baber/WOPTO huggingface dataset:
Patent AT-E206251-T1 (AT)
Inventor: HILLMER HARTMUT
IPC: H01S5/06
Filed: 1998-10-21
Granted: 2001-10-15
Abstract: A method and device for tuning the wavelength of an optoelectronic component arrangement including at least two optoelectronic components. The characteristic wavelength for each optoelectronic component is adjusted using a respective resistance device which is connected between a common voltage/power source and a respective heating device associated with each optoelectronic component. Heating capacity is modified by changing the overall resistance of the respective resistance device (RM) in order to adjust wavelength. The wavelength of semiconductor lasers, filters, wavelength multiplexers and waveguides may be tuned.
Patent AT-E255543-T1 (AT)
Inventor: NELSON DOUGLAS
IPC: C03C17/34
Filed: 1999-08-11
Granted: 2003-12-15
Abstract: A thin film stack applied onto a surface of a glass substrate. The thin film stack includes an iridescence-suppressing interlayer and an anti-reflective thin film stack applied over the iridescence-suppressing interlayer. The resulting coated glass article exhibits a low total reflectance and an aesthetically neutral color in reflectance from the film side.
Patent AT-E235970-T1 (AT)
Inventor: SANCHEZ DE LEON RODRIGUEZ RODA
IPC: B07C5/18
Filed: 1999-09-08
Granted: 2003-04-15
Abstract: The purpose of the invention is a fruit and vegetable conveyor for classification by weight and electro-optical parameters, of the monorail type, with the fruit-carrying elements coupled to a transporting chain formed by turning biconic rollers.  Each carrier is composed of two bicones (1) joined by a frame (2), and the set is embedded in a transporting chain (3) by means of an anchoring part (4) with two projections (5) which is able to be vertically displaced.  As the frame (2) slides along the guides, these transmit the weight to charge cells the signal of which is electronically analyzed to discount the tare and obtain the weight of each piece of fruit.  The bicones (1) turn due to friction of their polished ends against a motor belt, and the speed and turning direction of the bicones (1) depend on the relation between the lineal speeds of the motor belt and the transporting chain (3).  <IMAGE>
Patent AT-E254744-T1 (AT)
Inventor: SVENSSON ANDERS
IPC: F24F1/01
Filed: 1999-08-23
Granted: 2003-12-15
Abstract: Ventilation apparatus (10) having a room-air cooling and/or heating function and comprising a high velocity device (11) for mixed ventilation, a low velocity device (12) for displaced ventilation connected to said device (11), and valve means (20) for guiding the air flow either to the high velocity device (11) or to the low velocity device (12). The apparatus includes an ejector part (13) for receiving warm or cold supply air as primary air. The ejector part (13) includes means (17) for sucking room air into the ejector part (13) as secondary air, by means of said primary air, such that a mixture of primary and secondary air will be delivered therefrom as primary air either to the high velocity device (11) or to the low velocity device (12), depending on the setting of the valve means (20). The high velocity device (11), the low velocity device (12) and the ejector part (13) may be combined to form a single unit, with the ejector part (13) placed uppermost and the low velocity device (12) placed lowermost. The high velocity device (11) will preferably be provided with nozzles (16) for distributing the supply/room-air mixture in the room space. <IMAGE>
Patent AT-E211547-T1 (AT)
Inventor: COTTERILL RONALD IAN
IPC: G01N3/56
Filed: 1999-01-18
Granted: 2002-01-15
Abstract: Apparatus 10 (FIG. 1), for testing samples of friction material 31, 32 in rubbing contact with a surface 33 of a rubbing element 34, comprises a table 12 for supporting the rubbing element and a load cell 16 for sensing the load imposed by the frictionally coupled rotating samples from which the coefficient of friction can be determined. To make the tests repeatable rapidly and with identical starting conditions cooling means 40 is interposed between the rubbing element and table. Cooling means 40 comprises a fluid cooled heat exchanger 41, conveniently cooled by local main supply water supplied at its natural temperature, and thermoelectric cooling means 75. The thermoelectric cooling means consists of an array of planar peltier cooling elements which develops a temperature gradient there across which, with reference to the heat exchanger temperature, is able to cool and re-cool the rubbing element to temperatures as low as -25° C. within a matter of minutes. To ensure the friction material and rubbing element are not contaminated by water condensed from the atmosphere an enclosure 60 is formed around them and kept at positive pressure by dry, inert argon gas.
Patent AT-E324132-T1 (AT)
Inventor: JEWETT WARREN R
IPC: A61M11/02
Filed: 1999-02-03
Granted: 2006-05-15
Abstract: A metered dose inhaler pump for delivering a metered dose of an active compound from an active compound inlet through a spray outlet without the need of a pressurized active compound container. Reciprocating action of an inlet valve, an outlet valve and a plunger alternately draw a metered dose of the active compound from an active compound container into an active compound chamber and pressurize the drawn metered dose of the active compound to eject the metered dose through the spray outlet. The plunger substantially fills and evacuates the metered dose chamber, leaving no void head space therein.
Patent AT-E419013-T1 (AT)
Inventor: SORIANO PHILIPPE
IPC: A01K67/027
Filed: 1999-04-14
Granted: 2009-01-15
Abstract: Transgenic non-human animals one having a general deletor construct and a second having a general reporter construct are described. The general deletor animals express a heterologous recombinase under the control of an ubiquitously expressed endogenous promoter. Specifically, the Cre recombinase is inserted into the ROSA26 locus of the mouse. The general reporter animals have a gene which is desired to remove flanked by sites recognized by the is heterologous recombinase. This flanked sequence is operatively associated with a marker gene such that when the gene sequence flanked by sites recognized by the heterologous recombinase is excised, the reporter gene is expressed. When the general deletor mouse is crossed with the general reporter mouse the heterologous recombinase is expressed in essentially all cells of the resultant descendants under the control of the ubiquitous promoter. Expression of the recombinase results in the excision of the desired gene in essentially all cells of the descendant animals. A conditional deletor construct and its use to derive a conditional deletor animal are also described.
Patent AT-E431850-T1 (AT)
Inventor: TAKAGI TSUTOMU
IPC: C07K14/47
Filed: 1999-05-20
Granted: 2009-06-15
Abstract: The present invention relates to a method for screening and identifying therapeutic agents or preventive agents for central nervous system diseases which comprises assaying a suppressing effect of a test substance on an expression of a splicing variant transcribed from presenilin-2 gene and to a method for examining central nervous system diseases which comprises detecting an expression of a splicing variant transcribed from presenilin-2 gene in a test sample originated from an animal individual.  <IMAGE>
Patent AT-E418094-T1 (AT)
Inventor: HILL RONNIE
IPC: B09C1/06
Filed: 1999-06-28
Granted: 2009-01-15
Abstract: The present invention is an improved apparatus and method for its use in the decontamination and remediation of soils laden with organic hydrocarbons and toxic inorganic compounds. The soil to be treated is placed in a soil treatment tray which is subsequently placed within the treatment chamber. A multiple radiant heater rack is placed over the treatment chamber and the contaminant compounds are heated and vaporized. A blower fan creates a vacuum which pulls the organic hydrocarbon gases and other vaporized contaminants through the soil and out to the contaminant vapor removal/condenser unit where the compounds are liquified and containerized. A novel automatic safeguard system insures that all burners and fans are running continuously and automatically shuts down one or more components of the system should a burner or fan malfunction so that the potentially dangerous accumulation of explosive gasses is prevented.
Patent AT-E304886-T1 (AT)
Inventor: COCHRAN ROBERT
IPC: C07D263/20
Filed: 1999-07-07
Granted: 2005-10-15
Abstract: The present invention involves a method of treating an ophthalmic infection in a useful warm blooded mammal who is in need of such treatment which comprises topical administration of an ophthalmologically effective amount of an OXAZOLIDINONE.
Patent AT-E279983-T1 (AT)
Inventor: RYU J YONG
IPC: C07C69/96
Filed: 1999-08-10
Granted: 2004-11-15
Abstract: A process for producing dialkyl carbonates, such as dimethyl carbonate, from the reaction of a primary alcohol with urea in the presence of a novel organotin catalyst complex with a high boiling electron donor compound acting as solvent which are <DEL-S DATE="20010821" ID="DEL-S-00001">(1) materials having the general formula RO[CH2(CH2)kCH2O]mR, wherein each R is independently selected from C1-12 alkyl, alkaryl or aralkyl moieties, k=0,1, 2 or 3 and m=1, 2, 3, 4 or 5 and (2)<DEL-E ID="DEL-S-00001">  bidentate ligand which form 1:1 bidentate and/or 1:2 monodentate adducts with R'2SnX2(X=Cl, R'O, R'COO or R'COS), R'3SnX, R'SnO, Ph3-nR'SnXn or Ph4-nSnXn (wherein R'=CqH2q-1n=0, 1 or 2 and q=<DEL-S DATE="20010821" ID="DEL-S-00002">2<DEL-E ID="DEL-S-00002">  <INS-S DATE="20010821" ID="INS-S-00001">1 <INS-E ID="INS-S-00001">to 12) and mixtures thereof<INS-S DATE="20010821" ID="INS-S-00002">, such as materials having the general formula RO[CH2(CH2)xCH2O]mR, wherein each R is independently selected from C1-12 alkyl, alkaryl or aralkyl moieties, k=0,1, 2 or 3 and m=1, 2, 3, 4, or 5<INS-E ID="INS-S-00002">.
Patent AT-E294315-T1 (AT)
Inventor: LUNDBLAD LEIF
IPC: E05G1/00
Filed: 1999-11-30
Granted: 2005-05-15
Abstract: A safe for valuable documents having a shell protection around the safe for impeding attempts to force an entry thereinto and processor unit actuated in response to damage to the shell protection to initiate a safe protection function. The safe contains a plurality of units for accommodating documents, at least one of which includes a portable safe deposit box that, when placed in the safe, can be electrically connected thereto. The safe deposit box has a protective shell and a destructive device designed to effect local destruction of documents contained in the box. The destructive device operates automatically in response to damage to the protective shell when the safe deposit box is removed from the safe and an attempt is made to force the box open. However, when the safe deposit box is placed in and electrically connected to the safe, the destructive device operates in response to actuation of the processor unit such that the protective function of the box is then subordinated to the safe protection function.
Patent AT-E275025-T1 (AT)
Inventor: LUTZ HERBERT
IPC: B25C3/00
Filed: 1999-12-23
Granted: 2004-09-15
Abstract: The invention relates to a handling device for guiding pin-like fixing elements such as nails, hooks, screws or such like, comprising two half-elements (10, 20) which in a working position are arranged next to each other along a separating plane (30). The first half-element (10) has a first locating face (130) which in the working position coincides with the separating plane (30) and presents at least one first continuous recess (11, 12, 13). The second half-element (20) has a second locating face (230) which in the working position coincides with the separating plane (30) and adjoins the first locating face (130) and which presents at least one second continuous recess (21, 22, 23). In the working position each one of the first recesses (11, 12, 13) complements a respective second recess (21, 22, 23) in such a way that a continuous guide hole (1121, 1222, 1323) for the pin-like fixing element is formed. The axis of the guide hole (1121, 1222, 1323) is substantially parallel to the separating plane (30) or situated in said separating plane (30) and the half-elements (10, 20) and their respective locating faces can be moved from the working position into a release position such that the guide hole (1121, 1222, 1323) is opened.
Patent AT-E235274-T1 (AT)
Inventor: BISSON JEAN-LOUIS
IPC: A61L27/48
Filed: 1999-11-18
Granted: 2003-04-15
Abstract: The invention concerns a composition comprising: porous microparticles whereof the pore diameter excludes the penetration of cellular components having a molecular weight more than 1000 kilodaltons; and a biocompatible suspending agent. The invention also concerns the use of said composition for making a histocompatible heterologous implant.
Patent DE-04009653-T1 (DE)
Inventor: SCHULTZ PETER G
IPC: G01R33/16
Filed: 1995-10-18
Abstract: Combinatorial synthesis is done by using a substrate having an array of diverse materials thereon prepared by delivering components to predefined regions on a substrate and simultaneously reacting the components to form at least two materials. Materials that can be prepared using these methods are covalent network solids, ionic solids and molecular solids. Examples are inorganic, organometallic, intermetallic, ceramic, organic polymeric and composite materials. Once prepared, these materials can be screened for useful properties. Thus, the present invention provides for the parallel synthesis and analysis of novel material having useful properties
Patent DE-07025195-T1 (DE)
Title: Nukleotidsequenzen des Genoms von Retroviren des Typs HIV-1, HIV-2 und SIV und deren Anwendungen, insbesondere zur Amplifikation von Genomen dieser Retroviren und für die In-Vitro-Diagnostik von durch diese Viren ausgelösten Infektionen
Inventor: MONCANY MAURICE
IPC: C12Q1/70
Filed: 1990-06-05
Abstract: Oligonukleotid,
dadurch gekennzeichnet, dass dessen Sequenz besteht aus:  i)
einer spezifischen Sequenz des Gens gag und das geeignet ist, bei
einer Temperatur von 60°C ± 1°C mit den
Genomen der Viren HIV-1 Bru, HIV-1 Mal, HIV-1 Eli, HIV-2 Rod und
SIV Mac zu hybridisieren, oder  ii) einer Komplementärsequenz
einer Sequenz, wie sie unter i) definiert ist.
Patent DE-19581427-T1 (DE)
Inventor: MELOT DENIS
IPC: C08L77/00
Filed: 1995-12-01
Abstract: PCT No. PCT/FR95/01586 Sec. 371 Date Oct. 15, 1996 Sec. 102(e) Date Oct. 15, 1996 PCT Filed Dec. 1, 1995 PCT Pub. No. WO96/17003 PCT Pub. Date Jun. 6, 1996The invention relates to films based on PA-6 or PA-6,6 and on a copolymer containing polyamide (6 or 6,6) blocks and ploytetramethylene glycol blocks. They have greater impact strengths than PA-6 or PA-6, 6 film.
Patent DE-54951-T1 (DE)
IPC: C07D267/20
Filed: 1981-12-21
Abstract: Dibenz[b,f][1,4]oxazepine derivatives of the formula   <IMAGE> (I) (wherein R1 is a hydrogen atom or a lower alkyl group; R2 is a branched lower alkyl group; R3 is a hydrogen atom, a carboxyl group, a carbamoyl group, a lower alkoxycarbonyl group, or a lower alkoxy group; R4 and R5 are each a lower alkyl group or may, when taken together with a nitrogen atom, form a heterocyclic ring; and A is a lower alkylene group) or salts thereof, a process for preparing the same and pharmaceutical compositions comprising the same are disclosed. The derivatives of the formula above are effective to prevent and treat circulatory diseases, especially angina pectoris, and therefore, useful as medicines.
Patent DE-524843-T1 (DE)
IPC: B60G7/02
Filed: 1992-06-22
Abstract: Resilient joint with high smoothing characteristic and clearance checked by incorporated stops comprising a resilient ring (1) between coaxial rigid elements (2) and (3), characterised in that a layer of considerable thickness (7) covers each axial-effect shoulder (4) of the internal reinforcing bush (2) in order axially to abut against the narrowed edge (8) of the external interlock ring (3), in that the stop function, in each axial direction, gives a smoothing rigidity two to five times lower than the radial rigidity, and in that, beyond the smoothing zone, the axial rigidity becomes progressively greater than the value of the said radial rigidity. 
<??>Applications to vehicle suspension arms and to the antivibrational insulation of onboard or fixed equipment. 
<IMAGE>
Patent ES-2026432-T1 (ES)
IPC: B65H29/00
Filed: 1991-03-09
Abstract: The unwinding device (10) has a vertically adjustable bearing arrangement (17) for the mounting of the roll unit (18). The roll core (19) carries the roll (20) composed of printed products (22) wound together with the wrapping band (21). For unwinding the printed products (22) and for the circumferential drive of the roll unit (18), the latter is lowered onto the round bands (28, 28') drivable in the direction of the arrow A. The band reel (42) comes to bear on the wrapping band (21) on the circumference (104) of the roll (20). The band reel (42) has means for intercepting and taking over the outer end of the wrapping band (21). It is consequently no longer necessary to release the wrapping-band end from the roll (20) by hand and fasten it to the band reel (42). 
<IMAGE>
Patent ES-2086274-T1 (ES)
Inventor: CHATTERJEE SHYAM SUNDER
IPC: A61K127/00
Filed: 1994-07-28
Abstract: PCT No. PCT/EP94/02497 Sec. 371 Date Jan. 29, 1996 Sec. 102(e) Date Jan. 29, 1996 PCT Filed Jul. 28, 1994 PCT Pub. No. WO95/03816 PCT Pub. Date Feb. 9, 1995The preparation of a total extract of leaves and flowers of appropriate Crataegus species is described as well as three new fractions of said total extract and their use as pharmaceutical compositions for preventing sudden death due the cardiac arrest and reperfusion-caused cardiovascular lesions and other reperfusion-caused life-threatening pathological conditions.
Patent CY-1110514-T1 (CY)
Title: Υλικο αντικαταστασης οστου που περιεχει αντιβιοτικο / αντιβιοτικα με επιβραδυμενη απελευθερωση δραστικης ουσιας
Inventor: KÜHN Klaus-Dieter Dr
IPC: A61L27/54
Filed: 2009-10-15
Abstract: Περιγράφεται ένα υλικό αντικατάστασης οστού που περιέχει αντιβιοτικό / αντιβιοτικά, το οποίο χαρακτηρίζεται από το ότι συντίθεται από ένα συμπυκνωμένο μείγμα κοκκωδών προϊόντων του διένυδρου θειικού άλατος ασβεστίου, του ανθρακικού ασβεστίου και τουλάχιστον ενός αντιπροσώπου των αντιβιοτικών αμινογλυκοζιτών, των αντιβιοτικών λινκοσαμιδίων, των αντιβιοτικών γλυκοπεπτιδίων, των αντιβιοτικών μακρολιδίων, των αντιβιοτικών κετολιδίων, των νιτροϊμιδαζολών, των αντιβιοτικών φθοροκινολονών και των αντιβιοτικών οξαζολιδινονών, των αντιβιοτικών στεροειδών, των αντισηπτικών και των μυκητοκτόνων / μυκητοστατικών αντιβιοτικών, τα οποία περιβάλλονται μερικώς ή πλήρως με μια στρώση από τριπαλμιτικό άλας γλυκερίνης και/ή τριστεατικό άλας γλυκερίνης και/ή τριλαουρικό άλας γλυκερίνης και/ή 1-εξαδεκυλαλκοόλη, το οποία συνδέουν μεταξύ τους τα κοκκώδη προϊόντα.
Patent CY-1109620-T1 (CY)
Inventor: SCHUETZ YANNIC
IPC: A61K9/00
Filed: 2009-11-12
Abstract: The aqueous thermosetting neutralized chitosan composition, forming a phosphate-free transparent hydrogel at a temperature higher than 5° C., comprises 0.1 to 5.0 w/w %, based on the total composition, of a reacetylated chitosan having a molecular weight of not smaller than 100 kDa and a deacetylation degree of 40 to 70%, neutralized with an hydroxylated base, and 1 to 30 w/w %, based on the total composition, of a complexing agent selected from polyoses and polyols derived from polyoses. Said composition is useful for the preparation of an injectable formulation.
Patent CY-1111464-T1 (CY)
Title: Οφθαλμικη διαγνωση της ασθενειας alzheimer
Inventor: GOLDSTEIN LEE E
IPC: A61K49/00
Filed: 2011-05-17
Abstract: Η εφεύρεση χαρακτηρίζει μέθοδο διάγνωσης ή παροχής πρόγνωσης αφορώσα την κατάσταση της Ασθένειας Alzheimer σε ένα θηλαστικό με επαφή οφθαλμικού ιστού με ανιχνεύσιμα-επισημασμένη ένωση, η οποία συνδέεται προς μια αμυλοειδή πρωτεΐνη. Μια αύξηση στη σύνδεση της ένωσης προς τον οφθαλμικό ιστό συγκρινόμενη προς κανονικό επίπεδο ελέγχου σύνδεσης δεικνύει ότι το θηλαστικό υποφέρει από Ασθένεια Alzheimer ή είναι σε κίνδυνο ανάπτυξης Ασθένειας Alzheimer.
Patent CY-1113084-T1 (CY)
Title: ΠΑΡΑΓΩΓΟ ΒΕΝΖΙΜΙΔΑΖΟΛΗΣ ΚΑΙ Η ΧΡΗΣΗ ΑΥΤΟΥ ΩΣ ΑΝΤΑΓΩΝΙΣΤΟΥ ΤΟΥ ΥΠΟΔΟΧΕΑ aii
Inventor: KUROITA TAKANOBU
IPC: C07D413/14
Filed: 2012-08-29
Abstract: Η εφεύρεση σχετίζεται με μία διεργασία για την παρασκευή μιας ένωσης του χημικού τύπου (Ι)
Patent CY-1114240-T1 (CY)
Title: Παραγωγα σουλφοναμιδιου τετραϋδροϊσοκινολινης, η παρασκευη τους και η χρηση τους στη θεραπευτικη
Inventor: DIAZ MARTIN JUAN ANTONIO
IPC: C07D409/06
Filed: 2013-05-24
Abstract: Μία ένωση η οποία αντιστοιχεί στον τύπο (I): στον οποίο: το n μπορεί να έχει μία τιμή από 1 έως 6, το -(C)n- αντιπροσωπεύει μία ομάδα –C1-6αλκυλιδενίου, ενδεχομένως υποκατεστημένη με 1 έως 4 υποκατάστατες, το R1 αντιπροσωπεύει ένα άτομο υδρογόνου, μία ομάδα C1-6αλκυλίου, το R2 αντιπροσωπεύει ένα άτομο υδρογόνου, μία ομάδα C1-6αλκυλίου ή μία ομάδα C3-6κυκλοαλκυλίου ενδεχομένως υποκατεστημένες με 1 έως 4 υποκατάστατες, το Β αντιπροσωπεύει το NR3R4, το R3 και το R4 αντιπροσωπεύουν, ανεξάρτητα το ένα από το άλλο, μία ομάδα C1-6 αλκυλίου, ένα άτομο υδρογόνου ή το R3 και το R4 αντιπροσωπεύουν μαζί μία ομάδα C1-6 αλκυλιδενίου, μία ομάδα C2-8 αλκενυλιδενίου, μία ομάδα C1-3 αλκυλιδενο-Ο-C1-3 αλκυλιδενίου ή μία ομάδα C1-3 αλκυλιδενο-Ν(R5)-C1-3 αλκυλιδενίου, όπου το R5 αντιπροσωπεύει ένα άτομο υδρογόνου, μία ομάδα C1-3 αλκυλίου ή ένα C1-6 αλκυλοκαρβονυλίου, ενώ αυτές οι ομάδες C1-3 αλκυλίου και C1-6 αλκυλοκαρβονυλίου μπορούν να είναι υποκατεστημένες ή έναν αμινοκυκλικό δακτύλιο που συνδέεται συνδεδεμένο με έναν άνθρακα με μία ομάδα –NR1-(C)n-, όπως είναι η αζιριδίνη, η αζετιδίνη, η πυρρολιδίνη, η πιπεριδίνη ή η μορφολίνη, οι ομάδες R3 και R4 καθώς και ο αμινοκυκλικός δακτύλιος είναι ενδεχομένως υποκατεστημένες και το άτομο του αζώτου είναι ενδεχομένως υποκατεστημένο. Εφαρμογή στη θεραπευτική.
Patent CY-1114678-T1 (CY)
Title: Μεθοδοι για τον καθορισμο της δραστικοτητας της αδαλιμουμαμπης σε υποκειμενα εχοντα αγκυλοποιητικη σπονδυλιτιδα με τη χρησιμοποιηση των ctx-ii kai mmp3 ως βιοδεικτες
Inventor: MAKSYMOWYCH WALTER P
IPC: G01N33/68
Filed: 2013-11-12
Abstract: Η εφεύρεση παρέχει μια μέθοδο για τον καθορισμό της δραστικότητας ενός αναστολέα του TNFα, όπως ένα αντίσωμα του TNFα, ή ένα μέρος πρόσδεση αντιγόνου αυτού, για τη θεραπεία αγκυλοποιητικής σπονδυλίτιδας (ΑΣ), με τη χρησιμοποίηση ενός βιοδείκτη αποδόμησης κολλαγόνου ή/και ενός βιοδείκτη αρθροθυλακίτιδας.
Patent CY-1115347-T1 (CY)
Title: Συντηγμενες φαινυλ αμιδο ετεροκυκλικες ενωσεις για την προληψη και θεραπεια προκαλουμενων απο γλυκοκιναση ασθενειων
Inventor: BAI HAO
IPC: C07D417/12
Filed: 2014-07-21
Abstract: Η παρούσα εφεύρεση αφορά σε μία ένωση του Τύπου (Ι): ή φαρμακευτικώς αποδεκτό άλας ή διαλύτωμα αυτής, όπου ο Δακτύλιος Α είναι 4-12-μελής ετεροκυκλύλ, ο Δακτύλιος Β είναι συντηγμένος δακτύλιος βενζολίου που επιλέγεται από την ομάδα που αποτελείται από Β(i) και Β(ii), ο Δακτύλιος Α, ο Δακτύλιος Β, ο Δακτύλιος C, R1, R1a, R2, R3, R4, L2, n, t, w και 2 είναι όπως ορίζεται στην προδιαγραφή. Η εφεύρεση επίσης αφορά σε φαρμακευτικές συνθέσεις που περιλαμβάνουν τις ενώσεις του Τύπου Ι και μεθόδους θεραπείας μιας κατάστασης, η οποία προκαλείται με τη ρύθμιση γλυκοκινάσης, η δε μέθοδος περιλαμβάνει χορήγηση σε ένα θηλαστικό μιας αποτελεσματικής ποσότητας μιας ένωσης του Τύπου 1.
Patent CY-1118294-T1 (CY)
Title: Εστερες καρβοξυλικου οξεος αμιδοξιμης της δαβιγατρανης ως προφαρμακα και η χρηση αυτων ως φαρμακο
Inventor: CLEMENT PROF DR BERND
IPC: C07D401/12
Filed: 2016-12-06
Abstract: Η παρούσα εφεύρεση αφορά παράγωγα προφαρμάκου της δαβιγατράνης, τη χρήση αυτών στη θεραπευτική αγωγή ή/και προφύλαξη ασθενειών, ιδιαιτέρως θρομβωτικών ασθενειών, εγκεφαλικού επεισοδίου, καρδιακού εμφράγματος ή/και κολπικής μαρμαρυγής και αρρυθμιών, καθώς και ογκολογικών ασθενειών οποιασδήποτε παθογένεσης.