baber/WOPTO huggingface dataset:
Patent TW-202314197-A (TW)
Inventor: CHANG JUI-PING
IPC: G01D5/12
Filed: 2021-09-27
Abstract: 一種免電池旋轉檢測裝置，可與一旋轉元件組裝，並包含旋轉載具、第一磁性件、第二磁性件及至少一檢測線圈組。旋轉載具可與旋轉元件組裝。第一磁性件設置於旋轉載具。第二磁性件設置於旋轉載具，且與第一磁性件相間隔。及至少一檢測線圈組位於第一磁性件與第二磁性件之間。其中旋轉載具可受旋轉元件帶動，使所述的旋轉載具、第一磁性件及第二磁性件同步旋轉，至少一檢測線圈組感應所述的第一磁性件與所述的第二磁性件間的磁場變化產生一電訊號。
Patent TW-202219601-A (TW)
Title: 顯示裝置
Inventor: MIN KYOUNG-IL
IPC: H01L51/52
Filed: 2017-06-09
Abstract: 本發明提供一種顯示裝置，其包括：包括下表面和與下表面相對的上表面之顯示面板；位於顯示面板的下表面下方，並且包括定義在其中的薄膜槽之第一薄膜；在顯示面板的上表面上方之第二薄膜；以及位於顯示面板的下表面及第一薄膜之間，並包括定義於其中以與薄膜槽重疊的黏合槽之黏合層。此外，顯示面板包括定義下表面的基底基板，且基底基板的第一部分由薄膜槽露出。此外，由薄膜槽和黏合槽所暴露的基底基板的第一部分的結晶度與跟第一薄膜和黏合層重疊的基底基板的第二部分的結晶度差約為5%。
Patent TW-202235672-A (TW)
Title: Methods and apparatus to reduce pressure fluctuations in an ampoule of a chemical delivery system
Inventor: DURUKAN ILKER
IPC: C23C16/52
Filed: 2021-11-19
Abstract: Methods and apparatus to reduce pressure fluctuations in a chemical delivery system for a process chamber are provided herein. In some embodiments, a chemical delivery system for a process chamber, includes: a carrier gas supply; an ampoule fluidly coupled to the carrier gas supply via a first supply line, wherein the ampoule is configured to supply one or more process gases to the process chamber via a second supply line; an inlet valve disposed in line with the first supply line to control a flow of a carrier gas from the carrier gas supply to the ampoule; and a first control valve disposed in line with a pressure regulation line, wherein the pressure regulation line is fluidly coupled to the first supply line at a tee location between the carrier gas supply and the inlet valve.
Patent TW-202231040-A (TW)
Inventor: RAISSINIA ALIREZA
IPC: H04L27/26
Filed: 2021-12-10
Abstract: 本案內容提供了用於改良安全長訓練欄位（LTF）傳輸的安全性的方法、設備和系統。在一些實現中，傳輸設備可以在頻域中對安全LTF執行加窗，使得所得到的時域LTF信號難以（若不是不可能的話）由觀察到LTF信號的一部分的任何設備預測。在一些態樣中，傳輸設備可以基於在精細時序量測（FTM）程序開始時交換的FTM協商訊框來與接收設備協商對安全LTF的加窗。在一些其他態樣中，傳輸設備可以動態地或自我調整地對安全LTF執行加窗。在此種態樣中，傳輸設備可以基於在包括安全LTF的實體層彙聚協定（PLCP）協定資料單元（PPDU）的信號欄位中攜帶的資訊來指示是否對安全LTF執行加窗。
Patent TW-202322706-A (TW)
Title: Method for preparing fish essence removing fish oil on a surface layer of the crude fish essence to obtain the fish essence
Inventor: YANG MING-HUA
IPC: A23L23/10
Filed: 2021-12-14
Abstract: This invention provides a method for preparing fish essence, including the following steps: (a) providing a fish raw material, the fish raw material meeting the freshness and ready-to-eat standards and including sailfishes; (b) cleaning the fish raw material, removing the head and the tail, scraping the scales, and then, blanching the fish raw material in 100DEG C boiling water for 5 to 10 min to obtain a blanched fish raw material; (c) adding wine and water into the blanched fish raw material, and performing stewing at 85DEG C to 100DEG C for 48 hours to obtain crude fish essence; and (d) removing fish oil on a surface layer of the crude fish essence to obtain the fish essence. The fish essence prepared by using the method provided by this invention has no fishy smell, contains high concentrations of tryptophan, arginine, alanine, glycine and proline, and does not substantially contain histidine so as to be capable of improving the function of a human body; and the fish essence has no risk of histidine poisoning, such as allergies, so as to be safe for drinking.
Patent TW-202242120-A (TW)
Title: Increased packaging efficiency of vector for cardiac gene therapy
Inventor: SWEENEY HUGH LEE
IPC: A61K48/00
Filed: 2021-12-22
Abstract: The present disclosure is related to compositions and methods useful in treating heart conditions. The disclosed compositions and methods are based on gene therapies comprising a recombinant AAV vector for delivering two or more transgenes into the heart of a subject, wherein the transgenes encode an S100A1 protein and a cardiac Apoptosis Repressor with caspase recruitment Domain (cARC) apoptotic inhibitor, respectively. In various embodiments, the compositions and methods disclosed herein comprise vectors comprising S100A1 and/or cARC cDNA sequences that are codon-optimized for expression in humans. In various embodiments, the compositions and methods disclosed herein comprise vectors with improved packaging efficiencies. In some aspects, targeting multiple sources of one or more heart conditions can provide synergistic benefits during treatment.
Patent TW-202241397-A (TW)
Title: Transdermal amphetamine compositions with low levels of carbamate
Inventor: SONOBE ATSUSHI
IPC: A61K47/32
Filed: 2022-01-06
Abstract: Described are methods for reducing the formation of amphetamine carbamate and amphetacarbamate in transdermal amphetamine compositions, compositions with low levels of amphetacarbamate, and methods using such compositions for transdermal delivery of amphetamine.
Patent TW-202331490-A (TW)
Title: System, device and method for multi-purpose of a financial quotes application on a tv
Inventor: CHIU HUNG-CHE
IPC: G06F3/048
Filed: 2022-01-20
Abstract: This disclosure is related to a device and method for multi-purpose financial quotes application on a TV. The financial quotes application on TV displays financial quotes by default, and it can also display second-purpose information, such as welcome message, by scheduling through a server. While the second-purpose information is displayed on the TV screen, the financial quotes can be displayed at the same time as well.
Patent TW-202332849-A (TW)
Inventor: NISHIYAMA TATSUYA
IPC: F16K27/12
Filed: 2022-02-15
Abstract: The invention provides a waterproof solenoid valve which can reliably operate a manual button of a solenoid valve body through an operation part of a waterproof cover. The waterproof cover (4) is provided with an operation part (52) for performing pressing operation on a manual button (47) of the solenoid valve body (3). The operation part (52) is provided with a flexible cover member (54); a pin guide (55) interposed between the cover member (54) and the solenoid valve body (3); and an operation pin (57) which is inserted in a guide hole (56) of the pin guide (55) in a displaceable manner, the cover member (54) has a soft pressing part (64) for pressing operation, one end of the operation pin (57) abuts against or approaches the pressing part (64), and the other end of the operation pin (57) abuts against the manual button (47).
Patent TW-202248614-A (TW)
Inventor: POIKAT RALF
IPC: G01M11/02
Filed: 2022-02-23
Abstract: 本發明關於一種用於測量光學系統（4）的成像特性的裝置（2），其中，所述裝置（2）包括：被設置用於將待測試的光學系統（4）定位在預定的測試位置處的試樣保持器（6）、剛性的保持裝置（8）和多個MTF測量裝置（20），所述多個MTF測量裝置（20）被布置在所述保持裝置（8）的可固定預定的位置處，使得藉助所述MTF測量裝置（20）中的每個能夠在所述光學系統（4）的像場中的彼此不同的、同樣可固定預定的角位置處測量調製傳遞函數。所述裝置進一步改進使所述保持裝置（8）至少包括第一和第二保持器（10，12），並且所述多個MTF測量裝置（20）包括第一組和第二組MTF測量裝置（20），其中，所述第一保持器（10）被設置用於將所述第一組MTF測量裝置（20）保持在第一位置處，使得所述第一組MTF測量裝置（20）布置在第一球殼上，所述第二保持器（12）被設置用於將所述第二組MTF測量裝置（20）保持在第二位置處，使得所述第二組MTF測量裝置（20）布置在第二球殼上，其中，所述第一球殼和所述第二球殼具有不同的半徑並且彼此同心地布置。
Patent TW-202241051-A (TW)
Inventor: KNEE DEREK LESLIE
IPC: H03K19/02
Filed: 2022-02-24
Abstract: Superconducting output amplifiers with interstage filters and related methods are described. An example superconducting output amplifier includes a first superconducting output amplifier stage and a second superconducting output amplifier stage. The superconducting output amplifier may further include a first terminal for receiving a first single flux quantum (SFQ) pulse train and coupling the SFQ pulse train to each of the first superconducting output amplifier stage and the second superconducting output amplifier stage. The superconducting output amplifier may further include an interstage filter comprising a damped Josephson junction (Josephson junction; JJ) coupled between the first superconducting output amplifier stage and the second superconducting output amplifier stage, where the interstage filter is arranged to reduce distortion in an output voltage waveform generated by the superconducting output amplifier in response to at least the first SFQ pulse train.
Patent TW-202333911-A (TW)
Title: Dustproof structure of grinding tool holder which defines a plurality of dust blocking points to prevent dust from entering the assembly port
Inventor: CHENG DING-YAO
IPC: B25D17/18
Filed: 2022-02-24
Abstract: Provided is a dustproof structure of a grinding tool holder. The grinding tool holder includes a shaft part and a counterweight part connected to one end of the shaft part. The counterweight part includes an eccentric block connected to the shaft part, at least one bearing mounted on the eccentric block, a dustproof ring, and a grinding member assembly head assembled with the bearing. The eccentric block is formed to provide an assembly port in which the bearing and the dustproof ring are arranged. The dustproof ring is disposed on the side of the bearing facing the grinding member assembly head, and the dustproof ring is formed with a first continuous concave-convex structure on the side away from the bearing. The grinding member assembly head is formed with a second continuous concave-convex structure on the side facing the dustproof ring. The first continuous concave-convex structure is in cooperation with the second continuous concave-convex structure to jointly define a plurality of dust blocking points.
Patent TW-202249117-A (TW)
Inventor: CLARK ROBERT
IPC: H01J37/32
Filed: 2022-03-07
Abstract: 在一範例中，一種處理基板的方法包括將基板裝載到製程腔室中，其中基板包括待蝕刻的含金屬氧化物膜。該方法還包括執行包括複數循環製程的原子層蝕刻，該複數循環製程的每一者包括將含金屬氧化物膜曝露於包括三氯化硼(BCl
         3 )的第一氣體流，以及將含金屬氧化物膜曝露於第二氣體流，該第二氣體流包括硼烷、胺、醇、羧酸、羧醯胺、或β-二酮試劑。
Patent TW-202301701-A (TW)
Inventor: KIM JAE-HO
IPC: H01L31/042
Filed: 2022-03-09
Abstract: 本發明提供一種太陽能電池及其製造方法。太陽能電池包含半導體基板、第一半導體層、第二半導體層、第三半導體層、第一透明導電層及第一電極。第一半導體層提供於半導體基板的表面上。第二半導體層提供於第一半導體層的表面上。第三半導體層提供於第二半導體層的表面上。第一透明導電層提供於第三半導體層的表面上。第一電極提供於第一透明導電層的表面上，其中第二半導體層包含p型半導體材料，且第三半導體層包含含鎢p型半導體材料。
Patent TW-202304340-A (TW)
Title: Insole manufacturing method
Inventor: NAKAGAWA SATOSHI
IPC: B29D35/00
Filed: 2022-03-10
Abstract: To provide an insole that fits a buyer's feet easier. This insole manufacturing method involves: a first step in which a thermoplastic resin is used that melts at a prescribed temperature and a foot-shape resin unit 12 is formed that has the shape of a foot with a prescribed thickness; a second step in which, after shrink processing has been performed cover the foot-shape resin unit 12 with a film, the foot-shape resin unit covered with the film is vacuum packed in a nylon plastic bag; a third step in which an insole 10 manufactured with the first step and the second step is heated at a prescribed temperature; and a fourth step in which the insole 10 having the foot-shape resin unit 12 melted in the third step is attached to the inside of the user's shoe 2, and the foot-shape resin unit 12 is cured a prescribed time has elapsed during which the user wears the shoe 2.
Patent TW-202335717-A (TW)
Title: Liquid-liquid separation device and separation method thereof wherein the liquid-liquid separation device includes an outer sleeve, a spiral sleeve and an auxiliary substance
Inventor: CHIANG YA-YU
IPC: B01D15/14
Filed: 2022-03-11
Abstract: A liquid-liquid separation device which includes an outer sleeve, a spiral sleeve, and an auxiliary substance. The outer sleeve is provided with a sleeve, and a first wall and a second wall connected to the sleeve and located at two opposite far ends of the sleeve, the sleeve defines a first space, and the first wall is provided with a an input port communicating with the first space, the second wall is provided with a liquid outlet and an output port communicating with the first space, and the positions of the input port and the output port are opposite to each other. The spiral sleeve is provided with a spiral tube, an injection tube and an output tube arranged in the first space, two ends of the spiral tube are respectively arranged corresponding to the input port and the output port and define a second space communicating with the input port and the output port. One end of the injection tube is inserted into the input port and extends to the second space, and is provided with a first injection port, and a second injection port, one end of the output tube is inserted into the output port and extends to the second space, and the two ends of the spiral tube are respectively connected to the injection pipe and the output tube. The auxiliary substance is arranged on the outer side surface of the spiral tube and has similar hydrophilicity and hydrophobicity to one of the fluids. In addition, the present invention also provides a liquid-liquid separation method.
Patent TW-202247421-A (TW)
Title: Semiconductor device with memory element
Inventor: HARADA NOZOMU
IPC: G11C11/401
Filed: 2022-03-17
Abstract: The present invention provides a semiconductor with memory element, the memory element containing a dynamic flash memory cell which has a HfO 2  layer 15 and a TiN layer 16 surrounding a lower portion of a Si column 11A standing on a P layer substrate 10, a HfO 2  layer 18a surrounding an upper portion of the Si column 11A, a TiN layer 19a, and N +  layers 13a and 13b connected to the bottom portion and the top portion of the Si column 11A, and a SGT transistor which has a SiO 2  layer 23 surrounding a lower portion of a Si column 11B standing on the same P layer substrate 
10, a HfO 2  layer 18b surrounding an upper portion of the Si column 11B, a TiN layer 19b, and N +  layers 13c and 13d sandwiching the HfO 2  layer 18b and connected to the top portion and middle portion of the Si column 11B in a vertical direction, wherein the bottom positions of the Si column 11A and the Si column 11B are located at the same position A, and a bottom portion of an upper transistor portion of the dynamic flash memory cell composed of the HfO 2  layer 18a and the TiN layer 19a on the upper portion of the Si column 11A is at the same position B with a bottom portion of a SGT transistor portion composed of the HfO 2  layer 18b and the TiN layer 19b on the upper portion of the Si column 11B.
Patent TW-202241702-A (TW)
Title: Copper foil with carrier, copper-clad laminate, and printed wiring board
Inventor: HOSOKAWA MAKOTO
IPC: B32B15/04
Filed: 2022-03-23
Abstract: Provided is a copper foil with a carrier, with which excellent laser processability can be achieved. This copper foil with a carrier is provided with a carrier, a release layer, and an ultrathin copper foil in said order, wherein copper crystal grains that are present on the release-layer-side surface of the ultrathin copper foil have a plane size S1 of 50 nm to 600 nm as measured using an electron backscatter diffraction (EBSD) method.
Patent TW-202307646-A (TW)
Title: Method, device and system for processing data
Inventor: KHWA WIN-SAN
IPC: G06F7/52
Filed: 2022-04-19
Abstract: A method, device, and system for performing a partial sum accumulation of a product of input vectors and weight vectors in a wordwise-input and bitwise-weight manner results in a partial accumulated product sum. The partial accumulated product sum is compared with a threshold condition after each weight bit, and when the partial accumulated product sum meets the threshold condition, a skip indicator is asserted to indicate that remaining computations of a sum accumulation are skipped.
Patent TW-202249395-A (TW)
Title: Motor and fan using same, and motor cartridge
Inventor: UCHIKAWA SHINICHI
IPC: F04D29/049
Filed: 2022-05-13
Abstract: Provided are a motor in which a shaft, bearings, and the like can be prevented from moving with respect to a case, a fan using the motor, and a motor cartridge. This motor (100) comprises: a shaft (1); a rotor (3) fixed to the shaft (1); a stator (6) facing the rotor (3); a pair of bearings (4) fixed to the shaft (1); a sleeve (5) surrounding the pair of bearings (4); and a case (7) having a supporting portion (76) for supporting the sleeve (5). The sleeve (5) has an engaging portion (51) engaging with the case (7) in the axis X direction of the shaft (1).
Patent TW-202313997-A (TW)
Title: Molten steel secondary refining method and steel production method
Inventor: TADA CHIKASHI
IPC: C22B9/05
Filed: 2022-06-02
Abstract: To provide a molten steel secondary refining method enabling nitrogen concentration to stably reach low nitrogen concentration zone at high speed without causing an operation problem, and a steel production method. A secondary refining method is provided in which an Al addition step of adding a metal Al-containing substance to molten steel to form Al-containing molten steel and a CaO addition step of adding a CaO-containing substance to molten steel are combined to form slag containing CaO and Al2O3, then an acid transfer treatment including a denitrification treatment in which oxygen-containing gas is blown to the Al-containing molten steel through the slag is performed, wherein based on the stirring power density [epsilon](W/t) upon slag formation, an Al concentration [Al]i(mass%) in the molten steel immediately before the acid transfer treatment is set to be a value [Al]e or more calculated by the following formula (A), and the Al concentration [Al]f at the end of the acid transfer treatment is set to be 0.03 mass% or more. A steel production method is also provided in which the obtained molten steel is cast after composition adjustment. [Al]e=-0.072*ln([epsilon])+0.5822 (A).
Patent TW-202303003-A (TW)
Title: Vacuum pump
Inventor: KABASAWA TAKASHI
IPC: F04D29/58
Filed: 2022-06-15
Abstract: To provide a vacuum pump that is easy to assemble and disassemble, further, it can cool a rotator sufficiently. A vacuum pump comprising: a housing 126 whose one end is leading to an inlet port 101, and the other end is leading to an exhaust port 133, a cooling means 130 mounted in the housing 126, a rotator 103 mounted in the housing 126, a plurality of fixed wings 123 mounted between rotary wings, a plurality of fixed wing spacers 125 supporting the fixed wings 123, wherein a joint fitting structure of an outer peripheral surface 125O of the fixed wings 123 or the fixed wing spacers 125 and an inter peripheral surface 126I of the housing 126 forms a gap between the outer peripheral surface of the fixed wings 123 and the inner peripheral surface of the housing 126 below temperature during assembly work. the outer peripheral surface 123O of the fixed wings 123 and the inner peripheral surface 126I of the housing 126 forms an interference fit at target temperature higher than the temperature during assembly work.
Patent TW-202309657-A (TW)
Inventor: SUZUKI TETSUAKI
IPC: H01L21/027
Filed: 2022-06-17
Abstract: 本發明之課題係提供感光性聚醯亞胺樹脂組成物，其目的在於：具備顯影時的顯影液可溶性與光交聯後的顯影液不溶性，可達成良好膜物性與高感度，且不會發生樹脂覆膜的膜厚減少或龜裂、基板翹曲或破壞。
        本發明之解決手段所提供的感光性聚醯亞胺樹脂組成物，係含有溶劑可溶性聚醯亞胺與二疊氮化合物的感光性聚醯亞胺樹脂組成物，其中，溶劑可溶性聚醯亞胺係同一重複單元中具有：(a)脂環式酸二酐殘基、以及(b)從胺基之鄰位具烷基之芳香族二胺、及具茚烷結構之芳香族二胺所構成群組中選擇至少1種二胺之殘基的嵌段共聚合體。
Patent TW-202317138-A (TW)
Inventor: SALITURO FRANCESCO G
IPC: A61K31/575
Filed: 2017-10-18
Abstract: 本發明提供根據式(I)之化合物：
         及其醫藥學上可接受之鹽以及其醫藥組合物；其中R
         1 、R
         2 、R
         3 、R
         4 、R
         5 、R
         6 及R
         G 如本文所定義。預期本發明之化合物適用於預防及治療各種病狀。
Patent TW-202310461-A (TW)
Title: Imaging devices having piezoelectric transceivers with harmonic characteristics
Inventor: KWON HAESUNG
IPC: G01S7/521
Filed: 2022-06-30
Abstract: A micromachined ultrasonic transducer (MUT) which comprises a first piezoelectric layer and a second piezoelectric layer. The first piezoelectric layer is disposed between a first electrode and a second electrode. The second piezoelectric layer is disposed between the second electrode and a third electrode. At least the first electrode has first and second ends along a first axis, one or more of which is defined by a radius of curvature R. A second axis normal to the first passes through a midpoint of the first axis. A half-width of the first electrode is defined by a length L measured from the midpoint, in the direction of the second axis, to an outer perimeter of the first electrode. A total width of the first electrode at its narrowest point along the first axis is at most 2L such that the first electrode has a concave shape. R/L is greater than 1.
Patent TW-202334925-A (TW)
Title: Display panel
Inventor: CHIEN I-PENG
IPC: G09G3/30
Filed: 2022-07-08
Abstract: The present disclosure provides a display panel including pixels and a metal layer below the pixels. The metal layer includes a body portion in the center of the display panel and a mesh portion at the edge of the display panel adjacent to the body portion. A contour of the body portion defines a first region of the display panel, and first pixels in the first region are electrically connected to the body portion. A contour of the mesh portion defines a second region of the display panel, and second pixels in the second region are electrically connected to the mesh portion. The mesh portion and the body portion are electrically connected, a first metal density of the first region is higher than a second metal density of the second region, and an area of the second region is 20% to 40% of an area of the display panel.
Patent TW-202321824-A (TW)
Inventor: WINTERS JASPER
IPC: G03F7/20
Filed: 2022-07-22
Abstract: A method for improved sequencing of light delivery in a lithographic process includes determining a sequence of intensities of light to be delivered that includes an interval within the sequence of intensities where substantially no light is delivered to the substrate and delivering light to a substrate by a light source utilizing a digital mirror device (DMD) according to the sequence of intensities.
Patent TW-202313449-A (TW)
Title: 3d-printed hydrogen storage systems using non-pyrophoric hydrogen storage alloys
Inventor: LEE HENRY U
IPC: C01B3/00
Filed: 2022-07-22
Abstract: A hydrogen storage system includes a hydrogen storage alloy containment vessel comprising an external pressure containment vessel and a thermally conductive compartmentalization network disposed within the pressure containment vessel. The compartmentalization network creates compartments within the pressure vessel within which a hydrogen storage alloy is disposed. One or both of the compartmentalization network and the pressure vessel may be formed by s 3D printing process, such as by Selective Laser Melting (SLM) and/or Direct Metal Laser Sintering (DMLS). The hydrogen storage alloy is a non-pyrophoric AB
         2 –type Laves phase hydrogen storage alloy having: an A-site to B-site elemental ratio of not more than 0.5; and an alloy composition including (in at%): Zr: 2.0 - 5.5, Ti: 27 - 31.3, V: 8.3 - 9.9, Cr: 20.6 - 30.5, Mn: 25.4 - 33.0, Fe: 1.0 - 5.9, Al: 0.1 - 0.4, and/or Ni: 0.0 - 4.0.
Patent TW-202309305-A (TW)
Title: Solder alloy and solder joint
Inventor: YOKOYAMA TAKAHIRO
IPC: H05K3/34
Filed: 2022-08-16
Abstract: Provided are a solder alloy and a solder joint, which have a narrow [Delta]T to suppress solder bridges and solder icicles, and a small amount of dross generated in a solder tank, suppress Cu leaching, and have higher strength. The solder alloy has an alloy composition consisting of, by mass%, Cu: more than 2.0% and less than 3.0%; Ni: 0.010% or more and less than 0.30%; and Ge: 0.0010 to 0.20% with the balance being Sn. Preferably, by mass%, Cu is more than 2.5% and less than 3.0%, and the alloy composition satisfies the following relations (1) and (2): 2.400 ≤ Cu + Ni + Ge ≤ 3.190 (1), and 0.33 ≤ Ge/Ni ≤ 1.04 (2). Cu, Ni, and Ge in the relations (1) and (2) each represent the contents (mass%) in the alloy composition.
Patent TW-202321290-A (TW)
Title: Engineered human fviii with enhanced secretion ability and clotting activity
Inventor: DONG BIAO
IPC: C07K14/755
Filed: 2022-08-29
Abstract: The present invention relates to an engineered human FVIII polypeptide, which includes at least two substituted amino acids in the A1 domain of hFVIII. In some embodiments, alternative amino acid positions include L50V and L152P. In some embodiments, alternative amino acids include one or more of D20S, G22L, I61T, D115E, F129I, G132D, Q139E, and L159F. The present invention also relates to a nucleic acid fragment encoding the engineered hFVIII polypeptide, an expression vector or a rAAV vector containing such nucleic acid fragment, and a method of using engineered hFVIII polypeptide to treat hemophilia A patients.