Patent SG-11201900080V-A (SG)
Title: Additive channels
Inventor: LEVNER DANIEL
IPC: B01L3/00
Filed: 2017-07-12
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD HIM 0 11101 HOE 3E1 0 01111110111M Ell 100 HIV 011 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/013654 Al 18 January 2018 (18.01.2018) W I P0 I P C T (51) International Patent Classification: WEN, Norman; 4975 Washington Street, Unit 118, West BOIL 3/00 (2006.01) Roxbury, MA 02132 (US). FRASER, Jacob; 19 Kingston (21) International Application Number: Street, Apt. 2, Somerville, MA 02144 (US). NGUYEN, PCT/US2017/041668 Justin; 45 Cross Street, Apt. 24, Medford, MA 02155 (US). BARRILE, Riccardo; 24 Queensberry Street, Boston, MA (22) International Filing Date: 02215 (US). HAMILTON, Geraldine; 509 East 2nd Street, 12 July 2017 (12.07.2017) Unit 7, Boston, MA 02127 (US). KARALIS, Catherine; 9 Colbourne Crescent, #2, Brookline, MA 02445 (US). (25) Filing Language: English PARK, Hyoung Shin; 42 Summit Street, Newton, MA (26) Publication Language: English 02458 (US). VARONE, Antonio; 4975 Washington Street, Unit 118, West Roxbury, MA 02132 (US). VAN DER (30) Priority Data: MEER, Andries; Renbaanstraat 18, 7523 ZW Enchede 62/361,274 12 July 2016 (12.07.2016) US (NL). OTIENO, Monica; 6 Witmer Way, Robbinville, NJ (71) Applicants: EMULATE, INC. [US/US]; 27 Drydock, 08691 (US). CONEGLIANO, David; 50 Saint Stephen Boston, MA 02210 (US). JANSSEN BIOTECH, INC. Street, #4, Boston, MA 02115 (US). [US/US]; 800/850 Ridgeview Road, Horsham, PA 19044 (74) Agent: CARROLL, Peter, G. et al.; Medlen & Carroll, (US). LLP, 1440 Broadway, Suite 1010, Oakland, CA 94612 (72) Inventors: LEVNER, Daniel; 55 Sewall Avenue, 5C, (US). Brookline, MA 02446 (US). HINOJOSA, Christopher, (81) Designated States (unless otherwise indicated, for every — David; 69 Holworthly Street, Cambridge, MA 02138 (US). kind of national protection available): AE, AG, AL, AM, = Title: ADDITIVE CHANNELS (54) = = 200 211 = = _'- 205 `; _ ,.,- , , •. , ---f- t -c -1-'. Ta e; ` :-.:-- --- \"- 203 = = ..- , ---- • — - ,- 3 ..-- :. , '- ''''' s , • . 202 = — — = A 2e2 • • '-, - • -•., _ .., tit 4 ; = 205 '..- +11111%.1 215 = FIG. 1 ,-, 7r 11 in M (57) : Compositions, devices and methods are described for preventing, reducing, controlling or delaying adhesion, adsorption, C surface-mediated clot formation, or coagulation in a microfluidic device or chip. In one embodiment, blood (or other fluid with blood ---, components) that contains anticoagulant is introduced into a microfluidic device comprising one or more additive channels containing * 1 : one or more reagents that will re-activate the native coagulation cascade in the blood that makes contact with it \"on-chip\" before moving Il cz into the experimental region of the chip. N C [Continued on next page] WO 2018/013654 Al MIDEDIMOMOIDEIREEMOOMMOMMIIIIIIIIIIIIIIII1111111 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))