Patent SG-11201807401R-A (SG)
Title: Therapeutic membrane vesicles
Inventor: LOTVALL JAN
IPC: G01N33/50
Filed: 2017-03-15
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization MD 1111101110101011111 HO 11111 011101111011 MIMI 010110111110111011# International Bureau ... .... ..Yjd ..... ...,/ (10) International Publication Number (43) International Publication Date WO 2017/161010 Al 21 September 2017 (21.09.2017) WIP0 I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every CO7K 1/30 (2006.01) GO1N 1/34 (2006.01) kind of national protection available): AE, AG, AL, AM, C12N 15/90 (2006.01) GO1N 1/38 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, C12Q 1/68 (2006.01) G01N 33/50 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, PCT/US2017/022544 KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (22) International Filing Date: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 15 March 2017 (15.03.2017) NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (25) Filing Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (26) Publication Language: English ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 62/308,805 15 March 2016 (15.03.2016) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: CODIAK BIOSCIENCES, INC. [US/US]; TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, 500 Technology Square, 9th Floor, Cambridge, Massachu- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, setts 02139 (US). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors: LOTVALL, Jan; Codiak BioSciences, Inc., LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, 500 Technology Square, 9th Floor, Cambridge, Massachu- _ setts 02139 (US). JANG, Su, Chul; Codiak BioSciences, GW, KM, ML, MR, NE, SN, TD, TG). — Inc., 500 Technology Square, 9th Floor, Cambridge, Mas- Declarations under Rule 4.17: — sachusetts 02139 (US). — — of inventorship (Rule 4.17(iv)) Agents: SUN, Danqiong Fenwick LLP, 801 = (74) et al.; & West Published: California Street, Mountain View, CA 94041 (US). — with international search report (Art. 21(3)) = = = = (54) Title: THERAPEUTIC MEMBRANE VESICLES = Figure 1 = = Antibody or aptamer bead conjugation bead = = = = _ = EV 1-1 3 / 3 © 61. Elution Il © Il Sub-populations of EV Il IN 1-1 (57) : The present invention relates to a method for producing membrane vesicles from extracellular vesicles or organelles 0 and therapeutic membrane vesicles produced by such method. The invention further relates to therapeutic membrane vesicles, a \" method of treating a metabolic disorder by using such vesicles and such vesicles for use in therapy, such as in treatment of a meta - C bolic disorder. The invention further relates to a method of producing a membrane vesicle from an organelle. In addition, the present invention relates to a method of separating a sub-population of extracellular vesicles from an extracellular vesicle bulk.