baber/WOPTO huggingface dataset:
Patent AP-1610-A (AP)
Title: HIV replication inhibiting pyrimidines.
Inventor: GUILLEMONT JEROME EMILE GEORGES
IPC: A61K/
Filed: 2002-08-09
Granted: 2006-05-08
Abstract: This invention concerns HIV replication inhibitors of formula (I) the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, wherein the ring containing -a1=a2-a3=a4- and -b1=b2-b3=b4- represents phenyl, pyridyl, pyrimidinyl, pirazinyl, pyridazinyl;n is 0 to 5; m is 1 to 4; R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; C1-6alkyl; C1-6alkyloxycarbonyl, substituted C1-6alkyl, C1-6alkylcarbonyl; R2 is hydroxy, halo, optionally substituted C1-6alkyl, C3-7cycloalkyl, optionally substituted C2-6alkenyl, optionally substituted C2-6alkynyl. C1-6alkyloxy, C1-6alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S(=O)?R6, -NH-S(=O)?R6, -C(=O)R6, -NHC (=O) H, -C(=O)NHNH?2?, -NHC (=O)R6, -C(=NH)R6 or a 5-membered heterocycle; X1, is -NR5-, -NH-NH-, -N=N-, -O-, -C(=O)-, C1-4alkanediyl, -CHOH-, -S-, -S(=O) ?-, -X2-C1-4alkanediyl- or -C1-4alkanediyl-X2-; R3 is NHR13; NR13R14; -C(=O)-NHR13; -C(=O)-NR13R14; -C(=O)-R15; -CH=N-NH-C(=O)-R16; substituted C1-6alkyl; optionally substituted C1-6alkyloxyC1-6alkyl; substituted C2-6alkenyl; substituted C2-6alkynyl; C1-6alkyl substituted with hydroxy and a second substituent; -C(=N-O-R8)-C1-4alkyl; R7; or -X3-R7; R4 is halo, hydroxy, C1-6alkyl, C3-7cycloalkyl, C1-6alkyloxy, cyano, nitro, polyhaloC1-6alkyl, poIyhaloC1-6alkyloxy, aminocarbonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonyl, formyl, amino, mono- or di(C1-4alkyl)amino; their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them.
Patent EC-SP11011304-A (EC)
Title: Compuestos en calidad de antagonistas de bradiquinina b1
Inventor: DOODS HENRI
IPC: A61K31/165
Filed: 2011-09-02
Abstract: Objeto de la presente invención son los compuestos de la fórmula general Ien la que n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 y X se definen como se describe posteriormente, sus enantiómeros, sus diastereoisómeros, sus mezclas y sus sales, en especial sus sales fisiológicamente tolerables con ácidos o bases orgánicos o inorgánicos, que presentan valiosas propiedades, su preparación, los medicamentos que contienen los compuestos farmacológicamente eficaces, su preparación y su uso.
Patent GB-189701623-A (GB)
Title: An Improved Shunting or Arranging Signal for Use on Railways.
Inventor: DOUGLAS SHOLTO
Filed: 1897-01-21
Granted: 1897-03-27
Abstract: 1623. Douglas, S. Jan. 21. Trains, making up, arrangements for.-Relates to a shunting indicator for marking the places or limits of tracks for arranging trains. The indicator consists of a porcelain cap A, coloured in sections a, b, as shown, and affixed to a concrete plug B. The plug can be moulded or made up in the position in which the indicator is required.
Patent GB-189704562-A (GB)
Title: Improvements in Machines for Automatically Making Cigarettes.
Inventor: THOMPSON WILLIAM PHILLIPS
Filed: 1897-02-19
Granted: 1898-02-19
Abstract: 4562. Thompson, W. P., [Soc. Braunstein FrÞres and Chambon, L.]. Feb. 19. Cigarette-making machines.-In this machine, a continuous strip of paper from a roll is printed and paraffined or otherwise tipped, and formed into a tube, which is cut into pieces of suitable length. The paper tubes are filled with tobacco, which is rolled round a wire helix and pushed by its means into the tubes. The helix is withdrawn with a twist so as to leave the tobacco in the tube, which is then trimmed by rotary knives. The apparatus for tipping is shown in Fig. 11. Paraffin in the bath B' is conveyed by the rollers B<6>, B<1>, B<8> to the wheel B', provided with segments B<2>, B<3> which paraffin the paper strip at the required intervals. The roller B<1> is covered with blotting- paper. Fig. 5 is a section of the tobacco-feeding and filler-rolling apparatus. The belts G<2>, G convey the tobacco intermittently to the combined knife and press I, and rollers J roll it about the helix A', seen in Fig. 8. The tubes, cut by the usual process from the continuous tube and conveyed in holders arranged on the circumference of a wheel, are pushed by the pusher E into the mouth of the funnel or hopper D and gripped by the jaws F, the tobacco being then forced in and the helix withdrawn. The ends of the cigarette are then trimmed by the knives K.
Patent GB-189705099-A (GB)
Title: An Improvement in Sprocket Wheels for Cycles and other Gear Wheels.
Inventor: LOGAN CHARLES HENRY
Filed: 1897-02-25
Granted: 1898-02-25
Abstract: 5099. Logan, C. H., Wedderburn, W. H., and Knight, R. H. W. Feb. 25. Chain-wheels; toothed wheels.-The rim A is formed with arms a and the boss B with arms b; these arms are bedded in a disc of india-rubber or the like, interposed between the boss and the rim and between metal discs C, E. The arms a are secured by rivets D to the disc C, which is slotted to receive the rivets ; other rivets F pass through the arms b and through both discs. The Figures shows the crank P of a bicycle riveted to the boss.
Patent GB-189708399-A (GB)
Title: Improvements in Centrifugal Washing Apparatus for Coals, Ores, and other Granular and Pulverulent Materials.
Inventor: THOMPSON WILLIAM PHILLIPS
Filed: 1897-04-01
Granted: 1897-05-15
Abstract: 8399. Thompson, W. P., [Maurice, P., and Soc. Nouvelle des •tablissements de l'Horme et de la Buire]. April 1. Washing coal, ores, &c., centrifugal apparatus for. Fig. 1 shows one form of the apparatus, partly in section. The ore is charged on to a rotary perforated table A, and is subjected to the action of water pumped into the chamber B by the piston H. Under the pulsating action of the water and centrifugal action a separation takes place. The lightest particles are discharged over the annular valve 0 into a chamber M, the next grade over P into L, and the heaviest into K. The annular valves O and P are supported by screwed rods Q, Q<1>, by which they may be adjusted. A cylinder or screen N may be lowered to close the apertures between the valves. The chamber B is provided with a valve opening operated by a treadle Z through which mud or sediment may be removed. The chambers K, L, M lead to collecting or settling tanks, and the water is pumped back from the tank I for reuse. Grated valves G, G' are arranged in the pipes to regulate the flow of water. In a modified arrangement, the vessel or table A is not perforated, but is tapped by suitably-operated hammers, the water being supplied from above.
Patent GB-189712643-A (GB)
Title: An Improved System of Conductors for Electric Railways.
Inventor: LACHMANN EDUARD
Filed: 1897-05-21
Granted: 1897-06-26
Abstract: 12,643. Lachmann, E. May 21. Electric railways and tramways on a three-wire system. The exposed conductors on which the collectors run, here shown on the overhead system, are alternately positive and negative, and the non- exposed portions are placed alongside. The current is picked up by a number of collectors c, and between them and the motors on the vehicle an automatic reversing-switch is placed to maintain a uniform direction for the current to the motors. As shown in Fig. 2, this consists of a rocking arm w for each collector, working over two pairs of contacts f, f<1>, and operated by a magnet N acting on the coils k, which are included in the circuit l from the collectors so as to be attracted alternately according to the current. In case of alternating currents this switch is unnecessary.
Patent GB-189716829-A (GB)
Title: Improvements in and connected with the Furnaces of Steam Generators and other like Furnaces.
Inventor: BROADBENT JOSEPH KNOWLES
Filed: 1897-07-16
Granted: 1898-03-12
Abstract: 16,829. Broadbent, J. K. July 16. Steam-generator &c. furnaces; firebars and grates; ashpits; arches; smoke-consuming.-Relates to furnaces adapted for burning inferior fuel and small coal. Transverse rocking firebars A are employed. Each bar is in the form of a grid and is carried by end pivots in a line with the back edge of the bar. By means of depending levers and the connecting-rod F the bars may be simultaneously actuated from the front, being raised slowly and dropped suddenly. The unconsumed residue of the fuel is worked by the motion of the grate into the chamber J, which, as shown in Fig. 1, is constructed with a perforated hearth through which steam may be blown. An arch M in contact with the boiler plates is provided, which, becoming highly heated, promotes complete combustion. In the modification shown in Fig. 5, the ash space J is formed between the end of the grate and the bridge L, the ashes &c. being removed through the door 0. In each case, accessories such as steam pokers and blowers, automaticallyactuated louvres, &c. may be employed.
Patent GB-189724325-A (GB)
Title: Improvements in Rotary Motors.
Inventor: BURGESS CHARLES
Filed: 1897-10-21
Granted: 1898-10-21
Abstract: 24,325. Burgess, C. Oct. 21. Annular-chamber type.-The rotary drum b is provided with vanes c which project across the annular chamber x. To this chamber the steam or other actuating-fluid is admitted bv an oscillating valve m, which is actuated through the spindle n, lever p, and stud k by the cam l. A cut-off u is provided to permit of the steam being worked by expansion. The drum b is packed by rings gl and springs h let into thickened portions of the side plates e.
Patent GB-189725358-A (GB)
Title: Improvements appertaining to Clothes-holding Devices, applicable for Use in connection with Fire-places.
Inventor: COWBURNE JAMES HENRY
Filed: 1897-11-02
Granted: 1898-10-22
Abstract: 25,358. Cowburne, J. H. Nov. 2. Drying stoves.-The Figures show frames for holding clothes in front of a fire. Two or more metal or wooden rods or tubular bars a are mounted in suitable clamps b having set-screws c. These clamps are pivoted and vertically adjustable upon spindles d carried by lever arms e supported by bearings g and g<1> secured to the mantle shelf k and jamb h of a fireplace, or, as shown in Fig. 6, the clamps are pivoted to lever arms f mounted and vertically adjustable upon spindles f<2>. In a modification, the spindles d take over horizontal bars secured near the ceiling of the room. Supplementary tubular bars, supported from the rods a by means of hooks, may be used. The bearings g are constructed in two parts made to grip the jamb by means of a binding-screw. Fig. 6 shows the bearing g made in two parts, each having serrations s which interlock and are held together by a bolt t.
Patent GB-189727821-A (GB)
Title: Apparatus and Mechanism for the Display of Inscriptions, Pictures, and the like for the Purpose of Advertisement.
Inventor: UPWARD ALFRED RENE
Filed: 1897-11-26
Granted: 1899-02-25
Abstract: 27,821. Upward, A. R., and Dalmer, R. Nov. 26. Advertising.-Relates to improvements on the invention described in Specification No. 6736, A.D. 1895, in which rollers of triangular or other section, bearing pictures or inscriptions for advertising purposes, are rotated intermittently for presenting different surfaces to view. According to the present invention, the rollers S, bearing the advertisements, are rotated intermittently through a rack R by means of solenoids and cores C<1>, C<3> at each end, the cores being connected with the rack by cords passing over pulleys, as shown in Fig. 1. The current is regulated so that the solenoids C', C<3> operate alternately ; and meanwhile a solenoid C<3> is energized to withdraw a stop which engages with a pawl N on the rack. The current is automatically switched on the several solenoids by means of a switch, Fig. 2, which may be placed at a distance from the apparatus. The switch consists of a stationary wheel A of non-conducting material, cut away, as shown, and having on its surface three conducting-plates 1, 2, 3 connected with the solenoids C<1>, C<2>, C<3> respectively. A brush or contact D, carried by the arm B mounted on the shaft C rotated by a suitable motor, is caused to move over the face of the wheel and to make contact with the conducting-plates in succession.
Patent GB-189729559-A (GB)
Title: Improvements in Apparatus for Separating Oil, Grease, or like Extraneous Matter from Exhaust Steam.
Inventor: KINCAID JOHN GEORGE
Filed: 1897-12-14
Granted: 1898-10-22
Abstract: 29,559. Kincaid, J. G., and Crockatt, W. Dec. 14. Feedwater, purifying.-Relates to apparatus of the kind described in Specification No. 12,784, A.D. 1894, designed for separating oil, grease, or like extraneous matter from exhaust steam during its passage from the engine to the condenser. In lieu of, or in addition to, the helical vanes formed in the exhaust pipe or casing according to the previous invention, (1) a hollow cone or bell C', Fig. 1, of which the base is larger than the inlet to the condenser is employed ; or (2) the exhaust may be discharged into a cup Q, Fig. 3, forming a receptacle for the deposited matter ; or (3) louvres or baffles R<1>, Fig. 4, disposed over a receiver R, may be used.
Patent GB-189730689-A (GB)
Title: Process and Apparatus for the Manufacture of Imflammable Gas, and Composition to be used therein.
Inventor: LEE GEORGE WASHINGTON
Filed: 1897-12-28
Granted: 1898-03-05
Abstract: 30,689. Lee, G. W., Elliott, F., and Tatham, G. Dec. 28. C o m p r e s s i n g.- An inflammable gas for illuminating, heating, and motive power purposes is made by first impregnating air with aqueousvapourand then passing it through a carburetter. The air supplier and moistener consists of a cylindrical chamber A mounted in a water trough B on a rotatable shaft a and fitted with two or more radial vanes A<1>, A<2>, on opposite sides of which at either end are arranged the air inlet and outlet openings. As the shaft is rotated by a weight motor or other means, air is forced into the compartment C and thence through the pipes c to the carburetter D. The construction of the apparatus is such that, when the consumption of gas ceases, its action is automatically stopped.
Patent GB-189802913-A (GB)
Title: Pneumatic Shuttlecock.
Inventor: MILTON FREDERICK SEYMOUR
Filed: 1898-02-05
Granted: 1898-04-16
Abstract: 2913. Milton, F. S., and Milton, A. E. Feb. 5. Shuttlecocks.- Consists in forming the base of the shuttlecock with a pneumatic cushion. In the form shown, the rubber or like cover A is secured by flanges a, b to a wood or cork disc B into which the feathers C are placed.
Patent GB-189805463-A (GB)
Title: Improvements in Apparatus for Retaining or Holding Cycles in Railway Vans and other places.
Inventor: HARRINGTON JOHN
Filed: 1898-03-05
Granted: 1898-10-22
Abstract: 5463. Harring- ton, J. March 5. Wagons for velocipedes.-A plan of the apparatus, which is arranged for carrying six bicycles, is shown. A frame a<1> is pivoted at each end of a plate a secured to the roof Each frame a<1> carries two vertically-sliding bars d the lower ends of which are forked at d<3> to engage with the handle-bar of a bicycle and are also joined by a transverse p l a t e carrying a clip d' to engage with the steering-post of the bicycle frame. Two rods c are pivoted to the lower ends of the frames a<1>, and carry four hinged arms e, e<x>, each of which engages with the handlebar of a bicycle by means of two spring clips e<4>, e<5>. These arms e<x> may, if preferred, be carried on the walls of the wagon.
Patent GB-189806796-A (GB)
Title: Improvements in Mechanical or Brazeless Joints for Connecting together Parts of Cycle, and like Framings.
Inventor: SANGSTER CHARLES THOMAS BROCK
Filed: 1898-03-21
Granted: 1899-01-14
Abstract: 6796. Sangster, C. T. B. March 21. Joints, tubular. The tube is expanded within the socket or lugs d by a divided liner or bush a expanded by a screw c<2> working in a conical plug or nut f. The split liner is grooved circumferentially at a<2>, the ends are dished at a<3>, and the conical hole is made nearer to one end of the liner than the other so as to cant the sections and increase the grip on the tube. Instead of making the liner in two parts, it may be made in one piece, slotted longitudinally to within a short distance of the lower edge.
Patent GB-189808619-A (GB)
Title: Improvements in Wheels for Carriages, Omnibuses, and other like Vehicles.
Inventor: BROAD-SMITH JANE
Filed: 1898-04-13
Granted: 1899-02-25
Abstract: 8619. Broad-Smith, J. April 13. Hubs; spokes; axle-boxes.-Wheels for carriages, omnibuses, and like vehicles are provided with hubs shown in Fig. 2, and spokes shown in section in Fig. 4. The spokes a are formed of two pieces of flat steel, and are fixed in sockets p in the hub. The hub consists of a main part e with a shoulder b and a tubular projection c, a loose collar f, and a circular nut g kept in position by set-screws or other means, and a screwed cap k. Wood packing is fitted inside the hub, and the axle-box is fitted within that.
Patent GB-189815690-A (GB)
Title: Improvements in the Manufacture of Leather Hats and the like.
Inventor: DELLACHA GAETANO
Filed: 1898-07-18
Granted: 1898-10-08
Abstract: 15,690. Dellacha, G. July 18. Caps; helmets; materials, special.-Hats, helmets, caps, &c. are made from chrome or like mineral-tanned leather stretched, moulded, pressed, or ironed while in a moist state into the form desired. Either light skins or split leather may be employed.
Patent GB-189824160-A (GB)
Title: Improvements in Rotary Cutting Machines for Cardboard, Paper, and the like.
Inventor: STEVENSON ALBERT HUGH
Filed: 1898-11-16
Granted: 1899-09-23
Abstract: 24,160. Stevenson, A. H. Nov. 16. Cutting-machines for cardboard, paper, &c. -In cutting up cardboard, paper, &c. on rotary machines, the sheets are often not severed, but are cut partially through and separated at a l a t e r stage. Instead of using a circular cutter so set as to cut nearly through the material, a pair of rotary shearing - d i s c s are employed with notches in one or both of them so that small portions of uncut material are left at intervals. The notches may be made in both discs, as shown at 5, 5, Fig. 1, or in one of the discs only.
Patent GB-189901670-A (GB)
Title: Improvements in Motors Actuated by Gases under High Pressure.
Inventor: WHITE LEWIS BOYD
Filed: 1899-01-24
Granted: 1899-05-06
Abstract: 1670. White, L. B. Jan. 24. Compressed - gas e n g i n e s.-T h e engine is designed to be worked by gases under a very high pressure, such as liquefied or compressed carbonic acid. It has three double-acting cylinders A with inlet beat valves K and exhaust piston valves G. The two exhaust valves of one cylinder are joined together, and are operated by the lever I' worked from the piston B ; they close just before the end of the backstroke, in order to cushion the pistons. The inlet valves are operated by a rotating cam shaft J acting through levers T, and are opened after the pistons have begun their out-strokes. The cams S, S' on the shaft J, Figs. 7 and 8, are so constructed that, by moving the rod P longitudinally inside of the shaft J, the cam surfaces R, R<1> on it force one of the cams S, S' radially outwards to any desired extent, and withdraw the other out of action, thus enabling the engine to be reversed and controlling its power. The gas reservoirs N communicate with the inlet valve chambers and with each other. The cylinders are all bored out of one solid block of metal, and the covers A<3> and the plate A' carrying the valves are attached to it.
Patent GB-189902714-A (GB)
Title: An Instrument for Ascertaining or Indicating the Shape of the Wearing Surface of Tram Rails or other Surfaces Subject to Wear or being Operated upon.
Inventor: EDGE FREDERIC JAMES
Filed: 1899-02-07
Granted: 1899-12-09
Abstract: 2714. Edge, F. J., and Mangnall, W. Feb. 7. Gauge, adjusting.-Relates to an instrument for ascertaining the wear of the surface of tram rails &c. A number of slides b of equal length are guided in a box a by cross-wires d, d passing through slots c, which is placed over the surface to be gauged. The slides drop down into the irregularities of the surface, and the corresponding contour x, x, x at the top of the slide can be traced or photographed. e is a clamping-plate tightened by screws f. A pair of swivelling-legs, not shown, are provided on which the apparatus can rest when out of use, these can be turned along the ends of the instrument and secured by a pin and screw.
Patent GB-189907473-A (GB)
Title: Novel or Improved Appliance for Fixture to the Handle Bar or other Portion of a Cycle, Motor Car, or other Vehicle, to Facilitate the Striking of Matches.
Inventor: HART FRANK
Filed: 1899-04-10
Granted: 1899-05-20
Abstract: 7473. Hart, F., and Plant, W. H. April 10. Motor road vehicles.-A striking-plate b for matches is formed with or fixed to a clip A, so that it can be attached to the handle-bar &c. The clip is fitted with a clamping-screw c and nut e, and the plate b is roughened and preferably grooved as shown.
Patent GB-189912999-A (GB)
Title: Improvements in Burning and Drying Kilns or Furnaces.
Inventor: WEIJERS HENRI FRANS JOSEPH
Filed: 1899-06-22
Granted: 1899-08-05
Abstract: 12,999. Wefjers, H. F. J. June 22. Kilns.-Relates to burning and drying kilns in which a drying-chamber is situated between two rows of burning-chambers. The smoke-gases from the burning-chambers in which firing is taking place are conducted through pipes at the base of the drying-chamber, and the air which is drawn through the chambers which are burnt out and cooling down is conducted to the drying-chamber at the discharge end, and, after rising through the goods to be dried, it falls and is reheated by contact with the pipes, which also radiate heat to assist the drying process. The smoke-gases are first led to the flue n, and then descend a flue at one end to the pipes d. The air from the chambers undergoing cooling is conveyed by the pipe m and vertical flues as shown to the drying-chamber.
Patent GB-189915594-A (GB)
Title: A Process for the Production of Capsules, Cases, and the like, and Apparatus therefor.
Inventor: FRANK SALOMON
Filed: 1899-07-29
Granted: 1900-06-30
Abstract: 15,594. Frank, S. July 29. Squirting. - Capsules, cartridge cases, sockets, boxes, &c. are formed from copper, aluminium, zinc, or other metal by placing a disc of metal c in a die a with a false bottom b and acting on it with a pressure piston d till the metal occupies the cylindrical space between the piston and the die to form the required article, such as a flanged cartridge case, Fig. 4, or a capsule, Fig. 1. The aperture b<1>, Fig. 1, below the false bottom allows both the bottom and the article to be knocked out.
Patent GB-189915919-A (GB)
Title: Improvements in or connected with Means for Securing Rails to Sleepers, and in Rail Joints.
Inventor: SCHMIDT ALBERT EDUARD
Filed: 1899-08-03
Granted: 1900-06-02
Abstract: 15,919. Schmidt, A. E. Aug. 3. Rails, securing to sleepers; chairs; sleepers; rail joints.-The bolts b are not passed through the sleeper, but lie between two closely-adjacent sleepers e made suitably smaller. The rails lie on plates c, which may be wedge-shaped and ribbed as shown and are secured by the clamps a, bolts b, and plates f, which take under the sleeper. These plates f may bear ribs g. The plates c may bridge adjacent sleepers to support the joints.
Patent GB-190003617-A (GB)
Title: Improvements in Devices for Holding Ladies' and Children's Hats and Bonnets in Trunks, Boxes, Cupboards, and the like.
Inventor: ELLIS GEORGE BELOE
Filed: 1900-02-23
Granted: 1900-03-31
Abstract: 3617. Ellis, G. B., [Lippold, G. L.]. Feb, 23 Hat holders.-Relates to means for holding ladies' and children's hats and bonnets in trunks, boxes, cupboards, &c. The hat is pinned to a velvet-covered support a, made of metallic web of suitable elasticity. The free edge of the support is provided with a metallic riug b, from which project horizontal arms c. When in use, the support a is compressed, and two of the arms c are passed beneath loops e secured to the wall of the trunk, box, cupboard, &c., or to a bar d, which may be fixed or removably secured in the trunk &c.