baber/WOPTO huggingface dataset:
Patent EP-0931077-B1 (EP)
Inventor: RANE DINANATH F
IPC: C07D401/14
Filed: 1997-09-11
Granted: 2005-04-27
Abstract: Novel tricyclic compounds of formula (1.0) or a pharmaceutically acceptable salt or solvate thereof, wherein: one of a, b, c and d represents N or NR<9> wherein R<9> is O<->, -CH3 or -(CH2)nCO2H wherein n is 1 to 3, and the remaining a, b, c and d groups represent CR<1> or CR<2>; or each of a, b, c, and d are independently selected from CR<1> or CR<2>; each R<1> and each R<2> is independently selected from H, halo, -CF3, -OR<10>, -COR<10>, -SR<10>, -S(O)tR<11> (wherein t is 0, 1 or 2), -SCN, -N(R<10>)2, -NR<10>R<11>, -NO2, -OC(O)R<10>, -CO2R<10>, -OCO2R<11>, -CN, -NHC(O)R<10>, -NHSO2R<10>, -CONHR<10>, -CONHCH2CH2OH, -NR<10>COOR<11>, -SR<11>C(O)OR<11>, -SR<11>N(R<75>)2; y is 0 (zero) or 1; n is 0, 1, 2, 3, 4, 5 or 6; T is -CO-; -SO-; -SO2-; or -CR<30>R<31>; Z represents alkyl, aryl, aralkyl, heteroalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl, -OR<40>, -SR<40>, 1C-R<40>R<42>, (i), (ii), -NR<40>R<42>, (iii). Pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel tricyclic compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human.
Patent EP-0892070-B1 (EP)
Inventor: KLEIBER JOERG DR
IPC: C12Q1/686
Filed: 1998-07-14
Granted: 2008-06-11
Abstract: Detecting a target nucleic acid in a sample comprises: (a) contacting the sample with at least one target-specific primer in a reactor coated on the inside with at least one target-specific capture probe, where the corresponding target-probe hybrids have a lower melting temperature than the corresponding target-primer hybrids; (b) performing an amplification reaction under conditions such that the target-primer hybrids are stable while the target-probe hybrids are unstable; and (c) detecting binding of the amplification products to the capture probes. Also claimed is a method for detecting a target nucleic acid in a sample comprising contacting the sample with at least one target-specific primer in a closed reactor coated on at least one optically transparent internal surface with at least one target-specific capture probe, performing an amplification reaction whereby fluorescent labels are incorporated into the amplification products and detecting binding of the amplification products to the capture probes by means of evanescence-induced fluorescence Äsee EP 245206Ü.
Patent EP-0959307-B1 (EP)
Inventor: BACHOFEN FRIEDRICH
IPC: F24F3/147
Filed: 1998-05-20
Granted: 2003-05-02
Abstract: An air conditioning system has plate type heat exchangers to exchange heat between the incoming air flow and the expelled air flow to conserve energy. The incoming air is dehumidified using hydroscopic liquid sprayed over the plate heat exchangers. Liquid which drains off the heat exchangers is collected and recycled, ie. the water is removed by heating. The liquid is cooled and recycled to the heat exchangers.
Patent EP-0895537-B1 (EP)
Inventor: ACHTMAN MARK
IPC: C12N9/52
Filed: 1998-01-20
Granted: 2004-12-01
Abstract: The present invention is concerned with a fragment of IgA1-protease having 40 to 200 amino acid residues and comprising at least 40 amino acids of an amino acid sequence as shown in SEQ ID NO:1, beginning with the amino acid in any one of positions 1 to 5 and ending with an amino acid in any one of positions 40 to 104 or a homologous sequence, its use as a carrier for a conjugate, particularly in combination with a polysaccharide, and a process for producing the peptide as well as vaccines comprising said peptide.
Patent EP-0958563-B1 (EP)
Inventor: BRANDENBUSCH MICHAEL
IPC: G08G1/0967
Filed: 1998-01-28
Granted: 2003-05-28
Abstract: Optimisation of the signalling behaviour of a detector for a system for determining the traffic situation, and thus optimisation of the energy used by said detector and of the telecommunication resources expended relative to the transmission of traffic data, is made possible by a method for determining the traffic situation which uses a control centre and stationary detectors located in several points within a road network. The detectors each gather traffic data at their respective locations and transmit traffic data to the control centre according to a predefinable signalling behaviour state. Several signalling behaviour states are provided for for each detector, which states are selected at least in accordance with traffic data and define the signalling behaviour of the detector.
Patent EP-0972410-B1 (EP)
Inventor: BANIEWICZ PAUL T
IPC: H04L12/24
Filed: 1998-03-11
Granted: 2006-10-04
Abstract: A network wherein a plurality of links connects a plurality of nodes such as cross-connects in a communication circuit network with paths interconnecting the nodes, and with there being spare capacity between a sufficient number of nodes to accommodate at least some rerouting of traffic immediately upon detection of a break in a traffic span in the network so as to restore circuit continuity within a predetermined maximum time using an improved failure detection, isolation, and recovery scheme.
Patent EP-0996447-B1 (EP)
Inventor: PODOLSKI JOSEPH S
IPC: A61K31/417
Filed: 1998-05-19
Granted: 2006-07-19
Abstract: The invention is directed to compositions and methods for modulating the human sexual response. The compositions comprise two or more pharmaceutically active agents which preferably include an alpha-adrenergic antagonist and a phosphodiesterase inhibitor.
Patent EP-1090494-B1 (EP)
Inventor: RITTER RUDOLF
IPC: H04Q7/22
Filed: 1998-06-23
Granted: 2002-06-19
Abstract: The invention relates to a method for offering, ordering and selling goods and services according to which at least one provider (1) offers said products to a plurality of participants (7) in a mobile telephone network (20) via different communication channels (61, 62, 63). Interested participants (7) enter an offer identification into their mobile telephones and through short messages transmit (10) said identification to a service centre (11) via the mobile telephone network (20). The service centre (11) recognizes a participant (7) and links data contained in the short message with participant identification data. In the case of at least some of the products offered the available quantity thereof is memorized (101) and a token is generated (204) for a deliverable order which has been received. The token is transmitted (14, 15) to the supplier (1) concerned and to the mobile telephone of the relevant participant (7). For each received order for which a token was generated the quantity indicated is decreased (208) and a product ceases (16) to be offered when the quantity indicated is zero (209) or the product has passed its expiry date.
Patent EP-1009037-B1 (EP)
Inventor: KONDO MASATAKA
IPC: H01L31/04
Filed: 1998-07-17
Granted: 2006-03-15
Abstract: Ce module de cellulaire comprend une cellule solaire (1), un élément de support (21) soutenant la cellule solaire (1) et présentant une partie métallique, ainsi qu'un élément d'espacement (31) placé entre la cellule solaire (1) et la partie métallique de l'élément de support (21). L'élément d'espacement (31) possède une conductivité thermique égale ou inférieure à 10?-3 W/cm .¿ °C et fonctionne comme matériau thermiquement isolant et/ou il possède une résistivité égale ou supérieure à 10?12 Φ .¿ cm et fonctionne comme matériau isolant, et il conserve sa forme pendant le fonctionnement de la cellule solaire (1).
Patent EP-0999967-B1 (EP)
Inventor: VAN LOON LAURENTIUS PETRUS JOS
IPC: B62B5/04
Filed: 1998-07-29
Granted: 2001-05-23
Abstract: The present invention relates to an underframe (2), in particular for trolleys, having a baseplate (4) and four castors (5, 6, 7, 8) mounted on said baseplate. Two pedals (12, 13) are fitted along the transverse side (11) of the underframe, each pedal being connected to a control strip (19, 20) situated above the castors and running along the longitudinal side. A brake of at least one castor is connected to each control strip. The control strips are interconnected by means of a swivel arm (25). The control strips run through underneath the fixing plates of the castors and comprise a cam (33) which can act upon a spring pawl (31) of the brake system of the castors. Such a design produces a very sturdy and lightweight brake system which has the minimum of parts and is very reliable in operation.
Patent EP-0991877-B1 (EP)
Title: Device, specially a pump
Inventor: KAUFMANN RALF
IPC: A61M60/818
Filed: 1998-06-15
Granted: 2002-01-23
Abstract: The inventive device consists of a disk which can be rotated around a central axis, a wobble pin which is mounted in the disk so that can rotate around an axis which is arranged at an angle in relation to the plane, of said disk, a swivel pin which is secured to the wobble pin at an angle in relation to the axis thereof, and a fastening device which prevents the swivel pin from rotating around the axis of the disk. This mechanism forms a gear enabling a rotational unidirectional movement to be translated into a back-and-forth movement in applications where limited height is available. The preferred area of application is in implantable blood pumps.
Patent EP-1019317-B1 (EP)
Inventor: VAN KEULEN ARJAN NICOLAAS JOHA
IPC: H01M8/06
Filed: 1998-09-24
Granted: 2003-07-23
Abstract: A process for purifying a gas stream containing hydrogen and carbon monoxide consisting of one or more catalysed reactions for the selective removal of carbon monoxide from the gas stream wherein a controlled amount of liquid water is introduced into the gas stream prior to some of the catalysed reactions so as to lower the temperature of the gas stream to a predetermined value at which preferential removal of carbon monoxide takes place in the associated catalysed reaction. The catalysed reactions may be selective oxidation, selective methanation or combination thereof. The process of the invention may be operated in combination with a water-gas shift reaction for the reduction of carbon monoxide in the hydrogen-containing gas stream.
Patent EP-1015286-B1 (EP)
Inventor: STAM JOSEPH S
IPC: G01N21/47
Filed: 1998-09-10
Granted: 2003-08-13
Abstract: A vehicle windshield moisture detecting system comprising: an image array sensor (32) having an array of pixle sensors wherein said pixel sensors define an imaging surface and said image sensor is adapted to be mounted in a vehicle such that said imaging surface is inclined with respect to one of the items in a group comprising: vertical and an imaging plane of a lens (33). <IMAGE>
Patent EP-1012373-B1 (EP)
Inventor: BURMEISTER GUIDO
IPC: D06N1/00
Filed: 1998-08-18
Granted: 2003-11-05
Abstract: Electrically conductive linoleum-based floor covering with a content of an additive enhancing the conductive and antistatic properties of the floor covering, whereby the floor covering comprises as an additive at least one cationic compound with a quatemary nitrogen atom, particularly a derivative of imidazole, imidazoline or morpholine, whereby the covering also contains silica, particularly kieselguhr, in addition to the common processing aids and additives.
Patent EP-1025220-B1 (EP)
Inventor: LA THANGUE NICHOLAS BARRIE
IPC: C12N1/15
Filed: 1998-10-21
Granted: 2007-01-03
Abstract: The invention provides an isolated nucleic acid (SEQ ID NO:1) encoding a novel protein, JMY, which is found to be a co-activator of p300/CBP. The invention also provides JMY polypeptides and antibodies thereto, as well as assays for modulators of the cell cycle which target the interaction of JMY with transcription factors such as E2F, ER or TBP.
Patent EP-0964737-B1 (EP)
Inventor: JITARIOUK NICOLAI
IPC: B01J19/24
Filed: 1998-10-28
Granted: 2004-07-28
Abstract: The invention relates to a hollow membrane ( 11 ) comprising two support layers arranged one above the other forming a space between them and a plurality of capillary tubes arranged between the support layers forming capillary channels for the flow of a first fluid, the space between the capillary tubes forming an internal cavity for the circulation of a second fluid around the capillary tubes, and the whole assembly being made of an organic polymer. These membranes ( 11 ) can be assembled into modules for the treatment of a fluid with intermediate porous panels ( 13 ).
Patent EP-1042513-B1 (EP)
Inventor: HEIKKILAE HEIKKI
IPC: C13B20/14
Filed: 1998-12-22
Granted: 2002-07-17
Abstract: The present invention relates to a method of producing xylose by chromatographic separation of the xylose from a sulphite cooking liquor containing for example xylose and xylonic acid. The xylose yield of the separation is affected by the xylonic acid and xylose content in the cooking liquor used in the separation and the amount of base cation used in the sulphite cooking.
Patent EP-1035841-B1 (EP)
Inventor: KOTHRADE STEPHAN
IPC: A23K20/10
Filed: 1998-11-30
Granted: 2002-07-24
Abstract: Solid dosage forms are obtained by mixing at least one polymeric binder, at least one active ingredient, and, where appropriate, conventional additives to form a plastic mixture, and shaping, using as polymeric binder a copolymer of an N-vinyllactam and a copolymerizable monomer having a hydrophobic radical. Dosage forms which show slow release of the active ingredient are obtained in a simple and low-cost manner.
Patent EP-0988812-B1 (EP)
Inventor: JOULIA GERARD
IPC: A45D34/04
Filed: 1999-09-06
Granted: 2002-01-30
Abstract: The cosmetic applicator comprises an application comb part (12). A support (2) is connected to the comb which receives a dose (7) of a product (P) with a liquid to paste consistency. The dose feed comprises a first wall (9) which deforms in response to a pressure exerted on the wall through a window (16) in the support. The support contains opening points (17) which in response to the pressure, pierce a second wall (10) of the dose.
Patent EP-1071344-B1 (EP)
Inventor: TRINKIES WOLFGANG
IPC: A24C5/42
Filed: 1999-03-17
Granted: 2002-05-15
Abstract: The arrangement has a cigarette conveyor (30), a tobacco strand shaper (20), a tobacco strand conveyer, a casing alignment device, electric motors for the driven parts, and preferably an electronic process controller which monitors the operating state of the equipment with the aid of sensors, regulates it and displays it. Independent claims are also included for a cigarette conveyor, tobacco strand shaper, tobacco strand conveyer and casing alignment device.
Patent EP-1069122-B1 (EP)
Inventor: HONMA TSUNETOSHI
IPC: C07D333/68
Filed: 1999-03-30
Granted: 2005-06-29
Abstract: Benzothiophenecarboxylic acid derivatives of the formula (I) which are useful as starting materials for producing drugs, and a process for preparing 5-hydroxybenzo[b]thiophene-3-carboxylic acid derivatives of the formula (VI) which are specific PGD<sub>2</sub> antagonists.
Patent EP-1036016-B1 (EP)
Inventor: ECKERT ERWIN
IPC: B65D77/16
Filed: 1999-03-06
Granted: 2001-11-07
Abstract: The invention relates to packaging (10) for light insulating material panels (12) used for construction purposes, especially for expandable polystyrene insulating material panels. Said packaging is provided with a film sheathing (14) having a middle section (16) and two opposing end sections (18, 20) which comprise free ends (22, 24) and which are located on the front faces. Said end sections are provided for enclosing a plurality of adjacent light insulating material panels (12) having front faces. The end sections (18, 20) of the film sheathing (14), said sections being located on the front faces, extend above the front faces of the light insulating material panels (12). The end sections (18, 20) of the film sheathing (14), said sections being located on the front faces, are each held together by means of a holding device (26). Said holding devices (26) are arranged between the middle section (16) and the free ends (22, 24) within said end sections (18, 20) of the film sheathing (14) in order to grasp the area (30, 32) to be held together of the end sections (18, 20) of the film sheathing (14).
Patent EP-1051421-B1 (EP)
Inventor: WIESSLER MANFRED
IPC: A61K41/00
Filed: 1999-01-27
Granted: 2002-12-11
Abstract: The invention relates to a compound which contains boron and which comprises the following general formula (1)in whichCb represents carborane,R2 and R3, independent of one another, represent a hydrogen atom or an organic radical, andR and R1, independent of one another, represent a hydrogen atom or an organic group, or R and R1 form a carbonyl group with the carbon atom to which they are bound.The invention also relates to a method of producing a compound containing boron and to the application of the same.
Patent EP-1060345-B1 (EP)
Inventor: RAMSTETTER ASBJOERN
IPC: B01D53/86
Filed: 1999-02-26
Granted: 2002-08-28
Abstract: L'invention concerne une installation de turbine à gaz et à vapeur (2) à combustible fossile, pour laquelle, afin d'effectuer une purification catalytique du milieu de travail (AM') détendu de la turbine à gaz (4), il est possible de prévoir un système de dosage (68) pour introduire un agent de réduction (R) dans le milieu de travail (AM') détendu. Une installation de ce type équipée d'une turbine à gaz (49) fonctionnant aussi bien au gaz qu'au mazout comme combustible (B), doit présenter un rendement particulièrement élevé du générateur de vapeur de chaleur perdue (30) de l'installation de turbine à gaz (2b), avec le moins de complexité technique, dans tous les états de fonctionnement de l'installation de turbine à gaz (2a). A cet effet, le système de dosage (68) présente un nombre de compresseurs d'air (84, 86) dont le débit peut être ajusté en fonction du type de combustible (B) acheminé jusqu'à la turbine à gaz (4).
Patent EP-1077775-B1 (EP)
Title: Appareil de distribution ameliore
Inventor: BOLTON TERENCE WILLIAM
IPC: B43K8/00
Filed: 1999-05-12
Granted: 2003-08-13
Abstract: Appareil servant à distribuer un liquide et comprenant un boîtier tubulaire dont l'une des extrémités présente un embout buccal et une coiffe allongée et l'autre des extrémités comporte un ajutage pourvu d'un orifice communiquant avec une chambre de dilatation limitée par des côtés divergents par rapport à cet orifice. Une source de liquide comprenant un corps allongé et une pointe absorbante (par exemple, un stylo à pointe de feutre) est située à l'intérieur du boîtier, les surfaces latérales du corps du stylo étant éloignées des surfaces de la paroi intérieure du boîtier, de façon à définir un passage d'air entre lesdites surfaces. Une première et une deuxième butées sont placées à l'intérieur du boîtier, une surface du corps allongée pouvant venir pousser la première de ces butées afin de positionner la pointe de la source de liquide à l'intérieur de l'orifice de l'ajutage ou à proximité étroite de cet orifice, et une extrémité dirigée vers l'arrière du corps allongé pouvant venir pousser la deuxième de ces butées afin d'introduire la pointe de la source de liquide de façon relativement étanche à l'air dans une extrémité de la coiffe allongée. L'autre extrémité de cette coiffe allongée est fermée. Ceci permet de positionner de façon sélective la source de liquide, sa pointe étant placée à l'intérieur de l'ajutage du boîtier ou à proximité étroite de cet ajutage ou étant enfermée de façon étanche à l'intérieur de la coiffe allongée quand l'appareil n'est pas en service.
Patent EP-1083898-B1 (EP)
Inventor: ANDRE PATRICE
IPC: A61P35/00
Filed: 1999-06-11
Granted: 2006-01-04
Abstract: Use of ritonavir, saquinavir or their salts as proteasome modifying drugs is new. Use of at least one human immunodeficiency virus (HIV) protease inhibitor (I) selected from ritonavir, saquinavir and their salts, in combination with a pharmaceutical carrier, is claimed for the preparation of a medicament for modulating the proteasome. An independent claim is included for a method for screening for HIV protease inhibitors, involving testing the compounds for their ability to modulate proteasome activity. ACTIVITY : Antiinflammatory; immunoregulatory; antirheumatic; antiarthritic; antidiabetic; antipsoriatic; antiviral; cytostatic. Oral treatment with saquinavir at 4 mg per day for 7 days inhibited mouse paw edema, induced by injection of lymphocytic chorio-meningitis virus, by 73%. MECHANISM OF ACTION : HIV protease inhibitor; proteasome modulator. Proteasome is the central enzymatic protein degradation system, present in cytosol and cell nuclei and having multiple peptidase activity. (I) especially inhibit the chymotrypsin-like activity and increase the trypsin-like activity of proteasome; modify the presentation of antigens at the cell surface (in combination with the major histocompatibility complex class 1); and inhibit or modify the activation of cytotoxic CD8+> T lymphocytes.
Patent EP-1102770-B1 (EP)
Inventor: PLATZEK JOHANNES
IPC: C07D487/22
Filed: 1999-07-15
Granted: 2003-08-20
Abstract: The invention relates to paramagnetic 3-,8-substituted deuteroporphyrin derivatives having different substituents in positions 13 and 17 of the porphyrin skeleton, diagnostic substances containing said compounds, their use in magnetic resonance imaging of necrosis and infarction and methods for producing said compounds and substances.
Patent EP-1114449-B1 (EP)
Inventor: VAARTSTRA BRIAN A
IPC: H01L21/8246
Filed: 1999-08-10
Granted: 2009-03-25
Abstract: A method for use in the fabrication of integrated circuits includes providing a substrate assembly having a surface. A diffusion barrier layer is formed over at least a portion of the surface. The diffusion barrier layer is formed of RuSix, where x is in the range of about 0.01 to about 10. The barrier layer may be formed by depositing RuSix by chemical vapor deposition or the barrier layer may be formed by forming a layer of ruthenium relative to a silicon containing region and performing an anneal to form RuSix from the layer of ruthenium and the silicon containing region. Capacitor electrodes, interconnects or other structures may be formed with such a diffusion barrier layer.
Patent EP-1115384-B1 (EP)
Inventor: PETTERSSON ANDERS
IPC: A61K47/32
Filed: 1999-09-24
Granted: 2003-08-27
Abstract: A pharmaceutical composition for the treatment of acute pain by sublingual administration is described. The composition comprises an essentially water-free, ordered mixture of fentanyl or a pharmaceutically acceptable salt thereof in the form of microparticles which are adhered to the surface of carrier particles which are substantially larger than the particles of fentanyl, and are essentially water-soluble. In a preferred embodiment, the composition also contains a bioadhesion and/or mucoadhesion promoting agent. The invention also relates to the preparation of the composition, and to the use of the composition for the treatment of acute pain.
Patent EP-1123164-B1 (EP)
Inventor: BEHR RAINER
IPC: B05C1/06
Filed: 1999-10-21
Granted: 2003-04-09
Abstract: The device contains two or more spindles (7, 7') whose axes run parallel to the surface (2a) of the work piece (2) being coated. Brushes (8) at the end of the spindles are used to evenly distribute the applied coating. At least one of the spindles (7) can be moved along the surface being coated by rotating it.
Patent EP-1145020-B1 (EP)
Inventor: WILLSCH MICHAEL
IPC: G01R15/24
Filed: 1999-12-13
Granted: 2003-03-12
Abstract: The method and system serve to optically detecting an electric current with an extended measurement range. To that end, two light signals having different wavelengths pass through a Faraday element, the polarization of the two light signals being rotated in each case by at least 0.0014°/A as a function of the electric current. By taking account of both wavelength-dependent polarization rotations, at least one of which lies beyond an unambiguity range, the measurement range is extended distinctly beyond the unambiguity range of each of the two light signals.