Patent SG-11201807074V-A (SG)
Title: Novel pyrrolidine derivatives
Inventor: HAAP WOLFGANG
IPC: C07D417/12
Filed: 2017-02-22
Abstract: Title: NOVEL PYRROLIDINE DERIVATIVES F (I) W O 20 17 / 144483 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/144483 Al 31 August 2017 (31.08.2017) WIPO I PCT (51) International Patent Classification: CO7D 403/12 (2006.01) CO7D 401/12 (2006.01) A61K 31/4025 (2006.01) CO7D 403/14 (2006.01) A61K 31/41 (2006.01) CO7D 405/12 (2006.01) A61K 31/4155 (2006.01) CO7D 413/12 (2006.01) A61K 31/4192 (2006.01) CO7D 417/12 (2006.01) A61K 31/4196 (2006.01) CO7D 207/16 (2006.01) A61K 31/422 (2006.01) A61P 3/10 (2006.01) A61K 31/427 (2006.01) A61P 7/00 (2006.01) A61K 31/4439 (2006.01) A61P 7/02 (2006.01) A61K 31/506 (2006.01) (21) International Application Number: PCT/EP2017/053967 (22) International Filing Date: 22 February 2017 (22.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16157679.8 26 February 2016 (26.02.2016) EP (71) Applicant (for all designated States except US): F. HOFF- MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, 4070 Basel (CH). (71) Applicant US only): HOFFMANN-LA ROCHE INC. [US/US]; Overlook at Great Notch, 150 Clove Road, 8th Floor, Suite 8 - Legal Department, Little Falls, New Jersey 07424 (US). (72) Inventors: HAAP, Wolfgang; c/o F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel (CH). KUHN, Bernd; c/o F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel (CH). LUEBBERS, Thomas; c/o F. Hoff- mann-La Roche AG, Grenzacherstrasse 124, 4070 Basel (CH). PETERS, Jens-Uwe; c/o F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel (CH). (74) Agent: POMERANC, Didier; Grenzacherstrasse 124, 4070 Basel (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, [Continued on next page] 11111111111111011101111111111101011111011101011111111111111111111011111111111110111111 (57) : The invention relates to a compound of for- mula (I) wherein R 1 and R 2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament against diabetes, atherosclerosis and other conditions linked to cathepsin. WO 2017/144483 All#110HOMOIDEIR0101301011101110HEIMODEVOIMIE GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3))