baber/WOPTO huggingface dataset:
Patent EA-010234-B1 (EA)
Title: Tetrahydroisoquinoline sulfonamide derivatives, the preparation thereof, and the use of the same in therapeutics
Inventor: DIAZ MARTIN JUAN ANTONIO
IPC: C07D217/06
Filed: 2005-05-24
Abstract: The invention relates to a compound of formula (I)wherein n can represent a value between 1 and 6; -(C)n- represents a C-alkylidene group, optionally substituted by between 1 and 4 substituents; R1 represents a hydrogen atom, or a Calkyl group; R2 represents a hydrogen atom, a Calkyl or C-cycloalkyl group optionally substituted by between 1 and 4 substituents; and B represents NR3R4, R3 and R4 independently representing a Calkyl group or a hydrogen atom, or together representing a C-alkylidene group, a C-alkenylidene group, a C-alkylidene-O-C-alkylidene group, or a C-alkylidene-N(R5)-Calkylidene group wherein R5 represents a hydrogen atom, or a C-alkyl or Calkylcarbonyl group, said C-alkyl and Calkylcarbonyl groups being substitutable, or an aminocycle which is linked by a carbon to the group -NR1-(C)n-, such as aziridine, azetidine, pyrrolidine, piperidine or morpholine, the groups R3, R4, the aminocycle, and the nitrogen atom being optionally substituted. The invention can be applied to therapeutics.
Patent EA-011540-B1 (EA)
Title: Method for determining human's (sportsman) motion activity and apparatus therefor
Inventor: MORARU EUGEN
IPC: A61B5/11
Filed: 2007-07-23
Abstract: A method for determining human's motion activity, more particular certain body part (arm or leg) characterized in that one two-coordinate autonomous microcontrolling device is arranged on the human's body, the device comprises two sensors (1,2) of linear displacements (accelerometers), each of them is directed to one of two mutually perpendicular axes (XY), output signals of which are multiplexed, digitized, processed and recorded in RAM, and after implementing the task can be read via USB to an outer PC, e.g. for storing in the database.
Patent EA-014530-B1 (EA)
Title: Process for the preparation of pharmaceutical intermediate
Inventor: TRINKA PETER
IPC: C07D295/088
Filed: 2006-12-08
Abstract: The present invention relates to a process for the preparation of {2-[4-(α-phenyl-n-chlorobenzyl)-piperazin-1-yl]-ethoxy}-acetic acid-N,N-dimethylamide of the Formula (I) and enantiomers thereof. The compound of the Formula (I) or enantiomers thereof are important pharmaceutical intermediates suitable for direct transformation into non-sedating antihistamine type pharmaceutical active ingredients cetirizine and levocetirizine.
Patent EA-015563-B1 (EA)
Title: Small internally segmented interfering rna
Inventor: WENGEL JESPER
IPC: A61K31/7088
Filed: 2007-03-23
Abstract: The present invention is directed to pharmaceutical and therapeutic compositions which comprise RNA complexes comprising an antisense strand and a discontinued passenger strand capable of regulating gene expression. The use of a discontinued passenger strand reduces off target effects of the RNA complexes and also has other advantages.
Patent EA-014128-B1 (EA)
Title: Applicator wheel for filling cavities with metered amounts of particulate material
Inventor: SMITH BARRY S
IPC: B65B1/36
Filed: 2007-05-31
Abstract: A machine (10) and process function to fill cavities (16) with metered amounts of particulate material is disclosed. An applicator wheel 18 includes a series of equally spaced apart peripheral pockets (24) each having a perforated bottom wall (32), and a vacuum manifold (34) inside the wheel includes a vacuum chamber 38 for supplying vacuum to the perforated bottom walls of the pockets as the wheel rotates. Particulate material (20) from a filling chamber (26) of such material outside the wheel is withdrawn into the pockets by the vacuum chamber. A downstream vacuum relief (48) on the vacuum manifold functions to discharge particulate material from the pockets into the cavities at a predetermined discharge location on the wheel. Adjustment structure (52, 54) is connected to rotatably adjust the position of the vacuum manifold within the applicator wheel to thereby advance or retard the discharge location depending upon the speed of the machine.
Patent EA-018220-B1 (EA)
Title: Prolyl hydroxylase inhibitors
Inventor: DUFFY KEVIN J
IPC: A61K31/47
Filed: 2007-06-22
Abstract: The invention described herein relates to a compound N-[(1,3-dicyclohexyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)carbonyl]glycine or a pharmaceutically acceptable salt thereof, which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
Patent EA-021758-B1 (EA)
Title: Method for treating alzheimer's disease
Inventor: ALBRIGHT CHARLES F
IPC: A61P27/00
Filed: 2009-04-24
Abstract: The invention relates to a method for treating Alzheimer's disease. The method comprises intravenous administration a therapeutically-effective of epothilone D to a patient in need thereof, wherein the cumulative monthly dose of epothilone D is between 0.1-3 mg/m. The method provides the epothilone D good brain penetration, long brain half-life, and a high selective retention in brain that provides effective therapies in treating Alzheimer's disease without causing drug-induced side effects that would require that use of the epothilone D treatment be discontinued.
Patent EA-019342-B1 (EA)
Title: Novel polymorphic forms of 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)benzonitrile hydrochloride salt and processes of manufacturing them
Inventor: BECKER AXEL
IPC: A61K31/506
Filed: 2009-12-04
Abstract: The present invention relates to hydrochloride solvates of 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)pyrimidin-2-yl]benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)benzonitrile and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer.
Patent EA-029939-B1 (EA)
Title: Human binding molecules capable of neutralizing influenza virus h3n2 and uses thereof
Inventor: THROSBY MARK
IPC: C07K16/10
Filed: 2010-05-06
Abstract: The present invention relates to binding molecules, such as human monoclonal antibodies, that bind to influenza virus comprising HA of the H3 subtype, such as H3N2, and have a broad neutralizing activity against such influenza virus. The present invention also relates to nucleic acid molecules encoding the antibodies, their sequences, compositions comprising said antibodies and methods of identifying or producing such antibodies. Said antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H3N2 subtype infection. In a preferred embodiment, said antibodies provide cross-subtype protection against infections caused by viruses of various subtypes, such that infections with H3, H7, and/or H10-based influenza subtypes can be prevented and/or treated.
Patent EA-020429-B1 (EA)
Title: Process for the preparation of esomeprazole
Inventor: KOTAR-JORDAN BERTA
IPC: C07D401/12
Filed: 2009-12-22
Abstract: The invention relates to an improved process for preparation of esomeprazole or salts thereof by optical resolution of omeprazole with binol (1,1'-bi-2-naphthol).
Patent EA-022933-B1 (EA)
Title: Thioacetate compounds, compositions based thereon and methods of use
Inventor: OUK SAMEDY
IPC: A61K31/444
Filed: 2011-06-15
Abstract: Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid.
Patent EA-026930-B1 (EA)
Title: Method for production of dioscinin from puncture vine
Inventor: Iskenderov Gaibverdi Bashir ogly
IPC: A61K31/335
Filed: 2014-12-25
Abstract: The invention is related to pharmaceutical preparations production technology and to a method for producing dioscinin from puncture vine, dioscinin being the main active ingredient of polysponin, a medicinal product that is widely used for treatment and prophylaxis of atherosclerosis. The essence of the invention consists in development of a new process for dioscinin production from puncture vine comprising use of puncture vine Tribulus terrestris as raw material, grinding of dried above-ground parts, degreasing with petroleum ether, removal of less polar glycosides by successive extraction with 95% ethanol, successive extraction of polar glycosides with 50% ethanol, evaporation of ethanol, filtration of water residue, extraction of glycosides from water solution with n-butanol (butanol), washing of n-butanol extract with 10% ammonia solution, complete distilling off of butanol, dilution of the residue with water, addition of acetone, separation of precipitate, boiling of water-acetone solution to dryness, drying, obtaining the target product in the form of off-white, slightly yellowish powder.
Patent EA-027954-B1 (EA)
Title: Process and apparatus for generating or recovering hydrochloric acid from metal salt solutions
Inventor: BLUNN ADAM JUSTIN
IPC: C01B7/03
Filed: 2013-06-26
Abstract: The present invention relates to an electrochemical process for generating or recovering hydrochloric acid from metal salt solutions such as acidic metal salt solutions and saline solutions. The process is useful for treating acidic salt solutions that are waste products from mineral processing or other industrial processes such as metal finishing, water softening, water treatment, reverse osmosis, electrodialysis, coal seam gas extraction, shale gas extraction and shale oil extraction, to generate high purity hydrochloric acid, metal salts and recycled water that may be re-used in the industrial process. An apparatus for performing the electrochemical process is also described.
Patent EA-032975-B1 (EA)
Title: Pharmaceutical composition comprising a cyclic peptide of formula x-gqretpegaeakpwy-xand use for extracorporeal lung treatment
Inventor: FISCHER HENDRIK
IPC: A61P11/00
Filed: 2014-04-18
Abstract: A method of conditioning/improving lung functions extracorporeally by treatment of a lung ex vivo with a cyclized compound of the amino acid sequence of formula I: X-GQRETPEGAEAKPWY-X, wherein Xcomprises an amino acid (sequence) with 1 to 4 members, comprising natural or unnatural amino acids, and Xcomprises one amino acid, selected from natural amino acids; and a pharmaceutical composition, comprising a peptide of formula I as defined in any one of claims 1 to 7, in a form, which is appropriate for spraying to obtain an aerosol for inhalation, or which is appropriate for the preparation of a spray to obtain an aerosol upon spraying, which is appropriate for inhalation.
Patent EA-032186-B1 (EA)
Title: Seismic adaptive focusing
Inventor: ETGEN JOHN THEODORE
IPC: G01V1/30
Filed: 2015-04-02
Abstract: A method for use in seismic exploration comprises accessing a set of seismic data representative of a subterranean geological formation and a subsurface attribute model of the subterranean geological formation; performing a wavefield extrapolation on the seismic data in the subsurface attribute model; applying the time-shift extended imaging condition to the extrapolated wavefields; forming shot-indexed, time shift gathers for each image pixel of the subsurface attribute model from the conditioned extrapolated wavefields; adaptively focusing the gathers; and stacking the adaptively focused gathers; and imaging the subterranean geological formation from the stacked, adaptively focused gathers. The method may, in some aspects, be realized by computing apparatuses programmed to perform the method or as a set of instructions encoded on a non-transitory program storage medium that, when executed by a computing apparatus, perform the method.
Patent EA-037691-B1 (EA)
Title: Device positionable in the uterine cavity
Inventor: BAR-AM ILAN
IPC: A61F6/14
Filed: 2014-12-11
Abstract: An intrauterine device and method of delivering and using same are provided. The intrauterine device includes a wire having a portion capable of forming a three dimensional (3D) structure. The 3D structure is elastically deformable to a partially collapsed configuration via a crush force larger than a force applied thereto by a relaxed uterine cavity. The three dimensional structure is also capable of elastically contracting and expanding in response to contraction and expansion of the uterine cavity.
Patent EA-034849-B1 (EA)
Title: Group acknowledgement/negative acknowledgement and triggering gack/channel state information
Inventor: DABEER ONKAR JAYANT
IPC: H04L1/16
Filed: 2016-01-21
Abstract: According to the present disclosure, CSI and/or a plurality of ACKs related to a group of DL data transmissions may be buffered at the UE as a GACK until a DCI trigger is received from the eNB. Once the trigger is received, the UE may transmit the CSI and/or GACK to the eNB. In this way HARQ feedback and/or CSI may be reliably communicated while reducing payload. In an aspect of the disclosure, a method, a computer-readable medium, and an apparatus are provided. The apparatus send, to a UE, data transmissions associated with a first plurality of downlink subframes. In an aspect, the apparatus increments a counter for each data transmission sent to the UE. In a further aspect, the apparatus transmits, to the UE, a first trigger for a first GACK when a counter is greater than or equal to a threshold.
Patent EA-034359-B1 (EA)
Title: Electrode for electrolytic processes
Inventor: CALDERARA ALICE
IPC: C25B11/04
Filed: 2016-06-22
Abstract: Provided is an electrode suitable for oxygen evolution in electrolytic processes comprising a valve metal substrate provided with a coating comprising a catalytic layer containing platinum group metals and outer and inner protective layers, wherein said catalytic layer is interposed between the outer and inner protective layers, wherein said protective layers consist of a mixture of oxides having a weight composition referred to the metals containing 89-97% of tin, 2-10% of at least one doping element selected from the group consisting of bismuth, antimony and tantalum and 1-9% of ruthenium. The electrode is useful in processes of non-ferrous metal electrowinning.
Patent EA-034323-B1 (EA)
Title: N-(1,3,4-oxadiazol-2-yl)aryl carboxamide derivatives with herbicidal action
Inventor: KOEHN ARNIM
IPC: C07D271/113
Filed: 2016-06-29
Abstract: The invention relates to N-(1,3,4-oxadiazol-2-yl)aryl carboxamide derivatives of the general formula (I)as herbicides. In said formula (I), W is CY; X and Z are each independently, accordingly, halogen, (C-C)alkyl, trifluoromethyl; Y is S(O)R; V is hydrogen; Ris (C-C)alkyl; n is 0, 1 or 2; A is an A1, A2 or A3 radicalR is (C-C)alkyl-OC(O)OR; Ris (C-C)alkyl; Ris (C-C)alkyl or (C-C)cycloalkyl.
Patent EA-038265-B1 (EA)
Title: Method and system for detecting fraudulent transactions
Inventor: OBOLENSKY IVAN ALEXANDROVICH
IPC: G06Q20/00
Filed: 2018-12-21
Abstract: The invention relates to data processing methods using computer systems, in particular to fraudulent transactions search system and method. The technical result consists in increase of processing speed of multiple transactions to identify details of fraudulent transaction nodes. The claimed result is achieved by a computer-based method of search for fraudulent transactions by obtaining a transaction data stream where at least a part of data characterizes fraudulent transactions; forming a graph model of the transaction movement based on the obtained stream; determining at least two graph nodes related to one fraudulent transaction; determining a list of neighborhoods for each of said graph nodes; determining a set of intersections of said list of neighborhoods for each of said nodes; determining graph nodes included in at least one intersection of said list of neighborhoods of two nodes; building the shortest route based on the minimum number of nodes and edges between said nodes taking into account graph nodes.
Patent EA-039516-B1 (EA)
Title: Manicure method
Inventor: KREMINSKAYA IRINA YURIEVNA
IPC: A45D29/00
Filed: 2021-04-26
Abstract: This invention relates to the field of nail service in the consumer service field. A manicure method includes processing of the nail plate, removing of the keratinous layer from periungual walls and of periungual skin in the cuticle region. To remove the keratinous layer from periungual area, in the zone of cuticle, a tapered cutter is used, with a flat base, with diameter equal to 2.7-3.2 mm, and with an abrasive lateral surface, its inclination angle to the flat base being 40-50°. It is applied, at a rotation speed of 10,000-15,000 rpm, with its lateral abrasive surface to the cuticle to the entire depth and held in each contact point for 0.5-0.8 s. Periungual area is processed staring from the right sinus from the client's side, then using back-and-forth swinging motion, the cutter is displaced clockwise towards the left sinus, to the next contact point, and the cutter base is held in parallel to the nail at the distance h equal to 0.9-0.15 mm from it. The technical objective is reduction of probability of traumatizing the eponychium and the speed of pterygium growth, with simultaneous reduction in labor content of this process and reduction in the time required for the procedure.
Patent ES-2195677-B1 (ES)
Title: Molde conservador de gasometrias.
Inventor: MOLINA PEREZ CONCEPCION
IPC: A61J1/16
Filed: 2000-03-17
Granted: 2004-11-16
Abstract: El molde conservador de gasometrías (a) es un recipiente preparado para albergar de manera ordenada jeringas de gasometría (b), debidamente selladas por su correspondiente tapón de jeringuilla (g), que se empapa en agua y posteriormente se somete a congelación constituyendo una fuente de frío que garantiza el mantenimiento de la muestra sanguínea, desde el momento de la extracción hasta el momento del análisis, eliminando en lo posible dos de los errores reconocidos como habituales en la práctica diaria hospitalaria: 1- Conservación a temperatura ambiente de la muestra sanguínea. 2- No mantener la muestra en hielo picado si el tiempo que transcurre entre extracción y análisis excede de diez minutos. Consta de los siguientes elementos: recipiente (c) fuente de frío (d) matrices de la fuente de frío (e) cilindros protectores (f).
Patent ES-2190303-B1 (ES)
Title: Procedimiento flexible de produccion de bases de aceites y destilados para una conversion-hidroisomerizacion sobre un catalizador ligeramente disperso seguida de un desparafinado catalitico.
Inventor: BENAZZI ERIC
IPC: B01J23/42
Filed: 2000-04-27
Granted: 2005-02-16
Abstract: Procedimiento flexible de producción de bases de aceites y destilados para una conversión hidroisomerización sobre un catalizador ligeramente disperso seguida de un desparafinado catalítico. La invención se refiere a un procedimiento, mejorado, de fabricación de aceites de base de muy alta calidad y de producción simultánea de destilados medios de alta calidad, que comprende las etapas sucesivas de hidroisomerización y de desparafinado catalítico. La hidroisomerización se desarrolla en presencia de un catalizador que contiene al menos un metal noble depositado sobre un soporte ácido amorfo, siendo la dispersión en metal de 20-100%. Preferentemente, el soporte es una sílice- alúmina amorfa. El desparafinado catalítico se desarrolla en presencia de un catalizador que contiene al menos un elemento hidro-deshidrogenante (grupo VII) y al menos un tamiz molecular (zeolita preferida). Preferentemente, el tamiz es elegido entre la zeolita NU-10, EU-1, EU-13 y ferrierita.
Patent ES-2222795-B1 (ES)
Title: Metodo de analisis de residuos de plaguicidas en aceites vegetales.
Inventor: VILLEN ALTAMIRANO JESUS
IPC: B01D15/08
Filed: 2003-03-28
Granted: 2005-12-01
Abstract: El objeto de la invención es un método de análisis de residuos de plaguicidas en aceites vegetales totalmente automático. El método utiliza el dispositivo de interfase para el acoplamiento directo de cromatografía de líquidos y cromatografía de gases, denominado en la literatura científica interfase TOTAD (Through Oven Transfer Adsorption Desorption). El método no requiere etapa previa de extracción-concentración. La muestra, previamente filtrada, es inyectada directamente en el cromatógrafo de líquidos. Los plaguicidas son separados en cromatografía de líquidos en fase inversa de los triglicéridos del aceite, y la fracción que contiene los plaguicidas es transferida automáticamente al cromatógrafo de gases, donde tiene lugar el análisis. El empleo de fase inversa en cromatografía de líquidos elimina los problemas del empleo de fase normal (deterioro del sistema cromatográfico). El método de análisis permite realizar tanto el análisis multidimensional de distintos plaguicidas como el análisis individual de cada uno de ellos.
Patent ES-2254024-B1 (ES)
Title: Llave ergonomica para cerraduras.
Inventor: RECONDO GARAYALDE PEDRO
IPC: E05B19/00
Filed: 2004-11-22
Granted: 2007-08-01
Abstract: Llave ergonómica para cerraduras, donde la llave consta de una pala (1), que incorpora los medios de combinación que operan en conjunción con otros existentes en la cerradura, y un mango o asidero accionador que está formado por un núcleo (2) que, por lo general, conlleva colateralmente un par de aletas (3) configurando en conjunto una cabeza (4) de asido para su manipulación en la que está practicado un orificio para su anillado en un llavero, tomando como respectivas referencias delantera y trasera la punta de la pala (1), y la cabeza (4), que en prolongación de la pala (1) y sobrepasando destacadamente el borde trasero de la cabeza (4), existe una extensión (5) que tiene en su canto una dimensión suficiente para proporcionar un apoyo efectivo al dedo medio (6) de la mano del usuario facilitando que actúe en cooperación con los dedos pulgar (7) e índice (8) durante la manipulación de la llave.
Patent ES-2261074-B1 (ES)
Title: Sistema de regeneracion de carga de baterias.
Inventor: LOYACONO PARDO GABRIEL
IPC: H02J7/04
Filed: 2005-04-13
Granted: 2007-11-16
Abstract: Sistema de regeneración de carga de baterías, en particular para equipos portátiles de medidas de señales de televisión que dispone de medios de control constituidos por un microprocesador (1) un sensor (5) y un limitador de corriente-tensión (3) que actuando sobre la corriente, la tensión y la temperatura de la batería 7 controlan el proceso de regeneración de dicha batería 7.
Patent ES-2274700-B1 (ES)
Title: Indicador de velocidad.
Inventor: OHASHI HAYATO
IPC: G01D7/00
Filed: 2005-07-07
Granted: 2008-05-01
Abstract: Indicador de velocidad. Problema: Mejorar la visibilidad de un indicador de velocidad. Solución: Una porción indicadora de información de batería incluyendo un primer cuadro arqueado (104), una porción indicadora de valor de velocidad (108), y una porción indicadora de región incluyendo un segundo cuadro arqueado (106), se visualizan concéntricamente en una pantalla de cristal líquido (102) de un indicador de velocidad (100), y un indicador (140) aparece en la pantalla de cristal líquido (102). Cuando una motocicleta de pila de combustible (10) con el indicador de velocidad (100) montado avanza, por ejemplo, a 30 km/h, el indicador (140) pivota hasta la posición correspondiente a "35" y "0", "10", "20", y "30" que el indicador (140) ha pasado en la porción indicadora de valor de velocidad (108) desarrollan color. Además, en la porción indicadora de región, se ilumina la región desde "0" en la porción indicadora de valor de velocidad (108) hasta la punta del indicador (140).