Patent SG-11201908228T-A (SG)
Title: Chemical compounds
Inventor: HARRISON DAVID
IPC: C07D261/08
Filed: 2018-03-12
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIP0 I PCT omit VIII °nolo omioomomiu Imo ois (10) International Publication Number WO 2018/167468 Al (51) International Patent Classification: C07D 231/12 (2006.01) C07D 261/08 (2006.01) C07D 231/14 (2006.01) C07D 271/10 (2006.01) C07D 233/10 (2006.01) CO7C 13/00 (2006.01) C07D 233/96 (2006.01) CO7D 213/06 (2006.01) C07D 237/08 (2006.01) A61K 31/64 (2006.01) C07D 239/26 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/GB2018/050623 (22) International Filing Date: 12 March 2018 (12.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1703979.3 13 March 2017 (13.03.2017) GB (71) Applicant: NODTHERA LIMITED [GB/GB]; 137a George Street, Edinburgh EH2 4JY (GB). (72) Inventors: HARRISON, David; c/o Nodthera Limited, 137a George Street, Edinburgh EH2 4JY (GB). WATT, Alan Paul; c/o Nodthera Limited, 137a George Street, Ed- inburgh EH2 4JY (GB). BOUTARD, Nicolas; c/o Selvi- ta S.A Park Life Science, ul. Bobrzynskiego 14, 30-348, Krakow (PL). FABRITIUS, Charles-Henry; c/o Selvi- ta S.A Park Life Science, ul. Bobrzynskiego 14, 30-348, Krakow (PL). GALEZOWSKI, Michal; c/o Selvita S.A Park Life Science, ul. Bobrzynskiego 14, 30-348, Krakow (PL). KOWALCZYK, Piotr; c/o Selvita S.A Park Life Science, ul. Bobrzynskiego 14, 30-348, Krakow (PL). LEV- ENETS, Oleksandr; c/o Selvita S.A Park Life Science, ul. Bobrzynskiego 14, 30-348, Krakow (PL). WOYCIE- CHOWSKI, Jakub; c/o Selvita S.A Park Life Science, ul. Bobrzynskiego 14, 30-348, Krakow (PL). (74) Agent: STRATAGEM IPM LIMITED; Meridian Court, Comberton Road, Toft, Cambridge Cambridgeshire CB23 2RY (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) W O 20 18/167 468 Al (54) Title: CHEMICAL COMPOUNDS (57) : The present disclosure relates to compounds of Formula (I): and to their pharmaceutically acceptable salts, pharmaceutical compo- sitions, methods of use, and methods for their preparation. The compounds disclosed herein inhibit the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inter alia autoinflam- matory and autoimmune diseases and cancers. (I)