baber/WOPTO huggingface dataset:
Patent CA-3161510-A1 (CA)
Title: Procede ameliore de culture de lymphocytes infiltrant les tumeurs a usage therapeutique
Inventor: CORDES ULRIK
IPC: A61P31/12
Filed: 2020-12-18
Abstract: La présente invention a pour but de revigorer des lymphocytes infiltrant les tumeurs (TIL) épuisés in vitro par la co-culture des TIL excisés contenant des fragments tumoraux avec des inhibiteurs de points de contrôle, la stimulation des TIL avec d'autres interleukines connues pour inverser l'épuisement des lymphocytes T et/ou l'inhibition de l'effet des facteurs sécrétés par des lymphocytes T régulateurs (tels que l'IL-10) ce qui permet de créer un microenvironnement tumoral favorable (TME) dans lequel les lymphocytes T épuisés peuvent se développer plus rapidement et atteindre des taux plus élevés qu'avec les protocoles de développement de TIL établis actuellement.
Patent CA-3161988-A1 (CA)
Title: Knitted structure for reinforcing composite materials
Inventor: DUMONT Nicolas
IPC: D04B1/14
Filed: 2020-11-19
Abstract: The object of the invention is a composite product that may include a knitted reinforcing structure (300), which has at least two skins (310, 320), connected by links (330); the link density being between 1 link per 40 square stitches and one link per 10,000 square stitches, which may include between 55 and 85% by volume of polymeric material and between 15 and 45% by volume of reinforcing fibers. The invention also relates to the method for producing the composite product.
Patent CA-3164889-A1 (CA)
Title: Systems, computer program products, and methods for building simulated worlds
Inventor: GILDERT SUZANNE
IPC: G16Z99/00
Filed: 2022-06-22
Abstract: Systems, computer program products, and methods for constructing models and simulations of real-world environments are described. A robot employs various sensors to collect data from its environment and provides this data to a tele-operation system. Any number of tele-artists may access the tele-operation system and use the robot sensor data to collaboratively construct a simulated scene representative of the robot's environment. The tele-artists may continue to update the simulation in real-time as the robot explores its environment and provides more sensor data. The robot may use the simulation in support of fundamental operations through its cognitive architecture, such as action planning and hypothesis generation. An artificial intelligence controller of the robot may monitor the adaptations made to the simulation by the tele-artists in response to the sensor data in order to learn (e.g., via reinforcement learning) how to autonomously generate and update its own simulation based on its own sensor data.
Patent CA-3167029-A1 (CA)
Title: Devices and methods for positioning a guidewire
Inventor: KOTMEL ROB
IPC: A61M25/09
Filed: 2021-01-14
Abstract: A method for positioning a guidewire may comprise arranging an inner shaft at least partially within a catheter lumen of a catheter such that the inner shaft is positioned at a proximal limit of longitudinal movement of the inner shaft relative to the catheter, advancing a guidewire into a shaft lumen of the inner shaft until the guidewire is located at a predetermined longitudinal offset distance relative to the catheter, locking the advanced guidewire relative to the inner shaft while the inner shaft is at the proximal limit; and positioning the guidewire at least in part by advancing the inner shaft.
Patent CA-3167454-A1 (CA)
Title: A satellite communication terminal for iot applications
Inventor: LEVER DUBI
IPC: G16Y40/10
Filed: 2022-07-11
Abstract: A method for satellite communication over non-geosynchronous orbit (NGSO) satellites, using a terminal having a non-tracking antenna, is presented. The terminal may communicate with an NGSO satellite each time the NGSO satellite passes through the tenninal's antenna beam (communication opportunity). Though the communication opportunities are short and may reoccur at relatively long intervals (e.g., minutes to tens of minutes), these communication opportunities may be sufficient for transmitting the volumes of information generated by Internet of Things (IoT) applications during the intervals between communication opportunities.
Patent CA-3167760-A1 (CA)
Inventor: KHAN AVIK
IPC: C08J3/22
Filed: 2021-03-10
Abstract: A biopolymer composite of the invention comprising a) an alginate salt, b) chitosan, c) a plasticizer, d) a compatibilizer, and e) a thermoplastic polymer, wherein the alginate salt, the chitosan, the plasticizer and the compatibilizer are dispersed in a matrix of the thermoplastic polymer, is provide. A method, a masterbatch and a kit producing the biopolymer composite are also provided. Finally, articles comprising the biopolymer composite are provided.
Patent CA-3170250-A1 (CA)
Title: Module de ciblage comprenant des ligands pd-l1 et/ou pd-l2 destine a etre utilise dans une methode de stimulation d'une reponse immunitaire a mediation par un recepteur d'antigene chimerique chez un mammifer
Inventor: EHNINGER ARMIN
IPC: A61K39/395
Filed: 2021-03-16
Abstract: La présente invention concerne un module de ciblage comprenant au moins un domaine de liaison aux ligands PD-L1 et/ou PD-L2, et un domaine de liaison de marqueur ou un marqueur destiné à être utilisé dans une méthode de stimulation d'une réponse immunitaire à médiation par un récepteur d'antigène chimérique chez un mammifère, un acide nucléique, un vecteur ou une cellule comprenant une séquence nucléotidique codant pour le module de ciblage, une composition pharmaceutique et un kit comprenant le module de ciblage et un vecteur ou une cellule comprenant une séquence nucléotidique codant pour un récepteur d'antigène chimérique permutable.
Patent CA-3172037-A1 (CA)
Title: Activity based host cell protein profiling
Inventor: QIU HAIBO
IPC: G01N33/68
Filed: 2021-02-27
Abstract: The present application provides methods and systems for identifying host cell protein impurities which have enzymatic activities in biopharmaceutical products and in samples during manufacturing processes. The present application provides various activity-based probes to characterize different enzyme classes of host cell protein impurities including probes containing functionalized molecules with reporter or affinity-based tags.
Patent CA-3172347-A1 (CA)
Inventor: FREUNDT MARTIN
IPC: B65G23/22
Filed: 2022-08-18
Abstract: Linear shafts are used in industry to passively guide carriages or to actively move carriages along the linear shaft by means of drive motors. Common motors for moving the carriages must be able to achieve both acceleration and deceleration of the carriages. Naturally, in particular for highly dynamic applications, motors with appropriate power must be used for the particular acceleration processes. An axial device 1 is proposed comprising a linear shaft 3, comprising at least one carriage 4, and comprising an electric drive 5 for moving the carriage 4 along the linear shaft 3, said axial device comprising a mechanical energy storage arrangement 6, the energy storage arrangement being able to assume a charging state for converting kinetic energy into potential when the carriage 4 is decelerated along the linear shaft 3 energy in an energy charging region 10, a storage state for storing the potential energy, and a discharging state for converting the stored potential energy into kinetic energy when the carriage 4 is accelerated along the linear shaft 3 in an energy releasing region 11.
Patent CA-3173918-A1 (CA)
Title: Targeted degradation of the oncogenic microrna 17-92 cluster by structure-targeting ligands
Inventor: DISNEY MATTHEW D
IPC: C07K9/00
Filed: 2021-03-24
Abstract: Embodiments of methods are disclosed for inhibiting, regulating and/or otherwise affecting or managing the pri-miR- 17-92 cluster, and certain pre-miRNA's embedded in the cluster as well as the pre-miRNA's themselves as isolated forms, as members of a library, present in oncogenic and/or polycystic cell lines and/or that are present in breast cancer, prostate cancer and/or polycystic kidney disease in animals or humans, or present in any other disease in which the pri-miR-17-92 cluster and the certain pre-miRNAs within in it cause or contribute to disease. The methods utilize compounds that target the structural feature or features of the pri-miR-17-92 cluster and/or the certain pre-miRNA's. The pre- miRNA's are members of the pre-miRNA-X group which includes one or more of pre-miR- 17, pre- miR-18a, pre-miR-19a, pre-miR-19b-1, pre-miR-20a, and pre-miR-92a-1 or any combination thereof. The compounds incorporate a dimeric formula of a binding moiety for the certain pre-miRNA-X's. The binding moiety can bind or complex with structural feature(s) of the certain pre-miRNA-X's without specificity for the particular nucleotide sequence of the structural features. The binding moiety nevertheless is selective for the certain structural feature(s) so that it does not bind with other pre-miRNA's not having the certain structural feature(s).
Patent CA-3175886-A1 (CA)
Title: Device for dewatering and method of making same
Inventor: CHAN CHRISTINA
IPC: C02F11/121
Filed: 2021-04-29
Abstract: The present disclosure generally relates to a device for dewatering a material. The device comprises a biodegradable, permeable enclosure configured for receiving the material through an inlet. The permeable enclosure comprises layered biodegradable textiles, an inner portion and an outer portion, derived from renewable resources. The inner portion has an apparent opening size between about 0.5mm and 3mm. The outer portion has a ratio of the minimum tensile strength in the warp direction to the minimum tensile strength in the weft direction of about 2.5.
Patent CA-3177899-A1 (CA)
Inventor: CASH JAMES
IPC: B01D53/40
Filed: 2021-02-05
Abstract: Method and apparatus for cleaning pollution control equipment, such as particulate removal devices, including wet electrostatic precipitators (WESP). The WESP may include a housing, at least one gas inlet in fluid communication with the housing, a gas outlet spaced from the at least one gas inlet and in fluid communication with the housing, one or more ionizing electrodes in the housing adapted to be connected to a high voltage source, and one or more collection electrodes in the housing. The housing may be in fluid communication with a flushing fluid source, such as a water source. The effective length of the collection electrodes is increased with extensions which add significant surface area to the collection electrodes while minimizing the corresponding height increase.
Patent CA-3179827-A1 (CA)
Title: A seeding row unit having a primary actuator to adjust depth and to raise and lower the seeding row unit
Inventor: DHOBALE DNYANESH
IPC: A01C7/08
Filed: 2022-10-25
Abstract: A row crop planter including a frame, a seed bin supported by the frame, the seed bin configured to hold seeds, and a plurality of agricultural row units coupled to one or more seed bins. Each of the plurality of row units includes a seed deposit assembly, including a disk to cut a furrow in the soil, gage wheel, and a seed deposit chute to direct seeds into the furrow.  A bar linkage is operatively connected to the seed deposit assembly. A  downforce actuator is operatively connected to the bar linkage and applies a force to the disk and to the gage wheel, to cut the furrow in the soil. A primary actuator is operatively connected to the bar linkage, wherein the primary actuator raises and lowers the seed deposit assemblies, and moves the disk into the soil to cut the furrow at a depth determined by the primary actuator and the gage wheel.
Patent CA-3180472-A1 (CA)
Inventor: CARTER MARY TERESA
IPC: A61M5/158
Filed: 2021-05-26
Abstract: L'invention concerne un dispositif d'insertion doté d'un mécanisme d'insertion automatique qui déplace une tête de perfusion et un ensemble aiguille d'une configuration rangée à une configuration d'insertion dans laquelle une canule de la tête de perfusion et une aiguille d'introduction de l'ensemble aiguille sont automatiquement insérées dans la peau d'un patient. Le dispositif d'insertion comprend également un mécanisme de rétraction automatique qui déplace l'ensemble aiguille vers une configuration rétractée dans laquelle l'aiguille d'introduction est retirée de la peau du patient.
Patent CA-3181680-A1 (CA)
Title: Encoding and expression of ace-trnas
Inventor: LUECK JOHN D
IPC: A61K31/7088
Filed: 2021-06-07
Abstract: This invention relates to compositions and methods for treating a disease or disorder associated with premature termination codon, Certain aspects of the invention relate to polynucleotides, vectors, and host cells, and uses thereof.
Patent CA-3185287-A1 (CA)
Inventor: LANCASTER ANDREW
IPC: G01R19/155
Filed: 2021-06-08
Abstract: A load-side voltage detection module for a metrology device includes a plurality of first resistors electrically coupled to a first load-side terminal, the first resistors being in series, a plurality of second resistors electrically coupled to a second load-side terminal, the second resistors being in series, a voltage divider electrically coupled between a first line-side terminal and a second line-side terminal, the voltage divider creating a reference voltage for the load-side voltage detection module, and a pulse generator to generate a pulse based on detection of voltage, the pulse indicating a voltage on at least one of the first load-side terminal or the second load-side terminal, above at least one threshold.
Patent CA-3185929-A1 (CA)
Title: Device for unloading of package contents
Inventor: GOLDBERG ANDREY RUDOLFOVICH
IPC: B65D5/74
Filed: 2021-07-20
Abstract: The claimed technical solution relates to arrangements mountable on packets for dispensing the contents thereof. An arrangement for dispensing the contents of a packet, positioned over an opening in said packet, comprises: a spout with side walls; a release valve; and a support element, wherein, in a closed position, the spout is situated beneath the release valve and is held in place on the support element, the release valve being provided with flaps capable of holding the side walls of the spout in place and of forming an aperture when the spout is transferred into an open position. The spout is capable of tilting into an open position at an angle of more than 90 degrees, and the edges of the side walls of the spout are free of fastenings on three sides. The spout has a pull-out element, and the support element is provided with slits. In the closed position, the spout is held in place by its side walls, which are situated in the slits in the support element. In addition, the flaps of the release valve hold the spout in the closed position on the support element.
Patent CA-3186451-A1 (CA)
Title: Hemangio colony forming cells and non-engrafting hemangio cells
Inventor: LANZA ROBERT
IPC: C12N5/0789
Filed: 2009-05-06
Abstract: Methods of generating and expanding human hemangio-colony forming cells and non-engrafting hemangio cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells, non-engrafting hemangio cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications. Human non-engrafting hemangio cells are a novel progenitor cell population that is related to but distinct from the hemangioblast and human hemangio-colony forming cells. The invention also provides compositions, preparations, and solutions comprising hemangio-colony forming cells, non-engrafting hemangio cells or cells differentiated therefrom. The compositions, preparations, and solutions include cryopreserved preparations and substantially purified preparations, as well as mixed compositions formulated in combination with related hemangioblast progenitor cell types that can engraft into the bone marrow.
Patent CA-3187450-A1 (CA)
Title: System and method for recording viewer reaction to video content
Inventor: PAZ GABRIEL SIGUENZA
IPC: H04N21/475
Filed: 2021-06-29
Abstract: A system and method for automatically recording viewer reactions to viewed video content. The system and method utilize a system that responds to pre-tagged segments of video content. Upon recognition of such a tagged segment, a video camera is activated to capture the viewer response. A composite video of the captured viewer response and the segment of viewed video is then created. The viewer is notified that the composite video has been created. The system and method also provide the viewer with options to share the video via social media.
Patent CA-3187539-A1 (CA)
Title: Procede de deshydrogenation oxydante
Inventor: GOODARZNIA SHAHIN
IPC: C07C11/04
Filed: 2021-08-11
Abstract: Des modes de réalisation de la présente invention donnés à titre d'exemples concernent des procédés et des systèmes permettant d'augmenter le rendement d'un réacteur de déshydrogénation oxydante (ODH). Un procédé donné à titre d'exemple comprend la régulation de la température d'une composition de gaz d'alimentation à moins de 250 °C. La composition de gaz d'alimentation s'écoule à travers un préchauffeur d'alimentation pour former un gaz d'alimentation chauffé, dans le préchauffeur d'alimentation, la composition de gaz d'alimentation étant chauffée à une température comprise entre 150 °C et 250 °C. Le gaz d'alimentation chauffé s'écoule dans le réacteur ODH moins de 15 secondes après avoir quitté le préchauffeur d'alimentation.
Patent CA-3188102-A1 (CA)
Inventor: KANG-FORTNER QING
IPC: C12Q1/6886
Filed: 2021-08-06
Abstract: La présente divulgation concerne, entre autres, des méthodes de traitement d'un patient qui a été diagnostiqué comme présentant une leucémie myélomonocytaire aiguë (le sous-type M4 de LMA), une leucémie monocytaire aiguë (le sous-type M5 de LMA), ou un syndrome myélodysplasique (SMD). Les méthodes consistent à administrer au patient une quantité thérapeutiquement efficace d'un agoniste du récepteur alpha de l'acide rétinoïque (KARA), ou d'un sel correspondant pharmaceutiquement acceptable. Dans un ou plusieurs modes de réalisation (par exemple, dans le traitement du SMD), l'administration de l'agoniste de KARA ou de son sel pharmaceutiquement acceptable commence avant de déterminer si le patient exprime un biomarqueur de KARA et/ou sans tenir compte de l'état du biomarqueur de KARA.
Patent CA-3189918-A1 (CA)
Inventor: BECICH MICHAEL JUSTIN
IPC: G16B30/00
Filed: 2021-09-03
Abstract: L'invention concerne des méthodes destinées à analyser des valeurs d'expression quantitatives de biomarqueurs d'un panel de biomarqueurs pour déterminer l'activité de la sclérose en plaque (par exemple, la progression de la sclérose en plaque) chez un sujet humain. L'invention concerne en outre des kits permettant de mesurer des valeurs d'expression quantitatives des marqueurs, ainsi que des systèmes informatiques et des modes de réalisation de logiciel de modèles prédictifs pour déterminer une activité de la sclérose en plaque (par exemple, la progression de la sclérose en plaque) chez des sujets humains sur la base des valeurs d'expression qualitatives des marqueurs.
Patent CA-3190047-A1 (CA)
Inventor: GODREAU CYRIL GILLES EMILE
IPC: B63B22/18
Filed: 2021-08-23
Abstract: Inter-array cable (IAC) assemblies, systems, and methods are disclosed in which a conductive cable between two floating platforms, e.g., floating wind turbine platforms, is suspended below the sea surface and above the seabed. One or more buoyancy sections are included in the cable, which reduces the static tension on the connection at the floating platform by reducing the suspended cable weight, and which provides geometric flexibility, allowing the IAC to comply with platform motions.
Patent CA-3194504-A1 (CA)
Inventor: HORL TIMO
IPC: B24B3/54
Filed: 2021-09-08
Abstract: The invention relates to a sharpening jig (1), in particular for holding a cutting tool (2) which is to be sharpened or polished and which includes a blade (2a), and for positioning the blade (2a) at least at one positioning angle (a) relative to a sharpening and/or polishing tool, e.g. a rolling sharpener (3). In order to be able to place the blade (2a) at different positioning angles and thus allow the sharpening jig to be used with more versatility, according to the invention, the sharpening jig (1) has at least two parts (5, 7a, 7b) which are movable relative to each other to set different positioning angles (a).
Patent CA-3197156-A1 (CA)
Inventor: SHRIVASTAVA AKHIL
IPC: C25B9/75
Filed: 2023-04-05
Abstract: The present disclosure is directed to a single sheet electrochemical cell bipolar plate for stack assembly comprising a single sheet of formable material having an anode side and a cathode side opposite the anode side, wherein the anode side and the cathode side have a different structural configuration, a plurality of water channels on the anode side, a plurality of hydrogen channels on the cathode side, a plurality of lands comprise a groove and a flange, and a seal positioned within the flange to provide a variable groove depth for the land.
Patent CA-3198480-A1 (CA)
Title: Aerogel enhanced bio-based building material
Inventor: TARIKU FITSUM
IPC: C04B38/08
Filed: 2023-05-02
Abstract: Described herein is bio-fiber-based building material wherein the thermal performance is improved by two to four-fold over the prior art Hemperete by identifying and incorporating performance-enhancing ingredients into a bio-fiber and binder mix using specifically developed mixing formulas.
Patent CA-3199601-A1 (CA)
Title: Benzoimidazole derivatives as pad4 inhibitors
Inventor: AMANS DOMINIQUE
IPC: C07D471/04
Filed: 2016-05-19
Abstract: Compounds of formula (I): (see formula I) wherein X, Y, R1 and R3-R11 are as herein defined, and salts thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosis, and psoriasis.