Patent SG-11201808196U-A (SG)
Title: Neoantigens and methods of their use
Inventor: ROONEY MICHAEL STEVEN
IPC: C07K4/12
Filed: 2017-03-31
Abstract: International Publication Date (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111101111011101010111110101111101110101111110110010111011111101111011111 International Bureau .. .... ..Yejd ..... ...„1 (10) International Publication Number WO 2017/173321 Al 5 October 2017 (05.10.2017) IN I PO I P CT (51) (21) (22) (25) (26) (30) (71) (72) (74) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 38/17 (2006.01) CO7K 16/30 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 39/00 (2006.01) CO7K 4/12 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, C07K 14/47 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, PCT/US2017/025462 KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, International Filing Date: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 31 March 2017 (31.03.2017) NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, Filing Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, Publication Language: English ZA, ZM, ZW. Priority Data: (84) Designated States (unless otherwise indicated, for every 62/316,530 31 March 2016 (31.03.2016) US kind of regional protection available): ARIPO (BW, GH, 62/316,533 31 March 2016 (31.03.2016) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 62/316,547 31 March 2016 (31.03.2016) US TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 62/316,552 31 March 2016 (31.03.2016) US TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 62/316,567 1 April 2016 (01.04.2016) US DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 62/316,571 1 April 2016 (01.04.2016) US LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Applicant: NEON THERAPEUTICS, INC. [US/US]; 40 GW, KM, ML, MR, NE, SN, TD, TG). Erie Street, Suite 110, Cambridge, Massachusetts 02139 (US). Published: Inventor: ROONEY, Michael Steven; 33 Mather Street, with international search report (Art. 21(3)) Boston, Massachusetts 02124 (US). — before the expiration of the time limit for amending the Agents: MCANDREW, Christopher W. et al.; Wilson claims and to be republished in the event of receipt of Sonsini Goodrich & Rosati, 650 Page Mill Road, Palo amendments (Rule 48.2(h)) Alto, California 94304 (US). — — = = = = Title: NEOANTIGENS AND METHODS OF THEIR USE 10' 101 10 10° : The field of the present invention in the immunotherapy of cancer. (54) Il .. example, peptide binding agents, and their use, for = = = , ' - i• io• . • • • • - . .. • . . . • • ' ..• • : 0 % .:. 4 • . • _ = = — = = _ ' .1 .. . • t-1; . •. • :: I's ' 1 ' . • • .../:.;:: : 7. • • : . .. .. 1 . . . '.,%. • • 0. • . • • , . • .. = — - • 4 1-1 ei en Cr) IN 11 IN Il (57) ei 10' 10\" 10' 10' 10 Predicted Affinity (nM) FIG. 1 relates to immunotherapeutic peptides, 0