Patent SG-11201807516U-A (SG)
Title: 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar
Inventor: GALLEY GUIDO
IPC: C07D413/12
Filed: 2017-03-14
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization M1111101110101011111 HO 11111 011101100111 MO Ell HEIM III 11 International Bureau 0.. .... .. ...... ... (10) International Publication Number (43) International Publication Date WO 2017/157873 Al 21 September 2017 (21.09.2017) WIP0 I PCT (51) International Patent Classification: (74) Agent: POPPE, Regina; F. Hoffmann-La Roche AG, CO7D 413/12 (2006.01) A61P 25/00 (2006.01) Grenzacherstrasse 124, 4070 Basel (CH). A61K 31/4245 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/EP2017/055885 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (22) International Filing Date: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 14 March 2017 (14.03.2017) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (25) Filing Language: English KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (26) Publication Language: English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (30) Priority Data: RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 16160790.8 17 March 2016 (17.03.2016) EP TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant (for all designated States except US): F. HOFF- MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse (84) Designated States (unless otherwise indicated, for every 124, 4070 Basel (CH). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant (for US only): HOFFMANN-LA ROCHE TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, INC. [US/US]; Overlook at Great Notch, 150 Clove Road, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 8th Floor, Suite 8 - Legal Department, Little Falls, New DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Jersey 07424 (US). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventors: GALLEY, Guido; c/o F. Hoffmann-La Roche SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, AG, Grenzacherstrasse 124, 4070 Basel (CH). HOENER, GW, KM, ML, MR, NE, SN, TD, TG). Marius; c/o F. Hoffmann-La Roche AG, Grenzacherstrasse Declarations under Rule 4.17: 124, 4070 Basel (CH). NORCROSS, Roger; c/o F. Hoff- - of inventorship (Rule 4.17(iv)) maim-La Roche AG, Grenzacherstrasse 124, 4070 Basel (CH). PFLIEGER, Philippe; c/o F. Hoffmann-La Roche Published: AG, Grenzacherstrasse 124, 4070 Basel (CH). — with international search report (Art. 21(3)) — (54) Title: 5-ETHYL-4-METHYL-PYRAZOLE-3-CARBOXAMIDE DERIVATIVE HAVING ACTIVITY AS AGONIST OF TAAR HN , ,-, M IN GC N ir)l I IN Il N (57) : The present invention relates to a compound of with a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1, for the treatment of certain CNS dis 0 eases. ( of formula I ) (I) and to a pharmaceutically suitable acid addition salt there- -