Patent EA-001871-B1 (EA)
Title: Method of producing material for purification of physiological liquids of organism, and method of producing the material
Inventor: DAVANKOV VADIM
IPC: A61M1/34
Filed: 1998-12-30
Abstract: 1. A method for purification of physiological liquids of organism, comprising removing a physiological liquid with toxicants from a patient, passing a physiological liquid through a material adopted to remove toxic compounds in the molecular range of 300 to 30000 Dalton from a physiological liquid and returning the liquid to the patient, wherein such a material is used which contains surface exposed functional groups with a greater hydrophilicity than those of the vinyl groups and produced by chemical treatment of hydrophobic divinylbenzene copolymer with the surface exposed vinyl groups. 2. A material for purification of physiological liquids of organism by passing a physiological liquid through a patient and having a structure adopted to remove toxic compounds in the molecular range of 300 to 30000 Dalton from a physiological liquid, wherein it contains surface exposed functional groups with a greater hydrophilicity than those of the vinyl groups and produced by chemical treatment of hydrophobic divinylbenzene copolymer with the surface exposed vinyl groups. 3. A material as defined in claim 2 wherein said porous hydrophobic divinylbenzene copolymer comprises a copolymer of divinlbenzene with comonomers selected from the group of styrene, ethylstyrene, acrylonitrile, and buthyl methacrylate. 4. The material as defined in claim 2, wherein surface exposed functional groups with a greater hydrophilicity and greater biocompatibility than those of the vinyl groups are grafted hydrophilic polymeric chains selected from the group of polymers of 2-hydroxyethyl methacrylate, N-vinylpyrrolidine, N-vinylcaprolactame and N-acrylamide. 5. The material as defined in claim 2, wherein surface exposed functional groups with a greater hydrophilicity and greater biocompatibility than those of the vinyl groups are products of oxidation of said vinyl groups to epoxy groups and subsequent addition of polar compounds selected from a group which includes water, ethylene glycole, small primary or secondary amines, 2-hydroxyethyl-amine. 6. The material as defined in claim 4, wherein surface exposed functional groups with a greater hydrophilicity and greater biocompatibility than those of the vinyl groups are products of oxidation of said vinyl groups to epoxy groups and subsequent addition of small primary or secondary amines or 2-hydroxyethyl-amine and depositing high-molecular-weight poly(trifluoroethoxy) phosphazene. 7. A method of producing a material for purification of physiological liquids of an organism comprising providing a porous hydrophobic divinylbenzene copolymer which has a size, a shape, and a structure so as to remove toxic compounds in the molecular range of 300 to 30000 Dalton from a physiological liquid and which initially has surface exposed vinyl groups,wherein said porous hydrophobic divinylbenzene copolymer is chemically treated such that to chemically modify said vinyl groups so as to form different surface exposed functional groups said surface exposed functional groups with a greater hydrophilicity and greater biocompatibility. 8. The method of producing a material as defined in claim 7, wherein said chemical modification of vinyl groups resulting in the formation of different surface exposed functional groups with a greater hydrophilicity and greater biocompatibility than those of the vinyl groups without affecting noticeably the poros structure and hydrophobic interior of the initial divinlbenzene copolymer, includes grafting polymerization in an aqueous or aqueous organic media of water soluable monomers selected from the group of polymers of 2-hydroxyethyl methacrylate, N-vinylpyrrolidine, N-vinylcaprolactame and N-acrylamide. 9. The method of producing a material as defined in claim 7, wherein said chemical modification of vinyl groups resulting in the formation of different surface exposed functional groups with a greater hydrophilicity and greater biocompatibility than those of the vinyl groups without affecting noticeably the poros structure and hydrophobic interior of the initial divinlbenzene copolymer, includes oxidation of said vinyl groups to epoxy groups and follwed by addition to the epoxy group of polar compounds selected from a group which includes water, ethylene glycole, small primary or secondary amines, 2-hydroxyethyl-amine. 10. The method as defined in claim 9, wherein said oxidation of said vinyl groups to epoxy groups is followed by addition to the epoxy groups of small primary or secondary amines or 2-hydroxyethyl-amine and then depositing high-moleculae-weght poly(trifluoroethoxy) phosphaxene from its solution in an organic solvent via complexing the above polyphosphazene with the susface exposed amino groups.