Patent SG-11201806282X-A (SG)
Title: High-throughput identification of patient-specific neoepitopes as therapeutic targets for cancer immunotherapies
Inventor: NGUYEN ANDREW
IPC: G01N33/574
Filed: 2017-02-10
Abstract: 200000 6 150000 100000 50000 0 Detection: DNA RNA netMHC A'02:01 Restricted Samples Necepitopes EUCEC (14) ! THCA (10) 1STAD (1) _j READ (4) OPRAD (10) LUSC (15) LUAD (17) Ej KIRC (13) DHNSC (25) 3COAD (3) BRCA (28) BLCA (3) Cancer Gene Classification of Neoepitopes Non-Cancer Genes 1:1 Cancer Driving Genes 94% FIG. 2 W O 20 17 / 13969 4 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/139694 Al 17 August 2017 (17.08.2017) WIPO I PCT 111111111111110111011111111111010111110 0111011111011111111101111111111111110111111 (51) International Patent Classification: GOOF 19/18 (2011.01) A61K 39/00 (2006.01) C12Q 1/68 (2006.01) A61K 39/395 (2006.01) GO1N 33/569 (2006.01) A61K 47/50 (2017.01) GO1N 33/574 (2006.01) A61K 48/00 (2006.01) A61K 35/17 (2014.01) (21) International Application Number: PCT/US2017/017549 (22) International Filing Date: 10 February 2017 (10.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/294,665 12 February 2016 (12.02.2016) US (71) Applicants: NANTOMICS, LLC [US/US]; 9920 Jeffer- son Boulevard, Culver City, CA 90232 (US). NANT HOLDINGS IP, LLC [US/US]; 9920 Jefferson Boulevard, Culver City, CA 90232 (US). = (72) Inventors: NGUYEN, Andrew; 9920 Jefferson Boulevard, Culver City, CA 90232 (US). SANBORN, John, Zachary; 9920 Jefferson Boulevard, Culver City, CA 90232 (US). BENZ, Stephen, Charles; 436 Park Way, Santa Cruz, CA 95062 (US). NIAZI, Kayvan; 9920 Jeffer- son Boulevard, Culver City, CA 90232 (US). RABIZA- DEH, Shahrooz; 9920 Jefferson Boulevard, Culver City, CA 90232 (US). SOON-SHIONG, Patrick; 9920 Jeffer- son Boulevard, Culver City, CA 90232 (US). VASKE, Charles, Joseph; 9920 Jefferson Boulevard, Culver City, CA 90232 (US). (74) Agents: FESSENMAIER, Martin et al.; Fish & Tsang, LLP, 2603 Main Street, Suite 1000, Irvine, CA 92614 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, [Continued on next page] (54) Title: HIGH-THROUGHPUT IDENTIFICATION OF PATIENT-SPECIFIC NEOEPITOPES AS THERAPEUTIC TARGETS FOR CANCER IMMUNOTHERAPIES (57) : Systems and methods are presented that allow for selection of tumor neoepitopes that are filtered for various criteria. In particularly contemplated aspects, filtering includes a step in which the mutation lead- ing to the neoepitope is ascertained as being located in a cancer driver gene. WO 2017/139694 Al MIDEDIMOMOIDEIR010130111001MOIMOIMMEHOIMI TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with amended claims (Art. 19(1))