Patent AU-2020267307-A1 (AU)
Title: Protective effect of dmpc, dmpg, dmpc/dmpg, lysopg and lysopc against drugs that cause channelopathies
Inventor: HELSON LAWRENCE
IPC: A61K47/24
Filed: 2020-11-13
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) 
(19) World Intellectual Property 
(1) OrganizationIIIIIIIIIIIDIIDIDIIIIIIIIIIIIIII 
International Bureau (10) International Publication Number 
(43) International Publication Date W O 2018/075801 Al 
26 April 2018 (26.04.2018) W IPO I PCT 
(51) International Patent Classification: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 
A61K 47/24 (2006.01) A61K31/506 (2006.01) DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, HN, 
(21) International Application Number: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, 
PCT/US2017/057446 KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 
MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 
(22) International Filing Date: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 
19 October 2017 (19.10.2017) SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 
(25) Filing Language: English TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.  
(26) Publication Language: English (84) Designated States (unless otherwise 
indicated, for every 
kind of regional protection available): ARIPO (BW, GH, 
(30) Priority Data: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 
15/297,901 19 October 2016 (19.10.2016) US UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, 
TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 
(71)Applicant:SIGNPATH PHARMA, INC.[US/US];1375 EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 
CaliforniaRoad,Quakertown,PA18951(US). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 
(72) Inventors: HELSON, Lawrence; 1375 California Road, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, 
Quakertown, PA 18951 (US). SHOPP, George, M.; KM, ML, MR, NE, SN, TD, TG).  
860 Willowbrook Road, Boulder, CO 80302 (US).  
BOUCHARD, Annie; 16 Rue De La Pommeraie, Stoke, Published: 
QC JOB 3G0 (CA). MAJEED, Muhammed; 20 Lake Dri- - with international search report (Art. 21(3)) 
ve, East Windsor, NJ 08520 (US).  
(74) Agent: FLORES, Edwin, S. et al.; Chalker Flores, LLP, 
14951 North Dallas Parkway, Suite 400, Dallas, TX 75254 
(US).  
(81) Designated States (unless otherwise indicated, for every 
kind of national protection available): AE, AG, AL, AM, 
AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 
(54) Title: PROTECTIVE EFFECT OF DMPC, DMPG, DMPC/DMPG, EGPG, LYSOPG AND LYSOPC AGAINST DRUGS THAT 
CAUSE CHANNELOPATHIES 
1.20 
T 
S1.00 
0.80 
DMPC 
0.60 -Nilotinib, 0.1 pM 
0.40 DMPC + Nilotinib, 0 1 pM 
0.20 
0.00 
Baseline 
FIGURE 1 
(57) Abstract: The present invention includes compositions and methods for preventing one or more cardiac channelopathies or con
ditions resulting from irregularities or alterations in cardiac patterns caused by an active agent or a drug in a human or animal subject 
comprising: an amount of a phosphatidylglycerol adapted for oral administration effective to reduce or prevent one or more cardiac 
channelopathies or conditions resulting from irregularities or alterations in cardiac patterns caused by the active agent or drug, and one 
or more organoleptic, thixotropic, or both organoleptic and thixotropic agents.