baber/WOPTO huggingface dataset:
Patent NZ-538426-A (NZ)
Title: Pyrazole compositions useful as inhibitors of glycogen synthase kinase-3 (GSK-3)
Inventor: FORSTER CORNELIA J
IPC: A61P25/16
Filed: 2003-07-31
Abstract: A compound of formula (I) or a pharmaceutically acceptable derivative thereof is disclosed, wherein the variables are as defined in the specification. These compounds are inhibitors of protein kinases, particularly inhibitors of GSK3 mammalian protein kinase. Pharmaceutically acceptable compositions comprising these compounds and methods of utilizing those compounds and compositions in the treatment of various protein kinase mediated disorders are also described.
Patent NZ-541846-A (NZ)
Title: Vitamin receptor binding drug delivery conjugates
Inventor: VLAHOV IONTCHO RADOSLAVOV
IPC: A61K39/395
Filed: 2004-01-27
Abstract: The disclosure relates to a vitamin receptor binding drug delivery conjugate, and preparations thereof. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety is a vitamin, or a vitamin receptor binding analog or a derivative thereof, and the drug includes analogs or derivatives thereof. The vitamin receptor binding moiety is covalently linked to the bivalent linker, and the drug, or the analog or the derivative thereof, is covalently linked to the bivalent linker, wherein the bivalent linker (L) comprises one or more spacer linkers, releasable linkers, and heteroatom linkers. Methods and pharmaceutical compositions for eliminating pathogenic cell populations using the drug delivery conjugate are also described.
Patent NZ-545537-A (NZ)
Title: Capsaicin derivates and the production and use thereof
Inventor: HELSING TORSTEN
IPC: C07C233/22
Filed: 2004-09-10
Abstract: Disclosed is a compound of general formula (1) wherein R is disclosed within the specification. Also disclosed is a method of making the compound of formula (1) and the use of a compound of formula (1) for the production of paints or coatings.
Patent NZ-548749-A (NZ)
Title: Recreational apparatus
Inventor: STEPHENSON CLIVE BYRON
Filed: 2006-07-26
Abstract: The recreational jump apparatus has support cables strung between rims of a void and a loading station located at a first rim. A cable car travels on at least two of the cables distal from the load to a docking station. A node is located on the support cables between the docking station and the second rim. Swing ropes extend from the docking station over sheaves on the node to tethered ends for a jumper. Means are provided for returning the jumper to the docking station which still tethered to the jumper.
Patent NZ-549587-A (NZ)
Title: Device for nitriding by ionic implantation of an aluminium alloy part, and corresponding method
Inventor: GUERNALEC FREDERIC
IPC: C23C8/36
Filed: 2005-02-02
Abstract: A process for treating an aluminium alloy part by ion implantation comprises providing an apparatus comprising a source delivering ions accelerated by an extraction voltage, and first adjusting means for adjusting an initial beam of ions emitted by the source into an implantation beam. The source is an electron cyclotron source producing multi-energy ions. The multi-energy ions are implanted in the part at a temperature below 120°C. The implantation of the multi -energy ions from the implantation beam is effected simultaneously at a depth controlled by the extraction voltage of the source.
Patent NZ-554949-A (NZ)
Title: Method and system for offset matching in trades such as interest rate swaps
Inventor: WEINGARD MARK ANDREW ARISTOTLE
Filed: 2007-05-03
Abstract: A computerised trading system for reducing risk generated by derivative trades in which traders input positions into the system comprises a matching engine for matching positions input from traders and unilaterally performing a set of first offset trades to match the identified position; and a hedging engine for performing a series of hedge trades on the offset trades by performing a series of at least two corresponding trades with a fixed settlement date in a FRA market.
Patent NZ-556773-A (NZ)
Title: Quinazoline derivatives for inhibiting cancer cell growth and method for the preparation thereof
Inventor: HAM YOUNG JIN
IPC: A61K31/517
Filed: 2005-12-20
Abstract: Disclosed is a quinazoline derivative of formula (I) or a pharmaceutically acceptable salt thereof: wherein, R2 is hydrogen or alkyl; R3 is alkyl or dialkylaminoalkyl; Y is -(CR11R12)-, phenyl or a thiophenyl; R4 is hydrogen, halogen, alkoxy, ethylsulfanyl, cyclopropylmethoxy, cyclopentyloxy or alkylamino; R5 is hydrogen or alkyl; n is an integer in the range of 1 to 4; p is 0 or 1; wherein heteroaryl is heteroaromatic or non-aromatic; and the remaining substituents are as defined herein. Also disclosed is a pharmaceutical composition which comprises a compound as defined above for inhibiting the growth of cancer cells. Further disclosed is the use of a compound or salt defined as defined above for the manufacture of a medicament for inhibiting the growth of cancer cells, wherein the medicament may also be formulated for use in combination with an anticancer agent (such as cell signal transduction inhibitors, mitosis inhibitors, alkylating agents, antimetabolites, antibiotics, growth factor inhibitors, cell cycle inhibitors, topoisomerase inhibitors, biological reaction modifiers, antihormonal agents and antiandrogens.
Patent NZ-564098-A (NZ)
Title: Anti-IGF1R antibody formulations
Inventor: KOHLE PARAG
IPC: C07K16/10
Filed: 2006-06-13
Abstract: Provided is a pharmaceutical formulation, at a pH of about 5.5, comprising: (a) about 20 mg/ml of an antibody or functional antigen-binding fragment thereof comprising a light chain immunoglobulin variable region comprising light chain complementarity determining regions comprising specified amino acid sequences; and comprising a heavy chain immunoglobulin variable region comprising heavy chain complementarity determining regions comprising specified amino acid sequences; (b) about 2.3 mg/ml of sodium acetate trihydrate; c) about 0.18 mg/ml of acetic acid; (d) about 70 mg/ml of sucrose; and (e) water. Further provided is use of the antibody for the manufacture of medicaments.
Patent NZ-572248-A (NZ)
Title: Antibodies binding to the extracellular domain of the receptor tyrosine kinase alk
Inventor: AUF DER MAUR ADRIAN
IPC: A61K39/00
Filed: 2007-04-27
Abstract: Disclosed is an antibody that binds a 16-amino acid epitope on human ALK protein which has at least 75% identity to the sequence GlyArgIleGlyArgProAspAsnProPheArgValAlaLeu GluTyr. The use in the treatment of cancer and tumours is also disclosed.
Patent NZ-576103-A (NZ)
Title: Indexable tangential cutting insert and rotary cutting tool
Inventor: SATRAN AMIR
IPC: B23C5/20
Filed: 2007-10-16
Abstract: An indexable tangential cutting insert that has an insert body (102) having a central axis around which the cutting insert has 180 degrees rotational symmetry, a top surface (110), a bottom surface, a peripheral side surface extending between the top and bottom surfaces, the peripheral side surface including a pair of opposing major side surfaces connecting to a pair of minor side surfaces, and an insert through bore (180) extending along the central axis and connecting the top (110) and bottom surfaces. First and second major cutting edges (122A and 122B) are formed at the intersection of the major side surfaces, with the top surface having a convex contour which extends between the major cutting edges (122A and 122B) and first (174A) and second minor cutting edges are each formed along a juncture between one side of a major side surface (116A) and an adjacent minor side surface (114A). The bottom surface has a base surface and an insert protrusion abutment surface formed on an insert protrusion which rises above the base surface, in a bottom view of the cutting insert. The insert protrusion is formed in a central portion of the bottom surface and is at least partially surrounded by the base surface. An insert recess is formed in the insert protrusion along the central axis and communicates with the insert through bore (180), the insert recess having a maximum width dimension that is larger than a minimum diameter of the insert through bore (180).
Patent NZ-578993-A (NZ)
Title: Self powered trailer mounted wood splitter
Inventor: BURDER DAVID ROBERT
IPC: B27L7/06
Filed: 2009-08-12
Abstract: A wood splitter including a support structure (12) integrated into a trailer. The splitter component (18) is actuated by a hydraulic cylinder (22) which is fixed at the upper end to the structure (12) and which has a lower ram end connected to the splitter component by an extension arm (28) which extends upward from the lower ram end to the splitter component so that the splitter is mounted in a raised position relative to the ram end. In response to the operation of the hydraulic cylinder the splitter moves in a path parallel to the path traced by the lower ram end. Activation of the splitter requires both hands of the operator to effect due to separate placement of hand controls requiring simultaneous activation.
Patent NZ-582188-A (NZ)
Title: Pharmaceutical compositions and methods of treating dry eye disorders
Inventor: BEALS CHANNING RODNEY
IPC: A61P27/02
Filed: 2008-07-04
Abstract: Disclosed is 3-{ (3R,4R)-4-methyl-[methyl-(7H-pyrorolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl} -3-oxo-propionitrile for the treatment 5 of dry eye.
Patent NZ-584362-A (NZ)
Title: Method for Forming Corrugated Board by applying adhesive to corrugated sheet material and holding the corrugated sheet with a planar sheet under pressure
Inventor: VAN BERLO PATRICK PETRUS ANTONIUS MARIA
IPC: B31F1/20
Filed: 2011-03-31
Abstract: A method of bonding a substantially planar sheet material 104 to a corrugated sheet material 100 both of which are porous using a continuous process, characterised by the steps of first applying a controlled amount of adhesive 104 to the apex contact portion 102 of the corrugated sheet material 100, and then holding the respective planar and corrugated sheets together at a specified pressure and for a specified pressing period so that a bond is formed between them.
Patent NZ-588711-A (NZ)
Title: C-17 homologated oleanolic acid derivatives for treating cancer
Inventor: JIANG XIN
IPC: A61K31/56
Filed: 2009-04-20
Abstract: This disclosure relate to oleanolic acid derivatives represented by the structural formula depicted herein, wherein the variables are as defined in the specification. Also disclosed are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions. These compounds are suitable for the treatment and prevention of diseases such as those associated with oxidative stress and inflammation, and are particularly suitable for treating cancer selected from carcinoma, sarcoma, lymphoma, leukemia, melanoma, mesothelioma, multiple myeloma, or seminoma; or for treating cancer selected from cancer of the bladder, blood, bone, brain, breast, central nervous system, colon, endometrium, esophagus, genitourinary tract, head, larynx, liver, lung, neck, ovary, pancreas, prostate, spleen, small intestine, large intestine, stomach, or testicle.
Patent NZ-592827-A (NZ)
Title: Methods of preparing quinoline derivatives
Inventor: WILSON JO ANN
IPC: C07D215/22
Filed: 2009-11-13
Abstract: 592827 Disclosed is a method of preparing a compound of formula i(1) or a pharmaceutically acceptable salt thereof, wherein: R1 and R2 join together with the nitrogen atom to which they are attached form a 6 membered heterocycloalkyl X1 is H, Br, Cl or F; X2 is H, Br, Cl or F; s is 2-6; n1 is 1-2; and n2 is 1-2. The method comprising: contacting the compound of formula h(1) with reactant z(1) or z(1a) to yield the compound of formula i (1). Also disclosed is the compound i(1) when made by the process. An example of a compound of formula (I) is cyclopropane-1,1-dicarboxylic acid { 3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-ylamino]phenyl} -amide (4-fluorophenyl)-amide
Patent NZ-593395-A (NZ)
Title: A tiltable fan assembly with a flexible hose running through the tilting mechanism
Inventor: DYSON JAMES
IPC: F04F5/16
Filed: 2010-02-18
Abstract: A fan assembly comprises means (64, 68) for creating an air flow and an air outlet (14) for emitting the air flow, the air outlet (14) being mounted on a stand (18) for conveying the air flow to the air outlet. The fan assembly comprises a tilt mechanism for tilting the air outlet relative to at least part of the stand. The tilt mechanism comprises a flexible hose(312) defining, at least in part, an air passage through the tilt mechanism.
Patent NZ-594404-A (NZ)
Title: Novel polymorphic forms of 3-(1-{ 3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl} -6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride salt and processes of manufacturing thereof
Inventor: BECKER AXEL
IPC: A61K31/506
Filed: 2009-12-04
Abstract: 594404 Disclosed herein are crystalline 3-(1-{ 3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl} -6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride solvates and anhydrate, excluding 3-(1-{ 3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl} -6-oxo-1,6-dihydropyridazin-3-yl)-benzonitrile hydrochloride monohydrate, characterised by XRD diffraction patterns. Additionally disclosed is the use of said solvates and anhydrate in the treatment of physiological and/or pathophysiological conditions associated with Met-kinases. Additionally disclosed is a recrystallisation process for the production of said solvates and anhyrate.
Patent NZ-594594-A (NZ)
Title: Malate salt of n-(4-{ [6,7-bis(methyloxy)quinolin-4-yl]oxy} phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer
Inventor: GALLAGHER WILLIAM P
IPC: A61K31/47
Filed: 2010-01-15
Abstract: 594594 Disclosed is N-(4-{ [6,7-bis(methoxy)quinolin-4-yl]oxy} phenyl)-N'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, malate salt. Also disclosed is a pharmaceutical composition comprising the N-(4-{ [6,7-bis(methyloxy)quinolin-4-yl]oxy} phenyl)-N'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, malate salt as defined above; and a pharmaceutically acceptable excipient, for the treatment of cancer, thyroid cancer or glioblastoma in a subject.
Patent NZ-595107-A (NZ)
Title: Suspended cable railway system with an embarking and disembarking area
Inventor: BECK MARKUS
IPC: B61B3/00
Filed: 2011-09-09
Abstract: A cable railway terminal system to allow passenger exchange with elastically mounted cable support rollers (6a) is disclosed. The cable railway has a main support structure (10) which guides vehicles (3) via a guide rail (4) when the vehicles have been decoupled from the cable (20) upon entering the terminal. Control tyres (51, 52 and 53) coupled to one other by a gearing mechanism provides deceleration, conveying and acceleration of the vehicle through the terminal whilst still separate from the cable. The drive of the control tyres is provided by the cable via a drive assembly linking the support roller to the control tyres. The support rollers which are mounted on a rigid fastened axle absorb vibration from the cable and reduce transference of vibration to the support structure.
Patent NZ-598366-A (NZ)
Title: Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives
Inventor: HAMM RAINER
IPC: C07D309/10
Filed: 2010-09-24
Abstract: 598366 The present idisclosure relates to processes for preparing a glucopyranosyl-substituted benzyl-benzene derivative of general formula III, wherein R1 denotes (R)-tetrahydrofuran-3-yl or (S)-tetrahydrofuran-3-yl; and R2 denotes trimethylsilyl; and R’ denotes hydrogen or C1-6-alkyl; The compound is produced by reacting the organometallic benzyl-benzene compound of the formula VI with a gluconolactone of general formula IV.
Patent NZ-600017-A (NZ)
Title: 5-hydroxypyrimidine-4-carboxamide derivative
Inventor: TSUJI TAKASHI
IPC: A61K31/506
Filed: 2010-10-20
Abstract: 600017 The present disclosure provides a 5-hydroxypyrimidine-4-carboxamide derivative compound represented by formula (1), which enhances the production of erythropoietin and wherein, R1: formula (lB), Compounds of the disclosure include: ({ [2-({ 1-[4’-(acetoxymethyl)biphenyl-4-yl]piperidin-4-yl} methyl)-5-hydroxy-6-methylpyrimidin-4-yl]carbonyl} amino)acetic acid, ({ [5-hydroxy-2-({ 1-[4’-(1-hydroxyethyl)biphenyl-4-yl]piperidin-4-yl} methyl)-6-methylpyrimidin-4-yl]carbonyl} amino)acetic acid, ({ [5-hydroxy-2-({ 1-[4’-(2-hydroxypropyl)biphenyl-4-yl]piperidin-4-yl} methyl)-6-methylpyrimidin-4-yl]carbonyl} amino)acetic acid, ({ [5-hydroxy-2-({ 1-[4’-(2-hydroxy-1,1-dimethylethyl)biphenyl-4-yl]piperidin-4-yl} methyl)-6-methylpyrimidin-4-yl]carbonyl} amino)acetic acid, ({ [2-({ 1-[4’-(dimethylcarbamoyl)biphenyl-4-yl]piperidin-4-yl} methyl)-5-hydroxy-6-methylpyrimidin-4-yl]carbonyl} amino)acetic acid, ({ [2-({ 1-[2’-fluoro-4’-(hydroxymethyl)biphenyl-4-yl]piperidin-4-yl} methyl)-5-hydroxy-6-methylpyrimidin-4-yl]carbonyl} amino)acetic acid, ({ [5-hydroxy-2-({ 1-[4’-(hydroxymethyl)-3’-isopropylbiphenyl-4-yl]piperidin-4-yl} methyl)-6-methylpyrimidin-4-yl]carbonyl} amino)acetic acid, And [({ 2-[(1-{ 5-[3-chloro-4-(hydroxymethyl)phenyl]pyridin-2-yl} piperidin-4-yl)methyl]-5-hydroxy-6-methylpyrimidin-4-yl} carbonyl)amino]acetic acid The diseases which these compounds may be used to treat include: Anemia, nephrogenic anemia, anemia of prematurity, anemia incidental to chronic diseases, anemia incidental to cancer chemotherapy, cancerous anemia, inflammation-associated anemia, or anemia incidental to congestive heart failure.
Patent NZ-600210-A (NZ)
Title: Substituted 4-aminocyclohexane derivatives
Inventor: NOLTE BERT
IPC: A61K31/404
Filed: 2009-03-25
Abstract: ABSTRACT - 600210 The disclosure relates to 4-aminocyclohexane derivatives represented by general formula (I), wherein the variables are as defined in the specification. Examples of the compound of formula (I) include: 1-(imino(1-methyl-1H-indol-2-yl)methyl)-N1,N1,N4,N4-tetramethyl-4-phenylcyclohexane-1,4- diamine bis(2-hydroxypropane-1,2,3-tricarboxylate); 1,4-bis(dimethylamino)-4-phenylcyclohexyl)(1-methyl-1H-indol-2-yl)methanone; N1,N1,N4,N4-tetramethyl-1,4-diphenylcyclohexane-1,4-diamine; The compounds of formula (I) in the form of a single stereoisomer or mixture thereof, the free compounds and/or their physiologically acceptable salts are used for the treatment of pain.
Patent NZ-601835-A (NZ)
Title: Rodenticidal compounds, composition including same and use thereof for controlling harmful rodents
Inventor: BESSE STEPHANE
IPC: A01N25/00
Filed: 2011-02-16
Abstract: Disclosed herein are 4-hydroxy-coumarin compounds of general formula (I), wherein the substituents are as defined within the specification, processes for their preparation, compositions comprising said compounds and uses as a rodenticidal agent thereof. Said compounds being particularly useful for combating rats, mice, field mice, common rats and/or any other rodent pests.
Patent NZ-602873-A (NZ)
Title: Systems for achieving and assisting in improved nutrition based healthfulness
Inventor: ROST STEPHANIE LYN
IPC: A23L33/00
Filed: 2009-08-28
Abstract: A method and a data processing apparatus for selecting a food product based on the food product’s health effect on a human being are disclosed. The data processing apparatus comprises (a) a data gathering device, b) a computer module for associating the first and the second food products with a metagroup, c) a computer module for calculating a first healthfulness data for the first food product; d) a computer module for calculating a second healthfulness data for the second food; (e) a computer module for comparing the first healthfulness data to the second healthfulness data via the processor of the data processing apparatus; and (f) a computer module for providing an outcome of the comparing step which is display on a presentation device of the data processing apparatus product. The data gathering device is substantially designed to (i) obtaining data about nutrients of a first food product, and (ii) obtaining data about nutrients of a second food product; The metagroup is determined based at least, in part, on: i) a similarity in nutrients among different food products, and ii) similarity in usage of different food products within context of a specific diet and the metagroup is associated with a specific healthfulness formula stored in a storage device of the data processing apparatus. The healthfulness formula is a linear combination of at least a plurality of the following data about nutrients of a food product: i) fat content, ii) sugar content, iii) sodium content, iv) energy, v) saturated fat, and vi) dietary fibre content. The first healthfulness data for the first food product is calculated based on the healthfulness formula of the metagroup via the processor of the data processing apparatus. The second healthfulness data for the second food product is calculated based on the healthfulness formula of the metagroup via the processor of the data processing apparatus. .
Patent NZ-620242-A (NZ)
Title: Influenza virus mutants and uses therefor
Inventor: BILSEL PAMUK
IPC: C12N15/33
Filed: 2012-06-21
Abstract: Disclosed is a recombinant influenza virus having a mutant M gene comprising SEQ ID NO:1, SEQ ID NO:2, or SEQ ID NO:3, and a method for propagating such viruses. The sequences are as defined in the specification.
Patent NZ-630410-A (NZ)
Title: Apparatus and method for determining a non-condensable gas parameter
Inventor: NASHTARA ISLAM
IPC: G01F15/08
Filed: 2014-09-08
Abstract: Disclosed is an apparatus (20) for determining a non-condensable gas parameter relating to the amount of non-condensable gas within a variable flow rate fluid flow containing both non-condensable gas and condensate. The apparatus (20) comprises a measurement tube (26), a flow sensor (32), a phase sensor (28) and a non-condensable gas determination unit (34). The measurement tube (26) is arranged to receive the fluid flow and is arranged such that the fluid flow through the measurement tube (26) comprises alternating sections of non-condensable gas (i.e. bubbles) and condensate (i.e. liquid drops). The flow sensor (32) is provided to generating a flow rate signal relating to the flow rate of the fluid flow in the measurement tube (26). The phase sensor (28) monitors over time the alternating sections of non-condensable gas and condensate flowing through the measurement tube (26) and generates a phase signal characteristic of the monitored sections indicating whether they comprise a liquid or a gas. The non-condensable gas determination unit (34) is configured to determine a non-condensable gas parameter relating to the amount of non-condensable gas in the fluid flow based on the flow rate signal and the phase signal.
Patent NZ-724815-A (NZ)
Title: Humanized antibodies that bind lgr5
Inventor: REYES CHRISTOPHER
IPC: C07K16/28
Filed: 2015-04-02
Abstract: Disclosed herein are humanized anti-LGR5 antibodies for the treatment of cancer. Antibodies disclosed herein may bind LGR5 without disrupting LGR5-RSPO1 binding or signaling, and may disrupt LGR5 signaling through Wnt that is independent of RSPO1. Also disclosed are heavy and light chain polypeptide sequences for the biding of LGR5, for example without disrupting LGR5-RSPO binding or signaling.