baber/WOPTO huggingface dataset:
Patent DE-69130171-T2 (DE)
Inventor: TSIEN ROGER
IPC: C12N9/00
Filed: 1991-07-01
Granted: 1999-06-24
Abstract: The invention provides labeled proteins suitable for determining the presence of cAMP, other second messengers and organic molecules. The proteins are separately labeled with fluorochromes which, when in close spatial proximity, preferably, less than about 6 nm, interact through the transfer of energy from one fluorochrome to the other. A composition of matter, (S1.A)n1(S2.D)n2 is provided wherein S1 and S2 are two proteins which are associated in one state and substantially disassociated in another, the equilibrium between which is controlled by the free concentration of an analyte, and A and D are fluorochromes, the emission wavelength of fluorochrome D overlapping the excitation wavelength of fluorochrome A and the distance between A and D being in sufficiently close proximity to allow the radiationless transfer of energy between the fluorochromes. A and D can be selected from a variety of acceptor, donor pairs such as fluorescein and tetramethylrhodamine and derivatives thereof. The concentration of analytes such as cAMP in a sample can be determined by contacting the sample with (S1.A)n1(S2.D)n2 providing energy near the excitation wavelength of D and measuring the fluorescence of A or D, the concentration of cAMP and other said analytes being determined by the ratio of emission of D to the emission of A, previously calibrated with reference solutions of known analyte concentration.
Patent DE-69133474-T2 (DE)
Inventor: BERGMAN JERALD W
IPC: A01H5/10
Filed: 1991-02-08
Granted: 2006-05-24
Abstract: The present invention relates to a safflower seed, a safflower plant, a safflower oil, a safflower seed product, a safflower variety and a method for producing a safflower seed. More specifically, the invention relates to a safflower seed having either (a) an oleic acid content of about 80% or greater or (b) a linoleic acid content of about 80% or greater, relative to the total fatty acid content of the seed when the seed is produced at a mean temperature of about 70 DEG F. The oil is derived from said seed and the safflower plant produces said seed.
Patent DE-69200284-T2 (DE)
Inventor: HEAULME MICHEL
IPC: A61P25/28
Filed: 1992-02-05
Granted: 1995-03-02
Abstract: The invention concerns the use of a compound of formula (I)  (* CHEMICAL STRUCTURE *) (I) wherein R and R1, each independently, represent a hydrogen atom or a methyl group, and its pharmaceutically acceptable acid addition salts, as free radical scavengers. The pharmaceutical compositions containing these compounds may be employed in the treatment and/or prevention of pathological processes involving cell damage due to the formation of free radicals. The invention also concerns the compounds of formula (I) wherein at least one of R and R1 is methyl, which are new compounds, as well as the process for the preparation thereof and the pharmaceutical compositions containing them.
Patent DE-69201175-T2 (DE)
Inventor: JACQUOT ROLAND
IPC: C07C37/00
Filed: 1992-08-24
Granted: 1995-05-18
Abstract: The invention relates to a process making it possible to selectively monodebrominate 1,6-dibromo-2-hydroxynaphthalene in position 1. 
<??>According to this process, a reaction is carried out, in an acidic organic solvent and in the presence of a catalyst based on tungsten carbide, between (i) the said dibrominated naphthalene and (ii) molecular hydrogen or a compound capable of generating nascent hydrogen in the reaction medium. 
<??>Mainly 6-bromo-2-hydroxynaphthalene is thus collected.
Patent DE-69204890-T2 (DE)
Inventor: PONS FERNAND
IPC: B23K103/04
Filed: 1992-03-31
Granted: 1996-04-25
Abstract: The present invention relates to a method for joining a manganese steel workpiece to another, carbon steel workpiece, as well as to an assembly obtained by this process. 
<??>This method essentially consists in depositing an austeno-ferritic stainless steel (1) at the end of a carbon steel workpiece (2) and in welding the latter, provided with the deposition (1) at its end, to a manganese steel workpiece (3). 
<??>This method applies especially to joining a rail to a track workpiece forming a frog. 
<IMAGE>
Patent DE-69206259-T2 (DE)
Inventor: DIRKSING ROBERT
IPC: A46B5/00
Filed: 1992-01-30
Granted: 1996-07-18
Abstract: A toothbrush employing a non-pinching resilient twin beam structure to connect the brush handle to the brush head, the twin beam structure having one beam which is wider in cross-sectional width than the other beam in order to prevent soft oral tissue from entering the opening formed between the beams and being pinched between by the interior surfaces of the beams during deformation of the twin beam structure.
Patent DE-69210986-T2 (DE)
Inventor: BJOERKMAN AKE
IPC: H01J61/04
Filed: 1992-02-13
Granted: 1996-12-19
Abstract: A mica apertured plate (10, 20) has been developed for the purpose of manufacturing long-life fluorescent tubes in machines with the tubes lying horizontally, where diffusion pumping cannot be performed by the introduction of mercury droplets into the tube, but where it is necessary to purge the tube with alternating tube evacuating steps. In the case of one embodiment, this plate has a circular shape and is provided with slots (12, 13) which extend from the periphery of the circular plate in towards a central hole (11), such as to form intermediate tongues (14). The apertured plate is supported by support devices (8, 9) at a constant distance from the lamp electrode (3), such as to form between the plate (10) and the lamp tube a gap in which electrons and ions of the emission material released from the electrode (3) recombine. In another embodiment, the apertured plate (20) is oval and is provided with a central hole (21) and with a recess (23) which is located in the edge of the plate and in which support devices can engage. <IMAGE>
Patent DE-69211087-T2 (DE)
Inventor: KEMPNER JAMES SZKOLNIK
IPC: C08L33/00
Filed: 1992-09-30
Granted: 1997-01-30
Abstract: Core/shell additives, useful in modifying the processing and/or physical properties of poly(vinyl chloride) and other thermoplastic matrix polymers, are prepared separately at small particle sizes by emulsion polymerization, co-agglomerated, further encapsulated by a final shell, and isolated by spray-drying or coagulation. The isolated powders are readily re-dispersed to their original particle sizes in the matrix polymer.
Patent DE-69218604-T2 (DE)
Inventor: GOLDSWAIN IAN MARTYN
IPC: F16J15/34
Filed: 1992-01-24
Granted: 1997-07-03
Abstract: A mechanical face seal includes a first sealing ring (12) mounted non-rotatably and sealed with respect to a shaft (10) and a second sealing ring (20) mounted non-rotatably and sealed with respect to a housing (11), the second sealing ring (20) being mounted in axial alignment with the first sealing ring (12) and springs (30) being provided to urge sealing faces (32, 33) of the first and second sealing rings (12, 20) into sealing engagement. The sealing face (33) of the first sealing ring (12) is provided with a plurality of grooved areas (40) spaced angularly around its circumference, the grooved areas (40) opening to one edge of the sealing face (33), a continuous annular dam formation (41) being provided between the grooved areas (40) and the other edge of the sealing face (33). Each grooved area (40) defines at least two trailing edges (AB, EF) relative to rotation in one direction, the trailing edges (AB, EF) being defined by walls of the grooved area (40) inclined in the plane of the face (33) at an obtuse angle ( alpha ,  alpha ') to said direction of rotation, the trailing edges (AB, EF) each being terminated by a transverse wall (BE, EC) extending circumferentially of the seal face (33). <IMAGE>
Patent DE-69220917-T2 (DE)
Inventor: INBAR MICHAEL
IPC: G01N1/10
Filed: 1992-12-10
Granted: 1998-09-10
Abstract: In the performance of density gradient centrifugation back mixing after centrifugation is prevented by placing a snugly fitted layering insert within the vessel. The insert is capable of supporting the body of liquid dispersion to be centrifuged under regular gravity condition and enables bi-directional cross-flow during centrifugation. A small mesh filter plate may be placed on top of the layering insert. <IMAGE>
Patent DE-69223015-T2 (DE)
Inventor: NIX MICHAEL A
IPC: G06F7/76
Filed: 1992-08-19
Granted: 1998-06-10
Abstract: A system for converting a floating point n-bit signed magnitude binary number to a fixed point two's compliment binary number having m bits wherein m is greater than n, first converts the n bit signed magnitude binary number to a corresponding n-bit two's compliment binary number. Thereafter, a shifter shifts the n-bit two's compliment binary number to the left or right and by a number of bits responsive to received shift decode signals for providing the final fixed point m-bit two's compliment binary number.
Patent DE-69223643-T2 (DE)
Inventor: ROCKENFELLER UWE
IPC: C09K5/04
Filed: 1992-09-04
Granted: 1998-05-07
Abstract: Apparatus for cooling components or subassemblies of equipment at one or more locations comprises a first reactor located at a remote location from said equipment, and a second reactor located in heat exchange communication with a component or subassembly of said equipment, each of said first or second reactors containing a different complex compound of a polar refrigerant and a metal salt, wherein the equilibrium temperature of the complex compound in said first reactor differs from the equilibrium temperature of the complex compound in said second reactor by between about 10 DEG  C. and about 150 DEG  C. at the same operating pressure, heating means for heating a complex compound in said first reactor, and conduit means for directing polar refrigerant between said reactors.
Patent DE-69233685-T2 (DE)
Inventor: TOBIN ALLAN J
IPC: C12N9/04
Filed: 1992-06-17
Granted: 2007-12-06
Abstract: The present invention relates to the use of recombinant DNA technology for the transformation of a host organism with glutamic acid decarboxylase65 (GAD65) for the expression of GAD65 polypeptides. Also encompassed are methods of using GAD65 polypeptides diagnostically and therapeutically in autoimmune disease.
Patent DE-69233691-T2 (DE)
Inventor: OSHLACK BENJAMIN
IPC: A61K47/44
Filed: 1992-11-25
Granted: 2008-01-24
Abstract: (A) Controlled release oxycodone formulation for oral admin. to human patients, comprises (i) 10-40mg oxycodone or its salt, the formulation providing a mean max. plasma conc. of oxycodone of 6-60 ng/ml from a mean of 2-4.5 hrs.. After admin., and a mean min. plasma conc. of 3-30 ng/ml from a mean of 10-14 hrs. after repeated admin. every 12 hrs. through steady state conditions. (ii) 10-160 mg oxycodone or its salt, the formulation providing a mean max. plasma conc. of oxycodone of 6-240 ng/ml from a mean of 2-4.5 hrs. after admin., and a mean min. plasma conc. from 3-120 ng/ml from a mean of 10-14 hrs. after repeated admin. every 12 hrs. through steady-state conditions. (B) Also claimed is a solid controlled release oral dosage form comprising (i) oxycodone or its salt in amt. of 10-160 mg; a controlled release matrix selected from hydrophilic hydrophobic polymers, digestible opt. substd. 8-50C hydrocarbons, and/or polyalkylene glycols; and a diluent; wherein the compsn. provides a mean max. plasma conc. of oxycodone of 6-240 ng/ml from a mean of 2-4.5 hrs. after admin, and mean min. plasma conc. of 3-120 ng/ml from a mean of 10-14 hrs. after repeated admin. every 12 hrs. through steady-state conditions; or (ii) an analgesically effective amt. of spheroids comprising oxycodone or its salt and either a spheronising agent or an acrylic polymer or copolymer, such that the total dosage of oxycodone in the dosage form is 10-160 mg; a film coating which controls the release of the oxycodone or its salt at a controlled rate in an aq. medium, wherein the compsn. provides an in vitro dissolution rate of the dosage form.
Patent DE-69301284-T2 (DE)
Inventor: PUSINERI LUCA
IPC: B08B9/02
Filed: 1993-06-25
Granted: 1996-05-30
Abstract: The present patent of invention refers to a rinsing machine and preferably to a carrousel rinsing machine for treating bottles, vases or the like, which machine is provided with a control device the specific function of which is to determine the point of start for the opening of valves which are arranged along the carrousel machine as well as to determine the point of closing for such valves, there being the possibility of varying the width for the various phases of intervention. In general, the control device of the present machine comprises a series of slider valves (4) which are arranged along the pipes of nozzles (2) and are interested by an opening gear which consists of a roll (14) which is arranged on a piston (11), controlled by a photocell (15), and by an opening gear which consists of a roll (13) which is arranged on a bracket (12) or on a further control piston. Brackets (10) and (12) may be adjusted with a support (9) angularly around the axis of a central shaft on which such brackets are mounted so that both brackets may be positioned in the wished control point. <IMAGE>
Patent DE-69302460-T2 (DE)
Inventor: COLLEGE JOHN W
IPC: B01D53/50
Filed: 1993-06-04
Granted: 1996-09-12
Abstract: A process for removing sulfur dioxide from flue gases where calcium sulfate and magnesium hydroxide are produced, with the magnesium hydroxide separated in an impure state and purified by addition of water thereto to dissolve contaminant calcium sulfate. The calcium sulfate preferentially dissolves to form an aqueous solution and purified magnesium hydroxide is separated therefrom. At least a portion of the resultant aqueous solution of calcium sulfate is returned to the wet scrubbing system as make-up water to replenish water lost from the aqueous medium during scrubbing of the flue gases.
Patent DE-69314990-T2 (DE)
Inventor: CAUWE BRUNO
IPC: C25D3/30
Filed: 1993-03-08
Granted: 1998-12-10
Abstract: Process for electroplating, with high current densities of between 100 and 400 A/dm<2>, preferably between 200 and 300 A/dm<2>, in an electrolysis bath, of tin and/or tin alloys especially of Sn-Pb, Sn-Co and Sn-Ni alloys, on a metal substrate such as a steel strip, according to which an electrolysis bath is employed containing at least one halide, such as chloride, bromide or iodide, of the metal to be deposited on the metal substrate, and stannous and stannic ions, employing an electrolysis bath in which the content of metal ions is maintained between 60 and 150 g/l and is preferably of the order of 115 to 125 g/l in the case of tin plating and of the order of 135 to 145 g/l for the deposition of tin alloys, and in that the electrolyte is circulated at a velocity, relative to the metal substrate, of between 2 and 9 m/s and preferably between 3 and 6 m/s.
Patent DE-69319589-T2 (DE)
Inventor: CAUWENBERGH GERARD FRANS MARIA
IPC: A61K8/49
Filed: 1993-03-16
Granted: 1998-11-26
Abstract: PCT No. PCT/EP93/00634 Sec. 371 Date Sep. 9, 1994 Sec. 102(e) Date Sep. 9, 1994 PCT Filed Mar. 16, 1993 PCT Pub. No. WO93/18744 PCT Pub. Date Sep. 30, 1993.The use of a compound having the formula    <IMAGE>  (I)  or a cosmetically acceptable acid addition salt form thereof, for preventing or reducing irritation or itching of the skin of human beings; cosmetic compositions comprising said agents, processes for preparing said compositions, and a method of preventing or reducing irritation or itching of the skin of human beings.
Patent DE-69323879-T2 (DE)
Inventor: CONNEELY ORLA
IPC: C12N15/80
Filed: 1993-04-16
Granted: 1999-11-04
Abstract: The present invention provides novel plasmids, transfected eucaryotic cells and methods of producing these plasmids and transfected eucaryotic cells. The novel plasmid contains the cDNA for human lactoferrin protein. Methods for the production of human lactoferrin protein in A. Oryzae are also provided. Thus, the present invention provides an efficient and economical means for the production of recombinant human lactoferrin protein.
Patent DE-69332232-T2 (DE)
Inventor: MIZUKOSHI SADANORI
IPC: C07H13/08
Filed: 1993-02-05
Granted: 2003-12-11
Abstract: An immuno-suppressive agent containing, as an effective component, an enopyranose derivative of the following formula (I) or its salt: <CHEM> wherein R<1> is a hydrogen atom, alkyl which may be substituted, alkenyl, alkynyl, -OSO2R<7>, a halogen atom, -OCOR<7>, -NHCOR<8>, alkoxy, phenyl which may be substituted or a saccharose residue, R<2> is a hydrogen atom or alkyl, R<3> is a hydrogen atom or a halogen atom, R<4> is a hydrogen atom, -COR<9>, silyl which may be substituted or alkyl which may be substituted, one of R<5> and R<6> is hydroxyl, alkoxy which may be substituted, a saccharose residue, cycloalkyloxy which may be substituted or -OCOR<1><0> and the other is a hydrogen atom or alkyl which may be substituted, or R<4> and R<5> together form a single bond, while R<6> is a hydrogen atom or alkyl which may be substituted, each of R<7>, R<9> and R<1><0> is alkyl or phenyl which may be substituted, R<8> is alkyl, phenyl which may be substituted or benzyloxy, X is a hydrogen atom, alkyl which may be substituted, alkenyl which may be substituted, alkynyl which may be substituted, cycloalkyl which may be substituted, phenyl which may be substituted, pyridyl which may be substituted, furanyl which may be substituted, thienyl which may be substituted, formyl, -COR<1><1>, -C(W<1>)W<2>R<1><1> or -SO2R<1><1>, R<1><1> is a chain hydrocarbon group which may be substituted, a monocyclic hydrocarbon group which may be substituted, a polycyclic hydrocarbon group which may be substituted, a monocyclic heterocycle group which may be substituted, or a polycyclic heterocycle group which may be substituted, W<1> is an oxygen atom or a sulfur atom, W<2> is an oxygen atom, a sulfur atom or -NH-, Y is a hydrogen atom, alkyl which may be substituted, alkenyl which may be substituted or alkynyl which may be substituted.
Patent DE-69409713-T2 (DE)
Inventor: LANCELLOTTI ADOLFO
IPC: B60B33/02
Filed: 1994-06-24
Granted: 1998-09-17
Abstract: A lockable castor for supporting a movable body, for example, a refuse container, comprises an element (2) for fixing to the movable body, and a fork (3) which supports a rotary wheel (7) and is articulated to the fixing element on a steering axis (A). A resilient brake plate (34) is force-fitted between two facing surfaces belonging, respectively, to a bracket (32) and to an appendage (33) formed by the partial blanking of the bracket. A central, axially-movable operating pin (26) cooperates with the resilient plate (34) to stop the rotation of the wheel (7) and simultaneously cooperates with a toothed disc (29) which engages stops formed in the cheeks (4) of the fork (3) by partial blanking. The fixing element (2) comprises a central polygonal hole (15), an axial shank (20) having a cross-section with a polygonal profile and a peripheral end tooth for the coupling and snap fitting with the central hole (15). <IMAGE>
Patent DE-69410709-T2 (DE)
Inventor: NICODEMO CARLO
IPC: A01B49/00
Filed: 1994-07-20
Granted: 1999-05-20
Abstract: This method consists in marking turfed sports pitches by laying down the strands of the lawn (blades of grass) in certain zones and in raising it (them) up in other zones, so as to form an image and/or a word. The difference in orientation of the strands of the lawn is highly visible to the spectator. The strands are laid down by means of an apparatus mounted on rollers (3) and which rolls over the lawn surface. The same apparatus is provided with brushes (2) which rotate and which stand the strands of lawn up over certain defined sectors (13). The sectors form an image or the letters of a word. The motors (11) which control the path of the apparatus and the brushes (2) are electric and are controlled by a computer, the image to be reproduced and the position of the apparatus on the surface to be treated being stored in the computer. <IMAGE>
Patent DE-69412471-T2 (DE)
Inventor: MILLER STEVEN
IPC: G01T1/10
Filed: 1994-03-07
Granted: 1999-04-29
Abstract: Dose of radiation to which a body of crystalline material has been exposed is measured by exposing the body to optical radiation at a first wavelength, which is greater than about 540 nm, and measuring optical energy emitted from the body by luminescence at a second wavelength, which is longer than the first wavelength. Reduced background is accomplished by more thorough annealing and enhanced radiation induced luminescence is obtained by treating the crystalline material to coalesce primary damage centers into secondary damage centers.
Patent DE-69412812-T2 (DE)
Inventor: OTSUKA YUZO
IPC: B65B51/30
Filed: 1994-05-06
Granted: 1999-01-14
Abstract: A heat seal bar (19) is provided which is free of cutting of a heating ribbon (35) during repeated sealing. The heat seal bar (19) comprises a bar body (31) in the form of an elongated block, an insulating layer (33) which covers the surface of the bar body (31), and a heating ribbon (35) fixed to the surface of the insulating layer (33). A heat pipe (41) is embedded in the bar body (31) to extend along the heating ribbon (35), and maintains the entire heat seal bar (19) uniform in temperature by transferring heat from a portion of a smaller heat load to a portion of a larger heat load in a longitudinal direction of the heat seal bar (19). Accordingly, both end portions and the central portion of the heating ribbon (35) are brought into a steady state in a region of the same temperature as those of the remaining portions, so that the heating ribbon (35) expands uniformly over its entire area to eliminate the generation of such phenomenon that expansion is different between the heating ribbon (35) and the insulating layer (33). <MATH>
Patent DE-69416540-T2 (DE)
Inventor: RUSSEL KEITH
IPC: C07D498/04
Filed: 1994-04-29
Granted: 1999-09-23
Abstract: Compounds of formula I <CHEM> wherein R<1>-R<4>, X, Y, and Z have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful as potassium channel openers for the treatment of urinary incontinence. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
Patent DE-69416848-T2 (DE)
Inventor: HANSEN DONALD
IPC: C07D263/28
Filed: 1994-10-20
Granted: 1999-07-08
Abstract: The current invention discloses useful pharmaceutical compositions containing amidino derivatives of formula (I) as nitric oxide synthase inhibitors. <CHEM>
Patent DE-69417108-T2 (DE)
Inventor: LEHR DAVID ARTHUR
IPC: F27D9/00
Filed: 1994-04-06
Granted: 1999-10-21
Abstract: Hollow hood assembly for handling hot gases from a metallurgical vessel includes a number of sub-assemblies. Each sub-assembly comprises outer (52) and inner (42) surfaces with space (60) between, enclosed by flanges. Spray headers (90), receive water under pressure (118) and hollow spray bars (96) extrude from the header with spray nozzles (100). Liquid is drained from receptacles (110) through outlets (113).
Patent DE-69421015-T2 (DE)
Inventor: NAKAI HIROSHI
IPC: B41J2/01
Filed: 1994-07-21
Granted: 2000-04-13
Abstract: The present invention relates to an information processing apparatus having an information processing section for recording information on a sheet member or reading information therefrom. The information processing apparatus further has a platen disposed in the information processing section, a head member disposed opposite to the platen in the information processing section so as to record information on the sheet member or reading information therefrom, a conveyance mechanism for conveying the sheet member while passing it through the information processing section, and a conveyance passage displacement mechanism for displacing a conveyance passage for the sheet member by reciprocating between the platen side of the conveyance passage and the head member side thereof, the moving amount of the conveyance passage displacement mechanism being variable. The present invention thus can provides an information processing apparatus which can maintain a predetermined distance between the sheet member and the head member. <IMAGE>