baber/WOPTO huggingface dataset:
Patent RU-2639535-C2 (RU)
Title: Способ скрининга противоопухолевых препаратов - ингибиторов parp1 на основе биохимических методов анализа
Inventor: STUDITSKIJ VASILIJ MIKHAJLOVICH
IPC: C12Q1/68
Filed: 2015-12-07
Granted: 2017-12-21
Abstract: Изобретение относится к биохимии, в частности к способу скрининга противоопухолевых препаратов - ингибиторов PARP1. Для осуществления указанного способа проводят сборку нуклеосом из очищенных гистонов на ДНК-матрицах, затем лигирование с РНК-полимеразой и внесение в полученный комплекс молекулярной мишени - белка PARP1, с последующим внесением буфера транскрипции, а также тестируемых химических соединений. При этом указанный буфер транскрипции содержит дезоксинуклеотидтрифосфаты (дНТФ) и меченый α-32Ф-ГТФ. Далее проводят транскрипцию и оценку продуктов транскрипции путем их разделения с помощью электрофореза. Вывод о наличии у тестируемого соединения PARP1-ингибирующей активности делают при наличии на электрофореграмме полос в точках +15, +45 и в области run-off, показывающих паузирование транскрипции, как показано на фиг. 1, причем указанную оценку активности проводят с референсным значением PARP1 с НАД. Настоящее изобретение позволяет повысить специфичность и селективность системы отбора молекул на основе нуклеосом. 18 з.п. ф-лы, 2 ил., 7 пр.
Patent RU-2647756-C2 (RU)
Title: Компонент часового механизма
Inventor: ShARBON Kristian
IPC: G04B43/00
Filed: 2014-05-09
Granted: 2018-03-19
Abstract: Изобретение относится к микромеханическому компоненту часового механизма (1), включающего в себя металлическое изделие, сформированное из однокомпонентного материала. В соответствии с указанным изобретением указанный однокомпонентный материал представляет собой тип высокоинтерстициальной аустенитной стали, содержащей по меньшей мере один неметалл в качестве межузельного атома в количестве, находящемся в пределах от 0,15% до 1,2% от полной массы указанного материала. 4 н. и 15 з.п. ф-лы, 5 ил., 1 табл.
Patent RU-2648600-C2 (RU)
Title: Установка для автоматизированного изготовления сварного конуса на трубе
Inventor: Arnautov Vitalij Aleksandrovich
IPC: B23K37/00
Filed: 2016-04-29
Granted: 2018-03-26
Abstract: Изобретение относится к области термической обработки и может быть использовано для изготовления сварного конуса на трубе, например, при производстве винтовых свай. Установка включает станину, на которой  установлен с возможностью вращения посредством привода шпиндель, выполненный с возможностью размещения и фиксации внутри него трубной заготовки, механизм загиба секторов, установленный на шпинделе, режущий инструмент для раскроя секторов на конце трубной заготовки, сварочный инструмент для сварки секторов между собой с образованием конуса и механизм перемещений упомянутых инструментов. Использование изобретения позволяет упростить процесс изготовления конуса на трубе. 2 ил.
Patent RU-2767051-C2 (RU)
Title: High-penetration prodrug compositions based on peptides and peptide-related compounds
Inventor: YUJ CHunsi
IPC: C07K7/08
Filed: 2010-05-10
Granted: 2022-03-16
Abstract: FIELD: pharmaceutics.SUBSTANCE: invention relates to the use of compositions with a high degree of penetration based on a peptide or a peptide-related compound containing a functional unit, a linker and a transport unit, for preventing and/or treating a condition or disease amenable to treatment with parent peptides or related peptides. Functional unit is covalently linked to the transport unit by means of a linker and contains a fragment of a peptide or a peptide-related compound. Transport unit contains an amine group capable of protonation. Linker contains a chemical bond capable of splitting after penetration of the composition through the biological barrier.EFFECT: prodrug compositions with high degree of penetration based on peptides and peptide-related compounds are proposed.26 cl, 2 dwg, 16 tbl, 6 ex
Patent RU-2674921-C2 (RU)
Title: Жидкокристаллический дисплей в сборе и электронное устройство
Inventor: LI GUOSHENG
IPC: G02F1/133
Filed: 2016-05-19
Granted: 2018-12-13
Abstract: Изобретение относится к области устройств отображения, а именно к жидкокристаллическим дисплеям в сборе. Устройство содержит сенсорный экран, верхнюю и нижнюю подложки, слой жидких кристаллов, верхний и нижний поляризатор. По меньшей мере один датчик идентификации отпечатков пальцев расположен между верхним поляризатором и нижним поляризатором, причем каждый из датчиков идентификации отпечатков пальцев электрически соединен с управляющей интегральной схемой. По меньшей мере один датчик освещенности расположен или между верхним поляризатором и нижним поляризатором, или на сенсорном экране. Каждый из датчиков освещенности электрически соединен с управляющей интегральной схемой, при этом устройство выполнено с возможностью выбора некоторых из датчиков идентификации отпечатков пальцев с помощью по меньшей мере одного датчика освещенности для выполнения идентификации отпечатков пальцев. Изобретение позволяет уменьшить расходование энергии. 2 н. и 10 з.п. ф-лы, 8 ил.
Patent RU-2700599-C2 (RU)
Title: Method and device for assembling tires for vehicle wheels
Inventor: CREPALDI ANDREA
IPC: B29D30/28
Filed: 2015-11-26
Granted: 2019-09-18
Abstract: FIELD: transportation. 
     SUBSTANCE: invention relates to method and device for assembling tyres of vehicle wheels. Reinforcing circular structural element (7a) of tire (2), which is in process of manufacture, is formed by means of the following operations. Forming drum (19) is placed, which carries surface ("S1") from outside for application in preset position. Application element (46) is arranged to apply force towards surface ("S1") for application in preset position. Continuous elongated element (34) is directed in longitudinal direction to place ("P") of application between surface ("S1") for application and working surface (48) formed by element (46) for application. Continuous elongated member (34) is wound in circumferential direction around surface ("S1") for application to form coils ("C") which are adjacent to each other in axial direction. During winding working surface (48) of element (46) for application functions close to at least one of turns ("C"), previously formed by continuous elongated element (34), when adjoining to it. 
     EFFECT: technical result of the invention is higher quality of products. 
     47 cl, 12 dwg
Patent RU-2686781-C2 (RU)
Inventor: KUCHMIN IGOR BORISOVICH
IPC: G05D16/06
Filed: 2017-08-29
Granted: 2019-04-30
Abstract: FIELD: oil, gas and coke-chemical industries. 
     SUBSTANCE: gas pressure regulator includes actuator, stabilizer, pilot and monitor connected to each other in technological order by means of pulse gas lines. Regulator additionally includes an accelerator providing for operation of the monitor at failure of the regulator, and a silencer installed in the reduction zone between the valve and the movable seat of the regulator. Accelerator is a housing with a cover, between which a movable system is fixed, which ensures transfer of spring force to a valve installed in the accelerator housing. In the accelerator housing there is an internal channel through which the control pressure created by the pilot is released from the chamber of the actuator into the chamber of the accelerator with pulse pressure. Noise silencer is made in the form of at least one foam metal ring with porosity of not more than 10 ppi. 
     EFFECT: higher reliability and accuracy of valve reduction. 
     1 cl, 3 dwg
Patent RU-2760638-C2 (RU)
Title: Balanced spring fastened with elastic washer
Inventor: ERNANDES Ivan
IPC: G04B17/00
Filed: 2017-10-04
Granted: 2021-11-29
Abstract: FIELD: fastening means. 
     SUBSTANCE: present invention relates to a bushing designed for fixing a balanced spring on the axis by elastic clamping with a washer. The bushing elastically fixed on the axis is proposed, the geometry of which provides less internal stresses, in particular, at points of contact and at vertices of a polygon. 
     EFFECT: reduction in contact stresses bending stresses in a tape. 
     9 cl, 5 dwg
Patent RU-2717419-C2 (RU)
Title: Binder system for reducing interaction of metal with mold
Inventor: VAN SYANPIN
IPC: B22C1/22
Filed: 2016-05-16
Granted: 2020-03-23
Abstract: FIELD: production of casting moulds. 
     SUBSTANCE: binder system for refractory materials used in sand casting processes, in particular two-component binder systems based on polyurethane, used in the method of making rods in cold boxes or a method using cold curing, characterized by a lower degree of interaction of metal with the mould. Method production of moulds and rods for metal casting involves the following stages: providing system of organic binder and refractory moulding material, wherein the organic binder system is presented in the form of three components which are not combined until use, wherein the third component contains at least alkyl orthoformate; mixing at least first two components of organic binder system with refractory moulding material to obtain mouldable mixture for foundry production; moulding a mouldable mixture for moulding into a mould or a rod and curing of the moulded mould or rod. 
     EFFECT: binder system is disclosed to reduce interaction of metal with mould. 
     9 cl, 2 tbl
Patent RU-2725616-C2 (RU)
Inventor: DING XIAO
IPC: A61K31/506
Filed: 2016-07-22
Granted: 2020-07-03
Abstract: Изобретение относится к новым соединениям формулы (I) или его фармацевтически приемлемым солямгде X выбран из CH или N; Y CR, и Rпредставляет собой метил; Rвыбран из группы, состоящей из 5- или 6-членного гетероциклила, необязательно замещенного одним, двумя или тремя заместителями, независимо выбранными из группы, состоящей из Cалкила, необязательно дополнительно замещенного одним Cалкоксилом, Cалкоксила, галогена, гидроксила, -SOCH, -COCH, оксогруппы, и оксетанила, -O-4-6-членного гетероциклила, необязательно замещенного одним или двумя заместителями Cалкил, которые могут быть одинаковыми или различными, и Салкоксила; и Rпредставляет собойгде Zи Zнезависимо представляют собой N или CR, и где Rпредставляет собой H или Cалкоксил, но Zи Zне могут оба быть CR, Rвыбран из группы, состоящей из CN, Cалкила, Cалкоксила, -O-Cгалогеналкила, и Cциклоалкила; и Rвыбран из группы, состоящей из 2-окса-6-азаспиро[3.4]октанила, Cциклоалкила, необязательно замещенного одним гидроксилом, -CONHCH, -NHCOCH, 4-6-членного гетероциклила, необязательно замещенного одним или двумя заместителями, независимо выбранными из группы, состоящей из гидроксила, CN, -CONHCH,оксетанила, Cалкила, необязательно замещенного одним гидроксилом, и Cалкоксила, необязательно замещенного одним гидроксилом, которые ингибируют активность киназы LRRK2, способам их получения, к композициям, содержащим их, и к их использованию при лечении или профилактике заболеваний, характеризующихся активностью киназы LRRK2, например болезни Паркинсона, болезни Альцгеймера и бокового амиотрофического склероза (ALS). 4 н. и 11 з.п. ф-лы, 273 пр.
Patent RU-2744570-C2 (RU)
Inventor: SANZ MENENDEZ NURIA
IPC: A61P27/02
Filed: 2016-09-05
Granted: 2021-03-11
Abstract: FIELD: pharmaceuticals.SUBSTANCE: group of inventions relates to the field of pharmaceuticals, namely to an aqueous ophthalmic pharmaceutical composition and its use for the local treatment of eye pain. The composition contains tramadol or its pharmacologically acceptable salt as the sole active ingredient at a concentration of 0.04% wt. / vol. to 0.07% wt. /vol., expressed as an equivalent concentration of tramadol hydrochloride, an isotonant, a pH-regulating substance, and water as the carrier medium.EFFECT: group of inventions provides a composition with very high efficacy for the local treatment of eye pain with tramadol content in the range of low concentrations of 0.04–0.07% wt. /vol. and in the absence of other active ingredients.13 cl, 2 tbl, 2 ex
Patent RU-2711273-C2 (RU)
Inventor: SLOOFF ARJEN HAMILCAR
IPC: B65D85/10
Filed: 2016-11-11
Granted: 2020-01-16
Abstract: Изобретение относится к контейнеру для товаров народного потребления, таких как сигареты, с закрывающейся внутренней упаковкой. Тара содержит внутреннюю упаковку, расположенную внутри корпуса. Внутренняя упаковка содержит первую область, проходящую вдоль продольной оси внутренней упаковки и содержащую первый и второй слои материала, который образует внутреннюю упаковку, и вторую область, смежную с первой областью, которая также проходит вдоль продольной оси. Вторая область содержит только первый слой и не содержит второго слоя. Первая область также содержит первую линию ослабления, расположенную в первом слое, которая определяет клапан, и вторую линию ослабления, расположенную во втором слое, которая определяет отверстие доступа, расположенное в первой области. Отверстие доступа покрыто клапаном, когда клапан находится в закрытом положении, и по меньшей мере частично открыто, когда клапан находится в открытом положении. 3 н. и 17 з.п. ф-лы, 8 ил.
Patent RU-2737825-C2 (RU)
Title: Ламинированное стекло
Inventor: MIYASAKA SEIICHI
IPC: H05B3/20
Filed: 2017-06-22
Granted: 2020-12-03
Abstract: Изобретение относится к ламинированному стеклу. Ламинированное стекло, содержащее: пару стеклянных пластин, расположенных напротив друг друга; пару промежуточных связывающих слоев, расположенных между парой стеклянных пластин, каждый из этих промежуточных связывающих слоев контактирует с соответствующей стеклянной пластиной; и основную пленку, расположенную между этой парой промежуточных связывающих слоев, которая снабжена проводкой по меньшей мере в части ее площади. Толщина одного из промежуточных связывающих слоев является более тонкой, чем толщина другого из промежуточных связывающих слоев. Толщина более тонкого промежуточного связывающего слоя из пары промежуточных связывающих слоев составляет 0,20 мм или меньше. Отношение толщин пары промежуточных связывающих слоев составляет 1:7 или больше. Технический результат - уменьшение оптического искажения, когда ток подается в ламинированное стекло, содержащее внутри основную пленку, в которой сформирована проводящая проводка. 7 з.п. ф-лы, 1 табл., 2 ил.
Patent RU-2746896-C2 (RU)
Inventor: TELLEFSEN MORTEN
IPC: C01B17/92
Filed: 2017-07-04
Granted: 2021-04-21
Abstract: FIELD: chemistry. 
     SUBSTANCE: invention can be used in synthesis of sulfuric acid. For synthesis of sulfur trioxide a supply stream, comprising sulfur-containing compounds and dissolved metals and alkali metals is combusted in the presence of an oxygen-enriched stream and auxiliary fuel if needed. Wherein the sulfur-containing compounds in the supply stream are converted into SO 2  and the dissolved metals and alkali metals are converted into partially solidified dust. The hot process gas from the combustion furnace is mixed with a colder gas stream in a mixing block so that the temperature of the combined stream is lower than the solidification temperature of the particles. The combined gas stream is cooled in one or two heat exchangers. The solidified dust particles are removed from the combined gas stream in a dust removal device. Hot dilution air is added to the process gas if needed to provide sufficient oxygen to oxidize SO 2  to SO 3  in an SO 2  converter. The process gas is supplied to the SO 2  converter, said converter comprising an array of catalyst layers with heat exchangers installed between the catalyst layers, converting SO 2  in the process gas to SO 3 . A system for synthesis of sulfur trioxide is proposed. 
     EFFECT: invention allows reducing deposit formation in equipment during synthesis of sulfur trioxide. 
     14 cl, 6 dwg, 1 tbl, 1 ex
Patent RU-2769098-C2 (RU)
Inventor: LI GEN
IPC: H04W72/04
Filed: 2019-04-05
Granted: 2022-03-28
Abstract: FIELD: communication. 
     SUBSTANCE: integral system information and configuration of demand channel resources are broadcasted, while integral system information is necessary to access a cell of the mentioned device, a request for at least part of optional system information other than integral system information is tracked via the demand channel, and part of optional system information is broadcasted in response to the request reception. 
     EFFECT: providing the possibility of broadcasting system information on demand to increase energy efficiency. 
     48 cl, 13 dwg, 1 tbl
Patent RU-2746816-C2 (RU)
Title: Humanized mice (htnfki/htnfr2ki) on c57bi /6 genetic basis with additional capability of htnfr2 conditional removal for biomedical research
Inventor: Nedospasov Sergej Arturovich
IPC: C12N15/00
Filed: 2019-05-16
Granted: 2021-04-21
Abstract: FIELD: biochemistry. 
     SUBSTANCE: invention relates to the field of biochemistry, in particular to the study of the mouse genome, which contains in the mouse locus TNFR2 gene containing human exons 2 to 6, encoding the extracellular part of human TNFR2 binding to human TNF, with the possibility of conditionally blocking the activity of the TNFR2 gene in cells expressing cre-recombinase. A method for studying the activity of therapeutic agents that bind to human TNF, including introduction of such agents to the above-mentioned mouse, is also disclosed.  The invention also relates to a method for studying the activity of therapeutic agents of agonists and antagonists binding to human TNFR2, including introduction of such agents to the above mouse.  
     EFFECT: invention is effective in the study of the properties of drugs used in  treatment of autoimmune diseases.  
     4 cl, 2 tbl, 4 ex, 3 dwg
Patent RU-2762147-C2 (RU)
Title: System and method for processing matrix of sample processing modules
Inventor: CHANG RONALD
IPC: G01N35/00
Filed: 2017-11-17
Granted: 2021-12-16
Abstract: FIELD: diagnostics. 
     SUBSTANCE: invention relates to systems and methods for high-performance processing of large volumes of biological samples and, in particular, to systems for conducting diagnostic analyses. A high-performance processing system for processing a set of biological samples, each of which is located in a corresponding cartridge for diagnostic analysis of a set of cartridges for diagnostic analysis, contains: a set of diagnostic analysis modules, a matrix support unit made with the possibility of supporting the set of diagnostic analysis modules in the matrix, an engine and a drive mechanism functionally connected to the matrix support unit and made with the possibility of gradual rotation of the matrix support unit, a loader made with the possibility of loading the set of cartridges for diagnostic analysis into the set of diagnostic analysis modules, while supported in the matrix support unit, while the loader can move between rows of the matrix support unit and is made with the possibility of loading and/or unloading the corresponding cartridge from any of the set of diagnostic analysis modules, so the diagnostic analysis cartridge is loaded into any of diagnostic analysis modules within the matrix by moving the matrix support unit relatively to the loader together with the loader, and a controller made with the possibility of coordinating the rotation of the matrix support unit in combination with the loader movement based on communication with the set of modules to facilitate high-performance analysis processing.  
     EFFECT: possibility of efficient processing of a large volume of samples with the possibility of using existing testing tools. 
     70 cl, 35 dwg, 1 tbl
Patent RU-2731018-C2 (RU)
Title: Modified sensor module for head protection device
Inventor: EGELAND MARC A
IPC: H04W4/80
Filed: 2017-06-22
Granted: 2020-08-28
Abstract: FIELD: physics. 
     SUBSTANCE: present invention includes a modified sensor module for use with a head protection device comprising a helmet and a visor. Sensor module comprises a housing for sensors and a fastening mechanism. Housing for sensors comprises a head detection sensor to determine when the head protection device is worn. Housing for sensors also comprises position sensor to determine position of visor relative to helmet. Modified sensor module further comprises a fastening mechanism attached to the housing. Fixing mechanism is joined with the first hinged component of the hinge unit in the head protection device for the detachable installation of the sensor module in the head protection device, wherein the hinge assembly allows the visor to move relative to the helmet. Present invention can enable users of head devices to effectively modernize their protective devices for the head to determine when the visor of the head protection device is open. It is possible to confirm that the user wears a protective device for the head, in some cases due to the use of the head detection sensor. 
     EFFECT: this information allows managers of safety programs to make sure that users of protective devices for the head comply with requirements for wearing protective devices for the head. 
     26 cl, 18 dwg
Patent RU-2769387-C2 (RU)
Title: Swing door drive
Inventor: SEDERKVIST SVEN-GUNNAR
IPC: E05F15/63
Filed: 2018-04-23
Granted: 2022-03-31
Abstract: FIELD: construction.SUBSTANCE: present invention relates to drive system (100) of swing fire door (100), comprising at least one swing door drive (1), wall (200), door frame (300) and at least one swing door leaf (400), wherein door frame (300) is installed in the wall opening, at least one swing door leaf (400) is pivotally connected to door frame (300), wall (200) comprises first wall section (201) on one side of door frame (300) and second wall section (202) on the other side of door frame (300), swing door drive (1) is installed on first section (201) walls, is connected to at least one leaf (400) of swing door and is adapted to move at least one leaf (400) of swing door between closed and open positions.EFFECT: disclosed is a swing door drive.18 cl, 7 dwg
Patent RU-2761375-C2 (RU)
Title: Method for transmitting control information and device
Inventor: DU BAI
IPC: H04L5/00
Filed: 2018-06-28
Granted: 2021-12-07
Abstract: FIELD: wireless communication.SUBSTANCE: first indication information is determined by a network device, while the first indication information is used for indicating, whether the information transmission impacts on the first frequency-time resource; the first indication information is transmitted by the network device via a physical downlink control channel; the first indication information is received by a terminal device, and it is determined, based on the first indication information, whether the information transmission impacts on the third frequency-time resource, where the third frequency-time resource is a frequency-time resource that is used for downlink information transmission between the terminal device and the network device.EFFECT: increase in the efficiency of data transmission.21 cl, 17 dwg, 6 tbl
Patent UA-46998-C2 (UA)
Title: Twofold drive of a belt conveyor                  twofold drive of a belt conveyor
Inventor: BRIUM VIKTOR ZYNOVIOVYCH BRIUM
IPC: B65G23/00
Filed: 2001-05-14
Abstract: A twofold drive of a belt conveyor has a frame and two universal drive modules, which are attached to each other by means of a vertical junction and are placed symmetrically in a plan view with respect to the junction plane. Each of those modules has a reducer, comprising of a quick and a slow part, a two-support drive drum with a cylindrical toothed wheel, hydro-muff and a motor. The body of the quick part of the reducer is fixed on the body of the slow part of the reducer, its input shaft is connected to the motor by means of the hydro-muff. The pinion of the intermediate shaft goes to the cavity of the slow part of the reducer. Bearing unit of one support is placed in the side wall of theforce structure of the drive module, and the bearing unit of the other support is installed in the body of the slow part of the reducer. Cylindrical toothed wheels of the both drive drums are placed in the cavities of respective bodies of the slow parts of the reducers, and are coupled with the bearings of intermediate shafts. In the vertical junction between the uniform drive modules a vertical intermediate insertion is mounted, arranged as a force structure, with the end contact surfaces being in the shape and dimensions identical to the surfaces of joining the uniform drive modules.