Patent SG-11201907804Q-A (SG)
Title: Pharmaceutical composition comprising selexipag
Inventor: HELLERBRAND KLAUS
IPC: A61P17/02
Filed: 2018-03-07
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 13 September 2018 (13.09.2018) WIP0 I PCT oimiolollm °noI0 OilIIIIIOHIIIII010m Oila° oimIE (10) International Publication Number WO 2018/162527 Al (51) International Patent Classification: A61K 47/10 (2017.01) A61P 17/02 (2006.01) A61K 9/19 (2006.01) A61P 9/12 (2006.01) A61K 31/4965 (2006.01) (21) International Application Number: PCT/EP2018/055551 (22) International Filing Date: 07 March 2018 (07.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/EP2017/055406 08 March 2017 (08.03.2017) EP (71) Applicant: ACTELION PHARMACEUTICALS LTD [CH/CH]; Gewerbestrasse 16, 4123 Allschwil (CH). (72) Inventors: HELLERBRAND, Klaus; c/o ProJect Phar- maceutics GmbH, Fraunhoferstrasse 22, 82152 Martinsried (DE). SCHLICKER-SPAIN, Alexandra; c/o Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123 Allschwil (CH). (74) Agent: SCHAGER, Frank; Gewerbestrasse 16, 4123 Allschwil (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) Published: with international search report (Art. 21(3)) 11 N N (54) Title: PHARMACEUTICAL COMPOSITION COMPRISING SELEXIPAG 1 1 ei (57) : The invention relates to aqueous pharmaceutical compositions comprising the compound 2-{44N-(5,6- diphenylpyrazin-2-y1)-N-isopropylamino]butyloxy} -N-(methylsulfonyl) acetamide; glycine; polysorbate 20; and an aqueous phosphate buffer, wherein the relative amounts are as described in the description, wherein the pH of said pharmaceutical composition is between wc ' s about 7 and 8; to lyophilized pharmaceutical compositions prepared from said aqueous compositions, and to reconstituted aqueous © compositions thereof which are suitable for i.v. administration. The invention further relates to processes for the preparation of said f'1 compositions, and to their use for the treatment of diseases and disorders which are related to IP receptor.