Patent SG-11201805954W-A (SG)
Title: Methods for modulating intestinal microbiota
Inventor: NORDKILD PETER
IPC: C07K14/47
Filed: 2017-01-26
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 11111111011110111010101111101011111011101110111111110111111111101111101111011111 International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ..... .....!;,' WO 2017/129195 Al 3 August 2017 (03.08.2017) WI P0 I P CT (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 38/00 (2006.01) CO7K 14/47 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, A61K 38/17 (2006.01) A23L 33/00 (2016.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (21) International Application Number: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, PCT/DK2017/050017 MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (22) International Filing Date: NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 26 January 2017 (26.01.2017) RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (25) Filing Language: English ZA, ZM, ZW. (26) Publication Language: English (84) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of regional protection available): ARIPO (BW, GH, PA 2016 70041 26 January 2016 (26.01.2016) DK GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, PA 2016 70483 1 July 2016 (01.07.2016) DK TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (71) Applicant: DEFENSIN THERAPEUTICS APS DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, [DK/DK]; c/o COBIS, Ole Maaloesvej 3, 2200 Copenha- LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, gen (DK). SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (72) Inventors: NORDKILD, Peter; Veldegardsvej 59, 2820 GW, KM, ML, MR, NE, SN, TD, TG). Gentofte (DK). WEHKAMP, Jan; Hohenzollernstrasse Declarations under Rule 4.17: _ 16, 72766 Reutlingen (DE). KVERULFF, Soren; Clarks- — of inventorship (Rule 4.17(N)) vej 6, 2840 Holte (DK). = Published: (74) Agent: HOIBERG P/S; Adelgade 12, 1304 Copenhagen _ — international 21(3)) = K (DK). with search report (Art. — with sequence listing part of description (Rule 5.2(a)) (81) Designated States (unless otherwise indicated, for every kind AE, AG, AL, AM, of national protection available): = = = = = = = = = 1-1 ir) 01 Il 01 ei ,-1 (54) Title: METHODS FOR MODULATING INTESTINAL MICROBIOTA 1-1 C (57) : The present invention relates to methods for modulating the intestinal microbiota by administering one or more de- e , ' fensins and/or GLP-1/GLP-1 analogs and methods for prevention or treatment of gut inflammation by oral administration of one or O more defensins. GLP-1 analogs such as Liraglutide, as well as mammalian and poultry alfa and beta defensins can cause a change in ,-t the composition of the microbiota and metabolome in the intestine and can therefore be used to treat or prevent gut inflammation, colorectal cancer, metabolic syndrome, obesity, prediabetes and diabetes or as lean growth promoters in the meat production.