baber/WOPTO huggingface dataset:
Patent BR-112023001741-A2 (BR)
Title: Sistema de fixação destinado a fixar um cabo em um tubo
Inventor: Maxime VANNETZEL
IPC: E21B17/10
Filed: 2021-07-28
Abstract: SISTEMA DE FIXAÇÃO DESTINADO A FIXAR UM CABO EM UM TUBO. A presente invenção refere-se a sistema de fixação (1) destinado a fixar um cabo (5) em um tubo (2) para uma coluna tubular para aplicações de óleo & gás, energia ou armazenamento, o dito sistema de fixação (1) compreendendo: - um primeiro anel 12, configurado para ser suportado no tubo (2); - um segundo anel (13), configurado para ser suportado no tubo (2); - um corpo central (102), disposto e bloqueado em deslocamento relativo ao longo de um eixo longitudinal entre o primeiro anel (12) e o segundo anel (13), em que o sistema de fixação compreende ainda um mecanismo de fixação de cabo (9) tendo um alojamento externo (8) para fixar o cabo (5), o dito alojamento externo (8) tendo uma abertura (10) para receber através da dita abertura (10) o cabo (5) no alojamento externo (8), a dita abertura (10) do alojamento externo (8) sendo disposta em uma superfície externa (4) do sistema de fixação (1), a dita superfície externa (4) sendo girada para fora relativa a um alojamento interno do sistema de fixação, o dito alojamento interno sendo configurado para alojar o tubo (2).
Patent BR-112023002471-A2 (BR)
Title: Método implementado por computador, programa de computador e sistema de controle automatizado
Inventor: ANDREAS WOLLNY
IPC: B29C45/76
Filed: 2021-08-13
Abstract: MÉTODO IMPLEMENTADO POR COMPUTADOR, PROGRAMA DE COMPUTADOR E SISTEMA DE CONTROLE AUTOMATIZADO. É proposto um método implementado por computador para controlar e/ou monitorar pelo menos um processo de moldagem por injeção em pelo menos uma máquina de moldagem por injeção (110). O processo de moldagem por injeção é com base em uma pluralidade de parâmetros de processo. O método compreende as seguintes etapas: a) fornecer um conjunto de parâmetros de entrada por pelo menos uma unidade externa de processamento (118), que compreende pelo menos um modelo de simulação, parâmetros específicos de material e de máquina de moldagem por injeção; b) a unidade externa de processamento (118), simulando um processo de moldagem por injeção com base no conjunto de parâmetros de entrada e determinando pelo menos um parâmetro do processo previsto do processo de moldagem por injeção simulado aplicando um algoritmo de otimização; c) realizar pelo menos um processo de moldagem por injeção usando a máquina de moldagem por injeção (110) com base no parâmetro do processo previsto para gerar pelo menos uma peça de trabalho (114), determinar pelo menos uma propriedade da peça de trabalho gerada (114) e comparar a propriedade com um alvo de otimização e; d) determinar pelo menos um parâmetro do processo real do processo de moldagem por injeção e comparar o parâmetro do processo real e o parâmetro do processo previsto e adaptar o modelo de simulação com base na comparação.
Patent BR-112023004798-A2 (BR)
Title: Método e sistema para sinalização remota de um conjunto de fundo de poço compreendendo uma ou mais ferramentas de fundo de poço
Inventor: EUAN MURDOCH
IPC: E21B43/12
Filed: 2021-09-14
Abstract: MÉTODO E SISTEMA PARA SINALIZAÇÃO REMOTA DE UM CONJUNTO DE FUNDO DE POÇO COMPREENDENDO UMA OU MAIS FERRAMENTAS DE FUNDO DE POÇO.  Um método para sinalização remota de um conjunto de fundo de poço compreendendo uma ou mais ferramentas de fundo de poço inclui operar um mecanismo estrangulador configurado para controlar o fluxo de fluido de produção de poço para produzir uma primeira assinatura de pressão no fluxo de fluido, a primeira assinatura de pressão definindo um sinal de disparo para aquele ou mais ferramentas de fundo de poço do conjunto de fundo de poço. A primeira assinatura de pressão compreende pelo menos um primeiro sinal de pressão e um segundo sinal de pressão no fluxo de fluido de produção no conjunto de fundo de poço. Operar o mecanismo estrangulador para produzir uma segunda assinatura de pressão no fluxo de fluido de produção no conjunto de fundo de poço em um período de tempo predeterminado após a primeira assinatura de pressão, a segunda assinatura de pressão definindo um sinal de comando para iniciar a operação de uma ou mais ferramentas de fundo de poço predeterminadas do conjunto de fundo de poço.
Patent BR-112023016918-A2 (BR)
Title: Material derivado de microrganismo e métodos para produzir o mesmo
Inventor: TOUBIA DIDIER
IPC: A23J3/20
Filed: 2022-02-22
Abstract: é aqui divulgado um método para separar uma proteína de um microrganismo compreendendo uma parede celular. outras composições compreendendo uma primeira fração, uma segunda fração ou ambas, derivadas de um microrganismo compreendendo uma parede celular e compreendendo um teor de proteína entre 10% e 90% em peso da fração, também são divulgadas.
Patent BR-112023017586-A2 (BR)
Title: Condicionador de contentor flexível
Inventor: Daniel Joel Barry
IPC: B65G69/08
Filed: 2022-02-22
Abstract: condicionador de contentor flexível. uma montagem de condicionador de contentor flexível é apresentada neste documento. a montagem inclui uma montagem de estrutura que define uma área de condicionamento de contentor flexível. a montagem de estrutura inclui uma primeira estrutura carreadora com um primeiro aríete e uma segunda estrutura carreadora com um segundo aríete. uma primeira montagem de acionador inclui uma primeira extremidade fixada à primeira estrutura carreadora e uma segunda extremidade fixada à segunda estrutura carreadora. uma segunda montagem de acionador inclui uma primeira extremidade fixada à primeira estrutura carreadora e uma segunda extremidade fixada à segunda estrutura carreadora. uma unidade de controle é configurada para mover simultaneamente o primeiro aríete e o segundo aríete de forma linear um em direção ao outro para engatar um contentor flexível dentro da área de condicionamento de contentor flexível.
Patent BR-112023020859-A2 (BR)
Title: Muteínas de lipocalina específicas para fator de crescimento do tecido conjuntivo (ctgf)
Inventor: WURZENBERGER CLAUDIA
IPC: C07K14/435
Filed: 2022-04-08
Abstract: muteínas de lipocalina específicas para fator de crescimento do tecido conjuntivo (ctgf). a presente invenção refere-se a muteínas de lipocalina capazes de se ligar ao ctgf, bem como, proteínas de fusão que compreendem referidas muteínas, que são úteis para fins analíticos, diagnósticos ou terapêuticos, por exemplo, no tratamento de uma doença fibrótica, um câncer, uma doença autoimune ou uma doença infecciosa. a presente invenção refere-se também aos métodos de preparar as muteínas de lipocalina ou proteínas de fusão descritas aqui. a presente invenção refere-se ainda às moléculas de ácido nucleico que codificam tais muteínas de lipocalina ou proteínas de fusão. além disso, a presente invenção refere-se aos usos terapêuticos e/ou diagnósticos de tais muteínas de lipocalina ou proteínas de fusão, bem como, a composições que compreendem uma ou mais de tais muteínas de lipocalina ou proteínas de fusão.
Patent BR-122020005073-A2 (BR)
Title: Composto, composição farmacêutica e uso do composto
Inventor: KATHLEEN MCCARTHY
IPC: C07D471/08
Filed: 2018-08-03
Abstract: são descritos no presente documento compostos moduladores de splicing de molécula pequena que modulam o splicing de mrna, tal como pré-mrna, codificado por genes, e métodos de uso dos compostos moduladores de splicing de molécula pequena para modular o splicing e tratar doenças e condições.
Patent SK-6299-A3 (SK)
Title: Machine tool system
Inventor: WIEMERS KARL-HEINZ
IPC: B23Q1/62
Filed: 1997-03-22
Abstract: The invention relates to a novel machine tool system provided with selectively energizable magnets for selectively moving a support for a work piece clamping plate into a floating condition and for changing the disposition of the clamping plate relative to operating tools. The floating condition permits movement of the clamping plate substantially without frictional engagement between the clamping plate support and structure such as a machine bed on which the support is movably mounted.
Patent CZ-16996-A3 (CZ)
Title: Therapeutical preparations containing cyclosporin
Inventor: STUCHLIK MILAN RNDR
IPC: A61K9/48
Filed: 1996-01-18
Abstract: PCT No. PCT/GN97/00131 Sec. 371 Date Nov. 23, 1998 Sec. 102(e) Date Nov. 23, 1998 PCT Filed Jan. 17, 1997 PCT Pub. No. WO97/26003 PCT Pub. Date Jul. 24, 1997Therapeutical compositions comprising from 0.1 to 20% by weight of a cyclosporin and a vehicle comprising from 1 to 60% by weight of polyethers constituted by, preferably, substances like ethoxy diglycol or polyethylene glycols 300 to 600 and/or substances like preferably dimethyl isosorbide, dimethyl isoidide and dimethyl isomannide, and from 1 to 60% by weight of a mixture of glyceryl monoesters of C8-C22 fatty acids and hexaglyceryl to pentadecaglyceryl monoesters of C8-C22 fatty acids in a ratio of 1:2 to 1:6. The therapeutical compositions preferably additionally comprise further adjuvants like anti-oxidants, preserving agents and stabilizers, flavoring agents, thickening agents and diluents. The compositions for external use preferably additionally comprise lipoaminoacids.
Patent CZ-20138-A3 (CZ)
Inventor: KLAZAR LUDĚK
IPC: F25B39/02
Filed: 2013-01-03
Abstract: ﻿Předmětem vynálezu je způsob iniciace odtávání výparníků tepelných čerpadel odebírajících nízkopotenciální teplo ze vzduchu, s kompresorem, nejméně dvěma výměníky tepla a expanzním ventilem. Za provozu tepelného čerpadla se monitoruje časový průběh růstu námrazy na výparníku při vypařovacím tlaku, který je nižší než vypařovací tlak počátku vzniku námrazy (poN), a to tak, že se sleduje teplota (tex) okolního vzduchu a relativní vlhkosti (.fi.ex) okolního vzduchu, vypařovací teplota (to) média v okruhu tepelného čerpadla a povrchová teplota na výparníku, které určují odvlhčení (.DELTA.x) a změny entalpie (.DELTA.h) při sledované změně vzniku a růstu námrazy, jejichž poměr se průběžně vyhodnocuje jako součinitel (Kn) tvorby námrazy, a současně se sleduje chladicí výkon (Qo´) okruhu tepelného čerpadla, daný chladícím výkonem kompresoru, který je hnacím prvkem tepelného čerpadla, a který závisí na vypařovací teplotě (to) média v okruhu tepelného čerpadla a kondenzační teplotě (tk) v okruhu tepelného čerpadla, přičemž součin součinitele (Kn) tvorby námrazy a chladícího výkonu (Qo´) okruhu tepelného čerpadla se průběžně v předem určených časových intervalech sumarizuje a jakmile suma jeho hodnot, která odpovídá množství námrazy na výparníku, přesáhne předem danou mezní hodnotu, iniciuje se odtávání výparníku.
Patent CZ-30898-A3 (CZ)
Title: Benzenesulfonamide derivatives, process of their preparation and their use in therapy
Inventor: PURCELL THOMAS
IPC: C07C303/44
Filed: 1996-08-01
Abstract: Benzenesulphonamide compounds of general formula (I), wherein R1 is a hydrogen or halogen atom such as chlorine or fluorine, or a straight or branched C1-4 alkyl or C1-4 alkoxy group, each of R2, R3 and R4, which are the same or different, is a hydrogen atom or a straight, branched or cyclic C1-4 alkyl group, and R5 is a hydrogen atom or a C1-2 alkyl, C1-2 fluoroalkyl or C1-2 perfluoroalkyl group, in the form of enantiomers, diastereoisomers or mixtures thereof, including racemic mixtures, as well as pharmaceutically acceptable acid addition salts thereof, are provided for therapeutical use.
Patent CZ-39396-A3 (CZ)
Title: The use of substituted aryloxyalkyldiamines, the compounds per se, process of their preparation, pharmaceutical compositions based thereon and process of their preparation
Inventor: VAN LOMMEN GUY ROSALIA EUGENE
IPC: C07C279/30
Filed: 1994-08-12
Abstract: PCT No. PCT/EP94/02702 Sec. 371 Date Feb. 5, 1996 Sec. 102(e) Date Feb. 5, 1996 PCT Filed Aug. 12, 1994 PCT Pub. No. WO95/05366 PCT Pub. Date Feb. 23, 1995The present invention is concerned with compounds having the formula    <IMAGE>  (I)  the pharmaceutically acceptable acid addition salts thereof, and the stereochemically isomeric forms thereof, wherein R1 is hydrogen or C1-6alkyl; R2 is hydrogen or C1-6alkyl; R3 is C1-6alkyl, hydroxy, cyano, halo, C1-6alkyloxy, aryloxy, arylmethoxy, C2-6alkenyl, C2-6alkynyl, C1-6alkyl-S-, C1-6alkyl(S=O)-, C1-6alkylcarbonyl; R4 is hydrogen, halo, hydroxy, C1-6alkyl, or C1-6alkyloxy; or R3 and R4 taken together form a bivalent radical; R5 and R6 each independently are hydrogen, halo, hydroxy, C1-6alkyl, C1-6alkyloxy, aryloxy or arylmethoxy; R7 is hydrogen; Alk1 is C2-5alkanediyl; Alk2 is C2-15alkanediyl; Q is a heterocyclic ring containing at least one nitrogen atom or a radical of formula    <IMAGE>  (aa)  Pharmaceutical compositions, preparations and use as a medicine are described.
Patent CZ-57493-A3 (CZ)
Title: Method of treating individual plants, preparations used for carrying out said method and process for preparing such preparation
Inventor: TSUBOI SHIN-ICHI
IPC: A01G7/06
Filed: 1993-04-02
Abstract: The present invention relates to a process for the treatment of individual plants with solid shaped plant treatment agents which are introduced into the sap conduction paths of the plants, new solid shaped plant treatment agents and their production.
Patent CZ-88193-A3 (CZ)
Title: Mechanically reinforced web, process of its production, and apparatus for making the same
Inventor: KNISPEL EBERHARD
IPC: D04B39/00
Filed: 1993-05-12
Abstract: A process for producing a mechanically consolidated fabric sheet with attached yarns involves inserting barbed needles (53) for the yarn-free consolidation of areas the sheet and simultaneously inserting compound needles (51, 52) for forming stitches to attach the yarns (3, 84) at spaced locations. The stitches may be formed from stitching yarns (22) or from fibres of the shoot and the attached yarns may include both warps (3) and wefts (84). The yarn-free regions are generally greater than the regions with attached yarns and the former may have a pile on one or both faces. <IMAGE>
Patent SK-58993-A3 (SK)
Title: Package comprised of environmentally compatible material and containing compressed flexible articles
Inventor: MUCKENFUHS DELMAR R
IPC: B65D85/07
Filed: 1991-11-29
Abstract: A more environmentally compatible package (10) containing one or more stacks of compressed flexible articles (20). For products such as single use absorbent baby diapers, catamenial pads, incontinent briefs and the like, the degree of compression within the bag may be as much as 50 % or more when compared to the uncompressed thickness of the articles. In a particularly preferred embodiment, the bag totally encloses a stack of compressed flexible articles and exhibits a substantially rectilinear shape. The bag preferably includes an integral carrying device (71). The side panels (30 and 31) and the front and back panels (40, 41) of the bag are subject to tension imposed by the stack of compressed flexible articles. A line of weakness at least partially spanning a tensioned side panel of the bag is provided and functions as an opening device. The line of weakness is coated with a layer of reinforcing material preferably comprised of polyvinyl alcohol to prevent premature rupturing of the opening device. The opening device (17) allows the compressive forces acting upon the flexible articles contained in the bag to be at least partially released when the opening feature is activated by the end user. Partial separation or complete removal of a portion of the tensioned side panel (17) of the bag allows the coinciding portion of the stack of compressed articles to project in a fan-like array through the aperture thus created to permit easy one-at-a-time or multiple removal. Polyvinyl alcohol of the type used to reinforce the opening feature may, if desired, also be used as a sealant for assembling the bag and to provide additional support for the carrying device.
Patent SK-70997-A3 (SK)
Inventor: SUPUKA STANISLAV
IPC: A47F10/06
Filed: 1997-06-05
Abstract: Pozostáva zo zásobníka (1), na ktorom je upevnený
pravý pridržiavač (7) pomocou pravej osi (12) prichytenej
v pravom prednom čape (11) a v pravom zadnom
čape (20) a proti nemu ľavý pridžiavač (7a) upevnený
pomocou ľavej osi (12a) prichytenej v ľavom prednom
čape (11a) a v ľavom zadnom čape (20a), pričom sú
pridržiavače (7) a (7a) pružne spojené prednou a zadnou
pružinou (8) a (8a), pričom pod pridržiavačmi (7) a
(7a) je umiestnený podávač (2), ktorý je prichytený
pomocou osi podávača (14) cez drážky zásobníka (19)
a (19a) a cez drážky kulís (18) a (18a) v kulisách (3a) a
(3a), pričom kulisy (3) a (3) sú vzájomne spojené osou
kulís (17), pri ľavej kulise (3a) je upevnená ojnica (5),
ktorá je druhou stranou na kľuke s axiálnou vačkou (6)
umiestnenou na hnacej závitovke prevodovky (15), ktorá
je upevnená na nosníku (16), na prevodovke (15) je
upevnený motorček (4) a na nosníku (16) je upevnený
koncový spínač (10) a na zadnej stene zásobníka (1) je
umiestnený kontrolný spínač (9) s kontaktnom (9a).
Patent SK-94595-A3 (SK)
Title: Collapsible modular system
Inventor: TRUKSA PAVEL
IPC: B60P3/34
Filed: 1994-01-24
Abstract: Portable collapsible structures whose wall panels are directly coupled in an articulated manner to bottom and ceiling panels are known. The inconvenient of these constructions is that they offer few variation possibilities and are insufficiently rigid. It is proposed to rotatively mount at least one tipping wall (5) on at least one of the horizontal frames (1, 2). At least one connecting rod (7) is rotatively secured to the tipping wall (5), at a distance from the axis of rotation (6), whereas its opposite end is secured to the adjacent frame (2, 1), also in a rotative manner. The axis of rotation (6) of the tipping wall (5) extends in a parallel direction to the axes of journals (8, 9) of the connecting rod (7). The invention is useful for portable structures, camping cars and caravans.
Patent SK-94696-A3 (SK)
Title: Block copolymers, their preparation and use as lubricants
Inventor: FORLINI ALBERTO
IPC: C10M107/34
Filed: 1996-07-18
Abstract: Disclosed are three-block copolyethers of general formula (I), wherein the said symbols have the meanings in description. Disclosed is also the use of the said compound of general formula (I) for industrial gearing, differential gears and in oils for two-stroke engines, as well as modifying compositions for four- stroke engines and the preparation for lubricant oil of four-stroke engines, which contains this compound of general formula (I) in the amount from 5 to 50 wt. %.
Patent CZ-116992-A3 (CZ)
Title: device for inspection and maintenance work and the like on bridge soffits
Inventor: JUNGER HANS
IPC: E01D19/10
Filed: 1992-04-16
Abstract: An apparatus for carrying out inspection and renovation works or the like on undersides of bridges is characterised by at least one cableway system arranged in the region of the bridge underside and at least one movable working platform (1) connected to the cableway system. The cableway system has at least two support cables (6, 7, 8) which are anchored on the bridge abutments (3, 4) and supported by cable shoes (11) which are fastened to the supporting framework (2) of the bridge. The working platform (1) can be moved on the support cables (6, 7, 8) via cable rollers (17). <IMAGE>
Patent CS-157191-A3 (CS)
Title: Pyrrido/3,4-b/pyrrolo/1,2-e//1,4,5/oxadiazepines
Inventor: EFFLAND RICHARD C
IPC: C07D498/14
Filed: 1991-05-24
Abstract: There are disclosed various compounds of the formula below, <CHEM>  where   X   is hydrogen, halogen or loweralkyl; Y   is hydrogen, halogen, loweralkyl, loweralkoxy or trifluoromethyl;   R1   is hydrogen, loweralkyl, aryl, arylloweralkyl, diloweralkylaminoloweralkyl or <CHEM>  R3 being hydrogen, loweralkyl or arylloweralkyl; and R2   is hydrogen, loweralkyl or arylloweralkyl; which compounds are useful as analgesic agents, and a process for their preparation.
Patent CZ-220788-A3 (CZ)
Inventor: HUDCOVSKY JAN
IPC: F15B15/12
Filed: 1988-04-01
Abstract: Hydromotor s kývavým pohybom pozostáva z telesa (1),
ktoré je uzatvorené z oboch stráň vekami (2,3) a v ktorom j e
otočné uložené pohyblivé hradidlo (4). V hornej časti pohyblivého
hradid la (4) je vytvořená priebežná drážka (7), v
kto rej je posuvné uložená vložka (5) štvorhranného prierezu.
Vložka (5) je na hornej straně opatre ná těsněním (6)
opierajúcim sa o vnútorný prie mer telesa hydromotora a na
spodnej straně tes nením opierajúcim sa o dno priebežnej
drážky (7). V alternatívnom převedení je vložka opatre ná
těsněním tiež na bočných stranách, pričom tieto tesnenia sa
opierajú o veká uzatvárajúce teleso hydromotora. Opotrebenie
časti tesnenia, ktorá je v styku s telesom hydromotora je
kom penzované posuvom vložky v priebežnej drážke hradidla
smerom k utesftovacej ploché.
Patent CZ-247789-A3 (CZ)
Title: Device for non-destructive multiparametric determination of metallic material structure mechanical state
Inventor: KELLER LIBOR ING CSC
IPC: G01R33/02
Filed: 1989-04-20
Abstract: In a materials testing method employing measurements of the magnetic flux induced in a sample of the material under test by an applied field, an operating period is divided into n (i.e. 2 or more) intervals. During these intervals, determinations of the intensity of the applied field are carried out to give n values that are formed into an n-dimensional vector representing field intensity. A corresponding set of n values of the flux induced in the material is obtained and formed into a further n-dimensional vector representing induced flux. Analysis of the vectors yields information on structural and mechanical properties of the material. A computer 8 controls units 1, 3, 6, 7 via data-buses 9, 10 in equipment suitable for carrying out the method. <IMAGE>
Patent CZ-299192-A3 (CZ)
Title: Method of packing cover of coke-oven battery filling hole, and apparatus for making the same
Inventor: PASIK MILAN
IPC: C10B25/20
Filed: 1992-09-30
Abstract: A method for sealing a closure of the feeding hole of the coke oven battery is based in this principle, that the sealing surface of the frame closed to the feeding hole is blown by pressed air and after having reversed of the closure, the sealing is completed with the use of sealing compound. The device is created based on the blowing ring (5) equipped with the jets (6), fixed on the cover scanner closed to the coke chamber and connected to the compressor unit (1) via the electromagnetic valve (5) and the pressure chamber (2).
Patent CZ-343391-A3 (CZ)
Inventor: CHVOJ MIROSLAV ING CSC
IPC: G01N27/02
Filed: 1991-11-13
Abstract: Zařízení je vytvořeno spojením amplitudově stabilního generátoru
(1) s měřicísondou (2) zapojenou v sérii s měřicím
odporem (3). Napětí z měřicího odporu (3) je usměrněno
usměrňovačem (4) a přivedeno na digitální voltmetr (5), na
jehož displeji lze odečíst hodnotu měrné elektrické vodivosti
měřeného medu.
Patent CZ-350992-A3 (CZ)
Title: Copolymers and their use as sliding and separating agents when treating thermoplastic materials
Inventor: HEINRICHS FRANZ-LEO
IPC: C08F220/10
Filed: 1992-11-27
Abstract: Copolymers prepared by free-radical polymerisation of a C12-C60- alpha -olefin with a carboxylic acid of the formula CH2 = CR<1>-COOH, a carboxylate of the formula CH2 = CR<1>-COOR<2> and optionally a styrene compound, prove to be highly effective lubricants and release agents in polymers, in particular in polyvinyl chloride, which hardly affect the transparency of the polymers.
Patent CZ-404091-A3 (CZ)
Title: Indole derivatives, process of their preparation and pharmaceutical preparations in which said derivatives are comprised
Inventor: DOWLE MICHAEL DENNIS
IPC: C07D209/24
Filed: 1991-12-23
Abstract: Indole derivatives of the general formula (I) are disclosed: <IMAGE>  (I)  where R1 is H or an alkyl or alkenyl group, R2 is H, or an alkyl, alkenyl, aryl, aralkyl or cycloalkyl group; R3 is H or an alkyl group; R4 and R5 are independently H or an alkyl or propenyl group or together form an aralkylidene group; and Alk is an optionally substituted alkylene chain; and their physiologically acceptable salts and solutes. These compounds are potentially useful for the treatment of migraine and may be formulated as pharmaceutical compositions in conventional manner. Various methods for the production of the compounds are disclosed including a Fischer-indole cyclization process.