baber/WOPTO huggingface dataset:
Patent ES-2339911-B2 (ES)
Title: Aislamiento de celulas hipofisarias multipotentes y diferenciacion invitro de las mismas.
Inventor: ALVAREZ VILLAMARIN CLARA
IPC: A61K35/12
Filed: 2008-11-25
Granted: 2011-03-11
Abstract: Aislamiento de células hipofisarias
multipotentes y diferenciación  in vitro  de las mismas. El
procedimiento de la invención se basa en la presencia en las células
hipofisarias multipotentes de un receptor de la cara exterior de la
membrana, GFRa2+, que no presentan otras células de la hipófisis. El
procedimiento de aislamiento utiliza anticuerpos dirigidos contra
ese receptor y técnicas que permiten la separación de las células a
las que se hayan unido dichos anticuerpos. Una vez aisladas, las
células pueden mantenerse en cultivo sin diferenciarse o puede
provocarse su diferenciación, para dar lugar a células productoras
de hormonas hipofisarias o a células con fenotipo de neuronas. Así,
las células aisladas por el procedimiento de la invención pueden
utilizarse para la producción de hormonas hipofisarias. El uso de
anticuerpos dirigidos contra GFRa2+, acoplados a moléculas
señalizadoras, permite también la identificación de la presencia de
las células hipofisarias multipotentes en cualquier muestra.
Patent ES-2383786-B2 (ES)
Title: Dispositivo de generación de energía a partir de calor solar.
Inventor: MAEMURA TOSHIHIKO
IPC: F24S23/79
Filed: 2008-12-27
Granted: 2012-12-18
Abstract: Dispositivo de generación de energía a partir de calor solar que comprende un poste (4) de soporte que incluye un receptor (1) que recibe luz solar; y una pluralidad de helióstatos (6) que se proporcionan concéntricamente alrededor del poste (4) de soporte y que reflejan la luz solar hacia el receptor (1). El poste (4) de soporte incluye al menos dos receptores (1a, 1b) que están dispuestos en las direcciones ascendente y descendente. El receptor (1a) proporcionado en una posición de lado superior recibe luces reflejadas L1 procedentes de los helióstatos (6a) situados en posiciones lejanas, y el receptor (1b) proporcionado en una posición de lado inferior recibe luces reflejadas L2 procedentes de helióstatos (6b) situados en posiciones cercanas.
Patent ES-2427648-B2 (ES)
Title: Ciclo Brayton con refrigeracion ambiental próxima a la isoterma crítica
Inventor: MARTINEZ-VAL PENALOSA JOSE MARIA
IPC: F02C1/10
Filed: 2012-03-30
Granted: 2014-04-01
Abstract: Ciclo Brayton con refrigeración ambiental próxima a la isoterma crítica.#Ciclo cerrado regenerativo, cuya temperatura mínima del fluido de trabajo es a su vez próxima a la temperatura crítica, pero superior a ella, y próxima a la temperatura ambiente usada para refrigeración del foco frío; seleccionándose el valor de la isóbara de alta en coincidencia con la denominada isóbara suprema, que presenta el máximo valor medio de calor específico a presión constante, dentro de la zona peri-crítica, por encima de la isoterma crítica, y delimitada en presión entre un quinto y cinco veces la presión crítica, fijando la isóbara de baja por proporcionar el máximo de una razón en la que el numerador es el trabajo específico, y el denominador es la suma de los valores absolutos de la variación de entalpía específica de cada etapa del ciclo.
Patent ES-2466090-B2 (ES)
Title: Método de puesta en marcha y control de un proceso biológico para eliminación de amonio mediante la acción de bacterias autótrofas en aguas residuales
Inventor: VAZQUEZ PADIN JOSÉ RAMÓN
IPC: C02F3/02
Filed: 2012-12-07
Granted: 2014-09-17
Abstract: Método de puesta en marcha y control de un proceso biológico para eliminación de amonio mediante la acción de bacterias autótrofas en aguas residuales.#La invención se refiere a un método de puesta en marcha y control de un proceso biológico para eliminar el nitrógeno contenido en aguas residuales mediante una etapa combinada de nitrificación y oxidación anaerobia del ión amonio (Anammox), con bacterias oxidantes y bacterias autótrofas desnitrificantes del filo Planctomycetes, estando ambas poblaciones dispuestas en forma de biopelícula en un mismo reactor, las bacterias oxidantes en el exterior de la biopelícula y las bacterias autótrofas en el interior de la biopelícula creando una zona anóxica, caracterizado porque el reactor se alimenta con un flujo de las aguas residuales y se inyecta aire/oxígeno al interior del mismo de forma continua hasta su parada, manteniendo la dosis de oxígeno disuelto en el reactor a un nivel mayor de 0,6 mg/l, y controlando el aporte de aire/oxígeno al reactor, el tiempo de residencia hidráulico y la alcalinidad en la alimentación.
Patent ES-2504640-B2 (ES)
Title: Sistema de escape de vehículo del tipo motocicleta
Inventor: IWATA MASAYUKI
IPC: F01N13/18
Filed: 2013-09-25
Granted: 2015-07-23
Abstract: La presente invención describe un sistema de escape de un vehículo del tipo motocicleta que permite un fácil ajuste del eje, incluso si el sistema de escape tiene una estructura tal que un silenciador está cerca de un eje de una rueda trasera, que básicamente comprende. Un silenciador tubular (20) conectado a un tubo de escape (11) para la descarga de los gases de escape de un motor (E), donde el silenciador (20) está dispuesto lateral a una rueda trasera (Wr) soportada de manera giratoria mediante un brazo oscilante (58) a través de un eje (40) de forma que se acopla una tapa (30) que cubre el extremo trasero del silenciador (20r) de manera amovible, y donde la tapa (30) está dispuesta en un lado exterior del vehículo en una posición tal que el eje (40) es invisible en una vista lateral del vehículo.
Patent ES-2547030-B2 (ES)
Title: Sistema robótico de asistencia a la cirugía mínimamente invasiva de puerto único capaz de acomodar su movimiento a la anatomía de la pared abdominal
Inventor: RIVAS BLANCO IRENE
IPC: A61B19/00
Filed: 2014-09-25
Granted: 2016-06-13
Abstract: Sistema robótico de asistencia a la cirugía mínimamente invasiva de puerto único con mecanismo de orientación activa capaz de acomodar su movimiento a la anatomía de la pared abdominal que comprende un robot extra-abdominal, que a su vez comprende un efector final que, mediante campos magnéticos, permite posicionar y orientar un dispositivo médico para uso intra-abdominal El robot extra-abdominal comprende además un controlador software capaz de implementar un método para el guiado automático del dispositivo médico para uso intra-abdominal que permite su adaptación a la anatomía de la pared abdominal; y un sistema interfaz de comunicación y control que permite ordenar las acciones deseadas al sistema. Preferentemente, el sistema comprende además un dispositivo médico para uso intra-abdominal, más preferentemente un robot inta-abdominal dotado de un módulo que permite posicionar y orientar un dispositivo médico acoplado o comprendido en el robot intra-abdominal consistente preferentemente en un sistema de visión endoscópica.
Patent ES-2542315-B2 (ES)
Title: Recinto aislado mediante la obtención de vacío por medio de fuerza elástica
Inventor: GONZALEZ BLANCO ENRIQUE
IPC: F17C3/08
Filed: 2014-06-26
Granted: 2015-12-15
Abstract: Recinto aislado mediante la obtención de vacío por medio de fuerza elástica, consistente en un recinto cerrado (1) aislado térmica y acústicamente del exterior mediante unas paredes (3), constituidas por dos láminas de elastómero, las cuales inicialmente se encuentran juntas sin que exista aire ni espacio entre ellas y con sus bordes soldados a unos tacos (6) de elastómero. Estos están unidos a unos medios de tracción (2) y (5) que estiran las dos láminas reduciendo su espesor, y como consecuencia se forma un espacio entre ellas en el que existe el vacío.#Los fluidos son almacenados a una presión ejercida por la fuerza elástica ejercida por el elastómero de sus paredes (3). El volumen del recinto cerrado (1) se ajusta, mediante la fuerza elástica, al volumen de fluido líquido existente. Así se evita la coexistencia de fase líquida con fase gaseosa, aumentando el rendimiento criogénico en la operación de almacenaje.
Patent AU-2001261771-B2 (AU)
Title: In vitro evolution of nucleic acids and encoded polypeptide
Inventor: WILLIAMS RICHARD B
IPC: G01N33/566
Filed: 2001-05-18
Granted: 2005-06-09
Abstract: This invention relates to methods and reagents for selecting a desired protein or nucleic acid molecule by linking mRNA, with known or unknown sequences, to its translated protein to form a cognate pair. The cognate pair is selected based upon desired properties of the protein or the nucleic acid. This method also includes the evolution of a desired protein or nucleic acid molecule by amplifying the nucleic acid portion of the selected cognate pair, introducing variation into the nucleic acid, translating the nucleic acid, attaching the nucleic acid to its protein to form a second cognate pair, and re-selecting this cognate pair based upon desired properties.
Patent AU-2002304419-B2 (AU)
Title: Link assembly for a snake like robot arm
Inventor: GRAHAM ANDREW CRISPIN
IPC: B25J18/06
Filed: 2002-06-12
Granted: 2008-02-21
Abstract: The present invention relates to a link assembly for a robot arm which comprises first and second link members each adapted for limited movement one with respect to the other and resilient elastomeric material disposed between said first and second members and bonded or keyed thereto whereby movement between the first and second member results in shear movement within the elastomeric material disposed there between.
Patent AU-2002318155-B2 (AU)
Title: Solid pharmaceutical formulations comprising modafinil
Inventor: CORVARI VINCENT
IPC: A61K47/32
Filed: 2002-05-24
Granted: 2007-03-01
Abstract: The present invention is related to compositions of modafinil, including compositions of modafinil and one or more diluents, disintegrants, binders and lubricants, and the processes for their preparation thereof.
Patent AU-2002353634-B2 (AU)
Title: Selectively transmitting full or compressed header packets
Inventor: YI SEUNG-JUNE
IPC: H04W4/00
Filed: 2002-11-23
Granted: 2006-04-27
Abstract: A method and apparatus for a transmitter having a radio protocol with an upper layer (PDCP: 10, 12, 14) and a lower layer (RLC: 16, 18, 20) therein used for management of full header packet transmission when transmitting data packets to a receiver are provided. If the upper layer (PDCP) receives from the lower layer (RLC), information of a successful transmission of a full header packet, the upper layer (PDCP) decides to stop sending any additional full header packet that contains the same full header as the previously successfully transmitted full header packet.
Patent AU-2003232720-B2 (AU)
Title: Diagnostic test for determining the concentration of transient proteolytic activity in composite biological media
Inventor: GIESEN PETER
IPC: G01N33/86
Filed: 2003-05-01
Granted: 2009-10-29
Abstract: A method is provided for determining in real time the course of thrombin activity in a sample of blood or plasma as it appears in and disappears from the simple which comprises adding a thrombin substrate to the sample that, per unit time, produces a detectable signal in a quantity that bears relation to the amount of thrombin present. Simultaneously, in a control sample of the same blood or plasma in which thrombin generation is not triggered, the activity of a standard preparation with invariable thrombin activity is measured. The exact molar amount of thrombin present at any moment is obtained by comparison of the activity measured in clotting blood and the simultaneously measured calibrator. The method is useful inter alia for diagnosing hyper- and hypo-coaguable states, either congenital, acquired or drug-induced in humans and animals. Also provided is a kit for use in this method.
Patent AU-2003283101-B2 (AU)
Title: Microcapsules having multiple shells and method for the preparation thereof
Inventor: MOULTON SHAWN
IPC: A23L27/00
Filed: 2003-11-04
Granted: 2008-12-11
Abstract: Single-core and multi-core microcapsules are provided, having multiple shells, at least one of which is formed of a complex coacervate of two components of shell materials. The complex coacervate may be the same or different for each shell. Also provided are methods for making the microcapsules.
Patent AU-2004208524-B2 (AU)
Title: Microencapsulation systems and applications of same
Inventor: BOCHOT AMELIE
IPC: A61K9/16
Filed: 2004-01-20
Granted: 2009-06-11
Abstract: A new micro-encapsulation system (A) is formed from oils (I) and sugars (II), which together form an organized aggregate corresponding to a stack of crystalline structures, specifically an organized combination of hexagonal or pseudo-hexagonal crystalline structures.  An Independent claim is included for the preparation of (A).
Patent AU-2004217582-B2 (AU)
Title: Flooring systems and methods for installation
Inventor: PERVAN DARKO
IPC: A47G27/02
Filed: 2004-03-08
Granted: 2009-10-29
Abstract: A flooring system comprising rectangular floorboards (1,1') provided with connecting means which are mechanically lockable by angling along an upper joint edge of the long sides, 
the connecting means comprising a separate strip (6) of metal which is mechanically joined to a first floorboard (1), 
wherein 
- the strip comprises a locking element configured to cooperate with a locking groove of a second adjacent floorboard (1'), 
- the strip is attached to a horizontally open groove at an edge of the first floorboard (1) 
- a lower lip of the groove is provided with an upwardly facing groove, for positioning of the strip, 
- the lower lip of the groove extends beyond the vertical plane (VP) of the floorboard, 
- a first pair of strip portions (Db1,Db2) cooperates with the groove in order to prevent downward bending of the outer part (7) of the strip (6) in case of tension load, 
- a second pair of strip portions (Ub1,Ub2) cooperates with the groove in order to prevent upward bending of the outer part (7) of the strip so that the strip does not come loose during handling before laying, and 
- a third pair of strip portions (IP,OP) cooperates with the groove for positioning the strip in its inner and outer position relative to the vertical plane VP.
Patent AU-2004229598-B2 (AU)
Title: Indene derivatives as pharmaceutical agents
Inventor: HAN KANG
IPC: C07D213/74
Filed: 2004-04-15
Granted: 2011-01-20
Abstract: Compounds of formula (Ia):   
wherein R 1 , R 2 , R 3 , R 4a , R 4b , R 5  and R 6  are defined herein, as well as other indene derivatives are disclosed herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
Patent AU-2004261053-B2 (AU)
Title: Oral delivery system comprising a biliquid foam
Inventor: COLIN POUTON
IPC: A61K9/12
Filed: 2004-07-30
Granted: 2011-08-25
Abstract: An oral drug delivery system which comprises a biliquid foam comprising: from 1 to 20% by weight of a continuous hydrophilic phase, from 70 to 98% by weight of a pharmaceutically acceptable oil which forms a discontinuous phase, the said pharmaceutically acceptable oil having dissolved or dispersed therein a poorly water-soluble drug in an amount of from 0.1 to 20% by weight and the biliquid foam including therein from 0.5 to 10% by weight of a surfactant to enable the formation of a stable biliquid foam, all percentages being based upon the total weight of the formulation.
Patent AU-2005211984-B2 (AU)
Title: Pesticides
Inventor: MUELLER-HARVEY IRENE
IPC: A01N65/18
Filed: 2005-02-07
Granted: 2010-08-05
Abstract: The invention provides the use of loquat kernel to kill, inactivate or repel pests, in particular nematodes. Also provided is a method of killing, inactivating or repelling nematodes, which method comprises providing loquat kernel and applying the loquat kernel to the nematodes or to an area where the nematodes are likely to exist or to an area to where the nematodes are expected to move. The invention further provides a pesticide comprising loquat kernel and a pesticidally acceptable solvent, carrier, excipient or diluent; and a method of producing a pesticide, which method comprises providing ground, chopped, freeze dried or spray dried loquat kernel.
Patent AU-2005225523-B2 (AU)
Title: Novel pyrrolidine-3,4-dicarboxamide derivatives
Inventor: MARTIN STAHL CHRISTOPH
IPC: C07D401/14
Filed: 2005-03-17
Granted: 2011-10-13
Abstract: The invention is concerned with novel pyrrolidine-3,4-dicarboxamide derivatives of Formula (I) ; wherein R to R and X are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.
Patent AU-2005247598-B2 (AU)
Title: Tumor-associated peptides that bind to MHC-molecules
Inventor: STEVANOVIC STEFAN
IPC: C07K7/06
Filed: 2005-05-24
Granted: 2011-06-02
Abstract: Tumor-associated peptide having a 9-17 residue amino acid sequence from the groups SEQ ID-No. 1-577 from a given sequence protocol. The peptide has the ability to bond with a molecule of the human class I major histocompatibility complex (MHC) proteins. At least one amino acid is chemically modified, or at least one amino acid is deleted, or at least one amino acid is replaced by another amino acid with similar chemical characteristics. Tumor-associated peptide having a 9-17 residue amino acid sequence from the groups SEQ ID-No. 1-577 from a given sequence protocol. The peptide has the ability to bond with a molecule of the human class I major histocompatibility complex (MHC) proteins. At least one amino acid is chemically modified, or at least one amino acid is deleted, or at least one amino acid is replaced by another amino acid with similar chemical characteristics. The N and/or C terminal is available of at least one other amino acid. ACTIVITY : Cytostatic. No biological data is given. MECHANISM OF ACTION : None given.
Patent AU-2005261868-B2 (AU)
Title: Use of a combination of cyclosporine and pegylated interferon for treating hepatitis C (HCV)
Inventor: ASAKAWA KAZUO
IPC: A61P31/14
Filed: 2005-07-13
Granted: 2009-01-15
Abstract: A method of treating a patient having a HCV infection which method comprises administering to said patient a cyclosporin A or a cyclosporin A derivative in association with a conjugate of interferon to a water-soluble polymer in an amount effective to alleviate or eliminate one or more of the signs or symptoms of HCV.
Patent AU-2005279308-B2 (AU)
Title: Protease resistant human and non-human HMGB1 Box-A mutants and their therapeutic/diagnostic use
Inventor: FUMERO SILVANO
IPC: C12N15/00
Filed: 2005-09-05
Granted: 2012-05-03
Abstract: The present invention relates to polypeptide variants of the HMGB-1 highaffinity binding domain Box-A (HMGB1 Box-A) or to a biologically active fragment of HMGB1 Box-A, which are obtained through systematic mutations of single amino acids of the wild-type HMGB1 Box-A protein and which show an increased resistance to proteases and which are therefore characterized by more favourable pharmacokinetic and pharmacodynamic profiles. Moreover, the present invention concerns the use of said polypeptide molecules of HMGB1 Box-A to diagnose, prevent, alleviate and/or treat pathologies associated with extracellular HMGB1.
Patent AU-2005307209-B2 (AU)
Title: 1-[(6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives
Inventor: KIM GUN-DO
IPC: C07D403/14
Filed: 2005-10-18
Granted: 2009-11-19
Abstract: The present invention relates to novel quioxaline-piperazine compounds, 1-[(6,7-substituted alkoxyquinoxalinyl)aminocarbonyl]-4-(hetero)arylpiperazine derivatives of formula (1): and their pharmaceutically acceptable salts, a process for their preparation thereof, and compositions containing such compounds. Therapeutic methods for the treatment of hyperproliferative disorders, including cancers, by administering quioxalin-piperazine compounds are also included.
Patent AU-2006201442-B2 (AU)
Title: A fencing system
Inventor: ANDERSON PETER WILLIAM
IPC: E04H17/16
Filed: 2006-04-06
Granted: 2013-03-07
Abstract: Abstract. In one aspect the present invention broadly resides in a one piece cbnnector for connecting a wire to a structural member, said connector has a wire retraining portion securable about an end of the wire and a member fastening portion fastenable to the member, said portions are at opposed ends. Preferably the one piece connector has no moving parts. More pretrably the one piece connector is a solid and hollow member. Preferably the wire retaining portion and the member fastening port bn are integral to form the one piece connector. Preferably the one piece connector is tubular and the opening at thO wire retaining portion is about or slightly larger than the diameter of the wire. Figure 1 -10 + -- 12 Figure 2
Patent AU-2006210606-B2 (AU)
Title: Antibodies to Oncostatin M receptor
Inventor: ROBERTS PENELOPE E
IPC: A61K39/395
Filed: 2006-02-03
Granted: 2012-03-22
Abstract: The invention provides characterization of the disease and cancer-associated antigen, OSM-R.beta. The invention also provides modulators of OSM-R.beta, including a family of monoclonal antibodies that bind to antigen OSM-R.beta, and methods of diagnosing and treating various human cancers and diseases associated with OSM-R.beta.
Patent AU-2006223663-B2 (AU)
Title: Micro-miniature implantable coated device
Inventor: JIANG HONGGANG
IPC: A61N1/375
Filed: 2006-01-30
Granted: 2012-01-19
Abstract: An implantable micro-miniature device is disclosed. The device comprises a thin hermetic insulating coating and at least one thin polymer or metal secondary coating over the hermetic insulating layer in order to protect the insulating layer from the erosive action of body fluids or the like. In one embodiment the insulating layer is ion beam assisted deposited (IBAD) alumina and the secondary coating is a parylene polymer. The device may be a small electronic device such as a silicon integrated circuit chip. The thickness of the insulating layer may be ten microns or less and the thickness of the secondary layer may be between about 0.1 and about 15 microns.
Patent AU-2006254989-B2 (AU)
Title: System and method for improved train handling and fuel consumption
Inventor: DAUM WOLFGANG
IPC: G05B13/02
Filed: 2006-06-07
Granted: 2012-04-19
Abstract: A method of controlling the operation of a railroad train having a locomotive consist comprising one or more railroad locomotives to improve locomotive consist fuel efficiency, the method including calculating on-board the locomotive consist a load of the train being moved by the locomotive consist based on measuring the movement of the train in response to locomotive consist power settings, determining on-board the locomotive consist a current location of the train, identifying on-board the locomotive consist a change in condition of the track prior to the train reaching the change in track condition, and adjusting on-board the locomotive consist the locomotive consist power setting to optimize locomotive consist fuel consumption based on the calculated load of the train as the train is proximate to the change in track condition.
Patent AU-2006265019-B2 (AU)
Title: Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds
Inventor: CHUANSHENG GE
IPC: C07D401/04
Filed: 2006-06-29
Granted: 2011-10-13
Abstract: The present invention provides new processes for the preparation of unsubstituted and substituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione compounds which are useful, for example, for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-α. The invention can provide improved and/or efficient processes for the commercial production of unsubstituted and substituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione compounds, including, but not limited to, unsubstituted 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-l,3-dione.