baber/WOPTO huggingface dataset:
Patent IL-132366-A0 (IL)
Title: Methods for identifying compounds for inhibition of neoplastic lesions and pharmaceutical compositions containing such compounds
IPC: G01N33/566
Filed: 1999-10-13
Abstract: There is disclosed a pharmaceutical composition for the treatment of neoplasia, comprising a pharmaceutically acceptable carrier and a compound selected by: determining the cyclooxyegenase (COX) inhibitory activity of the compound; determining the PDE inhibition activity of the compound wherein the PDE is characterized by: (a) cGMP specificity over cAMP; (b) positive cooperative kinetic behaviour in the presence of cGMP substrate; (c) submicromolar affinity for cGMP; and (d) insensitivity to incubation with purified cGMP-dependent protein kinase; and selecting the compound that has COX inhibitory activity lower than said PDE activity for treating neoplasia. Also provided by the invention is a method for selecting a compound the treatment of neoplasia, comprising determining the cyclooxygenase (COX) inhibitory activity of the compound; determining the PDE2 inhibition activity of the compound; and selecting the compound that has COX inhibitory activity lower than said PDE activity for treating neoplasia.
Patent IL-136539-A0 (IL)
Title: Savoury cereal
IPC: A23L7/17
Filed: 2000-06-02
Abstract: Cooked-extruded-expanded savoury cereal having a porous texture and a specific weight of from 100 to 500 g/l, especially of from 150 to 350 g/l, which may be added alone or as part of a fix to eggs for preparing an egg based product, especially an omelet or scrambled eggs.
Patent IL-144138-A0 (IL)
Title: Milling cutter and cutting insert therefor
IPC: B23C3/08
Filed: 2001-07-04
Abstract: An indexable cutting insert for use in a milling cutter. The cutting insert having four identical side surfaces extending between generally square shaped top and bottom surfaces with two diametrically opposite protuberances extending away from each other in a top or bottom view of the cutting insert. The cutting insert has eight identical major and minor cutting edges. The milling cutter having the general form of a circular disk with a plurality of the cutting inserts releasably mounted in insert pockets angularly around the periphery of the cutter. The cutting inserts are arranged to produce a profile on a workpiece having a central straight section and two beveled sections on either side of the central straight section.
Patent IL-144725-A0 (IL)
Title: Novel guanidine derivatives as inhibitors of cell adhesion
IPC: A61K31/506
Filed: 2000-02-04
Abstract: The present invention relates to acylguanidine derivatives of the formula I, <CHEM> in which R<1>, R<2>, R<4>, Ar, X and n have the meanings indicated in the claims, their physiologically tolerable salts and their prodrugs. The compounds of the formula I are valuable pharmacologically active compounds. They are vitronectin receptor antagonists and inhibitors of cell adhesion and inhibit bone resorption by osteoclasts. They are suitable, for example, for the therapy and prophylaxis of diseases which are caused at least partially by an undesired extent of bone resorption, for example osteoporosis. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
Patent IL-156266-A0 (IL)
Title: A substance or composition for the treatment of cancer
IPC: A61P35/04
Filed: 2001-11-29
Abstract: A substance for use in the treatment of cancer, includes a compound selected from metallocenyl beta-diketones Mc-CO-CZ1Z2-CO-R. Mc is Fc (ferrocenyl), Rc (ruthenocenyl) or Oc (osmocenyl), R is 11, alkyl or aryl and Z1 and Z2 are H, alkyl, aryl or substituted alkyl, ferrocenyl, the enol forms of the beta-diketones and metal complexes of the beta-diketones of the general formula M(beta-diketonato)A<1>, M(beta-diketonato)A<1>A<2>, M(beta-diketonato)A<1>B<1>B<2>, M(beta-diketonato)B<1>B<2 >and M(beta-diketonato)B<1>B<2>B<3>B<4>. M is Rh or Ir, A<1 >and A<2 >are cyclic dienes having 6-8 carbons, or linear alkenes having 2-7 carbons. B<1>, B<2>, B<3 >and B<4 >are selected from CO, P(R<1>R<2>R<3>), P(OR<1>)(OR<2>)(OR<3>), R<4 >and X in which R<1>, R<2>, R<3 >and R<4 >are independently alkyl, phenyl or ferrocenyl, and X is a halide or a pseudohalide.
Patent IL-164332-A0 (IL)
Title: Compositions comprising dietary fat complexer and methods for their use
IPC: A21D2/18
Filed: 2003-07-29
Abstract: This invention relates to fat containing consumable food products comprising a-cyclodextrin. The food products have reduced levels of bioavailable fat but have substantially the same fat, cholestrerol and caloric content as a like food without a-cyclodextrin. The invention also relates to methods for reducing the bioavailability of fats in fat containing food products without reducing caloric intake as determined by bomb calorimetry and to methods for increasing high density lipoproteins in a subject and reducing or controlling weight by administering the food products of this invention.
Patent IL-183719-A0 (IL)
Title: Method and apparatus for providing configurable layers and protocols in a communication system
IPC: H04L29/06
Filed: 2007-06-06
Abstract: The layers and protocols of an air interface layering architecture are designed to be modular and can be modified and upgraded to support new features, perform complex tasks, and implement additional functionality. Prior to commencement of data communication between a first entity (e.g., an access terminal) and a second entity (e.g., a radio network), a set of layers and/or protocols is selected for negotiation. For each selected layer and protocol (i.e., each attribute), a list of attribute values considered acceptable to the first entity is determined. The selected attributes and their associated attribute values are sent from the first entity and, in response, a list of processed attributes and their associated lists of processed attribute values arc received. Each list of processed attribute values includes attribute values considered acceptable to the second entity. The layers and protocols in the first entity are then configured in accordance with the received list of processed attributes and their associated processed attribute values. Other features related to configurable layers and protocols are also provided.
Patent IL-192785-A0 (IL)
Title: Cutting tool with protrusions, and methods of use thereof
Filed: 2008-07-13
Abstract: A cutting element adapted for removing a chip from a surface of a workpiece has at least one cutting edge defined by an intersection line between a rake and a relief surface and is formed with one or more workpiece deforming protrusions. At least a portion of the protrusions is spaced from the cutting edge such this portion protrudes, along a plane perpendicular to the relief surface and passing through the cutting edge, in a direction transverse to the relief surface beyond the cutting edge. At least the projecting portion of at least one of the protrusions is constructed so as to deform the workpiece before its contact with the cutting edge.
Patent IL-198610-A0 (IL)
Title: Chemical compounds
Filed: 2009-05-06
Abstract: Phosphoramidate derivatives of nucleoside compounds of formula I derived from bases such as adenine and guanine have enhanced therapeutic potency, in particular, enhanced potency with respect to the prophylaxis or treatment of a viral infection such as hepatitis C virus. The glycoside moiety of the nucleoside compound is suitably substituted at the ²-2' position with methyl and the phosphoramidate group suitably comprises 1-naphthyI linked by -O- to the P atom.
Patent RO-128830-A0 (RO)
Title: Fuel inhibitor additives for reducing sensitivity in gasoline and gasolines obtained by using the same
Inventor: CRISTEA TIBERIU
IPC: C10L1/10
Filed: 2012-11-12
Abstract: The invention relates to a fuel inhibitor additive and the use thereof in gasoline compositions. According to the invention, the additive comprises a nitroderivative chosen from 3-nitrotoluene or 4-nitrotoluene, possibly in admixture with an aromatic and/or aliphatic solvent in a ratio of 10 : 1, and in a ratio of 8 : 1, with a polyalkoxyalkane chosen from 1.1-dihydroxyethan and 2.2-diethoxypropane, respectively, in a ratio of 15 : 1 with an oxygenated fuel inhibitor compound chosen from aliphatic alcohols CHO and alkylalkylethers CHOCHas such or in mixture, in a ratio of 30 : 1 with an aromatic amine chosen from N-methylaniline, 3-toluidine and 4-toluidine with a fuel inhibitor organometallic compound of ferrocene type and an oxygenated compound of the methyl tert butyl ether type, the ratios being expressed by volume. As claimed by the invention, the additive is used in gasoline formulations with octane numbers RON of 94...98 and MON of 83...87 having a ratio thereof of 0.8...1.5.
Patent RO-128975-A0 (RO)
Title: Multifunction therapeutical device and process for making the same
Inventor: PROIETTI ORZELLA GUIDO
IPC: A61N1/02
Filed: 2013-04-08
Abstract: The invention relates to a multifunction therapeutical device to be used in modern alternative therapeutical techniques, such as magneto-therapy and bio-stimulation, for treating various diseases of circulatory, muscular and nervous systems and to a process for making the same. According to the invention, the device has the shape of a circular bracelet (1) made of a plastic strip, in the middle of which there is mounted a bio-stimulating means consisting of a core (2) made of conductive silver charged with carbon nanotubes; the circular bracelet (1) is provided with an electrode (3) making the contact with the skin, having a plurality of silver filaments (4) throughout its length, and steel rods (6) mounted at the ends, for fixing it onto the wrist. The claimed process for making the device consists in cutting the plastic strip at the desired length, printing the silver filaments (4) and core (2), printing an insulating background, printing the electrode (3), cutting the ends with a laser apparatus, applying a transparent silicone sheath (5) for sealing and attaching the rods (6).
Patent RO-130227-A0 (RO)
Title: Tyre external and internal systems
Inventor: WINZINGER EDUARD
IPC: B60C27/00
Filed: 2014-12-02
Abstract: The invention relates to an external system and an internal system of a tyre acting, on the one hand, from the exterior upon a pressurized rubber tyre with a view to increasing the motor vehicle breaking power and, on the other hand, from the interior of the tyre, with a view to limiting up to zero the elastic deformations caused by the useful loads acting upon the tyre, while running. According to the invention, the system consists of two systems, an external one and an internal one, the external system consisting of a system of sprinklers () mounted in front of the motor vehicle wheels, which, in case of sudden braking or change of direction, spray a liquid or an anti-skid foam which adheres to the road surface and to the tyres, preventing the wheels from blocking and the motor vehicle from skidding and shortening, as much as possible, the braking distance, while the internal system meant to stiffen the running surface of the tyre comprises several metal elements () having outside the shape and curvature radius of the interior of a rubber tyre () and provided with a reinforcing and joining system (), respectively, to be mounted at the internal part of a tyre, aiming at reducing the elastic deformation () during running under the action of a useful load () and thereby reducing the surface of contact with the ground while running, as well as the internal and external friction forces, to make the road resistance and speed easier and to lead to the reduction of fuel consumption required for the motor vehicle operation.
Patent RO-133205-A0 (RO)
Title: Stand and method for rheological testing of guitar structures
Inventor: STANCIU MARIANA-DOMNICA
IPC: G01N25/16
Filed: 2018-09-27
Abstract: The invention relates to a stand and a method for rheological testing of the guitar structures. According to the invention, the stand comprises a testing cabin (A) inside of which there are: a device (B) for fixing the structure (1) to be tested, some longitudinal guides (2) with the role of providing the smoothness of some clamping elements, some cross guides (3) with the role of adjusting the clamping elements depending on the sizes of the tested structure, a cross guide (4) for fixing a measuring equipment, an apparatus (C) for humidification of air inside the testing cabin (A), some humidity and temperature sensors (D) for monitoring the testing environment, a hygrometer (E) placed close to the tested structure, a data acquisition board and screens for viewing the recordings (F) in real time and a computer (G) for processing and interpreting the results. The claimed method comprises the stages of acclimatizing the testing pieces, measuring the wood humidity, weighing the structure before testing, measuring the relative position of the checking points, supplying electric current to the electrically-actuated components, calibrating the electronic system, fixing the displacement transducers on the tested guitar, tuning the guitar by tensioning the strings to the frequency specific to free strings, recording the displacements/deformations of the tested structure and the air relative humidity variation, processing the results acquired during testing by means of dedicated software and representing graphically the variation curves.
Patent RO-134427-A0 (RO)
Title: Fodder recipe including a mixture of antioxidant for broiler chickens (1-28 days) grown in high thermal stress
Inventor: CRISTE RODICA DIANA
IPC: A23K50/70
Filed: 2019-09-11
Abstract: The invention relates to a fodder composition for broiler chickens of 1-28 days exposed to high ambient temperatures. According to the invention, the composition consists of 1% powder from the creeping woodsorrel (Oxalis corniculata) whole plant, 1% vitamin-mineral premix containing 0.00002% chromium in the form of chromium picolinate, as well as a conventional fodder mixture based on corn, wheat, corn gluten, soy grit, vegetable oil, monocalcium phosphate, calcium carbonate, salt, methionine, lysine and choline, the composition being structured for two phases: starter phase (1-14 days) and growth phase (14-28 days), respectively, having a raw protein content of 23.35 and 23.41%, respectively, an oxidizing capacity of 44.79 and 44.407 mM ascorbic acid equivalent, respectively and 47.434 and 47.017 mM, vitamin E equivalent, respectively.
Patent RO-134613-A0 (RO)
Title: Dental impression guide and method of use
Inventor: COJOCARIU ANDREEA CODRUŢA
IPC: A61C9/00
Filed: 2020-08-19
Abstract: The invention relates to a dental impression device meant for carrying out fixed prosthetic restorations and to a method of using the same. According to the invention, the device consists of a body (G) having the shape of a cover of a patient's prepared teeth, which has inside one or more cavities (1, 2, 3 ...) corresponding to the number and shape of the prepared dental abutments, on which the fixed prosthetic work is made, on the outside the covering segments have a taper shape and they are joined to one another by bridges of continuity, which provide compliance with the configuration of the dental arch on which the restoration is performed, and also a height "h" of the body (G ), adapted to the average height of the abutments. The method of use, as claimed by the invention, consists in making a preliminary positioning of the impression device on the prepared prosthetic field of a patient, then performing a conventional impression with a body (G) of the impression device incorporated in the plaster impression material, injecting liquid silicone into the impression device having the body (G) incorporated in the impression-tray with plaster material, previously taken, the final impression and the use of the final impression to obtain a fixed prosthetic restoration.
Patent AP-2000001993-A0 (AP)
Title: Phthalazine derivatives phosphodiesterase 4 inhibitors.
Inventor: NAPOLETANO MAURO
IPC: C07D237/32
Filed: 1999-07-13
Abstract: Compounds of formula (i), wherein is a single or double bond; z is nh, methylene, a (c2-c6)alkylene chain optionally branched and/or unsaturated and/or interrupted by a (c5-c7)cycloalkyl residue; a is phenyl or heterocycle optionally substituted by one or more substituent(s)selected among oxo, intro, carboxy groups and halogen atoms, or a cor4 group wherein r4 is hydroxy, (c1-c6)-alkoxy, amino optionally substituted by one or two (c1-c6)alkyl group(s)or by hydroxy; r is a (c1-c6)alkyl or polyfluoro(c1-c6)alkyl group; r1 is absent when is a double bond or, when is a single bond, is (a)hydrogen; (b)(c1-c6)alkyl optionally substituted by aryl, by heterocycle or by a cor5 group wherein r5 is hydroxy, (c1-c4)alkoxy or hydroxamino; (c)-cor6 wherein r6 is hydrogen, aryl, aryl-(c1c6)alkyl, amino optionally alkylated or monohydroxylated, hydroxy, (c1-c4)alkoxy, carboxy, (c1-c4)alkoxycarbonyl, formula (i), or (c1-c4)alkyl optionally substituted by heterocycle; (d)(c1-c4)-alkylsulfonyl; r2 represents two hydrogen atoms or a group =0 when is a single bond or when is a double bond, r2 is hydrogen, cyano, (c1-c4)alkoxycarbonyl, amido, optionally substituted aryl or heterocycle, (c1-c8)alkyl, (c2-c8)alkenyl or (c2-c8)alkynyl optionally branched and/or substituted by aryl or heterocycle; aryloxy, heterocyclyloxy, aryl-(c1-c4)alkoxy, heterocyclyl-(c1-c4)alkoxy, amino substituted by one or two (c1-c4)-alkyl group(s), arylamino, heterocyclylamino, aryl(c1-c4)alkylamino, heterocyclyl-(c1-c4)-alkylamino; r3 is hydrogen, or a (c1-c8)alkyl, (c2-c8)alkenyl or (c2-c8)alkynyl group optionally substituted by hydroxy, oxo, aryl or heterocycle, and optionally interrupted by one or more heteroatom(s)or heterogroup(s); the n o derivatives of the compounew of formula (i)and the pharmaceutically acceptable salts thereof are pde 4 inhibitors.
Patent LU-79119-A1 (LU)
Inventor: SCHWEIZER E
IPC: B42F17/00
Filed: 1978-02-23
Abstract: A storage device for storing card-like objects, for example photographs. The device is in the form of a cassette like container in which the objects are stacked upright in a rear section comprising the base, lower parts of each side wall and the rear wall of the cassette. A first section of the cassette is pivoted about the front edge of the base and comprises at least part of the top, the front wall and upper parts of the side walls complementary with the side wall lower parts. In the open condition of the cassette photographs can readily be turned forward one by one to stack face downwards on the front section. A plurality of such cassettes may be pivotally supported in a rectangular frame, one behind the other, so that the contents of each cassette can be readily inspected in turn.
Patent MA-27633-A1 (MA)
Title: Nouveau procede de synthese de l'acide (2s)-indoline -2-carboxylique, et application a la synthese du perindopril.
Inventor: SOUVIE JEAN-CLAUDE
IPC: C07D209/42
Filed: 2005-09-19
Abstract: NOUVEAU PROCEDE DE SYNTHESE DE L'ACIDE (2S)-INDOLINE-2-CARBOXYLIQUE, ET APPLICATION A LA SYNTHESE DU PERINDOPRIL Procédé de synthèse de l'acide (2S) indoline 2-carboxylique de formule (I): Application à la synthèse du perindopril et de ses sels phannaceutiquement acceptables.
Patent MA-20150303-A1 (MA)
Title: Conditionnement d'eau pour usage pharmaceutique (voie enterale)
Inventor: ALI NYAZI
IPC: B65D75/48
Filed: 2014-02-10
Abstract: Notre invention consiste à conditionner une cau pour usage pharmaceutique (voie enterale = a travers la bouche) dans des enceintes en plastique « sachets ou flacons » faites de matière adéquate et facile à être utilisé par le citoyen. Ceci, dans le but de faciliter la tâche pour le malade à préparer son sirop au moment de l’utilisation.
Patent MA-38465-A1 (MA)
Title: Forme posologique de l'antagoniste du récepteur de la progestérone
Inventor: SCHÜTT BARBARA
IPC: A61P15/00
Filed: 2014-04-09
Abstract: La présente invention concerne une composition pharmaceutique comprenant un antagoniste du récepteur de la progestérone à savoir (11 ß,17ß)-17-hydroxy-11-[4-(méthylsulphonyl)phényle]-17-(pentafluoroéthyl)estra-4,9-dien-3-un dont la posologie est de 0,5 à 5 mg environ et plus particulièrement 2 mg. De plus, l'invention concerne l'utilisation d'une nouvelle composition pharmaceutique destinée au traitement et à la prophylaxie des maladies gynécologiques comme les fibroïdes utérins (myomes, fibrome utérin), l'endométriose ou les saignements menstruels excessifs et un procédé permettant d'obtenir cette composition et une forme posologique orale.
Patent UY-24865-A1 (UY)
Title: Derivados del 8-sustituido -1,3,8-triazo-spiro (4.5) decan-4- ona
Inventor: ADAM GEO
IPC: A61P25/28
Filed: 1998-01-29
Abstract: Compuestos de fórmula general (I), representada en la figura 1, y sales de adición de los mismos, en particular derivados de la 8-sustituida-1,3,8-triazospiro[4.5]-4-ona,donde: R1 y R2 son independientemente el uno del otro, hidrógeno, alquilo, alcoxi o halógeno; R3 es fenilo, alquilo opcionalmente sustituido, CF3, alcoxi o halógeno; A es un anillo saturado de 4 a 7 miembros; R5 y R6 son independientemente el uno del otro, hidrógeno, fenilo, alquilo o di-alquilo o juntos pueden formar un anillo fenilo, y R5 y uno de R1 y R2 pueden formar juntos un anillo saturado o no saturado de 6 miembros; cn la condición que dicho compuesto de fórmula general (I) no sea 8-(8-metoxi-1,2,3,4-tetrahidro-2-naftalenil)-1-fenil-1,3,8-triaza-spiro[4,5]decan-4-ona. Ejemplos no limitantes de compuestos de fórmula general (I): 8-(5,8-dicloro-1,2,3,4-tetrahidro-naftil-2)-3-metil-1-fenil-1,3,8-triaza-spiro[4,5]decan-4-ona; éster metílico de ácido [8-(5,8-dicloro-1,2,3,4-tetrahidro-naftil-2)-4-oxo-1-fenil-1,3,8-triaza-spiro[4,5]dec-3-il] acético. Se incluyen medicamentos que los contienen para el tratamiento de enfermedades relacionadas con el receptor de orfaniana FQ(OFQ), que incluye trastornos siquiátricos, neurológicos y fisiológicos; como por ejemplo trastornos de ansiedad y Alzheimer.
Patent UY-26164-A1 (UY)
Title: Profarmácos mutuos de amlodipino y atorvastatina
Inventor: CHANG GEORGE
Filed: 2000-05-25
Abstract: Profármacos mutuos de amlodipino y atorvastatina y a las composiciones farmacéuticas de los mismos. Procedimientos para tratar la angina de pecho, la aterosclerosis y la hipertensión y la hiperlipidemia en un mamífero mediante el uso de estos profármacos y composiciones. Procedimientos para tratar el riesgo cardíaco en un mamífero, incluyendo humanos, que presenta síntomas de riesgo cardíaco mediante la administración de estos profármacos y composiciones.
Patent UY-27411-A1 (UY)
Title: 1-alquil o 1-cicloalquil-triazolo (4, 3-a) quinazolin-5-onas como inhibidoras de fosfodiesterasa.
Inventor: BERNARD GAUDILLIERE
Filed: 2002-08-09
Abstract: La invención se relaciona con compuestos de la fórmula (I) en donde R1, R2 y R3 son lo definido en la memoria descriptiva, su uso como medicamentos, el proceso para su preparación y su uso para el tratamiento de patologías en las cuales la terapia con un inhibidor de PDE4 es relevante.
Patent UY-28416-A1 (UY)
Title: Motor de combustion rapida a nafta
Inventor: RUCHI MIGUEL HUGO
Filed: 2004-07-15
Abstract: Es un motor con una nueva combustión que es rápida, funciona utilizando cualquier nafta, obteniendo mayor eficiencia mediante una combustión, que en su proceso es rápida, controlada y completa. Ajustado al posicionamiento óptimo para la propulsión. Se ubica dentro de los motores de combustión interna de movimiento alternativo de encendido por compresión.