Patent SG-11201407265R-A (SG)
Title: Novel ha binding agents
Inventor: SHRIVER ZACHARY
IPC: A61P31/16
Filed: 2013-05-10
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 14 November 2013 (14.11.2013) WIPOIPCT (10) International Publication Number WO 2013/170139 A1 (51) International Patent Classification: A61K39/42 (2006.01) A61P 31/16 (2006.01) C07K16/10 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 61/645,554 61/716,447 13/830,367 PCT/US2013/040534 10 May 2013 (10.05.2013) English English US US us 10 May 2012 (10.05.2012) 19 October 2012 (19.10.2012) 14 March 2013 (14.03.2013) (71) Applicant: VISTERRA, INC. [US/US]; One Kendall Square, Suite B3301, Building 300, 3rd Floor, Cambridge, MA 02139 (US). (72) Inventors: SHRIVER, Zachary; 16 Fairmont Avenue, Cambridge, MA 02139 (US). VISWANATHAN, Karthik; 3114 Stearns Hill Road, Waltham, MA 02451 (US). SUB- RAMANIAN, Vidya; 158 Summer Street, Apt 414, Somerville, MA 02143 (US). RAGURAM, Sasisekharan; 2 Barsky Ct, Princeton, NJ 08540 (US). (74) Agent: LU, Shihua; Lando & Anastasi LLP, Riverfront Office Park, One Main Street; Suite 1100, Cambridge, MA 02142 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (54) Title: NOVEL HA BINDING AGENTS Heavy Chain FIG. 1 EVQLLESGGGLVKPGQSLKLSCAASGFTFTSYGMHWVRQPPGKGLEWVAVISYDGSYKYYADSVQG RFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDSRLRSLLYFEWLSQGYFNPWGAGTTLTVSSASr KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPSPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSW TVPSSSLGTQTYICNVNHKPSNTKVDKKVSPPKSCDKTHTCPPCPGTELLGGPSVFLFPPKPKDTL MISRTPEVTCin?VDVSHEDPEVKFNWYVDG¥BVHNAKTKPREEQXNSTYRWSVLTVLHQDWLNGK EYKCKVSHKALPAPX&XTX8KAKG8PREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWES NGQPENMyKTrpPVLDSDGSFFLYSKLTVDKSBMQQGNVFSCSVMHEALBNHYTQKSLSLSPGK (SEO ID NO: 94) ^ Light Chain o\ EfviVH {XS^^SLAVSL(:s!tRAl iA^ VKNYLAW7OGJ-QAPKLU : : V : WAS s VPDR^S^S^S^a i 5 arTmSIMAEINAVWCQOWmPPTPGGISmDttiGSVAAPSVFlFPPSIXaitCSGTASVVaiNNfYPftSAK ® VQWKVDPiAlQSSNSQESVTliGOSKQSTYSlSSTlTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGSC (SEQ ID NO: 9 5) rn i-H (57) Abstract: This disclosure relates to novel peptide agents, e.g., antibodies and antigenbinding fragments thereof, that bind hem- © agglutinin protein of influenza viruses, and methods of their use.