Patent IL-117343-A (IL)
Title: Arylsulfonylamino hydroxamic acid derivatives, process for their preparation and pharmaceutical compositions containing them
IPC: A61P43/00
Filed: 1996-03-04
Abstract: Compounds of the formula ot the pharmaceutically acceptable salts thereof, wherein n is 1 to 6; X is hydroxyl, (C1-C6) alkoxy or NR1R2 wherein R and R2are each independently selected from the group consisting of hydrogen, (C1-C6) alkyl, piperidyl, (C1-C6) alkylpiperidyl, (C6-C10) arylpiperidyl, (C5-C9) heteroarylpiperidyl, (C6-C10) aryl (C1-C6) alkylpiperidyl, יריעה מס' 11 6/2002 (C5-C9) heteroaryl (C1-C6) alkylpiperidyl, (C1-C6) acylpiperidyl, (C6C10) aryl, (C5-C9) heteroaryl, (C6-C-10) aryl (C1-C6) alkyl, (C5-C9) heteroaryl (C1-C6) alkyl, (C6-C10) aryl (C6-C10) aryl, (C6-C10) aryl (C6-C10) aryl (C1-C6) alkyl, (C3-C6) cycloalkyl, (C3-C6) cycloalkyl (C1-C6) alkyl, R5 (C2-C6) alkyl, (C1-C5) alkyl (CHR5) (C1-C6) alkyl wherein יריעה מס' 12 6/2002 117343/2 R5 is hydroxy, (C1-C6) acyloxy, (C1-C6) alkoxy, piperazino, (C1-C6) acylamino, (C1-C6) alkylthio, (C6-C10) arylthio, (C1-C6) alkylsulfinyl, (C6-C10) arylsulfinyl, (C1-C6) alkylsulfonyl, (C6-C10) arylsulfonyl, amino, (C1-C6) alkylamino, (C1-C6) alkyl)2 amino, (C1-C6) acylpiperazino, (C1-C6) alkylpiperazino, (C6-C10) aryl (C1-C6) alkylpiperazino, (C5-C9) heteroaryl (C1-C6) alkylpiperazino, morpholino, thiomorpholino, piperidino or pyrrolidino; R6 (C1-C6) alkyl, (C1-C5) alkyl (CHR6) (C1-C6) alkyl wherein R6 is piperidyl, (C1-C6) alkylpiperidyl, (C6-C10) arylpiperidyl, (C6-C10) aryl (C1-C6) alkylpiperidyl, (C5-C9) heteroarylpiperidyl or (C5-C9) heteroaryl (C1-C6) alkylpiperidyl; and CH (R7) COR8 wherein R7 is hydrogen, (C1-C6) alkyl, (C6-C10) aryl (C1-C6) alkyl, (C5-C9) heteroaryl (C1-C6) alkyl, (C1-C6) alkylthio (C1-C6) alkyl, (C6-C10) arylthio (C1-C6) alkyl, (C1-C6) alkylsulfinyl (C1-C6) alkyl, (C6-C10) arylsulfinyl (C1-C6) alkyl, (C1-C6) alkylsulfonyl (C1-C6) alkyl, (C6-C10) arylsulfonyl (C1-C6) alkyl, hydroxyl (C1-C6) alkyl, amino (C1-C6) alkyl, ((C1-C6) alkylamino (C1-C6) alkyl, (C1-C6) alkylamino)2 (C1-C6) alkyl, R9R10 NOC (C1-C6) alkyl or R9OCO (C1-C6)alkyl wherein R9 and R10 are each independently selected from the group consisting of hydrogen, (C1-C6) alkyl, (C6-C10) aryl (C1-C6) alkyl and (C5-C9) heteroaryl (C1-C6) alkyl; and R8 is 6/2002 117343/3 R11O or R11 R12N wherein R11 and R12 are each independently selected from the group consisting of hydrogen, (C1-C6) alkyl, (C6-C10) aryl (C1-C6) alkyl and (C5-C9) heteroaryl (C1-C6) alkyl; or R1 and R2, or R9 and R10, or R11 and R12 may be taken together to form an azetidinyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, indolinyl, isoindolinyl, tetrahydroquinolinyl, tetrahydroisquinolinyl, (C1-C6) acylpiperazinyl (C1-C6) alkylpiperazinyl, (C6-C10) arylpiperazinyl, (C5-C9) heteroarylpiperazinyl or a bridged diazabicyloalkyl ring selected from the group consisting of יריעה מס' 13 6/2002 117343/4 wherein r is 1, 2 or 3; m is 1 or 2; p is 0 or 1; and Q is hydrogen, (C1-C3) alkyl or (C1-C6) acyl; R3 and R4 are each independently selected from the gorup consisting of hydrogen, (C1-C6) alkyl, trifluoromethyl, trifluoromethyl (C1-C6) alkyl, (C1-C6) alkyl (difluromethylene), (C1-C3) alkyl (difluoromethylene) (C1-C3) alkyl, (C6-C10) aryl, (C5-C9) heteroaryl, (C6-C10) aryl (C1-C6) alkyl, (C5-C9) heteroaryl (C1-C6) 6/2002 alkyl, (C6-C10) aryl (C6-C10) aryl, (C6-C10) aryl (C6-C10) aryl (C1-C6) alkyl, (C3-C6) cycloalkyl, (C3-C6) cycloalkyl (C1-C6) alkyl, hydroxy (C1-C6) alkyl, (C1-C6) acyloxy (C1-C6) alkyl, (C1-C6) alkoxy (C1-C6) alkyl, piperazinyl (C1-C6) alkyl, (C1-C6) acylamino (C1-C6) alkyl, piperidyl, (C1-C6) alkylpiperidyl, (C6-C10) aryl (C1-C6) alkoxy (C1-C6) alkyl, (C5-C9) heteroaryl (C1-C6) alkoxy (C1-C6)alkyl, (C1-C6) alkylthio (C1-C6) alkyl, (C1-C6) alkylsulfinyl (C1-C6) alkyl, (C6-C10) arylsulfinyl (C1-C6) alkyl, (C1-C6) alkylsulfonyl (C1-C6) alkyl, (C6-C10) arylsufonyl (C1-C6) alkyl, amino (C1-C6) alkyl, (C1-C6) alkylamino (C1-C6) alkyl, ((C1-C6) alkylamino)2 (C1-C6) alkyl, R13 CO(C1-C6) alkyl wherein R13 is R20O or R20R21N wherein R20 and R21 are