baber/WOPTO huggingface dataset:
Patent NZ-596734-A (NZ)
Title: Reversal of l-dopa-induced dyskinesia by neuronal nicotinic receptor ligands
Inventor: JORDAN KRISTEN G
IPC: A61P25/00
Filed: 2010-06-15
Abstract: 596734 Disclosed is the use of a compound which selectively targets both α4β2* and α6β2* for the manufacture of a medicament for treating, reducing, or delaying progression of L-dopa-induced dyskinesia or abnormal involuntary movements. Further disclosed is a combination comprising: a. L-dopa; and b. one or more compound, which selectively targets both α4β2* and α6β2*.
Patent NZ-598753-A (NZ)
Title: Component assembled from two parts, typically for supporting suspended ceiling, assembled by annular arcuate sections bent out of an engagement plane, engaging with each other on rotating components together
Inventor: STUDNIORZ THILO
IPC: E04B9/18
Filed: 2010-09-23
Abstract: The disclosure relates to an assembled component comprising a first and a second component. The first component comprises a first flat two-dimensional connecting region, and the second component comprises a second flat two-dimensional connecting region connected to the first connecting region. The connecting regions each comprise at least two connecting sections, which are in each case formed as material sections bent out of the plane of the respective connecting region. The connecting regions each have a substantially arcuate edge. One end of the arcuate edge is arranged at a distance in a direction perpendicular to the plane of the respective connecting region. The end of the arcuate edge is adjoined by a further edge of the connecting region which runs obliquely or transversely with respect to the arcuate edge. The connecting sections each comprise a guide surface running obliquely with respect to the plane of the respective connecting region. In each case two connecting sections engage with one another, wherein in each case a guide surface of a connecting section of the first connecting region rests, at least in some areas, on a guide surface of a connecting section of the second connecting region.
Patent NZ-599008-A (NZ)
Title: 2-amino-5, 5-difluoro-5, 6-dihydro-4h-oxazines as bace 1 and/or bace 2 inhibitors
Inventor: BANNER DAVID
IPC: A61K31/535
Filed: 2010-12-06
Abstract: 599008 Disclosed are 2-Amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)- phenyl]-amide derivatives of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes. Examples of a compound of formula (I) are: 5-Cyano-pyridine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide hydrochloride; 5-Fluoro-pyridine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide and 3-Chloro-pyridine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide.
Patent NZ-600377-A (NZ)
Title: Single-use containers and uses thereof
Inventor: GOL ARASH
IPC: B65D17/28
Filed: 2010-12-24
Abstract: A single-use container comprising a reservoir 10 that comprises a sterile liquid formulation, where the reservoir 10 is in fluid communication with an outlet adapted to be opened in order to dispense the formulation in an aseptic manner. The formulation is formulated for ingestion, consists essentially of a nutritional supplement and is substantially free of any flavouring agents.
Patent NZ-601652-A (NZ)
Title: Set of probes for the detection and typing of 46 human papillomavirus mucosal types
Inventor: GOLESKI VANESSA
IPC: C40B40/06
Filed: 2011-01-19
Abstract: Disclosed is a method of detecting and genotyping a human papillomavirus (HPV) type infection in a sample comprising: a) adding primers suitable for amplifying the L1 region of HPV to a sample suspected of comprising at least one HPV type; b) incubating the sample under conditions suitable for DNA amplification; c) adding a probe having a nucleotide sequence as set forth in SEQ ID No. 46, said probe binding to only HPV-97 under hybridisation conditions, said probe further comprising a unique tag; d) incubating said probe and said sample under conditions suitable for hybridisation; and e) detecting hybridisation of said tagged probe. Please note that the sequences are as disclosed in the specification.
Patent NZ-615257-A (NZ)
Title: Hla-restricted, peptide-specific antigen binding proteins
Inventor: CHEUNG NAI-KONG
IPC: C07K16/28
Filed: 2012-02-13
Abstract: Disclosed is an isolated antigen-binding protein (eg an antibody) or antigen-binding fragment that specifically binds to an epitope on an human leukocyte antigen (HLA)/peptide complex.
Patent NZ-619002-A (NZ)
Title: Ablutionary system
Inventor: SANSUM NIGEL PAUL
IPC: E03C1/046
Filed: 2012-05-21
Abstract: A customizable ablutionary system includes a modular mixer valve (1) having a main body part (2) housing a valve for connection to supplies of hot and cold water. A detachable accessory part (8) is connected to the main body part (2) via a transfer port to receive outlet water from the valve. The accessory part (8) has an outlet (4) separate from the transfer port for connection to a water delivery device such as a flexible hose for a shower handset. The system can be customized by connecting different accessory parts (8) having different functionality (measuring water temperature, holding USB dock etc.) to the main body part (2). In other embodiments the outlet may be provided in the main body part. Several accessory parts may be connected in series and water may flow through none, some or all of the accessory parts.
Patent NZ-624871-A (NZ)
Title: Tdp-43 specific binding molecules
Inventor: HOCK CHRISTOPH
IPC: C07K16/18
Filed: 2012-10-26
Abstract: Provided are novel TDP-43 -specific binding molecules including polypeptides such as human antibodies, as well as fragments, derivatives and variants thereof. Also provided are methods related to these TDP-43 specific binding molecules. Assays, kits, and solid supports related to TDP-43 -specific binding molecules, including polypeptides such as, human antibodies are also disclosed. The TDP-43-specific binding molecule, antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for TDP-43 targeted immunotherapy and diagnosis, respectively.
Patent NZ-629383-A (NZ)
Title: A metal structure with heavy duty corner elements
Inventor: KAHATAPITIYA ALGAMA NADIE
IPC: H05K5/04
Filed: 2012-10-01
Abstract: A framework for an electronics cabinet or server rack with bars connected by heavy-duty square corner brackets or blocks is described. The cabinet allows for greater strength and stability at the corners of the framework. The bars (2a-c) include spaced (Y) non-threaded holes (5a-d). The die-cut block (1) includes threaded holes, used to connect it to the bars by screws or other threaded fasteners (3a-f). The framework includes rails that are attachable between the bars using a threaded block.
Patent NZ-702341-A (NZ)
Title: Merchandiser including frame heaters
Inventor: RASCH JOHN M
IPC: A47F3/04
Filed: 2014-11-26
Abstract: A conventional merchandiser frame heater is a single, continuous frame heater that applies heat to all parts of the frame. While most of the condensation arises at lower areas of the frame, the existing frame heater inefficiently applies the same amount of heat to the entire frame. A disclosed refrigerated merchandiser has: a case defining a product display area and including a frame having a mullion, the mullion defining an opening to the product display area; a door coupled and movable relative to the frame over the opening to provide access to the product display area; a refrigeration system in communication with the product display area to condition the product display area; a first heater coupled to and routed along the frame; a second heater coupled to and routed along the frame, the second heater separate from the first heater; and a controller operatively coupled to the first heater and the second heater and programmed to control the first heater and the second heater relative to each other so a duty cycle for the first heater is the same as a duty cycle for the second heater to remove or inhibit formation of condensation. Another disclosed refrigerated merchandiser has: a case defining a product display area and including a frame having a mullion, the mullion defining an opening to the product display area; a door coupled and movable relative to the frame over the opening to provide access to the product display area; a refrigeration system in communication with the product display area to condition the product display area; a first heater coupled to and routed along the frame, the first heater having a first Watts-per-unit length value; a second heater coupled to and routed along the frame, the second heater separate from the first heater and having a second Watts-per-unit length value different from the first Watts-per-unit length value; and a controller operatively coupled to the first heater and the second heater and programmed to control the first heater and the second heater to remove or inhibit formation of condensation so that the first heater and the second heater are activated or deactivated at the same time. A related method of operating a refrigerated merchandiser is disclosed. Due to the cooperative control of the first heater and the second heater, condensation can be efficiently removed.
Patent NZ-703765-A (NZ)
Title: Gypsum-panel for acoustical monolithic ceiling
Inventor: DUGAN ERIN
IPC: E04B1/84
Filed: 2013-06-24
Abstract: An acoustical panel for forming a monolithic ceiling or wall, the panel extending across a rectangular area, and having a core made primarily of gypsum, the core being essentially coextensive with the panel area such that it has two opposed sides, each of an area substantially equal to the area of the panel, the core having a multitude of perforations extending generally between its sides, the perforations being distributed substantially uniformly across the full area of the core and being open at both sides of the core, the face side of the core being covered by a porous layer, the perforations being optionally restricted at a rear side of the core, the porous layer at the face side of the core being suitable for adherence of drywall joint compound and a water-based non-blocking paint.
Patent NZ-708177-A (NZ)
Title: Process for preparing nucleoside prodrugs
Inventor: MCGUIGAN CHRISTOPHER
IPC: C07H19/16
Filed: 2013-11-15
Abstract: A process for preparing phosphoramidates of nucleosides where a desired enantiomer, having regard to the asymmetric chiral centre of the phosphorus atom P, is provided in an enriched amount. The process comprises admixing a nucleoside with a phosphorochloridate in the presence of a catalyst comprising a metal salt selected from the group consisting of salts of Cu Fe, La and Yb.
Patent NZ-710323-A (NZ)
Title: Methods, systems, and software for identifying bio-molecules using models of multiplicative form
Inventor: COPE GREGORY ALLAN
IPC: G16B35/00
Filed: 2014-01-29
Abstract: The present invention provides methods for identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. More specifically, some embodiments of the present invention provide methods for building sequence-activity models comprising multiplicative terms and using the models to guide directed evolution. In some embodiments, the sequence-activity models include one or more interaction terms, each of which including an interaction coefficient representing the contribution to activity of two or more defined residues. In some embodiments, the models describe relation between protein or nucleic acid sequences and protein activities. In some embodiments, the present invention also provides methods for preparing sequence-activity models, including but not limited to stepwise addition or subtraction techniques, Bayesian regression, ensemble regression and other methods. The present invention further provides digital systems and software for performing the methods provided herein.
Patent NZ-710411-A (NZ)
Title: Pyrrolo [2, 3 -d]pyrimidine derivatives as inhibitors of janus- related kinases (jak)
Inventor: UNWALLA RAYOMAND JAL
IPC: C07D519/00
Filed: 2014-02-11
Abstract: The present invention provides pharmaceutically active pyrrolo{ 2,3-d} pyrimidine compounds. Such compounds are useful for inhibiting Janus Kinase (JAK). The invention is also directed to compositions comprising the compositions of the invention and uses of the compositions in the treatment or prevention of disorders or conditions mediated by JAK. In particular, the present invention provides a compound of formula IA or a pharmaceutically acceptable salt thereof, wherein Y is –A-R5, where A is a bond, --(CH2)k-- or --(CD2)k-- and R5 is C1-C6 linear or branched chain alkyl, C3-C6 cycloalkyl, aryl, or --NRa’Rb’, or is an unsaturated, saturated or partially saturated monocyclic or bicyclic ring structure containing a total of five to eleven atoms having one to three heteroatoms independently selected from the group consisting of oxygen, nitrogen, and sulfur, wherein said alkyl, C3-C6 cycloalkyl, aryl, or monocyclic or bicyclic ring structure is further optionally substituted with one or more substituents selected from the group consisting of deuterium, halo, C1-C6 linear or branched chain alkyl, CN, hydroxyl, CF3, --ORe, --NReRf, --S(O)pRe and C3-C6 cycloalkyl, where said alkyl and cycloalkyl may be optionally substituted with one or more substituents selected from the group consisting of halo, CN, hydroxyl, CONH2, and SO2CH3, where (a) Ra’ and Rb’ are independently hydrogen, deuterium, C1-C6 linear or branched chain alkyl, C3-C6 cycloalkyl, aryl, (C1-C6 linear or branched chain alkyl)aryl, heteroaryl, or (C1-C6 linear or branched chain alkyl)heteroaryl, where said alkyl and cycloalkyl may be optionally substituted with one or more Rc’, or (b) Ra’ and Rb’ together form a chain comprising -–(CRc’Rd’)j--, where Rc’ and Rd’ are independently hydrogen, deuterium, C1-C6 linear or branched chain alkyl, aryl, (C1-C6 linear or branched chain alkyl)aryl, heteroaryl, (C1-C6 linear or branched chain alkyl)heteroaryl, halo, CN, hydroxyl, CF3, CONH2, --ORe, --NReRf, or --S(O)pRe; where Re and Rf are independently hydrogen, deuterium, C1-C6 linear or branched chain alkyl, or C3-C6 cycloalkyl, where said alkyl and cycloalkyl may be optionally substituted with one or more substituents selected from the group consisting of halo, CN, hydroxyl, CF3, and CONH2; j is 2, 3, 4 or 5; k is 1, 2, 3, or 4; and p is 0, 1 or 2.
Patent NZ-710980-A (NZ)
Title: Clarification and selective binding of phenolic compounds from liquid foodstuff or beverages using smart polymers
Inventor: SILVA SANTOS LEONARDO
IPC: C12H1/14
Filed: 2014-02-24
Abstract: The present invention corresponds to a method for the removal of unwanted phenolic compounds from beverages. The method comprising contacting a selected polymer with the beverage. In a particular embodiment, the polymers are selected among polyaniline (PAÑI), polyaniline emeraldine base (PANI-EB) and polyaniline emeraldine salt (PANI-ES) polymers, or the polymers are selected among polyamidoamine (PAMAM) dendrimers functionalized with polyaniline (PAÑI), polyaniline emeraldine base (PANI-EB) and polyaniline emeraldine salt (PANI-ES) polymers.
Patent NZ-716647-A (NZ)
Title: Neurodegenerative disorders
Inventor: GREENFIELD SUSAN
IPC: C07K7/64
Filed: 2014-07-04
Abstract: A cyclic polypeptide, derivative or analogue thereof, comprising an amino acid sequence derived from the C-terminus of acetylcholinesterase (ACh E), or a truncation thereof.
Patent NZ-719041-A (NZ)
Title: Bottom and side gusseted package and method
Inventor: YEAGER JAMES W
IPC: B31B50/10
Filed: 2014-10-09
Abstract: A method of making gusseted packages disclosed herein at least addresses the problems associated with the limited height of a package in the conventional forming of a bottom-gusseted package. The bottom and side gusseted package formed in accordance with the method disclosed herein comprises a package body, a pair of inwardly extending side gussets, and a pair of bottom gussets positioned transversely of a longitudinal axis of the package body. Formation of the gusseted package is effected by positioning individual sleeves transversely of the longitudinal axis of a flexible web which forms the package body. During package formation, the inwardly extending side gussets are formed, and the flexible web is cut to form individual packages, such that the individual sleeves form a pair bottom gussets in a respective one of the gusseted packages, with the side gussets configured to extend between the pair of bottom gussets of the package. The bottom and side gusseted package formed in accordance with the method disclosed herein therefore at least allows for a bottom and side gusseted package of any selected height to be readily and efficiently formed.
Patent NZ-728437-A (NZ)
Title: Methods for increasing cas9-mediated engineering efficiency
Inventor: CAMERON PETER SEAN
IPC: C12N15/11
Filed: 2015-08-26
Abstract: Methods for use with Type II CRISPR-Cas9 systems for increasing Cas9-mediated genome engineering efficiency are disclosed. The present invention provides a method for reducing binding and/or cleavage of an off-target nucleic acid by a complex comprising a catalytically active Cas9 protein and a guide polynucleotide, the method comprising: (a) contacting a first complex with a selected target nucleic acid, wherein the first complex comprises: (i) a catalytically active Cas9 protein, and (ii) a first guide polynucleotide that comprises a spacer adapted to bind to the selected target nucleic acid; and (b) contacting a second complex with an off-target nucleic acid, wherein the second complex comprises (i) a catalytically inactive Cas9 protein (dCas9 protein) that does not cleave the off-target nucleic acid, and (ii) a second guide polynucleotide that comprises a spacer adapted to bind to the off-target nucleic acid, thereby reducing binding and/or cleavage by the first complex of the off-target nucleic acid. The method can be used to decrease the number of off-target nucleic acid double-stranded breaks and/or to enhance homology-directed repair of a cleaved target nucleic acid.
Patent NZ-732073-A (NZ)
Title: Soluble universal adcc-enhancing synthetic fusion gene and peptide technology and its use thereof
Inventor: LI CHIANG
IPC: C07K14/735
Filed: 2015-12-08
Abstract: Novel synthetic biology -based ADCC technologies are provided that enhance or enable ADCC responses, for example, through a rationally-designed soluble universal ADCC enhancer protein (SUAEP) where a high-affinity CD3 -binding domain is fused to a high-affinity Fc-binding domain. The SUAEP technology can be used to prevent or treat cancers, infectious, inflammatory or autoimmune diseases, and other diseases where elimination of diseased cells is desirable.
Patent NZ-734614-A (NZ)
Title: Diffuse acoustic confocal imager
Inventor: HERRING RODNEY
IPC: A61B8/12
Filed: 2016-01-11
Abstract: A diffuse acoustic confocal imager device for use with a data analyzer for providing three dimensional and state information of a second (internal) object within a first object based on an amplitude and phase information of a detected scattered beam, the device comprising: a coherent acoustic source configured to produce an acoustic coherent beam ranging from 0.5 megahertz to 100 megahertz; an acoustic coherent beam focuser configured to focus the acoustic coherent beam to a virtual source on the surfaces and inside the first object such that the virtual source emits a plurality of diffusely scattered beams; means for scanning the virtual source outside and inside the first object; a two-dimensional acoustic detector with a synthetic temporal aperture, the two-dimensional acoustic detector configured to detect at least one scattered beam from the virtual source after the scattered beam/s passes through the second object; and a vector network analyzer, to measure the amplitude and phase of the acoustic coherent beam and the at least one detected scattered beam to provide an amplitude and phase image of the second object, the vector network analyzer in electronic communication with each of the coherent acoustic source and the acoustic detector.
Patent NZ-735575-A (NZ)
Title: Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
Inventor: PYUN HYUNG-JUNG
IPC: C07D498/14
Filed: 2016-04-01
Abstract: Compounds for use in the treatment of human immunodeficiency (HIV) infection are disclosed. The compounds have the following Formula (la): including stereoisomers and pharmaceutically acceptable salts thereof, wherein A, A’, R1 and R2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Patent NZ-736139-A (NZ)
Title: Multi-use blood control safety catheter assembly
Inventor: HARDING WESTON
IPC: A61M39/26
Filed: 2016-04-15
Abstract: A valve actuator that moves in a catheter assembly between a first position where a valve is closed and a second position where the valve is open, the valve actuator including a shaft portion at a distal end of the valve actuator that is configured to pierce the valve, a mating portion at a proximal end of the valve actuator that is configured to engage a Luer device, a diameter reduction region that connects the shaft portion and the mating portion, and a plurality of windows that radially extend through the valve actuator for flushing fluid, the plurality of windows being disposed in the diameter reduction region, wherein each of the plurality of windows does not extend a full length of the diameter reduction region, and each of the plurality of windows being elongated in a circumferential direction. Increasing the length of the windows increases the velocity of saline flow and improve flushing performance.
Patent NZ-736169-A (NZ)
Title: Processes for enhancing saccharification of biomass materials
Inventor: MEDOFF MARSHALL
IPC: C13K1/02
Filed: 2013-07-01
Abstract: A method for enhancing saccharification comprising: providing a saccharified mixture from a saccharifying process and separating a first cellulase solution from a solid component of the saccharified mixture, said first cellulase solution comprising enzymes and sugars; saccharifying a first biomass using the first cellulase solution, thereby producing a second biomass and a first sugar solution; separating the second biomass from the first liquid solution, the first sugar solution enriched in sugars compared to the first cellulase solution: saccharifying the second biomass using a second cellulase solution, the second cellulase solution comprising cellobiase, thereby producing a third biomass and a second sugar solution; and separating the third biomass from the second sugar solution to obtain a second cellulase solution comprising enzymes and sugars.