Patent SG-11201804405P-A (SG)
Title: Use of microrna-146a and nanoceria conjugate to improve wound healing and promote tissue regeneration
Inventor: LIECHTY KENNETH
IPC: C01F17/235
Filed: 2016-11-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau (43) International Publication Date ..... .....r .,„01 1 June 2017 (01.06.2017) WIPO I PCT ID Hit (10) 1111111111111111111 WO International Ell 2017/091700 11111111101 Publication 1111111111111111 Number Al RIO IIII IIIIIIII (51) International Patent Classification: lando, Florida 32826 (US). GORMAN, Robert; do Uni- A61K 9/51 (2006.01) C12N 15/113 (2010.01) versity of Pennsylvania, Penn Center for Innovation, 3160 A61K 33/24 (2006.01) Chestnut Street, Suite 200, Philadelphia, Pennsylvania 19104 (US). (21) International Application Number: PCT/US2016/063540 (74) Agents: EWING, James F. et al.; Foley & Lardner LLP, (22) International Filing Date: 3000 K. Street, N.W., Suite 600, Washington, District of 23 November 2016 (23.11.2016) Columbia 20007 (US). (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of national protection available): AE, AG, AL, AM, (26) Publication Language: English AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (30) Priority Data: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 62/259,909 25 November 2015 (25.11.2015) US HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 62/378,997 24 August 2016 (24.08.2016) US KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (71) Applicants . THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE [US/US]; OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 1800 Grant Street, 8th Floor, Denver, Colorado 80203 SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (US). UNIVERSITY OF CENTRAL FLORIDA RE- SEARCH FOUNDATION, INC. [US/US]; 12201 Re- ZW. search Parkway, Ste 501, Orlando, Florida 32826 (US). (84) Designated States (unless otherwise indicated, for every THE TRUSTEES THE OF UNIVERSITY OF kind of regional available): ARIPO (BW, GH, protection PENNSYLVANIA [US/US]; Penn Center for Innovation, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 3160 Chestnut Street, Suite 200, Philadelphia, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Pennsylvania 19104 (US). TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors: LIECHTY, Kenneth; 12631 E. 17th Avenue, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Aurora, Colorado 80045 (US). SEAL, Sudipta; Uni- c/o SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, versity of Central Florida, 12201 Research Parkway, Or- GW, KM, ML, MR, NE, SN, TD, TG). [Continued on next page] Title: MICRORNA-146A AND NANOCERIA TO IMPROVE WOUND HEALING AND PROMOTE (54) USE OF CONJUGATE TISSUE REGENERATION 120 -- o Non-Db + PBS __a_- Db + PBS as ---&-- Non-Db + CNPs-miR-146a 2 0 —0-- Db + CNPs-miR-146a < v C = ''' C 6 0 z 0 1-1 0 0 ‘ \ JI b - _ 0 0 IN DO D2 D4 D5 D7 D9 D1D D12 D14 D16 D19 D21 1-1 Days 01 0 HG. 30 N 1-1 O (57) : The present disclosure relates to wound treatment and therapy and the promotion of tissue regeneration following in - \" jury. In particular, it relates to a microRNA-146a and nanoceria conjugate for improving wound healing and, in some embodiments, 0 preventing adverse ventricular remodeling following myocardial infarction. WO 2017/091700 Al MIDEDItitiDEIRDEFEDIEREDIDENIMMIEDIS Declarations under Rule 4.17: Published: — as to the applicant's entitlement the earlier application (Rule 4.17 to claim (iii)) the priority of — with international search report (Art 21(3))