baber/WOPTO huggingface dataset:
Patent ES-2377062-T3 (ES)
Title: Métodos para determinar un régimen quimioterapéutico basado en la pérdida de heterocigosidad en el locus de timidilato sintasa
Inventor: DANENBERG KATHLEEN
IPC: C12Q1/68
Filed: 2004-02-20
Granted: 2012-03-22
Abstract: Método para predecir una respuesta de un paciente con cáncer a un régimen quimioterapéutico, en el que el régimen comprende un inhibidor de timidilato sintasa (TS) , comprendiendo dicho método: (a) determinar el genotipo del polimorfismo de repetición en tándem en la región potenciadora del gen de TS (TSER) en el tejido normal del paciente;(b) determinar dicho genotipo en el tejido tumoral del paciente;(c) comparar el genotipo de tejido normal con el genotipo de tejido tumoral para determinar si se ha producido en el tejido tumoral una pérdida de heterocigosidad en la TSER; y (d) si hay una pérdida de heterocigosidad, predecir una respuesta al régimen quimioterapéutico basándose en la pérdida de heterocigosidad en la muestra tumoral, en el que (i) una determinación de la presencia de un alelo con repetición triple en TSER (3R) predice un efecto negativo directo sobre la respuesta del tumor al régimen quimioterapéutico;(ii) una determinación de la pérdida de heterocigosidad de 2R/3R en tejido normal a 2R/perdida en tejido tumoral predice una mayor sensibilidad del tumor al régimen quimioterapéutico con respecto a la sensibilidad de un tumor que tiene un genotipo 2R/3R; y/o(iii) una determinación de la pérdida de heterocigosidad de 2R/3R en tejido normal a 3R/perdida en tejido tumoral predice una sensibilidad del tumor al régimen quimioterapéutico similar a la de un tumor que tiene un genotipo 3R/3R.
Patent ES-2289511-T3 (ES)
Inventor: RAATIKAINEN JUHA
IPC: E05B/
Filed: 2004-04-27
Granted: 2008-02-01
Abstract: A door lock includes a latch bolt and an auxiliary bolt. A stop member is supported by the auxiliary bolt and is movable relative to the auxiliary bolt between a position in which it prevents a guide element moving to a position providing deadlocking of the latch bolt, while the auxiliary bolt is in a protruding position, and a position in which it allows the guide element to move to a position providing the deadlocking of the latch bolt. The stop member allows the guide element to move to the position providing deadlocking of the latch bolt only in case both the auxiliary bolt and the latch bolt are first moved to retracted positions.
Patent ES-2275224-T3 (ES)
Inventor: SEIDEL HENNING
IPC: A24B15/00
Filed: 2004-06-01
Granted: 2007-06-01
Abstract: The invention relates to an American Blend -type tobacco mixture containing up to 70 percent by weight of Virginia tobaccos, up to 40 percent by weight of Burley tobaccos, up to 20 percent by weight of oriental tobaccos, and up to 5 percent by weight of other types of tobacco, up to 60 percent by weight of which can be provided as swelling tobacco. According to the invention, all or most of the Burley tobacco is provided as cut reconstituted tobacco foil which is obtained according to the TSNA adsorption method. Preferably, at least 60 percent by weight of the Burley tobacco of the reconstituted tobacco foil consists of lamina while the reconstituted tobacco foil is preferably obtained according to a papermaking method. The invention further relates to cigarettes containing such cut tobacco mixtures.
Patent ES-2372389-T3 (ES)
Inventor: FLINTA CHRISTOFER
IPC: H04L12/24
Filed: 2004-06-30
Granted: 2012-01-19
Abstract: Information about virtual private networks—VPNs—in each domain of a multi-domain communications system is provided. By comparing a request for a configuration of a VPN with the provided information of other connected domains, a match can be found. VPN configuration can then be performed based on the outcome of the match. The provided domain VPN information is in one embodiment spread to other domains under constrictions put by SLAs between domain operators. The spreading of VPN information can be performed regularly or triggered by an external event. In another embodiment, the VPN configuration request is instead spread to different domains.
Patent ES-2335997-T3 (ES)
Inventor: MERCADO HEDELIZA MALONZO
IPC: C11D1/75
Filed: 2004-05-18
Granted: 2010-04-07
Abstract: A bathroom cleaning composition containing a chlorine containing bleach, that is effective in removing mold and mildew as well as removing soap scum.
Patent ES-2356999-T3 (ES)
Inventor: BROWNE YVONNE
IPC: C11D17/00
Filed: 2004-06-14
Granted: 2011-04-15
Abstract: Perfume compositions comprising defined high impact accords and personal cleansing compositions, especially soap bars, comprising those perfume compositions are provided. In a preferred aspect, the perfume compositions are encapsulated in starch or the like so as to release fragrance when exposed to water, such as in the shower.
Patent ES-2280999-T3 (ES)
Inventor: DAMMERS SEBASTIAN
IPC: E05B47/06
Filed: 2004-09-13
Granted: 2007-09-16
Abstract: The invention relates to a closing element for a housing which can be closed, said housing comprising a covering frame which covers the opening of the housing at least in certain areas, at least one closing catch which is arranged in a displaceable manner in the frame, a locking element which is used to lock the at least one closing catch, a manual or motor drive which is used to displace the locking element between a first position, wherein the at least one closing catch, a manual be displaces and is not locked, and a second position, wherein the closing catch is locked by the locking element, also comprising a safety device which is used to lock at least one of the closing catches in the case of fast acceleration and/or a large amount of force being exerted onto the locking element.
Patent ES-2285518-T3 (ES)
Inventor: VAN DEN BERG WOUTER
IPC: B65G17/12
Filed: 2004-08-16
Granted: 2007-11-16
Abstract: A diabolo roller conveyor provided with rotation axles with diabolo rollers mounted thereon, each diabolo roller being divided into two diabolo roller halves by an imaginary dividing plane in which the rotation axle too extends, a locking element being provided having a locked position and a releasing position, while each diabolo roller half is connected to the rotation axle via at least one weighing guide element such that in the releasing position this allows an independent movement of each diabolo roller half parallel to the imaginary plane and perpendicular to the rotation axle for the purpose of weighing an object located on the respective diabolo roller half and that in a locked position the two diabolo roller halves are intercoupled and rotatably drivable through rotation of the rotation axle. An apparatus provided with such a diabolo roller conveyor wherein the apparatus is provided with a weighing cell over which the diabolo rollers are guided.
Patent ES-2327529-T3 (ES)
Title: Diseño de punta de cateter con balon.
Inventor: HOLMAN THOMAS
IPC: A61F2/958
Filed: 2004-08-09
Granted: 2009-10-30
Abstract: Un catéter (10) que comprende un fuste (12), teniendo el fuste (12) una parte proximal, una parte distal, terminando la parte distal en un extremo distal (22), y un conducto transversal, una capa de la punta distal (20), estando la capa de la punta distal (20) en la forma de un tubo y estando colocado aproximadamente en la parte distal del fuste (12), teniendo la capa de la punta distal (20) un extremo proximal y un extremo distal, en el que el extremo distal de la capa de la punta distal (20) se extiende distalmente a al menos el extremo distal (22) del fuste (12), comprendiendo además el catéter (10) un balón médico (16), teniendo el balón (16) una posición de parte de cuerpo entre una cintura proximal y una cintura distal (18), en el que la cintura distal (18) está conectada a la parte distal del fuste (12) y está situada al menos adyacente al extremo proximal de la capa de la punta distal (20), caracterizado porque el fuste (12) comprende una primera capa (13; 34) y una segunda capa (15; 36), estando la segunda capa (15; 36) sobre la primera capa (13; 34), en el que la primera capa (13; 34) y la segunda capa (15; 36) están hechas de materiales diferentes en el que la primera capa está cortada (40) o tiene una pluralidad de cortes circunferenciales.
Patent ES-2378372-T3 (ES)
Inventor: MRONGA NORBERT
IPC: C09C1/00
Filed: 2004-10-23
Granted: 2012-04-11
Abstract: Luster pigments having pronounced sparkle which are based on aluminum platelets which have been coated with iron oxide and have in the precoated state an average platelet size from 8 to 30 mum, an average platelet thickness from 300 to 600 nm and an aspect ratio from 15 to 70.
Patent ES-2285604-T3 (ES)
Inventor: GIRLICH DIETER
IPC: B22D19/14
Filed: 2005-05-31
Granted: 2007-11-16
Abstract: The method for producing reticulated metal structures involves thickening of elements of reticulated foam structures by organic coatings, filling of the resultant structure with a fire-resistant compound, and removal of the foam structure by application of heat before casting operations.
Patent ES-2281049-T3 (ES)
Inventor: CHEN XIXIAN
IPC: H04B1/707
Filed: 2001-10-24
Granted: 2007-09-16
Abstract: A forward link design is provided employing CDMA (code division multiple access) technologies in which time division multiplexing is employed between data and control information on the forward link to service multiple users per slot. Another forward link design employing CDMA (code division multiple access) technologies is provided in which code division multiplexing between data and control information is employed on the forward link to service multiple users per slot, which is preferably backwards compatible with legacy standards such as IS2000A. A reverse link design is also provided.
Patent ES-2293473-T3 (ES)
Title: Administracion intracardiaca de farmaco.
Inventor: BEN HAIM SHLOMO
IPC: A61B19/00
Filed: 1998-02-05
Granted: 2008-03-16
Abstract: Aparato para administración intracardíaca de fármaco, que comprende un catéter (20; 45; 64; 78) el cual, en uso, se inserta dentro de una cámara del corazón (70) y se engancha con un lugar en la pared del corazón (76), comprendiendo el catéter: al menos un sensor de posición magnético (32) para determinar las coordenadas de posición y orientación del catéter generando señales que responden a la posición del catéter dentro del corazón; y un dispositivo de administración de fármaco (24; 47), que está adaptado para administrar una dosis deseada de un fármaco terapéutico en el lugar determinado que responde a las señales del sensor de posición (32), en el que el sensor de posición magnético (32) está adaptado para generar señales que responden a un campo magnético aplicado externamente.
Patent ES-2339257-T3 (ES)
Title: Procedimiento y aparato para la codificacion/decodificacion de audio sin perdida.
Inventor: ENNMI OH
IPC: H03M7/40
Filed: 2005-03-10
Granted: 2010-05-18
Abstract: Un procedimiento de codificación de audio sin pérdida que comprende: correlacionar (600) una señal espectral de audio en el dominio frecuencial que tiene valores de número entero en una señal de plano de bits con respecto a la frecuencia; obtener (610) un bit más significativo y un parámetro Golomb para cada plano de bits; seleccionar (620) una muestra binaria de un plano de bits para ser codificada en el orden desde el bit más significativo hasta el bit menos significativo y desde un componente de menor frecuencia hasta un componente de mayor frecuencia; calcular (630) el contexto de la muestra binaria seleccionada; seleccionar (640) un modelo de probabilidad de la muestra binaria utilizando el parámetro Golomb y los contextos calculados; y codificar aritméticamente sin pérdida (650) la muestra binaria utilizando el modelo seleccionado de probabilidad; caracterizado porque el contexto de la muestra binaria seleccionada está calculado utilizando las significaciones de muestras binarias ya codificadas para cada una de una pluralidad de líneas de frecuencia existentes en el entorno de una línea de frecuencia a la que pertenece la muestra binaria seleccionada; en el que la significación de una muestra binaria es "1" si hay al menos un "1" en planos de bit ya codificados en la línea de frecuencia de la muestra binaria y, si no hay "1" en la línea de frecuencia de la muestra binaria, la significación de la muestra binaria es "0".
Patent ES-2325544-T3 (ES)
Inventor: SABELLE STEPHANE
IPC: A61K8/00
Filed: 2005-02-24
Granted: 2009-09-08
Abstract: A secondary, N-alkylaminated, para-phenylenediamine (I) is new. The substituted para-phenylenediamine is of formula (I) is new. R 1, R 2H, alkyl, monoalkylaminocarbonyl, dialkylaminocarbonyl; R 1+R 2together with the nitrogen atom they substitute a 5-6 link saturated cycle optionally interrupted by one or more N or carbonyl and optionally substituted with one or more alkyl groups; R : 1-10C alkylene optionally interrupted by one or more N or O and optionally substituted with one or more of amino or monoalkylamino or dialkylamino or alkylcarbonyl or amido or monoalkylaminocarbonyl or dialkylaminocarbonyl; Compounds 4-[4-(piperidinyl)butylamino]aminobenzene, N-[3-(4-methylpiperazin-1-yl)propyl]benzene- 1,4-diamine and 4-[2-(piperidinyl)ethylamino]aminobenzene are specifically excluded. Independent claims are included for: (1) A cosmetic composition for the dyeing of keratinic fibers such as the hair comprising, in an appropriate medium, at least one of the claimed compounds; (2) the use of the composition for the dyeing of keratinic fibers, preferably the hair; (3) a ready to use composition comprising a mixture of the claimed composition with one or more oxidant agents: hydrogen peroxide, urea peroxide, bromates of alkali metals, persalts, peracids, oxidase enzymes; (4) a method of dyeing human hair by application of the composition for a sufficient time to attain the desired coloration in the presence of an oxidant agent applied before, simultaneously with or after the composition; and (5) the use of the composition in a device with several compartments, a first compartment containing the composition and a second the oxidant agent. [Image].
Patent ES-2284147-T3 (ES)
Inventor: BASORA ANTONIO
IPC: A47J43/07
Filed: 2005-08-02
Granted: 2007-11-01
Abstract: The apparatus has an activating unit (14) that deforms in a reversible manner and belongs to a control unit (22). The unit (14) separates a locking unit (24) from a stopper (47) of a casing, when a cover (5) is placed on the casing. The control unit (22) is displaced towards an apparatus operating position for engaging a retaining unit (25) with a locking unit (12) before activating a switch (26).
Patent ES-2302176-T3 (ES)
Inventor: HAHN MICHAEL
IPC: B65B43/44
Filed: 2005-01-20
Granted: 2008-07-01
Abstract: The invention relates to a device which is used to deliver packets (1) comprising a pouring spout (2) to a rotating star-shaped element (3). A guiding rail (4), which co-operates with a pouring spout (2) and which is used to receive the bag in a displaceable manner, is provided with a removal end (8). The aim of the invention is to produce a device wherein delivery is simplified and high clock frequencies are ensured. As a result, an upper slider (7) engages with the bags (1) at the pouring spout (2) in the region of the removal end (8) of the guiding rail (4), and a drive unit (9) displaces the upper slider (7) between a removal position (10) on the removal end (8) of the guiding rail (4) and a delivery position (11) of the orbit of the receiving elements (12) of the star-shaped element (3).
Patent ES-2525350-T3 (ES)
Title: Reactivos de inmunoanálisis y procedimientos de uso de los mismos
Inventor: TACHA DAVID
IPC: G01N33/58
Filed: 2005-02-24
Granted: 2014-12-22
Abstract: Un procedimiento de detección de dos o más antígenos en una muestra, que comprende: (i) poner en contacto simultáneamente una muestra, que previamente se ha puesto en contacto simultáneamente con un cóctel de anticuerpos primarios que comprende al menos un primer anticuerpo primario y al menos un segundo anticuerpo primario en una disolución acuosa tamponada para el cóctel de anticuerpos primarios, con una composición que comprende al menos un primer anticuerpo secundario y al menos un segundo anticuerpo secundario para formar al menos dos complejos de antígeno-anticuerpo en la muestra, en el que el al menos un primer anticuerpo secundario se acopla con un resto de poli(fosfatasa alcalina) (poli-ALP) y el al menos un segundo anticuerpo secundario se acopla con un resto de poli(peroxidasa de rábano picante) (poli-HRP), y en el que la composición comprende un tampón para el primer y segundo anticuerpos secundarios; y (ii) detectar los al menos dos complejos de antígeno-anticuerpo en la muestra.
Patent ES-2330349-T3 (ES)
Title: Neumatico.
Inventor: SAKAMAKI YUJI
IPC: B60C11/11
Filed: 2005-04-08
Granted: 2009-12-09
Abstract: Un neumático que incluye, sobre una banda de rodadura (10), una pluralidad de filas de bloques (11, 12), definida mediante unos surcos circulares principales (14) extendidos en una dirección circular del neumático y con unos surcos laterales (16) que se cruzan con los surcos circulares principales, en el que una longitud total de una lámina perteneciente a un bloque sobre una superficie de la banda de rodadura es mayor en un bloque (11) dispuesto sobre una región terminal de la banda de rodadura que en un bloque (12) dispuesto sobre una región central de la banda de rodadura, caracterizado porque un índice de rigidez de la lámina (F) se calcula mediante la fórmula (F) = (1 + *1) x (1 + *2) x (1 + *3) en base a una amplitud (*1) en sección transversal en la dirección de la banda de rodadura como intervalo de oscilación de la lámina sobre la sección transversal en una dirección de la banda de rodadura, siendo la sección transversal aproximadamente paralela a una superficie de la banda de rodadura del bloque, sobre una amplitud (*2) en sección transversal circular como intervalo de oscilación de la lámina sobre la sección transversal del bloque en la dirección circular, y sobre la amplitud (*3) en sección transversal en la dirección de la anchura como intervalo de oscilación de la lámina sobre la sección transversal del bloque en una dirección de la anchura, y el bloque (11) dispuesto sobre la región terminal de la banda de rodadura tiene una configuración de lámina en la cual está presente al menos una amplitud entre la amplitud (*2) en sección transversal circular y la amplitud (*3) en sección transversal en la dirección de la anchura, y el índice de rigidez de la lámina (F) del bloque (11) dispuesto sobre la región terminal de la banda de rodadura es mayor que el índice de rigidez de la lámina (F) del bloque (12) dispuesto sobre la región central de la banda de rodadura.
Patent ES-2297753-T3 (ES)
Inventor: CAO YANG
IPC: G01N33/573
Filed: 2005-07-28
Granted: 2008-05-01
Abstract: The present invention relates to a novel and useful method for assaying compounds and agents for their ability to decrease or inhibit the activity of hematopoietic prostaglandin D2 synthase (hPGDS). Specifically, the present invention relates to assays for measuring the potency, specificity and toxicity of hPGDS inhibitors.
Patent ES-2317320-T3 (ES)
Inventor: SCHWALM DIETER
IPC: F16L33/22
Filed: 2005-10-08
Granted: 2009-04-16
Abstract: A pipe connection includes a metal locking ring which can be pushed onto the external pipe of two interlocking metal pipes to connect the latter. The inner face of the locking ring has a leading section that tapers conically in a radial direction in opposition to the direction of application; a trailing section that tapers conically in a radial direction in opposition to the direction of application and that causes the pipe to be radially compressed, when the ring is in the locking position; and a central section lying between the leading section and the trailing section. A central section with a conical configuration improves a pipe connection of this type so that the tensile strength of heavy duty pipe connections or pipe connections consisting of pipes of material with low elasticity becomes mechanically more stable.
Patent ES-2306277-T3 (ES)
Inventor: GLOTZL REINER
IPC: B65G21/20
Filed: 2005-11-19
Granted: 2008-11-01
Abstract: A conveyor device for bottles in particular, having a frame and a replaceable guide for the material, the guide being lockable on the frame for the material to be conveyed. To make such a guide easier to handle, easier to store and easier to install, the guide is designed in multiple parts, a first guide part being provided with a central lock device and designed as a locking means for a second guide part which is equipped with a locking stop.
Patent ES-2290927-T3 (ES)
Inventor: NISHIMURA ISSEI
IPC: H04N21/64
Filed: 2006-02-02
Granted: 2008-02-16
Abstract: A relay apparatus 30 issues a new sub-address at a timing when mobile phones (10a, 10b) requested content from a CP server apparatuses (20a, 20b), that is, at a timing when a sub-address is required. The content specified by this sub-address is distributed from the CP server apparatuses via the relay apparatus (30) to the mobile phones. In system of the present invention it is possible to utilize the same sub-address many times for different content items., It is therefore possible to avoid increasing the number of digits of the sub-address as well as the complexity of the sub-address structure, in a case where the types of content or the number of content items increases.
Patent ES-2339471-T3 (ES)
Title: Portaherramientas.
Inventor: MAIER JOHANN
IPC: B23B27/16
Filed: 2006-02-17
Granted: 2010-05-20
Abstract: Portaherramientas con una garra de sujeción (1) para inmovilizar una pieza insertada de corte (2) intercambiable, pasando un tornillo tensor (3) por la garra de sujeción (1) y pudiendo unirse la misma mediante tornillo con el cuerpo base (4) del portaherramientas apretándose la garra de sujeción (1) mediante un extremo (6) de un resorte (5) que envuelve el tornillo tensor (3) contra la cabeza del tornillo tensor (3), caracterizado porque el otro extremo (7) del resorte (5) se apoya en un collar (8) del tornillo tensor (3) por encima de la rosca (8) y porque el resorte (5) está realizado de forma cónica y se apoya con su diámetro menor en el tornillo tensor (3).
Patent ES-2320371-T3 (ES)
Inventor: KOHLER FRIEDER
IPC: G05B13/02
Filed: 2006-10-20
Granted: 2009-05-21
Abstract: The device has a position controller (1) for generation of rotational speed reference value from a position reference value and a position actual value. A model, differentiator (12) and multiplier (11) are provided for generation of pre control current from the position reference value, where the pre-control current is added to a reference current value. The pre-control current is provided to a model for torsion pre-controlling of a shaft between a drive and an object, where output signal of the model is added to the rotational speed reference value.
Patent ES-2302290-T3 (ES)
Inventor: WOHLFART RAINER DR
IPC: A61Q19/08
Filed: 2006-12-21
Granted: 2008-07-01
Abstract: Combination (A) of active agents for topical or dermatological use comprises (i) grapeseed oil (X) and (ii) an acetylenic acid or derivative (I). Combination (A) of active agents for topical or dermatological use comprises (i) grapeseed oil (X) and (ii) an acetylenic acid or derivative of formula (I) or its salt. D-B-Ctriple boundC-A-CH=CH-E-G (I) A : bond or (CH2)n; n : 1-6; B and E : 2-12C alkylene or alkenylene; D and G each : COR, or one is COR and the other is hydrogen or Me; each R : hydroxy, Me, Et or amino.