baber/WOPTO huggingface dataset:
Patent TW-202207638-A (TW)
Title: Precision digital to analog conversion in the presence of variable and uncertain fractional bit contributions
Inventor: VAN ZYL GIDEON
IPC: H03M1/12
Filed: 2019-05-13
Abstract: This disclosure describes systems, methods, and apparatus for a digital-to-analog (DAC) converter, that can be part of a variable capacitor and/or a match network. The DAC can include a digital input, an analog output, N contributors (e.g., switched capacitors), and an interconnect topology connecting the N contributors, generating a sum of their contributions (e.g., sum of capacitances), and providing the sum to the analog output. The N contributors can form a sub-binary sequence when their contributions to the sum are ordered by average contribution. Also, the gap size between a maximum contribution of one contributor, and a minimum contribution of a subsequent contributor, is less than D, where D is less than or equal to two time a maximum contribution of the first or smallest of the N contributors.
Patent TW-202319874-A (TW)
Inventor: YEH PING-SHENG
IPC: G06F1/20
Filed: 2021-11-04
Abstract: An air-cooling and liquid-cooling shared tray module includes a main body and a quick connecting module. The quick connecting module includes a bracket. The bracket is movably disposed on the main body to switch the quick connecting module between an air cooling mode and a liquid cooling mode. When the quick connecting module is switched to the air cooling mode, the quick connecting module is stored in the main body. When the quick connecting module is switched to the liquid cooling mode, the quick connecting module extends out of the main body.
Patent TW-202319879-A (TW)
Inventor: SUN PEI-HUA
IPC: G06F1/26
Filed: 2021-11-10
Abstract: A power supply regulating circuit, a charging device and a power supply mode adjustment method thereof are provided. The power supply mode adjustment method is adapted to the power supply regulating circuit, and the method includes controlling the power supply regulating circuit into power transmission state, and detecting a charging current to obtain a detection value among the detection time; determining the detection value to be within a trickle value range, a constant-voltage value range or a constant-current value range; corresponding to the above value range, adjusting the power supply regulating circuit into power transmission state or power stagnation state continually for a first duration, a second duration or a third duration. The value of the trickle value range is smaller than the value of the constant-voltage value range, and the value of the constant-voltage value range is smaller than the value of the constant-current value range.
Patent TW-202233325-A (TW)
Title: Method for calculating rolling condition for cold rolling mill, device for calculating rolling condition for cold rolling mill, cold rolling method, cold rolling mill, and method for manufacturing steel sheet
Inventor: FUJITA NORIKI
IPC: B21B37/28
Filed: 2021-11-10
Abstract: The method for calculating a rolling condition for a cold rolling mill according to the present invention includes: an estimation step for inputting second multidimensional data, generated on the basis of unsteady rolling performance data regarding unsteady rolling of a material subject to rolling, into a prediction model trained using, as an explanatory variable, first multidimensional data generated on the basis of unsteady rolling performance data, and as response variables, rolling constraint condition data regarding steady rolling and steady rolling performance data, from among past rolling performances when a rolling material was rolled by means of a cold rolling mill, and thereby estimating a rolling constraint condition of the material subject to rolling with respect to a target steady rolling condition; and a changing step for changing the target steady rolling condition so that the estimated rolling constraint condition satisfies a prescribed condition.
Patent TW-202236790-A (TW)
Title: Power electronics module
Inventor: SUBRAMONIAN SURESH
IPC: H02M1/44
Filed: 2021-11-10
Abstract: A power electronic module comprising a housing that receives at least one power converter is provided. The housing contains a polymer composition that includes an electromagnetic interference filler distributed within a polymer matrix. The polymer matrix contains a thermoplastic polymer having a deflection temperature under load of about 40 DEG C or more as determined in accordance with ISO 75-2:2013 at a load of 1.8 MPa. Further, the composition exhibits an electromagnetic interference shielding effectiveness of about 25 decibels or more as determined in accordance with ASTM D4935-18 at a frequency of 30 MHz and thickness of 3 millimeters.
Patent TW-202229976-A (TW)
Title: Microarray-type diffusion plate
Inventor: IKEDA KEISUKE
IPC: G02B26/10
Filed: 2021-11-17
Abstract: According to the present invention, lenses are disposed in a lattice on an array surface (32) of a micro lens array (31). A lens (30) has a cylindrical convex surface through cross-sections which are parallel to the lattice direction of the lens (30) and perpendicular to the array surface (32). On each of the lines of longitude on each cross-section parallel to the lattice direction of the lens (30), a sag amount is corrected so that the inclination of skirt increases. A lens according to another aspect has a cylindrical concave surface through cross-sections which are parallel to the lattice direction of the lens and perpendicular to an array surface. On each of the line of longitude on each cross-section parallel to the lattice direction of the lens, a sag amount is corrected so that the inclination of a rim increases.
Patent TW-202229322-A (TW)
Inventor: LI PING
IPC: A61P25/00
Filed: 2021-11-19
Abstract: 本發明涉及長效神經生長因數(Nerve Growth Factor，NGF)多肽，從N端到C端包含NGF部分和Fc部分，及其製備方法和用途。
Patent TW-202231191-A (TW)
Title: Method for improving cooked rice food products
Inventor: NAKAJIMA KEI
IPC: A23L7/10
Filed: 2021-12-13
Abstract: Provided is an art for improving cooked rice food products. Cooked rice food products are improved by the use of the following component (A): (A) [alpha]-amylase derived from Bacillus licheniformis.
Patent TW-202326778-A (TW)
Inventor: JU TAI
IPC: H01H19/14
Filed: 2021-12-23
Abstract: 一種具旋鈕功能之電子裝置、壓電旋鈕及其操作方法。具旋鈕功能之筆記型電腦包括一殼體及一壓電旋鈕。部分之壓電旋鈕露出於殼體之外。壓電旋鈕包括一環型底座、一第一環型電極、一第二環型電極、一壓電材料、一上蓋、一推抵元件及一轉軸。環形底座之厚度沿一環型方向逐漸減少。第一環型電極與第二環型電極以同心圓之方式設置於環型底座上。壓電材料至少設置於第一環型電極及第二環型電極之間。上蓋覆蓋環型底座。推抵元件連接上蓋，並推抵壓電材料。轉軸連接上蓋，以使上蓋及推抵元件以轉軸為中心相對環型底座轉動。
Patent TW-202233740-A (TW)
Title: Polyvinyl alcohol film and polarizing film obtained therefrom
Inventor: KAZETO OSAMU
IPC: B29C41/26
Filed: 2021-12-28
Abstract: The purpose of the present invention is to provide a PVA film that makes it possible to obtain a polarizing film without diminishing the high polarization performance when the PVA film is stretched at a high stretching speed. The purpose of the present invention is also to provide a polarizing film using such a PVA film as the starting material. Provided is a polyvinyl alcohol film that contains a polyvinyl alcohol having a degree of saponification of at least 98 mol% and a degree of polymerization of 1200 to 8000, wherein formula (1) is satisfied by the results of measuring the polyvinyl alcohol with a gel permeation chromatograph at a measurement temperature of 40 DEG C and using hexafluoroisopropanol having 20 mM sodium trifluoroacetic acid added thereto as a mobile phase solvent. Formula (1): 0.017 ≤ Huv2/Hri2 ≤ 0.030 (provided that: Huv2 is the detection strength at an absorption wavelength of 210 nm for a polymethyl methacrylate-based molecular weight in which the base 10 logarithm is 4.3, obtained using an ultraviolet/visible light detector (UV detector) of a gel permeation chromatograph; and Hri2 is the detection strength for a polymethyl methacrylate-based molecular weight in which the base 10 logarithm is 4.3, obtained using a refractive index detector (RI detector) of a gel permeation chromatograph).
Patent TW-202244205-A (TW)
Title: Polymeric dispersant and production method therefor, aqueous pigment dispersion, and water-based ink-jet ink
Inventor: SHIMANAKA HIROYUKI
IPC: C09D11/40
Filed: 2022-01-13
Abstract: Provided is a polymeric dispersant to be incorporated for producing an aqueous pigment dispersion capable of giving a water-based ink-jet ink in which the pigment is stably and highly finely dispersed and with which images excellent in terms of adhesion and durability can be recorded on plastic media or cloth. The polymeric dispersant, which is for dispersing pigments, is to be incorporated in producing an aqueous pigment dispersion for use in water-based ink-jet inks for plastic-medium printing or textile printing and is a polymer satisfying the requirement (1), etc. Requirement (1): To contain a structural unit (i) derived from styrene, a structural unit (ii) derived from methyl methacrylate, etc., a structural unit (iii) derived from 2-ethylhexyl methacrylate, etc., a structural unit (iv) derived from 2-hydroxyethyl methacrylate, etc., and a structural unit (v) derived from methacrylic acid, at least some of the carboxy groups having been neutralized with an alkali.
Patent TW-202300208-A (TW)
Title: Purification method and purified product
Inventor: FURIHATA KIYOMI
IPC: B01D15/42
Filed: 2022-02-24
Abstract: This Description provides a method for purifying a compound using column chromatography and provides a method for optimizing the symmetry coefficient and theoretical number of plates by sedimenting a slurry and reducing the sedimentation volume of the slurry. Also provided are compounds that have been purified by these methods.
Patent TW-202306901-A (TW)
Inventor: ESKEN DANIEL
IPC: C01F7/30
Filed: 2022-03-23
Abstract: 本發明係關於經塗布有熱解製成之二氧化鈦及/或熱解製成之氧化鋁的基於紅鉛之核殼粒子、用於製備這樣的核殼粒子之方法及其在鉛酸電池的用途。
Patent TW-202304315-A (TW)
Title: Feed for livestock
Inventor: KOJO HIROSHI
IPC: A23K20/184
Filed: 2022-03-30
Abstract: A feed for livestock is provided that shows excellent body weight gain. A feed additive composition and a feed for livestock comprising abscisic acid and/or a salt thereof and microbial-derived materials; a method of breeding livestock or improving the weight gain of livestock, comprising letting livestock to take said feed for livestock; and a use of the feed for livestock for improving the weight gain of livestock.
Patent TW-202307606-A (TW)
Inventor: PATERSON IAN CRAIG
IPC: G05D7/03
Filed: 2022-04-08
Abstract: 本發明揭示一種以高效率對一高壓工作流體進行操作之系統、方法及設備。裝置具有一高壓工作流體儲集器。一流體連接件在一受控工作壓力下將該高壓工作流體供應至用以容納一定體積之該高壓工作流體的一劑量室。經偏壓以關閉且能夠經觸發打開之一劑量閥存在於該劑量室與一工作室之間。一定充注量之該高壓工作流體可在該工作室之一第一端處經由該劑量閥自該劑量室釋放，以在該工作室中經歷一第一次膨脹並在其中向或朝向該工作室之遠離該第一端之一第二端做功。該劑量閥在該工作室中之該充注量的一壓力鋒所行進距離小於或等於該第一端與該第二端間距的一半之前再次關閉。此允許該充注量之一第二次膨脹以繼續做功。當該做功結束時，工作室壓力小於或等於該工作壓力的一半。
Patent TW-202243047-A (TW)
Title: Sheet, thinned wafer handling sheet, thin wafer handling method, and thin device handling method
Inventor: KATO HIDETO
IPC: H01L23/28
Filed: 2022-04-11
Abstract: The present invention relates to a sheet characterized by having on a surface thereof a plurality of structural bodies that each have a cylindrical or semicylindrical shape with a height of 50-500 [mu]m and a diameter of 10 [mu]m to 1 mm, or have a prismatic shape with a length of 100 [mu]m to 1 mm and a thickness of 10 [mu]m to 1 mm. The sheet is also characterized by: having on the surface thereof a structure in which the plurality of structural bodies are arranged at an equal interval, or a structure in which the plurality of structural bodies are arranged such that the maximum value of intervals therebetween is less than three-fold of the minimum value of the intervals; and being formed from a thermosetting resin. Accordingly, it is possible to provide: a sheet that enables easy handling of a thinned wafer or a mold-sealed relocated element and that has excellent chemical resistant properties; a thinned wafer handling sheet including the sheet; and a thin wafer handling method and a thin device handling method which use the thinned wafer handling sheet.
Patent TW-202245358-A (TW)
Title: Connector and Assembly Method
Inventor: ISHIMARU MASAO
IPC: H01R13/6581
Filed: 2022-04-13
Abstract: A second connector 3 is provided with: a base unit 500 having a connector base 510, insulating first and second housings 520A and 520B that protrude in the same direction from the connector base 510 along a fitting direction D22, a first signal contact 530A held by the first housing 520A and connected to a first signal conductor 24 of a first cable 20A, and a second signal contact 530B held by the second housing 520B and connected to a second signal conductor 24 of a second cable 20B; and, electro conductive first and second shells 600A and 600B fixed to the connector base 510 so as to respectively surround the first and second housings 520A and 520B around an axis that extends along the fitting direction D22.
Patent TW-202311169-A (TW)
Title: Inorganic oxide powder, method for producing same, and resin composition
Inventor: OKABE TAKUTO
IPC: C08K7/18
Filed: 2022-05-20
Abstract: Provided are: an inorganic oxide powder which makes it possible to simultaneously attain a high dielectric constant and a low dielectric loss tangent when filling with a resin material; a method for producing the same; and a resin composition which contains said inorganic oxide powder. Provided is an inorganic oxide powder containing spherical titanium oxide powder which has a rutile phase, wherein the rutile phase constitutes a proportion of at least 90 mass% of the inorganic oxide powder. This resin composition contains said inorganic oxide powder, and one or more resins selected from a thermoplastic resin and a heat-curable resin.
Patent TW-202303068-A (TW)
Title: Modular fluid heat exchange systems
Inventor: MOSTAFAVI YAZDI SEYED KAMALEDDIN
IPC: F28F3/02
Filed: 2022-05-20
Abstract: A modular heat exchange assembly includes a cold plate defining a finned surface and a corresponding plurality of microchannels. Selected ones of the plurality of microchannel extend from a first end to an opposed second end. A fluid receiver unit defines an inlet port and a first fluid connector fluidically coupled with the inlet port. A fluid transfer unit defines an outlet port and a second fluid connector matingly engageable with and disengageable from the first fluid connector to fluidly couple the fluid receiver unit and the fluid transfer unit together. The fluid transfer unit defines a distribution manifold configured to distribute coolant among the selected microchannels at a position between the first ends and the second ends of the selected microchannels. The fluid transfer unit further defines a collection manifold configured to receive coolant from the selected microchannels. The collection manifold and the outlet port are fluidically coupled together.
Patent TW-202307507-A (TW)
Inventor: TAYLOR BYRON
IPC: G02B7/02
Filed: 2022-05-24
Abstract: 本發明描述一種用於設計光學構件以提供被動消熱差及像差校正之系統。該系統可包括一處理器及儲存指令之一記憶體。當執行所述指令時，該處理器可使得該系統基於所接收設計規格而選擇待包括於該光學構件中之一或多個光學元件，基於該所選擇一或多個光學元件而選擇一或多個光學元件組態，及實施一最佳化函數以最佳化該所選擇一或多個光學元件組態。當執行所述指令時，該處理器可接著判定該一或多個光學元件組態是否滿足一或多個初始規格，使得能夠對該一或多個光學元件組態進行一或多個調整，及判定一光學元件組態是否滿足一或多個額外規格。
Patent TW-202317057-A (TW)
Inventor: LIU SHIH-TA
IPC: A61H9/00
Filed: 2021-10-22
Abstract: A negative pressure massage apparatus includes a vacuum pump, two solenoid valves and a control board. The vacuum pump is used to generate a negative pressure outside the negative pressure massage apparatus. Two solenoid valves are used to control an air flow input into the negative pressure massage apparatus. The control board is used to start or stop at least one of the vacuum pump, and the two solenoid valves.
Patent TW-202308111-A (TW)
Inventor: KIM HYUN-CHEOL
IPC: G11C7/12
Filed: 2022-06-16
Abstract: 本發明提供一種半導體記憶體裝置，包含：多個半導體圖案，在第一水平方向上延伸且在第二水平方向及豎直方向上彼此分離，每一半導體圖案包含第一源極/汲極區域、通道區域以及配置於第一水平方向上的第二源極/汲極區域；多個閘極絕緣層，覆蓋通道區域的上部表面或側表面；多個字元線，位於通道區域的上部表面或側表面上；以及多個電阻式切換單元，分別連接至半導體圖案的第一側壁，在第一水平方向上延伸且在第二水平方向及豎直方向上彼此分離，每一電阻式切換單元包含第一電極、第二電極以及位於第一電極與第二電極之間且包含碳奈米管的電阻式切換材料層。
Patent TW-202326968-A (TW)
Title: 為了減小封裝高度而採用中介層將上部堆疊式晶粒耦合至封裝基板的堆疊式晶粒積體電路（ｉｃ）封裝以及相關製造方法
Inventor: VEMURI KRISHNA
IPC: H01L23/31
Filed: 2022-07-01
Abstract: 為了減小封裝高度而採用中介層將（諸）上部堆疊式晶粒電耦合至封裝基板的堆疊式晶粒積體電路（IC）封裝，以及相關製造方法。為了降低IC封裝的高度且同時提供要電耦合至封裝基板的堆疊式晶粒，該IC封裝包括中介層。該等堆疊式晶粒被設置在該封裝基板與該中介層之間。一或多條導線耦合（例如，導線接合）在上部晶粒與中介層之間，以提供該上部晶粒與該中介層之間的電連接。一或多個電互連（例如，導電柱）耦合在該中介層與該封裝基板之間，以在該上部晶粒與該封裝基板之間路由電連接。因此，該上部晶粒可電耦合至該封裝基板，而不要求該上部晶粒上方用於導線接合的附加淨空區域。
Patent TW-202319151-A (TW)
Inventor: HAN GYU-BONG
IPC: B23F11/00
Filed: 2022-07-11
Abstract: The present invention relates a janggu shaped worm shaft processing device, comprising: a substrate having a main shaft for rotating a processed object having a janggu shaped body, and a tailstock for fixing the processed object to the main shaft; a rotation unit having a rotation plate configured to perform left or right rotation and the substrate is installed its upper surface; an arranging mean capable of moving the substrate along front-back and left-right direction, so that the rounded cutting surface of the janggu shaped body is configured to form concentric circles with a rotational path of the rotation plate with a center point of the rotation plate as a reference; and a cutter fixed on a center side of the rotation plate, so as to toward the rounded cutting surface of the janggu shaped body; the processed object may realize thread processing in the janggu shaped worm shaft by orbital revolution around the cutter.
Patent TW-202324078-A (TW)
Title: Operating a secure code segment on a processor core of a processing unit
Inventor: LICHTENAU CEDRIC
IPC: G06F9/06
Filed: 2022-07-19
Abstract: A computer-implemented method, a computer system and a computer program product operate a secure code segment on a processor core of a processing unit, wherein the processing unit is configured with at least one processor core. The method comprises requesting exclusive secure execution of a secure code segment of the program code on the at least one processor core. The method also comprises setting the at least one processor core to exclusive secure execution for the secure code segment. The method further comprises executing the secure code segment on the at least one processor core uninterruptably. In addition, the method comprises wiping an architected state and a non-architected state of a physical processor core from the at least one processor core. Lastly, the method comprises setting the at least one processor core to the first execution mode for executing program code on the at least one processor core.
Patent TW-202314349-A (TW)
Title: Color conversion member, light source unit including same, display, and illumination device
Inventor: SAKAINO HIROTOSHI
IPC: G02F1/13357
Filed: 2022-09-14
Abstract: A color conversion member according to an embodiment of the present invention converts incident light into light having a wavelength different from that of the incident light, and includes at least a layer (A) and a layer (B), which are described below. The layer (A) is a color conversion layer containing at least one organic light-emitting material that emits delayed fluorescence, and a binder resin. The layer (B) has an oxygen permeability of at most 1.0 cc/m2.day.atm.
Patent TW-202328361-A (TW)
Title: Inkjet ink for partition wall formation, inkjet ink set for partition wall formation, and led device manufacturing method
Inventor: HATTORI TAKAMUNE
IPC: C09D11/30
Filed: 2022-09-27
Abstract: The present invention addresses the problem of providing: an inkjet ink for partition wall formation and an inkjet ink set for partition wall formation that make it possible to form, with low damage, a partition wall which does not decrease luminance, the partition wall being formed between LED chips; and an LED device manufacturing method using the foregoing. This inkjet ink for partition wall formation is used for forming a partition wall between LED chips in an LED device, and is characterized by: including a photopolymerizable composition and a colorant; and containing 25% or less of a solvent having a standard boiling point of 250 DEG C or lower.
Patent TW-202327873-A (TW)
Title: Multilayer structure including insulating layer
Inventor: ARAI TORU
IPC: B32B15/08
Filed: 2022-10-14
Abstract: Provided is a multilayer structure comprising one or more insulating layers, one or more resin layers, and one or more sheets of copper foil that has a smooth surface and a roughened surface, said multilayer structure being characterized in that: the insulating layers contain an olefin-aromatic vinyl compound-aromatic polyene copolymer and a surface modifying agent; the resin layers contain at least one selected from the group consisting of polyimide (PI), a liquid crystal polymer (LCP), polyphenylene ether (PPE), multifunctional aromatic vinyl resin (ODV), epoxy resin, and the composition of the insulating layers; at least one surface of each of the insulating layers is bonded to the smooth surface of the copper foil; and with regard to each of the resin layers, either at least one surface of the resin layer is bonded to the roughened surface of the copper foil and the resin layer is not bonded to the smooth surface of the copper foil, or neither surface of the resin layer is bonded to the copper foil.
Patent TW-202322635-A (TW)
Title: 網路交換器及電路板
Inventor: LEE KUAN-TSE
IPC: H04Q3/00
Filed: 2022-10-17
Abstract: 一種網路交換器，可包含高精度時間協定模組及電路板。該高精度時間協定模組可提供第一時脈訊號，且包含預定介面。該電路板可包含插槽、振盪器及選擇單元。該插槽可被該預定介面插入，以接收該第一時脈訊號。該振盪器可提供第二時脈訊號。該選擇單元可包含第一端、第二端、輸出端及選擇端。當該預定介面插入該插槽時，該第一端可接收該第一時脈訊號。該第二端可接收該第二時脈訊號。該輸出端可輸出該第一時脈訊號及該第二時脈訊號之一者。該選擇端可接收選擇訊號以控制該輸出端輸出該第一時脈訊號或該第二時脈訊號。
Patent TW-202318231-A (TW)
Title: 使用共同定位之輔助設備來防止憑證檔案盜用
Inventor: ISLES ADRIAN
IPC: G06F21/30
Filed: 2022-10-28
Abstract: 一種方法包含藉由一服務提供者平台接收來自一第一用戶端設備之一服務請求，及與該服務請求相關聯並由該第一用戶端設備產生之一鑑認符記之一第一例項。該服務提供者平台可進一步接收來自一第二用戶端設備之與該服務請求相關聯並由該第一用戶端設備產生之該鑑認符記之一第二例項。回應於判定該鑑認符記之該第一例項與該鑑認符記之該第二例項匹配，藉由該服務提供者平台處理該服務請求。
Patent TW-202333706-A (TW)
Title: Ｎ—羥基胞磷膽鹼（ｃｉｔｉｃｏｌｉｎｅ）化合物的醫藥用途
Inventor: GEGE CHRISTIAN
IPC: A61K31/495
Filed: 2022-11-01
Abstract: 本發明係關於具有N
         4 -羥基胞苷部分之胞磷膽鹼(citicoline)類似物及其溶劑化物或醫藥上可接受之鹽之醫藥用途。該等化合物可用作用於治療(例如) Covid-19、人鼻病毒(HRV)、流感及呼吸道融合性病毒(RSV)之抗病毒藥物。
Patent TW-202328039-A (TW)
Title: Salt, acid generator, resin, resist composition and method for producing resist pattern
Inventor: SHIMADA MASAHIKO
IPC: C07C43/225
Filed: 2022-11-03
Abstract: The present disclosure relates to a salt, an acid generator, a resin, a resist composition and a method for producing a resist pattern. The present disclosure relates to a salt represented by formula (I). The resist composition of the present disclosure can be prepared by mixing a salt represented by formula (I) or a resin, wherein, in formula (I), R4, R5, R7 and R8 each independently represent a halogen atom, a hydroxy group, X1 and X2 are each independently O or S, m1 represents an integer of 1 to 5, m2, m4, m5, m8 represents an integer of 0 to 5, m7 represents an integer of 0 to 4, in which 1 ≤ m1+m7 ≤ 5, 0 ≤ m2+m8 ≤ 5. Qb1 and Qb2 each independently represent a hydrogen atom, a fluorine atom. Lb1 represents a divalent saturated hydrocarbon group. Yb1 represents a single bond or an alicyclic hydrocarbon group. Rbb1 represents a hydrogen atom, a halogen atom. X10 represents a single bond, *-O-**. L10 represents a single bond or a hydrocarbon group.
Patent TW-202334403-A (TW)
Title: Modified arenavirus particles expressing mutant kras, mutated cancer driver gene, or tumor-associated antigen as cancer immunotherapies
Inventor: LAUTERBACH HENNING
IPC: C12N7/01
Filed: 2022-11-07
Abstract: The invention relates to genetically modified arenaviruses suitable for the treatment of neoplastic diseases, such as cancer. The arenaviruses described herein may be suitable for treatment of neoplastic diseases and/or for the use in immunotherapies. In particular, provided herein are methods and compositions for treating a neoplastic disease by administering a genetically modified arenavirus, wherein the arenavirus has been engineered to include a nucleotide sequence encoding one or more antigenic fragment(s) of mutant KRAS alone or to further include a nucleotide sequence encoding one or more antigenic fragment(s) of a mutated cancer driver gene (
         e.g. , a mutant TP53) or a tumor-associated antigen.