baber/WOPTO huggingface dataset:
Patent CR-20210054-A (CR)
Title: Immunotherapy with b*07 restricted peptides and combination of peptides against cancers and related methods
Inventor: SCHOOR OLIVER
IPC: C07K14/47
Filed: 2019-07-30
Abstract: <p>The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor- associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.</p>
Patent CR-20210060-A (CR)
Title: Activators of the unfolded protein response
Inventor: HERGENROTHER PAUL J
IPC: C07D307/83
Filed: 2019-07-01
Abstract: <p>A set of small molecules ERα biomodulators that kill therapy-resistant ERα positive breast, ovarian, and endometrial cancer cells. These small molecules have increased therapeutic potential because of an increased ability to kill therapy-resistant breast cancer cells compared to BHPI and other conventional therapies (endocrine therapies, tamoxifen and fulvestrant/ICI). The new compounds do not only inhibit proliferation of the cancer cells but actually kills them, which prevents reactivation of tumors years later.</p>
Patent CR-20210144-A (CR)
Title: Macrocyclic broad spectrum antibiotics
Inventor: HANAN EMILY J
IPC: C07D245/04
Filed: 2018-02-22
Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
Patent EC-SP993294-A (EC)
Title: 4- oxo-1,4- dihidro -3-quinoleincarboxamidas como agentes antivirales
Inventor: STROHBACH JOSEPH WALTER
IPC: A61K31/47
Filed: 1999-12-23
Abstract: La presente invención provee a compuestos de fórmula I (gráfico), En donde, R1 es C1-7 alquilo, opcionalemente sustituido con hidroxilo o NR4R5, R2 es C1-7 alquilo sustituido con hidroxilo o NR4R5; R3 es H, F o C1-7 alcoxilo; R4 y R5 conjuntamnete con N son radicales heterocíclico de 5 o 6 miembros que tienen 1-3 heteroátomos seleccionados del grupo formado de nitrógeno, oxígeno y azufre en el cual el azufre puede estar sustituido por uno (1) o dos (2) átomos de oxígeno; y sus sales farmacéuticamente aceptables. Los compuestos de fórmula I de la presente invención son útiles como agentes antivirales.
Patent EG-22999-A (EG)
Title: Dredge cutterhead
Inventor: OLLINGER CHARLES G IV
IPC: E02F3/92
Filed: 2002-02-02
Granted: 2003-12-31
Abstract: A dredge cutterhead has a plurality of helical arms inter-connecting a hub and a ring. Each of the arms has a front leading edge for attachment of cutting teeth. In one aspect, each of the arms has a trough portion, and the arm is shaped such that dredged material is directed toward the ring along the center of the trough portion. In another aspect, the ring of the cutterhead defines an annular channel for receiving loosened material.
Patent FI-20002217-A (FI)
Inventor: WATANABE WIWIK
IPC: A61K9/72
Filed: 2000-10-06
Abstract: A method for preparing particles suitable for pulmonary drug delivery by inhalation, and inhalation compositions comprising such particles are provided. The method comprises providing a liquid feed stock comprising one or several active agents, atomising the liquid feed stock, suspending the droplets in a carrier gas, and passing the carrier gas and droplets through a heated tube flow reactor under predetermined residence time and temperature history, and collecting the particles produced. Fine uniform crystalline spherical uncharged particles with narrow aerodynamic particle size distribution between about 1 to 5 mum and rough surfaces, are obtained. The particles show improved dispersibility and stability.
Patent FI-20022035-A (FI)
Inventor: PAAKKINEN ANTTI
IPC: G01M99/00
Filed: 2002-11-15
Abstract: The object of the invention is a method for defining elastic deformations and integral angle between of the most important parts of a gyratory compactor, in which method the angle of gyration of a gyratory compactor is measured during the use of the gyratory compactor. The object of the invention is also a device, which includes measuring elements (13, 20; 27, 28) for measuring the angle of gyration of a gyratory compactor. Characteristic to the method in accordance with the invention is the fact that a loading device (1) is adjusted in the place of mass specimen, the loading of which on the gyratory compactor is earlier known and that the gyratory compactor will be in use while the loading device (1) is inside the gyratory compactor. Characteristic to the device in accordance with the invention is the fact that the device includes at least one loading device which can be placed inside the specimen cylinder mold of the gyratory compactor.
Patent FR-1143121-A (FR)
Inventor: WRENE NILS TORSTEN
IPC: F24F6/12
Filed: 1955-11-07
Granted: 1957-09-26
Abstract: 779,847. Contacting liquids with gases. WRENE, N. T. June 24, 1955 [Nov. 10, 1954], No. 18388/55. Class 55 (2). Gases to be purified by contact with a liquid are introduced through a U-shaped conduit 1 arranged in a vessel 2 containing water and a rotating cylinder 3 which sprays the gases through a gap 6 in the lower wall of the conduit, the washed gases leave through a device 9 for removing excess moisture. The lower wall of the conduit has a second gap 19 which enables any heavier particles in the gases to be discharged directly into the water in the vessel 2. In a modification a number of units of the type described may be arranged in series with a common feed of liquid to the rotors. Parts of the apparatus liable to corrosion may be coated with polyvinyl chloride.
Patent GB-1051583-A (GB)
IPC: H03H9/24
Abstract: 1,051,583. Vibratory elements. BRASTED BROTHERS Ltd. July 18, 1963 [April 18, 1962], No. 15134/62. Heading G5J. To reduce the coloration imparted to the tonal quality of the fundamental frequency produced by a vibrating element when secured directly to a rigid structure, a single resilient member having a fundamental frequency below human audibility is used to secure the vibrating element to the rigid structure at a position of minimum vibratory displacement. The element comprises a steel rod of circular crosssection bent into a U-shape 14, 15, and the resilient member 5 is formed with an aperture 9 adjacent one end through which the element is threaded until the member engages over the web 16 of the element. A piezo-electric transducer, from which an electrical output is obtained, is secured to one limb of the element by a tube 18 of distortable material, e.g. rubber or artificial rubber. The resilient member 5 is secured to the rigid structure 4 of an instrument, e.g. an electronic musical instrument, by means of screws 3. In a further embodiment, Fig. 4, not shown, an insert is secured by means of screws on to the head 6 of the resilient member and the aperture 9 so formed is shaped to conform to the shape of the vibrating element. The vibrating element may be of U-shape stamped from sheet material (Fig. 5, not shown) or a straight rod or tube supported at one end by a resilient member (Fig. 6, not shown). The resilient member may be of rubber, artificial rubber or plastics material such as nylon.
Patent GB-1231361-A (GB)
IPC: C09D101/18
Filed: 1969-02-04
Abstract: 1,231,361. Coated materials. NATIONAL AERONAUTICS & SPACE ADMINISTRATION. 4 Feb., 1969 [9 Feb., 1968], No. 5818/ 69. Heading B2E. [Also in Divisions C3, C4 and C5] Steel, zinc chromate-coated steel, aluminium, wood, paper, or asbestos may be coated with a fire-retardant, intumescent paint comprising a volatile, thermoplastic or thermally unstable vehicle containing a sulphate or sulphonate of an aromatic nitro-amino compound in which at least one each of the nitro and amino groups is attached to the aromatic nucleus, and reactive positions on the nucleus are not substituted by thermally stable groups (see Division C4-5). Para-nitroaniline sulphate is the preferred intumescent agent. The vehicle may be a cellulose nitrate solution, or the paint may comprise a partially polymerised solid PNA sulphate above in a solvent. In Example I steel plate is coated with a dispersion of PNA sulphate in cellulose dinitrate, methyl ethyl ketone and ethanol, and overcoated with cellulose nitrate.
Patent GB-1232154-A (GB)
IPC: H01J31/16
Filed: 1969-08-04
Abstract: 1,232,154. Cathode-ray tubes. STROMBERG DATAGRAPHIX Inc. 4 Aug., 1969 [19 Aug., 1968], No. 38863/69. Heading H1D. A shaped-beam cathode-ray tube comprises a beam-shaping plate 13, a beam-trimming plate 16 and a mesh 18 adjacent the trimming plate for dividing the beam and producing uniform intensity over the beam-trimming aperture 17. The beam passes through an Einzel lens consisting of annular electrodes 24, 27 maintained at the same positive potential and separated by a tube 26 maintained at earth potential. The potentials applied to the lens and to focusing electrode 23 determine the cross-section of the beam at the mesh 18 and trimming plate 17, both of which are within the tube 26. By means of deflection electrodes 29, 31 the beam is directed through one of a number of shaped apertures 14 in the shaping plate 13 and thence directed by a further lens 32, 52, 62, deflection electrodes 33, 34 and deflection yoke 36 on to a screen 12. The lens 32, 52, 62 is adjusted to image one of the shaping apertures 14 on the screen. The effect of the mesh 18 is to produce uniform intensity of the beam at the operative shaping aperture 14 with a sharp cut-off at the edge of the aperture. The electrodes 23, 24, 27 are adjusted so that the mesh is not imaged in the plane of the shaping apertures 14.
Patent GB-1238856-A (GB)
IPC: H01H37/52
Filed: 1968-05-10
Abstract: 1,238,856. Metallic springs. TURNRIGHT CONTROLS Ltd. 7 May, 1969 [10 May, 1968], No. 22360/68. Heading F2S. [Also in Division H1] An electric snap-action switch includes a flexible contact-actuating element 1 and a compression element 4 arranged to form a stressed over-centre snap-acting assembly, element 1 having at one end one or more mounting tabs 8 connected with element 1 by a neck or necks 17, the tab 8 or tabs being firmly clamped to mount element 1 at one end and the arrangement of the tab or tabs and the neck or necks being such that movement of element 1 to cause snap action of the assembly involves twisting the or each neck 17 about its longitudinal axis. As shown, compression element 4 is integral with spring blade 1 but could be separate. Blade 1 carries a contact 23 but may actuate the contact indirectly, e.g. in a push-pull rod or other linkage. A lever 12 is riveted, welded or otherwise secured to blade 1, lever 12 having forked arms 14, Figs. 2A, 4A (not shown) which fit over side arms 9 on both sides of the cut-out 7 forming the tab 8. Lever 12 carries a ceramic insulating dolly 18 through which force is transmitted to snap over spring blade 1. Blade 1 is riveted through tab 8 to a support 19. The switch as described above is mounted in an energy regulator for an electric cooker hotplate (see Division H1).
Patent GB-1250561-A (GB)
IPC: E03D11/11
Filed: 1969-02-07
Abstract: 1,250,561. Chemical closets. WESTING- HOUSE BRAKE & SIGNAL CO. Ltd. 9 Feb., 1970 [7 Feb., 1969; 4 March, 1969], Nos. 6701/69 and 11425/69. Heading E1C. In chemical toilet apparatus comprising a pan 1 which is flushed by chemical liquid, preferably re-circulated from a tank 3 into which the pan discharges, the tank is equipped with upper and lower sensors 8, 9 which, via a control unit 10, control a macerator unit 4, for discharging the tank 3 when full, and a dosing valve 12 for supplying chemical in the form of tablets to the tank 3 from a dispenser 19, the arrangement being such that when the tank 3 becomes filled to the high level it is first emptied via macerator pump 7 and discharge pipes 5, 6 until the low level is attained, upon which a fresh chemical tablet is dispensed by the closing valve 12. In the preferred re-circulatory system shown a footoperated device 16, e.g. a switch 22, is actuated by the user to energise a flush pump motor 15 of a pump unit 14 to re-circulate chemically treated liquid from the tank 3 via a filter 13 to flush the pan 1. An alarm is adapted to be actuated should tank 3 overfill.
Patent GB-1250595-A (GB)
IPC: F23C99/00
Filed: 1970-02-12
Abstract: 1,250,595. Infra-red burner. I. PELLIZZETTI. 12 Feb., 1970 [18 Feb., 1969], No. 6875/70. Heading F4T. In an infra-red radiant burner for vaporized liquid fuel, combustion takes place on a perforated heat resistant panel 1 forming one wall of a mixing chamber 3, which is supplied with air and fuel vapour through a venturi tube 4, the fuel vapour emerging from nozzle 11 after being produced from liquid fuel in a vaporizer body 5 which is mounted adjacent to the panel 1. The vaporizer consists of a vaporizing chamber 6 which is supplied with liquid fuel via a conduit 77 and from which fuel vapour passes to the nozzle 11 which is formed from a tube 12 on which a sleeve 15 is a sliding fit. A needle 13 is formed at the end of tube 12 which has holes 14 to allow fuel vapour to pass to the inside of sleeve 15 and through the hole 17 which is adapted to receive needle 13. Bellows 18, preferably of metal, sealingly connect and bias apart flanges 12a and 16 formed on tube 12 and sleeve 15 respectively. A lever 19 is adapted to transmit manual movement of a rod 24 to the sleeve 15, such movement being usable to provide fine adjustment of the rate of supply of fuel vapour to the burner, to close down the supply of fuel completely or to clean the hole 17 with the needle 13 and, by causing a pressure rise in the chamber 6, remove impurities by forcing the liquid fuel to flow back through the supply conduit. An electric resistor 29 is provided to enable vaporization of liquid fuel to occur when starting from cold and the portion 29a provides ignition. A thermostat (not shown) cuts off the electric supply to resistor 29 after ignition is established. A thermostat 30 is coupled to an electromechanical valve 31.  In a modification (Fig. 4, not shown), a bimetal strip is used to provide automatic control of the nozzle 11 in place of the manual control afforded by rod 24 and lever 19. In another embodiment (Figs. 5 and 6, not shown), the mixing chamber is cylindrical and is formed within a cylindrical perforated heat resistant panel.
Patent GB-1266539-A (GB)
IPC: C08G18/40
Filed: 1969-06-03
Abstract: 1,266,539. Polyurethane foam. ELASTOMER A.G. 3 June, 1969 [7 June, 1968], No. 28119/69. Headings C3C and C3R. Cellular polyurethane having a density of at least 0À4 g./cm.<SP>3</SP> is prepared by reacting: (I) a substantially linear polyether or polyester polyol (M.W. 1000-3000), (II) an organic chain extender (M.W. <500) containing alcoholic OH groups, (III) a second chain extender (M.W. 500-600) having alcoholic OH groups and ester or ether groups, (IV) water and (V) an organic polyisocyanate. Both I and III may be hydroxycaprolactone esters or poly(tetramethylene ether)glycol. II may be a glycol optionally mixed with a triol. From 3À25-4À2 moles of III may be used per mole of II. V may be employed so as to provide 0À7-1À3 NCO groups per OH group and may be reacted substantially simultaneously with the other reactive ingredients. V may be a reaction product of carbodiimide with 4,4<SP>1</SP>-diphenylmethane diisocyanate.
Patent GB-1295470-A (GB)
IPC: F16B12/20
Filed: 1969-11-14
Abstract: 1295470 Furniture joints J BLUM 14 Nov 1969 [14 Nov 19681 55997/69 Heading A4H [Also in Division E2] A pin 1 is locked in a bore 6 in a structural element 4 by a rotatable locking device 9 housed in a bore 7 in member 4 inclined to bore 6, device 9 including a helicoidal surface 16 that co-operates with an inclined surface 20 on pin 1. Pin 1 and element 4 engage in bores in wooden panels and are retained therein by ribs 35. Helicoidal surface 16 is provided on a collar 14 that extends over an angle of 270 degrees around the device 9, and a radial stop rib (17) is provided at the end of surface 16 for abutting a projection 19 on pin 1. A collar 11 on device 9 provided with a screwdriver slot (18) is forced past a narrower part 8 of bore 7, element 4 and/or device 9 being resilient. When device 9 is rotated a conical end 13 thereof bears on the bottom of the panel bore. The lower part 12 of device 9 may be wide enough to bear on pin 1.
Patent GB-1297072-A (GB)
IPC: B23B31/20
Filed: 1970-03-23
Abstract: 1297072 Chucks; cutter arbors BOFORS AB 23 March 1970 [24 March 1969] 13982/70 Headings B3B and B3K A chuck, e.g. for the shanks of milling tools, comprises a body 1 for mounting in a machine spindle, a conical recess 3 in said body, a clamping nut 6, and a conical split collect 4 engageable in said recess 3, and is characterized in that quick release interengaging projection 16, 17, on the nut and collet respectively allow the collet 4 to be rotated to disengage the projections 17 from behind the projections 16 and be withdrawn from the body whilst the nut 6 is still attached to thereto. When the nut 6 is screwed to tighten a grip on a tool shank, sloping faces in the projections 16, 17, engage to contract the collet 4. The nut 6 includes a threaded part 7 and a ring 10 connected to the part 7 by means of balls 13 so that tongues 11 can engage in grooves 12 to hold the ring 10 stationary relative to the support 1. A ring of balls 20 engage in a groove 19 to ensure that the nut 6 cannot be removed from the support 1. A pin 24 ensures correct alignment  of the projections 16, 17. The collet 4 can be removed and a suitably shaped shank of a tool can be gripped directly.
Patent GB-1297607-A (GB)
IPC: F15B11/02
Filed: 1971-04-19
Abstract: 1297607 Fluid-pressure servomotor systems UNITED AIRCRAFT CORP 19 April 1971 [20 March 1970] 22600/71 Heading G3P An isochronous governor for controlling fuel to a jet engine comprises a bell-crank 28, 30 receiving a speed error which is the difference between the predetermined speed and the scheduled speed, an integrating valve 36 whose output is the integral of the error, a proportional valve 50 whose output is proportional to the error, and an actuator 75 controlled by the outputs to regulate the fuel flow. The spool 34 of the integrating valve 36 is moved in response to movement of the bell-crank 28, 30 to either admit pressure regulated fluid P R  to the output line 70 via a channel 98 or allow fluid in line 70 to communicate with a drain P D  depending on the polarity of the error. The spool 34 is constantly rotated at a set speed, and fluid enters the line 70 by way of vanes 100. The piston 52 of the proportional valve is biased downwardly by pressure regulated fluid P R  and upwardly by pressure regulated fluid P R  acting over a smaller area. A flapper 46 controls fluid discharge from the chamber 60 fixed to the piston so that an error signal conveyed to the flapper via a lever 40 causes a corresponding movement in the piston 52 and a consequential displacement of fluid from beneath the piston into or out of the line 70. Adjustable stops limit the stroke of piston 52 so that full travel to the corrective position is prevented thus minimizing overshooting or undershooting.
Patent GB-1303968-A (GB)
IPC: B23K20/12
Filed: 1969-03-06
Abstract: 1303968 Welding by pressure JOHN THOMPSON (PIPEWORK & ORDNANCE DIVISION) Ltd 6 March 1970 [6 March 1969] 23045/72 Divided out of 1293183 Heading B3R In a friction welding machine having means 19 for urging workpieces 12, 16 together the resultant bending load which arises in the frame structure is compensated for by a device located below the axis 13 of the workpieces so as to prevent misalignment of the workpieces. In a first embodiment a compensating ram 33 applies to a part 32 of the frame a load which is proportional or equal to the load applied by the ram 19 so that the bed 17 is kept substantially free of bending load. In a second embodiment (Fig. 2) the bed 17 is pivotally connected to two uprights 40, 41 the workholders 15, 11 being mounted on the bed 17 and upright 40, and a strut of adjustable length disposed between the uprights 40, 41 ensures that at the forging load applied by the ram 19 the workpieces are properly aligned.
Patent GB-1306084-A (GB)
IPC: A01B63/111
Filed: 1969-07-21
Abstract: 1306084 Tractor lift-links MARSHALLFOWLER Ltd 8 July 1970 [21 July 1969 30 Oct 1969 (2)] 25815/69 53184/69 and 53185/69 Heading A1P The two lower lift-links 6, 7 of a tractor three-point-hitch are operated by rams 1a, 1b. A pump 9 supplies fluid from a reservoir 8 through flow-divider 12 and lines 13, 14 to control valves 10, 11 which are operated by spools 19, 15. Spool 15 may be manually set to one of four positions "raise" (line 14 is connected to line 17 and line 18 to line 16), "lower" (14 to 16 and 18 to 17), "hold" (16, 17 closed and 14 to 18) or "float" (16 to 17 and 14 to 18). A linkage 23 which may be hydraulic or mechanical (e.g. cable and pulley or Bowden cable) transmits the movements of ram 1b to the spool 19 of the valve 10 to keep ram 1a in step. The movements of ram 1b may be amplified by the linkage 23 or a constant height difference maintained between the two. A torsion-bar overload relief mechanism (Fig. 4, not shown) for the valve 11 and a spring damper (62), Fig. 5 (not shown) for the valve 10 are described. To permit the implement attached to the links 6, 7 to slew about a vertical axis the hitch may be attached to a subframe which is pivoted to the tractor about an axis which passes through the centre of pull of the tractor. Alternatively, the members 42 and 43 may be pivotally connected to vertical support rods (54), Fig. 5 (not shown) which are carried by fixed brackets so that they are able to rotate about vertical axes.
Patent GB-1311804-A (GB)
Title: Panelling constructions
IPC: E04B2/78
Filed: 1970-01-29
Abstract: 1311804 Panelled cladding D LANGHAN 19 April 1971 [29 Jan 1970 3 July 1970] 4307/70 and 32499/70 Headings E1B and E1W Wall, ceiling or roof cladding comprises an asbestos, chipboard, plywood or paper honeycomb core 6, with longitudinal rearwardly extending edge flanges of metal or plastics either attached to rebates in the panel edge or formed integrally with a panel facing 4 of plastics coated steel or aluminium which flanges releasably and resiliently engage with plastics or metal channel members 2 fixed to supporting studs or joists 1, when a separate flange is used a facing 4 of plastics may be clamped between the flange and one side of the rebate. A P.V.C. or neoprene vapour and expansion seal may be inserted between adjacent panel flanges within the member 2. A removable P.V.C. coated, aluminium skirting, not shown, may be clipped under the base of the panels to conceal service conduits. Coving comprising a sprung aluminium strip may conceal the upper panel edge. Cladding may be secured to box section plastics coated, aluminium or steel columns 1 located in sockets embedded in the foundation.
Patent GB-1312252-A (GB)
Title: Manganese compounds
IPC: C01G45/02
Filed: 1969-06-23
Abstract: 1312252 Recovery of manganese values KODAK Ltd 18 June 1970 [23 June 1969] 31603/69 Heading C1A [Also in Division C2] Manganous hydroxide is precipitated when a liquor containing at least one manganese salt is added to an aqueous solution of ammonia, or of a substituted ammonium hydroxide having a pKa value greater than 9, to reduce the pH of the latter solution from at least 10 to within the range 9À0-9À5. The separated hydroxide may be converted to trimanganese tetroxide either by heating in the presence of air or oxygen, or by stirring in deionized water at elevated temperature whilst passing air or oxygen therethrough. It is preferred to carry out the precipitation of manganese hydroxide at a constant temperature in the range 25-35‹ C. and in the absence of air.