baber/WOPTO huggingface dataset:
Patent CY-1118666-T1 (CY)
Title: Αναστολεις κινασης τυροσινης bruton
Inventor: HONIGBERG LEE
IPC: C07D487/04
Filed: 2017-02-22
Abstract: Στο παρόν αποκαλύπτονται ενώσεις που σχηματίζουν ομοιοπολικούς δεσμούς με κινάση τυροσίνης Bruton (Btk). Επίσης περιγράφονται μη-αναστρεπτοί αναστολείς της Btk. Αποκαλύπτονται μέθοδοι για την παρασκευή των ενώσεων. Επίσης αποκαλύπτονται φαρμακευτικές συνθέσεις που περιλαμβάνουν τις ενώσεις. Αποκαλύπτονται μέθοδοι χρήσης των αναστολέων Btk, μόνων ή σε συνδυασμό με άλλους θεραπευτικούς παράγοντες, για την θεραπεία αυτοάνοσων ασθενειών ή καταστάσεων, ετεροάνοσων ασθενειών ή καταστάσεων, καρκίνου, συμπεριλαμβανομένου λεμφώματος και φλεγμονωδών ασθενειών ή καταστάσεων.
Patent CY-1119028-T1 (CY)
Title: Φαρμακευτικη ουσια συλληψης αζωτου για χρηση σε μεθοδο αγωγης διαταραχης κατακρατησης αζωτου
Inventor: SCHARSCHMIDT BRUCE
IPC: G01N33/49
Filed: 2017-06-28
Abstract: Η παρούσα αποκάλυψη παρέχει μεθόδους για αξιολόγηση της ημερήσιας έκθεσης αμμωνίας με βάση μία και μοναδική μέτρηση επιπέδου αμμωνίας στο αίμα σε κατάσταση νηστείας, καθώς και μεθόδους που χρησιμοποιούν αυτήν την τεχνική για τη ρύθμιση της δοσολογίας μίας φαρμακευτικής ουσίας σύλληψης αζώτου, τον προσδιορισμό του εάν θα χορηγηθεί φαρμακευτική ουσία σύλληψης αζώτου, και την αγωγή διαταραχών κατακράτησης αζώτου.
Patent CY-1119816-T1 (CY)
Title: Παρακαμψη χαμηλης ισχυος για διαταξη κλειδωματος
Inventor: LEVY YAIR
IPC: G07C9/00
Filed: 2018-01-23
Abstract: Περιγράφεται μια μέθοδος για τη λειτουργία μιας διάταξης κλειδώματος, η οποία περιλαμβάνει παράκαμψη της κανονικής λειτουργίας της διάταξης κλειδώματος που τροφοδοτείται από μια μπαταρία. Εάν ένα φορτίο της μπαταρίας ελαττωθεί μέχρι ένα κατώφλιο χαμηλής φόρτισης μπαταρίας, η διάταξη κλειδώματος μεταβαίνει σε λειτουργία αδράνειας, και η διάταξη κλειδώματος μπορεί να ενεργοποιηθεί για περιορισμένο χρόνο μέσω μιας ενέργειας του χρήστη.
Patent CY-1120058-T1 (CY)
Title: Συνδυασμοι ανταγωνιστη μουσκαρινικου υποδοχεα και αγωνιστη βητα-2 αδρενεργικου υποδοχεα
Inventor: BAKER DARRELL
IPC: A61P11/08
Filed: 2018-02-06
Abstract: Παρέχονται νέοι συνδυασμοί ανταγωνιστή μουσκαρινικού υποδοχέα ακετυλχολίνης και βήτα 2 αγωνιστή για εισπνεόμενη χορήγηση μέσω της μύτης ή του στόματος και μέθοδοι χρήσης αυτών.
Patent CY-1120901-T1 (CY)
Title: Συστηματα και μεθοδοι προετοιμασιας προϊοντων τροφιμων
Inventor: GARDEN ALEXANDER JOHN
IPC: G06Q30/06
Filed: 2018-11-07
Abstract: Ένα σύστημα προετοιμασίας και παράδοσης φαγητού μπορεί να περιλαμβάνει πληθώρα μονάδων μαγειρέματος όπως φούρνους, κάθε μία περιέχουσα ένα η περισσότερα έτοιμα (προκατασκευασμένα), αλλά μερικώς ή εντελώς άψητα τρόφιμα. Τα τρόφιμα στις μονάδες μαγειρέματος προορίζονται προς παράδοση σε καθένα από ένα αντίστοιχο πλήθος προορισμών παράδοσης καταναλωτή. Οι μονάδες μαγειρέματος φορτώνονται σε ένα θάλαμο φορτίου ενός οχήματος παράδοσης για παράδοση στο πλήθος προορισμών παράδοσης προς καταναλωτές. Οι συνθήκες μαγειρέματος εντός της μονάδας μαγειρέματος ελέγχονται έτσι ώστε κάθε τρόφιμο να είναι μαγειρεμένο πριν από την άφιξη στον τόπο προορισμού του καταναλωτή. Σε τουλάχιστον μερικές από τις υλοποιήσεις, ο εκτιμώμενος χρόνος παράδοσης για κάθε τόπο προορισμού του καταναλωτή μπορεί να ανανεώνεται δυναμικά και οι συνθήκες μαγειρέματος εντός της μονάδας μαγειρέματος να ρυθμίζονται.
Patent CY-1120961-T1 (CY)
Title: Δοσολογικες μορφες απο του στοματος που περιλαμβανουν αντιαιμοπεταλιακο παραγοντα και αναστολεα οξεος
Inventor: GOLDSMITH MARK A
IPC: A61K9/20
Filed: 2018-12-05
Abstract: H παρούσα αποκάλυψη παρέχει δοσολογικές μορφές από του στόματος που εμπεριέχουν αντιαιμοπεταλιακό παράγοντα και αναστολέα οξέος, καθώς και μεθόδους αντιμετώπισης υποκειμένων με αντιαιμοπεταλιακό παράγοντα και αναστολέα οξέος.
Patent CY-1124371-T1 (CY)
Title: Ιοσωματια aav me μειωμενη ανοσοαντιδραστικοτητα και χρησεις αυτων
Inventor: ARBETMAN ALEJANDRA ELENA
IPC: C07K1/00
Filed: 2021-04-13
Abstract: Περιγράφονται μέθοδοι παρασκευής και χρήσης ιοσωματίων ανασυνδυασμένου AAV με μειωμένη ανοσοαντιδραστικότητα. Τα ιοσωμάτια ανασυνδυασμένου AAV περιλαμβάνουν μεταλλαγμένες καψιδικές πρωτείνες ή προέρχονται από ορότυπους και απομονώματα AAV μη πρωτευόντων θηλαστικών που παρουσιάζουν μειωμένη ανοσοδραστικότητα σχετικώς προς τον AAV-2.
Patent HR-P20090562-T1 (HR)
Inventor: BURNS MICHAEL PAUL
IPC: C12P41/00
Filed: 2009-10-21
Abstract: Postupak dobivanja (S)-3-cijano-5-metilheksanske kiseline, koji se sastoji u koracima: (a)	stavljanja u kontakt racemičnog 2-izobutilsukcinonitrila s enzimskim katalizatorom koji ima nitrilaznu aktivnost u reakcijskom mediju; (b)	prikupljanja (S)-3-cijano-5-metilheksanske kiseline iz reakcijskog medija; te, izborno, prikupljanja nepromijenjenog (R)-2-izobutilsukcinonitrila. Patent sadrži još 7 patentnih zahtjeva.
Patent HR-P20090690-T1 (HR)
Title: Child resistant package
Inventor: PHAM TANG B
IPC: B65D75/34
Filed: 2009-12-30
Abstract: A child resistant drug package. The package includes a blister layer having at least one blister and a plurality of backing layers covering the blister layer. The backing layers include tabs that require sequential removal in order to gain access to the contents of the blister.
Patent HR-P20120285-T1 (HR)
Inventor: NAKAMURA YUJI
IPC: A01N43/10
Filed: 2012-03-30
Abstract: Fungicidni pripravak koji kao djelatni sastojak sadrži derivat amida kiseline formule (I) ili njegovu sol: naznačen time, daA	je fenil koji se može supstituirati s X, benzodioksolanil koji se može supstituirati s X; ili benzodioksanil koji se može supstituirati s X; B	je furil koji se može supstituirati s Y, ili tienil koji se može supstituirati s Y, svaki od R1 i R2 je alkil, iliR1 i R2 zajedno mogu tvoriti zasićeni karbociklički prsten s 3 do 6 članova; X	je fluor, klor, jod, alkil, haloalkil, alkoksi ili haloalkoksi; Y	je halogen, alkil, haloalkil, alkoksi ili haloalkoksi; R'	je vodik; a svaki za sebe W1 i W2 predstavljaju kisik. Patent sadrži još 13 patentnih zahtjeva.
Patent SI-1347550-T1 (SI)
Title: Apparatus mounting duct
Inventor: KAUF PETER
IPC: H02G3/04
Filed: 2003-03-13
Abstract: The installation unit (20) has a screened casing (21) with a connection point (22). A wire (23) bonds the screened casing (21) to the earthing- and potential equalization line and connectors (16, 17) of the channel.
Patent SI-1604991-T1 (SI)
Title: Antitumor effect potentiator and antitumor agent
Inventor: UCHIDA JUNJI
IPC: A61K31/00
Filed: 2004-03-11
Abstract: The present invention provides an antitumor effect potentiator for enhancing antitumor activity of an antitumor agent comprising tegafur in a therapeutically effective amount, gimeracil in an amount effective for enhancing an antitumor effect, and oteracil potassium in an amount effective for inhibiting a side effect. The antitumor effect potentiator comprising at least one member selected from the group consisting of folinic acid and pharmacologically acceptable salts thereof. The present invention also provides a method for enhancing an antitumor effect of an antitumor agent comprising the step of administering to a patient the aforementioned antitumor effect potentiator; a method for inhibiting the growth of a tumor comprising the step of administering to a patient the aforementioned antitumor effect potentiator and a method for cancer treatment comprising the step of administering to a patient the aforementioned antitumor agent.
Patent SI-1904048-T1 (SI)
Title: Glepp-1 inhibitors in the treatment of autoimmune and/or inflammatory disorders
Inventor: BOMBRUN AGNES
IPC: A61K31/403
Filed: 2006-07-14
Abstract: The present invention is related to the use of a Glepp-1 inhibitor for the manufacture of a medicament for the treatment of an autoimmune and/or an inflammatory disorder.
Patent SI-1925896-T1 (SI)
Title: Device for feeding metal scrap into a metal melt
Inventor: PELECH STEFAN
IPC: C22B7/00
Filed: 2007-11-09
Abstract: The device for introducing metal scrap in a molten metal, comprises a heat-resistant lined cylindrical shaft (2) for injecting the metal scrap, a molten inlet (6) directed tangential to the shaft in a shaft base (3), a conducting surface outstandingly rising from inlet for the molten metal flowed in the shaft, and a concentric molten outlet (4) in the base. The shaft base forms a cone falling away from the outlet. The cone of the base forms the conducting surface and has an opening angle of 90[deg] . The inlet laterally passes to a radial outlet channel (5) subsequent to the axial outlet. The device for introducing metal scrap in a molten metal, comprises a heat-resistant lined cylindrical shaft (2) for injecting the metal scrap, a molten inlet (6) directed tangential to the shaft in a shaft base (3), a conducting surface outstandingly rising from inlet for the molten metal flowed in the shaft, and a concentric molten outlet (4) in the base. The shaft base forms a cone falling away from the outlet. The cone of the base forms the conducting surface and has an opening angle of 90[deg] . The inlet opens in the middle third level of the cone-shaped base and laterally passes to a radial outlet channel (5) subsequent to the axial outlet. A discharge aperture locked by a plug is intended on the side of the outlet opposite to the outlet channel.
Patent SI-2120616-T1 (SI)
Title: Smoking article with concentric hollow core in tobacco rod and capsule containing flavorant and aerosol forming agents in the filter system
Inventor: ZHUANG SHUZHONG
IPC: A24D1/00
Filed: 2007-12-21
Abstract: A smoking article having a cylinder of smoking material and a central tube within the cylinder of the smoking material wherein heat is convectively transferred with smoke from a lit end of the cylinder of smoking material through the central tube to a mouth end of the cylinder of smoking material in each puff. A filter system is attached to the cylinder of smoking material, and includes a plurality of segments, wherein at least one of the plurality of segments contains flavorant and aerosol forming agents encapsulated in at least one breakable capsule.
Patent SI-2226983-T1 (SI)
Title: Apparatus for transmitting and receiving a signal and method of transmitting and receiving a signal
Inventor: KO WOO SUK
IPC: H04L27/26
Filed: 2009-06-03
Abstract: The present invention relates to method of transmitting and receiving signals and a corresponding apparatus. One aspect of the present invention relates to an efficient layer 1 (L1) processing method for a transmitter and a receiver using data slices.
Patent TR-200002226-T1 (TR)
Inventor: BIHAN LO C LE
IPC: F16B21/18
Filed: 1999-11-25
Abstract: The invention concerns a fixing accessory comprising a bore (15) for passing through a particular fixing member. The invention is characterised in that to enable the use of a tool for driving through it such a fixing member, said fixing accessory (12) has, overhanging its bore (15), at least two engaging lips (23), each extending substantially transversely relative to the axis of said bore (15), and by which it is designed to be mounted releasable on the tubular nozzle usually fitted on said tool. The invention is, for example, useful for fixing a wireway base or a clamping ring on a wall.
Patent TR-200200470-T1 (TR)
Title: Fermante Süt Ürünleri ve İlgili İşlemler
Inventor: PETERMANN ROBERT
IPC: B65B3/32
Filed: 2000-07-24
Abstract: Bir dolum hacmini sinirlayan bir kap seklindeki bir paket içinde birlesik yumusak taze kesmik fermente süt ürünü olup, farkli birlesen kütleler halinde sunlari içerir: en az bir fermente süt mayasi ve en az bir tatlandirici bilesim veya en az iki fermente süt mayasi; burada maya(lar) ve tatlandirici bilesim(ler) farkli renktedirler, yan yana yerlestirilirler ve farkli maya(lar) ve tatlandirici bilesim(ler) arasindaki ara yüzey kabin hacmi içindeki bir orta yüzeydir.
Patent TR-200400121-T1 (TR)
Inventor: KAYALAR GOEKCE
IPC: A47L9/24
Filed: 2002-08-09
Abstract: The vacuum cleaner (1) according to the invention provides the grounding of the static electricity built-in elbow (3), brush (4) and the extension tube (2), to the floor being cleaned, over a contact surface (9) provided at the base of the brush (4). The grounding of the static electricity built-in elbow (3), brush (4) and the extension tube (2), to the floor being cleaned, is provided by one or more than one ring (7) and one or more than one wire (5).
Patent DE-3687636-T2 (DE)
Inventor: BELLUSSI GIUSEPPE
IPC: C10G3/00
Filed: 1986-12-16
Granted: 1993-06-24
Abstract: A crystalline, porous, synthetic material is disclosed, together with its related preparation process. Such a material of zeolitic character, containing silicon, titanium and aluminum oxides, corresponds, in its calcined and anhydrous state, to the following empirical formula: HAlO2 . q TiO2 . SiO2 wherein p has a value greater than zero and lower than or equal to 0.050, q has a value greater than zero and lower than or equal to 0.025, and the H<+> of HAlO2 can be at least partly replaceable or replaced by cations.
Patent DE-3688051-T2 (DE)
Inventor: BERMAN MICHAEL L
IPC: G01N33/569
Filed: 1986-12-08
Granted: 1993-06-24
Abstract: The present invention is concerned with an immunochemical reagent that comprises a combination of two or more of the synthetic polypeptide sequences mimicking at least one antigenic determinant of the gag-antigen, gp120 and gp41 of HTLV-III. This immunochemical reagent is particularly useful in immunoassays and for immunization.
Patent DE-3784743-T2 (DE)
Inventor: SHAW ANDREW
IPC: C07K5/06
Filed: 1987-01-16
Granted: 1993-06-24
Abstract: The invention provides a series of novel hydroxamic acids of the formula I <CHEM> which are useful as inhibitors of metalloproteases such as endopeptidases and wherein R<1> is a hydrophobic group, R<2> and R<3> are each an amino acid residue, n is 1 or 2, and A is a group of the formula:-  -CHR<4>.CO.NH<2> in which R<4> is an amino acid residue. Also described are processes for the manufacture of the hydroxamic acids, pharmaceutically acceptable salts derived from the said acids and pharmaceutical compositions containing a said acid or salt.
Patent DE-3786433-T2 (DE)
Inventor: HUGHES MICHAEL PEYTON
IPC: C08F2/00
Filed: 1987-07-30
Granted: 1993-10-28
Abstract: The catalyst residues present in an amorphous  alpha -olefin polymer are deactivated by contacting the molten polymer with sufficient water to provide at least a 3:1 water/A1 mole ratio and then the polymer is stabilized with a hindered phenolic antioxidant.
Patent TR-199800745-T2 (TR)
Inventor: MENDOLIA MICHAEL S
IPC: A61K8/60
Filed: 1996-10-10
Abstract: Elimizdeki bulus bir çözücü içinde alüminyum klorahidrat gibi teri önleyici müstahzar özellik açisindan aktif alüminyum ihtiva eden bir madde ve ayni zamanda kivamlastirma maddesi olarak da poli(etinilformamit) ihtiva eden sivi ya da kati (bar ve jel seklinde olanlar da dahil olmak üzere) bir kozmetik bilesimle ilgilidir. Söz konusu bilesim koltuk altlarinda terlemeyi azaltmak amaciyla sürülen ve içinde terlemeyi engelleme babinda alüminyum ihtiva eden maddeden yeterli miktarda ihtiva eden  bir teri önleyici müstahzar bilesim de olabilir. Bilesimi kuvvetlendirmek için amonyum asetat da bilesime eklenebilir. Bilesim bir muhafaza içinden sikilarak disari çikarilan jel formunda olabilir. Bilesim berrakligi saglamak için kirilma indisi ihtiyaci hissetmeden seffaf ve berrak olabilir.
Patent TR-199902134-T2 (TR)
Title: Sogutucu cihazlarin imalati için uygun kaliplanmis elemanlar ve bunlarin üretimi için yöntem.
Inventor: DIETRICH KARL WERNER
IPC: F25D23/06
Filed: 1998-02-19
Abstract: Sogutma cihazi sektörü için uygun, dahili ve  harici dis tabakalardan ve bunlar arasina yerlestirilmis sert poliüretan köpük göbekten olusan kaliplanmis elemanlar olup, sert köpük göbek irice açik hücreli sert poliüretan köpükten olusmakta ve dis tabakalar sert köpük göbege karsi harici hava basinciyla preslenmistirler ki burada dis tabakalar ve göbek arasinda yapistirma aksiyonunu esas alan bir bag bulunmamaktadir. Ayni zamanda bu kaliplanmis elemanlarinin üretimi için bir yöntem ve bu tarif edilen kaliplanmis elemanlar en az birini içeren sogutma cihazlari tarif edilmektedir.
Patent AT-E495908-T2 (AT)
Inventor: HEIERLI RENE
Filed: 2004-08-27
Granted: 2011-02-15
Abstract: A security object has a substrate (1) carrying a first motif (6) and mutually aligned thereto a second motif (7). The first motif (6) is formed by a volume hologram (8) and visible under a given viewing condition only. The second motif (7) can e.g. be a dye, a surface hologram, a perforation or any other non-variable or optically variable device. The first and the second motif (6, 7) combine to form a third motif, e.g. a legible text. The combination of the first motif (6) formed by a volume hologram (8) with the second motif provides an increased level of security.
Patent DE-60004231-T2 (DE)
Inventor: BORVE LARSEN
IPC: B32B27/32
Filed: 2000-06-01
Granted: 2004-04-22
Abstract: The invention describes a process for preparing a skin-bearing polypropylene foam which has utility in, for example, the manufacture of automotive parts. The process comprises coextruding a first polypropylene composition containing a blowing agent and a second polypropylene composition whereby to form a non-foamed skin of said second polypropylene composition on a foamed layer of said first polypropylene composition which foamed layer contains closed foam cells, said first composition having a melt strength of at least 1g and a strain hardening of at least 0.1g/(m.min) and said second composition having a Shore D value of 15 to 55.
Patent DE-60006558-T2 (DE)
Inventor: SHINAL C
IPC: A61K47/18
Filed: 2000-09-26
Granted: 2004-05-13
Abstract: The invention provides a therapeutic calcitriol solution which is suitable for packaging into pharmaceutical vials without producing discoloration of the antioxidant component of the solution.
Patent DE-60007007-T2 (DE)
Inventor: BOCQUET ROGER
IPC: B62D21/15
Filed: 2000-02-01
Granted: 2004-09-30
Abstract: The system comprises of a two stop pieces (16) mounted to the chassis assembly (2) of the vehicle. The stops are formed from rigid non-deformable material such as steel and are mounted directly in front of the engine (1) and rack and pinion steering assemblies (4). In the event of a frontal impact, the stops prevent deformation of the area around the engine and lessen the impact on the rack and pinion assembly.
Patent DE-60012180-T2 (DE)
Inventor: CHAUSSADE PIERRE
IPC: C03C27/12
Filed: 2000-06-23
Granted: 2005-08-18
Abstract: A bullet-proof and/or shatter-proof toughened, laminated glass plate includes a stack of glass sheets. A central ballistic system (BC) of the glass plate has, at its peripheral region corresponding to a reinforcing element (C) of the peripheral ballistic system (BP), one or more reinforcing cladding portions made from a high-strength ballistic material, and integrated in the stack. At least one of the reinforcing cladding portions is integral with the element (C) (i.e., a one-piece construction).
Patent DE-60036997-T2 (DE)
Inventor: MINATO HIRONAO
IPC: A61F13/00
Filed: 2000-11-29
Granted: 2008-08-28
Abstract: A disposable diaper is provided with a pair of side flaps 5 lying transversely outside the associated side edge 4a of an absorbent core 4, and the side flaps 5 is formed by a first side sheet 6 connected to the associated side edge portion 2 of a topsheet 2 lying in the vicinity of the associated side edge 4a of the core 4 and extending longitudinally of the diaper and a second side sheet 7 connected to the associated side edge portion 2a of the topsheet 2 and the associated side edge portion 3a of a backsheet both lying in the vicinity of the associated side edge 4a of the core 4 wherein both the first and second side sheets 6, 7 have a water pressure resistance of 100 - 1500 mm and a breathing resistance of 0.03 - 0.8 Kpa.s/m. <IMAGE>
Patent DE-60100925-T2 (DE)
Inventor: SARDONICO GENNARO
IPC: B60P1/44
Filed: 2001-06-05
Granted: 2004-08-12
Abstract: Lifting device (1) for disabled people in wheelchairs and children's pushchairs, comprising a supporting frame (2), permanently applied to a motor vehicle or a fixed installation, and a sliding foldaway platform (3) moving between a retracted position and an extracted position, with respect to said supporting frame (2). The platform (3) can also move in said extracted position, between a lowered position and a raised position, by means of an articulated parallelogram linkage system (17). The movements of the platform (3) are achieved by means of electrical actuators (9, 20). <IMAGE>
Patent DE-60105322-T2 (DE)
Inventor: PAI SRIKANTH
IPC: A61K47/02
Filed: 2001-03-16
Granted: 2005-09-15
Abstract: A low toxicity parenteral dimethyl sulfoxide free aqueous compositions containing Amphotericin B are described. The compositions essentially consist of in addition an Amphotericin B, phospholipids and sodium chloride. The compositions are sterilized by autoclaving. The process of making these compositions without the use of solvents for dissolving Amphotericin B have been described. The compositions are indicated for the treatment of invasive fungal infections.
Patent DE-60108613-T2 (DE)
Inventor: DOWD EDWARD
IPC: A61B5/288
Filed: 2001-03-20
Granted: 2006-03-23
Abstract: A fetal electrode sleeve and wire interconnect system for transmitting signals indicative of fetal heart rate from a fetus inside a mother through a cable to a monitor external to the mother. The system includes a holder having a fetal spiral electrode on one end and a maternal reference electrode on its opposite end. A safety cap has a retention groove, a grip, a tip with a recessed end opposite the grip, and a conductive sleeve. The conductive sleeve has a first end enclosed by the grip, a second end enclosed by the tip, and an intermediate exposed portion enclosed by neither the grip nor the tip. A twisted wire strand including a pair of insulated wires each having a first end and a second end, the first ends of the wires respectively connected to the fetal electrode and the maternal reference electrode, the second end of one wire attached to the first end of the conductive sleeve and the other wire being disposed inside the conductive sleeve, extending beyond the second end of the conductive sleeve, and terminating at its second end as a bare and exposed wire at the recessed end of the tip so that the second end of the wire is protected. A housing receives the safety cap and facilitates electrical connection between the wires and the cable.
Patent DE-60113809-T2 (DE)
Inventor: HEIL WOLFGANG
IPC: A61P15/12
Filed: 2001-01-18
Granted: 2006-06-22
Abstract: The present invention relates to compositions comprising drospirenone together with a pharmaceutically acceptable carrier of excipient, wherein said composition does not contain an estrogen. In one embodiment drospirenone is in micronized form. In another embodiment drospirenone is in a form having a surface area of more than 10,000 cm 2 /g. In a further embodiment drospirenone is in a form having rapid dissolution such that at least 70% of said drospirenone is dissolved within 30 minutes when the composition is subjected to dissolution testing in 900 ml of water at 37 °C using USP XXIII Paddle Method II operated at a stirring rate of 50 rpm. In a still further embodiment the composition comprises inert carrier particles containing drospirenone on their surface.
Patent DE-60114227-T2 (DE)
Inventor: CAI GUOLIN
IPC: A61P25/16
Filed: 2001-08-16
Granted: 2006-04-20
Abstract: Disclosed are compounds of the formula or pharmaceutically acceptable salts thereof wherein: represents: and A, B, G, D, E, Ra, Rb, W, and Z are defined herein. These compounds are agonists, antagonists or inverse agonists for GABAA brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAA brain receptors and are therefore useful in the diagnosis and treatment of anxiety, depression, Down Syndrome, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory. Pharmaceutical compositions, including packaged pharmaceutical compositions, are further provided. Compounds of the invention are also useful as probes for the localization of GABAA receptors in tissue samples.