baber/WOPTO huggingface dataset:
Patent CA-2369981-A1 (CA)
Title: Therapeutic compounds for inhibiting interleukin-12 signaling and methods for using same
Inventor: KLAUS STEPHEN J
IPC: A61P7/06
Filed: 2000-04-07
Abstract: Novel heterocyclic compounds having a six membered ring structure fused to a  five membered ring structure are found to be useful for the treatment and prevention of symptoms or manifestations associated with disorders affected by Interleukin-12 ("IL-12") intracellular signalling, such as, for example, Th1  cell-mediated disorders. The therapeutic compounds, pharmaceutically acceptable derivatives (e.g., resolved enantiomers, diastereomers, tautomers , salts and solvates thereof) or prodrugs thereof, have the general formula (I ). Each X, Y and Z are independently selected from a member of the group consisting of C(R3), N, N(R3) and S. Each R1, R2 and R3 is substituted or unsubstituted and is independently selected from a member of the group consisting of hydrogen, halo, oxo, C(1-20)alkyl, C(1-20)hydroxyalkyl, C(1- 20)thioalklyl, C(1-20)alkylamino, C(1-20)alkylaminoalkyl, C(1-20)aminoalkyl,  C(1-20)aminoalkoxyalkenyl, C(1-20)aminoalkoxyalkynyl, C(1-20)diaminoalkyl, C (1- 20)triaminoalkyl, C(1-20)tetraaminoalkyl, C(5-15)aminotrialkoxyamino, C(1- 20)alkylamido, C(1-20)alkylamidoalkyl, C(1-20)amidoalkyl, C(1- 20)acetamidoalkyl, C(1-20)alkenyl, C(1-20)alkynyl, C(3-8)alkoxyl, C(1- 11)alkoxyalkyl, and C(1-20)dialkoxyalkyl.
Patent CA-2370708-A1 (CA)
Inventor: DESCHAMPS MARGUERITE
IPC: A61P31/12
Filed: 2000-04-17
Abstract: The invention relates to a vaccine formulation comprising a Respiratory Syncytial Virus (RSV) antigen and an immunostimulatory CpG oligonucleotide, to methods of preparing the vaccine formulation and to its use in medicine. Further antigens may be included to provide new combination vaccines for administration to children, to adults and to the elderly.
Patent CA-2370762-A1 (CA)
Inventor: HOWALD ROBERT
IPC: H04H20/76
Filed: 2000-04-18
Abstract: A bidirectional dense wave division multiplexing (DWDM) cable television network architecture with frequency stacking system provides increased capacity in the reverse path. The combination of optical multiplexing, using dense wave division multiplexing, and RF multiplexing, using frequency stacking, significantly increases the efficiency of the return path in a bidirectional architecture. The ITU grid transmitters and the frequency stacking system may be located at the nodes, at the primary or secondary headends, or with the frequency stacking system at the node and the ITU grid transmitters at the primary/secondary headend.
Patent CA-2371927-A1 (CA)
Inventor: ANDERSON JUDY E
IPC: A61K31/216
Filed: 2000-03-10
Abstract: L'invention concerne des méthodes, des compositions pharmaceutiques et des trousses permettant de moduler l'activation du précurseur du muscle squelettique. Pour effectuer cette modulation, on utilise du monoxyde d'azote (NO), des donneurs de NO, des inhibiteurs d'activité du NO (inhibiteurs de NO) ou des régulateurs de production de NO, soit au niveau local, soit au niveau systémique. L'invention concerne également l'utilisation de NO, d'un donneur de NO, d'un inhibiteur de NO ou d'un régulateur de production de NO afin de moduler les effets des stéroïdes hormonaux sur le muscle squelettique. L'invention concerne également une méthode permettant d'identifier un composé qui provoque un changement de l'état d'activation des précurseurs du muscle. L'invention apporte un certain nombre d'avantages évidents. En permettant de manipuler directement les précurseurs du muscle squelettique, l'invention permet d'élaborer des traitements spécifiques afin de régénérer et de réparer le muscle.
Patent CA-2374568-A1 (CA)
Title: Apparatus and method for ultrasonically and electromagnetically treating tissue
Inventor: TALISH ROGER J
IPC: A61N2/00
Filed: 2000-05-18
Abstract: The invention relates to apparatus and method for ultrasonically and electromagnetically treating tissue to treat, for example, traumatized tissu e or a bone injury. The apparatus includes at least one ultrasonic transducer assembly (26) and at least one electromagnetic coil assembly (28) configured  to cooperate with a placement module for placement in proximity to the treatment area. The apparatus also utilizes a portable main operating unit constructed to fit within a pouch or carrying case worn by the patient. In operation, at least one ultrasonic transducer and at least one elecromagneti c coil are activated by transmitting control signals to the placement module from the main operating unit. The activation of the at least one ultrasonic transducer causes ultrasonic waves to be propagated toward the treatment are a which are modulated by electrostatic and magnetic forces generated by the at  least one electromagnetic coil. The activation of the at least one ultrasoni c transducer and the at least one electromagnetic coil may be performed at the  same time or at different times for varying periods.
Patent CA-2375453-A1 (CA)
Title: Bidirectional lateral flow test strip and method
Inventor: SIERRA GEORGE H
IPC: G01N33/558
Filed: 1999-11-17
Abstract: A bidirectional flow test strip adapted to receive a sample and detect an analyte therein is provided. The test strip comprises a sample addition zone to which a sample may be added; an absorbent zone proximal to the sample addition zone; one or more test zones distal to the sample addition zone, at least one of the test zones including a first analyte binding agent immobilized therein which is capable of binding to the analyte to be detected; and a terminal sample flow zone distal to the one or more test zones, the absorbent zone being positioned relative to the sample addition zone and having an absorption capacity relative to the other zones of the test strip such that a distal diffusion front of a sample added to the sample addition zone diffuses from the sample addition zone to a distal diffusion point within the terminal sample flow zone and then reverses direction and diffuses proximal relative to the one or more test zones.
Patent CA-2376342-A1 (CA)
Inventor: CHIU ALBERT HERMAN
IPC: F16K11/076
Filed: 2002-03-13
Abstract: A faucet having a plurality of water discharges includes a housing, diverter valve within the housing, a stream discharge on the housing, an upward fountain discharge on the housing, and an upward spray discharge on the housing. The diverter valve connects the mixed water conduit to the water discharges. A handle external to the housing engages the diverter valve to selectively define a flow path between the mixed water supply and the selected water discharge.
Patent CA-2379510-A1 (CA)
Title: Selective extraction using mixed solvent system
Inventor: KENT CHRISTOPHER JEFFREY STILL
IPC: C10M177/00
Filed: 2000-07-21
Abstract: A method for concentrating the amount of alkylated mono-aromatics in a lubricating oil feedstock useful as a feedstock for sulfonation. The method comprises extracting a feedstock rich in aromatics with a solvent selected from NMP, phenol and furfural, said feedstock containing sufficient water to provide a raffinate having a target VI between about 86 and 97 under extraction conditions of treat and temperature selected to achieve the target VI. The raffinate is then hydrofined and solvent dewaxed.
Patent CA-2380067-A1 (CA)
Inventor: SHIRANE KORO
IPC: H01L51/50
Filed: 2001-05-21
Abstract: The invention relates to a light-emitting material and organic electroluminescent (EL) device having high emitting efficiency, in which two  organic compounds that contribute to the light emission are used. These two organic compounds have a relationship among energy levels in the excited state, such that an energy transfer takes place from the excited triplet sta te of one compound to the excited triplet state of the other compound. The organic EL device and light-emitting material of the invention have high emitting efficiency, high luminance and durability, can surpass the marginal  value of 25 % in the internal quantum efficiency conventionally acknowledged  for the light-emitting materials used in organic EL devices, and can be applicable to all emission colors considered necessary for a display.</SDOAB >
Patent CA-2380085-A1 (CA)
Inventor: LORENZI MARC PAUL
IPC: A61K8/00
Filed: 2000-08-01
Abstract: The present invention relates to a substantially dry, disposable personal care article comprising: a) a water insoluble substrate comprising: 1) a nonwoven first layer; 2) a second layer which is disposed adjacent to said first layer; b) a cleansing component disposed adjacent to said first and second layers, wherein said component comprises: 1) from about 10% to about 1000%, by weight of the water insoluble substrate, of a lathering surfactant; wherein said article exhibits the following surfactant dissolution related physical properties individually or in combination with one another.  The properties exhibited include a Dynamic Surface Tension Value of less than about 54 dynes/cm2 in beaker 1 and greater than about 60 dynes/cm2 in beaker 5, a Flash Lather Volume of from about 500 ml to about 3500 ml, a Latherability of from about 500 ml to about 7000 ml, a Surfactant Dissolution Extent of greater than about 30 ml in beaker 1, greater than about 30 ml in beaker 4 and less than about 90 ml in beaker 8, and a Lather Dissipation Time of from about 5 sec to about 62 sec. The present invention further relates to articles which further comprise a therapeutic benefit component. Each of the present articles has been found to be particularly useful for personal cleansing applications, namely for the skin and hair.
Patent CA-2380143-A1 (CA)
Inventor: FUJITANI NAOHIRO
IPC: G06Q10/10
Filed: 2002-04-03
Abstract: It is an object of the present invention to provide a server site for supporting the course of producing one printing material typically with the cooperation of a plurality of parties of, for example, a publishing company, a printing company, a plate making company, a designer and the like. There are provided a designation reception section receiving a designation of a job representing one work consisting of a series of steps for producing one printing material, designation of a workflow representing procedures for executing the job and input of information on a client executing one job together with a predetermined customer, from a terminal of the predetermined customer among a plurality of terminals connected through a communication line; a security management section 147 managing information on the customer and the information on the client; a job management server 140 managing a progress status of the job received by the definition reception section for each job; a work space server 150 managing a substantial file storing data available as the printing material or data available as a part of the printing material relating to the job received by the definition reception section for each job; and an asset content server 160 managing the substantial file for each customer.
Patent CA-2382225-A1 (CA)
Inventor: CHIA CHEO K
IPC: A44C17/02
Filed: 2000-06-30
Abstract: A decorative jewelry item comprises a base member with a hollow interior and a decorative top, a cap brought down over the decorative top, and a fastener arrangement for fixing the cap to the base member after the cap is brought into contact with the decorative top. The cap has an opening therein through which the decorative top of the base member can be observed. All exposed surfaces of the base member and cap may have surface finishing features and/or graphic representations or designs to make the jewelry item more attractive. In an alternative construction, a decorative insert is inserted, through an opening in the top of a hollow base member, and is fixed within the base member with the insert below the base member top and viewable through the top opening.
Patent CA-2383124-A1 (CA)
Title: Method of making a spirally-wound tube
Inventor: WARCHOLINSKI MAREK
IPC: B29K101/12
Filed: 2000-10-27
Abstract: This invention concerns a method and an apparatus for making a spirally-wound tube from a hollow thermoplastic profile (1) having a substantially rectangular cross-section, which method comprises the steps of: winding the thermoplastic profile (1) around a drum (2) and joining adjacent loops together by welding, and smoothing the outer weld joint (13) by means of extra heat and a smoothing body resting against the weld joint (13). The invention is characterized in that the thermoplastic profile (1), when fed to the drum (2), comes onto a stationary first section (3) comprising spaced sliding means (5) arranged along the periphery, on which section welding is performed, after which an inner weld joint (11) thus formed is arranged to run along a spiral groove (14) running around the stationary first section (3), whereby the inner weld joint (11), as well as the outer weld joint (13), are treated by using extra heat and a stationary smoothing body (10) resting against it, and that the tube, once both of the welded surfaces (11, 13) have been smoothed, is transferred to a rotary driven drum section (4) causing the tube to rotate and generating the winding motion of the thermoplastic profile (1).
Patent CA-2384636-A1 (CA)
Inventor: AMRANI HASSAN
IPC: G01N21/64
Filed: 2000-10-05
Abstract: A normalisation apparatus arranged to normalise a first signal in relation t o a second signal, the apparatus comprising a comparator arranged to discriminate the first signal, characterised in that the first signal is digital and the normalisation apparatus further comprises means for spreadin g th4e first signal over a predetermined energy distribution, and means for automatically adjusting a discrimination level of the comparator in response  to a property of the second signal such that a proportion of the distributed  signal is discarded by the comparator.
Patent CA-2388013-A1 (CA)
Inventor: TARUI HISAKI
IPC: H01M50/103
Filed: 2000-10-20
Abstract: An electrode for a lithium secondary cell characterized in that an active material thin film absorbing/desorbing lithium such as a microcrystalline silicon thin film or an amorphous silicon thin film is deposited on both sides of a platelike current collector.
Patent CA-2388403-A1 (CA)
Title: Exhaust passage structure in outboard engine system
Inventor: YOSHIDA HIROYUKI
IPC: F01N13/18
Filed: 2000-09-22
Abstract: A split face 481 of an exhaust passage-defining member 48 is coupled to a split face 41 2 provided at a rear portion of an oil case 41 interposed between an engine block 11 and an extension case 42. A main exhaust gas expansion chamber e3 and a subsidiary exhaust gas expansion chamber e7 are defined between the exhaust passage-defining member 48 and the oil case 41, so that an exhaust gas supplied from a first exhaust passage e1 in the oil case 41 is discharged into a second exhaust passage e5 in the oil case 41 via the main exhaust gas expansion chamber e3. A portion of the exhaust gas in the main exhaust gas expansion chamber e3 is passed through a communication bore e6 and the subsidiary exhaust gas expansion chamber e7 and discharged from an exhaust outlet e8 into the air. Thus, the exhaust gas expansion chambers e3 and e7 can be exposed for the maintenance only by separating the exhaust passage-defining member 48 from the oil case 41 without disassembling of the oil case 41, leading to a remarkable enhancement in maintenance property.
Patent CA-2388864-A1 (CA)
Title: Ortho ester lipids
Inventor: ZHU JI
IPC: A61P25/36
Filed: 2000-10-05
Abstract: The present invention provides ortho ester lipids and their derivatives that, upon certain pH conditions, undergo hydrolysis with concomitant or subsequent headgroup cleavage. These ortho ester lipids can advantageously be formulated into liposomes. The liposome formulations are useful in nucleic acid transfection and entrapment/delivery of conventional small molecules and therapeutic agents. Moreover, the liposomes comprising compounds of the present invention are useful as drug delivery vehicles.
Patent CA-2394842-A1 (CA)
Title: Tongue cleaning device
Inventor: CHAN JOHN GEOFFREY
IPC: A61B17/24
Filed: 1999-12-22
Abstract: Disclosed is a tongue cleaning device comprising a body having a handle and at one end thereof a head provided with a plurality of convex extrusions on at least one side of the head. Also disclosed is a tongue cleaning device comprised of a body having a handle and at one end thereof a head provided with at least one raised ridge. Also disclosed is a device wherein the head is further provided with tooth-cleaning bristles on the side of the head that is opposite to the side that is provided with the convex extrusions or with the at least one raised ridge. Still further disclosed is a tongue cleaning device comprised of a body having a handle and at one end thereof a head provided with tooth-cleaning bristles extending from the head on one side of the head, the tooth cleaning bristles further extending through the head to a height of up to about 7 mm on the opposite side of the head to form extension bristles for tongue cleaning.
Patent CA-2394851-A1 (CA)
Inventor: SPINELLI VITO A
IPC: E05F15/20
Filed: 2000-12-07
Abstract: An automatic door assembly operates with a video device which transmits an internal video data signal comprising information of a doorway approach area  to a detection system to determine whether a person or object has entered th e approach area and if so transmits a door opening signal to a door controller . The video data signal is further processed for displaying images of said are a for visual surveillance by security personnel.
Patent CA-2396005-A1 (CA)
Title: Gambogic acid, analogs and derivatives as activators of caspases and inducers of apoptosis
Inventor: TSENG BEN
IPC: C07D493/20
Filed: 2000-02-01
Abstract: The present invention is directed to gambogic acid, analogs and derivatives thereof, represented by general Formulae (I-III) wherein R1-R5 are defined herein. The present invention also relates to the discovery that compounds having Formulae (I-III) are activators of caspases and inducers of apoptosis . Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditio ns in which uncontrolled cell growth and spread of abnormal cells occurs.</SDOA B>
Patent CA-2396319-A1 (CA)
Title: Ophthalmic compositions for treating ocular hypertension
Inventor: MCMANUS OWEN B
IPC: A61P25/28
Filed: 2001-01-17
Abstract: This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraocular pressure in the eye of a patient. This inventi on also relates to the use of such compounds to provide a neuroprotective effec t to the eye of mammalian species, particularly humans.
Patent CA-2396735-A1 (CA)
Title: Transformateur elevateur de puissance
Inventor: MARCOUX SYLVERE
IPC: H01F30/06
Filed: 2002-08-20
Abstract: Le transformateur de puissance est un appareil qui produit plus d'énergie électrique ou'il n'en consomme. (input < output)
Patent CA-2398031-A1 (CA)
Title: Collection storage system
Inventor: JAMESON KEVIN W
IPC: G06F17/30
Filed: 2002-08-27
Abstract: A Collection Storage System helps software developers to manage the storage and evolution of collections of computer files, by performing collection storage operation s on collections and collection views. Collections are sets of computer files that can be manipulated as a set, rather than as individual files. Collection views are groups of related collection references that can be processed by human workers using a single operation on a single set of collection references, rather than by performing a series of individual operations on individual collections. In operation, a Collection Storage System receives collection storage operation requests from request originators. It performs the operations, often in the presence of collection information and collection view information that describes the target collections, views , and operations in detail. Finally, it returns operation results to the request originators. Collection Storage Systems improve human productivity by enabling people to perform collection-aware configuration management operations on collections and collection views, using advanced collection storage operations that were not previously known to the art.
Patent CA-2398808-A1 (CA)
Inventor: LOVAS SANDOR
IPC: G01N33/68
Filed: 2001-01-19
Abstract: A method for identifying a compound that has a biocidal effect against a selected organism involves screening from among known or unknown peptide or non-peptide molecules, a test molecule that binds selectively to a target sequence of a multi-helical lid of a heat shock protein of the organism. The binding of the test compound inhibits the protein folding activity of the protein. A specific embodiment of such a method is useful for identifying or designing a pharmaceutical or veterinary biocidal or antibiotic compound, preferably a pathogen and/or strain-specific compound. For this purpose, the compound does not bind to a heat shock protein that is homologous to the mammalian subject to be treated with the compound. Screening methods can encompass direct binding or competitive assays. Molecules or compounds identified by these methods are employed as biocides for pharmaceutical, veterinary, pesticide, insecticide and rodenticide uses, among others.
Patent CA-2398983-A1 (CA)
Inventor: ESTRADA GARCIA MARIO PABLO
IPC: A61K38/08
Filed: 2001-12-17
Abstract: L'invention concerne la médecine humaine et, d'une manière plus spécifique, une combinaison pharmaceutique du facteur de croissance de l'épiderme (EGF) et d'un peptide mimétique du facteur de libération de l'hormone de croissance (GHRP), laquelle est utile pour la prévention et/ou la réparation des dommages tissulaires provoqués par un défaut d'irrigation sanguine d'un organe déterminé en raison de différents états pathologiques. Cette combinaison peut être utilisée dans une même composition pharmaceutique ou appliquée à un même individu séparément, comme partie d'un traitement unique qui favorise la vitalité cellulaire dans des organes lorsque ces derniers sont soumis à une privation partielle ou totale de l'apport de sang oxygéné pendant une certaine période. Cette combinaison, qui atténue également la formation d'espèces et de métabolites toxiques dans lesdits organes, est particulièrement utile pour des tissus soumis à des périodes prolongées d'ischémie. Cette combinaison pharmaceutique peut en outre être appliquée à des fins prophylactiques à des patients présentant des états qui peuvent occasionner, sur des organes, un dysfonctionnement ou des dommages multiples ayant des origines diverses, par exemple des brûlures, des polytraumatismes, le syndrome de détresse respiratoire, l'hypoxie chez les nouveau-nés, le choc hypovolémique, l'entérocolite nécrosante. Cette combinaison pharmaceutique peut également être appliquée à des patients soumis à d'importantes interventions chirurgicales.
Patent CA-2400397-A1 (CA)
Title: Intraocular lens manufacturing process
Inventor: SARBADHIKARI KAMAL K
IPC: B29D11/02
Filed: 2001-02-15
Abstract: A method of cast molding an intraocular implant from two or more dissimilar materials using disposable molds. The subject cast molding method is particularly useful in the production of intraocular lenses manufactured from dissimilar materials.  It is desirable to produce introacular lenses from dissimilar materials in order to optimize the optical characteristics of the intraocular lens optic portion and to optimize stability and flexibility characteristics of the intraocular lens haptic elements.
Patent CA-2401229-A1 (CA)
Title: Aryl fused azapolycyclic compounds
Inventor: BROOKS PAIGE ROANNE PALMER
IPC: A61P25/16
Filed: 2001-02-08
Abstract: This invention is directed to compounds of formula (I) and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such compounds; and methods of using such compounds in the treatment of neurological and psychological disorders.