baber/WOPTO huggingface dataset:
Patent PT-784429-E (PT)
Inventor: KAESEMEYER WAYNE H
IPC: A61K38/095
Filed: 1995-10-05
Abstract: A therapeutic mixture comprising a mixture of a venous dilator, selected from isosorbide dinitrate and isosorbide 5'-mononitrate, and an arterial dilator such as L-arginine, is disclosed for the treatment of diseases related to vasoconstriction, wherein the vasoconstriction is relieved by stimulating the constitutive form of nitric oxide synthase (cNOS) to produce native nitric oxide (NO). The native NO having superior beneficial effect when compared to exogenous NO produced by a L-arginine independent pathway in terms of the ability to reduce clinical endpoints and mortality.
Patent PT-733614-E (PT)
Inventor: FORAT GERARD
IPC: C07C49/613
Filed: 1996-03-22
Abstract: Nucleophilic reactant used for grafting a substd. difluoromethyl gp. onto an electrophilic cpd., comprises: (a) a fluorocarboxylic acid of formula Ea-CF2-COOH where Ea is electron-attracting atom or gp. at least partially salted by organic or mineral cation; and (b) a polar aprotic solvent. The content of potentially-free portions present in different components (i.e. impurities) is at most, equal to half initial molar concn. of the fluorocarboxylic acid. Also claimed is the method of synthesis of a deriv. incorporating the difluoromethylene gp. comprising: (i) reacting an electrophilic cpd. with the above reagent; and (ii) heating the mixt. at 100-200 deg.C for 1/2 hr. to one day.
Patent PT-827449-E (PT)
Inventor: HART COLIN R
IPC: B31B19/98
Filed: 1996-05-13
Abstract: Apparatus for automatically removing bags from a supply conveyor and stacking a predetermined number of bags upon raised pins. The stacks are then placed on a stack transfer assembly that is then moved into a transfer station wherein the stacks are placed on wickets. An endless accumulator conveyor is arranged to deliver the wickets into the transfer station in timed relation with the movement of the transfer assembly between stations.
Patent PT-795183-E (PT)
Inventor: MAGNIER PHILIPPE
IPC: H01F27/14
Filed: 1996-09-27
Abstract: PCT No. PCT/FR96/01513 Sec. 371 Date May 19, 1997 Sec. 102(e) Date May 19, 1997 PCT Filed Sep. 27, 1996 PCT Pub. No. WO97/12379 PCT Pub. Date Apr. 3, 1997An electrical transformer which is filled with a combustible coolant may experience a break in the electrical insulation within the transformer. This break in the electrical insulation may lead to an explosion or fire. A pressure sensor and a vapor sensor are preferably coupled to the enclosure to monitor the pressure and vapor content of the enclosure. An increase in pressure of the enclosure may indicate that an insulation breakdown has occurred. When an increase in pressure is detected, the coolant is partially drained from the enclosure. After draining some of the coolant, an inert gas may be injected into the bottom of the enclosure to stir the remaining coolant.
Patent PT-887159-E (PT)
Inventor: WALLACE MARCUS T
IPC: B23D45/12
Filed: 1998-06-04
Abstract: The present invention discloses a roll cutter. The roll cutter has a housing (12) to which there is attached a platform (20), an adjustable cutter assembly (34), and an adjustable hoist assembly (50). The hoist assembly is mounted on a telescoping tower (60) allowing the user to engage a roll (100) and move it onto the platform (20). The cutter assembly (34) having a cutting tower (30), a cutting arm (32), and a saw blade (48) can be placed at the desired level of cut. The saw blade (48) can then but away toll to the desired width. A sanding blade can be used to sand the end face of the roll. <IMAGE>
Patent PT-887350-E (PT)
Inventor: LAVIELLE GILBERT
IPC: C07D491/052
Filed: 1998-06-23
Abstract: Hexahydro-chromeno-Ä3,4-cÜ-pyrrole derivatives of formula (I), their enantiomers, diastereoisomers and salts are new. m = 0-3; n = 0-3; n+m = 2 or 3; p = 1-6; the junction between rings B and C is trans; X = CN or -CONR4R5; R4, R5 = H, 1-6C alkyl, 3-7C cycloalkyl or optionally substituted aryl; A = sigma bond or -NR-CO-, -CO-NR-, -NR-SO2-, or -SO2-NR-; R = H or 1-6C alkyl; R1, R2 = H or 1-6C alkyl; R3 = H or phenyl, naphthyl or heteroaryl (all optionally substituted by one or more halo, 1-6C alkyl or alkoxy, OH, CN, NH2, NO2, COOH, 1-6C perhaloalkyl, sulphonyl, acylamino, 1-6C alkylsulphonyl, or 1-6C alkyl sulphonylamino), aryl or heteroaryl (both substituted by A'-Cy), 2-indolinon-5-yl, or, when A is a sigma bond, aryloxy or arylthio; A' = sigma bond or 1-6C alkylene or alkenylene, (in which one C atom may be replaced by O or S), -NR-CO-, -CO-NR-, -NR-SO2-, or -SO2-NR-; Cy = aryl or heteroaryl (optionally substituted); provided that when n = 0, then m is other than 2, when n = 1, R1, R2 = H, A = sigma bond and p = 1, then R3 is not phenyl nor pyridyl, when n = 1, R1 & R2 = H, A = sigma bond, R3 is not H, when n = 1, R1 & R2 = H, A = -NH-CO-, then R3 is other than H, phenyl, naphthyl, thienyl, furyl, pyrrolyl, pyridyl, (all optionally substituted by one or more halo, trihalomethyl, alkoxy or OH).
Patent PT-950640-E (PT)
Inventor: BASSE HARTWIG
IPC: C02F3/10
Filed: 1999-03-10
Abstract: In a biological water treatment process, water flows over hanging strands which serve as the substrate on which colonies of micro- organisms grow. Each strand (19,24) hangs over and either side of an overhead beam (23), to which it is attached. The strand center section is lashed down by a cord (21).
Patent PT-1070022-E (PT)
Inventor: LEBECH FINN
IPC: C02F1/74
Filed: 1999-03-30
Abstract: The invention relates to treatment of water, comprising initiating formation of drops from an introduced amount of water and division of the formed drops to form microdrops preferably by division at least 50-60 times. The invention also relates to an apparatus for performing the invention.
Patent PT-1097066-E (PT)
Inventor: MARES FRANK
IPC: B60R22/12
Filed: 1999-06-15
Abstract: The present webbing has a force-displacement profile characterized by: (a) when the webbing is subjected to a knuckle point force in the range from about 400 pounds (about 1.8 kilonewtons) to about 900 pounds (about 4.0 kilonewtons), the webbing elongates to less than about five percent; (b) upon subjecting the webbing to greater than the knuckle point force and to less or equal to about 1,400 pounds (about 6.2 kilonewtons), the webbing elongates further to at least about ten percent; and (c) upon subjecting the webbing to greater than 1,400 pounds (about 6.2 kilonewtons), the modulus increases sharply and the webbing elongates further until the webbing breaks at a tensile strength of at least about 5,000 pounds (about 22 kilonewtons). The present webbing is useful for seat belts, parachute harnesses and lines, shoulder harnesses, cargo handling, safety nets, trampolines, safety belts or harnesses for workers at high attitudes, military arrestor tapes for slowing aircraft, ski tow lines, and in cordage applications such as for yacht mooring or oil derrick mooring.
Patent IE-900074-L (IE)
Title: Anti-inflammatory 1-heteroaryloxindole-3-carboxamides
IPC: C07D409/14
Filed: 1990-01-09
Abstract: Indole derivs. of formula (I), their pharmaceutically acceptable salts and prodrugs are new: R1 = thienyl, furyl or 2-thiazolyl; R2 = thienyl, furyl or 2-X-4-Y- phenyl; X = H, F, Cl, 1-4C alkyl, 1-4C alkoxy, 1-4C alkylthio, NO2 or CF3; Y = H, F or Cl; R3 and R4 = H, F, Cl, Br, 1-4C alkyl, 1-4C alkoxy, 1-4C alkylthio, NO2 or CF3. - Pref. R1 = thienyl or furyl (esp. 2- or 3-thienyl or 3-furyl); R2 = 2-X-4-Y-phenyl; and prodrugs are of formula (II) are also claimed. R5 = alkanoyl, cycloalkanoyl, phenylalkanoyl, chlorobenzoyl, methoxybenzyl, Ph, thenoyl, omega-alkoxycarbonyl alkanoyl, alkoxycarbonyl, phenoxycarbonyl, 1-alkoxyalkyl, 1-alkoxycarbonyloxy alkyl, alkyl, alkylsulphonyl, methylphenylsulphonyl or dialkylphosphonate.
Patent IE-810187-L (IE)
Title: Stabilized oral composition
IPC: A61K8/73
Filed: 1981-01-30
Abstract: An oral composition containing an oral vehicle, tranexamic acid as antigingivitis agent, a fluorine-containing anticaries agent, and a flavor mixture of methyl salicyclate, menthol, eugenol and cineol.
[US4272513A]
Patent IE-42112-L (IE)
Title: 2-BROMO-6ß-FLUOROPREGNA-1,4-DIENE-3,20-DIONES
IPC: A61P29/00
Filed: 1975-02-24
Abstract: 1499822 2 - Bromo - 6# - fluoropregna- 1,4-diene-3,20-diones PIERREL SpA 6 Feb 1975 [27 Feb 1974 5 July 1974 25 July 1974 19 Nov 1974] 8928/74 29984/74 32945/74 and 49982/74 Heading C2U Novel steroids have the formula wherein either X is OH and Y is F, Cl or Br, or X and Y are each Cl, and (i) R 1 is OH, R 2 is OH and R 3 is H, α-CH 3 or #-CH 3 ; or (ii) R 1 is acyloxy, R 2 is OH and R 3 is H, α-acyloxy, α-CH 3 or #-CH 3 ; or (iii) R 1 is OH or acyloxy, R 2 is acyloxy and R 3 is H, α-ChH 3 or #-CH 3 ; or (iv) R 1 is OH or acyloxy and either R 2 is OH and R 3 is α-OH or R 2 , and R 3 together are wherein R 4 is H or hydrocarbyl and R 5 is hydrocarbyl; or (v) R 1 and R 2 together are wherein R 6 is H, hydrocarbyl or alkoxy and R 7 is hydrocarbyl, and R 3 is H, α-CH 3 or #-CH 3 . They may be prepared as illustrated in the following reaction scheme which is largely self-explanatory. (XI)#(XIV) is the reaction of a 17α-acetoxy-16-unsubstituted compound with KOAc in hot DMF. 17α- Esters are prepared from 17α,21-diols via 17,21- o - esters. 17,21 - Acetonides are prepared from the 17α,21-diols and 2,2-dimethoxypropane. The novel steroids have anti-inflammatory activity and they may be made up into pharmaceutical compositions with suitable carriers.
[GB1499822A]
Patent IE-890467-L (IE)
Title: Flexible package
IPC: B65D77/04
Filed: 1989-02-14
Abstract: A package comprising two joined members. One member (21) is a closed member of cardboard (21) or corresponding material and the other member (18) is flexible (18). Said one member has a closed peripheral portion and a completely covering bottom which is continuous with the peripheral portion. The flexible member is fastened along its entire periphery at at least as many points of the outer member that the package has a stable shape.
Patent IE-37481-L (IE)
Title: 3-formylrifamycin azines
IPC: A61K35/74
Filed: 1973-03-30
Abstract: 1392272 Rifamycin derivatives GRUPPO LEPETIT SpA 29 March 1973 [31 May 1972] 15l91/ Heading C2C Derivatives of rifamycin SV having the general formula and 16, 17, 18, 19, 28 and 29 hexahydro and 25-desacetyl derivatives thereof wherein the symbol Rifa represents the rifamycin radical of formula and A represents (1) a direct bond connecting the two nitrogen atoms ; (2) a group wherein y is -CO-, -CNH-, -CS-, -SO 2 -, a divalent, aliphatic, cycloaliphatic, aromatic, araliphatic, or heterocyclic radical; R 2 and R 3 indedendently represent hydrogen, alkyl or taken together represent an aliphatic divalent chain of 1-4 carbon atoms connecting the two terminal nitrogen atoms, or (3) a divalent group wherein X represents a direct bond between the two carbon atoms, a divalent aliphatic, cycloaliphatic, aromatic, or heterocyclic radical, R and R 1 may be independently hydrogen, alkyl, cycloalkyl, aryl, heterocyclic or taken together represent an aliphatic chain of 1 to 8 C atoms connecting the two terminal carbon atoms, may be prepared by reacting 3-formylrifamycin SV or its 25-desacetyl or 16, 17, 18, 19, 28 and 29 hexahydro derivative with a hydrazine compound of the formula H 2 N-A-NH 2 in an inert organic solvent at a temperature ranging from room temperature to the boiling temperature of the solvent. Compounds prepared include 3-formylrifamycin SV azine, 16, 17, 18, 19, 28, 29 - hexahydro - 3 - formylrifamycin SV azine and 1,4-piperazinylidene-bis-(3,3<SP>1</SP>-iminomethyl rifamycin SV). Pharmaceutical compositions having antibacterial and anti-tumour activity comprise the above derivatives of rifamycin SV and a pharmaceutically acceptable carrier.
[GB1392272A]
Patent IE-800743-L (IE)
Title: Peptides having thymopoietin-like activity
IPC: A61K38/00
Filed: 1980-04-11
Abstract: There are disclosed peptides having the following formula: A-X-Z-Y-B wherein A is <CHEM> X is a suitable neutral, aliphatic or aromatic amino acid residue; e.g., one selected from the group consisting of ALA, 2-Me-ALA, GLY, LEU, ILE, LYS, THR, SER, PHE, MET, D-ALA, D-LEU, D-ILE, D-LYS, D-THR, allo-THR, D-SER, D-PHE, D-MET, and SAR; <CHEM> m is 3 or 4; n is 1, 2, or 3; R''' is hydrogen, C1-C7 alkyl, C6-C12 aryl, or C1-C7 alkanoyl; and R and R min are substituents which do not substantially affect the biological activity of the peptides, provided that R-ARG-LYS-ASP-VAL-TYR-R min is excluded. These peptides have the capability of inducing the differentiation of T-lymphocytes but not of complement receptor (CR @) B-lymphocytes and thus are useful in a number of therepeutic areas. Also provided are derivatives of the peptides, therapeutic compositions, and methods for use of the compositions.
[EP0018182A1]
Patent FI-824448-L (FI)
Inventor: NOTA GABRIEL HENRI AUGUSTE
IPC: C09D167/00
Filed: 1982-12-23
Abstract: The invention provides for a coating composition for metal surfaces wherein the binder is made up of (A) 10-80% by weight of a solid, powdered polyamide having a softening point of 110 DEG -230 DEG  C. and an average particle size of 0.5-200  mu  m, (B) 20-90% by weight of a hydroxyl groups-containing polymer having a number average molecular weight of 800-20,000 and a hydroxyl functionality of 1.5-6, and the composition also contains a cross-linking agent for component B in an amount such that the molar ratio of the reactive groups of the cross-linking agent to that of component B is 0.6-1.5, and 40-60% by weight of an organic solvent for component B, the boiling point thereof being 140 DEG -310 DEG  C. The invention also relates to a process for coating a metal surface using said coating composition.
Patent FI-832289-L (FI)
Inventor: BODMER JEROME R
IPC: B41M5/155
Filed: 1983-06-22
Abstract: Pressure sensitive record material carries two coatings one of which is a base coat of a phenolic resin colour developing composition, and the other a topcoat of substantally non-reactive pigment material which is bound on the surface of the colour developing composition. The non-reactive topcoat eliminates the accumulation of contaminants on the fuser roll of copier/duplicators when the record material is printed by photocopier or laser printing operations.
Patent IE-801059-L (IE)
Title: 3-oxoethyl-cephalosporins.
IPC: C07D501/04
Filed: 1980-05-21
Abstract: Novel 3-vinyl-cephalosporins of the formula <IMAGE> (I) in which n is 0 or 1, R1 is hydrogen, a radical of the formula <IMAGE> (II) [in which R4 is hydrogen or a protective radical and R5 is hydrogen, alkyl, vinyl or cyanomethyl or is a protective radical], or a protective radical, and R2 is hydrogen, a protective radical or an enzymatically removable radical, or R1 is hydrogen or an acyl radical which may carry various substituents and R2 is hydrogen or a protective radical, and R3 is a radical of the general formula R'3-SO2-O- or R''3-CO-O-, in which R'3 is alkyl, trifluoromethyl, trichloromethyl or phenyl which is substituted by a halogen atom or by an alkyl or nitro radical, and R''3 is defined like R'3 or represents methyl which is substituted by acyl or alkoxycarbonyl, or represents ethyl or propyl substituted in the 2-position by acyl or alkoxycarbonyl. These compounds are useful as intermediates for the preparation of antibiotic 3-thiovinyl-cephalosporins.
[US4307230A]
Patent IE-831246-L (IE)
Title: Moulding compositions based on polymers reinforced by¹mineral fillers:process for their preparation and their use
IPC: C08K9/04
Filed: 1983-05-26
Abstract: Molding compositions for the fabrication of shaped articles having enhanced mechanical properties are comprised of (i) a polymeric matrix, (ii) an inorganic reinforcing filler material therefor, and, advantageously, (iii) a polymer/filler coupling agent, said reinforcing filler material consisting essentially of intimate admixture of enstatite and silica advantageously prepared by calcination of a precursor clay at a temperature of at least 800 DEG C.
Patent IE-32923-L (IE)
Title: Cultivation of micro-organisms
IPC: C12N1/26
Filed: 1968-11-08
Abstract: 1,241,957. Yeast etc. BRITISH PETROLEUM CO Ltd. Nov. 12, 1968 [Nov. 27 1967], No.53744/67. Heading C6F. A micro-organism is cultivated in the presence of a petroleum fraction consisting wholly or in part of straight chain hydrocarbons, an aqueous nutrient medium and a gas containing free oxygen, the petroleum fraction and aqueous medium being continuously fed to a fermenter containing the micro-organism wherein takes place a first stage of cultivation of the micro-organism, a product stream comprising the micro-organism is continuously passed to a second stage fermenter wherein the micro-organism is treated with a second stage aqueous nutrient medium which consists of a mixture of all or part of the aqueous nutrient medium withdrawn from the first stage fermenter together with additional water, and a product stream comprising micro-organism is continuously removed from the second stage fermenter and treated to recover the microorganism, and in the first stage of cultivation the amount of essential nutrients in the aqueous phase in the first stage fermenter is such that the rate of growth of the micro-organism is not impeded by shortage of nutrients and in the second stage the amount of at least one essential nutrient in the aqueous phase in the second stage fermenter is less than the amount required for unimpeded growth of the micro-organism in the first stage of cultivation and/or at least one essential nutrient which is present in the aqueous phase of the first stage fermenter is absent from the aqueous phase of the second stage fermenter. The second stage aqueous nutrient medium may consist of a mixture of all or part of the aqueous nutrient medium withdrawn from the first stage fermenter together with 1-8 times the volume of additional water, sufficient to reduce any toxin produced in the first stage aqueous nutrient medium to a level insufficient to substantially impede growth in the second stage. The dilution rate used in the operation in the second stage fermenter should not be lower than that used in the first stage fermenter. An example is directed to a two-stage cultivation of Candida tropicalis upon a gas-oil, in the second stage of which the aqueous nutrient medium was deficient in potassium and phosphorus (as phosphate). The cultivated micro-organism may be extracted with n-pentane or n-hexane.
[GB1241957A]
Patent IE-34774-L (IE)
Title: Burner and heat exchanger
IPC: F23M20/00
Filed: 1970-12-01
Abstract: A high intensity burner for burning a carbonaceous fuel in an oxygen containing atmosphere has one or more ports through which the fuel emerges and adjacent which complete combustion of the fuel occurs within a limited combustion region at a temperature above the dissociation temperature of CO2. A heat exchanger, which is maintained at a temperature below the recombination temperature of CO and O2, is located outside the limits of said combustion region but sufficiently close to the burner ports so that, at the normal operating velocity of the burned gases these gases would reach the heat exchanger before the temperature of the gases had dropped below the dissociation temperature and into the recombination temperature range, except for the fact that a screen is located between the limits of the combustion region and the heat exchanger, and is heated by the gases, thereby extracting heat from the gases, to a temperature at which it radiates energy, thus reducing the temperature of such gases into the recombination temperature range before they reach the heat exchanger.
[US3706303A]
Patent IE-811618-L (IE)
Title: Making thin metal ribbons
IPC: B22D11/00
Filed: 1981-07-17
Abstract: A thin strip of metal or alloy is subjected to rapid solidification as it is ejected under pressure in a molten state from a crucible onto a cold, continuous band moving at high speed beneath the crucible's opening, in order to form metal strips in the vitreous state. An atmosphere under reduced pressure surrounding the zone of impact of the molten metal on the band is provided by a partially evacuated housing having opposed narrow inlet and outlet openings through which the band passes. The band is cooled and precisely positioned, and its vibration is minimized, by ejecting fluid from openings in the bottom of the housing, over which the band passes in closely parallel fashion. A pressurized gas at low temperature, ejected through these openings in the direction of the band, creates a fluid cushion between the band and the bottom of the housing. Curved fluid-ejecting units acting analogously to pulleys may be provided to define the path of the continuous band and to form similar fluid cushions between the band and themselves. The metal may advantageously be brought out of the housing by the moving band into an atmosphere of higher pressure before its temperature reaches the temperature of vitrification of the metal.
[US4520859A]
Patent IE-38268-L (IE)
Title: 4-phenyl ethers of 3-amino-5-sulphamoylbenzoic acids
IPC: C07C311/44
Filed: 1973-09-20
Abstract: 4-Phenylethers of 3-amino-5-sulfamoylbenzoic acids, e.g. those of the formula R = an aliphatic or araliphatic radical X = O or S R' = H, alkyl or aminophenyl ALKYL ESTERS OR SALTS THEREOF ARE DIURETIC AGENTS.
[US3992440A]
Patent IE-891713-L (IE)
Title: Substantially closed cell shaped hard phenol foam and method¹for preparing that phenol foam
IPC: C08L61/04
Filed: 1989-06-12
Abstract: A phenol foam and a method for preparing substantially closed cell shaped resins on the basis of the condensation product between, on the one hand an either or not substituted phenol and/or phenol derivative and, on the other hand an aldehyde by using a blowing means for forming a hard phenol foam, whereby a physical blowing means comprising chloropropane is used.
Patent IE-831714-L (IE)
Title: Analgesic and anti-inflammatory compositions
IPC: A61P29/00
Filed: 1983-07-21
Abstract: Novel analgesic and anti-inflammatory compositions of matter for use in eliciting an analgesic or anti-inflammatory response, said compositions comprising ibuprofen and caffeine, are disclosed. When used in combination with ibuprofen, caffeine enhances the analgesic or anti-inflammatory response and also hastens its onset.
[US4420483A]
Patent IE-41453-L (IE)
Title: Separation of citrate or isocitrate by reverse osmosis.
IPC: C07C67/00
Filed: 1975-08-19
Abstract: The process of separating citric acid and/or isocitric acid and their salts from aqueous solutions containing said acids or their salts, and especially from fermentation solutions, consists in contacting said solutions under pressure with a permselective membrane. The material composing said membrane has introduced thereinto acid or basic groups so as to yield membranes of predetermined swelling power. Preferred membranes are those consisting of polyimide or polyamide polycondensation products which are modified by acid or basic groups, of polysulfones modified by acid groups, or of vinyl polymers modified by acid or basic groups. Adjustment of the starting solutions to a pH lower than 3.0 is advantageously effected by means of polyvinylsulfonic acid. (From US4075093 A) [FR2288728A1]
Patent IE-45966-L (IE)
Title: Piperazinylquinazolines
IPC: A61K31/505
Filed: 1977-09-19
Abstract: Certain 2-(4-aroylpiperazin-1-yl)-4-amino-6,7-dimethoxyquinazolines are prepared by a novel process wherein certain 2-(4-substituted-piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline intermediates wherein said substituent is cyano, certain carbon-oxygen double bond containing groups or certain carbon-nitrogen double bond containing groups, are reacted with certain metalloaryl compounds followed by hydrolysis. The products are known hypotensive agents. Certain of the process intermediates are novel compounds.
[US4062844A]