baber/WOPTO huggingface dataset:
Patent NZ-602702-A (NZ)
Title: Modified fgf-21 polypeptides and their uses
Inventor: CUJEC THOMAS P
IPC: A61K38/18
Filed: 2008-03-19
Abstract: Patent No. 602702 Disclosed is a modified FGF-21 polypeptide that maintains a biological activity of an unmodified human FGF-21 polypeptide, wherein said modified FGF-21 polypeptide comprises an amino acid sequence that: (i) is between 85% identical and 90% identical to a sequence set forth in HPIPDSSPLLQFGGQVRQRYLYTDDAQQTEAHLEIREDGTVGGAADQSPESLLQLKALKPGVIQILGVKTSRFLCQRPDGALYGSLHFDPEACSFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRDPAPRGPARFLPLPGLPPAPPEPPGILAPQPPDVGSSDPLSMVGPSQGRSPSYAS; and (ii) comprises at least one non-naturally encoded amino acid each of which is at a position corresponding to residue 72, 77, 86, 87, 91, 104, 108, 110, 126, 131, or 146 of HPIPDSSPLLQFGGQVRQRYLYTDDAQQTEAHLEIREDGTVGGAADQSPESLLQLKALKPGVIQILGVKTSRFLCQRPDGALYGSLHFDPEACSFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRDPAPRGPARFLPLPGLPPAPPEPPGILAPQPPDVGSSDPLSMVGPSQGRSPSYAS.
Patent NZ-602978-A (NZ)
Title: Compositions of small molecule therapeutics
Inventor: DAMAJ BASSAM B
IPC: A61K31/335
Filed: 2011-05-04
Abstract: Disclosed are compositions containing a small molecule therapeutics and an alkyl N, N-disubstituted amino acetate are disclosed. Inclusion of the alkyl N, N-disubstituted amino acetate enhances the pharmacokinetic properties of the small molecule therapeutics. In particular the disclosure is directed towards taxanes as the small molecule therapeutic and dodecyl-2-(N,N-dimethylamino) isopropionate hydrochloride as the enhancer.
Patent NZ-603014-A (NZ)
Title: Stabilized agricultural oil dispersions
Inventor: LI MEI
IPC: A01N25/04
Filed: 2011-04-26
Abstract: The disclosure relates to an oil dispersion of improved stability consisting essentially of: (a) an aprotic organic solvent comprising, with respect to the total composition, from 200 g/L to 999 g/L, wherein the aprotic organic solvent may be selected from petroleum distillates, vegetable oils, C1-C6 dialkyl amides of C6-C20 saturated and unsaturated aliphatic carboxylic acids; C1-C12 esters of aromatic carboxylic acids and dicarboxylic acids and C1-C12 esters of aliphatic and cyclo-aliphatic carboxylic acids; C4-C12 polyesters of dihydric, trihydric, or other lower polyalcohols such as, propylene glycol dioleate, di-octyl succinate, di-butyl adipate, di-octyl phthalate; (b) a polymer or oligomer capable of hydrogen bonding comprising, with respect to the total composition, from 1 g/L to 200 g/L, wherein the polymer or oligomer capable of hydrogen bonding comprises at least one of a polyethylene glycol or polypropylene glycol; (c) a dispersed active ingredient comprising, with respect to the total composition, from 1 g/L to 700 g/L, wherein the dispersed active ingredient comprises at least one herbicide selected from the classes of sulfonamides, sulfonylureas, arylpyridine carboxylic acids, arylpyrimidine carboxylic acids, hydroxybenzonitriles, anilides, imidazolinones, carbazones and derivatives thereof; (d) a clay or silica type rheology modifier comprising, with respect to the total composition, from 1 g/L to 200 g/L; and (e) at least one surfactant comprising, with respect to the total composition, from 1 g/L to 600 g/L.
Patent NZ-616497-A (NZ)
Title: A kite fishing system
Inventor: MARTIN LIEBENBERG
IPC: A01K91/18
Filed: 2013-10-11
Abstract: 616497 Disclosed are a kite fishing system (1) and a kit of parts which can be readily assembled into a kite fishing system (1). Current kite fishing systems are difficult to use as secondary fishing lines are required to be cast using the same main line and the reliability of the system varies based on wind conditions. The kite fishing system (1) comprises a first kite (2); a stopper (5) and a taxi kite assembly (6). The first kite (2) and associated first kite line (3) is attached at one end to a fishing rod (4). The stopper (5) is attached to the first kite line (3) at a predetermined distance between the fishing rod (4) and first kite (2). The taxi kite assembly (6) comprises a taxi-kite attached to a support rod (8). The support rod (8) is configured to move on the first kite line (3) between the fishing rod (4) and the stopper (5) when the first kite (2) and taxi kite are airborne. The taxi kite assembly (6) further comprises a release assembly (10) which is configured to suspend and release a fishing load, including a fishing line and sinker, when the support rod (8) contacts the stopper (5). The taxi kite assembly (6) also comprises a sail which is configured to fold up when the support rod (8) contacts the stopper (5) allowing the support rod (8) to travel on the first kite line (3) between the stopper (5) and the fishing rod (4).
Patent NZ-700328-A (NZ)
Title: Methods and apparatus for preventing rainout
Inventor: MALOUF GORDON JOSEPH
IPC: A62B9/02
Filed: 2011-09-02
Abstract: A device to accumulate supplemental oxygen in a respiratory treatment apparatus, the device comprising: a gas conduit having an input aperture and an output aperture, the gas conduit configured as a channel (4106) for movement of a gas between the input aperture and the output aperture, the input aperture configured to receive gas output from a blower of the respiratory treatment apparatus, the output aperture configured to convey gas to a patient interface from the blower, the gas conduit including a supplemental oxygen input (4200) proximate to the output aperture; and a barrier (4110) in the channel between the input aperture and the output aperture of the gas conduit, the barrier operable to selectively prevent vapor passing from the output aperture to the input aperture. The barrier is further configured to permit accumulation of supplemental oxygen in the gas conduit by reducing back flow of the supplemental oxygen during user expiration.
Patent NZ-702939-A (NZ)
Title: Process for making amino acid compounds
Inventor: REMARCHUK TRAVIS
IPC: C07C271/22
Filed: 2013-05-17
Abstract: The invention provides new processes for making and purifying amino acid compounds, which are useful in the preparation of AKT inhibitors used in the treatment of diseases such as cancer, including the compound (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one.
Patent NZ-704799-A (NZ)
Title: Heterocyclic modulators of hif activity for treatment of disease
Inventor: JONES PHILIP
IPC: C07D263/02
Filed: 2013-08-23
Abstract: The present invention relates to compounds of Formula (III), pharmaceutical compositions comprising these compounds, and uses of these compounds in the preparation of medicament for the treatment of cancer and other HIF pathway-mediated diseases. In particular aspects, the invention relates to a compound of structural Formula III: or a salt thereof, wherein: X2 and X4 are N and X5 is O; X4 and X5 are N and X2 is O; X2 and X5 are N and X4 is O; X2 is CH, X4 is N, and X5 is O; or X2 is CH, X4 is O, and X5 is N; Z2 is selected from the group consisting of N and CR14; R1 is selected from the group consisting of ; R14, R39, and R40 are independently selected from the group consisting of hydrogen, deuterium, halogen, alkyl, haloalkyl, perhaloalkyl, cyano, hydroxy, alkoxy, haloalkoxy, perhaloalkoxy, alkylthio, amino, and saturated 3- to 7-membered cycloalkyl, any of which may be optionally substituted; and R18 is selected from the group consisting of alkyl, haloalkyl, perhaloalkyl, alkoxy, haloalkoxy, perhaloalkoxy, alkylthio, haloalkylthio, and perhaloalkylthio.
Patent NZ-726448-A (NZ)
Title: Improved immunoglobulin variable domains
Inventor: BOUTTON CARLO
IPC: C07K16/28
Filed: 2015-05-13
Abstract: Heavy-chain immunoglobulin single variable domain (ISVD), in which the amino acid residue at position 11 is V and the amino acid residue at position 110 is one of K or Q, (the amino acid positions are indicated with the numbering according to Kabat); preferably, said heavy-chain ISVD contains a C-terminal extension (X)n, in which n is 1 to 10; more preferably, n is 1 to 5, such as 1, 2, 3, 4 or 5; and each X is an amino acid residue that is independently chosen.
Patent NZ-726749-A (NZ)
Title: Building or construction and method for production thereof
Inventor: FRANCK JAN
IPC: E04B1/10
Filed: 2015-04-28
Abstract: The invention relates to a method for producing a building as a timber-frame construction, frame construction, or post and beam construction, having a supporting framework consisting of pillars and/or struts, comprising the following steps: a) in the regions of subsequent pillars and/or struts of the timber-frame construction, frame construction, or post and beam construction plate-shaped wall building elements are provided with screws in such a way that the tips thereof protrude into the subsequent pillars and/or struts; b) behind the plate-shaped wall building elements shutterings for the supporting framework consisting of pillars and/or struts are produced from strips and/or insulating material; c) the shuttered regions for the framework are filled with a load-bearing, curable compound, in particular with concrete, wherein the hardening compound flows around the screws used in step a); d) after step a), at the latest after the curing of the compound, the plate-shaped wall elements are set up, fixed, and aligned; e) installation elements for electrical power, water, heating, etc. are mounted on the outer face of the plate-shaped wall building elements; f) plate-shaped wall building elements are fixed to the outer faces of the pillars and/or struts of the supporting timber-frame construction, frame construction, or post and beam structure; g) the remaining spaces between the plate-shaped wall building elements, the elements of the supporting framework, and/or the installation elements for electrical power, water, heating, etc. are filled with a bulk material or an insulating material. This allows for timber frame construction with planar walls.
Patent NZ-729514-A (NZ)
Title: Therapeutic multi-peptides t specific immune therapy for treatment of brain metastasis
Inventor: COSTANTINI DOMINIQUE
IPC: A61P35/04
Filed: 2014-11-06
Abstract: The present invention relates to a peptide vaccine composition OSE-2101 for treatment of brain metastasis in HLA-A2 positive patients, which comprises the peptides RLLQETELV (SEQ ID No 1), YLQLVFGIEV (SEQ ID No 2), LLTFWNPPV (SEQ ID No 3), KVFGSLAFV (SEQ ID No 4), KLBPVQLWV (SEQ ID No 5, with B indicating α-aminoisobutyric acid), SMPPPGTRV (SEQ ID No 6), IMIGHLVGV (SEQ ID No 7), KVAEIVHFL (SEQ ID No 8), YLSGADLNL (SEQ ID No 9), aKXVAAWTLKAAa (SEQ ID No 10, with X and a respectively indicating cyclohexylalanine and d-alanine).
Patent NZ-730799-A (NZ)
Title: Use of a long acting glp-1/glucagon receptor dual agonist for the treatment of non-alcoholic fatty liver disease
Inventor: HWANG SANG YOUN
IPC: A61K38/26
Filed: 2015-09-16
Abstract: The present invention relates to the use of a long-acting glucagon-like peptide-1 (GLP-1)/glucagon receptor dual agonist conjugate in a method for the prevention or treatment of liver inflammation in non-alcoholic fatty liver disease.
Patent PT-102388-A (PT)
Inventor: GIULIANI JOHN A
IPC: G06Q20/20
Filed: 1999-12-07
Abstract: A system, process and computer readable medium for distributing purchasing incentives throughout departments of a retail store including an incentive processor including a network controller and a database for storing shopping histories of consumers associated with respective unique consumer identifiers; a plurality of incentive distributors located throughout the departments of the retail store, each incentive distributor of the plurality of incentive distributors having a unique address, and including, a processor, a printing device, a network interface device, and one of a card reader device and a scanner device; and a network, coupling the network controller to network interface devices of the plurality of incentive distributors, for effecting two-way communications between the incentive processor and the plurality of incentive distributors. Each card reader device and each scanner device of the plurality of incentive distributors is configured to detect a card device passed therethrough or key tag device scanned therein, respectively. The card device and the key tag device having a unique consumer identifier encoded therein, and the unique consumer identifier is detected by a card reader or scanner device of a respective incentive distributor of the plurality of incentive distributors and transmitted via a network interface of the respective incentive distributor over the network to the network controller coupled to the incentive processor. The incentive processor is configured to generate the purchasing incentives based on a shopping history of a consumer associated with a detected unique consumer identifier received from the respective incentive distributor and a location of the respective incentive distributor determined from the unique address thereof.
Patent PT-103434-A (PT)
Title: Método e sistema para a inferência de haplotipos por parcimónia pura usando satisfação proposicional
Inventor: MARQUES SILVA JOAO PAULO DA
IPC: G06F17/30
Filed: 2006-02-13
Abstract: UMA DAS PRINCIPAIS LINHAS DE INVESTIGAÇÃO EM GENÉTICA CONSISTE EM DETERMINAR A RELAÇÃO ENTRE MUTAÇÕES E DOENÇAS GENÉTICAS, PARA O QUAL É NECESSÁRIO PROCEDER À ANÁLISE DO HAPLOTIPO. UM HAPLOTIPO É UMA SEQUÊNCIA DE ADN EM QUE ESTÃO IDENTIFICADAS AS MUTAÇÕES GENÉTICAS. EM ORGANISMOS DIPLÓIDES OS HAPLOTIPOS ORGANIZAM-SE AOS PARES, EM QUE UM HAPLOTIPO É HERDADO DO PAI E OUTRO DA MAE. NO ENTANTO, DEVIDO A LIMITAÇÕES TÉCNICAS, É HABITUALMENTE OBTIDO O GENOTIPO, O QUAL COMBINA A INFORMAÇÃO CONTIDA NUM PAR DE HAPLOTIPOS. LOGO, NÃO É POSSÍVEL DISTINGUIR QUE MUTAÇÕES FORAM HERDADAS DE CADA PROGENITOR. O PRESENTE INVENTO REFERE-SE A UM MÉTODO E UM SISTEMA PARA A INFERÊNCIA DE HAPLOTIPOS POR PARCIMÓNIA PURA USANDO SATISFAÇÃO PROPOSICIONAL. ESTE MÉTODO E ESTE SISTEMA, QUE SE INSEREM NA ÁREA DA BIOINFORMÁTICA, PERMITEM INFERIR HAPLOTIPOS A PARTIR DE GENOTIPOS DE MODO A QUE O NÚMERO DE HAPLOTIPOS UTILIZADO SEJA MÍNIMO.
Patent PT-108553-A (PT)
Title: Sistema de nivelação de uma grelha de enrelvamento ajustável
Inventor: CESAR AUGUSTO MOROUÇO GOMES
IPC: E02B11/00
Filed: 2015-06-12
Abstract: O OBJECTO DA PATENTE É UM SISTEMA DE NIVELAÇÃO DE UMA GRELHA DE ENRELVAMENTO AJUSTÁVEL (1) QUE SE CONECTA ENTRE OUTRAS REDES IGUAIS (FIG.2) ATRAVÉS DE PINOS CILINDRICOS MACHOS (4) QUE ENCAIXAM NOS RASGOS DE ENCAIXE (5) E DE UM PINO MACHO CILINDRICO DE ENGATE RÁPIDO COM UM ENGATE RÁPIDO FÊMEA. A AJUSTABILIDADE ENTRE GRELHAS, DEVIDO A IRREGULARIDADES DO PLANO DE ASSENTAMENTO OU GRANDES VARIAÇÕES TÉRMICAS, É DADO PELO EFEITO MOLA GERADO PELA INTERAÇÃO DE UM ESPESSURA FINA DA PAREDE (2) EM CONSONANCIA COM A ESPESSURA NORMAL DA PAREDE TRANSVERSAL DA GRELHA DE ENRELVAMENTO(3). A GRELHA POSSUI FUROS DE CONEXÃO (8) QUE POSSIBILITAM A SUA FIXAÇÃO EM QUALQUER PLANO. ESTE SISTEMA TEM CAPACIDADE DE DEFORMAÇÃO ENTRE AS SUAS JUNÇÕES, PERMITINDO ASSENTAR A GRELHA EM PISOS IRREGULARES, RESISTINDO A BAIXAS OU ALTAS TEMPERATURAS. POSSUI UM SISTEMA DE ACOPLAMENTO E POSICIONADOR QUE IMPEDEM A SUA DESMONTAGEM INVOLUNTÁRIA.
Patent RU-94018429-A (RU)
Inventor: VASIL EV A A
IPC: B29C65/18
Filed: 1994-05-20
Abstract: FIELD: welding of polymeric materials by hot tools. SUBSTANCE: heated roller holder has mechanism providing setting of roller in position where it is thermally insulated from surface of welded film. mechanism is made in form of flat system which has fixed crossmember used as support, two movable levers mounted on crossmember and connected to each other and furnished with pull-back spring, and carrier hinge-coupling roller holder, secured for turning on one of levers, with other lever. Crossmember has hole to provide contact of roller with welded film and travel limiter of one of levers to adjust roller-to-film pressure. EFFECT: enhanced convenience of operation and efficiency owing to cutting down of time required for brining roller out of contact with film at welding cycle intervals; provision of thermal insulation without the use of additional devices.
Patent RU-94020234-A (RU)
Inventor: JAKOVCHUK V V
IPC: A61F9/00
Filed: 1994-06-01
Abstract: FIELD: medicine; eye surgery. SUBSTANCE: method involves cutting out a surface scleral flap, separating the deeper scleral flap from the ciliary body and round ligament, and ablating this flap. A U-shaped plate fabricated from some memory shape material is placed between the surface scleral flap and the ciliary body so that the plate base is directed towards the scleral bed side wall. One distal end is attached to the inner surface of the scleral bed, and the other distal end having a pointed hook is placed at the surface of the inner wall of the ciliary canal so that the hook point is directed towards this wall. Sutures are applied, and the sclera temperature in the implant projection zone is reduced. EFFECT: higher efficacy.
Patent RU-94025034-A (RU)
Inventor: JANBEKOV K F
IPC: E01D15/127
Filed: 1994-07-04
Abstract: FIELD: metal bridge building, folding blocks of bridge spans. SUBSTANCE: bridge block able to be folded in crosswise and lengthwise directions includes two lower and two upper half-beams interconnected with lengthwise hinges with upper and lower plates of roadway with one placed over another. Roadway plates have hinges on their peculiar ends, and have slots on their other ends. Platform keels are inserted into the slots. The platform has guide trays. The trays are interacted with the rollers installed in cantilevers fastened to faces on lower corners of the half-beams. Side of the platform are folding-back. Blocks are installed on edges of folded side front part. External surfaces of folded sides have rotary secured struts. Besides, one transom of half-beams has eye-bolts, blocks, fork-type and single eyes, and worm gear. Another transom has axles with eyes of pins of two-way hydraulic shock absorbers. Lower parts of the transoms of the half- beams have semiautomatic butt joints, Ridge strips are fastened to transoms from upper zone. EFFECT: increased length of transported bridge block at the expense of lengthwise and crosswise unfolding sections directly on the platform of standard truck. 2 cl, 18 dwg
Patent RU-94026015-A (RU)
Inventor: MEL NIKOV A S
IPC: B63H11/08
Filed: 1994-07-13
Abstract: FIELD: shipbuilding; water-jet propellers for river and seagoing vessels and motor boats. SUBSTANCE: jet propeller has two loops to use energy of compressed air waste gases of engine-driven compressor. First loop is provided with jet nozzle and mixer in whose center elbowshaped air nozzle is mounted. Second loop has water and waste gas supply passages; jet nozzle with head is secured on end of this loop. Air supply passage is provided with nozzle assembly; passage feeding water to centrifugal pump is provided with damper which changes flow rate of water in turning the lever and shaft. EFFECT: increased reactive thrust; enhanced efficiency of propeller.
Patent RU-94026800-A (RU)
Inventor: IVANOV E I
IPC: C25D3/20
Filed: 1994-07-18
Abstract: FIELD: mechanical engineering and other relative industries and repair works, iron coatings precipitation. SUBSTANCE: iron-plating electrolyte has iron sulfate, aluminum sulfate and sulfuric acid and additionally has o-phenanthroline with following ratio of components: FeSO•7HO g/l, 420; Al(SO)•18HO g/l, 100; HSO, up to pH=2.5-3.0; o-phenanthroline, mole/l, 5•10-1•10. EFFECT: increased iron-plating precipitation speed.
Patent RU-94029172-A (RU)
Inventor: PCHELKIN L N
IPC: B23Q7/06
Filed: 1994-08-03
Abstract: FIELD: machine engineering, namely automatic machines with magazine-type charging of blanks for their piecewise delivering and reorientation at working process. SUBSTANCE: apparatus has a II-shaped bracket, whose one wall is in the form of a balancer with arms, kinematically joined with a rotation drive. A mechanism for piecewise delivery of parts is secured to one end wall of the bracket, a magazine for feeding parts is mounted on a gate valve, jaws are mounted on an opposite side of the bracket, having additional centering ducts for rods of the feeding magazine. A connecting wall of the bracket has a guide for preliminary orientation of the gate valve. A withdrawal chute has two portions, one of which is secured to a base and another - to the bracket. EFFECT: enhanced efficiency of the apparatus due to high reliability of blank basing. 1 cl
Patent RU-94035849-A (RU)
Inventor: VLASOV V I
IPC: C12P29/00
Filed: 1994-09-26
Abstract: FIELD: biotechnology, antibiotics. SUBSTANCE: culture Str. rimosus is grown on nutrient medium of the following composition, weight %: corn flour 13-15; soybean flour 0.7-0.9; chalk 1.4-1.6; corn extract 2.8-3.2, and propinol "Б"-400 0.01-0.02. After 156 h cultivation activity of cultural fluid is 14000 U/ml, antibiotic output from cultural fluid is 39 billion U, efficiency is. After 206 h growth activity, output, efficiency are 18300 U/ml, 52 billion U and, respectively. EFFECT: increased yield of oxytetracycline.
Patent RU-94039352-A (RU)
Inventor: GORJAJNOV G E
IPC: F16L57/00
Filed: 1994-10-18
Abstract: FIELD: pipe line transport. SUBSTANCE: method comprises strengthening pipe members of a pipe line by use of twisting spirals made of metallic shapes, e. g. disk or narrow strip, whose ultimate strength is higher than that of the pipe line. The spiral the inner diameter of which is less than the outer diameter of a pipe is preliminary heated up to a temperature 100-350°C and then is pressed on and welded to the pipe. EFFECT: simplified method. 1 dwg
Patent RU-94044798-A (RU)
Inventor: BORDAKOV V N
IPC: A62C2/00
Filed: 1994-12-21
Abstract: FIELD: fire extinguishing. SUBSTANCE: invention relates to blanking fires by agency of fire-blanking gas/air sols and may be applied in complex engineering systems, flow, partially closed, and closed spaces in airborne technics, sea fleet, transport, etc. Spatial fire blanking is effected by way of burning solid charge to form fire-extinguishing gas/air sol mixture, which is delivered and spread in the space to be protected, prior to be delivered the mixture having been effectively cooled in contact with solid-phase cooler based on salt crystalline hydrates. As a rule, mixture, when cooled, is simultaneously saturated with flame inhibitors. Arrangement for spatial fire blanking includes solid-charge combustion chamber, igniter, nozzle, and aforementioned solid-phase cooler mounted in the chamber free to interact with solid charge combustion products. Cooler consists of mechanical mixture of metal salt crystalline hydrates, ultra-disperse powders of hydrocarbon flame inhibitors, and inert binder. EFFECT: provided controlling average-space temperature of air sol generating composition combustion products in spatial flame blanking, including that in closed spaces, with simultaneously using high-efficiency hydrocarbon flame inhibitors.
Patent RU-94045327-A (RU)
Inventor: GOLOVKOV A A
IPC: H04B7/22
Filed: 1994-12-27
Abstract: FIELD: radio communication, radio engineering. SUBSTANCE: invention refers to field of radio communication and may be used to organize communication between three subscribers of which one has no transceiving station in traditional sense but is located in close vicinity of controlled artificial inhomogeneity. Transceiving station emits basic carrier signal at frequency F1 which amplitude is modulated with basic information signal with frequency of first subscriber. Carrier signal is received with the aid of formed artificial inhomogeneity, basic information signal is isolated from it and fixed with the use of earphone, for example, and additional carrier signal is formed on second harmonic of basic carrier signal. Additional information signal with frequency of second subscriber located close to inhomogeneity is formed with the help of microphone, for instance, and is used to act on formation of artificial inhomogeneity. Additional carrier signal is reflected and basic and additional information signals are extracted from it by means of transceiving station. EFFECT: increased security and volume of information exchange between three subscribers.