baber/WOPTO huggingface dataset:
Patent CA-2413981-A1 (CA)
Title: Method for providing natural therapeutic agents with high therapeutic index
Inventor: ESCARY JEAN-LOUIS
IPC: G01N33/68
Filed: 2002-12-11
Abstract: A method for providing new therapeutic agent(s) that comprises the following steps:   a) selecting at least one polypeptide encoded by a natural allelic variant of one preselected gene with therapeutic potential and/or of at least one related gene thereof;   b) determining the therapeutic index of the polypeptide(s) selected in step a); and c) retaining as therapeutic agent(s), the polypeptide(s) selected in step a) whose therapeutic index, as determined in step b), is higher than a therapeutic index of reference.
Patent CA-2414355-A1 (CA)
Title: Amphipathic linear peptides and compositions containing same
Inventor: TEMSAMANI JAMAL
IPC: A61K47/48
Filed: 2001-07-03
Abstract: The invention concerns peptides containing or consisting of an antibiotic peptide by (i) modification of cysteine residues so that said peptide is devoid of disulphide bond, (ii) substitution of 1 to 18 and preferably of 1 to 5 amino acids, and/or permutation of at least a pair of amino acids, said substitutions and/or permutations being such that said peptide has an amphipathic character. The invention also concerns a compound formed by at least one of said peptide directly or indirectly bound to at least an active substance.
Patent CA-2416060-A1 (CA)
Inventor: LIPPE MICHEL
IPC: A47K3/30
Filed: 2003-01-10
Abstract: The shower structure comprises a base for containing water, two panels and a two-part elongated joint. The base comprises a doorstep, a base edge and a bottom. The base edge has an inner portion lower than upper surface of the doorstep. Each panel has a first panel edge provided with an inner portion for contact with the inner portion of the base edge for fitting the base and the panel in a watertight manner, a second panel edge also provided with an inner portion. The joint includes an outer part having, along its length, two distal joint edges. Each joint edge is adapted for connection to the inner portion of the second panel edge for fitting the panel and the outer part of the joint together. An inner part of the joint is connected to the outer part for sealing the base and panels together in a watertight manner.
Patent CA-2417352-A1 (CA)
Inventor: GAMLEN CAROL
IPC: H01H59/00
Filed: 2001-08-04
Abstract: A microelectromechanical structure having a ceramic substrate formed from low temperature co-fired ceramic sheets. A low loss photodefinable dielectric planarizing layer is formed over one surface of the ceramic substrate. This layer can be a sacrificial layer or a subsequent sacrificial layer added. A  photodefined conductor is printed over the low loss dielectric planarizing layer and formed with the sacrificial layer into a structural circuit component. A switch is formed with a biasing actuator and deflectable member formed over the biasing actuator and moveable into open and closed circuit positions.
Patent CA-2418009-A1 (CA)
Title: Normal travel securing device for automobile equipped with accelerator mal-operation preventer
Inventor: WATANABE MASAEI
IPC: F02D11/02
Filed: 2001-08-07
Abstract: When an automobile is stopping or traveling at a speed lower than a predetermined speed, an accelerator interlocking member (26) and an accelerator function follow-up member (28) are magnetically coupled, and accelerator mal-operation is prevented by releasing them from magnetic coupling, while when a car speed during normal travel which is higher than the predetermined value is detected, a normal travel securing device (100) locks the accelerator interlocking member (26) and accelerator function follow-up member (28), which are magnetically coupled, so as to couple them mechanically, thus integrally coupling the accelerator interlocking member and accelerator function follow-up member to prevent release from magnetic coupling during normal travel; thus overtaking and hill-climbing travel can be reliably effected.
Patent CA-2418585-A1 (CA)
Inventor: BAKER SCOTT
IPC: B60B7/00
Filed: 2003-02-10
Abstract: A mounting assembly for a movable decorative member to be mounted on a rotatable wheel hub including a weighted mass having a mounting portion carrying a ball bearing disposed on a boss provided on a securement cap stud. The stud includes a threaded shaft engageable with the coupler or hub per se. The coupler is a flanged base or a base having radially projecting legs wherein either the flanged base or the radial legs are detachably connected with the hub. The bearing has a turning axis and the weighted mass decorative member is eccentric or off-center of the turning axis so that the decorative member downwardly depends from the beating in a static appearing condition. A fixed, decorative member may be included which is secured to the hub so as to rotate therewith while the movable decorative member appears stationary.
Patent CA-2419133-A1 (CA)
Inventor: CLINTON GAIL M
IPC: A61K38/17
Filed: 2001-08-14
Abstract: An alternative HER-2/neu product, herstatin, consists of subdomains I and II  from the ectodomain of p185HER-2 and a unique 79 amino acid C-terminus encod ed by intron 8. Recombinant herstatin added to cells was found to bind and inhibit p185HER-2. The effects of ectopic expression of herstatin in combination with either p185HER-2 or with its homolog, the EGF receptor, was  studied. Cotransfection of herstatin with HER-2 inhibited p185HER-2 levels a nd caused an approximate 8-fold reduction in p185 tyrosine phosphorylation. Inhibition of p185HER-2 tyrosine phosphorylation corresponded to a dramatic decline in colony formation by cells that coexpressed p185HER-2 and herstati n. Herstatin also interfered with EGF activation of the EGF receptor. For both p185HER-2 and the EGF receptor, the extent of inhibition was affected by the  expression levels of herstatin relative to the receptor. Herstatin is an autoinhibitor of p185HER-2 and expands it's inhibitory activity to another member of the group I family of receptor tyrosine kinases, the EGF receptor.
Patent CA-2419585-A1 (CA)
Inventor: FRITZ EBERHARD
IPC: G01N21/55
Filed: 2001-10-02
Abstract: La présente invention concerne un procédé destiné à être utilisé dans une procédure de vérification d'un joint de soudure reliant deux parties métalliques, ledit procédé comprenant les étapes suivantes: on utilise deux faisceaux laser, on dirige le premier faisceau laser sur un premier endroit prédéterminé situé sur la première partie métallique et on dirige le deuxième faisceau laser sur un deuxième endroit prédéterminé situé sur la deuxième partie métallique, puis on détecte la lumière des faisceaux laser réfléchie le long du joint de soudure. Cette invention concerne également un appareil permettant de vérifier le joint de soudure effectué par faisceaux laser qui relie un contenant ou un tube métallique et un bouchon métallique, ledit appareil comprenant: deux dispositifs émettant un faisceau laser ou un dispositif émettant un faisceau laser d'exploration, un moyen de positionnement du contenant ou du tube et du bouchon dans une position telle que le premier faisceau laser est dirigé sur un premier endroit prédéterminé sur le contenant ou le tube et que le deuxième faisceau laser est dirigé sur un deuxième endroit prédéterminé sur le contenant ou le tube, ou dans une position telle que les faisceaux laser d'exploration balaient les premier et deuxième endroits prédéterminés, et facultativement un moyen d'arrêt, un moyen servant à déplacer le contenant ou le tube et le bouchon de manière à permettre d'effectuer le balayage du ou des faisceaux laser le long du joint de soudure et un détecteur servant à détecter la lumière réfléchie du ou des faisceaux laser le long du joint de soudure.
Patent CA-2425926-A1 (CA)
Inventor: VAINIO JANNE
IPC: G10L19/005
Filed: 2001-10-17
Abstract: A speech coding method and device for encoding and decoding an input signal, wherein the higher frequency components of the synthesized speech are achieved by high-pass filtering and coloring an artificial signal. The processed artificial signal is scaled by a first scaling factor during the active speech periods of the input signal and a second scaling factor during the non-active speech periods, wherein the first scaling factor is characteristic of the higher frequency band of the input signal and the second scaling factor is characteristic of the lower frequency band of the input signal. In particular, the second scaling factor is estimated based on the lower frequency components of the synthesized speech and the coloring of the artificial signal is based on the linear predictive coding coefficients characteristic of the lower frequency of the input signal.
Patent CA-2428005-A1 (CA)
Inventor: JUGENHEIMER KRISTIN A
IPC: A61B17/08
Filed: 2002-06-26
Abstract: A system and method for delivering a sugical clip to a surgical site within a patient's body to compress body tissue is disclosed. In one embodiment for the system of the present invention, the system includes an endoscopis device that has an endoscope cap disposed on a distal end of the endoscopic device. A  surgical clip is removably disposed on an outside surface of the endoscope cap. A deployment device is associated with the surgical clip for deploying the surgical clip (110) from the endoscope cap to the body tissue that is to be compressed. The surgical clip can be a deformable clip that is deployed in a non deformed configuration, and is then deformed so as to apply compression on selected tissue. The surgical clip can be a multi legged clip, having a plurality of legs that can be locked in a closed position to apply compression to body tissue.
Patent CA-2428971-A1 (CA)
Title: Conjugues d'un agent therapeutique et d'un porteur peptidique
Inventor: PICCARIELLO THOMAS
IPC: A61K31/52
Filed: 2001-11-14
Abstract: L'invention concerne une composition comprenant un polypeptide et du benzatropine mésylate relié par covalence au polypeptide. La présente invention concerne également un procédé d'administration de benzatropine mésylate à un patient, consistant à administrer au patient une composition comprenant un polypeptide et du benzatropine mésylate relié par covalence au polypeptide. En outre, cette invention concerne un procédé permettant de protéger le benzatropine mésylate contre la dégradation, qui consiste à relier le benzatropine mésylate par covalence à un polypeptide. L'invention concerne également un procédé de régulation de la libération de benzatropine mésylate d'une composition, consistant à relier par covalence le benzatropine mésylate au polypeptide.
Patent CA-2430846-A1 (CA)
Inventor: MIYACHI HIROYUKI
IPC: A61P9/10
Filed: 2001-12-04
Abstract: L'invention se rapporte à de nouveaux dérivés de l'acide carboxylique substitués qui se lient, en tant que ligands, à un récepteur activé proliférateur de peroxysome (PPAR) de manière à activer ce récepteur et qui de ce fait présentent de puissants effets s'agissant de la réduction des graisses neutres, du cholestérol et de la glycémie. L'invention se rapporte également à un procédé de préparation de ces dérivés. Spécifiquement, l'invention se rapporte à des dérivés d'acide carboxylique substitués représentés par la formule générale (1) ainsi qu'à des sels et hydrates pharmaceutiquement acceptables de ces dérivés, et à un procédé de préparation de ces dérivés, sels ou hydrates.
Patent CA-2432739-A1 (CA)
Inventor: THOMASCO LISA MARIE
IPC: C07D263/20
Filed: 2001-12-14
Abstract: Cette invention concerne de nouveaux composés qui conviennent bien comme sondes de photo-affinité et des procédés faisant intervenir des sondes de photo-affinité à base d'oxazolidinone.
Patent CA-2434051-A1 (CA)
Title: Expandable styrene polymers containing carbon particles
Inventor: GLUECK GUISCARD
IPC: C08K3/04
Filed: 2002-01-11
Abstract: The invention relates to EPS particles that contain graphite particles or carbon black particles and, as expanding agents, 2.2 to 6 wt. % pentane and 1 to 10 wt. % water.
Patent CA-2435551-A1 (CA)
Inventor: FIELDHOUSE DANIEL
IPC: G16B30/00
Filed: 2002-01-25
Abstract: Cette invention se rapporte à une famille de séquences nucléotidiques à hybridation croisée minimale et à des procédés d'utilisation de cette famille, notamment. Une famille spécifique de 1168 24mères est décrite.
Patent CA-2442632-A1 (CA)
Title: Digital video processing method and apparatus thereof
Inventor: SUN XINDING
IPC: H04N7/50
Filed: 2000-02-03
Abstract: A digital video processing method and an apparatus thereof are provided. The method for processing digital images received in the form of compressed video streams comprising the step of determining a region intensity histogram (RIH) based on information on motion compensation of inter frames. The RIH information is obtained based on the motion compensation values of inter frames, and the RIH information is a good indicator of motion information of a video scene. Also, since the RIH information is quite a good indicator of intensity of the video scene, video streams having similar intensities can be effectively searched by searching for similar video scenes based on the RIH information obtained by the digital video processing method.
Patent CA-2443222-A1 (CA)
Title: A process and a plant for the production of portland cement clinker
Inventor: TREMBLAY ANNE
IPC: C04B7/36
Filed: 2002-04-12
Abstract: A process is disclosed for producing cement clinker, comprising the steps of:  a) providing a mixture of ground calcareous materials and ground argillaceous materials; b) heating the mixture of step a) to a temperature sufficient to calcine and fuse the ground materials to form the cement clinker, and thereby producing an exhaust gas containing CO2; c) catalysing the hydration of at least a portion of the CO2 contained in the exhaust gas and producing a solution containing bicarbonate ions and hydrogen ions; and d) adding to the solution obtained in step c) metal ions, and adjusting the pH of the solution to precipitate a carbonate of said metal. Preferably, the metal ions are Ca++  obtained from the dissolution of a material selected from the group consisting of CaCl2, cement kiln dust and sea salts and the carbonate is CaCO3 which is advantageously recycled into the process by adding the CaCO3 to the mixture of step a). A cement plant for performing this process is also disclosed.
Patent CA-2443419-A1 (CA)
Title: Stump grinding wheel and cutting assemblies therefor
Inventor: MONYAK KENNETH
IPC: A01G23/06
Filed: 2002-04-16
Abstract: A stump grinding tool includes a rotary cutting wheel having a pair of side surfaces and an outer peripheral surface. Cutting assemblies are mounted on the cutting wheel, each cutting assembly including first and second pockets disposed on respective side surfaces of the wheel. Each pocket includes a leading through-hole and a trailing through-hole aligned with respective leading end trailing through-holes of the other pocket for receiving a pair of cutting teeth. Each tooth extends through aligned through-holes of the pocket and cutting wheel in mutually opposite directions, wherein cutting elements of the teeth are disposed adjacent respective ones of the side surfaces. Each tooth is fixed by a nut threaded thereon such that each tooth and associated nut functions to clamp both of the first and second pockets against the respective side surfaces of the cutting wheel.
Patent CA-2443666-A1 (CA)
Inventor: CHANG CHAWNSHANG
IPC: C07K14/72
Filed: 2002-04-05
Abstract: Disclosed are compositions and methods for related to signal transduction pathways related to androgen receptor.
Patent CA-2445064-A1 (CA)
Title: Outboard motor equipped with water-cooled engine
Inventor: KURODA TATSUYA
IPC: F01P11/00
Filed: 2003-10-09
Abstract: An outboard motor equipped with a water-cooled engine includes an exhaust manifold cooling water jacket for cooling an exhaust manifold for discharging to the outside exhaust gas from a combustion chamber, the exhaust manifold cooling water jacket being supplied with cooling water from a cooling water pump. A water outlet provided in the highest part of the exhaust manifold cooling water jacket is made to communicate with a water check outlet for confirming the circulation of cooling water due to operation of the cooling water pump. Thus, it is possible to reliably discharge air residing within the exhaust manifold cooling water jacket through the water check outlet. Since the water check outlet is used as an opening for discharging air, it is unnecessary to provide a special air outlet.
Patent CA-2445936-A1 (CA)
Inventor: HUANG CHIN-TIEN
IPC: E06B9/386
Filed: 2003-10-21
Abstract: A window covering having a plurality of panels comprising a head rail and a plurality of panels suspended from the head rail by a securement member and an opening member is provided. Each of the plurality of panels is collapsible and includes a pair of opposed longitudinal regions. A bottom rail may also be provided and suspended from the head rail such that the plurality of panels are located between the head rail and the bottom rail.
Patent CA-2448192-A1 (CA)
Title: Pyrimidine derivatives useful as selective cox-2 inhibitors
Inventor: PAYNE JEREMY JOHN
IPC: A61K31/505
Filed: 2002-05-23
Abstract: The invention provides the compounds of formula (I) in which: R1 is selected from the group consisting of H, C1-6alkyl, C1-2alkyl substituted by one to five fluorine atoms, C3-6alkenyl, C3-10cycloalkylC0-6alkyl, C4-12bridged cycloalkyl, A(CR4R5)n and b(CR4R5)n; R2 is C1-2alkyl substituted by one to five fluorine atoms; R3 is selected from the group consisting of C1-6alkyl, NH2 and R7CONH; R4 and R5 are independently selected from H or C1-6alkyl; A is an unsubstituted 5- or 6-membered heteroaryl or an unsubstituted 6-membered aryl, or a 5- or 6-membered heteroaryl or a 6-membered aryl substituted by o ne or more R6; R6 is selected from the group consisting of halogen, C1-6alkyl, C1- 6alkyl substituted by one or more fluorine atoms, C1-6alkoxy, C1-6alkoxy substituted by one or more F, NH2SO2 and C1-6alkylSO2; B is selected from th e group consisting of Formula (i) and (ii) and where (iv) defines the point of attachment of the ring; R7 is selected from the group consisting of H, C1- 6alkyl, C1-6alkoxy, C1-6alkylOC1-6alkyl, phenyl, HO2CC1-6alkyl, C1-6alkylOCO C1- 6alkyl, C1-6alkylOCO, H2NC1-6alkyl, C1-6alkylOCONHC1-6alkyl and C1- 6alkylCONHC1-6alkyl; and n is 0 to 4. Compounds of formula (I) are potent an d selective inhibitors of COX-2 and are of use in treatment of the pain, fever and inflammation of variety of conditions and diseases.
Patent CA-2448737-A1 (CA)
Title: Viral polymerase inhibitors
Inventor: FAZAL GULREZ
IPC: C07D403/04
Filed: 2002-07-18
Abstract: An isomer, enantiomer, diastereoisomer, or tautomer of a compound, represented by formula (I): wherein R1 is selected from: H, haloalkyl, (C1-6)alkyl, (C2-6)alkenyl, (C3-7)cycloalkyl, (C2-6)alkynyl, (C5-7)cycloalkenyl, 6 or 10-membered aryl, Het all optionally substituted; R2 is selected from (C1-6)alkyl, (C3-7)cycloalkyl, (C6-10)bicycloalkyl, 6- or 10-membered aryl, or Het all optionally substituted; B is N or CR5, wherein R5 is H, halogen, haloalkyl, (C1-6)alkyl, (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; X is N or CR5; D is N or CR5; each of Y1 and Y2 is independently O or S; Z is O, N, or NRz wherein Rz is H, (C1-6)alkyl, (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; R3 and R4 are each independently H, (C1-6)alkyl, first (C3-7)cycloalkyl, 6- or 10-membered aryl, Het (C1-6)alkyl-6- or 10-membered aryl, (C1-6)alkyl-Het; or each R3 and R4 are independently covalently bonded together to form second (C3-7)cycloalkyl, or heterocycle, all optionally substituted; or when Z is N, either R3 or R4 are independently covalently bonded thereto to form a nitrogen-containing heterocycle; R7 is H, (C1-6 alkyl), (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; or R7 is covalently bonded to either of R3 or R4 to form a heterocycle; A is (C1-6) alkyl-CONHR8 wherein R8 is-6- or 10-membered aryl, or Het; or A is a 6- or 10-membered aryl, or Het said aryl or Het being optionally substituted; or a salt or a derivative thereof; such compounds being potent inhibitors of HCV NS5B  polymerase.
Patent CA-2453271-A1 (CA)
Inventor: KAMEN MELVIN E
IPC: B32B27/18
Filed: 2002-07-10
Abstract: The present invention is directed to compositions and methods relating to UV  blocking inks for transparent substrates, which requires UV curing for application onto the substrates.
Patent CA-2453824-A1 (CA)
Title: Dispositif de nettoyage des vitres
Inventor: TIRKKONEN SARI
IPC: A47L1/06
Filed: 2002-07-04
Abstract: Cette invention porte sur un ustensile servant à sécher les surfaces vitrées, lequel ustensile se compose d'une partie cadre (1), d'une partie raclette (2) fixée à la partie cadre, et d'un guide (3) servant à guider l'action de séchage et l'écoulement de l'eau. Dans l'ustensile de séchage de la présente invention, le guide (3) est placé sur le bord de la partie cadre, et le bord (4) du guide (3) et la partie raclette (2) sont de côté principalement au même niveau.
Patent CA-2454941-A1 (CA)
Title: Folding modular greenhouse
Inventor: ARMSTRONG SHEILA MARY
IPC: A01G9/16
Filed: 2004-01-07
Abstract: A portable, modular greenhouse system that can be used to protect plants from harsh conditions. A green house according to the invention comprises a frame and a cover. The frame preferably comprises at least one panel constructed from a mesh of rigid wire, with a spacing between adjacent wires which is large enough to permit a gardener's hand to pass therethrough. The panels are preferably flexible and resilient, so that they return to their original shape after being bent.      The panels may be manufactured in a plurality of standard sizes, so that they may be used to construct frames varying widely in size and shape.      The frames are preferably able to be flattened for storage when the greenhouse is not being used. The cover preferably comprises a piece of light-transmitting plastic sized to fit over the frame. The shape of the cover will depend on the frame configuration. The cover preferably has sleeves formed in opposite edges thereof. Slats may be inserted into the sleeves, so that when the cover is on the frame the slats are located near the bottom of the frame, thereby weighing down the cover to keep it in place. The ends of the slats may be inserted through the mesh of the panels to further secure the cover to the frame.
Patent CA-2455338-A1 (CA)
Title: Liant hydraulique a vieillissement ameliore
Inventor: SARI MUSTAPHA
IPC: C04B28/02
Filed: 2002-07-15
Abstract: La présente invention concerne les liants minéraux comme les liants hydrauliques tels que ciments, mortiers ô vieillissement amélioré.Elle se rapporte plus particulièrement aux liants hydrauliques ô base de silicates minéraux présentant une meilleure résistance au vieillissement, un procédé d e fabrication de ces liants ainsi que leurs utilisations et articles obtenus avec de tels liants. L'invention consiste en l'addition d'un composé organiq ue comprenant deux fonctions hydrophiles et une chaine hydrophobe tels que l'acide adipique au liant hydraulique pour ralentir la vitesse de reprise en eau de ce liant.