Patent CA-3015293-A1 (CA)
Inventor: BICKNELL ROY
IPC: A61K39/395
Filed: 2017-03-14
Abstract: CA 03015293 2018-08-21 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization MINNIE 0 Hi 010 lll 010 HI 0 l 01 HMI 1011 00111M0 1111 OEN International Bureau (10) International Publication Number (43) International Publication Date WO 2017/158337 Al 21 September 2017 (21.09.2017) WIPO I PCT (51) International Patent Classification: (74) Agent: ALBUTT, Jodie; Cell Therapy Catapult Limited, C07K 16/28 (2006.01) A61K 39/395 (2006.01) 12th Floor, Tower Wing, Guy's Hospital, Great Maze Pond, London SE1 9RT (GB). (21) International Application Number: PCT/GB2017/050686 (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, 14 March 2017 (14.03.2017) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (26) Publication Language: English KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (30) Priority Data: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 1604387.9 15 March 2016 (15.03.2016) GB NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 1612533.8 19 July 2016 (19.07.2016) GB RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 1612844.9 25 July 2016 (25.07.2016) GB TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicants: CANCER RESEARCH TECHNOLOGY LIMITED [GB/GB]; Angel Building, 407 St John Street, (84) Designated States (unless otherwise indicated, for every London EC1V 4AD (GB). THE UNIVERSITY OF kind of regional protection available): ARIPO (BW, GH, BIRMINGHAM [GB/GB]; Edgbaston, Birmingham West GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Midlands B15 2TT (GB). CELL THERAPY CATA-TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, PULT LIMITED [GB/GB]; 12th Floor, Tower Wing, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Guys Hospital, Great Maze Pond, London SE1 9RT (GB). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, ' LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, = (72) Inventors: BICKNELL, Roy; 7 Barnsley Road, Edgba- SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, ston, Birmingham West Midlands B17 8EB (GB). LEE, GW, KM, ML, MR, NE, SN, TD, TG). Steven; 120 Grove Road, Kings Heath, Birmingham West Published: Midlands B14 65Y (GB). MOUNT, Natalie; Cell Therapy Catapult Limited, 12th Floor, Tower Wing, Guy's Hospital, ¨ with international search report (Art. 21(3)) Great Maze Pond, London SE1 9RT (GB). SHARPE, Mi-. ¨ before the expiration of the time limit for amending the chaela; Cell Therapy Catapult Limited, 12th Floor, Tower claims and to be republished in the event of receipt of Wing, Guy's Hospital, Great Maze Pond, London SE1 9RT amendments (Rule 48.2(h)) (GB). ¨ with sequence listing part of description (Rule 5.2(a)) 1-1 cc ______________________________________________________________________________ 11 1-1 (54) Title: CHIMERIC ANTIGEN RECEPTOR IN (57) Abstract: The present invention is directed to a nucleic acid molecule comprising a polynucleotide sequence encoding a chi -I-1 meric antigen receptor comprising (a) an anti-CLEC14A binding domain, (b) a transmembrane domain and (c) an intracellular sig -el nalling domain; wherein said anti-CLEC14A binding domain is capable of binding to the C- type lectin domain of CLEC14A. The en.) invention further provides a chimeric antigen receptor encoded by the nucleic acid molecule, a vector comprising the nucleic acid molecule, a cell comprising the nucleic acid molecule, vector or CAR and the therapeutic use of the nucleic acid, vector or cell, par ticularly in treating CLEC14A expressing conditions.