Patent SG-11201807077R-A (SG)
Title: Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof
Inventor: ALEXANDER KATY
IPC: C07D495/04
Filed: 2017-03-01
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 8 September 2017 (08.09.2017) WIPO I PCT (10) International Publication Number WO 2017/151816 Al 1111111111111101110111111111110101111101110111111110111H01111111111111111110111111 (51) International Patent Classification: C07D 495/04 (2006.01) A61P 3/00 (2006.01) A61K 31/519 (2006.01) A61P 3/06 (2006.01) (21) International Application Number: PCT/US2017/020271 (22) International Filing Date: 1 March 2017 (01.03.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/302,755 2 March 2016 (02.03.2016) US 62/303,237 3 March 2016 (03.03.2016) US (71) Applicant: GILEAD APOLLO, LLC [US/US]; 333 Lakeside Drive, Foster City, California 94404 (US). (72) Inventors: ALEXANDER, Katy; c/o Gilead Apollo, LLC, 333 Lakeside Drive, Foster City, California 94404 (US). AMEDIO, John C., Jr.; c/o Gilead Apollo, LLC, 333 Lakeside Drive, Foster City, California 94404 (US). CALIMSIZ, Selcuk; c/o Gilead Apollo, LLC, 333 Lakeside Drive, Foster City, California 94404 (US). GEI- ER, Michael; c/o Gilead Apollo, LLC, 333 Lakeside Drive, Foster City, California 94404 (US). HARRIMAN, Geraldine C.; c/o Gilead Apollo, LLC, 333 Lakeside Drive, Foster City, California 94404 (US). HU, Sijun; c/o Gilead Apollo, LLC, 333 Lakeside Drive, Foster City, California 94404 (US). LAWSON, Jon P.; c/o Gilead Apollo, LLC, 333 Lakeside Drive, Foster City, California 94404 (US). MORRISON, Henry; c/o Gilead Apollo, LLC, 333 Lakeside Drive, Foster City, California 94404 (US). SABOURIN, Kyle; c/o Gilead Apollo, LLC, 333 Lakeside Drive, Foster City, California 94404 (US). SCOTT, Mark E.; c/o Gilead Apollo, LLC, 333 Lakeside Drive, Foster City, California 94404 (US). VARGHESE, Vimal; c/o Gilead Apollo, LLC, 333 Lakeside Drive, Foster City, California 94404 (US). VARIA, Kunal Arvind; c/o Gilead Apollo, LLC, 333 Lakeside Drive, Foster City, California 94404 (US). WANG, Xiaotin; c/o Gilead Apollo, LLC, 333 Lakeside Drive, Foster City, California 94404 (US). YANG, Xiaowei; c/o Gilead Apollo, LLC, 333 Lakeside Drive, Foster City, California 94404 (US). (74) Agents: TANNER, Lorna L. et al.; Sheppard Mullin Richter & Hampton LLP, 379 Lytton Avenue, Palo Alto, California 94301-1479 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Decl arations under Rule 4.17: as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Publ ished: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) W O 20 17 / 15 1816 Al (54) Title: SOLID FORMS OF A THIENOPYRIMIDINEDIONE ACC INHIBITOR AND METHODS FOR PRODUCTION THEREOF (57) : The present invention provides solid forms of compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, methods of producing the same, and methods of using the same in the treatment of ACC-mediated diseases.