baber/WOPTO huggingface dataset:
Patent EC-SP13013033-A (EC)
Title: Derivados de 2-(2,4,5-anilino sustituido)pirimidina como moduladores de egfr útiles para el tratamiento del cáncer
Inventor: WARD RICHARD ANDREW
IPC: C07D471/04
Filed: 2013-11-19
Abstract: La presente invención se refiere a ciertos compuestos de 2-(2,4,5-anilino sustituido)pirimidina y sales farmacéuticamente aceptables de los mismos que pueden ser útiles en el tratamiento o prevención de una enfermedad o afección médica mediada por ciertas formas mutadas de receptor del factor de crecimiento epidérmico (por ejemplo el mutante activante L858R, el mutante activante de la supresión Exon19 y el mutante de resistencia T790M). Tales compuestos y sales de los mismos pueden ser útiles en el tratamiento o prevención de un número de diferentes cánceres. La invención también se refiere a composiciones farmacéuticas que comprenden dichos compuestos y sales de los mismos, especialmente formas polimórficas útiles de estos compuestos y sales, a intermedios útiles en la fabricación de dichos compuestos, y a métodos de tratamiento de enfermedades mediadas por diversas formas diferentes de EGFR usando dichos compuestos y sales de los mismos.
Patent EE-200100660-A (EE)
Inventor: DIETRICH RANGO
IPC: A61K9/10
Filed: 2000-05-31
Abstract: Novel administration forms and preparations for acid-labile active compounds are described. The novel administration forms contain individual active compound units, the active compound being present in the active compound units in a matrix made of a mixture comprising at least one fatty alcohol. In particular, the active compound units are microspheres which can be produced by prilling.
Patent EE-200300012-A (EE)
Inventor: BERGSTEN ANDERS
IPC: H04L47/20
Filed: 2001-06-21
Abstract: Arrangement for realization of virtual shared medium for QoS in a communication network, at which a network unit (6) has an input port (1) and an output port (7) for two-way communication in a session, where each port (1, 7) includes a metering device (3, 10) arranged to meter data transmission speed, and an action device (4, 9), from a communication point of view connected to respective metering device (3, 10), and arranged to take/execute actions depending on the belonging metering device. The metering device (3) in said input port (1) is adapted to metering of data flows belonging to a first service, and the metering device (10) in said ouput port (7) is adapted to metering of data flows belonging to the same service, at which said output port (7) includes a calculation device ( SIGMA >0<) arranged to calculate control data depending on the metering device (3) in said input port (1) and the metering device (10) in said output port, and that the action device (9) in said output port (7) is arranged to, for said service, take/execute actions on the flow belonging to the service depending on said control data. Said control data is preferably the sum of data transmission speed of/for said service, metered by said metering device (3, 10) in said input port (1) and output port (7).
Patent GB-189711530-A (GB)
Title: Improvements in Weather Proof Metal Linkage and similar Joints.
Inventor: CROWDEN CHARLES THOMAS
Filed: 1897-05-08
Granted: 1898-04-09
Abstract: 11,530. Crowden, C. T. May 8. Motor road vehicles. -Consists of weather-proof linkage and similar joints, more especially adapted for use in the steering-gear of self-propelled vehicles. The preferably conical pin A carried by one member of the joint fits into a socket in the other as shown, and is held in place by a pin and collar A<5>. Leather washers are inserted at B<2>, B<3>. The joint is enclosed by a cap C fitting over or screwed on to the socket piece. The pin may be recessed and may have ducts in it for lubrication. The Specification also shows similar joints with two pins at right-angles to each other.
Patent GB-189715349-A (GB)
Title: Improvements in Pneumatic Tyres.
Inventor: WILLIG JOSEPH
Filed: 1897-06-26
Granted: 1897-07-31
Abstract: 15,349. Willig, J. June 26. Tyres, pneumatic, preventing puncture of. A protective cover C for the air tube of a pneumatic tyre consists of two layers of leather formed from a single strip, the bevelled edges c<2> of which are cemented together. A central metal strip F is placed between the two layers of leather, and steel wires E for securing the tyre to the wheel rim are inserted in the edges of the protective strip. The metal strip F and steel wires E are secured in position by threads g and.g<1> respectively, and the two leather layers and metal strip are cemented to one another. In a modified form, the edges of the metal strip F are provided with metal guards f to prevent the metal strip from cutting the threads g.
Patent GB-189723151-A (GB)
Title: Improvements in Oil Lamps and Oil Stoves.
Inventor: THORPE ALFRED
Filed: 1897-10-08
Granted: 1897-11-13
Abstract: 23,151. Thorpe, A. Oct. 8. Oil stoves; reservoirs.-To facilitate the filling of the reservoirs a rotatable valve or closing-piece c is pivoted to the filling-nozzle b<2> by an eyelet d, through which passes the stem d<1> of the float for indicating the level of the oil in the reservoir. Similarly-shaped openings b<3>, c<1> are cut in the nozzle b<2> and in the valve c. When these openings coincide the reservoir may be filled ; at other times the valve c is turned so that an uncut portion of the valve closes the openings b<3> in the nozzle.
Patent GB-189723716-A (GB)
Title: Improvements applicable to Music, Books, and the like, to Facilitate the Turning of the Leaves thereof.
Inventor: CARDOZO HERBERT GEORGE
Filed: 1897-10-14
Granted: 1898-08-27
Abstract: 23,716. Cardozo, H. G. Oct. 14. Music leaves modified to facilitate turning.-The leaves of music or other books are provided with tabs to enable them to be readily turned. The tabs consist in some cases of paper or other fabric, folded and cemented to the edge of the leaf so that they can be folded in when not required. Fig. 8 shows another form, in which the tab a slides through a guide f secured to the leaf. It may also slide through a slit cut in the leaf. In another form the tab is first cut out, as shown in Fig. 11, and is then folded along the dotted line. It is then applied to the leaf, as shown in Fig. 9, so that the leaf lies between the fold, and it turns on a pivot g so that it can assume either of the positions shown in full and dotted lines respectively. The tabs are placed one above the other so as to enable them to be readily handled.
Patent GB-189724539-A (GB)
Title: Improvements in Making Photographic or other Portraits stand out in Bas Relief.
Inventor: PRESTWICH WILLIAM HENRY
Filed: 1897-10-23
Granted: 1898-08-27
Abstract: 24,539. Prestwich, W. H. Oct. 23. Embossing photographs.-An intaglio is produced by carving or engraving the photograph or other picture to be embossed in a block of wood or plaster of Paris. Three holes are made in the margins of the intaglio for the reception of pins, to secure correct register in subsequent operations. A reversed outline of the picture is drawn on a sheet of cardboard by means of tracing-paper and carbon paper. The piece of cardboard enclosed by this outline is then cut out. A relief block or die is now made by placing the cardboard in correct register on the intaglio, and filling up to the level of the cardboard with plaster of Paris. A card or wood block E, Fig. 4, is then glued on the back of the relief block D, and it is placed in a frame F. Over this is placed the photograph M to be embossed, over this the cut-out cardboard. C, over this a thick sheet of india-rubber T, and finally over this a block of wood W. The pins p fitting in holes P keep everything in register. An upper frame G clamped by three screws S on the frame F holds the margins of the photograph. The embossing-pressure is then applied in the direction of the arrows H.
Patent GB-189730218-A (GB)
Title: An Improved Universal or Ball Joint.
Inventor: RICHTER FELIX
Filed: 1897-12-21
Granted: 1898-01-29
Abstract: 30,218. Richter, F. Dec. 21. Ball-and-socket joints.-A ball g is mounted, so as to be free to rotate, on the rod f and is embraced by a frame a, a', c, c' secured to the rod h. The sides a, a<1> of the frame are formed with apertures to fit the ball, while the others c, c<1> are provided with bearing-rings b, b<1>. The frame is adjustable in the manner indicated. The ball may be made in two halves, one provided with a circular boss and the other with a corresponding recess, and fixed together by screws.
Patent GB-189808830-A (GB)
Title: Improvements in Tool Holders for Metal Working Machines.
Inventor: DAHL JOACHIM JOHANNES
Filed: 1898-04-15
Granted: 1898-11-19
Abstract: 8830. Dahl, J. J. April 15. Planing; toolholders. - A toolholderforaplaning or other metalworking machine has a revoluble sleeve in which the tool is fixed, the sleeve being rotated through 180‹ at the end of each stroke, so that the tool cuts during both backward and forward strokes. As applied to a planing-machine, the casing a is secured in the usual way to the slide-rest A, and has a sleeve b held by nuts b<1>. A bevel-wheel b<3> on the sleeve gears with a toothed segment i attached to a drum k and rotating on a pin h. The sleeve is locked in one of two positions by a spring pin c engaging notches b<4>. The pin is disengaged by a lever c', pivoted at c<2>, and operated by a cam on the drum. A second sleeve d is held in an oval hole in the sleeve b by bolts f, and can be adjusted laterally by a screw g so that the tool cuts uniformly in both directions. The tool e, e' is held in a tool-box d<2> pivoted to the sleeve d at d<1>. On rotating the drum at the end of a stroke, the pin c is first disengaged, the sleeve b being rotated 180‹, when it is again locked. The drum is rotated by an endless cord m, m<1> passing over guide-pulleys l and attached at p<1> to the belt fork q. A tension weight l<1> is hung on the cord. The belt fork is shifted in the usual way or by hand.
Patent GB-189809607-A (GB)
Title: Improved Electric Arc Lamp.
Inventor: TSCHIERET JOSEPH THIERAUT
Filed: 1898-04-26
Granted: 1899-03-04
Abstract: 9607. Tschieret, J. T. April 26. Arc lamps.- A clutch lamp is constructed as shown. The upper carbon is carried by a tube e, which slides in a sleeve g and on a rod f, secured to the frame a, b, c. A clutch r, bored to slide freely on the tube e, carries the core q of a shunt solenoid, and is supported near the core by a spring s. Feeding is effected by the core and clutch beingdrawn down, until the clutch rests on the sleeve g and frees the tube e. An adjustable screw u limits the upward movement of the clutch. The lower carbon is carried by a tube i, which slides through an insulating-sleeve m, and is hung by a cord j passed over pulleys to the tube e.
Patent GB-189809719-A (GB)
Title: An Improved Billiard Cue.
Inventor: BALAJTHY BARNABAS VON
Filed: 1898-04-27
Granted: 1898-06-11
Abstract: 9719. Balajthy, B. von. April 27. Billiards.-Cues are formed in two parts a, b, so that the centre of gravity shall be at x-x, namely, just below the joint. Between the two parts is a ring of elastic material c, and the upper surface of the butt end is slightly recessed as at e, f. The two parts are secured together by a rod d screwing into the end of the part b, p a s s i n g through a clearance hole in the other part, and held by a screwed nut and washer g.
Patent GB-189810580-A (GB)
Title: Improvements in Furnaces for Heating Metal Plates, Sheets, or Bars.
Inventor: ROSS FRANCIS EDWARD
Filed: 1898-05-09
Granted: 1899-03-25
Abstract: 10,580. Ross, F. E., and Gibson, A. J. May 9. Heating-furnaces for metals.-Fig. 7 shows a furnace for heating small articles. The flames and hot gases from the fireplace pass through apertures 7<a> to the combustion chamber 7 and flow as indicated by the arrows through cells 8 to the passage 12 and re-unite at the foot of the chimney 13. The articles are placed in the cells 8, each of which is in line with an opening 9 having a door 10 operated by a treadle 14. In a modification, suitable for plates, sheets, and bars, the cells 8 are charged at one end and discharged at the other through openings provided with hinged or other doors.
Patent GB-189812518-A (GB)
Title: Improvements in Driving Chains.
Inventor: TOMLINSON CHARLES EDWARD
Filed: 1898-06-03
Granted: 1898-12-10
Abstract: 12,518. Tomlinson, C. E. June 3. Locking b o l t s - Relates to driving- chains for cycles &c. The pin P, connecting the ends of a chain, has secured to it a spring arm S dished at S<1>, so that it may be sprung over the head of the rivet at the other end of the link, or it may have ears, to spring over the sides, or a central protuberance, to spring into a gap in the middle, of the link. Instead of being screwed into the side link, as shown, the pin may have a T-end and the link a slot to admit of the passage of the same.
Patent GB-189813289-A (GB)
Title: Improvements in the Manufacture of Organic Products from Sea-weed.
Inventor: KREFTING AXEL
Filed: 1898-06-14
Granted: 1898-07-16
Abstract: 13,289. Krefting, A. June 14. Seaweed, treating.-Seaweed is washed free from salts in a series of tanks with water to which at first limewater, calcium chloride or sulphate, or other suitable substance is added, to prevent solution of organic matter, and absorption of too much water by the seaweed. The washed seaweed is treated for some time with a weak cold solution of alkali or alkaline carbonate, which dissolves organic matter and is then further treated as described in Specification No. 11,538, A.D. 1896. Hypochlorites or other anti-putrefactive materials may be added to the washing-water and alkaline solution.
Patent GB-189816085-A (GB)
Title: Manual Compressing Machine for Compressing Hay Straw Fibrous and Bulky Material, and the like.
Inventor: BRANDON RICHARD
Filed: 1898-07-23
Granted: 1899-06-17
Abstract: 16,085. Brandon, R. July 23. Baling-presses.-Presses for hay, straw, and other fibrous and bulky materials comprise a platform A carrying two posts B which support a pulley D over which runs a cord f<1>, attached to the follower H at one end and at the other to a weight W and a drum F on the shaft E. Cords or chains j<2>, j<3>, j<4>, j<5> can be attached to hooks h<1>, h<2>, h<4>, h<5> on the edges of the follower, and are wound on to fusees J, J<1> by a handle k<3> acting through worm gearing K, k<1>. The worm-wheel K can be thrown out of gear with the shaft F, when the bale has been tied, by opening a clutch L by means of a lever N, and by unhooking the ropes j<4>, j<5> and pulling one of them the shaft is rotated, the cord f<1> wound on the drum F, and the follower lifted.
Patent GB-189821916-A (GB)
Title: Improvements in Holding or Supporting Sacks and Bags.
Inventor: SHACKEL RICHARD WILLIAM
Filed: 1898-10-18
Granted: 1899-09-16
Abstract: 21,916. Shackel, R. W. Oct. 18. Sack-holders. - Relates to a collapsable stand or frame for holding sacks to be filled. A pair of legs A, A are pivoted together near their middle, and are connected to a similar pair of legs by bars B. B. The legs are adjustably held in the open position by hinged bars C. The sack is held in the frame thus formed by spikes, clips, or the like. The legs A, A may be made extensible as shown at A' in Fig. 8. In a modification, a metal ring may be secured to the tops of the legs A, A, and the sack secured over the ring by spikes. Other modifications in details are also described.
Patent GB-189825227-A (GB)
Title: Improvements in Acetylene Gas Generators for Lamps and other Apparatus.
Inventor: THUBRON DAVID
Filed: 1898-11-30
Granted: 1899-10-28
Abstract: 25,227. Thubron, D. Nov. 30. Acetylene lamps. -In the h a n d lamp shown in Fig. 7, water from the chamber B<1> is supplied under the control of the tap t to the carbide in the removable container s. In buoy lights and floating lights for fishing &c. purposes, water is admitted to the carbide chamber through minute holes in the side of the chamber, the flow of water being controlled by the pressure of the gas. In larger apparatus, the movements of the gas holder A, Fig. 1, automatically actuates the valve J which controls the supply of water to the perforated tube K. The gas generated from the carbide in the removable container E ascends the pipe F, lifts the valve g, and passes by the saw cuts L<1> in the pipe L to the water trap M, the filtering-chamber N, and the supply pipe O. In a modification, the carbide container, in the form of a perforated tube, depends from the top of the gas holder A.
Patent GB-189902194-A (GB)
Title: Improved Non-refilling Device for Bottles and the like.
Inventor: WILSON WILLIAM
Filed: 1899-01-31
Granted: 1899-12-02
Abstract: 2194. Wilson, W. Jan. 31. Stoppers ; refilling, preventing. - One or more perforated screens C, each furnished with an inwardly-directed tube D, are fitted in the neck of the bottle &c., preferably resting on shoulders B. In the arrangement shown in Fig. 1, the mouth is closed by an ordinary cork or stopper; in Fig. 2, the stopper I is shown fixed to a rod H, which passes through the permanently-attached cap E, the neck being formed with an outlet F for the liquid. When the stopper is withdrawn, as in Fig. 1, or raised from its seat, as in Fig. 2, the contents can be poured out through the screen C, the air entering through the tube D. The outlet F may be protected by a perforated screen, and, instead of it serving also as an air inlet, the inlet may be formed on the opposite side of the neck. As an additional precaution, a loose valve G of parchment or fine silk may be placed over the tube D, so that, on an attempt at refilling, it becomes wetted, and closes the tube.
Patent GB-189912435-A (GB)
Title: Improvements in and relating to the Construction of Pulleys.
Inventor: BECKER NICOLAUS
Filed: 1899-06-14
Granted: 1899-08-05
Abstract: 12,435. Becker, N. June 14. Pulleys.-Each half of the pulley consists of two bow-spring frames b of metal and battens a, preferably of wood, screwed thereto and recessed to embrace the shaft. The rim may be of thin wood or of sheet metal covered with linoleum. The halves of the pulley are fixed together by bolts d and bars e, which fit over the chord members of the frames.
Patent GB-190006789-A (GB)
Title: Improvements in Knitting Machines.
Inventor: SOWTER GEORGE
Filed: 1900-04-11
Granted: 1901-03-23
Abstract: 6789. Sowter, G., and James, W. I. April 11. Circular knitting-machines.-Relates to a machine for knitting braids, laces, trimmings, and the like. The needles work in a rotating conical bed a, divided at a<1>, a<2> to enable the upper part a<3>, which has a hollow stem a<4>, to be raised or lowered by a screw a<5> to regulate the length of loop. The fixed cam shell has two sets of cams, which act on needles of differe it lengths, and carries preferably four fixed thread-guides c<1>, c<2>, &c. corresponding to the number of rises in the cams. The needle cylinder is driven by bevel gears e<3>, e<2> from the main shaft, having fast and loose pulleys e, e<1>. The work passes through the hollow stern a<4>, between a pair of rolls d, d' geared together and pressed together by springs, and winds on a reel g. The rolls d and reel g bear in a frame f, f<1>, depending from and rotating with the needle cylinder. The frame is hinged at j<1> to allow of the removal of the reel g. The rolls d are driven from a fixed pulley h by a pinion h<1> on a shaft having a worm engaging a worm-wheel on the shaft of one of the rolls. The reel is driven by a band and pulleys g', g'. The frame f, f<1> can be turned aside to disengage the worm gear, and so allow the rolls d to be turned by the hand-wheel d<4>. The thread reels are carried on tension bars k or on the stems k<2>. The threads pass upwards through eyes k<3> and over oiled pads in cases k<4>, then through eyes l<6>, and over a ring k<5> to the guides c', c<2>, &c. The eyes l<6> project upwards from pivoted levers l<4>, which are normally held, by the tension of the threads, in the position shown in dotted lines in Fig. 6. When a thread breaks or runs out, the corresponding lever l<4> drops, and a projection l<7> on its under side comes within range of an edge cam on the shaft l, which is thereby shogged lengthwise ; a cone on the shaft l then rocks a T lever m, and withdraws the end m<3> from a notch in a bar m<5>; the bar m<5> is then moved endwise by a spring, and so shifts the belt fork and stops the machine. The levers l<4> may all be raised, to facilitate the insertion of the threads, by moving endwise a bar m, having inclines which engage the levers l<4>, The machine may be stopped by operating the lever m and belt fork by handles m<9>, m<8>.
Patent GB-190006959-A (GB)
Inventor: BRYAN-HAYMES ROBERT
Filed: 1900-04-12
Granted: 1901-03-09
Abstract: 6959. Bryan-Haymes, R. April 12. Tyres, pneumatic etc.; felloes or rims.- The backwardlyturned edges a of the wheel rim b engage the inner edges k of two metallic side rings h, which may be held at their normal distance a part by transverse bolt, h<1>. The outer edges g of the rings h hook on to projections f formed on the edges of a thick rubber tread strip d. The strip d Las recesses or projections o, preferably shaped like broad-arrows, which prevent side slip, and it is shaped to support the shoulders p of the rings h in case the air tube c becomes punctured. In a modification, the strip d may be hollow, or filled with horsehair or cork.
Patent GB-190023867-A (GB)
Title: Improvements in and relating to Driving Mechanism for Velocipedes.
Inventor: HILL ARTHUR
Filed: 1900-12-31
Granted: 1901-12-14
Abstract: 23,867. Hill, A. Dec. 31. Manumotive cycles ; harcdle-bars ; driving - mechanism.- Relates to handdriving gear for the front wheels. On each side of the wheel hub there is secured a bevel-wheel E gearing with a bevel-wheel D secured on an axle Amounted on the forks and fitted with a drum B connected to it by a forwarddriving clutch. Cords F passing under the drums are led through eyes x on the forks, and their ends are secured on each side of the handle-bar G, which is arranged so as to rock on a pin G at the centre so as to drive the drums &c. In a modification, one set of bevel-wheels is dispensed with, both drums being mounted on one axle. In another arrangement, the cords are connected to arms formed perpendicular to the handlebars, which bars are arranged so as to rotate in a bearing formed on the handle-bar stem. The handle-bar stem may be fitted with rubber cushions or stops for the handle-bar, to prevent shock.
Patent GB-190101143-A (GB)
Title: Improvements in and connected with Oil Cooking Stoves.
Inventor: COLE HARRY
Filed: 1901-01-17
Granted: 1901-12-21
Abstract: 1143. Cole, H., Walter, A. H., and Lowe, H. Jan. 17. Oil cooking-stoves; trivets.-Relates to devices for use in connection with oil-cooking stoves so as to utilize the waste heat therefrom. The stoves such as A, usually have a hot chamber B at their upper part,openings C<1>, C' in the top upon which to place vessels, and a row of holes D for the escape of waste gases. The first device is an enclosure E, formed of ends e<1>, e', a bottom, and one side continued to form a top with a narrow groove e<3>. It is secured by bolts G passing through arms of the holes D. A grating F to carry saucepans &c. has flanges which rest on the top of the stove and within the groove. This device may be placed at the sides as well as at the back of the stove. The modification shown in Fig. 3 consists of a casing H forming a kind of hollow trivet. open at the front to receive heat from some of the holes D, and having a bottom, three sides, and a grating top. It is supported by means of two hooks I', P engaging in holes D, so as to be on or near the level of the top of the stove. The third device consists in supporting above the stove any cooking vessel or vessels, such as a removable oven and a removable boiler as shown in Fig. 8. The stove in this case is a large one, and has an extra top opening or openings J, above which is placed a grating K<1>. Over this is placed a jacketed oven L, having an opening l<4> at the top. Above this is another grating K', over which is supported a boiler M having open vertical tubes m<1> passing through it. Above these tubes is a third grating K<3> for supporting a pot &c. The oven and boiler may change places.