Patent GB-449468-A (GB)
Title: Process for the production of a product containing magnesium for therapeutic purposes and industrial purposes
IPC: A61K36/00
Filed: 1934-11-19
Abstract: Organic halogen compounds are incorporated into plants containing chlorophyll, and a complex containing a colloidal organic magnesium halogen compound extracted therefrom.  Parts of plants such as stems, leaves, and needles may be treated and the whole or part of the plant used for the extraction.  Plants with strongly developed parenchyme such as cacti, aloes, and agavae are preferred especially those exhibiting coloured markings such as the aucuba thunb.  Organic bromine compounds, especially the lower aliphatic compounds such as ethylene bromide, brominated alcohols, aldehydes ketones, and carboxylic acids may be used, in particular ethylene bromhydrin and tribromethyl alcohol.  Aqueous solutions may be employed with the addition, if necessary, of solvents, in particular glucuronic acid. The halogen compounds are incorporated in the plant by addition to the culture medium in solid form, alone or mixed with fertilizers, by watering, dusting, or spraying, by respiration in an atmosphere containing a gaseous compound or by injection as with an injection syringe.  The complex formed can be extracted with distilled water or solutions of suitable osmotic pressure which cause swelling or shrinking of the plant cells, the temperature being kept below 50 DEG C.  Phenols or other sterilizing agents may be added to the extraction liquid, and the plants previously washed and sterilized. Alternatively, the plants may be tapped or the complex withdrawn by means of an injection syringe.  In some cases anomalies of growth such as cysts form on the plants, these being enriched in the complex.  An aucuba thunb, having a rising sap stream is watered in the absence of sunlight with an aqueous solution containing 3 c.c. ethylene bromhydrin per litre, 300 c.c. being used every other day. After 3--4 weeks a brown colouration of the plant indicates formation of the complex.  The leaves are cut off, sterilized with carbolic acid solution, cut into strips, drained, and 30 g. extracted with 1 litre of 0,5 per cent sodium chloride solution containing 0,5 per cent phenol, usually for 36 hours.  By using larger amounts of leaf and of sodium chloride, the colloidal complex is precipitated.  The product can convert carbonic acid into formaldehyde and polymerize aldehydes to higher complexes.ALSO:Organic halogen compounds are incorporated into plants containing chlorophyll, and a complex containing a colloidal organic magnesium halogen compound extracted therefrom.  Parts of plants such as stems, leaves, and needles may be treated and the whole or part of the plant used for the extraction. Plants with strongly developed parenchyme such as cacti, aloes, and agav  are preferred especially those exhibiting coloured markings such as the aucuba thunb.  Organic bromine compounds, especially the lower aliphatic compounds such as ethylene bromide, brominated alcohols, aldehydes, ketones, and carboxylic acids may be used, in particular ethylene bromhydrin and tribromethyl alcohol.  Aqueous solutions may be employed with the addition, if necessary, of solvents, in particular glucuronic acid.  The halogen compounds are incorporated in the plant by addition to the culture medium in solid form, alone or mixed with fertilizers, by watering, dusting, or spraying, by respiration in an atmosphere containing a gaseous compound or by injection as with an injection syringe.  The complex formed can be extracted with distilled water or solutions of suitable osmotic pressure which cause swelling or shrinking of the plant cells, the temperature being kept below 50 DEG  C. Alternatively the plants may be tapped or the complex withdrawn by means of an injection syringe.  In some cases anomalies of growth such as cysts form on the plants, these being enriched in the complex.  An aucuba thunb, having a rising sap stream is watered in the absence of sunlight with an aqueous solution containing 3 c.c. ethylene bromhydrin per litre, 300 c.c. being used every other day.  After 3--4 weeks a brown colouration of the plant indicates formation of the complex.  The leaves are cut off, sterilized with carbolic acid solution, cut into strips, drained, and 30 g. extracted with 1 litre of 0,5 per cent sodium chloride solution containing 0,5 per cent phenol, usually for 36 hours. By using larger amounts of leaf and of sodium chloride, the colloidal complex is precipitated.  The product can convert carbonic acid into formaldehyde and polymerize aldehydes to higher complexes.ALSO:Organic halogen compounds are incorporated into plants containing chlorophyll, and a complex containing a colloidal organic magnesium halogen compound extracted therefrom. Parts of plants such as stems, leaves, and needles may be treated and the whole or part of the plant used for the extraction.  Plants with strongly developed parenchyme such as cacti, aloes, and agavae are preferred, especially those exhibiting coloured markings such as the aucuba thunb.  Organic bromine compounds, especially the lower aliphatic compounds such as ethylene bromide, brominated alcohols, aldehydes, ketones, and carboxylic acids may be used, in particular ethylene bromhydrin and tribrom-ethyl alcohol.  Aqueous solutions may be employed with the addition, if necessary, of solvents, in particular glucuronic acid.  The halogen compounds are incorporated in the plant by addition to the culture medium in solid form, alone or mixed with fertilizers, by watering, dusting, or spraying, by respiration in an atmosphere containing a gaseous compound, or by injection as with an injection syringe.  The complex formed can be extracted with distilled water or solutions of suitable osmotic pressure which cause swelling or shrinking of the plant cells, the temperature being kept below 50 DEG  C.  Phenols or other sterilizing agents may be added to the extraction liquid, and the plants previously washed and sterilized. Alternatively, the plants may be tapped or the complex withdrawn by means of an injection syringe.  In some cases anomalies of growth such as cysts form on the plants, these being enriched in the complex.  An aucuba thunb. having a rising sap stream is watered in the absence of sunlight with an aqueous solution containing 3 c.c. ethylene bromhydrin per litre, 300 c.c. being used every other day.  After 3-4 weeks a brown colouration of the plant indicates formation of the complex.  The leaves are cut off, sterilized with carbolic acid solution, cut into strips, drained, and 30 g. extracted with 1 litre of 0,5 per cent sodium chloride solution containing 0,5 per cent phenol, usually for 36 hrs. After filtering and standing for 4 weeks, the solution is ready for use by injection in the treatment of diseases connected with metabolism such as carcinoma.  By using larger amounts of leaf and of sodium chloride, the colloidal complex is precipitated and is used for suppositories and ointments.  The product can convert carbonic acid into formaldehyde and polymerize aldehydes to higher complexes.