baber/WOPTO huggingface dataset:
Patent CA-3141650-A1 (CA)
Title: Gene knockout of nrf2 for treatment of cancer
Inventor: KMIEC ERIC
IPC: C12N15/113
Filed: 2020-05-22
Abstract: The disclosure provides a guide RNA (gRNA) comprising a DNA-binding domain and a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease protein-binding domain, wherein the DNA-binding domain is complementary to a target domain from an NRF2 gene. The disclosure also provides nucleic acid sequence encoding the gRNA. The disclosure further provides a method of treating cancer in a subject comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease and a guide RNA that is complementary to a target domain from an NRF2 gene in the subject. Methods of treating cancer comprising administering a pharmaceutical composition comprising: a DNA sequence encoding a guide RNA that is complementary to a target domain from an NRF2 gene in the subject; and a nucleic acid sequence encoding a Clustered Regularly Interspaced Short Palindromic Repeat (CRIS PR) -associated endonuclease, are also provided.
Patent CA-3146786-A1 (CA)
Title: Eyeglasses with simplified hinge
Inventor: NICOLIS DIEGO
IPC: G02C5/22
Filed: 2020-07-15
Abstract: Eyeglasses (1) with simplified hinge, comprising a pair of lenses (2), a pair of temples (3) and a hinge for connection between each one of the temples and the lenses; the hinge comprises an element (7) for connecting the lens (2) and the temple (3), adapted to be connected to the lens at one end and provided, at the opposite end, with a portion (6) adapted to engage a retention and locking element (9), the temple (3) being provided with a cavity (4) adapted to accommodate and lock the retention and locking element (9), the retention and locking element (9) acting as a rotation fulcrum for the temple (3) with respect to the connecting element (7).
Patent CA-3146987-A1 (CA)
Inventor: SHIMASAKI NORIKO
IPC: A61K39/395
Filed: 2020-07-15
Abstract: The invention relates to an in vivo functional ligands (IFLs) including a single-chain variable fragment (scFv) domain, a fragment crystalIizable (Fc) domain, and a hinge domain joining the scFv and Fc domains. The IFLs specifically bind target receptors and are capable of triggering antibody-dependent cell cytotoxicity (ADCC), antibody-dependent cell phagocytosis (ADCP) and complement-dependent cytotoxicity (CDC), as well as cytokine stimulation. The IFLs may be joined to a chimeric antigen receptor via a self-cleaving peptide. The IFLs may be expressed in immune cells, such as a natural killer cell or a T lymphocyte. Vectors, host cells, and methods of making IFLs are also described.
Patent CA-3148205-A1 (CA)
Title: Interconnecteur revetu d'une couche protectrice, assemblage de cellules comprenant ledit interconnecteur et pile a combustible comprenant l'assemblage
Inventor: KOBAYASHI SHOHEI
IPC: C25B9/65
Filed: 2022-02-01
Abstract: Il est décrit un interconnecteur revêtu d'une couche protectrice, une unité de pile et une pile à combustible. Un composant (particulièrement le chrome) de l'interconnecteur ne peut pas se diffuser même si l'interconnecteur est exposé à une température élevée pendant une longue période. [Solution] Un interconnecteur revêtu d'une couche protectrice, une unité de pile comprenant l'interconnecteur, et une pile à combustible comprenant l'interconnecteur, où l'interconnecteur comprend un matériau d'interconnecteur et une couche protectrice sur la surface du matériau d'interconnecteur, où le matériau d'interconnecteur est composé d'un alliage de fer et de chrome contenant un élément de terre rare ou un élément de zirconium d'une quantité totale de 1,0 % massique ou moins, et où la couche protectrice est composée d'un oxyde de carbone ou d'un oxyde contenant : au moins un élément sélectionné à partir du groupe comprenant l'aluminium, le titane, le chrome, le fer, le nickel, le cuivre et le zinc; et un élément de carbone.
Patent CA-3150938-A1 (CA)
Title: Dry pet food manufacturing method
Inventor: DAVIES JONATHAN
IPC: A23K10/30
Filed: 2019-09-12
Abstract: There is provided a method of manufacturing a dry pet food, comprising receiving (10) unprocessed meat, grinding (11, 14) the unprocessed meat, forming (15) the ground meat into a slab or a plurality of strips, passing (16) the formed meat through a steam cooker and cutting (17) the meat into chunks, and drying out (18, 19) the chunks.
Patent CA-3153155-A1 (CA)
Inventor: BRANDAUER PAUL WILBUR HEISEY
IPC: A47F3/02
Filed: 2020-09-04
Abstract: La présente invention concerne un kiosque destiné à stocker, afficher et distribuer une pluralité de produits cuits. Le kiosque peut comprendre, par exemple, une structure délimitant une chambre à l'intérieur et conçue pour recevoir une pluralité de produits cuits. Le kiosque peut comprendre un ou plusieurs capteurs conçus pour analyser les produits cuits individuellement afin de déterminer un ou plusieurs paramètres d'unité de cuisson et ajuster une ou plusieurs entrées de cuisson sur la base des paramètres mesurés.
Patent CA-3155995-A1 (CA)
Title: Polymer composites, methods of fabrication and uses thereof
Inventor: OUYANG JIANYONG
IPC: C08L75/04
Filed: 2020-10-16
Abstract: The invention relates to a polymeric composite comprising poly(ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), waterborne polyurethane (WPU) and a sugar alcohol, wherein the sugar alcohol is selected from the group consisting of glycerol, erythritol, threitol, arabitol, xylitol, ribitol, mannitol, sorbitol, galactitol, fucitol, iditol, inositol, volemitol, isomalt, maltitol, lactitol, maltotriitol, maltotetraitol, polyglycitol, or a combination thereof, and wherein the sugar alcohol is 20 wt% to 50 wt% of the polymer composite; an electrical device comprising such composite. The present invention also relates to methods of fabricating and its uses thereof. In particular, the present invention relates to intrinsically conductive polymer composites suitable for use in efficient dry/wet epidermal biopotential monitoring. The polymer composites are advantageously self-adhesive and stretchable, and can be used as dry electrodes.
Patent CA-3158236-A1 (CA)
Title: Implement management system for determining implement state
Inventor: SCHLEICHER TYLER D
IPC: A01B76/00
Filed: 2022-05-04
Abstract: An implement management system detects implement wear and monitors implement states to modify operating modes of a vehicle. The system can determine implement wear using the pull of the implement on the vehicle, the force and angle of which is represented by an orientation vector. The system may measure a current orientation vector and determine an expected orientation vector using sensors and a model (e.g., a machine learned model).  Additionally, the implement management system can determine an implement state based on images of the soil and the implement captured by a camera onboard the vehicle during operation. The system may apply different models to the images to determine a likely state of the implement. The difference between the expected and current orientation vectors or the determined implement state may be used to determine whether and how the vehicle's operating mode should be modified.
Patent CA-3158400-A1 (CA)
Inventor: LEITES RICK
IPC: E05B9/00
Filed: 2022-05-05
Abstract: An electronic door lock system includes a gasket system for protecting electrical and mechanical components from exterior water and air. A lock portion may include a gasket, a circuit board, and a plate disposed between a first and second housing. The gasket includes an L-shaped perimeter that wraps around a first side and perimeter edge of the circuit board. The plate compresses the gasket perimeter against a ridge on the first housing to form a seal around the circuit board.
Patent CA-3162662-A1 (CA)
Title: Tremie pour l'alimentation de materiau en vrac
Inventor: CHLEBOVEC MICHAL
IPC: B65G11/02
Filed: 2021-01-11
Abstract: L'invention concerne un appareil et un procédé d'alimentation de matériau en vrac. Plus particulièrement, l'invention concerne un appareil et un procédé d'alimentation de matériau en vrac tel que des solides en vrac, qui permettent une alimentation constante et fiable de matériau.
Patent CA-3163216-A1 (CA)
Inventor: Wang xiaozhao
IPC: C07D487/04
Filed: 2021-01-08
Abstract: Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer. (I)
Patent CA-3163708-A1 (CA)
Inventor: TANG YI
IPC: C12N9/00
Filed: 2021-01-09
Abstract: L'invention concerne des plateformes de biosynthèse qui génèrent de l'acide olivetolique et ses analogues à des titres élevés à partir de microbes, et dans des systèmes acellulaires.
Patent CA-3165958-A1 (CA)
Inventor: RIMCHALA THARATHON
IPC: G06V30/413
Filed: 2022-06-28
Abstract: Multimodal multitask machine learning system for document intelligence tasks includes a feature extractor processing token values obtained from a document to obtain features, and a token extraction head classif)fing, using the features, the token values to obtain classified tokens. The classified tokens are aggregated into entities. A document classification model is executed on the features to classify the document and obtain a document label prediction. Further a confidence head model applying the document label prediction processes the entities to obtain a result.
Patent CA-3166145-A1 (CA)
Inventor: MARSH JOHN P
IPC: G06T7/62
Filed: 2021-12-20
Abstract: A building appraisal system conducted by a remote inspector located away from a building. A remote user connected to a user on site can share images, measurements and other data to conduct an examination of the building such as an appraisal. A processor coupled to an image sensor can be configured to receive a gross floor area of the building. Images of an interior room of the building are stored in memory. The processor determines a planar surface in the images corresponding to a floor surface of the interior room,and a plurality of corners in the images forming vertices of a bounded floor area on the floor surface. The processor can compute an adjusted floor area of the building that includes the bounded floor area subtracted from the gross floor area.
Patent CA-3169210-A1 (CA)
Title: Derive de lignine pour reduire un film de lave-vaisselle
Inventor: ELLIS ROSS JOHANNES
IPC: C11D1/30
Filed: 2021-02-17
Abstract: La présente invention concerne l'utilisation de dérivés de lignine pour réduire et/ou prévenir des dépôts sur un objet pendant un processus de lavage de la vaisselle en machine. En outre, la présente invention concerne un procédé de réduction et/ou de prévention de dépôts sur un objet et une formulation détergente pour lave-vaisselle comprenant le dérivé de lignine décrit ici.
Patent CA-3169522-A1 (CA)
Inventor: GRASSI FABIO
IPC: A61P1/14
Filed: 2021-06-08
Abstract: The present invention provides an ATP hydrolyzing enzyme, a nucleic acid encoding an ATP hydrolyzing enzyme, or host cells, microorganisms, such as bacteria, or viral particles comprising such nucleic acids encoding an ATP hydrolyzing enzyme for use in the treatment of dysbiosis or a dysbiosis-related disease.
Patent CA-3169703-A1 (CA)
Inventor: USAMI YUSUKE
IPC: G06V30/10
Filed: 2021-03-02
Abstract: According to an embodiment, the recognition apparatus includes an image interface, an input interface, and a processor. The image interface is configured to acquire a display screen image from an input device for inputting a character string included in a captured image in which recognition of the character string according to a first algorithm fails. The input interface is configured to input the character string to the input device. The processor is configured to acquire a result of character recognition processing performed on the display screen image according to a second algorithm different from the first algorithm, and input the character string based on the result of the character recognition processing to the input device through the input interface.
Patent CA-3169802-A1 (CA)
Inventor: STOMAKHIN ALEXEY
IPC: G06T13/60
Filed: 2021-02-26
Abstract: A method for generating visual representations of interactions between two different materials is provided. The method can be performed using a computing device operated by a computer user or artist. The method includes modeling a primary material as a plurality of first particles and modeling a layer portion of a secondary material as a fluid volume. The secondary material can include a layer portion positioned between the plurality of first particles and an outer portion. At least one boundary condition might be assigned to a boundary positioned between the layer portion and the outer portion, the at least one boundary condition includes at least one pressure value. Values of motion parameters might be determined by applying the at least one boundary condition at the boundary and generating one or more visual representations of the primary material interacting with the secondary material based on the values of the motion parameters.
Patent CA-3171050-A1 (CA)
Inventor: HILL JONATHAN
IPC: C08K5/3435
Filed: 2021-03-11
Abstract: L'invention concerne une composition de phosphites hydrolytiquement stabilisée, comprenant : a. un antioxydant phosphite qui est un liquide dans les conditions ambiantes et qui comprend un mélange d'au moins deux différents phosphites de Formule (I) : dans laquelle R1, R2 et R3 sont indépendamment choisis parmi les groupes aryle alkylés de Formule II : dans laquelle R4, R5 et R6 sont indépendamment choisis dans le groupe consistant en hydrogène et alkyle en C1 à C6, à la condition qu'au moins l'un de R4, R5 et R6 dans chaque phosphite soit choisi dans le groupe consistant en tert-butyle et/ou tert-pentyle; et b. un composé contenant de l'azote comprenant un atome d'azote, l'atome d'azote : i ayant une valeur de pKaH d'environ 7 à environ 11; et ii. étant hybridé sp3, et le composé contenant de l'azote étant dépourvu de tous protons labiles.
Patent CA-3172148-A1 (CA)
Title: Gas mixing system for medical ventilator
Inventor: GODARA NEIL
IPC: A61M16/08
Filed: 2021-04-09
Abstract: The present disclosure relates generally to medical devices and, more particularly, to a gas mixing system for a medical ventilator. A gas mixer is provided to adjust the oxygen concentration of environmental air for a blower-based ventilator, by adjusting the mix of air upstream of the ventilator and providing the mixed air to the ventilator's environmental air inlet.
Patent CA-3172355-A1 (CA)
Inventor: BURKE JOHN
IPC: F23D14/40
Filed: 2021-03-08
Abstract: Provided is a torch including a body having a first portion and a second portion angled relative to the first portion, a control knob at a top of the second portion for adjusting a flow of fuel through the torch, a trigger at a top of the first portion that is movable from an off position to an on position to at actuate an igniter, and a burn tube extending from an end of the second portion away from the first and second portions.
Patent CA-3174068-A1 (CA)
Inventor: KHVOROVA ANASTASIA
IPC: A61K31/713
Filed: 2021-07-16
Abstract: La présente invention concerne des oligonucléotides conjugués qui sont caractérisés par une distribution tissulaire efficace et spécifique avec une efficacité de silençage in vivo améliorée.
Patent CA-3177745-A1 (CA)
Inventor: MARGER THIBAUT
IPC: B63H3/08
Filed: 2022-09-28
Abstract: A pitch change actuation system (310) for varying a propeller blade pitch, the pitch change actuation system (310) comprising: an actuator body (340) defining an interior volume (360); a chamber separator (380) located within the interior volume (360) of the actuator body (340) and dividing the interior volume (360) into a first chamber (360a) and a second chamber (360b), the two chambers being fluidly separated by the chamber separator (380). The first and second chambers (360a, 360b) are configured to receive hydraulic fluid. The actuator body (360) is configured to translate relative to the chamber separator (380) in response to a difference in hydraulic pressure between the first chamber (360a) and second chamber (360b); and the translation of the actuator body (340) is configured to effect a change in propeller blade pitch.
Patent CA-3180001-A1 (CA)
Inventor: CAMPIN JOHN ALFRED
IPC: A61F2/16
Filed: 2021-05-25
Abstract: Système et procédé de sélection d'une lentille intraoculaire, pour l'implantation dans un ?il, comprenant un dispositif de commande ayant un processeur et une mémoire tangible non transitoire sur laquelle des instructions sont enregistrées. Le dispositif de commande est configuré pour exécuter sélectivement un modèle d'apprentissage machine entraîné avec un ensemble de données d'apprentissage. L'exécution des instructions par le processeur amène le dispositif de commande à obtenir des données objectives pré-opératoires pour le patient, comprenant une ou plusieurs mesures de l'?il anatomique. Le dispositif de commande est configuré pour obtenir des données de questionnaire pré-opératoires pour le patient, comprenant au moins un trait de personnalité. Les données objectives pré-opératoires et les données de questionnaire pré-opératoires sont entrées en tant qu'entrées respectives dans le modèle d'apprentissage machine. Un score de résultat subjectif prédit pour le patient est généré en tant que sortie du modèle d'apprentissage machine. La lentille intraoculaire est sélectionnée sur la base, en partie, du score de résultat subjectif prédit.
Patent CA-3181097-A1 (CA)
Title: Ensemble levier d'arret au palier d'un ascenseur a vide pneumatique et son procede d'actionnement
Inventor: BABU KILLAKATHU RAMANATHAN
IPC: B66B9/04
Filed: 2020-09-11
Abstract: La présente invention concerne un ensemble levier d'arrêt au palier d'un ascenseur à vide pneumatique. L'ensemble comprend une plaque de levier d'arrêt au palier accouplée sur un toit d'une cabine d'ascenseur. L'ensemble comprend également une plaque de verrouillage accouplée à la plaque de levier d'arrêt au palier à l'aide d'une pluralité de plaques de support. L'ensemble comprend en outre une électrovanne disposée sur la plaque de levier d'arrêt au palier et accouplée mécaniquement à la plaque de verrouillage à l'aide d'une broche de guidage, la broche de guidage étant conçue pour actionner la plaque de verrouillage par coulissement à l'intérieur de l'électrovanne, dans au moins un mode de fonctionnement, sur la base d'un signal d'activation reçu en provenance d'un capteur magnétique.
Patent CA-3184593-A1 (CA)
Title: Proportional flow control valve
Inventor: SOBKA DAVID M
IPC: F16K1/02
Filed: 2022-12-23
Abstract: A valve apparatus that includes a valve assembly including a valve retainer body that houses a movable poppet that defines a valve member that is configured to contact a conically shaped valve seat of the valve retainer body;  and a motor assembly including a rotatable shaft that is configured to actuate the valve assembly; wherein the rotatable shaft includes a thread formed at an end thereof, the thread being engaged with a sleeve that through rotation of the thread by the rotatable shaft will translate the sleeve towards and away from the movable poppet to transfer an axial force to the poppet that forces the valve member into engagement and disengagement with the valve seat to open and close the valve assembly.
Patent CA-3190204-A1 (CA)
Title: Extended release pharmaceutical formulation
Inventor: GLUE PAUL WILLIAM
IPC: A61P25/24
Filed: 2021-09-22
Abstract: The disclosure provides a dosing regimen utilizing an oral extended release formulation for the treatment of treatment- resistant depression and treatment-resistant anxiety.
Patent CA-3194022-A1 (CA)
Inventor: NGO ANDREW
IPC: G06Q10/087
Filed: 2023-03-23
Abstract: Methods and system for managing inventory in the context of online transactions involving blockchain-based payments. Examples may include determine an inventory count associated with an item with which a user device initiates a payment involving a blockchain transaction.  The system determines a likelihood of completion with regard to the blockchain transaction based on one or more metrics related to recent transactions on the blockchain.  Responsive to the likelihood of completion being above a minimum threshold value, the system records a hold in memory in association with the inventory count and then determines that the blockchain transaction has been completed and, in response, removes the hold from memory and decrements the inventory count.
Patent CA-3198465-A1 (CA)
Title: Stanchion with illuminated or lighted banner
Inventor: WEINER STEVEN LEWIS
IPC: E01F13/02
Filed: 2021-11-16
Abstract: A safety stanchion includes a base. A post extends from the base. A belt reel has an interior for holding the belt. A belt is retractably mounted within the interior. The belt has an electroluminescent (EL) material operatively connected to a power source. The electroluminescent (EL) material is visible to the general public, when extended form within the interior.
Patent CA-3200454-A1 (CA)
Title: Interlocking, reconfigurable, reconstitutable, reformable cell-based space system
Inventor: HELVAJIAN HENRY
IPC: F16S5/00
Filed: 2018-06-14
Abstract: Cell-based systems may interlock in a reconfigurable configuration to support a mission. Space systems, for example, of a relatively large size may be assembled using an ensemble of individual "cells", which are individual space vehicles. The cells may be held together via magnets, electromagnets, mechanical interlocks, etc. The topology or shape of the joined cells may be altered by cells hopping, rotating, or "rolling" along the joint ensemble. The cells may be multifunctional, mass producible units. Rotation of cell faces, or of components within cells, may change the functionality of the cell. The cell maybe collapsible for stowage or during launch.
Patent CA-3204689-A1 (CA)
Inventor: GRAY NATHANAEL CHARLES
IPC: A61M16/00
Filed: 2021-12-17
Abstract: This present disclosure relates to a system and method for providing a flow of respiratory gases to a patient. The system includes a controller, a flow modulator, and one or more sensors, wherein the controller is configured to control the flow modulator to modulate the flow of respiratory gases in response to determined pressure in the system exceeding or not exceeding a pressure threshold value.
Patent CA-3207125-A1 (CA)
Inventor: KEL'IN ALEXANDER V
IPC: C07H21/02
Filed: 2021-12-30
Abstract: This invention relates to a compound comprising a structure of formula (I): cyclic disulfide moiety  phosphorus coupling group (I). The cyclic disulfide moiety has the structure of (C-I), (C-II), or (C-III). This invention also relates to an oligonucleotide comprising one or more compounds that comprise the structure of formula (I), wherein at least one phosphorus coupling group contains a nucleoside or oligonucleotide. The invention also relates to a pharmaceutical composition comprising the oligonucleotide described herein and a method of reducing or inhibiting the expression of a target gene by administering to the subject a therapeutically effective amount of the oligonucleotide described herein.
Patent CA-3207753-A1 (CA)
Inventor: DETERLING JESSICA
IPC: C07D211/14
Filed: 2022-01-06
Abstract: The present disclosure includes, among other things, lipids, compositions, and methods useful for delivering a polynucleotide or oligonucleotide, e.g., viral genome.
Patent CA-3208726-A1 (CA)
Inventor: HEN ASSAF
IPC: A61B17/132
Filed: 2022-02-16
Abstract: The present invention relates to a blood vessel compression system that includes blood vessel compression assemblies and apparatus for the insertion thereof.