baber/WOPTO huggingface dataset:
Patent CA-2321881-A1 (CA)
Title: Non-imidazole alkylamines as histamine h3-receptor ligands and their therapeutic applications
Inventor: STARK HOLGER
IPC: C07C217/16
Filed: 1999-07-29
Abstract: Use of a compound of formula (A), wherein: W is a residue which imparts antagonistic and/or agonistic activity at histamine H3-receptors when attached to an imidazole ring in 4(5) position; R1 and R2 may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H3-receptors of histamine.
Patent CA-2327445-A1 (CA)
Title: Recombinant potyvirus construct and use thereof
Inventor: GAL-ON AMIT
IPC: A01N63/02
Filed: 1999-03-30
Abstract: The present invention relates to a recombinant potyvirus infectious nucleic acid, preferably cDNA or RNA, construct useful for plant cross protection, comprising a full length clone characterized in that its HC-Pro gene conserved FRNK box sequence contains a substitution, preferably a substitution of Arg.  Preferably, the construct further contains a substitution which effectively abolishes aphid transmissibility. The present invention further relates to a method for the production of a mild strain of potyvirus utilizing the above mentioned construct and to a method for protecting plants from viral infection and for transient expression of foreign nucleic acid (genes) in plants, using said construct. Preferably, the present invention relates to a method for cross protection of curcurbits against ZYMV infection. The present invention also relates to a method for providing protection against viral infection in plants comprising inoculating plants, by mechanical inoculation or by bombardment, with the recombinant potyvirus infectious construct.
Patent CA-2329136-A1 (CA)
Inventor: RYBICKI EDWARD P
IPC: A61P35/00
Filed: 1999-05-27
Abstract: The present invention is directed to a method of expressing the papillomavirus capsid protein coding sequence in a cell using an expression system under conditions facilitating expression of the protein in the cell, In another aspect of the invention, it has been discovered that virus-like particles) (VLPs), fragment(s), capsomer(s) or portions) thereof are formed from the papillomavirus capsid protein. It was further discovered that the virus-like particle(s) comprises antigenic characteristics similar to those of native infectious papillomavirus particles. In one embodiment of the invention, there is provided a method of expressing the L1 major capsid protein of human papillomavirus type-6 (HPV-6) and type-11 (HPV-11 ) in Sf-9 insect cells using the baculovirus expression system, and the production of type 6 (HPV-6), type-11 (HPV-11), type-16 (HPV-16) and type-18 (HPV-18) virus-like particles.  In yet another embodiment, the invention provides a method of vaccinating a mammal for papillomavirus by administering papillomavirus virus-like particles orally to a mammal in an amount sufficient to induce an immune response to the papillomavirus.
Patent CA-2332624-A1 (CA)
Inventor: SCHALLER MARTIN K JR
IPC: A23G4/06
Filed: 1999-04-22
Abstract: A chewing gum composition for instant and extended release breath freshening  has a gum base, at least one wetting agent, at least one immediate release flavor ingredient, and at least one encapsulation. The encapsulations includ e flavor encapsulations, metallic ion encapsulations, and organic substance encapsulations.
Patent CA-2333089-A1 (CA)
Inventor: KHETANI VIKRAM
IPC: C07D213/40
Filed: 1998-05-26
Abstract: Processes and intermediates for preparing 2-substituted piperidines such as 2-substituted d-threo piperidines are provided. In preferred embodiments, the processes of the invention comprise the steps of reacting a 2-substituted pyridine with hydrogen in the presence of a catalyst in an alkanoic acid, and adding an alkyl alkanoate to the resulting mixture of threo and erythro 2-piperidine stereoisomers to precipitate alkanoate salts of the erythro stereoisomers preferentially with respect to alkanoate salts of the threo stereoisomers. The erythro salts thenare reacted with aqueous base to form the corresponding mixture of erythro amide free bases, which are reacted with a suitable organic acid resolving agent in an alkyl alcohol solvent to form acid salts of the l-erythro stereoisomers preferentially with respect to the d-erythro stereoisomers. The l-erythro acid salts are then reacted with aqueous base to form the l-erythro piperidine amide free base which, in turn, is epimerized to produce the desired d-threo product by treating it in an organic solvent with an alkali metal alkoxide.
Patent CA-2333182-A1 (CA)
Title: Method for remote connection of machines and corresponding electronic analog apparatus
Inventor: TAILLENS JEAN-FRANCOIS
IPC: H04W84/20
Filed: 1999-05-17
Abstract: The method for remote connection consists in identifying poles of interest common to several persons according to a technique which detects the areas of activity and the poles of interest and broadcasts them. The itinerant apparatus (1) comprises a data processing module (2) connected directly or not by a bus (3) to a display module (4), data selecting means (5) sound generating means (6) and several interface means (10, 11, 12) capable of connecting or adapting the device to other remote communication means. The apparatus (1) is capable of broadcasting (9) and picking up (8) codes selected in a nomenclature common to all the machines of the switchboard to encounter another apparatus containing at least a similar code. The machines (16a, 16b, 16c, 19d, 16e, 16f) exchange together their respective selections in interactive mode which passes through a transmission space (17, 18) systematically produced when at least two machines meet within operational distance. A sound signal and/or the display of parameters concerning the desired activities is activated if the selected codes in the machines concerned are matching. The invention is useful in particular for identifying, aims, poles of interest and/or areas of activity common and/or complementary to several persons located in the proximity of one another.
Patent CA-2333466-A1 (CA)
Title: Gbs toxin receptor
Inventor: HELLERQVIST CARL G
IPC: A61P17/02
Filed: 1999-07-22
Abstract: A novel GBS toxin receptor, and methods for its preparation and use are provided. GBS toxin receptor polynucleotides and polypeptides are provided as well as detection, screening, and therapeutic methods and pharmaceutical compositions involving such polynucleotides and polypeptides.
Patent CA-2333690-A1 (CA)
Inventor: NUNEZ GEORGE A
IPC: A61B17/32
Filed: 1999-05-17
Abstract: A full-thickness resection system with a flexible endoscope (8a) and a stapling mechanism (2), wherein the endoscope (8a) is slidably received through at least a portion of the stapling mechanism (2). The stapling mechanism (2) comprises an anvil (10) and a stapling head mounted to the anvil (10) and moveable with respect to the anvil (10) to form a gap between a tissue receiving position and a stapling position. A position adjusting mechanism (102) is provided for moving the anvil (10) and stapling head between the tissue receiving and stapling positions and a staple firing mechanism (104) sequentially fires a plurality of staples from the stapling head across the gap against the anvil (10) and through any tissue received in the gap and a knife (202) cuts a portion of the tissue received in the gap. A control unit (6), which remains outside the body, is coupled to the stapling mechanism (2) for controlling the operation of the position adjusting mechanism (102) and the staple firing mechanism (104).
Patent CA-2334908-A1 (CA)
Title: Film thermoplastique multicouches et procede de decoupe de signes utilisant celui-ci
Inventor: BAID KUSHALKUMAR M
IPC: B29C48/08
Filed: 1999-06-11
Abstract: L'invention a trait à un film thermoplastique multicouches comportant: une couche (16) centrale thermoplastique présentant une première face et une deuxième face, la couche centrale comportant: une polyoléfine dont la densité se situe entre environ 0,89 et environ 0,97 grammes par centimètre cube; une deuxième matière polymère sélectionnée dans le groupe constitué par des copolymères d'éthylène-acide acrylique, des copolymères d'éthylène-acide méthacrylique, des ionomères dérivés de sodium, de lithium ou de zinc et d'un copolymère d'éthylène/acide méthacrylique, et une combinaison de ceux-ci, la deuxième matière polymère thermoplastique étant présente selon une concentration d'environ 2 % à environ 25 % en poids par rapport au poids de la couche centrale; et un photostabilisant selon une concentration d'environ 1000 à environ 10000 ppm par rapport au poids de la couche centrale; une première couche (18) de peau thermoplastique transparente résistant à l'abrasion et aux éraflures recouvrant la première face de la couche centrale, la première couche de peau comportant un photostabilisant selon une concentration d'environ 2000 à environ 20000 ppm par rapport au poids de la première couche de peau; et une deuxième couche (20) de peau thermoplastique transparente recouvrant la deuxième face de la couche centrale, la deuxième couche de peau comportant un photostabilisant selon une concentration d'environ 1000 à environ 10000 ppm par rapport au poids de la deuxième couche de peau. La composition de la couche centrale est différente de celle des couches de peau. La couche centrale et les couches de peau sont caractérisées par une absence de PVC. L'invention a également trait à un procédé de découpe de signes utilisant le film thermoplastique multicouches susmentionné.
Patent CA-2335513-A1 (CA)
Inventor: MACPHERSON DAVID TIMOTHY
IPC: C07C259/06
Filed: 1999-06-22
Abstract: Compounds of formula (I) wherein: R is methyl substituted by one to three groups selected from alkyl, aryl, alkenyl, and alkynyl; n is 0 or 1; R1 is arylmethyl or heterocyclylmethyl; R2 is alkyl, alkenyl, cycloalkyl or cycloalkenyl; and R3 is hydrogen, alkyl, alkenyl, alkynyl or aryl; are useful in the treatment of disorders mediated by s-CD23.
Patent CA-2335659-A1 (CA)
Title: Cleaning arrangement of a sieve
Inventor: FRERICH JOSEF
IPC: F01P11/06
Filed: 2001-02-09
Abstract: An arrangement for cooling the engine of a harvesting vehicle includes a circular sieve or screen mounted for rotation about a fore-and-aft axis and through which air is drawn by a fan which discharges the air through a cooling device. A cleaner in the form of a brush includes a cylindrical bristle arrangement mounted for rotating about an axis arranged parallel to an inlet side of the sieve with the bristles projecting through sieve openings. Located on the outlet side of the sieve is a suction device that acts to carry away contaminants poked through the sieve by the bristles of the brush. A further embodiment of the invention includes a second suction device mounted adjacent the inlet side of the sieve in trailing relationship to the brush arrangement so as to be able to carry away contaminants loosened by the brush arrangement but still clinging to the inlet side of the sieve.
Patent CA-2336893-A1 (CA)
Title: Means and methods for enhancing the content of sulfur compounds in plants
Inventor: HARMS KARSTEN
IPC: A01H5/00
Filed: 1999-07-07
Abstract: Described are recombinant DNA molecules comprising a nucleic acid molecule encoding a protein having serine acetyltransferase (SAT) activity and optionally a nucleic acid molecule encoding a protein having cysteine-.gamma .- synthase (C.gamma.S) activity; wherein said nucleic acid molecule(s) are operably linked to regulatory elements allowing the expression of the nuclei c acid molecule(s) in plant cells. Also provided are vectors comprising said recombinant DNA molecules as well as plant cells, plant tissues and plants transformed therewith. In addition, the use of the aforementioned recombinan t DNA molecules and vectors in plant cell and tissue culture, plant breeding and/or agriculture is described as well as the use of the aforementioned plants, plant tissue and plant cells for the production of food, feed and additives therefor.
Patent CA-2337390-A1 (CA)
Title: Thermoplastic moulding materials based on special highly effective grafted polymer components
Inventor: EICHENAUER HERBERT
IPC: C08F279/04
Filed: 1999-07-05
Abstract: The invention provides thermoplastic moulding compositions of the ABS type containing specific highly effective graft polymer components which are obtained by emulsion polymerization using specific initiator systems and observing defined reaction conditions.
Patent CA-2339102-A1 (CA)
Inventor: CHARLES MARIE-HELENE
IPC: C07K5/06
Filed: 1999-07-27
Abstract: The invention concerns a saturated or unsaturated abietane derivative of general formula (I) wherein: Z is selected among -COOR?5¿, -CONR?1¿R?2¿, -COONR?3¿R?4¿, -COR?6¿, -CON, -COOR?5¿, -CHOHR?7¿, -SR?8¿, -OR?8¿, -CN, -CNO, -CNS, -NCO, -NCS, -R?1¿R?2¿CR?9¿; wherein R?1¿, R?2¿, R?3¿ and R?4¿ represent a hydrogen atom, a C¿1?-C¿10? alkyl, a C¿6?-C¿20? aryl optionally substituted; a C¿7?-C¿10? alkene; a C¿1?-C¿10? alkyne; an aminoacyl or peptidyl optionally substituted; or R?1¿ and R?2¿ or R?3¿ and R?4¿ together can form a cycle or a heterocycle; R?5¿ represents a hydrogen, a C¿1?-C¿10? alkyl, a C¿1?-C¿10? alkene, a C¿1?-C¿10? alkyne; an aryl, optionally substituted into C¿6?-C¿20?; R?6¿ represents a hydrogen, a halogen, a C¿1?-C¿10? alkyl, a C¿1?-C¿10? alkene, a C¿1?-C¿10? alkyne, an aryl optionally substituted into C¿6?-C¿20?; R?7¿ represents a hydrogen, a C¿1?-C¿10? alkyl, a C¿1?-C¿10? alkene, a C¿1?-C¿10? alkyne; R?8¿ represents a hydrogen, a C¿1?-C¿10? alkyl, a C¿1?-C¿10? alkene, a C¿1?-C¿10? alkyne; and R?9¿ is selected among -CN, -CNO, -CNS, -NCO, and -NCS. The invention also concerns a derived conjugate and the use of said derivative and said conjugate in a diagnostic composition, a reagent and a device.
Patent CA-2344953-A1 (CA)
Title: Improved hydrocracking process
Inventor: HOEHN RICHARD K
IPC: C10G49/22
Filed: 2001-04-25
Abstract: A catalytic hydrocracking process wherein a hydrocarbonaceous feedstock and a liquid recycle stream is contacted with hydrogen in a hydrocracking reaction zone at elevated temperature and pressure to obtain conversion to lower boiling hydrocarbons. A liquid hydrocarbonaceous stream produced from the effluent of the hydrocracking reaction zone is fractionated to produce at least one liquid hydrocarbonaceous product stream and a liquid hydrocarbonaceous stream containing hydrocarbons boiling at a temperature in the boiling range of the feedstock and heavy polynuclear aromatic compounds. At least a portion of the liquid hydrocarbonaceous stream containing heavy polynuclear aromatic compounds is introduced into a zone of the divided-wall fractionation zone to produce a stream rich in polynuclear aromatic compounds. At least another portion of the liquid hydrocarbonaceous stream containing hydrocarbons boiling at a temperature in the boiling range of the feedstock is recycled to the hydrocracking reaction zone.
Patent CA-2345646-A1 (CA)
Inventor: MELVIN DAVID B
IPC: A61M1/10
Filed: 1999-09-30
Abstract: A geometric reconfiguration assembly for the natural heart having a collar configured for surrounding the natural heart. The collar can include a plurality of supports configured for positioning on the epicardial surface of the heart. Supports can be joined with connectors that can permit or provide slight deformation of the assembly. An external shell or skin portion can be provided around the supports and/or connectors.
Patent CA-2348397-A1 (CA)
Title: Method of forming diamond film and film-forming apparatus
Inventor: MEGURO KIICHI
IPC: C30B25/02
Filed: 2001-06-05
Abstract: A method and an apparatus for forming a diamond film from microwave plasma by controlling a manufacturing condition based on spectroscopic measurement of plasma emission to obtain a large area of a high-quality diamond film. In the method of forming a diamond film, a gas mixture of hydrocarbon gas and hydrogen gas is introduced into a reactor, where the gas mixture is excited by microwave which is also introduced into the reactor to generate plasma, and the light emitted from the plasma is spectroscopically measured. Furthermore, a formation condition of the diamond film is controlled such that the spectrum of a carbon molecule (C2) falls within a predetermined range of requirement.
Patent CA-2348554-A1 (CA)
Title: A method for predicting the directional tendency of a drilling assembly in real-time
Inventor: LESSO WILLIAM
IPC: E21B47/022
Filed: 2001-05-25
Abstract: The invention uses the continuous inclination, direction and tool-face information supplied from either an MWD tool and/or a rotary steerable drilling system, and/or other downhole equipment, e.g., the at-bit inclination measurement (AIM), to give a prediction of the tendency of a rotary, steerable, or rotary steerable system. These measurements are used with a finite element mathematical model of the drilling process to continually calibrate in real-time the drilling parameters that are not obtainable from measurements, and to refine the subsequent tendency prediction in real-time.  The continuous data will be used in conjunction with the accepted survey measurements (which occur less frequently than the continuous inclination and direction measurements) so that the optimum slide and rotation ratio between well sections can be selected, and drilling targets can be more accurately hit.
Patent CA-2350176-A1 (CA)
Inventor: GILE DENNIS
IPC: E04D13/158
Filed: 2001-06-12
Abstract: A cornice device for building structures including a crown member and a connector member. The crown member has a first end configured to attach to the roof portion of the building structure and a second end. The crown member may include an optional fascia board and an optional roof nailer member attached to the fascia board. The connector member comprises a first leg configured to cooperate with the second end of the crown member. The second leg of the connector member is configured to couple to the outer wall of the building structure. The crown member and the connector member are configured to flex during installation to accommodate for various framing variances. The cornice device also includes means for discharging water from the cornice device which is spaced apart the outer wall of the building structure so as to keep the water discharged from and off the cornice device from damaging the outer wall. In one embodiment, the means for discharging water from the cornice device comprises a water trough and a plurality of apertures formed in the connector member, the crown member, or both. The apertures are configured to allow water to pass therethrough and also act as a means for ventilating a building structure. The apertures are substantially hidden from view. The means for discharging water from the cornice device may also comprise a drip lip which is configured to prevent water discharged off the cornice device from staining, discoloring, or damaging the outer wall of the structure. In one embodiment, the drip lip is formed by the second end of the crown member and the first leg of the connector member.
Patent CA-2351596-A1 (CA)
Inventor: BENECKE ARNOLD GEORGE
IPC: C11D3/50
Filed: 1999-11-22
Abstract: A gear pump and reservoir device for a fluid sprayer comprises a pump housing (12) having a recessed portion for receiving and sealing thereto a fluid reservoir and a cavity for locating a drive motor (56) and gears (62, 64) therein. The recessed portion has a rigid conical projection (18) centered therein which has an orifice (20) extending into a pump inlet (22). The gear pump further includes a fluid container (36) mounted above the recessed portion of the pump housing to form a fluid reservoir. The fluid reservoir has a discharge valve (52) that is opened by engagement with the conical projection within the recessed portion to provide fluid communication to the pump inlet. A static head in the fluid reservoir maintains the gear pump in a primed state. A fluid line (30) leading from the gear pump to a sprayer head has a discharge check valve (34) located therein.      The check valve has a cracking pressure higher than the static head of fluid so that fluid passes to the sprayer head only when the gear pump operates to increase pressure in the fluid line above the cracking pressure. There is also means for powering and operating the motor such that the gear pump provides a continuous flow of fluid to the sprayer head upon demand by a user.
Patent CA-2353735-A1 (CA)
Title: Stand alone water purifier
Inventor: JOHNSON JEFFREY D
IPC: B01D15/00
Filed: 2001-07-25
Abstract: A water purification device, method and system with the water purification device having a container for holding a water purification material therein with the water purification device including a shroud extending in a direction generally normal to a flow of debris laden water with the shroud inhibiting direct flow of debris into a water inlet in the water purification device by directing water and debris over the shroud and around the water purification device while a portion of the water can be directed laterally into the water purification material within the water purification device to thereby purify the water that flows over the water purification materials with the water purification device including multiple spaced and positioned water inlets so that the likelihood of the water inlet being completely obstructed is remote.
Patent CA-2357560-A1 (CA)
Title: Methods of cementing in subterranean zones
Inventor: REDDY B RAGHAVA
IPC: C04B28/02
Filed: 2001-09-17
Abstract: Improved methods of cementing in subterranean zones penetrated by well bores are provided. The methods are basically comprised of the steps of preparing a cement composition comprised of a hydraulic cement, a biodegradable, substantially non-dispersing set retarder of low anionic character comprised of polysuccinimide and sufficient water to form a slurry, placing said cement composition in said subterranean zone and allowing said cement composition to set into a solid mass therein.
Patent CA-2357818-A1 (CA)
Title: Multi-well plate cover and assembly adapted for mechanical manipulation
Inventor: HALL JOHN P
IPC: B01L3/00
Filed: 2001-09-26
Abstract: A multi-well plate cover and assembly comprises a lid and gasket. The lid has integral spring means for uniformly applying force to the surface of a gasket to seal a multi-well plate. The lid has members for mechanical manipulation and for attachment to a multi-well plate.
Patent CA-2358285-A1 (CA)
Title: Method and kit for extracting prion protein
Inventor: SCHMERR MARY JO
IPC: C12P21/00
Filed: 2000-01-07
Abstract: A method for extracting prion protein from a biological material, e.g., an animal tissue or product. In a specific example, abnormal prion protein is extracted from homogenized sheep brain with hexafluoro-2-propanol. The hexafluoro-2-propanol is separated from the aqueous brain preparation by increasing the ionic strength of the aqueous solution. Prion protein in the organic extract can be further purified, or the extract can be tested, e.g.,  by immunoassay, for the presence of prion protein, and more particularly abnormal prion protein. The extraction process permits testing for the presence of abnormal prion protein, e.g., for diagnosis of transmissible spongiform encephalopathies (TSE). The figure shows chromatogram from HILIC of I-prion protein as detected by radioactivity which is represented by open circles and by absorbance at 280 nm as represented by solid line in the grap h.