baber/WOPTO huggingface dataset:
Patent EP-4259152-A1 (EP)
Title: Cemtirestat disulfide, prodrug of aldo-keto reductase inhibitor, preparation, pharmaceutical composition and use thereof
Inventor: STEFEK MILAN
IPC: A61K31/53
Filed: 2021-12-13
Abstract: The present invention relates to a novel prodrug of aldo-keto reductase inhibitor II based on its disulfide (system name "disulfane") of formula I, to a process of the preparation of disulfide of formula I, to the use of disulfide of formula I to inhibit the aldo-keto reductases AKR1B1 and AKR1B10, to the use of disulfide of formula I in the prevention or treatment of diseases in which the activity of the aldo-keto reductases AKR1B1 and AKR1B10 is a key etiological factor for their formation and development, the use of disulfide of formula I for the prevention or treatment of cancer originating from chronic inflammation, namely cancer of colon, lung, breast, liver, prostate, pancreas, endometrial and cervix. The invention also relates to the use of disulfide of formula I for the treatment of cancer as an adjuvant therapeutic in combination with clinically used chemotherapeutics, which may also be a substrate for aldo-keto reductases such as doxorubicin and daunorubicin. Disulfide of formula I itself is inactive as an inhibitor of aldo-keto reductases AKR1B1 and AKR1B10, but after oral or parenteral administration it is metabolized in the body, preferably in cancer cells characterized by increased reduction potential due to GSH content markedly increased compared to healthy cells, producing two molecules of cemtirestat of formula II the active inhibitor of aldo-keto reductase. The disulfide of formula I according to the invention may also have the advantage that it is better absorbed in the acidic environment of the tumors than cemtirestat of formula II alone. Disulfide of formula I can be used alone or in the form of pharmaceutically acceptable forms: a mono- or dibasic salt, mono- or diesters, amides, or combinations thereof or other pharmaceutical agents, optionally in combination with other anti-inflammatory or anti- cancer therapeutics. (I)
Patent EP-4268155-A1 (EP)
Inventor: SONNLEITNER HERMANN
IPC: G06Q10/00
Filed: 2021-12-23
Abstract: Die Erfindung betrifft ein System für die Echtheitsprüfung eines Produktes (2), gemäß welchem das Produkt (2) mit einer Kennzeichnung (3) versehen ist, deren Information durch einen Detektor (6, 16, 20) ausgelesen wird und über ein Informationsnetzwerk (8) an eine Datenbank (9) gesandt wird und mit dort hinterlegten Informationen abgeglichen wird, wobei als ein Ergebnis des Abgleichs eine Entscheidung bezüglich Echtheit oder Unechtheit des Produktes (2) generiert wird und das Ergebnis dieser Entscheidung am Ort des Produktes (2) signalisiert wird. Das Produkt (2) ist ein verpacktes Lebensmittel und der Detektor (6, 20) ist in einem Kühlschrank (1) angeordnet, in welchem das Produkt (2) platziert ist. Weiters betrifft die Erfindung ein System für die optische Identifizierung von oben auf einer durchsichtigen Regalfläche (11, 22) befindlichen Produkten (2).
Patent EP-4185822-A1 (EP)
Title: System and methods for enhanced thermal syphoning
Inventor: STRANGE WARREN ROSS
IPC: F24T10/17
Filed: 2021-07-12
Abstract: An enhanced thermal syphoning system, comprising a first well and a second well extending though a permeable geological layer, each well having: an inlet channel to introduce a fluid into the well and an inlet valve to control an inlet fluid flow rate into the inlet channel; an outlet channel to draw geologically heated fluid from the well and an outlet valve to control an outlet fluid flow rate from the outlet channel; and an opening in the inlet channel adjacent the permeable geological layer, wherein fluid in the inlet channel of the first well and the inlet channel of the second well is communicated therebetween via the permeable geological layer, the fluid entering and exiting the inlet channels through the openings therein, such that each inlet and each outlet valve can be adjusted to vary a flow volume of the fluid between the first well and the second well.
Patent EP-4187641-A1 (EP)
Inventor: JIN DANDAN
IPC: H01M10/0525
Filed: 2021-07-27
Abstract: The present invention provides a negative electrode piece, a preparation method thereof and a lithium-ion battery including the negative electrode piece. The negative electrode piece includes a negative electrode current collector, a first negative electrode active material layer, a second negative electrode active material layer, and a negative electrode tab, where the negative electrode tab is arranged on a surface of one side of the negative electrode current collector, and a surface of one side of the negative electrode current collector near the negative electrode tab and providing with the negative electrode tab is coated with the first negative electrode active material layer, a surface of one side of the negative electrode current collector away from the negative electrode tab and providing with the negative electrode tab is coated with the second negative electrode active material layer; the first negative electrode active material layer includes a first negative electrode active material, and the second negative electrode active material layer includes a second negative electrode active material. The negative electrode piece of the present invention can effectively improve a phenomenon of lithium precipitation at a position of a tab of a lithium-ion battery with a STP structure, improve a cycle life of the lithium-ion battery; and effectively alleviate a deformation of a battery cell caused by lithium precipitation at the same time.
Patent EP-4190776-A1 (EP)
Title: Salt and crystal form of ketohexokinase inhibitor and use thereof
Inventor: WENG ZHENTAO
IPC: C07D403/14
Filed: 2021-07-27
Abstract: Disclosed are a crystal form and a pharmaceutically acceptable salt of a ketohexokinase inhibitor, a preparation method therefor, and a pharmaceutical composition and use thereof, which specifically relate to a crystal form of a compound of formula (1), a pharmaceutically acceptable salt of the compound of formula (1), and a crystal form of the pharmaceutically acceptable saltserving as the KHK inhibitor, a preparation method therefor, a pharmaceutical composition containing the crystal form, the pharmaceutically acceptable salt, and the crystal form of the pharmaceutically acceptable salt, and use of the crystal form and the pharmaceutically acceptable salt of the compound of formula (1), and the crystal form of the pharmaceutically acceptable salt in the preparation of a medicament for treatment and/or prevention of a KHK-mediated disease or related disease.
Patent EP-4176732-A1 (EP)
Inventor: HIBI Naruhiro
IPC: A23L11/00
Filed: 2021-08-06
Abstract: Provided is a starch-containing solid composition having both preferable elasticity during water retention and low viscosity during water retention when heated under water-containing conditions. The composition satisfies all of (1) to (4) below. (1) The starch content in the composition is 20 mass% or more in terms of dry mass. (2) (a) and/or (b) below are satisfied. (a) 300 pieces/mm2 or less of starch grain structures are observed in a 6% suspension of a pulverized product of the composition. (b) The gelatinization peak temperature is below 120°C as measured using a rapid viscoanalyzer when a 14 mass% water slurry of the pulverized composition is heated from 50°C to 140°C at a heating rate of 12.5°C/min. (3) The degree of gelatinization of starch in the composition is 50 mass% or more. (4) For the composition, the following [value α] is 60% or less, and the following [value β] is 35% or more. [Value α] In a molecular weight distribution curve obtained by analyzing purified starch under [condition A], the purified starch being obtained by treating the composition in a 40-fold amount of water at a constant temperature of 90°C for 15 minutes and then using [procedure a], the ratio of the area under the curve in a section in which the molecular weight logarithm is at least 5.0 and less than 6.5 to the area under the entire curve. [Value β] In the molecular weight distribution curve, the ratio of the area under the curve in a section in which the molecular weight logarithm is at least 6.5 and less than 8.0 to the area under the entire curve. ([procedure a] and [condition A] are as described in the specification.)
Patent EP-4098900-A1 (EP)
Inventor: DOHI NAGAO
IPC: F16D41/08
Filed: 2021-06-15
Abstract: To provide a rotation transmission state switching device having a more simplified configuration. The rotation transmission state switching device comprises a clutch device comprising a first rotating member having a first-rotating-member-side engaging portion, a second rotating member having a second-rotating-member-side engaging portion, a third rotating member having a third-rotating-member-side engaging portion; and an engaging element having an engaging-element-side first engaging portion that engages with the first-rotating-member-side engaging portion, an engaging-element-side second engaging portion that engages with the second-rotating-member-side engaging portion, and an engaging-element-side third engaging portion that engages with the third-rotating-member-side engaging portion; and a restriction device configured so as to be able to switch between a state where rotation of the first rotating member is allowed and a state where rotation of the first rotating member is restricted; torque transmission between the second rotating member and the third rotating member being allowed when rotation of the first rotating member is allowed by the restriction device, whereas torque transmission between the second rotating member and the third rotating member is not possible when rotation of the first rotating member is prevented by the restriction device.
Patent EP-4224020-A1 (EP)
Inventor: WAN XUEFENG
IPC: F15B11/08
Filed: 2021-09-24
Abstract: A liquid path system (12), comprising a flow path selection valve (10), a pump assembly (14), and a fluid network (60). The fluid network (60) comprises a reservoir (64), a first flow channel, a second flow channel, and a reaction device (62). The first flow channel and the second flow channel are each independently in flow communication with the reservoir (64) and the reaction device (62). The pump assembly (14) is in communication with the flow path selection valve (10). The pump assembly (14) is in communication with the fluid network (60). The flow path selection valve (10) is configured to rotate between a first valve position and a second valve position. In the case that the flow path selection valve (10) is at the first valve position, the pump assembly (14) induces the liquid in the reservoir (64) to flow to the reaction device (62) through the first flow channel, and in the case that the flow path selection valve (10) is at the second valve position, the pump assembly (14) induces the liquid in the reservoir (64) to flow to the reaction device (62) through the second flow channel.
Patent EP-4231235-A1 (EP)
Title: Display drive method, module and chip, electronic device and storage medium
Inventor: WANG DONGJIAN
IPC: G06T7/223
Filed: 2021-10-13
Abstract: The present disclosure relates toa display driving method, module, chip, electronic device, and a storage medium. Some embodiments of the present disclosure provide a display driving method, module, chip, electronic device, and a storage medium to improve the quality of the image presented.
Patent EP-4232910-A1 (EP)
Inventor: MILLER TRAVIS
IPC: G06F15/00
Filed: 2021-10-22
Abstract: Disclosed here are methods of analyzing product-related datasets using a computer system including a product data collection; receiving a product-related data submission; identifying system-identified terms in the submission; generating a query dataset comprising search elements, such as lexical vector(s), semantic vector(s), or both; querying the product data collection and identifying datasets that sufficiently match aspect(s) of the query dataset; comparing the content of the submission and matching datasets to provide an output such as a determination of an error or omission in the submission, identifying a relationship between the submission product and a product associated with an identified dataset; or assessing one or more product status characteristics; and optionally performing additional applications, such as generating a regulatory authority submission based on the determination that the submission product is subject a regulatory requirements based on the comparison of the submission with the identified datasets.
Patent EP-4237126-A1 (EP)
Inventor: ZORNER PAUL
IPC: B01D53/62
Filed: 2021-10-29
Abstract: L'invention en question fournit des compositions et des procédés pour réduire l'empreinte carbone de production du bétail. Des compositions de traitement du sol à base de microbes réduisent les émissions de gaz à effet de serre provenant de la production d'aliments pour bétail, et, à leur tour, améliorent la santé et la productivité d'animaux d'élevage.
Patent EP-4241531-A1 (EP)
Title: A secure communication system
Inventor: HILLIS W DANIEL
IPC: H04W76/10
Filed: 2021-11-05
Abstract: A secure communication system enabling secure transport of information is disclosed. The system comprises a secure network with one or more packet processing units connected by links through an internal communication system. The secure network transports packets of information between credentialed and authenticated agents. Each packet is associated with a visa issued by a visa service. The visa specifies the procedures governing the processing of the packet by the packet processing units as it is transported along a compliant flow, between agents thorough the network, according to a set of policies specified in a network configuration. Packet processing units include docks and forwarders. Adaptors serving the agents communicate with the network through tie-ins to docks. The system also includes and admin service, accessible to one more admins, that facilitates configuration and management of the network.
Patent EP-4207741-A1 (EP)
Inventor: YAO XIUJUN
IPC: H04N5/232
Filed: 2021-10-29
Abstract: The present disclosure provides an image processing method, a controller, an image processing robot, and a non-transitory computer-readable storage medium and relates to the technical field of robots. The image processing method comprises : controlling a reference light source to project a reference line in the lengthwise direction of a photographed object; controlling a camera to move in the lengthwise direction of the photographed object to photograph different segments of the photographed object and to acquire images of the segments of the photographed object, the images comprising different reference line segments of the reference line; aligning the images by using the reference line segments that the images comprise as a reference; and stitching the aligned images to acquire a full image of the photographed object. The present disclosure allows the images of the segments of the photographed object to be aligned, thus increasing the image quality of the stitched image.
Patent EP-4239442-A1 (EP)
Inventor: AN SEONGYONG
IPC: G06F1/16
Filed: 2021-12-03
Abstract: According to one embodiment of the present invention, an electronic device may comprise: a housing including a first housing and a second housing that can slide with respect to the first housing; a flexible display arranged to be supported by the housing, the flexible display including a first area exposed to the outside of the electronic device and a second area, which extends from the first area and is withdrawn from the housing or is drawn into the housing according to the sliding of the second housing; a cavity structure positioned in the second housing; and a wireless communication circuit configured to transmit and/or receive a signal of a selected or designated frequency band through the cavity structure. Various other embodiments are possible.
Patent EP-4264508-A1 (EP)
Title: Method and apparatus for controlling training data
Inventor: ZHU HUAISONG
IPC: G06N20/00
Filed: 2021-12-16
Abstract: A method and apparatus for controlling training data. A method performed by a network device (850) comprises determining control information for training data. The method further comprises transmitting the control information for training data to a wireless device (860). According to the control information, the transmitting and receiving of the training signals is carried out. The training data is used for air-interface machine learning.
Patent EP-4318835-A1 (EP)
Inventor: SAIONJI Rei
IPC: H02G5/06
Filed: 2021-03-26
Abstract: In a solid insulated bus (100), a cylindrical grounding sheet (11) having electrical conductivity and flexibility is attached to a plurality of insulation adapters (1) and a bus (2). If a ground wire (12) is connected to the grounding sheet (11), a first grounding dielectric layer (10a) on a surface of each of the insulation adapters (1) and a second grounding dielectric layer (10b) on a surface of the bus (2) are grounded. The grounding sheet (11) has a cylindrical shape, and thus the grounding sheet (11) is easily brought into close contact with the first grounding dielectric layer (10a) and the second grounding dielectric layer (10b), and an attaching operation is easy, whereby an operation time at the time of installing a gas-insulated switchgear can be shortened.
Patent EP-4148896-A1 (EP)
Inventor: SU HUASHENG
IPC: H01M50/528
Filed: 2021-07-30
Abstract: Embodiments of the present application provide a battery cell, a battery, an electrical device, and a manufacturing method and device for the battery cell, which belong to the technical field of batteries. A battery cell comprises: an electrode assembly, a housing and an end cap. The electrode assembly has a first tab. The housing has an opening for accommodating the electrode assembly. The end cap is configured to connect with the housing and cover the opening. The end cap has an abutting surface and a welding groove, the abutting surface is configured to abut against the first tab, and the welding groove is recessed from one side of the end cap away from the electrode assembly towards the abutting surface. The end cap forms a connection part between the abutting surface and the bottom surface of the welding groove, and the connection part is configured for being welded with the first tab. The end cap is provided with a reinforcing part, the reinforcing part is protruded from the bottom surface, and the reinforcing part is configured to enhance the strength of the connection part. The reinforcing part can play a role of strengthening the connection part used for being welded with the first tab, improve the strength of the connection part, reduce the risk of failure of the battery cell due to the damage of the connection part under pressure, and improve service life of the battery cell.
Patent EP-4315584-A1 (EP)
Title: Convertisseur de puissance
Inventor: WIJEKOON PINIWAN THIWANKA BANDARA
IPC: H02M7/483
Filed: 2021-04-21
Abstract: La présente invention concerne un convertisseur de puissance pour la conversion de tension, le convertisseur de puissance comprenant : une première borne, une deuxième borne et une troisième borne, et une borne CA pour coupler une tension CA ; un premier circuit de commutation unidirectionnelle commandable ; un deuxième circuit de commutation unidirectionnelle commandable ; un circuit de commutation bidirectionnelle commandable ; une première diode connectée dans une direction de courant vers l'avant entre la troisième borne et le premier circuit de commutation unidirectionnelle commandable ; et une deuxième diode connectée dans la direction de courant vers l'avant entre le deuxième circuit de commutation unidirectionnelle commandable et la troisième borne.
Patent EP-4311407-A1 (EP)
Inventor: CHANG MOHUAI
IPC: H01L29/78
Filed: 2021-12-13
Abstract: A trench field-effect transistor (FET) device (100A) includes a plurality of active trenches (102) that extends along a first axis and are distributed along a second axis perpendicular to the first axis. Each active trench (102) includes a gate electrode (124) and a shield electrode (126). The trench FET device (100A) further includes two or more termination trenches (104, 106) fully filled with a dielectric material, extend along the second axis, and arranged adjacent to the plurality of active trenches (102). In addition, the shield electrode (126) of each of the plurality of active trenches (102) is arranged to abut with a respective one of the two or more termination trenches (104, 106) at each end. The trench FET (100A) is based on an edge termination concept that offers the benefit of eliminating the need for a transition region, which results in an increased voltage blocking capability of the trench FET device (100A).
Patent EP-4124405-A1 (EP)
Inventor: BAYERSCHEN RALF
IPC: G05B19/418
Filed: 2022-07-29
Abstract: Es wird eine Vorrichtung zum Schneiden von Figuren (K) aus einem in einer Transportrichtung (T) transportierten Materialband (1a, 1b) vorgeschlagen. Die Vorrichtung hat eine Spendereinheit (2a) und eine Empfängereinheit (2b) zum Transportieren des Materialbandes (1a, 1b) in der Transportrichtung (T), sowie eine Bearbeitungsstation (11) mit einer Schneideinrichtung (5) zum Schneiden von Schnittfiguren (K). Weiter hat sie einen Greifer (3) mit mindestens einem Stempel (7) zur Aufnahme der geschnittenen Schnittfiguren (K) und eine Steuerung (12) zum Steuern der Geschwindigkeit des Materialbandes (1a, 1b), der Bewegung der Schneideinrichtung (5) und der Bewegung des Greifers (3). Die Bearbeitungsstation (11) ist innerhalb des Abstandes einer Lücke (X) zwischen Spendereinheit (2a) und Empfängereinheit (2b) des Materialbandes (1a, 1b) angeordnet, wobei die Schneideinrichtung (5) in Arbeitsstellung gegenüber dem Greifer (3) angeordnet ist. Dazwischenliegend verlaufen das Materialband (1a, 1b) und die Stirnseite des Greifers (3) mit Abstand parallel zueinander. Der Zugriff des Greifers (3) erfolgt senkrecht zum Materialband (1a, 1b) auf die Schnittfiguren (K).
Patent EP-4005505-A1 (EP)
Title: Articulatable surgical end effector with asymmetric shaft arrangement
Inventor: HUNTER MORGAN R
IPC: A61B17/072
Filed: 2017-12-21
Abstract: A surgical tool assembly. A surgical end effector is movably coupled to a shaft assembly by an articulation joint that is configured to facilitate selective articulation of the surgical end effector relative to the shaft assembly. The shaft assembly includes a proximal end portion and a distal end portion. The distal end portion is operably coupled to the articulation joint. An elongate notch is provided in the distal end portion and is located on one lateral side of a shaft axis that is defined by the shaft assembly. The shaft assembly may be configured to prevent the distal end portion from buckling when an axial actuation motion is applied to the proximal end.
Patent EP-4036053-A1 (EP)
Title: Machine de distribution de boisson equipée d'un système de mesure de la quantité de boisson restante dans un contenant
Inventor: MANSEAU CHARLES
IPC: B67D1/12
Filed: 2022-01-13
Abstract: L'invention concerne une machine de distribution de boisson (1) comportant une chambre de réception d'un fût formant une recharge de boisson et un dispositif de soutirage (14) de la boisson contenue dans le fût, ladite machine de distribution de boisson (1) reposant sur des pieds (4, 6) et comportant un circuit de commande comprenant un système de mesure d'une quantité restante de boisson dans le fût. Le système de mesure d'une quantité restante de boisson comporte au moins un capteur de poids agencé dans uniquement au moins un des pieds (6) placés à l'opposé du dispositif de soutirage (14).