baber/WOPTO huggingface dataset:
Patent EA-013535-B1 (EA)
Title: Polymer conjugate of bioactive component (variants), method for producing and use thereof, pharmaceutical products on the base thereof
Inventor: BHASKARAN SHYAM S
IPC: A61K47/48
Filed: 2003-12-23
Abstract: Methods are provided for the synthesis of polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and receptor-binding antagonists thereof, which conjugates retain unusually high receptor-binding activity. Producing the polymer conjugates according to the methods of the present invention reduces to a minimum or allows to avoid steric inhibition of receptor-ligand interactions that commonly results from the attachment of polymers to receptor-binding regions of cytokines, chemokines, growth factors and polypeptide hormones, as well as to agonistic and antagonistic analogs thereof. The invention also provides conjugates and compositions produced by such methods. The conjugates of the present invention retain a higher level of receptor-binding activity than those produced by the traditional polymer coupling methods that are not targeted to avoid receptor-binding domains of cytokines, chemokines, growth factors and polypeptide hormones. The conjugates of the present invention also exhibit an extended half-life in vivo and in vitro compared to unconjugated cytokines, chemokines, growth factors and polypeptide hormones. The present invention also provides kits comprising such conjugates and/or compositions, and the methods for the use of such conjugates and compositions in a variety of diagnostic, prophylactic, therapeutic and bioprocessing applications.
Patent EA-012064-B1 (EA)
Title: Cationic starches of legume origin and application methods thereof
Inventor: LADRET MARIKA
IPC: C08B31/12
Filed: 2004-05-11
Abstract: The invention relates to a novel solvent-free method for the cationisation of a legume starch and aqueous compositions based thereon. The invention further relates to the use of the cationic starches or compositions based thereon in the paper industry and, in particular, in the wet end of a paper-making machine, as retention agent, dewatering agent and/or for improving the physical characteristics of paper, and also as an agent for reducing interfering substances contained in water circuits and/or retained on process equipment. Finally, the invention relates to the folding carton or paper thus obtained, containing at least one cationic starch originating from legumes or compositions based thereon.
Patent EA-011120-B1 (EA)
Title: Acoustic panel and manufacturing method
Inventor: MERES OSKAR
IPC: E04B1/84
Filed: 2006-03-17
Abstract: An acoustic panel (1) has a recess (8) extending part or all way down to a facing (7). A panel loudspeaker (11) may be fixed in the recess or a water sprinkler (14) or other device may be mounted in or above the recess.
Patent EA-013007-B1 (EA)
Title: Method for producing hop leaven for baking nonyeasted bread, hop leaven therefor and method for baking nonyeasted bread based thereon
Inventor: GOLEVA RAISA NIKOLAEVNA
IPC: A21D2/36
Filed: 2007-12-19
Abstract: The invention relates to the food manufacturing industry, in particular to the breadbaking, and namely to a method of production of the scalded nonyeasted rye and mixed rye-wheat bread. The invention relates to a method of production of a hop leaven for nonyeasted bread, wherein the leaven is produced in four stages, a brew being prepared at the first stage by mixing 30-35% of formulation quantity for the leaven of medium rye flour and water having temperature of 90-95ºC with addition of a hop component in the form of a dry hop composition at the ratio of medium rye flour, water and hop composition 1:(2.0-2.5):(0.012-0.014) with the subsequent brew cooling up to 65-68ºC, the brew being saccharified at the second stage at the temperature of 65-68ºC for about 20 min, a batter being prepared at the third stage by mixing the rest formulation quantity for the leaven of medium rye flour and water having temperature of 28-30ºC at the ratio of medium rye flour and water about 1:(1-1.5), and the saccharified brew and the batter being mixed at the fourth stage with the subsequent mixture cooling up to 16-18ºC till production of the hop leaven having moisture of 80-82% and acidity of 6-8 grad, the second and the third stages being accomplished simultaneously. The invention further relates to the hop leaven, produced by the said method and a method of production of nonyeasted bread on the base of the said leaven.
Patent EA-013850-B1 (EA)
Title: Mobile energy device
Inventor: DJUZHEV ANDREJ ANISIMOVICH
IPC: A01B51/02
Filed: 2008-01-28
Abstract: A mobile energy device includes an internal combustion engine, a drive wheels bridge and the hydromechanical transmission. The transmission includes a gearbox, a reversing adjustable hydraulic pump, which shaft is connected with a shaft of the internal combustion engine, a reversing hydraulic motor, which working cavities are connected with the working cavities of the reversing adjustable hydraulic pump by the supply lines, a reversing reduction gear, a frictional clutch, as well as a planetary adder, which sun and ring gears are kinematically connected with the shaft of the reversing hydraulic motor and the shaft of the internal combustion engine respectively, and a carrier is kinematically connected with the gearbox. The hydromechanical transmission is provided with a shift mechanism. The ring gear is kinematically connected with the shaft of the internal combustion engine through the reversing reduction gear and the frictional clutch. The sun gear is kinematically connected with the shaft of the reversing hydraulic motor through the shift mechanism mounted with the possibility of alternate connection of the shaft of the reversing hydraulic motor with the sun gear or with the sun gear and the carrier simultaneously. The shift mechanism can be made in the form of a controllable clutch.
Patent EA-021501-B1 (EA)
Title: Lipoic acid pellets
Inventor: BOLTRI LUIGI
IPC: A23L33/00
Filed: 2007-05-25
Abstract: The present invention relates to formulations based on lipoic acid or its analogs. 1,2-Dithiolan-3-pentanoic acid (generally known as lipoic or thioctic acid), is an active principle with antioxidant activity which is used for the treatment of some diseases, including liver and biliary diseases, polyneuropathies, diabetic polyneuropathies, viral infections, hypercholesterolemia, dyslipidemia, renal diseases, Alzheimer's disease, tumor pathologies, etc. This compound promotes metabolism and is used as support in some pharmacological treatments or therapies, as for instance in chemotherapy or in patients subjected to cycles of hemodialysis, or in patients undergoing detoxifying treatment (detoxication). The present invention is aimed at using a pellet for preparing a medicament useful for the treatment of pathological conditions responsive to lipoic acid treatment and also using these pellets as a nutritional (foodstuff) supplement and for preparing the same. The present invention describes the lipoic acid pellets composed of inert cores coated with lipoic acid (active cores) and further coated with a first polymeric coat with insulating function and then with a second polymeric coat and also different embodiments of preparation and formulation thereof. The invention is also aimed at formulations (compositions) used as foodstuffs. The lipoic acid pellets can be used in food industry as nutritional supplements as additives for a certain foodstuff, for example, the foodstuff having an acid pH.
Patent EA-017775-B1 (EA)
Title: Beta-amino acid derivatives for treatment of diabetes
Inventor: BENDER STEFAN
IPC: A61K31/4155
Filed: 2008-12-23
Abstract: Novel heterocyclic compounds of the Formula (I)in which R, R, R', R'', R, R, R, R, Rand Rhave the meanings indicated in Claim 1, are activators of glucokinase and can be used for the prevention and/or treatment of Diabetes Type 1 and 2, obesity, neuropathy and/or nephropathy.
Patent EA-029890-B1 (EA)
Title: Pharmaceutical composition and pharmaceutical composition in oral dosage form based on dpp iv inhibitor
Inventor: KOHLRAUSCH ANJA
IPC: A61K38/095
Filed: 2007-04-30
Abstract: The invention relates to a pharmaceutical composition comprising as an active ingredient a DPP IV inhibitor which is 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)xanthine, or a salt thereof, a first diluent, a second diluent, a binder, a disintegrant and a lubricant disclosed in the claims, and to a process for the preparation thereof. The invention also relates to a pharmaceutical composition in an oral dosage form comprising as an active ingredient a DPP IV inhibitor which is 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)xanthine, a first diluent, a second diluent, a binder, a disintegrant and a lubricant disclosed in the claims.
Patent EA-021399-B1 (EA)
Title: Method of identifying disease risk factors
Inventor: ROSES ALLEN D
IPC: G01N33/50
Filed: 2009-08-11
Abstract: Provided herein is a method for identifying a genetic variant that is associated with development of a condition of interest (e.g., Alzheimer's disease), and genetic variants so identified. Methods of treatment with an active agent (e.g., with a particular active agent and/or at an earlier age) is also provided, upon detecting a genetic variant described herein. In some embodiments, the genetic variant is a deletion/insertion polymorphism (DIP) of the TOMM40 gene. Kits for determining if a subject is at increased risk of developing late onset Alzheimer's disease is also provided. Kits for determining if a subject is responsive to treatment for a condition of interest with an active agent are further provided.
Patent EA-024397-B1 (EA)
Title: New ccr2 receptor antagonists and uses thereof
Inventor: EBEL HEINER
IPC: C07D491/10
Filed: 2010-12-13
Abstract: The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) of Formula (I) and their use for providing medicaments for treating pathological conditions and diseases, especially pulmonary diseases like asthma and COPD.
Patent EA-025116-B1 (EA)
Title: Process of supplying water of controlled salinity
Inventor: WILLIAMS JOHN DALE
IPC: C02F1/44
Filed: 2011-01-11
Abstract: The invention provides a process of producing an injection water stream of controlled salinity and controlled sulfate anion content that is suitable for injection into an oil bearing formation of an oil reservoir, the process comprising the steps of: a) feeding a source water (SW) having a total dissolved solids (TDS) content in the range of 20,000 to 45,000 ppm and a sulfate anion concentration in the range of 1,000 to 4,000 ppm, to a desalination plant that comprises a plurality of reverse osmosis (RO) membrane units and a plurality of nanofiltration (NF) membrane units, wherein the source water is pressurised to a pressure in the range of 2.41-8.62 MPa absolute, and dividing the source water to provide a feed water for the RO membrane units (hereinafter "RO feed water") and a feed water for the NF membrane units (hereinafter "NF feed water"); b) increasing the pressure of the RO feed water to a value in the range of 6.21-8.62 MPa absolute before introducing the RO feed water to the RO membrane units if the pressure of the RO feed water separated from the SW is lower than 6.21 MPa absolute, and withdrawing an RO permeate and an RO retentate from the RO membrane units wherein the RO membrane units are operated in either a single-pass, single-stage mode or in a single-pass, two-stage mode and wherein the recovery of RO permeate is in the range of 35 to 75% by volume, based on the volume of the RO feed water that is fed to the RO membrane unit, such that the RO permeate has a TDS content of less than 250 ppm, and a sulfate anion concentration of less than 3 ppm; c) reducing the pressure of the NF feed water to a value in the range of 2.41-3.10 MPa absolute before introducing the NF feed water to the NF membrane units, if the pressure of the NF feed water separated from the SW is higher than 3.10 MPa absolute, and withdrawing an NF permeate and an NF retentate from the NF membrane units, wherein the NF membrane units are operated in a single-pass, single-stage mode and wherein the NF membrane units are operated with a recovery of NF permeate in the range of 35 to 60% by volume based on the volume of the NF feed water that is fed to the NF membrane unit, such that the NF permeate has a TDS content in the range of 15,000 to 40,000 ppm, and a sulfate anion concentration of less than 40 ppm; and d) mixing at least a portion of the RO permeate and at least a portion of the NF permeate in a ratio in the range of 2:1 to 40:1 in a mixing point to provide an injection water having a TDS content in the range of 500 to 5,000 ppm, and a sulfate anion concentration of less than 7.5 ppm, wherein the pressure of the NF permeate is maintained at least 34.5 kPa higher than the pressure of the RO permeate by means of a back pressure valve that is provided upstream of the mixing point for the NF permeate and RO permeate and wherein the NF permeate is injected into the RO permeate at the mixing point to form the injection water.
Patent EA-029505-B1 (EA)
Title: Compositions based on clay and bee pollen, method for preparing same, and nutritional and therapeutic uses thereof
Inventor: FREGONESE ALEXANDRA
IPC: A23L33/00
Filed: 2011-12-14
Abstract: The present invention relates to biologically active complexes of clay and of bee pollen, comprising from 4 to 90% of bee pollen and from 10 to 96% of clay, the percentages being understood by weight; and having a humidity level of less than 15%, and also to the method for preparing same and to the uses thereof in therapy or as a food supplement, functional food, in human and animal healthcare.
Patent EA-025840-B1 (EA)
Title: Pyrazine derivatives as cannabinoid receptor 2 agonists
Inventor: DHURWASULU BALEDI
IPC: C07D403/14
Filed: 2013-12-04
Abstract: The invention relates to a compound of formula (I) wherein Rto Rare defined as in the description and in the claims. The compound of formula (I) is a CB2 receptor agonist for use in the treatment of several disorders, such as pain, atherosclerosis and glaucoma.
Patent EA-033245-B1 (EA)
Title: System and process for feeding longitudinal wire or rods to mesh producing machines
Inventor: ANAGNOSTOPOULOS ANTONIOS
IPC: B21F27/10
Filed: 2015-03-31
Abstract: The invention relates to systems and processes for feeding longitudinal wires in a mesh (3) production machine. Mesh (3) is produced by the welding of longitudinal wires (2) with transverse wires (6) at a welding unit (27). The longitudinal wires may be pulled from decoder reel (40), straightened, and then deposited in longitudinals storage (19). They are then received by a longitudinals carrier (15) and transported towards welding unit (27). The longitudinal wires (2) are selectively rotated around their longitudinal axes with selected angle, and restrained until their welding with the transverse wires. This negates effects of any possible curvature acquired during their straightening with rollers (9), so that after their welding, the resulting mesh (3) is produced planar with the distortion stresses neutralized.
Patent EA-031674-B1 (EA)
Title: IMIDAZO[4,5-c]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER
Inventor: BARLAAM BERNARD CHRISTOPHE
IPC: C07D471/04
Filed: 2015-05-05
Abstract: This invention generally relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, where Q, R, R, R, Rand Rhave any of the meanings defined herein. The invention also relates to the use of such compounds and salts thereof to treat or prevent ATM (ataxia telangiectasia mutated) kinase mediated disease, including cancer. This invention further relates to crystalline forms of compounds of imidazo[4,5-c]quinolin-2-one compounds and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds and salts; kits comprising such compounds and salts; methods of manufacture of such compounds and salts; intermediates useful in the manufacture of such compounds and salts; and to methods of treating ATM kinase mediated disease, including cancer, using such compounds and salts.
Patent EA-036680-B1 (EA)
Title: Disinfection system
Inventor: CAJAUSKIS SAULIUS
IPC: B01D53/34
Filed: 2017-01-25
Abstract: A disinfection system comprising at least one ozone generator (5, 18) and an ozone detector (6) in a room (3) to be disinfected. The room (3) is connected to a vent opening (1, 2) for discharging air from said room (3). The system includes a presence detector (14) for detecting persons within said room (3), a programmable timer (10), a central controller (13) for managing at least one ozone generator (5, 18) in accordance with a set ozone level and a signal from the presence detector (14), a controller (11) for receiving signals from system detectors (6, 7, 9, 14), exchanging date with the central controller (13), receiving control signals from the central controller (13) and connecting with at least one ozone generator (5, 18). The system also comprises an ozone detector (7) in the vent opening (1, 2) and an airflow detector (9) in the vent opening (1, 2). The ozone detector (6) in the room (3) to be disinfected is installed at such a distance from at least one ozone generator (5, 18) that ozone could mix with air in the room (3) before reaching by generated ozone the ozone detector (6) in the room (3). Also provided is a method for controlling ozone in a room to be disinfected.
Patent EA-037897-B1 (EA)
Title: Smoking system, power supply control method and program, primary device and secondary device
Inventor: NAKANO TAKUMA
IPC: A24F40/95
Filed: 2017-03-13
Abstract: A smoking system that smoothly switches between a charge mode and a direct heating mode is provided with: a secondary device with a load for atomizing an aerosol source or heating a flavor source and a power source capable of supplying power to the load; a primary device which, when connected to the secondary device, is capable of supplying power to the load and the power source; and a control unit capable of executing a first mode in which the power is supplied from the primary device to the load and a second mode in which the power is supplied from the primary device to the power source. During a first transition, which is from the first mode to the second mode, and/or a second transition, which is from the second mode to the first mode, the control unit executes, in a time between the modes, a transition mode involving a transition time for changing a preset variable relating to power supply.
Patent ES-2177385-B1 (ES)
Title: Sistema de guiado para fotocoagulacion con laser de membranas neovasculares subretinianas.
Inventor: JANEZ ESCALADA LUIS
IPC: A61B3/14
Filed: 2000-03-21
Granted: 2004-08-16
Abstract: Sistema de guiado para fotocoagulación con láser de membranas neovasculares subretinianas. Sistema para aumentar la precisión en la localización de los puntos en el plano de la retina que han de ser fotocoagulados con láser. Permite marcar los puntos a fotocoagular sobre la angiografía de la coroides con verde de indocianina, en la que son fácilmente identificables, y el sistema traslada automáticamente esos puntos a la imagen de retinografía, donde resulta difícil localizarlos, pero es la que el oftalmólogo observa cuando tiene que situar el láser para efectuar la fotocoagulación. El sistema consiste en un servidor (1), un canal de comunicaciones (2) y uno o varios ordenadores de usuario (3). El servidor contiene un programa, que con técnicas matemáticas y de tratamiento digital de imágenes, traslada a la retinografía los puntos a fotocoagular que el oftalmólogo había marcado en la angiografía. Constituye un servicio que puede ser utilizado en local o a través de internet.
Patent ES-2165826-B1 (ES)
Title: Estructura para estanterias desmontables
Inventor: PASCUAL CAPELL AUREA
IPC: F16S3/00
Filed: 2000-11-27
Granted: 2003-10-16
Abstract: Mejoras en el objeto de la patente principal n° 9700413, por "estructura para estanterías desmontables". Comprende una pluralidad de perfiles huecos (1) en forma de T, abiertos por la base de dicha T a modo de puntales, los cuales comprenden una pluralidad de orificios (2) a lo largo de toda su longitud, comprendiendo además dicha estructura, paneles (3) unidos a dichos puntales a modo de bandejas, una pluralidad de travesaños dispuestos entre cada dos puntales, medios de arriostramiento, medios de unión entre dos estanterías, y retenedores traseros (4) de paneles (3), los cuales se acoplan a la estructura por apoyo directo y sin necesidad de tornillería, y se caracterizan por el hecho de que los retenedores traseros (4) comprenden un par de salientes de sujeción (5) que encajan en unos orificios complementarios (6) situados en la parte inferior de los paneles (3), reforzando de este modo las paredes de dichos paneles (3) que se encuentran separadas mediante sendas aberturas (7) en sus esquinas.
Patent ES-2192938-B1 (ES)
Title: Remate superior para chimeneas con salida de gases no solo lateral, sino tambien superior.
Inventor: LOPEZ ESCRIBANO MARIA PAZ
IPC: F23L17/08
Filed: 2001-06-04
Granted: 2005-02-16
Abstract: Remate superior para chimeneas con salida de gases no solo lateral, sino también superior. Se trata de un deflector para chimeneas (CH) donde no solo las paredes laterales (D) están compuestas por lamas, sino que también su plano superior contiene lamas (B), de modo que el tejadillo (A) está en la parte central de dicho plano y una serie de lamas (B) cierran el espacio entre el tejadillo y las paredes laterales, dichas lamas tienen la misma inclinación que las que componen las paredes laterales a las que se acercan, en el interior otra lama (C) impide la entrada de lluvia.
Patent ES-2233132-B1 (ES)
Title: Piscina fuera del suelo cubrible.
Inventor: MARBACH GERARD
IPC: E04H4/10
Filed: 2002-07-31
Granted: 2006-03-16
Abstract: Piscina fuera del suelo cubrible que tiene un borde desbordante y cubrible con una cubierta: la cubierta plegada, eventualmente encerrada en una bolsa, está enganchada en un primer emplazamiento; después es desplegada y tirada por encima de la piscina sucesivamente a una parte y otra de ésta y es enganchada sucesivamente en dos puntos tales que una línea que une estos dos puntos esté situada a longitud de brazo de un cuarto punto opuesto al primer punto; se acaba de tirar desde el punto donde unos medios de atado que pasan periféricamente bajo el borde son anudados.
Patent ES-2249154-B1 (ES)
Title: Bolsa no-pesa.
Inventor: MORA-GRANADOS ESTEBAN MARIA DE
IPC: B65D33/06
Filed: 2004-07-13
Granted: 2007-05-16
Abstract: Bolsa de plástico para transporte de alimentos y otros productos, adquiridos en supermercados, tiendas, etc. provista de dos asas largas y almohadilladas, ya sea por medio de burbujas de aire, gomaespuma, caucho, etc. con la característica exclusiva de disponer de asas largas y almohadilladas o acolchadas y de haber sido diseñada específicamente para llevar colgada del hombro, evitando así que el peso de los artículos a transportar en la misma sea infringido sobre brazos y manos y así mismo permitiendo la movilidad plena de los mismos.
Patent ES-2223306-B1 (ES)
Title: Muelle de gas.
Inventor: CARCARE GIMENO MANUEL
IPC: F16F9/08
Filed: 2004-08-26
Granted: 2005-12-16
Abstract: Muelle de gas. Muelle de gas, del tipo que comprende un cilindro lleno de un gas y un émbolo, caracterizado porque el cilindro presenta interiormente una primera y una segunda cámara separadas por una membrana flexible. La primera cámara está ocupada por un gas compresible y la segunda cámara de un líquido con propiedades lubricantes. La segunda cámara ocupa la zona de entrada del émbolo en el interior del cilindro, de tal manera que en su recorrido de entrada en el cilindro, el émbolo desplaza el fluido con propiedades lubricantes de la segunda cámara, el cual a su vez deforma la membrana de separación entre cámaras y comprime el gas de la primera cámara.