Patent SG-11201809658U-A (SG)
Title: Tablet-in-tablet pharmaceutical composition comprising cyclophosphamide and capecitabine
Inventor: PATEL PRIYANK
IPC: A61K31/7072
Filed: 2017-05-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111111111111111111111101111111111111H11111011111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2017/191553 Al 09 November 2017 (09.11.2017) W I P0 I P C T (51) International Patent Classification: (84) Designated States (unless otherwise indicated, for every A61K 31/7072 (2006.01) kind of regional protection available): ARIPO (BW, GH, (21) International Application Number: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, PCT/1B2017/052534 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (22) International Filing Date: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 02 May 2017 (02.05.2017) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (25) Filing Language: English KM, ML, MR, NE, SN, TD, TG). (26) Publication Language: English Declarations under Rule 4.17: (30) Priority Data: — as to applicant's entitlement to apply for and be granted a 201621015342 03 May 2016 (03.05.2016) IN patent (Rule 4.1 7(ii)) (71) Applicant: INTAS PHARMACEUTICALS LTD. — as to the applicant's entitlement to claim the priority of the [IN/IN]; Intas Pharmaceuticals Ltd., 2nd Floor, Chinubhai earlier application (Rule 4.1 7(iii)) Centre, Ashram Road, Ahmedabad— 380009, Gujarat (IN). Published: (72) Inventors: PATEL, Priyank; Intas Pharmaceuticals Ltd — with international search report (Art. 21(3)) - Astron Division, 2nd & 10th Floor, Premier House — 1, Opp. Gurudwara, S. G. Highway, Bodakdev, Ahmedabad — 380054, Gujarat (IN). PATEL, Mayur; Intas Pharma- ceuticals Ltd - Astron Division, 2nd & 10th Floor, Premier — = House — 1, Opp. Gurudwara, S. G. Highway, Bodakdev, Ahmedabad— 380054, Gujarat (IN). PATEL, Mahendra; = _ Intas Pharmaceuticals Ltd - Astron Division, 2nd & 10th Floor, Premier House — 1, Opp. Gurudwara, S. G. Highway, Bodakdev, Ahmedabad — 380054, Gujarat (IN). SINGH, = Balvir; Intas Pharmaceuticals Ltd - Astron Division, 2nd & 10th Floor, Premier House — 1, Opp. Gurudwara, S. G. = _ Highway, Bodakdev, Ahmedabad — 380054, Gujarat (IN). SEHGAL, Ashish; Intas pharmaceuticals Limited - Astron — Division, 2nd & 10th Floor, Premier House-1, Bodakdev, _ Opp. Gurudwara, Sarkhej — Gandhinagar Highway, Ahmed- _ abad = 380054. Gujarat (IN). (74) Agent: PATHAK, Alpesh; Intas Pharmaceuticals Ltd - Astron Division, 2nd & 10th Floor, Premier House 1, — = Opp. Gurudwara, S. G. Highway, Bodakdev, Ahmedabad — = = 380054, Gujarat (IN). = (81) Designated States (unless otherwise indicated, for every kind of national available): AE, AG, AL, AM, = protection — AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = — CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, _ = DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, _ MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 1-1 PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, M TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. in in Il 0\ Il N (54) Title: TABLET-IN-TABLET PHARMACEUTICAL COMPOSITION COMPRISING CYCLOPHOSPHAMIDE AND 1-1 CAPECITABINE 0 ei (57) : The present invention relates to a stable tablet-in-tablet pharmaceutical composition comprising fixed dose combinations C of cyclophosphamide and capecitabine and one or more pharmaceutically acceptable excipient, process for the preparation thereof, and their use in treating cancer diseases.