baber/WOPTO huggingface dataset:
Patent NZ-503773-A (NZ)
Title: A process for the preparation of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity
Inventor: CHIESI PAOLO
IPC: C07D498/04
Filed: 1998-10-07
Abstract: Described are processes for preparing structural analogues of geneseroline, in particular aminocarbonyl derivatives, as in formula (I); wherein R is C2-C20 linear or branched alkyl, C3-C7 cycloalkyl, phenyl or benzyl, which can be substituted by C1-C4 alkyl, halogen or C1-C4 alkoxy group. The process via intermediates of formula (II) and (III), comprising of (a) oxidation of eserine with hydrogen peroxide in the presence of a base and subsequent hydrolysis to geneseroline, without isolating the intermediate geneserine; (b) acylation of geneseroline with an isocyanate of formula R-N=C=O, wherein is as defined above, in the presence of a basic catalyst. Included are intermediates in the reaction shown as formula (II); wherein R1 is isopropyl, tert-butyl or methoxymethyl, and formula (III); wherein R1 is a protective group for the phenolic hydroxyl, which must be stable in a basic environment and under strong reducing reaction conditions and can be removed in acidic conditions as intermediates. The compounds of formula (I); wherein R is selected from the group consisting of 2-ethylphenyl, 3-methylphenyl, 2-methylphenyl, These compounds are found to have acetylcholinesterase inhibiting activity and are useful for the treatment of Alzheimer disease and other neurovegetative pathologies.
Patent NZ-508844-A (NZ)
Title: Homogenous amorphous silicate catalyst containing a metal cationic species such as rhodium for catalysing the hydroformylation of olefins
Inventor: BORRMANN THOMAS
IPC: B01J31/22
Filed: 2000-12-13
Abstract: A homogeneous catalyst for hydroformylation reactions comprising or including: a) a substantially amorphous calcium silicate host, and b) a plurality of metal cationic species (preferably rhodium Rh(III) species) capable of catalysing a hydroformylation reaction, coordinated or bound to the host is disclosed.  Also disclosed are the methods for making such a catalyst and applications for these catalysts for the synthesis of a transition metal-containing silicate matrix, with rhodium as the metal in the form of rhodium containing calcium silicate, for catalysts in a continuous hydroformylation process.
Patent NZ-509802-A (NZ)
Title: Suspension concentrate formulation containing pyrimethanil
Inventor: DIMITROVA GALIA
IPC: C09K23/42
Filed: 1999-08-09
Abstract: An aqueous SC formulation comprising (i) a 50-80% w/v pyrimethanil, (ii) 0.2-5% w/v of a polyoxyethylene-polyoxypropylene block copolymer surfactant, and (iii) 0.2-5% w/v of naphthalene formaldehyde condensate surfactant. Also described is a formulation comprising (i) approximately 60% w/v pyrimethanil, (ii) approximately 5% w/v of an ethenylenoxy -propylenoxy block copolymer surfactant, (iii) approximately 1% w/v of sodium naphthalene formaldehyde condensate surfactant, (iv) approximately 5% w/v polymethyl methacrylate-polyethylene glycol graft copolymer, (v) approximately 6% w/v propylene glycol, and (vi) approximately 37.5% w/v water.
Patent NZ-509961-A (NZ)
Title: Membrane-separated, bipolar multicell electrochemical reactor
Inventor: BROMAN BARRY MICHAEL
IPC: H01M8/02
Filed: 1999-07-01
Abstract: A multicell assembly is constituted by alternately stacking two types of pre-assembled elements has a bipolar electrode holding subassembly and a membrane holding subassembly.  The alternate stack of elements is piled over a bottom end element.  The stack is terminated by placing over the last membrane holding element a top end electrode element. Each bipolar plate electrode holding element and each ion exchange membrane separator holding element includes a substantially similar rectangular frame piece, made of an electrically nonconductive and chemically resistant material of molded plastic material, having on its upper (assembly) face grooves for receiving O-ring type gasket means.  They also have an inner flange portion (19) recessed from a first planar face and an electrically non conducting retention counterflange (4, 15), and having through holes and recesses in coordinated locations disposed along two opposite sides of the rectangular frame forming, upon completion of the assembling, ducts for the separate circulation of the negative electrolyte and of the positive electrolyte through all the negative electrolyte flow chambers and all positive electrolyte flow chambers, respectively, in cascade. The bipolar reactor does not have inlet and outlet manifolds for the two electrolytes, the electrolytes flow through the respective flow chambers in a zigzag path that is essentially in hydraulic series or cascade mode.  Two orders of parallel flow channels can be defined in felt electrodes.  Each order defines a comb-shaped flow distributing channel work the parallel fingers of which interleave with the finger channels of the other order.
Patent NZ-514876-A (NZ)
Title: Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
Inventor: SOUTH MICHAEL S
IPC: C07D401/04
Filed: 2000-05-18
Abstract: Disclosed are compounds of formula (I), wherein: B is optionally substituted aryl or heteroaryl, A is a single covalent bond or (CH(R15))pa-(W7)rr, R1 is hydrido, alkyl, cyano, haloalkyl or halo, R2 is Z0-Q, wherein Z0 is a covalent single bond or CH2, and Q is an optionally substituted aryl or heteroaryl, Y0 is a radical of formula (IV), D5, D6, J5 and J6 are independently selected from C, N, O, S and a covalent bond. The compounds are used in the manufacture of medicaments for anticoagulant therapy.
Patent NZ-515015-A (NZ)
Title: Flow through chemical indicator for measurement of biocidal agents
Inventor: SCHINDLEY BRIAN E
IPC: A61L2/26
Filed: 2000-05-19
Abstract: A  single-use  cartridge (C)  contains  a  dose  of  a concentrated  decontaminant for  providing  a  decontaminant solution  upon mixing with water. The cartridge is  inserted into  the  well (16) of a decontamination system (A).  Fresh water  and  then the decontaminant solution are recirculated through  the  well  during  a  decontamination  cycle.   The cartridge  includes  a  porous  region,  through  which  the decontaminant  solution  flows. Impregnated  in  the  porous region  is  a  chemical indicator, such as  crystal  violet, which   gradually   changes  color  on   exposure   to   the decontaminant.  The  indicator provides a  semi-quantitative indication  of the integrated level of the decontaminant  in the   solution   over  time  for  determining   whether   an acceptable  level  of  the  decontaminant  was  present  for decontamination.
Patent NZ-521113-A (NZ)
Title: New CCR5 modulators: benzimidazoles or benzotriazoles
Inventor: BURROWS JEREMY
IPC: A61P37/04
Filed: 2001-03-06
Abstract: Compounds of formula (Ih), processes for preparing them, compositions comprising them and their use in modulating CCR5 receptor activity are disclosed, wherein the variables are defined in the specification.
Patent NZ-523700-A (NZ)
Title: Oxazolidinone derivatives as antimicrobials
Inventor: MEHTA ANITA
IPC: A61K31/496
Filed: 2001-07-16
Abstract: Substituted phenyl oxazolidinones compounds of formula I are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp. Also disclosed are processes for the synthesis of the abovementioned compounds.
Patent NZ-530169-A (NZ)
Title: Methods to mobilize progenitor/stem cells
Inventor: BRIDGER GARY J
IPC: A61K/
Filed: 2002-07-30
Abstract: Disclosed is the use of a polyamine compound that binds to the chemokine receptor CXCR4 to prepare a medicament (a) for use in a method to obtain progenitor and/or stem cells from a subject which method comprises administering an amount of said medicament sufficient to mobilize progenitor and/or stem cells into the peripheral blood; followed by harvesting progenitor and/or stem cells, or (b) for use in a method to effect regeneration of cardiac tissue in a subject.
Patent NZ-533237-A (NZ)
Title: Flavivirus vaccine delivery system
Inventor: KHROMYKH ALEXANDER A
IPC: C12N15/86
Filed: 2002-11-26
Abstract: An expression vector comprising: (i) a nucleotide sequence encoding a flavivirus replicon that is incapable of producing infectious virus wherein said flavivirus replicon encodes one or more mutated flaviviral non-structural proteins; (ii) an insertion site for a heterologous nucleic acid; (iii) a promoter operably linked to the nucleotide sequence encoding the flavivirus replicon; and (iv) at least one autoprotease-encoding nucleotide sequence.
Patent NZ-545622-A (NZ)
Title: Rotary roller reamer
Inventor: MCMANUS TERRY MICHAEL
IPC: E21B10/24
Filed: 2004-09-03
Abstract: A bore hole rotary reamer (1) includes a body (2) having cutters (4) contained in respective recesses (3) formed in the body (2). Each cutter (4) is rotatably mounted by one or more respective spindles (5). A bearing region (10) is formed by an inner bearing surface (11) rotatable on an outer surface of the spindle (5). At least one annular seal (12) about the spindle (5) prevents ingress of contaminant to the bearing region (10). A circumferential void (13) is formed between the inner bearing surface (11) and the outer bearing surface of the spindle (5) adjacent the seal (12). At least one passageway (17) extends in an axial direction of the spindle (5) to the circumferential void (13) and a piston (19) movable in the passageway (17) in response to supply of pressure to an outer side (19a) of the piston (19) from the environment which surrounds the reamer (1). The piston (19) transfers pressure to fluid in the cylindrical passage (17) on an inner side of the piston (19) to supply pressure to the circumferential void (13) and thereby to the seal (12) that is substantially determined by the pressure of the environment surrounding the reamer (1).
Patent NZ-546658-A (NZ)
Title: A method for dynamically braking an automatic washing machine basket
Inventor: CHANG ERIC E-LEE
Filed: 2006-04-19
Abstract: A method for dynamically braking a basket of an automatic washing machine comprising a spin tube coupled to the basket and an agitator shaft coupled to an agitator mounted in the basket, the method comprising: coupling the spin tube to the agitator shaft for cooperative rotation; applying a torque to the agitator shaft in a first torque direction to rotate the agitator shaft and thereby rotate the agitator and the basket; and maintaining the coupling of the spin tube and the agitator shaft while applying a torque to the agitator shaft in a second torque direction opposite the first torque direction to dynamically brake the agitator and the basket.
Patent NZ-548306-A (NZ)
Title: Centralized medication management system
Inventor: VANDERVEEN TIMOTHY W
IPC: G06F19/00
Filed: 2004-12-22
Abstract: A system and method for monitoring, managing, and controlling medication delivery from a central location is provided. A central computer displays medication orders and ongoing medication administrations for a health care facility. The central computer checks medication delivery against a database of medication administration guidelines, including guidelines for medication interactions with other medications and with patient conditions and provides an indication of any detected incompatibilities. A clinician at the central location, where the central location may be a pharmacy at the healthcare facility, may adjust the medication administration parameters in response to detected incompatibilities and communicate with a caregiver at the point of care to provide decision support.
Patent NZ-548334-A (NZ)
Title: Automatic washing machine with an impeller and auger providing toroidal and inverse toroidal washing motion for respective deep fill and low fill washing
Inventor: LABELLE KATHLEEN MARY
Filed: 2006-07-04
Abstract: The automatic washing machine has a perforated wash basket within an imperforate tub. A clothes mover consists of an annular impeller with multiple vanes to impart toroidal movement to the clothes during a deep fill wash cycle and an inverse toroidal movement during a low fill wash cycle. An auger is mounted to the impeller for rotation within the wash chamber to enhance the toroidal movement.
Patent NZ-549583-A (NZ)
Title: Water sump structure
Inventor: HART PETER LESLIE
IPC: F24J3/08
Filed: 2005-06-07
Abstract: A water sump structure (1) is provided. A channel, trough, trench or the like is formed as or provided with an impermeable member (7) for trapping water. One or more heat exchange pipes (6) for carrying a heat exchange fluid are located, in use, so as to pass through water trapped by the impermeable member thereby forming a heat exchange water sump structure.
Patent NZ-555840-A (NZ)
Title: Conjugates of insulin-like growth factor-1 (IGF-1) and poly (ethylene glycol)
Inventor: AMREIN BEAT
IPC: A61K47/48
Filed: 2005-12-21
Abstract: Provided is a conjugate consisting of an insulin-like growth factor-l (IGF-1) variant and poly(ethylene glycol) (pEG), characterized in that said IGF-1 variant has amino acid alteration(s) at amino acid positions 27, 37, 65, 68 of the wild-type IGF-l amino acid sequence so that one or more of amino acids 37, 65, 68 is/are lysine(K), amino acid 27 is a polar amino acid but not lysine, and said PEG is conjugated to said IGF-l variant via primary amino group(s). Further provided are corresponding IGF-1 variants and uses of the composition in the manufacture of a medicament for AlzheimerÆs disease.
Patent NZ-562008-A (NZ)
Title: Novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives and their use as a medicament
Inventor: MEGENS ANTONIUS ADRIANUS HENDRIKUS PETRUS
IPC: A61K31/403
Filed: 2006-05-24
Abstract: Disclosed is a compound of formula (I), or an N-oxide, a pharmaceutically acceptable addition salt, or a stereochemically isomeric form thereof, wherein X is CH2 or O, ring C is either selected from formulas (c-1) or (c-2), wherein Y1 is S, S(=O), S(=O)2, or NR10, and R10 and R11 may together from a ring as described, or ring C is selected from (c-4) or (c-5), wherein Y2 is O or NH, and wherein the other substituents are as defined in the specification. Also disclosed is the use of the compound for treating conditions mediated through the 5-HT2 or D2 receptor, or for treating central nervous system disorders such anxiety, depression, psychosis schizophrenia, migraine, and addictive properties of drug abuse.
Patent NZ-566463-A (NZ)
Title: Solid formulation of fungicidal mixtures
Inventor: WOLF HILMAR
IPC: A01N25/14
Filed: 2006-08-31
Abstract: Disclosed is a composition containing trifloxystrobin (Component I), at least one further active substance selected from tebuconazole and tolylfluanid (Component II), at least one dispersant selected from a reaction product of formaldehyde with sulfonated 1,1'-oxybis[methylbenzene] sodium salts, and Component I and Component II are present in a ratio of I:30 to 12:1. Also disclosed is a process for preparation of said composition and the use of said composition for the application of the agrochemical active substances present on plants and/or the environment.
Patent NZ-570388-A (NZ)
Title: Improvements related to multi-fold panel assemblies
Inventor: NICHOLSON DAVID
IPC: E05D15/06
Filed: 2008-08-07
Abstract: Disclosed is a multi-fold panel assembly which includes a frame, at least a first and a second panel, and a pivot providing unit. The pivot providing unit is configured to allow pivoting movement of the panels from a closed position, wherein the panels are aligned with the plane of the frame and are mounted within the frame; to an intermediate position, wherein the panels are concertinaed and the plane of the panels is substantially perpendicular to the plane of the frame; to an opened position, wherein the panels are concertinaed and pivoted toward substantial alignment with the plane of a surrounding wall surface and remote from the frame. The pivot providing unit includes at least one primary portion movably engaged with the frame; at least one secondary portion positioned remote from the plane of the frame and pivotally connected to the primary portion at a first pivot point and pivotally connected to a side edge of the second panel at a second pivot point. The plane of the secondary portion as it pivots the side edge of the second panel from the intermediate position to the closed position on the primary portion is offset from the plane of the primary portion.
Patent NZ-575615-A (NZ)
Title: Piperidine or piperazine substituted tetrahydro-naphthalene-1-carboxylic acid mtp inhibiting compounds
Inventor: MEERPOEL LIEVEN
IPC: A61K31/445
Filed: 2007-10-22
Abstract: Disclosed are compound of formula (I), wherein the substituents are as defined in the specification, and processes for their preparation. The compounds have apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity and are useful in the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
Patent NZ-584731-A (NZ)
Title: Fumigation products containing dibromonitromethane and their use in methods of disinfecting and controlling pests
Inventor: FRIM RON
IPC: A01N33/18
Filed: 2005-12-08
Abstract: Disclosed is a method of disinfecting a substance, product or structure comprising fumigating the substance, product or structure with a pesticidally effective amount of dibromonitromethane thereby disinfecting the substance, product or structure. Further disclosed is an article of manufacturing, comprising a packaging material and a formulation being identified for use in the control of plant pests, said formulation including, as an active ingredient, a pesticidally effective amount of dibromonitromethane, and a carrier suitable for fumigation, said carrier including at least one compound selected from the group consisting of an alkane, a cycloalkane, an alcohol, a paraffin and an isoparaffin.
Patent NZ-585090-A (NZ)
Title: Quinoline derivatives and their use as tyrosine kinase inhibitors
Inventor: WESTMAN JACOB
IPC: A61P35/00
Filed: 2008-11-14
Abstract: Disclosed herein are quinolone derivatives of formula (I), wherein the substituents are defined within the specification, methods for their preparation, compositions comprising said compounds. Said compounds are useful in the treatment of a disorder selected from cancer, diabetic retinopathy, age-related macular degeneration, inflammation, stroke, ischemic myocardium, atherosclerosis, macular edema and psoriasis.
Patent NZ-591333-A (NZ)
Title: Sacrificial electrode design and delivery species suitable for prolonged iontophoresis application periods
Inventor: EISCHEN KATHLEEN A
IPC: A61N1/30
Filed: 2009-08-31
Abstract: Disclosed is a wearable iontophoresis device for the prolonged delivery of a positively charged pharmaceutical species from a salt formulation (such as donepezil hydrochloride) comprising: (a) a readily oxidisable metal-based sacrificial anode (such as silver) in the form of a generally planar layer having a connecting neck area that has a width that is generally 5% or more of the maximum electrode width dimension such that said sacrificial anode will remain connected for the desired operating life of the sacrificial anode; wherein the sacrificial anode is configured to have a minimum operating life of at least 6 hours under skin-safe conditions and is entirely consumed during the prolonged operation of the sacrificial anode; and (b) a drug delivery gel pad in electrical contact with said anode for accommodating a gel containing a positively charged pharmaceutical species in salt form formulated for transdermal delivery.
Patent NZ-593019-A (NZ)
Title: Il-3 inhibitors in use for treatment of rheumatoid arthritis in an early stage
Inventor: MACK MATTHIAS
IPC: A61K39/00
Filed: 2009-12-04
Abstract: Disclosed is the use of an IL-3 inhibitor for prophylactic treatment of rheumatoid arthritis, for treatment of rheumatoid arthritis in an early stage, during early phases of exacerbation, or as maintenance therapy to prevent disease flares or disease progression.
Patent NZ-594383-A (NZ)
Title: Aminopyrimidines useful as kinase inhibitors
Inventor: BINCH HAYLEY
IPC: A61K31/505
Filed: 2006-11-03
Abstract: ABSTRACT - 594383 Disclosed are aminopyrimidine compounds of formula (I), wherein the variables are as defined in the specification. These compounds are used for inhibiting Aurora protein kinase activity and are suitable for the treatment of a proliferative disorder selected from melanoma, myeloma, leukemia, lymphoma, neuroblastoma, or a cancer selected from colon, breast, gastric, ovarian, cervical, lung, central nervous system, renal, prostate, bladder, pancreatic, brain, head and neck, kidney, liver, melanoma, sarcoma, and thyroid cancer.
Patent NZ-597915-A (NZ)
Title: Combination therapy for treatment of immune disorders
Inventor: DE WAAL MALEFYT RENE
IPC: A61K31/35
Filed: 2008-02-26
Abstract: 597915 Disclosed is the use of an antagonist antibody to IL-23, or an antigen binding fragment thereof in the manufacture of a medicament for treating a subject having cancer or exhibiting a flare up of an autoimmune disease, wherein the medicament is for use in a dosage regimen comprising: a) administration of the medicament in a series of one or more doses over a first time interval; and b) administration of an acute phase therapeutic agent comprising an antagonist antibody or antigen binding fragment thereof that specifically binds to a cytokine or a receptor for a cytokine, selected from the group consisting of IL-1, TNF-?, IL-17A, and IL-17F in a series of one or more doses over a second time interval, wherein the second time interval (i) begins before or at the same time the first time interval begins and (ii) ends before the first time interval ends.
Patent NZ-600648-A (NZ)
Title: Novel substituted triazole derivatives as gamma secretase modulators
Inventor: VAN BRANDT SVEN FRANCISCUS ANNA
IPC: A61K31/4196
Filed: 2011-01-12
Abstract: The disclosure relates to substituted triazole derivatives of formula (I) wherein the variables Het1, R1, R2, A1, A2, A3, A4, L1, and L2 are as defined in the specification. These substituted triazole derivatives are useful as gamma secretase modulators. The disclosure further relates to processes for preparing these compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament. These gamma secretase modulators of formula (I) are suitable for use in the treatment or prevention of a disease or condition selected from Alzheimer’s disease, traumatic brain injury, mild cognitive impairment, senility, dementia, dementia with Lewy bodies, cerebral amyloid angiopathy, multi-infarct dementia, dementia pugilistica, Down’s syndrome, dementia associated with Parkinson’s disease and dementia associated with beta-amyloid.
Patent NZ-601650-A (NZ)
Title: A Word Forming Game
Inventor: HUNTLEY ALISON GRACE
IPC: A63F1/02
Filed: 2012-08-03
Abstract: A word forming game comprises a) a plurality of first pieces, b) a plurality of second pieces and c) a set of rules. Each first piece bears one letter of the alphabet and each second piece bears more than one letter of the alphabet. The rules direct that i. a player must draw a plurality of the first pieces and at least one of the second pieces; ii. the player must use the first and second pieces to create words by placing the first playing pieces in proximity to the second playing piece; iii. the player must draw further first pieces and place these proximate pieces already used to make a word to make further words; iv. the player may rearrange the first and second pieces to create new or different words; and v. a game score be allocated to the player depending on the word(s) created from the first and second pieces.