Patent SG-11201408312U-A (SG)
Title: Method of preparing a composition based on hyaluronic acid
Inventor: BARG HEIKO
IPC: C08J3/075
Filed: 2013-06-14
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 December 2013 (19.12.2013) WIPOIPCT (10) International Publication Number WO 2013/185934 A1 (51) International Patent Classification: C08B 37/08 (2006.01) C08L 5/08 (2006.01) A61K 8/73 (2006.01) A61K31/728 (2006.01) A61K 47/36 (2006.01) A61L 27/52 (2006.01) C08J3/075 (2006.01) A61K9/00 (2006.01) C08J3/24 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 61/660,269 12004962.2 13000961.6 15 June 2012 (15.06.2012) 4 July 2012 (04.07.2012) 26 February 2013 (26.02.2013) PCT/EP2013/001782 14 June 2013 (14.06.2013) English English US EP EP (71) Applicant: MERZ PHARMA GMBH & CO. KGAA [DE/DE]; Eckenheimer Landstrasse 100, 60318 Frankfurt am Main (DE). (72) Inventors: BARG, Heiko; Siegfriedstr. 25, 69469 Wein- heim (DE). FRIEDRICH, Josef; Im Warmet 13, 69231 Rauenberg (DE). LIEBETRAU, Wolfgang; Theodor- Heuss-Str. 2, 61169 Friedberg (DE). VOIGTS, Robert, G.; 8236 Burgandy Dr., Windlake, WI 53185 (US). LIG- MAN, Tim, Stephen; 1305 Regent Drive, Mundelein, IL 60060 (US). (74) Agent: RICKER, Mathias; Wallinger Ricker Schlotter Tostmann, Zweibrueckenstrasse 5-7, 80331 Miinchen (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) •rt o\ oo i-H cn i-H o CJ (54) Title: METHOD OF PREPARING A COMPOSITION BASED ON HYALURONIC ACID (57) Abstract: The invention relates to a method of preparing composition, a the composition comprising crosslinked first a poly­ mer, optionally a second polymer, which may be crosslinked or non-crosslinked, and water, wherein the first and the second polymer are selected from polysaccharide, comprising a at least steps (i) to (iv): (i) crosslinking a mixture comprising the first polymer and water; (ii) subsequent to the crosslinking in step (i), terminating the crosslinking; (iii) optionally blending the product obtained in step (ii) with the second polymer; (iv) subjecting the product obtained in step (iii) to dialysis.