baber/WOPTO huggingface dataset:
Patent RU-2728829-C1 (RU)
Title: New isoindoline derivative, pharmaceutical composition including thereof and use thereof
Inventor: LEE WEN-CHERNG
IPC: C07D209/49
Filed: 2018-02-27
Granted: 2020-07-31
Abstract: FIELD: medicine; pharmaceuticals. 
     SUBSTANCE: invention relates to a compound of formula I 
     
       
     
     or a pharmaceutically acceptable salt thereof, stereoisomer or isotopic compound, wherein a carbon atom marked with * represents a center of asymmetry; R1 and R2 independently represent H, R 6 -S(O) 2 -, or R 6 -C(O)-; R 6  is unsubstituted (C 3 )cycloalkyl; or (C 1 -C 6 )alkyl, which is optionally substituted with one or more groups selected from D, halogen, hydroxyl, amino, (C 1 -C 6 ) alkylamino, (C 1 -C 6 )alkoxy and benzyloxy; X 1 , X 2 , X 3 , X 4 , X 5  and X 6  independently represent CH, CR 7  or N; R 7  is halogen or cyano; R 3  and R 4  independently represent H, substituted or unsubstituted (C 1 -C 6 ) alkyl; R 5  is unsubstituted (C 1 -C 6 ) alkyl; R 10 , R 11  and R 12  independently represent H or D; substituent in the substituted (C 1 -C 6 ) alkyl is one or more selected from the group consisting of: D, halogen, hydroxyl, amino, (C 1 -C 6 ) alkylamino, (C 1 -C 6 ) alkoxy and benzyloxy; when there are several substitutes, these substitutes are identical or different from each other; provided that: one of X 1 , X 2 , X 3 , X 4 , X 5  and X 6  is N, which can regulate generation and/or activity of PDE4 and/or TNF-α. 
     EFFECT: invention discloses a novel isoindoline derivative which includes a pharmaceutical composition and use thereof. 
     20 cl, 47 ex, 2 tbl
Patent RU-2708590-C1 (RU)
Title: Method of purifying glycoluril from hydantoin impurity
Inventor: Kurgachev Dmitrij Andreevich
IPC: C07B63/00
Filed: 2019-10-11
Granted: 2019-12-09
Abstract: FIELD: manufacturing technology. 
     SUBSTANCE: invention relates to methods of purifying substances from related hardly-separable impurities by crystallization, specifically to a method of purifying glycoluril (2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-dione) from hard-separable impurities of hydantoin (2,4-imidazolidinedione), wherein hydantoin is formed as a by-product (product of condensation of urea and glyoxal at high temperature in acidic medium) and content thereof should not exceed 0.1 %. Method of purifying glycoluril from admixture of hydantoin to hydantoin level of less than 0.1 % involves applying a crystallization method by successively dissolving glycoluril with a hydantoin admixture in 85 % orthophosphoric acid while heating to 60 °C, cooling the obtained solution to room temperature and adding acetonitrile in ratio, pts. wt.: glycoluril with a hydantoin impurity of 1, 85 % orthophosphoric acid 5, acetonitrile 4, followed by washing the residue with acetonitrile, filtering and drying. 
     EFFECT: disclosed is a method of purifying glycoluril from hydantoin impurities. 
     1 cl, 1 dwg
Patent RU-2738211-C1 (RU)
Inventor: Borovitskij Vladislav Semenovich
IPC: A61B5/00
Filed: 2019-11-21
Granted: 2020-12-09
Abstract: FIELD: medicine. 
     SUBSTANCE: invention refers to medicine, namely to phthisiology, and can be used for determining the probability of an unfavourable outcome in a patient suffering from tuberculosis associated with HIV infection, when admitted to a hospital of the Federal Penitentiary Service of the Russian Federation. Patient is diagnosed with the following symptoms: dyspnoea (D) complaints, weight loss (L), presence of splenomegaly (S), fever (F), wherein in the presence of a feature, value of 1 is assigned to it, and in the absence of a value, value of 0 is given, followed by calculation using a formula. Each feature is given an experimentally determined weight value in the form of a product of constant coefficient or 1, or 0, depending on presence or absence of the attribute: (1.40486) and if dyspnoea (D) = 1, absent = 0; (1.74790) and in the presence of weight loss (L) = 1, absence = 0; (1.68617) and in the presence of splenomegaly (S) = 1, absence = 0; (1.91843) and in the presence of fever (F) = 1, absence = 0; and is summed with constant equal to (-5.35489) with subsequent calculation by formula 
     
       
     
     where e is the base of the natural logarithm = 2.71828947, z is the sum of the numerical values of each of the features, z = (-5.3489) + 1.40486 × (D) + 1.74790 × (L) + 1.68617 × (S) + 1.1843 × (F), where "D" - presence of dyspnoea, "L" - presence of weight loss, "S" - presence of splenomegaly, "F" - presence of fever. Derived probability is used to conclude that it is advisable to continue monitoring and treating a patient suffering from tuberculosis associated with HIV infection when admitted to a hospital of the Federal Penitentiary Service of the Russian Federation in the intensive care ward. If probability is 50 % or more, the risk of the unfavourable outcome and the need to hospitalize the patient in the intensive care unit are predicted, if the probability is less than 50 %, the patient is hospitalized in a hospital ward. 
     EFFECT: method provides detecting a possible adverse outcome of the disease by a limited number of clinical manifestations. 
     1 cl, 1 dwg, 2 tbl
Patent RU-2720883-C1 (RU)
Inventor: HAO XUEGUANG
IPC: G09G3/20
Filed: 2019-01-08
Granted: 2020-05-13
Abstract: FIELD: defectoscopy. 
     SUBSTANCE: invention relates to means of detecting cracks in displays. Display panel includes a display region and a peripheral area surrounding the display region, the peripheral region is provided with a contour crack detection structure. Contour structure of crack detection includes contour detection wire and first switching circuit for detection. Display panel includes a first subpixel and a first data line electrically connected to the first subpixel, a first end of the first data line is electrically connected to the first end of the loop detection wire, second end of the first data line is electrically connected to the second end of the loop detection wire through a first switching circuit for detection, and the second end of the loop detection wire is configured to receive detection voltage. 
     EFFECT: technical result consists in improvement of efficiency of detection of cracks. 
     19 cl, 14 dwg
Patent RU-2727353-C1 (RU)
Inventor: VOROBEV SERGEJ VIKTOROVICH
IPC: H04W84/00
Filed: 2020-02-13
Granted: 2020-07-21
Abstract: Изобретение относится к радиосвязи и предназначено для защиты от возбуждения многоканальных ретрансляторов, в том числе работающих в дуплексном режиме. Техническим результатом является обеспечение непрерывной стабильной работы ретранслятора при максимально возможном в данных условиях усилении, и тем самым полностью исключаются возможность его возбуждения и помехи в радиосвязи. Для защиты ретранслятора от возбуждения последовательно принимают ретранслируемый сигнал на приемную антенну, усиливают в усилителе с электронной регулировкой коэффициента усиления, декоррелируют в декорреляторе с сохранением амплитудно-фазовых характеристик модуляции и временной структуры ретранслируемого сигнала и излучают его через передающую антенну. Одновременно с этим измерителем мощности измеряют мощность сигнала на выходе ретранслятора, а коррелятором определяют значение корреляции между сигналами на входе и выходе ретранслятора, которое нормируют в функциональном делителе по отношению к измеренной мощности сигнала. Сигнал на выходе делителя обратно пропорционален коэффициенту изоляции антенн, и его используют как сигнал управления для автоматического изменения коэффициента усиления усилителя, устанавливая коэффициент усиления ретранслятора меньше чем коэффициент изоляции антенн на заданное значение. 4 н.п. ф-лы, 6 ил.
Patent RU-2729321-C1 (RU)
Inventor: KOZLOV VLADIMIR VLADIMIROVICH
IPC: F41H11/00
Filed: 2020-03-13
Granted: 2020-08-06
Abstract: Способ защиты группового объекта от средств поражения заградительным дисперсным образованием, при котором для защиты группового объекта от воздействия средств поражения создают защитную завесу путем выстрела выбросных генераторов двухфазных сред с высоким начальным уровнем порового газа на заданную высоту, с последующей их взрывной разгерметизацией и образованием дисперсных облаков. Технический результат - обеспечение гарантированной защиты группового объекта от летательных аппаратов на различных высотах. 5 ил.
Patent RU-2746746-C1 (RU)
Inventor: OKAVA Kodzi
IPC: H04N19/91
Filed: 2020-03-17
Granted: 2021-04-20
Abstract: FIELD: computing. 
     SUBSTANCE: image decoding apparatus comprising an extractor unit configured to extract quantization parameters; and a decoding unit configured to decode the encoded data using the quantization parameters, the extraction unit configured to: extract the first quantization parameter of the first line in a part including a plurality of blocks using a quantization parameter provided for said part; extracting the first quantization parameter of the second row in said part using the quantization parameter provided for said part; and extracting the n-th (n is an integer equal to or greater than 2) quantization parameter of the second row using the (n-1)th quantization parameter of the second row. 
     EFFECT: said invention is aimed at providing possibility of parallel decoding in the quality of the entire processing. 
     11 cl, 28 dwg
Patent RU-2747133-C1 (RU)
Inventor: Zinchenko Ivan Vladimirovich
IPC: B21B27/06
Filed: 2020-04-20
Granted: 2021-04-28
Abstract: FIELD: building.SUBSTANCE: invention relates to building, particularly to a method of manufacture of an adjoining profile with a net. The technical result is achieved by the method of manufacture of an adjoining profile with a net being characterized by the profile with a longitudinal recess being supplied wherein a net is installed into the recess at one end, wherein an adhesive composition is applied before the net is supplied to said recess, then the net being supplied pressed by pressure rollers wherein the working surface of the rollers is less than the width of said longitudinal recess, until the adhesive composition is set.EFFECT: highly secure net fastening.20 cl
Patent RU-2744236-C1 (RU)
Title: Gnathic device
Inventor: VOROBEV ALEKSANDR ALEKSANDROVICH
IPC: A61C7/36
Filed: 2020-04-27
Granted: 2021-03-04
Abstract: FIELD: medicine; dentistry. 
     SUBSTANCE: invention relates to medicine, namely to dentistry, and is intended for use in gnathic dentistry, as well as for the separation of the dental rows during medical manipulations in the oral cavity. The gnathic device includes a case made of medical silicone with an occlusal relief and with the edges bent outwards of the case to rest on the dental arch. The device is made detachable and consists of two bite blocks, the cases of which are made with an occlusal relief on opposite sides and are connected to each other by a vestibular arch made of medical silicone. The opposite sides of the vestibular arch are made with a fixing relief, and its ends are installed in loops rigidly fixed to the block cases. The case of each block is made in the form of a truncated pyramid with a cavity inside and a through hole in the larger base of the pyramid for installing an air valve, the case of which is made in the form of a cylinder with a through axial hole. One end of the air valve is made with flanges on the outer surface for fixing relatively to the opening of the block case, and the other end is equipped with an adjustment ring mounted on the outer surface and an internal thread for connecting to the air supply source or installing a locking device. Inside the air valve, perpendicular to its axis, there are fixed blades made in the form of mirror-arranged sectors rigidly connected by an arc to the valve case, and movable blades made in the form of mirror-arranged sectors connected to each other and with fixed blades with the possibility of rotation. The movable blades are additionally connected to the adjusting ring by means of a rod installed in a through groove made in the air valve case, and which makes it possible to rotate the movable blades at an angle of 90 degrees. 
     EFFECT: technical task and result of the present invention is to expand the functional capabilities of the device by providing a regulated and programmable effect on the hypertonus of the masticatory muscles, removing the pain effect in the muscles, eliminating dysfunction in the temporomandibular joint, as well as providing possibility of separating the dental rows during medical manipulations in the oral cavity. 
     3 cl, 4 dwg
Patent RU-2745985-C1 (RU)
Title: Anticoronavirus therapeutic agent - substituted 7-hydroxy-3,4,12,12a-tetrahydro-1h-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione for the prevention and treatment of covid-19
Inventor: IVASHCHENKO ANDREJ ALEKSANDROVICH
IPC: C07D498/14
Filed: 2020-05-07
Granted: 2021-04-05
Abstract: FIELD: medicine/biotechnology.SUBSTANCE: invention relates to the use of a compound selected from (12aR)-7-hydroxy-12-[(10S)-6,7-difluoro-5,10-dihydrothieno[3,2-c][2]benzothiepin-10-yl]-3,4,12,12а-tetrahydro-1H-[1,4]oxazino [3,4-c]pyrido[2,1-ƒ][1,2,4]triazine-6,8-dione(1.2.1) or (12aR)-7-hydroxy-12-[(10S)-7,8-difluoro-4,9-dihydrothieno[2,3-c][2]benzothiepin-4-yl]-3,4,12,12а-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-ƒ][1,2,4]triazine-6,8-dione (1.5.1) as an anti-coronavirus agent for inhibiting 2019-nCoV coronavirus. EFFECT: proposed is a new application of a compound selected from (1.2.1) and (1.5.1) as an anti-coronavirus agent for inhibiting the 2019-nCoV coronavirus.3 cl, 4 ex
Patent RU-2758359-C1 (RU)
Inventor: IVANOV SERGEJ NIKOLAEVICH
IPC: G06F21/56
Filed: 2020-06-19
Granted: 2021-10-28
Abstract: Изобретение относится к вычислительной технике. Технический результат заключается в обеспечении выявления аномальной активности при взаимодействии пользователей с удаленными сервисами. Способ выявления аномальной активности при взаимодействии пользователей с удаленными сервисами содержит этапы, на которых выявляют признаки активностей пользователей при взаимодействии пользователей с удаленными сервисами во время заданного временного интервала с помощью скрипта, исполняющегося в браузере на вычислительных устройствах пользователей при взаимодействии пользователя с веб-страницей удаленного сервиса; с помощью сервиса безопасности на основании выявленных признаков активностей пользователей выявляют активности каждого пользователя, соответствующие определенному сценарию активностей пользователя; с помощью сервиса безопасности вычисляют степень аномальности активностей пользователей, соответствующих сценарию активностей пользователя в заданном временном интервале; с помощью сервиса безопасности выявляют аномальную активность пользователей. 5 з.п. ф-лы, 3 ил.
Patent RU-2760674-C1 (RU)
Title: Use of preparations of polyscias filicifolia plant or its fragments for treatment of elementoses and their consequences
Inventor: KOTIN ARKADIJ MIKHAJLOVICH
IPC: A61K36/25
Filed: 2020-07-06
Granted: 2021-11-29
Abstract: FIELD: pharmaceutics. 
     SUBSTANCE: proposed group of inventions relates to the pharmaceutical industry, namely to the use of a preparation for the treatment of elementoses in a subject. The use of a preparation of lateral shoots or leaves of Polyscias filicifolia plant, obtained by alcohol extraction of the plant or by a biotechnological method for plant cell culture, for the treatment of elementoses in a subject in need of it is proposed, where elementoses are induced by ingestion of an extraneous chemical compound to the organism of the subject deviations in the content in one or several internal organs of the subject of at least one essential element selected from a group: Ca, Cr, I, Mn, Cu, Mg, Fe, Zn without the need to use sources or chelators of essential elements, the content of which is violated. The use of a preparation of lateral shoots or leaves of Polyscias filicifolia plant, obtained by a biotechnological method for plant cell culture, for the treatment of elementoses in a subject in need of it is proposed, where elementoses are induced by ingestion of an extraneous chemical compound and/or an infectious disease to the organism of a subject deviations in the content in one or more internal organs of the subject of at least one essential element selected from a group: Ca, Cu, Mg, Fe, Zn without the need to use sources or chelators of essential elements, the content of which is violated.  
     EFFECT: above-described use of the preparation obtained from lateral shoots or leaves of Polyscias filicifolia plant is effective for the treatment of elementoses in the subject. 
     10 cl, 10 dwg, 4 tbl, 6 ex
Patent RU-2746518-C1 (RU)
Inventor: Fedoseev Maksim Evgenevich
IPC: C23C4/18
Filed: 2020-08-24
Granted: 2021-04-14
Abstract: FIELD: mechanical engineering. 
     SUBSTANCE: invention relates to the field of mechanical engineering and namely to the technology of forming local carbide coatings on die steels and can be used to improve the surface characteristics of the die tool. The method of forming a coating on stamped steels includes electrospark alloying of a steel base and subsequent thermal modifying treatment by induction heating in an air atmosphere, while electrospark alloying is carried out with zirconium at an alternating current density of 0.7-2.3 A/mm 2  and a specific processing time of 38-77 mm 2 /min after which a carbon-containing paste is applied to the surface of the zirconium layer for carburizing and the thermal modifying treatment is carried out at a current frequency on an inductor of 100-10 kHz, a temperature of 850-1250 °C for 100-300 s after which the product is cooled in air.  
     EFFECT: invention is directed to the formation on the surface of steel products of local coatings based on zirconium carbide characterized by thickness of up to 40 mcm and hardness of up to 873±67 HV 0.98 . 
     1 cl, 2 ex, 1 tbl
Patent RU-2747997-C1 (RU)
Inventor: HUTTINGER DOMINIK
IPC: B07B11/04
Filed: 2019-04-24
Granted: 2021-05-18
Abstract: FIELD: supply of bulk material. 
     SUBSTANCE: proposed group of inventions relates to the adjustment of the intake for a feeding device intended for the supply of bulk material, a method for controlling the adjustment of the intake for the supply of bulk material, as well as to a cleaning machine intended for the cleaning of bulk material. The feeding device intended for feeding bulk material comprises a machine case, with a retaining partition located inside the machine case, a rotating feed flap that forms a gap between the retaining partition and the feed flap and is connected to the rotation axis, as well as lower and upper sensors for measuring the amount of bulk material that is located in the space between the retaining partition, the feed flap and the side walls of the machine case. The feeding device additionally contains an engine assembly, which is located outside the machine case and is rigidly connected to the axis of rotation. The engine assembly is designed to be connected to the feed flap via the rotation axis; it forms a counterweight to the feed flap. The engine assembly contains the engine and the guide rail. The engine is designed to move on a guide rail on a linear axis perpendicular to the axis of rotation in order to change the center of gravity of the engine assembly on the linear axis relatively to the axis of rotation. The size of the gap between the retaining partition and the feed flap depends on the position of the engine on the linear axis and the weight of the bulk material that lies on the feed flap. This feed device is used in a cleaning machine designed for cleaning bulk material.  
     EFFECT: increased efficiency of the flow of bulk material. 
     10 cl, 8 dwg
Patent RU-2746640-C1 (RU)
Inventor: AYUKHANOV ISKANDAR SAGITOVICH
IPC: A61M25/00
Filed: 2020-09-17
Granted: 2021-04-19
Abstract: FIELD: medical technology. 
     SUBSTANCE: group of inventions relates to medical technology, it is intended for the study of hollow spaces in horizontal, vertical and inclined directions, straight or having a complex curved shape, a variable amount of lumen, as well as for filling the cavities between the piston and the cylinder, valves, rods and other cylindrical mechanisms with reciprocating motion for the purpose of their protection, lubrication, sealing and heat dissipation. The probe for the passage of channels contains an elastic elongated shell. The shell is toroidal and has two axially arranged walls. The shell is made of a flat plate wrapped on itself and glued at the end. A cavity is formed between the outer and inner walls, in which elastic rings are installed at an equal distance, perpendicular to the axis of the shell. In the second embodiment, the probe for the passage of channels contains an elastic elongated shell. The shell is toroidal and has two axially arranged walls. The shell is made of a flat plate wrapped on itself and glued at the end. A cavity is formed between the outer and inner walls, in which an elastic pipe is installed. In the third embodiment, the probe for the passage of channels contains an elastic elongated shell. The shell is toroidal and has two axially arranged walls. The shell is made of a flat plate wrapped on itself and glued at the end. A sealed cavity is formed between the outer and inner walls, which is subjected to the pressure of an elastic medium or is under vacuum.  
     EFFECT: use of the inventions makes it possible to increase the length of the probe passage through channels with different shapes and sizes. 
     3 cl, 4 dwg
Patent RU-2768374-C1 (RU)
Inventor: NAN FANG
IPC: H04W72/04
Filed: 2018-04-04
Granted: 2022-03-24
Abstract: FIELD: electrical communication equipment. 
     SUBSTANCE: invention relates to data transmission means. Network device is no longer limited to allocating RB only in the narrow band for the BL/CE UE, but may also allocate RB outside the narrow band for the BL/CE UE so that resources are flexibly allocated by the network device for the BL/CE UE. Thus, when the network device allocates BL/CE UE resources in one subframe, the number of fragmented resources that cannot be used by the common UE in the remaining resources in the system bandwidth, can be reduced so that the remaining resources can be used by another common UE to the maximum extent. 
     EFFECT: increased efficiency of using system resources. 
     8 cl, 9 dwg, 39 tbl