Patent SG-11201909302W-A (SG)
Title: Non-invasive venous waveform analysis for evaluating a subject
Inventor: BROPHY COLLEEN
IPC: A61B5/02
Filed: 2018-04-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 18 October 2018 (18.10.2018) WIPO I PCT (51) International Patent Classification: A61B 5/02 (2006.01) A61B 5/0295 (2006.01) A61B 5/024 (2006.01) A61B 5/00 (2006.01) A61B 5/029 (2006.01) (21) International Application Number: PCT/US2018/027439 (22) International Filing Date: 13 April 2018 (13.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/485,423 14 April 2017 (14.04.2017) US (71) Applicant: VANDERBILT UNIVERSITY [US/US]; 305 Kirkland Hall, 2201 West End Avenue, Nashville, TN 37240 (US). (72) Inventors: BROPHY, Colleen, M.; 305 Kirkland Hall, 2201 West End Avenue, Nashville, TN 37240 (US). HOCKING, Kyle, M.; 305 Kirkland Hall, 2201 West End Avenue, Nashville, TN 37240 (US). EAGLE, Susan, S.; 305 Kirkland Hall, 2201 West End Avenue, Nashville, TN 37240 (US). BAUDENBACHER, Franz, J.; 305 Kirkland Hall, 2201 West End Avenue, Nashville, TN 37240 (US). ALVIS, Bret, D.; 305 Kirkland Hall, 2201 West End Av- enue, Nashville, TN 37240 (US). (74) Agent: HARPER, David, S.; Mcdonnell Boehnen Hulbert & Berghoff LLP, 300 South Wacker Drive, Chicago, IL 60606 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = (54) Title: NON-INVASIVE VENOUS WAVEFORM ANALYSIS FOR EVALUATING A SUBJECT (57) : An example method includes detecting, via a sensor, vibra- tions originating from a vein of a subject and obtaining an intensity spec- 400 tram of the detected vibrations over a range of frequencies. The method /7. further includes using the obtained intensity spectrum to determine a met- ric selected from a group that includes: a pulmonary capillary wedge pres- sure (PCWP), a mean pulmonary arterial pressure, a pulmonary artery di- astolic pressure, a left ventricular end diastolic pressure, a left ventricu- lar end diastolic volume, a cardiac output, total blood volume, and a vol- ume responsiveness of the subject. An example computing device and an example non-transitory computer readable medium that are related to the method are disclosed as well. OBTAIN INTENSITY SPECTRUM OF DETECTED VIBRATIONS OVER RANGE OF FREQUENCIES omit °nolo mu onm im Imo oimIE (10) International Publication Number WO 2018/191588 Al 404 DETECT, VIA SENSOR, VIBRATIONS ORIGINATING FROM VEIN OF SUBJECT W O 20 18/ 19 15 88 Al 40S USE OBTAINED INTENSITY SPECTRUM TO DETERMINE METRIC SELECTED FROM GROUP THAT INCLUDES: PULMONARY CAPILLARY WEDGE PRESSURE, MEAN PULMONARY ARTERIAL PRESSURE PULMONARY ARTERY DIASTOLIC PRESSURE, LEFT VENTRICULAR END DIASTOLIC PRESSURE, LEFT VENTRICULAR END DIASTOLIC VOLUME, CARDIAC OUTPUT, TOTAL BLOOD VOLUME, AND VOLUME RESPONSIVENESS OF SUBJECT FIG. 4A [Continued on next page] WO 2018/191588 Al MIDEDIMOMMIDIREIDIDEMMIIIIIIIM111111101111111111111111111 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))