baber/WOPTO huggingface dataset:
Patent CA-2859127-A1 (CA)
Title: Novel oligonucleotide conjugates and use thereof
Inventor: CHAE JEIWOOK
IPC: C12N15/11
Filed: 2012-12-14
Abstract: The present invention provides a double-stranded RNA  structure, which comprises a polymer compound covalently bonded to a double-helix oligo RNA useful for the treatment of diseases, particularly cancer, in order to enhance the delivery of the double-helix oligo RNA, and further comprises a target-specific ligand bonded thereto, a preparation method thereof, and a technique of delivering the double-helix oligo RNA in a target-specific manner using the RNA structure. A  nanoparticle composed of the ligand-bonded double-helix oligo RNA structures can efficiently deliver the double-helix oligo RNA to a target, and thus can exhibit the activity of the double-helix oligo RNA even when the double-helix oligo RNA  is administered at a relatively low concentration. Also, it can prevent the non-specific delivery of the double-helix oligo RNA into other organs and cells. Accordingly, the ligand-bonded double-stranded RNA structure can be used for the treatment for various diseases, particularly cancer, and can also be effectively used as a new type of double-helix oligo RNA delivery system. Particularly, the ligand-bonded double-stranded RNA structure can be effectively used for the treatment of diseases, including cancer and infectious diseases. Moreover, the present invention relates to a hybrid conjugate, which comprises a hydrophilic material and hydrophobic material bonded to both ends of an antisense oligonucleotide (ASO) by a covalent bond in order to enhance the in vivo stability of the ASO, a method for preparing the hybrid conjugate, and a nanoparticle composed of the conjugates. The ASO-polymer conjugate according to the invention can increase the in vivo stability of the ASO, making it possible to efficiently deliver the therapeutic ASO  into cells. Also, the ASO-polymer conjugate can exhibit the activity of the ASO even when it is administered at a relatively low concentration.
Patent CA-2859237-A1 (CA)
Title: Modular system
Inventor: NIELSEN JORGEN
IPC: A47B87/02
Filed: 2012-12-12
Abstract: Modular system (2) comprising at least two modules (1), said modules comprising a shelf top panel (3) and an oppositely placed shelf bottom panel (4), said two panels being mutually connected by a first shelf side panel (5) and an oppositely placed second shelf side panel (6) for providing a box-shaped module (1). Said module (1) comprises positioning means 89) adapted to position one module (1) to a second module (1), and the modular system (2) also comprises at least one extension panel (8), said extension panel (8) comprising fastening means adapted to engage with the positioning means, whereby the extension panel is secured.
Patent CA-2859488-A1 (CA)
Inventor: FARRELL MARK
IPC: H01T13/34
Filed: 2014-08-15
Abstract: The plug comprises a nut, a coupling extending from the nut and adapted to receive an ignition wire and an insulator extending from the nut and away from the coupling. A  positive electrode extends through the insulator. An externally-threaded tubular portion extends from the nut in surrounding relation to the insulator and terminating, short of the insulator end, in a cap that is disposed in spaced relation to the insulator.  The cap defines a void having: a central portion into which the positive electrode extends; an annular channel surrounding the central portion; and a plurality of lobes, each positioned with respect to the central portion as the planet gears are positioned with respect to the sun gear in a planetary gear. The cap has a central surface that is axially spaced from the insulator and a convex surface that surrounds and extends to the central surface.
Patent CA-2860738-A1 (CA)
Inventor: JONES PETE
IPC: B44C3/00
Filed: 2014-08-27
Abstract: Des systèmes, des méthodes et des supports lisibles par ordinateur pour la génération de produits commémoratifs au moyen dun système de conception et de commande de produits commémoratifs (le système de conception). Le système de conception peut généralement être configuré pour fournir à des utilisateurs une plateforme, des outils, des éléments de conception, des procédés automatisés, etc. pour la conception, la personnalisation et la commande de produits commémoratifs. Le système peut être configuré pour présenter à des utilisateurs des représentations graphiques ou virtuelles dobjets commémoratifs physiques (des modèles de produits virtuels) pouvant être personnalisés en précisant des caractéristiques de produit et en ajoutant divers éléments de conception. Selon certains modes de réalisation, les modèles de produits virtuels peuvent être et/ou comprendre des représentations photoréalistes et/ou tridimensionnelles des produits commémoratifs physiques réels. De cette façon, le système de conception peut être configuré pour fournir à un client une expérience utilisateur réaliste au moyen dun outil de conception virtuel et/ou en ligne.
Patent CA-2862278-A1 (CA)
Inventor: KISHIMOTO MAKOTO
IPC: A61F9/007
Filed: 2012-04-18
Abstract: [Problem] Provided are: a fragmentation tip able to suppress the occurrence of cavitation; an intraocular surgery device; a method for suppressing the occurrence of cavitation; and a cataract surgery method. [Solution] The fragmentation tip is attached to an intraocular surgery device that imparts ultrasonic vibrations, and is provided with: a tubular support section mounted to the intraocular surgery device; and a tubular tip main body that is provided to the tip of the support section and that interconnects with the inner space of the support section. The tip main body has a cross-sectional shape such that the length in a first direction is longer than the length in a second direction perpendicular thereto. Vibrations are imparted to the support section in a manner so that the tip main body reciprocally rotates around the axial line of the tip main body passing through the center in the first direction and second direction.
Patent CA-2864553-A1 (CA)
Inventor: SPENCINER DAVID B
IPC: A61B17/04
Filed: 2014-09-22
Abstract: A graft retention device has an elongated body with first and a second ends, and a midpoint therebetween. A pair of elongated slots through the body defines a tang therebetween. At least one of the slots have an open first end into the body at the body first end such that the first end is closed via a retention line between the tang and the body. A graft retention loop disposed over the tang is slidable therealong from a first position closer to the body first end and a second position closer to the midpoint.
Patent CA-2865188-A1 (CA)
Inventor: MEUWISSEN DIRK
IPC: E01C11/08
Filed: 2013-02-27
Abstract: The present invention relates to a expansion joint to bridge an expansion gap between two parts of concrete slabs used in floor construction, especially in the manufacture of concrete floors such as for example in industrial floors. The expansion joint has an upper (2) and lower (3) portion, wherein the upper portion provides a dividing member (4) and the lower portion comprises a vertically oriented corrugated plate (5). In a further embodiment of the present invention, the expansion joint is characterized in having an upper (2) and lower (3) portion, each comprising two vertically oriented corrugated plates with undulations that fit in one another, and characterized in that the corrugated plates of the upper and lower portion are out of phase to one another.
Patent CA-2865590-A1 (CA)
Title: Automated beverage dispensing system with cup lidding and beverage identification
Inventor: PICKETT SEAN
IPC: B67D1/08
Filed: 2013-02-27
Abstract: The present application provides an automated beverage dispenser (100) using a number of cups and a number of lids. The automated beverage dispenser may include a lid stack (450) with the number of lids, a lidding mechanism (480), and a positioning device (565) for maneuvering the lidding mechanism so as to remove one of the number of lids from the lid stack and to attach the lid to one of the number of cups.
Patent CA-2865788-A1 (CA)
Title: Apparatus and method for providing a stretched and optionally crystallized neck finish in a molded plastic article
Inventor: BARKER KEITH
IPC: B29B11/00
Filed: 2007-09-05
Abstract: An apparatus for treating a series of molded plastic articles is described which includes a series of platforms, each having a top surface and a mating mechanism for engaging the body portion of an article, carried by a conveying apparatus that transports the platforms along a predetermined path of travel through a finish widening station. The top surface engages a bottom surface and the mating mechanism engages a sidewall surface of the body portion of the article. A mandrel is insertable within and removable from an open top aperture of the finish portion to widen the finish portion, and includes a lower tapered body portion insertable into the open top aperture for widening the neck finish portion from a first neck size to an expanded second neck size. The mandrel includes a cooled upper body portion of the second expanded neck size for cooling the expanded neck finish portion.
Patent CA-2866067-A1 (CA)
Inventor: KALAYOGLU MURAT V
IPC: A61P3/10
Filed: 2012-01-18
Abstract: Provided are uses of certain F-series prostaglandin compounds of the Formula (I-h): (see formula I-h) and acceptable salts thereof, for treatment of diabetes and dyslipidernia, wherein ~ , L, R1, R2, R3, R3', X, Y , x, y and n are defined herein.
Patent CA-2866231-A1 (CA)
Inventor: THOMPSON WILLIAM
IPC: C07D211/26
Filed: 2013-03-13
Abstract: The present invention relates to derivatives of compounds which are known to be of use in the field of agriculture. These derivatives are differentiated from the parent active compound by virtue of being redox derivatives of the active compound. This means that one or more of the functional groups in the active compound has been converted to another group in one or more changes one or more of which may be considered to represent a change of oxidation state relative to the groups in the original compound. We refer to these compounds generally as redox derivatives. The compounds are of use as insecticides, herbicides and insect repellents.
Patent CA-2866613-A1 (CA)
Title: Multi-protocol routing system and method driven by integration of applications and networks
Inventor: WANG JINLIN
IPC: H04L45/02
Filed: 2013-01-07
Abstract: The present invention relates to a multi-protocol routing system, comprising a route determining module and a forwarding module which are located in network layer, wherein the route determining module is used for determining, based on the related information of applications and networks, the types of routable protocols and the next-hop path which are to be selected in the current routing phase; the forwarding module, including different routable protocols and corresponding routing information, is used for periodically calculating the newest remaining network resources and the state of link during a routing process and updating the forwarding table in current state. By integrating various characteristics and states of applications as well as different routable protocols, the present invention realizes real-time protocol selection and dynamic routing. Moreover, the present invention is easy to be expanded to other protocols, thus being adaptive to the continuous development and evolution of network services.
Patent CA-2868030-A1 (CA)
Inventor: DEROSA FRANK
IPC: C12N15/88
Filed: 2013-03-29
Abstract: Disclosed herein are novel lipids and liposomal compositions prepared using such compounds and related methods of neutralizing or otherwise modifying such liposomal compositions. The lipids described herein are useful for example, as liposomal vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and the subsequent transfection of such target cells. In certain embodiments, one or more of the compounds that comprise the liposomal delivery vehicle may be neutralized or further modified such that the properties of the liposomal delivery vehicle are modified.
Patent CA-2868433-A1 (CA)
Title: Mining elevator carrying platform and carrying method
Inventor: CAO GUOHUA
IPC: B66B17/18
Filed: 2013-03-25
Abstract: A mining elevator carrying platform and carrying method, the platform comprises a power system (1) and a four-rod carrying device (5), a rotating rod (3) connected with the power system (1) is set on the carrying device (5); the power system (1) comprises a flameproof motor (1-1), a upper-limited switch (1-2), a down-limited switch (1-5) and a main pulley (1-6), the flameproof motor (1-1) is connected with the main pulley (1-6) through a main steel cable (1-4), a baffle (1-3) is set on the main steel cable (1-4), a double cable channel is set on the main pulley (1-6), and the main pulley (1-6) is connected with a sub-pulley (1-8) by a sub-steel cable (1-7), a sliding plate (1-9) is set on the sub-steel cable (1-7), and a sliding rod (1-10) is set on the sliding plate (1-9). The main pulley (1-6) is driven to rotate by the flameproof motor (1-1) through the main steel cable (1-4), thus the sub-pulley (1-8) is driven to rotate. The sliding rod (1-10) moves in a strip-opening sliding slot in the rotating rod (3) by the sliding plate (1-9) moving up and down, then the rotating rod (3) and a carrying plate (5-1) are driven to move circumferentially. A rocker (5-3) is rotated around a supporting bracket (5-4) driven by a connecting rod (5-2), thus a credible carrying platform in multi-plane is realized. The platform is simple in structure, controlled accurately, convenient to be fixed and maintained, operated stably and reliably, and has the self-locking function.
Patent CA-2869093-A1 (CA)
Inventor: BAIRD LANCE AWENDER
IPC: B01D45/18
Filed: 2013-05-06
Abstract: Processes and apparatuses for converting a feedstock are provided. In one embodiment, a process of converting biomass includes flowing the biomass and a gas through a process unit. A default value is provided for a frequency of measuring a process condition in the process unit. The process condition is measured according to the frequency to obtain process condition measurements. The process condition measurements are evaluated to assess the stability of the process condition. Then, it is determined whether to change the default value depending on the stability of the process condition.
Patent CA-2869343-A1 (CA)
Title: Inflatable surfing apparatus and method
Inventor: VICENTE ORIOL A
IPC: A63B69/00
Filed: 2014-10-30
Abstract: A water or other amusement attraction that includes an inflatable portion or material. A cavity of the attraction is located underneath an upper surface, the upper surface configured to support a flow of water and at least one rider thereon. A volume of water is configured to be disposed within the cavity, the upper surface floating upon the volume of water while connected to at least one side wall, floor, and/or nozzle structure. A pump and nozzle assembly, positioned outside of the cavity, communicates with the water within the cavity for flowing a portion of the water over the upper surface. A drainage portion, adjacent to the upper surface, drains the flowing water back into the cavity for recirculation. Support components, such as a plurality of beams or an inflatable grid structure help maintain stability for the attraction.
Patent CA-2870019-A1 (CA)
Inventor: TAVARES FRANCIS XAVIER
IPC: C07D487/14
Filed: 2013-04-24
Abstract: Methods for the synthesis of lactams are presented whereby a carboxylic acid of the formula HOOC------OR---NH-LG, wherein OR is an organic moiety and LG is a leaving group, is reacted with an acid, such as an organic acid, in particular a strong acid, and a dehydrating agent, which may be one in the same such as a strong acid anhydride, such that the amount of acid added allows for the desired transformation to take place without the loss of the leaving group (LG) before the cyclization, and recovering the lactam.
Patent CA-2870702-A1 (CA)
Title: Capture reactions
Inventor: UMBARGER MARK
IPC: C12Q1/68
Filed: 2013-04-15
Abstract: The invention generally relates to methods of performing a capture reaction. In certain embodiments, the method involves obtaining a nucleic acid, fragmenting the nucleic acid, and capturing a target sequence on the nucleic acid fragment using a capture moiety, such as a molecular inversion probe.
Patent CA-2874901-A1 (CA)
Inventor: BOGREN JOHANNES
IPC: D21C3/02
Filed: 2013-05-28
Abstract: The present document relates to processes for manufacturing pulp and more specifically to improved processes for manufacturing dissolving pulp. The processes have primarily been developed to be used in connection with large scale kraft processes, i.e. they have been designed to be incorporated into a plant. A liquor derivable from the process and comprising xylan, lignin, alkali and water is also disclosed as well as a dissolving pulp produced by the process.
Patent CA-2878429-A1 (CA)
Inventor: BURNSIDE WALTER D
IPC: H01Q7/00
Filed: 2013-03-22
Abstract: In combination, an RFID antenna array, an RFID tag reader, and a power supply, the foregoing components being adapted to be worn or otherwise borne by a person and be operatively connected so that the power supply powers the reader and the reader energizes the antenna array and receives RFID tag signals through the antenna array while the person passes through an area as the person' s hands and arms are unencumbered by said components.
Patent CA-2880654-A1 (CA)
Inventor: GOODHART LESLE MARIE
IPC: A61K8/00
Filed: 2001-06-14
Abstract: A peroxide product is provided. The peroxide product includes a package having a headspace, a substrate disposed within the package, and a thin layer of a composition having a peroxide active and a polyol, wherein the thin layer is disposed adjacent the substrate. The peroxide product also includes at least one means for increasing the stability of the peroxide active of the composition.  The thin layer of the composition has at least about 43 % of its original concentration of the peroxide active at twelve months after manufacture when stored at about °C and in the absence of light.
Patent CA-2880808-A1 (CA)
Inventor: JEFFS ROGER
IPC: A61K35/28
Filed: 2013-07-30
Abstract: The application is directed to a method for treating or preventing vasculopathy comprising administrating to a subject in need thereof a pharmaceutical composition comprising mesenchymal precursor cells (MPCs) and a prostacyclin. Also provided a method for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.
Patent CA-2882867-A1 (CA)
Inventor: LAIB DOUGLAS
IPC: B65D23/10
Filed: 2013-09-19
Abstract: A container (12, 312, 412, 512, 712, 812, 912) may include a neck (20, 320, 820, 920) including an external surface (24, 324) and at least one handle retention feature (30, 330, 430, 530) with upper handle retention, surfaces (33, 35, 333, 335) A handle (14, 114, 214, 314. 414, 514, 614, 714, 814, 914) for a container may include a collar (40, 240, 340, 440, 540, 640,740, 840a-b, 940a-b) including spaced apart container retention features having axially lower and upper container retention surfaces (58, 60) to cooperate with the corresponding handle retention feature of the container to prevent axial movement of the collar with respect to the container.
Patent CA-2883402-A1 (CA)
Inventor: HUANG DAVID
IPC: A61B3/10
Filed: 2013-09-10
Abstract: Impaired intraocular blood flow within vascular beds in the human eye are associated with certain ocular diseases including, for example, glaucoma, diabetic retinopathy and age-related macular degeneration. A reliable method to quantify blood flow in one or more of the various intraocular vascular beds could provide insight into the vascular component of ocular disease pathophysiology. Using ultrahigh-speed optical coherence tomography (OCT), a new 3D angiography algorithm called split-spectrum amplitude-decorrelation angiography (SSADA) was developed for imaging microcirculation within different intraocular regions including, for example, the ocular disc, the temporal ellipse, the peripapillary retina, the peripapillary choroid, the macular retina, the macular choroid, the fovea avascular zone, and the area of non-perfusion. As described herein, a method to quantify SSADA results was developed and used to detect perfusion changes in early stage ocular disease. Associated embodiments relating to methods for quantitatively measuring blood flow at various intraocular vasculature sites, systems for practicing such methods, and use of such methods and systems for diagnosing certain ocular diseases are herein described.
Patent CA-2884104-A1 (CA)
Inventor: MIHARA AKIHIRO
IPC: H04N7/15
Filed: 2013-09-11
Abstract: A communication server includes a terminal management unit managing data identifying each of a plurality of communication terminals in association with group identification data identifying a group to which the communication terminals belong; a determination unit determining, when a session for transmitting and receiving content data is established between first and second communication terminals, whether group identification information sets of the first and the second communication terminals associated with the session are the same as each other based on the group identification data; and a report unit reporting, when the group identification information sets of the first and the second communication terminals are the same as each other, shared location information indicating a location of a shared memory area shared between the first and the second communication terminals to the first and the second communication terminals associated with the session while the session is being established.
Patent CA-2884392-A1 (CA)
Inventor: BUCKINGHAM ROBERT
IPC: F16K15/14
Filed: 2014-05-13
Abstract: A regulating apparatus for a pressure activated one-way valve. The one-way valve is for mounting on a container to permit the release of gas from within the container and to control the ingress of atmospheric air/. The regulating apparatus comprises a sealed and expandable chamber containing a gas. The chamber is operatively associated with the one-way valve such that when the chamber is exposed to elevated temperatures and/or reduced external pressure the gas within the chamber expands and exerts a force upon the one-way valve or portions thereof. The force tends to maintain the one-way valve in a closed or semi-closed configuration.
Patent CA-2884993-A1 (CA)
Inventor: CULP LESTER CARL MURRAY
IPC: E04H12/34
Filed: 2015-03-16
Abstract: A pole guide tool via which forces can be applied to a suspended pole by manipulating the tool from at least a partially spaced location from the pole.
Patent CA-2888411-A1 (CA)
Inventor: FREIER KATRIN
IPC: F41H1/02
Filed: 2013-10-15
Abstract: The invention relates to ballistic underwear. The base area of the underwear is composed of shrapnel-resistant UHMWPE knitwear 1 and at least one other, different textile material 2, 200, 14. The UHMWPE knitwear is arranged in a first zone of the base area.
Patent CA-2890427-A1 (CA)
Title: Anticorps diriges contre des determinants de surface de s. aureus
Inventor: SELLMAN BRET
IPC: A61K39/40
Filed: 2013-11-06
Abstract: L'invention concerne des anticorps et des fragments de liaison à un antigène de ceux-ci dirigés contre des antigènes de déterminant de surface de Staphylococcus aureus (S. aureus) et des toxines secrétées. L'invention concerne également des procédés de détection, de diagnostic et de traitement de S. aureus à l'aide des anticorps et des fragments de liaison à un antigène de ceux-ci.