baber/WOPTO huggingface dataset:
Patent IL-110688-A0 (IL)
Title: Substituted dihydropyranopyridines, their preparation and pharmaceutical compositions containing them
IPC: A61K31/505
Filed: 1994-08-17
Abstract: PCT No. PCT/EP94/02700 Sec. 371 Date Jan. 24, 1996 Sec. 102(e) Date Jan. 24, 1996 PCT Filed Aug. 12, 1994 PCT Pub. No. WO95/05381 PCT Pub. Date Feb. 23, 1995The present invention is concerned with compounds of formula    <IMAGE>  (I)  the pharmaceutically acceptable acid addition salts thereof, the +E,uns N+EE -oxides thereof and the stereochemically isomeric forms thereof, wherein =a1-a2=a3-a4= is a bivalent radical of formula:=N-CH=CH-CH=(a),=CH-N=CH-CH=(b),=CH-CH=N-CH=(c),=CH-CH=CH-N=(d),wherein in said bivalent radicals one or two hydrogen atoms can be substituted by halo, hydroxy, C1-6alkyl or C1-6alkyloxy; R1 is hydrogen or C1-6alkyl; R2 is hydrogen or C1-6alkyl; R3 is hydrogen or C1-6alkyl; Alk1 is C1-5alkanediyl; Alk2 is C2-15alkanediyl; Q is a five- or six-membered heterocyclic ring containing at least one nitrogen atom or a radical of formula    <IMAGE>  (aa)  wherein R4 is hydrogen, cyano, aminocarbonyl or C1-6alkyl; R5 is hydrogen, C1-6alkyl, C3-6alkenyl or C3-6alkynyl; R6 is hydrogen or C1-6alkyl; or R5 and R6 taken together may form a bivalent radical of formula -(CH2)4- or -(CH2)5-. Pharmaceutical compositions, preparations and use as a medicine are described.
Patent IL-136098-A0 (IL)
Title: Remote control system which minimizes screen refresh time by selecting compression algorithm
IPC: H04N7/173
Filed: 1998-11-13
Abstract: A system is provided for the remote control of one computer from another in which selectable compression speeds are utilized to minimize overall screen refresh time. In one embodiment, an algorithm selection module at one computer chooses the highest compression available corresponding to a worst case scenario, followed by measurement of the compression time and the transmission time, with the ratio of compression time to transmission time being used to select a decreased compression, thereby to lower compression time and consequently lower the overall screen refresh time. By adjusting both the send time and the compression time on the transmit side, the above ratio can be made to equal one, which corresponds to the most efficient utilization of the available bandwidth and CPU power, which in turn translates into the quickest screen refresh time for the remote control operation.
Patent IL-154146-A0 (IL)
Title: Isolation of microbial oils
IPC: A23D9/00
Filed: 2001-08-01
Abstract: The extraction of a microbial or single cell oil, for example comprising one or more polyunsaturated fatty acids (PUFAs), directly from microbial cells is disclosed which avoids the need for solvents. After fermentation, the microbial cells are pasteurised, washed and the cell walls lysed or disrupted by a mechanical (e.g. homogenisation), physical (boiling or drying), chemical (solvents) or enzymatic (cell wall degrading enzymes) technique. The oil (containing the PUFA) is then separated from the resulting cell wall debris. This is achieved by centrifugation, which results in an oily phase (top layer) that contains the oil which that can be separated from an aqueous phase (containing the cell wall debris). The oil can then be extracted and if necessary the PUFA can be purified or isolated from the oil.
Patent IL-159981-A0 (IL)
Title: Direct binding assay for identifying inhibitors of hcv polymerase
IPC: G01N33/542
Filed: 2002-08-05
Abstract: A method for identifying compounds binding to HCV polymerase comprising the steps of: contacting said HCV polymerase or an analog thereof with a probe formula I: wherein A is O, S, N, NR<SUP>1</SUP>, or CR<SUP>1</SUP>, wherein R<SUP>1 </SUP>is defined herein; ----- represents either a single or a double bond; R<SUP>2 </SUP>is selected from: H, halogen, R<SUP>21</SUP>, OR<SUP>21</SUP>, SR<SUP>21</SUP>, COOR<SUP>21</SUP>, SO<SUB>2</SUB>N(R<SUP>22</SUP>)<SUB>2</SUB>, N(R<SUP>22</SUP>)<SUB>2</SUB>, CON(R<SUP>22</SUP>)<SUB>2</SUB>, NR<SUP>22</SUP>C(O)R<SUP>22 </SUP>or NR<SUP>22</SUP>C(O)NR<SUP>22 </SUP>wherein R<SUP>21 </SUP>and each R<SUP>22 </SUP>is defined herein; B is NR<SUP>3 </SUP>or CR<SUP>3</SUP>, wherein R<SUP>3 </SUP>is defined herein; with the proviso that, when A is not N, then one of A or B is either CR<SUP>1 </SUP>or CR<SUP>3</SUP>, K is N or CR<SUP>4</SUP>, wherein R<SUP>4 </SUP>is defined herein; L is N or CR<SUP>5</SUP>, wherein R<SUP>5 </SUP>has the same definition as R<SUP>4 </SUP>defined above; M is N or CR<SUP>7</SUP>, wherein R<SUP>7 </SUP>has the same definition as R<SUP>4 </SUP>defined above; R<SUP>5 </SUP>is C(Y<SUP>1</SUP>)Z wherein Y<SUP>1 </SUP>is O or S; and Z is N(R<SUP>6a</SUP>)R<SUP>6 </SUP>or OR<SUP>6</SUP>, wherein R<SUP>6a </SUP>is H or alkyl or NR<SUP>61</SUP>R<SUP>62 </SUP>wherein R<SUP>61 </SUP>and R<SUP>62 </SUP>are defined herein; and R<SUP>6 </SUP>is H, alkyl, cycloalkyl, alkenyl, Het, alkyl-aryl, alkyl-Het; or R<SUP>6 </SUP>is wherein R<SUP>7 </SUP>and R<SUP>8 </SUP>and Q are as defined herein; Y<SUP>2 </SUP>is O or S; R<SUP>9 </SUP>is H, (C<SUB>1-6 </SUB>alkyl), (C<SUB>3-7</SUB>)cycloalkyl or (C<SUB>1-6</SUB>)alkyl-(C<SUB>3-7</SUB>)cycloalkyl, aryl, Het, (C<SUB>1-6</SUB>)alkyl-aryl or (C<SUB>1-6</SUB>)alkyl-Het, all of which optionally substituted with R<SUP>90</SUP>; or R<SUP>9 </SUP>is covalently bonded to either of R<SUP>7 </SUP>or R<SUP>8 </SUP>to form a 5- or 6-membered heterocycle; or a salt thereof; where the probe comprises a detectable label attached to any suitable position, whereby said probe binds to an HCV polymerase or an analog thereof and is capable of being displaced by an inhibitor thereof.
Patent IL-164693-A0 (IL)
Title: Thermal bend actuator for a micro electromechanical device
IPC: F03G7/06
Filed: 2004-10-19
Abstract: A micro electro-mechanical device embodied within an ink ejection nozzle having an actuating arm that is caused to move an ink displacing paddle when heat inducing electric current is passed through the actuating arm is disclosed. The paddle is located in an ink chamber and the actuating arm passes through an actuator aperture in the chamber. The actuating arm has an inner arm and an outer arm and electrical current is supplied to the inner arm to cause bending of the actuating arm so as to move the paddle to eject a droplet of ink from the ink chamber. To prevent spurious bending modes and to force the actuating arm to undergo a desired bending mode so that the paddle moves appropriately to eject the ink droplet, the actuating arm includes connecting rods which connect side edges of the inner and outer arms and torsion bars which connect the connecting rods. The torsion bars and connecting rods reduce the likelihood of unwanted bending modes taking place which may effect the expulsion of an ink droplet from the chamber.
Patent IL-165135-A0 (IL)
Title: Production of crystalline materials by using high intensity ultrasound
IPC: B01D9/00
Filed: 2004-11-10
Abstract: A crystalline material sufficiently pure for use in pharmaceuticals may be made by forming a saturated solution of the material, changing the temperature of the solution so it becomes supersaturated, and subjecting the solution to irradiation by high intensity ultrasound, the frequency of the ultrasound being scanned over a range of frequencies. For example the ultrasound may be varied between 19.5 and 20.5 kHz, and this variation may be sinusoidal. Preferably the ultrasound is provided only briefly, say for less than 5 s, before allowing the solution to cool gradually without further irradiation. The ultrasound may be applied using a vessel with an array of ultrasonic transducers attached to a wall, so each transducer radiates no more than 3 W/cm<SUP>2 </SUP>yet the power dissipation within the vessel is between 25 and 150 W/litre. This method can reduce the metastable zone width to less than 10 K. It is applicable in particular to aspartame.
Patent IL-174694-A0 (IL)
Title: Method and apparatus for route discovery within a communication system
IPC: H04L12/28
Filed: 2006-03-30
Abstract: During route discovery in an ad-hoc communication network, an overlay transceiver ( 104 ) determines a plurality of "seed" nodes that lie between the source and the destination node. The seed nodes are notified of the desire to discover a route between the source and the destination node. Once notified, the seed nodes immediately broadcast route discovery messages. All nodes ( 101 ) within the underlay communication system ( 110 ) periodically listen for route discovery messages. If any node within the underlay communication system ( 110 ) receives a route discovery message having the same route identification, route information between the two seeds will be provided to the overlay transceiver ( 104 ), giving the overlay communication system a "path" between the seeds. Once the overlay transceiver ( 104 ) receives route information between all seeds, it then determines an appropriate route between source and destination devices, and broadcasts this information to the source and the destination devices.
Patent IL-179859-A0 (IL)
Title: Oral sustained release formulation of tedisamil with gastric retention properties
Filed: 2006-12-05
Abstract: The present invention relates to a novel sustained release formulation with gastric retention properties comprising tedisamil or a pharmaceutically acceptable salt thereof and the use of this formulation in the prevention and treatment of atrial fibrillation, atrial flutter and cardiac ischemia.
Patent IL-186083-A0 (IL)
Title: Method and system for digital pen assembly
Filed: 2007-09-19
Abstract: A digital pen comprises a skeleton and a removable skin, the skeleton holding together in fixed relationship, an electric circuit, and a first acoustic transmitter, detached from said electric circuit, and configured to transmit acoustic signals, and the removable skin comprising a housing fitting over said skeleton, a digital pen system comprises said digital pen, a method of manufacturing differentiated digital pens comprises preparing identical elongated skeletons, inserting within a plurality of said elongated skeletons, an electric circuit, an acoustic transmitter, detached from said electric circuit, and configured to transmit acoustic signals, preparing a range of differentiated housings for said elongated skeletons, and selecting one of said housings from said range for respective ones of said plurality of elongated skeletons, fixing said selected housing onto said respective elongated skeleton, thereby to provide a range of differentiated digital pens from said identical skeletons.
Patent IL-186129-A0 (IL)
Title: Inhibitors of ribonucleotide reductase subunit 2 and uses thereof
IPC: C12N15/113
Filed: 2007-09-20
Abstract: The present application relates to inhibitors of ribonucleotide reductase subunit 2 (R2), and methods and compositions related to the R2 inhibitors. In certain embodiments, the R2 inhibitors include nucleic acids, such as for example siRNAs
Patent IL-192762-A0 (IL)
Title: Method for identifying cell differentiation factors
IPC: A61K48/00
Filed: 2008-07-10
Abstract: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
Patent IL-198019-A0 (IL)
Title: Large calibre ammunition loaded from the rear
Filed: 2009-04-06
Abstract: The ammunition (1) has a projectile attached to a combustible skirt (2) closed by a cap (4), and a connection dome (3) provided between the skirt and the cap. The dome includes a sidewall cooperating with the skirt and another side wall extending from the former sidewall and cooperating with the cap. The dome includes connection units e.g. tabs (10), assuring connection with the skirt when the units are folded by the cap on one of the side walls of the skirt.
Patent IL-200172-A0 (IL)
Title: Improved process for the production of daptomycin
Filed: 2009-07-30
Abstract: The present invention relates to an improved process for the production of Daptomycin by fermentation with Streptomyces roseosporus, in the presence of n-decanal or Cuphea oil as sources of the n-decanoyl side chain. These reagents allow to reduce toxicity effects on the bacteria and to avoid the use of solvents in the feeding solution.
Patent RO-127732-A0 (RO)
Title: Process for operating a bilateral electrical brain stimulator device in closed loop
Inventor: BĂZĂVAN RADU-GEORGE
IPC: A61N1/05
Filed: 2012-04-24
Abstract: The invention relates to a process for operating a bilateral electrical brain stimulator device, in closed loop, for the patients affected by neural diseases, suffering from motor deficiencies of Parkinson type or Essential Tremor-type for the purpose of diminishing the symptoms thereof. According to the invention, the process consists in applying a stimulating electrical signal at the level of neural tissue by means of some electrodes (6) implanted in each brain hemisphere (a and b) into a stimulating target location (c), then collecting a brain response signal; the stimulating signal and the collected signal are transmitted by means of electrically conductive extension (7) comprising two bipolar channels (7a and 7b); the bipolar channel (7a) transmits the signal collected from the target location (c) to a precise differential amplifier (8), then the result is applied to a filter block (9) used for rejecting a stimulation artefact and bandpass filtering; the resulting signal is acquired by a decision digital processor (10) with the role of analyzing, modifying and transmitting the wave shape on the basis of a regulating criterion (11) ; the resulting signal is applied to a signal generator (12) as an element shaping the characteristics of the emitted signal ; the wave shape emitted as a result of the generator (12) is the stimulating signal which is transmitted to the target location (c) by means of the bipolar channel (7b) towards the implanted quadrupolar electrodes.
Patent RO-137277-A0 (RO)
Title: Mouthwash with β-cyclodextrin inclusion complex with clove essential oil
Inventor: MITITELU MAGDALENA
IPC: A61K6/69
Filed: 2022-10-25
Abstract: The invention relates to a mouthwash with natural active principles of xylitol, β-cyclodextrin inclusion complex with essential oils of cloves, cinnamon, myrrh and tea tree, intended for the hygiene of the oral cavity, the mouthwash having an antimicrobial, antifungal, anti-inflammatory, immunomodulatory, soothing, odorizing and healing action. According to the invention, the mouthwash is made by combining distilled water with sodium bicarbonate, xylitol, beta-cyclodextrin inclusion complex with clove essential oil, solubilizer for essential oils, cinnamon essential oil, myrrh essential oil and tree tea essential oil, in the following association ratio expressed in parts by weight: 90...92.5 : 0.4...0.5 : 3...3.5 : 1...1.5 : 1. ..1.5 : 0.5...1 : 0.5...1 : 0.5...1.
Patent CU-21703-A1 (CU)
Title: Metodo de obtencion de crema para el tratamiento de afecciones vasculares, cicatrices y queloides.
Inventor: CAMPO VILLALOBO MARIA
IPC: A61K9/06
Filed: 1985-03-07
Abstract: Esta invención se relaciona con la medicina, en las especialidades de Angiología y Caumatología. El método para la preparación de esta crema consiste en fundir a temperatura de 70 grados centígrados de 1,50 a 2 gr de Monoestearato de Glicérido con 1,5 a 2 gr.de Alcohol Cetílico. Disolver de 2,8 a 3 gr de Propilparabeno, de 2,6 a 2,8 gr de Metilparabeno, de 1,80 a 2 gr de Polisolvato-80, de 77 a 80 gr. de Bencidamina Clorhidrato en 60 a 80 gr de Agua Purificada. Unir las fases anteriores con agitación constante a temperatura de 70 grados centígrados, con enfriamiento. Levigar de 27 a 30 Unidades Internacionales de Heparina Sódica con 0,80 a 0,90 gr de Propilenglicol, incorporándose a la emulsión a temperatura de 60 grados centígrados con agitación constante y enfriamiento hasta que el semisólido empiece a cuajar a una temperatura de 50 grados centígrados; dejar enfriar y envasar. Con esta invención se obtiene una crema que aplicada localmente se concentra en grandes cantidades en la zona afectada, empleandose en el tratamiento de patologías cosméticamente molestas al paciente. El objetivo perseguido es mejorar las zonas hiperpigmentadas por estasis venoso crónico, ablandar los tejidos endurecidos en las cicatrices hipertróficas y los queloides, eliminar la inflamación, pigmentación y dolor en los hematomas, flebitis superficiales profundas y las contusiones.
Patent ZW-8684-A1 (ZW)
Title: A spray-discharge device for a deformable container
Inventor: DONALD WORKUM
IPC: B05B11/04
Filed: 1984-06-14
Abstract: A deformable spray dispenser comprises a valve unit which is capable of axial displacement within the container with respect to the container cover between a spray-discharge position and an air-suction position. The valve unit supports a member for shutting-off the eductor tube in its air-suction position. The valve unit is provided with a valve cap having an external face which is applied against an internal face of the container cover in the spray-discharge position and cooperates with the internal face so as to form a nozzle for discharging liquid through the container-cover orifice in an atomized spray pattern.
Patent IE-910110-A1 (IE)
Title: Hollow wall anchor with enhanced holding strength
IPC: F16B13/08
Filed: 1991-01-14
Abstract: A data-driven processor which has a packet assembling unit to add a tag information to the sequentially inputted data when the input data has no tag information, such as destination address or the like, thereby enabling the data to be inputted without using an external circuit, such as a host processor, and improving the data input rate and which also has a packet outputting and rearranging unit for rearranging an output packet stream in a predetermined order to thereby output the data information only, so that it is possible that the data is outputted without any external circuit, such as a host processor, the output rate is improved, and the data output is executed in a predetermined order.
Patent MA-23039-A1 (MA)
Inventor: LOUISE GAIL SCOTT
IPC: C11D3/10
Filed: 1993-11-25
Abstract: The present invention encompasses cleaning compositions comprising a nonionic surfactant system containing a mixture of highly hydrophilic and highly hydrophobic nonionic surfactants. The present invention also encompasses a method of cleaning wherein said compositions are diluted in water before they are used to clean hard surfaces. The present invention also encompasses the diluted cleaning composition obtained in the method according to the present invention.
Patent MA-27138-A1 (MA)
Title: Composes heteroaryliques condenses a substituant azabicyclique pour le traitement d'une maladie
Inventor: WALKER DANIEL PATRICK
IPC: A61P25/02
Filed: 2004-04-01
Abstract: DEPOSANT Société dite: PHARMACIA & UPJOHN COMPANY REVENDICATION DE PRIORITES US 2 Octobre 2001 60/326,565 US 2 Octobre 2001 60/326,629 US 15 Novembre 2001 60/334,886 US 12 Décembre 2001 60/339,633 Voir en annexe le titre de l'invention et le texte de l'abrégé Composés hétéroaryliques condensés à substituant azabicyclique pour le traitement d'une maladie La présente invention propose des composés de   formule I, dans laquelle le substituant azabicyclo répond aux formules (II-VII), W répond aux formules (VIII-X). Ces composés peuvent être sous forme de sels ou compositions pharmaceutiques, de leurs mélanges racémiques ou de leurs énantiomères purs. Les composés de formule I sont utiles dans des produits pharmaceutiques, en cas d'implication d'(alpha)7.
Patent MA-27901-A1 (MA)
Title: Antagonistes du recepteur de l'acetylcholine muscarinique
Inventor: BELMONTE KRISTEN E
IPC: A61K31/46
Filed: 2006-01-06
Abstract: Des antagonistes des récepteurs d'acétylcholine muscariniques et des méthodes pour leur utilisation sont proposés.
Patent MA-39257-A1 (MA)
Title: Bloc - entraineur des textiles tisses et non -tisses en plypropylene
Inventor: ZAHIR MOHAMED
IPC: B65H11/00
Filed: 2016-08-09
Abstract: Le bloc-entraineur des textiles tissés et non-tissé en polypropylène, objet de cette invention, est caractérisé en ce qu'il comporte un nouveau «concept d'entrainement rectiligne» des textiles en général, et les tissus non-tissé en polypropylène en particulier. Les techniques antérieures d' entrainement des feuilles ou films de textile non-tissé, caractérisées par l'introduction de nombreux cylindres rotatifs, ne concerne pas la technique objet de cette invention. Le bloc-entraineur, objet de cette invention, contribue, à la fois, à l'entrainement et au maintien de la matière à entrainer, de manière rectiligne, régulière et uniforme, tout au long du parcours conçu dans tout ligne de fabrication des articles en textile tissé et non-tissé. Alignés transversalement ou longitudinalement en fonction de la laize des rouleaux de textiles à entrainer, et appliqués contre une structure plane et lisse, l'ensemble des blocentraineurs permet l'entrainement idéal de la matière à vitesse rapide, sans étirement ni déformation. La présente invention est avantagée, par rapport aux techniques précédentes, par la réduction de l'encombrement des lignes de production continue, par la réduction de quantité importante de matériaux, par la réduction des espaces d'exploitation, par l'annulation des risques d'étirement et de déformation des textiles à entrainés, par la souplesse et la rapidité des mouvements. Ces avantages engendrent un gain économique en investissement et en productivité, et auront un impact important sur le marché, particulièrement celui des sacs et sachets, par production élevée et coût moindre.
Patent UY-23671-A1 (UY)
Title: Embalaje antirrobo
Inventor: CHAO RODRIGUES LUCIANO
IPC: A47F7/024
Filed: 1993-11-05
Abstract: La presente invención se refiere a un embalaje antirrobo especialmente idealizado para cartones de cigarrillos. El embalaje está compuesto por un armazón (10) y por una tapa (20), ambas de sección rectangular. El armazón está dotado de aberturas rectangulares (11) en sus caras superior e inferior y de un orificio (12) en la parte del medio próxima al borde de entrada. La tapa tiene sección rectangular para que pueda calzar en el interior del armazón y está dotada de una etiqueta electrónica (21) con parte superior cónica (23). La traba de la tapa está hecha por medio de una pieza cilíndrica (22) introducida en el orificio del armazón. La traba de la tapa podrá ser realizada alternativamente, por medio de dispositivos mecanicos, tales como candados, cerraduras, etc. La figura 1 es una visión en perspectiva del embalaje desmontado.
Patent UY-25111-A1 (UY)
Title: Composicion de polisacarido modificado hidrofobicamente en productos para el cuidado personal
Inventor: MODI JASHAWANT J
IPC: A61K47/36
Filed: 1998-07-24
Abstract: Una composición para el cuidado personal compuesta de: (a) desde alrededor de 0.1% hasta alrededor de 99% en peso de un sistema de vehículo que comprende un polímetro polisacárido soluble en agua no iónico modificado hidrofóbicamente que comprende una estructura de polímetro de polisacárido soluble en agua y una fracción hidrofóbica seleccionada a partir del grupo que consiste de 3-alcoxi-2-grupo hidroxipropil donde la fracción alquilo es una cadena recta ramificada que tiene 2 a 6 átomos de carbono, alquilo c3-c7, alquil-aliro y mezclas de ellos y (b) por lo menos un ingrediente para el cuidado personal. Dicha estructura del polímero modificada hidrofóbicamente se selecciona a partir del grupo de hidroxietilcelulosa (HEC9), hidroxipropilcelulosa(HPC), metilcelulosa(MC), etc, y asar, dextran, goma de frijol, almidón, guar, y sus derivados no iónicos, y mezclas de ellos. Estos polisacáridos se utilizan para el cuidado personal.