baber/WOPTO huggingface dataset:
Patent CA-3116091-A1 (CA)
Title: Method for the treatment of myasthenia gravis
Inventor: BROCK MELISSA KAYE
IPC: A61K39/395
Filed: 2019-10-16
Abstract: The disclosure relates to a method of treating or preventing Myasthenia Gravis (MG) in a human in need thereof using an anti-FcRn antibody or antigen binding fragment thereof. In particular, the method provides suitable dosage regimens for such treatment.
Patent CA-3116994-A1 (CA)
Inventor: QIN YUANBO
IPC: C12N15/09
Filed: 2019-10-24
Abstract: The present invention relates to a protein which is composed of a sequence comprising such an amino acid sequence that there is a contiguously deleted region between position-721 and position-755 in the amino acid sequence represented by SEQ ID NO: 2 and amino acid residues that are respectively adjacent to the deleted region are linked to each other through a linker composed of 3 to 10 amino acid residues, and which has an ability to bind to guide RNA. The protein maintains the guide RNA-binding ability and the DNA binding affinity thereof, in spite of the fact that the protein has the deleted region and is therefore miniaturized compared with full-length dSaCas9. The use of the miniaturized dSaCas9 protein makes it possible to package a larger number of genes in a vector.
Patent CA-3117963-A1 (CA)
Title: Devices and methods for automatic suture
Inventor: GURU KHURSHID
IPC: A61B17/29
Filed: 2019-10-30
Abstract: A method includes engaging a clamp over a length of tissue to be sutured. A helical needle is advanced along a length of the clamp such that the helical needle passes through the tissue to be sutured. A leading end of a suturing thread is attached at a tip of the helical needle. The leading end of the suturing thread is captured. The helical needle is retracted back through the tissue so as to leave the thread in place. The clamp is disengaged from the tissue. A device for automatic suturing includes a clamp configured to be positioned over a length of tissues to be sutured. A helical needle is configured to be advanced and retracted along a length of the clamp. The needle has a tip. A suturing thread having a leading end is attached to the tip of the helical needle.
Patent CA-3117976-A1 (CA)
Title: Mist humidifier blower methods and systems
Inventor: Lotfi Shahram
IPC: F24F1/028
Filed: 2019-07-09
Abstract: ABSTRACT Mist based humidification systems are employed in numerous environments. However, such systems are typically small portable units whilst it would be beneficial to employ ultrasonic based mist humidifiers in larger environments. However, these environments introduce additional requirements such as reducing the emission / distribution of condensed water as droplets from the humidifier, allowing independent placement of the mist generator from the mist distribution element(s), and the requirement to "throw" the mist a reasonable distance into the environment rather than relying upon the circulation within the environment to achieve distribution. Embodiments of the invention address these issues whilst also supporting modular humidification systems operating at multiple capacities. Date Recue/Date Received 2021-05-11
Patent CA-3118570-A1 (CA)
Inventor: GEIGER RONNY
IPC: F04D7/04
Filed: 2019-11-28
Abstract: La présente invention concerne un agencement et un procédé de commande d'un flux de gaz séparé d'une suspension de pâte à consistance moyenne. La pâte est traitée dans un appareil de traitement de pâte comprenant au moins une première pompe et une seconde pompe, la seconde pompe étant une pompe centrifuge de dégazage pourvue d'un système de dégazage qui comprend un conduit de dégazage dans lequel une soupape de dégazage est agencée pour réguler une différence de pression entre une entrée de la seconde pompe et le conduit de dégazage. Le système de dégazage comprend en outre un récipient de dégazage sous pression fonctionnant en surpression et comprenant une entrée et une sortie, la sortie du récipient étant reliée à une soupape de commande de pression pour maintenir une surpression souhaitée dans le récipient.
Patent CA-3118738-A1 (CA)
Inventor: LEE MATTHEW RANDOLPH
IPC: A61K31/4725
Filed: 2019-11-06
Abstract: The present invention relates to compounds that inhibit ROCK activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.
Patent CA-3118768-A1 (CA)
Inventor: DING SANSAN
IPC: B61D17/04
Filed: 2020-04-22
Abstract: A rail vehicle body structure, comprising: a tubular corrugated plate (1); an annular beam (2) and an underframe cross beam (3) sleeved within the corrugated plate (1); and underframe side beams (4) provided between the annular beam (2) and the underframe cross beam (3). The two sides of the bottom of the corrugated plate (1) are symmetrically provided with connection parts (12), and the underframe side beam (4) is disposed on the outside of the connection part (12).
Patent CA-3119375-A1 (CA)
Inventor: GREEN DAVID
IPC: B62B1/00
Filed: 2021-05-21
Abstract: According to some embodiments, there is provided a wheel storage apparatus comprising a frame having a loading platform, a wheel supporting platform and a handle section. When the wheel storage apparatus is in a first orientation, the loading platform is generally parallel with and at a loading height from a loading surface and configured to cradle a plurality of wheels about a circumferential portion of each wheel. The wheel supporting platform is coupled to a first end of the loading platform and configured to support the wheels in a stacked configuration when the wheel storage apparatus is in a second orientation. The wheel storage apparatus is configured to rotate from the first orientation to the storage orientation about a pivot axis proximate the first end of the loading platform. Kits for wheel storage apparatus are also described.
Patent CA-3121559-A1 (CA)
Inventor: Breakfield Natalie
IPC: A01N25/04
Filed: 2019-12-02
Abstract: La présente invention concerne des compositions pour l'amélioration du rendement comprenant du Methylobacterium ; des procédés pour améliorer le rendement du maïs, et des procédés de production de ces compositions. L'invention porte également sur des Methylobacterium isolés permettant l'amélioration du rendement.
Patent CA-3122173-A1 (CA)
Title: Computing resource allocation
Inventor: DOBSON MATTHEW CARLSON
IPC: G06F9/50
Filed: 2019-12-09
Abstract: There is provided a method of computing resource allocation. The method comprises allocating a first bounded amount of computing resources forming a first set of computing resources; exclusively assigning the first set of computing resources to a first process of a computer program; receiving a request from the first process for additional computing resources; in response to the request from the first process, allocating a second bounded amount of computing resources forming a second set of computing resources; and spawning a second process from the first process and exclusively assigning the second set of computing resources to the second process; wherein this method may be repeated indefinitely by the first process, second process, or any other process created according to this method. By following this method, a process does not control the amount of computing resources allocated to that process (i.e., itself), but instead controls the amount of computing resources allocated to its child processes.
Patent CA-3124450-A1 (CA)
Title: User module for a patient support apparatus
Inventor: NAHAVANDI KUROSH
IPC: A61G7/05
Filed: 2019-12-19
Abstract: A patient support apparatus comprises a support structure, a user module, and a controller. The user module comprises a display and indicator panel that has a plurality of indicia, each associated with a monitored condition. First light emitters are arranged to project light to illuminate the indicia and second light emitters are arranged to project light off a reflective surface. The controller is coupled to the display and the light emitters, and is configured to, in response to a change in a state of one of the monitored conditions, generate on the display a state indicator corresponding to the change in the state and activate the light emitters such that a color of the light projected by the light emitters matches a color of the state indicator.
Patent CA-3130872-A1 (CA)
Inventor: REHM ARMIN
IPC: C12N5/10
Filed: 2020-03-25
Abstract: The invention relates to a genetically modified cytotoxic T cell comprising one or more exogenous nucleic acid molecules encoding a transgenic antigen-targeting construct, wherein in said cells estrogen receptor-binding fragment-associated antigen 9 (EBAG9) activity is inhibited. The invention relates further to the modified cytotoxic T cell in which the antigen-targeting construct is a chimeric antigen receptor (CAR) or T cell receptor (TCR). The invention further relates to the modified T cell for use as a medicament in the treatment of a proliferative disease, and corresponding methods of treatment, in particular for the treatment of hematologic malignancies. The invention relates further to a pharmaceutical composition comprising the modified T cell, a nucleic acid vector encoding the antigen-targeting construct and means for inhibiting EBAG9, preferably using RNA interference, and to an in vitro method for increasing the cytolytic activity of a cytotoxic T cell.
Patent CA-3133415-A1 (CA)
Inventor: CHANG JUNBIAO
IPC: A61K31/7068
Filed: 2019-04-18
Abstract: Disclosed is a crystal form A of a 2'-fluoro-4'-substituted nucleoside analog I, Azvudine . The crystal form A has the following structure: The CuKa-XRPD pattern of the crystal form A of the compound I is as shown in figure 2, the crystal form A has a good stability and can easily be uniformly mixed with auxiliary materials. The crystal form A of the compound I is mixed with the auxiliary materials, so that the uniformity thereof in tablets is increased, and same is conducive to controlling the drug quality and ensuring the drug efficacy. The crystal form A is used for preparing anti-HBV or anti-HCV or anti-HIV drugs or anti-tumor drugs.
Patent CA-3134013-A1 (CA)
Inventor: DESHPANDE PRASHANT
IPC: F25D31/00
Filed: 2020-03-31
Abstract: A cooler for storing beverage containers. The cooler includes a housing defining an interior volume for storing a first beverage container at a first predetermined temperature and a compartment within the interior volume of the housing for storing a second beverage container at a second predetermined temperature that is at or below a freezing point of the beverage. The cooler further includes a user interface for receiving a user input to dispense the second beverage container, and a delivery portal for providing access to the second beverage container. A chute is configured to communicate the second beverage container from the compartment to the delivery portal and to cause nucleation of the beverage and form a slush beverage. A cooling unit is configured to maintain the interior volume of the housing at the first predetermined temperature and the compartment at the second predetermined temperature.
Patent CA-3136884-A1 (CA)
Title: Container having box and sleeve with locking mechanism
Inventor: DAYIOGLU ONUR
IPC: B65D85/10
Filed: 2020-08-14
Abstract: A container (1) for consumer goods, the container comprises an outer sleeve (20) and inner box (10) disposed within the outer sleeve (20), and configured to slide within the outer sleeve (20) between: a first position, in which the interior of the inner box (10) cannot be accessed by a user; and a second position, in which the interior of the inner box (10) can be accessed by a user. The container (1) having a locking mechanism for preventing the inner box (10) from sliding from the first position to the second position, when the inner box (10) is in the first position in the outer sleeve (20).
Patent CA-3137710-A1 (CA)
Title: Non-hormonal treatment of hot flashes
Inventor: KNOBLER ROBERT L
IPC: A61K31/404
Filed: 2020-04-08
Abstract: The subject invention describes the use of dopamine agonists with affinity for the dopamine D2, D3, and D4 receptors (the D2 family) for treatment of hot flashes. Alpha-2- adrenergic agonists act synergistically to further reduce the frequency and severity of hot flashes and prolong the duration of dosing effectiveness. The combination of a D2 family dopamine agonist and alpha-2-adrenergic agonist, as well as additional molecules that can utilize the D2 receptor family pathway through formation of heterodimers, permits a multitude of molecules of varying efficacy for the treatment of hot flashes in either women or men. The subject invention expands the available non-hormonal options for treatment of hot flashes that are otherwise most disruptive to normal activities of daily living.
Patent CA-3138395-A1 (CA)
Title: Vehicle
Inventor: RODRIGUEZ WILLIAM B
IPC: B62D21/18
Filed: 2021-11-03
Abstract: A side-by-side vehicle is disclosed. The vehicle may include a rear, independent trailing arm suspension system and a drive train. The drive train may include an output from a power train coupled to a jack shaft to drive the vehicle. The jack shaft may be positioned entirely below the power train. A brake and sprocket may be positioned along the jack shaft. Additionally, the power train may be adjustably mounted to a frame of the vehicle.
Patent CA-3140773-A1 (CA)
Inventor: PENG XIANFENG
IPC: C07C49/713
Filed: 2019-05-23
Abstract: A feed composition comprising hexahydro-ß-acid component compounds shown in formula I, i.e. hexahydrocolupulone and/or hexahydroadlupulone, applications of the feed composition and the hexahydro-ß-acid component compounds, and a method for using the feed composition to improve animal production performance.
Patent CA-3140845-A1 (CA)
Inventor: KHILLAR SHIV PRASAD
IPC: G06F40/205
Filed: 2020-07-21
Abstract: La présente invention concerne des procédés et des systèmes de génération d'une requête de recherche conforme à un schéma de base de données d'après une entrée en langage naturel. Une entrée en langage naturel peut être reçue en provenance d'un dispositif informatique. L'entrée en langage naturel peut être associée à de multiples demandes de recherche adressées à une base de données. L'entrée en langage naturel peut être analysée pour donner une pluralité de segments. La pluralité de segments peut être, par exemple, un ou plusieurs mots d'une chaîne de texte. Au moins un identifiant pour la pluralité de segments peut être associé à une ou plusieurs valeurs de confiance. L'entrée en langage naturel peut être convertie en une requête de recherche unique d'après les valeurs de confiance et/ou un ensemble de règles. La requête de recherche unique peut être lancée par rapport à la base de données. La requête de recherche unique peut extraire du contenu plus efficacement que les multiples demandes de recherche.
Patent CA-3141512-A1 (CA)
Title: A laterally displaceable railway wagon
Inventor: ERIKSSON JAN
IPC: B61D47/00
Filed: 2019-05-29
Abstract: A railway wagon (1) comprising a load carrier (2), and front and rear bogies (3, 4), wherein each bogie comprises a platform (5, 6), which is rotatably mounted. The load carrier is releasably connected to, and laterally displaceable in relation to, the platforms. The load carrier has a front end and a rear end (7, 8) and is provided, at each end, with a connection portion (15, 16), and two support devices (30, 31), which are laterally spaced, and which support the load carrier in a position where it is laterally displaced in relation to the platform. The support devices are vertically operable between an idle position and a support position, in which the support devices abut against the ground. Further, the railway wagon comprises a displacement device for laterally displacing the load carrier. The displacement device comprises a reciprocating launch device (23), which is arranged to reciprocate laterally of the platform, a launch device connection mechanism, for releasably connecting the connection portion with the launch device, and a platform connection mechanism (25) for releasably connecting the connection portion with the platform.
Patent CA-3143076-A1 (CA)
Title: Low-pollution antidegradant compound and antidegradant composition and rubber composition comprising the same for tires
Inventor: GAO YANG
IPC: C08K3/04
Filed: 2019-12-23
Abstract: Antidegradant compound of Formula (I) and antidegradant composition comprising the same and rubber composition comprising the antidegradant compound or composition. The rubber composition has good resistance to appearance discoloration while maintaining the mechanical and anti-aging properties, thus, are suitable for making the entire tire or as part of the rubber matrix.
Patent CA-3145796-A1 (CA)
Inventor: NAIDU VENKATARAMANA
IPC: A61K9/14
Filed: 2020-07-09
Abstract: La présente invention concerne une composition orale stable pour le cyclophosphamide ou son sel pharmaceutiquement acceptable. Ladite composition pour cyclophosphamide peut se présenter sous la forme d'une poudre pour une solution orale, qui peut fournir une stabilité améliorée, une facilité de reconstitution et une meilleure palatabilité appropriées pour des patients pédiatriques. En outre, l'invention concerne un procédé de préparation de ladite poudre pour une solution orale de cyclophosphamide.
Patent CA-3145892-A1 (CA)
Inventor: JONIKAS MARTIN C
IPC: C12N1/12
Filed: 2020-07-30
Abstract: Described herein are chimeric polypeptides that include one or more Rubisco-binding motifs (RBMs) and a heterologous polypeptide. Additional aspects of the present disclosure provide genetically altered plants having a chimeric polypeptide including one or more Rubisco-binding motifs (RBMs) and a heterologous polypeptide. Further aspects of the present disclosure relate to genetically altered plants having a stabilized polypeptide including two or more RBMs and one or both of an algal Rubisco-binding membrane protein (RBMP) and a Rubisco small subunit (SSU) protein. Other aspects of the present disclosure relate to methods of making such chimeric polypeptides and plants, as well as cultivating these genetically altered plants.
Patent CA-3148897-A1 (CA)
Title: Effecteur terminal et appareil d'entrainement d'effecteur terminal
Inventor: KIM DANIEL H
IPC: F16C1/12
Filed: 2018-12-20
Abstract: Il est décrit un effecteur dextrémité pour un appareil chirurgical comprenant un boîtier ayant une paroi externe et une ouverture à lintérieur de celui-ci, et de première et deuxième parois opposées sétendant le long de côtés opposés à louverture, un premier actionneur couplé de façon pivotante à la première paroi du boîtier, un deuxième actionneur couplé de façon pivotante à la deuxième paroi du boîtier, et un couplage disposé à lintérieur de louverture du boîtier et entre au moins une partie des premier et deuxième actionneurs, le couplage comprenant des première et deuxième extrémités opposées, chaque extrémité étant couplée de façon pivotante à un actionneur différent parmi les premier et deuxième actionneurs. Pour faire fonctionner les actionneurs, il est décrit un mécanisme pour déplacer de manière contrôlée un fil à lintérieur dun élément tubulaire flexible, le fil comprenant des extrémités de fil opposées sétendant vers lextérieur dune extrémité proximale dun élément tubulaire flexible et une partie entre celles-ci reliée à un actionneur de leffecteur terminal, et il comprend un mécanisme dentraînement et un coupleur sétendant entre le mécanisme dentraînement et lextrémité de fil, le mouvement du couplage dans la direction de lextrémité de fil conduisant à un mouvement opposé de lextrémité de fil.
Patent CA-3148978-A1 (CA)
Inventor: LOMKOVA EKATERINA ALEKSANDROVNA
IPC: A61K47/26
Filed: 2020-08-21
Abstract: The present invention relates to the aqueous pharmaceutical compositions for the anti-PD-1 antibody prolgolimab and to the use of such pharmaceutical compositions as a medicinal agent for the treatment of PD-1-mediated diseases.
Patent CA-3149833-A1 (CA)
Title: Regenerating functions and phenotypes of connective tissue through npas2 suppression
Inventor: NISHIMURA ICHIRO
IPC: C12N15/113
Filed: 2020-09-04
Abstract: The present invention provides methods for improving or accelerating wound healing in a subject comprising administering to a wound of the subject in need thereof an agent that suppresses expression of a clock gene, wherein the clock gene is neuronal PAS domain protein 2 (Npas2). This invention also relates to methods for regenerating alveolar bone, regenerating connective tissue at a wound site, and for decreasing wound area size comprising administering to a bone loss site or a wound site, in particular, an open wound site, of a subject an agent that suppresses expression of Npas2.
Patent CA-3152953-A1 (CA)
Inventor: GRAZIADEI JOHN
IPC: E01F13/02
Filed: 2022-03-22
Abstract: At least one modular vehicular barrier includes an angle connector bracket, a first barrier arm, a second barrier arm, and a fastening mechanism. The first barrier arm is positioned in between a left plate and a right plate of the angled connector bracket as a proximal end of the first barrier arm is connected to the left and right plates. The second barrier arm is perimetrically positioned in between a front plate, a rear plate, the left plate, and the right plate of the angled connector bracket as a proximal end of the second barrier arm is removably mounted to the left and right plates through the fastening mechanism. The first barrier arm and the second barrier arm are positioned at an obtuse angle so that the modular vehicular barrier is able to lift and disable a motor vehicle, when the motor vehicle attempts to drive through.
Patent CA-3154291-A1 (CA)
Title: Materiau aerosolisable
Inventor: DAVIS MICHAEL FOSTER
IPC: A61K31/352
Filed: 2020-10-08
Abstract: L'invention concerne un matériau aérosolisable comprenant au moins un cannabinoïde et au moins un constituant de support, le matériau ayant une turbidité d'environ 10 UTN (unité de turbidité néphélométrique) ou moins.
Patent CA-3155967-A1 (CA)
Inventor: RUIZ SEBASTIEN
IPC: F03B3/10
Filed: 2020-10-29
Abstract: The invention concerns a method for starting a hydroelectric turbine (10) in a pumping mode, said turbine being provided with a runner (6) mechanically coupled to a shaft line (8) and a variable speed electric motor connected to a grid, a distributor (4) comprising guide vanes to control a flow of water to said runner, the method comprising: a) a step of operating the variable speed motor at least partly at fixed speed, said guide vanes being only partially opened, and of defining or calculating: - data of a plurality of hydraulic characteristics (C1, C2, Ci) of the turbine for an operation without cavitation; - data of an operation range of the electric motor, giving the speed of the motor as a function of its power; b) then a step of operating the turbine in a power control mode.
Patent CA-3156836-A1 (CA)
Inventor: ROSATI GIORGIO
IPC: A42B1/04
Filed: 2020-11-09
Abstract: A protective hood (1) for surgical use, apt to be worn, in sterile form, by an operator over an instrumented helmet, which hood (1) comprises: a front vision lens (20); an enveloping main body (10) fixed to the vision lens (20), configured to cover wholly the operator's head and neck and an upper part of the chest, which enveloping main body (10) comprises a front portion (11) and a rear portion (12) connected and made integral by means of two opposite side portions (13, 14), wherein the rear portion (12) has a pair of lateral strings (31, 32) arranged on opposite sides with respect to a sagittal plane of the operator and which extend, in use, laterally outside, which strings are grasped by the operator during wearing in order to ease unwinding the hood.