baber/WOPTO huggingface dataset:
Patent JP-3454432-B2 (JP)
IPC: C12Q1/68
Filed: 1997-06-03
Granted: 2003-10-06
Abstract: The invention relates to passive internal references for use in quantitating the formation of amplification products in a nucleic amplification reaction. The internal amplification reference molecules of the invention comprise a first and second fluorophore joined together through a backbone connector. The first and second fluorophores are joined on the backbone in a configuration that permits the energy transfer from the first fluorophore to the second fluorophore. The backbone connector is selected so as not to bind to the target nucleic acid sequence under nucleic acid amplification conditions. Preferably, the backbone connector is a polynucleotide. Another aspect of the invention is to provide passive internal reference molecule containing reagent compositions for use in nucleic acid amplification reactions. The compositions comprise the internal amplification reference molecule of the invention and a nucleic acid amplification reaction buffer. The reagent compositions, optionally, include additional components required for nucleic acid amplification reactions. The invention also provides improved methods of measuring the amount of amplification product in nucleic acid amplification reactions employing fluorescer-quencher probe assays, including methods for the real-time measurement of amplification product formation. The methods comprise the step of adding the internal reference molecule of the invention to the amplification reaction mixture. Fluorescence of the second fluorophore on the internal reference may then be measured and used to calculate changes in fluorescence of the fluorophore on a fluorescer-quencher probe.
Patent JP-2771827-B2 (JP)
IPC: C12N15/09
Filed: 1988-06-13
Granted: 1998-07-02
Abstract: Novel polypeptides having Factor VIII activity are provided as well as compositions and methods for their preparation. The polypeptides comprise derivatives and fragments of Factor VIII and have sequences substantially similar to portions of naturally occuring Pactor VIII. The polypeptides find use in treatment of Hemophilia A.
Patent JP-3091481-B2 (JP)
IPC: E02D29/02
Filed: 1990-04-02
Granted: 2000-09-25
Abstract: The invention provides that wire mesh cage structures are used to provide structural blocks usable in building, shoring, walls and the like. The cage is lined with a geo-textile fibrous material which allows the passage therethrough of water, but not particulate material such as cement, sand aggregate which are used as materials for filling the cage. The cage is of rectangular form with internal partition panels.
Patent JP-3108881-B2 (JP)
IPC: G01L1/00
Filed: 1991-03-04
Granted: 2000-11-13
Abstract: PCT No. PCT/GB91/00328 Sec. 371 Date Oct. 15, 1992 Sec. 102(e) Date Oct. 15, 1992 PCT Filed Mar. 4, 1991 PCT Pub. No. WO91/13832 PCT Pub. Date Sep. 19, 1991A method of, and apparatus for, measuring dynamic torque transmitted by a shaft having an axis of rotation is characterised by the steps of: 1 locating on the shaft (S) a pair of transducers (T, T1, T2), each comprising an SAW resonator, as a complementary pair so that for a first direction of rotation (K) of the shaft (S) about the axis (A) one transducer (T1) is under compression and the other (T2) in tension and for a reverse direction of rotation of the shaft the one transducer (T1) is in tension and the other (T2) in compression, a signal input (C1) and a signal output (C2, C3) for either each transducer or a single signal output for a signal derived from both transducers, the signal input and signal output or outputs being located at discrete locations on or near the outside of the shaft (S) for rotation therewith, 2 causing a driving signal to be applied to the signal input (C1); 3 detecting at each or the signal outlet (C2, C3) at least an output resonant frequency of the transducer (T, T1, T2) when driven by the driving signal; and 4 processing the output resonant frequency signal of each or both transducers to derive information as to the strain generated in the transducer (T1, T2) induced by stress in the shaft (S) due to dynamic torque transmitted by the shaft (S). The invention further provides for various output signals to be provided relating to dynamic torque with or without temperature compensation and/or representation.
Patent JP-2638684-B2 (JP)
IPC: C12Q1/6806
Filed: 1994-08-04
Granted: 1997-08-06
Abstract: A method for the extraction of microbial DNA which renders such DNA amenable for further enzymatic modification in situ, including digestion of the DNA with restriction endonuclease.
Patent JP-2806455-B2 (JP)
IPC: C12Q1/682
Filed: 1989-09-29
Granted: 1998-09-30
Abstract: A probe for the detection of a nucleic acid target sequence containing a molecular switch comprising three essential elements: a probe sequence of 20-60 nucleotides surrounded by switch sequences of 10-40 nucleotides which are complementary to each other, wherein the state of the switch is useful for selectively generating a detectable signal if the probe is hybridized to a target; also, assays and kits utilizing such probes.
Patent JP-H0753464-B2 (JP)
IPC: H04N1/08
Filed: 1990-11-17
Abstract: PCT No. PCT/DE90/00888 Sec. 371 Date Apr. 30, 1992 Sec. 102(e) Date Apr. 30, 1992 PCT Filed Nov. 17, 1990 PCT Pub. No. WO91/07842 PCT Pub. Date May 30, 1991.The invention is directed to a device for clamping sheet-shaped film material onto the recording drum of a reproduction device and is directed to the operation of this device. The recording drum comprises axially proceeding suction-hole rows for the vacuum-fixing of the recording material. Suction channels, each of which connects the suction holes of a suction hole row to one another, proceed in the wall of the recording drum. A vacuum distributor controllable by the rotational movement of the recording drum is arranged in the recording drum, this controllable vacuum distributor selectively bringing the individual suction channels, the corresponding suction hole rows into communication with a stationary vacuum pump. The vacuum distributor is controllable such that that suction hole row on which the starting region of the recording material lies is first charged with vacuum during the clamping event. As a result thereof, a high initial vacuum is achieved, as a result whereof the recording material does not slip. Further suction hole rows are then successively cut-in in accordance with the increasing wrap of the rotating recording drum by the recording material and are charged with vacuum. The cut-in of further suction hole rows is ended in accordance with the respective circumferential length of the recording material at that suction hole row on which the end region of the recording material lies. In particular, large-format recording material can be clamped onto the recording drum without creating folds and warping, and can be reliably fixed thereat with the device.
Patent JP-3553072-B2 (JP)
IPC: B65G45/16
Filed: 1994-12-08
Granted: 2004-08-11
Abstract: PCT No. PCT/EP94/04075 Sec. 371 Date Sep. 17, 1996 Sec. 102(e) Date Sep. 17, 1996 PCT Filed Dec. 8, 1994 PCT Pub. No. WO95/19310 PCT Pub. Date Jul. 20, 1995An arrangement to strip unwanted matter from belt bands in conveyor belt installations, comprises a systems support attached to a supporting structure for the belt band and stripping members each having a scraper blade spring-loaded in the ready-to-operate position against the belt band in a peeling fashion, and can, when the scraper blade encounters obstacles adhering to the belt band, pivot away and subsequently pivot back into the ready-to-operate positions. The blade support is supported by a pivot bearing having a limited pivot angle such that the scraper blade can adjust to changes in inclination of the belt band.
Patent JP-3244507-B2 (JP)
IPC: B65D77/30
Filed: 1996-11-28
Granted: 2002-01-07
Abstract: A sealing assembly (S) for a container (C) with an opening including a sheet (F) welded to the edge of the opening and consisting of at least three layers. The layers comprise a weld layer (1) applied and welded to the edge of the opening along a bead (3), an outer barrier layer (2) and an intermediate adhesive layer (3). The weld between the bead (4) of the weld layer (1) and the edge of the opening has a tear resistance higher than the adhesive force between the weld layer (1) and the adhesive layer. After opening for the first time, the weld bead (4) remains in place along the edge and is separated from the weld layer (1) and the adhesive layer (3) which is thus exposed in an area (7) and enables the container (C) to be resealed by reapplying the layer onto the bead (4). Also claimed are: (i) a container equipped with the claimed sealing assembly; and (ii) a process for the manufacture of the claimed sealing assembly comprising welding the sheet (F) to the edge of the opening along a bead (4).
Patent JP-3723903-B2 (JP)
IPC: B22D39/02
Filed: 1996-03-21
Granted: 2005-12-07
Abstract: PCT No. PCT/AT96/00054 Sec. 371 Date Sep. 19, 1997 Sec. 102(e) Date Sep. 19, 1997 PCT Filed Mar. 21, 1996 PCT Pub. No. WO96/30142 PCT Pub. Date Oct. 3, 1996For charging casting machines with non-ferrous molten metals, melt (S) is supplied from a withdrawal chamber (6) of a melting furnace (1) having a gas atmosphere to the filling hole (18) of a casting machine. To achieve an economic, easily dosable charging of the melt, the metered melt (S) is pumped up inside the withdrawal chamer (6) via a metering pump (12) and is drained towards the filling hole (18) via a discharge pipe (15) extending through the furnace wall, where through inlet nozzles (11) opening into the withdrawal chamber (6) a pulsed supply of gas to the withdrawal chamber (6) is effected to support the melt flow.
Patent JP-3877762-B2 (JP)
IPC: C07D213/78
Filed: 1995-05-04
Granted: 2007-02-07
Abstract: PCT No. PCT/HU95/00014 Sec. 371 Date Nov. 5, 1996 Sec. 102(e) Date Nov. 5, 1996 PCT Filed May 4, 1995 PCT Pub. No. WO95/30649 PCT Pub. Date Nov. 16, 1995Hydroximic acid derivatives possess anti-ischemic effects, and therefore, they are useful for treating ischemic states and diseases, such as myocardial ischemia (which may be induced by occlusion of coronary arteries). These derivatives include compounds of formula (I): wherein: X represents a halogen; Z represents an aromatic group, a pyridinyl group, a picolyl group, or a lutidyl group; and R represents an -A-N(R1)R2 group, wherein: R1 and R2 represent, independently from each other, hydrogen or an alkyl group; or R1 and R2, together with the adjacent nitrogen atom, form a 5- to 7-membered, saturated heterocyclic group optionally containing an additional nitrogen, oxygen, or sulfur atom, the heterocyclic group optionally being substituted by at least one alkyl group; and A represents a straight or branched chain alkylene group, as well as pharmaceutically acceptable acid addition salts thereof. The invention further relates to processes for preparing the above noted compounds, and pharmaceutical compositions containing these compounds or their pharmaceutically acceptable acid addition salts as an active ingredient. Additionally, the invention relates to intermediate compounds of formula II used in preparing the compounds of formula I. Formula II is as follows: In formula II, the variables Z and R have the same definitions provided above.
Patent JP-3631765-B2 (JP)
IPC: C12Q1/68
Filed: 1997-12-30
Granted: 2005-03-23
Abstract: The present invention relates to a novel method for testing the developmental status in pancreatic cells of a mammal. The present invention further relates to applications in the medical field that directly arise from the method of the invention. Additionally, the present invention relates to transgenic mammals comprising at least one inactivated Pax4 allele and optionally at least one inactivated Pax6 allele.
Patent JP-3953111-B2 (JP)
IPC: A61H1/02
Filed: 1997-04-11
Granted: 2007-08-08
Abstract: This invention can be profitably employed in the fields of medicine and sports in the machines used to strengthen the muscles of the knee and in knee tutors.In its simplest version, the articulated joint is formed by two plates (1, 2) which can move freely on one another; alternatively, one plate (1) or the other (2) can be fastened to a fixed structure by means of a fastener.One of the plates features two openings (2.2, 2.3), where the first (2.2) is located at the center of a plate and is shaped like a rectangle. The second opening (2.3) has a specific shape: at first it is a circumference whose radius is equal to "I"; subsequently, it is a spiral which returns towards the center of the plate (2).The other plate features two pins (1.2 and 1.3), located at a distance "I"; the first pin (1.2) is located in the central position and is inserted into opening the (2.2); the second pin (1.3) is in a peripheral position and is located in the second opening (2.3).Alternatively the plate (2) can be replaced by several overlapping plates (3, 4, 5, 6, 7); the semi-plates are arranged in overlapping couples (4, 7 and 5, 6). The semi-plates (4, 7) are fastened to the plate (3) by means of a pin (4.1) placed in an ideal point of rotation (11) and are therefore free to rotate onto the semi-plates (5, 6).
Patent ES-2171356-B2 (ES)
Title: Uso de combinaciones que comprenden azelastina y farmacos alfa-adrenergicos para el tratamiento topico de rinitis/conjuntivitis y sintomas de catarro, tipo catarro y/o gripe.
Inventor: DIEZ CRESPO MARIA DEL CARMEN
IPC: A61K31/445
Filed: 1998-09-11
Granted: 2004-05-01
Abstract: Se reivindica una combinación farmacéutica, aplicable por vía tópica, que contiene una antihistamina no sedante en combinación con un agonista-alfa-adrenérgico y, opcionalmente, vehículos convencionales fisológicamente aceptables, agentes diluyentes y sustancias auxiliares para la profilaxis y el tratamiento de rinitis alérgica y/o vasomotora, conjuntivitis, síntomas de catarro, tipo catarro y/o gripe.
Patent AU-2000223172-B2 (AU)
Title: Delayed video tracking
Inventor: ZAHAVI DOV
IPC: H04N5/225
Filed: 2000-01-31
Granted: 2004-03-11
Abstract: A tracking apparatus including a sensor tracker and a control tracker ( 60 ). The sensor tracker is connected to a sensor which senses a scene having at least one object therein, the sensor tracker provides sensor movement instructions to the sensor, enabling it track a selected object. The control tracker is located remotely from and communicates with the sensor tracker. Additionally, the control tracker takes measurements regarding the selected object and provides tracking instructions to the sensor tracker. The sensor tracker then utilizes the tracking instructions to adjust the sensor movement instructions, when necessary.
Patent AU-2001222700-B2 (AU)
Title: Apparatus for automated ophthalmic lens fabrication
Inventor: SEKHARIPURAM VENKAT
IPC: G02C13/00
Filed: 2000-12-15
Granted: 2005-01-06
Abstract: An apparatus for the automated production of ophthalmic lenses, particularly compound lenses having a plastic coating on a plastic lens is described. A mold, after rotational orientation, is placed in a gimbal assembly to provide for the proper tilt. This gimbal assembly forms part of a fixture attached to an indexing means which moves for complete assembly of a molding fixture and then moves the molding fixture through a chamber to cure the resin. A preform, after rotational orientation, is held, by a preform gripper placed above the mold, and with sufficient clearance between the mold and the preform to allow the correct resin thickness during the curing portion of the process. The fixture is also provided with members to firmly grip the preform gripper so as to maintain its orientation throughout the curing process.
Patent AU-2001259012-B2 (AU)
Title: Method and device for monitoring blood pressure
Inventor: CHUA NGAK HWEE
IPC: A61B5/022
Filed: 2001-05-17
Granted: 2006-07-27
Abstract: A device for continuously monitoring a user's arterial blood pressure has a sensor adapted to continuously detect the blood pressure and to generate signals representative thereof by contact with an external surface of the user's body at a location adjacent an artery. The sensor is securely held in operable contact with the user's body at the location. A microprocessor interprets the signals generated by the sensor to determine actual arterial blood pressure. The sensor includes a projecting portion for detecting and transmitting changes in blood pressure, wherein the projecting portion is adapted to effect at least partial occlusion of the artery at the location.
Patent AU-2001273907-B2 (AU)
Title: A method of producing IgG
Inventor: LINDQUIST LARS-OLOF
IPC: A61K39/395
Filed: 2001-03-29
Granted: 2006-02-02
Abstract: A method for producing IgG from plasma for medical applications, comprising at least: (i') removal of albumin resulting in an IgG fraction, (ii') purifying IgG from an IgG fraction, which is derived from the IgG fraction obtained in step (i'), by adsorbing IgG to a cation exchanger and collecting the adsorbed IgG fraction, and (iii') virus inactivation in an IgG fraction derived from the IgG fraction collected in step (ii'). The method is characterized in; (I) concentrating the IgG fraction obtained in step (i'), (II) adjusting pH to 4±0.1 in the IgG fraction released from the cation exchanger in step (ii'), and preferably maintaining the pH below 6.0 during the remaining steps of the method; and (III) carrying out the virus inactivation (step iii') by using chemicals at a temperature of 30° C.±2° C. for at least 4 hours. Anticomplementary activity is typically below 1 CH50/mg immunoglobulin.
Patent AU-2001284158-B2 (AU)
Title: Spray device
Inventor: STRETTON CAROLINE
IPC: B65D83/38
Filed: 2001-08-15
Granted: 2004-03-25
Abstract: The present invention relates to a spray device (e.g., an inhaler) comprising an aerosol formulation administered to the respiratory or nasal tract in which the level of formulation remaining in the device can be readily inspected. The device comprises a glass vial (1) coated with a coating of polymeric material having at least one clear or translucent portion (4).
Patent AU-2001288730-B2 (AU)
Title: Method for treating allergies using substituted pyrazoles
Inventor: WEI JIANMEI
IPC: A61K31/00
Filed: 2001-09-05
Granted: 2006-01-19
Abstract: A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles of formula (I).
Patent AU-2002213191-B2 (AU)
Title: Devices and methods for body fluid flow control in extracorporeal fluid treatments
Inventor: ASH STEPHEN R
IPC: A61M1/14
Filed: 2001-10-12
Granted: 2006-06-01
Abstract: Disclosed are devices and methods for the control of body fluid flow in the extracorporeal treatment of body fluid. Body fluid flow through on of a body fluid flow circuit (10, 50, 60, 100 or 250) is controlled by alternating applying vacuum pressure and positive pressure to the circuit through a pumping chamber (30, 51, 66, 102, or 200) coordinated with flow control valves (40, 42, 44, 62, 114, 116, 118, and 120) to effect a net downstream flow of body fluid through the circuit.
Patent AU-2002255117-B2 (AU)
Title: Transcobalamin II assay method
Inventor: ORNING LARS
IPC: G01N33/543
Filed: 2002-04-23
Granted: 2008-04-03
Abstract: An assay method for determining transcobalamin saturation wherein a transcobalamin containing liquid sample is contacted with a porous substrate with immobilized thereon a transcobalamin immobilizing ligand and with a reporter-labelled transcobalamin binding partner and wherein signals from reporter labels which become immobilized on said substrate are detected, characterized in that one of said ligand or said binding partner comprises a first ligand or binding partner capable of specific binding to holo transcobalamin and a second ligand or binding partner capable of binding to apo transcobalamin or to holo and apo transcobalamin.
Patent AU-2002319234-B2 (AU)
Title: Method for solubilising asphaltenes in a hydrocarbon mixture
Inventor: CORNELISSE PIETER MARINUS WILL
IPC: C09K8/524
Filed: 2002-06-12
Granted: 2007-09-20
Abstract: Method for solubilising asphaltenes in an asphaltenes-containing hydrocarbon mixture by adding thereto an effective amount of a dendrimeric compound, and a hydrocarbon mixture comprising, in addition to hydrocarbons, asphaltenes and at least one dendrimeric compound. Preferably, the dendrimeric compound is a hyperbranched polyester amide, more preferably a polyester amide built up from succinic anhydride, diisopropanolamine, functionalised with poly (isobutenyl) succinic anhydride.
Patent AU-2002330162-B2 (AU)
Title: Multi-chain eukaryotic display vectors and uses thereof
Inventor: HUFTON SIMON E
IPC: C12N1/19
Filed: 2002-09-30
Granted: 2008-08-07
Abstract: A eukaryotic expression vector capable of displaying a multi-chain polypeptide on the surface of a host cell is provided, such that the biological activity the multi-chain polypeptide is exhibited at the surface of the host cell. Such a vector allows for the display of complex biologically active polypeptides, e.g., biologically active multi-chain polypeptides such as immunoglobulin Fab fragments. The present invention describes and enables the successful display of a multi-chain polypeptide on the surface of a eukaryotic host cell. Preferred vectors are described for expressing the chains of a multi-chain polypeptide in a host cell separately and independently (e.g., under separate vector control elements, and/or on separate expression vectors, thus forming a matched vector set). The use of such matched vector sets provides flexibility and versatility in the generation of eukaryotic display libraries, for example the ability to generate and to display multi-chain polypeptides by combining and recombining vectors that express variegations of the individual chains of a multi-chain polypeptide. Entire repertoires of novel chain combinations can be devised using such vector sets.
Patent AU-2002365036-B2 (AU)
Title: Prevention of flap necrosis in plastic surgery
Inventor: TOONE ERIC J
IPC: A61K33/00
Filed: 2002-12-02
Granted: 2006-09-21
Abstract: NO, NO donor or prodrug that causes formation of nitrosothiol in tissue optionally in combination with lidocaine is topically applied to pedicle of a pedicle flap or other source of blood supply to prevent necrosis in pedicle flap or in any microvascular surgery. Composition containing drug is formulated with nitrosylated polythiolated cyclodextrin to improve drug delivery.
Patent AU-2003241251-B2 (AU)
Title: Biofunctional CpG or oligo-/polynucleotide and toxin or enterotoxin containing composition
Inventor: HARANDI ALI M
IPC: A61K/
Filed: 2003-06-05
Granted: 2008-07-24
Abstract: A bifunctional composition comprising an intracellularly effective immunomodulating nucleic acid component containing at least one immunostimulatory, immunoinhibitory or immunomodulating motif and selected from a mononucleotide, a dinucleotide, an oligonucleotide or a polynucleotide with either a natural phosphodiester backbone or a modified backbone, optionally in combination with a specific antigen, in association with a protein binding to specific receptors on mammalian cell surfaces selected from the group consisting of cholera toxin (CT), the subunit B of CT (CTB), Escherichia coli heat labile enterotoxin (LT), the subunit B of LT (LTB), and proteins or protein derivatives that react with antiserum to CT or LT, bind to GM1 ganglioside, ADP-ribosylates an acceptor protein, or give rise to accumulation of cyclic AMP in target cells, and antibodies or other proteins which after binding to a specific cell surface component can be internalized into the cell, is described. The composition is useful for treatment of tumors, infections, graft rejections, immunosuppressive states, autoimmune diseases and allergies, and further with a specific antigen it is useful for immunoprophylaxis, immunotherapy or induction of tolerance, and for treatment ex vivo of an antigen-presenting cell for subsequent infusion into a mammal for vaccination or immunotherapy purposes.