Patent GB-689961-A (GB)
Title: Process for the manufacture of therapeutic compositions
IPC: A61K31/63
Filed: 1948-02-27
Abstract: A composition having a bactericidal and vaso-constrictive action is made by interacting an aqueous solution of a calcium compound of a sulphanilamide having antibacterial action and a vaso-constrictive amine.  The composition may be stabilized by adding a small proportion of a highly soluble calcium salt, e.g. calcium chloride, bromide or saccharate.  Sulphanilamides specified are sulphathiazole, sulphadiazine, sulphamerazine and sulphanilamide itself, and these may be used in amount to give a 1 to 5 per cent solution of the calcium compound.  Suitable vaso-constrictive amines are ephedrine, desoxyephedrine and adrenaline to give a 0.1 to 0.2 per cent solution.  In an example, a composition is prepared containing 2 per cent of calcium sulphathiazole, 0.033 per cent of calcium chloride and 0.2 per cent of desoxyephedrine.  The Specification as open to inspection under Sect. 91 comprises also a process for the manufacture of metal compounds of sulphanilamides by reacting a p-aminobenzenesulphonamide having a free hydrogen attached to the nitrogen of the sulphonamide group with a metal compound under anhydrous conditions.  Calcium salts of sulphanilamides are made by reacting a p-aminobenzenesulphonamide with the calcium compound of a lower aliphatic alcohol, and the calcium salt may then be precipitated from solution by adding a miscible anhydrous organic liquid in which the calcium salt is insoluble, e.g. chloroform. Non-alkali metal compounds of sulphanilamides are made by double decomposition between a suspension or solution of the alkali metal salt of the sulphanilamide and a compound of the non-alkali metal. Examples are given of the preparation of (1) calcium sulphathiazole, (2) calcium sulphapyridine, (3) calcium sulphanilamide, (4) antimony sulphathiazole, (5) silver sulphathiazole, (6) manganese sulphathiazole, (7) mercury sulphathiazole, (8) sodium sulphanilamide, (9) sodium sulphathiazole, (10) sodium sulphapyridine, (11) calcium sulphathiazole through the sodium compound, (12) tin sulphathiazole, (13) sulphathiazole bismuthate from sodium sulphathiazole and sodium bismuthate, (14) sulphathiazole antimonite from sodium sulphathiazole and sodium antimonite, (15) sulphathiazole stannite from sodium sulphathiazole and sodium stannite.  This subject-matter does not appear in the Specification as accepted.  Reference has been directed by the Comptroller to Specification 595,592.ALSO:A composition having a bactericidal and vaso-constrictive action is made by interacting an aqueous solution of a calcium compound of a sulphanilamide having antibiotic action and a vaso-constrictive amine.  The composition may be stabilized by adding a small proportion of a highly soluble calcium salt, e.g., p calcium chloride, bromide or saccharate.  Sulphanilamides specified are sulphathiazole, sulphadiazine, sulphamerazine and sulphanilamide itself, and these may be used in amount to give a 1 to 5 per cent solution of the calcium compound.  Suitable vaso-constrictive amines are ephedrine, desoxyephedrine and adrenaline to give a 0.1 to 0.2 per cent solution.  In an Example, a composition is prepared containing 2 per cent of calcium sulphathiazole, 0.033 per cent of calcium chloride and 0.2 per cent of desoxyephedrine.  Reference has been directed by the Comptroller to Specification 595,592.