Patent SG-11201903456W-A (SG)
Title: Piperidine derivatives as inhibitors of ubiquitin specific protease 7
Inventor: O'DOWD COLIN
IPC: C07D513/04
Filed: 2017-10-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 April 2018 (26.04.2018) WIPO I PCT omit IIl °nolo olomll oimIE (10) International Publication Number WO 2018/073602 Al (51) International Patent Classification: C07D 401/04 (2006.01) C07D 473/00 (2006.01) C07D 401/06 (2006.01) C07D 487/04 (2006.01) CO7D 401/14 (2006.01) CO7D 491/04 (2006.01) CO7D 403/04 (2006.01) CO7D 513/04 (2006.01) CO7D 471/04 (2006.01) A61K 31/506 (2006.01) CO7D 471/10 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/GB2017/053175 (22) International Filing Date: 20 October 2017 (20.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1617758.6 20 October 2016 (20.10.2016) GB (71) Applicant: ALMAC DISCOVERY LIMITED [GB/GB]; Almac House, 20 Seagoe Industrial Estate, Craigavon BT63 5QD (GB). (72) Inventors: O'DOWD, Colin; c/o Almac Discovery Limit- ed, Almac House, 20 Seagoe Industrial Estate, Craigavon Armagh BT63 5QD (GB). HARRISON, Tim; c/o Almac Discovery Limited, Almac House, 20 Seagoe Industrial Es- tate, Craigavon Armagh BT63 5QD (GB). HEWITT, Pe- ter; c/o Almac Discovery Limited, Almac House, 20 Sea- goe Industrial Estate, Craigavon Armagh BT63 5QD (GB). ROUNTREE, Shane; c/o Almac Discovery Limited, Al- mac House, 20 Seagoe Industrial Estate, Craigavon Ar- magh BT63 5QD (GB). HUGUES, Miel; c/o Almac Dis- covery Limited, Almac House, 20 Seagoe Industrial Estate, Craigavon Armagh BT63 5QD (GB). BURKAMP, Frank; c/o Almac Discovery Limited, Almac House, 20 Seagoe In- dustrial Estate, Craigavon Armagh BT63 5QD (GB). JOR- DAN, Linda; c/o Almac Discovery Limited, Almac House, 20 Seagoe Industrial Estate, Craigavon Armagh BT63 5QD (GB). HELM, Matthew; c/o Almac Discovery Limited, Almac House, 20 Seagoe Industrial Estate, Craigavon Ar- magh BT63 5QD (GB). BROCCATELLI, Fabio; c/o Al- mac Discovery Limited, Almac House, 20 Seagoe Indus- trial Estate, Craigavon Armagh BT63 5QD (GB). CRAW- FORD, James John; c/o Almac Discovery Limited, Al- mac House, 20 Seagoe Industrial Estate, Craigavon Armagh BT63 5QD (GB). GAZZARD, Lewis; c/o Almac Discov- ery Limited, Almac House, 20 Seagoe Industrial Estate, Craigavon Armagh BT63 5QD (GB). WERTZ, Ingrid; c/ o Almac Discovery Limited, Almac House, 20 Seagoe In- dustrial Estate, Craigavon Armagh BT63 5QD (GB). LEE, O Wendy; c/o Almac Discovery Limited, Almac House, 20 N O Seagoe Industrial Estate, Craigavon Armagh BT63 5QD (GB). (74) Agent: BOULT WADE TENNANT; Verulam Gardens, 70 Gray's Inn Road, London Greater London WC1X 8BT (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) O (57) : The present invention concerns the identification of inhibitors of ubiquitin specific protease 7 (USP7), and methods 0 of use thereof. (54) Title: PIPERIDINE DERIVATIVES AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7