Patent SG-11201810032P-A (SG)
Title: Anti-erbb-2 antibodies and uses thereof
Inventor: Tan heng liang
IPC: C07K16/28
Filed: 2017-05-12
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111 0111010101111101011111 0 11101111101110101111011001111101111 Oil lil Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2017/196263 Al 16 November 2017 (16.11.2017) WIPO I PCT (51) International Patent Classification: C07K 16/28 (2006.01) G01N 33/68 (2006.01) Declarations under Rule 4.17: A61K 39/395 (2006.01) — of inventorship (Rule 4.17(iv)) (21) International Application Number: Published: PCT/SG2017/050253 — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (22) International Filing Date: 12 May 2017 (12.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201603812X 12 May 2016 (12.05.2016) SG (71) Applicant: AGENCY FOR SCIENCE, TECHNOLO- GY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10 Connexis North Tower, Singapore 138632 (SG). (72) Inventors: TAN, Heng Liang; c/o Bioprocessing Technol- ogy Institute, 20 Biopolis Way, #06-01, Singapore 138668 (SG). CHOO, Andre Boon Hwa; c/o Bioprocessing Tech- nology Institute, 20 Biopolis Way, #06-01, Singapore — 138668 (SG). = Agent: SPRUSON & FERGUSON (ASIA) PTE LTD; = (74) P.O. Box 1531, Robinson Road Post Office, Singapore _ 903031 (SG). Designated States (unless otherwise indicated, for every = (81) — kind of national protection available): AE, AG, AL, AM, = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, = = MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, = = = TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every (84) = kind of regional protection available): ARIPO (BW, GH, = GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, — TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, — 1-1 KM, ML, MR, NE, SN, TD, TG). M SO el (54) Title: ANTI-ERBB-2 ANTIBODIES AND USES THEREOF 0\ (57) : The present invention relates to antigen-binding proteins, or antigen-binding fragments thereof. In particular, the present 1-1 ----. invention relates to antigen-binding proteins, or antigen- binding fragments thereof that bind to ERBB2. Compositions comprising a IN , I physiologically acceptable carrier and a therapeutically effective amount of the antigen-binding protein, or antigen-binding fragment © thereof, use of the antigen-binding protein, or antigen-binding fragment thereof, methods for detecting cancer as well as kits when used N in such methods are also provided. O