baber/WOPTO huggingface dataset:
Patent CA-2423884-A1 (CA)
Inventor: ZENONI MAURIZIO
IPC: A61K31/337
Filed: 2003-03-28
Abstract: Antitumor formulation based on nanoparticles of paclitaxel and human serum al-bumin as obtained by the addition of a biocompatible acid to an aqueous albumin solution before this is mixed with paclitaxel during the nanoparticle production process, the injectable solutions of this formulation having a pH between 5.4 and 5.8 and having stability and inalterability with time.
Patent CA-2426062-A1 (CA)
Title: Method of determining prion strain
Inventor: PRUSINER STANLEY B
IPC: G01N33/531
Filed: 2001-09-21
Abstract: The present invention provides assays for identifying the levels of both protease sensitie and protease resistant conformers of PrPSc in a sample. In a preferred embodiment, the assay comprises determining levels of total PrPSc in a sample, subjecting the PrPSc fraction to treatment with a protease that selectively hydrolyzes the protease snesitive PrPSc (sPrPSc) conformers, and quantifying the elvels of sPrPSc in the sample. The ability to detect sPrPSc allows early detection of prions, since the PrPSc in easily accessible biological samples such as blood is predominantly sPrPSc. The ratio of sPrPSc to rPrpSc also allows the identification of a particular prion strain in an infected sample.
Patent CA-2429311-A1 (CA)
Inventor: MIGNANI SERGE
IPC: A61P31/00
Filed: 2001-11-14
Abstract: Dérivés hétérocyclylalcoyl pipéridine de formule générale (I) pour lesquels:  X1, X2, X3, X4 et X5 sont >C-R'1 à >C-R'5 ou bien l'un au plus représe nte N, R2 est COOH, alcoyloxycarbonyle, cycloalcoyloxycarbonyle, CN, -CONRaRb ou R2  est CH2OH, alcoyle substitué ou R2 est -CF2-Rc, -C(CH3)2-Rc, -CO-Rc, -CHOH-R c, -C(cycloalcoyle)-Rc ou -CH=CH-Rc, R3 est phényle, hétérocyclyle, alk-R~3, Y représente >CH-Re ou un radical difluorométhylène, carbonyle, hydroxyiminométhylène, alcoyloxyiminométhylène, cycloalcoyloxyiminométhylène , ou un radical cycloalcoylène-1,1, et n = 0 à 4 étant entendu que les radicau x ou portions phényle ou hétérocyclyle mentionnés ci-dessus peuvent être éventuellement substitués, sous leurs formes énantiomères ou diastéréoisomèr es ou les mélanges de ces formes, et/ou le cas échéant sous leur forme syn ou anti ou leur mélange ainsi que leurs sels.
Patent CA-2431220-A1 (CA)
Title: Indirector light fixture
Inventor: RUSSELLO THOMAS
IPC: F21S8/00
Filed: 2003-06-04
Abstract: An indirector light fixture is described wherein the fixture is comprised of a reflector housing and a ballast housing connected together by a support arm. The reflector housing may be positioned relative to the ballast housing by movement of the support arm and maintained therein by a ratchet and pawl mechanism or other rotational restriction device. The ballast housing and ballast electronics are connected to the lamp within the reflector housing by ballast feed wires which are maintained internal of the entire fixture thereby preventing the wires from becoming entangled during installation or after installation. Additional structure is provided to further allow adjustment of the head angle relative to the ballast housing.
Patent CA-2433419-A1 (CA)
Title: A method for producing a population of homozygous stem cells having a pre-selected immunotype and/or genotype, cells suitable for transplant derived therefrom, and materials and methods using same
Inventor: YAN WEN LIANG
IPC: C12N5/073
Filed: 2002-01-02
Abstract: A method of producing a homogenous population of homozygous stem (HS) cells pre-selected for immunotype and/or genotype from donor cells is described herein. The invention relates to methods of using immunohistocompatible HS  cells for diagnosis, therapeutic and cosmetic transplantation, and the treatment of various genetic diseases, neurodegenerative diseases, traumatic injuries and cancer. The invention further relates to methods for using histocompatible HS stem cells pre-selected for a non-disease genotype for prophylactic and therapeutic intervention including, but not limited to, therapeutic and cosmetic transplantation, and the treatment of various genetic diseases, neurodegenerative diseases, and cancer. Furthermore, the invention relates to a catalogued transplant depository of HS cells derived from multiple donors, each of the HS cells being homozygous for a unique HLA  haplotype, for the purpose of having a constant, reliable, comprehensive supply of immunohistocompatible cells for diagnosis, treatment and/or transplantation.
Patent CA-2439136-A1 (CA)
Inventor: DUTTA RABINDRANATH
IPC: G06F17/30
Filed: 2001-12-19
Abstract: A method is provided for reformatting a web page that includes a number of hyperlinks. The page is received (814) by a browser, and before being presented is analyzed (826) to determine whether the hyperlinks meet vertical and horizontal spacing criteria. If the page is cluttered with hyperlinks (826), it is reformatted (830) and then presented (818). The reformatting may be done by introducing HTML tags (830) or using a cascading style sheet (928).  Reformatting may also be done in response to a request submitted by a user (712) to the browser (708), to improve the appearance of the displayed web page.
Patent CA-2439265-A1 (CA)
Title: Composes d'imides succiniques cycliques accoles et leurs analogues, modulateurs de la fonction du recepteur d'hormones nucleaires
Inventor: MARTINEZ ROGELIO L
IPC: A61P25/28
Filed: 2002-02-20
Abstract: La présente invention concerne des composés cycliques accolés, des procédés d'utilisation de tels composés dans le traitement des conditions pathologiques associées au récepteur d'hormones nucléaires telles que le cancer et les troubles immunitaires, et des compositions pharmaceutiques contenant de tels composés.
Patent CA-2439389-A1 (CA)
Inventor: MUTO YASUFUMI
IPC: G02B6/32
Filed: 2003-09-03
Abstract: An optical module includes an optical fiber array and a lens array. An optical signal is mutually transmitted between the optical fiber array and the lens array. The optical fiber array and the lens array are secured to each other in a state in which the optical fiber array and the lens array are aligned with each other. An optical path is formed between the optical fiber array and the lens array to permit the optical signal through. A hollow spacer is located between opposing surfaces of the optical fiber array and the lens array. A hollow portion is formed in the hollow spacer. The size of the hollow portion is large enough so that the hollow spacer does not interrupt the optical path. The hollow spacer is adhered to the optical fiber array and the lens array to secure the optical fiber array and the lens array.
Patent CA-2439453-A1 (CA)
Inventor: PETERS VOLKER
IPC: H04H60/31
Filed: 2002-02-27
Abstract: An anti-plugging oscillating shear valve system for generating pressure fluctuations in a flowing drilling fluid comprising a stationary stator and an oscillating rotor, both with axial flow passages. The rotor (103) oscillates in close proximity to the stator (102), at least partially blocking the flow through the stator and generating oscillating pressure pulses. The rotor passes through two zero speed positions during each cycle, facilitating rapi d changes in signal phase, frequency, and/or amplitude facilitating enhanced data encoding. The rotor is driven by an electric motor (104) disposed in a lubricant filled housing (108). In one embodiment, the housing to shaft seal is a flexible bellows (107). In one embodiment, a torsional spring (105) is attached to the motor and the resulting spring mass system is designed to be near resonance at the desired pulse frequency. The torsion spring may be a solid torsion bar or a magnetic spring.
Patent CA-2441565-A1 (CA)
Title: Bisarylamines as potassium channel openers
Inventor: MCNAUGHTON-SMITH GRANT A
IPC: C07D401/12
Filed: 2002-03-15
Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides bisarylamines, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-relate d memory loss, learning deficiencies, anxiety and motor neuron diseases) and a s neuroprotective agents (e.g., to prevent stroke and the like) by opening potassium channels associated with the onset or recurrence of the indicated conditions.
Patent CA-2443566-A1 (CA)
Inventor: TRYBULSKI EUGENE JOHN
IPC: C07D487/04
Filed: 2002-04-11
Abstract: La présente invention concerne des composés de carboxamide tricyclique, ainsi que des procédés et des compositions pharmaceutiques utilisés pour traiter et/ou prévenir et/ou supprimer des troubles susceptibles d'être guéris ou soulagés par une activité antagoniste de l'ocytocine, y compris pour prévenir et/ou supprimer le travail avant terme, supprimer le travail à terme avant un accouchement par césarienne et pour traiter la dysménhorrée. Les composés de l'invention sont également utilisés pour augmenter les taux de fertilité, les taux de survie, pour synchroniser les chaleurs chez les animaux d'élevage, et ils peuvent être utilisés pour prévenir et traiter les dysfonctionnements du système à ocytocine dans le système nerveux central, y compris les troubles obsessionnels compulsifs (TOC) et les troubles neuropsychiatriques.
Patent CA-2443974-A1 (CA)
Title: Dispositif faisant office de lit a barreaux pour enfant
Inventor: TEUFEL RAINER B
IPC: A47D7/02
Filed: 2002-04-24
Abstract: La présente invention se rapporte à un dispositif (2) combinant les fonctions de lit à barreaux et de chaise haute permettant respectivement de maintenir un enfant en position d'inclinaison et en position assise. Ledit dispositif (2) comprend une plate-forme (16) présentant une extrémité côté tête, une extrémité côté pieds et généralement des côtés parallèles. Des rails latéraux (8, 10) sont disposés en position adjacente aux côtés. Des rails d'extrémité (12, 14) sont disposés en position adjacente aux extrémités de la plate-forme (16). Un siège (26) est orienté de manière à être adjacent à l'une des extrémités de la plate-forme (16). Ce siège (26) est disposé vers l'extérieur à partir de ladite extrémité. Une base (20) est couplée à la plate-forme (16) et au siège (26).
Patent CA-2448687-A1 (CA)
Title: Dispositif a main pour l'application d'un film, par exemple, de colle, de revetement ou de materiau colore a partir d'un ruban de support sur un substrat
Inventor: SCHNEIDER ROLAND
IPC: B65H37/00
Filed: 2002-06-19
Abstract: La présente invention concerne un dispositif à main (1) destiné à l'application d'un film (F) à partir d'un ruban de support (7) sur un substrat (8), ledit dispositif comprenant un logement (2) dans lequel sont disposés une alimentation en ruban de support (7) et un dispositif d'extraction (12) du ruban de support (7) et un organe d'application (4) faisant saillie à partir du logement (2) avec une réglette d'application (4a) et relié en pivotement à une base d'application (6) portée au niveau du logement (2) autour d'un axe de pivotement (5c) s'étendant transversalement à la réglette d'application en saillie (4a), dans lequel l'organe d'application (4) possède deux jambes de support (35) disposées à une distance (a) du bord d'application (4b) et définissant un plan de butée (E2) avec le bord d'application (4b) qui est en butée sur le substrat (8) lors du fonctionnement du dispositif portable (1). En vue d'améliorer les caractéristiques de l'organe d'application, le joint (5) est aménagée dans la saillie sur le plan de butée (E2) entre les jambes de support (35) et le bord d'application (4b).
Patent CA-2452479-A1 (CA)
Inventor: COSSE FRANCOIS
IPC: C22C21/02
Filed: 2002-07-09
Abstract: The invention concerns a safety or structural part cast under pressure made of high-ductility aluminium alloy consisting of (in wt. %): Si 2-6; Mg < 0.40; Cu < 0.30; Zn < 0.30; Fe < 0.50; Ti < 0.30, at least an element for reducing adherence on the mould such as Mn (0.3-2%), Cr (0.1-0.3), Co (0.1-0.3), V (0.1-0.3) and Mo (0.1-0.4), and at least an element modifying eutectics, such as Sr (50-500 ppm), Na (20-100 ppm) and Ca (30-120 ppm); other elements < 0.05 each and < 0.10 in total, the balance being aluminium exhibiting, after T5 tempering at a temperature less than 220 ·C, a yield strength R¿p0.2? > 110 MPa and an elongation A > 10 %.
Patent CA-2453428-A1 (CA)
Title: Canaux ioniques vegetaux et methodes
Inventor: KINNERSLEY ALAN M
IPC: C12P21/02
Filed: 2002-07-19
Abstract: L'invention concerne des protéines réceptrices végétales recombinantes, ainsi que des séquences de nucléotides codant ces protéines. Cette invention a également trait à des vecteurs recombinants englobant les séquences de nucléotides codant lesdites protéines. En outre, cette invention porte sur des cellules hôtes végétales qui comprennent les vecteurs recombinants, des végétaux transgéniques et des méthodes d'utilisation des séquences d'acides aminés et de nucléotides susmentionnées, notamment des méthodes de traitement de végétaux, des méthodes d'expression des protéines susmentionnées, des méthodes de modification de l'activité réceptrice chez un végétal et des méthodes de régulation du métabolisme végétal. Les protéines réceptrices de cette invention sont sensées fonctionner comme des modulateurs efficaces des effets de GABA.
Patent CA-2456567-A1 (CA)
Inventor: RIDEOUT KEITH LINCOLN
IPC: B42F7/00
Filed: 2004-03-01
Abstract: The presentation folder is made up from a pre-designed die-cut on the desired stock of paper, forming the edges, scores, window and slits. Die-cutting uses sharp steel rules to cut or score (crease to facilitate folding) special shapes for labels, boxes or containers from printed sheets on a press. Special components include: -the business card is held into place by two horizontal curved ~S'- shaped slits that fit securely to the left and right edges of the card. -the business card viewing window on the front panel is aligned with the business card on the inside. -an extended back panel and tab are folded along the score: upwards and to the inside, and the tab is glued, producing the pocket. Along with an imprinted customer logo (optional placement), this produces a stylish organization tool that exhibits proficiency for the company.
Patent CA-2456920-A1 (CA)
Title: Removal of contaminants from a lipophilic fluid
Inventor: BURTON DEWEY EDWARD
IPC: B01J20/32
Filed: 2002-09-10
Abstract: The present invention relates to processes for removing contaminants from lipophilic fluids, adsorbent materials employed in such processes, and lipophilic fluids produced by such processes.
Patent CA-2457019-A1 (CA)
Inventor: TAYLOR JEAN
IPC: A61B17/56
Filed: 2002-08-08
Abstract: The invention concerns an assembly comprising: a rear damping implant (10), configured to be laterally placed at the blade-spinal junction of two vertebrae (2, 3) treated without resection of the supra-spinal rear ligament (5), said implant (10) having a height such that, when set in place, it enables, to reset the supra-spinal rear ligament in anatomical tension; and at least a damping interbody implant (11), configured to be inserted between the vertebral end-plates of the two treated vertebrae (2, 3), by the same path used during dissectomy, said implant (11) having a height such that, when set in place, it enables to restore the anatomical height of the intervertebral disc (4) and to reset the front common ligament in anatomical tension.
Patent CA-2459140-A1 (CA)
Inventor: KHARE REENA
IPC: C12N5/10
Filed: 2002-09-13
Abstract: Différents modes de réalisation de cette invention portent sur des molécules de maintenance et de modification de protéines (PMMM) humaines et sur des polynucléotides qui identifient et codent ces molécules PMMM. Certains modes de réalisation de cette invention concernent également des vecteurs d'expression, des cellules hôtes, des anticorps, des agonistes et des antagonistes. D'autres modes de réalisation concernent des méthodes de diagnostic, de traitement ou de prévention de troubles associés à l'expression aberrante des molécules PMMM.
Patent CA-2459180-A1 (CA)
Title: Multi-bit delta-sigma analog-to-digital converter with error shaping
Inventor: COSAND ALBERT E
IPC: H03M3/02
Filed: 2002-07-05
Abstract: A quantizer adapted for use with a delta-sigma analog-to-digital converter.  The quantizer includes first and second comparators adapted to compare an input analog signal to a threshold and provide a digital output in response thereto. First and second thresholds are provided to the first and second comparators respectively. In accordance with the present teachings, a mechanism is provided for changing the thresholds to minimize conversion errors. While the mechanism for changing the thresholds may be implemented with resistive and/or capacitive ladders, in the illustrative embodiment, digital-to-analog converters are utilized. The DACs are driven by error shaping logic. The inventive quantizer allows for an improved delta-sigma analog-to-digital converter design which combines an ADC and a DAC. The DAC  reconstructs the analog equivalent of the digital output of the ADC. The ADC  is a flash converter consisting of one comparator per threshold. The DAC  operates by summing the outputs of a set of nominally identical unit elements.  The DAC has the same number of elements as there are comparators in the flash ADC and each comparator drives one element of the DAC. A novel feature is that the thresholds of the comparators in the ADC can individually be dynamically adjusted, so that the correspondence between an element of the DAC and a particular threshold of the ADC can be varied from sample to sample under the control of logic circuitry. This arrangement allows the correspondence between DAC elements and ADC thresholds to be remapped without introducing any additional delay into the signal path between the ADC and the DAC. In a high speed continuous-time delta sigma modulator, this allows randomization or shaping of the mismatch errors of the DAC elements to be achieved without incurring any penalty in sample rate, nor adding any excess delay into the loop that might destabilize or otherwise degrade the operation of the modulator.
Patent CA-2460137-A1 (CA)
Title: Digital options having demand-based, adjustable returns, and trading exchange therefor
Inventor: LANGE JEFFREY
IPC: G06Q50/00
Filed: 2002-09-09
Abstract: Methods and systems for conducting demand-based trading are described. In one embodiment, states are established, each state corresponding to at least one possible outcome of an event of economic significance. An investment amount may be determined as a function of a selected outcome, a desired payout, and a total amount invested in the states. In another embodiment, an investment amount may be determined as a function of parameters of a financial product.  In another embodiment, a payout may be determined as a function of an investment amount, a selected outcome, a total amount invested in the states, and an identification of a state corresponding to an observed outcome of the event.
Patent CA-2462544-A1 (CA)
Inventor: FREY PAUL DEWITT
IPC: A61B1/005
Filed: 2002-09-17
Abstract: A steerable endoscope (100) has an elongated body (102) with a selectively steerable distal portion (104) and an automatically controlled proximal portion (106). The endoscope body is inserted into a patient and the selectively steerable distal portion (104) is used to select a desired path within the patient's body. When the endoscope body is advanced, an electronic motion controller (140) operates the automatically controlled proximal portion (106) to assume the selected curve of the selectively steerable distal portion (104). Another desired path is selected with the selectively steerable distal portion and the endoscope body is advanced again. As the endoscope body is further advanced, the selected curves propagate proximally along the endoscope body, and when the endoscope body is withdrawn proximally, the selected curves propagate distally along the endoscope body. The creates a serpentine motion in the endoscope body allowing it to negotiate tortuous curves along a desired path through or around and between organs within the body.
Patent CA-2463253-A1 (CA)
Inventor: WOBBEN ALOYS
IPC: F03D1/00
Filed: 2002-09-24
Abstract: The invention relates to a method for establishing a foundation for a buildi ng comprising several segments, in particular for a tower (2) of a wind energy plant, a foundation segment for use in such a method and wind energy plant. According to the invention, a stable foundation may be achieved whereby a method with the following method steps is disclosed: excavating a foundation bed (13), production of a stable essentially flat and horizontal-running granular sub-base (12) in the foundation bed (13), placement of a foundation segment (4) of the building on the granular sub-base (12), whereby at least three height-adjustable support rods (11, 21) are fixed to the foundation segment (4), by means of support feet (110) on the end of each support rod (11, 21), such that only the support rods (11, 21) are placed on given suppo rt points (14) of the granular sub-base (12), production of reinforcing on the granular sub-base and casting what remains of the foundation bed with foundation masses, in particular, concrete up to above the lower edge of the foundation segment (4).
Patent CA-2463641-A1 (CA)
Title: Antisense antiviral agent and method for treating ssrna viral infection
Inventor: SKILLING DOUGLAS E
IPC: A61P31/14
Filed: 2002-10-16
Abstract: This invention provides antisense antiviral compounds and methods of their u se in inhibition of growth of viruses of the picornavirus, calicivirus, togavir us and flavivirus families, as in treatment of a viral infection. The antisense antiviral compounds are substantially uncharged oligomers having a targeting base sequence that is substantially complementary to a viral target sequence which spans the AUG start site of the first open reading frame of the viral genome.
Patent CA-2464203-A1 (CA)
Title: Layered cereal bar with thixotropic filling and methods of making same
Inventor: FUNK DEAN F
IPC: A23L7/122
Filed: 2004-04-13
Abstract: A layered cereal bar with at least two cereal layers having identifiable RTE cereal pieces and at least one visible filling layer in between the two cereal layers is described. In one embodiment, the cereal bar is a non- cooked cereal bar having a total nutrient level equal to or greater than the nutrient level of a single serving of RTE cereal with milk. In one embodiment, the cereal layer is comprised of a cereal composition containing RTE cereal, high-protein rice pieces and TVP in a ratio of about 2:1:1. The cereal layer further comprises a binder to hold the cereal composition together. In one embodiment, the filling layer is a confectionery center that is high in milk content, but possesses a relatively low water activity. In one embodiment, the filling layer is a low water activity fruit filling layer. In another embodiment, a method for manufacturing a layered cereal bar having a visible filling layer is described. The steps include mixing a binder with a cereal composition having identifiable cereal pieces to form an amorphous mass, compressing the amorphous mass into a first layer and a second layer, applying a filling layer on the first layer, combining the first layer and filling layer with the second layer, and pressing the first layer, filling layer and second layer together to form pressed layers, wherein the pressed layers are cut into individual cereal bars having identifiable cereal pieces.