baber/WOPTO huggingface dataset:
Patent UY-24503-A1 (UY)
Title: Derivados de 6-fenilpiridil-2-amina
Inventor: WHITTLE PETER JOHN
IPC: C07D401/12
Filed: 1997-03-26
Abstract: La presente invención se refiere a ciertos derivados de 6-fenil-piridin-2-ilamina que presentan actividad como inhibidores de la óxido nítrico sintasa (NOS), a composiciones farmacéuticas que los contienen y a su uso en el tratamiento de enfermedades inflamatorias, ataque apoplético, dolor agudo y crónico, Alzheimer, Parkinson, artritis reumatoide, ovulación,galucoma, cáncer y prevención de trastornos del sistema nervioso central. Los compuestos de fórmula (I) donde R1 y R2 se seleccionan independientemente, entre alquilo C1-C6, tetrahidronaftaleno y aralquilo, donde el radical arilo de de dicho aralquilo es fenilo o naftilo y el radical alquilo es lineal o ramificado y contiene 1 a 6 átomos ó R1 y R2 forman junto con el nitrógeno al que están unidos, un anillo de piperazina, piperidina o pirrolidina o un anillo azabicíclico que contiene de 6 a 14 miembros en el anillo, de los cuales de 1 a 3 son nitrógenos y el resto son carbonos, siendo ejemplos de dichos anillos azabicíclicos; n y m es 0,1,y 2; R8 y R9 son alquilo, aril-alquilo, donde dicho arilo se selecciona entre fenilo y naftilo,alilo y fenilo. X e y son metilo, metoxi, hidroxi, hidrógeno, etc Ejemplo: 6-(4-(2-(4-fenetil-piperazin-1-il)-etil)-fenil)-piriidin-2-ilamina
Patent UY-26529-A1 (UY)
Title: Composición de gliburida.
Inventor: CAVE GILLIAN
IPC: A61K31/4453
Filed: 2001-01-11
Abstract: La presente invención se refiere a una forma física del fármaco conocido como gliburida, también conocido como glibenclamida, y definido químicamente como 5-cloro-N-2-4- (ciclohexilamino)-carbonil¨amino sulfonil fenil etil -2-metoxibenzamida (Merck Index, Décima Edición, P. 642), así como a formas de dosificación, por ejemplo, tabletas y cápsulas, que incorporan esa forma física de la gliburida.
Patent UY-27300-A1 (UY)
Title: Nuevos derivados de quinolina
Inventor: NEIDHART WERNER
IPC: A61K31/365
Filed: 2002-05-21
Abstract: Los compuestos de la fórmula I así como las sales y ésteres farmacéuticamente aceptables de los mismos, en los que R1, R2, R3, R4, R5 y A tienen los significados definidos en la reivindicación 1, pueden utilizarse en forma de preparados farmacéuticos para el tratamiento o prevención de la artritis, enfermedades cardiovasculares, diabetes, deficiencia renal, trastornos de comida y obesidad.
Patent UY-29192-A1 (UY)
Title: Nuevas formulaciones de comprimidos de liberación modificada para inhibidores de bomba de protón
Inventor: CLEMMENSEN NICLAS
IPC: A61K9/22
Filed: 2005-11-04
Abstract: Forma de dosificación farmacéutica oral sólida que comprende un inhibidor de la bomba de protones (PPI) como único fármaco activo, liberando la PPI en dos impulsos separados, uno inmediato y uno retardado. La PPI se formula con un material central en forma de gránulos que se recubren, entre otras cosas, con una combinación de una capa modificadora de liberación retardada y otra controladora del tiempo de retardo alcanzando juntas propiedades de liberación beneficiosas, procesos para preparar las formas de dosificación y aplicaciones en tratamiento de enfermedades gastrointestinales. Los gránulos se proporcionan, además, con una capa de revestimiento entérica.
Patent UY-29656-A1 (UY)
Title: Grupos de compuestos de amino benzoilos heterociclilos, composiciones farmacéuticas que los contienen, procesos de prepación y aplicaciones
Inventor: DARREN MCKERRECHER
IPC: C07D307/20
Filed: 2006-07-07
Abstract: Compuestos de fórmula (I) en donde R1, HET-1 y HET-2 son como se describe en la memoria, y sus sales y profármacos, son activadores de glucoquinasa (GLK) y por ende son útiles en el tratamiento de, por ejemplo, diabetes tipo 2. También se describen procesos para preparar compuestos de fórmula (I).
Patent UY-31169-A1 (UY)
Title: Compuestos moduladores de sirtuinas
Inventor: PERNI ROBERT B
IPC: A61K31/4353
Filed: 2008-06-20
Abstract: Se revelan novedosos compuestos moduladores de sirtuinas, además de métodos para su uso. Los compuestos moduladores de sirtuinas pueden utilizarse para el aumento del ciclo de vida de una célula, y el tratamiento y/o prevención de una amplia variedad de enfermedades y trastornos que incluyen, por ejemplo, enfermedades o trastornos relacionados con el envejecimiento o el estrés, diabetes, obesidad, enfermedades neurodegenerativas, enfermedad cardiovascular, trastornos relacionados con la coagulación de la sangre, inflamación, cáncer y/o crisis vasomotora, así como enfermedades o trastornos que se aliviarían con el aumento de la actividad mitocóndrica. También se revelan composiciones que comprenden un compuesto modulador de las sirtuinas en combinación con otro agente terapéutico.
Patent UY-31581-A1 (UY)
Title: Derivado 15, 16-metilen-17-(1' - propenil)-17-3' -oxidoestra-4-en-3-ona, su uso y medicamento que lo contiene
Inventor: MENGES FREDERIK
IPC: A61K31/343
Filed: 2008-12-26
Abstract: Derivados de 15,16-metilen-17-(1`-propenil) -17-3` -oxidestra-4-en -3 -ona que tienen la formula química general I , donde z se selecciona del grupo que comprende oxígeno, dos átomos de hidrogeno , NOR   y NNHSO2R   donde R   es hidrogeno, C1-C10-alquilo o C7-C20-aralquilo, R4 se selecciona del grupo que comprende hidrogeno y halogeno.
Patent CH-710592-A1 (CH)
Title: Waschmaschine mit Unwuchtkompensation.
Inventor: GUIDO SCHELLENBERG
IPC: D06F34/16
Filed: 2015-01-06
Abstract: Um eine Unwucht in der Beladung einer Waschmaschine auszugleichen, sind erfindungsgemäss an der Trommel (2) der Waschmaschine mindestens sechs Wassertanks (10a, 10b) auf unterschiedlichen axialen Positionen vorgesehen. Die Wassertanks (10a, 10b) sind zueinander versetzt und es sind Verbindungsrohre (17) vorgesehen, welche durch die Rippen der Trommel (2) führen. Diese Ausgestaltung erlaubt es, die Unwucht der Trommel (2) mit einfachen Mitteln gut zu kompensieren.
Patent ES-149804-A1 (ES)
Title: PERFECCIONAMIENTOS EN LAS MáQUINAS DE ESTADiSTICA
IPC: G06K19/06
Filed: 1940-06-27
Abstract: Perfeccionamientos en las máquinas de estadística de la clase descritateniendo medios para el avance sucesivo de elementos de mando llevando datos en colores istintoscontenidos en los varios elementos de mando y medios para la exploración de dichos datoscaracterizados por estar dotada la máquina de medios detectores de los cambios de color de los datos en las secciones de la película que van sucediéndosepara dirigir las operaciones de avance de la película.
Patent ES-180676-A1 (ES)
Title: MEJORAS EN CIRCUITO CON TUBOS TERMOIoNICOS PROVISTOS DE CONTROL DE GANANCIA
Filed: 1947-11-27
Abstract: Mejoras en circuitos con tubos termoiónicos, provistos de control de ganancia, las cuales se aprovechan en aparatos dotados de tubos termoiónicos provistos de electrodos aceleradores para producir una corriente primaria de electrones y para controlar la intensidad de la corriente de electrones que pasa por el electrodo acelerador: dispone, además, de medios tales como una pantalla de desviación a bajo potencial, un electrodo acelerador más y un electrodo de emisión secundaria para dirigir el haz desde dicho electrodo acelerador por una trayectoria de forma curva a un electrodo de emisión secundaria para producir un segundo haz dirigido a un electrodo colector análogo al segundo electrodo acelerador, caracterizado pr la provisión de medios para variar el potencial de la pantalla de desviación con respecto a aquel de dichos otros electrodos para controlar la corriente de electrones primaria y de aquí la amplitud del haz electrónico secundario.
Patent ES-183147-A1 (ES)
Title: UN APARATO CONSISTENTE EN UN AVISADOR AUTOMáTICO DE ALARMA
Filed: 1948-04-05
Abstract: Aparato avisador o de alarma automático, que se caracteriza en su esencialidad, por la producción de una señal acústica o lumínica consecutiva a la conexión de un dispositivo eléctrico, consistente en una caja sin fondo conteniendo como base inferior, una masa de material susceptible de fusión a temperatura prevista, la cual por su parte alta y adherida a ella tiene una platina aislante, la cual, presenta solidaria a ella una varilla que perforando el tabique superior de la caja, atornilla en su extremo una segunda platina más pequeña en cuya cara interior, se sitúan dos topes de conexión , los que a su vez, tiene perfecta correlación con sus oponentes, situados en la parte externa de la pared de la caja.
Patent ES-191871-A1 (ES)
Title: UN PROCEDIMIENTO DE FABRICACIoN DE UN EXTINTOR SoLIDO DE INCENDIOS
Filed: 1950-02-28
Abstract: Procedimiento o fabricación de un extintor sólido de incendios, caracterizado porque en un molturador se deposita la cantidad necesaria de bórax, bromuro, potásico y bicarbonato sódico donde aisladamente son pulverizados hasta obtener un polvo impalpable, conseguido lo cual se deposita en un molturador un 25% de bórax, 10% de bromuro potásico y un 65% de bicarbonato sódico, haciéndose una perfecta mezcla de este producto, quedando así en condiciones de ser depositado en los envases para su venta al público.
Patent ES-192469-A1 (ES)
Title: UN PROCEDIMIENTO DE PREPARACIoN DE AMINOCETONAS Y DE SUS DERIVADOS
Filed: 1950-04-10
Abstract: Un procedimiento de preparación de amino-catones de sus derivados y de sus sales caracterizado porque se hace reaccionar con intervención de cloruro de aluminio como agente de condensación y eventualmente en presencia de ácido clorhídrico gaseoso en un disolvente de polaridad pronunciada que no participa en sí mismo en la reacción con un compuesto que responde a una de las fórmulas designando R y grupos alcohílicos o aralcohílicos con un compuesto que responde a la fórmula en la cual y designen hidrógeno o grupos alcohílicos o aralcohílicos o constituyen un ciclo con el átomo de nitrógeno o aún reaccionar con una sal de este amino-nitrilo y de un ácido mineral fuerte y porque se trata la mezcla de reacción con agua y luego se eliminan parcial o totalmente los grupos alcohílicos o aralcohílicos de la cetona formada y en su caso se reduce la cetona en un alcohol secundario.
Patent ES-193066-A1 (ES)
Title: UNA LáMPARA DE DESCARGA DE BAJA PRESIoN
IPC: H01J61/20
Filed: 1950-05-20
Abstract: Una lámpara de descarga que comprende una ampolla vítra alargada y un electrodo en cada porción extrema de dicha ampolla caracterizada porque la ampolla contiene una mezcla de criptón y neón o criptón y argón con adición de vapor de mercurio siendo la proporción del criptón de al menos 45% y siendo tal la del resto que la generación de radiación ultra-violeta está aproximadamente en el máximo.
Patent ES-244415-A1 (ES)
Title: Method of producing a means for influencing plant growth
IPC: A01N37/44
Filed: 1958-09-29
Abstract: Plant growth regulating compositions comprise a solid or liquid carrier and one or more benzonitrile derivatives of general formula <FORM:0906118/I/1> wherein R represents a hydrogen atom or a CH3-, C2H5-, CH3CO- n -CH2COOH group, X represents an oxygen or sulphur atom and Y represents a halogen atom or a C1-4 alkyl a alkoxy group or an amino or acetylamino group. They may be in such forms as water miscible oils, wettable powders and dusts. If the carrier is a solvent for the active constituent it also includes a surface active agent. Hydrocarbon oils, kieselguhr, kaolin, chalk, pipeclay, magnesium, marlstone, dolomite and attapulgite may also be added. Specification 358,279 is referred to.ALSO:Plant growth regulating compositions comprise a solid or liquid carrier and one or more benzonitrile derivatives of general formula <FORM:0906118/VI/1> wherein R represents a hydrogen atom or a CH3-, C2H5-, CH3CO- or HOOC.CH2-group, X represents an oxygen or sulphur atom and Y represents a halogen atom or a C1-4 alkyl or alkoxy group or an amino or acetylamino group. They may be in such forms as water-miscible oils, wettable powders and dusts. If the carrier is a solvent for the active constituent it also includes a surface-active agent. Specification 358,279 is referred to.
Patent ES-259055-A1 (ES)
Title: Method of lowering the iron content of chromite ores or concentrates without appreciable lowering of the contained cr2o3
IPC: C22B34/32
Filed: 1960-06-18
Abstract: The Fe content is partially extracted from chromite ore by roasting the ore in air at 700-750 DEG C., reducing the Fe2O3 so formed to Fe3O4 and Fe by heating the ore to 1200-1370 DEG C. in the presence of a gaseous reducing agent and leaching the soluble iron. The gaseous reducing agent is produced in situ by mixing the oxidised ore with coal. The reduced ore may be leached with sulphurous acid or weak sulphuric acid. The hot exhaust gases from the reducing stage may be used as the source of heat for the roasting stage. Specification 951,087 is referred to.
Patent ES-261047-A1 (ES)
Title: Process for the manufacture of catalysts for the production of monomeric vinyl estersin the gaseous phase
IPC: B01J21/18
Filed: 1960-09-15
Abstract: Catalysts, for the gas phase reaction of organic acids with acetylene to give vinyl esters, are manufactured by causing a solution of Zn or Cd acetate to move through a static mass of active carbon particles at room temperature, the solution having a volume greater than the absorptivity of the mass and containing more acetate than is to be taken up by the mass the unabsorbed solution and the mass containing absorbed solution are separated when the concentration has reached cx - ba/c - be where a is the desired Zn or Cd content of the catalyst (g./kg.), b is the weight in kg. of the untreated mass, c is the volume of the acetate solution (l.), e is the absorptivity of the active carbon (l./kg.), and x is the initial concentration of Zn or Cd in the solution (g./l.).
Patent ES-298614-A1 (ES)
Title: Improvements in or relating to a heat exchange panel
IPC: F24H9/12
Filed: 1964-04-13
Abstract: A heat radiator panel comprises the assembly of two steel sheets A and B which are blanked and pressed out to form therebetween two horizontal longitudinal manifolds a and b interconnected by a series of vertical passageways 4, the manifold a being connected to a supply pipe of a heating circuit and the manifold b to a return pipe. As shown the manifolds are formed in the back panel B which is also formed with vertical grooves 10, separated by flat portions 17, and with inlet and outlet apertures to which screw-threaded bushings 1 and 2 are welded. The passageways 4 in panel A are separated by plane portions 5 which are spot welded to the portions 17, Fig. 2 (not shown). The mating edges of the sheets are seam welded together and the corners 18 cropped round. Mounting tabs 19 are welded to two successive ribs formed by the grooves 10. Since the grooves 10 are too deep to permit their formation in one press operation without splitting or bursting of the metal they may be formed in successive press operations by three punches of successively increasing depth.
Patent ES-301941-A1 (ES)
Title: Cleaning device for framemounted net filters
IPC: B01D46/52
Filed: 1964-07-10
Abstract: A frame-mounted gas filter I is cleaned by a suction head 6, having a suction slot 7 coacting with the filter, the head 6 reciprocating along the length of the filter and communicating with a slot 4 in suction box 3, in which slot 4 head 6 is mounted, box 3 being connected to a suction fan by duct 5. The slot 4 is covered by a flexible steel strip 15 which is pressed aside by a cam 16 on head 6 to allow communication between opening 8 to slot 7 and the inside of box 3. Head 6 is moved on an endless chain 9, by a reversible motor driving shaft 14, chain 9 carrying a plate 17 which closes duct 5 in one position of head 6, enabling several cleaning devices to operate sequentially using a common fan.
Patent ES-303706-A1 (ES)
Title: Apparatus for mounting an injection mold for angular movement
IPC: B29C45/10
Filed: 1964-09-02
Abstract: In an injection moulding machine the mould halves are held between plates 29 and 35 movable along the length of a support unit 26 and the unit 26 is rotatable about the longitudinal axis of injection unit 2. Plate 29 is attached to a block 27 which slides on bars 41 and plate 35 is movable along rods 28 by means of an hydraulically operated piston and toggle mechanism, Fig. 3 (not shown), attached to a second block 31. This block may also be moved along rods 28 so that the mould halves when closed may be moved from a postion where the injection nozzle (15), Fig. 2 (not shown), is in line with the mould parting line, to a position where injection takes place along the axis of unit 26, see Fig. 4 (not reproduced). The rotation of unit 26 is achieved by the co-operation of rollers mounted on plate 23 with an annular groove in fixed plate 5, a lock (26a), Fig. 4 (not shown), being provided to hold unit 26 in any desired position. The injection unit 2 comprises a feed screw (9), Fig. 2 (not shown), movable axially by reciprocation of a piston (14) within a cylinder (6). The injection unit itself is also movable axially either manually or hydraulically, to facilitate access to the injection nozzle, and is locked in position by co-operation of couplings (18) and (21). Two injection units may be arranged coaxially to feed the mould with different materials or material of differing colours. Metallic inserts may be incorporated in the mouldings.
Patent ES-303708-A1 (ES)
Title: Improvements in or relating to building components
IPC: E04B1/68
Filed: 1964-09-02
Abstract: A flat wall comprises horizontal rails, Fig. 3, (not shown), supporting overlapping concrete or other panels having interfitting rebates 13, 14 at top and bottom enclosing a horizontal rail so that the outer panel faces lie in a common plane, the two edge faces of each panel having angled metal strips 18, 19 embedded along a line oblique to said plane to form projecting lips between panels which nest at horizontal joins, Fig. 4, (not shown). Vertical weld lines (21) unite the abutting lips to form a weatherproof joint, surplus metal being cut off. The vertical joints may be concealed by cover panels. In a modification the panels are arranged to provide horizontal welded joint lines.
Patent ES-336114-A1 (ES)
Title: Process for the Production of Epsilon-Caprolactone.
IPC: C07D313/04
Filed: 1967-01-26
Abstract: Epsilon-caprolactone is prepared by heating esters or self-polyesters of epsilon-hydroxycaproic acid between approximately 150 and 350 C. in the presence of a basic compound as catalyst. Reduced pressure is preferred and the reaction products may be distilled as they are formed, or the alkanol first in the case of an alkyl ester. The basic compound may be a hydroxide, oxide, carbonate, cyanide, alcoholate, acetate or propionate of an alkali or alkaline earth metal, Mg, Zn, Cd, Al, Ti, Pb, Sn, or Sb, or a basic salt such as a Cu or Ag basic carbonate or acetate.
Patent ES-336470-A1 (ES)
Title: Methylalkanoyloxymethyl ketals of prednisolone derivatives
IPC: C07J71/00
Filed: 1967-01-24
Abstract: The invention comprises compounds of formula <FORM:1120337/C2/1> wherein R is an alkyl group having 3-5 carbon atoms and X is a hydrogen or fluorine atom, and their preparation by reaction of the corresponding 16a ,17a -diol with the appropriate alkanoyloxy-acetone. Pharmaceutical compositions.-The compounds of the invention have anti-inflammatory activity and may be used in ointments, creams, gels, tablets, and spirit solutions.
Patent ES-339732-A1 (ES)
Title: Conglutination of Enzymes and Detergent Compositions
IPC: C11D3/39
Filed: 1967-04-25
Abstract: A process for making free-flowing enzymecontaining detergent granules comprises: (i) rendering the surface of base detergent granules which range in particle size from 0.075 mm. to 3.3 mm. and pass through a Tyler Standard 6 mesh screen and are retained on a 200 mesh screen and have an average bulk density of from 0.2 to 0.8 gm/cc, glutinous with from 3 to 90% by weight of said base detergent granules of a nonionic surface active agent which liquefies between 110 F. and 200 F. is solid at temperatures below 110 F. and is soluble in aqueous solutions and (ii) conglutinating with the glutinous surfaces of said base detergent granules, to form finished granules, from 0.001 to 40% by weight of the finished granules of active enzymes, said enzymes being in powder form and being substantially pure active enzymes or being included in enzyme compositions, said enzymes being active in the pH range 4 to 12 and the temperature range 50 to 185 F. Enzymes include hydrases, oxidoreductases, transferases, desmolases and isomerases and preferred enzymes are the hydrolases, e.g. proteases, esterases, carbohydrases and nucleases. The base granules can consist solely of builder salts or they can contain a combination of builder salts and organic detergent compounds the builder salts are preferably anhydrous or partially hydrated. The usual detergent additives which enhance attractiveness, and effectiveness may be included in the base granules.
Patent ES-342391-A1 (ES)
Title: Novel 1-(2-Aminophenyl)-1,2,3,4-tetrahydroisoquinolines
IPC: A61K31/00
Filed: 1967-06-27
Abstract: Novel compounds of formula (wherein R is H, C 1-3 alkyl, aralkyl, or an aliphatic, aromatic or araliphatic acyl group, R 1 is C 1-5 alkyl, R 2 is C 1-5 alkyl or benzyl, or R 1 and R 2 with the intervening carbon atom form a cycloaliphatic ring, and R 3 is H or methyl) and their physiologically compatible acid addition salts with inorganic or organic acids, are prepared (A) by reducing the corresponding 1- (2 - aminophenyl) - 3,4 - dihydroisoquinolines, any acyl group (R) being retained, reduced or cleaved during this reaction depending upon the reducing agent or (B) by reducing the corresponding 1 - (2 - nitrophenyl) - 3,4 - dihydroisoquinolines either in a single step or in two steps via a 1-(2-nitrophenyl)-1,2,3,4- tetrahydroisoquinoline or (C) by condensing an appropriate 2-phenyl-ethylamine with an appropriate o-aminobenzaldehyde either in a single step or in two steps via a Schiffs base or (D) by condensing an appropriate 2-phenylethylamine with o-nitrobenzaldehyde, reducing the nitro group to amino in the resulting Schiffs base which is then cyclized. Processes A-D yield bases of Formula I which may be salified when required. Product interconversions described are (a) alkylation, aralkylation and acylation of compounds wherein R is H to obtain compounds wherein R is other than H, and (b) reduction of compounds wherein R is acyl to obtain compounds wherein R is alkyl or aralkyl. 1 - 2 - (Aminophenyl) - 3,4 dihydroisoquinolines, with substituents R, R 1 , R 2 and R 3 as in Formula I are prepared by cyclizing oaminobenzonitrile with an appropriate carbinol, followed when required by conversion of R as described at (a) and (b) above. 1 - (2 - Nitrophenyl) - 3,4 - dihydroisoquinolines with substitutents R 1 -R 3 as in Formula I are prepared by cyclizing o-nitrobenzonitrile with an appropriate carbinol. Compounds of Formula I and their compatible addition salts with inorganic and organic acids are stated to possess antiphlogistic and anti-pyretic activity, and may be made up with carriers or excipients into pharmaceutical compositions which may be administed by oral, parenteral or rectal routes.
Patent ES-343995-A1 (ES)
Title: 2-beta-hydroxy ethylamino-4-5-diphenyl-oxazole
IPC: C07D263/48
Filed: 1967-08-10
Abstract: i Pharmaceutical compositions having antiinflammatory and anti-phlogistic activity comprise, as active ingredient, a 2-substituted-4, 5-diphenyl-oxazole of the general formula wherein R is (a) a monoalkyl-substituted amino group, (b) a dialkyl-substituted amino group, (c) a hydroxy-alkyl-substituted amino group, (d) an alkyl- and hydroxyalkyl-substituted amino group, (e) a bis-hydroxy-alkyl-substituted amino group, (f) an N,N-dialkyl-aminoalkyl-substituted amino group or (g) a 5- or 6-membered. heterocyclic radical having a ring nitrogen atom linked to the 2-carbon atom of the oxazole ring, together with a pharmaceutical carrier therefor. The compositions may be administered orally as tablets or sugar-coated pills.