Patent SG-11201910079R-A (SG)
Title: Methods for producing cells of the hematopoietic lineage using hydrogel encapsulation
Inventor: TARUNINA MARINA
IPC: C12N5/078
Filed: 2018-05-04
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 November 2018 (08.11.2018) WIPO I PCT mu °million ono oIII010001VIII 11111010IIlII (10) International Publication Number WO 2018/202900 Al (51) International Patent Classification: C12N 5/078 (2010.01) C12N 5/00 (2006.01) C12N 5/0786 (2010.01) (21) International Application Number: PCT/EP2018/061618 (22) International Filing Date: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (25) Filing Language: (26) Publication Language: (30) Priority Data: 1707143.2 04 May 2018 (04.05.2018) Published: English with international search report (Art. 21(3)) English 04 May 2017 (04.05.2017) GB (71) Applicant: PLASTICELL LIMITED [GB/GB]; Steve- nage Bioscience Catalyst, Gunnel Wood Road, Stevenage SG1 2FX (GB). (72) Inventors: TARUNINA, Marina; c/o Plasticell Ltd, Stevenage Bioscience Catalyst, Gunnel Wood Road, Steve- nage Hertfordshire SG1 2FX (GB). HUMBERT, Cedric; c/o Plasticell Ltd, Stevenage Bioscience Catalyst, Gunnel Wood Road, Stevenage Hertfordshire SG1 2FX (GB). ALI, Shahzad; c/o Plasticell Ltd, Stevenage Bioscience Cata- lyst, Gunnel Wood Road, Stevenage Hertfordshire SG1 2FX (GB). CHOO, Yen; c/o Plasticell Ltd, Stevenage Bio- science Catalyst, Gunnel Wood Road, Stevenage Hertford- shire SG1 2FX (GB). TSU TSHEN CHUANG, Aaron; c/o Plasticell Ltd, Stevenage Bioscience Catalyst, Gun- nel Wood Road, Stevenage Hertfordshire SG1 2FX (GB). SAW, Dennis; c/o Plasticell Ltd, Stevenage Bioscience Catalyst, Gunnel Wood Road, Stevenage Hertfordshire SG1 2FX (GB). Agent: MASCHIO, Antonio; Maschio & Soames IP Lim- ited, 30 Carlton Crescent, Southampton Hampshire S015 2EW (GB). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 00 (54) Title: METHODS FOR PRODUCING CELLS OF THE HEMATOPOIETIC LINEAGE USING HYDROGEL ENCAPSU- LATION (57) : A hydrogel capsule comprising a stem cell core that has been induced to differentiate into a hematopoietic lineage cell, 0 and methods for the production of hematopoietic lineage cells from stem cells encapsulated in a hydrogel.