baber/WOPTO huggingface dataset:
Patent IL-122637-A0 (IL)
Title: Use of CB2 receptor agonist compounds
IPC: A61K45/00
Filed: 1996-06-20
Abstract: The use of human CB2 receptor-specific agonists of formula (I) or (I') for preparing immunomodulating drugs is disclosed. In formulae (I) and (I'), R1 is a group selected from -CH2CHR10NR6R11, -(CH2)2NR'6R'11, -CHR9CH2NR'6R'11, -(CH2)nZ and -COR8; R'1 is a -CH2CHR10NR6R11 or -(CH2)2NR'6R'11 group; R2 and R'2 are hydrogen, halogen or C1-4 alkyl; R3 is hydrogen, C1-4 alkyl or a group selected from -CH2CHR10NR6R11, -(CH2)2NR'6R'11 and -COR8; R'3 is a =CR6R8 group; R4 has one of the meanings given for R5 or is a -COR8 group; R5 is hydrogen, C1-4 alkyl, C1-4 alkoxy, a halogen atom, a CF3 group, an OCF3 group or C1-4 alkylthio; R'5 has one of the meanings given for R5 and is in the 5 or 6 position of the indene ring; R6 is hydrogen or C1-4 alkyl; R'6 is C1-4 alkyl; R7 has one of the meanings given for R5 or R7 and R9 together form a -Y-CH2- group attached to the indole ring in the 7 position by a group Y; R8 is phenyl substituted one to four times by a substituent selected from halogen, C1-4 alkyl or C1-4 alkoxy; a polycyclic ring selected from naphth-1-yl, naphth-2-yl, 1,2,3,4-tetrahydronaphth-1-yl, 1,2,3,4-tetrahydronaphth-5-yl, anthryl, benzofuryl, benzothien-2-yl, benzothien-3-yl, 2-, 3-, 4- or 8-quinolyl, said polycyclic rings optionally being substituted once or twice by a substituent selected from C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, halogen, cyano, hydroxyl, trifluoromethyl and imidazol-1-yl; R10 and R11 together are a group selected from -CH2-O-CH2-CR12R13- and -(CH2)p-CR12R13-, wherein the carbon atom substituted by R12 and R13 is attached to the nitrogen atom; R'11 is C1-4 alkyl; or R'11 and R'6, taken together with the nitrogen atom to which they are attached, form a group selected from morpholin-4-yl, thiomorpholin-4-yl, piperidin-1-yl and pyrrolidin-1-yl; each of R12 and R13 is independently hydrogen or C1-4 alkyl; n is 2, 3, 4 or 5; p is 2 or 3; Z is a methyl group or a halogen atom; and Y is a methylene group or an oxygen atom.
Patent IL-126352-A0 (IL)
Title: Synthesis of solid powdery rare earth carboxylates by a precipitation method
IPC: C07C53/126
Filed: 1997-03-24
Abstract: The invention relates to the production of solid, powdery carboxylates of Rare Earth elements, particularly Nd, La, Pr, and Ce, where the ligands coordinated to the metal are preferably long chain, branched carboxylic acids, most preferably 2-ethylhexanoic, neodecanoic (versatic) and naphthenic acids. The process involves batch precipitation of the product by utilizing Rare Earth water soluble salts, preferably Rare Earth nitrates, and salts of the carboxylic acid and washing the product with water, alcohol, water and alcohol mixtures or combinations thereof.
Patent IL-141304-A0 (IL)
Title: A method for the preparation of c-4 deacetyltaxane derivatives and the enzyme for use therein
IPC: C12P15/00
Filed: 1999-08-03
Abstract: A process useful for the preparation of intermediates in synthesis or semi-synthesis of paclitaxel analogs wherein a starting taxane such as 10-deacetylbaccatin III is deacetylated at the C-4 position using a microorganism or an enzyme derived therefrom to provide 4-deacetyltaxanes, such as 4,10-dideacetylbaccatin III.
Patent IL-145298-A0 (IL)
Title: A process for the preparation of 1,4,7,10-tetraazacyclododecane
IPC: C07B61/00
Filed: 2000-03-06
Abstract: 1,4,7,10-Tetraazacyclodecane, a precursor for the synthesis of macrocylic chelating agents for metal ions such as gadolinium, is prepared efficiently as a highly pure product on an industrial scale.
Patent IL-154368-A0 (IL)
Title: Syringe comprising a cylinder receiving a liquid medium and having a closing cap
IPC: A61M5/28
Filed: 2001-08-01
Abstract: Syringe comprising a fluid medium holding barrel with a locking elements section and expansion sections on the outer surface and a sealing cap on the outlet of barrel, is new.
Patent IL-178243-A0 (IL)
Title: Scalable lossless audio codec and authoring tool
IPC: G10L19/00
Filed: 2006-09-21
Abstract: A multi-channel audio encoder for coding a digital audio signal sampled at a known sampling rate and having an audio bandwidth and blocked into a sequence of frames is provided and comprises: a core encoder (404) that extracts and codes a core signal from the digital audio signal into core bits; a packer that packs the core bits plus header information into a first bitstream; a core decoder (412) that decodes the core bits to form a reconstructed core signal; a summing node (420) that forms a difference signal from the reconstructed core signal and the digital audio signal for each of the multiple audio channels; a lossless encoder (424) that segments each frame of the multi-channel difference signals into a plurality of segments and entropy codes the segments into extension bits, said lossless encoder selecting a segment duration to reduce an encoded payload of the difference signals in the frame subject to a constraint that each segment must be fully decodable and less than a maximum size; and a packer (410) that packs the extension bits into a second bitstream.
Patent RO-125422-A0 (RO)
Title: Pharmaceutical composition based on plant extracts for treating hepato-biliary diseases and process for preparing the same
Inventor: MIRON GHIORGHI
IPC: A61P1/16
Filed: 2009-11-12
Abstract: The invention relates to a pharmaceutical composition used for treating hepato-biliary diseases and to a process for preparing the same. According to the invention, the composition comprises 15% of a mixture (A) consisting of essential oils of fur tree, pine, mint, orange, eucalyptus and sage, respectively, said essential oils being present in an amount of 18...22% in the mixture (A) and 85% of a mixture (B) consisting of 30...40% of oily extract of coniferous resin, 10...14% of milfoil oily extract, 45...55% of olive oil and 1...3% of buckthorn oil, the percentage being expressed by weight. According to the invention, the process consists in dosing the mixture (B) at a temperature of 30...40°C for 60 min, thereafter cooling down to a temperature of 20...25°C and adding, while stirring the mixture (A) in an amount of 15% from the total amount of the composition, while stirring continuously for 60 min, thereby resulting a product which is conditioned as solution or soft gelatin capsule.
Patent IE-910558-A1 (IE)
Title: Pharmaceutical compositions having depigmentating and¹antiphotoageing activity
IPC: A61K8/368
Filed: 1991-02-19
Abstract: The object of the present invention is a product based on a trans-retinoic acid (tretinoin) and azelaic acid combination having depigmentating effect and, more generally, antiphotoageing effect. After clinical and instrumental comparative analysis (clinical and photographic reports and skin mould profilometry), the action on physiological and/or photoinduced skin ageing obtained with the combination of the invention has been compared with the one noticeable after the treatment with azelaic acid or retinoic acid only. Better results were obtained using the azelaic-retinoic combination. The depigmentating action of the combination is superimposable to the one observed by using separately the two active ingredients, but it can be achieved in a surprisingly shorter time (from six to three months).
Patent IE-910681-A1 (IE)
Title: Clarifiers for polyolefins and polyolefin compositions containing same
Inventor: MILLNER O ELMO
IPC: C08L27/18
Filed: 1991-02-28
Abstract: Dibenzylidene xylonates are a new class of clarifiers for polyolefins. The invention includes polyolefin compositions having the new clarifiers therein.
Patent LU-84686-A1 (LU)
IPC: C21C5/46
Filed: 1983-03-11
Abstract: A method and apparatus for accelerating solid particles entrained in a carrier gas so as to maximize the velocity of the particles at the output end of a duct is presented. This maximized or optimal acceleration is achieved by varying the cross section of the duct over at least the last 5 meters upstream from the opening thereof. Preferrably, the cross section of the duct should continuously increase i.e. diverge, towards the opening. This diverging cross section is preferrably in accordance with a nonlinear function of the length.
Patent MA-23365-A1 (MA)
Inventor: JOHAN DEVENYNS
IPC: D21C9/10
Filed: 1994-11-04
Abstract: Process for bleaching a chemical pulp through a sequence of processing steps comprising, in this order, a step for decontaminating the pulp by removing its transition metals, an alcaline hydrogen peroxide processing step and a processing step using a non peroxygenated acid.
Patent MA-37590-A1 (MA)
Title: Procede de creation d'animations interactives en temps reel
Inventor: YOUNES MOUMEN
IPC: G06T13/20
Filed: 2014-11-28
Abstract: Un procédé basé sur le moteur graphique objet du brevet d'invention n° ma37544 pour la création d'animations interactives en temps réel. Le procédé commence par une étape de conception selon l'architecture spécifique du moteur graphique. Les données utilisateurs sont ensuite définies, puis les déclencheurs de messages et les fonctions de réponse. Ii faut ensuite implémenter les contrôleurs personnalisés si nécessaire. Une fois les étapes précédentes effectuées, il suffit de packager l'animation interactive pour exécutions dans |’environnement ciblé. C'est un procédé très simple qui bénéficie de l'architecture simplifiée du moteur graphique en question.
Patent MA-38830-A1 (MA)
Title: Procédé de préparation d'un produit laitier fermenté à teneur réduite en lactose et à propriétés nutritionnelles et organoleptiques améliorées
Inventor: RAMAGE OLIVIER
IPC: A23C19/076
Filed: 2016-02-05
Abstract: La présente invention concerne un procédé de préparation d'un produit laitier fermenté, le procédé comprenant les étapes suivantes : a) l'hydrolyse du lactose contenu dans le lait ; b) la concentration des protéines et des sucres par filtration de la composition résultante sous pression élevée ; une étape de fermentation du lait étant réalisée pendant l'étape a) ou après l'étape a) ou après l'étape b). L'invention concerne également un produit laitier fermenté pouvant être obtenu selon le procédé de l'invention.
Patent MA-39153-A1 (MA)
Title: Nouveaux composés hétérocycliques
Inventor: DESAI RANJIT
IPC: C07D487/04
Filed: 2015-02-02
Abstract: La présente invention concerne des composés hétérocycliques de formule générale (i), leurs sels pharmaceutiquement acceptables, solvates pharmaceutiquement acceptables, énantiomères, diastéréoisomères, et polymorphes. L'invention concerne également des procédés de préparation de ces composés, des compositions pharmaceutiques contenant ces composés, et leur utilisation en tant qu'inhibiteurs sélectifs de la tyrosine kinase de bruton (btk).(i)
Patent MA-44549-A1 (MA)
Title: Agents immunorègulateurs
Inventor: BALOG JAMES AARON
IPC: C07C13/16
Filed: 2015-11-05
Abstract: L'invention concerne des composés qui assurent la modulation de l'enzyme oxydo-réductase indoleamine 2,3-dioxygénase, ainsi que des compositions contenant ces composés. L'invention concerne également l'utilisation de tels composés et compositions dans le traitement et/ou la prévention d'un ensemble varié de maladies, troubles et affections, y compris de troubles liés au cancer et à l'immunité, à médiation par l'indoleamine 2,3-dioxygénase.
Patent UY-28590-A1 (UY)
Title: Procedimiento para la preparación de nuevas sales de tiotropio, nuevas sales de tiotropio como tales, así como las formulaciones medicamentosas que las contienen.
Inventor: SIEGER DR PETER
IPC: C07D451/10
Filed: 2004-10-29
Abstract: El invento se refiere a un procedimiento para la preparación de nuevas sales de tiotropio, a estas nuevas sales de tiotropio como tales, a las formulaciones medicamentosas que las contienen, así como a su utilización para la preparación de un medicamento para el tratamiento de enfermedades de las vías respiratorias, especialmente para el tratamietno de COPD (chronic obstructive pulmonary disease= enfermedades pulmonares crónicas obstructivas) y asma.
Patent UY-31136-A1 (UY)
Title: Oxazolidinonas sustituidas y su uso
Inventor: ANJA BUCHMULLER
IPC: C07D263/00
Filed: 2008-06-10
Abstract: La invención se refiere a nuevas oxazolidinas sustituidas, a procedimientos para su prparación, a su uso para el tratamiento y/o profilaxis de enfermedades así como a su uso para la preparación de medicamentos para el tratamiento y/o la profilaxis de enfermedades, de forma particular de enfermedades tromboembólicas.
Patent ES-177440-A1 (ES)
Title: MEJORAS EN O RELATIVAS A AMPLIFICADORES DE VALVULA TERMOIoNICA
IPC: H03F3/52
Filed: 1947-03-31
Abstract: Mejoras en amplificadores termoiónicos de alta frecuencia que emplean una o más válvulas pentodo, en los que un potencial alterno de entrada produce la aparición de un potencial alterno correspondiente en la placa de cualquier válvula pentodo determinada y también en algún otro punto en dicho amplificador, caracterizado en que la rejilla supresora de la válvula determinada está acoplada bien directamente o indirectamente a dicho otro punto en dicho amplificador a fin de modificar el efecto de la capacidad a tierra de dicha placa.
Patent ES-180391-A1 (ES)
Title: UN PROCEDIMIENTO DE FABRICACIoN DE PERLAS ARTIFICIALES
Filed: 1947-11-05
Abstract: Procedimiento de fabricación de perlas artificiales caracterizado porque se obtienen a partir de unos glóbulos o ánimas de vidrio huecas a las que se dota de un recubrimiento metálico brillante a base de plateado por reducción de una sal de plata disuelta generalmente nitrato siendo el agente reductor formaldehido u otro compuesto de propiedades análogas.
Patent ES-187532-A1 (ES)
Title: UN PROCEDIMIENTO O SUCESIoN DE OPERACIONES QUiMICAS PARA LA OBTENCIoN DE UN ENCáUSTICO A BASE DE D. D. T.
Filed: 1949-03-22
Abstract: Un procedimiento o sucesión de operaciones químicas para la obtención de un encáustico a base de DDT para pisos y muebles que se caracteriza porque partiendo de un encáustico obtenido por los procedimientos ordinarios se prepara una solución de DDT a base de difenil-dicloro-tricloroetano en polvo técnicamente puro mezclándolo con aguarrás o gasolina o jabón líquido neutro.
Patent ES-257608-A1 (ES)
Title: Improvements in or relating to nuclear-chlorinated aromatic compounds
IPC: C07C/
Filed: 1959-04-28
Abstract: Sodium hydroxylamine disulphonate, HON: (SO3Na)2, is produced, in aqueous solution, by adding an aqueous solution of sodium bisulphite to an aqueous solution of sodium nitrite, at a temperature a little below 0 DEG C., and then passing sulphur dioxide into the cooled solution until is shows an acid reaction. A solution of sodium hydroxylamine monosulphonate may be obtained by storing or heating a solution of the disulphonate. Specification 862,863 is referred to.ALSO:Beta-2, 6-dichlorobenzaldoxime is produced by reacting 2, 6-dichlorobenzaldehyde with an alkali metal salt of hydroxylamine mono- or disulphonic acid. This b - oxime is believed to be the geometric isomer of the oxime produced by the action of hydroxylamine on 2, 6-dichlorobenzaldehyde. The b -oxime may be converted directly into 2, 6-dichlorobenzonitrile, or the conversion may be carried out via the acetyl derivative of the oxime. In Example 1, an ethanolic solution of 2, 6-dichlorobenzaldehyde is added to an aqueous solution of sodium hydroxylaminedisulphonate, and the mixture is heated at 75 DEG C. for 30 minutes whereby crystalline b -2, 6-dichlorobenzaldoxime is formed. The oxime is acetylated by heating, at about 85 DEG C., with acetic anhydride and the acetyl derivative is treated with pyridine whereby 2, 6-dichlorobenzonitrile is produced. In Example 2, the nitrile is obtained directly from the oxime by boiling it with acetic anhydride. In Examples 3 and 4, the nitrile is produced by reacting the oxime with thionyl chloride and phosphorous oxychloride, respectively. The oxime and its acetyl derivative may be used in compositions for influencing plant growth.ALSO:A composition for influencing plant growth comprises beta-2,6-dichlorobenzaldoxime, or its acetyl derivative, and a solid or liquid inert carrier. A dust preparation for combating premature sprouting of potatoes comprises 4% of active substance, 16% of kieselguhr and 80% of magnesium marlstone. A specified liquid preparation comprises 25% of active substance dissolved in 61% of xylene and 6% of methyl ethyl ketone with the addition of 8% of an emulsifying agent. Wettable powders may be prepared using wetting agents such as fatty alcohol sulphates or alkyl-aryl sulphonates, dispersion agents such as lignin sulphonate, and carriers such as kaolin, chalk, pipe clay, magnesium marlstone, and attapulgite. For the preparation and chemical configuration of beta-2,6 - dichlorobenzaldoxime see Division C2. Specification 862,863 is referred to.ALSO:Germination of seeds is influenced, e.g. premature sprouting of potatoes is retarded, by treating them with a composition comprising, as active substance, beta-2,6-dichlorobenzaldoxime, or its acetyl derivative, and a solid or liquid inert carrier. A dusting composition may comprise between 1 and 20%, by weight, of active substance in admixture with talc, kieselguhr and/or magnesium marlstone. Specification 862,863 is referred to.
Patent ES-317605-A1 (ES)
Title: Torsionally resilient couplings
IPC: F16D3/74
Filed: 1965-09-18
Abstract: Flanges 3, 4 of a rotary coupling for marine installations, diesel locomotives and piston compressors, are connected by a flexible U or Z sectioned annular rubber member 8 having equal, or unequal, diameter securing edges 7 respectively, and which is integrally reinforced by torque-transmitting fabric thread inserts 10 extending axially, e.g. perpendicularly, between the securing edges 7, the inserts 10 being enveloped by a further layer of peripherally extending centrifugal reinforcing inserts 12, in turn enclosed by a rubber layer 14.
Patent ES-343457-A1 (ES)
Title: Method for making multiwall vessels
IPC: F17C1/04
Filed: 1967-07-27
Abstract: A pressure vessel, e.g. a compressed gas storage container comprises a plurality of metal shells of circular horizontal cross-section, e.g. spheres or domed-ended vertical cylinders located in spaced relation one within the other each shell comprising two identical halves welded together internally and externally, and the space between adjacent shells being filled with load transmitting heat insulating material, e.g. polyurethane foam. Construction of a multiwalled spherical container is effected by cutting a semicircular recess O 1 , O1 1 , Fig. 3, in the machined rim of each of two hemispherical halves C1, C1 1 of a first shell, abutting the two half-shells with their rims in a horizontal plane and with their recesses O 1 , O1 1 in register to form a manhole, welding the two half shells C1, C1 1 together from both inside and outside the shell, at S 1 , S1 1 , surrounding the welded shell by two similar but larger diameter half-shells C 2 , C1 2 , Fig. 5, spaced from said first shell and with abutting rims provided with recesses O2, O1 2 in register with the manhole of the first shell, rotating said first shell one revolution about a vertical axis X, X1, Fig. 6, whilst welding the line of abutment of the second shell from a position inside the first shell adjacent the manhole therein, welding the outside of the second shell, and bolting the two shells together with their manholes in register and finally welding coverplates. The composite container so formed has an effective wall thickness of 200 mm. which is greater than can conveniently be welded.
Patent ES-344048-A1 (ES)
Title: Benzenesulphonyl-ureas and process for their manufacture
IPC: C07D309/14
Filed: 1967-08-11
Abstract: Novel compounds of the general formula and their physiologically tolerable salts with bases, for example sodium salts, wherein X represents a chlorine or bromine atom or a methyl group linked to the 4- or 5-position with respect to the carboxylic amide group, preferably a chlorine atom, and Y represents a hydrogen atom or a methyl group are prepared by one of the following methods: (a) Reacting a benzenesulphonyl-isocyanate, -carbamic acid ester, -thiolcarbamic acid ester, -urea, -semi-carbazide or -semicarbazone carrying the substituent of formula in the p-position with an amine carrying the substituent of Formula III or a salt thereof (b) reacting a sulphonamide of the formula or a salt thereof with an isocyanate, carbamic acid ester, thiolcarbamic acid ester, carbamic acid halide or urea carrying the substituent of Formula III (c) hydrolysing a correspondingly substituted benzenesulphonyl-isourea ether, -isourea ester, -isothiourea ether, -parabanic acid or -haloformic acid amidine (d) adding water on to a correspondingly substituted carbodiimide (e) replacing the sulphur atom in a correspondingly substituted benzene-sulphonyl-thiourea by an oxygen atom (f) hydrogenating a corresponding benzenesulphonyl-urea containing, in the molecule, an unsaturated linkage and (g) introducing by acylation the radical of formula into a benzenesulphonyl-urea of the formula and, if desired, converting the resulting compound into a physiologically tolerable salt thereof by reaction with a base. N - [4 - (beta - <2 - methoxy 5 - chloro - benzamido > - ethyl) - benzenesulphonyl] - N1 - acetylurea is prepared by acylation with acetic acid anhydride of the amine. N,N1 - bis - 4 - [beta - < - 2 - methoxy - 5- chloro - benzamido > - ethyl) - benzenesulphonyl]- urea is prepared by treatment of the corresponding carbamic acid with ammonia in the presence of the corresponding sulphonamide. N - [4 - (beta - < 2 - methoxy - 5 - chloro - benzamido > - ethyl) - benzenesulphonyl] - 3 - cyclohexyl-parabanic acid is prepared by reaction of N - cyclohexyl - parabanic acid and 4 - (beta- [2 - methoxy - 5 - chloro - benzamido] - ethyl)- benzenesulphochloride. N - [4 - beta - < 2 - methoxy - 5 - chloro - benzamido > ethyl) - benzenesulphonyl] - N1 - cyclohexyl-isothiourea methyl ether is prepared by reaction of cyclohexylamine and N1[4-(beta-<2- methoxy - 5 - chloro - benzamido > ethyl) - benzenesulphonyl] - imino - dithiocarbonic acid dimethyl ester which is itself prepared by reaction of dimethyl sulphate on the potassium salt of the corresponding dithiocarbonic acid. Pharmaceutical compositions in conventional form for oral or parenteral administration useful in treating diabetes comprise an above novel compound and a suitable pharmaceutical carrier.
Patent ES-346973-A1 (ES)
Title: Improvements in or relating to disc brakes
IPC: F16D55/00
Filed: 1967-11-10
Abstract: A disc brake comprises a pad assembly 14, 16 supported within an opening 12 in an L-shaped fixed support 10, a sliding stirrup 34 guided by removable key members 44 mounted on axially extending opposed parallel edges 24 of the support 10 and a further pad assembly 28, 30 having a rigid backing plate 28 provided with ends mounted independently of the stirrup 34 in sliding engagement with the outermost free ends. 26 of the edges 24. As shown, the backing plate of the pad assembly 28, 30 has two slots 32 which co-operate with the edges 26 of the support arms 22 to prevent circumferential movement. The key members 44 are secured to the support 10 by pins 52. The key members have a resilient layer 54 of elastomeric material or of synthetic resin which may be coated or bonded to all of its faces including 48. Rattling is prevented by the resilient coating 54 and also by a magnet 64 between the back plate 28 and the stirrup 34 and by a further magnet between the other back plate 14 and the piston (38) of the brake actuator (40, Fig. 2, not shown). The friction pad assembly 14, 16 has projections 20 on the back plate 14 which are maintained against the outer walls of slots 18 in the opening 12 by a leaf spring 21. The support 10 is made of two parts 56, 58 secured together by studs 60 and bolts 62. The brake may alternatively be mechanically operated.