Patent SG-11201908238S-A (SG)
Title: Anti-c5 antibodies and uses thereof
Inventor: SONG WENCHAO
IPC: C12N15/09
Filed: 2018-03-06
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 13 September 2018 (13.09.2018) WIPO I PCT ill 1111u°111110111sOHolo mu imiloilionflom oimIE (10) International Publication Number WO 2018/165062 Al (51) International Patent Classification: A61K 39/395 (2006.01) C07K 16/28 (2006.01) C07K 16/00 (2006.01) C07K 16/46 (2006.01) C07K 16/18 (2006.01) C12N 15/09 (2006.01) (21) International Application Number: PCT/US2018/021001 (22) International Filing Date: 06 March 2018 (06.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/467,498 06 March 2017 (06.03.2017) US (71) Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENSYLVANIA [US/US]; 3160 Chesnut Street, Suite 200, Philadelphia, PA 19104 (US). (72) Inventors: SONG, Wenchao; 213 Cornell Drive, Bryn Mawr, PA 19010 (US). SATO, Sayaka; 2130 Locust Street, Apt. Al, Philadelphia, PA 19103 (US). MIWA, Takashi; 191 Presidential Blvd., Unit 323, Bala Cynwyd, PA 19004 (US). GUILLIPALLI, Damodar; 4007 Woodland Av- enue, Apt. 13, Philadelphia, PA 19106 (US). (74) Agent: HAAS, Dennis, L. et al.; Riverside Law, LLP, Glenhardie Corporate Center, 1285 Drummers Lane, Suite 202, Wayne, PA 19087 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (54) Title: ANTI-CS ANTIBODIES AND USES THEREOF 1.6 A 1.2 1.0 11.8 0.6 OA 0.2 0.0 -6-4E7 .0.868 105 ite2(31 -to-1109 43-8E1 25 12.5 6.25 3.125 1.5625 0.78 0.39 Antibody Concentration wing) Figure 1 1 -1 (57) : This invention relates to inhibition of the complement signaling using an C5 antibody. Specifically, the invention relates 0 to methods of treating a complement- mediated disease or complement-mediated disorder in an individual by contacting the individual \" with an anti-CS antibody. [Continued on next page] C WO 2018/165062 Al MIDEDIM01101 DIDIIMEN1111111111111111110111111111111111111111111111111111 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))