Patent SG-11201408168U-A (SG)
Title: Azetidine and piperidine compounds useful as pde10 inhibitors
Inventor: ALLEN JENNIFER R
IPC: A61K31/497
Filed: 2013-06-14
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau „ (10) International Publication Number (43) International Publication Date ^ ^ WO 2013/188724 A1 19 December 2013 (19.12.2013) WIPO I PCT (51) International Patent Classification: C07D 401/14 (2006.01) A61K 31/497 (2006.01) C07D 403/14 (2006.01) A61P 25/00 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 61/659,911 14 June 2012 (14.06.2012) (74) Agent: LEMOINE, Elsa D.; Amgen Inc., Patent Opera­ tions /MS 28-2-C, One Amgen Center Drive, Thousand Oaks, California 91320-1799 (US). PCT/US2013/045768 14 June 2013 (14.06.2013) English (71) Applicant: AMGEN INC. [US/US]; One Amgen Center Drive, Thousand Oaks, California 91320-1799 (US). (72) Inventors: ALLEN, Jennifer R.; 139 Via Aldea, Newbury Park, California 91320 (US). CHEN, Jian J.; 5448 Castillo de Rosa, Camarillo, California 93012 (US). FROHN, Michael J.; 2808 Cedar Wood Place, Thousand Oaks, California 91362 (US). KALLER, Matthew Richard; 1644 Red Rock Avenue, Ventura, California 93004 (US). LIU, Qingyian; 4631 Paseo Girasol, Ca­ marillo, California 93012 (US). NGUYEN, Thomas T.; 468 Calle Veracruz, Newbury Park, California 91320 (US). PICKRELL, Alexander J.; 30948 Minute Man Way, Westlake Village, California 91361 (US). QIAN, Weny- uan; 3872 Fountain Street, Camarillo, California 93012 (US). RZASA, Robert M.; 160 Kennedy Avenue, Ven­ tura, California 93003 (US). ZHONG, Wenge; 2921 Venezia Lane, Thousand Oaks, California 91362 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, English MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, us SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) Published: — with international search report (Art. 21(3)) (54) Title: AZETIDINE AND PIPERIDINE COMPOUNDS USEFUL AS PDE10 INHIBITORS CJ l> 00 00 X (I) i-H (57) Abstract: Azetidine and piperidine compounds of formula (I) as defined in the specification, compositions containing them, O and processes for preparing such compounds and intermediates thereof. Provided herein also are methods of treating cognitive dis - CJ orders or diseases treatable by inhibition of PDE10, such as Huntington's Disease, schizophrenia, bipolar disorder, obsessive-com- Q pulsive disorder, and the like.