baber/WOPTO huggingface dataset:
Patent CY-1117474-T1 (CY)
Title: Θεραπευτικη αγωγη της σκληρυνσης κατα πλακας (ms) me campath-1h
Inventor: SACHSE ANDREAS
IPC: C07K16/28
Filed: 2016-03-01
Abstract: Περιγράφεται μία μέθοδος για την θεραπευτική αγωγή της σκλήρυνσης κατά πλάκας (ΣΚΠ, MS) με το Campath-1Η με σημαντική αποτελεσματικότητα και θετική εικόνα ως προς την ασφάλεια, η οποία προσφέρει μια αποδεκτή αναλογία οφέλους/κινδύνου. Περιγράφεται ειδικά η χρήση του Campath-1Η (αλεμτουζουμάμπη) για την παραγωγή ενός φαρμάκου για την θεραπευτική αγωγή της σκλήρυνσης κατά πλάκας (ΣΚΠ), που περιλαμβάνει έναν πρώτο κύκλο ακολουθούμενο από τουλάχιστον ένα περαιτέρω κύκλο θεραπευτικής αγωγής με Campath-1Η (αλεμτουζουμάμπη), στην οποία κάθε κύκλος θεραπευτικής αγωγής περιλαμβάνει 1-5 ημερήσιες δόσεις, οι οποίες εφαρμόζονται σε διαδοχικές ημέρες, όπου η ημερήσια δόση είναι >0 και ≤ 12 mg, και όπου κάθε κύκλος θεραπευτικής αγωγής απέχει χρονικά από τον επόμενο κύκλο τουλάχιστον 1-24 μήνες. Περιγράφονται επίσης δοσολογικά σχήματα θεραπευτικής αγωγής που περιλαμβάνουν την χορήγηση λιγότερο από 12 mg/ημέρα του Campath-1H για μία περίοδο 1 -5 συνεχόμενων ημερών.
Patent CY-1118017-T1 (CY)
Title: Υποβαλλοντας σε αγωγη την ανεπαρκεια και το ελλειμμα βιταμινης d με 25-υδροξυβιταμινη d2 και 25-υδροξυβιταμινη d3
Inventor: BISHOP CHARLES W
IPC: A61P3/02
Filed: 2016-09-15
Abstract: Μέθοδοι και συνθέσεις για την αγωγή της ανεπάρκειας και του ελλείμματος 25-υδροξυβιταμίνης D σε έναν ασθενή περιγράφονται εις το παρόν. Η μέθοδος συμπεριλαμβάνει εκ του στόματος χορήγηση στον ασθενή μιας φαρμακοτεχνικής μορφής καθυστερημένης κατακρατημένης αποδέσμευσης, συμπεριλαμβάνοντας ένα πρώτο συστατικό μείγματος που επιλέγεται από την ομάδα συνιστάμενη από 25-υδροξυβιταμίνη D2, 25-υδροξυβιταμίνη D3, ή έναν συνδυασμό 25-υδροξυβιταμίνης D2 και 25-υδροξυβιταμίνης D3, ή αυτή συμπεριλαμβάνει την κατά βαθμιαίο τρόπο χορήγηση στον ασθενή: μιας στείρας ενδοφλέβιας φαρμακοτεχνικής μορφής συμπεριλαμβάνοντας ένα πρώτο συστατικό μείγματος που επιλέγεται από την ομάδα συνιστάμενη από 25-υδροξυβιταμίνη D2, 25-υδροξυβιταμίνη D3, ή έναν συνδυασμό 25-υδροξυβιταμίνης D2 και 25-υδροξυβιταμίνης D3.
Patent CY-1118912-T1 (CY)
Title: Πηκτωματουμενο κολλαγονο και μεσο για τη διαθεση αυτου
Inventor: GRAEVE THOMAS
IPC: A61L27/52
Filed: 2017-05-30
Abstract: Η εφεύρεση αφορά την παραγωγή και διάθεση πηκτωματούμενης σύνθεσης κολλαγόνου, η οποία σχηματίζει απευθείας μήτρα κολλαγόνου, καθώς και μέσο για την παραγωγή και χρήση αυτού, ιδίως στο πλαίσιο της θεραπείας.
Patent CY-1119124-T1 (CY)
Title: Συνθεσεις νανοσωματιδιων για την παραγωγη ρυθμιστικων τ λεμφοκυτταρων και την αγωγη αυτοανοσων ασθενειων και αλλων χρονιων φλεγμονωδων καταστασεων
Inventor: FREUND BARBARA
IPC: C12N5/0783
Filed: 2017-07-28
Abstract: Η παρούσα εφεύρεση σχετίζεται με νανοσωματίδια για τη στοχευμένη απελευθέρωση αντιγόνου στα κύτταρα του ήπατος, συγκεκριμένα στα ημιτονοειδή ενδοθηλιακά κύτταρα (LSEC) και/ή στα κύτταρα Kupffer και για την in vivo δημιουργία ρυθμιστικών Τ λεμφοκυττάρων, ιδίως CD4+CD25+FOXP3+ ρυθμιστικών Τ λεμφοκυττάρων (Treg). Η εφεύρεση παρέχει φαρμακευτικές συνθέσεις και μεθόδους για την πρόληψη και την αγωγή αυτοάνοσων ασθενειών, αλλεργιών και άλλων χρόνιων φλεγμονωδών καταστάσεων και για τη δημιουργία ρυθμιστικών Τ λεμφοκυττάρων. Τα νανοσωματίδια που χρησιμοποιούνται στην εφεύρεση περιλαμβάνουν a) ένα μικύλλιο που περιλαμβάνει ένα αμφίφιλο πολυμερές που καθιστά το νανοσωματίδιο υδατοδιαλυτό και b) ένα πεπτίδιο που περιλαμβάνει τουλάχιστον έναν επίτοπο Τ λεμφοκυττάρων που σχετίζεται με το εξωτερικό του μικυλλίου. Το μικύλλιο μπορεί ή μπορεί να μην περιλαμβάνει έναν συμπαγή υδρόφοβο πυρήνα.
Patent CY-1119828-T1 (CY)
Title: Φαρμακευτικες συνθεσεις που περιεχουν εκλεκτικους συνδετες υποδοχεα ντοπαμινης και μεθοδοι θεραπειας χρησιμοποιωντας εκλεκτικους συνδετες υποδοχεα ντοπαμινης
Inventor: ADHAM NIKA
IPC: A61P25/24
Filed: 2017-12-07
Abstract: Η παρούσα εφεύρεση αφορά σε φαρμακευτικές συνθέσεις που περιέχουν εκλεκτικούς συνδέτες υποδοχέα ντοπαμίνης και εκλεκτικούς αναστολείς επαναπρόσληψης σεροτονίνης και σε μεθόδους θεραπείας διαταραχών όπως σχιζοφρένειας, κύριας καταθλιπτικής διαταραχής και διπολικής κατάθλιψης χρησιμοποιώντας συνδυασμούς εκλεκτικών συνδετών υποδοχέα ντοπαμίνης και εκλεκτικών αναστολέων επαναπρόσληψης σεροτονίνης. Η παρούσα εφεύρεση επίσης αφορά σε μεθόδους θεραπείας κατάθλιψης χρησιμοποιώντας εκλεκτικούς συνδέτες υποδοχέα ντοπαμίνης.
Patent CY-1124537-T1 (CY)
Title: Παραγωγο πυριδονης που εχει τετραϋδροπυρανυλ μεθυλ ομαδα
Inventor: HAGINOYA NORIYASU
IPC: C07D405/14
Filed: 2021-06-30
Abstract: Προορίζεται να παρέχει νέα ένωση ή άλας αυτής, ή κρυστάλλους της ένωσης ή του άλατος, οι οποίοι αναστέλλουν ΑxI και είναι χρήσιμοι στη θεραπεία ασθένειας που προκαλείται από υπερλειτουργία της ΑxI, στη θεραπεία ασθένειας που συνδυάζεται με υπερλειτουργία της ΑxI, ή/και στη θεραπεία ασθένειας που ενέχει υπερλειτουργία της ΑxI. [Λύση] Η παρούσα εφεύρεση παρέχει παράγωγο πυριδόνης που έχει τετραϋδροπυρανυλμεθύλ ομάδα που αντιπροσωπεύεται με τον ακόλουθο τύπο (Ι) που έχει διάφορους υποκαταστάτες, ή άλας αυτών, ή κρυστάλλους της ένωσης ή του άλατος (όπου R1, R2, R3, R4, R5, W, Χ, Υ, και Ζ εκάστη είναι όπως ορίζεται στην περιγραφή).
Patent GR-890300185-T1 (GR)
Title: Fluorescent indicator dyes for calcium working at long wavelengths
Inventor: TSIEN ROGER YONCHIEN
IPC: C09B57/00
Filed: 1990-10-31
Abstract: A new class of calcium specific fluorescent indicator dyes having visible excitation and emission wavelengths combine at least one tricyclic chromophore with a tetracarboxylate parent CA<2><+> chelating compound having the octacoordinate pattern of liganding groups characteristic of BAPTA to give a rhodamine-like or fluorescein-like fluorophore. Binding of calcium<2><+> increases the fluorescence of the new compounds by up to 40-fold. The calcium<2><+> dissociation constants are in the range 0.37-2.3 microM, so that the new indicators give better resolution of high [CA<2><+>] levels than were previously obtainable with predecessor compounds such as quin-2 or fluo-2. The visible excitation wavelengths of the new compounds are more convenient for fluorescent microscopy and flow cytometry than the UV required by previous indicators.
Patent HR-P20110050-T1 (HR)
Inventor: FISCHER ANDREAS
IPC: A61K31/135
Filed: 2011-01-24
Abstract: Kristalni oblik A (-)-(1R,2R)-3-(3-dimetilamino-1-etil-2-metilpropil)-fenol hidroklorida koji pokazuje barem linije rendgenskog spektra (2-theta vrijednosti) u difrakcijskom uzroku na prahu kad je mjeren pomoću Cu K? zračenja na 15.1±0.2, 16.0±0.2, 18.9±0.2, 20.4±0.2, 22.5±0.2, 27.3±0.2, 29.3±0.2 i 30.4±0.2 za upotrebu kao aktivnog sastojka u farmaceutskim sastavima. Patent sadrži još 4 patentna zahtjeva.
Patent HR-P20120270-T1 (HR)
Title: A cartridge
Inventor: HAKAN CEVAT TUNKAY
IPC: F16K11/20
Filed: 2012-03-26
Abstract: The present invention relates to a cartridge which comprises separate temperature and flow adjusting shafts whereby temperature and flow adjustments can be controlled separately from each other and where, if desired, the flow adjusting cartridge (3) and the temperature adjusting cartridge (4) can be separated from each other to be used in different mechanisms independent of each other.
Patent SI-1574643-T1 (SI)
Title: Electromechanical lock cylinder
Inventor: KELLER ERNST
IPC: E05B9/04
Filed: 2004-03-11
Abstract: The electromechanical cylinder lock has a cylinder (1) with a first half (2) housing (5) on the outside of the door and a rotor (7) with a slot (8) for a security radio key. A connection piece (10) joins the first cylinder housing with a housing (6) for a second cylinder half on the inside of the door. There may be length adjustment pieces (16). There is a hand knob (24) on the inside containing electronic control circuits, connected to the outer cylinder housing.
Patent SI-1743512-T1 (SI)
Title: Automatised assembly operating unit in particular for aerosol appliances
Inventor: ABATE RICARDO
IPC: H05K5/00
Filed: 2005-03-24
Abstract: The invention concerns an operating unit to generate a flow of air under pressure in aerosol therapy equipment, comprising a pump group (12) powered by a motor and having a head (19), with an air inlet duct (22) complete with filter (24) and an air outlet duct (23). The pump group is enclosed in a body made up of two shells, top and bottom, (13, 14) which overlap and fit together on a transversal plane at the level of their edges. The shells forming the body receive and hold the air inlet duct (22) with filter, the air outlet duct (23) and a plate with socket and switch following their overlapping for automizable assembly of the group.
Patent TR-200606947-T1 (TR)
Inventor: HASANREISOGLU LEVENT
IPC: A47G19/14
Filed: 2005-06-15
Abstract: This invention relates to a coffee machine (1), which is designed with the inspiration of conventional cooking methods, which is used to cook Turkish coffee in a short period of time in accordance with its traditional flavor and consistency wherein means are provided to prepare different types of Turkish coffee without getting them mixed up, especially in crowded places such as hotels, restaurants or cafes where there is a continuous demand for various types of Turkish coffee, as more than one cooking chamber (4) is utilized.
Patent TR-201804946-T1 (TR)
Title: Yaprak ve yaprağın üretimi için yöntem.
Inventor: BIN LATIF MUHAMAD NOR SALEHUDDIN
IPC: A61F13/53
Filed: 2016-10-06
Abstract: Buluşun bir absorban maddesi için bir yaprak şeklinde madde (1) çok sayıda absorban birimi (4) içerir, bunların her biri; bir uzun taban kısmı (2) ve uzun taban kısmının (2) bir yüzünün bir yüzeyine sabitlenen su-absorban polimer partiküllerini (3) içerir. Yaprak şeklinde maddede (1), absorban birimleri (4), uzunlama doğrultusunun bir doğrultuda yönlendirildiği şekilde düzenlenir. Su-absorban polimer partikülleri (3) bir sıvıyı absorbe etmeden önce, su-absorban polimer partikülleri (3), uzunlama doğrultusu boyunca genişleyen uzun taban kısmının (2) her iki yanal kenar uç kısımlarının (2s) dış kısmında yer alır. Su-absorban polimer partikülleri (3) bir sıvıyı absorbe ettiğinde, su-absorban polimer partikülleri (3); uzunlama doğrultusu boyunca genişleyen uzun taban kısmının (2) yanal kenar uç kısımlarının (2s) ötesine kabarır ve her uzun taban kısmının kalınlık doğrultusundaki bir pozisyon, sıvının absorbe edilmesinden önceki pozisyonundan farklıdır. Şekil 1
Patent DE-3587672-T2 (DE)
Inventor: SUGERMAN GERALD
IPC: C07F7/28
Filed: 1985-09-11
Granted: 1994-04-14
Abstract: 57 The invention relates to a new process for producing titanium IV and zirconium IV pyrophosphates, certain of which are new compounds, and their uses. The pyrophosphates are prepared by reacting a metal tetraester with phosphorus pentachloride, with or without the addition of an hydroxyl compound, such as an alcohol or a phenol. Depending on the molar ratio of the components, the compounds produced may contain cyclic or straight chain pyrophosphate groups and alkoxy groups attached to the metallic ion. In addition to forming new compounds, the process of the invention produces the desired products without difficult-to-separate by-products. The products of the invention are useful as flame-retardants, antioxidants, coupling agent, impact modifiers and processing aids, and the reaction for their preparation may be represented as follows:wherein M is titanium or zirconium; R is a monovalent hydrocarbon group optionally substituted with halogen or oxygen substituents; n is an integer from 1 to 4; m is an integer from 0 to 4; x is an integer from 0 to 2; q is an integer from 0 to 4; n is greater than or equal to m; n = p + m + q; x + m + 2p + q <sub>=</sub> 4; and when x is greater than 0, q is 0.
Patent DE-3687399-T2 (DE)
Inventor: SAKATA ISAO
IPC: A61K31/43
Filed: 1986-10-23
Granted: 1993-04-29
Abstract: A porphyrin compound of the formula:wherein R<sub>1</sub> and R<sub>2</sub> are each -CH=CH<sub>2</sub>, -CH<sub>2</sub>CH<sub>3</sub>, -CH(O-lower alkanoyl)CH<sub>3</sub>, -CH(OR)CH<sub>3</sub> or -CH(O-lower alkylene-OR)CH<sub>3</sub>; R<sub>3</sub> is -H, -COOH, -COO-lower alkyl, -COO-lower alkylene-OR or -COO-lower alkylene -OOC-Z; R<sub>4</sub> is -H, -lower alkyl or -lower alkylene-OR; R is -H, -lower alkyl or a residue of a polyfunctional carboxyl compound exluding a hydrogen atom therefrom; Z is a residue of the compound of the formula (I) excluding R<sub>3</sub> therefrom; A is -CH<sub>2</sub>- or-CO-; and the dotted line from the gamma-position indicates no bonding or a single direct bond; and the dotted line between the 7- and 8-positions indicates the presence of a single bond or a double bond; and its complexes with a metal(s) in the porphine skeleton and/or at the residue of the polyfunctional carboxyl compound, at least one of R<sub>1</sub>, R<sub>2</sub>, R<sub>3</sub> and R<sub>4</sub> being a group containing R which represents the residue of the polyfunctional carboxyl compound and R<sub>1</sub> being capable of representing 1-iodoethyl in addition to said meanings when R<sub>3</sub> is -COO-lower alkylene-OOC-Z, which shows a high accumulation in the locus of cancer with quick excretion from normal tissues.
Patent DE-3855204-T2 (DE)
Inventor: AWAD SAMI B
IPC: C23C26/00
Filed: 1988-05-31
Granted: 1996-11-07
Abstract: A process for the production of aluminum cans to be used as beverage containers, in which the formed cans are cleaned with liquid acidic or alkaline cleaners to remove aluminum fines and other contaminants from at least the outside of said cans, the thus-cleaned cans are dried, and the dried cans are thereafter conveyed along a production line towards a station at which the thus-cleaned-and-dried cans are printed, lacquered and/or filled, in which in order to enhance the mobility of the cans along the production line one reduces the high coefficient of static friction of the dried exterior surface of the cans without preventing the adhesion of lacquer or printing ink thereto by applying to the exterior surface of the cans, before the last drying before the cans are printed, lacquered and/or filled, a water-soluble organic surface conditioner so as to form a film of the latter on the exterior surfaces of the dried cans.
Patent DE-3882528-T2 (DE)
Inventor: DE MARCH GHISLAINE
IPC: C12N5/00
Filed: 1988-09-19
Granted: 1993-11-11
Abstract: To produce substances of vegetable origin, a vegetable organ is implanted in a culture medium and is kept under hypoxia by immersion beneath a layer of oil and the substances produced are extracted from the organ, the medium and/or the oil.
Patent DE-3885627-T2 (DE)
Inventor: WESTBROOK LESLIE DAVID
IPC: H01L33/00
Filed: 1988-02-18
Granted: 1994-05-19
Abstract: A laser structure with highly p-doped active material is described which has a particularly low linewidth enhancement factor  alpha . Hence the emission linewidth of the laser structure 1 is relatively small. The structure 1 shows a particular relationship between the photon energy E, the band gap energy Eg and the conduction band quasi Fermi level Efc of the active material which minimises  alpha , the valence band being degenerate. These conditions can be used to design low alpha laser structures. Structures according to embodiments of the invention are of particular application to directly modulated lasers or absorption modulators and also find application in coherent optical detection.
Patent DE-3889505-T2 (DE)
Inventor: AEGIDIUS POUL ERIK
IPC: G01N33/12
Filed: 1988-05-19
Granted: 1994-08-25
Abstract: A method for substantially selectively removing adenosine triphosphate (ATP) from somatic cells in a sample containing somatic cells and bacteria comprising treating the sample with water to rupture the membranes of the somatic cells, and substantially removing or inactivating the ATP released. The treatment with water is preferably carried out in a water layer above the surface of a substrate material, in particular a filter material such as a membrane filter. Also a method for determining the number of bacteria on the surface of a substrate, said method comprising   a) forming a closed chamber having an inner wall which is partly defined by the bacteria-bearing surface of the substrate; b) contacting the bacteria-bearing surface with an aqueous extraction medium capable of perforating the cell walls of the bacteria and extracting substantially all of the ATP present in the bacteria; c) transferring the extraction medium to a separate measuring chamber; d) adding luciferine and luciferase to the extraction medium so as to subject the ATP in the extraction medium to a luciferine/luciferase reaction; and e) determining the amount of ATP by measuring in the measuring chamber the light emitted as a result of the reaction and expressing the amount of ATP as the number of bacteria present on the substrate.   m
Patent DE-3889753-T2 (DE)
Inventor: YANG TAI-HER
IPC: H02P1/42
Filed: 1988-01-18
Granted: 1994-09-08
Abstract: Induction motor apparatus has a driving winding (WR1) and a starting winding (WS1), a starting switch (SS1) connected in series with the starting winding (WS1) and a phase shifting or splitting element (Z1) coupled in parallel with the switch (SS1). The combustion of the starting winding (WS1), the starting switch (SS1) and the element (Z1) are coupled in parallel with the driving winding (WR1).
Patent TR-199800894-T2 (TR)
Inventor: GILIS PAUL MARIE VICTOR
IPC: A61K9/20
Filed: 1996-12-20
Abstract: The present invention is concerned with bioadhesive pharmaceutical compositions comprising a pharmaceutically effective amount of an active ingredient, from 80% to 98.8% (w/w/) pre-gelatinized starch, and from 1% to 10% (w/w) of a hydrophilic matrix forming polymer, characterized in that the composition further comprises from 0.2% to 5% (w/w) alkaliC16-22alkyl fumarate as a lubricant; solid dosage forms such as tablets which are suitable for oral, nasal, rectal and vaginal administration; processes of preparing the compositions and solid dosage forms.
Patent TR-199901094-T2 (TR)
Inventor: ELLIOTT ISAAC K
IPC: H04M11/06
Filed: 1997-11-14
Abstract: Telefon görüsmeleri, veri ve baska multimedya bilgileri, internet üzerinden bilgilerin transferini de içeren bir melez iletisim agi yoluyla yönlendirilmektedir. Bir ortam talimat girisi bir kullanici için olan bütün kullanici profil bilgilerini almaktadir. Bu profil bilgi sistem tarafindan yönlendirme, faturalama, monitörleme, raporlama için ortam deneyimlerinde ve baska ortam kontrol islevlerinde kullanilmaktadir. Kullanicilar bir iletisim aginin daha önce mümkün olandan daha fazla yönünü idare edebilmekte ve bir merkezi sisteden iletisim agi aktivitelerini kontrol edebilmektedir.
Patent TR-199901462-T2 (TR)
Inventor: BOLTE GERD
IPC: C08G18/76
Filed: 1997-12-18
Abstract: A low-monomer PU prepolymer containing free NCO groups which is obtained from polyhydric alcohols and diisocyanates differing in their reactivity and which is distinguished by the ratio of the NCO groups of the partly slower-reacting diisocyanate to the NCO groups of the faster-reacting diisocyanate. It is greater than 6:1. Nevertheless the prepolymer according to the invention cures more quickly than a known prepolymer predominantly containing fast-reacting NCO groups. In a preferred embodiment, TDI is used as the partly slower-reacting diisocyanate while MDI is used as the faster-reacting diisocyanate. The prepolymer is produced in two stages. The prepolymer according to the invention is suitable for bonding plastic articles, metals and paper, especially films. The accelerated absence of migration is particularly noticeable in this regard.
Patent DE-60002327-T2 (DE)
Inventor: MORRISON P
IPC: G06F9/45
Filed: 2000-05-26
Granted: 2004-02-12
Abstract: Inferring operand types within an intermediate language is disclosed. In one embodiment, a computer-implemented method first inputs an intermediate language code that has a first plurality of opcodes, including a type-indefinite opcode. The method resolves the type-indefinite opcode into a typed opcode, and generates a native code that has a second plurality of opcodes corresponding to the first plurality of opcodes, and which includes an opcode corresponding to the typed opcode. The method finally outputs the native code. An example of an intermediate language is Java, etc.
Patent DE-60002917-T2 (DE)
Inventor: CLARK PAUL
IPC: H04N7/173
Filed: 2000-09-20
Granted: 2004-05-13
Abstract: A system is disclosed which provides integrated, personalized access through a television by a large number of viewers to a wide range of on-demand media content, by use of distributed storage and discovery techniques, user authentication and a personalized user interface.
Patent DE-60004019-T2 (DE)
Inventor: GORMAN R
IPC: B29C59/04
Filed: 2000-02-11
Granted: 2004-04-22
Abstract: Tool rolls and methods of using the tool rolls to manufacture articles with one or more structured surfaces are disclosed. The tool rolls include an outer surface that, when used in connection with materials of the proper viscosity or formability, can form a structured surface on an article. Because the tools are manufactured in roll-form, they can be advantageously used in continuous manufacturing processes. Alternatively, discrete articles may be processed using the tool rolls. The tool rolls are constructed of a cylindrical base roll and are wrapped with one or more continuous wires in a helical pattern. The wires are used, in essence, to form a structured surface on the tool roll that is the negative of the structured surface to be formed on the articles processed using the tool roll. One of the wires wound around the base roll may include a plurality of voids formed therein that, when wound in helical coils about the base roll, form a plurality of mold cavities on the outer surface of the tool roll. Alternatively, the helical pattern of one or more wound wires may be used to form a continuous helical structured surface, e.g., a helical groove or grooves.
Patent DE-60005982-T2 (DE)
Inventor: SPENCE EDWARD VON HAKEN
IPC: C08F4/64
Filed: 2000-08-24
Granted: 2004-09-09
Abstract: New group 4 organometallic complexes are characterized by having a phosphinimine ligand and two or more cyclopentadienyl ligands. Certain of these complexes exhibit unusual behavior when examined by nuclear magnetic resonance (NMR) techniques. Well defined crystals of the inventive complexes have been isolated and analyzed by x-ray crystallography. The complexes have also been found to be polymerization catalysts which are surprisingly more active than their simple metallocene analogs.
Patent DE-60008368-T2 (DE)
Inventor: SMITH PETER
IPC: A61K39/00
Filed: 2000-05-19
Granted: 2004-12-09
Abstract: New vaccines for use as immunotherapeutic agents in the treatment of cancer, particularly but not limited to prostate cancer, are described. The invention relates to cell co-culture techniques which leads to a significant enhancement of the phenotype of cell lines, particularly allogeneic cell lines, towards a more <i>in vivo</i> phenotype resulting in a vaccine reflecting a more realist phenotypic representation of an <i>in vivo</i> tumour. Further, the invention relates to whole cell cancer vaccines having an immunogenic component which comprises co-cultured malignant and non-malignant cells. Such vaccines produced by the various co-culture techniques described have additional advantages over single cell suspension vaccines in the mode of presentation to the immune system which leads to enhanced performance in treating the disease.