Patent CA-3090150-A1 (CA)
Title: Ahr modulators
Inventor: ALAM MUZAFFAR
IPC: C07D471/04
Filed: 2019-02-05
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111 111111111 111111 1111 111111111 111111111 1111 1111 1111111 11 111111 1111 111 11 11 Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2019/156987 Al 15 August 2019 (15.08.2019) VVIPO I PCT (51) International Patent Classification: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, CO7D 471/04 (2006,01) CO7D 513/04 (2006,01) 11G, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RII, TJ, CO7D 487/04 (2006,01) A 61P 35/00 (2006,01) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, CO7D 498/04 (2006,01) A 61K 31/519 (2006,01) EE, ES, FL FR, GB, GR, HR, HU, 1E, IS, IT, LT, LII, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (21) International Application Number: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, PCT/US2019/016705 KM, ML, MR, NE, SN, TD, TG), (22) International Filing Date: 05 February 2019 (05,02,2019) Published: ¨ with international search report (Art, 21(3)) (25) Filing Language: English ¨ before the expiration of the time limit for amending the (26) Publication Language: English claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (30) Priority Data: 62/626,739 06 February 2018 (06,02,2018) US 62/793,260 16 January 2019 (16,01,2019) US (71) Applicant: IDEAYA BIOSCIENCES, INC. [US/USI; 7000 Shoreline Court, Suite 350, South San Francisco, CA 94080 (US). (72) Inventors: ALAM, Muzaffar; 7000 Shoreline Court, Suite 350, South San Francisco, CA 94080 (US). BECK, Hi-lary, Plake; 7000 Shoreline Court, Suite 350, South San Francisco, CA 94080 (US). DILLON, Michael, Patrick 7000 Shoreline Court, Suite 350, South San Francisco, CA 94080 (US). GONZALEZ-LOPEZ, Marcos; 7000 Shore-line Court, Suite 350, South San Francisco, CA 94080 (US). SUTTON, James, Clifford, Jr.; 7000 Shoreline Court, Suite 350, South San Francisco, CA 64080 (US). (74) Agent: DOLAN, Gregory, F.; Mintz, Levin, Cohn, Fer-ris, Glovsky and Popeo, P.C., One Financial Center, Boston, MA 02111 (US), (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (.., (54) Title: AhR MODULATORS (57) Abstract: Provided herein are compounds, compositions and methods of using the corn-Rid R2C R2d pounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The ¨81 compounds are represented by formulae: (I) wherein the letters and symbols Xl, X2, Z, Rlb, Ric, c X2 \ z N RId, Rle, R2a, R2b, R2c and R2d have the meanings provided in the specification, 11 R2b R2a We Rlb el (r) Date Recue/Date Received 2020-07-29