Patent SG-11201805532X-A (SG)
Title: Multivalent and multispecific 41bb-binding fusion proteins
Inventor: ECKELMAN BRENDAN P
IPC: A61K39/395
Filed: 2017-01-11
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, I1 Organization M1111101110101011111 HO 1111101110111011100110111001101111111011 International Bureau ... ...., (10) International Publication Number (43) International Publication Date ..... .....r .,i WO 2017/123650 A2 20 July 2017 (20.07.2017) WIPO I PCT (51) International Patent Classification: Torrey Pines Road, Suite 280, La Jolla, California 92037 C07K 16/28 (2006.01) (US). RASON, Lucas; 11099 N. Torrey Pines Road, Suite (21) International Application Number: 280, La Jolla, California 92037 (US). DEVERAUX, PCT/US2017/013040 Quinn; 11099 N. Torrey Pines Road, Suite 280, La Jolla, California 92037 (US). (22) International Filing Date: (74) Agents: KARNAKIS, Jennifer A. et al.; Cooley LLP, 11 January 2017 (11.01.2017) 1299 Pennsylvania Avenue, NW, Suite 700, Washington, (25) Filing Language: English District of Columbia 20004 (US). (26) Publication Language: English (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (30) Priority Data: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, 62/277,028 11 January 2016 (11.01.2016) US BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (71) Applicant: INHIBRX LP [US/US]; 11099 N. Torrey DO, DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, Pines Road, Suite 280, La Jolla, California 92037 (US). HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (72) Inventors: ECKELMAN, Brendan P.; 11099 N. Torrey MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, Pines Road, Suite 280, La Jolla, California 92037 (US). NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, TIMMER, John C.; 11099 N. Torrey Pines Road, Suite RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 280, La Jolla, California 92037 (US). HATA, Chelsie; TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, 11099 N. Torrey Pines Road, Suite 280, La Jolla, Califor- ZA, ZM, ZW. nia 92037 (US). JONES, Kyle S.; 11099 N. Torrey Pines Road, Suite 280, La Jolla, California 92037 (US). HUS- (84) Designated States (unless otherwise indicated, for every — _ SAIN, Abrahim; 11099 N. Torrey Pines Road, Suite 280, kind of regional protection available): ARIPO (BW, GH, La Jolla, California 92037 (US). RAZAI, Amir S.; 11099 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, _ = N. Torrey Pines Road, Suite 280, La Jolla, California TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 92037 (US). BECKLUND, Bryan; 11099 N. Torrey Pines TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, = Road, Suite 280, La Jolla, California 92037 (US). PAN- DK, EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, = LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, DIT, Raj ay; 11099 N. Torrey Pines Road, Suite 280, La SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Jolla, California 92037 (US). KAPLAN, Mike; 11099 N. = — GW, KM, ML, MR, NE, SN, TD, TG). [Continued on next page] = = (54) Title: MULTIVALENT AND MULTISPECIFIC 41BB-BINDING FUSION PROTEINS = = FIG. 13 = INBRX-105-1-A (PDL1 x 41 BB) INBRX-105-1-B (PDL1 x 41BB) = PDL1 sdAb PDL1 sdAb PDL1 sdAb PDL1 sdAb = N sdAb 41BB sdAb Fc { kin 1::+ © Fc - if41BB 41BB sdAb* sdAb M ei ,-1 IN 1-1 (57) : This invention relates generally to molecules that specifically engage 41BB, a member of the TNF receptor superfam - 0 ily (TNFRSF). More specifically, this invention relates to multivalent and multispecific molecules that bind at least 41BB. ei 0 WO 2017/123650 A2 MIDIOHOMMIMMEMEIMMIIIMIONONMEHOIS Declarations under Rule 4.17: Published: — as to applicant's entitlement a patent (Rule 4.1700) to apply for and be granted — without international search report and to upon receipt of that report (Rule 48.2(g)) be republished