baber/WOPTO huggingface dataset:
Patent AT-E254711-T1 (AT)
Inventor: SOMMER HANS-RUDOLF
IPC: A47L9/00
Filed: 1999-09-04
Granted: 2003-12-15
Abstract: Motors are provided for left and right-hand side movement mechanism parts. A control device controls the movement mechanism with front and rear side contact devices for production of control signals in the event of the cleaning unit (2) coming into contact with the swimming pool wall (3) or an obstruction. The control device for each movement mechanism part has a speed regulating device and equipment for a differential control of the speed of the two motors. The cleaning unit on both movement mechanism parts has devices for measurement of the distances (d1,d2) covered during the backward and forward movement. The control device calculates the direction alteration angle (R1,R2) for the moving cleaning unit on the basis of the measured covered distances. The control device also calculates a width (v) of the movement path and controls it differentially.
Patent AT-E401649-T1 (AT)
Inventor: HATTORI KYOHJI
IPC: G11B7/00
Filed: 1999-12-23
Granted: 2008-08-15
Abstract: A method of initializing a phase-change optical information recording medium is provided, using an optical system incorporating a semiconductor laser device. The laser device is characterized by a specified spatial power distribution. In a spatial distribution of the laser power focused on the recording medium in the direction perpendicular to guide tracks, the laser device preferably has an average smaller in both end regions of the spatial distribution, which have each 10% of the width at half maximum of the distribution, than the average in the center region of the full width at half maximum of the distribution. <IMAGE>
Patent AT-E203655-T1 (AT)
Inventor: CERVERA PALOMARES VICENTE D
IPC: A47J36/16
Filed: 1999-03-04
Granted: 2001-08-15
Abstract: The food processor has an outside container (3) and an inside container (4) between which there is thermal-acoustic insulation (6), there being in the bottom part of the inside container (4) food heating means and this inside container (4) receiving a beater container (5) provided in its bottom with the corresponding blades (7) connectable to a motor (9) that is surrounded by an acoustic insulation; thus providing very silent operation, the impossibility that the user thereof is burnt and the option to use same as a thermos flask. Other important characteristics consist of some controls with very leak-proof buttons (21 and 23), some special legs (26) that insulate against vibrations and a safety device that prevents the motor (9) from operating without the double cover (14) being put on and prevents removal of said cover (14) when the motor (9) is operating. <IMAGE>
Patent AT-E474299-T1 (AT)
Inventor: SANDEI PIETRO
IPC: G07F13/06
Filed: 1999-04-03
Granted: 2010-07-15
Abstract: The dispenser comprises a plurality of delivery stations (20, 30) for the constituent substances of the drink, a delivery station (40) for empty cups, a location (10) for release of the drink to the user, and an automatic control unit which automatically controls the succession of operations involved in emitting the substances and cups. A cup handling device (60) is provided, comprising a gripping member (61) for gripping a cup (8), and means for moving said gripping member (61) in such a manner as to bring it, by a succession of movements, to the exit points of the delivery stations (20, 30, 40, 50); said handling device (60) is controlled by the automatic control unit in such a manner as to firstly bring the gripping member (61) to the station (40), then bring the gripped cup under the exit points of the other delivery stations (20, 30, 50), and finally bring the cup carrying the drink into the location (10) for its release to the user. <IMAGE>
Patent AT-E259110-T1 (AT)
Inventor: SHYU SHYI-HWANG
IPC: F16L1/26
Filed: 1999-08-05
Granted: 2004-02-15
Abstract: A cable junction is provided for connecting two optical cables (110) submerged underwater, having a casing (130), an anchorage (120), a casing loading ring (150), an anchorage loading ring (145) and a seal ring (140). The casing (130) has a casing sealing surface (153). The anchorage (120) is arranged in the casing (130), and has an anchorage sealing surface (157). Circular ridges (260, 263) are provided in the casing sealing surface (153) and the anchorage sealing surface (157), respectively, for embedding into the seal ring (140). The anchorage (120) is rotatably coupled to the casing (130) by an anchorage/casing threaded joint (133). The casing loading ring (150) has a casing loading ring sealing surface (150a). The anchorage loading ring (145) has an anchorage loading ring sealing surface (145a). The seal ring (140) is arranged between the casing sealing surface (153) and the casing loading ring sealing surface (150a), and also arranged between the anchorage sealing surface (157) and the anchorage loading ring sealing surface (145a) for preventing hydrogen from entering the cable junction. The seal ring (140) is preferably made from a metal material such as copper, however, the scope of the invention is not intended to be limited to any particular material. <IMAGE>
Patent AT-E228422-T1 (AT)
Inventor: GARCIA LEAL JOSE ANTONIO
IPC: B29C45/00
Filed: 1999-07-23
Granted: 2002-12-15
Abstract: Consists of a construction of a joint mold for pail (1) and handle (1.1) in two different horizontal coplanar parts, the upper part (2) and the lower part (3), from a point of view of the use of the pail and not from the injection of plastic, either from a new mold or by adapting an existing conventional mold from the molds used only for making pails (1).  <IMAGE>
Patent AT-E237019-T1 (AT)
Inventor: BURKINSHAW STEPHEN MARTIN
IPC: D06B3/28
Filed: 1999-02-02
Granted: 2003-04-15
Abstract: A method for dyeing and finishing a lyocell fabric or polynosic fabric includes the steps of dyeing the fabric with a reactive dyestuff under conditions such that primary fibrils are formed; removing the primary fibrils from the fabric by treatment with a solution of a cellulase; heating the solution to both denature the cellulase and induce secondary fibrillation; and drying the fabric. The method offers the advantages of low liquor usage and shortp rocessing time.
Patent AT-E209912-T1 (AT)
Inventor: ARTH CHRISTOPH
IPC: A61K47/32
Filed: 1999-03-16
Granted: 2001-12-15
Abstract: A transdermal therapeutic system (TTS) for transcutaneous administration of oxybutynin over a period of several days, in addition to a method for the production of the TTS without the use of solvents, are disclosed. The TTS contains a matrix mass containing oxybutynin in the form of a self-adhesive layer. The matrix mass includes ammonium-group-containing (meth)acrylic polymers, at least one citric acid ester, and 5-25 wt. % oxybutynin.
Patent AT-E531376-T1 (AT)
Inventor: SECRIST JOHN
IPC: C07H19/06
Filed: 1999-07-23
Granted: 2011-11-15
Abstract: Patients suffering from cancer are treated by being administered a compound represented by formula: (1), wherein each R individually is H or an aliphatic or aromatic acyl group; A is selected from the group consisting of formulae (IIa, IIb, IIc, IId), wherein X is selected from the group consisting of hydrogen, fluorine, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano and nitro. The above compounds also inhibit DNA replication in mammalian cells.
Patent AT-E244008-T1 (AT)
Inventor: KOSHIKA TADATSURA
IPC: C07D498/18
Filed: 1999-03-04
Granted: 2003-07-15
Abstract: Macrolide compounds, such as the FK506 Substance and its related compounds are provided for the prevention or treatment of adult respiratory distress syndrome. Composition containing such compounds is also disclosed.
Patent AT-E280204-T1 (AT)
Inventor: HONDA KENJI
IPC: G03F7/42
Filed: 1999-08-05
Granted: 2004-11-15
Abstract: A non-corrosive photoresist stripping and cleaning composition, comprising:(a) about 5% to about 50% of a solvent;(b) about 10% to about 90% of an alkanolamine;(c) about 0.1 to 10 % of a carboxylic acid; and(d) about 1.0% to 40% of water.
Patent AT-E283138-T1 (AT)
Inventor: NEILL DAVID
IPC: B21J5/00
Filed: 1999-08-27
Granted: 2004-12-15
Abstract: A process for producing clad pipe comprises forming a hollow body (S10) of base material, bonding a cladding material metallurgically to the base material (S12) to form a composite body and subsequently extruding the composite body to form a pipe. This process allows the metallurgical bond to be validated using non-destructive methods prior to extrusion. Any areas that are unbonded will be detected, thereby reducing wastage. Moreover, because the metallurgical bond is achieved prior to extrusion, the cladding thickness is controlled during the extrusion process, avoiding migration of the clad material into the base material by disproportionate amounts.
Patent AT-E283271-T1 (AT)
Inventor: LOVE WILLIAM GUY
IPC: A61F9/007
Filed: 1999-08-31
Granted: 2004-12-15
Abstract: There is provided a compound of formula (I), wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8>, R<9>, X, Y<1>, Y<2>, Y<3>, Z, M, A-B and C-D have meanings given in the description, which are useful in the treatment of medical conditions for which a photodynamic compound is indicated. Compositions, apparatus and methods of treatment of a medical condition for which a photodynamic compound is indicated are also disclosed.
Patent AT-E243138-T1 (AT)
Inventor: BOUKREDINE ERIC
IPC: B65D5/46
Filed: 1999-08-30
Granted: 2003-07-15
Abstract: A carton and blank (10) for forming a carton for beverage containers which carton includes a series of hinged panels (12, 14, 16, 18, 20, 22) forming a sleeve and end closure panels (34, 36, 38, 40) hinged to at least one associated hinged panel (12, 14, 16, 18, 20, 22) for closing, at least in part, the opposite ends of a sleeve. The said carton includes handle means by which the carton can be carried, said handle means comprising a strap (38) connected to opposed end panels (38, 40) having a user part (74) which is in substantially co-planar relationship with said one hinged panel (18) when in a stored condition. The strap (98) is so connected at its opposite ends to said end closure panels (38, 40) as to provide a surplus of material to enable said user part to be brought into a position of use.
Patent AT-E260645-T1 (AT)
Inventor: KANIKANTI VENKATA
IPC: A61K9/54
Filed: 1999-09-17
Granted: 2004-03-15
Abstract: The present invention relates to orally administrable multiple-unit sustained-release dose forms having controlled agitation-independent release of active compound and processes for their production using a selected erodable hydrophilic polymer (HPC) and a limitation of the maximum size of the active compound-containing polymer particles to <=3 MM.
Patent AT-E270795-T1 (AT)
Inventor: HEWITT ERIC
IPC: G06F11/10
Filed: 1999-09-27
Granted: 2004-07-15
Abstract: A method for decoding a linear block encoded string of information bits comprises the steps of receiving the linear block encoded string of information bits and converting the string into codewords, performing hard and soft decisions on each codeword in order to generate a hard decision vector, computing the syndrome of the hard decision vector, computing the I bit parity of the hard decision vector h, and performing error correction if necessary. <IMAGE>
Patent AT-E245518-T1 (AT)
Inventor: BELTRANDI DARIO
IPC: B29C33/30
Filed: 1999-11-15
Granted: 2003-08-15
Abstract: A mold for manufacturing plastic items, composed of a female mold half and of a male mold half which are mutually aligned along a vertical axis, the male mold half being composed of a sleeve and a plug which is guided inside the sleeve and is movable with respect thereto; the female mold half comprises a base plate, a bush which is guided on the base plate and forms, together with the base plate, a cavity for receiving a dose of plastic material to be molded, the bush being provided with an abutment which acts as a locator for the sleeve during molding, the bush being movable with respect to the base plate in contrast with elastic return means which allow the plug to enter said cavity.
Patent AT-E314726-T1 (AT)
Inventor: VOGEL MARTIN
IPC: G06F3/02
Filed: 1999-10-21
Granted: 2006-01-15
Abstract: The invention relates to a device for entering values by using a display screen provided for displaying the values and by using at least one element for manually entering values. The device includes a support for the element which is connected to the display screen upstream in a viewing direction. The support includes at least one transparent area which is assigned to the element.
Patent DE-07747618-T1 (DE)
Title: Verfahren und vorrichtung für die wartung von hochspannungs-schalteinrichtungen unter spannung
Inventor: MIKKELSEN PER
IPC: H02B11/24
Filed: 2007-05-04
Abstract: Vorrichtung für die Wartung von Hochspannungs-Schalteinrichtungen/Sicherungen in einer Anlage,  dadurch gekennzeichnet, dass die Vorrichtung Abschirmplatten (20A–C) aufweist, die vorzugsweise aus PVC hergestellt sind, und vorzugsweise eine im wesentlichen rechteckige Form haben, wobei die Abschirmplatten (20A–C) versehen sind mit  – Mitteln (22, 25) zum Einschieben und Anordnen der Abschirmplatten (20A–C) in eine bzw. einer Schalteinrichtungszelle,  – Mitteln (23, 24) zum Befestigen der Abschirmplatten (20A–C) an der Schalteinrichtungszelle/Anlage, und  – Mitteln (27; 28A–B) für den Anschluss eines Bypasses über der Schalteinrichtung/den Sicherungen.
Patent DE-452162-T1 (DE)
IPC: B65H75/44
Filed: 1991-02-21
Abstract: Linear identification means, characterised in that it consists of concealed identifications such as (14a) (14b), embedded in the thickness of the wall of a flexible article of long length, such as the flexible pipe (hose) (4), which is composite and of prismatic or cylindrical shape, in order to create, during the reading by suitable sensors, a perturbation of the dynamic magnetic field detected. 
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Patent ES-2164620-T1 (ES)
Inventor: SUHR PATRICK
IPC: C02F11/06
Filed: 2000-05-24
Abstract: An apparatus injects sludge into a combustion chamber via a manifold connected to small diameter tubular injectors extending through thermal insulation of the chamber. The injectors are regularly spaced and arranged in groups across the chamber. A supply pipe connects to the middle of the manifold located near a mid point of the length of the chamber. Preferred Features: The apparatus may have more than one manifold. Each manifold may be in three parts joined together by dilation compensators and, optionally, isolation valves. The supply pipe connects to the middle or an end part of the manifold. Each part has an associated group of injectors. The apparatus handles sludge at 50-250 kg/hour.
Patent ES-2201950-T1 (ES)
Inventor: DOMEL DOUGLAS R
IPC: E06B9/322
Filed: 2003-01-31
Abstract: The motorized window covering comprises a remote control unit (34) provided with means (202) for transmitting signals and an actuator coupled to the window covering and provided with means (204, 205, 206, 208) for receiving signals. It is characterized in that the means for receiving signals comprise means for receiving a wake-up signal (205, 208) and means for receiving a data signal (204, 206). Such a motorized window covering conserves powers. The invention further relates to a method for controlling the motorized window covering. <IMAGE>
Patent ES-2239934-T1 (ES)
Title: Procedimiento de mando de la activacion de un accionador electromecanico.
Inventor: SYMOEN LIONEL
IPC: H04B3/54
Filed: 2003-09-15
Abstract: Procedimiento de mando de la activación de uno o varios accionadores electromecánicos (27, 37) que controlan en diferentes sentidos de desplazamiento un equipo móvil del edificio (28, 38) con intermedio de un emisor de instrucciones (10, 20, 30; 20¿) y de un receptor de instrucciones (26, 36; 26¿) situadas, respectivamente, una de ellas más arriba de la otra en la línea de alimentación eléctrica del dispositivo accionador de corriente alterna monofásica, una orden de activación que comprende una sucesión temporal entre el emisor de órdenes (10, 20, 30; 20¿) y el receptor de órdenes (26, 36; 26¿), de un número entero de semiperíodos durante los cuales la línea está abierta, y un número entero de semiperíodos durante los cuales la línea está cerrada, caracterizado porque una orden de paro consiste en una apertura de la línea durante un tiempo estrictamente superior a un semiperíodo, seguido de un cierre de la línea.
Patent ES-2438941-T1 (ES)
Inventor: MOHR JORG-THORSTEN
IPC: C07J53/00
Filed: 1997-08-11
Abstract: Production of drospirenone (6beta ,7beta ;15beta ,16beta -dimethylene-3-oxo-17alpha -pregn-4-ene-21,17-carbolactone) of formula (I) comprises catalytically hydrogenating 17alpha -(3-hydroxy-1-propynyl)-6beta ,7beta ;15beta ,16beta -dimethylene-5beta -androstane-3beta ,5,17beta -triol of formula (II) to give 17alpha -(3-hydroxypropyl)-6beta ,7beta ;15beta ,16beta -dimethylene-5beta -androstane-3beta ,5,17beta -triol of formula (III), oxidising (III) in the presence of a ruthenium salt to give 6beta ,7beta ;15beta ,16beta -dimethylene-5beta -hydroxy-3-oxo-17alpha -pregnane-21,17-carbolactone of formula (IV), and dehydrating (IV): Also claimed are intermediates (III) and (IV).
Patent ES-2027942-T1 (ES)
IPC: A61H33/02
Filed: 1990-07-23
Abstract: The mat consists simply of a rigid or semi-rigid sheet (12) provided with a series of nozzles (14) and surrounded by a peripheral skirt (20) forming, with the sheet of the mat, a hollow volume (18) in which there is established, during operation, a flat gas bubble below the surface of the nozzles. <IMAGE>
Patent CY-1109743-T1 (CY)
Inventor: EL-AHMAD YOUSSEF
IPC: A61K31/4188
Filed: 2010-01-20
Abstract: The present invention is related to a compound of formula (I) wherein R1, R2, R3, R4 and X are as defined herein, or an acid-addition salt thereof, its preparation and therapeutic use in the treatment or prevention of diseases involving the Nurr-1 nuclear receptors, also known as NR4A2, NOT, TINUR, RNR-1 and HZF3.
Patent CY-1114308-T1 (CY)
Title: Παραγωγα της 3-αλκυλο-5-(4-αλκυλ-5-οξο-τετραϋδροφουραν-2-υλο)πυρρολιδιν-2-ονης ως ενδιαμεσες ενωσεις στη συνθεση των υποδοχεων της ρενινης
Inventor: SEDELMEIER GOTTFRIED
IPC: C07F1/02
Filed: 2013-09-02
Abstract: Η εφεύρεση σχετίζεται με μία νέα διαδικασία, νέα στάδια της διαδικασίας και νέες ενδιάμεσες ενώσεις που χρησιμεύουν στη σύνθεση φαρμακευτικώς δραστικών ενώσεων, ιδίως των αναστολέων της ρενίνης, όπως της αλισκιρένης. Μεταξύ άλλων, η εφεύρεση σχετίζεται με μία διαδικασία για τη βιομηχανική παρασκευή μίας ένωσης με τον τύπο II ή ενός άλατος της ένωσης αυτής και μίας ένωσης με τον τύπο VI ή ενός άλατος της ένωσης αυτής, όπου το R3 και το R4 καθώς και το Αct είναι όπως ορίζονται στην περιγραφή, καθώς και με διαδικασίες για τη βιομηχανική παρασκευή τους. Επιπλέον ο μετασχηματισμός των ενώσεων (VI) με μεταλλο-οργανικές ενώσεις (VII) δημιουργεί νέες ενώσεις (VΜΙ) οι οποίες είναι άμεσες πρόδρομες ενώσεις για την παρασκευή της Αλισκιρένης.
Patent CY-1114456-T1 (CY)
Title: Αναστολεις ιικης πολυμερασης
Inventor: TSANTRIZOS YOULA S
IPC: C07D401/12
Filed: 2013-10-04
Abstract: Ένα εναντιομερές, διαστερεομερές ή ταυτομερές μίας ενώσεως, που αναπαρίσταται από τον τύπο (Ι): όπου είτε το Α είτε το Β είναι άζωτο και το άλλο Β ή Α είναι C και οι ρίζες R1, R2, R3, R4, R5, R6, R7, R8, R9 και R10 είναι όπως ορίζεται στο παρόν, ή ένα άλας ή ένας εστέρας αυτής ως αναστολείς ιικής πολυμεράσης. Η ένωση χρησιμοποιείται ως αναστολέας RΝΑ πολυμερασών εξαρτώμενων από RΝΑ, συγκεκριμένα εκείνων των ιικών πολυμερασών εντός της οικογένειας Flaviviridae, πιο συγκεκριμένα ΗCV πολυμεράσης.
Patent CY-1116513-T1 (CY)
Title: Παραγωγα πιπεριδινονης ως αναστολεις της mdm2 για τη θεραπευτικη αγωγη του καρκινου
Inventor: BARTBERGER MICHAEL DAVID
IPC: C07D401/06
Filed: 2015-07-17
Abstract: Η παρούσα εφεύρεση παρέχει ενώσεις αναστολέων της MDM2 Τύπου (I), με τις σχετικές μεταβλητές να ορίζονται πιο πάνω, οι οποίες ενώσεις είναι χρήσιμες ως θεραπευτικοί παράγοντες, συγκεκριμένα για τη θεραπευτική αγωγή καρκίνων. Η παρούσα εφεύρεση σχετίζεται επίσης με φαρμακευτικές συνθέσεις που περιέχουν αναστολέα της MDM2.
Patent CY-1117288-T1 (CY)
Title: Παραγωγα 2-οξο-1-πυρρολιδινυλ ιμιδαζοθειαδιαζολης
Inventor: QUESNEL YANNICK
IPC: C07D513/04
Filed: 2016-03-15
Abstract: Η παρούσα εφεύρεση σχετίζεται με παράγωγα 2-οξο-1-πυρρολιδινο ιμιδαζοθειαδιαζόλης, με διαδικασίες για την παρασκευή τους, με φαρμακευτικές συνθέσεις που τα περιέχουν και με τη χρήση τους ως φαρμακευτικά σκευάσματα.
Patent CY-1117627-T1 (CY)
Title: Διαταξεις βελονας για αυτοματους εγχυτηρες υγρου/ ξηρου περιεχομενου
Inventor: GRIFFITHS STEVEN M
IPC: A61M5/34
Filed: 2016-05-09
Abstract: Μια άποψη είναι σχετική με μια συσκευή αυτόματης έγχυσης που περιέχει μία προ-γεμισμένη ποσότητα φαρμάκου ώστε να μπορεί αυτόματα κάποιος να χορηγήσει το φάρμακο στον εαυτό του με την ενεργοποίηση αυτής. Μία περαιτέρω άποψη είναι σχετική με μια μέθοδο παροχής ενός θαλάμου που περιέχει φάρμακο (350) μίας συσκευής αυτόματης έγχυσης. Η συσκευή αυτόματης έγχυσης εμπεριέχει ένα περίβλημα (110)' ένα θάλαμο φαρμάκου (350) που έχει ένα πρώτο διαμέρισμα και ένα δεύτερο διαμέρισμα, το πρώτο διαμέρισμα που περιέχει ένα πρώτο τμήμα φαρμάκου (151) και το δεύτερο διαμέρισμα περιέχει ένα δεύτερο τμήμα φαρμάκου (152) που θα αναμιχθεί με το πρώτο τμήμα φαρμάκου (151)' μια δομή σφράγισης (380) ανάμεσα στο πρώτο διαμέρισμα και το δεύτερο διαμέρισμα, η δομή σφράγισης (380) βρίσκεται αρχικά σε μια κατάσταση σφράγισης που διατηρεί το πρώτο διαμέρισμα χωριστά από το δεύτερο διαμέρισμα' μία διάταξη βελόνας (340) που χορηγεί την ποσότητα φαρμάκου από τον θάλαμο φαρμάκου, η διάταξη βελόνας (340) εμπεριέχει μια βελόνα (141) και ένα στήριγμα βελόνας (343), το στήριγμα βελόνας (343) για στερέωση της βελόνας (141) στο θάλαμο φαρμάκου (350), το στήριγμα βελόνας (343) οριοθετεί ένα θάλαμο διάταξης βελόνας (394) που έχει μία εσωτερική επιφάνεια που λεπταίνει ακτινικά προς τα μέσα καθώς εκτείνεται αξονικά προς τα εμπρός προς ένα προς τα πίσω άκρο της βελόνας, το στήριγμα βελόνας (343) σχηματίζει ένα αυλάκι από το θάλαμο φαρμάκου (350) προς την βελόνα' και μια διάταξη ενεργοποίησης (120). Η ενεργοποίηση της διάταξης ενεργοποίησης κάνει (α) η δομή σφράγισης να μετατραπεί από την κατάσταση σφράγισης σε μια κατάσταση ανάμιξης, (β) το πρώτο και δεύτερο τμήμα φαρμάκου (151,152) να αναμιχθούν, και (γ) το αναμεμειγμένο πρώτο και δεύτερο τμήμα φαρμάκου να ωθηθούν διαμέσου της διάταξης βελόνας (340).
Patent CY-1120516-T1 (CY)
Title: Θεραπειες για τον καρκινο
Inventor: GRIFFITH HUGH
IPC: A61P35/00
Filed: 2018-05-18
Abstract: Η εφεύρεση αναφέρεται στο NUC-1031 ([φαινυλο-βενζοξυ-L-αλανινυλο)]-φωσφορική γεμσιταβίνη), ένα ProTide παράγωγο της γεμσιταβίνης, για χρήση στη στόχευση καρκινικών βλαστοκυττάρων. Η στόχευση αυτή των καρκινικών βλαστοκυττάρων μπορεί να αξιοποιηθεί στην πρόληψη ή θεραπεία του καρκίνου. Η εφεύρεση παρέχει επίσης το NUC-1031 για χρήση στη θεραπεία υποτροπιάζοντος ή ανθεκτικού καρκίνου στον άνθρωπο. Χωρίς να επιθυμείται δέσμευση από οποιαδήποτε υπόθεση, πιστεύεται ότι η ικανότητα του NUC-1031 να στοχεύει καρκινικά βλαστικά κύτταρα συμβάλλει στη χρησιμότητα του στη θεραπεία υποτροπιαζόντων ή ανθεκτικών καρκίνων.
Patent CY-1120419-T1 (CY)
Title: Ενισχυση της μεταφορας θεραπευτικων μοριων μεσω του αιματοεγκεφαλικου φραγμου
Inventor: FARRINGTON GRAHAM K
IPC: C07K16/46
Filed: 2018-07-11
Abstract: Η εφεύρεση βασίζεται, τουλάχιστον εν μέρει, στο εύρημα ότι μία διμερική έκδοση ενός αντισώματος το οποίο διαμεταναστεύει μέσω του ΒΒΒ (π.χ., το αντίσωμα δέσμευσης ΤΜΕΜ30Α (CDC-50A), FC5) βρέθηκε ότι ενισχύει σε μεγάλο βαθμό τη μεταφορά μέσω του ΒΒΒ εν συγκρίσει προς το μονοσθενές FC5 VHH. Η εφεύρεση παρέχει, μεταξύ άλλων, μόρια τα οποία αυξάνουν τη μεταφορά των φαρμακολογικά δραστικών παραγόντων μέσω του αιματοεγκεφαλικού φραγμού, μεθόδους για την αύξηση της μεταφοράς μέσω του αιματοεγκεφαλικού φραγμού και μεθόδους αγωγής διαταραχών ή νόσων που έχουν ένα νευρολογικό στοιχείο.