baber/WOPTO huggingface dataset:
Patent PT-1291352-E (PT)
Inventor: CHU DANIEL T
IPC: A61K31/70
Filed: 1997-09-02
Abstract: 6-Substituted ketolides of e.g. formula (II) or (III), and their salts, esters and prodrugs are new: Y + Z = X; X = OH, =NOR1 or =NOC(R5)(R6)OR1; or one of Y and Z = H; and the other = H, OH, protected OH or NR7R8; R1 = 1-12C alkyl (optionally substituted), 3-12C cycloalkyl or SiR2R3R4; R2-R4 = 1-12C alkyl or aryl; R5, R6 = H or 1-12C alkyl (optionally substituted), or R5 + R6 = 3-12C cycloalkyl; R7, R8 = H or 1-6C alkyl; or NR7R8 = 3-7 membered ring which, when the ring is 5-7 membered may optionally contain O, NH, N(1-6C alkyl), N(aryl), N(aryl-1-6C alkyl), N (substituted aryl-1-6C alkyl), N(heteroaryl), N(heteroaryl-1-6C alkyl), N(substituted heteroaryl-1-6C alkyl), S or S(O)n; n = 1 or 2; Ra = H or OH; Rc = H or hydroxy protecting group; R9 = 1-6C alkyl (optionally substituted), 3-7C cycloalkyl or optionally substituted aryl or heteroaryl; M = CONH, NHCO, NH, N=, NMe, NHCOO, NHCONH, OCONHY, OCOO, O, S(O)n, COO, OCO or CO; R = methyl (substituted by CN, F, CO2R10, S(O)nR10, NHCOR10, NHCONR11R12, aryl, substituted aryl, heteroaryl or substituted heteroaryl); 2-10C alkyl (optionally substituted), 3C alkenyl (substituted by halo, CHO, CO2R10, COR9, CONR11R12, CN, optionally substituted aryl or heteroaryl, 3-7C cycloalkyl or 1-12C alkyl substituted by heteroaryl); 4-10C alkenyl (optionally substituted), or 3-10C alkynyl optionally substituted); R10 = 1-3C alkyl (optionally aryl substituted), or heteroaryl substituted 1-3C alkyl; R11, R12 = H or 1-3C alkyl (optionally substituted); A, B, D, E = H, 1-6C alkyl (optionally substituted by optionally substituted), 3-7C cycloalkyl, optionally substituted aryl or heteroaryl, heterocycloalkyl or 1-6C alkyl substituted by MR9; provided that \- 2 of A, B, D and E = H; or any one pair of substituents, consisting of AB, AD, AE, BD, BE or DE taken with the atoms to which they are attached, form a 3- to 7-membered ring optionally containing O, NH, N(1-6C alkyl), N(aryl-1-6C alkyl), N(substituted aryl-1-6C alkyl), N(heteroaryl-1-6C alkyl), N(substituted heteroaryl-1-6C alkyl), S, S(O)n, CONH, CONR12, NHCO, NR12CO or C(=NH)NH.
Patent PT-1390007-E (PT)
Title: Cosmetic composition based on zinc and copper sulphates and sucralphate
Inventor: FABRE PIERRE
IPC: A61K33/34
Filed: 2002-05-07
Abstract: The invention relates to a cosmetic composition comprising an association of sucralphate and a mixture of zinc and copper sulphates in an excipient suitable for topical application to the skin. More specifically, said composition is intended for the regenerating, healing and/or anti-inflammatory treatment of the skin.
Patent PT-1392377-E (PT)
Title: Medication injector apparatus with drive assembly that facilitates reset
Inventor: ATTERBURY WILLIAM GODWIN
IPC: A61M5/24
Filed: 2002-05-08
Abstract: A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The injection pen includes a doseable quantity identifier that uses a rotational matrix (500) and a sensor (502) for electrically sensing the arrangement of the dose setting mechanism of the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting.
Patent PT-1428870-E (PT)
Title: Reduction in the virulence of mycobacterium tuberculosis and protection against tuberculosis by means of phop gene inactivation
Inventor: MONTANES CARLOS MARTIN
IPC: C07K14/35
Filed: 2002-07-30
Abstract: The construction of a mutant in the phoP gene by means of homologous recombination from clinically isolated Mycobacterium tuberculosis reduces the virulence thereof in mouse bone marrow macrophage. Moreover, the phoP mutant reduces the virulence thereof in the experimental mouse model. Said phoP mutant can persist without being eliminated both in the macrophage and in the mouse. Mice inoculated with the phoP mutant are protected against M.tuberculosis infection. The use of mutants of mycobacteria in which the phoP gene or the genes regulated by phoP have been inactivated are candidates for vaccines against human and animal tuberculosis as well as possible recombinant vaccines against other pathogens.
Patent PT-1417175-E (PT)
Title: Substituted dihydro 3-halo-1h-pyrazole-5-carboxylates, their preparation and use
Inventor: LAHM GEORGE PHILIP
IPC: C07D413/04
Filed: 2002-08-13
Abstract: This invention relates to a compound of Formula I, a method for its preparation and its use in the preparation of a compound of Formula II wherein R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, X and n are as defined in the disclosure. This invention also discloses preparation of compounds of Formula III wherein R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>6</SUP>, R<SUP>7</SUP>, R<SUP>8 </SUP>and n are as defined in the disclosure. Also disclosed are certain intermediates of Formula 4 for the preparation of compounds of Formula I wherein X is N and R<SUP>2</SUP>, R<SUP>3 </SUP>and n are as defined in the disclosure.
Patent PT-1423062-E (PT)
Title: Rehabilitative shoe insole device
Inventor: GARDINER ROY
IPC: A43B17/00
Filed: 2002-08-26
Abstract: An insole device configured to fit the profile of the human foot to promote proprioceptive stimulation of the Golgi tendon organ. The midfoot section of the insole device has an asymmetric domed structure that is presented to the plantar aspect of the foot at a location found to be the anatomical apex of the foot's arch system. The asymmetric domed structure displays physical properties to catalyst muscle group balancing by using the body's proprioceptive feedback mechanisms. The asymmetric domed structure displays physical properties such that it does not provide functional bracing or support to the plantar aspect of the foot. The net result will be more structurally sound foot capable of more energy efficient and less injury inducing use. The plantar aspect of the insole or midsole device is characterized by a dominant cavity having the ability to receive and interchange the biofeedback catalyst and the many forms therefore, as well as being characterized by provisions to ensure proper and permanent placement of the catalyst.
Patent PT-1350909-E (PT)
Inventor: PRUNBAUER KURT
IPC: E05B27/00
Filed: 2003-03-24
Abstract: Key for a cylinder lock has a key shaft (3) with at least three control grooves (4-6) running primarily along the shaft insertion direction so that they also intersect in a number of points. One of the grooves (6) is deeper than the remaining three. The key shaft is essentially cylindrical and the grooves are cut into it.  The invention also relates to a corresponding cylinder lock.
Patent PT-1376288-E (PT)
Title: Differential pressure electromagnetic valve
IPC: F16K31/40
Filed: 2003-02-20
Abstract: A differential pressure electromagnetic valve that comprises a valve body (1), said valve body (1) comprising an upper part (11) and a lower part (12), a membrane (2) which divides the interior of the valve body (1) into a first pressure chamber (R1) and a second pressure chamber (R2), a valve rocker (3) joined to the membrane (2), and a magnetic valve (4) that controls the pressure difference between the first pressure chamber (R1) and the second pressure chamber (R2). The lower part (12) has a gas input port (121) and a gas output port (122) that are linked to the first pressure chamber (R1), said gas output port (122) being opened and closed directly by means of the valve rocker (3). The magnetic valve (4) is placed on one side of the upper part (11) of the valve body (1). <IMAGE>
Patent PT-1384581-E (PT)
Title: Printing device for scored cardboard sheets
Inventor: GOMEZ ANGEL CASADO
IPC: B41F17/24
Filed: 2003-07-24
Abstract: Of the type of constituents with a base or mylar (7) constituting the support for a printing plate (8), between these elements supplements (12' - 13) are established, which produce linear protuberances (11) on the working surface of the plate (8). These are longitudinal and cross-sectional in correlation with the lines or scores created by the corrugator machine for the fragmentation of the continuous strip of cardboard. The linear protuberances (11) penetrate the scores of the cardboard resulting in a quality printing over the whole of the surface of the cardboard, in both the relatively flat and more sunken areas. The supplements (12' - 13) between the base (7) and plate (8) may also be established in the centre of the plate, more specifically establishing these complementary supplements (14) and (15) also in correlation with the linear protuberances (11) on the working surface of the plate (8). <IMAGE>
Patent PT-1698231-E (PT)
Title: Cream cheese product and its method of preparation
Inventor: HABERMEIER PETER
IPC: A23C21/06
Filed: 2004-11-25
Abstract: The invention relates to a cream cheese product obtainable by a process comprising the steps of:  (a)  acidifying a whey protein concentrate with a food grade acidulant or with starter bacteria to reduce the pH to more than 4.5 to about 5.2,  (b)  heating the acidified whey protein concentrate of step (a) slowly to a temperature of about 75° to about 90°C and maintaining it for at least about 30 min to produce a functional whey protein concentrate,  (c)  optionally blending the whey protein concentrate of step (b) with milk fat in a weight ratio of about 60:40 to about 100:0 wherein step (c) may be carried out before step (b),  (d)  homogenizing the blend obtained in step (b) or (c) in a 2-stage high-pressure homogenizer at pressures of about 300-400/50-80 bar and a temperature of about 5° to about 75°C to produce an emulsified functional whey protein concentrate,  (e)  blending the product of step (d) with curd the fat content of which is adjusted in accordance with the milk fat portion added in step (c) and with the desired product, and adding salt and optional stabilizers, and  (f)  homogenizing the product of step (e) in a 2-stage high-pressure homogenizer at pressures of about 300-400/50-80 bar and at a temperature of about 68° to about 90°C.
Patent PT-1737962-E (PT)
Title: Gas1 universal leader
Inventor: WILDT RUDOLPH M T DE
IPC: C12N15/10
Filed: 2005-03-24
Abstract: Disclosed is a method of producing an immunoglobulin heavy chain variable domain polypeptide comprising: culturing a host cell which has been transformed with a polynucleotide molecule encoding said immunoglobulin heavy chain variable domain polypeptide under conditions to express said immunoglobulin heavy chain variable domain polypeptide wherein said polynucleotide molecule comprises a nucleic acid encoding a GAS1 secretion signal peptide operably linked to the immunoglobulin heavy chain variable domain polypeptide.
Patent PT-1954710-E (PT)
Title: Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides
Inventor: TIAN FENG
IPC: A61K47/48
Filed: 2006-11-08
Abstract: Disclosed herein are accelerants for the formation of oxime-containing compounds from the reaction of a carbonyl-containing compound and a hydroxylamine-containing compound. The oxime-containing compound, the carbonyl-containing compound and the hydroxylamine-containing compound can each be a non-natural amino acid or a non-natural amino acid polypeptide. Also disclosed is the use of such accelerants to form oxime-containing compounds, the resulting oxime-containing compounds, and reaction mixtures containing such accelerants.
Patent PT-1837367-E (PT)
Title: Magnesium hydroxide, its use and process for the preparation of resins equipped therewith
Inventor: KATSUKI KEIKO
IPC: C08L101/00
Filed: 1996-12-13
Abstract: A flame retardant having heat deterioration resistance which is composed of magnesium hydroxide particles having 
(i) an average secondary particle diameter, measured by a laser diffraction scattering method, of not more than 2 µm, 
(ii) a specific surface area, measured by a BET method, of not more than 20 m 2 /g, and containing (iii) a total amount of iron compound and manganese compound of not more than 0.02 % by weight in terms of metals, and a synthetic resin composition comprising the same and a molded article therefrom.
Patent PT-2057984-E (PT)
Title: Retard tablets with hydromorphon
Inventor: ZINGRAFF MARC
IPC: A61K9/16
Filed: 2007-11-09
Abstract: Tablet comprises a tablet core made of several active agents containing pellet and one or more auxiliary materials, where: at least a coating is applied on the tablet core; and the pellet contains an active agent of hydromorphone or its salts and/or solvate, and exhibits the following structure: an inert core, an active agent layer applied on the inert core, a layer applied on the active agent layer, which retards the release of active agent, and a further layer applied on the layer retarding the release of active agent. An independent claim is included for the active agent containing pellets with hydromorphone.
Patent PT-2089030-E (PT)
Title: Agent for prophylaxis or treatment of alcohol dependence or drug dependence
Inventor: TESHIMA KOJI
IPC: A61K31/454
Filed: 2007-10-16
Abstract: The present invention provides an agent for the prophylaxis or treatment of substance abuse and dependence, which contains a compound of the formula (I) represented by (R)-2-{3-[1-(acenaphthen-1-yl)piperidin-4-yl]-2,3-dihydro-2-oxo-benzimidazol-1-yl}-N-methylacetamide, or a pharmaceutically acceptable salt thereof as an active ingredient.
Patent PT-2088259-E (PT)
Title: Device for pre-tensioning reinforcement elements on structures
Inventor: SCHERER JOSEF
IPC: E01D22/00
Filed: 2009-01-23
Abstract: The method involves producing pre-tensioning between a building and a clamping shoe (1) attached at a reinforcement laminate-end by using a hydraulic cylinder-piston unit (9) that is utilized in a device for tensioning. Pre-tensioning is maintained by driving a set-screw between a tensioning device and the clamping shoe. The piston unit is removed under retention of the pre-tensioning held by the screw. The tensioning device and the shoe are removed from a building after hardening of an adhesive. The shoe is provided for clamping of the laminate-ends and a box-type metal body (3). An independent claim is also included for a device for pre-tensioning of reinforcement laminates at a building.
Patent PT-641505-E (PT)
Inventor: MALEK CHARLES JOHN
IPC: H04W12/00
Filed: 1993-05-11
Abstract: In a wireless communication system comprising a plurality of fixed communication units (FCUs) (102) and portable communication units (PCUs) (120), each comprising an encryption synchronization counter (ESC) (314, 414), the PCU and FCU having a digital transmission format (201), a method of maintaining encryption and decryption throughout a hand-off is shown, comprising the steps of: (a) loading (708) during a hand-off initiation a continuation value for a second FCU ESC; and (b) incrementing (709) synchronously the second FCU ESC and the PCU ESC, starting from the continuation value and beginning at the time of hand-off completion.
Patent PT-650482-E (PT)
Inventor: WOOD WILLIAM WAKEFIELD
IPC: C07D239/56
Filed: 1993-07-15
Abstract: PCT No. PCT/EP93/01880 Sec. 371 Date Jul. 24, 1995 Sec. 102(e) Date Jul. 24, 1995 PCT Filed Jul. 15, 1993 PCT Pub. No. WO94/02470 PCT Pub. Date Feb. 3, 1994   <IMAGE>  (I)  Compounds of formula (I) in which X1 and X2 each represents oxygen; S(O)n, n being 0, 1 or 2; or CO, CH2 or NR, R being hydrogen or alkyl; R1 and R10 are each hydrogen or halogen; R2 and R9 are each hydrogen, halogen, cyano, nitro, alkyl, halo-alkyl, alkoxy, alkylthio, amino, mono- or di-alkylamino, alkoxyalkyl, haloalkoxyalkyl or alkoxycarbonyl; R3 and R8 are each hydrogen, chlorine, alkyl, haloalkyl, haloalkenyl, halo-alkynyl, haloalkoxy, haloalkoxycarbenyl, haloalkylthio, haloalkoxyalkyl, haloalkylsulphinyl, or haloalkylsulphonyl, nitro or cyano; R4 and R7 are each hydrogen, halogen, alkyl or alkoxy; R5 is hydrogen, halogen, cyano, alkyl, haloalkyl, alkoxy, alkylthio, alkylsulphonyl or phenyl; and R6 is hydrogen or, when R5 is hydrogen, alkyl; provided that either each phenyl is unsubstituted or at least one of R3 and R8 is not hydrogen, have useful pesticidal activity.
Patent PT-827697-E (PT)
Inventor: PAHUD JEAN-JACQUES
IPC: A23L33/18
Filed: 1996-09-06
Abstract: Use of whey, that has been 15-20% hydrolysed enzymatically, for preparation of compositions that induce oral tolerance to cows' milk in susceptible mammals, is new. The whey has a level of immunological detection of allergenic proteins ≥ 100 times less than that of unhydrolysed whey.
Patent PT-735369-E (PT)
Inventor: KISER ERNEST J
IPC: C12Q1/26
Filed: 1996-03-26
Abstract: A chemical timer for a direct-reading reagent test strip changes color a predetermined time after a biological fluid is applied to the strip. The strip measures the concentration of an analyte in the fluid. The timer is a dry coating of an indicator, a reagent that when hydrated can react with glucose to change the color of the indicator, an inhibitor to inhibit the change in color of the indicator, and glucose. Preferably, the reagent and glucose are present in excess in the coating, and the time it takes for the timer color to change can be controlled by the inhibitor concentration.
Patent PT-809468-E (PT)
Inventor: CARLS THOMAS A
IPC: A61F2/46
Filed: 1996-02-15
Abstract: A cutting guide for resecting a patient's proximal tibia to receive a tibial prosthesis is disclosed. The cutting guide comprises an instrument body (76) and mounting means for attaching the cutting guide to a rod (21) that tracks the patient's intramedullary canal (12) which enables the surgeon to reference surgical cuts with respect to the patient's intramedullary canal. The cutting guide also comprises a cutting element (78) for being driven longitudinally into the proximal tibia during use, and at least one cutting guide surface (90, 91) for guiding a saw instrument of the surgeon.
Patent PT-854751-E (PT)
Inventor: PLINKE MARC
IPC: D04H1/58
Filed: 1996-06-07
Abstract: The present invention is an improved catalytic filter material for use in removing contaminants such as NOx from a fluid stream. The filter of the present invention employs composite fibers of expanded polytetrafluoroethylene (PTFE) filled with catalytic particles. The composite fibers are chopped into staple fibers and made into a felt material. Preferably, the felt material is then laminated on at least one side with a protective microporous membrane. The combined filter removes both macro-particles, such as dust, from the filter stream before the dust can clog active catalytic sites and effectively catalytically coverts undesirable contaminants in the fluid stream to acceptable end products.
Patent PT-854770-E (PT)
Inventor: GAETA ANTHONY C
IPC: B24D3/34
Filed: 1996-07-16
Abstract: A washable coated abrasive material comprising a substrate and maker, size and optionally supersize coats and a functionalized polysiloxane modifying the binder of the outermost layer.
Patent PT-876388-E (PT)
Inventor: SPINA KENNETH P
IPC: C07H17/08
Filed: 1996-10-17
Abstract: Compounds, or pharmaceutically acceptable salts and esters thereof, of formulae (I); (II); (III) or (IV) wherein A, B, D and E, R<1>, R<2> and Z are specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of antibacterial infections with such compositions, and processes for the preparation of the compounds.
Patent PT-1084771-E (PT)
Inventor: GARCIA FRANCISCO JAVIER SANCHE
IPC: A47L11/38
Filed: 1998-04-16
Abstract: Machine intended to dose and apply chemical products to vertical walls, such chemical products being for example water, soap, detergent, pickling agents, enamels, paints, primers, waterproofers, polishers, bactericides, combinations of the same and other chemical, biological products having functions such as cleaning, protection, preparation and/or decoration of faades, said products being then processed by means of a roller in order to clean, wash, brush, sand, polish, enamel, etc. and finally dry the treated surface. The machine applies the above mentioned products and other products having similar characteristics, process them by means of various accessories and finally dries them; all these operations are automated.  <IMAGE>
Patent PT-992014-E (PT)
Inventor: WILSON DONALD W
IPC: G06Q40/00
Filed: 1998-06-29
Abstract: In a device and method to provide a gateway for the transfer of information between financial markets and customers, a processor is coupled to a customer system and to a financial market system. The processor receives transaction information from the customer system in a first format, converts it to a second format and transmits the transaction information to the financial market system. The processor receives an acknowledgment and a transaction confirmation from the financial market system in the second format, converts these to the first format and transmits the acknowledgment and the transaction confirmation to the customer system. The processor may also be coupled to a memory, where it stores tracking information relating to the transaction information, the acknowledgment and/or the transaction confirmation.
Patent PT-961894-E (PT)
Inventor: SIMOENS HERVE
IPC: F16K31/40
Filed: 1998-12-17
Abstract: A monostable valve for controlling the sudden discharge of a gas contained in an enclosure. This valve comprises, in a control conduit (17), a second shutoff (18) between a closed position wherein the gas contained in the control chamber (13) cannot escape and a discharge position wherein the gas contained in the control chamber can escape, a drive mechanism (19) for rapidly moving the control shutoff to its discharge position, and a mechanism (20) for returning the control shutter to its closed position, respectively, and in that the area defined by the cross section of the discharge conduit (11) is at least constant, even increasing from the rear chamber (9) toward the outlet conduit (6) in order to limit head loss, and the main shutter (12) has low inertia.