baber/WOPTO huggingface dataset:
Patent DK-0716260-T3 (DK)
Inventor: ANDERSSON JOAKIM
IPC: F16L21/05
Filed: 1991-12-21
Granted: 2000-08-28
Abstract: The joint comprises two sealing surfaces (6, 36), one positioned on each of two end portions (2, 4) of two pipes. The sealing surfaces are adapted axially to be forced together to a position in which one of the sealing surfaces encloses the other sealing surface while forming a cylindrical or somewhat conical sealing space, and further comprising a sealing device positioned in the sealing space thus formed and comprising a sealing ring (18) which is connected with one of the pipe end portions and is compressed in the sealing space. The pipe end portion with which the sealing ring (18) is connected in connection with the sealing ring has a circumferential cavity (34) adapted partially to receive the elastic material of the sealing ring (18) when the joint is provided by axially forcing the sealing surfaces (6, 36) together. The sealing surfaces (6, 36) are adapted after the establishment of the pipe joint to provide sealing space sections having a small and substantially equal space width on either side of the sealing ring (18) in the axial direction of the joint for forming supports for carrying the transverse loads on either side of the sealing ring.
Patent DK-0727165-T3 (DK)
Inventor: SWIER SIWART G
IPC: A47J31/40
Filed: 1996-02-15
Granted: 1999-11-22
Abstract: The invention relates to a machine for dispensing hot beverages suitable for consumption, comprising at least one beverage-dispensing device for dispensing a hot base beverage such as coffee, tea and chocolate, and at least one additive-dispensing device for dispensing an additive to be optionally added to the hot base beverage. The machine further comprises a main discharge channel having an inlet and at least one outlet for dispensing the hot beverage into a container, the inlet being connected to the beverage-dispensing device. The main discharge channel is composed of a number of series-connected modules which each comprise a subchannel having a main inlet and a main outlet, the main outlet of the first module of a first and a second series-connected module being connected to the main inlet of the second module in a liquid-tight manner, and the subchannels of the series-connected modules forming the main discharge channel. At least one module is provided with a side channel which opens into the subchannel of the module and which has an ancillary inlet connected to an additive-dispensing device. <IMAGE>
Patent DK-0874853-T3 (DK)
Inventor: LEE GWAN SUN
IPC: A61P31/04
Filed: 1996-12-26
Granted: 2002-09-23
Abstract: PCT No. PCT/KR96/00250 Sec. 371 Date May 18, 1998 Sec. 102(e) Date May 18, 1998 PCT Filed Dec. 26, 1996 PCT Pub. No. WO97/24358 PCT Pub. Date Jul. 10, 1997The present invention relates to a novel crystalline cefdinir intermediate having formula (II) which can be used very usefully for preparing a cephalosporin antibiotics, cefdinir, in which Ph represents phenyl, p-TsOH represents p-toluenesulfonic acid, and DMAC represents N,N-dimethylacetamide, to a process for preparation thereof and to a process for preparing cefdinir using the compound of formula (II). According to the present invention, cefdinir can be prepared in an excellent color and purity and with a good yield.
Patent DK-0922391-T3 (DK)
Inventor: HAMMES WALTER P PROF
IPC: A23L13/60
Filed: 1997-12-12
Granted: 2007-03-26
Abstract: A composition (A) for the maturation of raw sausage, comprises a probiotic bacterium of the species Lactobacillus, with a survival ratio of 50 % at pH greater than 2.5, and a survival rate of 30 % in a 10 mM choleric acid solution of pH 8.0, measured after 1 hour. Independent claims are also included for: (1) a method for maturing raw sausage, comprising immunizing the raw sausage with (A) and maturing the sausage at 18 degrees C, 70% air humidity for 24 hours; (2) a Lactobacillus casei DSM 11807 and 11808; and (3) the use of the bacillae of (2) in: (a) food stuff and drinks; (b) non-food stuff compositions as a probioticum in animal and human nutrition; (c) animal fodder; and (d) pharmaceutical compositions.
Patent DK-0937599-T3 (DK)
Inventor: SEOANE SANCHEZ JOSE FRANCISCO
IPC: B60P7/04
Filed: 1997-02-28
Granted: 2004-02-02
Abstract: Two single phase motors (1) behind the cable drive canvas roll (4) and chains (13), running in guides (8) down each side of the body, by means of chain drives (6,7). Sliders (15) are fixed to the chains (13) on each side, and carry transverse section (18) to which the end of the canvas is attached by fasteners (21). Vertical draw-plate (19) is hinged to section (18) and serves to level the load in advance of the canvas as this is unrolled. When the canvas is fully extended, plate (19) is lowered and attached to the rear of the vehicle, completely enclosing the contacts.
Patent DK-1012256-T3 (DK)
Inventor: ECK JUERGEN
IPC: A61K47/48
Filed: 1998-01-02
Granted: 2004-07-12
Abstract: The invention relates to nucleic acid molecules which encode fusion proteins which contain as components at least one effector module, a processing module and a targeting module. The nucleic acid molecules according to the invention preferably also encode a modulator module and/or an affinity module. The invention furthermore relates to vectors containing these nucleic acid molecules, hosts transformed with the vectors according to the invention, fusion proteins encoded by nucleic acids according to the invention or produced by the hosts according to the invention as well as to medicaments containing the polypeptides or vectors according to the invention. The invention thus also concerns corresponding processes, uses and kits.
Patent DK-0981362-T3 (DK)
Inventor: DRUCKER DANIEL J
IPC: A61K38/26
Filed: 1998-05-15
Granted: 2004-03-15
Abstract: The invention relates to glucagon-related peptides and their use for the prevention or treatment of disorders involving the upper gastrointestinal tract including the esophagus and stomach. In particular, it has now been demonstrated that GLP-2 and peptidic agonists of GLP-2 can cause proliferation of the tissue of the upper gastrointestinal tract. Thus, the invention provides methods of proliferating the upper gastrointestinal tract in a subject in need thereof. Further, the methods of the invention are useful to treat or prevent inflammatory conditions of the upper gastrointestinal tract, including inflammatory diseases.  GLP-2 stimulates the growth of upper gastrointestinal tissue when administered in conjunction with other peptide hormones. The invention further provides pharmaceutical compositions of GLP-2 with at least one other peptide hormone, methods of enhancing the growth of upper gastrointestinal tissue and of gastrointestinal disorders by increasing serum levels of GLP-2 and at least one other peptide hormone, an kits for performing the methods of the invention.
Patent DK-0980698-T3 (DK)
Inventor: SAELL JANNE
IPC: A63G33/00
Filed: 1999-08-10
Granted: 2008-02-11
Abstract: The invention relates to an arrangement for areas (1) in which means for actuation by persons (2) in a certain way in order to solve a number of problems (E). A control device (3) incorporated in the aforementioned means for achieving automatic control of the solution of the problems comprises at least one of the following automatically acting control devices:     inductive sensor (4),   capacitive sensor,   magnetic contact,   light relay,   movement detector, and   photocell.   The aforementioned control device (3) is connected to an indicator lamp and a lock for a door in the aforementioned area (1) thereby permitting correct or incorrect to be indicated automatically and the door lock to be unlocked once the right solution has been achieved. <IMAGE>
Patent DK-0982302-T3 (DK)
Inventor: JOHNSON ROY A
IPC: A61K31/335
Filed: 1994-06-03
Granted: 2004-08-02
Abstract: of formula (I) and their salts are new: R1 = Me, phenyl (opt. substd. by 1-3 substits. from 1-4C alkyl, 1-3C alkoxy or alkylthio, halo, CF3, 2-6C dialkylamino, OH, or nitro), 2-furyl, 2-thienyl, 1- or 2- naphthyl, or 3,4-methylene-dioxyphenyl; R2 = H, NHCO, 2-11C alkanoylamido, benzamido (opt. substd. by 1-3 substits. as phenyl in R1), NHCOCMe=CHMe, NHCOOCMe3, NHCOOCH2Ph, amino, p-toluene-sulphonamido, NHCO(CH2)3COOH, NHCOC6H4-p-SO3H, OH, NHCO-1-adamantyl, NHCOO-3-tetrahydrofuranyl, NHCOO-4-tetrahydropyranyl, NHCOCH2CMe3, NHCOCMe3, 2-11C alkoxycarbamyl, 2-11C alkylureido, phenylureido (opt. substd. as phenyl in R1), 4-9C cycloalkanoylamido, NHCOCMeEt2, NHCOCMe2CH2Cl, NHCOCMe2Et, phthalimido, 1-phenylcyclopentyl-1-carboxamido, 1-methylcyclohexyl-1-carboxamido, NHCSNHCMe3, or NHCONHCMe3; R3 = H, NHCOPh, or NHCOOCMe3; provided that one of R2, R3 is H, but not both; R4 = H, OH, OAc, OCOCH2CCl3, OCOCH2CH2NH3+HCOO-, NHCOPh, NHCOOCMe3, succinyl, glutaryl, or OCO-Z-COR20; Z = CH2CH2, (CH2)3, CH=CH, 1,2-cyclohexane, or 1,2-phenylene; R20 = OH, OM, NR22R23, OR23, SR23, OCH2CONR24R25, OCO(CH2)nNR32R33, OCOCHR"NH2, prolyl, OCOCH=CH2, succinyl-taurine Na or NBu4 salt, 3-succinyl-amido-propane sulphonic acid Na or NBu4 salt, or OCOCH2CH2COOCH2CH2OH; R32, R33 = H or 1-3C alkyl; R" = H, Me, isobutyl, sec-butyl, isopropyl, benzyl, 4-aminobutyl, CH2CH2COOH, or 4-guanidinopropyl; R5 = H or OH; provided that, when R5 = OH, then R4 = H, and when R5 = H, then R4 is not H; R10 = H or Ac; and R17 = H or benzoyl (opt. substd. by 1-3 substits. from azido, cyano, methoxy, or halo. Also claimed are specified oxazolidine carboxylic esters (V), the corresp. acids (VII) and the 7-acyloxy-baccatin esters of these acids; the deacylation of specified taxol and baccatin III derivs. by reaction with hydrazine; and the prepn. of (V) by condensn. of specified serine derivs. with electron-rich benzaldehydes or acetals.
Patent DK-0967207-T3 (DK)
Inventor: GOLDSTEIN SOLO
IPC: C07D403/04
Filed: 1999-06-24
Granted: 2003-01-20
Abstract: Nitrone substituted imidazole derivatives (I) are new. Nitrone substituted imidazole derivatives (I) and their salts are new. W1 = aryl, 1-6C arylalkyl, heteroaryl or 1-6C heteroarylalkyl; R1 = 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, aryl, cycloalkyl, 1-6C arylalkyl, 1-6C cycloalkylalkyl; R2 = H, 1-5C alkyl, aryl, 1-6C arylalkyl, cycloalkyl, 1-6C cycloalkylalkyl, heterocycloalkyl, 1-6C heterocycloalkylalkyl, heteroaryl, 1-6C heteroarylalkyl, 1-6C acyl, 1-6C alkylsulfonyl, arylsulfonyl, 1-6C arylalkylsulfonyl or 2-6C alkenyl. An Independent claim is also included for the preparation of (I).
Patent DK-1066038-T3 (DK)
Inventor: SCHUELER PETER
IPC: A61P25/14
Filed: 1999-03-24
Granted: 2006-04-24
Abstract: The present invention provides for the use of cabergoline and other agents for the treatment of restless legs syndrome (RLS).
Patent DK-1086225-T3 (DK)
Inventor: ROWE PETER
IPC: G01N33/15
Filed: 1999-05-18
Granted: 2007-05-21
Abstract: The present invention relates to a novel human protein called phosphatonin, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
Patent ES-2204449-T3 (ES)
Inventor: GAMBINI GIOVANNI
IPC: B31F1/07
Filed: 2000-10-26
Granted: 2004-05-01
Abstract: A multi-purpose embossing machine (11) for producing embossed paper comprises a bottom body (12), which supports a first embossing assembly (34) that works associated to a second embossing assembly (36). The machine 11 has a top body (18) which supports the second embossing assembly (36) in a position corresponding to the first embossing assembly (34), said top body (18) being connected to the bottom body (12) via a supporting and actuating element (52, 54) designed to support at least part of the weight of the top body (18) during operation of the embossing machine (11) and to enable the bottom body (12) and the top body (18) to be moved apart from one another in a situation of danger. Also provided is a resting element (26) set between the top body (18) and the bottom body (12). <IMAGE>
Patent ES-2194674-T3 (ES)
Title: Mezcla de cargas para vidrio de sosa-cal-silice por flotacion.
Inventor: HIGBY PAIGE L
IPC: C03C6/00
Filed: 1995-07-17
Granted: 2003-12-01
Abstract: Una mezcla de cargas para vidrio para producir un vidrio de sosa-cal-sílice que contiene óxidos de hierro que comprende una fuente de silicio, una fuente de sodio, una fuente de calcio y wuestita.
Patent ES-2199744-T3 (ES)
Inventor: LASSERRE PIERRE-ANDRE
IPC: B65D83/16
Filed: 2000-03-24
Granted: 2004-03-01
Abstract: Nozzle (20) comprises chamber (32) and membrane (36) able to create vacuum inside conduit (29) so that, after each actuation valve (5), residual product present in conduit is vacuumed through vacuuming aperture (31) to recovery zone (35) within chamber. Recovery zone is partially defined under inlet (34) level of chamber. An Independent claim is also included for the dispenser.
Patent ES-2233302-T3 (ES)
Inventor: METH-COHN OTTO
IPC: C07D211/32
Filed: 2000-05-02
Granted: 2005-06-16
Abstract: Pyridine and piperidine derivatives (I) are new. Pyridine and piperidine derivatives of formula (I), their enantiomers and diastereoisomers, acid and base salts, are new. A = pyridine, pyridinium, or piperidine; R2 = H; R3 = OH, or together with R2 forms oxo; R4 = phenyl, naphthyl or heteroaryl (all optionally substituted); R1 = H or R1 - R4, together with the two C atoms to which they are attached, form a 6C ring, or R1 and R2 form a bond, in which case R3 is a 5- or 6-membered heterocycle linked through N and which may contain a further hetero atom (O, N, S); R5 = a 5-6 membered heterocycle linked through N optionally containing a hetero atom (O, N, S), or a group of formula (II); R'1-R'4 = have the same meanings as R1-R4, or they may be H, in which case R4 is not unsubstituted phenyl, naphthyl, or heteroaryl; R6 = H, 1-6C alkyl or absent; with the provisos that (a) when A = piperidine, R2-R3 form oxo, R5 = H, and R6 =H or is absent, then R4 is other than phenyl substituted by one group OH, alkoxy, CF3, or halogen other than Br, or by more than one group OH and alkoxy, (b) when R2 = H, R3 = OH, R5 = H, R6 = H or is not there, then R4 is not phenyl substituted by one Cl, OH, alkoxy or alkyl group, or by more than one OH or alkoxy group and (c) (I) is not 1-(1,3-benzodioxol-5-yl)-2-(2-pyridinyl) ethanol or 2-(2-pyridinyl) cyclohexanone.
Patent ES-2231138-T3 (ES)
Inventor: BONNINGUE PHILIPPE
IPC: B65D83/76
Filed: 2000-09-05
Granted: 2005-05-16
Abstract: Pump (10) has base (13) and telescopic assembly (30) defining pumping chamber (60). Telescopic assembly comprises outer sleeve (31) in which inner obtruding sleeve (32) slides. When outer sleeve is displaced to decrease volume of pumping chamber, assembly takes up dispensing configuration and obtruder closes filling orifice (21). When the outer sleeve is displaced to increase the pumping chamber volume the assembly takes up its filling configuration and the obtruder ceases to seal the filling orifice.
Patent ES-2301478-T3 (ES)
Inventor: DEANE ROBERT J
IPC: E04C2/54
Filed: 2000-01-14
Granted: 2008-07-01
Abstract: Two parallel glass panes are separated by a core spacer made of either EPDM rubber or another solid rubber material with a nonheating, centrally positioned, nonstretchable fiberglass cord being embedded therein and extending longitudinally therethrough so that the core spacer is not stretchable. The EPDM rubber formulation is chemically compatible with hot melt butyl which is used as an adhesive between the solid rubber and the glass panes. The fiberglass cord is nonstretchable so that the core spacer does not deform or break apart when the core spacer is either initially manufactured or later placed between the pair of two glass panes. The core spacer and the cord extend around a periphery and go around corners between the panes in an airtight manner to form an insulated assembly. Also, the cord has a diameter no greater than about 10% of a width of the core spacer. A method for manufacturing the insulated assembly is likewise disclosed.
Patent ES-2325674-T3 (ES)
Title: Benzoimidazoles con sustitucion de cicloalquilos y su utilizacion como inhibidores de la parp.
Inventor: LUBISCH WILFRIED
IPC: A61P31/04
Filed: 2000-04-11
Granted: 2009-09-14
Abstract: Compuestos de las fórmulas I o II ** ver fórmula** en las que A significa un carbociclo saturado o insaturado una vez con 3 a 8 átomos de carbono, el cual puede tener adicionalmente un anillo bencénico fusionado; los anillos pueden estar sustituidos con uno o dos residuos R 3 diferentes o iguales así como con el residuo R 4 , y R 1 es hidrógeno, y R 2 puede ser hidrógeno, C1-C6-alquilo ramificado y no ramificado, C1-C4-alquil-fenilo, y R 3 puede ser C 1-C 6-alquilo, OH, O-C 1-C 4-alquilo, O-C 1-C 4-alquil-fenilo, NR 11 R 12 , fenilo, C 1-C 4-alquil-fenilo, CF3, COOH, COO-C1-C4-alquilo, CONH-C1-C4-alquilo, CONH2, donde los anillos fenilo además pueden estar sustituidos con máximo dos residuos R 31 iguales o diferentes, donde R 11 y R 12 independientemente uno de otro significan hidrógeno o C 1-C 4-alquilo y R 31 puede ser OH, C1-C6-alquilo, O-C1-C4-alquilo, cloro, bromo, yodo, flúor, CF3, nitro, NR 11 R 12 , y R 4 significa -(O) p-(CH 2) q-B, donde B significa NR 41 R 42 y ** ver fórmula** donde p puede significar 0 y 1 y q puede ser 0, 1, 2 ó 3, donde si q = 0, p = 0 también, y R 41 puede ser hidrógeno, C1-C6-alquilo, (CH2)r-E y R42 puede ser hidrógeno, C1-C6-alquilo, -CO-R 8 , SO2-R 8 , -(C=N)-R 8 y -(C=N)-NHR 8 y r puede ser 0, 1, 2, 3, 4 y E puede ser fenilo que puede tener máximo dos residuos R 72 y cuando r 1 0, entonces es 1, también NR 11 R 12 , NH- C1-C4-alquil-fenilo, pirrolidina, piperidina, dihidropiperidina, morfolina, homopiperidina, piperazina que puede estar sustituida además con C1-C6-alquilo y C1-C4-alquil-fenilo, y homopiperazina que puede estar sustituida además con C 1-C 6-alquilo y C 1-C 4-alquil-fenilo, y R 7 puede ser hidrógeno, C1-C6-alquilo, fenilo, donde el anillo puede estar sustituido además con hasta dos residuos R 71 iguales o diferentes, y R 71 puede ser OH, C 1-C 6-alquilo, O-C 1-C 4-alquilo, cloro, bromo, yodo, flúor, CF 3, nitro, NR 11 R 12 , NHO-C 1-C 4alquilo y R 72 puede ser OH, C1-C6-alquilo, O-C1-C4-alquilo, cloro, bromo, yodo, flúor, CF3, nitro, NR11R12, NHO-C1-C4alquilo y R 8 puede ser C1-C6-alquilo, fenilo, C1-C4-alquil-fenil-O-C1-C4-alquil-fenilo, donde los anillos pueden estar sustituidos además con hasta dos residuos R 81 iguales o diferentes, y R 81 puede ser OH, C 1-C 6-alquilo, O-C 1-C 4-alquilo, cloro, bromo, yodo, flúor, CF 3, nitro, NR 11 R 12 , y R 9 es hidrógeno, C1-C6-alquilo, C1-C4-alquil-fenilo, fenilo, y los anillos pueden estar sustituidos además con hasta dos residuos R 91 , y R 91 puede ser OH, C 1-C 6-alquilo, O-C 1-C 4-alquilo, cloro, bromo, yodo, flúor, CF 3, nitro, NR 11 R 12 , así como sus formas tautoméricas, posibles enantiómeros y formas diaestereoméricas, posibles cis-trans-isómeros en los anillos en A y sus fosfatos, carbamatos de aminoácidos y ésteres.
Patent ES-2206231-T3 (ES)
Inventor: CHIESA GIUSEPPE
IPC: H04L29/08
Filed: 2000-05-05
Granted: 2004-05-16
Abstract: System for integrating voice and data in telecommunication networks comprising: a) one or more application servers (1) mutually connected through a data network (2) and provided with at least a microprocessor (3), a RAM memory (4), a network interface (5), which are controlled by an operating system (6) provided with a message manager; b) at least one server (7) acting as a file and/or database server; c) one or more communication devices (10) which are installed on at least one application server (1) and are connected to the telephone network (11), wherein d) said communication devices (10) are controlled by communication plug-ins (12) supported by a software platform (13) installed on the application servers (1); (e) said software platform (13) employs one or more plug-ins (12, 16, 17) according to the data received by one or more message handling components (14) suitable to receive in the network (2) messages (15) in a standard format containing data for the execution of these plug-ins (12, 16, 17), said messages being structured in a manner independent from the relevant content; (f) said plug-ins (12, 16, 17) comprise one or more executing plug-ins (17) which execute instructions transmitted by the message handling components (14) according to the data contained in said messages (15); (g) said file and/or database server (7) comprises further data for executing said instructions for the executing plug-ins (17). The present invention also relates to a process which can be carried out by means of such a system.
Patent ES-2298147-T3 (ES)
Inventor: FREDERIKSEN OLE
IPC: B65G69/28
Filed: 2000-07-03
Granted: 2008-05-16
Abstract: For facilitating the passage of wheelchair users over door thresholds it is known to lay out ramp elements across the threshold, this however being an expensive solution even implying that the door cannot be closed. The invention provides for a ramp set suited to be laid out at both sides of the threshold so as to leave the top side thereof uncovered, whereby the door can still be opened and closed. The ramp construction is modular based on the use of light, joinable plastic tile elements of ordinary shape and wedge shape, respectively, and this makes it possible to build up non-costly, tailored ramp constructions in more general, with an associated possibility of reusing the tile elements.
Patent ES-2246243-T3 (ES)
Inventor: ALBONETTI STEFANIA
IPC: C07D307/60
Filed: 2000-05-30
Granted: 2006-02-16
Abstract: Active vanadium/phosphorus mixed oxide catalyst for the conversion of non-aromatic hydrocarbons, e.g., n-butane, into maleic anhydride. The catalyst is prepared from the catalyst precursor, that is, prepared by the reaction of a source of vanadium in an organic medium in the presence of a phosphorus source. The organic medium is (a) isobutyl alcohol or a mixture of isobutyl alcohol and benzyl alcohol and (b) a polyol. The catalyst precurso is transformed into the active catalyst by an activation process that includes a heat treatment that includes applying a temperature of up to 600° C.
Patent ES-2340911-T3 (ES)
Title: Hilado con alma resistente al fuego y tejido que comprende el mismo.
Inventor: LAND FRANK J
IPC: D02G3/44
Filed: 2000-08-22
Granted: 2010-06-11
Abstract: Hilado con alma resistente al fuego (100), que comprende: un alma (102) de filamento continuo resistente a altas temperaturas que comprende fibra de vidrio; una primera vaina (104) de fibras cortadas mezcladas que rodea el alma, comprendiendo las fibras fibras de melamina, caracterizado porque, en la primera vaina (104) de fibras cortadas mezcladas que rodea el alma las fibras comprenden fibras modacrílicas y fibras de melamina; y porque dicho hilado comprende una segunda vaina (106) de fibras cortadas que rodea el primer hilado con alma.
Patent ES-2302701-T3 (ES)
Title: N3'-p5' tiofosforamidatos oligonucleotidicos: su sintesis y uso.
Inventor: GRYAZNOV SERGEI
IPC: C07H21/00
Filed: 2000-09-08
Granted: 2008-08-01
Abstract: Un oligonucleótido que comprende una secuencia no homopolímera de subunidades de nucleósido, unidas por al menos un enlace entre las subunidades que es un N3-->P5'' tiofosforamidato definido por la fórmula: 3''-[-NH-P(=O)(-SR)-O-]-5'' en donde R se selecciona del grupo que consiste en hidrógeno, alquilo, arilo, y sus sales, y en donde el oligonucleótido puede inhibir o reducir la actividad de telomerasa en al menos 10% comparada con un control en el cual la enzima no está tratada con el oligonucleótido.