Patent SG-11201810294Q-A (SG)
Title: Treatment for parkinson's disease
Inventor: DAMLE NITIN KRISHNAJI
IPC: A61K31/44
Filed: 2017-06-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1 MI 11111 0 11101 HOE 010 1111 1 0 01010 HEM OH 100 1111 1111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date . . .., . .. WO 2017/208267 Al 07 December 2017 (07.12.2017) WIP0 I PCT (51) International Patent Classification: ited, Sun Pharma Advanced Research Centre, Nima Corn- A61K 31/44 (2006.01) A61P 25/16 (2006.01) pound, Near Pratham Enclave, Tandalja Road, Gujarat, Bar- A61K 31/47 (2006.01) oda 390020 (IN). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/IN2017/050224 kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 02 June 2017 (02.06.2017) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (26) Publication Language: English KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (30) Priority Data: PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, 201621019087 02 June 2016 (02.06.2016) IN SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, 201621019185 02 June 2016 (02.06.2016) IN TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: SUN PHARMA ADVANCED RESEARCH (84) Designated States (unless otherwise indicated, for every COMPANY LIMITED [IN/IN]; 17/B, Mahal Industrial kind of regional protection available): ARIPO (BW, GH, Estate, Mahakali Caves Road, Andheri (E), Mumbai 400093 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (IN). UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (72) Inventors: DAMLE, Nitin Krishnaji; Sun Pharma Ad- EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, vaned Research Company Limited, Sun Pharma Advanced MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Research Centre, Nima Compound, Near Pratham Enclave, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Tandalja Road, Gujarat, Baroda 390020 (IN). MAND-KM, ML, MR, NE, SN, TD, TG). — = HANE, Sanjay Nandlalji; Sun Pharma Advanced Re- _ search Company Limited, Sun Pharma Advanced Research Declarations under Rule 4.17: Centre, Nima Compound, Near Pratham Enclave, Tandalja — as to applicant's entitlement to apply for and be granted a Road, Gujarat, Baroda 390020 (IN). UPADHYA, Manoj patent (Rule 4.17(ii)) Atmaramji; Sun Pharma Advanced Research Company — of inventorship (Rule 4.17(iv)) Limited, Sun Pharma Advanced Research Centre, Nima _ = Compound, Near Pratham Enclave, Tandalja Road, Gu- Published: jarat, Baroda 390020 (IN). MEHETRE, Sameer Vish- — with international search report (Art. 21(3)) — = wanath; Sun Pharma Advanced Research Company Lim- — before the expiration of the time limit for amending the = ited, Sun Pharma Advanced Research Centre, Nima Com- claims and to be republished in the event of receipt of = pound, Near Pratham Enclave, Tandalja Road, Gujarat, Bar- amendments (Rule 48.2(h)) oda 390020 (IN). CHIDREWAR, Gajanan Uttamrao; = = Sun Pharma Advanced Research Company Limited, Sun = Pharma Advanced Research Centre, Nima Compound, Near _ Pratham Enclave, Tandalja Road, Gujarat, Baroda 390020 = (IN). SENGUPTA, Prabal; Sun Pharma Advanced Re- = search Company Limited, Sun Pharma Advanced Research = — Centre, Nima Compound, Near Pratham Enclave, Tandalja = Road, Gujarat, Baroda 390020 (IN). CHITTURI, Trinad- - = ha Rao; Sun Pharma Advanced Research Company Lim- - ,_ 1 (54) Title: TREATMENT FOR PARKINSON'S DISEASE (57) : The invention relates to a method of treating or preventing IN Parkinson's disease in a subject comprising administering a compound of Formula 1 N R3 R4 I wherein, R1 is —NHC(0) C3_6 cycloalkyl and R2 is hydrogen; or R1 and R2 along c3 C R -r\ . % with the carbon atoms to which they are attached form a six membered aromatic C Z el NH 1 „, ring, wherein the ring is substituted with one or more groups selected from hydrogen, 0 NH 'ir . ' , \"' -- halogen and C1_6 alkyl; R3 and R4 are independently selected from group comprising IN o Il hydrogen, halogen, C1_3 alkyl, OCi_3 alkyl, NO2, SC _3 alkyl, C1_3 haloalkyl, 0C1-3 © Formula I haloalkyl, and SC haloalkyl; or a pharmaceutically acceptable salt thereof. 1 _ 3 N C