baber/WOPTO huggingface dataset:
Patent PT-1313481-E (PT)
Title: Pharmaceutical composition comprising condensed indole compound
Inventor: BUXTON PHILIP CHRISTOPHER
IPC: A61P9/00
Filed: 2001-08-08
Abstract: A pharmaceutical composition comprising N-[(1- n butyl-4-piperidinyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide (SB 207266) or a pharmaceutically acceptable salt thereof in combination with one or more pharmaceutically acceptable carriers, wherein at least some of the SB 207266 or the salt thereof is in granulated form.  Preferably, a filler and/or binder are also present.  The invention also provides a method of making a pharmaceutical composition comprising N-[(1- n butyl-4-piperidinyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide (SB 207266) or a pharmaceutically acceptable salt thereof in combination with one or more pharmaceutically acceptable carriers, the method comprising forming at least some of the SB 207266 or the salt thereof into granules.  Preferably, the granules are formed in the presence of a granulating solvent, i.e. using a "wet granulation" process.
Patent PT-1335860-E (PT)
Title: Carton with article dispenser
IPC: B65D5/462
Filed: 2001-11-14
Abstract: A carton, comprising a bottom wall; a pair of opposed side walls, each having an upper and a lower edge and each being connected along said lower edge to said bottom wall; a bottom end flap hingedly connected along an end edge of said bottom wall and extending upwardly from said bottom wall; a side end flap hingedly connected to each of said side walls along a corner fold line and disposed along at least a part of an outside surface of said bottom end flap, said side end flaps extending from said side walls toward each other and being secured together in an overlapping relationship; and an article dispenser including a detachable tear panel defined by a tear line, said tear line comprising: a side wall section formed in one of said side walls and extending from a first point near said lower edge of said one side wall to a second point spaced apart from said side end flaps and to a third point along said corner fold line between said one side wall and an adjacent one of said side end flaps; and an end wall section formed in said side end flaps and extending from said third point toward said bottom wall.
Patent PT-1494680-E (PT)
Title: Use of carbon-2-modified-vitamin d analogs to induce the formation of new bone
Inventor: DELUCA HECTOR F
IPC: A61K31/59
Filed: 2003-03-12
Abstract: It has been discovered that the 2-carbon-modified derivatives of 1α,25-dihydroxyvitamin D3 specifically stimulate osteoblasts to form new bone. The ability of the 2-carbon-modified vitamin D analogs to stimulate new bone formation suggest that these compounds can be used where synthesis of new bone is required. Thus, these compounds can be used either systemically or locally to stimulate the growth of bone transplants, to increase the rate of fracture healing and thereby reduce the time required for the healing of fractures, the stimulation of bone growth when required for replacement surgery, and also for the growth of bone to implants or other devices required to maintain the skeleton or teeth in the proper positions.
Patent PT-1558649-E (PT)
Title: Peptid modulating caspase activation
Inventor: KORPELA TIMO KALEVI
IPC: C12N5/0793
Filed: 2003-10-07
Abstract: The present invention provides structures of small molecules capable of modulating apoptotic cell death. More specifically, the structures relate to the structures of apoptotic active sites of mammalian alpha-fetoprotein (AFP) and albumin. Peptides mimicking the active site contain two sequences, Arg-Gly-Asp and Asp-X-X-Asp, wherein X means any amino acid. These sequences are needed in the same molecule for causing a wide range of biological activities. The peptides can be utilized to suppress apoptotic pathways by inhibiting the cytochrome c-mediated caspase activation. Thus, the peptides can be used to inhibit effects of apoptosis induced by oxidative stress, drugs, cytokines, Fas-ligand, alpha-fetoprotein, used to prevent apoptosis in culturing cells, in organ transplantation, in immunological autoimmune disorders and immunodeficiency syndrome induced by viral infection, or to diminish side cytotoxic effects after chemotherapy and radiation therapy.
Patent PT-1530509-E (PT)
Inventor: JUERGEN HEESEMANN
IPC: B24B7/02
Filed: 2003-07-22
Abstract: Disclosed is a grinding machine comprising oscillating driving means ( 3, 4 ) for setting grinding means ( 1 ) into an oscillating grinding motion and an actuation device ( 7 ) that is provided with a plurality of actuation areas ( 8 ) which can be triggered such that different zones of the grinding means ( 1 ) are alternately actuated independently of the oscillating grinding motion.
Patent PT-1504764-E (PT)
Title: Treatment of liver fibrosis with antibodies against alpha v beta 6 integrin
Inventor: HUANG XIAOZHU
IPC: C07H21/04
Filed: 1998-08-07
Abstract: Use of an antibody that specifically binds to integrin ±v²6 and blocks binding of a ligand to integrin ±v²6 for the manufacture of a medicament for treating bladder fibrosis in a patient.
Patent PT-1527721-E (PT)
Title: Immersion device for heating a liquid
Inventor: CARBONINI CARLO
IPC: A47J31/44
Filed: 2004-10-28
Abstract: An immersion device (1) for heating a liquid according to the invention comprises a tube (3) connected at one of its ends to a source of a high temperature aeriform substance, and provided an the other of its end of one or more nozzles (11) suitable for injecting said aeriform substance in said liquid. According to the invention, the external surface of said tube (3) comprises a covering (5) made of thermally insulating material that prevents encrustings due to the cooling of the overheated liquid on the external surface of the device.
Patent PT-1682180-E (PT)
Title: Antagonist anti-cd40 monoclonal antibodies and methods for their use
Inventor: LUQMAN MOHAMMAD
IPC: A61K38/20
Filed: 2004-11-04
Abstract: Methods of treating a subject for a cancer comprising neoplastic cells expressing the CD40 cell surface antigen are provided. The methods comprise combination therapy with interleukin-2 (IL-2) or biologically active variant thereof and at least one antagonist anti-CD40 antibody or antigen-binding fragment thereof. In some embodiments, these two therapeutic agents are concurrently administered as two separate pharmaceutical compositions, one containing IL-2 or biologically active variant thereof, which is administered according to a constant IL-2 dosing regimen or a two-level IL-2 dosing regimen, the other containing the antagonist anti-CD40 antibody or suitable antigen binding fragment thereof, which is administered according to a weekly dosing regimen, or alternatively is dosed once every two, three, or four weeks.; Administering of these two agents together potentiates their effectiveness in promoting a positive therapeutic response. The methods find use in treating CD40-expressing cancers, including B-cell related cancers and solid tumors.
Patent PT-1600138-E (PT)
Title: Drain
Inventor: VIEGENER WALTER
IPC: E03C1/22
Filed: 2005-04-21
Abstract: The drain has a bath-mounted intake (2) with cover (3), connected via a low-pressure chamber (9) to an intake pipe (10). The chamber and a drain (12) below it, are connected via a channel controlled by a valve cone (11). The cone is moveable independently of the cover, and is moved in opposite directions by pressure and traction, by a movement mechanism. The valve cone has a disc-shaped part with ring seal, which engages on a wall of the channel between low-pressure chamber and drain. The intake has ribs (4) arranged in a ring, to catch hairs.
Patent PT-1641389-E (PT)
Title: Apparatus and method for measuring hemodynamic parameters
IPC: A61B5/0285
Filed: 2005-02-16
Abstract: The hemodynamic parameters measuring apparatus (10) has signal detector (1) of sampling rate 200/heart cycle and storage unit (5) of 9-bit resolution. A digital anti-filter (8) compensates distortions occurring during sampling, separation and digitization of signal. An amplitude calculation unit (6) determines the augmentation index of the digitized signal, while a synthesizing unit (9) determines the ejection duration. An independent claim is also included for hemodynamic parameters measuring method.
Patent PT-1733056-E (PT)
Title: Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments
Inventor: SETTLEMAN JEFFREY E
IPC: C12Q1/48
Filed: 2005-03-31
Abstract: The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug.
Patent PT-1779841-E (PT)
Title: Cosmetic composition comprising an oxyethylenated sorbitan ester, a cationic polymer and a solid fatty material
Inventor: MEZURE PATRICIA
IPC: A61K8/34
Filed: 2006-09-29
Abstract: Cosmetic composition (A) comprises, in an aqueous medium, at least one each of: (i) ester (I) of ethoxylated sorbitan (not over 20 ethylene oxide (EO) units) with a 8-30C (un)saturated, linear or branched fatty acid; (ii) a non-silicone cationic polymer (CP) with cationic charge density at least 4 meq/g and (iii) a solid, non-silicone fatty body (FB).
Patent PT-2195769-E (PT)
Title: Method based on a sim card performing services with high security features
Inventor: FUCCI FRANCESCO
IPC: G06Q20/00
Filed: 2008-10-03
Abstract: The present invention relates to a method for the secure and rapid performance of banking, economic, financial and postal operations via a mobile telephone terminal and by sending SMS text messages. The invention also relates to a SIM card capable of implementing the method.
Patent PT-2203013-E (PT)
Title: Methods and apparatus related to custom control channel reporting formats
Inventor: LI JUNYI
IPC: H04W24/10
Filed: 2006-12-20
Abstract: Methods and apparatus related to control information reporting over wireless communication channels are described. Various embodiments include communicating control information format definition information over a wireless link. For example, in some embodiments, a base station downloads control information reporting format definition information, e.g., corresponding to a new release or a custom reporting format, into a wireless terminal. As another example, a wireless terminal generates a custom control information reporting format, that it intends to use, and communicates definition information corresponding to the generated custom control reporting format to a base station.
Patent PT-564945-E (PT)
Inventor: ISONO KUNIHIRO
IPC: A01N25/00
Filed: 1993-03-29
Abstract: The present invention relates to a process for the treatment of individual plants with solid shaped plant treatment agents which are introduced into the sap conduction paths of the plants, new solid shaped plant treatment agents and their production.
Patent PT-686053-E (PT)
Inventor: WIJDEVEN GIJSBERDUS GERARDUS P
IPC: A61M36/00
Filed: 1993-05-13
Abstract: PCT No. PCT/NL93/00098 Sec. 371 Date Jan. 9, 1995 Sec. 102(e) Date Jan. 9, 1995 PCT Filed May 13, 1993 PCT Pub. No. WO93/23110 PCT Pub. Date Nov. 25, 1993The present invention relates to a method and a device for injecting humans and animals with a pharmaceutical preparation, wherein the preparation is held in a rigid carrier (5) and the carrier is carried through the skin into the body by means of gas pressure, and wherein during carrying of a rigid carrier (5) into the body by means of gas pressure the device with which the carrier is carried into the body is held against the body. The invention likewise relates to a device for injecting animals or humans with a pharmaceutical preparation, wherein a chamber (2) is present in which a carrier (5) containing the pharmaceutical preparation can be placed, a barrel (1) connecting onto this chamber and means for carrying the carrier by means of gas pressure through the barrel into the body for injecting, wherein means are present for blocking the use of the device when it is not pressed against a body.
Patent PT-638316-E (PT)
Inventor: HUNG PAUL PORWEN
IPC: A61K/
Filed: 1994-07-29
Abstract: This invention provides a method of producing antibodies or cell mediated immunity to an infectious organism in a warm blooded mammal which comprises administering to said warm blooded mammal intranasally, intramuscularly, or subcutaneously, live recombinant adenoviruses in which the virion structural protein is unchanged from that in the native adenovirus from which the recombinant adenovirus is produced, and which contain the gene coding for the antigen corresponding to said antibodies or inducing said cell mediated immunity.
Patent PT-627388-E (PT)
Inventor: DURAND JEAN-PIERRE
IPC: C03B5/43
Filed: 1994-04-14
Abstract: Process for the vitrification of solid residues, a device for making use of this process and the product resulting from this process. According to this vitrification process the residues are heated to a temperature not much higher than their melting temperature and, once molten, the products are rapidly removed in order to keep them in the viscous state to trap substances capable of contaminating the environment. This process and this device find application in all fields in which it is desirable to maintain a temperature not much higher than the desired treatment temperature and in particular they find application for the treatment of solid residues produced by the incineration of household and/or industrial waste.
Patent PT-748382-E (PT)
Inventor: MATULIC-ADAMIC JASENKA
IPC: C12N9/00
Filed: 1994-08-19
Abstract: The invention relates to enzymatic nucleic acid molecules having enzymatic activity to cleave a target RNA molecule, wherein said enzymatic nucleic acid molecule comprises one or more abasic moieties in a single-stranded region of said enzymatic nucleic acid molecule.
Patent PT-691130-E (PT)
Inventor: MORRIS RANDALL ELLIS
IPC: A61K31/395
Filed: 1995-05-10
Abstract: This invention provides a method of preventing hyperproliferative vascular disease in a mammal by administering an antiproliferative effective amount of rapamycin alone or in combination with mycophenolic acid.
Patent PT-776253-E (PT)
Inventor: JEFFRIES ANDREW
IPC: B05B5/053
Filed: 1995-09-19
Abstract: PCT No. PCT/GB95/02218 Sec. 371 Date Apr. 2, 1997 Sec. 102(e) Date Apr. 2, 1997 PCT Filed Sep. 19, 1995 PCT Pub. No. WO96/10459 PCT Pub. Date Apr. 11, 1996A method and device (20) for spraying particulate materials in which a high voltage is applied to a mass of the particulate material so as to cause particles to issue from the mass. High voltage from a source (16) is applied to a mass of material (36) stored in a container. A surface of the mass (36) is exposed to the surroundings and the applied voltage is conducted through the bulk material to particles located at the exposed surface which are thereby projected as an electrically charged spray from the mass under the influence of the electric field substantially without any accompanying corona discharge.
Patent PT-786998-E (PT)
Inventor: MARKWELL ROGER EDWARD
IPC: C07D453/02
Filed: 1995-10-17
Abstract: PCT No. PCT/EP95/04082 Sec. 371 Date Apr. 25, 1997 Sec. 102(e) Date Apr. 25, 1997 PCT Filed Oct. 17, 1995 PCT Pub. No. WO96/12486 PCT Pub. Date May 2, 1996A method of enhancing amyloid precursor protein processing along a non-amyloidogenic pathway in patients suffering from, or at risk of developing, Alzheimer's disease and a method of treatment or prophylaxis of Alzheimer's disease by reducing  beta A4 production in patients suffering from, or at risk of developing, Alzheimer's disease comprising administering to the patient an effective, non-toxic amount of an acetonitrile compound, use of the compound in preparation of a medicament for use in the method and a composition for use in the method.
Patent PT-813419-E (PT)
Inventor: WALLACH DAVID
IPC: C12P21/08
Filed: 1996-02-15
Abstract: A modulator of regulatory cellular events occurring intracellularly which are mediated by regulatory proteins containing a "death domain" motif is provided. The "death domain" is a regulatory portion of the regulatory proteins, and the modulator is capable of interacting with one or more "death domain" motifs contained in the regulatory proteins and affecting the regulatory action of one or more of the regulatory proteins. The modulator preferably is capable of interacting with "death domain" motifs with p55-TNF-R, FAS/APO1-R, NGF-R, MORT-1, RIP, TRADD, or ankyrin, as illustrated in the Figure. A method for producing the modulators is also provided. The modulators are useful for modulating functions mediated in cells by proteins containing the "death domain".
Patent PT-833834-E (PT)
Inventor: WATSON MARK A
IPC: C12Q1/68
Filed: 1996-05-31
Abstract: A purified and isolated DNA sequence and the encoded mammary-specific protein, mammaglobin, are disclosed. Also disclosed are methods for the detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin.
Patent PT-858436-E (PT)
Inventor: DOUMET JOSEPH E
IPC: F27D15/02
Filed: 1996-07-29
Abstract: PCT No. PCT/IB96/00956 Sec. 371 Date Jan. 12, 1998 Sec. 102(e) Date Jan. 12, 1998 PCT Filed Jul. 29, 1996 PCT Pub. No. WO97/16390 PCT Pub. Date May 9, 1997The invention is related to a method and an apparatus for producing cement clinker, in which the cement clinker is first of all burnt in a burning zone and then cooled in a cooling zone, wherein the cooling takes place at least partially by the delivery of fuel and steam, characterised in that in a first cooling phase the delivered fuel is mixed with the cement clinker and initially pyrolysed and the resulting pyrolysis products have a strong endothermic reaction with the steam, so that the cement clinker is quenched in such a way that at least 95%, preferably all, of the liquid phase contained therein is transformed into glass.
Patent PT-911336-E (PT)
Inventor: CHIBA KATSUMI
IPC: C07D491/04
Filed: 1997-02-25
Abstract: This invention relates to pyridonecarboxylic acid derivatives of the following general formula, esters thereof and salts thereof, as well as pharmaceutical preparations containing them. <CHEM>  wherein:     R is cycloalkyl which may be substituted by halogen, or the like;   X is hydrogen, lower alkyl, amino or the like;   Y is hydrogen or halogen; A is nitrogen or a group of the formula C-Z in which Z is lower alkoxy that may be substituted by halogen, or the like; R1 and R2 may be the same or different and are each hydrogen or the like;   R3 is hydrogen or lower alkyl; R4, R5, R6, R7, R8 and R9 may be the same or different and are each hydrogen, halogen or lower alkyl;   m is 0 or 1; and   n and p may be the same or different and are each 0 or 1. This invention also relates to bicyclic amine compounds useful as direct intermediates for the synthesis of the above-described pyridonecarboxylic acid derivatives.
Patent PT-920502-E (PT)
Inventor: WILHELMUS LIER RENE ANTONIUS V
IPC: C12N15/02
Filed: 1997-08-11
Abstract: A method for regulating immunological interaction comprising inhibiting the binding between cells bearing CD55 protein and activated leucocytes bearing CD97 protein.
Patent PT-991761-E (PT)
Title: Novel mutants of gram negative mucosal bacteria and application thereof in vaccines
Inventor: LEY PETER ANDRE VAN DER
IPC: C07K14/22
Filed: 1997-08-21
Abstract: It is possible to inactivate the early stage of lipid A synthesis of mucosal gram negative bacteria without compromising cell viability. In particular the lpxA gene in N. meningitidis was mutated and resulting lpxA knockout mutants were found to be completely lipopolysaccharide (LPS)-deficient. The major outer membrane proteins (OMPs) were detected in normal amounts. The finding provides important implications for understanding of structure and biogenesis of the outer membrane. On a practical level, the availability of LPS-deficient mutants of pathogenic mucosal bacteria such as N. meningitidis opens up new avenues to vaccine development. It enables easy isolation of endotoxin-free purified proteins, outer membranes or even whole-cell preparations for use in immunisation.
Patent PT-1032606-E (PT)
Inventor: CHOU YUETING
IPC: A61L15/60
Filed: 1998-11-18
Abstract: Superabsorbent polymer compositions comprising a fiber-containing composition derived from cellulosic fibers, synthetic fibers or mixtures thereof which is at least partially coated with a partially hydrolyzed, internally plasticized, crosslinked, superabsorbing polymer derived from polysuccinimide and processes for preparing same.
Patent PT-999152-E (PT)
Inventor: HANNESSEN PIETER GERRIT
IPC: B65G17/18
Filed: 1999-11-01
Abstract: A device for transferring goods from one conveyor of random nature to another, comprising a frame, endless transporting means supported therein and at least one carrier connected thereon, wherein the carrier is connected to the endless transporting means for rotation on a lying shaft and means are provided for holding the carrier horizontal, so that goods can be transferred in a random path from the one conveyor to the other. <IMAGE>
Patent IE-780043-L (IE)
Title: Food impregnation
IPC: A23B5/00
Filed: 1978-01-06
Abstract: The continuous impregnation method, in which pieces of a food material to be impregnated are immersed in a concentrated solution of an impregnating agent, these pieces being initially light and floating in the solution and following, with this solution, a path leading to a zone of separation where the impregnating solution flows downwards at a faster speed than the flow speed of the food material, so that the pieces of food material which, by absorption of the desired quantity of the impregnating agent, have lost sufficient of their lightness or floatability in the surrounding impregnating solution to be removed downwards by this solution, are thus continually separated from the pieces of food material which have absorbed less than the desired quantity of the impregnating agent, applies to a food material chosen from meat, eggs, fish or textured vegetable proteins.
[GB1538686A]
Patent IE-830078-L (IE)
Title: Tetrazolylquinazolinones
IPC: C07D405/12
Filed: 1983-01-17
Abstract: 3-(1H-tetrazol-5-yl)-4(3H)-quinazolinones useful as antiallergic agents are described herein. The compounds are prepared by the reaction of an appropriate 2-amino-N-(1H-tetrazol-5-yl)benzamide with an appropriate ortho ester.
Patent IE-38842-L (IE)
Title: Shaped structures of acrylonitrile polymers containing¹polymeric antistatic additives
IPC: C08K5/205
Filed: 1974-02-12
Abstract: Shaped structures of 85 - 99.5 percent by weight of an acrylonitrile polymers and 0.5 - 15 percent by weight of an antistatic additive being a polyether urethane compound of the general formula . (From US3852255 A) [FR2217366A1]