baber/WOPTO huggingface dataset:
Patent WO-2021055495-A1 (WO)
Title: Methods and systems for selective nucleic acid depletion
Inventor: BROWNE PATRICK
IPC: C12N5/071
Filed: 2020-09-16
Abstract: The present disclosure provides a method for performing selective cell lysis, comprising: (a) obtaining a biological sample comprising a plurality of cells comprising a first population of cells originating from a subject of a first species and a second population of cells not originating from the subject; (b) isolating the cells from the biological sample; (c) contacting the cells with a permeabilization agent to (i) permeabilize at least about 90% of the first population of cells to produce permeabilized cells and (ii) permeabilize no more than about 10% of the second population of cells, thereby producing a cell suspension; (d) contacting the cell suspension with an amount of a deoxyribonucleic acid (DNA)-intercalating agent sufficient to produce at least about a 3-fold molar excess as compared to an amount sufficient to inhibit DNA extraction or amplification of the permeabilized cells; and (e) isolating the second population of cells from the cell suspension.
Patent WO-2021076314-A1 (WO)
Inventor: SCHWEITZER III
IPC: G01R31/12
Filed: 2020-09-29
Abstract: The present disclosure pertains to systems and methods for monitoring electrical arc events in an electric power system. In one embodiment, a system may comprise an arc flash detection (AFD) unit to detect electromagnetic radiation generated by an electrical arc event, a primary protection relay to generate measurements of an electric current, and an integrator. In various embodiments, the integrator may comprise a communication port to receive the detection of the electrical arc event and the measurements of the electric current. The integrator may also comprise a processing subsystem to validate the detection of the electrical arc and generate protective actions to interrupt the flow of the current to the electrical arc event.
Patent WO-2021067520-A1 (WO)
Inventor: GRANT ELLIOTT
IPC: A01B41/00
Filed: 2020-10-01
Abstract: Implementations are described herein for analyzing vision data depicting undesirable plants such as weeds to detect various attribute(s). The detected attribute(s) of a particular undesirable plant may then be used to select, from a plurality of available candidate remediation techniques, the most suitable remediation technique to eradicate or otherwise eliminate the undesirable plants.
Patent WO-2022075997-A1 (WO)
Inventor: KORNILOVICH PAVEL
IPC: G05D16/20
Filed: 2020-10-09
Abstract: L'invention concerne un dispositif à micro-soupape réversible comprenant un canal principal, un passage comprenant une ouverture en communication fluidique avec le canal principal, et une chambre latérale pour loger un volume de gaz piégé. La chambre latérale est reliée en communication au passage pour réguler l'écoulement le long du canal principal. La chambre latérale doit être plus grande en volume que le canal principal vers lequel le gaz piégé se dilate et comprend l'un des deux états suivants à un moment donné : un état ouvert dans lequel le canal principal est ouvert et l'écoulement se poursuit à travers le canal principal ou un état fermé dans lequel le gaz piégé à l'intérieur de la chambre latérale doit se dilater à l'intérieur du passage et bloquer l'écoulement dans le canal principal.
Patent WO-2021087431-A1 (WO)
Title: Gold nanoparticles/nanoshells immune conjugates for enhanced immunotherapy and photothermal therapy for hematologic malignancies
Inventor: LIN ADAM
IPC: C07H21/00
Filed: 2020-11-02
Abstract: Disclosed herein are CpG conjugated nanoparticles for immunotherapy and photothermal therapy. The composition comprises class B CpG conjugated nanoparticles and/or a class C CpG conjugated nanoparticles where the class B CpG conjugated nanoparticles comprises a nanoparticle core and a class B CpG conjugated thereto and the class C CpG conjugated nanoparticles comprises a nanoparticle core and a class C CpG conjugated thereto.
Patent WO-2021091879-A1 (WO)
Inventor: FAKIR RAHUL
IPC: C12M3/00
Filed: 2020-11-03
Abstract: The present disclosure is directed towards systems and methods for controlling three- dimensional bioprinters. In some embodiments, a server system may provide a user interface that can be used by a user may able to provide three-dimensional bioprinter specifications. The server system may then be configured to generate command instructions compatible with a particular bioprinter and then transmit the command instructions to the indicated bioprinter. In some embodiments the disclosed systems and methods may eliminate the need for downloading drivers or bioprinter specific software onto a user computing device. In some embodiments the disclosed systems and methods may be configured for use in restricted internet access settings.
Patent WO-2021113222-A1 (WO)
Inventor: HOLCOMB RYAN CHRISTOPHER
IPC: E21B43/12
Filed: 2020-12-01
Abstract: A system and method for cleaning a wellbore. The system includes a production device and a cleaning assembly coupled to a bottom end of the production device. The production device and cleaning assembly are conveyed to a target location in the wellbore. The cleaning assembly is activated to clean the wellbore with the production device disposed at the target location.
Patent WO-2021133988-A1 (WO)
Inventor: MANIPATRUNI SASIKANTH
IPC: H03K19/094
Filed: 2020-12-23
Abstract: An adder uses with first and second majority gates. For a 1-bit adder, output from a 3-input majority gate is inverted and input two times to a 5 -input majority gate. Other inputs to the 5-input majority gate are the same as those of the 3 -input majority gate. The output of the 5 -input majority gate is a sum while the output of the 3-input majority gate is the carry. Multiple 1-bit adders are concatenated to form an N-bit adder. The input signals to the majority gates can be analog, digital, or a combination of them, which are driven to first terminals of non- ferroelectric capacitors. The second terminals of the non-ferroelectric capacitors are coupled to form a majority node. Majority function of the input signals occurs on this node. The majority node is then coupled to a first terminal of a non-linear polar capacitor. The second terminal of the capacitor provides the output of the logic gate.
Patent WO-2021127685-A1 (WO)
Title: On-chip localization microscopy
Inventor: EVANS GERAINT
IPC: C12Q1/6827
Filed: 2020-12-08
Abstract: An analysis substrate comprises: a localization layer to be provided with a sample comprising a nucleotide provided with a fluorescent dye; and a sensor layer comprising an array of sensor pixels, the localization layer being on-chip relative to the sensor layer, one or more of the array of sensor pixels to receive a propagation of fluorescence from the fluorescent dye.
Patent WO-2021141849-A1 (WO)
Title: Patient-specific medical procedures and devices, and associated systems and methods
Inventor: CASEY NIALL PATRICK
IPC: A61F2/00
Filed: 2021-01-04
Abstract: Systems and methods for designing and implementing patient-specific surgical procedures and/or medical devices are disclosed. In some embodiments, a method includes receiving a patient data set of a patient. The patient data set is compared to a plurality of reference patient data sets, wherein each of the plurality of reference patient data sets is associated with a corresponding reference patient. A subset of the plurality of reference patient data sets is selected based, at least partly, on similarity to the patient data set and treatment outcome of the corresponding reference patient. Based on the selected subset, at least one surgical procedure or medical device design for treating the patient is generated.
Patent WO-2021162812-A1 (WO)
Title: Water disinfecting module, systems and methods
Inventor: PUGH STEVEN
IPC: C02F1/00
Filed: 2021-01-12
Abstract: Water disinfecting modules, water supply systems, methods of assembling a water supply system as well as method of disinfecting water are provided. The water disinfecting module includes a frame, hot and cold water flow switches and hot and cold UV treatment modules is provided. The frame supports a hot and cold water inlets and hot and cold water outlets. Hot and cold water flow switches are fluidly interposed between the respective inlets and outlets for sensing water flow. Hot and cold water UV treatment modules are fluidly interposed between corresponding inlets and outlets and are coupled to flow switches for activation upon sensing of water flow. All of the components are supported by the frame to form a complete unit. The systems and methods incorporate the use of such a water disinfecting module.
Patent WO-2021150756-A1 (WO)
Title: Inhibitors of glutathione s-transferases (gsts) and nad(p)h:quinone oxidoreductase 1 (nqo1), pharmaceutical compositions, and uses in managing cancer
Inventor: YE KEQIANG
IPC: A61K31/426
Filed: 2021-01-21
Abstract: This disclosure relates to compounds that inhibit glutathione S-transferases (GSTs) and/or NAD(P)H:quinone oxidoreductase 1 (NQO1) for uses in treating cancer. In certain embodiments, this disclosure relates to compositions and uses of N-(thiazol-2-yl)-carboxamide derivatives such as a N-(5-nitrothiazol-2-yl)-carboxamide derivatives for treating cancer such as glioblastoma. In certain embodiments, this disclosure relates to pharmaceutical compositions comprising a N-(thiazol-2-yl)-carboxamide derivative such as a N-(5-nitrothiazol-2-yl)-carboxamide derivative which is a compound of formula (I), or derivative, prodrug or salt thereof and a pharmaceutically acceptable excipient, wherein X, R 1 , R 2 , and R 3  substituents are reported herein.
Patent WO-2021155180-A1 (WO)
Title: Combinations of egfr inhibitors and ror1 inhibitors for the treatment of cancer
Inventor: KAUFMANN GUNNAR
IPC: C07K16/30
Filed: 2021-01-29
Abstract: Described herein is a method of treating a cancer in an individual comprising administering a tyrosine kinase-like orphan receptor 1 (ROR1) antagonist and an epidermal growth factor receptor (EGFR) inhibitor. In some embodiments, the ROR1 antagonist is cirmtuzumab. In some embodiments, the EGFR inhibitor is osimertinib. In some embodiments, the cancer is a lung cancer such as a non-small cell lung cancer.
Patent WO-2021247091-A1 (WO)
Inventor: MUTHIAH RAMANATHAN
IPC: G06F3/06
Filed: 2021-02-02
Abstract: A storage system and method for using proactive device timeout information are provided. In one embodiment, a storage system is provided comprising a memory and a controller. The controller is configured to receive a command from a host; determine whether the command can be executed within a time-out window; and in response to determining that the command cannot be executed within the time-out window, send a request to the host to extend the time-out window. Other embodiments are provided.
Patent WO-2021163223-A1 (WO)
Title: Using resilient systems inference for estimating hospital acquired infection prevention infrastructure performance
Inventor: PLATT LISA
IPC: A61B5/00
Filed: 2021-02-10
Abstract: The Resilience Inference System for Performance Safety (RISPS) Process Model is an algorithmic framework meant to enable healthcare organizations to forecast potential outcomes of operationally based infection control interventions in acute care settings. The RISPS Process Model projects operational performance safety outcomes based on the intersection of data driven possibilistic metrics of infection prevention risk and autonomous system adaptive response (i.e., resilience). Its purpose for continued use is to enable healthcare quality and safety teams to gain meaningful and accurate insight into the possible performance safety level of environment of care infection prevention strategies through the application of a series of System Science derived mathematical models.
Patent WO-2021183845-A1 (WO)
Title: Materials and methods for modulating delta chain mediated immunity
Inventor: GANESAN RAJKUMAR
IPC: C07K16/30
Filed: 2021-03-12
Abstract: Anti-TRDV2 multispecific antibodies or antigen binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.
Patent WO-2021183915-A1 (WO)
Title: Apparatuses and methods involving amplification circuit with push-pull wave-shaping operation
Inventor: RIVAS-DAVILA JUAN
IPC: H03K7/08
Filed: 2021-03-12
Abstract: In certain examples, methods and semiconductor structures are directed to circuit-based apparatus in which an amplifier includes stacked, first and second circuit amplification stages to operate out of phase from one another for providing a push-pull operation, with each of the first and second circuit stages including a switching circuit and an impedance path to drive the switching circuit. The apparatus further includes a waveform-shaping circuit to shape, in response to each of the first and second circuit stages, a voltage signal for presentation to the switching circuit. As may be implemented in various more-specific examples, the apparatus may generate a constant output voltage with high efficiency across a wide range of resistive loads.
Patent WO-2021183984-A1 (WO)
Title: Personal protection system and method
Inventor: GREEN LAWRENCE J
IPC: A63B71/10
Filed: 2021-03-13
Abstract: A protective headgear system includes a support configured to engage the head of a user, a facial shield having an upper portion coupled to the support and a lower portion having a lower extremity, a flexible sheet coupled to the facial shield, a base carried by the support, a first microphone carried below the lower extremity of the facial shield and preferentially oriented away from the user, a second microphone carried by the base and preferentially oriented toward the user, a first audio generator capable of being sensed by at least one ear of the user, and a second audio generator including a loudspeaker carried by the base such that the loudspeaker is located below the lower extremity of the facial shield and is oriented for preferential sound energy delivery generally away from the user.
Patent WO-2021184005-A1 (WO)
Title: Ultrasound imaging systems and methods
Inventor: JAMELLO JOSEPH
IPC: A61B8/08
Filed: 2021-03-15
Abstract: An ultrasound imaging system includes an ultrasound transducer array having a plurality of transducer element and a catheter having one or more transmission lines programmably connected to the plurality of transducer elements. The programmable connection between the transmission lines and the plurality of transducer elements defines a synthetic aperture size. The ultrasound imaging system acquires images using an initial synthetic aperture size, detects a relative motion of a target of interest in the acquired images, and adjusts the synthetic aperture size based on the detected relative motion.
Patent WO-2021188666-A1 (WO)
Title: Composition, system, and method for automatic dosing of a urinal cleaner
Inventor: EVERETT GABRIEL
IPC: C11D11/00
Filed: 2021-03-17
Abstract: A urinal and pipe cleaning composition and automated dispensing system and method. The composition preferably comprises urea hydrochloride, a thickener, optionally one or more surfactants, and optionally fragrance. Preferably, the surfactants comprise cocamidopropyl betaine and one or more ethoxylated alcohols. The composition preferably has a viscosity allowing it to be dispensed from an automated dispenser and to coat the surfaces to be cleaned to allow sufficient contact time to dissolve accumulated salts and remove stains. A predetermined dose of the composition is dispensed at predetermined time intervals. Different dose amounts and time intervals may be used depending on the level of usage of the urinal, the amount of salt scale, and level of staining.
Patent WO-2021195245-A1 (WO)
Title: Compositions antimicrobiennes contenant du carboxyméthylène de polyphénylène
Inventor: NORTH BARBARA
IPC: A01N33/04
Filed: 2021-03-24
Abstract: Dans un mode de réalisation, la présente invention concerne un procédé pour réduire au maximum l'infectivité et la réplication d'une infection ou réduire une inflammation provoquée par l'infection. De manière générale, le procédé comprend l'administration d'une composition à un sujet, la composition comprenant un polymère de condensation. Dans certains modes de réalisation, le procédé comprend en outre la liaison, par la composition, à un site sur un virus, des bactéries ou des champignons associés à l'infection pour ainsi inhiber la réplication du virus, des bactéries ou des champignons et/ou la réduction, par la composition, d'une inflammation liée à l'infection. Dans un autre mode de réalisation, la présente invention concerne un procédé pour réduire au maximum l'infectivité et la réplication d'un pathogène. De manière générale, le procédé comprend l'application d'une composition sur un vêtement, la composition comprenant un polymère de condensation.
Patent WO-2021221910-A1 (WO)
Inventor: DE ANGELIS GILBERT
IPC: C03B17/06
Filed: 2021-04-14
Abstract: Disclosed are various methods and apparatus for forming sheet glass from molten glass whose liquidus viscosity is < 5 kP. Also disclosed is a roller for receiving and cooling continuously-fed ribbon of glass whose liquidus viscosity is < 5 kP onto the roller's outer surface, where the roller is configured to be maintained at a predetermined temperature and can be rotated at a predetermined speed so that the glass ribbon comes in contact with the roller for a set duration of time and rolls off the roller at the end of the set duration of time.
Patent WO-2021236402-A1 (WO)
Title: Dynamic multiphase injection-locked phase rotator for electro-optical transceiver
Inventor: ZHANG YUDONG
IPC: H03K3/03
Filed: 2021-05-13
Abstract: Presented herein are methodologies for generating clock signals for transceivers that rely on frequency and phase error correction functions. The methodology includes generating a differential clock signal at a fundamental frequency, generating, based on the differential clock signal and using a multiphase generator, four quadrature signals at the fundamental frequency, supplying the four quadrature signals to an injection-locked phase rotator, and outputting, from the injection-locked phase rotator, a phase adjusted multiphase clock signal based on the four quadrature signals.
Patent WO-2022031339-A1 (WO)
Title: Cryptography using varying sized symbol sets
Inventor: HASSAN AMER AREF
IPC: H04L9/16
Filed: 2021-05-13
Abstract: Disclosed are systems, methods, and non-transitory computer-readable media for symmetric cryptography using varying sized symbol sets. To protect against a brute force or other similar type of attack, multiple symbol sets of varying sizes can be used for encrypting/ decrypting data. For example, different portions of the data (e.g., data blocks representing multiple symbols, set of bits representing a single symbol) may be encrypted/ decrypted using different symbol sets that include different numbers of unique symbols. Using varying sized symbol sets adds additional complexity to the encryption process, thereby greatly increasing the difficulty in decrypting the encrypted data with a brute force attack.
Patent WO-2021231872-A1 (WO)
Title: Compositions and methods for increasing efficacy of a drug
Inventor: BAVARI SINA
IPC: A61K41/00
Filed: 2021-05-14
Abstract: The present disclosure relates to a composition and method for enhancing a drug's efficacy by combining the drug with a mammalian protease inhibitor such as a cathepsin inhibitor. Methods for using the combination of the disclosure for treatment of disease are described.
Patent WO-2022026192-A1 (WO)
Inventor: ISLA GARCIA JULIO
IPC: A61B5/1455
Filed: 2021-07-14
Abstract: A system for measuring an analyte within a cerebral venous blood flow is provided. The system includes an excitation light source, a light delivery element, an ultrasound receiving mechanism, and a controller. The excitation light source is configured to produce one or more wavelengths operable to cause an analyte to photo acou Stic ally produce at least one ultrasonic signal. The light delivery element is disposed on a posterior region of a human head, and receives light from the light source. The ultrasound receiving mechanism is disposed on an anterior region of the head. The mechanism includes at least one ultrasonic receiver. The controller is configured to control the excitation light source to selectively produce the excitation light, and to measure an amount of the analyte present within the cerebral venous blood flow.
Patent WO-2022026657-A1 (WO)
Inventor: ZHANG XUAN
IPC: C07C231/12
Filed: 2021-07-29
Abstract: Compositions that include cationic surfactants and methods of synthesizing compositions that include cationic surfactants. The surfactants include a quaternary amine and a saturated or unsaturated alkyl chain with 4 to 28 carbons. The surfactants can be generated by reacting a fatty acid modified with an amino alkyl group and an epihalohydrin in the presence of a base. The cationic surfactants can be generated by reacting a fatty acid modified with an amino alkyl group, an epihalohydrin, and a carboxylic acid. The cationic surfactants can be generated by reacting a carboxylic acid, an epihalohydrin, and a catalyst to afford a halo-substituted alkyl ester, followed by reacting the halo-substituted alky ester with a fatty acid modified with an amino alkyl group.
Patent WO-2022026742-A1 (WO)
Inventor: GOPALAN MANOJ
IPC: E21B17/07
Filed: 2021-07-29
Abstract: A shock isolator device for use in a downhole tool attenuates axial shocks to a protected structure and maintains that structure's rotational orientation to the tool while reducing damage to, maintenance costs of, and wear on, the device components. The shock isolator device interposes an internally- and externally-splined key between an internally-splined sleeve on an anti-rotation section and an externally-splined plunger attached to a connector. The key is less wear-resistant than the sleeve or plunger and can be replaced. The meshed sleeve, key, and plunger force the protected structure attached to the connector to maintain its rotational orientation. The sleeve of the anti-rotation system is attached to a shock damper, which damps axial shocks between the plunger and the sleeve, and is connected to a second connector. The shock damper includes a spring assembly and a viscous damper using a piston in an oil-filled cylinder forcing oil through an orifice.
Patent WO-2022031535-A1 (WO)
Title: Insulated trench gates with dopants implanted through gate oxide
Inventor: MOORE PAUL M
IPC: H01L29/78
Filed: 2021-07-30
Abstract: In an insulated trench gate device, polysilicon in the trench is etched below the top surface of the trench, leaving a thin gate oxide layer exposed near the top of the trench. An angled implant is conducted that implants dopants through the exposed gate oxide and into the side of the trench. If the implanted dopants are n-type, this technique may be used to extend an n+ source region to be below the top of the polysilicon in the trench. If the implanted dopants are p-type, the dopants may be used to form a p-MOS device that turns on when the polysilicon is biased with a negative voltage. P-MOS and n-MOS devices can be formed in a single cell using this technique, where turning on the n-MOS device turns on a vertical power switch, and turning on the p-MOS device turns off the power switch.
Patent WO-2022031882-A1 (WO)
Title: Il-8 antibodies and methods of use thereof
Inventor: PAZ KEREN
IPC: C07K16/42
Filed: 2021-08-05
Abstract: Described herein are anti-IL-8 antibodies, compositions thereof, and methods of use thereof. The anti-IL-8 antibodies would be useful in methods of inhibiting tumor formation or growth or a combination thereof. Described herein are also methods of using the anti-IL-8 antibodies for methods of treating a disease, wherein diseases may include cancer, a tumor, or a viral infection.