Patent RU-2513086-C2 (RU)
Inventor: GALLEJ GUIDO
IPC: A61P25/00
Filed: 2009-07-15
Granted: 2014-04-20
Abstract: FIELD: chemistry. 
     SUBSTANCE: invention relates to application of compounds of formula   I, where R 1  represents hydrogen atom, C 1-7 -alkyl, C 1-7 -alkoxy, C 1-7 -alkyl, substituted with halogen atom, C 1-7 -alkoxy, substituted with halogen atom, halogen atom, cyano, nitro, hydroxy, C(O)O-C 1-7 -alkyl, S(O) 2 -C 1-7 -alkyl, C(O)OCH 2 -phenyl, OCH 2 -phenyl, tetrazol-1-yl, phenyl, possibly substituted with halogen atom, or represents phenyloxy, possibly substituted with halogen atom, or represents benzyl, possibly substituted with halogen atom, or represents benzyloxy, possibly substituted with halogen atom; in case, when n>1, R 1  substituents can be similar or different; X represents -O-(CH 2 ) 2 -, -O-CHR"-CH 2 -, -O-CH 2 -CHR', -O-CR" 2 -CH 2 -, -(CH 2 ) 2 -CHR'-, -CHR'-(CH 2 ) 2 -, -CR" 2 -(CH 2 ) 2 -, -CH 2 -CHR'-CH 2 -, -CH 2 -CR" 2 -CH 2 -, -CHR"-O-CH 2 -, -CR" 2 -O-CH 2 -, -CF 2 (CH 2 ) 2 -, -CR" 2 -CH 2 -, -SiR" 2 -(CH 2 ) 2 -, -S-(CH 2 ) 2 -, -S(O) 2 -(CH 2 ) 2 -, -(CH 2 ) 4 -, -CH 2 -O-(CH 2 ) 2 -, formula   (a) or   (b), where m has value 0, 1, 2 or 3; R' represents C 1-7 -alkyl, C 1-7 -alkoxy or C 1-7 -alkyl, substituted with halogen atom; R" represents C 1-7 -alkyl or C 1-7 -alkyl, substituted with halogen atom; R 2  represents hydrogen atom or C 1-7 -alkyl; Y represents phenyl, naphthyl, C 3-6 -cycloalkyl or pyridin-2- or 3-yl, pyrimidin-2-yl or quinolin-6 or 7-yl; n has value 1, 2 or 3; or pharmaceutically acceptable salt of acid attachment in manufacturing medication for treatment anxiety disorders, bipolar disorder, stress-induced disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson disease, neurodegenerative disorders, Alzheimer's disease, epilepsy and migraine. Invention also relates to compounds of formula I, where R 1  represents hydrogen atom, C 1-7 -alkyl, C 1-7 -alkoxy, C 1-7 -alkyl, substituted with halogen atom, C 1-7 -alkoxy, substituted with halogen atom, halogen atom, cyano, nitro, hydroxy, C(O)O-C 1-7 -alkyl, S(O) 2 -C 1-7 -alkyl, C(O)OCH 2 -phenyl, OCH 2 phenyl, tetrazol-1-yl, phenyl, possibly substituted with halogen atom, or represents phenyloxy, possibly substituted with halogen atom, or represents benzyl, possibly substituted with halogen atom, or represents benzyloxy, possibly substituted with halogen atom; in case when n>1, R 1  substituents can be similar or different; X represents -(CH 2 ) 2 -CHR', -CHR'-(CH 2 ) 2 -, -CR" 2 -(CH 2 ) 2 -, -CH 2 -CHR'-CH 2 -, -CH 2 -CR" 2 -CH 2 -, -CF 2 (CH 2 ) 2 -, formula (a), where m has value 0, 1, 2 or 3; R' represents C 1-7 -alkyl, C 1-7 -alkoxy or C 1-7 -alkyl, substituted with halogen atom; R" represents C 1-7 -alkyl or C 1-7 -alkyl, substituted with halogen atom; R 2  represents hydrogen atom or C 1-7 -alkyl; Y represents phenyl, naphthyl, C 3-6 -cycloalkyl or pyridin-2- or 3-yl, pyrimidin-2-yl or chinolin-6 or 7-yl; n has value 1, 2 or 3; or pharmaceutically acceptable salt of acid attachment. Also claimed are methods of obtaining formula (I) compounds. 
     EFFECT: 4,5-dihydro-oxazol-2-ylamine derivatives for treatment of diseases, associated with biological function of receptors, associated with trace amines. 
     22 cl, 1 tbl, 176 ex