baber/WOPTO huggingface dataset:
Patent GB-1094301-A (GB)
Title: Improvements relating to anticoagulants
Inventor: REID HUGH ALISTAIR
IPC: A61K38/00
Filed: 1964-02-21
Abstract: An anti-coagulant enzyme is prepared from the venom of Ancistrodon Rhodostoma (the Malayan Pit Viper), by adsorption on, and stepwise elution from a weakly basic anion exchange resin. The enzyme is characterized by the following properties: (1) it is proteinaceous, and colourless when pure; (2) it is absorbable on weakly basic anion exchange materials (e.g. diethylaminoethyl- and triethylaminoethyl-cellulose); (3) it is soluble in physiological saline; (4) it has an electrophoretic mobility of 3.9 x 10-5 volts/cm/sec. in 0.1 M phosphate buffer at pH 7.0; (5) it has a M.W. not greater than 40,000 in monomeric form in the ultracentrifuge; (6) it has a sedimentation coefficient of 3.4 svedburgs at a concentration of 4.86 mgs/ml.; (7) it has a partial specific volume at this concentration of approximately 0.7; (8) it has thrombin-like defibrinating activity, but since the fibrin does not form a clot, it is anti-coagulant in vivo; (9) it is not inhibited by 1 x 10-3 molar diiso propyl fluorophosphate within 5 minutes.  The enzyme is prepared by adsorption of the venom on a column of one of the aforesaid anion exchangers, and eluted with buffers of stepwise increasing molarity, at pH 6.0, the enzyme coming off with 0.09 to 0.1 molar buffer.  The eluate may be freeze-dried or sterilized and rendered isotonic with physiological saline for use in pharmaceutical compositions (see Divisions A5-A6).  A method for the assay of its activity, by determination of its effect on the clotting time of blood, is described.ALSO:Anti-coagulant pharmaceutical compositions contain a purified, enzyme-containing preparation derived from the venom of Ancistrodon Rhodostoma (the Malayan Pit Viper) by chromatographic fractionation, which is substantially free from proteolytic enzymes which cause tissue and vascular necrosis.  The preparation is prepared by chromatographing the venom on a column of weakly basic (i.e. sufficiently weak not to cause protein denaturation) anion exchange material, such as dialkylamino alkyl polysaccharides, e.g. DEAE and TEAE cellulose; the adsorbed materials are eluted step-wise with buffer of increasing molarity, the active material coming off with about 0.09 to 0.1 M buffer at pH 6.0.  The solution may then be freeze-dried, or made isotonic with physiological saline and sterilized to provide an injectable composition.  This may be filled into ampules, or the reconstituted freeze-dried powder used, in unit dosage forms for intramuscular or intravenous injection.  The active enzyme may be obtained in the pure state, and is characterised in terms of its properties (see Division C3); it has thrombin-like de-fibrinating properties, but the fibrin produced does not form clots, and the enzyme is hence anticoagulant in vivo.
Patent GB-1339676-A (GB)
Title: Antibiotic and process for the production thereof
IPC: C07G11/00
Filed: 1972-02-16
Abstract: 1339676 The antibiotic SOB-7 CHUGAI SEIYAKU KK 16 Feb 1972 [24 Feb 1971] 7271/72 Heading C2A  An antibiotic SOB-7 is characterized in that it is a basic white hygroscopic amorphous powder and its hydrochloride and sulphate salts have melting points of 192-194‹ C. and 162- 164‹ C. respectively (with decomposition); the elementary analysis of the hydrochloride salt thereofis: C, 34À49-34À96%; H, 6À14-6À19%; N, 14À38-14À62%; and Cl, 21À53-21À58%; the empirical formula being C 14 H 27 N 5 O 7 .3HCl and the molecular weight being 486À5; the optical rotation of the hydrochloride and sulphate salts is [α]<SP>23À5</SP> D  = O in 1% aqueous solution; the ultraviolet absorption spectrum is as shown in Fig. 1, the hydrochloride and sulphate salts have infra-red absorption spectra as shown in Fig. 2 and Fig. 3 respectively and the sulphate salt has a nuclear magnetic resonance spectrum as shown in Fig. 4. The hydrochloride and sulphate salts of SOB-7 are easily soluble in water, soluble in methanol, sparingly soluble in ethanol and insoluble in other organic solvents, Rf values of its hydrochloride salt in thin layer chromatography on cellulose powder are 0À29 in n-butanol : pyridine : acetic acid : water (15 : 10 : 3 : 12 by volume), 0À20 in ethanol : water (1 : 1 by volume), 0À78 in 20% ammonium acetate : water (1 : by volume), 0À17 in nbutanol : acetic acid : water (2 : 1 : 1 by volume), 0À08 in nbutanol : pyridine : acetic acid : water (15 : 10 : 3 : 12 by volume) and 0À12 in the upper layer of chloroform : methanol : 14% aqueous ammonia (2 : 1 : 1 by volume) (last using silica gel G); it is positive in Ninhydrin and Sakaguili colour reactions but is negative in Molisch and Biuret colour reactions. A process for the production of an antibiotic SOB-7 comprises culturing an SOB-7 producing strain belonging to genus Streptomyces lavendulae ATCC 21655 in a chemically defined or natural nutrient medium which contains assimilable carbon sources, nitrogen sources, inorganic salts and a trace of growth factors with a substantial amount of the antibiotic SOB-7 is accumulated in the medium and isolating SOB-7 from the medium. Pharmaceutical compositions which contain SOB-7 in conjunction with a pharmaceutically acceptable diluent or carrier have been prepared.
Patent GB-589428-A (GB)
Title: Improvements in or relating to oiling means for the spindles of spinning mules
IPC: D01H7/20
Filed: 1945-03-23
Abstract: 589,428. Lubricating spinning spindles. FAIRCLOUGH, R., MILLER, N., and BALSHAW, W. M. March 23, 1945, No. 7356. [Class 120 (ii)] [Also in Group XXXIV] An oiling arrangement for mule spindles comprises a felt or similar absorbent strip A laid along the bolster plate C and having a hole for each spindle, and a cover plate D with corresponding holes and downturned flanges resting upon the felt. A recess is formed in one of the flanges near to each spindle for the passage of oil from the usual oil groove in the bolster plate C. The cover plate D is preferably fixed to the bolster by screws E, spacing collars e being provided. An oil-thrower ring b may be attached to each spindle to throw back on to the felt strip oil raised by rotation of the spindle.
Patent GB-142614-A (GB)
Title: Internal combustion engine
IPC: F01L5/02
Filed: 1919-03-25
Abstract: 142,614. Cheswright, L K., and Prieux, L. March 25, 1919. Valves; valve-gear. - In an engine having a separate compression chamber for receiving the charge prior to ignition, the cylinder A and the compression chamber C are intermittently put in communication by way of ports 4, 5 in slide valves F, G respectively, operated by cam-gear K from the crank-shaft L. The chamber C is in communication with the cylinder during the latter part of the compression stroke and during the outward movement of the piston on the firing stroke until the crank is about 30 degrees from the dead-centre. The charge is then ignited, communication between the cylinder and compression chamber being cut off during the expansion, exhaust, and suction strokes, and during the first part of the compression stroke, until the pressure in the cylinder is approximately equal to that in the auxiliary chamber. During the exhaust stroke, communication between the cylinder and exhaust pipe D is effected by way of ports 2, 1, 8, 9, and during the suction stroke between the cylinder and the induction pipe E by way of ports 2, 1 ,3. Lubrication of the valves is effected by oil supplied to a duct Q by a pump P. In a modification, the auxiliary compression chamber is formed as a cavity in the valve G.
Patent GB-886554-A (GB)
Title: Pallet tiering frames
IPC: B65D19/38
Filed: 1959-03-04
Abstract: 886,554. Tiering frames for pallets. ARROWHEAD PRODUCTS Inc. March 4, 1959 [March 10, 1958], No. 7464/59. Class 78 (4). The uprights 7 (Fig. 1) of a two-part tiering frame are arranged to fall outside the bearing area of the pallet on which the frame is mounted and each is connected to the pallet by a twoarmed bracket 14, 15 (Fig. 3) embracing the stringer 2 or other means joining the decks of the pallet. Each upright may be secured to the web 16 of the bracket, as shown in Fig. 3, or to the outside arm 14. The depth of the bracket 14, 15 preferably allows the upright 7 to move relatively to the pallet between a position in which a semi-tubular foot 17 is flush with the base of the pallet, when this is standing on the floor, and a position in which the foot 17 is below the base of the pallet so that it can embrace an upper rail 6 (Fig. 1) of a pallet below in a stack. As shown, the upper rails 6 are joined by ends 13, which need not be parallel to the deck of the pallet, and which take into holes 13<SP>1</SP>.
Patent GB-1442038-A (GB)
Title: Electric cartridge fuse
IPC: H01H85/165
Filed: 1974-02-19
Abstract: 1442038 Fusible cut-outs NEG PRODUCTS (FRINTON) Ltd 30 Sept 1974 [19 Feb 1974] 7486/74 Heading H2G An electric cartridge fuse has the fuse wire 13, extending in an external groove 11 in the fuse body 10, which is made of synthetic plastics material, e.g. Arnite (Registered Trade Mark). The fuse wire is of smaller diameter than the depth of the groove at its ends and the metal end caps 14 clamp the wire on the body end faces. The fuse rating is displayed in a recess diametrically opposite the groove. The groove 11 may be formed as a helix, the recess being shorter or also helical, so as not to intersect the groove.
Patent GB-817116-A (GB)
Title: Improvements in or relating to display stands
Inventor: LATES STANLEY ALAN
IPC: A47F5/02
Filed: 1957-03-07
Abstract: 817,116. Display stands. WHITMARLEY ENGINEERING CO. Ltd. March 5, 1958 [March 7, 1957], No. 7547/57. Class 52(3) A display stand for articles such as gramophone records consists of holders for the records which can be hinged to a pillar and locked in place, the holders being so constructed that they cannot be opened as long as they are mounted on the pillar. As shown, several carrriers A are mounted on a pillar 10, each carrier comprising a sleeve and top and bottom plates 13, 12 each having a peripheral line of apertures which receive depending top and bottom hinge pins 28, 29 of a record holder 19 shown in Fig. 3. Pins 28, 29 are mounted on different halves 20, 24 of the holder made of wire, the halves being hinged together at 23. Thus after insertion of the record and hinging of the holder to the carrier plates 12, 13 the holder cannot be opened. An upper plate 15 prevents removal of the holders. The carriers are locked on the pillar by clamping means 17 at the top. An alternative holder, Fig. 6, consists of a box-like wire frame 31, 32 having at its open end hinge pins 36, 37 and a pivoted gate 34 which cannot be opened while the holder is on the carrier.
Patent GB-1491636-A (GB)
Title: Process for preparing p-vinylphenol polymer
IPC: C08F12/00
Filed: 1976-02-26
Abstract: 1491636 Preparing p-vinylphenol polymers and foams thereof MARUZEN OIL CO Ltd 26 Feb 1976 [1 March 1975] 07566/76 Headings C3P and C3C High purity p-vinylphenol polymers are prepared by (a) dehydrogenating crude p-ethylphenol containing the m- and/or o-isomers as impurities to form a vinyl phenol product, (b) polymerizing the crude product without purification, and (c) purifying the polymerization product. The p-vinylphenol monomer is stated to polymerize selectively in step (b) and the unreacted m- and/or o-vinylphenols are removed with other impurities in step (c). Polymerization may be effected by a thermal or cationic technique in the presence of a diluent; in the former method the diluent is preferably crude p-ethylphenol and in the latter a Friedel-Crafts or acidic catalyst is suitably used. In step (c) purification is preferably effected by distillation or film evaporation to remove the impurities from the polymer, or by precipitating the polymer from the reaction product, or a solution thereof, by means of a non-solvent for the polymer, e.g. a liquid hydrocarbon or halohydrocarbon. In Example 8, the precipitation procedure yields a porous product.
Patent GB-671455-A (GB)
Title: Improvements in micro-projection apparatus
IPC: G03B21/10
Filed: 1947-03-19
Abstract: 671,455. Two-part couplings. WEISKOPF, E. C. March 19, 1947, No. 7593/47. Class 38 (i). [Also in Groups XI, XIII, XX and XL (a)] An electric distribution box 324, Fig. 18, for supplying high or low voltages to a lamp housing 62 with which it is connected is supplied with current at low voltage through a detachable plug 328. The box includes a chamber 334 enclosing prong high-voltage terminals 338 and socket low-voltage terminals 336 in a block 332; the box also has several low voltage terminals 340 which together with terminals 336 are connected in parallel with the input terminals to which plug 328 is attached. The terminals 338, 336 are engageable by a plug 346, Fig. 25, which comprises an integral block 350 having prong low-voltage terminals 354 and socket high-voltage terminals 356, respectively connected with cables 342, 344. A pair of clasp members 358 pivoted on the box 324 co-operate with a pair of catch members 360 on the plug 346 to hold the latter in position.
Patent GB-1385655-A (GB)
Title: Tethered ball game
IPC: A63B67/10
Filed: 1973-02-16
Abstract: 1385655 Table ball game AURORA PRODUCTS CORP 16 Feb 1973 7652/73 Heading A6H A table ball game has a circular base 10 with centrally located ball-receiving apertures 14. An impact-transfer apparatus, which acts as a ball projector can rotate 360‹ about the base 10 in a groove 36 which may also be used for ball storage). The impact-transfer apparatus comprises a stationary ball 74, an impact ball 70 suspended from a support by a tether, and a projectile ball 80 receiving cup (not shown in Fig. 1). The cup can be pivoted horizontally to aim the projectile ball 80.
Patent GB-415826-A (GB)
Title: Improvements relating to control mechanism for fluid-operated valves
IPC: F15B13/06
Filed: 1933-03-15
Abstract: 415,826. Engine valve-gear. STEPHEN & SONS, Ltd., A., BROWN, T. W. F., and GRANGE, G. R., Linthouse, Govan, Renfrewshire. March 15, 1933, No. 7793. Addition to 388,217. [Class 122 (ii).] In a timing-device of the kind described in the parent Specification, the diametricallyarranged passage through the control plug and the arrangement of ports and connections to the pump suction and discharge and to and from the valve-control cylinders, which ports and connections are arranged in a single transverse plane, are replaced by a plug with an oblique diametrical passage, or with two transverse passages, and by ports and connections arranged in two planes. The rotary plug 23 has ports X, Y connected by a passage 25 which control the connections between ports a-d and a<1>-d<1>. The ports a, a<1> are connected to the oil pump discharge, and the ports d, d<1> to the suction. The ports b, b<1> are connected to the supply of the valve-control cylinders, and the ports c, c<1>, to their exhausts. In the modification with two transverse passages in different planes, the passages are arranged at right angles.
Patent GB-547966-A (GB)
Title: Manufacture of ªÐ-aminobenzene sulphone ªú¼ª-dimethyl acrylic acid amide
IPC: C07C311/37
Filed: 1941-06-20
Abstract: 547,966. Sulphonamides. GEIGY AKT.- GES., J.R. June 20,1941, No. 7794. Convention date, June 21, 1940. [Class 2 (iii)] p-Aminobenzenesulphon- #:#-dimethylacrylic acid amide is prepared by reacting benzenesulphonamide or its salt having in p-position a nitrogen-containing group with #:#-dimethylacrylic acid or a functional derivative thereof, and converting the nitrogen-containing group into the amino group. The product possesses enhanced therapeutic' properties. Examples are given of the preparation of the amide by (1) heating p-acetylaminobenzenesulphonamide with dimethylacrylic acid anhydride, or with dimethylacrylic acid and phosphorus pentoxide, and splitting off the acetyl group with caustic soda solution ; (2) treating p-nitrobenzenesulphonamide with dimethylacrylic acid and phosphorus pentachloride, or the sodium compound of the sulphonamide with dimethylacrylic acid chloride, and reducing by BÚchamp's method; (3) boiling p-acetylaminobenzenesulphonamide with dimethylacrylic acid chloride under reflux, and hydrolysing with caustic soda solution; (4) heating 4-carbethoxyaminobenzenesulphonamide with dimethylacrylic acid chloride and splitting off the carbethoxy group with caustic soda solution; the carbomethoxy compound may also be used. Specification 541,958 is referred to. The Specification as open to inspection under Sect. 91 also refers to products in which the p-amino group is substituted by alkyl or aralkyl groups, said products being obtained from alkyl- and aralkyl-amino-benzenesulphonamides. It further describes the preparation of these products and the p-amino product by reacting benzene-sulphohalides having a nitrogen-containing group in the p-position with #:#-dimethylacrylic acid amide and converting the nitrogen-containing group, if necessary, into the amino group. This subject-matter does not appear in the Specification as accepted.
Patent GB-1458267-A (GB)
Title: Selentium-containing steroids and their use in organ visualisation
IPC: A61K51/04
Filed: 1974-02-20
Abstract: 1458267 Visualizing the adrenal gland of a mammal RADIOCHEMICAL CENTRE Ltd 10 Feb 1975 [20 Feb 1974] 7808/74 Heading A5B [Also in Division C2] Pharmaceutical compositions for parenteral administration comprise a carrier and a steroid of formula: wherein X is H or acyl, Y is alkyl, n is 0 or 1, and the Se comprises <SP>75</SP>Se. A process for "visualising" the adrenal glands of a mammal comprises administering a compound I, allowing it to concentrate in the adrenal glands, and observing the radiation emitted therefrom.
Patent GB-266153-A (GB)
Title: Improvements in and connected with louvre ventilators
IPC: E06B7/084
Filed: 1926-03-22
Abstract: 266,153. Mead, A. A., and Mead, McLean, & Co., Ltd. March 22, 1926. Valves anci valve apparatus.-A louvre ventilator comprising strips a of glass or other material mounted at the ends in pivoted shoes b, c, which are adapted to be swivelled simultaneously by means of lugs e pivotally engaged with a sliding bar f, is provided with an operating handle g mounted in projections e<1> formed on a lug of one of the pivoted shoes. The handle g is raised to horizontal position in order to operate the louvres, but normally hangs downwardly, being prevented from contacting with the louvre by means of a projection g<2> adapted to engage an abutment on the corresponding lug. In the construction shown in Figs. 1 and 3, the frame bar h at the top of the ventilator is formed on its undersurface with a groove i for receiving the bar f. Pins k on the bar f engage slots in the lugs e. The groove i may alternatively be constituted by a slotted strip arranged below the frame bar. In a further modification, Fig. 5, the bar f may be pivoted at f<1> to the lugs e and operation of the handle g imparts a parallel ruler motion to the bar. The bar f is arranged to slide in a recess in the frame bar. The lower frame member may be provided with a stiffening flange, and the upper and lower frame members may be connected by a post l as shown in Fig. 5. A blade spring m located in a recess in the upper surface of the bar h may be arranged to engage in one of a series of three notches in the upper surface of the sliding bar f in order to lock the louvres in adjusted position.
Patent GB-338468-A (GB)
Title: Alumino-thermic process for the generation of highest temperatures
IPC: F24J3/00
Filed: 1930-03-11
Abstract: 338,468. Bl³mner, E. March 11, 1930. Heating by chemical action. - In an aluminothermal process, very high temperatures are obtained by employing one or both components in molten state. Iron oxide is placed in an annular vessel b and aluminium in a vessel c. An outer vessel a contains an alumino thermal mixture which may be ignited electrically or by a fuse i. The vessel a is surrounded by insulating material and is placed in a closed pressure-resisting container which is placed in a vessel of water. When the mixture h is ignited, the iron oxide f and aluminium d are successively melted, and the aluminium expands, melts a fusible plug g, and overflows into the iron oxide. The resulting high temperature commences to melt the wall of the vessel c, which may be of alumina, and the melting continues as the reaction proceeds. Nitrogen at a pressure of 200 atmospheres may be supplied to the container in which the vessel a is placed.
Patent GB-517507-A (GB)
Title: Improvements in and relating to radiators for internal combustion engines
IPC: F28D1/02
Filed: 1939-03-13
Abstract: 517,507. Radiators for internal-combustion engines. DELANEY, C. T. BELAIEFF, J. F., GEORGE, W. L., and GALLAY, Ltd. March 13, 1939, No. 7990. [Class 64,(iii)] Armour portions a at the entrances to air channels c protect from gunfire the radiator elements b, and the tanks e provided at both ends of the elements, of a radiator of V- or W- cross-section. Bullets striking the portions a will ricochet, while those entering the air channel c will pass straight down or ricochet down to the inner end of the V- or W-section. d is a cap of soft metal, rubber &c., in which each bullet will leave only a single small hole which will . not affect the air-pressure through the elements b. In a modification, the elements b are parallel.
Patent GB-330602-A (GB)
Title: The manufacture of new dyestuffs and the application thereof
IPC: C09B51/00
Filed: 1929-03-12
Abstract: 330,602. British Celanese, Ltd., and Olpin, H. C. March 12, 1929. Naphthalene, dyes derived from; dye preparations. - N-nitroaryl-ar-tetrahydro-a- or #- naphthylamines for dyeing cellulose esters and ethers are made by condensing ar-tetrahydro-a- or #-naphthylamine or derivatives thereof, with nitrated aromatic compounds containing one or more labile halogen atoms, e.g. 2-nitro- or 2 : 4- dinitrochlorbenzene, o-nitrobrombenzene, 2:5- dichlornitrobenzene, 2 : 4-dinitrochlorbenzene-6- sulphonic or 6- carboxylic acid. The compositions containing the insoluble dyestuffs and a dispersator and/or protective colloid are referred to. The dispersators of Specifications 219,349, 224,925, 242,393, 242,711, 269,960, 273,819, 273,820, 322,737 and 323,788 may be used. In examples, (1) 2 : 4-dinitrophenyl-ar-tetrahydro-a-naphthyl. amine is made from ar-tetrahydro-a-naphthylamine and 2 : 4-dinitrochlorbenzene; (2) ar-tetrahydro-#-naphthylamine is condensed with 2 :5- dichlornitrobenzene. The following are also specified : 2 : 4 - dinitrophenyl - artetrahydro - #- naphthylamine, 2 : 4-dinitro-6-sulphonaphthylamine, 2 - nitro - 4 - chlorphenyl-ar-tetrahydro-#- naphthylamine.
Patent GB-570177-A (GB)
Title: Athletic supporter or suspensory
IPC: A61F5/40
Filed: 1943-05-21
Abstract: 570,177. Athletic suspensories. MONTMARQUET, F. H. May 21, 1943, No. 8081. Convention date, June 19, 1942. [Class 81 (ii)] An athletic suspensory comprises a waistband of relatively wide webbing, at least a part of which may be of elastic material, the frontal portion of which is defined by angularly directed branches 13, 14, lying substantially parallel to the groin, outlining a continuous common edge 15, which may be formed by a mitre fold in the waistband, to which the upper edge of a sack 27 is affixed, leg straps 34, 35 connecting the lower portion of the sack to the waistband. The common edge 15 may not extend the full width of the sack. The usual opening may be provided in the sack. In a modification, the front of the sack is formed as a double-walled pocket containing a protective cup.
Patent GB-1010936-A (GB)
Title: Improvements in or relating to folding cartons
Inventor: FOYLE JOHN ROLAND
IPC: B65D5/36
Filed: 1963-03-01
Abstract: 1,010,936. Cartons. BOX FOLDIA Ltd. Feb. 28, 1964 [March 1, 1963], No. 8214/63. Heading B8P. The blank shown in Fig. 1 is folded, as shown in Fig. 3, to form a self-erecting carton, with the panels 19a, 23 (Fig. 1), adhered to the inner faces of gussets 15 and with the panels 19d adhered to the inner faces of the wall panels 17. To erect the carton, side walls 17 are pulled away from each other until the walls are upright, the corner reinforcements to facilitate stacking taking either the shape of a rectangular piller (Fig. 4), or being flat-folded with double thickness configuration (Fig. 6).