baber/WOPTO huggingface dataset:
Patent DE-69631480-D1 (DE)
Inventor: NATSOULIS GEORGES
IPC: C07K14/015
Filed: 1996-08-01
Granted: 2004-03-11
Abstract: Novel nucleic acid molecules are provided having adeno-associated virus (AAV) coding regions that are capable of expressing necessary AAV functions to complement an AAV vector in the production of recombinant AAV (rAAV) virions. The molecules feature a nucleotide sequence that is substantially homologous to an AAV p5 promoter region, wherein the p5 promoter region is situated in the molecules in a site that is other than its natural position relative to the AAV  rep  coding region in the wild-type AAV genome. AAV helper function constructs are also provided, comprising the instant nucleic acid molecules embodied in a replicon that is capable of being transcribed and translated to express complementing AAV helper functions in a suitable host cell. Novel AAV packaging cells and AAV producer cells are provided, which contain the AAV helper constructs of the invention, and methods of producing enhanced levels of rAAV virions using the AAV helper constructs of the invention are also provided. Methods are also provided for producing rAAV virions without the concomitant production of significant levels of wild-type AAV.
Patent DE-69634136-D1 (DE)
Inventor: PAASONEN ANDERS
IPC: B29C39/10
Filed: 1996-04-04
Granted: 2005-02-03
Abstract: The problems caused by chemical and thermal shrinkage of hard roll covers, are reduced by the inclusion of one or more intermediate compressive layers between the metal roll and the outer cover, or "topstock". A compressive layer has the properties of being rigid enough to allow the cover to be applied to the roll, and compressible enough to buffer and absorb the stresses which occur as the cover is shrinking during processing. In one embodiment, the intermediate compressive layer comprises a three dimensional fabric that is filled preferably with a thermoset resin system which cures at lower temperature than cover. In a second embodiment, the precise amount of shrinkage in the roll can be predetermined to a high enough degree of accuracy so that a depth for the fabric layer can be used to compensate for the amount of shrinkage, thereby eliminating the need for filling. In a third embodiment, the compressive layer is comprised of a wax material. The problems caused by chemical and thermal shrinkage are further reduced through a method based on applying a polymeric cover layer over one or more intermediate compressive layers, curing at an elevated temperature, and, allowing the cover to shrink during curing or hardening.
Patent DE-69705916-D1 (DE)
Inventor: PELEMAN GUIDO
IPC: B42F7/14
Filed: 1997-10-02
Granted: 2001-09-06
Abstract: File, consisting of a front sheet (2) and a rear sheet (3) made of a rigid material which are connected to each other by a flexible back (4), and whereby at least one of the said sheets (2-3) is provided with an inwardly directed flap (5) which is kept at its side edges by means of connecting pieces (6) at a distance from the concerned sheet (2-3) to which this flap (5) is attached characterized in that the connecting pieces (6) are at least attached to the concerned sheet (2-3) and the flap (5) by means of mere mechanical connections. <IMAGE>
Patent DE-69712979-D1 (DE)
Inventor: CORGHI REMO
IPC: B60C25/132
Filed: 1997-04-02
Granted: 2002-07-11
Abstract: A machine for removing and mounting tyres from and onto respective wheel rims comprises a base (1; 20), a platform (3; 22) rotating on the base, and a column (7; 26) which extends vertically upwards from the base to the side of the platform and supports, one following the other, two mutually slidable elements one of which carries at its end the tool (15; 33) which is to operate on the tyre bead, the element which supports the tool being also secured to the centre of the wheel rim. <IMAGE>
Patent DE-69714264-D1 (DE)
Inventor: LIGHTLE D
IPC: B29C48/03
Filed: 1997-08-11
Granted: 2002-08-29
Abstract: A horizontal vacuum extrusion line includes a fixed bulkhead (23), a die (24) inside the bulkhead, a telescoping vacuum chamber section (27) and fixed chamber sections (28,29). A dam (33) in the fixed section forms a pond (72) for immersion cooling of the extrudate. A truss (35) extends from the dam to the bulkhead supporting shaping and calibration equipment and extends through the telescoping section. Fluid pressurizable seals at each end of the telescoping section are operable after the telescoping section is closed against the bulkhead and the telescoping and fixed sections are locked together. The telescoping section provide a more compact line and easier access to the complex equipment downstream of the die. The extrudate from the die passes down into the pond (72) and then through an orifice (74) in a hood (75) projecting from the chamber into a lower level portion of the pond (78) exposed to atmosphere. The hood also includes a tractor drive (88) to push the extrudate through the underwater orifice. The hood and its contents are accessible through the atmospheric pond. A tractor haul-off and the tractor drive in the hood are the only extrudate drives between the calibration equipment and atmosphere. The higher level of the pond (72) within the chamber downstream of the dam is controlled by a valve in turn controlling the output of a pump. The valve control senses the pond level and operates independently of the vacuum controls. <IMAGE> <IMAGE>A horizontal vacuum extrusion line includes a fixed bulkhead (23), a die (24) inside the bulkhead, a telescoping vacuum chamber section (27) and fixed chamber sections (28,29). A dam (33) in the fixed section forms a pond (72) for immersion cooling of the extrudate. A truss (35) extends from the dam to the bulkhead supporting shaping and calibration equipment and extends through the telescoping section. Fluid pressurizable seals at each end of the telescoping section are operable after the telescoping section is closed against the bulkhead and the telescoping and fixed sections are locked together. The telescoping section provide a more compact line and easier access to the complex equipment downstream of the die. The extrudate from the die passes down into the pond (72) and then through an orifice (74) in a hood (75) projecting from the chamber into a lower level portion of the pond (78) exposed to atmosphere. The hood also includes a tractor drive (88) to push the extrudate through the underwater orifice. The hood and its contents are accessible through the atmospheric pond. A tractor haul-off and the tractor drive in the hood are the only extrudate drives between the calibration equipment and atmosphere. The higher level of the pond (72) within the chamber downstream of the dam is controlled by a valve in turn controlling the output of a pump. The valve control senses the pond level and operates independently of the vacuum controls. <IMAGE> <IMAGE>
Patent DE-69717268-D1 (DE)
Inventor: MADUSKUIE PETER
IPC: C07D237/24
Filed: 1997-02-18
Granted: 2003-01-02
Abstract: The present application describes m-amidino phenyl analogs of formula (I), wherein D can be amidino and E can be phenyl, which are useful as inhibitors of factor Xa.
Patent DE-69720583-D1 (DE)
Inventor: DINH JOHN S
IPC: A61M25/00
Filed: 1997-05-07
Granted: 2003-05-15
Abstract: An intravascular catheter (10,110) having an elongated tubular body with a proximal portion, a distal portion and a lumen extending therebetween. The tubular body is formed with polymeric materials, preferably containing no radiopaque filler, and metallic reinforcing braiding (22,130) configured to provide the catheter (10,110) with radiopaque properties and/or kink resistance. <IMAGE>
Patent DE-69722465-D1 (DE)
Inventor: SMART G
IPC: B22F9/26
Filed: 1997-10-06
Granted: 2003-07-03
Abstract: A method for dissociating metal-ligand complexes in a supercritical fluid by treating the metal-ligand complex with heat and/or reducing or oxidizing agents is described. Once the metal-ligand complex is dissociated, the resulting metal and/or metal oxide form fine particles of substantially uniform size. In preferred embodiments, the solvent is supercritical carbon dioxide and the ligand is a  beta -diketone such as hexafluoroacetylacetone or dibutyldiacetate. In other preferred embodiments, the metals in the metal-ligand complex are copper, silver, gold, tungsten, titanium, tantalum, tin, or mixtures thereof. In preferred embodiments, the reducing agent is hydrogen. The method provides an efficient process for dissociating metal-ligand complexes and produces easily-collected metal particles free from hydrocarbon solvent impurities. The ligand and the supercritical fluid can be regenerated to provide an economic, efficient process.
Patent DE-69723978-D1 (DE)
Inventor: MACLENNAN A
IPC: H01J61/42
Filed: 1997-05-29
Granted: 2003-09-11
Abstract: A light emitting device comprised of an electrodeless envelope (19') which bears a light reflecting covering (10') around a first portion which does not crack due to differential thermal expansion and which has a second portion which comprises a light transmissive aperture (12'). The light emitting device may further comprise an optical element (72) spaced from the envelope (19') and configured to reflect an unwanted component of light which exited the envelope (19') back into the envelope (19') through the aperture (12') in the light reflecting covering (10'). <IMAGE>
Patent DE-69728537-D1 (DE)
Inventor: LERNER A
IPC: C07C69/738
Filed: 1997-06-26
Granted: 2004-05-13
Abstract: Inhibitors of oleamide hydrolase, responsible for the hydrolysis of an endogenous sleep-inducing lipid (1, cis-9-octadecenamide) were designed and synthesized. The most potent inhibitors possess an electrophilic carbonyl group capable of reversibly forming a (thio) hemiacetal or (thio) hemiketal to mimic the transition state of a serine or cysteine protease catalyzed reaction. In particular, the tight binding  alpha -keto ethyl ester 8 (1.4 nM) and the trifluoromethyl ketone inhibitor 12 (1.2 nM) were found to have exceptional inhibitory activity. In addition to the inhibitory activity, some of the inhibitors displayed agonist activity which resulted in the induction of sleep in laboratory animals.
Patent DE-69730353-D1 (DE)
Inventor: INGLE FRANK
IPC: A61N1/40
Filed: 1997-11-05
Granted: 2004-09-23
Abstract: Devices, systems, and method for treating urinary incontinence generally relying on energy delivered to a patient's pelvic support tissue to selectively contract or shrink at least a portion of that pelvic support tissue so as to reposition the bladder. The energy will preferably be applied to the endopelvic fascia and/or an arcus tendineus fascia pelvis. A variety of devices and methods are provided for applying gentle resistive heating of these and other tissues to cause them to contract without imposing significant injury on the surrounding tissue structures. By applying sufficient energy over a predetermined time, the tissue can be raised to a temperature which results in contraction without significant necrosis or other tissue damage. By selectively contracting the support tissues, the bladder neck, sphincter, and other components of the urinary tract responsible for the control of urinary flow can be reconfigured or supported in a manner which reduces urinary leakage.
Patent DE-69730869-D1 (DE)
Inventor: FOSGATE WAYNE
IPC: H04S7/00
Filed: 1997-03-14
Granted: 2004-10-28
Abstract: A surround sound processor for redistribution of stereophonic audio signals into multiple channels for presentation on a plurality of loudspeakers surrounding a listener has an improved direction detector filter circuit, a peak hold circuit in the direction detector for better dynamic separation, improved time constants in the servologic circuit, improved linearity correction in the control voltage generator to match the characteristics of the new voltage controlled amplifiers which are applied to the separation matrix, a separation matrix having cancellation of unwanted signals wihtout gain modification for desired signal components, and improved shelf filters in the rear channel outputs.
Patent DE-69734356-D1 (DE)
Inventor: COHEN P
IPC: A61P3/10
Filed: 1997-02-19
Granted: 2006-02-23
Abstract: The present invention is directed to preventing the nonenzymatic glycation of albumin, which generates biologically active Amadori glucose adducts in the albumin molecule, as well as methods of using compounds that protect albumin against nonenzymatic glycation to prevent vasculopathy. The present invention also is directed to preventing the nonenzymatic glycation of apolipoprotein B in low density lipoproteins, which generates Amadori glucose adducts in the apo B molecule that predispose to lipid oxidation and to LDL-cholesterol internalization leading to foam cells, as well as methods of using compounds that protect apo B/LDL against nonenzymatic glycation to prevent atherosclerosis and to reduce serum cholesterol levels.
Patent DE-69805821-D1 (DE)
Inventor: DEN OS ANNA
IPC: G10L17/00
Filed: 1998-09-15
Granted: 2002-07-11
Abstract: A method of and an arrangement for obtaining reference information comprising speech parameter data and variability data from test or enrollment speech (2) of an individual. Classes of speakers are defined, each class comprising speech parameter data and variability data of said speech parameter data, obtained from speech of a plurality of speakers. Speech parameter data (3) of the test or enrollment speech (2) are obtained and variability data are allocated to the speech parameter data in accordance with variability data of the class of speakers assigned to the individual. The speech parameter data (3) and allocated variability data comprise the above reference information (5). With the reference information (5) thus obtained an improved method and arrangement for speaker verification is provided. <IMAGE>
Patent DE-69806174-D1 (DE)
Inventor: FLODIN YNGVE
IPC: B65D88/12
Filed: 1998-07-30
Granted: 2002-07-25
Abstract: The invention relates to a container lock including an upper and a lower locking lug (1, 24) capable of being passed into a respective lock groove (51, 53) in juxtaposed container corners (50, 52) and turned so as to lock therein in that the lower locking lug (24) is rotatably and translationally mounted in a housing (21) connected to the upper locking lug (1) and having a shaft (14) capable of limited movement in the axial direction, which is lock-actuated by a spring (9) in the housing (21) in a downward direction, and between the housing (5, 21) and the shaft (14) there are arranged guide means (13, 8) which permit a locking rotation of the lower locking lug (24) on upward movement of the shaft (14). The invention is characterized in that the lower locking lug (24) is designed to have a pressure ball (25) intended for abutting interaction with a bottom of a lock groove (53) when an upper container is placed on a lower container. The housing (21) can thus be pressed down onto the shaft (14), whereby a gap is formed between a downward facing circumferential annular surface on the shaft (14) and the lower part of the housing (21), and in the housing (21) there is arranged a locking device including spring-actuated (31) locking arms (16, 17) which will move in towards the shaft (14) to a position in the gap below the circumferential annular surface and thus as a spacer prevent the return axial movement of the shaft (14).
Patent DE-69811004-D1 (DE)
Inventor: DONA SEVERINO
IPC: B60J7/06
Filed: 1998-07-01
Granted: 2003-03-06
Abstract: Connecting device for arcs (7) of accordion-coverings, including at least one flexible band (1) stiffened in at least two separate portions of almost equal length, e.g. by two rigid members (3) connected through said flexible band (1). each of the two rigid members (3) being connected to an arc (7) of the accordion-covering preferably through a further flexible band (4). The present invention also relates to an accordion-covering including a plurality of arcs (7) connected through at least one connecting device according to the present invention. <IMAGE>
Patent DE-69816477-D1 (DE)
Inventor: BONNAIN JEAN-CHRISTOPHE
IPC: B31B50/80
Filed: 1998-09-21
Granted: 2003-08-21
Abstract: A packaging machine for packaging articles into cartons selected from, at least, a first carton or a second carton is described, wherein the first and second cartons are of a different type or size. The cartons are stored in at least one hopper, and picked for packing by a carton engaging means arranged to remove cartons from said at least one hopper and transport them sequentially to a first predetermined position. From there the cartons are transferred to a paper feed chain which transports the cartons to a second predetermined position, from where the cartons are combined with said articles. The paper feed chain comprises a support means carrying a first endless chain from which is depended a first set of guide lugs and a second endless chain from which is depended a second set of guide lugs. The guide lugs are interleaved to produce carton receiving zones, the length of which can be altered, for different carton sizes or types, by altering the relative positions of the first and second set of guide lugs. The support means is movable such that when the relative positions of the lugs is changed, this change can be compensated for such that the position of the first set of lugs with respect to said first predetermined position is unaltered.
Patent DE-69819371-D1 (DE)
Inventor: COOK GORDON JAMES
IPC: B29C45/14
Filed: 1998-02-25
Granted: 2003-12-04
Abstract: A method of constructing a polymer support frame (10) over which woven wire cloth (158,159) is to be stretched and secured to form a sifting screen is described. The method comprises the steps of locating a reinforcing wire frame assembly in a mould tool. The wire frame comprises two parallel spaced apart arrays of reinforcing wires (48,50,54,56,60,62,64). After closing the mould, liquid polymer is injected into the mould tool so as to wholly encapsulate the wire frame and to form an article having an open central region criss-crossed by intersecting orthogonal ribs (14,16) bounded on all sides by a rigid flange. Each of the ribs (14,16) contains two of the parallel spaced apart wires of the frame assembly. After permitting the polymer to cure, the tool is opened and the article is removed. The wire frame assembly is located and held in shape and position by applying an inward force on opposite faces of the wire frame assembly within the mould tool, by fingers protruding inwardly from inside faces of the tool. The fingers engage the wire matrices when the tool closes. The polymer is typically a glass-reinforced plastics material, and in order to assist in bonding the wire cloth to the support frame (10) the faces of peripheral edge regions of the support frame (10) over which woven cloth (158,159) is laid and to which the cloth (158,159) is to be bonded by heating, are formed during moulding with a plurality of substantially parallel ridges (30,32).
Patent DE-69819678-D1 (DE)
Inventor: CHECA TORRES ANTONIO AGUSTIN
IPC: G03B19/12
Filed: 1998-06-19
Granted: 2003-12-18
Abstract: Device for the alternate or simultaneous filming of still and video pictures or multipurpose camera, characterized by the combination of a video camera and a still camera in one single device which is equipped with a single interchangeable lens, an optical assembly, in addition to a system of prisms, mirrors or other similar reflecting components, which transmit the virtual image, understood as being the image which has not undergone any electrical, magnetic or digital processing, duplicated to a video mechanism and to a still picture mechanism for its individual, alternate or simultaneous processing. <IMAGE>
Patent DE-69829339-D1 (DE)
Inventor: CATRON H
IPC: C07C51/41
Filed: 1998-01-30
Granted: 2005-04-21
Abstract: The present invention relates to metal carboxylates and more particularly to chromium(III) and manganese(II) salts of short chain fatty acids. A method of making the same such that there are only sub part per billion amounts of these metals in other valent forms present in the resultant salts, and the salts are suitable for use as nutritional supplementation of living organisms with the organic metal salts.
Patent DE-69832399-D1 (DE)
Inventor: SWENDSON L
IPC: A61M5/31
Filed: 1998-09-24
Granted: 2005-12-22
Abstract: A one-handed blood sampling reservoir for an infusion line having a configuration which allows discard fluid to be drawn into the reservoir and then returned to the patient in two squeezing motions. Both drawing and returning steps are performed by squeezing two of a plurality of finger grips provided on the reservoir. The reservoir may include a bracket which enables one-handed operation in either a hand-held or a pole-mounted configurations. In the alternative, the reservoir and finger grips may be formed by telescoped inner and outer housings without a bracket. The reservoir desirably includes a syringe-like body forming a chamber and a plunger/piston assembly reciprocal therein to vary the volume of the chamber. A narrow gap is provided in the chamber open to both inlet and outlet ports when the piston is fully seated to ensure a consistent and minimum flush volume in the chamber. The piston may be spring-loaded against the syringe body to simplify manufacturing by reducing the number of close toleranced parts required. The reservoir is preferably placed within an infusion line having a pressure transducer therein, and the spring loaded piston may be adjustable to vary the dynamic response of the fluid pressure system.
Patent DE-69832781-D1 (DE)
Inventor: OLSSON FREDRIK
IPC: H04Q11/04
Filed: 1998-03-02
Granted: 2006-01-19
Abstract: Sequence integrity and frame integrity are preserved in switching wideband connections through a switch or a switch stage. The speech memory in a switch stage in the switch is extended to include storage positions that in number correspond to the number of time slots in two frames. These storage positions are arranged into two parts of the same size in the speech memory. Furthermore, there is provided a delay control unit in the time switch stage for generating delay information based on control information in the control memory of the switch stage and a determined part of the counter information from a time slot counter circuit. This delay information controls, for each time slot, to/from (depending on if the speech memory is arranged in an outgoing stage or an incoming stage) which one of the first and second parts of the speech memory that user data is switched.
Patent DE-69835610-D1 (DE)
Inventor: HAGER W
IPC: H01J49/42
Filed: 1998-10-29
Granted: 2006-09-28
Abstract: A method is provided of operating a mass spectrometer having first and second rod sets, which can be a focusing set of rods and an analysis rod set, the second rod set being downstream from the first rod set at an outlet of a spectrometer. Ions are directed into the first rod set and an RF voltage applied to the two rod sets, the RF voltage can be the same or different for the two rod sets. A low level DC voltage is applied to the first rod set sufficient to reduce a continuum background ion signal, thereby to increase the signal-to-noise ratio of the spectrometer.
Patent DE-69836033-D1 (DE)
Inventor: PAPPAS MICHAEL J
IPC: A61F2/38
Filed: 1998-06-17
Granted: 2006-11-09
Abstract: A prosthetic joint is provided including a meniscal bearing platform (10), bearing components (26, 28), and a femoral component (50). The tibial platform (10) is formed to allow for sliding movement of the bearing components (26, 28) thereabout. The movement of the bearing components (26, 28) is constrained to a predetermined path of movement by the combination of a raised portion (16) extending from the tibial platform (10), as well as lateral constraint provided by the femoral component (50).