baber/WOPTO huggingface dataset:
Patent EP-0340247-B1 (EP)
IPC: C07B57/00
Filed: 1988-03-11
Granted: 1993-04-28
Abstract: PCT No. PCT/DE88/00149 Sec. 371 Date Nov. 13, 1989 Sec. 102(e) Date Nov. 13, 1989 PCT Filed Mar. 11, 1988 PCT Pub. No. WO88/07050 PCT Pub. Date Sep. 22, 1988.The invention relates to a process for the production of (+)-bicyclo[3.3.0]octan-3-one-2 carboxylic acid steroid esters of formula I   <IMAGE> (I)  in which X means oxygen or the radicals -O-(CH2)n-O- or -O-CH2-C(CH3)2-CH2-O-, n means 2 or 3 R2 means hydrogen or methyl, Y means the radicals X or X1, X1 means the radicals OCH3 or OCOR3, R3 means methyl, ethyl, phenyl, benzyl or pivalyl and the radical   <IMAGE>  the radicals  <IMAGE>  <IMAGE> and X and X1 have the meanings indicated above, characterized in that D,L-bicyclo[3.3.0]octan-3-one-2 carboxylic acid esters of formula II <IMAGE> (II)  in which X has the meaning indicated above and R is an alkyl group with 1-4 carbon atoms, with optically active steroids with a free 17'beta hydroxy group of formula III    <IMAGE> (III)  in which R2 and the radical   <IMAGE>  have the meanings indicated above, in the presence of a nucleophilic or acid catalyst is converted into the diastereomeric steroid esters and the optically pure steroid esters of formula I are obtained as crystallizates.
Patent EP-0305491-B1 (EP)
Inventor: LEDIS STEPHEN L
IPC: G01N33/50
Filed: 1988-03-11
Granted: 1996-02-07
Abstract: A method and reagent system for the rapid isolation, identification, and/or analysis of leukocytes from a whole blood sample. The reagent system includes a lytic reagent solution comprising an aqueous solution of a water soluble compound which at least partially dissociates in aqueous solution to release a proton and a counterion and which, upon contact with a blood sample, acidifies the sample to a pH in the range of from about 2.6 to 4.0. The reagent system also includes a quenching reagent solution comprising an aqueous alkaline salt solution which effectively and rapidly arrests the chemical action of the lytic reagent solution on the sample and restores the native physiological environment of the sample. The method comprises using the reagent system to selectively lyse the red blood cells in a blood sample and modify the leukocytes to enable their differentiation into five sub-populations.
Patent EP-0311694-B1 (EP)
Inventor: KUZUHARA HIROYOSHI
IPC: C07H19/16
Filed: 1988-04-22
Granted: 1995-12-13
Abstract: L'invention porte sur des dérivés de didésoxynucléosides ayant une action antivirale, des intermédiaires pour leur synthèse et le procédé de synthèse de ceux-ci. Le procédé en question est caractérisé par l'introduction sélective d'un groupe mésyle, toxyle ou trifluorométhanesulfonyle en position 3' d'un élément ribose de divers nucléosides dont la base et les positions 2' et 5' de l'élément ribose sont protégées, le produit étant traité par une base et un réducteur pour donner un intermédiaire qui permet la synthèse des dérivés des dinucléosides. Ce procédé permet de préparer plusieurs nouveaux intermédiaires et dérivés de didésoxynucléosides. L'invention porte également sur un autre procédé de synthèse d'intermédiaires, qui permet de synthétiser des dérivés de didésoxynucléosides. Ce procédé consiste à faire réagir un dérivé de nucléoside dont la base et les positions 2' et 5' de l'élément ribose sont protégées par des groupes pivaloyle et la position 3' par un groupe mésyl, tosyl ou trifluorométhanesulfonyle avec un composé alcalin pour éliminer sélectivement les groupes pivaloyle de labase.
Patent EP-0357668-B1 (EP)
IPC: G01N15/06
Filed: 1988-05-16
Granted: 1991-09-04
Abstract: Afin d'obtenir des mesures extrêmement précises par un procédé indépendant de la teneur en suie des gaz de fumée, on détermine au moyen d'un algorythme approprié le volume de gaz de fumée duquel dérive la charge du filtre à partir de la valeur du noircissement du filtre calculée lors d'un test précédent. On recommence l'échantillonnage uniquement lorsque le noircissement du filtre n'est pas compris dans une plage spécifique.
Patent EP-0328663-B1 (EP)
Inventor: FUJITA NAOKI DAI- -KOHPO
IPC: G05B19/18
Filed: 1988-07-20
Granted: 1994-12-28
Abstract: In a method of replacing tools of the invention, a first NC program (NCP1) is prepared in an integral form containing instructions (ATC1 to ATC3) for automatically selecting a tool, to be used for each of the steps (MP1 to MP3) and the machining instructions (MC1 to MC3) for the tools, and the first NC program (NCP1) is stored in a memory of an NC apparatus. Then, the first NC program (NCP1) is converted into a second NC program (NCP2) having an instruction MO6TETAETAETA, DELTADELTADELTA (PTCM1 to PTCM3) which holds the tool to be used in the next step at a stand-by position. Then, the NC apparatus executes the numerical control based on the second NC program (NCP2). That is, the NC apparatus supplies the machine side with the tool number DELTADELTADELTA that has been read out for the next step prior to effecting the machining instruction (MC1 to MC3) for the present step so as to cause the automatic tool exchanger to carry a tool for the next step to the stand-by position, while operating the machining based on the machining instruction of the present step.
Patent EP-0344532-B1 (EP)
Inventor: JEKAT HERBERT DIPL-ING DR
IPC: F16J15/32
Filed: 1989-05-18
Granted: 1994-07-13
Abstract: The invention relates to a sealing device of the bearings of a rotating shaft with its associated drive unit on agitator mechanisms or pump impellers which treat aggressive, explosive, radioactive or toxic media or solid suspensions. On the product side, an axial face seal is arranged between the agitator shaft and the housing of the agitator mechanism, whilst on the drive side a static hermetically sealing sealing element is installed between the shaft and the drive unit on the one hand and the housing on the other hand. The interior of the housing in which the bearings are installed is filled with a lubricant which is maintained at a pressure equal to or above the pressure in the product container. 
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Patent EP-0351764-B1 (EP)
IPC: E05D5/10
Filed: 1989-07-18
Granted: 1992-10-28
Abstract: The present invention relates to a male element for hinges of door and window frames or the like, composed of a cylindrical body (2) from which a rotation pivot (3) axially extends. The male element is axially provided with a first hole (4) in which a dowel (5) is inserted; the dowel has a substantially hemispherical end (6) which protrudes from the pivot. The body is axially provided with a second hole (7) in which the fork-like end (9) of a threaded fixing stem (10) is inserted so as to embrace the dowel. The bottom (8) of the second hole is shaped so as to provide the plastic deformation of the fork (9) when it is inserted, stably fixing it to the dowel and/or to the body.
Patent EP-0365835-B1 (EP)
Inventor: WICKLI WERNER
IPC: B32B27/20
Filed: 1989-09-23
Granted: 1996-04-24
Abstract: The synthetic article, designed for example as a tube, has an inner layer (l), for example of HDPE (high density polyethylene) and an outer layer (4) of the same HDPE. The middle layer, coextruded with the layers mentioned consists of a thermoplastically workable, synthetic elastomer, which is provided with a filler (3) of barium sulphate. Consequently, the middle layer (2,3) has a higher density and elasticity than the two outer layers (1,4). This produces an excellent soundproofing effect. Due to the choice of the said materials, there is the possibility of producing such a tube in one operation by coextrusion, so that a subsequent application or attachment of such a soundproofing layer is no longer necessary. For thermal insulation, a blowing agent may also be added to the material which is used for forming the inner layer (2), before extrusion, so that the pores formed thereby additionally provide a thermal insulating effect. The plastic tube is intended in particular for installation in residential and industrial structures. <IMAGE>
Patent EP-0422281-B1 (EP)
IPC: F16L59/02
Filed: 1989-10-13
Granted: 1996-08-14
Abstract: A method of making high efficiency, flame resistant polyimide foam insulation particularly suitable for insulating plastic pipes and forming ducts. Typically, a sheet of polyimide foam which has been foamed unconstrained is placed between opposed caul plates, squeezed to a thickness less than the original thickness and heated to stabilize the new sheet thickness. Face sheets coated with a polyimide adhesive can then be placed against the stabilized foam faces and heated between plates to bond the face sheets to the foam. Also, a sheet of foam which had been impregnated with polyimide resin precursor can be placed against the stabilized sheet and the resin precursor simultaneously cured and the sheet bonded to the stabilized foam. A variety of flat, tubular or other shapes can be made by this method. The resulting insulation panels, tubes or the like have greatly improved flame resistance and excellent thermal insulation characteristics.
Patent EP-0359347-B1 (EP)
Title: Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
IPC: A61K47/42
Filed: 1989-08-14
Granted: 1992-12-23
Abstract: Covalently-linked complexes (CLCs) for targeting a defined population of cells, comprising a targeting protein; a cytotoxic agent; and an enhancing moiety, wherein the enhancing moiety is capable of promoting CLC-target cell interaction are disclosed. Methods for using the claimed CLCs to obtain enhanced in vivo cytotoxicity and enhanced in vivo imaging are also described.
Patent EP-0336587-B1 (EP)
Title: Fluoroalkoxy amino triazines for control of weeds in sugar beets
IPC: A01N47/36
Filed: 1989-03-16
Granted: 1993-08-11
Abstract: Compounds of the formula <CHEM>  wherein R is C1-C4 alkyl, CH2CH=CH2, CH2C IDENTICAL CH, cyclopropylmethyl or CH2CH2R2; R1 is C1-C2 alkyl, C1-C2 haloalkyl, CH2CN, CH2OCH3, C1-C3 alkoxy, C1-C3 alkylthio, phenylthio or NR3R4;  R2 is C1-C2 alkoxy, C1-C2 alkylthio, CN or halogen;  R3 and R4 are independently H or CH3; and  X is NHCH3, N(CH3)2 or N(CH3)OCH3; provided that when R1 is OCH2CH3 or CH2OCH3, then R is other than CH3; and their agriculturally suitable salts. exhibit herbicidal activity. They have particular utility for the selective control of weeds in beet.
Patent EP-0345996-B1 (EP)
Inventor: TRELFORD A
IPC: H05K5/00
Filed: 1989-06-01
Granted: 1994-02-09
Abstract: The present invention relates to an instrument case including two side panels (10, 11) arranged to mate with a further panel (12) to be supported substantially parallel thereby and a member (20) adapted to interlock in a plane normal thereto with both side members to brace the side members. The side panels (10, 11) the further panels and the member (20) provide a self supporting structure. The case may be completed by the addition of further panels. The case constitutes a support (52, 53) and enclosure for circuit boards, the member (20) forming a motherboard (40) which may act as a case divider. The invention solves the problem of providing a circuitboard support and mother board (40) without recourse to additional components and a card frame with its consequent weight penalty.
Patent EP-0351138-B1 (EP)
Inventor: TABOR STANLEY
IPC: C12Q1/68
Filed: 1989-07-06
Granted: 1995-03-08
Abstract: A method for sequencing a strand of DNA, including the steps of: providing the strand of DNA; annealing the strand with a primer able to hybridize to the strand to give an annealed mixture; incubating the mixture with a deoxyribonucleoside triphosphate, a DNA polymerase, and a chain terminating agent under conditions in which the polymerase causes the primer to be elongated to form a series of DNA products differing in length of the elongated primer, each DNA product having a chain terminating agent at its elongated end; the number of each DNA product being approximately the same for substantially all DNA products differing in length from 1 to 20 bases.
Patent EP-0370676-B1 (EP)
Inventor: FILHOL STUART JULIAN
IPC: A61C13/30
Filed: 1989-11-14
Granted: 1995-01-25
Abstract: A dental post 5 has a lower portion 4 that is fitted within a pre-prepared dental root canal 2, 3 and an upper portion 6 to which a dental crown 8 can be fitted. The root canal is provided with a plurality of projections 26 that extend downwardly and inwardly and the post, which is preferably tapered, and the lower portion of the post has a plurality of notches 16 that are preferably independent grooves that face upwardly. The post can then be secured substantially without screwing, by means of cement in the annulus 7 between the post and the canal. Preferably the lower portion of the post is tapered and has grooves or other notches that open upwardly and outwardly and the upper portion has grooves that open downwardly. The pitch of the grooves 16 in the lower portion is generally not more than 0.5mm. The invention also includes a dental reamer that can be used to form a profiled cavity in a tooth and that has an elongated cutting head (30, 31, 32) having a plurality of cutting elements (34) that can be used for cutting into the wall of the canal to define the projections 26.
Patent EP-0393116-B1 (EP)
Title: Servo pattern
Inventor: BIZJAK JOHN F
IPC: G11B5/596
Filed: 1988-10-28
Granted: 1996-01-17
Abstract: The present invention describes a time based servo pattern scheme which provides position and velocity information with high accuracy. A plurality of servo lines are formed on a data disk extending from the inner track to the outer track, In the preferred embodiment of the present invention, these lines are employed as part of a buried servo scheme such that the entire useable disk surface is dedicated to data storage. The servo pattern is written on each side of the disk so that, if the disk were transparent, the respective servo lines would appear to intersect when viewed from above. Servo heads located on each side of the disk detect servo line crossings. By comparing the time difference between crossings of corresponding tracks on either side of the disk, the radial position of the heads can be determined. Therefore, even when nominal track centers do not fall on servo line intersections, their position can be determined accurately. Thus, the servo pattern of the present invention is track pitch independent. A concentric calibration track is formed on the disk surface so that offsets between the desired servo and data head positions may be detected and compensated.
Patent EP-0402365-B1 (EP)
IPC: B29C35/04
Filed: 1989-01-23
Granted: 1992-09-09
Abstract: L'appareil décrit, qui sert à la vulcanisation de goulottes ou cheminées isolantes, comprend un moule en deux parties (1, 2), une partie mâle (1) et une partie femelle (2). Le bord d'attaque (5) de la partie mâle (1) vient se placer en contact avec la surface interne (6) de la partie femelle (2) et glisse le long de cette surface avant d'entrer en contact avec la préforme (4) de la goulotte ou cheminée isolantes qui est placée dans le moule. Le but est d'empêcher que la laine minérale se répande hors du moule en sortant par l'espace entre les deux moitiés du moule.
Patent EP-0345345-B1 (EP)
IPC: A61F2/02
Filed: 1988-12-01
Granted: 1991-10-09
Abstract: Un transducteur électro-acoustique, par exemple un appareil pour sourds ou un récepteur de signaux de haute fréquence, se loge entièrement dans une cavité chirurgicalement ménagée dans les os adjacents à l'oreille, ce qui fait que l'appareil est complètement invisible. De préférence, un accumulateur rechargeable est implanté en même temps que le transducteur électro-acoustique. Le transducteur peut comprendre un tube au moyen duquel il peut régler l'amplificateur, effectuer d'autres réglages éventuels ou charger l'unité d'alimentation, par exemple.
Patent EP-0394455-B1 (EP)
Inventor: MATSUNO HIDETOSHI NKK CORPORAT
IPC: C22C33/04
Filed: 1989-04-04
Granted: 1994-03-16
Abstract: Un procédé pour produire un alliage de fer-bore-silicium par l'intermédiaire d'étapes simples et de manière économique, consiste à ajouter une substance borée et un agent réducteur carboné à du fer en fusion placé dans un récipient, à insuffler de l'oxygène dans ledit fer en fusion afin d'y réduire la substance borée et de préparer un métal en fusion contenant du bore, à continuer à insuffler de l'oxygène jusqu'à ce que la teneur en carbone du métal en fusion renfermant du bore atteigne 0.2 % en poids au maximum afin de décarburer le fer en fusion contenant du bore, et à ajouter à ce dernier au moins un composé parmi le silicium et le ferrosilicium.
Patent EP-0374257-B1 (EP)
Inventor: HARA MICHIO
IPC: A61K47/14
Filed: 1989-05-02
Granted: 1994-08-31
Abstract: A stable interferon  beta  composition is disclosed, which contains 65 to 90 wt % of polyol and a p-hydroxybenzoate. This composition can be stored for a long time at room temperature and, even when various additives are incorporated therein, IFN  beta  will not be deactivated and the IFN  beta  stabilizing effect will last for a long time.
Patent EP-0444031-B1 (EP)
Inventor: NIEUWKAMP WOLFGANG
IPC: B05B9/00
Filed: 1989-05-23
Granted: 1994-01-05
Abstract: Appareil de nettoyage haute pression doté d'une pompe haute pression (2) pour liquide de nettoyage, qui est reliée du côté admission à un décanteur primaire (4), comprenant une conduite d'alimentation en liquide de nettoyage, et qui comporte sur la conduite de haute pression une conduite de dérivation (7) menant de la conduite de haute pression au décanteur primaire; ledit appareil de nettoyage haute pression est en outre doté d'un moteur électrique (1), qui entraîne la pompe haute pression (2) et qui comporte une conduite de liquide de refroidissement (11) où circule du liquide de nettoyage. Pour que le moteur électrique (1) soit refroidi de manière efficace même en mode de recyclage, sans perte de liquide de refroidissement, la conduite d'alimentation (13) du décanteur primaire a une capacité de débit supérieure à celle de la conduite de liquide de refroidissement (11), cette dernière débouchant dans le décanteur primaire (4), qui comporte des moyens de limitation du niveau de remplissage (15, 16, 17).
Patent EP-0419534-B1 (EP)
Inventor: ANTONIAOES HARRY N
IPC: A61K38/27
Filed: 1989-05-22
Granted: 1994-08-03
Abstract: Healing an external wound of a mammal by administering to the mammal a composition containing purified Insulin-like growth factor-1 and purified transforming growth factor beta.
Patent EP-0420924-B1 (EP)
Inventor: FREEMAN MICHAEL ASHLEY
IPC: B32B3/06
Filed: 1989-06-20
Granted: 1996-05-15
Abstract: A barrier, particularly to methane and radon, employs a barrier layer (10) (preferably aluminium) encapsulated in protective layers (14, 16) which are bonded to all of its surfaces and extend beyond its main edges where they are mutually bonded. The protective layers (14, 16) include at least one plastics layer. Typically there is a strengthening layer (14) e.g. of polyester coextrusive with the aluminium (10), the aluminium and polyester being encapsulated by a layer (16) of polyolefin on one face and another layer (16) of polyolefin and/or bitumen at the other face.
Patent EP-0407500-B1 (EP)
Inventor: LECON WOO
IPC: B29C65/74
Filed: 1989-10-10
Granted: 1993-12-15
Abstract: L'invention concerne un appareil (10) permettant de sceller une bande de film (16) dans une machine de conditionnement. Ledit appareil comprend une barre de scellement (18) destinée à chauffer une bande de film (16) à une température suffisante pour faire fondre au moins une partie de la bande de film. La barre de scellement (18) comprend une surface (19) venant directement au contact de la bande de film, et ne comporte pas de couche de libération. La surface est dotée d'un élément de mesure (30) destiné à mesurer la température de la surface fondue du film. Ledit appareil comprend en outre un élément de refroidissement (42) destiné à refroidir la partie fondue du film jusqu'à son point de cristallisation pendant un temps de cycle de la machine de conditionnement.
Patent EP-0392476-B1 (EP)
Inventor: WICHELHAUS JUERGEN DR
IPC: D06M15/693
Filed: 1990-04-10
Granted: 1994-07-06
Abstract: The processibility of polymer fibres, in particular aramid fibres, was to be improved. This became possible by using solutions or dispersions of resins in an organic solvent containing - 0.2 - 20% by weight of at least one polyamide resin based on long- chain branched dicarboxylic acids which has terminal carboxylic and/or amino groups, - 0.02 - 10% by weight of a compatible copolymer which contains carboxylic acid and/or anhydride groups and also carboxylic esters,,  - 0 - 5% by weight of further auxiliaries and also  - ad 100% by weight of organic solvent for the surface treatment of polymer fibres.
Patent EP-0406893-B1 (EP)
Inventor: RAMELLA LUCA
IPC: A61M15/00
Filed: 1990-07-06
Granted: 1993-11-24
Abstract: The device for the administration of inhalation medicament held in a capsule (C) comprises a chamber (18) adapted to receive a capsule (C) and provided with an air inlet and an air outlet, capsule piercing means (P) and a magazine (30,40) for holding a plurality of capsules (C). The magazine (30,40) is rotatably mounted about the air outlet and there are provided loading means (50) to convey a capsule (C) from the magazine (30,40) to the chamber (18).
Patent EP-0384514-B1 (EP)
Inventor: DANSEREAU RICHARD JOHN
IPC: A61K47/32
Filed: 1990-02-12
Granted: 1993-11-24
Abstract: The present invention provides a dual-action tablet composition comprising:   (a) an outer tablet comprising a first dose of active ingredient dispersed in a pH independent hydrophilic polymer matrix; and (b) an inner tablet comprising a second dose of active ingredient in a rapidly disintegrating excipient base.   This dual-action tablet is especially efficacious for those active ingredients which half lives of less than two hours and which experience decreased absorption efficiency in the lower gastrointestinal tract. Among the preferred dual-action tablet composition is one wherein the active ingredient in both the inner and outer tablets is guaifenesin. Upon administration, the outer tablet provides a controlled release of the active ingredient while the inner tablet gives a second dose of active ingredient after the outer tablet has partially dissolved.
Patent EP-0405844-B1 (EP)
Inventor: BRYANT STEWART FREDERICK
IPC: H04L12/56
Filed: 1990-06-21
Granted: 1996-08-28
Abstract: A known congestion avoidance system for computer networks detects congestion at a node output port if the average queue length (integral) over the last congestion cycle plus the current (incomplete) cycle exceeds a fixed constant (taken as 1). (A congestion cycle is a period for which the queue length is 1 or more plus the following period for which the queue length is 0.) The time of arrival or departure of a message is stored at 21, the interval from the previous event is calculated at 22 and 23, the length of the current cycle is incremented at 25 by adding in the interval just determined, and the queue length at 26 is incremented or decremented by 1. The running integral for the current cycle is updated by having added into it the product formed at 27 of the interval since the last event (stored at 23) and the current queue length. The integrals for the current and previous cycles (stored at 24 and 30) are added and the lengths of those two cycles (stored at 29 and 31) are added, and the first sum divided at 34 by the second to obtain a grand average queue length. If that exceeds a preset value, then a congestion bit is set in messages leaving that node output port. In the present system, the running queue length average (in 29 min ) is maintained by adding (at 28 min ) the queue length (in 26 min ) into the average at regular intervals determined by timer ticks (from 60) (thus using integer addition instead of integer multiplication), and the grand average compared with the preset value by comparing (at 61) the total of the queue length averages with the total of the cycle periods (thus using integer addition and comparison instead of floating point operation).