baber/WOPTO huggingface dataset:
Patent CA-2844855-A1 (CA)
Inventor: GE YU
IPC: A61P35/00
Filed: 2012-08-08
Abstract: (see formula I) The present invention provided a PIM kinase inhibitor - a compound with a general structural formula represented by Formula I. Also provided are isomers, diastereomers, enantiomers, tautomers, and pharmaceutically acceptable salts represented by Formula 1. E, J, Q, X, Y, Z and m in Formula I are defined in Claim 1. A PIM biochemical assay shows that the compounds (1-96) of the present invention can significant inhibit PIM-1 kinase activity. At 3 micromolar concentration, the compounds of the present invention can inhibit PIM-2 and PIM-3 activities by as much as 100%.  Therefore, the PIM kinase inhibitors of the present invention can be used to prepare drugs to treat PIM kinase mediated diseases such as cancers, autoimmune diseases, allergic reactions, or organ transplant rejection, thus have great clinical value. Also provided are preparation methods for the compounds represented by Formula I.
Patent CA-2845072-A1 (CA)
Inventor: WHITFIELD KENNETH H
IPC: A61B17/128
Filed: 2005-10-07
Abstract: An apparatus for application of surgical clips includes: a body and a handle.  The body supports a clip carrying channel having a distal window. A jaw assembly including first and second portions movable between spaced-apart and approximated positions. A  feed bar having a distal window advances a clip to the jaw assembly while the jaw portions are in the spaced apart position. A rack having ratchet teeth is connected to an actuator. A pawl engages the ratchet teeth, the pawl being biased in the handle wherein as the actuator is moved longitudinally, the ratchet teeth are passed over the pawl. The pawl prevents return of the actuator before full advancement of the actuator. A lock out bar is connected to the clip pusher.  The clip pusher moves distally each time a clip is released from the apparatus, and moves the lock out bar distally. When the lock out bar is in alignment with the distal window of the feed bar, the lock out bar is urged to a second position through the distal window by a spring to extend across the feed bar. The lock out bar in the second position prevents the actuator from moving proximally, thereby maintaining the pawl in engagement with the teeth of the rack, the pawl and rack preventing the actuator from moving longitudinally.
Patent CA-2845107-A1 (CA)
Title: Audio interface adapter device and audio signal receiving apparatus
Inventor: LI DONGSHENG
IPC: H04R3/00
Filed: 2012-12-28
Abstract: An audio interface adapter device and an audio signal receiving apparatus are provided. The audio interface adapter device comprises an audio interface having a pin 1, a pin 2, a pin 3 and a pin 4. The pin 1 and/or the pin 2 is used as an audio pin of the audio interface. One of the pin 3 and the pin 4 is used as a microphone pin, and the other one of the pin 3 and the pin 4 is used as a ground pin. The audio pin is connected with the pin 3 via a first unidirectional conductive element, and connected with the pin 4 via a second unidirectional conductive element. A  conductive direction of the first unidirectional conductive element is from the audio pin to the pin 3, and a conductive direction of the second unidirectional conductive element is from the audio pin to the pin 4.
Patent CA-2847502-A1 (CA)
Inventor: BOSMA ROB
IPC: B01L3/00
Filed: 2012-09-27
Abstract: The present invention relates to a sealing device for closing an introduction aperture, the sealing device comprising a fixed support (2) and a shutter (3) mounted movably in translation relative to the support between an extended position and a final retracted position, wherein the sealing device is in a final retracted configuration and wherein the shutter closes introduction aperture. The device includes locking means for preventing any movement of the shutter when it is in the final retracted position. The sealing device further comprises an intermediate retracted configuration, wherein the shutter is at least partly retracted. The sealing device also comprises motion guiding means (5, 7, 14) for guiding the movement of the shutter and designed so that the extension of the shutter is required to move the shutter from the intermediate retracted position to the final retracted position.
Patent CA-2848315-A1 (CA)
Inventor: TAKAICHI KAZUHIRO
IPC: H02K1/27
Filed: 2012-09-20
Abstract: L'invention porte sur un dispositif de fabrication pour un corps d'aimant pour un pôle inducteur, lequel dispositif amène un poinçon de moule supérieur en contact avec un corps d'aimant fixé sur une matrice de moule inférieur et applique une pression pour fracturer le corps d'aimant, au moins une ou plusieurs parties saillantes étant formées dans le poinçon de moule supérieur de façon symétrique par rapport à une position centrale dans la direction de la largeur du corps d'aimant.
Patent CA-2848451-A1 (CA)
Inventor: CHARLOT REGIS JP
IPC: G06F17/30
Filed: 2012-01-09
Abstract: La présente invention a trait à un système et à un processus permettant de repérer des documents électroniques ou autre contenu électronique avec des concepts mentionnés, contenus ou par ailleurs décrits dans ledit contenu. Une fois repéré, le contenu peut être recherché, indexé et récupéré afin de fournir ce contenu à un utilisateur final ou autre destinataire. Le système peut être configuré de manière à gérer un nombre considérable de fichiers d'actif et un grand nombre d'utilisateurs, d'automatisations des processus et d'applications d'accès simultanément. Le système peut repérer automatiquement le contenu et il peut également inclure une interface utilisateur permettant de confirmer et de mettre à jour ces repères ainsi que de créer manuellement de nouveaux repères ou des repères supplémentaires. Le contenu peut inclure des documents tels que des documents médicaux liés aux procédures, aux diagnostics, aux médicaments ou autres domaines. En variante, le contenu peut inclure des informations concernant divers prestataires de soins, afin de permettre à un utilisateur de situer un médecin répondant à un ou plusieurs critères souhaités.
Patent CA-2850726-A1 (CA)
Title: Systeme de recharge bidirectionnel pour vehicule electrique
Inventor: ZAGHIB KARIM
IPC: B60L11/18
Filed: 2014-04-29
Abstract: Un véhicule électrique comprenant un système de propulsion électrique à moteur central (204) et un système de gestion véhicule (201), dans lequel que le véhicule intègre un chargeur bidirectionnel (203) et une batterie LiFePo4 (202).
Patent CA-2854470-A1 (CA)
Inventor: SOMAL HARDEV S
IPC: H02P3/02
Filed: 2012-11-05
Abstract: Embodiments may disclose a safety system for controlling an operation of a machine operated by an operator wearing an article of luminescent clothing, the system including a luminescent sensor configured to emit ultraviolet light toward a target area, and configured to detect light emitted by the article of luminescent clothing; a motor configured to drive a component of the machine; and a controller configured to control the motor and the luminescent sensor, wherein if the luminescent sensor detects the light emitted by the article of luminescent clothing within the target area, the controller controls the motor to stop driving the component of the machine.
Patent CA-2857168-A1 (CA)
Title: Protein inhibitors to complement and vegf pathways and methods of use thereof
Inventor: HER JENG-HORNG
IPC: A61K38/17
Filed: 2012-11-30
Abstract: The invention provides bispecific fusion proteins that inhibit activation of complement pathway and vascular endothelial growth factor (VEGF) pathway and methods for using these fusion proteins.
Patent CA-2858472-A1 (CA)
Inventor: HALLUNDBAEK JORGEN
IPC: E21B47/08
Filed: 2012-12-20
Abstract: The present invention relates to an annular barrier (1) to be expanded in an annulus (2) between a well tubular structure and an inside wall (4) of a borehole (5) downhole, comprising a tubular part for mounting as part of the well tubular structure, said tubular part (6) having a longitudinal axis; an expandable sleeve (7) surrounding the tubular part and having an outer face (8), each end (9, 10) of the expandable sleeve being fastened to the tubular part by means of a connection part (12), where one of the connection parts is a sliding connection part sliding in relation to the tubular part when the expandable sleeve is expanded; an annular barrier space (13) between the tubular part and the expandable sleeve; an aperture (11) in the tubular part for letting fluid into the annular barrier space to expand the sleeve; and an activatable shut-off valve (14) having an open and a closed position and arranged in the aperture, wherein the annular barrier further comprises a detection device (20) for detecting when the expandable sleeve has been expanded into a contact position, and wherein the detection device is adapted to provide a signal to activate the shut-off valve to bring the shut-off valve from the open to the closed position when detecting that the expandable sleeve is in the contact position. Furthermore, the invention relates to a downhole system comprising a plurality of annular barriers according to the invention and to a method for expanding an annular barrier.
Patent CA-2860727-A1 (CA)
Inventor: DUDA GEORG
IPC: G01N33/50
Filed: 2013-02-04
Abstract: ipa105wo 32 Abstract The present invention relates to a method for diagnosis of delayed bone fracture healing, comprising determining the frequency of a subpopulation of CD8+ cells selected from a first group comprised of CD8+CD57+, CD8+CD28- and CD8+CD28-/CD57+, in a sample obtained from a subject. The present invention further relates to a system and a kit of parts for prediction and resulting options for preventing of delayed bone fracture healing.
Patent CA-2861392-A1 (CA)
Inventor: SOARES CHRISTOPHER J
IPC: A61K38/22
Filed: 2013-01-25
Abstract: The embodiments provide a modified calcitonin gene-related peptide antagonist including an N-terminal fragment of modified calcitonin gene-related peptide or related protein family member where at least two residues of the N-terminal fragment are cysteine (Cys) and at least one amino acid comprises a non-threonine substitution of a threonine (Thr) residue; a central core where the central core comprises an oc-helix; and a C-terminal fragment of modified calcitonin gene -related peptide or related protein family member comprising a C-terminal amide and where at least one amino acid of the C-terminal fragment is phenylalanine (Phe), proline (Pro), tyrosine (Tyr) or hydroxyproline (Hyp) or pharmaceutically acceptable salt thereof, as well as compositions, including pharmaceutical compositions, comprising a subject peptide. The embodiments further provide treatment methods, including methods of treating a migraine, the methods generally involving administering to an individual in need thereof an effective amount of a subject peptide or composition.
Patent CA-2863110-A1 (CA)
Title: 1,2- pyridazine, 1,6- pyridazine or pyrimidine - benzamide derivatives as gpbar1 modulators
Inventor: DEHMLOW HENRIETTA
IPC: A61K31/50
Filed: 2013-04-02
Abstract: This invention relates to novel 1,2-pyridazines, 1,6-pyridazines or pyrimidines of the formula I wherein B1 to B3 and R1 to R7 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and may therefore be useful as medicaments for the treatment of diseases such as type II diabetes.
Patent CA-2863583-A1 (CA)
Title: Actuator system and method
Inventor: KOPP JOHN
IPC: B64C13/00
Filed: 2012-02-09
Abstract: An actuator system comprising a shared link (121) arranged to pivot about a first axis (131) relative to a reference structure, a controlled element (125) arranged to pivot about a second axis (126) relative to the reference structure, a first member (146, 152) arranged to pivot about a third axis (134) relative to the shard link and a fourth axis (136) relative to the controlled member, a first actuator arranged to control a first variable distance (LI) between the third axis and fourth axis, a second member (147, 153) arranged to pivot about a fifth axis (133) relative to the shared link and a sixth axis (135) relative to the controlled element, a second actuator (141) arranged to control a second variable distance between the fifth axis and the sixth axis, the system configured such that a change in the first variable distance causes rotation of the controlled element about the second axis when the second variable distance is constant and vice versa.
Patent CA-2865340-A1 (CA)
Inventor: GOVARI ASSAF
IPC: A61M25/095
Filed: 2014-09-26
Abstract: An apparatus, including a bus having electrical power and data lines, and a plurality of location pads, which are positionable at different, respective locations with respect to a body cavity in which the object is located, and which are connected to the bus in series so as to receive electrical power and exchange data signals over the bus.                                        Each location pad includes multiple radiator coils and driving circuitry configured to select, responsively to the data signals, different respective driving frequencies for the coils and to generate, using the electrical power from the bus, driving signals to drive the coils to produce magnetic fields at the respective driving frequencies. The apparatus also includes a console, which is configured to receive and process sensor signals from a magnetic sensor fixed to the object, in response to the magnetic fields in the body cavity, in order to compute position coordinates of the object.
Patent CA-2865583-A1 (CA)
Title: Systeme et procede pour attribution de ressources temporelles pour la communication dispositif a dispositif superposee sur un reseau cellulaire
Inventor: LIU DEPING
IPC: H04W72/04
Filed: 2013-02-22
Abstract: La présente invention concerne un système pour faire fonctionner un contrôleur de communication et un équipement utilisateur dans un système de communication sans fil. Le contrôleur de communication est conçu pour attribuer un premier jeu de sous-trames à un groupe d'UE pour une liaison DMC, attribuer un second jeu de sous-trames à un UE particulier dans le groupe d'UE, transmettre un premier message, qui comprend des informations sur le premier jeu de sous-trames, au groupe d'UE, et transmettre un second message, qui comprend des informations sur le second jeu de sous-trames, à l'UE particulier. Le second jeu de sous-trames est un sous-jeu du premier jeu de sous-trames, et des informations sur le second jeu comprennent des sous-trames que l'UE particulier peut transmettre aux autres UE dans le groupe d'UE. Des sous-trames dans le premier jeu non dans le second jeu sont attribuées pour la réception par l'UE particulier.
Patent CA-2868267-A1 (CA)
Title: Antimicrobial alcohol foam compositions and methods of preparation
Inventor: COHEN MITCHELL JARED
IPC: A01N31/02
Filed: 2013-03-15
Abstract: A method for preparing an antimicrobial alcoholic foam composition by combining two or more pre-mix compositions. A first pre-mix composition is primarily alcoholic comprises an alcohol, an acidic component, and a waxy component. A second pre-mix composition is primarily aqueous comprises water and a carbonate. An antimicrobial alcoholic foam composition that does not require added air or aerosol propellant is also provided.
Patent CA-2870370-A1 (CA)
Title: Low latency centralized rtk system
Inventor: FENTON PATRICK C
IPC: G01S19/12
Filed: 2013-03-25
Abstract: A low-latency centralized RTK system utilizes an RTK server to perform matched updates using base station GNSS measurements from one or more base stations and GNSS measurements from one or more rovers, and the one or more rovers produce RTK solutions based on the results of the matched updates. The RTK server includes one or more processors that perform the matched updates and a transmitter that transmits at least the ambiguities to the rovers. The respective rovers, which have processing power that is sufficient to quickly calculate RTK baselines, utilize the received ambiguities, the base station GNSS measurements received from either the RTK server or the base stations, known base station positions and instantaneous GNSS measurements at the rovers to readily determine and update their RTK baselines and their precise positions.
Patent CA-2872611-A1 (CA)
Title: Systems and methods for placing a coapting member between valvular leaflets
Inventor: KHALIL VIVIAN
IPC: A61M25/01
Filed: 2013-05-16
Abstract: The present invention relates to devices and methods for improving the function of a defective heart valve, and particularly for reducing regurgitation through an atrioventricular heart valve - i.e., the mitral valve and the tricuspid valve. For a tricuspid repair, the device includes an anchor deployed in the tissue of the right ventricle, in an orifice opening to the right atrium, or anchored to the tricuspid valve. A flexible anchor rail connects to the anchor and a coaptation element on a catheter rides over the anchor rail. The catheter attaches to the proximal end of the coaptation element, and a locking mechanism fixes the position of the coaptation element relative to the anchor rail. Finally, there is a proximal anchoring feature to fix the proximal end of the coaptation catheter subcutaneously adjacent the subclavian vein. The coaptation element includes an inert covering and helps reduce regurgitation through contact with the valve leaflets.
Patent CA-2873111-A1 (CA)
Inventor: FRYE SASHA
IPC: A61K31/517
Filed: 2013-05-13
Abstract: Provided are methods and compositions for clinical treatment of advanced HER2 positive solid tumors cancer using combination therapies comprising bispecific anti-ErbB2/anti-ErbB3 antibodies.
Patent CA-2875506-A1 (CA)
Title: Berberine for improving gut microbiota population
Inventor: ZHAO LIPING
IPC: A23L33/00
Filed: 2013-06-04
Abstract: The use of berberine in the manufacture of a medicament for improving gut microbiota population is disclosed, wherein the improving the gut microbiota population is characterized by selectively increasing a first gut microbiota population in a first subject compared to a first gut microbiota population in a second subject without administration of berberine while simultaneously decreasing a second gut microbiota population in the first subject compared to a second gut microbiota population in the second subject without administration of berberine, wherein the first gut microbiota population comprises Allobaculum, Bacteroides, Blautia, Butyricicoccus, Dorea, Holdemania, Lawsonia, Parabacteroides, Phascolarctobacterium, Sedimentibacter, or a combination thereof, and wherein the second gut microbiota population comprises Anaeroplasma, Bifidobacterium, Butyrivibrio, Coprococcus, Fastidiosipila, Marvinbryantia, Oribacterium, Roseburia, Ruminococcus, TM7_genera_incertae_sedis, or a combination thereof.
Patent CA-2877150-A1 (CA)
Inventor: LEFEBVRE GUY
IPC: G01P1/02
Filed: 2015-01-07
Abstract: A gas turbine engine comprises a hot section module which includes at least one electric probe assembly surrounded by an immediate environment having a local ambient temperature. The at least one electric probe assembly includes an electric probe having a probe body, and a conduit surrounding at least a portion of the probe body. In operation, the conduit carries a fluid flowing at a temperature lower than the local ambient temperature. The at least portion of the probe body is embedded in the fluid inside the conduit. The fluid thermally insulates the probe body from the local ambient temperature of the immediate environment around the at least one electric probe assembly.
Patent CA-2879860-A1 (CA)
Inventor: REN RUIHUA
IPC: C12Q1/68
Filed: 2013-07-23
Abstract: A method is provided for determining the zygosity of an Rf4 gene in a corn plant. A method may include performing a first PCR assay, a second PCR assay, quantifying probes used in the first and second PCR assays, and comparing the quantified probes to determine zygosity.
Patent CA-2880600-A1 (CA)
Inventor: MALEKSAEEDI GHASRALDASHTI SEYEDJALAL
IPC: F03B13/08
Filed: 2015-04-30
Abstract: The subject matter of this invention is presenting a new method to control of energy the rivers in full scale by making of the necessary equipment and special small hydro turbines that without the need to making of usual hydro dams can be installed on the streams or rivers with high-discharge to generate the electricity. In this method columns, plates and special small turbines are stabled and stayed in top on many lines steel tension cables, in bottom on the riverbed. The plates collect the water flow and send them to the special turbine they can have a high efficient to convert so much amount of the energy of water flow to electricity.  This new usage method of rivers will be introduced by name of the Cable- Hydro dam and turbines or in brief CHdam & turbines.
Patent CA-2883521-A1 (CA)
Title: Information management systems and methods using a biological signature
Inventor: HOLMES ELIZABETH A
IPC: C12Q1/68
Filed: 2013-09-06
Abstract: Systems and methods are provided for generating a biological signature such as a genetic signature and using such signature of an individual. The biological signature may be used to verify the identity of the individual. A verified individual may be granted access to a secured location, item, and/or service. Biological signatures may also be used to search or aggregate records for an individual.
Patent CA-2884752-A1 (CA)
Inventor: TAMANAJA IVAN TORRES
IPC: G01V1/38
Filed: 2013-09-13
Abstract: A marine node for recording seismic waves underwater. The node (500) includes a main body (502) having a torus shape; a central body (504) provided inside a space (503) defined by the main body (502) and connected to the main body (502) through at least a link (506); a first thruster (508) provided in the main body (502) and configured to propel the main body (502) along a central axis (Z) of the main body (502); and a seismic sensor (570 or 572) configured to record the seismic waves underwater.
Patent CA-2885216-A1 (CA)
Inventor: KASPAR BRIAN
IPC: A61K38/17
Filed: 2013-09-17
Abstract: The invention relates to pharmaceutical compositions, kits, methods, and uses for the treatment of amyotrophic lateral sclerosis. In particular, the invention relates to pharmaceutical compositions, kits, methods, and uses for the treatment of amyotrophic lateral sclerosis by decreasing the expression of a cytoplasmic granule toxin in astrocytes of a patient, or by increasing the expression of MHC class I in motor neurons of the patient.
Patent CA-2885704-A1 (CA)
Inventor: ARNE LAWRENCE
IPC: G01D21/00
Filed: 2013-09-18
Abstract: Disclosed is a wireless wearable sensor apparatus. The wireless wearable sensor apparatus includes a sensor platform having a signal processing device with a computational engine to implement signal processing tasks. The sensor platform is configured to receive signals from at least one sensor coupled thereto. A wireless communication circuit is coupled to the sensor platform. The wireless communication circuit comprises a link master controller configured to communicate to a wireless device and transfer data. In one aspect, the link master controller is configured to control data transmission over a communication link established with to wireless device, comprising timing control and frequency control. The wireless wearable sensor may include a processor, a memory, and an accelerometer coupled to the sensor platform.