Patent SG-11201808906R-A (SG)
Title: Compositions and methods of vaccination against dengue virus in children and young adults
Inventor: WALLACE DEREK
IPC: A61P31/14
Filed: 2017-04-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111101111011101010111110101111101110101111111101111101011111111101111011111 International Bureau ... .1 j ..... .....i (10) International Publication Number (43) International Publication Date WO 2017/179017 Al 19 October 2017(19.10.2017) WIPO I PCT (51) International Patent Classification: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, A61K 39/12 (2006.01) A61P 31/14 (2006.01) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (21) International Application Number: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, PCT/IB2017/052160 NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (22) International Filing Date: RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 13 April 2017 (13.04.2017) TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (25) Filing Language: English (84) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of regional protection available): ARIPO (BW, GH, (30) Priority Data: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 62/322,167 13 April 2016 (13.04.2016) US TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (71) Applicant: TAKEDA VACCINES, INC. [US/US]; One DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Takeda Parkway, Deerfield, Illinois 60015 (US). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (72) Inventor: WALLACE, Derek; Aeschrain 2b, 6318 Wal- GW, KM, ML, MR, NE, SN, TD, TG). chwil (CH). Declarations under Rule 4.17: (74) Agents: HANSON, Roberta et al.; 2200 Wells Fargo Cen- ter, 90 S. Seventh Street, Minneapolis, Minnesota 55402- — as to applicant's entitlement to apply for and be granted a 3901 (US). patent (Rule 4.1700) (81) Designated States (unless otherwise indicated, for every Published: kind of national protection available): AE, AG, AL, AM, report (Art. 21(3)) with international search AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, VIRUS IN CHILDREN AND YOUNG (54) Title: COMPOSITIONS AND METHODS OF VACCINATION AGAINST DENGUE ADULTS Deny • 2 FIG. 13B 10000 3 1 ... — — Denv - I 2 —....• ..... Deny - 3 1000 . • Deny - 4 10 i, ...... ,.. 4, Dengue- naive at o baseline 4) 1 1-1 28 Nip 1$D sot 720 Study Day IN 1-1 0 01 (57) : Embodiments herein concern compositions, methods, and uses for inducing an immune response to all four dengue IN virus serotypes in a child or young adult from about 1 year to about 20 years of age. Some embodiments concern compositions that Il ---- can include, but are not limited to, dengue virus chimeras that, either alone or in combination with other constructs, can be used in a IN vaccine composition against all four dengue virus serotypes. In certain embodiments, compositions can include constructs of more O than one serotypes of dengue virus, such as dengue- 1 (DEN-1) virus, dengue-2 (DEN- 2) virus, dengue-3 (DEN-3) virus and/or ei dengue-4 (DEN-4) virus, at various concentrations or ratios in order to improve protection from infection in children and young en. ) adults. In certain embodiments, viruses of the formulations are limited to dengue virus serotypes. Other embodiments concern meth- '° ods of administering immunogenic compositions against dengue virus that can include chimeric dengue constructs and live, attenu - .,- ated dengue viruses using single, dual or other regimens.