Patent SG-11201807489P-A (SG)
Title: Cells expressing multiple chimeric antigen receptor (car) molecules and uses therefore
Inventor: DRANOFF GLENN
IPC: C12N5/0783
Filed: 2017-03-03
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111101111011101010111110101111101110101111111111101101111101111101111011111 International Bureau .. .... ..Yejd .... ...,,, (10) International Publication Number (43) International Publication Date WO 2017/149515 Al 8 September 2017 (08.09.2017) WIP0 I PCT (51) International Patent Classification: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, C07K 14/725 (2006.01) Cl2N 5/0783 (2010.01) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, C07K 16/30 (2006.01) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (21) International Application Number: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, PCT/IB2017/051267 RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (22) International Filing Date: TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, 3 March 2017 (03.03.2017) ZA, ZM, ZW. (25) Filing Language: English (8 4 ) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (26) Publication Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (30) Priority Data: TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 62/303,466 4 March 2016 (04.03.2016) US TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (71) Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, 4056 Basel (CH). THE TRUSTEES OF THE UNIVER- SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, SITY OF PENNSYLVANIA [US/US]; 3160 Chestnut GW, KM, ML, MR, NE, SN, TD, TG). Street, Suite 200, Philadelphia, Pennsylvania 19104 (US). Declarations under Rule 4.17: (72) Inventor: DRANOFF, Glenn; c/o Novartis Institutes for as to applicant's entitlement to apply for and be granted a Research, Inc., 250 Massachusetts Avenue, Cambridge, patent (Rule 4.17(H)) _ Massachusetts 02139 (US). (74) Agent: NOVARTIS AG; Lichtstrasse 35, 4056 Basel Published: = (CH). — with international search report (Art. 21(3)) = (81) Designated States (unless otherwise indicated, for every — before the expiration of the time limit for amending the kind of national protection available): AE, AG, AL, AM, claims and to be republished in the event of receipt of AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, amendments (Rule 48.2(h)) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, = (54) Title: CELLS EXPRESSING MULTIPLE CHIMERIC ANTIGEN RECEPTOR (CAR) MOLECULES AND USES THERE- = _ FORE = — Figure 1 = = Anti-CD19 Anti-EGFRvill 1 scFv scFv = , = 1 I I = — » co 0 0 t$ , 03 Tr 1 : 0 • %- ii o' s i_ ci n C4 Ia. III co 13 CS 0 , 0:1 T r Ca x- fi o ha. 11 Anti-CD19 Anti-Mesothelin scFv scFv kr) 1-1 i i kr) r cr, ii- 11 Bi co CI CS 0 . co .11:1 r ti orsa. i_ a CNI 0. co CI CS 0 . co .1. CO r ti (...) NJ\" i_ Ir ---- 11 N (57) : The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein by administration of a cell comprising a chimeric antigen receptor that binds a B-Cell antigen and a chimeric an - 0 tigen receptor which binds a tumor antigen.