Patent SG-11201804398X-A (SG)
Title: Method for producing rna molecule compositions
Inventor: ROOS TILMANN
IPC: A61K39/00
Filed: 2016-12-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 29 June 2017 (29.06.2017) WIPOIPCT (10) International Publication Number WO 2017/109134 A1 (51) International Patent Classification: A61K38/00 (2006.01) A61K 48/00 (2006.01) A61K39/00 (2006.01) (21) International Application Number: PCT/EP2016/082487 (22) International Filing Date: (25) Filing Language: (26) Publication Language (30) Priority Data: PCT/EP2015/081000 22 December 2016 (22.12.2016) English English 22 December 2015 (22.12.2015) EP (71) Applicant: CUREVAC AG [DE/DE]; Paul-Ehrlich-Str. 15, 72076 Tubingen (DE). (72) Inventors: ROOS, Tilmann; Kirchentellinsfurter Strasse 16, 72127 Kusterdingen (DE). KUNZE, Martin; Gelber Kreidebusen 31, 72108 Rottenburg (DE). YAZDAN PA- NAH, Benyamin; Goethestrasse 11, 72076 Tubingen (DE). YILMAZ, Salih; Untere Hohbergstr. 18, 72074 Tubingen (DE). CONZELMANN, Markus; Steinlach- allee 24, 72072 Tubingen (DE). (74) Agent: MAIWALD PATENTANWALTS GMBH; Dr. Andrea Lasar, Elisenhof, Elisenstrasse 3, 80335 Munich (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). [Continued on next page] (54) Title: METHOD FOR PRODUCING RNA MOLECULE COMPOSITIONS Figure 6 I < Tf WMMMMiMI ON t $ r <? (57) : The invention relates to a method for producing ribonucleic acid a (RNA) molecule composition compris­ ing n different RNA molecule species, the method comprising step of RNA a in vitro transcription of mixture of a m dif­ ferent deoxyribonucleic acid (DNA) molecule species in a single reaction vessel in parallel, i.e. simultaneously, and a step of obtaining the RNA mo­ lecule composition. Also provided is the RNA composition provided by the in­ ventive method and a pharmaceutical composition comprising the same as well as a pharmaceutical container. Moreover, the invention provides the RNA composition and the pharmaceut­ ical composition for use as medicament. WO 2017/109134 A11II llll IIII III III Hill III III III 111 Hill lllll llll 111 llll mill llll 111 III Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))