Patent EA-001380-B1 (EA)
Title: Phenylacetic acid derivatives
Inventor: MULLER RUTH
IPC: C07C331/12
Filed: 1996-07-12
Abstract: 1. A phenylacetic acid derivative of the formula I    where the substituents and the index have the following meanings:  X is NOCH3, CHOCH3 and CHCH3;  Y is NR and O;  R, R<1> are hydrogen and C1-C4alkyl;  R<2> is hydrogen, C1-C6alkyl, C1-C4haloalkyl and C3-C6cycloalkyl; R<3> is C2-C6alkynyl or C2-C6alkenyl, residues are optionally partially or fully halogenated and/or has attached one to three of the following radicals: cyano, nitro, hydroxy, mercapto, amino, carboxyl, aminocarbonyl, aminothiocarbonyl, halogen, C1-C6alkylaminocarbonyl, di-C1-C6alkylaminocarbonyl, C1-C6alkylaminothiocarbonyl, di-C1-C6alkylaminothiocarbonyl, C1-C6alkylsulfonyl, C1-C6alkylsulfoxyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkoxycarbonyl, C1-C6alkylthio, C1-C6alkylamino, di-C1-C6alkylamino, C2-C6alkenyloxy, C3-C6cycloalkyl, C3-C6cycloalkyloxy, heterocyclyl, heterocyclyloxy, aryl, aryloxy, aryl-C1-C4alkoxy, arylthio, aryl-C1-C4alkylthio, hetaryl, hetaryloxy, hetaryl-C1-C4alkoxy, hetarylthio, hetaryl-C1-C4alkylthio, it being possible for the cyclic radicals, in turn, to be partially or fully halogenated and/or to have attached to them one to three of the following groups: cyano, nitro, hydroxy, mercapto, amino, carboxyl, aminocarbonyl, aminothiocarbonyl, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkylsulfonyl, C1-C6alkylsulfoxyl, C3-C6cycloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkoxycarbonyl, C1-C6alkylthio, C1-C6alkylamino, di-C1-C6alkylamino, C1-C6alkylaminocarbonyl, di-C1-C6alkylaminocarbonyl, C1-C6alkylamino-thiocarbonyl, di-C1-C6alkylaminothiocarbonyl, C2-C6alkenyl, C2-C6alkenyloxy, benzyl, benzyloxy, aryl, aryloxy, arylthio, hetaryl, hetaryloxy, hetarylthio and C(=NOR<a>)-An-R<b>; R<4> is hydrogen,  C1-C10alkyl, C3-C6cycloalkyl, C2-C10alkenyl, C2-C10alkynyl, C1-C10alkylcarbonyl, C2-C10alkenylcarbonyl, C3-C10alkynylcarbonyl or C1-C10alkylsulfonyl, it being possible for these radicals to be partially or fully halogenated or to have attached to them one to three of the following groups: cyano, nitro, hydroxy, mercapto, amino, carboxyl, aminocarbonyl, aminothiocarbonyl, halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkylsulfonyl, C1-C6alkylsulfoxyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkoxycarbonyl, C1-C6alkylthio, C1-C6alkylamino, di-C1-C6alkylamino, C1-C6alkylaminocarbonyl, di-C1-C6alkylaminocarbonyl, C1-C6alkylaminothiocarbonyl, di-C1-C6alkylaminothiocarbonyl, C2-C6alkenyl, C2-C6alkenyloxy, C3-C6cycloalkyl, C3-C6cycloalkyloxy, heterocyclyl, heterocyclyloxy, benzyl, benzyloxy, aryl, aryloxy, arylthio, hetaryl, hetaryloxy and hetarylthio, it being possible for the cyclic groups, in turn, to be partially or fully halogenated or to have attached to them one to three of the following groups: cyano, nitro, hydroxy, mercapto, amino, carboxyl, aminocarbonyl, aminothiocarbonyl, halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkylsulfonyl, C1-C6alkylsulfoxyl, C3-C6cycloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkyloxycarbonyl, C1-C6alkylthio, C1-C6alkylamino, di-C1-C6alkylamino, C1-C6alkylaminocarbonyl, di-C1-C6alkylaminocarbonyl, C1-C6alkylaminothiocarbonyl, di-C1-C6alkylamino-thiocarbonyl, C2-C6alkenyl, C2-C6alkenyloxy, benzyl, benzyloxy, aryl, aryloxy, arylthio, hetaryl, hetaryloxy, hetarylthio or C(=NOR<a>)-An-R<b>; aryl, arylcarbonyl, arylsulfonyl, hetaryl, hetarylcarbonyl or hetarylsulfonyl, it being possible for these radicals to be partially or fully halogenated or to have attached to them one to three of the following groups: cyano, nitro, hydroxy, mercapto, amino, carboxyl, aminocarbonyl, aminothiocarbonyl, halogen, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkylcarbonyl, C1-C6alkylsulfonyl, C1-C6alkylsulfoxyl, C3-C6cycloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkyloxycarbonyl, C1-C6alkylthio, C1-C6alkylamino, di-C1-C6alkylamino, C1-C6alkylaminocarbonyl, di-C1-C6alkylaminocarbonyl, C1-C6alkylaminothiocarbonyl, di-C1-C6alkylaminothiocarbonyl, C2-C6alkenyl, C2-C6alkenyloxy, benzyl, benzyloxy, aryl, aryloxy, hetaryl, hetaryloxy or C(=NOR<a>)-An-R<b>; where A is oxygen, sulfur or nitrogen and the nitrogen having attached to it hydrogen or C1-C6alkyl; n is 0 or 1; R<a> is hydrogen or C1-C6alkyl and  R<b> is hydrogen or C1-C6alkyl, or salts thereof. 2. Phenylacetic acid derivatives of the formula I according to claim 1, wherein R<2> is hydrogen, C1-C6alkyl and C3-C6cycloalkyl; and R<3> is C2-C6alkynyl, C2-C6alkenyl; and other substituents have the meanings determined in claim 1. 3. Phenylacetic acid derivatives of the formula I according to claim 1, wherein X is NOCH3, Y is NH, R<1> is methyl.