Patent EP-0222962-A1 (EP)
Inventor: BECK ANDREAS DR
IPC: C07D257/04
Filed: 1985-11-18
Abstract: 1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE A novel 4-acylresorcinol ether of the formula  see diagramm : EP0222962,P24,F2  in which R1 is lower alkyl, alk is a hydroxy-lower alkylene radical which can be interrupted by oxygen and R2 is 5-tetrazolyl, it being possible for the ring A to be additionally substituted by lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy and/or halogen and for the ring B to be additionally substituted by lower alkyl, lower alkanoyl, lower alkoxy, lower alkoxycarbonyl, carboxyl, cyano, carbamyl, halogen and/or trifluoromethyl, and it being possible for halogen to have an atomic number not greater than 53 and for "lower" organic groups to have not more than 7 C atoms, or a salt thereof. 1. Claims for the Contracting State : AT A process for the preparation of a novel 4-acylresorcinol ether of the formula  see diagramm : EP0222962,P27,F3  in which R1 is lower alkyl, alk is a hydroxy-lower alkylene radical which can be interrupted by oxygen and R2 is 5-tetrazolyl, it being possible for the ring A to be additionally substituted by lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy and/or halogen and for the ring B to be additionally substituted by lower alkyl, lower alkanoyl, lower alkoxy, lower alkoxycarbonyl, carboxyl, cyano, carbamyl, halogen and/or trifluoromethyl, and it being possible for halogen to have an atomic number not greater than 53 and for "lower" organic groups to have not more than 7 C atoms, or a salt thereof, which comprises a) subjecting a compound of the formula  see diagramm : EP0222962,P27,F4  to a rearrangement or b) reacting a compound of the formula  see diagramm : EP0222962,P27,F5  in which X1 is free or etherified hydroxyl with a compound of the formula R1 -X2 (IV) in which X2 is free or functionally modified carboxyl, or c) in a compound of the formula see diagramm : EP0222962,P28,F1  in which X3 is a radical which can be converted into the group of the formula R1 -C(=O)-, converting X3 into this group or d) in a compound of the formula  see diagramm : EP0222962,P28,F2  in which X4 is a radical which can be converted into hydroxyl, converting X4 into hydroxyl, or e) reacting with one another compounds of the formulae  see diagramm : EP0222962,P28,F3 and  see diagramm : EP0222962,P28,F4  in which one of the radicals X5 and X6 is free hydroxyl or hydroxyl in the form of a salt and the other is a hydroxy-lower alkoxy radical which is substituted by reactive esterified hydroxyl and can be interrupted by oxygen or is an epoxy-lower alkoxy radical which can be interrupted by oxygen, it being possible for "lower" organic groups to have from 3 to not more than 7 C atoms, or f) in a compound of the formula  see diagramm : EP0222962,P28,F5  in which alk' is a group which can be converted into a radical alk, converting alk' into a radical alk, or g) reacting a compound of the formula  see diagramm : EP0222962,P28,F6 or a salt thereof, with a compound of the formula X7 -R2 in which X7 is a free carboxyl group or an esterified or amidised carboxyl group or a carboxyl group in the form of an anhydride or salt, or h) in a compound of the formula  see diagramm : EP0222962,P28,F7  in which X8 is a radical which can be converted into the desired group of the formula -NH-C-(=O)-R2 , converting X8 into this group and, if desired, converting a compound of the formula I obtainable in accordance with the process into another compound of the formula I and/or converting a free compound of the formula I obtainable in accordance with the process into a salt or converting a salt obtainable in accordance with the process into the free compound of the formula I or into another salt.