baber/WOPTO huggingface dataset:
Patent CA-3067008-A1 (CA)
Title: Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
Inventor: SONI PARESH
IPC: A61P9/10
Filed: 2013-06-28
Abstract: In various embodiments, the present invention provides methods of reducing the risk of unstable angina in a subject on statin therapy and, in particular, a method of reducing the risk of a cardiovascular event in a subject on statin therapy having a fasting baseline triglyceride level of about 135 mg/dL to about 500 mg/dL, and administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof
Patent CA-3067428-A1 (CA)
Title: Driver tool and method
Inventor: GOODWIN JR
IPC: B25B23/14
Filed: 2018-06-25
Abstract: In one aspect, a surgical driver is provided that includes a driver shaft, a handle rotatably connected to the driver shaft, and a resilient, elongate pin extending transverse to the driver shaft. The pin is operably engaged with the driver shaft and the handle so that torque applied to the handle causes turning of the driver shaft. The pin is configured to deflect to limit the torque applied to the driver shaft.
Patent CA-3067503-A1 (CA)
Title: Beneficiation of values from ores with a heap leach process
Inventor: FILMER ANTHONY OWEN
IPC: C22B3/04
Filed: 2018-05-15
Abstract: This invention relates to a process for recovering value metals from sulphide ore, including steps of crushing ore in a primary crusher (14) to a size of about 40cm and less, passing the crushed ore through one or more of the following pre-beneficiation processes such as bulk sorting (16) and screening (20) followed by coarse floatation (46/50), or gravity separation or magnetic separation. A waste stream (54) from the pre-beneficiation process/es with a particle size greater than 100µm is stacked in a heap (26) and subjected to a heap leach. This integrated process utilises the pre-beneficiation techniques best suited to the characteristics of a particular orebody; and during the pre-beneficiation simultaneously creating a low grade stream that yields significantly higher recoveries than achievable by normal heap leaching of low grade run of mine ore.
Patent CA-3068038-A1 (CA)
Title: Sandwich-type assays using decreasing signal portions of dose response curve to measure analytes, including analytes at high concentration
Inventor: YANG JIAN
IPC: G01N33/552
Filed: 2018-06-25
Abstract: Sandwich-type lateral flow assay devices, systems, and methods described herein measure concentration of an analyte of interest in a sample, and can determine the precise concentration of the analyte when it is present at high concentrations. A signal of maximum intensity is generated when the concentration of analyte of interest in a sample is zero. For low concentrations of analyte, the lateral flow assays described herein generate signals that are the same as or substantially equivalent to the maximum intensity signal. High concentrations of the analyte of interest generate signals that are less than the maximum intensity signal. Lateral flow assays of the present disclosure solve drawbacks associated with the hook effect of sandwich-type lateral flow assays by eliminating the phase of the dose response curve where signals are increasing.
Patent CA-3068066-A1 (CA)
Inventor: DENSON JESSE
IPC: A61H9/00
Filed: 2018-06-28
Abstract: L'invention concerne la surveillance des paramètres vitaux d'un porteur d'un vêtement de compression par l'analyse d'une forme d'onde de signal de pression indiquant une pression d'un fluide dans une poche gonflable et dégonflable du vêtement de compression. L'analyse de la forme d'onde de signal de pression pour une amplitude d'oscillation en fonction du temps et/ou une représentation d'un pouls de l'utilisateur fournit une indication de la pression artérielle du porteur.
Patent CA-3069515-A1 (CA)
Inventor: CANTLEY LEWIS C
IPC: A61K31/00
Filed: 2018-07-10
Abstract: As described herein, chromosomal missegregations, chromosomal micronuclei, cytosolic DNA, and combinations thereof are indicative of metastatic cancer. Methods and compositions are described herein that are useful for detection and treatment of patients with chromosomal instabilities such as chromosomal missegregations, chromosomal micronuclei, cytosolic DNA, and combinations thereof. For example, some of the methods and compositions include use of kinesin-13 proteins such as Kif2b, MCAK/Kif2c, or KIF13A. The methods and compositions can also include inhibitors of STING, ENPP1, cGAS, NF-kB transcription factor p52, NF-kB transcription factor RelB, or any combination thereof. Methods are also described for identifying compounds that are effective for treatment of cancer, including metastatic cancer.
Patent CA-3070210-A1 (CA)
Title: Peptide derivative and pharmaceutical composition containing same
Inventor: KATAGIRI TOYOMASA
IPC: A61K38/10
Filed: 2018-07-18
Abstract: The present invention provides a peptide having a structure in which a portion of a dominant-negative peptide of BIG3 which inhibits interaction between BIG3 and PHB2, is replaced by at least two stapling structures. The peptide according to the present invention has excellent cell growth inhibiting activity. The cell growth inhibiting activity is sustained for a long period of time, compared to a single-stapled peptide. Therefore, the peptide according to the present invention has a feature suitable for clinical applications in cancer therapy.
Patent CA-3071314-A1 (CA)
Title: Nouveaux systemes de batterie fondes sur le difluorophosphate de lithium utilisant le methyle, l'acetate, le solvant carbonate et l'oxyde de lithium-manganese-cobalt
Inventor: MA LIN
IPC: H01M10/0525
Filed: 2018-07-31
Abstract: Un électrolyte non aqueux pour une batterie au lithium-ion comprend un sel de lithium, un premier solvant non aqueux et un mélange d'additifs comprenant un premier additif fonctionnel de difluorophosphate de lithium et un second additif fonctionnel de carbonate d'éthylène fluoré ou de carbonate de vinylène. Une batterie au lithium-ion comprend une électrode négative, une électrode positive comprenant du NMC avec des grains à échelle micrométrique, un électrolyte non aqueux ayant des ions lithium dissous dans un premier solvant non aqueux, et un mélange d'additifs ayant un premier additif fonctionnel de carbonate d'éthylène fluoré ou de carbonate de vinylène et un second additif fonctionnel constitué soit de 1,3,2-dioxathiolane-2,2-dioxyde, d'un autre additif contenant du soufre, soit du difluorophosphate de lithium.
Patent CA-3074875-A1 (CA)
Inventor: SONNIER GARETH DUSTIN
IPC: B65H51/18
Filed: 2018-09-05
Abstract: A tubular gripping die is presented, the die comprising one or more axial load teeth and one or more torqueing teeth. A method of manufacturing a tubular gripping die is also presented. The method includes forming one or more axial load teeth extending from a base of the die; forming one or more torqueing teeth extending from the base of the die; and defining a gripping front face of the die, at least a portion of the gripping front face having a concave curvature to align with an outside diameter of the tubular to be gripped. The portion of the gripping front face formed with the curvature comprises any one of said axial load teeth, said torqueing teeth or both. A method of making up a tubular string from a plurality of tubular joints is also presented. A tubular handing tool comprising one of more tubular gripping dies, each die comprising one or more axial load teeth and one or more torqueing teeth arranged thereon.
Patent CA-3076149-A1 (CA)
Inventor: DUMAS FRANCOIS-CHARLES
IPC: F16D48/12
Filed: 2018-09-13
Abstract: A vehicle has an engine, an accelerator control, a limited slip differential (LSD) mounted on an axle driven by the engine, and left and right wheels operably connected to the LSD. An accelerator control position is sensed. A speed of the vehicle is optionally sensed. In order to prevent wheel spin, a high load is selectively applied to the LSD when the accelerator control position meets or exceeds a predetermined position threshold. Optionally, application of the high load may depend on the speed of the vehicle being less than a predetermined speed threshold, the accelerator control position concurrently meeting or exceeding the predetermined position threshold. In order to enhance directional stability of the vehicle, a stabilization load is optionally applied when the speed of the vehicle meets or exceeds the predetermined speed threshold.
Patent CA-3078408-A1 (CA)
Inventor: DELUCA HECTOR F
IPC: A61P3/02
Filed: 2018-10-16
Abstract: L'invention concerne des procédés de purification du composé (22E)-(24R)-2-méthylène-22-déhydro-1a,24,25-trihydroxy-19-nor-vitamine D3 pour obtenir le composé sous forme cristalline. Les procédés comprennent typiquement les étapes de dissolution de (22E)-(24R)-2-méthylène-22-déhydro-1a,24,25-trihydroxy-19-nor-vitamine D3 dans un solvant comprenant de l'acétate d'éthyle et de l'hexane pour former une solution, permettant aux cristaux de (22E)-(24R)-2-méthylène-22-déhydro-1a,24,25-trihydroxy-19-nor-vitamine D3 de former et précipiter à partir de la solution, et récupérer les cristaux de (22E)-(24R)-2-méthylène-22-déhydro-1a,24,25-trihydroxy-19-nor-vitamine D3 à partir de la solution.
Patent CA-3081439-A1 (CA)
Title: Storage rack for mine tools with enhanced connectivity and related methods
Inventor: HUNT DOUGLAS S
IPC: E21C35/00
Filed: 2020-05-29
Abstract: An apparatus for use with a mining machine for storing tools in a convenient manner. A  first mining tool includes a first connector adapted to connect with the mining machine, such as by connecting parallel bars with receivers on a head end of a boom. A storage rack is provided for storing the first mining tool in a manner that facilitates ready attachment with the mining machine.  The storage rack also includes a second connector adapted to connect itself with the mining machine, which may be by connecting parallel bars with receivers on a head end of a boom, similar to the manner in which the first mining tool is connected. Related methods are also disclosed.
Patent CA-3081471-A1 (CA)
Title: Dispositif de test de structure
Inventor: ROSEMEIER MALO
IPC: G01M5/00
Filed: 2018-11-02
Abstract: L'invention concerne un banc d'essai comprenant un support (19, 25) relié de manière mobile à une paroi (18, 18', 18''), un fond, un cadre (26) du banc d'essai ou une autre partie du banc d'essai et mobile sur une piste prédéterminée ; un actionneur (22) qui est relié au support et au moyen duquel le support (19, 25) peut être déplacé sur la piste prédéterminée, deux dispositifs de serrage (13) comprenant chacun une articulation à rotule. Un premier des deux dispositifs de serrage (13) est fixé au support (19, 25) et un deuxième des deux dispositifs de serrage (13) est disposé dans un axe (10) avec le premier des deux dispositifs de serrage (13) de sorte qu'entre les deux dispositifs de serrage (13), un corps de test (1) soit serré sur des surfaces extérieures de corps de test et puisse être maintenu par les dispositifs de serrage (13) et une force de test exercée par un corps de test par déplacement du support (19, 25) à travers le premier des deux dispositifs de serrage (13) agit sensiblement le long de l'axe (10). Le corps de test est fixé par un élément élastique (23) pour limiter la rotation du corps de test sur l'axe (10).
Patent CA-3083925-A1 (CA)
Title: Systems and methods for securely processing content
Inventor: MORROW ANDREW
IPC: H04L9/14
Filed: 2020-06-18
Abstract: A device may not trust another device with which it is in communication. To establish trust, a first device may send a second device an indication of signed code that is stored in a protected memory of the first device. Based on determining that the first device is a trusted device, the second device may send the first device an encrypted content asset, a decryption key associated with the content asset, and/or an encryption key associated with the content asset.
Patent CA-3086024-A1 (CA)
Title: Composition for suppressing fat accumulation
Inventor: SUGIYAMA MASANORI
IPC: A61P1/16
Filed: 2019-04-04
Abstract: This composition, which contains, as active ingredients, microbial cells of a lactobacilli belonging to Lactobacillus paracasei, a cultured product or fermented product thereof, or a polysaccharide produced by the same, is effective for inhibiting fat accumulation, and can be used as food, medication, and animal food for preventing or alleviating obesity, fatty liver, or hepatic failure.
Patent CA-3086254-A1 (CA)
Title: A laser-based device for mapping a computed geometry relative to a reference geometry
Inventor: LI LUN
IPC: G01S17/48
Filed: 2018-03-29
Abstract: System, method and device for identifying a location of interest. A laser rangefinder is rotatable to a plurality of reference orientations to measure a plurality of reference distances to environmental surface points. The reference distances and reference orientations are used to define a reference plane. A geometrical surface of interest is identified relative to the reference plane. The laser rangefinder is further rotatable to interrogation orientations to measure interrogation distances to interrogation surface points. The spatial coordinates of the interrogation surface point are determined from the interrogation distance and the interrogation orientation and compared to a spatial model of the surface of interest to determine if the interrogation locations are on the surface of interest. Feedback is generated indicating whether the interrogated surface point is a location of interest.
Patent CA-3089712-A1 (CA)
Title: Methods and compositions for treating sleep apnea
Inventor: MILLER LAWRENCE G
IPC: A61K45/06
Filed: 2019-01-30
Abstract: In general, the invention relates to pharmaceutical compositions comprising (R)- oxybutynin and a norepinephrine reuptake inhibitor (NRI) and methods of treating Sleep Apnea comprising administering (R)-oxybutynin and a norepinephrine reuptake inhibitor (NRI). In some embodiments, the NRI is atomoxetine.
Patent CA-3092030-A1 (CA)
Title: Non-leaching styrene-free cured-in-place pipe system suitable for potable water applications
Inventor: MILLER GREGORY C
IPC: C08F283/01
Filed: 2019-02-06
Abstract: Styrene-free unsaturated polyester resin and vinyl ester resin compositions are provided which contain low amounts of hazardous air pollutants, good mechanical and physical properties, and good corrosion resistant characteristics. The resin systems are such that minimal or no component is leachable after completion of the curing process. The resins are suitable for repair of sewer pipes and potable water pipe systems as part of a cured-in-place pipe application. Additionally, the invention is suitable for relining of storage tanks. A process for the manufacture of these resin compositions is also provided.
Patent CA-3096870-A1 (CA)
Title: Agregat cellulaire, melange d'agregats cellulaires et sa methode de preparation
Inventor: YOSHIDA KENJI
IPC: A61P9/10
Filed: 2019-02-18
Abstract: L'objectif de la présente invention est de fournir : un agrégat cellulaire contenant des cellules précurseurs neurales produisant de la dopamine appropriées pour une transplantation; un mélange associé; et une méthode de préparation associée. Cet agrégat cellulaire contient des cellules du système nerveux FOXA2 positives ou des cellules du système nerveux TUJ1 positives et contient 1000 cellules ou plus.
Patent CA-3101192-A1 (CA)
Title: System for positioning animal tags, method of determining a location of an intermediate base station and a computer program therefor
Inventor: FLORCZAK KELD
IPC: G01S5/02
Filed: 2019-05-20
Abstract: At least three anchor base stations (BSA1, BSA2, BSA3, BSA4) are arranged in a frame a of common plane around an area in which positions for animal tags are to be determined based on propagation-delay measurements of signals emitted by the animal tags using a global time reference. The anchor base stations have known respective locations, and the location of an intermediate base station (BSI5) added to the system is determined by: (a) arranging the intermediate base station (BSI5) between first and second anchor base stations (BSA1, BSA3), such that in the common plane, the intermediate base station (BSI5) is located on a straight line between the anchor base stations; (b) determining, based on propagation-delay measurements of a signal emitted by the intermediate base station (BSI5) and using the global time reference (b1 ) a first calculated distance between the first anchor base station (BSA1 ) and the intermediate base station (BSI5), and (b2) a second calculated distance between the second anchor base station (BSA3) and the intermediate base station (BSI5); (c) obtaining an elevation indicator specifying whether the intermediate base station (BSI5) is located in level with, above or below the common plane; and (d) determining the location of the intermediate base station (BSI5) based on the first and second calculated distances and the elevation indicator.
Patent CA-3102985-A1 (CA)
Inventor: TANABE SHINTARO
IPC: C07C271/16
Filed: 2019-06-07
Abstract: The present invention addresses the problem of providing: a compound or a salt thereof, which constitutes lipid particles that enable the achievement of high nucleic acid encapsulation rate and excellent nucleic acid delivery; and lipid particles which use this compound or a salt thereof, and which enable the achievement of high nucleic acid encapsulation rate and excellent nucleic acid delivery. The present invention provides a compound represented by formula (1) or a salt thereof. In the formula, X represents -NR1- or -O-; R1 represents a hydrogen atom, a hydrocarbon group or the like; each of R2 and R3 independently represents a hydrogen atom, a hydrocarbon group or the like; each of R4, R5, R6, R7, R8, R9, R10, R11 and R12 independently represents a hydrogen atom, an alkyl group or the like; one or more pairs selected from among a pair of R4 and R5, a pair of R10 and R5, a pair of R5 and R12, a pair of R4 and R6, a pair of R5 and R6, a pair of R6 and R7, a pair of R6 and R10, a pair of R12 and R7, and a pair of R7 and R8 may combine with each other and form a 4- to 7-membered ring that may contain an O atom; and each of a, b, c and d independently represents an integer of 0-3, provided that (a + b) is 1 or more and (c + d) is 1 or more.
Patent CA-3106718-A1 (CA)
Inventor: COLE RUSSELL
IPC: A61M5/142
Filed: 2015-04-23
Abstract: Abstract of the Disclosure A cannula insertion device (1) is disclosed. The device includes a needle carriage (10), a rail device (82, 84, 86, 88) on which the needle carriage (10) is slidable, a yoke (54) having a channel (546), a linkage (20) connected to the needle carriage (10) and extending into the channel (546), a torsion spring (30) with one end connected to the linkage (20), and locking device (90) for locking the torsion spring (30) in tension and maintaining the needle carriage (10) and the linkage (20) in a locked position prior to activation. Upon release of the locking device (90), the tension of the torsion spring (30) is released, which causes the linkage (20) to move in the channel (546) and slide the needle carriage (10) along the rail device (82, 84, 86, 88). A catheter carriage (60) may also be provided for actuation by the linkage (20). Date Recue/Date Received 2021-01-21
Patent CA-3109653-A1 (CA)
Inventor: PETERSON ALEX A
IPC: A61M25/10
Filed: 2019-09-04
Abstract: La présente invention concerne un dispositif et une méthode de régulation de manière prévisible du repliement d'une endoprothèse repliable et extensible pour une translation ultérieure à travers une lumière de gaine de pose vers une cible anatomique telle qu'une valvule cardiaque ou un emplacement intravasculaire pour une extension et une implantation. Le dispositif de chargement est défini par une lumière interne comprenant un diamètre interne successivement décroissant, de la direction allant de l'extrémité proximale à l'extrémité distale, alternant entre deux sections de diamètre décroissant et deux sections de diamètre constant jusqu'à atteindre le diamètre interne de la gaine de pose. Un réservoir rempli de fluide est disposé au niveau de l'extrémité proximale du dispositif de chargement qui est conçu pour fournir de l'humidité ou un mouillage pour des matériaux associés à l'endoprothèse, ou fixés à celle-ci, qui nécessitent une rétention d'humidité. Ainsi, lorsque l'endoprothèse est repliée avec le dispositif de chargement, au moins une partie de l'endoprothèse peut être immergée dans le réservoir de fluide pour conserver le matériau selon l'invention.
Patent CA-3110277-A1 (CA)
Inventor: LIAN XIAOJUN
IPC: C12N5/074
Filed: 2019-08-22
Abstract: Provided are methods, compositions and kits for generating beta cells from pluripotent stem cells under growth-factor free, defined culture conditions. The beta cells can be generated under conditions that are free of animal products. The generated beta cells secrete insulin, not glucagon, and the amount of insulin secreted is dependent upon the level of glucose stimulus.
Patent CA-3110567-A1 (CA)
Inventor: BOUDREAULT JEAN-DENIS
IPC: G06F16/21
Filed: 2019-08-28
Abstract: A method and system for validating execution of a smart contract comprises storing the smart contract within a blockchain having at least one first order block. The smart contract has a set of electronically-defined contract clauses, each being defined by at least one satisfaction value, and the combination of the satisfaction values of the set of contract clauses having a satisfaction hash value for the contract. A set of one or more electronically-stored second order transactions each having a subset of one or more execution values is read and a subset of transactions corresponding to the contract clauses are selected. An execution hash value of the combination of execution values of the subset of transaction is determined. A smart contract is considered as fully executed if the execution hash value of the combination of execution values of the subset of transactions matches the satisfaction hash value of the smart contract.
Patent CA-3111344-A1 (CA)
Title: Production of a coil, permanent mold for a coil, and coil
Inventor: WOSTMANN FRANZ-JOSEF
IPC: B22D31/00
Filed: 2019-09-19
Abstract: The invention relates to a method for producing a coil (2). A permanent mold with mold halves which can be joined together on a mold separation plane is provided. The mold halves of the permanent mold are joined together such that the permanent mold has a cavity, which defines the shape of the coil (2) or the shape of a bent open coil, when the permanent mold is joined together. The specified coil (2) or the bent open coil has a flattened profiled winding cross-section which has two opposite flat faces (2.1, 2.1'), an outer face and an inner face (2.3) opposite the outer face. The mold separation plane runs at least partly along the flat faces (2.1, 2.1') from the inner face to the outer face (2.3), wherein the permanent mold has a bulge (2.5) which extends along the mold separation plane and protrudes into the cavity at least in a region in which the mold separation plane runs along one of the flat faces (2.1, 2.1') such that the cast body is provided with recesses (2.5) on the flat faces (2.1, 2.1'). The invention further relates to a permanent mold for carrying out the method and to a coil which has been produced using the method or using the permanent mold.
Patent CA-3115463-A1 (CA)
Title: Dispositifs medicaux pour la gestion des voies respiratoires et procedes de mise en place
Inventor: MOLNAR ROBERT W
IPC: A61B1/018
Filed: 2019-10-08
Abstract: L'invention concerne des dispositifs médicaux, notamment des dispositifs oraux pour voies respiratoires, qui sont compatibles avec une caméra pour la ventilation, l'intubation et l'extubation d'un patient sous visualisation continue. L'invention concerne également des méthodes de ventilation, d'intubation et d'extubation d'un patient avec les dispositifs médicaux.