 15 CARBON ATOMS OR AN ARYL, HETEROARYL, ARYLCARBONYL OR HETEROARYL-CARBONYL GROUP ATTACHED VIA AN ALKYL OR ALKENYL GROUP WITH UP TO 7 CARBON ATOMS, POSSESS VALUABLE PHARMACOLOGICAL PROPERTIES. IN PARTICULAR, THEY EXHIBIT A PRONOUNCED ACTIVITY AGAINST THE CAUSATIVE ORGANISM OF MALARIA AND CAN BE USED FOR THE PREVENTION AND CONTROL OF MALARIA.
Patent MY-106282-A (MY)
Title: New piperazinylalkyl-3(2h)-pyridazinones, process for the preparation thereof and the use thereof as agents lowering blood pressure.
Inventor: DR HEINZ BLASCHKE
IPC: C07D401/12
Filed: 1989-11-29
Abstract: THE INVENTION RELATES TO NEW PIPERAZINYLALKYL-3 (2H) -PYRIDAZINONES OF THE FORMULA 1 IN WHICH THE RADICALS R1 REPRESENTS HYDROGEN, PHENYL, BENZYL, OR (C1-C6)-ALKYL WHICH IS UNSUBSTITUTED OR SUBSTITUTED ONE OR MORE TIMES BY HYDROXYL, PIPERIDINE, MORPHOLINE OR BY A GROUP NR4R5 IN WHICH R4 AND R5 CAN BE IDENTICAL OR DIFFERENT AND WHICH REPRESENT HYDROGEN, METHYL OR ETHYL, R2 AND R3 REPRESENT HYDROGEN, HALOGEN, (C1-C6)-ALKOXY OR (C1-C6)-ALKYL, WHERE AT LEAST ONE OF THE RADICALS R2 AND R3 DENOTES HYDROGEN, R6 REPRESENTS HYDROGEN, (C1-C4)-ALKYL, PHENYL, BENZYL OR PHENYLETHYL, B REPRESENTS (C1-C7)-ALKYLENE WHICH IS UNSUBSTITUTED OR SUBSTITUTED ONE OR MORE TIMES BY HYDROXYL, (C1-C4)-ALKYL OR BY THE GROUP NR4N5 AND WHICH CAN OPTIONALLY BE CLOSED TO FORM AN ALICYCLIC 4- TO 7-MEMBERED RING, R8 AND R9 WHICH CAN BE IDENTICAL OR DIFFERENT, REPRESENT HYDROGEN OR (C1-C6)-ALKYL AND Z REPRESENTS PHENYL, NAPTHYL, PYRIDYL OR THIAZOLYL EACH OF WHICH CAN BE UNSUBSTITUTED OR SUBSTITUTED ONE OR MORE TIMES BY (C1-C6)-ALKYL, (C1-C6)-ALKOXY, BENZYLOXY, TRIFLUOROMETHYL, HALOGEN, NITRO, (C3-C7)-CYCLOALKOXY, (C1-C4)-ALKYLTHIO, TRIFLUOROMETHYLTHIO OR BY THE GROUP NR4R5,THE PHARMACEUTICALLY UTILIZABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF AS MEDICAMENT FOR THE TREATMENT OF HYPERTENSION, CARDIAC INSUFFICIENCY AND DISTURBANCES OF PERIPHERAL CIRCULATION.