baber/WOPTO huggingface dataset:
Patent CA-2891285-C (CA)
Title: Novel glucose oxidases derived from aspergillus niger
Inventor: BOCOLA MARCO
IPC: C12N9/54
Filed: 2014-01-28
Granted: 2021-05-04
Abstract: Disclosed herein are novel glucose oxidase variants having besides the two substitutions T30V and I94V according to SEQ ID NO: 1, additionally at least one further amino acid substitution in the polypeptide sequence in any of the positions S53; A137; A173; A332; F414; and V560. The thus optimized glucose oxidase variants exhibit specificity for glucose and significantly reduced oxygen-consumption rates. In another aspect, the present invention provides for glucose oxidase variants having significantly reduced oxygen-consumption rates and/or increased enzyme activity for electron mediators other than oxygen. The invention also provides for an assay device bearing at least one of the herein disclosed GOx variants for improved blood glucose measurements.
Patent CA-2898408-C (CA)
Title: Stabilite amelioree de compositions liquides nouvelles
Inventor: AGISIM GARY ROBERT
IPC: A61K31/137
Filed: 2014-02-13
Granted: 2018-01-02
Abstract: La présente invention concerne des compositions d'agents pharmaceutiques combinés à des agents pharmaceutiques supplémentaires dans un mélange de polyéthylèneglycol, de polyvinylpyrrolidone, et de propylglycol et un procédé de production des compositions.
Patent CA-2900548-C (CA)
Inventor: SANDU CORINA L
IPC: C09K15/06
Filed: 2014-02-19
Granted: 2017-08-22
Abstract: A composition useful for scavenging hydrogen sulfide by admixing metal carboxylates which have high viscosity due to polymerization and a viscosity improver selected from the group consisting of glycol ethers having from about 4 to about 10 carbons and alkyl alcohols having from about 1 to about 4 carbons.
Patent CA-2904248-C (CA)
Title: Systeme d'embrayage de treuil a distance
Inventor: AVERILL BRYAN M
IPC: B66D1/02
Filed: 2014-01-13
Granted: 2021-01-19
Abstract: L'invention porte sur un treuil, qui comprend un tambour rotatif et un train d'engrenages reliant en entraînement un moteur au tambour rotatif. Le train d'engrenages comprend un embrayage qui peut fonctionner de façon à être désengagé afin de permettre au tambour rotatif de produire un enroulement libre. Un actionneur d'embrayage est disposé pour désengager l'embrayage, et l'embrayage comprend un cliquet pivotant ayant une première extrémité qui vient en prise avec un taquet d'embrayage d'une couronne dentée planétaire, et l'actionneur d'embrayage comprend un électroaimant électromagnétique ayant un plongeur qui vient en prise avec une seconde extrémité du cliquet pivotant.
Patent CA-2905633-C (CA)
Title: Substituted aromatic compounds for the treatment of pulmonary fibrosis, liver fibrosis, skin fibrosis and cardiac fibrosis
Inventor: GAGNON LYNE
IPC: C07C59/52
Filed: 2014-03-14
Granted: 2021-12-28
Abstract: The present invention relates to substituted aromatic compounds for use in prevention or treatment of various fibrotic diseases and conditions in subjects, including pulmonary fibrosis, liver fibrosis, skin fibrosis and cardiac fibrosis, where the compound has the following formula: or a pharmaceutically acceptable salt thereof, wherein A is C5 alkyl, C6 alkyl, C5 alkenyl, C6 alkenyl, C(O)-(CH2)n-CH3 or CH(OH)-(CH2)n-CH3 wherein n is 3 or 4; R1 is H, OH or F; R2 is H, OH, F or CH2-OH; R3 is H, OH, F or CH2Ph; R4 is H, OH or F; Q is 1 ) (CH2)mC(O)OH wherein m is 1 or 2, 2) CH(CH3)C(O)OH, 3) C(CH3)2C(O)OH, 4) CH(F)-C(O)OH, 5) CF2-C(O)OH, or 6) C(O)-C(O)OH.
Patent CA-2909365-C (CA)
Title: 2-aminopyrido[4,3-d]pyrimidin-5-one derivatives and their use as wee-1 inhibitors
Inventor: O'DOWD COLIN RODERICK
IPC: A61P35/00
Filed: 2014-04-11
Granted: 2021-11-09
Abstract: The present invention relates to compounds of formula (I) that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.
Patent CA-2922287-C (CA)
Title: Furanoic polymer preforms, containers and processing
Inventor: KRIEGEL ROBERT M
IPC: B29D22/00
Filed: 2014-09-02
Granted: 2022-04-12
Abstract: Preforms and methods of processing 2,5-furandicarboxylic acid (FDCA) polymers, such as poly(ethylene-2,5-furandicaboxylate (PEF), to produce preforms and articles, such as containers. The present invention also includes preforms with superior processing characteristics and containers, such as PEF beverage bottles, with superior performance properties.
Patent CA-2923557-C (CA)
Inventor: POLYMEROPOULOS MIHAEL H
IPC: A61K31/704
Filed: 2014-09-04
Granted: 2023-10-24
Abstract: The invention relates generally to the treatment of CYR61- and VEGF-mediated conditions and, more particularly to the treatment of such conditions by administering to an individual a CYR61 downregulator. In one embodiment, the invention provides a method of treating a CYR61-mediated condition in an individual in need of such treatment, the method comprising: administering to the individual an effective amount of at least one CYR61 downregulator (CYR61DR), wherein the effective amount is an amount sufficient to decrease expression of the CYR61 gene in the individual.
Patent CA-2925061-C (CA)
Title: Nanocorps bispecifiques
Inventor: ROOBROUCK ANNELIES
IPC: C07K16/30
Filed: 2014-09-26
Granted: 2023-02-14
Abstract: Cette invention concerne des polypeptides bispécifiques comprenant un premier et un second domaine variable simple d'immunoglobuline (ISV), ledit premier ISV se liant à une première cible à la surface d'une cellule cancéreuse avec une faible affinité et, une fois lié inhibe une fonction de ladite première cible, et ledit second ISV se liant à une seconde cible à la surface de ladite cellule avec une forte affinité, ladite première cible étant différente de la seconde. Des procédés pour les identifier et les préparer sont en outre décrits.
Patent CA-2930047-C (CA)
Inventor: CARSON GLENN L
IPC: F28G15/00
Filed: 2016-05-16
Granted: 2021-11-02
Abstract: A cleaning apparatus includes a cable with spacers along the length of the cable for insertion into a tube with bends. Each of the spacers have a sphere-like body and have a diameter that is approximately the same as an inner diameter of the tube. Each neighboring pair of spacers are spaced apart from each other at approximately the same distance as the inner diameter of the tube. The cleaning apparatus is suited for passing through tubing within cracking furnaces and heat exchangers, which typically have many U-bends.
Patent CA-2935337-C (CA)
Inventor: FUNKHOUSER GARY P
IPC: C08G59/50
Filed: 2014-02-21
Granted: 2018-10-23
Abstract: Cementing compositions including a di- or poly epoxide resin, and amine hardener, and a di-or polyfunctional alkylphosphonate ester fortifier and methods of using the cementing compositions such as in a subterranean zone penetrated by a well bore.
Patent CA-2936790-C (CA)
Title: Thermal barrier coatings and processes
Inventor: CHEN DIANYING
IPC: C23C4/134
Filed: 2015-02-19
Granted: 2022-10-04
Abstract: Articles coated with a porous, segmented thermal barrier coating. The coating described has a density less than about 88% of the theoretical density. Multi-layer articles and methods of applying the thermal barrier coatings to an article are also described.
Patent CA-2936952-C (CA)
Title: Derives de chromene comme inhibiteurs cox-2
Inventor: TALLEY JOHN J
IPC: A61K31/352
Filed: 2015-01-14
Granted: 2023-01-24
Abstract: La présente invention concerne des conjugués de nitrooxy-chromène à libération de NO, présentant la structure représentée par la formule (I), dans laquelle R1, R2, R3, R4, X, et L sont tels que définis dans la description détaillée; des compositions pharmaceutiques comprenant au moins un composé représenté par la formule (I); ainsi que des procédés utiles pour la subérification de blessures, la prévention et le traitement du cancer et le traitement de la kératose actinique, de la fibrose cystique, et de l'acné, à l'aide d'un composé représenté par la formule (I).
Patent CA-2940079-C (CA)
Inventor: JOHANNESSON MATTIAS
IPC: G01B11/245
Filed: 2014-03-05
Granted: 2018-06-12
Abstract: An image sensing device (130) for providing image data relating to an image of an object (120; 121; 501) comprises an image sensor (131 ) having a sensor area (132) for sensing light. The image sensing device (130) defines (401) Regions Of Interest, "ROIs", (301 a-303a) in the sensor arca (132). Each ROI (301 a; 302a; 303a) partially overlaps one or more of the other ROIs (301 a-303a). The ROIs (301 a-303a) are exposed individually to light from the object. The image sensing device (130) reads (403) partial image data belonging to groups respectively associated with the exposed ROIs (301 a-303a) and resulting from sensed light therein. Image data relating to the image of the object is provided based on a combination of the read partial image data.
Patent CA-2940106-C (CA)
Inventor: VAN DEN BRINK RICHARD RUDOLF THEODOOR
IPC: A61J7/00
Filed: 2015-02-23
Granted: 2022-10-04
Abstract: A method of receiving and checking individualized compound doses of medicines is disclosed. The method includes a repetition of the steps of - receiving a plurality of dispensed medicines that form an individualized compound dose of medicines, - assessing the composition of the individualized compound dose of medicines trough automated recognition of the received medicines, - checking the assessed composition of the received individualized compound dose of medicines against a record for the composition of that individualized compound dose of medicines, and - if the outcome of the check is positive, discharging the received individualized compound dose of medicines to be packaged in a dose compartment of a multi dose compartment package, and - if the outcome of the check is negative, discharging the received individualized compound dose of medicines other than to be packaged in a dose compartment of the multi dose compartment package. The disclosure also includes a device for receiving and checking individualized compound doses of medicines.
Patent CA-2940583-C (CA)
Inventor: LEE HO YOUNG
IPC: B01D11/02
Filed: 2014-03-28
Granted: 2019-05-07
Abstract: There is disclosed a super critical hydrolysis extraction apparatus including a pressure container comprising a body and a lid coupled to the body to close a space formed therein to accommodate an object; a contact unit configured to open and close the body, while moving the lid forward and backward; and a pipeline unit comprising a supply line where a liquid for filling in the pressure container and a discharge line for discharging the liquid of the pressure container.
Patent CA-2943290-C (CA)
Title: Thermoforming sheets and thermoformed containers prepared therefrom
Inventor: SANDERS DANIEL CLAYTON
IPC: B65D77/20
Filed: 2015-04-02
Granted: 2023-04-25
Abstract: Forming webs and packages are provided having improved sealability to peelable lidstocks. The thermoformed containers (12) may have a mouth (14) having an opening and a flange being disposed about the opening, the flange formed from a forming web and having a thickness greater than about 12 mils and up to about 80 mils. The forming web may have a base layer (20) with a skim coating (24) thereon, a portion of the skim coating being on the flange having a skim coating thickness from about 2 mils to about 8 mils. A peelable lid (18) may include a film (28) with an inner lid sealant layer (26) which is sealed to the portion of the skim coating on the flange, the skim coating and inner lid sealant layer each having a common polyolefin majority component, the common polyolefin component being different than a majority component of the base layer.
Patent CA-2945678-C (CA)
Title: Circuit d'alimentation electrique dote d'une protection de sous-tension active
Inventor: SOLOMON SALIM
IPC: H02H7/10
Filed: 2015-02-10
Granted: 2019-03-05
Abstract: L'invention concerne un circuit d'alimentation électrique qui comprend un circuit de protection interconnecté avec une tension d'entrée à l'alimentation électrique. Le circuit de protection comprend un circuit de détection pour détecter si une grandeur de la tension d'entrée est inférieure à un seuil défini. Le circuit de détection comprend une pluralité de détecteurs, chacun permettant de détecter, pour une forme d'onde de tension définie, si sa grandeur est inférieure ou non à une tension de seuil définie. Des interconnexions logiques du circuit de détection fournissent un signal de commande destiné à empêcher l'alimentation électrique de fournir ladite tension de sortie si la tension d'entrée est inférieure au seuil défini pour cette forme d'onde de tension définie, comme détecté par le circuit de détection.
Patent CA-2951522-C (CA)
Title: Extensible design of nesting supplemental enhancement information (sei) messages
Inventor: RAMASUBRAMONIAN ADARSH KRISHNAN
IPC: H04N19/34
Filed: 2015-06-18
Granted: 2019-08-20
Abstract: In an example, a method for video coding includes processing a Supplemental Enhancement Information (SEI) Network Abstraction Layer (NAL) unit that comprises one or more SEI message structures in a raw byte sequence payload (RBSP), such that one or more SEI message structure includes at least one nesting SEI message structure having one or more SEI messages. In various embodiments, the SEI NAL unit is processed, and a syntax element, indicative of a number of SEI messages comprised within the at least one nesting message structure, is coded.
Patent CA-2954233-C (CA)
Title: Wiper blade assembly protector and method of protecting a wiper blade assembly
Inventor: DEGENNARO SERGIO K
IPC: B60S1/04
Filed: 2017-01-06
Granted: 2019-05-21
Abstract: A protector for a windshield wiper assembly includes an elongated body defining a cavity receiving at least the blade of the wiper assembly. The cover is used to protect the assembly from snow, ice, mud, etc. Preferably, the assembly is pivoted away from the windshield before the blade is inserted into the body. Caps with decorative covers are provided at the ends of the body. The body may be made of a translucent material and may be covered with logos, insignia and other advertising materials.
Patent CA-2957503-C (CA)
Inventor: MALLIKARJUNA CHALLA BALAIAH
IPC: F02B3/00
Filed: 2015-08-04
Granted: 2022-11-29
Abstract: Cette invention concerne un système de génération d'énergie hydroélectrique à partir d'un canal à écoulement hypocritique. Ledit système comprend un canal de production d'énergie dévié à partir du canal à écoulement hypocritique pour générer de l'énergie hydroélectrique en modifiant un ou plusieurs paramètres d'écoulement de l'eau, ledit canal de production d'énergie comprenant une section d'admission, une ou plusieurs section(s) inclinée(s), une ou plusieurs section(s) de génération d'énergie et une section de récupération, un déversoir d'admission au niveau de la section d'admission du canal de génération d'énergie, reliant le canal à écoulement hypocritique au canal de génération d'énergie pour augmenter la vitesse de l'eau, ledit déversoir d'admission étant conçu sur la base d'une vitesse de décharge de l'eau à puiser à partir du canal à écoulement hypocritique, et un ensemble de turbines disposé dans le canal de génération d'énergie pour générer de l'énergie au moyen de l'eau déviée à partir du canal à écoulement hypocritique, le nombre des turbines dépendant de la longueur du canal de génération d'énergie.
Patent CA-2958777-C (CA)
Title: Aliment pour poissons et procede de smoltification et de prevention de la desmoltification chez les salmonides, et de prophylaxie et de traitement du syndrome du smolt hemorragique (ssh) chez les salmonides
Inventor: LYNGOY ARTHUR
IPC: A61K33/14
Filed: 2015-09-22
Granted: 2022-10-11
Abstract: L'invention concerne un aliment pour poissons utile dans un procédé de smoltification et de prévention de la désmoltification chez les salmonidés, et de prophylaxie et de traitement du syndrome du smolt hémorragique (SSH) chez les salmonidés. L'aliment contient des protéines, des graisses, des glucides, des vitamines, des minéraux et de l'eau, et comprend en outre des sels de sodium (Na+) en une quantité de 10 à 100 g/kg en poids, un modulateur de récepteur des cations polyvalents (PVCR) en une quantité de 1 à 10 g/kg en poids, des sels de magnésium (Mg2 +) en une quantité de 0,1 à 100 g/kg en poids, et des sels de calcium (Ca2+) en une quantité de 0,1 à 100 g/kg en poids.
Patent CA-2962222-C (CA)
Title: Residual-stress measurement device and residual-stress measurement method
Inventor: KOBAYASHI YUJI
IPC: G01N23/207
Filed: 2015-11-30
Granted: 2021-06-15
Abstract: This residual-stress measurement device is provided with an X-ray source (10) for irradiating X-rays at a specimen (S) to be measured; a first detection element (11A) for detecting, at a first detection position, the intensity of X-rays diffracted from the specimen to be measured; a second detection element (11B) for detecting, at a second detection position different from the first detection position, the intensity of X-rays diffracted from the specimen to be measured; a movement mechanism (120) for causing each of the first detection element and the second detection element to move along a straight line extending in a direction orthogonal to the direction of incidence of the X-rays; a movement control unit (21) for controlling the detection positions of each of the first detection element and the second detection element by driving the movement mechanism; and a stress calculation unit (22) for calculating the residual stress of the specimen to be measured on the basis of peaks in intensity of the diffracted X-rays detected due to each of the first detection element and the second detection element being moved by the movement mechanism. According to the present invention, it is possible to shorten the time for measuring residual stress.
Patent CA-2964501-C (CA)
Title: Echafaudage en biomateriau pour regeneration de la muqueuse orale
Inventor: CASTRO FEO BEGONA
IPC: A61L27/26
Filed: 2015-10-23
Granted: 2023-05-16
Abstract: La présente invention se rapporte à un procédé de préparation d'un échafaudage en biomatériau, ledit procédé comprenant les étapes consistant à : (a) fournir un hydrogel comprenant un réseau de fibrine et un réseau de polysaccharides ; (b) soumettre l'hydrogel de l'étape (a) à un processus de congélation-décongélation pour réticuler physiquement l'hydrogel ; et (c) soumettre l'hydrogel physiquement réticulé obtenu à l'étape (b) à une lyophilisation. L'invention concerne également l'échafaudage en biomatériau pouvant être obtenu par le procédé tel que défini ci-dessus, ainsi que ledit échafaudage en biomatériau dans le cadre de son utilisation pour augmenter, restaurer ou remplacer partiellement ou complètement l'activité fonctionnelle d'une muqueuse orale malade ou endommagée.
Patent CA-2965154-C (CA)
Inventor: GAGLIARDINO JOSEPH L
IPC: B61G3/04
Filed: 2009-09-17
Granted: 2019-10-08
Abstract: Un attelage de wagon porte-rails comprenant une partie tête dattelage sétendant depuis une partie tige. La partie tête dattelage est configurée pour satteler à une première mâchoire dattelage pour atteler lattelage de wagon à un second attelage de wagon dun wagon adjacent. La partie tête dattelage comprend une partie nez et une face de jonction sétendant à partir de la partie nez pour venir en prise avec une seconde mâchoire dattelage attelée au second attelage de wagon. La partie tête dattelage comprend une partie guide dattelage sétendant de la partie nez à la partie tige. La partie tête dattelage présente une configuration permettant une distance de déplacement supérieure à environ 4,5 pouces par rapport à une gâche de wagon porte-rails pendant lattelage au second attelage de wagon du wagon adjacent, tandis quune distance entre lextrémité nez de la partie guide dattelage et la gâche de wagon est denviron 15,75 pouces avant lattelage au second wagon.
Patent CA-2965645-C (CA)
Title: Determining dominant scenarios for slowing down trip speeds
Inventor: WISE MATTHEW EDWIN
IPC: E21B44/00
Filed: 2014-12-02
Granted: 2020-07-14
Abstract: A trip speed table is created containing records. Each record contains a step location, wherein a step is defined to be the location in a well of a deepest end of a drill string, a minimum trip speed for the step location, wherein the minimum trip speed is defined to be the maximum trip speed less than or equal to a default trip speed at which the drill string can be tripped without exceeding a fracture gradient or falling below a pore pressure at a slice depth, and the slice depth where the minimum trip speed for the step location occurred.
Patent CA-2968705-C (CA)
Inventor: MAGAROTTO ROBERTA
IPC: D06M10/08
Filed: 2015-08-10
Granted: 2022-11-22
Abstract: La présente invention concerne des fibres de polyoléfine modifiées en surface, l'utilisation de ces fibres dans des compositions de liant hydraulique, des compositions de liant hydraulique contenant ces fibres et un procédé pour le renforcement de compositions de liant hydraulique.
Patent CA-2969388-C (CA)
Inventor: RABINOVITCH YONI
IPC: G08B25/10
Filed: 2015-11-18
Granted: 2023-10-10
Abstract: A remote-control security monitoring system, including an access peimissions receiver operable for receiving, from a first entity having first access permissions to the premises automation system, second access permissions to the premises automation system, a premises monitoring selector operable for receiving, from the first entity, a selection of a second entity which provides remote monitoring services, a premises monitoring remote-control provider operable, responsive to the selection of the second entity, for subscribing the first entity to receive remote monitoring services of the premises from the second entity, and a premises monitoring activator operable, responsive to subscribing the first entity to receive the remote monitoring services from the second entity and responsive to receiving an instruction from the first entity, for instructing the second entity to monitor the premises on behalf of the first entity.
Patent CA-2970986-C (CA)
Inventor: MERTENS NICO
IPC: C07K16/30
Filed: 2015-12-21
Granted: 2021-10-26
Abstract: The present invention relates to a bispecific binding molecule comprising three binding domains, wherein a first and/or a second binding domain are capable of binding to the extracellular 5T4 antigen and the remaining binding domain(s) is (are) capable of binding to the CD3 receptor complex on T cells. Moreover, the invention relates to a nucleic acid sequence encoding fusion protein, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention relates to a process for the production of the fusion protein of the invention, a medical use of said fusion protein and a kit comprising said fusion protein.
Patent CA-2971445-C (CA)
Title: Method of filtering particulates from the air using a composite filter substrate comprising a mixture of fibers
Inventor: MORISON PAMELA MARIE
IPC: B01D39/08
Filed: 2015-12-16
Granted: 2020-06-16
Abstract: A method of filtering air using a composite filter substrate having a mixture of fiber shapes and sizes layer is disclosed. The method provides improved particle cleaning efficiency.