Patent SG-11201900427P-A (SG)
Title: Fusion proteins of human protein fragments to create orderly multimerized immunoglobulin fc compositions with enhanced fc receptor binding
Inventor: BLOCK DAVID S
IPC: C07K14/47
Filed: 2017-07-24
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 01111111111111111111111111111 111E1111 0111111 Organization International Bureau (10) International Publication Number 0 (43) International Publication Date .....0\"\" WO 2018/018047 A3 25 January 2018 (25.01.2018) WIP0 I PCT (51) (21) (22) (25) Filing Language: (26) (30) (71) (72) International Patent Classification: A61K 39/395 (2006.01) CO7K 14/47 A61K 45/06 (2006.01) International Application Number: International Filing Date: 24 July 2017 (24.07.2017) Publication Language: Priority Data: 62/365,921 22 July 2016 (22.07.2016) 62/365,919 22 July 2016 (22.07.2016) Applicant: GLIKNIK INC. [US/US]; Street, Suite 501A, Baltimore, Maryland 21201 (US). Inventors: BLOCK, David S.; c/o Baltimore Street, Suite 501A, Baltimore, (US). OLSEN, Henrik; c/o Gliknik Inc., PCT/US2017/043538 (74) (2006.01) (81) English English US US 801 W. Baltimore (84) Gliknik Inc., 801 W. Agent: PHELAN, Jordan D. et al.; Cooley LLP, 1299 Pennsylvania Avenue, NW, Suite 700, Washington, District of Columbia 20004 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Maryland 21201 801 W. Baltimore 21201 (US). Street, Suite 501A, Baltimore, Maryland = = = the (54) present 0 multimeric Title: FUSION PROTEINS OF HUMAN FC COMPOSITIONS WITH ENHANCED FC RECEPTOR GL2045 Fc7R1 MUNOGLOBULIN PROTEIN FRAGMENTS FIG. Fc7R118 .,........— ,..._ 1 TO CREATE ORDERLY MULTIMERIZED BINDING FeyRITIA F cyR.IIA .... - IM- thereby ordered useful — = = = = = = = = = = _ = ... ,. M IN 7r CZ GC 11 CZ --- -- GO (57) \" in : The present invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly fractions, termed stradomers. The invention involves fusion proteins that bind to FcyRs and complement and that are treatment and prevention of disease. [Continued on next page] WO 2018/018047 A3 MUNRO DOI 01011MERIONIMOHMONHOHMIN TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a)) (88) Date of publication of the international search report: 01 March 2018 (01.03.2018)