baber/WOPTO huggingface dataset:
Patent CA-2553895-C (CA)
Inventor: BADORC ALAIN
IPC: A61P35/00
Filed: 2005-02-04
Granted: 2013-04-02
Abstract: Use of 1, 2, 3 substituted indolizine derivatives (I) or their salts in the preparation of medicaments for the treatment of diseases related to the pathological choroid angiogenesis. Use of 1, 2, 3 substituted indolizine derivatives of formula (I) or their salts in the preparation of medicament for the treatment of diseases related to the pathological choroid angiogenesis R 1OH, 1-5C alkoxy, carboxy, 2-6C alcoxycarbonyl, -NR 5R 6, -NH-SO 2-Alk, -NH-SO 2-Ph, -NH-CO-Ph, -N(Alk)-CO-Ph, -NH-CO-NH-Ph, -NH-CO-Alk, -NH-CO 2-Alk, -O-(CH 2) n-cAlk, -O-Alk-COOR 7, -O-Alk-O-R 8, -O-Alk-OH, -O-Alk-C(NH 2):NOH, -O-Alk-NR 5R 6, -O-Alk-CN, -O-(CH 2) n-Ph, -O-Alk-CO-NR 5R 6, -CO-NH-(CH 2) m-COOR 7 or -CO-NH-Alk; Alk : 1-5C alkyl or 1-5C alkylene; cAlk : 3-6C cycloalkyl; R 5, R 6H, 1-5C alkyl or benzyl; R 7H or 1-5C alkyl; R 81-5C alkyl or -CO-Alk; Ph : phenyl (optionally substituted by one or more of halo, 1-5C alkoxy, carboxy or 2-6C alkoxycarbonyl); R 2H, 1-5C alkyl, 1-5C haloalkyl comprising 3-5 halogen atoms, 3-6C cycloalkyl or phenyl optionally substituted by one or more halo, 1-5C alkoxy, carboxy or 2-6C alkoxycarbonyl; A : -CO-, -SO- or -SO 2-; R 9, R 10H or 1-5C alkyl; R 11H or -Alk-COOR 12; R 12H, 1-5C alkyl or benzyl; HetN : heterocycle having 5 or 6 chains comprising at least one atom of N and optionally another heteroatom of N or O; either R 3, R 4H, 1-5C alkoxy, NH 2, carboxy, 2-6C alkoxycarbonyl, OH, NO 2, hydroxyamino, -Alk-COOR 7, -NR 5R 6, -NH-Alk-COOR 7, -NH-COO-Alk, -N(R 11)-SO 2-Alk-NR 9R 10, -N(R 11)-SO 2-Alk, -N(R 11)-Alk-NR 5R 6, -N(R 11)-CO-Alk-NR 9R 10, -N(R 11)-CO-Alk, -N(R 11)-CO-CF 3, -NH-Alk-HetN, -O-Alk-NR 9R 10, -O-Alk-CO-NR 5R 6 or -O-Alk-HetN; or R 3+R 4an unsaturated heterocycle having 5-6 chains (when R 3 is alkoxy, R 4 is -O-Alk-NR 9R 10 or OH, and R 1 does not represent an alkoxy); m : 1-5; and n : 0-5. [Image] ACTIVITY : Antiangiogenic; Ophthalmological; Antiinflammatory; Vasotropic. MECHANISM OF ACTION : Fibroblast growth factor inhibitor.
Patent CA-2556401-C (CA)
Inventor: KOGEL WALTER
IPC: B62D5/04
Filed: 2005-02-07
Granted: 2012-10-23
Abstract: A steering system (1) for a vehicle, in particular a hydraulically assisted power-steering system for a motor vehicle, having a steering spindle (2) that connects a steering handle (3) on its one end to a rotary slide valve or rotary pistons (4) of a steering valve (5) via a first torsion element (6). The steering system (1) has a hydraulic servomotor (7) for actuating an output member (8) of a steering gear (9), a flow,of pressurized media into working chambers of the hydraulic servomotor (7) being controlled by the steering valve (5). The steering system additionally has an electric servomotor (10) for actuating the output member (8). In order to provide a steering system, whose hydraulic servomotor is assisted, during operation, both mechanically by a steering handle and by an electric servomotor and is fail-safe, it is provided that the electric servomotor (10) and the steering spindle (2) act upon a common rotating member (11) between the first torsion element (6) and the rotary slide valve or rotary piston (4).
Patent CA-2558135-C (CA)
Title: Aqueous composition comprising thiazole derivative
Inventor: UENO RYUJI
IPC: A61K31/426
Filed: 2005-03-18
Granted: 2012-08-14
Abstract: The present invention provides an aqueous composition comprising a thiazole derivative of the formula (I):  R1-NH-X-Y-Z (I) wherein R1 is acyl; X is a bivalent residue derived from optionally substituted thiazole; Y is a bond, lower alkylene, lower alkenylene or -CONH-; and Z is a group of the formula:   (see formula Z1)  or (see formula Z2) wherein R2 is a group of the formula: -A-B-D-E   wherein A is a bond, lower alkylene, -NH- or -SO2-; B is a bond, lower alkylene, -CO- or -O-; D is a bond, lower alkylene, -NH- or -CH2NH-, provided that when B is -CO- or -O-, D is not a bond; and E is optionally protected amino, -N=CH2, (see formula E1)  or (see formula E2) wherein Q is -S- or -NH-; and R3 is hydrogen, lower alkyl, lower alkylthio or -NH-R4 wherein R4 is hydrogen, -NH2 or lower alkyl, or a pharmaceutically acceptable salt thereof, and an additive selected from the group consisting of polyol, sugar, sugar alcohol, boric acid or its salt, and water. The aqueous composition is very stable and can be stored for a long time.
Patent CA-2565097-C (CA)
Title: Pharmaceutical composition comprising oxoplatin, the salts and derivatives thereof
Inventor: SALAMA ZOSER B
IPC: A61K9/48
Filed: 2004-10-13
Granted: 2012-08-21
Abstract: The invention relates to a pharmaceutical agent, particularly a chemotherapeutical agent, comprising cis-diammoniumdichloro-trans-dihydroxoplatinum (IV) or salts and/or derivatives thereof in the form of capsules, tablets, creams, ointments and infusion solutions, and to the production of said pharmaceutical agent; the invention also relates to the use of such pharmaceutical agents in the treatment of tumor diseases.
Patent CA-2573223-C (CA)
Inventor: FUKUSHIMA TAE
IPC: C07D405/12
Filed: 2005-08-03
Granted: 2013-05-21
Abstract: The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group -CH=; R1 represents a group -Z-R6, wherein Z  represents a group -CO-, a group -CH(OH)-, or the like, and R6 represents a 5-to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group -O-, a group -CO-, a group -CH(OH)-, a lower alkylene group, or the like; and (A) represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.
Patent CA-2577502-C (CA)
Inventor: LEJARS CLAUDE ROBERT LOUIS
IPC: F01D11/00
Filed: 2007-02-08
Granted: 2014-08-19
Abstract: Turbine engine rotor wheel, this wheel including a disk bearing blades whose roots are engaged and held in an annular recess in the disk, these roots attached to platforms designed to cooperate with an annular gasket mounted in an annular groove on the disk, the annular sealing gasket exerting an elastic force on the blade platforms, maintaining the blades in a correct operating position when the turbine engine stops.
Patent CA-2581643-C (CA)
Title: Parallel hybrid vehicle optimal storage system
Inventor: BLOOMFIELD AARON
IPC: B60W20/00
Filed: 2007-03-13
Granted: 2010-05-11
Abstract: The present invention is a method and apparatus by which power is controlled in a hybrid electric vehicle such that high levels of performance and efficiency are realized. The present invention includes a method and apparatus developed to optimize the use of energy in a hybrid vehicle application from the hybrid energy storage device. The method and apparatus of the present invention is particularly useful with energy storage devices there the energy state, such as the state of charge, is readily determined by an easily measured attribute. Ultracapacitors and hydraulic storage cylinders are examples of the types of energy storage devices to which the present invention may be applied.
Patent CA-2587300-C (CA)
Title: Modular filtration system
Inventor: BARBARO RONALD D
IPC: B01D35/143
Filed: 2005-10-28
Granted: 2011-01-04
Abstract: A filtering system (10) includes a set of modules (40,60,80) which each include filter media (44,64,84) sandwiched between screen assembles (43,63,83). Control assemblies (50) are associated with each module, which each selectively controls flow between a forward flow, a bypass flow and a reverse backwashing flow. The system is used in a filtering method that includes providing an influent flow to the modules and selectively bypassing and providing reverse backwashing flow to the modules when they become occluded.
Patent CA-2589431-C (CA)
Title: Lift apparatuses and method
Inventor: STANISLAO JOSEPH
IPC: B66F7/00
Filed: 2005-11-29
Granted: 2011-04-12
Abstract: A lift apparatus is disclosed. Particularly, a lift apparatus may comprise a support frame and a platform movably coupled to the support frame. Further, the platform may comprise at least one roller and a transmission connected to the at least one roller of the assembly, wherein rotation of the at least one roller causes the platform to move relative to the support frame. Another aspect of the present invention relates to a method of moving a wheelchair lift. Particularly, a wheelchair may be positioned such that at least one wheel of the wheelchair contacts a drive mechanism of a platform, wherein platform is positioned at an initial position. Further, the at least one wheel of the wheelchair may be rotated to cause the platform to move relative to the initial position.
Patent CA-2590906-C (CA)
Title: Deacylation de lipopolysaccharides bacteriens gram-negatifs dans des bacteries gram-negatives
Inventor: TOMMASSEN JOHANNES PETRUS MARIA
IPC: C12N1/21
Filed: 2005-12-16
Granted: 2017-01-03
Abstract: L'invention concerne de nouveaux polypeptides Gram-négatifs présentant une activité 3-O-déacylase de lipide A et capables de modifier et/ou de détoxifier des lipopolysaccharides bactériens Gram-négatifs (LPS). L'invention concerne également des bactéries Gram-négatives, des LPS Gram-négatifs et des compositions comprenant lesdits LPS qui présentent une activité 3-O-déacylase ou sont traités par celle-ci, et qui peuvent être utilisés à des fins pharmaceutiques et/ou vétérinaires, en particulier, pour des vaccins à cellules entières ou acellulaires contre des pathogènes Gram-négatifs, tels que Bordetella pertussis, Bordetella parapertussis et Bordetella bronchiseptica.
Patent CA-2591080-C (CA)
Inventor: SCHEIRER GLEN E
IPC: C10G53/08
Filed: 2005-11-15
Granted: 2012-01-03
Abstract: Systems and processes for removing a first sulfur compound from a hydrocarbon stream. The systems and process utilize at least one reaction vessel incorporating a hydrolysis catalyst suitable for hydrolyzing the first sulfur compound to a second sulfur compound. The reaction vessel also incorporates a sorbent material suitable for absorbing the second sulfur compound. Following hydrolysis of the first sulfur compound to the second sulfur compound and absorption of the second sulfur compound, a hydrocarbon-containing stream having a reduced sulfur content is produced. The hydrolysis catalyst and sorbent material may be provided in separate zones within the reaction vessel or provided as a mixture in a single zone. The hydrocarbon-containing stream having a reduced sulfur content is suitable for a variety of uses, including as a feedstreams for hydrogen plants, process gas streams for power generation plants, or for other uses for hydrocarbon-containing stream having reduced sulfur content.
Patent CA-2596529-C (CA)
Title: Hydrophilic biocompatible adhesive formulations and uses
Inventor: SINGH PARMINDER
IPC: A61K9/70
Filed: 2006-01-27
Granted: 2014-08-19
Abstract: This invention relates to the use of hydrophilic, biocompatible adhesives in drug delivery systems, wound dressings, bioelectrodes, and other systems in which hydrophilic, biocompatible adhesives are desirable. In particular, the invention relates to water-swellable, water-insoluble polymers that in combination render a composition adhesive upon contact with moisture, wherein a first water-swellable, water-insoluble polymer is cationic, a second water-swellable, water-insoluble polymer is anionic, and the polymers are ionically associated with each other to form a polymer matrix.
Patent CA-2598165-C (CA)
Title: Method of operating a night-view system in a vehicle and corresponding night-view system
Inventor: EBNER ROLAND
IPC: G02B23/12
Filed: 2007-08-21
Granted: 2011-04-05
Abstract: In a method of operating a night-view system a video image of the vehicle environment is provided using a night-view sensor, the video image is processed so as to detect the course of the road on which the vehicle moves taking into account information on the course of the road received from a navigation device, and the video image and the detected course of the road are displayed on a display device.
Patent CA-2598281-C (CA)
Title: Gene sptbn2 associe a l'ataxie spinocerebelleuse de type 5 et procedes d'utilisation
Inventor: RANUM LAURA P W
IPC: C12Q1/68
Filed: 2006-02-22
Granted: 2016-08-09
Abstract: La présente invention concerne des méthodes consistant à analyser un polynucléotide SCA5, ainsi qu'à déterminer si le polynucléotide SCA5 comprend une mutation. Lesdites méthodes peuvent être utilisées pour identifier un sujet présentant un risque ou non de développer une ataxie spinocérébelleuse de type 5. La présente invention concerne également des polynucléotides isolés présentant une mutation présente au niveau d'un polynucléotide SCA5.
Patent CA-2598626-C (CA)
Inventor: VAN KANN FRANK JOACHIM
IPC: G01V7/16
Filed: 2006-08-31
Granted: 2013-10-15
Abstract: A gravity gradiometer is disclosed which has a sensor in the form of bars (41 and 42) which are supported on a mounting (5) which has a first mount section (10) and a second mount section (20). A first flexure web (33) pivotally couples the first and second mount sections about first axis. The second mount has first part (25), a second part (26) and a third part (27). The parts (25 and 26) are connected by second flexure web (37) and the parts (26 and 27) are connected by third flexure web (35). The bars (41 and 42) are located in housings (45 and 47) and form a monolithic structure with the housings (45 and 47) respectively. The housings (45 and 47) are connected to opposite sides of the second mount section 20. The bars (41 and 42) are connected to their respective housings by flexure webs (59).
Patent CA-2599417-C (CA)
Inventor: BAILEY RONALD E
IPC: C22C38/12
Filed: 2006-08-29
Granted: 2015-07-07
Abstract: Maraging steel compositions, methods of forming the same, and articles formed therefrom comprising, by weight, 15.0 to 20.0% Ni, 2.0 to 6.0% Mo, 3.0 to 8.0%  Ti, up to 0.5% Al, the balance Fe and residual impurities. The composition may be a first layer of a composite plate, and may have a second layer deposited on the first layer, the second layer having a composition comprising, by weight, 15.0 to 20.0% Ni, 2.0 to 6.0% Mo, 1.0 to 3.0 Ti, up to 0.5% Al, the balance Fe and residual impurities. The first layer may have a hardness value ranging from 58 to 64 RC, and the second layer may have a hardness value ranging from 48 to 54 RC. The first layer may be formed employing powdered metallurgical techniques. Articles formed from the compositions include armored plate.
Patent CA-2600685-C (CA)
Inventor: PASZTOR EGON
IPC: G06F7/00
Filed: 2006-03-02
Granted: 2015-08-11
Abstract: Structured and/or unstructured data about enterprises are acquired from one or more sources such as commercial data providers, enterprise web sites, and/or directory web sites. Strings are extracted from the unstructured data. The strings contain key, value pairs describing facts about the enterprises. The extracted strings are parsed to normalize the keys and values and place them in a machine-understandable structured representation. Some keys and/or values cannot be normalized. The facts are clustered with the enterprise to which they pertain. Normalized facts from different sources are compared and confidence levels and/or weights are assigned to the facts. These confidence levels and weights are used to select the facts that are displayed on a page for the enterprise in a directory.
Patent CA-2603046-C (CA)
Title: Coated article with dark color
Inventor: ANTON BRYCE
IPC: C08J7/046
Filed: 2006-02-27
Granted: 2013-07-02
Abstract: An article is coated with a coating having a dark gray or bronze color. In a preferred embodiment, the coating comprises a nickel or polymer basecoat layer, and a color and protective stack layer comprised of layers of oxygen-rich refractory metal oxycarbides. The preferred dark grey, oxygen rich color layer is zirconium oxycarbide. A refractory metal adhesion layer and a refractory metal oxide top coat layer also may be used.
Patent CA-2603969-C (CA)
Title: Flow control through plural, parallel connecting channels to/from a manifold
Inventor: FITZGERALD SEAN P
IPC: B01J19/00
Filed: 2006-04-07
Granted: 2014-10-28
Abstract: The invention provides apparatuses and techniques for controlling flow between a manifold and two or more connecting microchannels. Flow between plural connecting microchannels, that share a common manifold, can be made more uniform by the use of flow straighteners (1st section) and distributors (2nd section) that equalize flow in connecting channels. Alternatively, flow can be made more uniform by sections of narrowed diameter within the channels.  Methods of making apparatus and methods of conducting unit operations in connecting channels are also described.
Patent CA-2605897-C (CA)
Inventor: VALAIE ARMAN H
IPC: A61M25/06
Filed: 2006-05-26
Granted: 2014-01-28
Abstract: An introducer apparatus includes an outer sleeve (12) and an inner cannula (20) received within the lumen (15) of the outer sleeve. The outer sleeve has a profile such that at least a portion of the distal end of the outer sleeve tapers in the distal direction at an angle not exceeding about 2.5~ relative to a longitudinal axis of the apparatus. The distal open end of the outer sleeve has a wall thickness not exceeding about 0.003 inch, and is sized such that a first wire guide is receivable therethrough. The inner cannula includes a tapered distal end portion. The inner cannula distal open end is sized such that a second wire guide is receivable therethrough, and the first wire guide is not receivable therethrough. The tapered distal portion of the inner cannula extends distal to the distal open end of the outer sleeve, such that a generally smooth diametrical transition is provided between the outer sleeve tapered portion and the open distal end of the inner cannula.
Patent CA-2607580-C (CA)
Inventor: CHANDUSZKO ANDRZEJ J
IPC: A61F2/01
Filed: 2006-05-09
Granted: 2016-12-20
Abstract: A removable blood clot filter includes a number of locator members and anchor members disposed radially and extending angularly downward from a hub. The locator members include a number of linear portions having distinct axes configured to place a tip portion approximately parallel to the walls of a blood vessel when implanted and to apply sufficient force to the vessel walls to position the filter near the vessel centerline. The anchor members each include a hook configured to penetrate the vessel wall to prevent longitudinal movement due to blood flow. The hooks may have a cross section sized to allow for a larger radius of curvature under strain so that the filter can be removed without damaging the vessel wall.
Patent CA-2612080-C (CA)
Inventor: LONGO ANTONIO
IPC: A61K47/26
Filed: 2006-07-11
Granted: 2013-09-03
Abstract: A pharmaceutical composition comprising a camptothecin as active ingredient is herein described. In particular immediate-release therapeutic systems are described for the improved oral absorption of 7-[(E)-t-butyloxyminomethyl] camptothecin, comprising a matrix consisting of liquid amphiphilic substances or having a melting point lower than 60~C, in which the active principle is at least partially dissolved and/or dispersed and/or inglobated.
Patent CA-2616258-C (CA)
Inventor: ESSERS JEROEN
IPC: A01K67/027
Filed: 2005-07-22
Granted: 2014-01-21
Abstract: The invention relates to an animal model of cardiovascular disease and a method of preparation and use thereof. In particular, it relates to a genetically engineered animal model of aortic aneurysms and methods for screening drugs using the animal model. Provided is a genetically-modified, non-human mammal, wherein the modification results in a disrupted Fibulin-4 gene. Also provided is a genetically-modified animal cell containing a disrupted Fibulin-4 gene. The mammal or animal cell can be used a model for a cardiovascular condition or disease, preferably aortic aneurysm, more preferably thoracic aortic aneurysm. Furthermore, methods for identifying or validating a compound that can be used to treat or to prevent an aberrant cardiovascular condition are provided, as well as methods to identify a gene involved in the response to aortic failure.
Patent CA-2618334-C (CA)
Inventor: SCHMITT FRED R
IPC: H01R13/58
Filed: 2008-01-04
Granted: 2014-11-25
Abstract: An electrical wiring arrangement is described that includes at least one electrical cable, which can be fixed on a plug-type connector. The cable ends in the interior of a tubular connecting stub, onto which, a union nut can be attached. A hollow-cylindrical molding can be pressed against the tubular connecting stub in an axial direction in relation to the union nut. The arrangement includes a conical design of the contact faces of the union nut and the molding that bear against each other. This structure exploits the fact that cone faces generally detach from one another under the action of very high forces. The conical design of the contact faces between the union nut and the molding therefore prevents the union nut from being twisted unintentionally in relation to the molding and therefore being capable of being unscrewed from the tubular connecting stub.
Patent CA-2618778-C (CA)
Inventor: SUCHAK NARESH
IPC: B01D53/86
Filed: 2008-01-16
Granted: 2016-04-05
Abstract: The present invention provides for process for inhibiting the levels of nitrogen oxides in process gas streams from sulfuric acid regeneration and production plants. The process gas stream from the waste heat boiler and the candle mist eliminator is contacted with ozone which will react with nitrogen oxides present in the flue gas.
Patent CA-2629438-C (CA)
Inventor: SHIH JESSIE W
IPC: G01N33/53
Filed: 2006-11-09
Granted: 2014-02-25
Abstract: The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.
Patent CA-2642864-C (CA)
Title: Bacteries de l'acide lactique conferant a des produits laitiers fermentes une meilleure texture
Inventor: JANZEN THOMAS
IPC: A23C9/123
Filed: 2007-02-20
Granted: 2013-07-16
Abstract: L'invention porte sur une nouvelle bactérie Streptococcus thermophilus (ST) qui confère une meilleure texture, par exemple, à un produit laitier fermenté.
Patent CA-2657102-C (CA)
Inventor: ROSENZWEIG ALAIN
IPC: H02M3/00
Filed: 2007-07-10
Granted: 2014-10-14
Abstract: Disclosed herein is a fuel cell assembly that arranges a plurality of individual fuel cells into an array. The fuel cells are set into openings formed in a frame. The openings are arranged into the array, such as in columns and rows. A rear cover is sealingly attached to the frame, thereby defining a chamber between the frame and a base of the rear cover, where the chamber serves as a manifold. Optional supports extend from the base to the fuel cells. The void forms a fluid manifold for dispersing fuel for the fuel cells from a fuel reservoir to the fuel cells. Alternatively, the rear cover separates the interstitial space between the rear cover and the frame into compartments, which are fluidly interconnected by channels. The array may also include a functional element electrically connected to the fuel cells configured to transfer power an electronic device.