baber/WOPTO huggingface dataset:
Patent CA-2294604-A1 (CA)
Inventor: WINKEL J G J VAN DE
IPC: A61K39/395
Filed: 1998-06-25
Abstract: Transgenic animals expressing Fc receptors and uses for the animals in testing the efficacy of human antibodies and in generating novel antibodies are described.
Patent CA-2295661-A1 (CA)
Inventor: REID DAVID GARTH
IPC: B05B9/00
Filed: 1998-07-10
Abstract: A hand-held dispenser of hot water intended for weed control purposes has a handle (300) containing a hose connection (110), a flow regulator (111) and a power switch (103). The handle (300) is connected to a tube (302) which contains a main electric water heating element (107) surrounded by a tube (304) through which water can flow from the bottom of the wand towards the handle (300) before being piped through an exit tube to the nozzle (114).      A temperature sensor (108) is positioned adjacent the handle (300) so that amount of power supplied to the heating element (107) can be regulated. One version uses a microprocessor to control the heating, the other uses two heating elements and a thermostat.
Patent CA-2299883-A1 (CA)
Title: Interactive photometric calculations system
Inventor: KNOBLE DAVID W
IPC: H04N1/00
Filed: 2000-02-24
Abstract: An interactive system on a server via which a client can remotely submit data used to making photometric calculations in which the system has one or more interrogative interfaces is provided. Data is requested from the client via the interrogative interfaces when the client accesses the system. Data is received from the client by the interactive system. Photometric calculations are performed using the data received from the client and the results of the photometric calculations are delivered to the client.
Patent CA-2300295-A1 (CA)
Title: Revetements ameliores fabriques avec l'asphalte de la trinite
Inventor: NICHOLAS DOLLY
IPC: C08L95/00
Filed: 1998-08-04
Abstract: L'invention porte sur des revêtements améliorés comprenant l'asphalte de la Trinité (TLA) connu également sous le nom d'asphalte naturel de la Trinité ou Epure et utilisé dans cette invention comme matière première. Ces revêtements améliorés sont des peintures, des amorces, des agents de scellement, des époxy, des matériaux de couverture, des matériaux insonorisants, des marquages routiers, des membranes et bien d'autres produits de revêtement. Ces revêtements sont sans danger pour l'environnement et présentent de meilleures caractéristiques que ceux de la technique antérieure. Pour obtenir ce type de revêtement, on combine l'asphalte de la Trinité et au moins un autre type connu de matière première tel que des supports solides (fibres de carbone, etc.) et/ou des supports liquides (eau, alcool, etc.), et/ou des supports gazeux (gaz polaires, gaz non polaires, etc.).
Patent CA-2300885-A1 (CA)
Title: Method for isolating anionic organic substances from aqueous systems using cationic polymer nanoparticles
Inventor: SCHEWITZ JENS
IPC: B01J41/04
Filed: 1998-08-21
Abstract: The invention relates to a method for isolating anionic organic substances from aqueous systems using polymer nanoparticles with cationic pH-sensitive surface groups. Extraction can be carried out directly from diluted solutions, biological media (blood plasma, serum, urine, etc.) and complex buffer systems (e.g. PCR preparations containing detergents) without prior derivatization of the samples or addition of binding buffers. After separation from the surrounding medium the conjugates of the corresponding substances and polymer nanoparticles obtained in this manner can be purified through additional washing steps and effectively desalinated. Owing to the pH-sensitivity of the basic surface groups, the bound substances can be released in a targeted manner after separation by modification of the pH of the medium. By using volatile bases contamination of the released samples with ionic residues can be avoided. By adding small quantities of SDS and acetonitrile during the separation stage, the sensitivity of the method can be raised further, especially when the substances to be isolated are present in low concentrations (<1µmol/L). The method is a method of extraction with universal application, suitable for both low-molecular anionic compounds as well as peptides, nucleic acids and nucleic acid derivatives. Recovery rates are up to 100 %.
Patent CA-2302992-A1 (CA)
Title: Methods for generating high titer helper-free preparations of recombinant aav vectors
Inventor: FUNG VICTOR P
IPC: C12N5/10
Filed: 1998-09-04
Abstract: This invention provides methods and compositions for producing high titer, substantially purified preparations of recombinant adeno-associated virus (AAV) that can be used as vectors for gene delivery. At the onset of vector production, AAV producer cells of this invention typically comprise one or more AAV packaging genes, an AAV vector comprising a heterelogous (i.e. nonAAV) transgene of interest, and a helper virus such as an adenovirus. The AAV vector preparations produced are generally replication incompetent but are capable of mediating delivery of a transgene of interest (such as a therapeutic gene) to any of a wide variety of tissues and cells. The AAV vector preparations produced according to this invention are also substantially free of helper virus as well as helper viral and cellular proteins and other contaminants. Also provided is a quantitative, highthroughput assay useful in the assessment of viral infectivity and replication, as well as in the screening of agents that affect viral infectivity and/or replication.
Patent CA-2304454-A1 (CA)
Title: Plant protection mat, especially in the form of a perforated disk
Inventor: BOHRINGER EBERHARD
IPC: A01G13/02
Filed: 1998-09-24
Abstract: The invention relates to a plant protection mat, especially in the form of a perforated disk (1). When in use, the plant protection mat is situated above the root ball of a plant as a ground covering. The perforated disk (1) is made from a coconut fleece comprising coconut fibres joined with latex. Said coconut fibres of the perforated disk (1) are fixed with contour-forming stiffening edges (5, 6). The perforated disk also has pore structures (P, P') with different opening widths in the areas of the top and bottom surface cover areas (7, 8).
Patent CA-2305533-A1 (CA)
Title: Multilamellar coalescence vesicles (mlcv) containing biologically active compounds
Inventor: BONI LAWRENCE T
IPC: A61K38/00
Filed: 1998-10-01
Abstract: A method for producing multilamellar coalescence vesicles (MLCVs) containing increased amounts of biologically active compound is disclosed. The method involves hydrating at least one powdered lipid in an aqueous buffer at a temperature above the phase transition temperature of the highest melting lipid to form multilamellar vesicles, reducing the size of the multilamellar vesicles to about 20-400 nm to produce small unilamellar vesicles (SUVs) or large unilamelar vesicles (LUVs) or a mixture thereof, and incubating the SUVs, LUVs or mixture thereof with a biologically active compound in in aqueous solution under sufficient conditions to form MLCVs containing the biologically active compound without the use of an organic solvent, a freeze-thawing step or a dehydration step MLCVs produced by this method contain increased amounts of biologically active compound over prior art liposomes produced with an organic solvent, a freeze-thawing step or a dehydration step and fewer vesicles are substantially free of biologically active compound
Patent CA-2310830-A1 (CA)
Inventor: WEISSMAN WALTER
IPC: F02B3/06
Filed: 1998-12-09
Abstract: The invention is directed towards a method for adjusting the NO2 to NO content of a diesel engine's exhaust without affecting engine performance. The NO2 to NO ratio is adjusted by varying the amount and timing of secondary hydrocarbon injection during the engine's expansion stroke. The appropriate amount of secondary injected hydrocarbon and the appropriate injection timing are determined from calibration values obtained by direct engine measurements and the desired NO2:NO ratio.
Patent CA-2311458-A1 (CA)
Title: Multiple channel pipetting device
Inventor: MALVEY EDWARD J III
IPC: C40B60/14
Filed: 1998-10-26
Abstract: This invention is a multiple channel pipetting device for aspirating and dispensing volumes of liquid using disposable or non-disposable tips. The device is comprised of a main body made of a hard synthetic material with multiple channels and an associated ram plate activated by a four-quadrant synchronous drive. The drive assembly is mounted on four standoffs, and the ram plate moves up and down by the means of four lead screws moved with a synchronous fibrous belt moved with a motor. A moveable plate mounted to the bottom of the device to remove disposable tips is activated by a set of automated ejector plate arms. The entire device can be mounted in a self-contained housing or attached to another device allowing it to be moved.
Patent CA-2313300-A1 (CA)
Title: Label panel container carrier
Inventor: OLSEN ROBERT
IPC: B65D67/02
Filed: 2000-06-30
Abstract: This invention relates to a package of a plurality of containers unitized with a flexible carrier. The carrier is constructed from a plastic planar sheet having a plurality of container receiving openings arranged in longitudinal rows and transverse ranks. A panel extends from a longitudinal edge of the planar sheet that is arranged to either remain flat and tight with respect to the package or, alternatively, follow an external contour of the package.
Patent CA-2314473-A1 (CA)
Inventor: DEKEYNE ANNE
IPC: A61P25/20
Filed: 2000-07-20
Abstract: -71-     L'invention concerne de nouveaux composés répondant à la formule (I):  (voir formule I)  dans laquelle ~ représente une liaison simple ou double conférant optionellement un caractère aromatique au cycle qui les porte; R1 représente (a) un atome d'hydrogène, (b) un groupement alkyle, (c) un groupement -R6-aryle ou -R6-cycloalkyle ou -R6- hétérocycle dans lequel R6 représente un groupement alkylène, (d) un groupement -CO2R7 dans lequel R7 représente un groupement alkyle, un groupement aryle, un groupement cycloalkyle, un hétérocycle ou un groupement -R6-aryle, -R6-cycloalkyle ou -R6-hétérocycle dans lequel R6 est tel que défini précédemment, (e) un groupement -COR8 dans lequel R8 représente un atome d'hydrogène, un groupement alkyle, un groupement aryle, un groupement cycloalkyle, un hétérocycle ou un groupement -R6-aryle, -R6-cycloalkyle ou -R6-hétérocycle dans lequel R6 est tel que défini précédemment, ou (f) un groupement -CONHR8 dans lequel R8 est tel que défini précédemment, ou R1 n'existe pas lorsque l'atome d'azote qui le porte, porte déjà une double liaison intracyclique; R 2 représente (a) un groupement cyano, (b) un groupement -CO2R8 dans lequel R8 est tel que défini précédemment, (c) un groupement -CONHR8 dans lequel R8 est tel que défini précédemment, (d) un groupement monoalkylaminoalkylaminocarbonyle ou dialkyl-aminoaminoalkylaminocarbonyle, (e) un groupement -NR8R9 dans lequel R8 est tel que défini précédemment et R9 représente un groupement R8 défini précédemment, ( f) un    -72-    groupement -NH-CO2R7 dans lequel R7 est tel que défini précédemment, ou (g) un groupement -COR8 dans lequel R8 est tel que défini précédemment; R3 et R4 forment ensemble, avec l'atome de carbone qui les porte, un cycloalkyle; R5 représen te un atome d'hydrogène ou un groupement alkyle ou arylalkyle; Ra, Rb, Rc et Rd, identiques ou différents, représentent indépendamment l'un de l'autre un atome d'hydrogène  ou d'halogène, ou un groupement alkyle, hydroxy, alkoxy, trihalogénoalkyle, trihalo-génoalkoxy, nitro, cyano, amino, alkylamino, dialkylamino, aryle, arylalkyle, carboxy, alkylcarbonyloxy, acyle, aryloxy ou arylalkoxy; leurs isomères ainsi que leu rs sels d'addition à un acide ou à une base pharmaceutiquement acceptable. Les composés selon l'invention sont utiles à titre de médicaments pour le traitement de la dépression, de la psychose, de ls schizophrénie, de la phobie, de l'anxiété, des attaques de panique, des troubles du sommeil, des troubles de l'appétit, des troubles impulsifs et agressifs, des troubles sexuels ou de la migraine.
Patent CA-2314681-A1 (CA)
Title: A method for crystallizing polyols and sugars
Inventor: VEZZANI CORRADO
IPC: A23L27/30
Filed: 2000-07-28
Abstract: A method for the continuous crystallization of sugars or polyols, comprising the steps of: - arranging in a thin, turbulent and dynamic layer a continuous flow of melted mass of a compound selected among the group comprising sugars and polyols, with at least 98% of dry material, and a mass of said compound in crystalline form as a crystallization seed; - advancing said thin layer of material along a cooling wall at a temperature between -15°C and +5°C; - granulating the material while said thin layer is advanced along the cooling wall, thus obtaining granules of the crystallized compound, and - cooling said granules to room temperature, after a predetermined maturation time.
Patent CA-2316165-A1 (CA)
Title: Homopolymers and copolymers of ethylene
Inventor: CHAI CHOON KOOI
IPC: C08J5/18
Filed: 1999-01-05
Abstract: Ethylene homopolymers and copolymers having a broad molecular distribution, excellent toughness and improved processability are disclosed. These polymers may be prepared by use of a single metallocene catalyst system in a single reactor in the gas phase. These polymers of density typically 0.85-0.95 are defined in particular by their melt strength (MS) and long chain branching (LCB) characteristics and are particularly suitable for use in low density film applications.
Patent CA-2318921-A1 (CA)
Title: Pharmacological uses of optically pure (+)-bupropion
Inventor: MCCULLOUGH JOHN R
IPC: A61P25/34
Filed: 1999-01-28
Abstract: Methods and compositions are disclosed utilizing the optically pure (+)-isomer of bupropion to assist in smoking cessation, for treating smoking and nicotine addiction, and for treating pain, including, but not limited to, chronic pain, neuropathetic pain, and reflex sympathetic dystrophy, and other disorders such as narcolepsy, chronic fatigue syndrome, fibromyalgia, seasonal affective disorder and premenstrual syndrome, while avoiding adverse affects associated with racemic bupropion.
Patent CA-2319659-A1 (CA)
Inventor: GAIBLER DENNIS W
IPC: B60G17/052
Filed: 1999-01-27
Abstract: A suspension system for a vehicle (10) includes a first hydraulic circuit(42), a second hydraulic circuit (44) and a connection (58) between the first hydraulic circuit (42) and the second hydraulic circuit (44). The first hydraulic circuit (42) is operatively connected to a first side of the vehicle(10), and is selectively controllable to move the first side of the vehicle(10). The second hydraulic circuit (44) is operatively connected to a second side of the vehicle (10), and is selectively controllable to move the second side of the vehicle (10). The first hydraulic circuit (42) and the second hydraulic circuit (44) operate together in a first mode when the connection(58) between the first hydraulic circuit (42) and the second hydraulic circuit(44) is opened to move the first and second sides of the vehicle (10) in a same direction. The first hydraulic circuit (42) and the second hydraulic circuit (44) operate independently of each other in a second mode when the connection (58) is closed.
Patent CA-2319737-A1 (CA)
Inventor: JEMILI KANAAN
IPC: G10L25/51
Filed: 1999-02-02
Abstract: La présente invention concerne un appareil et des procédés permettant d'intégrer des informations en filigrane dans un signal de couverture (2), tel qu'un signal audio, un signal vidéo ou un signal d'image fixe, de façon que l'on ne peut effacer les informations en filigrane sans détériorer le signal de couverture. Selon la présente invention, on soumet le signal de couverture à une modulation de phase (6) avant d'y intégrer les informations en filigrane (8), la quantité ou le degré de modulation de phase étant modifié (3,5) au moins pour chaque filigrane différent devant être intégré dans un exemplaire ou une copie du signal de couverture. Par conséquent, si deux copies d'un même signal de couverture, chacune contenant un filigrane différent, sont moyennées ou combinées dans le but d'effacer les informations en filigrane, le signal de couverture subira une annulation de phase qui rendra inutilisable toute copie illicite de ce signal.
Patent CA-2320358-A1 (CA)
Inventor: GANZ OLIVER
IPC: G02B6/00
Filed: 1999-12-06
Abstract: According to a prior method for producing a tube of glassy material, especially quartz glass, a hollow cylindrical tube rounds of glassy material is fed in an essentially vertical manner to a heating zone, where said tube rounds is heated and drawn off downwards to the tube without using tools and by producing a transition area from the tube rounds to the tube. The diameter and the wall thickness of the tube are continually measured and the measured geometrical data of the tube are used for generating a control signal by means of which a pressure difference between the pressure P1 in the inner chamber of the tube rounds, the transition area and the tube and the pressure P2 in the heating chamber is controlled in the heating zone at least in the transition area from the tube rounds to the tube and the tube area adjacent thereto. Said method should be refined in such a way that a broader spectrum of hollow cylindrical tube rounds can be processed to tubes having desired internal and external dimensions. The aim of the invention is to produce tubes whose ratio from the outer diameter (DRa) to the inner diameter (DRi) is greater than the ratio from the outer diameter (DHa) to the inner diameter (DHi) of the tube rounds. The pressure P1 in the inner chamber of the transition area and of the tube rounds and of the tube is maintained at a value which is less than the value of the pressure P2 in the heating chamber, whereby the pressure P1 is maintained by means of a suction pump.
Patent CA-2322426-A1 (CA)
Title: Diagnostic for metastatic prostate cancer
Inventor: WU GUANG-JER
IPC: C12Q1/6886
Filed: 1999-03-02
Abstract: The present disclosure provides methods for the diagnosis of metastatic prostate cancer and/or the prediction of the metastatic ability of prostate cancer in prostate biopsy tissue. Metastatic ability of prostate cancer is positively correlated with the level of transcriptional and translational expression of the MUC18 coding sequence in the neoplastic tissue. Methods for the determination of MUC18 protein synthesis include Western blots, ELISA, radioimmunoassay, immunofluorescence, and other immunoassays using MUC18specific antibody and suitable detection means. Methods for measurement of transcriptional expression of the MUC18 coding sequence include Northern hybridizations and quantitative reverse transcriptase-polymerase chain reaction analyses. Absence of or very low MUC18 expression in the prostate tumor tissue is associated with nonmetastatic cancer, while relatively high levels of MUC18 expression are predictive of prostate cancer which is likely to metastasize or which has already metastasized. The present disclosure provides an improved diagnostic tool to aid the medical community in the choice of appropriate treatment regimens for prostate cancer patients.
Patent CA-2323236-A1 (CA)
Inventor: MOORE KEVIN W
IPC: C07K19/00
Filed: 1999-03-08
Abstract: Nucleic acids encoding mammalian, e.g., primate or rodent receptors, purified receptor proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.
Patent CA-2323626-A1 (CA)
Inventor: KUKULIES BRIAN HEINZ
IPC: B29C33/38
Filed: 1999-03-05
Abstract: Cette invention se rapporte à un procédé servant à fabriquer un moule, en prenant au moins un matériau de panneau polymère ayant une température de transition vitreuse inférieure à la température de fusion d'un matériau de moulage thermoplastique et en retirant au moins une partie de ce matériau de panneau polymère pour former, par conception assistée par ordinateur, une image inverse d'un article voulu devant être moulé. Dans une variante, cette invention se rapporte à un procédé servant à fabriquer un moule, en prenant au moins un matériau de panneau polymère et en retirant, par conception assistée par ordinateur, à l'aide d'une opération d'usinage par commande numérique, par ordinateur, au moins une partie de ce matériau de panneau polymère, afin de former une image inverse d'un article voulu devant être moulé. Cette invention se rapporte en outre à un procédé servant à fabriquer un prototype ou un prototype fonctionnel, à un tel prototype et à un tel prototype fonctionnel obtenus à l'aide de ces procédés, ainsi qu'à un moule polymère servant à la fabrication de ces prototypes et de ces prototypes fonctionnels.
Patent CA-2326240-A1 (CA)
Title: Bone plate with bone screw securing means
Inventor: MINFELDE RICHARD-LAURENT
IPC: A61B17/70
Filed: 1999-04-30
Abstract: Implant for the cervical spine comprising an anterior plate (1) for maintaining a bone graft, bone anchorage screws (6, 7, 8) for the plate and means (22) for blocking the screws and preventing any migration of the screws, characterized in that the blocking means comprises at least one slide (22) slidably mounted on the plate so as to be applicable on at least one anchorage screw head (15, 16). The slide cooperates with means (33, 34) for retaining the slide on the head of the screw. The slide may be formed by a thin platelet (22a) which is provided with lateral flanges (25) and is slidable in a complementary cavity (18) provided in the plate (1) while being flush with the surface of the plate (1). The plate (1) includes ramps (26) for retaining the slide (22) on which the flanges (25) are slidable, the slide (22) being slidable to a position in which it at least partly overlaps the heads of the associated screws (6 or 7) and is locked in position by suitable means.
Patent CA-2326849-A1 (CA)
Title: Hybrid vehicle, hybrid vehicle driving system and method of driving a hybrid vehicle
Inventor: OHSUGA MINORU
IPC: B60W20/00
Filed: 2000-10-26
Abstract: A hybrid vehicle driving system has a transmission means (22) for selectively transmitting the output torque of an internal-combustion engine (10), the output torque of an electric motor (19) or a composite torque produced by combining the respective output torques of the internal-combustion engine (10) and the electric motor (19) to driving wheels. The hybrid vehicle driving system includes a.turbogenerator (7) capable of converting energy of the exhaust gas discharged from the internal-combustion engine (10) into electric energy, and an electrical connecting means (1) for electrically connecting the turbogenerator (7) to the electric motor (19). The hybrid vehicle driving system is controlled so that the engine (10) operates on a lean mixture for the largest possible part of the total operating time of the engine (10).
Patent CA-2327010-A1 (CA)
Inventor: HAMILTON JEFFREY R
IPC: A44B11/00
Filed: 2000-11-28
Abstract: The buckle includes a web adjustment member which further includes a first lacing bar, a second lacing bar and a third lacing bar about which webbing is laced. The first and second lacing bars are positioned relatively proximate to each other so that a pinch point is formed in the webbing proximate to the first and second lacing bars. This pinch point resists loosening of the webbing with respect to the buckle. A third lacing bar, which is relatively distant from the first and second lacing bars, maintains the pinch point during rotation of the buckle.
Patent CA-2328360-A1 (CA)
Title: Ameliorations apportees ou reliees a des inhibiteurs de protease
Inventor: RAY DAVID
IPC: A61P25/28
Filed: 1999-04-14
Abstract: L'invention concerne un médicament destiné à induire une amélioration neuro-cognitive chez un sujet mammifère. Ledit médicament comprend une substance inhibant l'acylpeptide hydrolase (ACPH), et un vecteur, excipient ou diluant physiologiquement acceptable.