baber/WOPTO huggingface dataset:
Patent DE-69223205-T2 (DE)
Inventor: EFFLAND RICHARD CHARLES
IPC: A61P25/18
Filed: 1992-09-21
Granted: 1998-05-14
Abstract: This invention relates to substituted pyridinylamino-1H-indoles, 1H-indazoles, 2H-indazoles, benzoÄbÜthiophenes and 1,2-benzisothiazoles of the formula <CHEM>  wherein     Q is S, N or NR<6>;     Y is CH, N or NR<6>; R<5> is hydrogen, loweralkyl, loweralkynyl, loweralkenyl, arylloweralkyl, loweralkoxycarbonylaminoloweralkylcarbonyl, arylloweralkoxycarbonyl-aminoloweralkylcarbonyl, aminoloweralkylcarbonyl, loweralkoxycarbonyl or acyl;     R<6> is hydrogen or loweralkyl;     R<7> is hydrogen or loweralkyl;     X is hydrogen, loweralkyl, halogen; and n is 0 or 1; or a pharmaceutically acceptable acid addition salt thereof. The compounds of this invention are useful in the treatment of memory dysfunctions characterized by a cholinergic deficit such as the type associated with Alzheimer's disease and other memory disorders. Compounds of this invention also have utility as modulators of neurotransmitter function such as noradrenergic and serotonergic and as such are useful for treatment of depression and personality disorders such as obesessive compulsive disorders. Additionally, compounds of this invention are useful as topical antiinflammatory agents for the treatment of various dermatoses.
Patent DE-69227583-T2 (DE)
Inventor: MEHTA NARIMAN
IPC: A61P25/00
Filed: 1992-04-22
Granted: 1999-04-01
Abstract: A method for the treatment of depression in a human being, the method comprising administering to the human being an antidepressant effective amount of a compound of the following formula   <IMAGE>   or a pharmaceutically acceptable salt thereof, wherein R and R1 are independently hydrogen or fluorine.
Patent DE-69229200-T2 (DE)
Inventor: BEST JOHN STEWART
IPC: G11B20/12
Filed: 1992-06-25
Granted: 1999-12-09
Abstract: A data recording disk file is provided with a fixed block architecture sector format that eliminates the ID region. The servo region contains sector identification information in the form of a start-of-track indicating mark recorded in a selected sector of each track and a start-of-sector indicating mark recorded in each sector. A full track number identifier is encoded in the position field within the servo region of each sector. A look-up table is built at format time to map bad sectors out of the disk file. The table contains entries for each cluster of contiguous bad sectors, and is searched at runtime to provide conversion of logical sector location identifiers to physical sector location identifiers.
Patent DE-69229732-T2 (DE)
Inventor: ROLCHIGO PHILIP
IPC: B01D63/16
Filed: 1992-05-28
Granted: 1999-12-02
Abstract: A rotary filtration system comprising a device having a fluid filtration gap between a filter and a rotating member (e.g., a disc), a filter pack for use in the rotary filtration device, and a cartridge formed by structurally connecting (and optionally fluidly connecting) two or more of the filter packs is disclosed. In the filter pack, the filter lies adjacent a permeate collection member, which also desirably can support the filter. The permeate collection member has one or more passageways for collecting the permeate that flows through the filter and is connected to a permeate collection header in the device. The filter pack and device are designed so that the filter pack may be easily inserted into and removed from the device, preferably by moving the filter pack in a direction generally perpendicular to the longitudinal axis of the shaft that rotates the rotating member. Desirably the rotating member and/or filter has one or more spiral grooves in fluid communication with fluid in the gap. Several rotating members and filter packs may be interleaved to increase filtration device capacity and make more efficient use of equipment space. In such a device, the rotating members can be mounted on a common shaft for rotation in unison and can have spiral grooves on both major faces of each rotating member.
Patent DE-69311893-T2 (DE)
Inventor: NORRIS FANNY
IPC: C07H21/04
Filed: 1993-01-07
Granted: 1998-02-05
Abstract: Variant of human Kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI), the variant comprising the following amino acid sequence   <IMAGE>    <IMAGE>    <IMAGE>    <IMAGE>naturally occurring amino acid residue except Cys, each Xaa at positions 2-5 is independently a naturally occurring amino acid residue except Cys or is absent, each Xaa at positions 14, 16, 18, 19, 20, 21, 22, 23, 37, 42, 43, 44, and 49 independently a naturally occurring amino acid except Cys, each Xaa at positions 61, 62, 63, and 64 is independently a naturally occurring amino acid except Cys or is absent, and Xaa at position 65 is OH or a naturally occurring amino acid except Cys, with the proviso that at least one of the amino acid residues designated Xaa is different from the amino acid residue of the native sequence.
Patent DE-69312512-T2 (DE)
Inventor: ROBIN JEAN-PIERRE
IPC: A61P35/00
Filed: 1993-12-20
Granted: 1998-03-05
Abstract: PCT No. PCT/FR93/01270 Sec. 371 Date Jun. 21, 1995 Sec. 102(e) Date Jun. 21, 1995 PCT Filed Dec. 20, 1993 PCT Pub. No. WO94/14829 PCT Pub. Date Jul. 7, 1994Compound of the formula (I) in which R' is a hydrogen atom or a radical R and R is an acyl residue. The invention also concerns the use of said compounds in the treatment of cancer and pharmaceutical compositions comprising said compounds.    <IMAGE>  I
Patent DE-69312820-T2 (DE)
Inventor: MARTIN TREVOR NEIL
IPC: A61M15/00
Filed: 1993-07-12
Granted: 1997-11-27
Abstract: Capsules (22) containing powder to be inhaled are received in a storage chamber (10) within a tubular body (3) of a dispensing apparatus (1). The chamber (10) has a cylindrical portion along which capsules are fed to a dispensing station (23) by a feed mechanism (19) having feed members (13,14). An actuating sleeve (4) overlays the body and is connected to the feed members which are moved into and out of the chamber by cam action. An end cap (15) slidable on the body has a gripping means (33) for gripping a forward portion (31) of a capsule to enable the capsule to be opened at the dispensing station by pulling apart portions of the capsule. The apparatus allows capsules to be opened for inhalation of the contents and for the spent capsules to be ejected by movement of a single sleeve actuator relative to a body. <IMAGE>
Patent DE-69319813-T2 (DE)
Inventor: IRWIN RICHARD NEIL
IPC: A01N43/30
Filed: 1993-09-08
Granted: 1998-11-26
Abstract: A louse or tick repellent composition comprising   i   at least 0.5 wt% of a compound of general formula I, ii   aqueous alcohol and iii   an alkoxylated alcohol or fatty acid nonionic emulsifier.
Patent DE-69325190-T2 (DE)
Inventor: WITT KLAUS LEONHARD
IPC: F15B21/044
Filed: 1993-01-19
Granted: 1999-10-28
Abstract: Method and device for detecting undissolved gas in a hydraulic control system of the type containing a hydraulic-medium-pressure pump and a feed reservoir, based upon checking the compressibility of the medium and deducting the amount of undissolved gas from the thus obtained information by taking into account that an increase of the amount of undissolved gas in the medium results in a decrease of the compressibility of this medium. <IMAGE>
Patent DE-69328941-T2 (DE)
Inventor: VAN DER LELY CORNELIS
IPC: A01K1/12
Filed: 1993-01-15
Granted: 2001-02-01
Abstract: An implement for milking animals comprises a milking machine with an arm (66) adapted to carry a number of teat cups (6), This arm (66) is rotatable about an upwardly directed axis relative to a holder (68), which holder (68) is in a fixed position in the implement. The teat cups (6) can be connected to the teats of the animal by hand and can be uncoupled automatically, without human labour, when the milk flow from the relevant udder quarters has stopped or has fallen below to a predetermined value.
Patent DE-69331994-T2 (DE)
Inventor: CHEN JANE-JANE
IPC: A61K38/00
Filed: 1993-08-27
Granted: 2003-02-20
Abstract: The cDNA which encodes heme-regulated eIF-2 alpha  kinase (HRI) has been cloned from a lambda Zap II cDNA library of rabbit reticulocytes. The rabbit HRI cDNA is highly homologous to human HRI and hybridizes to the human HRI DNA under moderately stringent conditions. The rabbit HRI cDNA contains 2729 amino acids. In vitro translation of HRI mRNA transcribed from HRI cDNA yields a 90 kDa polypeptide with eIF-2 alpha  kinase activity. Since HRI is a potent inhibitor of protein synthesis, it is anti-proliferative in nature. In addition, the unusually high degree of homology of HRI to three protein kinases involved in the regulation of cell division suggests that HRI plays a direct role in the regulation of cell division. Since regulation of protein synthesis is vital for cell growth and differentiation, the cDNA can be inserted into cells to manipulate proliferation and differentiation, especially of cells that are proliferating in an uncontrolled manner or characterized by arrested differentiation, such as some of the types of cancers. Deletion mutants of HRI cDNA can be constructed that are insensitive to regulation by heme, which should be more effective than native HRI in its anti-viral and anti-proliferative action.
Patent DE-69333436-T2 (DE)
Inventor: BALDWIN JOHN LEWIS EDWIN
IPC: G09G3/34
Filed: 1993-10-14
Granted: 2005-01-13
Abstract: A display device includes a deformable mirror device wherein grey scales are displayed using a time division modulation process in which the times or sub-frame periods for which each mirror within the deformable mirror array is switched on. The device includes a selection means for ordering selected sub-frame periods or divided sub-frame periods such that the light directed from each mirror is substantially temporally balanced during each frame period of the display device and/or between consecutive frame periods.
Patent DE-69401436-T2 (DE)
Inventor: CORBIN DAVID
IPC: A01N63/10
Filed: 1994-06-24
Granted: 1997-06-26
Abstract: 3-Hydroxysteroid oxidase controls insects, particularly lepidopterans and boll weevil. Genes encoding for this enzyme may be cloned into vectors for transformation of plant-colonizing microorganisms or plants, thereby providing a method of controlling insect infestation.
Patent DE-69401798-T2 (DE)
Inventor: VEDAGE GAMINI ANANDA
IPC: C07C209/72
Filed: 1994-09-21
Granted: 1997-06-05
Abstract: This invention relates to an improved process for the preparation of methylcyclohexane diamine wherein meta-toluenediamine is contacted with hydrogen in the presence of a hydrogenation catalyst. The improvement resides in utilizing a hydrogenation catalyst comprising rhodium carried on a support and carrying out the hydrogenation in the presence of a C3-C10 secondary alcohol as a solvent. With the use of rhodium carried on a support as a catalyst, coupled with the use of the secondary alcohol solvent, one obtains high yields with excellent catalyst life.
Patent DE-69406891-T2 (DE)
Inventor: DELATTE DANIEL
IPC: F25D25/00
Filed: 1994-10-03
Granted: 1998-03-12
Abstract: The cryobiological container comprises a double-casing reservoir structure (1) including an inner casing (2) having a cylindrical side wall (4) and a bottom wall (5) and forming an internal volume accessible via an upper opening (6) of the same diameter of the cylindrical wall (4), the bottom wall (5) comprising a central bearing (7) intended to receive a pivot (8) integral with the bottom (9) by a rotating storage tank (10) capable of being received in the internal casing (4) and having a cylindrical side wall (11) of diameter slightly less than that of the side wall (4) of the inner casing (2) and provided, at its periphery, with a plurality of guide and centring rollers (15) cooperating with the side wall (4) of the inner casing (2). The access opening (6) can advantageously be closed by a plug carried by a cover structure mounted so as to pivot on the reservoir structure (1). <IMAGE>
Patent DE-69407619-T2 (DE)
Inventor: HANSEN EJNER BJOERN
IPC: A47J37/12
Filed: 1994-11-15
Granted: 1998-07-16
Abstract: PCT No. PCT/DK94/00431 Sec. 371 Date Jul. 15, 1996 Sec. 102(e) Date Jul. 15, 1996 PCT Filed Nov. 15, 1994 PCT Pub. No. WO95/13734 PCT Pub. Date May 26, 1995An apparatus (1) for use in heat treatment of for example French fried potatoes (10). This process takes place in a treatment chamber (3) where the product is exposed to intensive heat radiation from a number of quartz tubes (14) while they constantly are turned by means of a rotating driving wheel (15) with a number of carriers (16) placed along the periphery. Humidity, smoke and smell separated from the product during this process are sucked off by means of a ventilator (17) which leads the polluted air through a filter device (4) via a convector (5) between the treatment chamber (3) and the filter device (4). The whole arrangement is built up into a cabinet (2) which on the top and at the bottom is provided with ventilation openings (26, 27) through which secondary air is flowing for cooling the polluted air flowing through the convector (5). Thereby a heat exchange effect is obtained for reducing the sucked off temperature to an acceptable level before the air reaches the filter device (4). The apparatus has a construction which is compact and environmentally compatible and suitable for preparing for example pre-fried potato pieces into ready French fried potatoes with very low contents of fat.
Patent DE-69409542-T2 (DE)
Inventor: MOLLARD THIERRY
IPC: B24C5/04
Filed: 1994-11-25
Granted: 1998-10-29
Abstract: Surface treatment nozzle for projecting solid particles carried along in a pressurized gas stream. Said nozzle comprises a channel having, in the direction of flow of the solid particles, firstly a converging section (6), then a diverging section (7) which opens from the nozzle as an outlet slot (4) and whose cross section is flattened parallel to said outlet slot, at least in the vicinity thereof. The channel cross section varies gradually along its entire length; the converging section (6) comprises an upstream end (5) flattened parallel to the outlet slot, the diverging section having two lateral portions of enlarged cross section (41).
Patent DE-69422835-T2 (DE)
Inventor: WALBERG DAVID
IPC: F16D9/02
Filed: 1994-06-01
Granted: 2000-07-06
Abstract: A device (110) for protecting a clutch (C) against overheating from externally caused problems such as rapid cycling is disclosed including a heat conductive plug (120) sealed in an escape port (116) of a fitting (112) by fuse material (124) such as lead. The fitting (112) is threadably, sealably received in a bore (104) formed in the friction interface disc (12) of the clutch (C). The bore (104) is in fluid communication with the cylinder (30) of the clutch (10) which slideably mounts a piston (10) connected to the friction interface disc (12). Fluid pressure introduced into the cylinder (30) by conventional conduits (42) moves the piston (10) therein against the bias of a spring (56) when fluid flow from the cylinder (30) through the bore (104) is blocked by the overheating protection device (110). When heat resulting from clutch temperatures exceeding normal operating temperatures and conducted to the fitting (112) and the device (110) is sufficient to melt the fuse material (124), the plug (120) is ejected from the escape port (116) by the fluid pressure communicated from the cylinder (30) to the bore (104). The fluid pressure of the cylinder (30) will be insufficient to move the piston (10) against the bias of the spring (56) when the escape port (116) is not sealed by the plug (120) and fuse material (124).
Patent DE-69423234-T2 (DE)
Inventor: SCHULTZ E
IPC: C08G59/40
Filed: 1994-10-12
Granted: 2000-08-10
Abstract: In summary, the invention is related to the discovery of a class of compounds which inhibits the reaction of a polyepoxide with a curing agent at low temperatures. An epoxy resin composition contains a) a polyepoxide; b) an amine or amide curing agent for the polyepoxide; c) at least about 15 meq (per equivalent of polyepoxide) of a catalyst for the reaction of the polyepoxide with the curing agent; and d) a cure inhibitor selected such that: (1) at about 171  DEG C the composition has a gel time that is at least about 50 percent longer than a similar composition without the inhibitor, and (2) at about 175  DEG C and higher the composition cures in no more than about 50 minutes. The composition can cure rapidly with high crosslink density because it has a high catalyst loading, but the inhibitor lengthens the gel time to permit laminating and other processing.
Patent DE-69428147-T2 (DE)
Inventor: DEAN WILLIAM D
IPC: C07D333/34
Filed: 1994-02-08
Granted: 2002-03-21
Abstract: Carbonic anhydrase inhibitors, useful in the control of ocular hypertension, and having the formula: <CHEM> wherein: R1 and R2 are both chosen from H or C1-4 alkyl; R3 = C1-6 alkyl or CH2(CH2)nOR4 where R4=CH3 or (CH2)nCH3 and n = 1-4; or (CH2)nAr where Ar = unsubstituted phenyl, 3-methoxyphenyl, or 4-methoxyphenyl and n = 1 or 2. are prepared by displacing the C(2)-chloro of 3-acetyl- 2,5-dichlorothiophene with benzyl mercaptide to form the thioether of structure, which is then converted to 3-acetyl-5-chloro-2-thiophenesulfonamide by reaction with chlorine to form 3-acetyl-5-chloro-2-thiophenesulfenyl chloride, followed by reaction with ammonia to form 3-acetyl-5-chloro-2-thiophenesulfenamide, and finally oxidation. Bromination provides 3-bromoacetyl-5-chloro- 2-thiophenesulfonamide which is converted to (S)-3,4- dihydro-6-chloro-4-hydroxy-2H-thieno[3,2-e]-1,2-thiazine-1,1-dioxide by reduction with (+)- beta -chlorodisopinocampheylborane followed by treatment with aqueous base. Alkylation at N(2) provides the (S)-3,4-dihydro-6-chloro-4-hydroxy-2-substituted-2H-thieno[3,2-e]-1,2- thiazine-1, 1-dioxide. Formation of the C(6) anion is accomplished by halogen-metal exchange, and the anion is reacted with sulfur dioxide to form a lithium sulfinate, which upon reaction with hydroxylamine-O-sulfonic acid provides the (S)-3,4-dihydro-4-hydroxy-2-substituted-2H-thieno[3,2-e]-1,2-thiazine- 6-sulfonamide-1, 1-dioxide. Protection of the C(6)-sulfonamide functionality, followed by activation of the C(4)-hydroxyl and displacement with an appropriate amine provides the (R)-3,4-dihydro-4-alkylamino-2-substituted-2H-thieno[3,2-e]-1,2-thiazi ne-6-sulfonamide-1,1-dioxide.
Patent DE-69500487-T2 (DE)
Inventor: KOULBANIS CONSTANTIN
IPC: A61K8/68
Filed: 1995-08-04
Granted: 1997-12-04
Abstract: Cosmetic and/or dermatological compsn. contains a maize flour extract encapsulated in "spherules" esp. liposomes.
Patent DE-69504492-T2 (DE)
Inventor: BOUAN BRUNO
IPC: H04R5/033
Filed: 1995-03-10
Granted: 1999-04-29
Abstract: A headset comprising two speakers (9, 10) each mounted in a housing and connected to a lead, the housings being linked by an arcuate headband. The housings and the headband are made of a generally U-shaped single piece of resilient moulded plastic (1) with a recess at each end, of which the open side faces a transverse plane, the lead being protected by a flexible tube formed by spirally winding a metal strip of which one end is secured to the single plastic piece (1). A method for making the headset is also disclosed.
Patent DE-69519654-T2 (DE)
Inventor: FUJIWARA TSUTOMU
IPC: C12N15/09
Filed: 1995-09-05
Granted: 2001-05-17
Abstract: The present invention provides a hTFIIIA gene containing a base sequence coding for the amino acid sequence shown under SEQ ID NO:1, in particular a hTFIIIA gene containing the base sequence shown under SEQ ID NO:2. The gene can express a corresponding hTFIIIA protein. The gene and protein serve as transcription regulating factors and are useful in the diagnosis or identification of hereditary diseases such as cancer or other diseases resulting from abnormal transcriptional control and, further, in analyzing the mechanisms of action thereof.
Patent DE-69524118-T2 (DE)
Inventor: NIKANDER RISTO KALEVI
IPC: C03B27/044
Filed: 1995-10-24
Granted: 2002-07-18
Abstract: PCT No. PCT/FI95/00585 Sec. 371 Date Jul. 1, 1997 Sec. 102(e) Date Jul. 1, 1997 PCT Filed Oct. 24, 1995 PCT Pub. No. WO96/13465 PCT Pub. Date May 9, 1996A method and apparatus for adjusting a quench head for glass tempering is provided. The quench head comprises at two nozzle blocks, each one of the nozzle blocks comprising at least one nozzle for directing the flow of a substance in gaseous phase to impinge onto the surface of the glass at certain areas. The nozzle blocks are supported on a frame to form at least one row of nozzle blocks. The frame comprises means for adjusting the tempering conditions effected to the surface of the glass to follow the shape of the surface of the glass. The directions of the flows of the substance in gaseous phase is adjusted such that the distance between the areas where a substance impinges the surface of a glass, between at least one pair of adjacent nozzle blocks and at least one row is kept substantially constant, regardless of the shape of the glass.
Patent DE-69525859-T2 (DE)
Inventor: JINNO SHUJI
IPC: C07D337/14
Filed: 1995-09-28
Granted: 2002-10-24
Abstract: Providing a novel tricyclic, condensed heterocyclic compound having an anti-oxidative action and being promising for use in pharmaceutical agents, cosmetics, chemical products and the like. By chemical synthesis, a novel anti-oxidative, tricyclic, condensed heterocyclic compound represented by the following formula: <CHEM> (wherein X-Y represents CH2-C=O, CH2-CH2 or CH=CH; Z represents O, S, or S=O; R1 to R8 represent independently those selected from the group consisting of hydrogen atom, a hydroxyl group, a halogen group, a lower alkyl group, a lower alkoxyl group, a lower alkyl ketone group and CF3; and at least two of R1 to R4 are hydroxyl groups); and the salts thereof are provided. The compound has an anti-oxidative activity at the sale degree as or higher than the activity of  alpha -tocopherol, so the compound is promising as a therapeutic drug for a variety at diseases, such as cancer, arteriosclerosis, or liver diseases, in which it is believed that biological lipid peroxides may be involved.
Patent DE-69526886-T2 (DE)
Inventor: DURAND GRAZIELLA
IPC: E01C7/26
Filed: 1995-08-03
Granted: 2003-01-16
Abstract: In a composite emulsion for the running surfaces of traffic, contg. a bituminous binder and a resin, the emulsion is applied cold. The bituminous binder includes a cross-linking agent for the resin, and the bituminous binder and the resin are each emulsified in water before being mixed.
Patent DE-69530727-T2 (DE)
Inventor: CAMPBELL SHANNON K
IPC: A61K8/34
Filed: 1995-07-24
Granted: 2004-04-29
Abstract: A two component desensitizing dentifrice composition is disclosed which comprises a first dentifrice component containing a desensitizing potassium salt such as potassium nitrate and a second dentifrice component containing a second desensitizing agent other than a potassium salt the such as SnF2, the second desensitizing agent being incompatible with the potassium salt, the first and second dentifrice components being maintained separate from the other until dispensed for application to teeth requiring relief from dentine hypersensitivity. <MATH>