baber/WOPTO huggingface dataset:
Patent CR-20200176-A (CR)
Title: Prodrugs of substituted triazole derivatives and uses thereof
Inventor: WASNAIRE PIERRE
IPC: C07F9/09
Filed: 2018-10-17
Abstract: The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro- 2-hydroxypropyl] -4,5-dihydro- 1H-1,2,4-triazol-1-yl Jmethyl)-1- [3-(trifluoromethyl)-pyridin-2-yl] - 1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2- hydroxypropyl] -4,5-dihydro- 1H-1,2,4-triazol-1-yl} methyl)-1- [2-(trifluoromethyl)-phenyl] -1H- 1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2- hydroxypropyl] -4,5-dihydro-1H-1,2,4-triazol-1-yl} methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4- triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
Patent CR-20200637-A (CR)
Title: Novel peptides, combination of peptides as targets and for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers
Inventor: WEINSCHENK TONI
IPC: C12N9/12
Filed: 2017-05-23
Abstract: <p>The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.</p>
Patent EC-SP003793-A (EC)
Title: Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos
Inventor: LYSSIKATOS JOSEPH PETER
IPC: A61K31/39
Filed: 2000-11-30
Abstract: La invención se refiere a compuestos de la fórmula I (gráfico), y a sales farmacéuticamente aceptables, profármacos y solvatos de los mismos, fórmula en la que R1,R7,R8,R9,R10,R11 son como se han definido en la presente memoria. La invención se refiere también a procedimientos para tratar el desarrollo anormal de células, como un cáncer, en mamíferos administrando los compuestos de fórmula I y a composiciones farmacéuticas para tratar dichos transtornos que contienen los compuestos de fórmula I. La invención se refiere también a procedimientos para preparar los compuestos de fórmula I.
Patent EC-SP055918-A (EC)
Title: Procedimiento para modificar la formación de cristal de fármaco
Inventor: PFEFFER SABINE
IPC: A61K9/28
Filed: 2005-07-15
Abstract: Se describe un procedimiento para modificar el hábito de cristal de sustancias de fármaco aciculares, cristales obtenidos a través de dicho procedimiento, y formas de cristal particulares o modificaciones de ácido micofenólico o micofenolato de sodio, así como composiciones farmacéuticas que comprenden los cristales, métodos y tratamiento y usos de los mismos.
Patent EC-SP066885-A (EC)
Title: Regimen de dosificacion en combinacion para eritropoyetina
Inventor: CHEUNG WING K
IPC: A61K38/18
Filed: 2006-09-26
Abstract: La presente invención provee un régimen de dosificación en combinación para eritropoyetina (EPO); en particular, el régimen de dosificación de la presente incluye la administración de por lo menos un primer segmento de dosificación que comprende una primera exposición a EPO capaz de estimular la producción de reticulocitos seguida por una segunda exposición a EPO capaz de sostener la maduración de los reticulocitos en neocitos, y finalmente, glóbulos rojos; ventajosamente, el segmento de dosificación se puede ciclar o repetir, cualquier número de veces y de acuerdo con cualquier esquema de tiempo deseado, con el fin de proveer o mantener cualquier conteo de glóbulos rojos y/o concentración de hemoglobina total deseado; también se proveen métodos de tratamiento que emplean el régimen de dosificación en combinación así como equipos.
Patent EC-SP088407-A (EC)
Title: Milnacipran para el tratamiento a largo plazo del sindrome de fibromialgia
Inventor: RAO SRINIVAS G
IPC: A61K31/165
Filed: 2008-04-28
Abstract: La presente invención se relaciona con métodos para proveer un tratamiento a largo plazo del síndrome fibromialgia (FMS) administrando un inhibidor dual a un paciente con FMS. Particularmente, la presente invención está dirigida a un tratamiento a largo plazo de FMS administrando un inhibidor de serotonina noerpinefrina (NSRI) a un paciente con FMS.
Patent EC-SP961645-A (EC)
Title: Carroceria de vehiculo, arco estructural vehiculo automotor y metodo de fabricacion de un vehiculo
Inventor: SIROLLI FERREIRA ANTONIO EUSTAQUIO
IPC: B62D21/00
Filed: 1996-01-22
Abstract: Carrocería de vehículo, especialmente utilizable en vehículos pesados con carrocería cerrada, tales como omnibuses, y siendo fijable en los largueros de un chasis de vehículo, comprendiendo arcos estructurales conectados entre sí a través de elementos, longitudinales que se caracteriza por el hecho de que, en cada zona de extremidad de los arcos estructurales, se forma un elemento transversal de fijación que es conectable a un larguero.
Patent EC-SP972354-A (EC)
Title: Montaje de manija de grifo
Inventor: TOKARZ STEVEN J
IPC: F16K5/08
Filed: 1997-12-29
Abstract: La construcción de una manija para la operación de un grifo que reduce la cantidad de partes del montaje mientras mejora el rendimiento de la manija. El montaje de la manija incluye una base que está asegurada a la válvula de operación del grifo. Un extremo superior de la base tiene un asiento tubular colocado horizontalmente adaptado para recibir un cuerpo de palanca y una broca axial que se extiende a través del cuerpo. La broca es recibida enroscada dentro del asiento para retener el cuerpo de la palanca dentro del asiento. El cuerpo de la palanca es intercambiable con el fin de alterar la apariencia estética de la manija del grifo.
Patent FR-1587131-A (FR)
IPC: F17C3/02
Filed: 1968-10-18
Granted: 1970-03-13
Abstract: 1,182,578. Liquefied gas storage containers. PITTSBURGH-DES MOINES STEEL CO. 12 July, 1968 [2 Feb., 1968], No. 33297/68. Heading F4P. A cylindrical flat-bottomed inner cold liquefied gas storage tank is supported by a plurality of spaced modules 40, 70'Fig. 4 located between the tank bottom 30 Fig` 1 and the flat bottom 20 of an outer tank and rigidly connected together by planking 90, and the spaces between the modules and that between the cylindrical side walls 32, 22 of the inner and outer tanks are filled with heat insulating material e.g. expanded perlite or mineral wool. The modules 40 which are peripherally arranged beneath the inner tank wall 32 comprise radially extending wood blocks 42, 46, tangential blocks 44 therebetween and top plates 50 all nailed together, whereas modules 70 which support the tank bottom 30 comprise hollow rectangular frames filled with loose insulation 62 and to which are nailed the planks 90. The latter are also nailed to shoulders 56 on modules 40. The exterior of wall 32 is secured by anchor straps 66 which pass between the sector-like space between blocks 40, through a concrete levelling pad (58) Fig. 3, (not shown) and into a concrete foundation 16 supported by piles 14.
Patent GB-1051597-A (GB)
IPC: C25B1/46
Abstract: 1,051,597. Electrolytic production of chlorine and caustic soda. TEIJIN Ltd. Aug.21, 1963 [Aug.24, 1962], No.33136/63. Heading C7B. In the production of caustic soda and chlorine by electrolysis of aqueous sodium chloride solution in a cell divided by an anion-permselective membrane into anode and cathode compartments, the catholyte consisting of aqueous sodium chloride solution purified to remove electrolytically harmful materials such as magnesium ions and the anolyte consisting of a concentrated metal chloride solution, both catholyte and anolyte are continuously passed through the respective electrode compartments and the anolyte is recirculated and maintained of constant composition by removal of excess water e.g. by evaporation, and addition of metal chloride, e.g. as solid salt, externally of the cell. The anolyte salt may be sodium, aluminium or ferric chloride. In order to protect the anionic membrane from the evolved chlorine a porous non- ionic diaphragm, e.g. of pvc cloth, may be disposed between anode and anionic membrane. The process may be applied to a falling film mercury cathode cell or a diaphragm type brine cell using a perforates iron cathode and is used for electrolysing purified sea water typically having a chlorine concentration equivalent to 30 g/1 Na Cl. The cathode compartment may divided by a non-ionic e. g. pvc cloth, diaphragm in the same way as the anode compartment. In cells with divided electrode compartments the electrolyte is supplied to the portion adjacent the anionic membrane.
Patent GB-1053044-A (GB)
IPC: A23B4/052
Abstract: 1,053,044. Smoke generator. F. PETERSEN. Feb. 4, 1964. No. 4753/64. Heading A5G. A generator for the production of smoke for feeding to a food smoking chamber comprises a sawdust supply hopper 1 thermally insulated from a combustion chamber 16 by conical plates 2, 12 packed with, for example glass wool. A rotating shaft 7 carries a stirrer 6, a baffle disc 14 and a scraper 20. Sawdust drops through the centre of the insulated conical plates 2, 12 onto the disc 14 from which it is transferred in controlled amounts to a non-rotating electrically heated disc 18 by an adjustable scraper 17 co-operating with the rotating disc 14. A further scraper 20 continuously removes surplus, partly burnt out, sawdust from the disc 18.
Patent GB-1183445-A (GB)
IPC: B29C48/03
Filed: 1968-04-19
Abstract: 1,183,445. Operable extruder die. UNIROYAL ENGLEBERT DEUTSCHLAND A.G. 19 April, 1968 [2 May, 1967], No. 18548/68. Heading B5A. An operable die assembly for an extruder in which a removable die can be locked in position, comprises a stationary die head fixed to the front of the extruder head, a movable die head pivoted on the extruder head and movable from a closed to an open position, removable die means releasably carried on the moving die head, gib and key locking means mounted on the movable die head, the key being reciprocable between locking and release positions of the die, and on operating mechanism interconnecting the key and a stationary location such that operation in one direction first moves the key to unlock the removable die and then swings the movable die to its open position and operation in the other direction returns the key and movable die to their original positions. The apparatus is preferably designed so that the removable die may be unlocked for changing without opening the die head (this eliminates the need to remove die clamps) and the die head may be pivoted to its open position for cleaning without removing the die. As shown, the fixed die member 1 is rigidly attached to the extruder head 3 by bolts 4 and the movable head 5 is pivotally mounted on axle 7. The removable die members 19 and 20 are held in position by key 12 reciprocally mounted so that it can slide between a locking position determined by gib 23 and an unlocking position determined by stop 22. A sliding member 26 moved by handle 28 and pivot pin 33 can be used to lock the key 12 in the die locking position. A pinion 10 fixedly mounted on rotatable shaft 8 engages a rack 11 attached to key 12 and is rotated by arm 9 which is coupled by rod 15 to a double acting piston and cylinder assembly 16, pivoted to the extruder block. In operation, the rod 15 is in the position shown in solid lines, the key 12 is in the lower locking position the sliding member 26 is as shown, and the movable die 5 is held in position by a clamp (not shown). To change the removable die, the cylinder 16 is actuated to move the rod 15 to position 15<SP>1</SP> rotating the pinion 10 and raising the rack 11 and key 12 into its unlocking position. The dies can then be removed without removing the clamps. To unlock the removable die and open the die cavity, e.g. for cleaning the die assembly clamps are first removed and the piston 16 actuated to move rod 15 first to position 15<SP>1</SP> which moves key 12 to its unlocking position and then to 15<SP>11</SP> to pivot the die about axis 7 as the rack 11 is rigid with the die assembly after abutment of key 12 and stop 22. If sliding member 26 is moved to the left by operation of handle 28 before the cylinder 16 is actuated, the movable die 5 is pivoted to its open position without unlocking the removable die. Friction between the moving parts is preferably arranged so that when closing the assembly the movable die 5 pivots back into position before the key 12 drops into its locking position.
Patent GB-1225147-A (GB)
IPC: C21D9/54
Filed: 1968-12-13
Abstract: 1,225,147. Winding and reeling. KLOCKNER-WERKE A.G. 13 Dec., 1968 [14 Dec., 1967], No. 59363/68. Heading B3E. Metal strip 2 is coiled on to a mandrel having a horizontal axis, with the strip turns 3 wound so as to be uniformly spaced apart by forming a series of protrusions 5 at the edges of the strip, the protrusions extending outwardly of the cross-sectional plane of the strip and adjacent protrusions along one edge extending in mutually opposite directions. Core supporting elements 4 are provided on the coiling mandrel in the region around which the lateral edges of the strip are to be wound to increase the lateral rigidity of the coil. In one embodiment the protrusions 5 are formed on every second turn of the strip.
Patent GB-1225167-A (GB)
IPC: H01G13/00
Filed: 1968-05-16
Abstract: 1,225,167. Capacitors. WESTERN ELECTRIC CO. Inc. 16 May, 1968 [18 May, 1967], No. 23214/68. Heading HIM. In a capacitor comprising strips of metallized dielectric material wound into a roll, wherein a marginal region of each strip is left unmetallized so that the electrodes are offset and extend one to each end of the roll, and wherein the ends of the roll are solder coated for attaching leads, ingress of solder into the central aperture of the roll is prevented by deforming those portions of the ends of the roll which are adjacent to the aperture to close the aperture. As shown, the roll is supported in holder 24 while spin forming tools 26 with concave ends 26-1 deform the ends of the roll. Deformation is limited to the aforesaid marginal regions.
Patent GB-1225186-A (GB)
IPC: D06N3/14
Filed: 1968-08-06
Abstract: 1,225,186. Laminated microporous structures. FARBENFABRIKEN BAYER A.G. 6 Aug., 1968 [9 Aug., 1967], No. 37432/68. Heading B5N. [Also in Divisions B1-B2 and C3] Porous substrates such as leather, woven or knitted textiles, felts, fabrics, paper or cardboard may be laminated to microporous sheet structures which are permeable to water vapour and are prepared by (a) forming a 10 to 70 weight per cent solution of a prepolymer in an organic solvent which prepolymer (1) contains at least 2 functional isocyanate or hydroxyl and/or secondary amino groups, (2) contains at least 2% by weight of free isocyanate groups or if it contains hydroxyl and/or secondary amino groups it should have a content of hydroxyl and/  or secondary amino groups such that the calculated M.W. is below 20,000 and/or the Shore A hardness is below 35, (b) reaction of this prepolymer solution with another compound or compounds which are capable of undergoing polyisocyanate polyaddition using an NCO/OH (NHR) ratio of 0À95 to 1À30, if desired in the presence of a catalyst, (c) addition of at least one further solvent, a "non-solvent" which (1) is miscible with the solvent in step (a) and with the starting materials for the polyaddition in the proportions used, (2) has a relative evaporation number higher than that of the solvent used in step (a), and (3) has practically no solvent action on the end product; (d) shaping the solution while both the solvent and non-solvent are allowed to evaporate, both step (c) and the shaping being carried out before the polyaddition reaction of step (b) is complete. The microporous sheet structure is preferably transferred to the porous substrate by the reverse process and attached to it by discontinuous layers of adhesive. In Example 5 a polyurethane-urea foil is applied by the reverse process to a bonded polyester fibre fleece. Reference has been directed by the Comptroller to Specification 1,150,995.
Patent GB-1225417-A (GB)
IPC: B29C48/09
Filed: 1968-07-08
Abstract: 1,225,417. Extruding thermoplastics sections. VERENIGD PLASTIC VERKOOPKANTOR N.V. 8 July, 1968 [8 July, 1967], No. 32554/68. Heading B5A. In the extrusion of thermoplastic polymeric solid sections, the extrudate from extrusion nozzle 1 passes through an air gap before entering a cooled sizing die 3 having a converging inlet passageway 4, the arrangement being such that extrudate accumulates as a cavity-free mass in the air gap prior to being drawn through die 3 by take-off rollers 8. As shown, extrusion orifice 2 is circular in cross-section whereas the product 9 is of I cross-section. However, if the product is considerably elongated, orifice 2 may be elongated in the same sense. Die 3 is cooled by liquid, e.g. water, from a spray ring 6. The preferred length of the air gap is between 1 and 5 inches and the crosssectional area of the accumulated material is at least 1À5 times and preferably at least 6 times that of orifice 2. Specific polymers mentioned are PVC, polystyrene, polyethylene, polyaminocaproic acid and polyethylene terephthalate.
Patent GB-1227446-A (GB)
IPC: C08G18/34
Filed: 1968-05-22
Abstract: 1,227,446. Polyimides from polyisocyanates. SOC. RHODIACETA. 22 May, 1968 [26 May, 1967], No. 24542/68. Addition to 1,105,437. Heading C3R. A polyimide comprises divalent organic radicals R containing at least 2 carbon atoms and n-valent radicals R<SP>11</SP> containing at least n carbon atoms where n is greater than 1 each comprising at least 2 organic groups linked by a group of formula where Y and Y<SP>1</SP> are alkyl, aryl or cycloalkyl, the radicals R and R<SP>11</SP> being linked by groups of formula in which R<SP>1</SP> is organic and the chain is terminated by -NCO groups or groups of formula Radical R may contain the following groupings: where X is alkylene, dioxyalkylene, cycloaliphatic or arylene and Y and Y<SP>1</SP> are alkyl, aryl or cycloaliphatic. The polyimide may also contain n<SP>1</SP> - valent organic radicals R<SP>111</SP> which contain at least n<SP>1</SP> carbon atoms where n<SP>1</SP> is greater than 2. These radicals may contain the following groupings: The polyimide may be of M.W. 1000-10,000. It may be prepared in solution from the corresponding polyisocyanate(s) and tetracarboxylic acid or the dianhydride thereof. The reaction temperature may be 40-350‹ C. Solvents specified are DMA, DMF, DMSO and NMP. Polyisocyanates specified include 4,4<SP>1</SP>- triphenylphosphate di - isocyanate, 4,4<SP>1 </SP>- triphenylthiophosphate di-isocyanate, 4,4<SP>1</SP>-triphenylthiophosphine di-isocyanate, bis(4 - isocyanatophenyl) benzene thiophosphonate, bis(4 - isocyanatophenyl)benzenephosphonate, 4,4<SP>1</SP>,4<SP>11</SP> - triphenylthiophosphate tri-isocyanate, 4,4<SP>1</SP>,4<SP>11</SP> - triphenylphosphine phosphine oxide tri-isocyanate, 4,4<SP>1</SP>,4<SP>11</SP> - triphenylphosphonate tri-isocyanate, 4,4<SP>1</SP>,4<SP>11 </SP>- triphenylthiophosphate tri - isocyanate, 4,4<SP>1</SP>,4<SP>11 </SP>- triphenylmethane tri - isocyanate, 2,4,4<SP>1</SP>- diphenylether triisocyanate, 4,4<SP>1</SP>,4<SP>11</SP> - triphenylphosphate triisocyanate, 4 - methyl - 2,4,6 - tri - isocyanatobenzene, 1,3,5 - trimethyl - 2,4,6 - tri - isocyanatobenzene, 1,3,7 - naphthalene tri - isocyanate, 2,4,4<SP>1</SP>- diphenyl tri - isocyanate, 3- methyl - 2,4,4<SP>1</SP>- diphenylmethane, tri - isocyanate 4,4<SP>1</SP>- dimethyl - 2,2<SP>1</SP>,5,5<SP>1</SP> - diphenylmethane tetraisocyanate, polyphenylene polymethylene polyisocyanate and polyoxyphenylene polyisocyanate. The acid may be pyromellitic acid dianhydride.
Patent GB-1228080-A (GB)
IPC: C07D231/50
Filed: 1969-07-15
Abstract: 1,228,080. 4 - (Aryloxyacetamido) - 2,3- dimethyl -1 - phenyl - 5 - pyrazolones. LABORATOIRES VALDA. 15 July, 1969 [15 July, 1968], No. 35618/69. Heading C2C. Novel 4 - (aryloxyacetamido) - 2,3 - dimethyl- 1 -phenyl-5-pyrazolones of the formula wherein R 1  and R 2  are the same or different and each may be H, C 1-4  alkyl, C 1-4  alkoxy or halogen are prepared by either reacting the appropriate aryloxyacetic acid chlorides or aryloxyacetic acids with 4-amino-2,3-dimethyl- 1 .phenyl-5.pyrazolone. Pharmaceutical compositions, having antipyretic, anti-inflammatory and analgesic activity and suitable for oral, parenteral, rectal or topical administration contain the above novel compounds and pharmaceutically acceptable carriers.
Patent GB-1228894-A (GB)
IPC: B65D83/14
Filed: 1968-09-17
Abstract: 1,228,894. Dispensing liquids by gaseous pressure. GILLETTE CO. Sept.17, 1968 [Sept. 21, 1967], No.44218/68. Heading F1R. A dispenser, e.g. for viscous cosmetics and food products, comprises a product container 2 with a dispensing outlet 16, and a propellant container 8 supported by ribs 10 in container 2 and having a discharge valve assembly 18 operable by manual depression of a diaphragm 26, a vent 30 being provided in the diaphragm or in the neck of container 2, Figs.4 to 6 (not shown), so that the gas space 6 in container 2 is vented after each dispensing operation. Vent 30 is closed by the finger operating valve 18 during dispensing. Outlet 16 is connected to the bottom of container 2 by a tube 12, or by a passage formed in the container, Fig. 5 (not shown). (For Figure see next page)
Patent GB-1229866-A (GB)
IPC: C07D405/12
Filed: 1968-04-05
Abstract: 1,229,866. α - Glyceryl esters of indole derivatives. SCHERICO Ltd. 5 April, 1968 [10 April, 1967], No. 51238/70. Divided out of 1,229,865. Addition to 1,229,865. Heading C2C. Novel compounds I and their salts in which R<SP>1</SP> is 1-4 C alkylthio or halo; R<SP>2</SP> is 1-4 C alkyl; R 3  = 1-4 C alkoxy or di-(1-4 C alkyl)amino; Alk is -CH 2 -, =CHCH 3  or -CH 2 CH 2 -; and the dotted line indicates an optional bond are prepared by (a) reacting LCOOH or a functional derivative thereof with HOQ or a functional derivative thereof (L is the grouping II and Q is -CH 2 CHOHCH 2 OH or a cyclic ketal or acetal thereof, CH 2 CH=CH 2  or a 2,3 - epoxypropyl group and where necessary ring opening the ketal, hydrolysing the epoxy group or oxidizing the allyl ester, (b) reacting LCOOH with D-CH(OQ) 2  (D is a secondary amino group) or (c) reacting a compound VII with a compound VIII and where necessary in (b) or (c) modifying the group Q as under (a). Intermediates isolated include those described under parent Specification from which this application is divided and allyl - (1 - p - chlorobenzoyl - 2 - methyl - 5 - methoxy - 3 - indolyl)- acetate prepared as under (a) above. Pharmaceutical compositions comprise a compound I or a suitable salt thereof in conjunction with a suitable excipient, have anti-inflammatory effect and may be administered orally, rectally, topically or parenterally.
Patent GB-1230113-A (GB)
IPC: G03G15/00
Filed: 1968-10-07
Abstract: 1230113 Transferring developed electrostatic images RANK XEROX Ltd 7 Oct 1968 [12 Oct 1967] 47385 Headings B8R RL R247 R248 R222 R276 and R279 A sheet 12 which has received a developed electrostatic image from a seerographic drum 10 is  stripped from the drum by the combination of a detacking corotron 20 and an air blast from a manifold 22. The corotron 20 produces a charge opposite to the electrostatic charge provided by a transfer corotron 16 to cause the leading edge of the sheet 12 to be repelled from the drum. The detacking corotron 20 may have an impressed A.C. voltage or an adjustable D.C. bias. Nozzles (35) Fig. 2 (not shown) direct air against the undersides of the stripped sheets to maintain contact with a vacuum conveyer 21.