Patent SG-11201906616V-A (SG)
Title: Nasal pharmaceutical compositions for reducing the risks of exposure to air pollutants
Inventor: MATTERN CLAUDIA
IPC: A61K9/06
Filed: 2018-01-19
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 July 2018 (26.07.2018) WIPO I PCT 0111111010 0111 °nolo o1111 mil niou oimIE (10) International Publication Number WO 2018/134783 Al (2017.01) (2006.01) (2006.01) (2006.01) (51) International Patent Classification: A61K 33/00 (2006.01) A61K 47/44 A61K 9/00 (2006.01) A61P 39/00 A61K 47/02 (2006.01) A61P 37/08 A61K 47/14 (2017.01) A61P 29/00 A61K 9/06 (2006.01) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (21) International Application Number: PCT/IB2018/050349 (22) International Filing Date: 19 January 2018 (19.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/448,556 20 January 2017 (20.01.2017) US 62/517,369 09 June 2017 (09.06.2017) US (71) Applicant: M ET P PHARMA AG [CH/CH]; Schynweg 7, P.O. Box 138, 6376 Emmetten (CH). (72) Inventor: MATTERN, Claudia; c/o M et P Pharma AG, Schynweg 7, P.O. Box 138, 6376 Emmetten (CH). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, Published: — with international search report (Art. 21(3)) — in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE (54) Title: NASAL PHARMACEUTICAL COMPOSITIONS FOR REDUCING THE RISKS OF EXPOSURE TO AIR POLLUTAN- TS (57) : Described herein are methods for reducing the risks of exposure to air pollutants, comprising nasally administering to a subject in need thereof a composition that counteracts the effects of one or more air pollutants, wherein the composition is adapted for nasal administration. In some embodiments the composition comprisees an agent that binds to one or more air pollu- tants, wherein the agent comprises one or both of nonporous silicon dioxide and porous silicon dioxide and/or the composition provides a physical barrier between one or more air pollutants and internal nasal surfaces. Also described herein are nasal compositions comprising an agent com- prising one or both of nonporous silicon dioxide and porous silicon dioxide, a lipophilic or partly lipophilic vehicle, and a surfactant, wherein the composition is adapted for nasal administration. Also described herein are methods of making and using nasal pharmaceutical compositions. W O 20 18/ 13 47 83 Al FIG. 10B