Patent SG-11201804243Q-A (SG)
Title: Anti-alpha-v integrin antibody for the treatment of fibrosis and/or fibrotic disorders
Inventor: CELIK ILHAN
IPC: C12Q3/00
Filed: 2016-11-22
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau irst0) ..... ..s,„,„.1 (43) International Publication Date r 1 June 2017 (01.06.2017) WIPO I PCT ID Hit (10) 1111111111111111111 WO International Ell 2017/088974 Publication 1111111111MICIEINEMEMMIII A2 Number (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07K 16/28 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, PCT/EP2016/001970 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 22 November 2016 (22.11.2016) KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (30) Priority Data: ZW. 62/258,626 23 November 2015 (23.11.2015) US 16164879.5 12 April 2016 (12.04.2016) EP (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicant: MERCK PATENT GMBH [DE/DE]; Frank- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, furter Strasse 250, 64293 Darmstadt (DE). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) Inventors: CELIK, Ilhan; Stuckerstrasse 8, 64673 Zwin- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, genberg (DE). STAUB, Eike; Gewuerzapfelweg 13, 64297 Darmstadt (DE). URBAN, Miriam; Talblick 4, 63849 LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Leidersbach (DE). RAAB, Sabine; Kapersburgstrasse 13, 61191 Rosbach (DE). SAMY, Eileen; 53 Summer St., GW, KM, ML, MR, NE, SN, TD, TG). Unit 1, Arlington, MA 02474 (US). BENDER, Andrew; Published: 210 Lowell Street, Reading, MA 01867 (US). HIGGIN- international to be without search report and republished BOTHAM, Georgianna; 28 Veranda Avenue, Tewksbury, upon receipt of that report (Rule 48.2(g)) MA 01876 WU, Yin; 7 Apache Avenue, Andover, (US). MA 01810 (US). XU, Daigen; 1 Hyacinth Drive, West- ford, MA 01886 (US). N .4t i t IN Cr \ (54) Title: ANTI-ALPHA-V INTEGRIN ANTIBODY FOR THE TREATMENT OF FIBROSIS AND/OR FIBROTIC DIS - GC of:, ORDERS 0 ---- (57) : The invention relates to the prophylaxis and/or treatment of fibrosis and/or fibrotic diseases by means of antibodies. I N Above all, the invention relates to the administration of an anti-alpha-v integrin (receptor) antibody to patients suffering from Il c:::, fibrosis and/or fibrotic diseases, including but not limited to systemic sclerosis (SSc). More specifically, the instant invention relates ei to the treatment of fibrotic diseases of the skin, lung, heart, liver and/or kidney by means of said antibody. Even more specifically, 0 the instant invention relates to the administration of a recombinant, de- immunized monoclonal antibody targeting av-integrins pa- tients suffering from systemic sclerosis, including, but not limited to systemic sclerosis of the skin, lung, heart and/or kidney by means of the anti-alpha-v integrin antibody DI17E6 and structural mutants or modifications thereof