Patent SG-11201408691X-A (SG)
Title: Novel rebamipide prodrug, method for producing same, and usage thereof
Inventor: BALARAM PADINJARETHALAKKAL NANU EZUTHASSAN
IPC: C07D207/38
Filed: 2012-07-02
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 9 January 2014 (09.01.2014) WIPOIPCT (10) International Publication Number WO 2014/006629 A1 (51) International Patent Classification: C07D 207/38 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/IN2012/000469 2 July 2012 (02.07.2012) English English (71) Applicant (for all designated States except US): PNB VESPER LIFE SCIENCE PVT LIMITED [IN/IN]; A Company Registered Under The Laws Of India, 5th Floor, Amrita Towers, Mahatma Gandhi Road, Cochin 682011 Kerala (IN). (72) Inventors; and (75) Inventors/Applicants (for US only): BALARAM, Padin- jarethalakkal Nanu Ezuthassan [IN/IN]; Director, PNB Vesper Life Science P. Ltd., NO.4 . Nirmalyam, Perigavu, Thrissur 680022, Kerala (IN). LATTMANN, Pornthip [GB/GB]; 11, KelletRoad, Birmingham, B 74 NQ, West Midlands (GB). (74) Agent: JAPEE, Arun, P.; 17/3 Brightons Road, Perambur Barracks P.O., Chennai 600012 (IN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) (54) Title: NOVEL CHOLECYSTOKININ RECEPTOR LIGANDS o\ CJ o o o CJ o & (I) (57) Abstract: The present invention relates to novel compounds of formula (I): wherein X is selected from hydrogen, a halogen, or a substituent and R is selected from hydrogen, a halogen, phenyl, aryl as specified and Y is selected from H, hydroxy, as specified and R is 1 selected from H, methyl, alkyl, Ci-is straight, branched or cyclic, saturated, unsaturated and aromatic hydrocarbyl groups, which aromatic groups may be heterocyclic, cyclic or acyclic and which may optionally be substituted by alkyl, alkynyloxycarbonyl, aryl, benzyl, arlyoxy, arylcarbonyl, aryloxycarbonyl, sulphur equivalents of said oxy, carbonyl and oxycarbonyl moieties, and oxo as specified. The invention also relates to their uses as CCK receptor ligands and CCK antagonists and their medicinal applications.