Patent SG-11201407678Y-A (SG)
Title: Somatostatin receptor agonist formulations
Inventor: NISTOR CATALIN
IPC: A61K9/127
Filed: 2013-05-24
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 28 November 2013 (28.11.2013) WIPOIPCT (10) International Publication Number WO 2013/174978 A1 (51) International Patent Classification: A61K9/00 (2006.01) A61K 47/10 (2006.01) A61K 9/127 (2006.01) A61K 47/14 (2006.01) A61K38/00 (2006.01) A61K 47/24 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/EP2013/060739 24 May 2013 (24.05.2013) English (30) Priority Data: PCT/EP2012/059917 25 May 2012 (25.05.2012) 61/730,613 28 November 2012 (28.11.2012) English EP US (71) Applicant: CAMURUS AB [SE/SE]; Ideon, Gamma 1, Solvegatan 41, SE-223 70 Lund (SE). (72) Inventors: NISTOR, Catalin; Camurus AB, Ideon, Gamma 1, Solvegatan 41, SE-223 70 Lund (SE). JOHNS- SON, Markus; Camurus AB, Ideon, Gamma 1, Solvegatan 41, SE-223 70 Lund (SE). TIBERG, Fredrik; Camurus AB, Ideon, Gamma 1, Solvegatan 41, SE-223 70 Lund (SE). (74) Agent: DEHNS; St Bride's House, 10 Salisbury Square, London EC4Y 8JD (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) 00 l> o\ •t l> i-H cn i-H o CJ o & (54) Title: SOMATOSTATIN RECEPTOR AGONIST FORMULATIONS (57) Abstract: The present invention relates to compositions forming a low viscosity mixture of: a) 20-50 wt.% of at least one diacyl glycerol; b) 20-54 wt.% of at least one phosphatidyl choline (PC); c) 5-15wt.% of at least one biocompatible, organic mono-alcohol - ic solvent; d) 1 to 20 wt.% polar solvent e) 5 to 150 mg/ml of at least one peptide somatostatin receptor agonist comprising pasireotide; f) optionally at least one antioxidant; wherein the ratio of components a:b is in the range 40:60 to 54:46; wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with excess aqueous flu­ id. The invention further relates to methods of treatment comprising administration of such compositions, and to pre-filled adminis - tration devices and kits containing the formulations.