baber/WOPTO huggingface dataset:
Patent EP-0979410-A1 (EP)
Inventor: MARTINEZ ALONSO CARLOS
IPC: C12N15/02
Filed: 1998-03-19
Abstract: The present invention relates to a method for determinating cytokine receptor, especially growth hormone receptor (GHR), activation, by the use of an antibody capable of discriminating between an activated and an inactive cytokine receptor conformation, especially GHR or growth hormone binding protein (GHBP) conformation, the method comprising: contacting the antibody and the cytokine receptor to form a complex, contacting a candidate ligand to the complex, measuring the antibody binding to inactive cytokine receptor and thereby discriminating between an activated and an inactive conformation. The invention also relates to an antibody directed to the hinge spanning subdomains I and II of the growth hormone receptor extracellular region and which is capable of discriminating between an activated and an inactive receptor conformation. The invention also relates to the use of the antibody for e.g. characterization of growth hormone receptor interactions and for screening for compounds stabilising die dimerization of GHR.
Patent EP-0967958-A1 (EP)
Inventor: FOERSTER THOMAS
IPC: A61K8/06
Filed: 1998-03-03
Abstract: The invention relates to lipid soluble, water insoluble cosmetic or dermatological active substances which can be included in body cleansing agents in the form of an aqueous preparation with at least 5 wt. % water soluble ionic or non-ionic surfactant content by solubilization of the active substances with a polar lipid in lipid-surfactant mixed micelles or liquid crystals or by microemulsification with a nonpolar lipid, wherein the emulsion particles have a diameter which is less than 500 nm. Said agents are also characterized by enhanced skin penetration by the active substances.
Patent EP-1009532-A1 (EP)
Title: Recuperation de composantes de coquilles d'oeufs residuelles
Inventor: MACNEIL JOSEPH H
IPC: B03B7/00
Filed: 1998-03-18
Abstract: L'invention concerne un procédé et un appareil permettant de séparer la partie membrane de coquilles d'oeufs résiduelles de leur partie minérale dure, de sorte que chacune d'entre elles puisse être utilisée ou puisse subir un traitement ultérieur tel que décrit, traitant ainsi les problèmes d'ordre économique et environnemental associés à l'élimination des coquilles d'oeufs résiduelles. On sépare la membrane de la coquille en traitant, tout d'abord, les coquilles d'oeufs résiduelles de manière à produire de petites particules de coquilles d'oeufs résiduelles. Au cours de ce traitement, les particules de coquilles d'oeufs résiduelles sont au moins légèrement écrasées, la structure de liaison entre la membrane et la coquille étant ainsi partiellement rompue. Ensuite, on dirige les particules de coquilles d'oeufs résiduelles dans un réservoir (102) contenant de préférence de l'eau, pour qu'elles s'y déposent. Lors du dépôt des particules de coquilles d'oeufs résiduelles, ces dernières sont soumises à des forces de turbulence qui séparent entièrement la partie membrane de la partie coquille.
Patent EP-0973980-A1 (EP)
Inventor: MCREE RICHARD T
IPC: E04B1/343
Filed: 1998-04-06
Abstract: L'invention porte sur une couverture rétractable pour bâtiments (20) ou espaces (22), cette couverture comprenant une pluralité de panneaux rétractables flexibles (32) auxquels sont fixés des câbles rétractables (36) stockés sur le périmètre de l'espace et pouvant être déployés sous forme d'hélice et convergeant près d'un point prédéterminé au-dessus de l'espace.
Patent EP-1003594-A1 (EP)
Inventor: ROWLEDGE DARREL
IPC: A43B5/16
Filed: 1998-04-22
Abstract: A skate includes a boot having an upper portion for supporting the lower leg, ankle and foot, and a footbed for supporting the sole of a foot. The footbed includes anterior and posterior portions as well as a hinge located between the anterior and posterior portions. The hinge permits upward pivotal movement of the anterior and posterior portions of the footbed relative to each other. The skate also includes a blade, which may include an ice skating blade or wheels. The blade has anterior and posterior portions depending rigidly from the anterior and posterior portions of the footbed respectively.
Patent EP-0991172-A1 (EP)
Inventor: SAKAKIBARA KENICHI
IPC: H02M7/155
Filed: 1998-05-20
Abstract: This single phase rectification apparatus connects a full wave rectification circuitry (3) to a single phase A.C. power source (1) through a reactor (2), connects a pair of smoothing diodes (5) which is connected in series to one another between the output terminals of the full wave rectification circuitry (3), connects a series connection circuitry of a pair of diodes (4) in parallel to the series connection circuitry (5) of the pair of the smoothing diodes, connects the center point of the pair of the diodes (4) and the center point of the pair of the smoothing diodes (5) to one another, and connects an A.C. capacitor (6) between one input terminal of the full wave rectification circuitry (3) and the center point of the pair of the smoothing diodes (5), so that decrease in size and in cost are realized for the single phase rectification apparatus in its entirety.
Patent EP-0998294-A1 (EP)
Title: Apoptose de cellules neuronales induite par un ganglioside gm3
Inventor: MILLER ROBERT H
IPC: A61K45/00
Filed: 1998-05-22
Abstract: La présente invention concerne l'aptitude du ganglioside, GM3, à inhiber la prolifération et à induire l'apoptose dans des cellules proliférantes CNS. L'invention concerne également l'aptitude de GM3 à réduire le nombre de cellules dans des cultures primaires de tumeurs gliales humaines proliférant rapidement et de la lignée cellulaire 9L du gliosarcome du rat. En outre, GM3 n'a aucun effet sur des cultures quiescentes de cellules CNS humaines. Une injection simple de GM3, trois jours après l'implantation intracrânienne de cellules tumorales dans un système murin constituant une hétérogreffe, provoque une augmentation significative de la période de survie sans symptôme chez des animaux hôtes. GM3 est, en outre, utilisé comme agent chimiothérapeutique destiné au traitement des gliomes très avancés chez l'homme.
Patent EP-0988029-A1 (EP)
Inventor: RITTER VLADIMIR
IPC: A61P17/02
Filed: 1998-06-04
Abstract: Therapeutic compositions of microspheres for application to wounds and/or lesions for accelerating wound healing and muscle regeneration. The microspheres are made up of non-biodegradable material having a substantial surface charge. The therapeutic composition further includes a pharmaceutically acceptable carrier in which the microspheres are insoluble and a container for holding the composition. The therapeutic composition further contains pharmacologic agents or biologics that accelerate the wound healing process.
Patent EP-0990041-A1 (EP)
Inventor: YAO FENG
IPC: A61K39/00
Filed: 1998-05-29
Abstract: The present invention is directed to DNA constructs suitable for gene expression in mammalian cells and which are characterized by the presence of a mammalian promoter under the control of a tet operator/repressor system. The DNA may be used as part of a system for expressing recombinant protein. In addition, the tet operator/repressor system can be used to engineer cis- and trans-destructive viruses which are capable of replicating in the presence of the tet repressor, but not in the absence of the repressor. These viruses can be used either directly in the treatment of patients with corresponding viral diseases, as vehicles for the delivery of nucleic acids that can serve as therapeutic agents and as part of vaccines designed to immunize people or animals against viral diseases.
Patent EP-0924312-A1 (EP)
Inventor: TOYOOKA TAKAAKI
IPC: C21D8/10
Filed: 1998-06-24
Abstract: A steel pipe containing fine ferrite crystal grains,
which has excellent toughness and ductility and good
ductility-strength balance as well as superior collision impact
resistance, and a method for producing the same are provided.
A steel pipe containing super-fine crystal grains can be
produced by heating a base steel pipe having ferrite grains with
an average crystal diameter of di (µm), in which C, Si, Mn and
Al are limited within proper ranges, and if necessary, Cu, Ni,
Cr and Mo, or Nb, Ti, V, B, etc. are further added, at not higher
than the Ac 3  transformation point, and applying reducing at an
average rolling temperature of m (°C) and a total reduction
ration Tred (%) within s temperature range of from 400 to Ac 3 
transformation point, with di, m and Tred being in a relation
satisfying a prescribed equation.
Patent EP-1017486-A1 (EP)
Inventor: BROOKS JULIANA H J
IPC: B01J19/12
Filed: 1998-06-17
Abstract: A wide variety of reactions can be advantageously affected and directed by a spectral catalyst which duplicates the electromagnetic energy spectral pattern of a physical catalyst and when applied to a reaction system transfers a quanta of energy in the form of electromagnetic energy to control and/or promote the reaction system. The spectral catalysts utilized in this invention can replace and/or augment the energy normally provided to the reaction system by a physical catalyst. A spectral catalyst may also act as both a positive catalyst to increase the rate of a reaction or as a negative catalyst to decrease the rate of reaction.
Patent EP-0977897-A1 (EP)
Inventor: HOEHFELD MARKUS
IPC: B21B1/46
Filed: 1998-04-09
Abstract: The invention relates to a method for cooling metals in a steel works. According to the method, the cooling is adjusted in accordance with the temperature of the metal in order to bring the metal to a desired temperature. The temperature of the metal is determined or estimated in advance, by means of a temperature model. The parameters of said temperature model, especially the heat transmission coefficients and the heat conductivity of the metal are adjusted by means of genetic algorithms to take into account the properties of the metal and the cooling, with the aim of optimization.
Patent EP-1015892-A1 (EP)
Title: Double injecteur pour systeme d'immunoanalyse par chimioluminescence
Inventor: DIAMOND RONALD N
IPC: G01N35/10
Filed: 1998-06-25
Abstract: Un double injecteur (28) destiné à un instrument d'imuno-essai automatisé permet d'effectuer la détection séquentielle de deux marqueurs de chimioluminescence différents dans un instrument. L'injecteur comporte quatre orifices (76, 78, 80, 82) soigneusement conçus. Les orifices sont prévus pour travailler par paires. Les orifices 1 (76) et 2 (78) peuvent être utilisés pour injecter des réactifs déclencheurs A et B tels que de l'acrédium, qui peuvent déclencher une réaction chimioluminescente. Les orifices 3 (80) et 4 (82) peuvent injecter des réactifs déclencheurs C et D tels que du luminol pour déclencher une réaction chimioluminescente. On peut utiliser les deux paires de manière séquentielle pour générer des signaux dans les puits d'une cuvette. Il est par conséquent possible de mener à la fois des dosages à base d'acridium et à base de luminol dans un seul instrument. L'injecteur est conçu pour se placer dans les puits de la cuvette et pour injecter les réactifs déclencheurs d'une manière qui remet efficacement en suspension les particules magnétiques d'un diamètre compris entre 1 et 8 microns. La conception de ce double injecteur permet également d'éviter la contamination ou l'entraînement des solutions de déclenchement d'un orifice à l'autre.
Patent EP-1012331-A1 (EP)
Inventor: TENG CHING-LEOU
IPC: A61K48/00
Filed: 1998-07-01
Abstract: The present invention relates to compositions and methods which enhance the local and systemic uptake and delivery of oligonucleotides and nucleic acids via non-parenteral routes of administration. Pharmaceutical compositions comprising oligonucleotides disclosed herein include, for systemic delivery, emulsion and microemulsion formulations for a variety of applications and oral dosage formulations. It has also surprisingly been discovered that oligonucleotides may be locally delivered to colonic sites by rectal enemas and suppositories in simple solutions, e.g., neat or in saline. Such pharmaceutical compositions of oligonucleotides may further include one or more penetration enhancers for the transport of oligonucleotides and other nucleic acids across mucosal membranes. The compositions and methods of the invention are utilized to effect the oral, buccal, rectal or vaginal administration of an antisense oligonucleotide to an animal in order to modulate the expression of a gene in the animal for investigative, therapeutic, palliative or prophylactic purposes.
Patent EP-1007844-A1 (EP)
Title: Generatrice pour eolienne a vitesse variable
Inventor: MIKHAIL AMIR S
IPC: F03D9/00
Filed: 1998-08-07
Abstract: L'invention concerne un système à vitesse variable destiné à des systèmes tels que des éoliennes. Le système comprend une génératrice à rotor bobiné (620), un régulateur de couple (623) et un régulateur de pas (PID) proportionnel, intégral et dérivé (1010). Le régulateur de couple régule le couple de la génératrice au moyen de commandes orientées champ, le PID assurant la régulation du pas sur la base de la vitesse du rotor de la génératrice.
Patent EP-1015453-A1 (EP)
Inventor: DININNO FRANK P
IPC: C07D487/08
Filed: 1998-09-04
Abstract: L'invention concerne des agents antibactériens du type carbapenem, dans lesquels le noyau carbapenem est substitué en position 2 avec un phényle iodo substitué, lié par un groupe CH2-O. Les composés de l'invention sont représentés par la formule (I). L'invention porte aussi sur les sels et les hydrates desdits agents. De plus, le cycle phényle iodo est substitué par différents groupes de substituants dont au moins un groupe cationique. Des compositions pharmaceutiques et des procédés de traitement sont également décrits.
Patent EP-1047647-A1 (EP)
Inventor: VIDTS DIRK
IPC: C04B16/06
Filed: 1998-10-08
Abstract: L'invention concerne des fibres de polypropylène pour le renforcement de produits en fibres-ciment ainsi que le procédé de traitement de ces fibres et les produits en fibres-ciment renforcés par de telles fibres. Les fibres suivant l'invention comportent, en surface, un dépôt de polymères organiques comportant des monomères oléfiniques et comportant des groupes polaires; ce dépôt étant obtenu par traitement de surface à l'aide d'une dispersion aqueuse desdits polymères. Les produits en fibres-ciment suivant l'invention présentent des caractéristiques de travail de rupture améliorées ainsi qu'une meilleure résistance à la fissuration.
Patent EP-1043283-A1 (EP)
Inventor: OISHI KAZUMASA
IPC: C03C25/10
Filed: 1998-10-20
Abstract: An optical fiber coating method comprising the steps
of applying an injected first resin (11) to a periphery of
an optical fiber (1) while inserting the optical fiber (1)
into a first die hole(3a) provided in a first coating die
(3), and further applying an injected second coating resin
(15) to a periphery of the first coating resin (11) while
inserting the optical fiber (1) into a second die hole (4a)
provided in a second coating die (4), wherein the first and
second die holes (3a, 4a) are arranged coaxially, the second
coating resin (15) is injected into the second die hole (4a)
through the clearance (10) formed between the first and second
coating dies (3, 4), the first coating die (3) has a protrusion
(5) around the outlet of the first die hole (3a) projecting
in the passing direction of the optical fiber (1) so as to
regulate a flow of the second coating resin (15) into the
line with the passing direction of the optical fiber (1).
Patent EP-1025638-A1 (EP)
Inventor: NEFFLING TONI
IPC: H03F1/32
Filed: 1998-10-26
Abstract: The invention relates to a linearization method and an amplifier arrangement, in which a signal to be amplified is predistorted by utlilizing digital predistortion information stored in the memory of a predistortion controller. Predistortion means predistort the signal to be amplified in its analogue form, the predistortion is adapted at least to the signal to be amplified, the predistorion information stored in the memory of the controller correspond to the variables of polar coordinates, such as phase and amplitude, and the phase and amplitude of the signal to be amplified are distorted in the predistortion in accordance with the predistortion information located in the memory of the controller.
Patent EP-1131143-A1 (EP)
Inventor: PARTON DENIS
IPC: A63F9/10
Filed: 1998-10-30
Abstract: Selon cette invention, un support de puzzle comprend une base sur laquelle reposent des couvercles, lesdits couvercles étant assujettis à la base de façon amovible. Les couvercles sont placés sur la partie supérieure de la base et retenus par du Velcro® ou au moyen de fixations souples ou à ressorts.
Patent EP-1123250-A1 (EP)
Inventor: MANNING THOMAS W JR
IPC: B65H54/26
Filed: 1998-10-20
Abstract: Cette invention concerne un appareil enrouleur qui permet d'enrouler du spandex par les trajets indépendants de lignes de fils dans le cas d'enrouleurs empilés, ainsi qu'un procédé d'utilisation de cet appareil. Cet appareil comprend un système permettant de diriger indépendamment un premier ensemble de lignes de fils de spandex (4A) vers un enrouleur supérieur (3A), ainsi qu'un second ensemble de lignes de fils de spandex (4B) vers un enrouleur inférieur (3B), le premier et le second ensembles de lignes de fils étant disposés par alternance. Chaque faisceau de tubes (1A) monté sur l'enrouleur supérieur est déplacé axialement depuis un faisceau de tubes (1B) correspondant monté sur l'enrouleur inférieur, ceci selon une distance représentant environ la moitié de la longueur du faisceau de tubes.
Patent EP-1032662-A1 (EP)
Inventor: GORCZYNSKI REGINALD M
IPC: C12N15/09
Filed: 1998-11-06
Abstract: Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of a CD200 protein or a nucleic acid encoding a CD200 protein. The methods are useful in preventing graft rejection, fetal loss, autoimmune disease, and allergies. Methods and compositions for preventing immune suppression are also disclosed. The methods involve administering an effective amount of an agent that inhibits CD200. Such methods are useful in treating cancer.
Patent EP-1037856-A1 (EP)
Title: Procede et dispositif de production d'eau pure
Inventor: TERAEVAE JORMA
IPC: C02F9/00
Filed: 1998-11-11
Abstract: La présente invention concerne un procédé et un dispositif de production d'eau d'un niveau élevé de pureté. En l'occurrence, on entretient une circulation d'eau via des unités de filtres tangentiels, en maintenant de façon continue le circuit à une température supérieure à 100 °C. De cette façon, la stérilisation est effective, et si on utilise des filtres appropriés, l'eau produite est de qualité injectable. En sortie des unités de filtres, l'eau produite est amenée dans des échangeurs thermiques, ce qui permet le préchauffage du circuit de filtration. L'absence de vaporisation de l'eau pendant le traitement permet des économies d'énergie.
Patent EP-1035408-A1 (EP)
Inventor: TSUTSUI KAZUNORI
IPC: G01N21/47
Filed: 1998-11-19
Abstract: An apparatus for measuring the intensity of scattered light from a
sample in terms of a function of a scattering angle, comprising an
ellipsoidal mirror (24) for reflecting scattered light from a sample
(23) and concentrating the same, an imaging lens (25) disposed at a
concentration point of the reflected light from the ellipsoidal mirror
(24) and forming an image of the image formed on the surface of the
ellipsoidal mirror (24), and a camera (26) for recording the image
formed by the imaging lens (25), whereby the detection of scattered light
in a range of a wide angle in a very short period of time.
Patent EP-1048246-A1 (EP)
Inventor: MAEDA MINORU
IPC: B60N2/58
Filed: 1998-11-25
Abstract: A seat having a seat surface of a planar elastic body,
comprising a seat frame (1) of a substantially quadrilateral
frame body, a planar elastic body (2) forming a seat surface
portion, a pad member (3) forming a greatly bulging bank
portion, and a facing member (4) covering the pad member (3),
the planar elastic body (2) being spread within the seat
frame (1) with one end portion of the facing member (4)
applied and fixed to an outer surface of the frame body of
the seat frame (1), the pad member (3) being fixed on an
outer surface of the seat frame (1) while covering the
mentioned end portion of the facing member (4) therewith, the
facing member (4) being put on an outer surface of the pad
member (3) from the mentioned end portion thereof applied and
fixed to the frame body of the seat frame (1), the other end
portion of the facing member (4) being wound onto and fixed
to a rear portion of the seat frame (1) to thereby form the
bank portion which bulges higher than the seat surface
portion formed of the planar elastic body (2) spread within
the seat frame (1), and which is assembled to a simple and
strong structure, the pad member (3) preventing the seat
frame (1) from contacting a person sitting on the seat,
whereby the seat does not give him a feeling of physical
disorder.
Patent EP-0956062-A1 (EP)
Inventor: VILLETTE ALAIN
IPC: A61M5/32
Filed: 1998-11-27
Abstract: Injecteur à usage médical notamment de produits pâteux, comprenant dans une enveloppe (1) au moins un moteur électrique (3) d'injection poussant un piston (6) agissant sur le fond mobile (4) d'une carpule (5), le moteur (2) étant mobile en translation à l'intérieur du corps (1) pour exercer les efforts dans l'axe.
Patent EP-1032819-A1 (EP)
Title: Procede de differentiation des erythroblastes
Inventor: LI YI
IPC: G01N33/49
Filed: 1998-11-13
Abstract: La présente invention concerne un procédé permettant de différencier des réticulocytes. L'invention concerne, en outre, une différentiation concurrente de sous-populations de leucocytes, dans un échantillon de cellule sanguine, à l'aide de mesures optiques et électroniques appropriées. Le procédé consiste à exposer un échantillon de cellule sanguine à un système réactif, de façon à lyser des globules rouges mûrs, puis à analyser les réticulocytes par analyse optique, dans une cellule d'écoulement. On peut effectuer une différentiation concurrente de réticulocytes et de leucocytes à l'aide d'analyses optique et électronique. Ces analyses optique et électronique consistent à mesurer la dispersion de la lumière et l'impédance. Ce procédé ne requiert pas l'utilisation d'une souche nucléaire pour différencier les réticulocytes.
Patent EP-0996287-A1 (EP)
Inventor: HAMADA ICHIRO
IPC: H04N21/4363
Filed: 1998-12-15
Abstract: A switching portion of an IRD supplies a non-descrambled
TS (transport stream) received from a front
end portion or a descrambled TS received from a
descrambler to a DVCR connected to an IEEE 1394
interface. In addition, data received from the DVCR is
supplied to the descrambler.
Patent EP-0971077-A1 (EP)
Inventor: MIYACHI ISAO
IPC: E02F9/00
Filed: 1998-12-25
Abstract: A guard cover for a construction machine is disclosed which comprises a
first guard cover (12), the first guard cover covering devices to be inspected
from both front and upper surface sides of the devices, the first guard cover
capable of being opened and closed vertically, and a second guard cover (13)
which becomes contiguous to the first guard cover (12) when closed and
which covers devices to be subjected to servicing from a side of the devices,
the second guard cover capable of being opened and closed in the transverse
direction. According to this construction, the first and second guard covers
can be opened each independently, so the devices to be subjected to
inspection can be inspected by an operator within an opened range of the
first guard cover (12) and the devices to be subjected to servicing can be
serviced by a serviceman within an opened range of the second guard cover
(13). Thus, the object of inspection by the operator and the object of
servicing by a serviceman are clearly distinguished from each other,
resulting in that both inspecting work and servicing work are greatly
improved in their efficiency.