Patent SG-11201906468T-A (SG)
Title: Chimeric antigen receptors against axl or ror2 and methods of use thereof
Inventor: FROST GREGORY IAN
IPC: A61K39/395
Filed: 2018-01-17
Abstract: 40%- 30% — ap 20%— + 0 0 10% 7 0% 50% 7 7 7 7 7 C4 CO 7 LO CD N. CO 01 CD r 0.1 M V N CO N- CO CV CV CV CV (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) CORRECTED VERSION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 111111111111 0 11011111111111 01101 01111111 111111111100 1110 110 1110 111101111 (10) International Publication Number WO 2018/136570 A9 26 July 2018 (26.07.2018) WI PO I PCT (51) International Patent Classification: CO7K 16/28 (2006.01) 9618 3 9 / 3 95 (2006.01) (21) International Application Number: PCT/US2018/014122 (22) International Filing Date: 17 January 2018 (17.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/447,898 18 January 2017 (18.01.2017) US 62/467,059 03 March 2017 (03.03.2017) US 62/530,193 08 July 2017 (08.07.2017) US (71) Applicant: Fl ONCOLOGY, INC. [US/US]; 625 N. Fla- gler Dr., Suite 625, West Palm Beach, Florida 33401 (US). (72) Inventors: FROST, Gregory Ian; 625 N. Flagler Dr., Suite 625, West Palm Beach, Florida 33401 (US). ONUFFER, James Joseph; 625 N. Flagler Dr., Suite 625, West Palm Beach, Florida 33401 (US). (74) Agent: VACCHIANO, Emanuel J.; 8110 Woodside Lane, Burr Ridge, Illinois 60527 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (54) Title: CHIMERIC ANTIGEN RECEPTORS AGAINST AXL OR ROR2 AND METHODS OF USE THEREOF FIG. 1 60%- U- U- LL LL LL LL u_ u_ LL U- U- U- U- U- U- U- U- U- U- U- U- O Axl Lentriviral Particle N (57) : The present disclosure provides chimeric antigen receptors that bind to Axl and Ror2, and conditionally active chimeric antigen receptors (CARs) that recognize Axl and Ror2. Furthermore, provided herein are nucleic acids encoding these CARs and 00 methods of making and using the CARs, including methods of treating cancer, especially cancers that express Axl and/or Ror2, such O as renal cell carcinoma. The present disclosure provides cells genetically modified to produce the CARs. C [Continued on next page] WO 2018/136570 A9 IMEDIM0110101011MEN0M011101111111111111110111110111111111111 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with amended claims (Art. 19(1)) with sequence listing part of description (Rule 5.2(a)) with information concerning authorization of rectification of an obvious mistake under Rule 91.3 (b) (Rule 48.2(i)) (48) Date of publication of this corrected version: 04 October 2018 (04.10.2018) (15) Information about Correction: see Notice of 04 October 2018 (04.10.2018)