baber/WOPTO huggingface dataset:
Patent SG-11201805050W-A (SG)
Title: Intermediate fluid type vaporizer
Inventor: SHINJI EGASHIRA
IPC: F28D9/00
Filed: 2016-12-22
Abstract: WAn intermediate fluid type vaporizer 10 is equipped with: an intermediate fluid evaporator El that evaporates at least a part of a liquid intermediate fluid M through heat exchange between seawater and the intermediate fluid M; and an LNG evaporator E2 that vaporizes LNG by condensing the intermediate fluid evaporated by the intermediate fluid evaporator El and causes vaporized NG to flow out. The LNG evaporator E2 is configured by a stack-type heat exchanger having a stacked body which is formed with a first flow channel that is a channel for the flow of the intermediate fluid M and a second flow channel that is a channel for the flow of the LNG. The stack-type heat exchanger is installed in a posture where the first flow channels extend in an up-and-down direction or in a direction tilted relative to the up-and-down direction so that the intermediate fluid M flows down in the first flow channels due to gravity. 20
Patent SG-11201807141W-A (SG)
Title: Bearing monitoring device of railcar
Inventor: NISHIMURA TAKEHIRO
IPC: G01M99/00
Filed: 2017-01-17
Abstract: Provided is a bearing monitoring device of a railcar, the railcar being constituted by coupling a plurality of cars including carbodies and bogies, the bearing monitoring device including: bearing temperature sensors provided at the respective bogies and configured to directly or indirectly detect temperatures of bearings of the bogies; at least one state sensor provided at at least one of the carbodies of the plurality of cars and configured to be used for calculating loads or rotating speeds of the bearings; and a storage unit provided at at least one of the carbodies of the plurality of cars and configured to store data pieces of signals detected by the bearing temperature sensors and the state sensor.
Patent SG-11201811655S-A (SG)
Title: Trpa1 antagonists for treatment of dry eye, ocular pain and inflammation
Inventor: HERZ JEFFREY M
IPC: C07D251/02
Filed: 2017-07-06
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111111111111111111111111111111111111111111111111111111111110111111 Organization 0 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/009717 Al 11 January 2018 (11.01.2018) W I PO I PCT (51) International Patent Classification: C07D 251/02 (2006.01) C07D 401/04 (2006.01) (21) International Application Number: PCT/US2017/040976 (22) International Filing Date: 06 July 2017 (06.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/359,122 06 July 2016 (06.07.2016) US (71) Applicant: ALGOMEDIX, INC. [US/US]; 16212 Both- ell-Everett Highway, Suite F280, Mill Creek, Washington 98012 (US). (72) Inventors: HERZ, Jeffrey M.; 16212 Bothell-Everett Highway, Suite F280, Mill Creek, Washington 98012 (US). _ KESICKI, Edward A.; 16212 Bothell-Everett Highway, Suite F280, Mill Creek, Washington 98012 (US). ZUTA, Charles P.; 16212 Bothell-Everett Highway, Suite F280, — Mill Creek, Washington 98012 (US). = Designated States (unless otherwise indicated, for every (81) kind of national protection available): AE, AG, AL, AM, _ AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, — CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, = = —= MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = = Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = (84) = = = EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, = — MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). = Published: — — with international search report (Art. 21(3)) Il IN 11 Ir ---- (54) Title: TRPA1 ANTAGONISTS FOR TREATMENT OF DRY EYE, OCULAR PAIN AND INFLAMMATION 01 © (57) : Stable, clear, ophthalmic formulations and methods of use for an opthalmologically therapeutic effective amount of 0 ----. a TRPA1 antagonist, the formulation comprising buffer system, a viscosity enhancing agent, optionally a preservative, with an opthal- GC mologically acceptable osmolarity and pH, all in an aqueous vehicle. These formulations are effective for treating ocular diseases or 1-1 © conditions caused by, or associated with, or accompanied by ocular pain and inflammatory processes, including, among others, dry eye N disease, uveitis, or any trauma caused by eye surgery or eye injury. C
Patent SG-11201901064P-A (SG)
Title: Hot-pressing press tool, method of operating it, and corresponding installation and method of manufacture
Inventor: GABEN FABIEN
IPC: H01M4/04
Filed: 2017-08-22
Abstract: This hot-pressing press tool, intended to be mounted on a press, comprises: - a first tool part () equipped with first means (29; 60) of attachment to a first press platen (12), - a second tool part (3) equipped with second means (13, 14; 60) of attachment to a second press platen (10), these two tool parts being mobile relative to one another between a distant position and a close-together position, in which they delimit a pressing chamber (300), - means (5) of heating the interior volume of the pressing chamber, - the first and second tool parts also being respectively equipped with a first and a second pressing member (28, 38), which members are able to apply a pressing force to opposite faces of an object that is to be pressed, received in the pressing chamber. According to the invention, the heating means are means of heating by optical radiation (5) and the tool further comprises concentration means (26, 28, 46) able to concentrate the energy of the radiation towards the said object. In that way, the optical radiation is directed at the entirety of the object that is to be pressed but, by contrast, no substantial proportion of this radiation passes outside the lateral edges of this object. A preferred, although not exclusive, use of this tool is the creation of solid-state lithium-ion batteries. Fig. 12
Patent SG-11201906215V-A (SG)
Title: X-ray markers for scaffolds
Inventor: BAYER ULLRICH
IPC: A61F2/04
Filed: 2018-01-08
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 July 2018 (19.07.2018) WIPO I PCT omit VIII °nolo mmono iflo oimIE (10) International Publication Number WO 2018/130489 Al (51) International Patent Classification: A61F 2/82 (2013.01) A61F 2/04 (2013.01) (21) International Application Number: PCT/EP2018/050345 (22) International Filing Date: 08 January 2018 (08.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17150973.0 11 January 2017 (11.01.2017) EP (71) Applicant: BIOTRONIK AG [CH/CH]; Ackerstrasse 6, 8180 Billach (CH). (72) Inventors: BAYER, Ullrich; Am Brink 11, 18209 Bad Doberan (DE). RISCH, Fabian; Vorstadt 13, 8200 Schaffhausen (CH). RIEDMULLER, Johannes; Dahlmannstrasse 98, 90491 Niirnberg (DE). QUINT, Bo- do; Hauptstrasse 38, 79802 Dettighofen (DE). (74) Agent: RANDOLL, Soren; BIOTRONIK SE & Co. KG, Woermannkehre 1, 12359 Berlin (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: X-RAY MARKERS FOR SCAFFOLDS 22 200 FIG. 8 1-1 (57) : The invention relates to a method for producing x-ray markers (1), during which method a predetermined breaking point (21) is severed in order to detach x-ray markers (1) from part (22) of a material layer (2). The invention also relates to an x-ray marker, C a medical implant, and a semifinished product. [Continued on next page] WO 2018/130489 Al MIDEDIMOMOIDEIREIE3011100VIVEHMOVOIMIE Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.17(i)) as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3))
Patent SG-11201906670P-A (SG)
Title: Early detection of glial cell activation in neurodegenerative or neuroinflammatory diseases
Inventor: ZAUDERER MAURICE
IPC: A61K39/00
Filed: 2018-02-20
Abstract: Continuetreatment with VX for 11 nths . 3 month — safety follow-up Database anilyAil for Cohort AA (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 30 August 2018 (30.08.2018) WIP0 I PCT °Ens °nolo HE KIEm ioo Homo iflo oimIE (10) International Publication Number WO 2018/156509 Al (51) International Patent Classification: A61K 45/00 (2006.01) A61K 39/00 (2006.01) C07K 16/28 (2006.01) (21) International Application Number: PCT/US2018/018794 (22) International Filing Date: 20 February 2018 (20.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/461,945 22 February 2017 (22.02.2017) US (71) Applicant: VACCINEX, INC. [US/US]; 1895 Mt. Hope Avenue, Rochester, NY 14620 (US). (72) Inventor: ZAUDERER, Maurice; 44 Woodland Road, Pittsford, New York 14534 (US). (74) Agent: HAANES, Elizabeth J. et al.; FisherBroyles LLP, 945 East Paces Road NE, Suite 2000, Atlanta, GA 30328 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (54) Title: EARLY DETECTION OF GLIAL CELL ACTIVATION IN NEURODEGENERATWE OR NEUROINFLAMMATORY = DISEASES FIGURE 1 Screen Subjects 41-36 6 mon blinded treatment, Vms or placebo rEnrollN into Signal Cohort I subjects ssover to open a be I VX15 Dat base: oek a rid ': aha7ysis of 6 d' el (57) : The disclosure provides a method for determining the efficacy of treatment with a SEMA4D antagonist, e.g., a SEMA4D antagonist antibody in the treatment of a neuroinflammatory or neurodegenerative disease, disorder, or injury, where the method pro- t vides differential measurement of glucose uptake in the brain, e.g., by FDG-PET imaging.
Patent SG-11201907260P-A (SG)
Title: Physiologically active substance carrier
Inventor: WON CHEOLHEE
IPC: C01B33/12
Filed: 2018-02-06
Abstract: 22 【】 The present invention provides a bioactive substance carrier, which includes: a bioactive substance; and porous silica particles supporting the bioactive substance and having a plurality of pores with a diameter of 5 nm to 100 5 nm, wherein the porous silica particles have particular physical properties, can deliver all various drugs by a supported amount in a sustained manner, and can be parenterally administered. 10 Fig.8
Patent YU-49474-B (YU)
Inventor: LEWIS ARTHUR
IPC: C07H1/00
Filed: 1995-02-17
Abstract: Postupak za dobijanje 2--D-ribofuranoziltiazol-4-karboksiamida formule I koji se odvija u pet faza, naznačen time, što se u fazi (a) reagovanjem 1-O-acetil-2,3,5-tri-O-benzoil- -D-ribofuranoze formule II, rastvorene u metilen-hloridu i rastvor ohlađen na 0 do 2В°C, sa trimetilsilil-cijanidom, u prisustvu kalaj(IV)-hlorida kao katalizatora, pri čemu se reakcija odvija na -5 do 0 В°C u toku 90 minuta, dobija 2,3-anhidro-3,4,6-tri-O-benzoil--D-alononitril (cijano šećer) formule III, posle čega se dobijeni cijano šećer, u fazi (b), u smeši sa metanolom i natrijum-metoksidom, na temperaturi od 35 do 45 В°C, uz mešanje u atmosferi azota u toku tri sata prevodi u metil-2,5-anhidro-D-alonimidat formule IV; a dobijeni alonimidat, u sledećoj fazi (c), u etanolu u prisustvu trietilamina ohlađen na 0В°C sa gasovitim vodonik-sulfidom na temperaturi -5 do 2 В°C, uz mešanje, daje 2,5-anhidro-D-alontioamid formule V, posel čega se reakcija odvija još jedan sat na sobnoj temperaturi, do potupnog izdvajanja proizvoda tioamida, koji se u fazi (d) kondenzuje sa etil-α-brom-piruvatom, u toku 10-14 časova, na sobnoj temperaturi u tetrahidrofuranu, pri čemu dolazi do stvaranja etil-2--D-ribofuranozil-tiazol-4-karboksilata formule VI, koji se dodaje, u poseldnjoj fazi (e), u rastvor metanola zasićenog amonijakom, i ohlađenim na -20В°C, da bi se posle stajanja na 4 do 8 В°C, u toku dva dana dobio proizvod 2--D-ribofuranoziltiazol-4-karboksamid formuel I. Prijava sadrži još 4 zavisna patentna zahteva.
Patent AT-402848-B (AT)
Title: Fluid heater
IPC: F24D18/00
Filed: 1994-03-10
Granted: 1997-09-25
Abstract: What is proposed is a thermocouple battery for a fuel-heated heat source, whether it be an air heater, flow heater, closed-circuit heater or water storage heater or a boiler, in which the hot soldered joints 37 are assigned to a structural part highly heated by the burner 2 of the heat source and the cold soldered joints 38 are assigned to the heat transfer medium to be heated, for example a cold-water line, the combustion-air supply line or a return line 36, the thermocouple battery serving for feeding external consumers. As a result, on the one hand, electrical energy is generated, and, on the other hand, the waste heat occurring during the generation of electrical energy is supplied, without loss, for the primary purpose of the heat-source arrangement, specifically the heating of a heat transfer medium. The heat exchanger 11 and the water inflow may each have, for example, a jacket 65; 68 composed of a two-component compound acting as a thermocouple, and the two-component elements of the two jackets may be connected to one another via insulating electrical leads 62, 63, at least one of the electrical leads 63 having a consumer connection 64. <IMAGE>
Patent DK-155883-B (DK)
Inventor: WESTWOOD ROBERT
IPC: C07D487/04
Filed: 1981-02-13
Abstract: Novel triazoloquinazolinones of the formula    <IMAGE>  (I)  wherein X is selected from the group consisting of hydrogen, halogen, -NO2, methyl, methoxy and -CF3, n is an integer from 2 to 5, R1 and R2 are individually selected from the group consisting of hydrogen and alkyl and hydroxyalkyl of 1 to 5 carbon atoms and taken together with the nitrogen atom to which they are attached form a saturated heterocycle optionally containing another heteroatom and optionally substituted with at least one member of the group consisting of hydroxy, alkyl and hydroxyalkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, acyl of an aliphatic carboxylic acid of 1 to 5 carbon atoms, alkoxycarbonyl of 2 to 6 carbon atoms and aryl optionally substituted with a halogen or -CF3 and their non-toxic, pharmaceutically acceptable acid addition salts having antihistaminic and bronchospasmolytic activity and their preparation.
Patent HU-188740-B (HU)
Inventor: SAMSOMDI KISS KAROLY
IPC: E02D27/34
Filed: 1983-03-11
Abstract: A találmány tárgya rengésálló alapozás főleg lakóépületek rezgések elleni védelmére, pl. földrengések káros hatásának kiküszöbölésére. Az alapozásnak a rezgések továbbadódását meggátló mozgáscsillapító résszel rendelkezik, a mozgáscsillapító rész pedig célszerűen rugalmas anyaggal, pl. gumiszalaggal tömítetten lezárt túlnyomásos teret tartalmaz. Jellegzetessége, hogy a túlnyomásos teret két vasbeton lemez által közrefogott, előnyösen az épület teljes alaprajzi kontúrja alatt elhelyezkedő túlnyomásos levegőtér alkotja. A vasbeton lemezek a túlnyomásos levegőtér felé néző felületük mentén szigeteléssel, célszerűen acéllemez szigeteléssel vannak ellátva. A két vasbeton lemez oldható kötésekkel, pl. csavarokkal van összekötve, a csavarok feje az alsó lemezben lévő fészekben, menetes vége, valamint a hozzátartozó csavaranya és alátét rugó a fölső lemezben lévő fészekben helyezkedik el. A fölső lemez oldalirányban a szélerők fölvételére alkalmas rugalmas anyaggal, célszerűen rugókkal van megtámasztva, az alsó lemez pedig rugalmas borítással, pl. filclemez és adott esetben azbesztlemez réteggel van ellátva.  2. ábra -1-
Patent YU-43162-B (YU)
Title: Interpolymer latex, process for preparation and use thereof, especially as binder at paper coating
Inventor: REEB R
IPC: C08F257/02
Filed: 1983-03-23
Abstract: Latex of an interpolymer composed of (1) a copolymer A of butadiene, styrene and at least one ethylenically unsaturated carboxylic acid, and (2) a polymer B of at least one halogenoalkyl or halogenoacetoxyalkyl ester of an ethylenically unsaturated monocarboxylic or dicarboxylic acid, polymer B being at least partially grafted onto the copolymer A. The latex is prepared by the emulsion polymerization of butadiene, styrene and at least one copolymerizable, ethylenically unsaturated carboxylic acid to form a copolymer latex, followed by the polymerization in the presence of the copolymer latex of a halogenoalkyl or halogenoacetoxyalkyl ester of an ethylenically unsaturated monocarboxylic or dicarboxylic acid. The latex may be used as a binder in aqueous compositions for coating paper.
Patent AT-399862-B (AT)
IPC: B01D17/02
Filed: 1993-10-05
Granted: 1995-08-25
Abstract: PCT No. PCT/AT94/00133 Sec. 371 Date Jun. 5, 1995 Sec. 102(e) Date Jun. 5, 1995 PCT Filed Sep. 16, 1994 PCT Pub. No. WO95/09684 PCT Pub. Date Apr. 13, 1995Proposed is a light-liquid offtake system designed for installation in a separator basin, the device having a separator tank with an inlet port for the liquid mixture to be separated, an overflow port for light liquid, an overflow port for water, a collector tank for the light liquid and a collector tank for the water. Both tanks contain a float. When the level in a tank exceeds a predetermined limit, the floats actuate closure devices fitted to close off the separator-tank inlet port and prevent water flowing back into the separator tank.
Patent AT-401150-B (AT)
Inventor: BRUGGERS J W ING
IPC: B26B19/10
Filed: 1993-10-21
Granted: 1996-06-25
Abstract: The invention relates to an apparatus (1) for cutting hair, having a first cutter (10) and a second cutter (12), which are retained pressed against one another resiliently in a press-on direction (15), and having a drive part (19) for driving the second cutter (12), and having an articulation device (20) between the drive part (19) and the second cutter (12). In the case of said apparatus, the articulation device (20) exhibits two webs (21, 22) which are inclined counter to the press-on direction (15) and are each connected to the drive part (19) and the second cutter (12) via in each case one articulation (23, 24, 25, 26), the two straight connection lines (27, 28) through the two articulations (23, 25 and 24, 26, respectively) of each web (21, 22) intersecting one another essentially in the region of the point (29) of action of the resultants of the friction forces between the two cutters (10, 12). <IMAGE>
Patent AT-413978-B (AT)
IPC: B65D47/32
Filed: 2003-01-20
Granted: 2006-07-15
Abstract: An air valve for the cap of a liquid container comprising an annular membrane. The cap has at least one air passage opening. A holding element having an encircling groove that is open toward the inside of the cap is fixed to the inside of the cap. This holding element has at least one air inlet opening connected to the air passage opening of the cap and which leads into the groove. A ring can be placed or is placed inside the groove. Also provided is a mouthpiece for drinking from a liquid container, which is made, in essence, of elastic material and placed on a cap provided with the inventive air valve.
Patent FI-64131-B (FI)
Inventor: JARCHO MICHAEL
IPC: A61K6/838
Filed: 1975-07-31
Granted: 1983-06-30
Abstract: 1522182 Calcium phosphate ceramics STERLING DRUG Inc 22 July 1975 [2 Aug 1974 7 July 1975] 30706/75 Heading C1A A polycrystalline, sintered ceramic for use as a bone or tooth substitute is made by reacting calcium ion with phosphate ions in aqueous medium at pH of 10-12 to produce a gelatinous calcium phosphate precipitate having a Ca:P molar ratio of 1À44-1À72, separating the precipitate from the solution and heating the precipitate to above 1000‹C but below the temperature at which appreciable decomposition of hydroxylapatite occurs and maintaining said temperature for a sufficient time to effect sintering and maximum densification. When the Ca:P molar ratio is in the range 1À62-1À72 a translucent, isotropic, polycrystalline hydroxylapatite having an average crystalite size of 0À2-3 microns, a density of 3À1-3À14 g/cm<SP>3</SP>, substantially no pores and having cleavage along smooth curved planes is obtained. When the Ca:P ratio is in the range 1À44-1À60, preferably 1À46-1À57 a dense isotropic two-phase ceramic is obtained comprising 14-98% hydroxylapatite and 2-86% whitlockite, said ceramic having substantially no pores and having cleavage along smooth curved planes. The reactants are preferably Ca(NO 3 ) 2  and (NH 4 ) 2 HPO 4 . 0À4-0À6% of an organic binder, e.g. collagen, may be added to the precipitate to prevent cracking during drying. Porous forms of the ceramic may be made by including 5-25% by weight of organic binders such as powdered cellulose, starch, cotton or collagen to the precipitate. Fluoride ions may be introduced into the ceramic, e.g. by standing in 0À5-5% aqueous NaF for 12 hours-5 days.
Patent FI-69850-B (FI)
Inventor: WIECHERT RUDOLF
IPC: C07J1/00
Filed: 1980-10-24
Granted: 1985-12-31
Abstract: 17 alpha -substituted steroids of the formula   <IMAGE>   wherein R1 is hydrogen, acyl, alkyl, alkenyl, alkyl or alkenyl interrupted by an oxygen atom, cyclopentyl, or tetrahydropyranyl, R2 is alkyl or alkenyl of 2-6 carbon atoms, X is oxygen or the grouping H(OR3) wherein R3 is hydrogen, acyl, alkyl, alkenyl, alkyl or alkenyl interrupted by an oxygen atom, cyclopentyl, or tetrahydropyranyl, upon topical application, display antiandrogenic properties and can be utilized for the treatment of acne, seborrhea, alopecia and hirsutism.