baber/WOPTO huggingface dataset:
Patent PT-1481990-E (PT)
Title: A-33 related antigens and their pharmacological uses
Inventor: FONG SHERMAN
IPC: A61P11/00
Filed: 1998-11-20
Abstract: A33 related antigens PRO301, PRO362 and PRO245, are new. Independent claims are also included for the following: (1) a nucleic acid comprising DNA having at least 95% sequence identity to: (a) a DNA molecule encoding PRO301 comprising amino acids 28-235 of a 299 amino acid sequence (given in the specification); (b) a DNA molecule encoding the same mature polypeptide encoded by cDNA in ATCC 209432 (designated DNA40628-1216); or (c) the complement of DNA in (a); (2) a nucleic acid comprising DNA having at least 80% sequence identity to: (a) a DNA molecule encoding PRO362 comprising amino acids 1-321 or 1-X (X = any of residues 271-280) of a 321 amino acid sequence (given in the specification); (b) a DNA molecule encoding the same mature polypeptide encoded by cDNA in ATCC 209620 (designated DNA45416-1251); or (c) the complement of DNA in (a); (3) production of PRO301, PRO362 or PRO245; isolated PRO301 comprising residues 28-235 of the 299 residue sequence; (4) isolated PRO362 comprising residues 1-229 or 1-X (X = 271-280) of the 321 residue sequence; (5) an isolated antibody which binds PRO301 or PRO362; (6) treating an inflammatory disease by administering a therapeutically effective amount of a PRO301, PRO362 or PRO245 antagonist or fragment; determining the presence of PRO301, PRO362 or PRO245; and (7) diagnosis of an inflammatory disease or tumor, by detecting the level of PRO301, PRO362 or PRO245 gene expression. ACTIVITY : Cytostatic; Anti-inflammatory. MECHANISM OF ACTION : Antagonist.
Patent PT-1598991-E (PT)
Title: Method of and system for transmitting signals using frequency hopping
Inventor: NIELSEN MARTIN SANDAL
IPC: A63H30/04
Filed: 2002-01-03
Abstract: Method of and system for transmitting signals, e.g. control signals, request signals, intermgation signals etc. in a control system comprising at least two units, wherein at least one of said units is designed to operate as a master unit and wherein at least one of said units is designed to operate as a slave unit. A plurality of channels may be used for the transmission, a first unit performs the steps of detecting a vacant channel and transmitting a signal via said vacant channel, and at least one other unit performs the step of scanning the channels for transmitted signals. The master unit waits for a reply when having transmitted said signal, and if no reply or an erroneous reply is received said master unit proceeds with the step of detecting a vacant channel by jumping to another channel. <IMAGE>
Patent PT-1563911-E (PT)
Title: Liquid dispensing pistol provided with a dispensing position locking button
Inventor: ROMAN GIANFRANCO
IPC: B05B1/30
Filed: 2005-02-07
Abstract: A liquid spraying pistol is described, in particular for gardening, comprising an external casing (2) passed through by a channel (5) within which a valve (7) is slidingly housed which is biased by a spring (16) and is operable by a start lever (4) which is turnable between a closing position and a maximum opening position of said valve (7) and a device for the locking/unlocking of said lever (4) in maximum opening position. Said device is made up of a button (9) elastically supported by said lever (4) in such a way as to be able to provide, with the lever (4) in maximum opening position, a locking engagement between said lever (4) and the external casing (2). <IMAGE>
Patent PT-1726310-E (PT)
Title: Drug for cancer therapy
Inventor: YAMADA AKIO
IPC: A61K38/40
Filed: 2005-03-09
Abstract: A lactoferrin hydrolysate mixture or lactoferrin partial peptide that can be obtained by hydrolyzing lactoferrin with a hydrolytic enzyme and has an action of enhancing cytotoxic activity of an antibody drug in an antibody therapy of cancer is used as an active ingredient of a drug for enhancing cytotoxic activity of an antibody drug in an antibody therapy of cancer.
Patent PT-1899105-E (PT)
Title: Method for producing three-dimensionally structured surfaces and apparatus for carrying out the method
Inventor: VOGT GUNTER
IPC: B29D99/00
Filed: 2006-03-29
Abstract: In a method for producing three-dimensionally structured surfaces of objects as a reproduction of an original surface, the topology of the original surface is determined, and the data are used for controlling a machining tool. The determined topology and a random topology of a reproduction surface are brought closer to one another via a series of proximity comparisons until all items of height information of the reproduction surface are successively replaced by items of height information from the original surface, and that once an established similarity between the topologies of the reproduction surface and the original surface is obtained, the items of height information of the reproduction surface are provided for controlling the machine tool serving to machine the surface of the object.
Patent PT-1915375-E (PT)
Title: Derivatives of 5-pyridinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics
Inventor: LOCHEAD ALISTAIR
IPC: C07D471/18
Filed: 2006-08-07
Abstract: The invention relates to compounds having general formula (I), wherein R is as defined herein. The invention also relates to acid addition salt, a hydrate or a solvate of compounds of formula (I). The invention further relates to the method of preparing said compounds and to the use of same in therapeutics.
Patent PT-2087147-E (PT)
Title: Advanced non-electrolytic method for metallizing a substrate by metallic salt(s) reduction and aerosol(s) projection
Inventor: STREMSDOERFER SAMUEL
IPC: C23C18/16
Filed: 2007-11-26
Abstract: The invention relates to a non-electrolytic method for metallizing a substrate by projecting an aerosol containing a solution of an oxidant metallic cation and of a reducing agent; said method comprising a step of -a- wetting the substrate; starting to project a metallisation according to a succession of projecting phases alternating with relaxing phases: (i) by adjusting the duration Dp of the projection phases and the duration Dr of the relaxing phases from a metallisation constant k intrinsic for each metal; and (ii) by adjusting the projection flow-rate. The metallisation projection is carried out dynamically by displacing projection means relative to the substrate in order to carry out a periodical scanning, wherein Dp correspond to the duration during which the surface unit in question is submitted to the continuous projection of the aerosol and Dr corresponds to the duration during which the part is not submitted to projection.
Patent PT-2014285-E (PT)
Title: Npyy5 antagonists
Inventor: KAWANISHI YASUYUKI
IPC: A61K31/421
Filed: 2000-11-21
Abstract: Neuropeptide Y5 receptor antagonist comprises new or known aminosulfinyl or aminosulfonyl derivatives (I). Neuropeptide Y5 receptor antagonist comprises aminosulfinyl or aminosulfonyl derivatives of formula (I), their prodrugs, salts or solvates. [Image] R 1optionally substituted lower alkyl, cycloalkyl or aryl, or R 1 + R 2lower alkylene; n : 1 or 2; X : (CR 3R 4) pA(CR 5R 6) q, HetU, NR 2X or optionally substituted lower alkylene, lower alkenylene, CO-lower alkylene or CO-lower alkenylene; A : optionally substituted cycloalkylene, cycloalkenylene, bicycloalkylene, arylene or divalent heterocycle; p, q : 0 or 1; Het : piperidinediyl, piperazinediyl, pyridinediyl, pyrazinediyl, pyrrolidinediyl or pyrrolediyl all attached to NR 2 via N; U : a bond, lower alkylene or lower alkenylene; Y : OCONR 7, CONR 7, CSNR 7, NR 7CO or NR 7CS; R 2-R 7H or lower alkyl; Z : optionally substituted lower alkyl, lower alkenyl, amino, lower alkoxy, carbocyclyl or heterocyclyl. Independent claims are also included for compounds (I), their salts, prodrugs and solvates in which: (i) X = 2-6C alkylene or 3-6C alkenylene; and R 1 = optionally substituted 3-10C alkyl or 5 or 6C cycloalkyl; provided that when Y = NR 7, the Z is not lower alkylphenylamino, lower hydroxyalkylphenylamino or acylphenylamino; (ii) A = heteroarylene or optionally substituted cycloalkylene, cycloalkenylene, bicycloalkylene or piperidinylene; and R 1 = optionally substituted 3-10C alkyl or 5 or 6C cycloalkyl; and (iii) A = p-phenylene; R 1 = 3-10C alkyl or 5 or 6C cycloalkyl and Z = p-lower alkylphenylene; provided that when R 1 = isopropyl, the Z is not p-n-butylphenylene. ACTIVITY : Anorectic; antidiabetic; hypotensive; antilipemic; antiarteriosclerotic; cardiant. MECHANISM OF ACTION : Neuropeptide-Y5 antagonist. In assays, a compound of formula (Ia) exhibited IC 50 values for neuropeptide Y5 binding of 0.1 nM and for cAMP in Chinese hamster ovary cells of 1.9 nM. [Image].
Patent PT-1970614-E (PT)
Title: Hose fitting for a hose with multiple chambers
Inventor: MEISTER MARCUS
IPC: F16L11/22
Filed: 2008-01-09
Abstract: A connection system for multiple pipes (1), e.g. for irrigation, has a set of nipples (7 to 9) corresponding to the number of ducts and mounted on a plate and held inside a compression fitting. The main connector has a slit end (22) into which the multiple hose is pushed. The nipples, mounting plate and inner housing can be a one piece molding. The whole connector is secured by an outer threaded clamping sleeve (16) with a single connecting nozzle (19).
Patent PT-2425152-E (PT)
Title: Rope termination
IPC: F16G11/00
Filed: 2010-04-21
Abstract: A rope termination (10) for a rope (19) having a plurality of sub-ropes (21-32), said rope termination comprising a connection device having a load pin (12) wherein each of said plurality of sub-ropes (21-32) is spliced into itself to form a looped end, wherein said looped ends are arranged on said load pin and each of said plurality of sub-ropes (21-32) is of equal length. The connection device further comprises a connector (34) for a rope connection assembly whereby tension is equally transferred between said load pin and each of said plurality of sub-ropes.
Patent PT-739353-E (PT)
Inventor: NILSSON BJORN
IPC: C12R1/445
Filed: 1995-01-16
Abstract: Novel proteins obtainable by mutagenesis of surface-exposed amino acids of domains of natural bacterial receptors, said proteins being obtained without substantial loss of basic structure and stability of said natural bacterial receptors; proteins which have been selected from a protein library embodying a repertoire of said novel proteins; and methods for the manufacture of artificial bacterial receptor structures.
Patent PT-764177-E (PT)
Inventor: MANDEVILLE W HARRY III
IPC: A61K9/52
Filed: 1995-05-24
Abstract: A method for removing bile salts from a patient by ion exchange by administering to the patient a therapeutically effective amount of one or more highly crosslinked polymers characterized by a repeat unit having the formula    <IMAGE>  (1)  or copolymer thereof, where n is an integer; R1 is H or a C1-C8 alkyl group; M is   <IMAGE>   or -Z-R2; Z is O, NR3, S, or (CH2)m; m=0-10; R3 is H or a C1-C8 alkyl group; and R2 is   <IMAGE>   where p=0-10, and each R4, R5, and R6, independently, is H, a C1-C8 alkyl group, or an aryl group, the polymers being non-toxic and stable once ingested.
Patent PT-789793-E (PT)
Inventor: ROE DONALD CARROLL
IPC: D04H1/64
Filed: 1995-10-26
Abstract: A method of forming apertured webs is provided comprising the steps of: (a) forming a foraminous member comprising gross foramina and fine foramina wherein the gross foramina define a patterned design superimposed on the fine foramina by means of applying and curing a photosensitive resin onto a foraminous element comprising fine foramina in order to form elevated portions on the fine foramina defining the gross foramina, (b) providing a layer of fibers on said foraminous member; and (c) applying fluid streams to said layer of fibers such that the fibers are randomly entangled in regions interconnected by fibers extending between adjacent entangled regions in a pattern determined by the pattern of the gross foramina of the foraminous member to form an apertured web.
Patent PT-812235-E (PT)
Inventor: ZANNINI GAETANO
IPC: A61K9/46
Filed: 1996-07-25
Abstract: PCT No. PCT/FR96/01181 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Jul. 25, 1996 PCT Pub. No. WO97/04861 PCT Pub. Date Feb. 13, 1997A method for making solid granules containing aromatic, nutritional, dietary or cosmetic substances, wherein a core consisting of excipients optionally combined with active substances is formed for use as a carrier, and the core is coated in three steps with at least one layer, with one layer being formed in each step, by (a) coating the core with active substances optionally combined with excipients, (b) drying the layer and (c) screening the coated core. The method is preferably used to make granules that contain plant extracts and essential oils and may be chewed, sucked, swallowed or dissolved.
Patent PT-843562-E (PT)
Inventor: DACULSI GUY
IPC: A61L27/50
Filed: 1996-07-29
Abstract: PCT No. PCT/FR96/01196 Sec. 371 Date Apr. 13, 1998 Sec. 102(e) Date Apr. 13, 1998 PCT Filed Jul. 29, 1996 PCT Pub. No. WO97/05911 PCT Pub. Date Feb. 20, 1997A biomaterial composition for the resorption/substitution of organic supporting tissues, including 20-75 wt. % of an inorganic phase consisting of particles that include either hydroxyapatite (A) optionally mixed with tricalcium phosphate  beta  (B), or calcium-titaniumphosphate (Ca(Ti)4(PO4)6) (C), and 80-25 wt. % of a liquid phase including an aqueous solution of a water-soluble biocompatible polymer that is cross-linkable under the effect of the pH of the medium. The composition is sterilizable, injectable and curable in biological media to form a biomaterial for replacing supporting tissues.
Patent PT-842965-E (PT)
Inventor: DUBIEF CLAUDE
IPC: A61Q5/02
Filed: 1997-10-06
Abstract: New cosmetic and dermatological compositions (I) to prevent the discolouration of keratinous fibres comprise organosiloxane compounds R'b-Si-o (4-b)/2 (II) with UV-absorbent groups.
Patent PT-901554-E (PT)
Inventor: CITTADINI ANTONIO
IPC: E05F15/16
Filed: 1997-05-27
Abstract: This invention relates to folding blinds for windows and doors, comprising a number of horizontally articulated slats connected to each other by means of hinged joints which, when the blind is raised, enable the slats to automatically fold like an accordion inside a box. Each slat features a pin terminating with a wheel, which is engaged by the teeth of two cams whose rotation allows the raising and lowering of the blind.
Patent PT-1149448-E (PT)
Inventor: JACKY RAYON
IPC: H02B1/52
Filed: 1999-11-25
Abstract: The invention concerns a fixing accessory consisting of two separate components (22A, 22B), namely a top component (22A) adapted to be made integral with an apparatus mechanism (10), and a lower component (22B), adapted to be made integral with a wireway base, with, interposed between said two components (22A), 22B) interlocking means (23). The invention is characterised in that said interlocking means (23) are quarter turn mounting means. The invention is particularly useful for fixing an electrical apparatus mechanism on the floor of a wireway base.
Patent IE-890019-L (IE)
Title: Novel chimeric antibodies
IPC: C07K16/00
Filed: 1989-01-04
Abstract: The invention relates to murine/human chimeric monoclonal antibodies with high specificity to and affinity for human carcinoembryonic antigen (CEA), derivatives thereof, processes for the preparation of these antibodies and their derivatives, DNAs coding for heavy and light chains of these antibodies, processes for the preparation of said DNAs, mammalian cell lines that produce and secrete the antibodies and processes for the preparation of said cell lines. The chimeric antibodies and their derivatives are used for clinical purposes in vitro and in vivo, especially for the diagnosis of cancer, for localization and in vivo imaging of tumors, for therapy, e.g. site-directed delivery of cytotoxins, and similar purposes. The invention also concerns test kits and pharmaceutical compositions containing said chimeric monoclonal antibodies and/or derivatives thereof.
[EP0323806A1]
Patent IE-32844-L (IE)
Title: Hydrazino-benzocinnoline and -benzocycloheptapyridazine¹derivatives
IPC: C21C5/32
Filed: 1969-01-10
Abstract: 1,217,661. Hydrazino - benzocinnolines and benzocycloheptapyridazines. BRISTOLMYERS CO. 7 Jan., 1969 [11 Jan., 1968], No. 1033/69. Heading C2C. Novel compounds of the formula wherein X and Y are alike or different and each is H, F, Cl, Br, CF 3 , OH, C 1-6 alkyl, C 1-6 alkoxy, NH 2 or NO 2 ; and n is 1 or 2, or non-toxic, pharmaceutically acceptable acid addition salts thereof, are obtained by reacting a compound of the formula with an excess of hydrazine hydrate. The preparation of intermediates is described as follows:- 1 - Tetralone - 2 - acetic acid is refluxed with hydrazine hydrate to form 2,3,4,4a,5,6-hexahydro - 3 - oxo - benzo[h]cinnoline which is treated in glacial acetic acid with bromine to form 2,3,5,6 - tetrahydro - 3 - oxo - benzo[h] cinnoline and the latter is heated with POCl 3 to yield 5,6 - dihydro - 3 - chloro benzo[h]cinnoline. By similar methods starting from benzosuber-1- one-2-acetic acid there are obtained 2,3,4,4atetrahydro - 3 - oxo - benzocyclohepta[5,6-c] pyridazine, 2,3 - dihydro - 3 - oxobenzocyclohepta[5,6-c]pyridazine and 3-chlorobenzocyclohepta[5,6-c]pyridazine. α-Tetralone is reacted with bromoacetic acid to yield 1-tetralone-2- acetic acid. Pharmaceutical compositions having hypotensive action comprise a compound of Formula (1) above or a salt thereof as above and a pharmaceutical carrier in forms suitable for oral, parenteral or rectal administration.
[GB1217661A]
Patent IE-890093-L (IE)
Title: Process for preparing 1-hydroxyalkyl-2-methyl-5-nitroimidazoles
IPC: A61K31/415
Filed: 1989-01-13
Abstract: Process for preparing 1-(hydroxyalkyl)nitroimidazoles of formula: <IMAGE> (I)  which comprises reacting a sulphite or diacetate of an alkylenediol of formula: HO-(CH2)n-OH (II) in the presence of a strong acid (sulphuric acid) with an imidazole derivative of formula: <IMAGE> (III)  followed by hydrolizing or alcoholizing the product obtained. In the formulae (I) and (III), R denotes hydrogen or hydrocarbon. In the formulae (I) and (II), n is 2 or 3. In the formula (III), X denotes hydrogen or a radical which can be removed by hydrolysis or alcoholysis.
Patent IE-790180-L (IE)
Title: Benzopyranone oximes
IPC: A61K31/352
Filed: 1979-01-31
Abstract: A series of 2,3-dihydro-4H-1-benzopyran-4-one O-carbamoyl-oximes are useful as gastric antisecretory agents.
[US4169097A]
Patent IE-44481-L (IE)
Title: Compressed air brake.
IPC: B60T15/48
Filed: 1977-02-03
Abstract: Valve means associated with the tripple valve of a graduated release air brake for controlling the pressure in an air reservoir, particularly a control reservoir, comprising a control valve between the main brake pipe and the pressure controlled reservoir, said valve which contains a valve element operable by the brake cylinder pressure and a valve element operable by the brake pipe pressure during release controlling serially connected first and second flow openings between the main brake pipe and the reservoir that is to be controlled, characterised in that the pressure control valve further comprises a third valve element which is operable by the main brake pipe pressure when the brake is released and displaceable from an open into a closing position, and which contains a flow-restricting opening providing communication in either position of the third valve element between the main brake pipe and the pressure controlled reservoir. [IN146196A1]
Patent IE-780246-L (IE)
Title: THIAZINO [5,6-b] INDOLE DERIVATIVES
IPC: C07D513/14
Filed: 1978-02-03
Abstract: Compounds of the formula  WHEREIN R1 is hydrogen, methyl or ethyl; R2 is methyl or ethyl; Y is hydrogen, fluorine, chlorine, bromine, methoxy, methyl, ethyl or trifluoromethyl; and Ar is 2-thiazolyl which may have one or two methyl or ethyl substituents attached thereto; 5,6-dihydro-4H-cyclopentathiazol-2-yl; 4,5,6,7-tetrahydro-2-benzothiazolyl; 2-benzothiazolyl; 3-isothiazolyl which may have a methyl substituent attached thereto; 2-pyridyl which may have a methyl or hydroxyl substituent attached thereto; 3-pyridyl; 4-pyridyl; 4-pyrimidinyl; pyrazinyl; 2-benzimidazolyl; 2-oxazolyl which may have a methyl substituent attached thereto; 2-benzoxazolyl; or phenyl which may have a fluoro, chloro, bromo, methyl, ethyl, trifluoromethyl or methoxy substituent attached thereto; and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases. The compounds as well as their salts are useful as antiphlogistics and blood platelet aggregation inhibitors. (From US4137313 A) [FR2379542A1]
Patent IE-38925-L (IE)
Title: Sulphonylbenzamide derivatives
IPC: C07C315/04
Filed: 1974-02-26
Abstract: 1420540 Process for 2,5-disubstituted benzamides SOC D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE DE-FRANCE 26 Feb 1974 [28 Feb 1973] 8664/74 Heading C2C Compounds of Formula (I) are made by reacting a 2,5-disubstituted benzoic acid with carbonyl di-imidazole to give compounds of Formula (IV) (not isolated) and thereafter reacting (IV) with H 2 N(CH 2 ) n A (I may, if desired, be converted into salts; A is mono- or di-C 1-5 alkylamino, or a heterocyclic saturated ring containing N and optionally O and/or S, B is C 1-5 alkyl or alkenyl, n is 1 or 2and X is NH 2 , mono- or di-alkylamino, alkenyl or alkyl). A is, e.g. diethylamino.
[GB1420540A]
Patent IE-890453-L (IE)
Title: Printed transdermal drug delivery device
IPC: A61F/
Filed: 1989-02-13
Abstract: A method for making transdermal drug delivery devices is provided which includes: laminating an adsorbent source layer to a pressure-sensitive, pharmaceutically acceptable contact adhesive; depositing a drug in liquid form on one face of the source layer; laminating an anchor adhesive layer to the opposing face of the source layer; and applying a drug-impermeable backing layer to the anchor adhesive, which backing layer then defines the upper surface of the device. The invention also encompasses transdermal drug delivery devices having a source layer in contact with and contained between anchor and contact adhesive layers, with a backing layer adjacent the anchor adhesive defining the upper surface of the device.
Patent IE-890518-L (IE)
Title: Tetrazole excitatory amino acid receptor antagonists
IPC: A61K31/41
Filed: 1989-02-17
Abstract: The present invention provides novel tetrazole derivatives useful as excitatory amino acid receptor antagonists and in treating a variety of associated nervous system disorders.
Patent IE-780767-L (IE)
Title: Peptide complexes of desoxyribonucleic acid.
IPC: A61P31/04
Filed: 1978-04-19
Abstract: The present invention has as an aim of the peptide complexes prepared starting from organizations containing of the desoxyribonucleic acid. [FR2387991A1]
Patent IE-37682-L (IE)
Title: Cheese mould
IPC: A01J25/13
Filed: 1973-05-24
Abstract: Rectangular, large cheese mould, consisting of a box-like body and wherein the space intended for the cheese is confined by side strainer plates and bottom strainer plates, and wherein one end of the mould has been constructed to constitute a door, through which the bottom strainer plates and the cheese bolster resting on these may be extracted from the mould. The side strainer plates are connected with the body by the aid of guiding means which force the side strainer plates to move away from the cheese bolster immediately when one commences to withdraw the latter from the mould.
[US3873256A]