baber/WOPTO huggingface dataset:
Patent DK-1697403-T3 (DK)
Inventor: BAKALETZ LAUREN O
IPC: C07H21/04
Filed: 2004-12-21
Granted: 2010-07-05
Abstract: The invention described herein relates to  a Haemophilus influenzae (H. influenzae)  regulon encoding type IV pili. In particular, the invention relates to type IV pili from nontypeable  H. influenzae  (NTHi) and from  H. influenzae  strains a, b, c, e and f. The invention provides isolated  H. influenzae  pilus polynucleotides and polypeptides encoded by the polynucleotides as well as polynucleotides and polypeptides encoded by the polynucleotides involved in the assembly/disassembly of the structure. The invention also relates to uses of these polynucleotides and/or polypeptides including methods for eliciting an immune response to  H .  influenzae  and methods of treating and preventing  H. influenzae  related pathological conditions.
Patent DK-1642973-T3 (DK)
Inventor: GROSS JANE A
IPC: A61P31/04
Filed: 2000-01-07
Granted: 2009-11-02
Abstract: There is provided a fusion protein consisting of a first portion and a second portion joined by a peptide bond, wherein said first portion consists of an amino acid sequence selected from: (i) amino acid residues 25-104 of SEQ ID NO: 6; (ii) amino acid residues 34-66 of SEQ ID NO: 6; (iii) amino acid residues 71-104 of SEQ ID NO: 6; and (iv) amino acid residues 34-66 and 71-104 of SEQ ID NO: 6; and said second portion is an immunoglobulin heavy chain constant region. There is also provided an antibody or antibody fragment that specifically binds to a polypeptide selected from SEQ ID NO: 59 or SEQ ID N: 60. There is also provided an antibody or antibody fragment that specifically binds to a ztnf4 polypeptide, for use in treating systemic lupus erythematosus in a mammal.
Patent DK-1965773-T3 (DK)
Inventor: DIEZ MARTIN IGNACIO
IPC: A61K9/32
Filed: 2006-12-19
Granted: 2011-07-25
Abstract: A solid oral olanzapine formulation comprises a core of anhydrous olanzapine or its salt as active substance and optionally pharmaceutical excipients. The core is coated with a functional polymer that acts as filmogenic agent. A solid oral olanzapine formulation comprises a core of anhydrous olanzapine of formula (I) or its salt as active substance and optionally pharmaceutical excipients. The core is coated with a functional polymer that acts as filmogenic agent. An independent claim is included for preparation of solid oral formulation by providing anhydrous olanzapine (I) or its salt in solid form (e.g. tablet), preparing a dispersion of functional polymer in aqueous medium (e.g. water), and applying the dispersion to the solid form. [Image] ACTIVITY : Neuroleptic. No biological data given. MECHANISM OF ACTION : Antagonist on dopamine receptor D1-D5; of serotonin 5-HT2 and 5-HT3; alpha -1-adrenergic, cholinergic, and H1 histaminergic.
Patent DK-2241575-T3 (DK)
Title: IGF-1 fusion polypeptides and therapeutic uses thereof
Inventor: GLASS DAVID J
IPC: C07K19/00
Filed: 2006-01-06
Granted: 2015-08-24
Abstract: A fusion protein comprising at least one IGF1 variant component and a fusion component (F), and, optionally, a signal sequence, exhibiting improved stability relative to the native IGF1 or IGF2 polypeptide. The fusion component (F) may be a multimerizing component, a targeting ligand, or another active or therapeutic compound. IGF1 variants were shown to have improved ability to induce skeletal muscle hypertrophy relative to native IGF1.
Patent DK-2415776-T3 (DK)
Title: Beta-L-2'-deoxy nucleosides for the treatment of Hepatitis B
Inventor: BRYANT MARTIN L
IPC: C07H19/20
Filed: 1999-08-10
Granted: 2016-07-04
Abstract: This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active 2'-deoxy-²-L-rythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof, wherein the 2'-deoxy-²-L-erythro-pentofuranonucleoside has formula (I) wherein R is selected from the group consisting of H, straight chained, branched or cyclic alkyl, CO-alkyl, CO-aryl, CO-alkoxyalkyl, CO-aryloxyalkyl, CO-substituted aryl, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, amino acid residue, mono, di, or triphosphate, or a phosphate derivative; and BASE is a purine or pyrimidine base which may be optionally substituted. The 2'-deoxy-²-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof may be administered either alone or in combination with another 2'-deoxy-²-L-erythro-pentofuranonucleoside or in combination with another anti-hepatitis B agent.
Patent DK-2308543-T3 (DK)
Inventor: MURRAY MICHAEL
IPC: A61M25/00
Filed: 2007-06-08
Granted: 2013-07-29
Abstract: A catheter product package and method of forming same in which the package comprises a sheet material (14) wrapped about the catheter product (12) to form a package for the catheter product. The confronting proximal end edges (14a), distal end edges (14b) and side edges (14c) of the sheet material are joined by a seal after the sheet material is wrapped about the catheter product to define a sealed cavity (18). The sheet material has a tear strip (20) affixed to it which causes the sheet material to tear along the tear strip. A method of forming a package for a catheter product comprises the steps of providing a sheet material for the package and placing the catheter product on the sheet material. It also includes affixing a tear strip to the sheet material and wrapping the sheet material around the catheter product. Further, the method includes the step of sealing the sheet material to form a sealed cavity with the catheter product being disposed within the sealed cavity.
Patent DK-2603530-T3 (DK)
Inventor: FREIMOSER-GRUNDSCHOBER ANNE
IPC: C07K16/40
Filed: 2011-08-09
Granted: 2018-01-15
Abstract: The invention provides antibodies against Fibroblast Activation Protein (FAP) and methods of using the same.
Patent DK-3072886-T3 (DK)
Inventor: BISSANTZ CATERINA
IPC: C07D491/107
Filed: 2012-06-07
Granted: 2018-06-25
Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.
Patent DK-0402722-T3 (DK)
Inventor: MERKLE HANS RUPERT DR
IPC: C07D231/06
Filed: 1990-06-02
Granted: 1994-02-28
Abstract: Pyrazole and its derivs. (I) are produced by dehydrogenation of the corresp. 2-pyrazoline (II) with the aid of sulphuric acid in the presence of iodine or an iodine cpd. (III) at 50-250 deg.C. (II) is produced in situ in the reaction medium by reaction of glycerol or acrolein or a deriv. thereof with hydrazine or a hydrazine deriv.; amt. of (III) is 0.01-10 mol. equiv. w.r.t. (II) or the corresp. hydrazine; 30-99 wt.% H2SO4 is used.
Patent DK-0387952-T3 (DK)
Inventor: BERRENS LUBERTUS
IPC: A61K39/36
Filed: 1990-03-08
Granted: 1995-10-23
Abstract: Primary-toxic chemical compounds with a molecular weight of less than 12000 Daltons, which may be isolated from plant material and which are, or may become, potential IgE-binding allergens causing immediate-type allergy in predisposed individuals; methods for their isolation and their use for clinical purposes.
Patent DK-0477111-T3 (DK)
Inventor: BOUDRY JEAN-MICHEL
IPC: C08L25/00
Filed: 1991-09-05
Granted: 1995-11-06
Abstract: The matrix of which such a coating consists is an alloy comprising a styrene-based thermoplastic elastomer as a base, a styrene-based polymer as reinforcement and an olefinic polymer as plasticisation. The coverings thus obtained meet the use standards for a floor covering, can be calendered and exhibit good resistance to cigarette burns.
Patent DK-0488945-T3 (DK)
Inventor: NYFELER ROBERT DR
IPC: A01P3/00
Filed: 1991-11-13
Granted: 1996-04-01
Abstract: The combination of the plant microbicide 4-(2,2-difluoro-1,3-benzodioxol-7-yl)-1H-pyrrole-3-carbonitrile with the plant microbicide 1-{2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-ylme thyl}-1H-1,2,4-triazole results in a synergistically increased effect in the control of plant diseases. Microbicidal compositions based on such combinations are suitable for treating crops of plants and natural products of vegetable and animal origin, and for seed treatment.
Patent DK-0511232-T3 (DK)
Inventor: SCHWINN HORST
IPC: A01N57/12
Filed: 1991-01-10
Granted: 1994-11-14
Abstract: The invention relates to a process for removing viruses, in particular viruses with a phospholipid sheath, from biological fluids, in particular fluids containing proteins, by introducing dialkoxyphosphorus compounds, characterized in that the dialkoxyphosphorus compounds are used in the form of dialkoxyphosphorus compounds of formula (I): Tr-Spac(-O)n?PO(OAlk)2?, which can be separated mechanically and are bonded to carriers. In formula (I), Tr stands for an inert carrier, Spac stands for a spacer, n is equal to 0 or 1 and Alk stands for alkyl groups with 1 to 10 carbon atoms.
Patent DK-0483320-T3 (DK)
Inventor: REMOL JEAN POL
IPC: A61K9/20
Filed: 1991-05-16
Granted: 1995-01-30
Abstract: A pharmaceutical composition based on slow release granules designed to be orally administered. The composition includes a pharmacologically active substance and a pharmacologically acceptable excipient providing slow, even and stable release of said pharmacologically active substance after administration thereof. The excipient includes at least one mixture of low-viscosity ethylcellulose and high-viscosity ethylcellulose and the active substance is granulated with an alcoholic solution of the low-viscosity ethylcellulose, the weight ratio between the low- and high-viscosity ethylcellulose being from 1:5 to 1:20.
Patent DK-0495754-T3 (DK)
Inventor: MOCK ELMAR
IPC: B26B21/52
Filed: 1992-01-07
Granted: 1994-05-09
Abstract: The exchange cartridge (1) according to the invention for a razor with an applicator device has, next to a reservoir (2) for an application preparation, means for conveying the application preparation, for example a small pump (3) for manual operation, and a connection piece (10). The exchange cartridge is fixed, for example, by positive locking between the connection piece (10) and a counterpiece (4) on the razor. The interior space of the small pump (31) can be filled, in the new state of the exchange cartridge, with application preparation. Incorporating the small pump in the exchange cartridge (1) and its initial filling with preparation permits a simple construction of the pump, since the latter does not have to be designed for sucking in preparation, since it does not have to be accessible for cleaning purposes, and since it does not have to have a long life. A preferred embodiment of the pump consists of a pump space (31), the walls of which have elastically deformable points and two one-way valves (32 and 33). A preferred variant of the preparation reservoir consists of a hollow body, the interior space of which is divided up into a preparation space (22) and an air space (23) by a movable piston (21). 
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Patent DK-0500489-T3 (DK)
Inventor: OBERMEIER JOSEF
IPC: B23B31/22
Filed: 1992-01-22
Granted: 1996-01-02
Abstract: Rotational drivers (6, 7) of different radian measure are provided on a toolholder for hand held machines for transmitting a torque to the tool shank (8) of a tool. Corresponding rotational-driving grooves (9, 10), likewise of different radian measure, are provided on the tool shank (8). Locking members (4), capable of engaging radially into recesses (11, 12), closed on both sides, in the tool shank (8), serve for axial retention of the tool. By virtue of the asymmetric configuration of the rotational drivers (6, 7) and rotational-driving grooves (9, 10), it is possible to transmit a high torque while avoiding a damaging cross-sectional weakening of the tool shank (8). 
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Patent DK-0561880-T3 (DK)
Inventor: HEDDERLY DAVID LESLIE
IPC: H04B7/26
Filed: 1991-12-11
Granted: 1998-03-23
Abstract: In Multistation Demand Assigned Time Division Multiple Access Systems digital information is communicated from a head end to a population of oustations so that all the outstations receive the same stream of digital information and select their traffic from it. Traffic is only sent to and from an outstation when there is a demand for it. As the outstations are at random ranges from the head end it is necessary to know the time of travel for a burst of information so they arrive at the head end sequentially. The traffic dependent free time is consolidated and made available for ranging-in outstations.
Patent DK-0641164-T3 (DK)
Inventor: WILLIAMS GARETH
IPC: A01N59/06
Filed: 1992-08-03
Granted: 2000-05-08
Abstract: PCT No. PCT/GB92/01427 Sec. 371 Date Apr. 4, 1994 Sec. 102(e) Date Apr. 4, 1994 PCT Filed Aug. 3, 1992 PCT Pub. No. WO93/02557 PCT Pub. Date Feb. 18, 1993.The instant invention concerns a wood preservative composition comprising a synergistically effective amount of (a) a cuprammonium compound and (b) tebuconazole to preserve wood.
Patent DK-0609321-T3 (DK)
Inventor: IWATSCHENKO PETER
IPC: A23L33/175
Filed: 1992-10-21
Granted: 1996-06-03
Abstract: The soln. contains (A) known reducing sugar, and opt. other energy suppliers and/or electrolytes; and (B) in absence of amino acids (salts), pref. 0.01-50, esp. 0.05-5 g/l, N-acetylcysteine as stabiliser. The soln. pref. contains 2.5-70% glucose and/or fructose. The further energy supplier is a polyol and/or disaccharide. A multi-chamber or multi-compartment system comprises a chamber contg. an amino acid soln. and a chamber contg. the nutrient soln.
Patent DK-0610345-T3 (DK)
Inventor: STEPHEN A SHERWIN
IPC: A61K35/12
Filed: 1992-10-14
Granted: 2000-10-23
Abstract: Novel regimens are provided for administering foreign genetically modified allogeneic cells to a host by combining the administration of the cells with a reduced regimen of an immunosuppressive agent. Particularly, cells having a reduced level of Class I MHC antigens may be employed in a variety of cellular therapy situations, where foreign cells are engrafted to treat diseased states.
Patent DK-0554801-T3 (DK)
Inventor: SEIDEL RANDY R
IPC: B65H5/30
Filed: 1993-01-29
Granted: 1997-10-13
Abstract: A device for dividing a product such as a newspaper into two substantially equal portions, the device including a pocket assembly which receives the newspaper (fold down) when open. The pocket then closes and a retainer, at one corner of one pocket wall, prevents the extended portion of the newspaper from curling. A divider splits the newspaper into two portions, and the retainer then moves to a position wherein one of the portions is held between the retainer and the adjacent pocket wall. The pocket assembly is tilted so that the other portion of the newspaper falls away from the first portion as the pocket is opened. At the same time, the divider withdraws and another retainer, at the opposite corner from the first retainer, holds the corresponding corner of the first portion against the pocket wall. <IMAGE>
Patent DK-0572883-T3 (DK)
Inventor: FRITZ HUBERT
IPC: E04B1/90
Filed: 1993-05-22
Granted: 1997-04-21
Abstract: The wall comprises a wooden outer layer (6) and an inner layer (7). Between these layers, the insulation, comprising the layers (1) of mortar and the layers (2) of packed chips, is arranged. The layers (1, 2) are mutually supported. The wall achieves good insulation values in terms of sound insulation and heat insulation, and also an improvement in the fire retardation. <IMAGE>
Patent DK-0552958-T3 (DK)
Inventor: DE SANTANA GILDETE VITORIA
IPC: B65D41/34
Filed: 1993-01-21
Granted: 1997-09-22
Abstract: A closure cap, for a bottle or similar container having a treaded neck and especially for containing a carbonated beverage, which cap has internal screw threads (5) and at its lower edge a retaining band (8) which is interconnected to the bottom of the skirt (6) of the cap by a rupturable linear portion (11), said retaining band (11) having an annular inwardly directed projection (9), the lower face of which is substantially angled inwardly so as to allow the annular projection (9) to be forced over an annular collar on the neck of the bottle; and wherein the rupturable portion (11) of the skirt (6) has (a) a horizontal interrupted annular rupturable line (11), the interruptions (12) whereof which attach the band to the skirt being substantially smaller than the cut-through segments thereof apart from one interruption (12') which is at least twice preferably two to three times the length of the adjacent segments and (b) a vertically extending rupturable line (13,14) which extends from the lower edge of the band (11) and across said annular projection (9) and terminates adjacent to said longer interrupted segment (12') of the horizontal line; whereby upon turning of the closed cap the band (11) become detached from the cap except at said longer segment (12') and the detached band (7) extends downwardly from the open cap. The threads (5) can have gaps (16) for escape of Co2. The detached band (7) indicates if the container has been opened.
Patent DK-0581511-T3 (DK)
Inventor: MURRAY JOHN HUNTER
IPC: A47L23/22
Filed: 1993-07-19
Granted: 1997-07-07
Abstract: A dust control mat having a pile upper surface and a thermosetting rubber or rubber-like backing to which a thin thermoplastic identification strip or label has been vulcanized thereto <IMAGE>
Patent DK-0558373-T3 (DK)
Inventor: NAWROT SERGE
IPC: B29C48/32
Filed: 1993-02-16
Granted: 1996-02-05
Abstract: Tube, based on polyamide, for supplying petrol to engines, characterised in that it consists of an external layer of polyamide and of a internal layer of polyvinylidene fluoride joined together by an adhesive binder.
Patent DK-0582506-T3 (DK)
Inventor: WILLIAMS PAUL HOWARD
IPC: A61P25/28
Filed: 1993-07-27
Granted: 1996-07-15
Abstract: Compounds corresponding to the formula (I) <IMAGE>  in which   R1 represents either a halogen atom or a cyano group or a nitro group or a straight or branched (C1-C6)alkoxy group or a (C1-C6)cycloalkyl(C1-C2)alkoxy group or an aryl(C1-C2)alkoxy group, R2 represents either a (C1-C4)alkyl group or an aryl group optionally substituted by one or a number of methoxy groups or a pyridyl group or a benzodioxanyl group,   R3 represents either a hydrogen atom or a (C1-C2)alkyl group, and   n = 0 to 3,  and their addition salts with pharmaceutically acceptable acids. Application in therapeutics.
Patent DK-0559635-T3 (DK)
Inventor: LENK LEOPOLD
IPC: B61F3/12
Filed: 1993-03-04
Granted: 1995-08-21
Abstract: Rail vehicle in which in each case one floor component 20 or 21 projects from the adjacent ends of two successive wagons, of which floor components one 21 is semimounted on the other 20. Between the two floor components 20, 21, at least two concentric spherical joints 5a and 6a are arranged. <IMAGE>
Patent DK-0640195-T3 (DK)
Inventor: PARKES ADRIAN SYDNEY
IPC: F16L55/165
Filed: 1993-01-26
Granted: 2000-06-13
Abstract: A seal for use when inserting a first pipe into a second pipe while maintaining a flow of fluid through the second pipe, the seal being adapted for attachment to the leading portion of the first pipe to temporarily seal the first pipe during insertion of the first pipe to prevent fluid flow along the first pipe until the first pipe has been inserted. The seal has a rupturable membrane or removable plug 28 to temporarily seal the first pipe. Spacers 29 - 33 are provided to guide the seal in the second pipe, the spacers having apertures 34 to allow fluid to flow in the space between the pipes. Alternatively the spacers may be flexible to allow fluid flow. <IMAGE>
Patent DK-0637238-T3 (DK)
Inventor: FRIES HASTINGS BARBARA A
IPC: A61P27/02
Filed: 1993-04-23
Granted: 1999-08-30
Abstract: A method of treating macular degeneration is disclosed which comprises administering to a patient suffering from the disease a therapeutically effective amount of L-deprenyl or a pharmaceutically acceptable acid addition salt thereof for a period of time sufficient to ameliorate the disease.
Patent DK-0608773-T3 (DK)
Inventor: BROCK THOMAS DR
IPC: B05D5/06
Filed: 1994-01-21
Granted: 1999-04-06
Abstract: A process is described for the production of aqueous coating compositions having an adjustable effect by mixing two or more storage-stable, premixed aqueous modules (building blocks), in which process   A) at least one aqueous effect module, which contains one or more special-effect pigments, one or more anionically and/or nonionically stabilised, water-dilutable binders, one or more organic solvents, at least 20% by weight of water and, if desired, conventional coatings additives, is mixed with B) at least one aqueous binder module which contains one or more anionically and/or nonionically stabilised, water-dilutable binders, water and, if desired, one or more organic solvents, one or more crosslinking agents and/or conventional coatings additives.
Patent DK-0617133-T3 (DK)
Inventor: SANJUAN DIAZ CARLOS
IPC: C13B10/00
Filed: 1994-02-28
Granted: 2001-02-05
Abstract: A syrup consisting of the natural carob sugars and a process for its production. The syrup comprises 55-75% sucrose, 7-15% fructose, 7-16% glucose, 0.5-3% other sugars, 4-14% cyclitoles and 0.5-2 % organic and inorganic impurities. The procedure comprises the extracting of the sugars from the carob pulp and subjecting the juice thus obtained to chromatographic separation to separate the sugars from the non-sugars. The field of application of the product obtained is similar to those of other sugars.
Patent DK-0701694-T3 (DK)
Inventor: DOVICHI NORMAN J
IPC: G01N27/447
Filed: 1994-06-02
Granted: 1997-10-27
Abstract: A multiple capillary analyzer allows detection of light from multiple capillaries with a reduced number of interfaces through which light must pass in detecting light emitted from a sample being analyzed, using a modified sheath flow cuvette. A linear or rectangular array of capillaries is introduced into a rectangular flow chamber. Sheath fluid draws individual sample streams through the cuvette. The capillaries are closely and evenly spaced and held by a transparent retainer in a fixed position in relation to an optical detection system. Collimated sample excitation radiation is applied simultaneously across the ends of the capillaries in the retainer. Light emitted from the excited sample is detected by the optical detection system. The retainer is provided by a transparent chamber having inward slanting end walls. The capillaries are wedged into the chamber. One sideways dimension of the chamber is equal to the diameter of the capillaries and one end to end dimension varies from, at the top of the chamber, slightly greater than the sum of the diameters of the capillaries to, at the bottom of the chamber, slightly smaller than the sum of the diameters of the capillaries. The optical system utilizes optic fibres to deliver light to individual photodetectors, one for each capillary tube. A filter or wavelength division demultiplexer may be used for isolating fluorescence at particular bands.
Patent DK-0715747-T3 (DK)
Inventor: WAGNER ERNST-WERNER
IPC: G08B29/14
Filed: 1994-09-02
Granted: 1998-02-02
Abstract: PCT No. PCT/EP94/02917 Sec. 371 Date Feb. 28, 1996 Sec. 102(e) Date Feb. 28, 1996 PCT Filed Sep. 2, 1994 PCT Pub. No. WO95/06929 PCT Pub. Date Mar. 9, 1995There is indicated a method of generating smoke aerosols for proper planning and testing and for demonstration of the effectiveness of fire alarm systems, and pyrolysis apparatus for carrying out the method. In the method a test piece, for example, an electrical cable or the like, is heated over a specific period of time, according to a first alternative, along a predeterminable temperature curve, or, according to a second alternative, is held at a constant or a well-nigh constant temperature. By means of the method according to the invention it is possible to simulate a reproducible progress of a real electrical fire in a compressed period of time.
Patent DK-0688655-T3 (DK)
Inventor: DI SIMONE JOHN
IPC: B29C37/00
Filed: 1995-04-25
Granted: 1999-09-13
Abstract: A high speed, automatic device for removal of molded plastic articles from a multicavity injection mold including a method of minimizing molding machine cycle time.