Patent SG-11201908054X-A (SG)
Title: Methods and compositions for treating cancers using antisense
Inventor: ANDREWS DAVID
IPC: C12N15/11
Filed: 2018-03-09
Abstract: Title: METHODS AND COMPOSITIONS FOR TREATING CANCERS USING ANTISENSE (57) : The present disclosure relates to compositions and methods for treating cancers using antisense (AS) nucleic acids directed against Insulin-like Growth Factor 1 Receptor (IGF- IR). The AS may be administered to the patients systemically, or may be used to produce an autologous cancer cell vaccine. In embodiments, the AS are provided in an implantable irradiated biodiffusion chamber comprising tumor cells and an effective amount of the AS. The chambers are irradiated and implanted in the abdomen of subjects and stimulate an immune response that attacks tumors distally. The compositions and methods disclosed herein may be used to treat many different kinds of cancer, for example glioblastoma. PMMA hemirings FIG. 1A W O 20 18/ 1655 28 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 13 September 2018 (13.09.2018) WIP0 I PCT 0111111010 0111 °nolo VIII ono iflo oimIE (10) International Publication Number WO 2018/165528 Al (51) International Patent Classification: C12N 5/02 (2006.01) Cl 2N 15/113 (2010.01) C12N 5/10 (2006.01) Cl 2P 19/34 (2006.01) C12N 15/09 (2006.01) CO7H 21/04 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2018.01) C12N 15/52 (2006.01) (21) International Application Number: PCT/US2018/021706 (22) International Filing Date: 09 March 2018 (09.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/469,003 09 March 2017 (09.03.2017) US 62/629,972 13 February 2018 (13.02.2018) US (71) Applicant: THOMAS JEFFERSON UNIVERSITY [US/US]; 901 Walnut Street, Innovation Pillar, 11th Floor, Philadelphia, PA 19107 (US). (72) Inventors: ANDREWS, David, W.; 8882 Norwood Av- enue, Philadelphia, PA 19118 (US). HOOPER, Douglas, C.; 2 Oregon Trail, Medford, NJ 08055 (US). (74) Agent: VOS STRACHE, Kyle; Cozen O'Connor, 1650 Market Street, One Liberty Place, Suite 2800, Philadelphia, PA 19103 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). [Continued on next page] WO 2018/165528 Al MIDEDIM01101 DIDIREIE311111111111111111111111101111111111111111111 Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))