baber/WOPTO huggingface dataset:
Patent CA-3130645-A1 (CA)
Title: Cell penetrating transposase
Inventor: HUDECEK MICHAEL
IPC: C12N15/90
Filed: 2020-02-19
Abstract: The Sleeping Beauty (SB) transposon is an efficient non-viral tool for inserting transgenes into cells. Its broad utilization in gene therapy has been hampered by uncontrolled transposase gene activity and the inability to use transposase protein directly. The present invention concerns the finding that SB transposase spontaneously penetrates mammalian cells and can be delivered with transposon DNA to gene-modify various cell lines, embryonic, hematopoietic and induced pluripotent stem cells. The invention provides methods and compounds to apply the cell penetrating function of transposase in methods of genetically engineering cells as well as using the transposase as a shuttle for delivering cargo into a target cell or even into a target cell organelle. Genomic integration frequency can be titrated using the technology of the invention, which adds an additional layer of safety, opening opportunities for advanced applications in genetic engineering and gene therapy.
Patent CA-3131124-A1 (CA)
Inventor: HAWKSLEY STEVEN
IPC: C02F1/00
Filed: 2019-11-20
Abstract: A water filtration system is also disclosed. The water filtration system includes a regenerative media filter vessel, a filtrate line, a feed line, a recirculation line, a gas line, and at least one pump. A method of filtering water in a system comprising a regenerative media filter is disclosed. The method includes operating the system in a filtration mode, operating the system in a cleaning mode responsive to a differential pressure measurement across the regenerative media filter, operating the system in an aeration mode, operating the system in a pre-filtration mode after operating the system in the cleaning mode, operating the system in a drain mode, and operating the system in the filtration mode following the drain mode. A controller and non-transitory computer-readable medium having computer-readable signals stored thereon that define instructions that, as a result of being executed by the controller, instruct the controller to perform a method of operating a water filtration system are disclosed.
Patent CA-3135348-A1 (CA)
Title: Procede de conditionnement d'une electrode selective d'ions
Inventor: HUTTER TANYA
IPC: G01N27/333
Filed: 2020-03-25
Abstract: L'invention concerne un procédé de préparation/ pré-conditionnement/ conditionnement/ traitement d'une électrode sélective d'ions, ISE, pour une cellule d'électrode sélective d'ions. La cellule d'électrode sélective d'ions comprend l'ISE et une électrode de référence, RE. Le procédé comprend l'exposition de l'ISE et d'une seconde électrode à une solution comprenant l'ion, l'application d'une première différence de potentiel, PD, d'un premier ensemble de PD, ayant une certaine polarité, à travers l'ISE et la seconde électrode et l'application d'une première différence de potentiel, PD, d'un second ensemble de PD, ayant une polarité inverse, à travers l'ISE et la seconde électrode.
Patent CA-3135922-A1 (CA)
Title: Appareil d'alimentation electrique et reseaux associes
Inventor: TONG YUI LUNG
IPC: B60L53/62
Filed: 2020-04-29
Abstract: L'invention concerne un appareil d'alimentation électrique et un réseau d'alimentation électrique comprenant une pluralité d'appareils d'alimentation électrique en réseau en communication de données avec un contrôleur de réseau et en interconnexion de puissance. La pluralité d'appareils en réseau sont connectés en puissance de sorte qu'un appareil en réseau est configuré en tant que deuxième source d'énergie d'un autre appareil en réseau ou d'autres appareils en réseau, le contrôleur de réseau étant configuré pour collecter des informations d'état de charge de chaque appareil membre du réseau, pour appliquer des options de vitesse de charge disponible à chaque appareil en réseau pour la sélection par l'utilisateur, et pour sélectionner le principe de sortie de puissance en fonction de l'option de vitesse de charge sélectionnée et des informations d'état de charge.
Patent CA-3135971-A1 (CA)
Inventor: FREDENS JULIUS
IPC: C12N1/20
Filed: 2020-05-14
Abstract: The current invention provides a synthetic prokaryotic genome comprising 5 or fewer occurrences of one or more sense codons; and/or a synthetic prokaryotic genome derived from a parent genome, wherein the synthetic prokaryotic genome comprises less than 10%, 5%, 2%, 1%, 0.5%, 0.1% of the occurrences of one or more sense codons, relative to the parent genome; and/or a synthetic prokaryotic genome comprising 100 or more, 200 or more, or 1000 or more genes with no occurrences of one or more sense codons.
Patent CA-3137649-A1 (CA)
Title: An antigen-binding molecule, a pharmaceutical composition, and a method
Inventor: KOGA HIKARU
IPC: C07K16/18
Filed: 2020-05-14
Abstract: The present invention provides antigen-binding molecules that bind to C1s and comprise a heavy chain variable region, a light chain variable region and an Fc region, wherein (i) the heavy chain variable region and/or the light chain variable region comprise at least one amino acid that can increase the ratio of KD value of the antigen-binding molecule to C1s in acidic pH range to KD value of the antigen-binding molecule to C1s in neutral pH range, KD (acidic pH range)/ KD (neutral pH range), compared to that of the first reference antibody; (ii) the Fc region comprises at least one amino acid that can increase binding ability of the antigen-binding molecule to FcRn in acidic pH range compared to that of the second reference antibody; and (iii) the Fc region comprises at least one amino acid that can increase binding ability of the antigen-binding molecule to Fc? receptor in neutral pH range compared to that of the second reference antibody.
Patent CA-3137781-A1 (CA)
Title: System and method
Inventor: Schraub Martin
IPC: A61F2/16
Filed: 2020-04-24
Abstract: The present invention generally relates to a system for two-photon or multi- photon irradiating an artificial lens, preferably an intraocular lens preferably arranged within an eye of a patient and a method for locally adjusting a polarizability and/or a refractive index of an artificial lens preferably an intraocular lens preferably arranged within an eye of a patient. The method relates in particular to fabrication of optical profiles by adjusting polarizability through two- or multi-photon processes in a non-destructive manner.
Patent CA-3138682-A1 (CA)
Inventor: PETERS KEVIN
IPC: A61K31/426
Filed: 2020-04-28
Abstract: L'invention concerne des composés efficaces pour l'activation de Tie-2 et l'inhibition de HPTP-bêta. Ces composés peuvent constituer une thérapie efficace pour des affections oculaires, telles que la pression intraoculaire, l'hypertension oculaire et le glaucome.
Patent CA-3139696-A1 (CA)
Inventor: LAI NORMAN
IPC: H04N13/30
Filed: 2021-11-22
Abstract: Embodiments of an immersive augmented reality (AR) engine for delivery of multimedia content are disclosed. In an embodiment, the AR engine includes a processor and a memory storing computer-executable instructions that when executed, cause the processor to receive a multimedia content. The computer-executable instructions further cause the processor to gather one or more creative assets according to a blueprint and position the one or more creative assets in the received multimedia content, wherein the one or more creative assets form one or more visual layers in the received multimedia content. Further, the computer-executable instructions further cause the processor to synchronize a playback of the one or more creative assets in each of the one or more visual layers and then, recreate a depth-based multimedia content, wherein the depth-based multimedia is rendered including the synchronized one or more visual layers.
Patent CA-3139980-A1 (CA)
Inventor: CAMPBELL RICHARD V
IPC: E02F9/14
Filed: 2020-01-07
Abstract: A method and hardware for damping and controlling unwanted motion in the fixed rigging of large machines. In a first approach large clamp blocks are added to multi-cable rigging systems. These blocks use a first cable to damp the motion of an adjacent cable. The invention also encompasses adding armored sections to synthetic cables to enhance then- abrasion resistance and cut resistance.
Patent CA-3141841-A1 (CA)
Inventor: VAN DER UPWICH STIJN
IPC: B01D21/00
Filed: 2020-06-17
Abstract: L'invention concerne un dispositif de filtration destiné à éliminer des particules d'un fluide, le dispositif de filtration comprenant une chambre de fluide et une entrée pour le fluide, une sortie pour le fluide filtré et une sortie pour les particules, chacune étant couplée à la chambre de fluide, le dispositif de filtration comprenant en outre un mécanisme de direction d'écoulement pour induire un écoulement tourbillonnaire autour d'un axe de tourbillon dans ladite chambre de fluide, la sortie pour des particules étant couplée à la chambre de fluide à un emplacement sensiblement perpendiculaire à l'axe de tourbillon.
Patent CA-3143264-A1 (CA)
Title: Long-acting topical formulation and method of use thereof
Inventor: HEPLER DOUGLAS
IPC: A61K31/496
Filed: 2020-06-12
Abstract: Provided herein are long-acting, non-aqueous pharmaceutically acceptable compositions of active ingredients for topical administration.
Patent CA-3143861-A1 (CA)
Title: System and method for exchanging payment data between a cash register and a device for acquiring electronic payments
Inventor: NACCACHE DAVID
IPC: G06Q20/04
Filed: 2020-06-22
Abstract: The invention relates to a payment system comprising: an electronic cash register (10) associated with a physical point of sale of a merchant (M); and a payment acquisition device (20) for advantageously cooperating with a payment issuing device (30) of a client (C) via a first link (L1). Such a payment acquisition device (20) transmits payment transaction messages (MSGT) to a bank server (40) via a second link (L2) in order to implement electronic payment transactions. The payment acquisition device (20) is configured to comprise means (28) for capturing a view of any invoice (B) issued by an electronic cash register (10), and the processing unit (21) of such a payment acquisition device (20) is configured to trigger the capture of at least one digital representation (RN) of the invoice (B) and to automatically detect and determine therefrom the payment amount (MT) of the relevant financial transaction. Figure to be published with the abstract: Fig. 5
Patent CA-3144817-A1 (CA)
Inventor: RAHILLY MICHAEL
IPC: A61J7/00
Filed: 2020-06-26
Abstract: Les systèmes et les procédés de l'invention concernent un contenant ou un casier intelligent. Un ensemble contenant-casier comprend un corps de casier, un mécanisme de verrouillage et un dispositif de commande. Un procédé comprend la réception, par l'intermédiaire d'une interface de communication, d'une demande authentifiée pour accéder au contenant intelligent, l'actionnement d'un verrou électromécanique pour dégager un crochet de fixation, ce qui permet d'initier un mouvement mécanique d'un élément d'accès afin de rendre un compartiment interne accessible, la sortie, par l'intermédiaire d'un élément audiovisuel, d'une alerte pour identifier le contenant, la confirmation de remise en prise du verrou électromécanique avec le crochet de fixation, ce qui permet de sécuriser le compartiment interne, la détermination d'un changement dans un inventaire local, et la mise à jour l'inventaire local dans une mémoire de données non volatile selon le changement.
Patent CA-3148341-A1 (CA)
Inventor: CROOM ANNA K
IPC: A61K8/02
Filed: 2020-08-13
Abstract: A polyurethane elastomeric rubber composition containing a bio-based polyol cross-linked with a bio-based isocyanate using a urethanation catalyst such as a bismuth catalyst in the presence of a cosmetic emollient is disclosed. The cross-linked polyurethane elastomer rubber is in further aspect of the invention included in a gel after being milled in the presence of a bio-based emollient or mixture of bio-based emollients. The polyurethane elastomeric gel has good compatibility with cosmetic and natural oils and can be used as a gelling agent for these oils among other desirable cosmetic formulary roles.
Patent CA-3149176-A1 (CA)
Title: Process-scale synthesis of a plasma kallikrein inhibitor
Inventor: EL-KATTAN YAHYA
IPC: C07D231/14
Filed: 2020-08-05
Abstract: Disclosed are methods of preparing Compound (I), and salts thereof. The methods of preparing Compound (I) are suitable for use on process scale.
Patent CA-3149488-A1 (CA)
Inventor: WEIN NICOLAS SEBASTIEN
IPC: A61P21/00
Filed: 2020-08-03
Abstract: The disclosure relates to the field of gene therapy for the treatment of a muscular dystrophy including, but not limited to, Duchenne Muscular Dystrophy (DMD). More particularly, the disclosure provides nucleic acids, including nucleic acids encoding U7-based small nuclear ribonucleic acids (RNAs) (snRNAs), U7-based snRNAs, and recombinant adeno-associated virus (rAAV) comprising the nucleic acid molecules to deliver nucleic acids encoding U7-based snRNAs to induce exon-skipping for use in treating a muscular dystrophy including, but not limited to, DMD, resulting from a mutation amenable to skipping exon 44 of the DMD gene (DMD exon 44) including, but not limited to, any mutation involving, surrounding, or affecting DMD exon 44.
Patent CA-3151388-A1 (CA)
Title: Methodes de traitement de proteines animales
Inventor: NEBOUT JEAN-MICHEL
IPC: A23K10/20
Filed: 2020-09-30
Abstract: L'objet de la présente invention concerne des méthodes de traitement de protéines animales et des produits alimentaires pour animaux de compagnie les comprenant. Les méthodes comprennent le traitement de protéines animales avec un ou plusieurs composés de base pour augmenter leur pH pour permettre une conservation accrue et la réduction de l'altération de la protéine animale.
Patent CA-3151862-A1 (CA)
Inventor: BALLENDAT MARTIN
IPC: A47C7/44
Filed: 2020-08-18
Abstract: The invention relates to a chair (10), in particular to an office chair, comprising a pedestal (11), a base support (14) arranged on the pedestal, a seat element (15) arranged on the base support and a seat back (16), wherein the seat back has a backrest carrier (17) arranged on the base support and a backrest (18) arranged on the backrest carrier, the backrest carrier forming a spring apparatus (23), such that the backrest is movable laterally from a center position to a lateral position counter to a restoring force applied by means of the spring apparatus.
Patent CA-3152245-A1 (CA)
Inventor: CHUNG JUNHO
IPC: A61K39/00
Filed: 2020-09-23
Abstract: L'invention concerne un anticorps anti-MERS-CoV ou un fragment de liaison à l'antigène de celui-ci, et ses utilisations médicales.
Patent CA-3152277-A1 (CA)
Title: Ligne de trempe rapide
Inventor: GAENSBAUER DAVID ANTHONY
IPC: B21C47/18
Filed: 2020-10-13
Abstract: Une ligne de trempe rapide selon l'invention peut être apte à être utilisée avec une bobine chaude au niveau ou au-dessus du point de recristallisation de la bande métallique. La bobine chaude peut être déroulée par un dérouleur à faible tension à l'aide d'un dispositif de maintien sans contact. La bande métallique sortant de la bobine chaude est rapidement trempée (par exemple, à des vitesses supérieures ou égales à 100 °C/s ou 200 °C/s) à travers de multiples zones de trempe. Un liquide de refroidissement peut être éliminé, par exemple avec une lame d'air et/ou un racleur (par exemple, un racleur ultra-élastique). De la vapeur peut être collectée dans des zones de trempe antérieures et être reconvertie pour fournir de l'air humide à la bande métallique, notamment dans des régions où la température de la bande métallique est égale ou inférieure au point Leidenfrost. La bande métallique refroidie peut passer à travers une bride pour augmenter la tension dans la bande métallique avant que la bande métallique soit éventuellement lubrifiée, puis rembobinée ou autrement traitée.
Patent CA-3153328-A1 (CA)
Title: Method and composition for increasing muscle protein synthesis
Inventor: BELLAMINE AOUATEF
IPC: A61K31/205
Filed: 2020-10-16
Abstract: A method and composition for increasing muscle protein synthesis in mammals is disclosed. In one embodiment, the mammals are administered a protein building composition comprising at an amino acid derivative including L-carnitine and a nitrogenous organic acid including creatine. In a particular embodiment, the creatine is in an acid resistant capsule delivery form. The ratio of L-carnitine to creatine can be from about 10:1 to about 1:1. The protein building composition can be administered in a monolithic enteric capsule.
Patent CA-3153591-A1 (CA)
Title: Gift-transfer system
Inventor: SCHIMKE SCOTT A
IPC: G16Z99/00
Filed: 2017-12-07
Abstract: An aspect of the present invention includes a method for transferring a gift using a gift-tra nsfer application. A digital gift can be associated with a unique tag identifier on a gift item, and the unique tag identifier can be used to retrieve the digital gift. Specifically, the method includes associating the unique tag identifier with an electronic gift of a particular monetary value and using a payment portal to charge a financial account an amount equal to the monetary value. The method further includes the gift-transfer application receiving a request including the unique tag identifier to redeem the electronic gift and, in response, sending a plurality of value-allocation links along with respective options for applying the monetary value to an electronic gift card of a respective merchant.
Patent CA-3158621-A1 (CA)
Inventor: PAMPLIN RYAN MICHAEL
IPC: H02J7/00
Filed: 2020-10-06
Abstract: A rechargeable blender with offset blades is disclosed. Exemplary implementations may include a base assembly that includes a set of blades, a container assembly, control circuitry, and/or other components. The blender includes a set of blades that is offset from the center of the blade assembly such that the rotational axis of the set of blades does not intersect the vertical center line of the base assembly.
Patent CA-3160898-A1 (CA)
Inventor: ROLFS SUSAN EMILY
IPC: A47F10/00
Filed: 2022-05-13
Abstract: A lottery ticket dispensing method provides an inventory of lottery tickets in an automated dispenser, the inventory comprising lottery tickets for a plurality of different lottery games. Upon a player making a selection of a lottery ticket from the dispenser, with a controller in communication with the dispenser, one or more companion lottery games for the lottery ticket selected by the player are assigned from the different lottery games in the inventory based on predefined filter values.  The method verifies that the designated companion lottery games have lottery tickets available in the inventory and then presents one or more of the verified designated companion lottery games to the player as a suggestion or recommendation for an additional lottery ticket purchase.
Patent CA-3162595-A1 (CA)
Title: Powder formulation for ingredient dispersion
Inventor: GULYAS MICHAEL
IPC: B01F23/50
Filed: 2022-06-13
Abstract: The present invention is a powder formulation designed to function as an insoluble ingredient disperser. The invention demonstrates the ability to improve water distribution, uniformity, and the texture of final preparations.    Its composition also provides faster hydration and dispersion of ingredients in primed mixtures and other existing ingredients. A delivery system assists with the hydration of insoluble, oil-based, or poorly dispersible ingredients and create a variety of emulsification solutions for easier and faster processing. The present invention also increases the expansion of extruded products. Varying amounts of the powder formulation can be added as needed to further improve the dispersion and uniformity of final preparations.
Patent CA-3164210-A1 (CA)
Inventor: BIJLSMA DENNIS RAYMOND
IPC: G16H20/13
Filed: 2022-06-17
Abstract: The invention relates to a device for filling a medicine-unit container for use in a medicine unit dispensing device, comprising a support for the container, adapted to fix the position of the container relative to the device and limit a movement of the container relative to the device and at least one movable push element, such as a rod or pin, operable relative to the support, for pushing an unlocking element of a container supported by the device.
Patent CA-3171579-A1 (CA)
Inventor: GREENBERG ADAM PHILLIP TAKLA
IPC: G06T7/80
Filed: 2021-03-19
Abstract: L'invention divulgue une infrastructure et des procédés de mise en ?uvre d'une plateforme pour une opération horticole. Des données de capteur sont reçues en provenance d'un ou de plusieurs capteurs configurés pour capturer des données pour des plantes à l'intérieur d'une opération de croissance de plante. Un accès est réalisé aux données accumulées, associées à d'autres plantes dans d'autres opérations de croissance des plantes. Les données sont analysées pour déterminer des conditions des plantes à l'intérieur de l'opération de croissance des plantes. Des actions de cultivateur de plantes pour améliorer la croissance des plantes sont déterminées. Des instructions sont transmises à un dispositif de commande associé à l'opération de croissance des plantes. Des produits ou des services agricoles associés aux actions de cultivateur de plantes sont déterminés. Un service d'échange agricole traite des informations de commerce électronique à partir de fournisseurs de produits ou de services. Les offres provenant des fournisseurs de services sont reçues et la sélection et l'exécution des offres sont facilitées.
Patent CA-3176801-A1 (CA)
Inventor: CUSHNER FRED
IPC: G16H40/67
Filed: 2020-06-06
Abstract: Medical devices coupled to a sensor, and systems including such devices, can generate data and analysis based on that data, which may be used to identify and/or address problems associated with the implanted medical device, including incorrect placement of the device, unanticipated degradation of the device, and undesired movement of the device. Also provided are medical devices coupled to a sensor, and devices and methods to address problems that have been identified with an implanted medical device.
Patent CA-3177010-A1 (CA)
Title: Solid-state polymer separator for lithium-ion batteries
Inventor: BUCUR CLAUDIU B
IPC: H01M10/0565
Filed: 2021-04-29
Abstract: A safe, thin and highly conductive solid-state polymer separator for lithium-ion batteries. The separator may be deployed in a battery which lacks solvent and allows lithium ions to pass through channels via the polymerized structure. The lithium conductive polymers may be formed through free radical polymerization and may comprise a lithium conductive polymer having a polymerized carbonate solvent between iterative spacers, a lithium conductive material, and a reinforcing additive. Optionally, an interface coating may reside on one or more sides of the separator to ensure long-term operation. By utilizing such a separator in a solid-state lithium battery, cell assembly may be simplified, shrinkage may be decreased and safety may be increased. Various methods of manufacturing the solid-state polymer separator for lithium-ion batteries are disclosed.
Patent CA-3177541-A1 (CA)
Inventor: MOGANTY SURYA
IPC: B01J41/14
Filed: 2020-05-05
Abstract: A solid polymer electrolyte including a cross-linked ionic liquid (IL) matrix having functional group capable of interacting with lithium ions; polymerizable PEM formulations containing polymerizable ionic liquid (IL) materials (monomers) having functional group capable of interacting with lithium ions and a reactive polymerizable functional group capable of crosslinking; electrolytes prepared from a polymerizable formulation including a lithium conducting salt, a plasticizer, a cross-linker, and a polymerizable IL compound that contains at least one functional group capable of interacting with lithium ions and a reactive polymerizable functional group capable of crosslinking; electrochemical cells containing the electrolytes incorporating these solid PEMs containing the polymerized ionic liquid (IL) materials; and methods thereof are disclosed.