Patent SG-11201808693W-A (SG)
Title: Anti-il-33 antibodies, compositions, methods and uses thereof
Inventor: BLOOM LAIRD
IPC: C07K16/24
Filed: 2017-04-20
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 11111111111111111111111111111111111111111111111111111111111111111111111111 International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2017/187307 Al 02 November 2017 (02.11.2017) WIP0 I PCT (51) International Patent Classification: C07K 16/24 (2006.01) SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (21) International Application Number: PCT/IB2017/052282 (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (22) International Filing Date: 20 April 2017 (20.04.2017) GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (25) Filing Language: English EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (26) Publication Language: English MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (30) Priority Data: KM, ML, MR, NE, SN, TD, TG). 62/328,294 27 April 2016 (27.04.2016) US 62/483,781 10 April 2017 (10.04.2017) US Declarations under Rule 4.17: (71) Applicant: PFIZER INC. [US/US]; 235 East 42nd Street, — as to the identity of the inventor (Rule 4.17(i)) — as to applicant's entitlement to apply for and be granted a New York, New York 10017 (US). patent (Rule 4.17(0 (72) Inventors: BLOOM, Laird; 82 Falcon St., Needham, Massachusetts 02492 (US). NOCKA, Karl Henry; 84 — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Shaker Road, Harvard, Massachusetts 01451 (US). AP- Published: GAR, James Reasoner; 92 Cotton St., Newton, Massa- chusetts 02458 (US). FARMER, Mark A.; 8 Taylor Rd., — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the North Reading, Massachusetts 01864 (US). LAMBERT, Matthew Allister; 13 Gainsborough Court, Malahide, Dublin (IE). claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with (an) indication(s) in relation to deposited biological = (74) Agent: WALDRON, Roy F.; Pfizer Inc., 235 East 42nd Street, MS 235/9/S20, New York, NY 10017 (US). material furnished under Rule 13bis separately from the description (Rules 13bis.4(d)(i) and 48.2 (a)(viii)) Designated States (unless otherwise indicated, for every — with sequence listing part of description (Rule 5.2(a)) = (81) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, _ DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, _ = _ = = = Title: ANTI-IL-33 ANTIBODIES, COMPOSITIONS, METHODS AND USES THEREOF (57) : The invention provides antibodies, and anti- gen-binding fragments thereof, that specifically bind to IL-33, as well as uses, and associated methods thereof. = (54) = = 17 17 IL33mm2 — 14 - .4 IN VS 1 Sk A i )1.33WT DTI' e B © en ; 5 f IL-1alpha, IL-1beta, I L-33WT, !L- 36alpha, IL-36 gamma, rhIL18 IN , GC 11 350 400 4S0 500 550 600 IN Time 3 Il 0 FIG. 3A N O