baber/WOPTO huggingface dataset:
Patent AT-E233342-T1 (AT)
Inventor: BERGER JOSEF
IPC: D21B1/32
Filed: 1998-08-21
Granted: 2003-03-15
Abstract: The disclosure relates to a process for the treatment of old paper without the use of biocides and chlorine compounds as well as with the virtual avoidance of hydrogen peroxide and/or peracetic acid with a total germ count of less than 1000 CFU/g and/or a surface germ count of less than 20 CFU/dm2, comprising the following process steps: a treatment of the pre-sorted, optionally pre-shredded, old-paper starting material in an environment containing water in order to activate the microorganism spores, a germination of the spores, a further processing of the old-paper starting material containing germinated spores, preferably in at least one separation stage in a generally known manner at temperatures above room temperature (20° C. to 70° C. [68° F. to 158° F.]), optionally comprising pre-sorting, flotation, fine-sorting, washing and deckering, while returning the separated and de-pulped clear water, all the way to the dissolving stage, followed by hot dispersion of the further processed paper starting material in a water vapor atmosphere at atmospheric overpressure, temperature-controlled treatment and processing in a generally known manner into a largely spore-free recycled pulp, from that into a largely spore-free recycled base tissue and from that into a tissue product suited for final consumption; it also relates to the recycled base tissue or tissue product thus obtained and to a device for the execution of the process.
Patent AT-E280797-T1 (AT)
Inventor: SASAKI HIDEHIRO
IPC: C08J9/16
Filed: 1998-12-01
Granted: 2004-11-15
Abstract: The present invention relates to expanded polypropylene resin beads which comprise, as a base resin, a random copolymer obtained by copolymerizing propylene and one, or two or more in admixture of comonomers selected from ethylene and  alpha -olefins having four or more carbon atoms by use of a metallocene polymerization catalyst, wherein said base resin is mainly composed of an isotactic polypropylene resin having a melting point exceeding 140 DEG C and a melt flow rate of 12 g/10 minutes or below. As the base resin, there is preferably used, for example, a random copolymer of propylene and ethylene. In the invention, the expanded beads are filled in a mold, and heating the expanded beads with steam to cause expansion of the beads until the beads are mutually fused together thereby producing a molded article having a shape of the mold. <IMAGE>
Patent AT-E294283-T1 (AT)
Inventor: YONEDA SATORU
IPC: E01H5/04
Filed: 1999-12-01
Granted: 2005-05-15
Abstract: Onto an auger housing (8) is mounted a battery stand (60) also serving as reinforcement for the stand (60). The stand (60) is provided with snow dropping bores (60e and 60f). A battery (72) is loaded on the stand (60) and covered with a cover (80) having slopes (80a and 80b) used for dropping snow therealong.
Patent AT-E329624-T1 (AT)
Inventor: DEAN RICHARD T
IPC: A61K51/00
Filed: 1993-05-21
Granted: 2006-07-15
Abstract: This invention relates to radiolabeled reagents that are scintigraphic imaging agents for imaging sites of thrombus formation in vivo, and methods for producing such reagents. Specifically, the invention relates to reagents each comprised of a specific binding compound, capable of binding to at least one component of a thrombus, covalently linked to a radiolabel-binding moiety. The invention provides these reagents, methods and kits for making such reagents, and methods for using such reagents labeled with technetium-99m to image thrombus sites in a mammalian body.
Patent AT-E246688-T1 (AT)
Inventor: SEBASTIAN ALICE
IPC: C07D307/77
Filed: 1999-02-24
Granted: 2003-08-15
Abstract: A novel process for the preparation of codeinone and analogues thereof comprising the oxidation of a compound of formula, <CHEM>     or a salt thereof, wherein R<1> is lower alkyl or a group <CHEM> wherein R<4> is lower alkyl, lower alkyl substituted by halogen or phenyl, phenyl or substituted phenyl; and R<2> is lower alkyl, allyl or lower alkyl substituted by cycloalkyl, characterised in that the oxidation is carried out in an acidic environment is disclosed.
Patent AT-E301322-T1 (AT)
Inventor: HERREROS RODRIGUEZ CARLOS JAVI
IPC: A61F5/37
Filed: 1999-12-22
Granted: 2005-08-15
Abstract: CODED MEANS AND SYSTEM FOR NEONATAL CARE, which consist of a mother record which contains all the physical elements for implementing the system which appears in illustrated and textual form on the back of the said mother record; in the obverse there is a record for the signature of the attending health official, a self-copying record with a fixed part and other separable parts and, essentially, a self-adhesive label, cleverly stamped out or perforated in order to be divided in sequence for different supports, these parts being coded with the same visible code and with invisible microcodes which are independent or shared and intended to be attached to the mother record itself, to the record file, to the mother's bracelet, to the child's bracelet and to the cord clamp. <IMAGE>
Patent AT-E243375-T1 (AT)
Inventor: LEHMANN PIERRE
IPC: H01R13/187
Filed: 1999-11-30
Granted: 2003-07-15
Abstract: The female contact piece (1) has a holder with a contact clip insert (4) for a male pin section. The contact clip has an annular crown (40) fixed in the holder with a number of flexible tongue sections (41) having a free end (410) towards the holder opening.
Patent AT-E350885-T1 (AT)
Inventor: LOGOTHETIS JAMES J
IPC: H01L23/14
Filed: 1999-02-11
Granted: 2007-01-15
Abstract: A platform is provided for the manufacture of microwave, multilayer integrated circuits and microwave, multifunction modules. The manufacturing process involves bonding fluoropolymer composite substrates into a multilayer structure using fusion bonding. The bonded multilayers, with embedded semiconductor devices, etched resistors and circuit patterns, and plated via holes form a self-contained surface mount module. Film bonding, or fusion bonding if possible, may be used to cover embedded semiconductor devices, including embedded active semiconductor devices, with one or more layers.
Patent AT-E300307-T1 (AT)
Inventor: FINIDORI CLAUDINE
IPC: A61K8/21
Filed: 1999-04-20
Granted: 2005-08-15
Abstract: The invention concerns the use of at least one pharmaceutically acceptable fluoride ion vector for preparing a medicine for prevention or adjuvant therapy treatment of a disease associated with Helicobacter pylori.
Patent AT-E249020-T1 (AT)
Inventor: HENRY CHRISTOPHE
IPC: C01B32/55
Filed: 1999-06-18
Granted: 2003-09-15
Abstract: The refrigerating block (1) is characterized in that it consists of a container (2) made of permeable material that can resist low temperatures under zero degrees Celsius and in that said refrigerating block (1) has a refrigerating content (3) consisting of a snow mass which is enclosed and retained by said container (2).
Patent AT-E309087-T1 (AT)
Inventor: DENNY BARRY
IPC: B31D1/02
Filed: 1999-09-06
Granted: 2005-11-15
Abstract: Adhesive labels are manufactured by cutting windows in an upper layer of a support web (2) through to a lower silicon coated material. Folded leaflets (15) are then adhered by lines of adhesive (11, 12, 13) to the support web (2) and the combination is die-cut to form individual adhesive labels with part of the die-cut folded leaflet extending beyond an edge of a base label formed from the window in the support web. This method of manufacture permits more complex label structures to be constructed without pre-cutting individual base labels.
Patent AT-E284949-T1 (AT)
Inventor: BIJL DIRK JOHANNES
IPC: C11D3/00
Filed: 1999-09-08
Granted: 2005-01-15
Abstract: There is provided a structured liquid detergent composition with (i) less than 10 % volume phase separation after 21 days at 25  DEG C from the time of preparation; (ii) a viscosity lower than 500 mPa.s at a shear rate of 21 s-1; and (iii) a Dissolution Time - as measured herein - of less than 120 seconds while being stable without deflocculating polymer. In addition a process is provided to clean laundry using said composition.
Patent AT-E255651-T1 (AT)
Inventor: BLACKMORE PHILLIP W
IPC: B32B5/26
Filed: 1999-12-22
Granted: 2003-12-15
Abstract: A lightweight, high-strength composite fabric suitable for use in carpet backing, roofing and membranes and other products which employ rugged fabrics. The composite fabric comprises a layer of nonwoven material disposed between a layer of low shrinkage warp strands and a layer of low shrinkage weft strands. The layers are stitched or knitted together and the resultant fabric may be coated with a resin or sizing to prevent slippage between the several layers of the fabric and impart a measure of stiffness to the fabric. The fabric may be manufactured in sheet or, more preferably, roll form and may be coated with materials suitable for desired end applications, e.g., bituminous material whereby the fabric may function as a ready-to-use roofing membrane or other high-strength fabric product.
Patent AT-E333502-T1 (AT)
Inventor: BRADBURY ANDREW RAYMON MORTON
IPC: C12N9/00
Filed: 1999-11-18
Granted: 2006-08-15
Abstract: This invention provides novel methods of generating large, highly diverse, nucleic acid (and hence polypeptide) libraries. The methods exploit the discovery that recombination, particularly recombinase recombination can occur between two or more constructs of the same type (e.g. having the same origin of replication and/or the same regulatory or selectable markers). The methods thus involve introducing at least two members of an initial population of nucleic acid molecules into at least one cell under conditions were recombination (e.g recombinase mediated recombination) can occur between the nucleic acids. The nucleic acid molecules preferably comprise two or more individual nucleic acids each of which consists of a nucleic acid sequence that is identical for each molecule and that includes an origin of replication; and a nucleic acid sequence that varies between members of said population. Thus, a single type of construct is capable of mediates all of the recombination events providing substantially greater efficiency and the creation of substantially larger and more diverse nucleic acid libraries.
Patent DE-05785170-T1 (DE)
Inventor: MARCUSSEN ERIK SCHMIDT
IPC: A23K1/165
Filed: 2005-09-27
Abstract: The present application relates to a steam treated pelletized feed composition comprising a granule comprising a core and a coating wherein the core comprises an active compound and the coating comprises a salt.
Patent DE-10842945-T1 (DE)
Title: Drahtlos angetriebener erschöpfungssensor zur strukturenzustandsüberwachung
Inventor: DOLEN MELIK
IPC: G01N3/00
Filed: 2010-01-16
Abstract: Gerät zur Überwachung des Gesundheitszustands eines Strukturelements einer Struktur, umfassend: eine Mehrzahl von zerbrechlichen Trägern, und Elektronik zur Erfassung des Vorhandenseins zerbrochener Träger, und einen Prozessor und zugehörige Teile zum drahtlosen Aussenden einer Information betreffend die Existenz von zerbrochenen Trägern, und eine Energiequelle, um den Sensor mit Energie zu versorgen, wobei das Gerät, welches von nun auch als „Sensor” bezeichnet wird, an dem oder nahe dem Strukturelement angebracht ist, welches einer wiederholten zyklischen Biegebewegung ausgesetzt ist, derart, dass es der gleichen wiederholten zyklischen Biegebewegung wie das Strukturelement ausgesetzt ist, dessen Gesundheitszustand überwacht werden soll.
Patent ES-2246195-T1 (ES)
Inventor: POWELL COLIN
IPC: B22C9/08
Filed: 2004-10-21
Abstract: A feeder element includes a first end (16) for mounting on a mold pattern (24), an opposite second end for receiving a feeder sleeve, and a bore between the first and second ends defined by a sidewall (12a-b). An independent claim is also included for a feeder system for metal casting comprising a feeder element and a feeder sleeve (20).
Patent ES-2395093-T1 (ES)
Title: Proceso para producir un extracto de alérgenos
Inventor: CARNES SANCHEZ JERONIMO
IPC: A61K39/35
Filed: 2011-02-11
Abstract: Un proceso para producir un extracto de alérgenos que comprende:a) poner en contacto un material de origen natural con un agente de extracción líquida para producir unamezcla que contiene lípidos disueltos en la fase líquida, y una fase sólida que consiste en residuos del material deorigen que comprenden alérgenos y proteínas, entre otras muestras biológicasb) someter la mezcla a una primera etapa de separación para aislar los residuos del material de origen;c) poner en contacto los residuos del material de origen con un agente de extracto de alérgenos para produciruna mezcla de alérgenoalérgenos/proteinas disuelta en la fase líquida, y una fase sólida que consiste en residuos noalergénicos,d) someter la mezcla a una segunda etapa de separación para aislar los alérgenos disueltos en la fase líquida,para producir un extracto de alérgenos bruto,e) someter al extracto de alérgenos bruto a una etapa de eliminación de fracciones de bajo peso molecularpara eliminar las moléculas que tengan un tamaño molecular menor que 3,5 kDa, yf) llevar a cabo la etapa e) hasta que el extracto de alérgenos tenga una conductividad menor que 1000 μS/cma 3-5ºC para obtener un extracto de alérgenos nativos purificado.
Patent ES-2100140-T1 (ES)
Title: Metodo de producir separaciones litograficas multidimensionales libres de interferencia muare.
Inventor: GOGGINS TIMOTHY P
IPC: G03F5/22
Filed: 1995-04-28
Abstract: LITOGRAFIAS MULTIDIMENSIONALES QUE IMPARTEN LA ILUSION DE PROFUNDIDAD Y/O MOVIMIENTO A UN OBSERVADOR. ESTAS LITOGRAFIAS SE PREPARAN POR MEDIO DE LA CONSTRUCCION Y SECUENCIACION DE UNA PLURALIDAD DE PAGINAS ELECTRONICAS, PREFERIBLEMENTE CUATRO O MAS; CUADRICULACION, COMPRESION Y CONVERSION DE CADA PAGINA; ENTRELAZADO DE LAS PAGINAS EN UNA SECUENCIA DESEADA; SACADO DE LOS ARMAZONES ENTRELAZADOS EN UN DISPOSITIVO DE PRODUCCION DE IMAGENES; Y PRODUCCION DE UNA SEPARACION LITOGRAFICA A PARTIR DEL DISPOSITIVO DE PRODUCCION DE IMAGENES. EN EL CUADRICULADO DE CADA ARMAZON, SE CREAN UNOS PIXELES NO BINARIOS QUE SE CORRESPONDEN CON LA RESOLUCION DEL CALCULO DE LINEAS DE LA LENTE LENTICULAR QUE SERA AL FINAL APLICADA A UNA IMPRESION DE LA LITOGRAFIA EN UN NUMERO DE VECES TAL COMO ARMAZONES HAY EN LA SEPARACION LITOGRAFICA. LOS ARMAZONES SON COMPRIMIDOS EN UNA CANTIDAD IGUAL QUE LA CANTIDAD RECIPROCA DEL NUMERO DE ARMAZONES DESDE LOS QUE SE PREPARA LA SEPARACION LITOGRAFICA. EN EL PASO DE CONVERSION,LOS PIXELES NO BINARIOS DE LOS ARMAZONES COMPRIMIDOS SE CONVIERTEN EN PLACAS DE COLOR INDIVIDUALES DE PIXELES BINARIOS. LAS SEPARACIONES LITOGRAFICAS MULTIDIMENSIONALES NO TIENEN INTERFERENCIAS DE MUARE NI DE LA PANTALLA.
Patent ES-2100147-T1 (ES)
Inventor: VUILLAUME ANDRE
IPC: D04H18/04
Filed: 1996-02-13
Abstract: PCT No. PCT/FR96/00227 Sec. 371 Date Mar. 5, 1997 Sec. 102(e) Date Mar. 5, 1997 PCT Filed Feb. 13, 1996 PCT Pub. No. WO96/27040 PCT Pub. Date Sep. 6, 1996Apparatus for the production of a nonwoven material wherein a web of material is drawn over a series of parallelly aligned porous rolls. The web is treated with a jet of pressurized water as it moves in contact over each roll. The web is compressed between the first roll in the series and is wetted by a curtain of water as it is being compressed to increase the density of the web material prior to its being treated with the pressurized jets of water.
Patent CY-1108553-T1 (CY)
Inventor: ALBINSON FREDERICK DAVID
IPC: C07J17/00
Filed: 2008-09-03
Abstract: The present invention relates to a process for the preparation of a compound of formula (I) which comprises the following step: wherein step (a) comprises oxidation of a solution containing the compound of formula (II) wherein the solution is formed in a mixture of water and tetrahydrofuran.
Patent CY-1109735-T1 (CY)
Inventor: REINECKE JULIO
IPC: A61K35/14
Filed: 2010-01-15
Abstract: Preparing a conditioned blood composition from blood, comprises withdrawing blood from a human or animal body; incubating the blood in a modified container with internal surface at 10-40[deg]C for conditioning of the blood, where the factors are induced, and the modified container exhibits an internal surface of at least 100 mm 2> per 1 ml of incubating blood (surface index); and obtaining a conditioned blood composition with induced factors in the modified container. An independent claim is included for a blood composition, obtained by the above method, for treating or preventing of sufferings of the human or animal body comprising 30-20000 pg/ml of interleukin(IL)-6. ACTIVITY : Muscular-Gen; Antiallergic; Immunomodulator; Antipsoriatic; Antidiabetic; Antiulcer; CNS-Gen; Anabolic; Vulnerary. MECHANISM OF ACTION : None given.
Patent CY-1112267-T1 (CY)
Title: Νεα πεπτιδια ως αναστολεις πρωτεασης ns3-σερινης του ιου ηπατιτιδας c
Inventor: SAKSENA ANIL K
IPC: A61K38/08
Filed: 2010-06-16
Abstract: Η παρούσα εφεύρεση αποκαλύπτει νέες ενώσεις, οι οποίες έχουν ανασταλτική δραστικότητα πρωτεάσης HCV καθώς επίδης μεθόδους για παρασκευή τέτοιων ενώσεων. Σε άλλη πραγματοποίηση η παρούσα εφεύρεση αποκαλύπτει φαρμακευτικές συνθέσεις που περιλαμβάνουν τέτοιες ενώσεις, καθώς επίσης μεθόδους χρήσης αυτών για να θεραπεύονται διαταραχές που συνδυάζονται με την HCV πρωτεάση.
Patent CY-1110918-T1 (CY)
Title: Σκευασμα για την προφυλαξη απο την επαναστενωση
Inventor: SPECK ULRICH
IPC: A61M25/10
Filed: 2010-06-25
Abstract: Η ευρεσιτεχνία αφορά ένα σκεύασμα για την προφύλαξη από την επαναστένωση. Στα σκευάσματα για την προφύλαξη της επαναστένωσης, τα οποία είναι γνωστά μέχρι σήμερα δεν μπορεί να επιτευχθεί στα πληγέντα τμήματα των τοιχωμάτων των αιμοφόρων αγγείων επαρκής συγκέντρωση της δραστικής ουσίας, καθώς οι υψηλότερες δόσεις προκαλούν ανεπιθύμητες ενέργειες. Σύμφωνα με την παρούσα ευρεσιτεχνία προστίθεται σε ένα σκεύασμα τουλάχιστον μια λιπόφιλη, αντι-υπερπλασική δραστική ουσία, η οποία έχει έναν συντελεστή κατανομής μεταξύ βουτανόλης και νερού ≥ 0,5. Η λιπόφιλη δραστική ουσία λαμβάνεται γρήγορα και σε επαρκείς ποσότητες από τα τοιχώματα των αιμοφόρων αγγείων. Το σκεύασμα μπορεί να είναι ρευστό και προσβάσιμο μέσω των τριχοειδών αγγείων, και μπορεί να περιέχει ένα σκιαγραφικό μέσο, έτσι ώστε κατά τις σκιαγραφικές απεικονίσεις που απαιτούνται κατά κανόνα, η μετάβαση της δραστικής ουσίας στο τοίχωμα του αγγείου να λαμβάνει χώρα χωρίς πρόσθετη δαπάνη. Το σκεύασμα μπορεί επίσης να εισαχθεί σε έναν καθετήρα.
Patent CY-1111136-T1 (CY)
Inventor: ROSSOMANDO ANTHONY
IPC: A61K38/00
Filed: 2010-10-20
Abstract: Variant Neublastin polypeptides having substitutions at selected amino acid residues are disclosed. Substitution at one or more selected amino acid residues decreases heparin binding and increases serum exposure of variant Neublastin polypeptides. Also disclosed are methods of using variant Neublastin polypeptides to treat disorders and activate the RET receptor in a mammal.
Patent CY-1111443-T1 (CY)
Inventor: KITAHARA YOSHIRO
IPC: A61P43/00
Filed: 2011-01-27
Abstract: The present invention provides a pharmaceutical composition for suppression of the expression of ATP citrate lyase, which contains a compound that suppresses the expression of ATP citrate lyase by the in vivo administration. The compounds suppress the expression of ATP citrate lyase by the in vivo administration include insulin secretagogues such as nateglinide. This pharmaceutical composition is effective in preventing, improving and treating metabolic syndrome, in particular, liver disorders related to abnormal lipid metabolism such as fatty liver and NASH.
Patent CY-1113015-T1 (CY)
Inventor: MATUSCHKA-GREIFFENCLAU MARKUS GRAF VON
IPC: A23L33/155
Filed: 2012-06-12
Abstract: The present invention is directed to a composition of matter, in particular a food composition, dietary or food supplementation, and pharmaceutical composition, respectively. The composition of matter reduces the risk of neuropathy, neurodegenerative diseases including late-onset Alzheimer's disease, and cancer, in particular of pancreatic, esophageal, oropharyngolaryngeal, liver, colorectal, lung and/or breast cancer, in particular the drug and/or alcohol induced risk of said diseases. In this respect, the present invention is also directed to a composition of matter, in particular a food composition, dietary or food supplementation, and pharmaceutical composition, respectively, which supports and/or moderates the alcohol degradation process within the human body.
Patent CY-1115551-T1 (CY)
Title: Ανθρωπινα αντισωματα υψηλης συναφειας κατα του ανθρωπινου υποδοχεα il-4
Inventor: STEVENS SEAN
IPC: C07K16/28
Filed: 2014-08-07
Abstract: Απομονωθέν ανθρώπινο αντίσωμα ή θραύσμα αντισώματος αυτού που δεσμεύεται στον ανθρώπινο υποδοχέα ιντερλευκίνης-4 άλφα (hIL-4Rα) με σταθερά συναφείας (Κ0) μικρότερη από 200 pM, όπως μετράται δια συντονισμού επιφανειακών πλασμονίων.
Patent CY-1115904-T1 (CY)
Title: Συνθεσεις και μεθοδοι για την προληψη και τη θεραπεια του βακτηριακου καψιματος
Inventor: ABELE ULF
IPC: A01P1/00
Filed: 2015-01-15
Abstract: Η εφεύρεση αφορά τις ενώσεις που μπορούν να χρησιμοποιηθούν για τη θεραπεία ή/και την πρόληψη του βακτηριακού καψίματος στα φυτά ή στα μέρη των φυτών, τις μεθόδους για την παραγωγή αυτού, τα συμπυκνώματα για την παραγωγή των ενώσεων, και τις χρήσεις και τις μεθόδους που βασίζονται στις ενώσεις.
Patent CY-1116541-T1 (CY)
Title: Παραγωγα 2-(2-υδροξυδιφαινυλο-3-υλο)-1η-βενζοϊμιδαζολο-5-καρβοξαμιδινης ως αναστολεις του παραγοντα viia
Inventor: KOLESNIKOV ALEKSANDR
IPC: C07D407/12
Filed: 2015-07-29
Abstract: Η παρούσα εφεύρεση σχετίζεται με μια καινοτόμο ένωση αναστολέων Τύπου I των παραγόντων Vlla, ΙΧα, Χα, ΧΙα, ιδιαίτερα του παράγοντα Vlla, τις φαρμακευτικές συνθέσεις που περιέχουν αυτούς τους αναστολείς και τις μεθόδους χρήσης αυτών των αναστολέων για τη θεραπεία ή την πρόληψη θρομβοεμβολικών διαταραχών, καρκίνου ή ρευματοειδούς αρθρίτιδας. Περιγράφονται επίσης οι διαδικασίες παρασκευής αυτών των αναστολέων.
Patent CY-1116736-T1 (CY)
Title: Συντηγμενες ετεροαρωματικες πυρρολιδινονες ως αναστολεις syk
Inventor: ARIKAWA YASUYOSHI
IPC: A61P37/00
Filed: 2015-08-26
Abstract: Γνωστοποιούνται ενώσεις του Τύπου I, και φαρμακευτικά αποδεκτά άλατα αυτών, όπου τα G, L1, L2, R1, R2, R3 και R4 ορίζονται στην προδιαγραφή. Αυτή η γνωστοποίηση επίσης σχετίζεται με υλικά και μεθόδους παρασκευής ενώσεων του Τύπου I, φαρμακευτικές συνθέσεις που τα περιέχουν, και την χρήση τους για την θεραπεία διαταραχών, νόσων και καταστάσεων που εμπλέκουν το ανοσοποιητικό σύστημα και με φλεγμονή, συμπεριλαμβανομένων ρευματοειδούς αρθρίτιδας, αιματολογικών κακοηθειών, επιθηλιακών καρκίνων (δηλ. καρκινωμάτων), και άλλων διαταραχών, νόσων και καταστάσεως, για τις οποίες ενδείκνυται η αναστολή της SYK.
Patent CY-1117106-T1 (CY)
Title: Ασυμμετρα διμερη πυρρολοβενζοδιαζεπινης για τη θεραπευτικη αντιμετωπιση των πολλαπλασιαστικων ασθενειων
Inventor: HOWARD PHILIP WILSON
IPC: C07D487/04
Filed: 2016-01-11
Abstract: Αξιώνονται τα ασύμμετρα διμερή πυρρολοβενζοδιαζεπίνης (διμερή PBD) του τύπου (I), τα οποία είναι ασύμμετρα λόγω τουλάχιστον των τιμών που αντιπροσωπεύουν οι μεταβλητές R12 και R2. Τύπος (I), όπου: το R2 είναι του τύπου (II), όπου το Α είναι μια ομάδα C5-7 αρυλίου, το Χ επιλέγεται από την ομάδα που περιλαμβάνει: OH, SH, CO2H, COH, N=C=O, NHRN, όπου το RΝ επιλέγεται από την ομάδα που περιλαμβάνει Η και C1-4 αλκύλιο και (OC2H4)mOCH3, όπου το m είναι 1 έως 3 και είτε: (i) το Q1 είναι ένας μονός δεσμός και το Q2 επιλέγεται από έναν μονό δεσμό και -Z-(CH2)n-, όπου το Z επιλέγεται από έναν μονό δεσμό, Ο, S και ΝΗ και το n είναι από 1 έως 3 ή (ii) το Q1 είναι -CH=CH- και το Q2 είναι ένας μοναδικός δεσμός, το R12 είναι μια ομάδα C5-10 αρυλίου, που υποκαθίσταται προαιρετικά με ένα ή περισσότερα υποκατάστατα που επιλέγονται από την ομάδα που περιλαμβάνει: αλογόνο, νίτρο, κύανο, αιθέρα, C1-7 αλκύλιο, C3-7 ετεροκυκλύλιο και δις-οξυ-C1-3 αλκυλένιο. Οι άλλες μεταβλητές είναι όπως ορίζονται στις αξιώσεις. Οι ενώσεις είναι χρήσιμες στη θεραπευτική αντιμετώπιση των πολλαπλασιαστικών παθήσεων.
Patent CY-1118593-T1 (CY)
Title: Πρωτοτυπα παραγωγα πυραζινης
Inventor: BISSANTZ CATERINA
IPC: C07D417/14
Filed: 2017-02-02
Abstract: Η εφεύρεση σχετίζεται με ενώσεις του τύπου (I), όπου τα R1 έως R4 ορίζονται στην περιγραφή και στις αξιώσεις. Η ένωση του τύπου (I) μπορεί να χρησιμοποιηθεί ως φάρμακο.