baber/WOPTO huggingface dataset:
Patent ES-2206997-T3 (ES)
Inventor: ARNOLD LEE D
IPC: A61P1/04
Filed: 1998-10-06
Granted: 2004-05-16
Abstract: Chemical compounds that are derivatives of indeno[1,2-c]-, naphtho[1,2-c]- and benzo[6,7]cyclohepta[1,2-c]pyrazole are inhibitors of tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in hyperproliferative, angiogenic or in vascular hyperpermeability processes. Thus, these chemical compounds can ameliorate disease states where tumor formation, metastasis, angiogenesis, vascular hyperpermeability or endothelial cell proliferation is a factor.
Patent ES-2200392-T3 (ES)
Title: Esfera o acumulador de membranas, por ejemplo, para suspension hidroneumatica de vehiculo automovil.
Inventor: DARROUX JEAN-LUC
IPC: F15B1/10
Filed: 1998-11-30
Granted: 2004-03-01
Abstract: LA PRESENTE INVENCION SE REFIERE A UNA ESFERA PARTICULARMENTE NEUMATICA. ESTA ESFERA COMPRENDE UNA ENVOLTURA RIGIDA (1) Y UNA MEMBRANA FLEXIBLE DEFORMABLE (2) COLOCADA DENTRO DE ESTA ENVOLTURA PARA DEFINIR UNA CAMARA SUPERIOR (4) Y UNA CAMARA INFERIOR (5), COMPRENDIENDO LA ESFERA EN LA CAMARA SUPERIOR (4), MEDIOS (6, 7, 8) ASOCIADOS CON LA ENVOLTURA (1) O CON LA MEMBRANA (2) PARA PERFORAR LA MEMBRANA (2), EN CASO DE PRESION EXCESIVA, EN LA CAMARA INFERIOR (5) Y, DE ESTE MODO, REDUCIR LA PRESION EN ESTA CAMARA.
Patent ES-2255193-T3 (ES)
Inventor: GUNTHER ULRICH
IPC: A61K9/16
Filed: 1998-10-16
Granted: 2006-06-16
Abstract: The invention relates to new, in particular orally administered pharmaceutical preparations containing, as pharmaceutical agent, pentaerythritol tetranitrate (PETN) or its metabolites pentaerythritol trinitrate, pentaerythritol dinatrate and pentaerythrito mononitrate, in amounts which guarantee the patient a sufficient dosage with one administering (per day).
Patent ES-2294828-T3 (ES)
Title: Procedimiento de ataque quimico textual piramidal por via humeda de superficies de silicio.
Inventor: HOLDERMANN KONSTANTIN
IPC: H01L31/0236
Filed: 1999-03-12
Granted: 2008-04-01
Abstract: LA PRESENTE INVENCION DESCRIBE UN PROCEDIMIENTO PARTA GRABADO AL ACIDO EN TEXTURA PIRAMIDAL DE QUIMICA HUMEDA DE SUPERFICIES DE SILICIO (100). A TRAVES DE LA SOLUCION DE ACUERDO CON LA INVENCION SE OBTIENE UN GRABADO AL ACIDO DE TEXTURA PIRAMIDAL REGULAR Y PERFECTO DE SUPERFICIES DE SILICIO.
Patent ES-2216375-T3 (ES)
Title: Interruptor termico, en particular regulador de temperatura ajustable.
Inventor: SCHWARZE MANFRED
IPC: H01H37/38
Filed: 1999-05-28
Granted: 2004-10-16
Abstract: UN REGULADOR DE TEMPERATURA QUE TRABAJA CON UNA CAJA DE DILATACION (5) HIDRAULICA TIENE UN EQUIPO DE PALANCA (30) PARA TRANSMISION DE FUERZA ENTRE LA CAJA DE DILATACION Y EL RESORTE DE CONEXION (21) DE UN INTERRUPTOR DE MOVIMIENTO POR MUELLE. EN EL EQUIPO DE PALANCA SE INTEGRA UN TOPE PARA SEGURIDAD DE SOBRECARGA PARA RESORTE DE CONEXION, QUE ES FLEXIBLE ELASTICAMENTE POR ENCIMA DE UNA FUERZA LIMITE, QUE COORDINA LA FUERZA DE ACCIONAMIENTO DEL RESORTE DE CONEXION EN EL PUNTO DE CONEXION Y ESENCIALMENTE RIGIDO POR DEBAJO DE LA FUERZA LIMITE. LA UNIDAD CONSTRUCTIVA A BASE DE TOPE Y DEL EQUIPO DE PALANCA SE CONFIGURA POR MEDIO DE UN BALANCIN DE CONEXION (31) QUE SE ENCUENTRA PRESENTE EN FORMA DE UNA PARTE DE FLEXION-CHAPA, QUE TIENE UN TRAMO DE PALANCA DE GIRO (40) EN FORMA DE L, CON EL QUE SE CONFIGURA UN RESORTE DE ESTRIBO QUE SE ABRE DE FORMA LIMITADA DE CONEXION, SUJETO PREVIAMENTE EN UNA SOLA PIEZA EN LA DIRECCION DE ABERTURA.
Patent ES-2196720-T3 (ES)
Title: Materiales de soldadura para aceros con alto contenido de cromo.
Inventor: KAWANO TAKAYUKI
IPC: C22C38/04
Filed: 1999-01-15
Granted: 2003-12-16
Abstract: ESTA INVENCION DESCRIBE MATERIALES DE SOLDAR PARA ACEROS CON ALTO CONTENIDO DE CROMO QUE PRESENTAN UNA MAYOR DUREZA Y MEJORES CARACTERISTICAS DE ARRASTRE. DE FORMA ESPECIFICA, ESTA INVENCION DESCRIBE UN MATERIAL DE SOLDAR PARA ACEROS CON ALTO CONTENIDO DE CROMO QUE CONTIENE, EN FORMA DE PORCENTAJE EN PESO ENTRE 0,03 Y 0,12% DE C, HASTA 0,3% DE SI, 0,2 A 1,5% DE MN, HASTA 0,02% DE P, HASTA 0,01% DE S, ENTRE 8 Y 13% DE CR, DE 0,5 A 3% DE MO, HASTA 0,75% DE NI, ENTRE 0,15 Y 0,3% DE V, HASTA 0,01% DE NB, ENTRE 0,05 Y 0,3% DE TA, ENTRE 0,1 Y 2,5% DE W. ENTRE 0,01 Y 0,75% DE CU, HASTA 0,03% DE AL, ENTRE 0,002 A 0,005% DE B, HASTA 0,015% DE N, Y HASTA 0,01% DE O, EL RESTO SIENDO FE E IMPUREZAS INCIDENTALES. TAMBIEN SE REFIERE A LOS MATERIALES DE SOLDAR EN LOS QUE W ES EXCLUIDO OPTATIVAMENTE DE LA COMPOSICION ANTES MENCIONADA, EN DONDE W SE EXCLUYE Y SE AÑADE 0,1 A 3% DE CO, O EN DONDE SE AÑADE ENTRE 0,1 Y 3% DE CO A LA COMPOSICION ANTERIORMENTE INDICADA.
Patent ES-2237041-T3 (ES)
Title: Cable prefabricado y procedimiento para su fabricacion.
Inventor: COPE KYLE
IPC: H01B13/14
Filed: 1999-03-31
Granted: 2005-07-16
Abstract: SE PROPORCIONA UN CABLE TRANSMISOR DE ENERGIA CON UNA CAPA DE REVESTIMIENTO LUBRICANTE SOBRE SU CUBIERTA EXTERNA, COMO UNA CAMISA EXTERNA O UN AISLAMIENTO EXTERNO DEL CABLE, QUE PERMANECE SOBRE LA CUBIERTA EXTERNA Y PROPORCIONA UN COEFICIENTE DE FRICCION ENTRE EL CABLE Y UNA SUPERFICIE DE UNION DEL CABLE INFERIOR AL COEFICIENTE DE FRICCION ENTRE EL CABLE SIN EL REVESTIMIENTO LUBRICANTE Y LA SUPERFICIE DE UNION Y QUE TIENE UNA SUPERFICIE EXTERNA QUE ESTA SECA, NO ES PEGAJOSA NI HIDROSOLUBLE. LAS CARACTERISTICAS DE LA CAPA DE REVESTIMIENTO LUBRICANTE QUEDAN BASICAMENTE INTACTAS TRAS LA EXPOSICION A LAS CONDICIONES MEDIOAMBIENTALES Y FISICAS ASOCIADAS CON EL ALMACENAMIENTO Y LA INSTALACION DE UN CABLE DE ENERGIA.
Patent ES-2232098-T3 (ES)
Inventor: OSTERMEIER PETER
IPC: B23B31/113
Filed: 1999-02-12
Granted: 2005-05-16
Abstract: The drill has an insertion area (1) at one end with a guide segment (10) and a locking element (114) which protrudes axially from the guide segment. The guide segment has at least one guide surface (101,102) and the locking element is equipped with two locking surfaces (111,112), positioned parallel to the longitudinal axis. Two recesses, one pointing towards the direction of drilling, the other one into the opposite direction, keep the drill safely locked inside the drilling machine.
Patent ES-2291016-T3 (ES)
Title: Peticion de servidor que incluye un codigo para personalizar el servicio de la estacion celular movil solicitante.
Inventor: SKOG BENGT ROBERT
IPC: H04W4/14
Filed: 1999-01-26
Granted: 2008-02-16
Abstract: Un servidor (23) que puede conectarse con una red (15) de comunicación celular dispuesto para proporcionar un servicio por medio de la red de comunicación celular a una estación móvil (21) que funciona en la red de comunicación celular, que comprende: una entrada (41) dispuesta para recibir de la estación móvil a través de la red de comunicación celular un mensaje de solicitud de un servicio proporcionado por el servidor, y una salida (49) dispuesta para proporcionar un mensaje de respuesta respondedor a dicho mensaje de solicitud del servicio, caracterizado porque dicho mensaje de solicitud para el servicio incluye un código que identifica de modo único dicha estación de servicio para determinar las capacidades operacionales de dicha estación móvil; indicando las capacidades operacionales que nivel del servicio es capaz de manipular dicha estación móvil, y porqué dicho servidor está dispuesto además para usar dicho código recibido para determinar las capacidades operacionales de dicha estación móvil, y porqué dicho mensaje de respuesta es personalizado para las capacidades operacionales determinadas de dicha estación móvil de modo que se proporciona a dicha estación móvil el nivel del servicio que está de acuerdo con las capacidades operacionales de dicha estación móvil.
Patent ES-2185322-T3 (ES)
Inventor: CHARGUERAUD VINCENT
IPC: B65D71/00
Filed: 1999-03-02
Granted: 2003-04-16
Abstract: A carton and a blank for forming a carton for holding a plurality of articles in a group. The carton comprises top (22), opposed side walls (18, 26) and a base (12, 32), hingeably interconnected together to form a tubular structure wherein at least one said side walls comprises a displaceable zone (66) arranged to protrude out of the plane of the side wall to accommodate a portion of an adjacent article. The displaceable zone comprises a multiplicity of connected sections each occupying a different plane to a next adjacent section.   <IMAGE>
Patent ES-2262316-T3 (ES)
Inventor: RAK ZBIGNIEW STANISLAW
IPC: B01D53/94
Filed: 1999-03-30
Granted: 2006-11-16
Abstract: The invention relates to a method for the catalytic reduction of dinitrogen oxide (N2O) in the presence of zeolite with the addition of a reducing agent, characterised in that the reducing agent used is a saturated hydrocarbon such as methane (CH4), propane (C3H8), LPG (C3H8/C4H10) or a combination of these reducing agents. It has been found that temperatures of 400  DEG C or lower can be achieved for complete N2O conversion even with very low concentrations of the reducing agent and in the presence of water vapour.
Patent ES-2187196-T3 (ES)
Inventor: BONCORAGLIO ANTONIO
IPC: A43B7/08
Filed: 1999-08-30
Granted: 2003-05-16
Abstract: We have invented a new sole with a pumping action for the part of the shoe near the heel, inside a cylindric pump, connected with channels near the front part of the foot connected to the outside part of the sole, with a valve for the passing of air. Therefore giving life and automatic movement of respiration and compression for the circulation of air for the inner part of the footwear, resolving all problems due to the loss of the circulation of air.
Patent ES-2258858-T3 (ES)
Inventor: DIDOMENICO JOHN D
IPC: G01N21/35
Filed: 1999-11-01
Granted: 2006-09-01
Abstract: A remote sensing device is provided to detect the emissions of passing vehicles. Preferably, the device detects the emissions of individual vehicles traveling on a roadway of more than one traffic lane. The remote sensing device may preferably detect the emissions due to an individual vehicle in situations where more than one vehicle is present. The device is capable of determining which sensed emission data corresponds to which vehicle exhaust plume.
Patent ES-2181501-T3 (ES)
Title: Composicion cosmetica.
Inventor: WEINKAUF RONNI LYNN
IPC: A61K8/00
Filed: 1999-05-05
Granted: 2003-02-16
Abstract: Una composición que consta de: (i) un alfa hidroxiácido en una cantidad de desde 0,01 hasta 20% en peso de la composición; (ii) ácido petroselínico en una cantidad de desde 0,05% hasta 20% en peso de la composición; y (iii) un vehículo cosméticamente aceptable.
Patent PL-1662158-T3 (PL)
Title: Ball joint device
Inventor: MORALES ARNAEZ AGUSTIN
IPC: F16C11/06
Filed: 2004-11-25
Abstract: A ball joint device having a ball joint (4), a ball joint seat (2) and a casing (1). The casing (1) has a casing housing (10) to house the seat (2), said casing housing (10) being configured to prevent relative movement between the casing (1) and the seat (2). The casing (1) also has a first casing end (11); a second casing end (12) opposite to the first casing end (11) having first joining elements (120) between the casing (1) and the seat (2); an intermediate portion in the casing housing (10) between the first casing end (11) and the second casing end (12), said intermediate portion having second joining elements (130) between the casing (1) and the seat (2).
Patent PL-1517051-T3 (PL)
Title: Hinge for wall fastening by chemical resin
Inventor: ARDESI PAOLO
IPC: F16B13/14
Filed: 2004-09-14
Abstract: The invention relates to a hinge (1), in particular for shutters, suitable for being fastened in a hole (3) in a wall (4) by means of a chemical fastening substance, such as a resin, comprising a stem or shank (2) designed to be inserted into said hole (3) in the wall (4), and a pin (7), which extends from the proximal end of said stem or shank (2) protruding from the wall (4). A cavity (12) extends longitudinally in said stem or shank (2), which opens from the side of the pin (7) to allow the chemical fastening substance to be injected inside, when the stem or shank (2) is inserted into the hole (3) in the wall (4) and connected externally by at least one further opening (13) in the stem or shank (2) to allow the fastening substance to come out of the cavity (12) in the hole (3). <IMAGE>
Patent PL-1680293-T3 (PL)
Title: Ventilation device for a motor vehicle window pane
Inventor: MINA LUCIANO
IPC: B60H1/24
Filed: 2004-09-29
Abstract: The device permits the ventilation of the inside of the glass pane (2) of a window (W) of a door or side (D) of a motor vehicle, wherein, immediately below the window (W), the door or side (D) is provided with an internal trim panel (1). The device comprises a substantially tubular air channel (3) which extends along the glass pane (2) in proximity to the lower edge of the window (W), and which is provided with an air outflow aperture (4) facing the glass pane (2). The aperture (4) has a lower edge (4a) coupled in a sealed manner to the glass pane (2), and an upper edge (4b) coupled to the glass pane (2) in such a way as to allow air to flow from the channel (3) towards the glass pane (2). The air channel (3) is formed integrally in the upper end portion of the internal trim panel (1) of the door (D).
Patent PL-1692472-T3 (PL)
Title: Stand for a check weigher
Inventor: BERGER HERMANN
IPC: B65G21/20
Filed: 2004-12-09
Abstract: A supporting frame for a monitoring scale is constructed, in its basic form, from a longitudinal supporting frame part ( 1 ) and at least one transverse supporting part ( 2, 2' ). Each transverse supporting part ( 2, 2' ) may include a flat, plate-shaped transverse part, via which the stand is supported on the ground. Additional supporting frame parts ( 3, 3', 3'' ), transverse supports ( 13.1 to 13.4 ), and other associated parts may also be provided for additional reinforcement.
Patent PL-1790357-T3 (PL)
Title: Perorally administrable antimicrobial composition
Inventor: KISELEV NIKOLAI ALEXANDROVICH
IPC: A61K31/545
Filed: 2005-08-25
Abstract: The invention relates to medicine and the chemical and pharmaceutical industry, in particular to antibiotic preparative forms. The inventive antimicrobial composition contains antibiotic selected from a group of lincosamides, broad-spectrum penicillins, cephalosporins, macrolides, tetracyclines, and lactulose at the active component ratio of 1:1-1:100. The mean particle size of lactulose ranges from 100 nm to 200 µm. Said composition is also embeddable in a solid state and in the form of a syrup or a suspension. When applicable, pharmaceutically acceptable excipients are added into the composition in such a way that it takes a form acceptable for peroral administration.
Patent PL-1794294-T3 (PL)
Title: Recombinant carboxypeptidase b
Inventor: VAN DEN HEUVEL JOOP
IPC: C12N15/57
Filed: 2005-09-26
Abstract: A nucleic acid coding for pro-carboxypeptidase B (Pro-CPB), comprising three segments A, B and C, wherein at least one of the segments has one of the sequences according to SEQ ID No. 1, 2 or 3.
Patent PL-1721715-T3 (PL)
Title: Chip board panel, method and apparatus of manufacturing the panel
IPC: B27N3/06
Filed: 2006-04-01
Abstract: The method involves arranging wood chips or wood fibers glued with resin in several layers (6, 7, 8) to form a splinter or fiber cake and pressing the wood chips or wood fibers together by applying pressure and temperature. At least one layer material insert (4, 5), in particular a fleece, a fabric, plastic or paper insert, is introduced between the layers before pressing and is pressed with the wood fibers or wood chips. Independent claims are also included for the following: (A) a wood material board (B) and a device for manufacturing a wood material board .
Patent PL-1881193-T3 (PL)
Title: Switching device for underwater turbine
Inventor: PENTIKÄINEN ISMO
IPC: F03B15/06
Filed: 2006-07-20
Abstract: The present invention refers to a hydromechanical device arranged to be provided in a streaming water (w) for generating power. A first inlet conduit (1) is arranged to convey a first flow of water. A second inlet conduit (2) is arranged to convey a second flow of water. A switching device (3) is provided immediately downstream the inlet conduits. A turbine (4) is provided downstream the switching device. The switching device is arranged to convey in an alternating order, the first flow and the second flow to the turbine in such a way that the first flow and the second flow alternately drives the turbine.
Patent PL-1943714-T3 (PL)
Title: Method for automatic monitoring of generator operation
Inventor: LEHMANN CHRISTOPH
IPC: G01H1/00
Filed: 2006-10-24
Abstract: The method involves detecting generator input variables (20), and calculating target-generator output variables based on the detected input variables using software by a calculating unit (14). Actual-generator output variables are detected. A comparing unit (16) compares the detected actual-generator output variables with the actual-generator output variables. An evaluation unit evaluates the comparison result. The generator input variables comprises stator voltage, stator current, supply frequency, stator winding temperature, cooling water temperature and sealing oil inlet temperature. An independent claim is also included for a system for automatically monitoring an operation of a generator.
Patent PL-1937429-T3 (PL)
Title: Method and apparatus for continuous casting
Inventor: PLOCIENNIK UWE
IPC: B22D11/124
Filed: 2006-12-28
Abstract: The cast strip is cooled in a first section (6) between the continuous casting die (3) and the mechanical deformation stage (5). The heat transfer coefficient lies between 2500 W/m 2>K and 20000 W/m 2>K. In the next section (7), temperature equalization commences within the metal strip, with or without reduced surface cooling. The result is surface heating to a temperature exceeding Ac3 or Ar3 (temperature arrest points representing transformations). Then in a third section (8), mechanical deformation (5) takes place. The heat transfer coefficient in the first section is 3000 W/m 2>K to 10000 W/m 2>K. Before cooling, the strip surfaces are cleaned. The first section is divided, for intermittent cooling. In the first subsection (6A) just after the continuous casting die, it is cooled intensively; in the following subsection (6B) cooling is reduced and then becomes more intensive. The mechanical deformation process (5), i.e. rolling or similar, causes straightening. Cooling in the first section is confined to the vertical section. The strand guidance (4) in this section is provided by metal rollers (10) with coolers (11) applying liquid to the strip surface. These can be moved vertically and/or horizontally. They can be oscillated. More fixed coolers are included. All coolers may be encased. The coolant is projected by nozzles. An independent claim IS INCLUDED FOR the corresponding continuous casting plant.
Patent PL-2015689-T3 (PL)
Title: Device for removing an external parasite
Inventor: PABARI ALPA SHANTILAL
IPC: A61B17/50
Filed: 2007-05-08
Abstract: A device 10 for removing an external parasite from a host comprises a substantially rectangular plate 11 having a projection 13 from a minor or major edge thereof The projection 13 is of a width less than half a length of the edge and comprises two prongs 134, 135 defining a first inward tapering V-shaped notch 131 between the prongs. The V-shaped notch 131 has a longitudinal axis aligned with an axis of the substantially rectangular plate 11. Opposed inner engagement faces of the prongs 134, 135 are chamfered for engaging substantially opposed sides respectively of the external parasite. One or more similar additional V-shaped notches 14, 15, smaller than the first V-shaped notch 131, may be provided on an edge opposed to the edge on which the projection 13 is located.
Patent PL-2123991-T3 (PL)
Title: Fired heat exchanger
Inventor: SIEMIEŃCZUK TOMASZ
IPC: F24H1/32
Filed: 2008-05-20
Abstract: The fired heat exchanger is characterised by the fact that it contains a modular block constituting a set of inseparably interconnected panel plates (1) with a combustion chamber located in its upper internal part (2) ensuring full integration of the combustion chamber (2) with the working heat exchange surface located in the lower part of the panel plates (1). This surface is created by the lower lateral surfaces of the panel plates (1) together with chattered lamella bands mounted on them (3). They expand the working heat exchange surface and the gasses created in the combustion chamber (2) flow around this surface. The circulation of the liquid heated medium in the unit of interconnected panel plates (1) has a medium flow velocity within the range 0.5 - 2 m/s and is of a two-stage type. During the first stage, the main process of heat exchange on the working surface takes place. During the second stage, the combustion chamber (2) is cooled by the water jacket constituting the upper part of the panel plates (1).
Patent PL-2033914-T3 (PL)
Title: Transport star wheels
Inventor: KLARL HERMANN
IPC: B65G29/00
Filed: 2006-01-13
Abstract: The wheel (1) has a replaceable fitting part exhibiting locking device and a fitting part holder exhibiting a locking device (2), where the locking device (2) is locked by rotation with the other locking device and is designed as a sleeve, a pipe piece or a shaft piece, which is rotatable around its axis. The locking device (2) is provided at an end of a radius arm (4). The locking device (2) comprises a lever, to which a pin of an actuator (18) is engaged, where the actuator includes a circular grip.
Patent PL-2148040-T3 (PL)
Title: Apron device, in particular for a building closing and/or concealing system.
Inventor: BIRKER ARNAUD
IPC: E06B9/15
Filed: 2009-07-20
Abstract: The device has a strip (2) comprising lateral ends (7, 8) and adapted to be connected to driving units (9) e.g. band. One of the lateral ends of the strip comprises clipping connection units (12) cooperated with complementary connection units (13) that are connected to the driving units. The clipping connection units are associated with an end fitting (15), and comprise tabs (16). The tabs are defined by strips (20) that are folded to define a recess .
Patent GR-3000663-T3 (GR)
Title: Trench-shoring unit
Inventor: ISCHEBECK ERNST-FRIEDRICH
IPC: E02D17/08
Filed: 1990-07-25
Abstract: The trench-supporting unit comprises opposite hollow walls with inner supporting ribs and joined together by adjustable length struts. The walls (W) are in sections of aluminium, with tongue-and-groove joints engaging together along their lengthwise edges. At their transverse edges they engage positively in recesses in lateral shoe strips (11). These have flanges protruding at the sides away from the walls, and with which the struts.
Patent GR-3002315-T3 (GR)
Title: Composition and process for lastingly reshaping the hair
Inventor: HARTMANN PETER
IPC: A61Q5/04
Filed: 1991-07-16
Abstract: Agent for permanent setting of hair based on a thioglycolic acid ester containing cysteamine or its salt, as well as a process for permanent setting of hair with said agent. The latter ensures efficient permanent setting which, at the same time, cares for the hair without curling the ends.
Patent GR-3006594-T3 (GR)
IPC: A61K31/28
Filed: 1992-12-19
Abstract: Organic platinum complexes active as anti-tumor agents in warm-blooded animals, and methods for synthesis of same, are described.