baber/WOPTO huggingface dataset:
Patent CA-2467892-A1 (CA)
Title: Methods and compositions for derepression of iap-inhibited caspase
Inventor: WELSH KATE
IPC: A61P21/00
Filed: 2002-11-21
Abstract: The invention provides isolated agents having a core peptide selected from t he group consisting of Core peptides 5 through 39 and 42 through 55, wherein th e agent derepresses an IAP-inhibited caspase. Also provided is an isolated age nt having a core structure selected from any of the structures shown in Figures 5, 9, 10, 14B, and 21-24 wherein said agent derepresses an IAP-inhibited caspase. The invention further provides a method of derepressing an IAP- inhibited caspase. The method consists of contacting an IAP-inhibited caspas e with an effective amount of an agent to derepress an IAP-inhibited caspase, the agent having a core motif selected from the group consisting of a core peptide having a sequence set forth in any of Core peptides 4 through 39 and 42 through 55, and a core structure selected from the group consisting of TPI759, TPI882,TPI914 or TPI927. The methods of the invention also can be us ed for promoting apoptosis in a cell and for reducing the severity of a patholo gy characterized by reduced levels of apoptosis. Methods for identifying agents that derepress an IAP-inhibited caspase are also provided.
Patent CA-2470136-A1 (CA)
Title: Raman amplification using a microstructured fiber
Inventor: ROMAGNOLI MARCO
IPC: H01S3/067
Filed: 2001-12-21
Abstract: A Raman amplifier comprising a microstructured fiber and at least one pump laser, optically connected to one end of the microstructured fiber. The pump laser is adapted for emitting a pump radiation at a wavelength .lambda.p, and the microstructured fiber comprises a silica-based core surrounded by a plurality of capillary voids extending in the axial direction of the fiber.  The core of microstructured fiber further comprises at least one dopant added to silica, said dopant being suitable for enhancing Raman effect.
Patent CA-2472415-A1 (CA)
Inventor: BEAUDRY SCOTT ALEXANDER
IPC: A61F13/38
Filed: 2004-06-25
Abstract: The present invention relates to a swab for treating wounds. The swab comprises a stick to one end of which is attached a wound treating element. The wound treating element has a wound cleansing element and a hemostat-containing element. A reservoir is provided for retaining a cleansing or other solution in fluid communication with the wound cleaning element.
Patent CA-2473901-A1 (CA)
Inventor: CAPUTO JIMMY C
IPC: G06Q10/06
Filed: 2003-02-25
Abstract: A medication-dispensing unit is provided for tracking medical products having a Radio Frequency Identification (RFID) tag uniquely associated therewith. The dispensing unit includes compartments for receiving medical products therein, and readers for reading the RFID tags associated with the medical products in the compartments. A processor is coupled to the readers for receiving and processing readings of the RFID tags in the compartment to identify the medical products in the compartments. The processor may identify a medical product removed from a compartment by determining a difference between readings of the RFID tags in the compartment taken before and after the medical product is removed from the compartment. The processor may verify that the medical product removed from the compartment is authorized to be removed or confirm that an identified patient is intended to receive the medical product being removed from the compartment.
Patent CA-2474326-A1 (CA)
Title: Arcuate taper lock anchor base plate and anchor assembly with the base plate
Inventor: SALDARELLI THOMAS A
IPC: E04H12/22
Filed: 2004-07-15
Abstract: An anchor assembly for supporting a post and a base plate for the assembly. The assembly includes a tubular anchor body with an arcuate interior area. The anchor body is configured to receive a post having an arcuate exterior profile and a hollow lower end. The base plate is for connection with the anchor body. The base plate has an arcuate portion shaped congruently to the anchor body. The base plate has an arcuate conical portion that has a cross-sectional area that is complementary to the hollow lower end of the post and that has a greatest radial dimension at a base of the conical portion. The greatest radial dimension is greater than a complementary dimension of an interior surface of the post to cause the interior surface to slide over the conical portion and the conical portion to frictionally engage the post to prevent lateral movement of the post.
Patent CA-2475117-A1 (CA)
Title: Method of joining wood based materials
Inventor: ALMQVIST DAVID
IPC: C09J161/24
Filed: 2003-02-05
Abstract: The present invention relates to a method of joining two or more pieces of wood based materials, comprising the steps of providing at least two pieces of wood based material; separately applying an adhesive composition (A), comprising a curable resin, and a composition (B), comprising a gel forming substance, onto at least one of said at least two pieces; joining the two pieces together to form an assembly having the compositions (A) and (B) situated between the pieces; pre-pressing the obtained assembly, with no curing of the resin; and then, hot-pressing the assembly to cure the resin. It also relates to wood based products made by the method.
Patent CA-2476289-A1 (CA)
Inventor: GOUIN STEVE
IPC: G01C9/00
Filed: 2004-08-17
Abstract: Méthode d'équerrage, de mesurage et de marquage, particulièrement dans la construction de limons d'escalier. Une équerre possède des rainures et une règles comportant aussi une ou des rainures dans lesquelles s'insère une attache permettant de définir les dimensions des pièces à découper sur place selon des axes variables par une graduation de l'équerre et le déplacement de la règle de manière à la coulisser dans les rainures. La même équerre peut servir de marches et de contremarches supportées par un limon plat.
Patent CA-2476490-A1 (CA)
Title: Indole derivatives substituted with long-chain alcohols and medicaments containing them
Inventor: YAMADA MASASHI
IPC: C07D209/12
Filed: 2002-02-13
Abstract: Provided is an indole long-chain alcohol represented by the following formula (I): wherein R1~, R2~, R3~ and R4~ each independently represents hydrogen atom, methyl group, acetyl group or hydroxyl group and n stands for a number from 0 to 20; and a medicament comprising the same. The compound (I) has an excellent nerve growth promoting effect, as well as antioxidative and anti-tumor effects, and thus is useful as a preventive and/or therapeutic drug for cerebral diseases such as dementia or malignant tumors such as cerebral tumor.
Patent CA-2476640-A1 (CA)
Inventor: CHEN PAUL N
IPC: B65F1/00
Filed: 2003-02-26
Abstract: A bag or liner (10) adapted to collect items comprises first and second thermoplastic body panels (112, 114), and at least one polymeric structure (218). The first and second body panels are joined along a pair of opposing sides and a bottom (20) bridging the sides so as to form an open mouth. The joined first and second body panels form an interior space for collecting items. The at least one structure is a patch, tape or pouch.
Patent CA-2477088-A1 (CA)
Title: Systemes de distribution d'agents actifs et methodes de protection et d'administration d'agents actifs
Inventor: OLON LAWRENCE P
IPC: A61K47/48
Filed: 2003-02-24
Abstract: La présente invention concerne des systèmes de distribution d'agents actifs, et plus particulièrement des compositions comprenant des acides aminés, tels que des acides aminés ou des peptides simples, fixés de manière covalente à des agents actifs, ainsi que des méthodes d'administration de compositions d'agents actifs conjugués.
Patent CA-2477244-A1 (CA)
Inventor: OSSE FRANCISCO J
IPC: A61F2/24
Filed: 2003-02-20
Abstract: A replacement venous valve assembly having over-the-wire or other deployable configurations of struts (210, 220, 230, 240) and membranes (250, 260).
Patent CA-2477321-A1 (CA)
Inventor: HRAFNKELSDOTTIR KOLBRUN
IPC: A61K9/00
Filed: 2003-02-24
Abstract: One or more mono- or diglyceride having the formula: (Fomula I); wherein R1, R2. And R3 are selected from the group consisting of from C6 to C26 fatty acids, PEG polymers and hydrogen, provided that at least one R1, R2 and R3 i s a C6-C26 fatty acid residue and at least one of R1, R2 and R3 is a PEG polym er residue for use as an absorption enhancing agent.
Patent CA-2477741-A1 (CA)
Inventor: FAGAN PATRICK C
IPC: C07F9/6512
Filed: 2003-02-28
Abstract: La présente invention concerne des mimétiques nucléosidiques du disphosphate et des mimétiques nucléosidiques du trisphosphate, qui contiennent des mimétiques de fragments du disphosphate ou du trisphosphate, et éventuellement des modifications par des sucres et/ou des modifications par des bases. Les mimétiques nucléotidiques de l'invention, qui se présentent sous forme de sel pharmaceutiquement acceptable, de promédicament pharmaceutiquement acceptable ou de formulation pharmaceutique, sont utiles comme agents antiviraux, antimicrobiens ou anticancéreux. L'invention concerne une méthode de traitement d'infections virales, d'infections microbiennes, ou de troubles à évolution chronique. Elle concerne en outre des compositions pharmaceutiques contenant les composés de l'invention associés éventuellement à d'autres agents pharmaceutiquement actifs.
Patent CA-2479374-A1 (CA)
Inventor: DELISLE GILLES L
IPC: F02B19/14
Filed: 2003-03-19
Abstract: ABSTRACT OF THE DISCLOSUREA fuel processing device (2) is provided that produces fuel aerosol particles (5) that when mixed with combustion air, reduces or eliminates detonation (knock) in internal combustion engines, reducing fuel octane requirements and improving burning characteristics of the fuel. The device includes an adapter (10) between fuel injector (12) and port (14) for the fuel injector, the adapter being of a hollow cylindrical configuration. A plurality of plates (46) are disposed in the adapter, plates (46) provided with a central opening (50), with radially extending slots (52) extending away from the central opening (50). Each slot has one edge configured with a vane (56) that creates turbulence in the air/fuel mix passing through the adapter so that larger droplets are broken up into smaller droplets until an optimum droplet size is reached.
Patent CA-2483752-A1 (CA)
Title: Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
Inventor: BUTORA GABOR
IPC: C07D519/00
Filed: 2003-04-25
Abstract: The present invention is directed to compounds of the formula (I): (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
Patent CA-2484600-A1 (CA)
Inventor: LEBEL LORRAINE ANN
IPC: A61K31/00
Filed: 2003-04-22
Abstract: L'invention concerne un procédé de traitement de certains troubles neurologiques et psychiatriques chez des mammifères, y compris chez des humains, consistant à administrer un inhibiteur sélectif de PDE10. En particulier, l'invention concerne le traitement de troubles de l'humeur, du déplacement et de l'anxiété; de la psychose; des troubles liés aux drogues, par exemple l'alcool, l'accoutumance; des troubles comportant un symptôme de déficience cognitive; ainsi que des troubles et des états pathologiques neurodégénératifs. L'invention concerne également l'utilisation de papavérine en tant qu'inhibiteur sélectif de PDE10. L'invention concerne encore des essais permettant d'identifier des composés chimiques présentant une activité en tant qu'inhibiteurs sélectifs de PDE10.
Patent CA-2492125-A1 (CA)
Title: A link generation system
Inventor: SCHUTZ JONATHAN JAMES
IPC: G06F17/00
Filed: 2003-07-11
Abstract: A link generation system, including a content discovery module for processin g data files of a network server to identify servable data, and a link generat or for generating links to the servable data to allow the servable content to b e accessed using the links. The link generator generates encoded links for accessing dynamically generated data of the network server, the encoded link s being in a form suitable for an indexing agent. The link generator processes a database of the network server to determine query data for retrieving servab le data from the database. A proxy server receives a request generated in response to selecting one of the encoded links, translates the request, and forwards it to the network server to access corresponding dynamically generated data. The link generation system generates links that can be used to access all of a web site's content, in particular content for which no accessible link previously existed, including dynamically generated content. This allows web site indexing spiders to index web site content that otherwi se would not be found or indexed, making it available to search engines.</SDOAB >
Patent CA-2497931-A1 (CA)
Title: Air conditioning system
Inventor: ROSTON EDWARD A
IPC: F24F1/26
Filed: 2005-02-22
Abstract: An air conditioning system has a compressor for compressing a liquid refrigerant to form a high pressure vapor which is fed to a condenser for cooling the vapor so that it returns to liquid state and fed to an evaporator. In the evaporator, the liquid is transformed back to a vapor which absorbs beat from the surroundings and provides cooled air. A receiver stores extra refrigerant which is used at low ambient temperatures to flood the condenser to facilitate operation at ambient temperature which are low compared to the ambient temperatures at which the capacity of the system is rated. A  shutoff valve is employed to isolate the high and low pressure elements of the system from each other to enable servicing or pumping down of the system. An accumulator prevents liquid from entering the compressor and a head pressure control maintains a minimum pressure on the high pressure side of the system to assure that the temperature and pressure of the liquid refrigerant remains high enough when the ambient temperature surrounding the condenser is low.
Patent CA-2499269-A1 (CA)
Title: Isolation of immunoglobulin molecules that lack inter-heavy chain disulfide bonds
Inventor: DAY MARIA
IPC: C07K16/18
Filed: 2003-09-11
Abstract: The current invention features methods for reliably and controllably separating immunoglobulin half antibodies from immunoglobulin whole antibodies, as well as purified immunoglobulin half antibody preparations an d purified immunoglobulin whole antibody preparations while preserving biological activity. These dissociated half antibodies can be chromatographically separated from whole antibodies. There are four known subclasses of IgG molecules: IgG1; IgG2; IgG3; and IgG4. IgG4 molecules diff er from the other IgG isotypes in that the disulfide bonds that link the two heavy chain subunits together do not always form. Due to the non-covalent interactions that hold the heavy chain subunits together, the heterogeneity of IgG4 molecules is not apparent following gel filtration of purified IgG4 protein. However, when purified IgG4 protein is separated by denaturing polyacrylamide gel electrophoresis (SDS-PAGE) under non-reducing conditions, two distinct protein species can be identified - whole antibody and "half- antibodies".
Patent CA-2499609-A1 (CA)
Inventor: YOKOMIZO SATORU
IPC: C12P7/62
Filed: 2003-10-10
Abstract: It is intended to develop a technique whereby the composition of a biodegradable copolymer polyester can be arbitrarily controlled while ensuring a high productivity at a low cost. Namely, a culture method for producing a copolymer polyester using a microorganism characterized in that the specific feeding speed of a fat to be used as a carbon source to a substrate is controlled at a definite level throughout the culture time or altered in the microbial cell growth phase and in the polyester accumulation phase during the culture but controlled at a definite level in each phase. A culture method of controlling the composition of a copolymer polyester product by appropriately selecting the type of a fat and/or the specific supplying speed of the fat to a substrate.
Patent CA-2501589-A1 (CA)
Inventor: MARION KARINE
IPC: C11D11/00
Filed: 2003-10-30
Abstract: The invention concerns a method for eliminating biofilm characterized in that it comprises at least the following steps carried out simultaneously or consecutively: a) providing a solution comprising at least an enzymatic mixture containing at least one enzyme selected from the group of proteases, at least one enzyme selected from the group of esterases and one amylase, b) providing a solution comprising a detergent having an alkaline pH, c) applying by washing or by circulation said solutions on the surface to be treated. The invention also concerns a kit for eliminating biofilm characterized in that it comprises said solutions and the compositions comprising said solutions.
Patent CA-2502458-A1 (CA)
Title: Steam water spray systems
Inventor: JONES GEOFFREY ARTHUR
IPC: D21G7/00
Filed: 2003-10-14
Abstract: An apparatus and method to use steam to atomize water to produce a mixture o f moisture and heat for application to the web of a paper machine for both production improvement and paper quality control. The method allows independent droplet size and heat control in the mixture, resulting in flexibility that can not be offered by conventional steam showers or water spray systems individually. In one embodiment the apparatus consists of a plurality of actuator nozzle modules (10) which control the water volume flo w feeding the nozzle (22) through a pneumatic pressure signal. Pressurized ste am feeding the nozzle (22) is used to break the water into fine droplets. The resulting nozzle spray is a mixture of moisture in fine water droplets and steam vapor, and heat stored in the steam. Alternatively, a plurality of ste am valves can be used to regulate the steam volume flow feeding each atomizing nozzle.
Patent CA-2503032-A1 (CA)
Title: Process and device for securing a low-altitude flight by an aircraft
Inventor: ESPINASSE JACQUES
IPC: G05D1/00
Filed: 2005-04-06
Abstract: The method involves determining a safety corridor, free from any obstacle such as crest. The corridor is delimited on both sides of a lateral path and its width depends on a global uncertainty. An aircraft exit avoiding unit (12) avoids any exit of the aircraft from the corridor, while guiding the aircraft along a flight path. The corridor is delimited by a highest part of ground existing under an uncertainty surface. An independent claim is also included for an aircraft comprising a device to secure a low altitude flight of the aircraft.
Patent CA-2504373-A1 (CA)
Inventor: SUOVANIEMI OSMO
IPC: B01L3/02
Filed: 2003-11-07
Abstract: L'invention concerne une pipette multicanaux dont le système de tube d'aspiration est conçu pour être élastique, une pointe jetable étant fixée de manière semblable à chaque tube d'aspiration indépendamment de la forme et des caractéristiques élastiques d'un râtelier de pointes. La pipette comprend un corps et un système de piston-cylindre présentant des tubes d'aspiration pour chaque canal. Chaque tube d'aspiration est ainsi adapté au corps, le tube d'aspiration étant mobile entre deux positions extrêmes dans le sens vertical par rapport au corps.
Patent CA-2504922-A1 (CA)
Inventor: HAGEN FREDERICK S
IPC: A61K49/00
Filed: 2003-11-04
Abstract: La présente invention concerne des procédés de criblage et d'identification d'agents dans une grande bibliothèque de structures moléculaires, lesquels agents peuvent modifier le clivage d'une protéine membranaire d'intérêt. Des agents identifiés par les procédés de l'invention et modifiant le clivage de la protéine membranaire peuvent être utilisés dans le traitement et la prévention de maladies, telles que les inflammations, le diabète, le cancer, la maladie d'Alzheimer, la maladie de Parkinson et analogues. Les procédés de l'invention sélectionnent et identifient des agents effecteurs qui se lient à la protéine membranaire d'intérêt pour modifier sa structure, de façon à moduler l'efficacité du clivage d'une sécrétase. Ces procédés sont également mis en oeuvre dans un système in vivo, qui crée des états physiologiques similaires ou identiques à ceux prévalant pour la maturation moléculaire de la protéine membranaire. Ces agents peuvent être choisis pour leur aptitude à augmenter ou diminuer l'efficacité du clivage de la sécrétase de la protéine membranaire.
Patent CA-2505399-A1 (CA)
Inventor: KWON DONG-SOON
IPC: C09K5/10
Filed: 2003-11-07
Abstract: Disclosed are a liquid heating element and a method for production thereof, and more particularly a solid ingredient A, a liquid ingredient B produced from the solid ingredient A, a liquid heating element produced from the liquid ingredient B and a method for producing the liquid heating element. The solid ingredient is produced by heating activated carbon, kaolin, copper sulfide and phosphoric acid (H3PO4) to a temperature ranging from 1,000 to 1,200 ~C. The liquid ingredient B is produced by mixing the solid ingredient A with silicon powder and distilled water and heating the mixture. The liquid heating element is produced by mixing the liquid ingredient B with ethylene glycol, leaving the mixture and then filtering the mixture. Since the liquid heating element is very stable and generates heat with minimum power consumption, it can be applied to various heat management systems.
Patent CA-2506734-A1 (CA)
Title: Fish disease models and uses thereof
Inventor: FLEMING ANGELEEN LOUISE
IPC: C12N15/85
Filed: 2003-12-01
Abstract: Generation and use of disease models, for instance in assays to identify and investigate genes and substances involved in disease and disease treatment, identification and use of drug targets. In particular, the present invention relates to generation and use of disease models in fish such as zebrafish. Gradable phenotypes may be generated in fish, allowing for degree of correction or alteration of an activity or effect of a treatment, gene or mutation to be assayed. Competing stimuli may be applied to fish in screens assaying for ability to affect an activity or effect of a treatment, gene or mutation. Example include any combination of an addictive drug, a visual stimulus, an audible startle stimulus, a temperature gradient, an electric shock, an aversive compound, a threatening shape or a dark area.
Patent CA-2507430-A1 (CA)
Title: Method for producing polybutylene terephthalate film
Inventor: KAGAWA SEIJI
IPC: B29C48/08
Filed: 2003-11-26
Abstract: In the method of the present invention, a molten polybutylene terephthalate resin is extruded from a T-die in the form of a film, the thus-obtained substantially undrawn film is slowly cooled so as to crystallize the polybutylene terephthalate resin, and then the thus-obtained crystallized fi lm is drawn.
Patent CA-2509377-A1 (CA)
Inventor: SCHMUCKI DANIEL
IPC: A61B17/02
Filed: 2002-12-09
Abstract: The invention relates to a joint (4) for movably connecting two stabilizing elements (2; 3), which comprises A) at least two joint segments (30; 31) which can be rotated relative each other, whereby B) one joint segment (30; 31) each is linked with one of the stabilizing elements (2; 3) each, and C) the joint (4) can be releasably locked by locking means (8), and D) said locking means (8) can be locked and/or unlocked by means of a fluid that is supplied and/or discharged via conduits (11).
Patent CA-2510281-A1 (CA)
Inventor: WENZEL WILLIAM R
IPC: E21B17/10
Filed: 2005-06-13
Abstract: A stabilizer comprised of a tubular body which has an exterior surface with selectively positioned indentations. A sleeve is positioned over the tubular body. The sleeve has an interior surface in contact with the exterior surface and a plurality of radial longitudinally oriented vanes. A plurality of radial apertures extend through the sleeve. The sleeve is secured to the body against rotation or axial movement by set screws. Each of the set screws extend through one of the apertures of the sleeve to engage on to the indentation in the exterior surface of the body.