baber/WOPTO huggingface dataset:
Patent CA-1277986-C (CA)
Title: 1,4-disubstituted piperazine derivatives, pharmaceutical compositions containing them and process for preparing same
Inventor: TOTH EDIT
IPC: A61K31/495
Filed: 1987-04-28
Granted: 1990-12-18
Abstract: 1,4-DISUBSTITUTED PIPERAZINE DERIVATIVES, PHARMACEUTICAL          COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING                         SAME                         ABSTRACT           The invention relates to novel 1,4-disubsti-tuted piperazine derivatives of the general formula (I), pharmaceutically acceptable acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation.         In the general formula (I)   (I) R1 and R2 are the same or different and stand for hydrogen or halogen or a lower alkyl, trihalomethyl or lower alkoxy group.          The compounds of the general formula (I) are therapeutically useful for the treatment of diseases arising from a hypofunction of the dopaminergic system.
Patent CA-1284683-C (CA)
Inventor: O'MAHONY MICHAEL J
IPC: G02B6/42
Filed: 1987-05-05
Granted: 1991-06-04
Abstract: ABSTRACT OF THE DISCLOSURE         A semiconductor travelling wave optical amplifier is presented in a new configuration.  An amplifier chip has the rear facet provided with a reflective coating. Optical signals are input and amplified signals are output via optical fibres and directional coupler.  A single fibre-to-amplifier alignment is required between fibre tail and the front facet.  The front facet is provided with a very low reflectivity coating.  In this configuration the ampli-fication is increased in comparison with the conventional in-line amplifier configuration.
Patent CA-1316421-C (CA)
Title: Internal combustion engine using dynamic resonating air chamber
Inventor: POURING ANDREW A
IPC: F02B23/08
Filed: 1987-06-29
Granted: 1993-04-20
Abstract: ABSTRACT   An internal combustion engine includes a moving piston within a combustion chamber that is temporarily divided into two zones when the piston is at and near its minimum volume position. fuel is confined to a first zone where the fuel is ignited to generate combustion wave energy that drives gas within the second zone in Helmholtz resonance through a restricted passageway. Air from the second zone is periodically expanded into the first zone through the passageway to improve the combustion process in the first zone before the piston moves substantially away from its minimum volume position.
Patent CA-1285875-C (CA)
Title: Combination therapy using immunotoxins with interleukin-2
Inventor: STEVENS PAUL
IPC: A61K39/395
Filed: 1987-07-24
Granted: 1991-07-09
Abstract: ABSTRACT OF THE DISCLOSURE Anti-tumor activity in humans can be augmented by administering to the mammalian host a pharmacologically effective amount of mammalian IL-2 and at least one monoclonal antibody that binds selectively to human tumor cells and/or at least one immunotoxin that binds selectively to human tumor cells. The IL-2 and immunotoxin and/or monoclonal antibody are preferably administered separately to the host.  The composition is useful for prophylactic or therapeutic treatment of such cancers as ovarian and breast cancer.
Patent CA-1304920-C (CA)
Title: Casting process and installation
Inventor: SATO KIMITERU
IPC: B28B1/26
Filed: 1987-08-05
Granted: 1992-07-14
Abstract: ABSTRACT OF THE DISCLOSURE           A casting installation for casting slip into a ceramic product includes a pressure-resistant container having a surrounding wall formed along the inner surface thereof to define an opening through the container.  A casting mold adapted to be located in this opening establishes a space which surrounds the casting mold, the latter being composed of a plurality of separate mold parts each having a plurality of channels therein and having its respective outer face treated to be fluid tight and an inner molding surface.  The assembled mold parts are dimensioned to define a molding cavity, the space being in communication therewith.  The casting mold is firmly clamped, and channels are capable of being depressurized.  A source of slip is operatively connected to the mold cavity, and a fluid source is operatively connected to the space surrounding the casting mold.
Patent CA-1341398-C (CA)
Inventor: MURRAY MARK J
IPC: C07K19/00
Filed: 1987-08-13
Granted: 2002-11-19
Abstract: Des méthodes dexpression dune série danalogues de PDGF biologiquement actifs dans des cellules eucaryotes sont divulguées. Les méthodes comportent généralement lintroduction dans une cellule hôte eucaryote dune construction dADN capable de diriger lexpression et la sécrétion danalogues de PDGF biologiquement actifs dans des cellules eucaryotes. La construction dADN contient un promoteur de transcription, suivi en aval dune séquence dADN appropriée. La séquence dADN pourra coder une protéine substantiellement homologue ou identique à la chaîne A ou la chaîne B du PDGF, ou à une partie de celle-ci, ou à un hétérodimère A-B. En outre, une partie de la séquence dADN peut coder au moins une partie de la chaîne A, tandis quune autre partie code au moins une partie de la chaîne B de PDGF. Des cellules eucaryotes transformées avec ces constructions dADN sont également divulguées. Des protéines dimères exerçant substantiellement la même activité biologique que PDGF sont également divulguées. Plus spécifiquement, les protéines peuvent présenter deux chaînes de polypeptide, une desquelles étant une mosaïque de séquences dacides aminés substantiellement identiques à des portions des chaînes A ou B de PDGF, la deuxième des chaînes pouvant être substantiellement identique soit à la chaîne A soit à la chaîne B de PDGF, ou chacune des chaînes pouvant être substantiellement identique à la chaîne A de PDGF. En alternative, chacune des deux de polypeptides pourra être une mosaïque des séquences dacides aminés décrites ci-dessus. En outre, des protéines comprenant des polypeptides qui sont des variantes ou des dérivés des chaînes A ou B darcs de PDGF sont également divulguées, ainsi que des compositions thérapeutiques contenant ces protéines et des méthodes pour le renforcement du processus de cicatrisation de plaies chez les animaux à sang chaud.
Patent CA-1297627-C (CA)
Inventor: BADER HUBERT
IPC: C08G69/10
Filed: 1987-09-29
Granted: 1992-03-17
Abstract: Abstract of the disclosure Polyamides in which amino acids are incorporated in the polymer backbone via two amino or carboxyl groups and which carry in the .alpha.-position to the amide structure a functional group which is responsible for degradation and active compound release are highly suitable for the preparation of biologically degradable active compound depot preparations having controlled release of the active compound.
Patent CA-1298262-C (CA)
Title: Method and apparatus for guiding filamentary material onto a reel
Inventor: DE VARENNES JOSEPH G C C
IPC: B65H54/28
Filed: 1987-10-14
Granted: 1992-03-31
Abstract: METHOD AND APPARATUS FOR GUIDING FILAMENTARY MATERIAL ONTO A REEL Abstract of the Disclosure In a method and apparatus for guiding a cable core as it is wound onto a reel, a pair of opposed guide pulleys, which are driven reciprocally parallel to the rotational axis of the reel, are mounted for free translational motion in a direction perpendicular to the direction of reciprocal motion, for free pivotal motion about a pivotal axis parallel to the direction of reciprocal motion, and for free pivotal motion about a pivotal axis perpendicular to the direction of reciprocal motion.  This mounting arrangement permits the guide pulleys to assume a position and orientation which minimizes bending of the cable core as it passes between the pulleys, reducing flattening of the cable core during the reeling operation.                          - i -
Patent CA-1282133-C (CA)
Title: Electrical connector comprising combination of individual mating and pin elements as a contact member
Inventor: NODA ATSUHITO
IPC: H01R12/71
Filed: 1987-10-16
Granted: 1991-03-26
Abstract: Abstract of the Disclosure For electrically connecting a conductive terminal member (13) to an electric circuit board (12), an electrical connector includes a contact member (30) which comprises a terminal pin element (31) and a mating contact element (32) as individual parts. The terminal pin element is inserted into a through hole (14) and secured to the electric circuit board by soldering. The mating contact element is mated with the terminal pin element within an insulator housing (16) so that it is possible to correct position error of a contact portion (42) of the mating contact element. The conductive terminal member is inserted into the insulator housing and brought into contact with a contact portion of the mating contact element. As a result, electrical connection is reliably made between the terminal member and an electrical circuit on the electric circuit board.
Patent CA-1305412-C (CA)
Title: Sample focuser for solid-phase analytical device
Inventor: VARITEK VINCENT A JR
IPC: G01N33/52
Filed: 1987-11-19
Granted: 1992-07-21
Abstract: SAMPLE FOCUSER FOR SOLID-PHASE                      ANALYTICAL DEVICE     Abstract of the Disclosure An improved analytical device useful in solid-phase binding assays to determine the presence or amount of an analyte in a test sample.  The device comprises a focuser which directs test sample onto the reactive surface of a solid-phase binding assay device.      The focuser can have any arrangement of passages to correspond to the configuration of the reactive surface present on a solid-phase binding assay device.  The focuser can also include a filter means for filtration of a test sample prior to contacting the reactive area of a solid phase binding assay device.
Patent CA-1321198-C (CA)
Title: Heterocycle-substituted diphosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate
Inventor: EBETINO FRANK H
IPC: C07F9/576
Filed: 1987-12-17
Granted: 1993-08-10
Abstract: NOVEL HETEROCYCLE-SUBSTITUTED DIPHOSPHONATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF TREATING ABNORMAL CALCIUM     AND PHOSPHATE METABOLISM ABSTRACT OF THE DISCLOSURE The    present    invention    relates    to    novel heterocycle-substituted diphosphonic acids, and the pharmaceutically-acceptable salts and esters thereof, in which the diphosphonate-substituted carbon atom moiety is attached to a carbon atom in a nitrogen-containing six membered ring hetero-cycle, preferably a piperidine ring. The heterocycle-substituted diphosphonic acid compounds have the general structure:       wherein Z is a nitrogen-containing six membered ring heterocycle moiety selected from piperidinyl, diazinyl and triazinyl; m, n and m+n are from about 0 to about 10 Q is a covalent bond or a moiety selected from oxygen, sulfur or nitrogen; and R1, R2, and R3 are substituent groups.      The present invention further relates to pharmaceutical compositions containing these novel compounds. Finally, this invention relates to methods for treating or preventing diseases characterized by abnormal calcium and phosphate metabolism by utilizing a compound or pharmaceutical composition of the present invention. dr(ZYA:DR6446a)
Patent CA-1280074-C (CA)
Title: Electronic print board system
Inventor: TADOKORO JOJI
IPC: H04N1/23
Filed: 1987-12-17
Granted: 1991-02-12
Abstract: ABSTRACT OF THE DISCLOSURE           An electronic print board system includes a drawing medium on which images can be erasably written manually, an external input device for supplying external image data, a writer device for erasably writing images on the drawing medium corresponding to the external image data received from the external input device, a device for reading images on the drawing medium and producing output image data corresponding thereto, a device for printing images on a recording medium corresponding to the output image data from the reader device, and a control device for selectively causing the writer device to write images on the drawing medium corresponding to the external image data received from the external input device and for selectively causing the printer device to print images on the recording medium corresponding to the output image data received from the reader device.
Patent CA-1296866-C (CA)
Title: H s removal from gas streams
Inventor: FONG HOWARD L
IPC: C01B17/05
Filed: 1987-12-24
Granted: 1992-03-10
Abstract: A B S T R A C T     A process for the removal of H2S from sour gaseous streams  in which the sour gaseous stream is contacted with a solution containing solubilized iron chelates of a specified organic acid or acids, wherein the contact-ing is carried out in first and second contacting zones, the first contacting zone (3) being a gas-solution mixture formation zone and the second contacting zone (6) comprising a plurality of con-tacting sections (5, 7, 8 and 9) adapted to provide reaction of the H2S in the sour gaseous stream with the iron in the contacting solution without plugging due to deposition of sulphur.            (Figure) Tl.K7600II
Patent CA-1290011-C (CA)
Title: Controlled thermal expansion of generator stator frames
Inventor: BATH DUNCAN T
IPC: H02K15/12
Filed: 1988-03-10
Granted: 1991-10-01
Abstract: Controlled Thermal Expansion of Generator Stator Frames ABSTRACT OF THE DISCLOSURE          In a vertical shaft electric generator there is frequently a problem with differential thermal expansion in the stator core and stator frame. accordingly the temperatures of the stator frame and the stator core are determined from sensors distributed on the stator frame and in the stator core.  The temperatures of the stator frame and core are compared, and when the temperature of the stator frame is less than the temperature core, electric power is provided to heaters spaced about the stator frame to maintain the temperature of the stator frame substantially the same as the temperature of the stator core.
Patent CA-1275970-C (CA)
Title: Cold drawing technique and apparatus for forming internally grooved tubes
Inventor: MAYER DEAN L
IPC: B21C37/20
Filed: 1988-03-16
Granted: 1990-11-06
Abstract: ABSTRACT        Formation of continuous grooves on the internal surface of a tube shell,  in a single continuous cold drawing step, in which the tube shell is first sunk in a die over a reduced diameter cylindrical mandrel portion so that the diameter of the inner surface of the tube shell is reduced to a dimension below the base of the grooves of a grooved plug portion of the mandrel there-by retarding longitudinal movement of a portion of the reduced internal  surface of the sunk tube shell at a plurality  of  circumferentially  spaced  intervals  to effect  formation of  longitudinally continuous shallow grooves.   The mandrel  is allowed to rotate if it is desirable to facilitate the formation of spiral grooves on the tube inner surface.
Patent CA-1302286-C (CA)
Inventor: GROLLIER JEAN-FRANCOIS
IPC: A61Q19/10
Filed: 1988-04-11
Granted: 1992-06-02
Abstract: L'invention concerne une composition détergente et moussante, contenant dans un milieu aqueux cosmétiquement acceptable, un mélange d'agents tensio-actifs comprenant un alkyl sulfate alcalin, de magnésium, d'ammonium ou d'amines; un sel alcalin d'une .alpha.-oléfine sulfonate; un sel alcalin d'alkyl éther sulfate éthoxylé; et un composé répondant aux formules: <IMG> (I) ou <IMG> (II) dans lesquelles R - ? - représente un radical acyle dérivé du coprah. La composition selon l'invention est destinée notamment à être utilisée comme shampooing moussant retardant le regraissage des cheveux.
Patent CA-1317351-C (CA)
Title: Respiratory therapy apparatus with selective display of parameter set points
Inventor: KOU ABRAHAM H
IPC: A61M16/00
Filed: 1988-08-25
Granted: 1993-05-04
Abstract: ABSTRACT OF THE DISCLOSURE     Respiratory therapy apparatus is provided with setting elements such as knobs for inputting set values for various parameters.  A digital display is provided for showing measured values of operational variables.  The set point  for each parameter  is displayed on the  display apparatus along with the measured values only when the knob or setting element for the particular parameter is engaged by the operator's hand.
Patent CA-1329089-C (CA)
Title: Surgical fastener
Inventor: WARREN RUSSELL
IPC: A61F2/08
Filed: 1988-08-29
Granted: 1994-05-03
Abstract: ABSTRACT    A novel surgical fastener is disclosed for attaching soft tissues (e.g. ligaments, tendons and the like) to bone and bone-like structures.  The surgical fastener comprises a shank and an enlarged head disposed on one end of the shank. A central bore passes completely through the fastener along its longitudinal axis, and a plurality of diametrically projecting ribs are disposed along the length of the shank. The foregoing fastener is used to attach soft tissues (e.g. ligaments, tendons and the like) to bone and bone-like structures in the following manner. First, the soft tissue is placed against the bone and then a thin guide wire is passed through the soft tissue and into the bone.  A cannulated drill is when loaded coaxially onto the guide wire and is moved down the guide wire and worked on the guide wire so as to form a hole through the soft tissue and into the bone. Next, the cannulated drill is withdrawn from the guide wire and the aforementioned surgical fastener is loaded coaxially onto the guide wire.  Then a hollow driver is loaded coaxially onto the guide wire and is used to successively strike the head of the fastener so as to drive the shank of the fastener through the soft tissue and into the bone, with the head of the fastener engaging the soft tissue and captivating it against the bone.  Thereafter, the hollow driver is withdrawn from the guide wire, and then the guide wire is removed from the soft tissue and the bone, leaving the soft tissue securely attached to the bone by the surgical fastener.
Patent CA-1340483-C (CA)
Title: Diagnosis of retinoblastoma
Inventor: DRYJA THADDEUS P
IPC: C12Q1/68
Filed: 1989-01-24
Granted: 1999-04-06
Abstract: This invention relates to nucleic acid, or fragments thereof, encoding the retinoblastoma polypeptide, the retinoblastoma polypeptide itself, methods of detecting a defective retinoblastoma gene in human patients, and methods of treating these patients.
Patent CA-1334927-C (CA)
Inventor: HOUSEY GERARD M
IPC: C12Q1/00
Filed: 1989-02-09
Granted: 1995-03-28
Abstract: This invention relates to a general screening method for the discovery and identification of both inhibitors and activators of enzymes, receptors, and other proteins.  In particular, it is concerned with a method of screening for substances which specifically inhibit or activate a particular protein affecting the cultural or morphological characteristics of the cell expressing the protein, especially in a manner apparent to the naked eye.  In brief, the method which we describe herein involves the generation of a cell line purposefully engineered to detect both stimulatory and inhibitory agents which are absolutely specific for any given protein which affects the cultural or morphological characteristics of the cell.  The basis for this invention is my observation that if a protein (the "protein of interest", or POI) which is involved in some manner in cellular growth control is overproduced in cells, then pharmacologic agents which can activate or inhibit the POI can result in altered growth properties of the cells.  The sensitivity of the cells is dependent on their production of the POI, a phenomenon referred to herein as a "graded cellular response" to the pharmacologically active agent.  By this method, tamoxlfen is identified as an inhibitor of PKC activity in cell culture.
Patent CA-1317987-C (CA)
Title: Tandem rod for casement windows
Inventor: CARTER GREGORY G
IPC: E05C9/02
Filed: 1989-02-16
Granted: 1993-05-18
Abstract: ABSTRACT A tandem rod for use between locking ends of locking handles on a casement window or the like has an elongated bar with two or more brackets slidable thereon.  The bar does not have any pre-existing openings by which the brackets can be affixed to the bar.  The potential sites for affixing the first bracket onto the bar are infinite.  The locking handles can be installed in a window first at any desired location and the tandem rod can then be fitted to the existing location of the locking handles.  The tandem rod overcomes the difficulty of installation of previous tandem rods in which the locking handles must be located at pre-determined locations in the bar.
Patent CA-1321826-C (CA)
Title: Method and apparatus for measuring wall erosion
Inventor: DICKS LYNTON W R
IPC: F27D21/00
Filed: 1989-03-16
Granted: 1993-08-31
Abstract: A B S T R A C T     METHOD AND APPARATUS FOR MEASURING WALL EROSION    A method and apparatus for measuring decreasing thickness of the refractory lining of a high pressure, high temperature, water cooled reactor wall, such as a high pressure gasifier, during aggressive corrosion attack. A pulse-echo ultrasonic probe is inserted in the wall, which will corrode at approximately the same rate as the wall of the reactor.
Patent CA-1333887-C (CA)
Inventor: DOI MITSURU
IPC: A61K35/12
Filed: 1989-04-14
Granted: 1995-01-10
Abstract: A method of preparing an immunity memory cell suspension, wherein cells consisting of T-cells are separated from cells collected from an immunity sensitized individual  immunized against a particular pathogen and are mixed with an antibody reactive to a histocompatibility antigen specific to a pre-scribed  species  of  cells  for  producing  antigen-antibody complexes by the antibody and those of the separated cells which have the histocompatibility antigen, whereupon a blood serum is added to the cells containing the antigen-antibody complexes for causing the complement in the blood serum to bind to the antigen-antibody complexes and thereby destroying the cells having the histocompatibility antigen and allowing the remaining cells to persist.  To these persisting cells is then  added  an  antibody  reactive  to  a  histocompatibility antigen specific to immunity memory cells and from the resul-tant cells are separated the immunity memory cells which have the histocompatibility antigen  specific to  immunity memory cells.  Immunity memory cells may be cultured and subcultured successively through a plurality of generations to establish a continuous  line of cells which originates  in the immunity memory cells thus separated from the initial immunity sensi-tized individual.
Patent CA-1330649-C (CA)
Title: Compositions for enhancing the productivity of breeding sows and use of said compositions
Inventor: NGUYEN TAN H
IPC: A61K35/74
Filed: 1989-05-08
Granted: 1994-07-12
Abstract: The present invention relates to a new method for increasing the productivity of sows. In the method according to the invention, Bacillus IP 5832 and/or its spores is/are administered orally to breeding sows.
Patent CA-1323068-C (CA)
Inventor: FODALI ADOLPH
IPC: H01R11/18
Filed: 1989-05-19
Granted: 1993-10-12
Abstract: ADOLPH FODALI                              S&G-3 TIP ATTACHMENT FOR CIRCUIT TESTER PROBE               ABSTRACT OF THE DISCLOSURE        The attachment consists of a single length of resilient wire formed into a coil spring portion, a probe engaging portion and an elongated tip portion. The tip portion extends forwardly from the coil spring portion in a direction generally parallel to the probe and has a uniform cross-sectional dimension throughout its length.  A radially extending portion of the wire is bent to form a recess adapted to engage the insulated wire of the probe, so as to retain the attachment when not in use.