Patent SG-11201907427Y-A (SG)
Title: Engineered transferrin receptor binding polypeptides
Inventor: CHEN XIAOCHENG
IPC: A61K39/00
Filed: 2018-02-15
Abstract: PUBLISHEDUNDER THE PATENT COOPERATION TREATY (PCT) 0 0111 °nolo moncill mum° oimIE (10) International Publication Number WO 2018/152326 Al WIPO I PCT (12) INTERNATIONAL APPLICATION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 23 August 2018 (23.08.2018) (51) International Patent Classification: C07K 14/79 (2006.01) A61K 39/00 (2006.01) C07K 14/705 (2006.01) A61K 38/40 (2006.01) (21) International Application Number: PCT/US2018/018371 (22) International Filing Date: 15 February 2018 (15.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). 62/460,692 17 February 2017 (17.02.2017) US Published: 62/543,658 10 August 2017 (10.08.2017) US with international search report (Art. 21(3)) 62/583,314 08 November 2017 (08.11.2017) US with sequence listing part of description (Rule 5.2(a)) (71) Applicant: DENALI THERAPEUTICS INC. [US/US]; 151 Oyster Point Blvd., 2nd Floor, South San Francisco, California 94080 (US). (72) Inventors: CHEN, Xiaocheng; c/o Denali Therapeutics Inc., 151 Oyster Point Blvd., 2nd Floor, South San Fran- cisco, California 94080 (US). DENNIS, Mark S.; c/o De- nali Therapeutics Inc., 151 Oyster Point Blvd., 2nd Floor, South San Francisco, California 94080 (US). KARIOLIS, Mihalis; c/o Denali Therapeutics Inc., 151 Oyster Point Blvd., 2nd Floor, South San Francisco, California 94080 (US). SILVERMAN, Adam P.; c/o Denali Therapeutics Inc., 151 Oyster Point Blvd., 2nd Floor, South San Fran- cisco, California 94080 (US). SRIVASTAVA, Ankita; c/ o Denali Therapeutics Inc., 151 Oyster Point Blvd., 2nd Floor, South San Francisco, California 94080 (US). WAT- TS, Ryan J.; c/o Denali Therapeutics Inc., 151 Oyster Point Blvd., 2nd Floor, South San Francisco, California 94080 (US). WELLS, Robert C.; c/o Denali Therapeutics Inc., 151 Oyster Point Blvd., 2nd Floor, South San Francisco, California 94080 (US). ZUCHERO, Joy Yu; c/o Denali Therapeutics Inc., 151 Oyster Point Blvd., 2nd Floor, South San Francisco, California 94080 (US). (74) Agent: HAO, Joe C. et al.; Kilpatrick Townsend & Stock- ton LLP, Mailstop: IP Docketing - 22, 1100 Peachtree Street - Suite 2800, Atlanta, Georgia 30309 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 1-1 O \" (57) : Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and 0 methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell. (54) Title: ENGINEERED TRANSFERRIN RECEPTOR BINDING POLYPEPTIDES