Patent SG-11201407184P-A (SG)
Title: Process for preparation of optically pure and optionally substituted 2- (1 -hydroxy- alkyl) - chromen - 4 - one derivatives and their use in preparing pharmaceuticals
Inventor: RAMAN JAYARAMAN VENKAT
IPC: C07D311/36
Filed: 2013-05-03
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 7 November 2013 (07.11.2013) WIPOIPCT (10) International Publication Number WO 2013/164801 A1 (51) International Patent Classification: C07D 311/36 (2006.01) C07D 405/06 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/IB2013/053544 3 May 2013 (03.05.2013) English English (30) Priority Data: 1737/CHE/2012 61/671,956 4 May 2012 (04.05.2012) IN 16 July 2012 (16.07.2012) US (71) Applicant: RHIZEN PHARMACEUTICALS SA [CH/CH]; Fritz Courvoisier 40, CH-2300 La Chaux de Fonds (CH). (72) Inventors: RAMAN, Jayaraman Venkat; 201, Florence Exotica, 14/1, Lane # 3; Arunoday Society, Alkapuri, Vadodara 390003 (IN). VAKKALANKA, Swaroop Ku­ mar Venkata Satya; Rhizen Pharmaceuticals SA, Fritz Courvoisier 40, CH-2300 La Chaux de Fonds (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) © 00 •t i-H en i-H o CJ (54) Title: PROCESS FOR PREPARATION OF OPTICALLY PURE AND OPTIONALLY SUBSTITUTED 2- (1 -HYDROXY- ALKYL) - CHROMEN - - 4 ONE DERIVATIVES AND THEIR USE IN PREPARING PHARMACEUTICALS (57) Abstract: The present invention relates compounds useful to as pharmaceutical intermediates, processes to for preparing the in­ termediates, to intermediates used in the processes, and to the use of the intermediates in the preparation of pharmaceuticals. In par­ ticular, the present invention concerns enantiomerically pure optionally substituted 2-(l-hydroxy-alkyl)- chromen-4-one derivatives represented by formula (IA) and (IB), processes for preparing the alcohol derivatives and their use in preparing pharmaceuticals.