Patent EP-1978023-A1 (EP)
Inventor: GAERTZEN OLIVER
IPC: C07D405/14
Filed: 2007-04-04
Abstract: Pyridazine compounds (I) and their salts are new. Pyridazine compounds of formula (I) and their salts are new. R1>H, 1-8C alkyl, 2-8C alkenyl, 2-8C alklnyl, 3-8C cycloalkyl, 3-8C cycloalkenyl or 3-10 membered saturated, mono- or bicyclic carbon bound heterocycle containing up to four heteroatoms including O, N or S, where the two oxygen atoms are non-adjacent and R1> is substituted by 1-3 groups of R5>; R2>1-6C alkoxy, 2-6C alkenyloxy, 2-6C alklnyloxy, 3-8C cycloalkyloxy, 1-6C alkylthio, 1-6C alkylsulfinyl, 1-6C alkylsulfonyl, 1-6C haloalkoxy or 1-6C haloalkylthio, 1-6C trialkylsilyl (all substituted by 1-3 groups of R5>), halo or CN; R3>, R4>5-7 membered unsaturated heterocycle with up to four heteroatoms including N, O or S, where the two oxygen atoms are non-adjacent, optionally annealed with a 5-6 membered optionally saturated carbocyclic or heterocyclic ring, where the heterocyclic ring contains up to two additional heteroatoms including N, O or S, where the two oxygen atoms are non-adjacent, R3> is homogeneous or differently substituted by R6> and R4> is homogeneous or differently by R7>; R5>halo, 1-6C alkylamino, 1-6C dialkylamino, 1-6C alkylhydrazino, CN, oxo, nitro, 1-6C alkylthio, 1-6C alkyl, 1-6C halo, tri(1-4C alkyl)silyl and/or 1-6C alkoxy, and/or 3-6C cycloalkyl (optionally substituted by halo, 1-4C alkyl or 1-4C haloalkyl); and either R6>, R7>H, halo, CN, nitro, amino, OH, mercapto, formyl, carboxy, carbamoyl, thiocarbamoyl, 1-6C alkyl, 1-6C alkoxy, 1-6C alkylthio, 1-6C alkylsulfinyl or 1-6C alkylsulfonyl, 2-6C alkenyl or 2-6C alkenyloxy, 2-6C alkynyl or 2-6C alkynyloxy, 1-6C haloalkyl, 1-6C haloalkoxy, 1-6C haloalkylthio, 1-6C haloalkylsulfinyl or 1-6C haloalkylsulfonyl with 1-13 halo atoms, 2-6C haloalkenyl or 2-6C haloalkenyloxy with 1-11 haloatom or 2-6C haloalkynyloxy, 1-6C alkylamino, 1-6C alkylcarbonyl, 1-6C alkylcarbonyloxy, 1-6C alkylcarbonylamino, 1-6C alkoxycarbonyl, 1-6C alkoxy-carbonyloxy, 1-6C alkoxycarbonylamino, 1-6C alkylaminocarbonyl, 1-6C alkylamino-carbonyloxy, 1-6C alkylaminosulfonyl, 1-6C alkylsulfonylamino, 1-6C alkylsulfonyloxy, hydroxyimino-1-6C alkyl or 1-6C alkoximino-1-6C alkyl, 3-8C cycloalkylamino (optionally partially substituted alkyl), 3-8C cycloalkylaminocarbonyl, 3-8C cycloalkylaminocarbonyloxy, 1-6C alkoxy-1-6C alkyl, 1-6C haloalkoxy-1-6C alkyl, 1-6C alkylamino-1-6C alkyl, 1-6C alkoxy-1-6C alkoxy, 1-6C alkoxy-1-6C alkoxy-1-6C alkoxy, 1-6C haloalkoxy-1-6C alkoxy, 1-6C alkylamino-1-6C alkoxy, dialkylamino, dialkylaminoalkyl, dialkylaminoalkoxy, dialkylaminocarbonyl, 1-6C dialkylaminosulfonyl or 1-6C dialkylaminocarbonyloxy in the single separated alkyl, optionally up to five fold substituted 3-8C cycloalkyl, where the substituents are F, Cl, methyl, cyclopropyl or trifluoromethyl, optionally up to five fold substituted phenyl, where the substituent is F, Cl, methyl, trifluoromethyl, N-methoxyethane imidoyl, (methoxyimino) methyl, optionally substituted and saturated 5-7 membered heterocycle with up to four heteroatom including N, O or S, where the two oxygen atoms are non-adjacent and the substituents include F, Cl, methyl, trifluoromethyl, N-methoxyethane imidoyl, (methoxyimino)methyl; or C+R6>R7>carbonyl- or thiocarbonyl group. Independent claims are included for: (1) an agent to combat undesirable microorganism comprising (I), diluent, surface active materials and/or carrier materials; (2) the preparation of (I); (3) a hydroxylactone compound of formula (VII); and (4) a 2H-pyridazin-3-one compound of formula (VIII). [Image] [Image] ACTIVITY : Antibacterial; Fungicide; Antialgal. MECHANISM OF ACTION : None given.