Patent SG-11201809089Q-A (SG)
Title: Bispecific binding proteins and uses thereof
Inventor: KASTURIRANGAN SRINATH
IPC: C07K16/46
Filed: 2017-05-05
Abstract: Ocr N O C () INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 09 November 2017 (09.11.2017) WIP0 I PCT omit VIII VIII lII 0 VIII moolllooloil (10) International Publication Number WO 2017/193032 A2 (51) International Patent Classification: A61K 47/48 (2006.01) A61K 39/395 (2006.01) (21) International Application Number: PCT/US2017/031356 (22) International Filing Date: 05 May 2017 (05.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/332,788 06 May 2016 (06.05.2016) US (71) Applicant: MEDIMMUNE, LLC [US/US]; One Medlm- mune Way, Gaithersburg, MD 20878 (US). (72) Inventors: KASTURIRANGAN, Srinath; c/o Medlm- mune, LLC, One Medlmmune Way, Gaithersburg, MD 20878 (US). GAO, Changshou; c/o Medlmmune, LLC, One MedImmune Way, Gaithersburg, MD 20878 (US). RAINEY, Godfrey; c/o Medlmmune, LLC, One Medlm- mune Way, Gaithersburg, MD 20878 (US). MORROW, Michelle; c/o MedImmune Limited, Milstein Building, Granta Park, Cambridge CB21 6GH (GB). DOBSON, Claire, Louise; c/o MedImmune Limited, Milstein Build- ing, Granta Park, Cambridge CB21 6GH (GB). DRABIC, Stacey; c/o MedImmune, LLC, One Medlmmune Way, Gaithersburg, MD 20878 (US). SCHOFIELD, Darren; c/ o Medlmmune Limited, Milstein Building, Granta Park, Cambridge CB21 6GH (GB). CARLESSO, Gianluca; c/ o Medlmmune Limited, Milstein Building, Granta Park, Cambridge CB21 6GH (GB). POLLIZZI, Kristen; c/o Medlmmune, LLC, One Medlmmune Way, Gaithersburg, MD 20878 (US). MAZOR, Yariv; c/o Medlmmune, LLC, One Medlmmune Way, Gaithersburg, MD 20878 (US). OBERST, Michael; c/o Medlmmune, LLC, One Medlm- mune Way, Gaithersburg, MD 20878 (US). HAMMOND, Scott, A.; c/o Medlmmune, LLC, One Medlmmune Way, Gaithersburg, MD 20878 (US). LOBO, Brian; c/o Medlm- mune, LLC, One Medlmmune Way, Gaithersburg, MD 20878 (US). MANIKWAR, Prakash; c/o Medlmmune, LLC, One Medlmmune Way, Gaithersburg, MD 20878 (US). SEAMAN, Jonathan; c/o Medlmmune Limited, Mil- stein Building, Granta Park, Cambridge CB21 6GH (GB). (74) Agent: MENSAH, Kwame, N. et al.; c/o Medlmmune, LLC, One Medlmmune Way, Gaithersburg, MD 20878 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (54) Title: BISPECIFIC BINDING PROTEINS AND USES THEREOF FIGURE 1 (57) : The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides for specific binding proteins, including antibodies, which bind to a target protein. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such proteins and methods of making such proteins. The disclosure provides methods of inducing an immune response in a subject as well as methods for treating or preventing cancer in a subject by administering the proteins, nucleic acid molecules and/or compositions to the subject. [Continued on next page] WO 2017/193032 A2111114E01I1010llilifilOMOM11111111 1111111IDIIE110IS DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — without international search report and to be republished upon receipt of that report (Rule 48.2(g)) — with sequence listing part of description (Rule 5.2(a))