Patent SG-11201807977X-A (SG)
Title: Cancer therapy with an oncolytic virus combined with a checkpoint inhibitor
Inventor: LEUCHS BARBARA
IPC: A61K35/768
Filed: 2017-03-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111110111101110101011111 HO EOM 0111 10011111110111 I 111E1111 MI International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date .... ...,,, 5 October 2017 (05.10.2017) IN I PO I P CT WO 2017/167626 Al (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 39/00 (2006.01) A61K 35/768 (2015.01) kind A61K 39/395 (2006.01) AO, BZ, of national protection available): AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/EP2017/056886 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: KP, 22 March 2017 (22.03.2017) MD, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, ZA, ZM, ZW. TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (30) Priority Data: EP16163555.2 1 April 2016 (01.04.2016) EP (84) Designated States (unless otherwise indicated, for every EP16020193.5 27 May 2016 (27.05.2016) EP kind GM, of regional protection available): ARIPO (BW, GH, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicants: DEUTSCHES KREBSFORSCHUNG- TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) Inventors: LEUCHS, Barbara; SZENTRUM [DE/DE]; Im Neuenheimer Feld, 69120 TJ, Heidelberg (DE). RUPRECHT-KARLS-UNIVERSITAT DK, HEIDELBERG [DE/DE]; Grabengasse 1, 69117 Heidel- LV, berg (DE). SM, GW, KM, ML, MR, NE, SN, TD, TG). Handschuhsheimer Land- TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, — strasse 79, 69121 Heidelberg (DE). MARCHINI, Anto- Published: nio; Im Gabelacker 15, 69120 Heidelberg (DE). ROM- — MELAERE, Jean; SchioB Wolfsbrunnenweg 11, 69118 with international search report (Art. 21(3)) Heidelberg (DE). ANGELOVA, Assia; Bergheimerstr. 59, — before the expiration of the time limit for amending the = 69115 Heidelberg (DE). JAGER, Dirk; Hauptstr. 99, claims and to be republished in the event of receipt of 55246 Mainz-Kostheim (DE). WICK, Wolfgang; Schloss- amendments (Rule 48.2(h)) Wolfsbrunnenweg 1, 69117 Heidelberg (DE). — with sequence listing part of description (Rule 5.2(a)) = Agent: HUBER & SCHUSSLER; Truderinger Strasse (74) _ 246, 81825 Munich (DE). = = = = = = = = = = 1-1 ei IN 1-1 IN 1-1 0 \" (54) Title: CANCER THERAPY WITH AN ONCOLYTIC VIRUS COMBINED WITH A CHECKPOINT INHIBITOR C ) „,.. (57) : The present invention concerns a pharmaceutical composition where a checkpoint inhibitor is combined with an on - .,- colytic virus and the use of said combination for the treatment of cancer.