baber/WOPTO huggingface dataset:
Patent CA-2440845-A1 (CA)
Inventor: EKBLOM JONAS
IPC: C12Q1/68
Filed: 2002-04-04
Abstract: L'invention concerne un procédé pour identifier des molécules de liaison à l'ARN, consistant à prévoir la structure d'un fragment d'ARN par une méthode in silico, à choisir un fragment d'ARN prévu adapté, à synthétiser le fragment d'ADNc correspondant au fragment d'ARN prévu, à insérer le fragment d'ADNc dans la région voisine amont d'un gène d'essai reporter, lequel produit un signal après traduction, de façon à former une construction reporter, puis à effectuer un essai de gène reporter, cet essai contrôlant l'interaction entre une molécule à tester pour son affinité à l'ARN et le fragment d'ARN de la construction reporter. L'invention concerne en outre l'utilisation de fragments d'ARN spécifiques dans la mise en oeuvre du procédé selon l'invention.
Patent CA-2441263-A1 (CA)
Inventor: ZOPPAS MATTEO
IPC: B29C45/73
Filed: 2002-03-14
Abstract: L'invention concerne un dispositif (1) destiné au refroidissement et/ou au conditionnement thermique de préformes ou de paraisons (6) chaudes, en particulier de paraisons utilisées pour la production de bouteilles en matière plastique moulées par soufflage. Ce dispositif limite et/ou réduit les déformations de ces paraisons au cours du refroidissement en maîtrisant les déformations transversales de l'extrémité proche de l'ouverture (8) de la paraison. Ce dispositif comprend une partie de prolongement tubulaire qui enveloppe entièrement la paraison reposant sur sa surface interne au niveau de l'une de ses sections (9). L'invention concerne également le procédé correspondant de refroidissement de la paraison (6).
Patent CA-2443344-A1 (CA)
Inventor: GLEESON JAMES A
IPC: E04D1/04
Filed: 2002-04-03
Abstract: In one embodiment, a siding plank assembly comprising an interlocking featur e that allows the siding plank to be stacked with other siding planks in a manner such that a uniform and deep shadow line is created. The interlocking feature sets the gauge of the exposed plank face and allows for leveling of the plank during installation. The siding plank may be formed from an extrusion process or from the Hatschek process.
Patent CA-2444571-A1 (CA)
Title: 1, 4, 5, 6-tetrahydropyrazolo-¬3, 4-c|-pyridin-7-ones as factor xa inhi bitors
Inventor: PINTO DONALD J
IPC: A61P7/02
Filed: 2002-04-17
Abstract: The present application describes 1, 4, 5, 6-tetrahydropyrazolo-[3, 4-c]- pyridin-7-ones of the following formula or pharmaceutically acceptable salt forms thereof: wherein ring Rb is 3-amido or 4-methoxy, Ra can be cyano, trifluoromethyl, or amido, and R can be a substituted phenyl, a substituted imidazolyl, or a substituted pyridine. Compounds of the present invention ar e useful as inhibitors of trypsin-like serine proteases, specifically factor X a.
Patent CA-2446964-A1 (CA)
Title: Ion trap
Inventor: SENKO MICHAEL W
IPC: H01J49/42
Filed: 2002-05-08
Abstract: There is provided a quadruple ion trap (22) of the type including a ring electrode (24) and first and second end cap electrodes (26, 28), which defin e a trapping volume. The end cap electrodes (26, 28) include central apertures (30) for the injection of ions or electrons into the trapping volume and for the ejection of stored ions during the analysis of a sample. Field faults in the RF trapping field are compensated by addition of a concentric recess or depression in the surface of at least one end cap (26, 28) around the apertu re (30). There is also provided an ion trap mass spectrometer employing the ion trap.
Patent CA-2447066-A1 (CA)
Inventor: ROSEN NEAL
IPC: C12N5/07
Filed: 2002-05-23
Abstract: Cette invention porte sur de nouvelles méthodes de traitement de troubles prolifératifs qui se caractérisent par des niveaux de Her-2 élevés. Un échantillon prélevé sur un patient est d'abord examiné pour déterminer si le niveau de Her-2 est élevé, puis on administre au patient une quantité efficace d'un inhibiteur HSP90.
Patent CA-2448066-A1 (CA)
Title: Chimeric alphavirus replicon particles
Inventor: THUDIUM KENT
IPC: A61K35/76
Filed: 2002-04-11
Abstract: Chimeric alphaviruses and alphavirus replicon particles are provided includi ng methods of making and using same. Specifically, alphavirus particles are provided having nucleic acid molecules derived from one or more alphaviruses and structural proteins (capsid and/or envelope) from at least two or more alphaviruses. Methods of making, using, and therapeutic preparations containing the chimeric alphavirus particle, are disclosed.
Patent CA-2450603-A1 (CA)
Inventor: SHIMAMOTO KATSUNORI
IPC: G06Q50/00
Filed: 2002-06-24
Abstract: In addition to the bidirectional interactive function by using multimedia information including video and audio, multimedia contents such as a moving picture, a still image, and a text are registered in advance, which are fetched when required for performing conference, education, medical care, nursing care, and various consultations, thereby realizing a sophisticated information communication service system. The system includes a bidirectional communication server (10) for performing bidirectional communication by multimedia, a content management server (12) for storing multimedia contents, and a content delivery server (14) for delivering the contents stored in the content management server to a user terminal. The content management server has a content archiver (16) storing material contents and performs delivery according to a scenario in which a combination of material contents is defined along the time axis. The bidirectional communication server also has a data conference function and a chat function as well as a resource management function and a charging function.
Patent CA-2452255-A1 (CA)
Title: 2-adamantyl-4,6-diamino-1,2-dihydro-1-aryl-1,3,5-triazine derivatives as cell prolifiration inhibitors
Inventor: TSITSA POLYXENI
IPC: A61P33/00
Filed: 2002-06-14
Abstract: A series of new 4,6-diamino-1,2-dihydro-1-aryl-2-(1-tricyclo[3.3.1.13,7] decyl]-1,3,5-triazines where the aryl group is a subst ituted or unsubstitut ed phenyl, or naphthyl- group, as pharmaceutically accepted salts or as free bases.The phenyl group substituents are halides, alkyls, alkoxyls or nitro group. One or more of the above substituents are found one or more times eac h one, and in various positions of the phenyl group.The corresponding isomers, stereoisomers, enantiomers, free bases and their complexes with various natural macromolecules and synthetic derivatives of them.The invention refer s to new and prototype compounds inhibiting the proliferation of unwanted cell s that belong to pathogenic microorganisms, to human tissues, to pathological cells, or any pathological cell proliferation. It also refers to the synthes is and the method of synthesis of the above mentioned compounds.The synthesis a nd the method of synthesis thereof of a series characterized by the preparation of the final triazines, by cyclization of the bigouanide hydrochlorides with adamantane-1-carboxaldehyde. Preparation of the inclusion complexes is realized from compexation of the corresponding hydrochlorides of the above mentioned triazines with natural macromolecules or synthetic derivatives.</S DOAB>
Patent CA-2454345-A1 (CA)
Inventor: CIECHANOVER AARON
IPC: A61K47/48
Filed: 2002-07-18
Abstract: The invention discloses anti-tumor activity in the sera of certain reptiles, more particularly in the serum of alligators or crocodiles. The active principle resides in one or more serum proteins or polypeptides that inhibit the growth of mammalian tumor cells in culture while being practically devoi d of such inhibitory activity towards normal cells in culture. The active fractions obtained from the sera show no overt toxicity in healthy mammals, and this novel anti-tumor agent may therefore be used for the prevention, investigation, treatment or diagnosis of neoplasms.
Patent CA-2454666-A1 (CA)
Title: Multi-measurement nmr analysis based on maximum entropy
Inventor: HEATON NICHOLAS J
IPC: G01N1/00
Filed: 2003-12-31
Abstract: A method is disclosed for extracting information about a system of nuclear spins from a region of an earth formation. Specifically, a set of NMR data is acquired fo r a fluid sample located either in a borehole or in a laboratory environment. From the set of NMR data, a multi-dimensional distribution is calculated using a mathematical inversion that is independent of prior knowledge of fluid sample properties.
Patent CA-2455750-A1 (CA)
Inventor: BANER ALBERT LAWRENCE LARRY
IPC: A23K1/00
Filed: 2002-07-11
Abstract: An improved pet food snack and container for holding same and for providing and dispensing a combination of different pet food components, such as a dry pet food snack in combination with a highly palatable paste or sauce, is provided. The container houses separate first and second pet foods in compartments that are structurally integrated. In an embodiment, the container has a removable closure that automatically places the first and second pet foods into contact when the closure is removed. The container may be in the form of a bowl that holds the contacted first and second pet foods. The bowl is suitable for serving the contacted first and second pet foods to a pet. A  pet owner can open the container and serve the contacted first and second pet foods without using any separate utensils.
Patent CA-2456103-A1 (CA)
Title: Salts of substituted 1, 2, 3, 4-tetrahydroquinoline-2-carboxylic acid derivatives
Inventor: ENGLBERGER WERNER GUENTER
IPC: A61P25/18
Filed: 2002-08-05
Abstract: The invention relates to salts of substituted 1, 2, 3, 4-tetrahydroquinoline -2- carboxylic acid derivatives of formula (I), in addition to methods for the production thereof, the use thereof in he production of medicaments and medicaments containing said compounds.
Patent CA-2456346-A1 (CA)
Title: Position-sensitive shock absorber
Inventor: NELSON DEL R
IPC: F16F9/48
Filed: 2004-01-28
Abstract: A position-sensitive shock absorbing device with a single cast body construction is provided. The device has a tubular member, a moveable piston within the tubular member, a first hydraulic fluid chamber defined by an interior volume of the tubular member, a bypass member attached to an outside area of the tubular member. The bypass member surrounds a portion of the tubular member and a second hydraulic fluid chamber is defined by a volume between the tubular member and the bypass member. A  first and a second opening in a side of the tubular member are arranged such that the openings are fluidly connected with each other and with both the first and second hydraulic fluid chamber.
Patent CA-2459406-A1 (CA)
Title: Salvianolic acid b
Inventor: CHEN YUH-LIEN
IPC: A61K31/192
Filed: 2002-08-29
Abstract: This invention features a method for treating inflammatory injury to the cardiovascular system caused by oxidized low density lipoprotein. The method includes administering to a subject in need an effective amount of a composition containing salvianolic acid B.
Patent CA-2461011-A1 (CA)
Title: Electroconductive silicone rubber sponge
Inventor: NAKAMURA AKITO
IPC: C08J9/00
Filed: 2002-09-18
Abstract: An electroconductive silicone rubber sponge composition comprising: 100 parts by weight of a polyorganosiloxane, 1 to 100 parts by weight of an electroconductive filler such as carbon black, 0.01 to 50 parts by weight of a hollow thermoplastic resin powder, 0.1 to 10 parts by weight of a liquid compound that has a boiling point above room temperature, preferably water or an alcohol and a curing agent in an amount sufficient to cure the composition.  An optional reinforcing filler may be added. The composition is capable of forming an electroconductive silicone rubber sponge having uniform and microfine foam cells. Methods for preparing the composition and the sponge are also disclosed
Patent CA-2461385-A1 (CA)
Inventor: KENDALL DAVID PAUL
IPC: D04H3/16
Filed: 2002-10-10
Abstract: Disclosed is a process for preparing a fibrous web. The fibrous web includes a microencapsulated material, such as a microencapsulated phase change material, adhered to the web. Preferably, the web is prepared in a melt-blowing or spun-bonding process. In the melt-blowing (12) process, cooling water (17) containing the microcapsules is used to cool melt blown fibers prior to collection on a collector (16). In the spun-bonding (21) process, microcapsules are applied in liquid suspension or in dry form to a heated web, for instance, after the web has been calendered (28, 29). The fibrous webs thus prepared have numerous uses, and are particularly suited to the manufacture of clothing.
Patent CA-2462114-A1 (CA)
Title: Insulating inserts for elevated temperature process vessels
Inventor: COOPER ARTHUR W
IPC: B01J19/26
Filed: 2002-08-09
Abstract: Insulating members are provided for use in nozzles of elevated temperature process vessels employing a structural metal shell (24), an insulating refractory lining (14) and a corrosion-resistant membrane (18) lining between the structural shell and refractory lining. The insulating members comprise pre-formed insulating sleeves and inserts and are made of a thermally insulating material having sufficient thickness and sufficiently low thermal conductivity such that, when the sleeve or insert is heated by the process temperature during operation of the vessel, the thermal energy transmitted through the sleeve or insert to the membrane is insufficient to raise the temperature of the membrane above a target temperature. The most preferred thermally insulating materials are fluoropolymers such as poly(tetrafluoroethylene) flouropolymer resins.
Patent CA-2465634-A1 (CA)
Title: Animal litter, process for preparing animal litter, and method for removal of animal waste
Inventor: WANG LIN
IPC: B01J20/28
Filed: 2002-11-20
Abstract: Disclosed are animal litters, processes for preparing animal litters, and methods for removal of animal waste. The disclosed litters are made from ingredients including plant meal, grain germ, citrus residue, and grain bran, usually in combination with a cohesiveness agent and a microbial inhibitor.  The litters are provided in the form of discrete plural articles which tend to agglomerate when wetted.
Patent CA-2466271-A1 (CA)
Inventor: BANAS CHRISTOPHER E
IPC: A61F2/06
Filed: 2002-09-12
Abstract: Guidewires and thin-film catheter-sheaths, fabricated using vacuum deposition techniques, which are monolayer or plural-layer members having ultra-thin wall thicknesses to provide very-low profile delivery assemblies for introduction and delivery of endoluminal devices.
Patent CA-2468961-A1 (CA)
Inventor: FRUDAKIS TONY NICK
IPC: G16B20/00
Filed: 2002-12-02
Abstract: L'invention concerne des procédés logiciels destinés à identifier des associations entre des informations génétiques et des caractéristiques génétiques particulières. Une combinaison de polymorphisme de nucléotide simple (SNP) candidate est choisie parmi plusieurs combinaisons SNP candidates pour un gène associé à (ou suspecté d'être associé à) une caractéristique génétique. Des données haplotypiques associées à cette combinaison SNP candidate sont lues pour plusieurs individus ou groupées en un groupe répondant positivement et en un groupe répondant négativement en fonction de la correspondance ou non avec un individu d'un critère caractéristique prédéfini. Une analyse statistique sur les données haplotypiques groupées est réalisée afin d'obtenir une mesure statistique associée à la combinaison SNP candidate. Les actions de sélection, lecture, groupement et réalisation sont répétées si nécessaire afin d'identifier la combinaison SNP candidate possédant une mesure statistique optimale (s'il en existe une). Dans cette approche, toutes les combinaisons SNP possibles sont sélectionnées et analysées de façon statistique. Dans une autre approche de cette invention, une recherche dirigée basée sur les résultats des analyses statistiques préalables des combinaisons SNP est réalisée jusqu'à obtention de la mesure statistique optimale. En outre, le nombre de combinaisons SNP sélectionné et analysé peut être réduit en fonction d'une procédure de test simultanée.
Patent CA-2472108-A1 (CA)
Inventor: WRIGHT DAVID J
IPC: G01N33/543
Filed: 2003-01-06
Abstract: The invention is directed to compositions of mutated binding proteins containing reporter groups, analyte biosensor devices derived from and their use of analyte biosensors both in vitroand in vivo. The binding proteins are covalently bound to a fluorescence dye so that the concentration of an analyte (e.g., glucose) in a given sample is proportional to the fluorescence signal on a scale (Figure 1).
Patent CA-2472748-A1 (CA)
Inventor: RANGAIAH CHETAN
IPC: A61B17/00
Filed: 2004-06-30
Abstract: A surgical instrument for use in a computer assisted navigation system is provided. The instrument includes at least one reference element registerable in the navigational system disposed on a mounting assembly. The mounting assembly is rotatably mounted on the instrument and includes a counterweight or other anti-rotation feature where by the reference element may be maintained in a desired orientation. A rotatable shaft may extend through the mounting assembly and have one end which is securable to a rotary driver suc h as a drill and a second end securable to a rotary tool such as a reamer. The second end of the shaft may utilize a collet assembly to firmly grasp the driven tool and thereby limit relative movement of the tool and the reference elements disposed on the mounting assembly.</S DOAB>
Patent CA-2475201-A1 (CA)
Inventor: STEELE PHILIP H
IPC: G01N22/04
Filed: 2003-02-04
Abstract: A Moisture and Density Detector (MDD) to determine the moisture content and/or density of any dielectric material (130) for various purposes. This device is very useful in detecting the moisture content (MC) of wood and wood-based materials, such as that of lumber in a dry kiln prior to, during and/or following drying. The MDD passes a radio frequency signal (105) between opposed or adjacent capacitance electrodes (110, 120) and measures the signal strength and phase shift of the signal. The addition of phase shift and multiple frequencies improves the accuracy of the results.
Patent CA-2477141-A1 (CA)
Title: Improved disc tumbler lock
Inventor: LINDSTROM MARKO
IPC: E05B63/12
Filed: 2003-03-14
Abstract: A disc tumbler lock, which comprises a lock case (1), which includes a bolt (3) displaceable with a key of the lock and a number of locking discs (13) provided with locking channels (17) and which are displaceable with the key of the lock against the force of a spring (14) to open the lock and for guiding the movements of which the lock case is provided with stationary guiding members (8,9), and a locking pin (12) dependent on the movements of the bolt and which is arranged to cooperate with the locking channels (17) of the locking discs. At least one of the locking discs (13) is equipped with gripping means (18), which, when the bolt (3) is pressed inwards to the lock case are arranged to cooperate with counter means (19) arranged in the lock case for preventing the displacement of the said at least one locking disc (13). Further, the said at least one locking disc (13) is spring-loaded to turn the locking disc around a first guiding member (8) against a second guiding members (9) so that the said second guiding member (9) guides the said at least one locking disc (13) substantially towards the head of the bolt (3) to be protruded out from the lock case.
Patent CA-2477540-A1 (CA)
Title: Intraoral electromuscular stimulation device and method
Inventor: SCARBERRY EUGENE N
IPC: A61N1/02
Filed: 1999-11-12
Abstract: This invention is an intraoral electro-muscular stimulation device (30), and a method to treat a breathing disorder. The stimulation device includes a first electrode (36), a first support member that maintains the first electrode in a sublingual location posterior to a frenulum proximate to one of a first molar, a second molar, and a third molar of a patient. A second electrode (38) is maintained in a sublingual position posterior relative to the first electrode by a second support member. A further embodiment of the stimulation device includes a sensor (54) that detects a respiratory parameter of a patient, outputs a signal indicative thereof. A control unit (50) receives the signal from the sensor, distinguishes between inspiration, expiration, initiates an electrical stimulation at a stimulation time prior to onset of inspiration, and continues stimulation through a portion of inspiration at a level sufficient to induce muscle contraction without pain.
Patent CA-2478375-A1 (CA)
Inventor: CRIPSEY TIMOTHY J
IPC: F16H55/00
Filed: 2003-02-10
Abstract: A method of producing a torque transmission between a driving member and a driven member including the steps of capturing an annular gear within the interior of a hollow cylindrical shell formed of a formable material which is caused to be flow formed around a portion of the exterior of the gear to militate against any relative longitudinal and axial movement between the shell and the gear.
Patent CA-2480351-A1 (CA)
Inventor: COLLINS DESMOND MICHAEL
IPC: C12Q1/68
Filed: 2003-06-10
Abstract: The present invention relates to the discovery of a DNA sequence in sheep types of M. paratuberculosis that differs from the homologous sequence in cattle types of M. paratuberculosis. The invention also provides a nucleic acid amplification technique based on these differences that can be used to distinguish strains of the cattle type from strains of both the sheep types of M. paratuberculosis. The invention also relates to use of these sequences in a nucleic acid amplification technique to distinguish all strains of M. paratuberculosis from other strains of the MAI complex and from strains of t he M. tuberculosis complex.
Patent CA-2482620-A1 (CA)
Inventor: KEUN CHRISTIAN-ANDRE
IPC: B29C65/00
Filed: 2004-09-27
Abstract: Two opposite ends of a handrail stock member are joined to form a handrail having a closed-loop configuration for an escalator or the like. A slot is cut into each end, parallel to a longitudinal reinforcement layer of the handrail stock member. A joint reinforcement insert including longitudinally-oriented high-strength high-stiffness fibers is inserted into the two slots and the two ends are butted together. A thermoplastic matrix material of the handrail stock member in the joint area is heated to a softening or melting temperature and is press-molded to penetrate into the reinforcement insert and bond the insert to portions of the reinforcement layer overlapped by the insert. The matrix material is fused across the junction plane. A pressing mold maintains the defined outer contour of the handrail.
Patent CA-2483283-A1 (CA)
Inventor: HOUBEN RICHARD P M
IPC: A61B5/00
Filed: 2003-04-18
Abstract: Published without an
Patent CA-2485133-A1 (CA)
Title: Novel raw material composition
Inventor: OKAZAKI CHIZUKO
IPC: G06F1/16
Filed: 2003-05-07
Abstract: A raw material composition usable in various applications which comprises th e following ingredients (1) to (3): a composition comprising (a) a polymer ingredient which comprises a vinyl acetate homopolymer or a partial hydrolyzate thereof or comprises either a copolymer of vinyl acetate with on e or more monomers selected from the group consisting of acrylic esters, acrylamide, acrylic acid, methacrylic acid, methacrylic esters, maleic acid, maleic anhydride, and fumaric acid or a partial hydrolyzate of the copolymer , a composition comprising one or more compounds selected from the group consisting of silicone compounds, polyvinyl acetate, cetyl methyl cellulose, polyvinyl alcohol, and epoxy resins, and organic or inorganic particles.</SD OAB>
Patent CA-2486112-A1 (CA)
Title: Allergen mutants
Inventor: HOLM JENS
IPC: A61K38/095
Filed: 2003-05-15
Abstract: Novel recombinant allergens with multiple mutations and reduced IgE binding affinity are disclosed. The allergens are mutants of naturally occurring allergens. The overall .alpha.-carbon backbone tertiary structure is essentially preserved. Also disclosed is a method for preparing such recombinant allergens as well as uses thereof.