baber/WOPTO huggingface dataset:
Patent EP-1082307-B1 (EP)
Inventor: RAMASWAMY SOWMIANARAYANAN
IPC: C07D213/40
Filed: 1998-05-26
Granted: 2005-09-14
Abstract: A process for preparing  d-threo  methyl ±- piperid-2-ylarylacetates of formula III:   
wherein R 1  is aryl having 6 to 28 carbon atoms, comprising the steps of:  reacting a pyridine having formula I:     
wherein R 1  is aryl having 6 to 28 carbon atoms with hydrogen in an alkanoic acid having 1 to 10 carbon atoms and in the presence of a catalyst to provide a mixture of  threo  and  erythro  piperidine stereoisomers having formulas IIa-d:      
adding an alkyl alkanoate having 2 to 20 carbon atoms to said mixture, thereby precipitating alkanoate salts of said  erythro  stereoisomers preferentially with respect to alkanoate salts of said  threo  stereoisomers; 
reacting said  erythro  alkanoate salts with aqueous base to form said  erythro  stereoisomers; 
reacting said  erythro  stereoisomers with an acid resolving agent in an alkyl alcohol having 1 to 5 carbon atoms, thereby forming acid salts of said  1-erythro  stereoisomers preferentially with respect to said  d-erythro  stereoisomers; 
reacting said  1-erythro  acid salts with aqueous base to form said  1-erythro  piperidine; 
reacting said  1-erythro  piperidine with an alkali metal alkoxide having one to 10 carbon atoms in organic solvent, whereby forming said  d-threo  piperidine, and 
converting said  d-threo  piperidine to said  d-threo  methyl ±- piperid -2- ylarylacetate.
Patent EP-1017518-B1 (EP)
Inventor: PUETZ KARL HEINZ
IPC: B21H5/02
Filed: 1998-05-14
Granted: 2002-03-27
Abstract: The invention relates to a flowturning device (1; 101) for producing an internal geared wheel (17) with inner toothing, one set of which is slanted. The workpiece (9) is held by a retaining member (16; 116) during shaping of the first inner toothing. The workpiece (9) is held by the first toothing on the first shaping toot (2; 102) during shaping of the second inner toothing. Once the internal geared wheel (17) has been finished, the rotational coupling between both shaping tools (2, 4; 102, 104) is detached. The internal geared wheel (17) is detached from the slanted toothing(s) by means of a stripping member (18).
Patent EP-0998308-B1 (EP)
Inventor: WATSON ALAN
IPC: G01R33/28
Filed: 1998-07-01
Granted: 2007-12-19
Abstract: The invention provides a method of detecting myocardial ischemia in a human or a non-human body, said method comprising administering to said body a physiologically acceptable manganese complex or salt thereof, subjecting said body to a magnetic resonance imaging procedure capable of generating images with time intervals of less than 0.5 seconds and thereafter providing a series of images of the myocardium of said body whereby to identify regions of abnormal blood flow. The method in accordance with the invention is of use not only in detecting myocardial ischemia, but also in discriminating between reversibly and irreversibly injured myocardial tissues, thereby providing important information about myocardial viability, e.g. during or following a severe heart attack or coronary occlusion. The method of the invention also provides an effective means of monitoring reperfusion of the myocardium.
Patent EP-1008161-B1 (EP)
Inventor: DHULER VIJAYAKUMAR R
IPC: F03G7/06
Filed: 1998-08-28
Granted: 2002-07-10
Abstract: A MEMS actuator is provided that produces significant forces and displacements while consuming a reasonable amount of power. The MEMS actuator includes a microelectronic substrate, spaced apart supports on the substrate and a metallic arched beam extending between the spaced apart supports. The MEMS actuator also includes a heater for heating the arched beam to cause further arching of the beam. In order to effectively transfer heat from the heater to the metallic arched beam, the metallic arched beam extends over and is spaced, albeit slightly, from the heater. As such, the MEMS actuator effectively converts the heat generated by the heater into mechanical motion of the metallic arched beam. A family of other MEMS devices, such as relays, switching arrays and valves, are also provided that include one or more MEMS actuators in order to take advantage of its efficient operating characteristics. In addition, a method of fabricating a MEMS actuator is further provided.
Patent EP-1017817-B1 (EP)
Inventor: WEINTRAUB BRUCE D
IPC: C12N15/16
Filed: 1998-09-22
Granted: 2007-03-07
Abstract: The present invention is based upon the discovery that mutant ± subunits and mutant ² subunits each comprising amino acid substitutions relative to the wild type can be produced and assembled to form a mutant TSH heterodimer or TSH analog that possesses higher bioactivity  in vitro  and longer half life  in vivo.  Accordingly, the present invention provides methods for using mutant TSH heterodimers, TSH analogs, fragments, and derivatives thereof for treating or preventing diseases of the thyroid, in particular thyroid cancer. The invention also relates to methods of diagnosis, prognosis and monitoring for thyroid-related functions. Pharmaceutical and diagnostic compositions, methods of using mutant TSH heterodimers and TSH analogs with utility for treatment and prevention of metabolic and reproductive diseases are also provided.
Patent EP-1035780-B1 (EP)
Inventor: WALLEN ERIK S
IPC: A61K38/00
Filed: 1998-12-04
Granted: 2007-02-14
Abstract: The present invention provides a method for synthesizing heat shock protein-peptide complexes comprising the steps of: adding a shock protein to a denatured protein matrix to bind the heat shock protein to the denatured protein matrix; and adding a complexing solution comprising a peptide to elute a heat shock protein-peptide complex. The present invention also provides a heat shock protein-peptide complex synthesized by the method of the invention. In addition the present invention provides an apparatus for synthesizing heat shock protein-peptide complexes comprising a heat shock protein complex bound to a denatured protein matrix. The present invention also provides a method for treating an allergic disease in which a heat shock protein-antigen complex is administered to a mammal in an amount sufficient to reduce the susceptibility of the mammal to a Th2 response for the allergic disease. The method of the present invention can be used either to prevent an invididual from having an allergic reaction to an allergic disease or to reduce the effects of an allergic disease in an individual already suffering from the allergic disease.
Patent EP-0951109-B1 (EP)
Inventor: HENRICI DIETER DIPL-ING
IPC: H01R13/506
Filed: 1999-04-06
Granted: 2007-02-28
Abstract: The base section (26a-c) and head (25) of the socket are constructed as separate components. The plastic push-in section (30) for the head is integral with its base. Head and base section snap- and interlock together. Guide surfaces for the conductor terminations, extend from base walls to the insertion opening of the push-in section.
Patent EP-0995576-B1 (EP)
Inventor: HERBST RICHARD
IPC: B29C45/14
Filed: 1999-09-24
Granted: 2002-07-24
Abstract: PROBLEM TO BE SOLVED: To reduce the transmission of the vibration of an injection molding machine to a handling apparatus. SOLUTION: A plastic injection molding equipment has a plastic injection molding machine 12 and a handling apparatus 14 for supplying a molded product and/or an accessory product to the plastic molding machine and/or taking out the same therefrom and the injection molding machine 12 has a first stand 24 and at least one of movable mold half parts 16, 18 movable along a first moving direction 22 relatively with respect to the first stand 24 and the handling apparatus 14 has a second stand 58 and the stands 24, 58 are mutually connected through connection elements 34, 66. Both stands 24, 58 are connected so as to be relatively movable along at least one first axial line (x). A plastic product is subjected to injection molding by this plastic injection molding equipment 10.
Patent EP-1004439-B1 (EP)
Inventor: HEILER PETER
IPC: B41F30/04
Filed: 1999-11-04
Granted: 2003-06-04
Abstract: A device for positioning and tensioning a cylinder dressing on a printing-machine cylinder, wherein both a leading dressing end and a trailing dressing end of the cylinder dressing are tensioned, includes, in a first step, tensioning both dressing ends, and in a second step, relieving the tension in a first of the two dressing ends, while retensioning a second of the dressing ends; and a printing machine provided with the device.
Patent EP-1013822-B1 (EP)
Inventor: WESTERKAMP ARVED H DIPL-ING
IPC: D21F1/00
Filed: 1999-12-04
Granted: 2005-03-02
Abstract: The fourdrinier, for the wet section of a papermaking machine, is a textile or non-textile and especially a woven material (16), with a nonwoven layer (20) which at least partially covers the side (18) towards the paper. The nonwoven layer is compressed less strongly in some zones than in other zones. The nonwoven layer (20) is less compressed at zones where the fourdrinier surface (18) towards the paper has raised sections. The nonwoven layer has a thickness of 0.1-1.0 mm, with a consistent permeability. The outer surface (21) of the nonwoven layer (20) can have a durable structure with profiles such as in circles, triangles, rectangles or similar recessed profiles. The surface (21) of the nonwoven layer (20) is treated physically/chemically to give qualities such as hydrophobic, hydrophilic, antistatic or dirt resistant. The nonwoven layer (20) has pores through it which pref. taper or expand downwards towards the fourdrinier material (16). The surface (18) of the fourdrinier material (16) towards the paper has fibers or filaments which give a durable bond with the nonwoven layer (20). The nonwoven layer contains a bonding agent pref. as a fusible adhesive for bonding to the fourdrinier, to be activated by a linear pressure of 10-50 N/mm and heat at a temp. of 170-270 degrees C. Or the nonwoven (20) is durably bonded to the fourdrinier (16) by ultrasonics with a welding frequency of 15-72 MHz and pref. 15-35MHz. The nonwoven layer (20) covers ≥ 40% of the surface (18) of the fourdrinier (16) towards the paper.
Patent EP-0982239-B1 (EP)
Inventor: THORNSEN HANS ERIK
IPC: B65D88/22
Filed: 1999-08-24
Granted: 2004-03-24
Abstract: The invention relates to a collapsible container liner comprising side walls defining an interior space     said liner having an upper and a lower portion, at least one of said walls (15) comprising an opening communicating with at least one discharge tube (14) being incorporated in the lower portion of said liner, said discharge tube or discharge tubes (14) being fitted with releasable sealing means (114), said sealing means being accessible and releasable from the outside of said discharge tube, said sealing means surrounding and tightening said discharge tube in its closed position, said sealing means providing access to the interior of the liner when released. A simple release of the releasable sealing means blocking the discharge tube provides an opening of the liner, which results in no physical contact with the interior of the container, as the discharge tube communicates with an opening of the interior of the container <IMAGE>
Patent EP-0928792-B1 (EP)
Inventor: CHENARD BERTRAND LEO
IPC: A61K31/40
Filed: 1999-01-06
Granted: 2006-04-19
Abstract: The present invention relates to compounds of the formula I, as defined in the specification, pharmaceutical compositions containing such compounds the use of such compounds to treat neurological and psychiatric disorders.
Patent EP-0993840-B1 (EP)
Inventor: OLLIVIER JEAN-FRANCOIS
IPC: A61N1/39
Filed: 1999-10-13
Granted: 2009-04-22
Abstract: The end (34) of the probe auto-orientates, and the electrode is of a sector type with a lateral part extending in a radial plane only within one sector of the probe. Device comprises a probe body with an elastically deformable hollow casing, the end (34) of which holds a stimulation electrode (54). A detachable mandrel can be introduced into the hollow body and moved within the hollow tube with the mandrel relatively rigid compared with hollow tube. It is also locally plastically deformable. The end (34) of the probe naturally forms two distinct curves that are formed on each of its surfaces. A first surface (62) corresponds to one orientation curve, and a second surface (64) corresponds to a pressure surface.
Patent EP-1017136-B1 (EP)
Inventor: ANNALER JACQUES
IPC: H01R13/24
Filed: 1999-12-09
Granted: 2002-09-11
Abstract: In order to increase the precision in the definition of a contact by pressure between a connector (1), designed to be surface-mounted, and a chip card, the connector is provided with a support plane on a plane printed circuit. This support plane is obtained by means of prestresses obtained on conductive elastic tabs (3-8) of the connector. This prestress consists in placing one end (11-13) of the conductive elastic tabs against stops (14-17) aligned in a plane. This improvement induces an ease of implementation of a connector of this kind as well as the possibility of having a statistical control of the quality of the connectors thus made. <IMAGE>
Patent EP-1053419-B1 (EP)
Inventor: RADELET CHRISTIAAN
IPC: H05K5/06
Filed: 1999-01-26
Granted: 2003-04-16
Abstract: A sealing arrangement is provided including a first housing and a second housing and a sealing member positioned therebetween. In various embodiments, one housing includes a channel shaped portion and the other housing includes a tongue shaped portion movable in an axial direction into the channel shaped portion to compress the sealing member therebetween in a transverse direction relative to the axial direction. In further embodiments, both housings include a channel shaped portion and the sealing member extends into each channel shaped portion and is compressed within each channel shaped portion in a transverse direction.
Patent EP-1056487-B1 (EP)
Inventor: LANGER ROBERT S
IPC: A61L31/14
Filed: 1999-02-23
Granted: 2004-05-12
Abstract: Biodegradable shape memory polymer compositions, articles of manufacture thereof, and methods of preparation and use thereof are described. In one embodiment the compositions include at least one hard segment and at least one soft segment. The Ttrans of the hard segment is preferably between -30 and 270 DEG  C. At least one of the hard or soft segments can contain a crosslinkable group, and the segments can be linked by formation of an interpenetrating network or a semi-interpenetrating network, or by physical interactions of the segments. Objects can be formed into a given shape at a temperature above the Ttrans of the hard segment, and cooled to a temperature below the Ttrans of the soft segment. If the object is subsequently formed into a second shape, the object can return to its original shape by heating the object above the Ttrans of the soft segment and below the Ttrans of the hard segment.
Patent EP-1068251-B1 (EP)
Inventor: GREGORY PETER
IPC: C09D11/00
Filed: 1999-03-25
Granted: 2005-10-19
Abstract: The invention relates to polyurethanes, inks comprising polyurethanes and their use in ink jet printing where the polyurethane comprises a colored water-dissipatable polyurethane obtainable from the reaction of a polyisocyanate, a compound providing water-dispersing groups and a colorant having at least two functional groups.</PTEXT>
Patent EP-1063925-B1 (EP)
Inventor: BAGLEY DEMETRIUS H
IPC: A61B17/22
Filed: 1999-03-19
Granted: 2004-07-21
Abstract: A minimally invasive medical retrieval device 10 useful for the removal of objects such as stones, calculi, concretions, foreign bodies and the like from the urinary, biliary, vascular or other systems includes a sheath 12 containing at least three wires 14 adjacently disposed in the sheath 12. At least one of the wires 14, and preferably all of them, can be moved longitudinally with respect to the sheath 12. The wires 14 have distal portions 16 which are formed so as to allow the engaging and removal of the object or objects. The distal portions 16 of the wires 14 preferably form a helical basket 22 or 40 particularly adapted for engaging urinary stones, calculi and concretions. Other grasping and manipulating shapes are useful as well. The wires 14 are substantially wedge-shaped in cross-section and substantially fill the entire cross-sectional area of the interior 26 of the sheath 12. The wedge-shaped wires 14 can be partly contained within a stainless steel cannula 28 positioned in the sheath 12. The sheath 12 can be of very small diameter, significantly smaller than the diameters of existing retrieval or extraction devices, preferably from about 0.5 to about 6.0 French. Unexpectedly, despite these small diameters, the baskets, graspers and the like into which the wedge-shaped wires 14 are formed simultaneously exhibit good resistance to twisting and bending, while being capable of being formed into shapes (such as helical baskets) not normally achieved with flat wires.
Patent EP-1091912-B1 (EP)
Inventor: DI GIUSEPPANTONIO VINCENZO
IPC: C03B11/14
Filed: 1999-04-19
Granted: 2002-12-11
Abstract: The invention relates to the sector of methods for automatically obtaining containers with a precision mouth and with a base and/or body surrounded totally or partially by glass decorations of the same or a different colour. The method comprises combining a process performed with an I.S. machine with a pressing or injection process by means of a transferring method for moving and for displacing the container from the I.S. machine into the pressing or injection machine. The container comprises a precision mouth and an external glass decoration which surrounds totally or partially the base of the container itself.
Patent EP-1084133-B1 (EP)
Inventor: BUCK HARVEY B JR
IPC: G01N33/536
Filed: 1999-05-28
Granted: 2002-08-28
Abstract: A method and device for detection and quantification of biologically significant analytes in a liquid sample is described. The method includes contacting a volume of a liquid sample with predetermined amounts of at least a first and second redox reversible species having redox potentials differing by at least 50 millivolts. At least one of the redox reversible species comprises a liquid sample diffusible conjugate of a ligand analog of an analyte in the liquid sample and a redox reversible label. A predetermined amount of at least one specific binding partner for each analyte to be measured is combined with the sample and current flow is measured at first and second anodic and cathodic potentials and correlated with current flows for known concentrations of the respective diffusible redox reversible species. Diagnostic devices and kits, including such devices and the specified specific binding partner(s) and redox reversible species are also described.
Patent EP-1086570-B1 (EP)
Title: Systeme de messagerie universelle
Inventor: LUZESKI NICHOLAS M
IPC: H04M7/00
Filed: 1999-06-03
Granted: 2002-09-04
Abstract: Un système de messagerie universelle offre des services de messagerie électronique, de messagerie vocale et de messagerie de télécopie à des abonnés qui peuvent utiliser le réseau Internet (16) pour accéder à leurs messages. Le système comprend un système de messagerie électronique associé à un système de messagerie vocale/télécopie située sur un ordinateur (10) de plate-forme de messagerie. Les messages de courrier électronique sont stockés dans une mémoire (10-2) de messages de courrier électronique, et les messages de boîte vocale et/ou de télécopie sont stockés dans une mémoire séparée (10-9) contrôlée par exemple par un gestionnaire (10-8) de messages de boîte vocale. Les abonnés peuvent accéder à leurs messages à partir d'un ordinateur personnel (20) via le réseau Internet (16) à l'aide d'un explorateur Web standard (22) au moyen d'une mini-application (22A, 22B, à 22N) qui présente à chaque abonné une ''boîte universelle'' qui affiche tous les messages électroniques, de télécopie et de boîte vocale de l'abonné. Une plate-forme Web (12) commande l'interface (22) d'explorateur Web associée à la plate-forme (10) de messagerie, accepte les demandes provenant de l'explorateur Web (telle qu'une demande de lecture d'un courrier électronique ou d'écoute d'un message vocal) et renvoie à l'explorateur Web les types d'information déterminés. La plate-forme Web est reliée à la plate-forme de messagerie via une interface/routeur (10-6) générique TCP/IP. Une application (10-5) de gestionnaire de sessions gère la ''session'' de l'explorateur Web avec le système de messagerie. Une couche (10-4) d'appels de messagerie commune (AMC) située dans la plate-forme de messagerie assure la liaison qui permet la communication et la commande entre les différentes mémoires de messages et parmi ces dernières. La couche AMC utilise un mécanisme standard pour réaliser une interface API standard à l'aide de laquelle on peut accéder à des mémoires de messages privés.
Patent EP-1060091-B1 (EP)
Inventor: CAVALLINI FRANCESCO
IPC: B60L3/00
Filed: 1999-01-27
Granted: 2004-01-14
Abstract: An automatic cart for transporting golf clubs or other objects and accessories. The cart has at least one electric drive motor connected to at least one wheel of the cart, at least one electronic controller for controlling the motor, and a plurality of sensors peripherally disposed on the cart. The sensors are used to detect the presence of obstacles in the path of the cart and to sense the signals coming from an external signal source associated with the user. A microcomputer control unit analyses information from the sensors and coordinates movement of the cart so that it stays near the user.
Patent EP-1060023-B1 (EP)
Inventor: DUBROW ROBERT S
IPC: B01L3/00
Filed: 1999-02-23
Granted: 2012-05-09
Abstract: The present invention provides microfluidic devices that comprise a body structure (100) comprising at least a first microscale channel network (114) disposed therein. The body structure (100) has a plurality of ports (106) disposed in the body structure (100), where each port (106) is in fluid communication with one or more channels (114) in the first channel network. The devices also include a cover layer (200) comprising a plurality of apertures (206) disposed through the cover layer (200). The cover layer (200) is mated with the body structure (100) whereby each of the apertures (206) is aligned with a separate one of the plurality of ports (106).
Patent EP-1025846-B1 (EP)
Inventor: YASUEDA SHINICHI
IPC: A61K9/08
Filed: 1999-08-20
Granted: 2006-07-12
Abstract: Aqueous liquid preparations containing gatifloxacin (chemical name: (+/-)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piper azinyl)-4-oxo-quinolinecarboxylic acid) or its salt and sodium edetate; and a method for enhancing the corneal permeability of gatifloxacin, a method for preventing crystallization of gatifloxacin and a method for preventing coloration of gatifloxacin each by blending gatifloxacin or its salt with sodium edetate.
Patent EP-1105622-B1 (EP)
Inventor: DIBELLA JOSEPH
IPC: F01D17/16
Filed: 1999-08-04
Granted: 2004-12-01
Abstract: A variable stator vane (14) includes an airfoil having a threaded stem (20), a lever (22) having a mounting hole (28) receiving the stem (20) and a nut (24) threadingly engaging the stem (20) to retain the lever on the airfoil (14). A clearance is provided between the seat and lever (22) during alignment therebetween to provide sufficient thread overlap between the nut and stem to permit engagement therebetween, with insufficient thread overlap being provided during misalignment to prevent threaded engagement therebetween.