baber/WOPTO huggingface dataset:
Patent DE-60325719-D1 (DE)
Inventor: OAKLEY ROBERT H
IPC: G01N33/15
Filed: 2003-05-12
Granted: 2009-02-26
Abstract: The present invention relates to agonist-independent methods of screening for compounds that alter GPCR desensitization. Included in the present invention are cell lines containing GRKs, in which GPCRs are desensitized in the absence of agonist; the GRKs may be modified. The present invention relates to methods to determine if a GPCR is expressed at the plasma membrane, and if the GPCR has an affinity for arrestin. Modified GPCRs which have increased arrestin affinity are included in the present invention. These modified GPCRs are useful in methods to screen for compounds that alter desensitization, including both the agonist-independent methods and agonist-dependent methods described herein.
Patent DE-60326957-D1 (DE)
Inventor: BARTH MARTINE
IPC: C07D409/12
Filed: 2003-06-12
Granted: 2009-05-14
Abstract: N-((N-(4-Amidinobenzyl)-N-methylcarbamoyl)-alkyl)-arylsulfonamides (I) are new.  Aryl sulfonamide derivatives of formula (I) and their acid addition salts are new. R1  =  aromatic nucleus (optionally substituted by one or more of halo, 1-3C alkyl, 1-3C alkoxy, NO2, CN, CF3 or OCF3);  R2  =  H or 1-4C alkyl (optionally substituted by phenyl, CONH2 or one or more F);  R3  =  H or OH;  R4  =  H;  or R3 + R4  =  -CH=N- or 2-4C alkylene;  R5  =  H or 1-3C alkyl;  R6  =  H or halo;  Y  =  optionally unsaturated 2-4C alkylene (optionally interrupted by O).  An Independent claim is included for the preparation of (I).
Patent DE-60327514-D1 (DE)
Inventor: FEBBRORIELLO PETER
IPC: A61B13/00
Filed: 2003-01-22
Granted: 2009-06-18
Abstract: Systems and methods for observing and recording retinal irregularities are disclosed. A method according to the invention includes illuminating a viewing area with a steady light, illuminating the viewing area with a flash pattern, and enabling a user to observe, by looking at the illuminated viewing area, a visual representation of the existence of a retinal irregularity. The viewing area is illuminated with the steady light and flash pattern such that the user can identify in the viewing area a visual abnormality that is indicative of the retinal irregularity. The user can provide a description of the visual representation, which can be forwarded to a caregiver for analysis.
Patent DE-60330263-D1 (DE)
Inventor: PRYDZ HANS PETER B
IPC: A61K48/00
Filed: 2003-02-06
Granted: 2010-01-07
Abstract: The present invention relates to synthesised RNAs, more specific short interfering RNAs (siRNAs) that are able to modulate the expression of Tissue Factor (TF), as well as to a pharmaceutical preparation comprising the synthesised siRNA(s) and use thereof.
Patent DE-60330896-D1 (DE)
Inventor: GORDON ROY G
IPC: C23C16/455
Filed: 2003-11-14
Granted: 2010-02-25
Abstract: Metal films are deposited with uniform thickness and excellent step coverage. Copper metal films were deposited on heated substrates by the reaction of alternating doses of copper(I) NN'-diisopropylacetamidinate vapor and hydrogen gas. Cobalt metal films were deposited on heated substrates by the reaction of alternating doses of cobalt(II) bis(N,N'-diisopropylacetamidinate) vapor and hydrogen gas. Nitrides and oxides of these metals can be formed by replacing the hydrogen with ammonia or water vapor, respectively. The films have very uniform thickness and excellent step coverage in narrow holes. Suitable applications include electrical interconnects in microelectronics and magnetoresistant layers in magnetic information storage devices.
Patent DE-60332722-D1 (DE)
Inventor: BOL JEAN LOUIS
IPC: B65B55/16
Filed: 2003-07-30
Granted: 2010-07-08
Abstract: The present invention is related to an apparatus and method for irradiating a product package, comprising a radiation source directing a radiation beam along a beam direction towards said product package, conveying means for transporting said product package past said radiation source along a transport path, and reflecting means located on at least one side of the plane formed by said beam direction and said transport path. By adjusting the distance and angle of the reflecting means to the conveyor and beam, and improved dose uniformity ratio is obtained. <IMAGE>
Patent DE-60332871-D1 (DE)
Inventor: JANZIG DARREN A
IPC: A61N1/36
Filed: 2003-12-09
Granted: 2010-07-15
Abstract: In an implantable medical device having individual modules, a coupling module couples the modules to one another. The coupling module supports electrical and/or mechanical coupling of the modules. The coupling module may assume a variety of shapes or configurations. The various embodiments of the coupling module may offer the modules varying degrees of freedom of movement relative to one another.
Patent DE-60332972-D1 (DE)
Inventor: SKOG ROBERT
IPC: H04M1/7243
Filed: 2003-12-30
Granted: 2010-07-22
Abstract: A method, a system, a server, and a computer program product are provided for Multimedia Capability discovery of different user terminals. Unnecessary use of the radio interface is avoided based on a network storage, which is accessible without registration to find out about the calling as well as the called user's multimedia capabilities during a voice call. If there is a positive capability discovery result out of this for both users, the system sends a message to each of the user terminals that they should notify the users, e.g., by displaying an icon above a soft button. There is no need for establishing a packet switched session, which uses a lot of radio interface signalling, until the Multimedia Service capability of both subscribers and their user terminals is investigated and responded to both user terminals and their users.
Patent DE-60333436-D1 (DE)
Inventor: LANNI THOMAS W
IPC: G05F1/46
Filed: 2003-12-05
Granted: 2010-09-02
Abstract: A power supply system includes an adapter to receive power from a power source, and output a regulated output voltage (Vout). A tip receives Vout from the adapter, and output Vout to an electronic device. The tip includes active circuitry to adjust a programming voltage (Vprog). Vprog is fed back to the adapter to control a magnitude of Vout. <IMAGE>
Patent DE-60335225-D1 (DE)
Inventor: AVAR ERIC P
IPC: A43B13/26
Filed: 2003-12-10
Granted: 2011-01-13
Abstract: An article of footwear is disclosed that includes upper (20) and a sole structure (30). The upper defines an interior void that is configured to receive the sole structure and a foot. A lower surface of the upper defines a plurality of apertures (24a-24f), and the sole structure includes a plurality of projections (32a-32f) that extend through the apertures to form a ground-engaging surface. The projections are connected to a foot-supporting member (31) that remains within the upper. A locking system (25, 37, 35a-35f) is incorporated into the upper and sole structure to secure the sole structure to the upper.
Patent DE-68901153-D1 (DE)
Inventor: LINDBORG BJOERN GUNNAR
IPC: C07D473/32
Filed: 1989-05-05
Granted: 1992-05-14
Abstract: Antivirally active compounds of the formula <CHEM>  wherein:  R<1> is hydrogen, hydroxy, mercapto or amino;  R<2> is hydrogen, hydroxy, fluoro, chloro or amino;  R<3> and R<4> are independently selected from   - @(OM)2, <CHEM>  amino, hydroxy  or an ether or ester residue thereof, or  R<3> together with R<4> is <CHEM>  wherein M is hydrogen or a pharmaceutically acceptable counterion; and n is 1 or 2; with the proviso that, when R<2> is amino and R<3> and R<4> are hydroxy, R<1> is not hydroxy and in addition, when n = 1, R<1> is not hydrogen, and pharmaceutically acceptable salts thereof; processes and preparation of said compounds, a pharmaceutical composition comprising said compounds, methods for treatment of virus infections as well as use of compounds of the formula I without the proviso for the manufacture of a medicament for treatment of AIDS.
Patent DE-68905610-D1 (DE)
Inventor: KEYS DALEN EUGENE
IPC: G03F7/027
Filed: 1989-01-12
Granted: 1993-05-06
Abstract: An improved process is disclosed for the preparation of reflection holograms in said photopolymerizable layers. The reflection hologram may be enhanced by treatment with certain enhancing agents, or by heat treatment.
Patent DE-68926816-D1 (DE)
Inventor: HOUSEY GERARD M
IPC: C12Q1/00
Filed: 1989-02-09
Granted: 1996-08-14
Abstract: Method of determining whether a substance is an inhibitor or activator of a protein whose prodn. by a cell evokes a responsive change in a phenotypic characteristic other than the level of the protein in the cell per se is claimed, which comprises (a) providing a first cell line (CLI) which produces the protein and exhibits the phenotypic response to the protein, (b) providing a second cell line (CLII) which produces the protein at a lower level than CLI or does not produce the protein at all and which exhibits the phenotypic response to the protein to a lesser degree or not at all, (c) incubating the substance with CLI and CLII and (d) comparing the phenotypic response of the CLI to the substance with the phenotypic response of the CLII to the substance. - Phenotypic changes which may be observed and compared are e.g. ability of the cells to grow in an anchorage-independent manner, to grow in soft agar, to form foci in cell culture and to take up selected strains.
Patent DE-68929334-D1 (DE)
Inventor: WAINWRIGHT NORMAN R
IPC: G01N27/02
Filed: 1989-06-21
Granted: 2001-11-22
Abstract: Endotoxin binding proteins capable of binding endotoxin in vivo, which are isolated from a horseshoe crab such as Limulus polyphemus, pharmaceutical compositions and pharmaceutical uses of the proteins, a method of purifying the proteins and an assay for endotoxin based on the proteins, are disclosed. <IMAGE>
Patent DE-69002068-D1 (DE)
Inventor: FINARDI IVO
IPC: E05B65/08
Filed: 1990-01-12
Granted: 1993-08-05
Abstract: The present invention relates to a manually and automatically operated lock in particular for rolling gates, comprising, inside a holding body (1), an electric motor (2) which, through a gear train (3), drives a pair of side rods (4). The lock further comprises a key cylinder which cooperates with an intermediate element of the gear train (3) to disengage, under the control of a key, the kinematic coupling with the motor (2), while holding the kinematic coupling with the side rods (4).
Patent DE-69002322-D1 (DE)
Inventor: FENET EMERIC GUY
IPC: A61M5/50
Filed: 1990-01-05
Granted: 1993-08-26
Abstract: PCT No. PCT/FR90/00007 Sec. 371 Date Jun. 18, 1991 Sec. 102(e) Date Jun. 18, 1991 PCT Filed Jan. 5, 1990 PCT Pub. No. WO90/07949 PCT Pub. Date Jul. 26, 1990.A single use disposable syringe having a piston axially slidable in a barrel for undergoing a retraction movement to fill the barrel with fluid and a forward movement to discharge the fluid from the barrel. An operating rod projects from the barrel for operating the piston and the rod is operatively connected to the piston with capability of relative axial movement therebetween to approach the piston during its forward movement. A flexible finger has one end connected to the piston or rod and a cutting element is provided on the flexible finger in spaced relation from the connected end thereof and facing the barrel. During retraction movement of the piston, the cutting element is retracted from the barrel whereas during forward travel of the piston and approach of the operating rod towards the piston, a deviation member displaces the flexible finger outwardly to produce cutting of the barrel by the cutting element to render the barrel subsequently unusable.
Patent DE-69006549-D1 (DE)
Inventor: STEIN JUDITH
IPC: C09J7/02
Filed: 1990-06-19
Granted: 1994-03-24
Abstract: A method is provided for enhancing the controlled release characteristics of paper or plastic substrates by applying onto the substrate, a UV curable mixture of an epoxysilicone, an arylonium salt catalyst, such as a diaryliodoniumhexafluoroantimonate and a controlled release additive such as a phenolpropyl-substituted methyldisiloxane or an alkylphenol, such as dodecylphenol. The treated plastic or paper substrate is then subjected to UV irradiation to effect a tack-free cure of the UV curable mixture on the substrate.
Patent DE-69008844-D1 (DE)
Inventor: NOWOTARSKI MARK STEPHEN
IPC: B23K1/19
Filed: 1990-12-24
Granted: 1994-06-16
Abstract: An essentially fluxless soldering process enables a solder coating to be applied to a surface under controlled pressure conditions enabling the volume and shape of the solder to be desirably controlled. Coatings produced by essentially fluxless processes enable joining processes to be carried out in an essentially fluxless manner with highly desirable processing flexibility.
Patent DE-69010798-D1 (DE)
Inventor: CASTELLANA FRANK S
IPC: A61F5/443
Filed: 1990-08-08
Granted: 1994-08-25
Abstract: Occlusive attaching means comprising a first relatively thick adhesive component (A) to be secured to the skin around the stoma and a relatively thin flexible second adhesive component (C) to be secured to the skin at a distance from the stoma. Both adhesive components (A,C) include an occlusive adhesive layer (11,31) formulated as a blend containing one or more water soluble or swellable hydrocolloids dispersed in polyisobutylene along with other optional ingredients. The attaching means can be utilized as part of a one or two-piece ostomy system.
Patent DE-69017673-D1 (DE)
Inventor: WURTMAN RICHARD J
IPC: A23L33/00
Filed: 1990-04-02
Granted: 1995-04-13
Abstract: Methods of reducing post-prandial fluctuations in plasma levels of large, neutral amino acids (LNAA), as well as compositions useful in that method. The foods and compositions comprise a carbohydrate to protein ratio of from about 3:1 to about 6:1 and, in a specific embodiment, a ratio of 4:1, which results in minimizing the variability in responses individuals exhibit to drugs which are LNAA.
Patent DE-69029299-D1 (DE)
Inventor: VAN LEEUWEN PIETER GERRIT
IPC: G11B20/10
Filed: 1990-09-03
Granted: 1997-01-16
Abstract: A circuit for detecting pulses in an electric input signal, which pulses are superposed on a specific reference level (Uref), has an input terminal (1) for receiving the electric input signal, at least a first and a second comparator device (2, 3), switching means (S1), an output terminal (8) and control signal generator means (13) sec . The control signal generator means supply a control signal to the switching means (S1) to control the position of the switching means. The input terminal (1) is coupled to a first input of the comparator devices (2, 3), whose outputs (6 and 7 respectively) are coupled to a terminal (c and arespectively) of the switching means (S1). The output terminal (b) of the switching means is coupled to the output terminal (8). The first comparator device (2) transfers only pulses whose relative amplitude in relation to the reference level exceeds a first value (UD1). The second comparator device (3) transfers only pulses whose relative amplitude in relation to the reference level exceeds a second value (UD2). When input terminal receives N1 consecutive pulses whose amplitude relative to the reference level exceeds a specific (third) value (UD3) the switching means (S1) have been/are set to position c-b in such a manner that the first comparator (2) is coupled to the input terminal (8). When subsequently N2 consecutive pulsews are counted whose relative amplitude lies between a fourth and a fifth value (UD4 and UD5 respectively), such that U<D5> < UD4 < UD3, the switching means (S1) have been/are set to position a-b in such a manner that the second comparator device (3) is coupled to the output terminal (8). N1 and N2 are integers larger than or equal to 1.
Patent DE-69105560-D1 (DE)
Inventor: LARSEN ARTHUR LEE
IPC: C23F11/14
Filed: 1991-02-08
Granted: 1995-01-19
Abstract: Corrosion in liquids in oil fields is prevented by adding an effective amount of a betaine or ampholyte of formula (I) or (II) to the liquids: where R1 = 10-20C alkyl or alkenyl pref. 14-18C alkyl or alkenyl; R2 and R3 = 1-4C alkyl pref. methyl.
Patent DE-69114633-D1 (DE)
Inventor: OLIVER MICHAEL S
IPC: E21B10/25
Filed: 1991-09-11
Granted: 1995-12-21
Abstract: Sealed bearing rotary cone drill bits are subject to seal wear from detritus or debris generated during operation of the drill bit in a borehole. The debris invades the seal gland area resulting in premature cone bearing failure. A shale burn plug secured in the leg back face and positioned between the base of the rotary cone and the leg back face has a shale or detritus diverting ridge formed in the face of the plug. Additionally, the burn plug is energized to urge the ridged face of the burn plug against the base of the rotary cone; the ridge being non-radially oriented to divert debris away from the seal gland. <IMAGE>
Patent DE-69114787-D1 (DE)
Inventor: VINEL PAUL
IPC: H04L12/56
Filed: 1991-07-23
Granted: 1996-01-04
Abstract: Device comprising a memory (MCT) in which there is assigned to each virtual circuit a location containing a context (CT) defining the conditions for evaluating the throughput of this virtual circuit. This context contains a start time which was the current time recorded on the occasion of receiving an earlier cell of the relevant virtual circuit. On receiving each cell, the context of the virtual circuit to which this cell belongs is read, this start time is subtracted from the present current time and the time difference thus established is the basis for evaluating the throughput, and leads to a repressive action (OSC) in the event of excessive throughput. The device furthermore comprises means (HGX, BEX) for proceeding to a cyclic exploration of the said contexts (CT) and, during this cyclic exploration, proceeding, in each context, to the incrementation of an exploration cycle counter having an initial position, as well as additional means for reading, upon arrival of a cell, this exploration cycle counter, noting its relative position, with respect to its initial position, and, when the relative position noted corresponds to a given number of exploration cycles, disabling all repressive action. 
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Patent DE-69119763-D1 (DE)
Inventor: STALLARD WILLIAM
IPC: H04B3/46
Filed: 1991-04-22
Granted: 1996-06-27
Abstract: A fault signalling system for an optical fibre-based communications link having erbium doped fibre amplifier repeaters (20) comprises a broadband optical source (34) for generating a fault signal in the event of a fault occurring. Each repeater includes such a broadband source, which will output a characteristic fault signal onto the link for transmission to a receiving station, in the event of a fault being detected at that repeater. Advantageously, a control circuit which enables the source (34) to emit its fault signal when appropriate is also used as part of an automatic gain control for the output of the amplifier repeater in normal operation.
Patent DE-69119866-D1 (DE)
Inventor: SAVORANI SANDRA
IPC: E03F5/06
Filed: 1991-10-16
Granted: 1996-07-04
Abstract: This invention relates to a modular construction joist (1) made up of a high-strength, composite plastic material, possibly embedding a glass fibre or similar filling material, said joist (1) being suitable for realizing grid-like and closure members which can stand the traffic of pedestrians and vehicles. <IMAGE>
Patent DE-69129093-D1 (DE)
Inventor: GULICK DALE E
IPC: H04M1/253
Filed: 1991-08-27
Granted: 1998-04-23
Abstract: A keypad monitor which monitors the condition of a plurality of switches of a keypad is activated in response to receiving clock signals from an external clock source and is deactivated in the absence of the clock signals. The keypad monitor includes a key switch monitor which detects the closure of any one of the keypad switches to provide a first output signal, a clock detector for detecting the absence of the clock signals to provide a second output signal and any key down output logic which is responsive to the first and second output signals for providing an activation signal. The activation signal causes the external clock source to provide the keypad monitor with the clock signals for activating the keypad monitor.
Patent DE-69132491-D1 (DE)
Inventor: OHTSUBO KAZUO
IPC: H02H9/04
Filed: 1991-09-18
Granted: 2001-01-11
Abstract: There is disclosed a noise-reducing element (1) with at least one junction (4, 5, 6) between component (2, 3) of different kinds of electroconductive materials. The electrodes are constituted by a part of at least of the components. Further, the thermoelectric power of the respective materials in the element exceeds + or - 50  mu VK<-1> at the temperature of the element under the state in which the noise-reducing element is activated. Also, there is rectifying action to a harmless extent at the junction. <IMAGE>
Patent DE-69132833-D1 (DE)
Inventor: BISTRIAN R
IPC: A61P35/00
Filed: 1991-01-23
Granted: 2002-01-10
Abstract: Disclosed is a method of treating cancer using nutritional support therapy by administration of a structured lipid containing both omega 3 fatty acids and medium-chain fatty acids. The therapy may be used as total parenteral nutrition or as a nutritional supplement. The addition of tumor necrosis factor may also be beneficial.
Patent DE-69201293-D1 (DE)
Inventor: TOMMASINI GUALTIERO GIANNI
IPC: B23B15/00
Filed: 1992-10-20
Granted: 1995-03-09
Abstract: Manipulators (M1, M2) capable of gripping a workpiece to be machined are mounted on the tool-carrying slide or slides or on the so-called cross slide or slides (S) of a vertical lathe. The manipulators are preferably located outside the tool stations. The travel movements of the said slide or slides are adapted so that, after machining of the workpiece located on the chuck (G) has been completed, a manipulator (M2) is positioned on the said chuck in order to take hold of and extract the workpiece, while the other manipulator (M1) is positioned, simultaneously, in a loading station (S1) in order to take hold of and raise a new workpiece to be machined. With successive displacements of the said slide or slides, the manipulator (M2) with the machined workpiece is positioned in a station (S2) for receiving and removing the workpiece itself, while the other manipulator (M1) is simultaneously positioned on the chuck (G) in order to insert the new workpiece in the latter. <IMAGE>
Patent DE-69207616-D1 (DE)
Inventor: HATAKEYAMA MASAHIRO
IPC: H01J37/02
Filed: 1992-02-27
Granted: 1996-02-29
Abstract: A fast atom beam source which is capable of emitting a fast atom beam with low energy efficiently and which enables a reduction in the overall size of the apparatus. A reaction gas mixed with a halogen or a halide is introduced into a fast atom beam source casing through a plate-shaped anode (4), and gas ions that are produced by a plasma discharge induced at a relatively low discharge voltage are converted into a fast atom beam, which is emitted from fast atom beam emitting holes provided in a plate-shaped cathode (21) that is disposed to face opposite to the anode.
Patent DE-69209771-D1 (DE)
Inventor: NUSSBAUMER PETER
IPC: C07C67/303
Filed: 1992-10-13
Granted: 1996-05-15
Abstract: The invention concerns the compounds of formula I <CHEM>  wherein the substituents have various significances,  in free form and, where such forms exist, in salt form. The compounds have potent antihyperproliferative / antiinflammatory and anticancer activity.
Patent DE-69221375-D1 (DE)
Inventor: KNECHT GERHARD WERNER
IPC: G08C23/04
Filed: 1992-05-07
Granted: 1997-09-11
Abstract: A repeater for use with remotely controllable domestic appliances particularly those controlled over an infrared link. The repeater comprises a receiver for detecting control signals broadcast by the remote control unit at a location remote from the controlled appliance and an emitter proximate the controlled appliance which re-emits the signals received by the receiver to control the appliance. <IMAGE>