baber/WOPTO huggingface dataset:
Patent CA-2354148-C (CA)
Title: Aerosol formulations for buccal and pulmonary application
Inventor: MODI PANKAJ
IPC: A61P31/12
Filed: 1999-12-16
Granted: 2010-11-23
Abstract: A mixed micellar aerosol pharmaceutical formulation includes a micellar proteinic pharmaceutical agent, an alkali metal lauryl sulphate, at least three micelle forming compounds, a phenol and a propellant. The micelle forming compounds are selected from the group consisting of lecithin, hyaluronic acid, pharmaceutically acceptable salts of hyaluronic acid, glycolic acid, lactic acid, chamomile extract, cucumber extract, oleic acid, linoleic acid, linolenic acid, monoolein, monooleates, monolaurates, borage oil, evening of primrose oil, menthol, trihydroxy oxocholanyl glycine and pharmaceutically acceptable salts thereof, glycerin, polyglycerin, lysine, polylysine, triolein, polyoxyethylene ethers and analogues thereof, polidocanol alkyl ethers and analogues thereof, chenodeoxycholate and deoxycholate. The amount of each micelle forming compound is present in a concentration of from 1 to 20 wt/wt.% of the total formulation, and the total concentration of micelle forming compounds are less than 50 wt./wt.% of the formulation. The propellant, e.g., a fluorocarbon propellant, provides enhanced absorption of the pharmaceutical agent, particularly in the buccal cavity.
Patent CA-2354154-C (CA)
Inventor: PERAUS GISELA
IPC: A61K45/00
Filed: 1999-11-27
Granted: 2011-01-04
Abstract: The invention relates to a method for determining .gamma.-secretase activity, to individual components of the method and the application of the method. The invention provides a novel method for determining .gamma.-secretase activity and for detecting .gamma.-secretase; particular embodiments of the method relate to methods for identifying a .gamma.-secretase or a cDNA which codes for a .gamma.-secretase and methods for identifying substances which can inhibit the activity of a .gamma.-secretase. Substances of this type are particularly significant since they can be used, e.g. as pharmaceutical active agents, e.g. for treating Alzheimer's disease.
Patent CA-2355579-C (CA)
Inventor: ANDERSEN VILBOUR KIM
IPC: C11D3/386
Filed: 1999-12-20
Granted: 2011-11-22
Abstract: Cette invention se rapporte à des enzymes subtilases des sous-groupes I-S1 et I-S2 comportant un résidu d'acide aminé additionnel dans la position 100 de la région boucle de site actif (b) entre la position 95 et 103. Des variants de ces substilases possèdent des performances de lavage améliorées dans un détergent par rapport à leur enzyme parente.
Patent CA-2360990-C (CA)
Inventor: CHUANG HSU-CHEN
IPC: G01N33/18
Filed: 2001-11-01
Granted: 2004-06-22
Abstract: An apparatus for monitoring presence of hydrocarbon-based fluid is disclosed.  It includes a body and a sensing cable mounted on the body in a wave-like shape, thus forming a plurality of sensing sections for detecting a layer of hydrocarbon on water. When contacting hydrocarbon, each of the sensing sections generates a signal and the signals add up before transmission to a signal receiver through a signal line.
Patent CA-2372734-C (CA)
Title: Instrument for inserting graft fixation device
Inventor: BOWMAN STEVEN M
IPC: A61F2/00
Filed: 2002-02-22
Granted: 2010-02-16
Abstract: An instrument for inserting a graft fixation device. The fixation device is useful for affixing a tissue graft to a bone or other body surface. The graft fixation device comprises two implantation members connected by a connecting member. The fixation device can be combined with insertion members. The implantation members have longitudinal passageways therethrough. The instrument has a hammer handle slidably mounted to a slide rod. The slide rod is mounted at an angle to a mounting member. A mounting rod having an angulated distal end is mounted to the mounting member. Prongs extend longitudinally out from the angulated distal end. The longitudinal axis of the slide rod is parallel to the longitudinal axis of the angulated distal end. The prongs are optionally removably mounted in an end housing mounted to the angulated distal end.
Patent CA-2376313-C (CA)
Title: System capacity control
Inventor: KOWALSKI JOHN
IPC: H04B17/00
Filed: 1996-06-27
Granted: 2008-12-30
Abstract: An automatic power control (APC) system for a spread-spectrum communications system includes an automatic forward power control (AFPC) system, and an automatic reverse power control (ARPC) system. In the AFPC, each subscriber unit (SU) measures a forward signal-to-noise ratio of a respective forward channel information signal to generate a respective forward channel error signal which includes a measure of the uncorrelated noise in the channel and a measure of the error between the respective forward signal-to-noise ration and a pre determined signal-to-noise value. A control signal generated from the respective forward channel error signal is transmitted as part of a respective reverse channel information signal. A base unit includes AFPC receivers which receive respective reverse channel information signals and extract the forward channel error signals therefrom to adjust the power levels of the respective forward spread-spectrum signals. In the ARPC system, each base measures a reverse signal-to-noise ratio of each of the respective reverse channel information signals and generates a respective reverse channel error signal which includes a measure of the uncorrelated noise in the channel and a measure of the error between the respective reverse signal-to- noise ratio and a pre determined signal-to-noise value. The base unit transmits a control signal generated from the respective reverse channel error signal as a part of a respective forward channel information signal. Each SU includes an ARPC receiver which receives the forward channel information signal and extracts the respective reverse error signal to adjust the reverse transmit power level of the respective reverse spread-spectrum signal.
Patent CA-2378949-C (CA)
Inventor: SIEBOLD BERNHARD
IPC: A61M5/00
Filed: 2000-07-11
Granted: 2015-03-31
Abstract: Liquid growth hormone formulations are storage stable for more than six months at temperatures in the range 2-8 ~C by simply formulating growth hormones in phosphate buffer with no other additives at around physiological pH. By ensuring a pH of about 6.2 or greater, growth hormone crystallisation during storage at refrigeration temperatures or above is inhibited or reduced. Low concentrations of non-ionic surfactant can help to reduce aggregation of growth hormone arising as a result of physical forces encountered during automated transfer of bulk formulation into dosage containers. Mannitol is included in order to provide an isotonic formulation. Preservatives are included to reduce bacterial contamination and thereby permit multiple dosage units which can be stored at 2-8 ~C.
Patent CA-2381575-C (CA)
Inventor: MOITZHEIM JURGEN
IPC: F16L11/12
Filed: 2000-07-13
Granted: 2004-08-03
Abstract: The invention relates to a coolant tube (1) for motorcar engines that consis ts of a thermoplastic material. Said tube (1) is provided on at least one end ( 2) with at least one part of a catch or snap-in coupling (6) that was integrall y formed with the tube when the latter was produced.
Patent CA-2384524-C (CA)
Inventor: KANZLER HELMUT
IPC: A01D34/86
Filed: 2000-09-08
Granted: 2010-01-12
Abstract: La présente invention concerne un dispositif particulièrement approprié pour préparer/façonner divers aspects de terrains enneigés empruntés par des néviplanchistes et/ou des skieurs se divertissant. Ledit dispositif comprend un ensemble de bras ajustable (2) qui peut être fixé à une extrémité d'un véhicule adéquat et déployé pratiquement dans le sens orthogonal du mouvement dudit véhicule, ledit bras étant quasiment allongé et comprenant au moins deux sections (5, 6, 7) rattachées de manière articulée et au moins un dispositif de commande (11, 12, 13) destiné à modifier l'orientation d'au moins deux desdites sections (5, 6, 7) l'une par rapport à l'autre. Le dispositif de cette invention est également approprié au façonnage de levées de terrain ou d'aspects de la terre, du sol, du sable etc. ou à la coupe d'herbes ou de plantes et de broussailles similaires.
Patent CA-2389447-C (CA)
Inventor: LEWIS DAVID L
IPC: C22C38/14
Filed: 2002-06-06
Granted: 2008-03-25
Abstract: Thermal conductivity of glassware forming blank molds and blow molds of Ni--Resist ductile iron is selectively controlled by formation of compacted graphite in the mold microstructure during preparation of the melt and casting of the mold bodies.  Specifically, with a Type D5 Ni-Resist ductile iron according to ASTM-A439-84, compacted graphite is selectively formed in the cast microstructure of the mold body by reducing the magnesium and sulphur concentrations in the iron composition to the range of 0.01 to 0.04 wt %  magnesium and 0.00 to 0.01 wt % sulphur, and adding titanium to the iron composition in the range of 0.10 to 0.25 wt % titanium. Whereas formation of compacted graphite in the cast microstructure is normally considered to be undesirable for glassware forming molds, it has been found that formation of a small but appreciable amount of graphite provides the opportunity selectively to tailor the thermal conductivity characteristics of the mold body.
Patent CA-2390699-C (CA)
Title: Surveillance of the quality of service in a digital television link
Inventor: ABRAHAM DENIS
IPC: H04H20/00
Filed: 2000-11-08
Granted: 2004-05-04
Abstract: The quality of service in a digital television link (SME, LI, SMR) is surveyed cyclically by means of an analyzer (AM1 or AM2 or AM3) which analyzes the transport stream packets (TS) in order to determine a number of standardized analysis parameters which are complex to interpret. The invention minimizes the number of measurements of these parameters by selecting first and second analysis parameters in advance and periodically determining a first maximum for variations from the first selected parameters and the second maximum for variations from the second parameters selected in order to determine, respectively, a first parameter (SS) which is representative of the synchronization relative to the equipment in the link and at least one second parameter (TS; FD) which is representative of a degradation in a link.
Patent CA-2390901-C (CA)
Title: Xerographic paper and coating compositions therefor
Inventor: DRAPPEL STEPHAN V
IPC: D21H19/18
Filed: 2002-06-19
Granted: 2009-02-24
Abstract: A photopaper coating composition comprising a solvent containing up to about 40% by weight of polyester and wax and a process for making such coating composition. The composition having use as a coating on a substrate, the coated substrate being suitable for use in colour engines employing oil-less fusers.
Patent CA-2393140-C (CA)
Inventor: BROWN DAVID A
IPC: H04L12/56
Filed: 2000-11-30
Granted: 2012-08-28
Abstract: In a switch including a plurality of ports, an IP Multicast packet arriving on an ingress port a copy of the receiver packet is forwarded to each member of the IP Multicast group at wire-speed. The packet is bridged once to a given egress port and may be routed multiple times out of the egress port. If multiple subnets exist on an egress port, each subnet that requires a copy of the packet will receive the packet with its VLAN ID included in the packet.  The received IP Multicast packet for an IP Multicast group is stored in memory, a pointer to the location of the packet in memory is stored for each port to which a copy of the packet is to be forwarded. An IP Multicast forwarding entry is provided for the IP Multicast group. The forwarding entry includes a modification entry for each packet to be forwarded to the IP  Multicast group. A copy of the stored packet is modified dependent on the modification entry and forwarded in the next available port cycle for the port.
Patent CA-2394848-C (CA)
Title: 3-(4,5-dihydroisoxazole-5-yl)benzoylpyrazole
Inventor: BAUMANN ERNST
IPC: C07D409/14
Filed: 2000-12-19
Granted: 2010-04-27
Abstract: The invention relates to 3-(4,5-dihydroisoxazole-5-yl)benzoylpyrazole of the formula (I) and agriculturally useful salts thereof: (see formula I) wherein R1, R2 represent hydrogen, nitro, halogen, cyano, alkyl, halogenalkyl, alkoxy, halogenalkoxy, alkylthio, halogenalkylthio, alkylsulfinyl, halogenalkylsulfinyl, alkylsulfonyl or halogenalkylsulfonyl; R3 represents hydrogen, halogen or alkyl; R4 represents hydrogen or alkyl; R5, R6 represent hydrogen, halogen, cyano, nitro, alkyl, alkoxy, alkylthio, dialkylamino, phenyl or carbonyl, wherein the latter six groups can be substituted; R7 represents halogen, cyano, hydroxy, alkyl, halogenalkyl, alkoxy, halogenalkoxy, alkylthio, halogenalkylthio, alkylsulfinyl, halogenalkylsulfinyl, alkylsulfonyl, halogenalkylsulfonyl, amino, alkylamino, dialkylamino, dialkoxymethyl, hydroxyiminoalkyl, alkoxyiminoalkyl or optionally substituted carbonyl; R11 represents optionally substituted pyrazole that is bound in the 4 position and that carries a hydroxy group or a derivative thereof in the 5 position. The invention also relates to methods and intermediate products for preparing the 3-(4,5-dihydroisoxazole-5-yl)benzoylpyrazole, to agents containing them and the use of said derivatives or agents containing them for combating undesired plants.
Patent CA-2399118-C (CA)
Title: Method for operating extruder temperature controller with stable temperature reset
Inventor: EIVA SAULIUS TOMAS
IPC: B29C48/92
Filed: 2001-02-08
Granted: 2007-11-20
Abstract: The invention is a method for operating an extruder temperature controller.  The method can include sensing an actual screw speed for an extruder screw in an extruder barrel. The extruder barrel has at least one heat exchange means. The method can then involve indexing and storing a plurality of screw speeds. Each of the stored screw speeds corresponds to a temperature reset value. Comparing the actual screw speed with each of the stored screw speeds can then be performed. Selecting one of the stored screw speeds can then occur. The selected screw speed is a member of the plurality of stored screw speeds having a value most arithmetically equivalent to the actual screw speed. The step of selecting retrieves the temperature reset value corresponding to the selected, stored screw speed. Generating a control output driver signal to the heat exchange means can occur. The control output driver signal is responsive to the retrieved temperature reset value.  The invention includes delaying a control alarm for a predetermined time when generating a control output driver signal to the heat exchange means is at or near maximum capacity.
Patent CA-2401160-C (CA)
Title: Biologically active analogs of discodermolide
Inventor: GUNASEKERA SARATH P
IPC: A61P35/00
Filed: 2001-02-28
Granted: 2009-09-08
Abstract: The subject invention provides novel compositions of biologically active discodermolide compounds which can advantageously be used for immunomodulation and/or treating cancer. The compounds of the subject invention have utility for use in the treatment of cancer, as tubulin polymerizers and as microtubule stabilization agents The present invention also pertains to the identification of regions of the discodermolide molecule which are responsible for certain aspects of the bioactivity of discodermolide compounds.
Patent CA-2403069-C (CA)
Inventor: JAMES ROLLAND TRACY
IPC: G01R31/00
Filed: 2002-09-11
Granted: 2008-10-14
Abstract: A primary, normally open, DC monitoring circuit with a circuit continuity test device is disclosed which will also test one or more additional sensors connected to the circuit. The sensing of lack of continuity or of a fault condition detected by an additional sensor governs the status of a single indicator, generally a warning light.
Patent CA-2403439-C (CA)
Inventor: ST DENIS PERRY LUCIEN
IPC: E21B43/12
Filed: 2002-09-16
Granted: 2003-11-11
Abstract: A method of producing liquid from a well. A first step involves installing a tubing string in a well by securing a lower end of the tubing string via a telescopic connector to a pump tubing anchor positioned down the well. The telescopic connector allows a predetermined axial reciprocating pumping stroke of the tubing string relative to the pump tubing anchor. A second step involves positioning an hydraulic pump jack that has a reciprocating hollow piston rod at the top of the well. A third step involves securing an upper end of the tubing string within the hollow piston rod of the hydraulic pump jack. The reciprocating movement of the hollow piston rod serves to reciprocally move the tubing string through the reciprocating pumping stroke.
Patent CA-2406234-C (CA)
Inventor: SEIDEL EIKO
IPC: H04L1/00
Filed: 2001-02-21
Granted: 2005-06-28
Abstract: A hybrid ARQ retransmission method in a communication system, wherein data packets being encoded with a forward error correction (FEC) technique prior to transmission, are retransmitted based on an automatic repeat request and subsequently soft-combined with previously received erroneous data packets either on a symbol-by-symbol or a bit-by-bit basis. The symbols of said erroneous data packets are modulated by employing a predetermined first signal constellation. The symbols of the retransmitted data packets are modulated by employing at least a predetermined second signal constellation. Each symbol bit has a mean bit reliability defined by the individual bit reliabilities over all symbols of the predetermined signal constellation. According to the invention, the predetermined first and the at least second signal constellation are selected such that the combined mean bit reliabilities for the respective bits of all transmissions are averaged out.
Patent CA-2412317-C (CA)
Inventor: FISCHER TIMOTHY J
IPC: G01N33/92
Filed: 2001-06-08
Granted: 2016-03-22
Abstract: A method for diagnosing a condition of a patient involves the steps of (a) adding one or more reagents to a test sample from a patient, the test samples comprising at least part of a blood sample from the patient, in order to cause formation of a complex comprising at least one acute phase protein at at least one human lipoprotein, while causing substantially no fiber polymerization;  (b) measuring the formation of the complex over time so as to derive a time-dependent measurement profile, and (c) determining a slope and/or total change in the time-dependent measurement profile, so as to diagnose a condition of the patient. A greater formation of the complex is correlated to increased probability of death of the patient.
Patent CA-2417081-C (CA)
Title: Derives benzimidazolone n,n'-disubstitues presentant une affinite pour les recepteurs de la serotonine et de la dopamine
Inventor: GIRALDO ETTORE
IPC: A61K31/454
Filed: 2001-09-08
Granted: 2008-08-05
Abstract: L'invention concerne des dérivés benzimidazolone N,N'disubstitués, pharmacologiquement actifs, de formule générale (I) dans laquelle R?1¿, R?2¿, R?3¿, et A sont définis dans les spécifications et dans les revendications, leurs sels, acceptable sur le plan pharmaceutique, ainsi que leur préparation et leur utilisation à des fins thérapeutiques.
Patent CA-2419517-C (CA)
Title: Wide slit nozzle and coating method by wide slit nozzle
Inventor: NAKAMURA KAZUHIKO
IPC: B05B1/02
Filed: 2003-02-21
Granted: 2009-10-13
Abstract: A wide slit nozzle having a slit as a discharge opening for a coating material is provided. The slit has a first thickness at a lateral center part and a second thickness at opposite lateral end parts. The second thickness of the lateral end part is sot smaller than the first thickness at the lateral center part. The first thickness of the lateral center part is fined. The second, thickness of the lateral end part changes linearly from opposite lateral ends of the lateral center part to the opposite lateral ends of the slit. For example, the slit has dimensions: x=15mm, y=14mm, .alphaØ3mm and .beta.=0.6mm. Consequently, an entire length or an entire width of the slit 2 is 15+14 × 2=43mm. However, the coating material is discharged from the slit while applied with pressure, so that the coating material is coated while expanded wider than the width of the slit. The coating material is discharged at 7 liter per minute, and a coating width of the first example is 100mm, for example. A thickness increase of the overlapped part is +25% every when a width, or an overlapped margin z of the overlapped part is 10mm or 20mm.
Patent CA-2420119-C (CA)
Title: Procede et dispositif permettant de tester le fonctionnement de cartes de circuits imprimes
Inventor: STENGEL JURGEN
IPC: G01R31/28
Filed: 2001-08-01
Granted: 2009-12-22
Abstract: Procédé permettant de tester le fonctionnement de cartes de circuits imprimés, qui consiste à appliquer directement sur au moins une face d'une carte de circuits imprimés (1) une couche souple (2) ne laissant initialement pas passer le courant de manière à établir le contact, ladite couche étant connectée de manière fonctionnelle à un conducteur de courant (3), puis à mettre ladite couche (2) sous tension. Un passage de courant est alors partiellement créé vers les sites de contact qui délimitent une piste conductrice (5) à tester. Le flux de courant dans la piste conductrice (5) est ensuite mesuré par l'intermédiaire du conducteur de courant (3).
Patent CA-2421910-C (CA)
Title: Xanthine phosphodiesterase v inhibitors
Inventor: BOYLE CRAIG D
IPC: A61P3/10
Filed: 2001-09-17
Granted: 2007-07-10
Abstract: A xanthine phosphodiesterase V inhibitor having the formula (I), (see formula I) where R4 is a C3-15 cycloalkyl group, with or without one or more substituents, C3-15 cycloalkenyl group, with or without one or more substituents, or a heterocycloalkyl group of 3 to 15 members, with or without one or more substituents; useful for treating male (erectile) and female sexual dysfunction and other physiological disorders. For example, a representative compound of the invention is formula (II).     (see formula II)
Patent CA-2423335-C (CA)
Inventor: PACE GARY
IPC: A61K9/14
Filed: 2001-04-20
Granted: 2011-03-01
Abstract: Cette invention se rapporte à un nouveau procédé de séchage par atomisation qui sert à préparer des compositions pharmaceutiques contenant de petites particules de fénofibrate stabilisé par phospholipides. Cette invention concerne également des compositions pulvérulentes séchées par atomisation, préparées selon ledit procédé, et des formes posologiques de fénofibrate (capsules, comprimés, poudres, granulés et dispersions) préparées à partir de ces compositions pulvérulentes. Ces compositions pulvérulentes et ces formes posologiques sont utiles dans le traitement de la dyslipidémie et de la dyslipoprotéinémie et elles ont l'avantage de réduire la variabilité in vivo de la biodisponibilité des espèces actives de fénofibrate chez des patients nourris et à jeun, lorsqu'elles sont administrées par voie buccale.
Patent CA-2429650-C (CA)
Title: Oral pharmaceutical compositions containing cyclodextrins as taste masking agent
Inventor: STROPPOLO FEDERICO
IPC: A61K9/00
Filed: 2001-11-23
Granted: 2010-09-07
Abstract: The application discloses oral pharmaceutical compositions which are tasted in the mouth during administration. Fast-dissolving tablets, chewable tablets and effervescent dispersions are exemplified. To mask the taste of unpleasant-tasting active ingredients, it has been found that blending with cyclodextrin without the conventional complex formation is effective. Consequently more economical modes of manufacture such as simple granulation and dry blending can be used.
Patent CA-2433067-C (CA)
Title: An improved method for preparation of cefuroxime axetil
Inventor: KANSAL VINOD KUMAR
IPC: A61P31/04
Filed: 2001-07-25
Granted: 2010-04-27
Abstract: An improved method for synthesis of cefuroxime axetil of formula (I) in high purity substantially free of the corresponding 2-cephem(.DELTA.2)-ester of formula (II) and other impurities. The compound produced is valuable as a prodrug ester of the corresponding cephalosporin- 4-carboxylic acid derivative i. e. cefuroxime, particularly suitable for oral administration in various animal species and in man for treatment of infections caused by gram-positive and gram-negative bacteria.