baber/WOPTO huggingface dataset:
Patent DO-P2003000678-A (DO)
Title: Derivados de heterobiarilo como inhibidores de metaloproteinasa de la matriz
Inventor: BUNKER AMY MAE
IPC: C07D521/00
Filed: 2003-07-29
Abstract: Esta invención proporciona compuestos definidos por la Fórmula I O una de sus sales farmacéuticamente aceptables; En la que R1, Q, S, T, U, V y R2 son como se han definido en la memoria La invención proporciona también composiciones farmacéuticas que comprenden un compuesto de Formula 1, o una de sus sales farmacéuticamente aceptables, como se ha definido en la memoria descriptiva, junto con un vehiculo, diluyente o excipiente farmacéuticamente aceptables. La invención proporciona también métodos para inhibir una enzima MMP-13 en un animal, que comprenden administrar al animal un compuesto de Formula 1, o una de sus sales farmacéuticamente aceptables. La invención proporciona también métodos para tratar una enfermedad mediada por una enzima MMP-l3 en un paciente, que comprende administrar al paciente un compuesto de Formula 1, o una de sus sales farmacéuticamente aceptables, ya sea a solas o en una composición farmacéutica. La invención proporciona también métodos para tratar enfermedades tales como cardiopatías, esclerosis múltiple, osteoartritis y artritis reumatoide, artritis distinta de la osteoartritis y de la artritis reumatoide, insuficiencia cardiaca, enfermedad inflamatoria intestinal, insuficiencia cardiaca, degeneración macular relacionada con el envejecimiento, enfermedad pulmonar obstructiva crónica, asma, enfermedades periodontales, soriasis, aterosclerosis y osteoporosis en un paciente, que comprende administrar al paciente un compuesto de Formula 1, o una de sus sales farmacéuticamente aceptables, ya sea a solas o en composición farmacéutica. La invención proporciona también combinaciones, que comprende un compuesto de Formula I, o una de sus sales farmacéuticamente aceptables, junto con otro componente farmacéuticamente activo como se ha descrito en la memoria descriptiva.
Patent DO-P2006000084-A (DO)
Title: Compuestos sulfoximino-macrociclicos y sus sales, composiciones farmaceuticas que comprenden dichos compuestos, metodos de preparacion y usos de los mismos
Inventor: SCHWEDE WOLFGANG
IPC: A61K31/529
Filed: 2006-04-07
Abstract: Sulfoximinas macrocíclicas de fórmula general I: donde A, X, Y, R', R2 y R3 tienen los valores que se indican en la memoria descriptiva y en las reivindicaciones, y sales de las mismas; composiciones farmacéuticas que comprenden las sulfoximinas macrocíclicas, y un método para preparar las sulfoximinas macrocíclicas, así como el uso de las mismas para fabricar una composición farmacéutica para el tratamiento de enfermedades de crecimiento vascular desregulado o de enfermedades que están acompañadas por crecimiento vascular desregulado, donde los compuestos interfieren de manera eficaz con la angiopoyetiria y por lo tanto influyen en la señalización de Tie2.
Patent DO-P2007000045-A (DO)
Title: Derivados espiro sustituidos con aza
Inventor: MAKOTO JITSUOKA
Filed: 2007-03-07
Abstract: SUSTANCIA QUE ANTAGONIZA LA UNION DE HISTAMINA A UN RECEPTOR H3 O QUE INHIBA LA ACTIVIDAD HOMEOSTATICA DEL RECEPTOR H3 SE PORPORCINA UN COMPUSTOS DE LA FORMULA I SIGUIENTE O SU SAL FARMACEUTICAMENTE ACEPTABLE
Patent DO-P2017000048-A (DO)
Title: Compuestos aminopirimidinilo como inhibidores de jak.
Inventor: IVAN VIKTOROVICH EFREMOV
IPC: C07D519/00
Filed: 2017-02-21
Abstract: Un compuesto que tiene la estructura: Donde las variables se definen dentro de la misma. También se proporcionan procedimientos para la fabricación de medicamentos útiles en el tratamiento como inhibidores de janus cinasa y composiciones farmacéuticas que contienen los compuestos de la invención y combinaciones con otros agentes terapéuticos.
Patent DO-P2022000168-A (DO)
Title: Vacuna contra hpv
Inventor: MARIAN E GINDY
IPC: A61P31/20
Filed: 2022-08-12
Abstract: La presente divulgación proporciona, entre otras cosas, una composición farmacéutica que incluye un adyuvante de nanopartículas lipídicas y una vacuna contra el virus del papiloma humano (HPV) que comprende partículas similares a virus (VLP) de HPV de al menos un tipo de virus del papiloma humano (HPV) seleccionado del grupo que consiste en los tipos de HPV: 6, 11, 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 55, 56, 58, 59, 66, 68, 73 y 82.
Patent EC-SP11010903-A (EC)
Title: Dispensador
Inventor: LOVELL FRANCIS JOHN
Filed: 2011-03-18
Abstract: Un dispensador (1) para ser empleado con un portador de medicamentos (2). El portador de medicamentos (2) contiene al menos un producto de medicamento (8) que puede ser liberado de él. El dispensador (1) comprende un cuerpo (12), un conducto de recolección (18) y una abertura para dispensar (16). El cuerpo (12) incluye una porción de sujeción (14) para retener un portador de medicamentos (2). La porción de sujeción (14) incluye al menos una abertura de entrada (32) dispuesta para recibir un medicamento (8) liberado de un portador de medicamentos (2) ahí retenido. El conducto de recolección (18) conecta la al menos una abertura de entrada (32) y la al menos una abertura para dispensar (16). El dispensador (1) está configurado de tal manera que un medicamento (8) dispensado de un portador de medicamentos (2) que está sobre él pasa a través de la abertura de entrada (32) y al conducto de recolección (18) a partir del cual se puede dispensar a través de la abertura para dispensar (16).
Patent GB-189709068-A (GB)
Title: Improvements in the Dials and Computing Scales of Spring Balances.
Inventor: JUNGE CHARLES
Filed: 1897-04-09
Granted: 1897-11-13
Abstract: 9068. Junge, C., [Myers, D.]. April 9. Value-indicating apparatus; spring balances.- The value scales are printed in concentric columns a' ... a<8>, the values at even and odd rates being printed in different colours and running round the dial in opposite directions so as to be read right way up in the slots c, c<1> respectively. These slots are graduated with the rate scales. The outermost column a shows weights. The dial, which is of paper, cloth, celluloid, &c., is fixed to a frame consisting of a central hub connected to an annular ring, flanged on its inner edge, by corrugated spokes. The hub may be strengthened by a flanged disc. To keep the dial stretched and so prevent puckering, the ends of springs H, soldered in the middle to the frame, are bent outwards, and pass freely through holes in the frame and then into eyeleted holes a<9> in the dial. These holes being placed nearer the centre than the centre of the springs, an outward pull is exerted upon the periphery of the dial.
Patent GB-189709655-A (GB)
Title: Improvements in Movable Barriers for Level-crossings on Railways.
Inventor: PASSAVANT-ISELIN HANS FRANZ
Filed: 1897-04-15
Granted: 1897-05-15
Abstract: 9655. Passavant-Iselin, H. F. April 15. Crossing gates and barriers.-Sliding or swinging barriers R, Fig. 1, are locked by a spring catch S<1> engaging a fixed stop W. The catch is liberated by a treadle T. Vertically-swinging barriers X, Fig. 4, are locked by the pivoted catch S<1> which is liberated by a cam V<1> bearing under the arm D<1> of the catch lever and worked by the opening-wire K<1> which is connected to the barrier through a spring L'.
Patent GB-189712009-A (GB)
Title: Improvements connected with the Lighting of Incandescent and other Gas Burners.
Inventor: WHITE CHARLES
Filed: 1897-05-14
Granted: 1897-07-24
Abstract: 12,009. White, C., and White, T. H. May 14. Lighting gas.- To allow of the pilot jet being extinguished while the main burner is alight, the gas supply to the main and pilot burners is automatically controlled by a valve arranged between the ordinary bye-pass gas cock and the burners. When the gas is turned on to the main burner by the ordinary cock, the pressure of the gas raises a flexible diaphragm A, or a float or equivalent device, and causes the end C' of the pivoted lever C to open the channel H to the main burner, and to close the bye-pass channel N. Similarly, when the gas cock is turned off, the pressure of the small quantity of gas traversing the bye-pass is insufficient to support the diaphragm A, and the lever C falls, opening the byepass channel N and closing the main channel H. The construction shown may be modified.
Patent GB-189716254-A (GB)
Title: Improvements in and relating to Linotype Machines, more particularly in connection with the Production of Half or other Measures or Type Bars.
Inventor: THORNELOE WILLIE JACKSON
Filed: 1897-07-09
Granted: 1898-07-09
Abstract: 16,254. Thorneloe, W. J., and Hardy, T. J. July 9. Linotype machines.-Relates to means for casting short linotypes of half, one third, or other measure. In Fig. 1, portions of a machine are shown. A block or dummy a, equal in length to the required diminution of the linotype, is placed in the sliding bar b of the assembly-box, and a filling-piece or block e of the same length is placed in the mould slot, reducing the effective part d of the slot to the required length. A block is also placed in the vice jaws.
Patent GB-189729282-A (GB)
Title: An Improved Toy, Applicable for use in Playing with Skittles.
Inventor: SCHOENER KARL
Filed: 1897-12-10
Granted: 1898-02-12
Abstract: 29,282. Sch÷ner, K. Dec. 10. Balls, delivering; games played with skittles.- Relates to toy apparatus which may or may not be used with a set of skittles. The frame A is provided with inclined troughs and openings B, G, C. A ball 0, passed through the opening B, rolls down to a receptacle D. When using with skittles, a slide E is raised, allowing the ball to roll out towards the skittles.
Patent GB-189729925-A (GB)
Title: Improvements in Bicycle Driving Gear.
Inventor: GENTRY OLIVER HOWARD
Filed: 1897-12-17
Granted: 1898-11-12
Abstract: 29,925. Gentry, O. H. Mav 25, [date claimed under Sec. 103 of Patents &c. Act, A.D. 1883]. Toothed gearing particularly applicable to bicycles. Toothed wheels b and d, keyed to the crank axle and rear wheel hub respectively, are connected by a toothed ring e mounted in antifriction bearings on a ring g secured by suitable clips m to the stay i. Fig. 3 shows a form of ball bearing, the balls running in grooves in the rings e and g. The balls are introduced through a hole in the ring g, the hole being normally closed by a suitable plug. In a modification shown in Fig. 11, the balls are replaced by rollers q mounted in spacing-rings s secured together by spacing-pins.
Patent GB-189730528-A (GB)
Title: Improvements in Adjustable Stands for Bicycles.
Inventor: AUFDERHEIDE JOHANN HEINRICH
Filed: 1897-12-24
Granted: 1898-04-23
Abstract: 30,528. Aufderheide, J. H. Dec. 24. Stands for bicycles. An upright a is supported by legs b, and a stay f, having a bifurcated end e, has pivoted to it a bent piece k. Pivoted to the latter, and adapted to be secured in a vertical position by a pin s, is a rod g having arms c provided with clips i which grip the cycle frame as shown. A cord r, wound round the frame of the cycle and the rod g, prevents rubbing and secures the lower part of the cycle. On removing the pin s, the cycle may be turned into a horizontal position. The parts of the stand may be pivoted together so that the stand may be folded into the position shown in Fig. 3. In a modification, the arms c are secured on the upper end of the upright a.
Patent GB-189801713-A (GB)
Title: An Improvement in Brick Drying Apparatus.
Inventor: TATTERSALL WILLIAM
Filed: 1898-01-21
Granted: 1898-03-26
Abstract: 1713. Tattersall, W. Jan. 21. Drying furnaces or kilns. -Newly-moulded bricks are first heated by closing the lateral apertures in the walls of the chambers G, and then dried by admitting furnace gases and hot air through the same apertures from channels I or J arranged as shown in Figs. 3, 6, and 7 and having doors K, L which may assume the positions shown in full lines or those shown in dotted lines. At first the valves controlling the lateral apertures W and a valve in the chimney are closed, so that hot furnace gases are drawn by the fan B and pass through the channel E to channels under the chambers G by means of doors F and, after circulating through the channels I or J, are forced to return to the furnace. When the bricks are sufficiently heated to prevent cracking, the lateral ports W are uncovered, and the valve in the chimney is opened so that the hot gases &c. pass to and from the chambers G as indicated by arrows in Fig. 3, and the moist gases finally escape by the channel M and a shaft, not shown, to the chimney.
Patent GB-189806387-A (GB)
Title: Improvements in the Method of and in Machinery for Milling the Bolsters of Cutlery, applicable also for other purposes.
Inventor: PEACH CHARLES
Filed: 1898-03-16
Granted: 1899-03-04
Abstract: 6387. Peach, C., [Johnston, A.]. March 16. Milling.-In a machine for milling the bolsters of knives, or other cutlery or articles, the cutter E, Figs. 1 and 4, is carried by a spindle D mounted in a block C, pivoted at c in a longitudinal recess in a cylinder B. The cylinder is slowly rotated in a casing A<2> by annular differential gearing G, g, I<2> driven from fast and loose pulleys K, K' mounted on a shaft H rotating in the cylinder. The cutter spindle is driven by pinions d, h from the shaft H. The casing A<2> is mounted on a suitable pedestal A'. The knife X is clamped between jaws S, S' on a plate R and adjusted by a gauge U, its blade projecting into a slot C' in the block C. The plate R is carried by a spindle M mounted in an arm L on the casing, and having a lever N with a hooked end n<1>. The lever N is moved by a treadlelever &c. P in connection with the belt fork Q. When the machine is started by shifting the belt to the pulley K, the lever N is depressed and held by a spring latch. This brings the bolster into contact with the cutter and the cylinder B makes one revolution, milling the edge and cutting the groove in the bolster. A lug on the cylinder end then releases the latch, the lever N is thrown up by a spring o, and the machine stopped. The cutter is formed to suit the particular shape required, and has a plain disc E<1> which revolves in contact with the knife handle or a pattern placed on the tang. This determines the pattern, and irregularities are allowed for by supporting the block C on its pivot by a spring c' fixed on the cylinder B, which yields to prevent excessive removal of material. Fig. 5 shows a machine for milling the curved surface of the bolster. The knives 18 are clamped in position on a work-holder 5 carried by a worm-wheel 10, rotating on a standard 3. The cutters 23, 24 are carried by spindles 26, mounted in blocks 32, 33, pivoted at 34 in a casing 6 and pressed together by springs 44. The work-holder is rotated by a worm shaft and carries the knives successively between the cutters. Guiding-discs 30, 31 are fixed to the cutters as before, and the springs 44 yield to prevent excessive removal of material. The cutter spindles are driven by bevel gearing from a fast and loose pulley shaft 40. Slight modifications may be made in the arrangement of the cutters and work-holder.
Patent GB-189809311-A (GB)
Title: Improvements in Lace and other Trimmings.
Inventor: SCHWARZ PHILIPP
Filed: 1898-04-22
Granted: 1898-07-02
Abstract: 9311. Schwarz, P. April 22. Ornamenting fabrics.-A groundwork a of lace or other trimming woven on a suitable loom is ornamented by sewing on it pieces of velvet, silk, leather, or gold material e, Fig. 1, cut out by means of cutting-moulds. Perforations b of the ground may be covered with net of gold fibre &c. d. Cords e, Fig. 2, strings of pearls, pearls, gimp, or buttons may be used as additional ornaments, and the cords, edges of perforations, or the edges of the applied pieces may be sewn or hemmed.
Patent GB-189816958-A (GB)
Title: Improvements in or relating to Driving Gear for Cycles.
Inventor: LOFTS EZRA
Filed: 1898-08-05
Granted: 1899-08-05
Abstract: 16,958. Lofts, E. Aug. 5. Driving-mechanism; safety wheels and supports; brakes; treadle-levers. -The invention is shown as applied to a bicycle, but is stated to be applicable to tricycles &c. Similar mechanism is arranged on the opposite side of the cycle. Each treadle-lever F<2>, pivoted at D on a fork E', carries a frame F<6> fitted with a series of pawls F<8>, arranged so that only one pawl can act at a time. The pawls actuate a ratchet-wheel C, an internal ring of teeth on which gears with a pinion B on the wheel axle. In the case of carriers &c. the pawls may directly actuate ratchet-wheels on the axle. The levers F<2> are channel-shaped and are fitted with pneumatic treads. They are preferably fitted with returning-springs L, but may be connected by a cord passing over a pulley to ensure alternate action. Each lever F<2> is extended forwards to carry a roller G fitted with a pneumatic tyre upon which a brake block H is arranged to act. By depressing the levers the rollers G are caused to bear on the ground so as to act as supports and prevent side-slip. The lever may be held on the ground by an arm M hinged to the frame. The brake H is applied by the rider's foot acting on the lever H<1>. In a modification, pneumatic brakes are fitted to the rollers G and are applied by foot pressure forcing air out of air chambers mounted on the treadle-levers F<2>.
Patent GB-189819067-A (GB)
Title: Improvements in Capsules or Receivers for Containing Liquefied or Highly Compressed Gases.
Inventor: READ HARRY VAUGHAN RUDSTON
Filed: 1898-09-07
Granted: 1898-10-08
Abstract: 19,067. Read, H. V. R. March 7, [date applied for under Sec. 103 of Patents &c. Act, A.D. 1883]. Storing under pressure, capsules for. The closing- cap b is supported during filling by a shoulder a' formed on the top a of the capsule as shown in Figs. 1, 5, and 9, or by a rod or a support a<1*>, Fig. 10, which rests on the bottom of the capsule. The cap is secured by turning the edge a<2> of the capsule over . a vulcanite washer c, leaving some clearance between the flange b<1> of the cap and its support; so that, by pressing the cap inwards, the gas may escape past it. The edge of the flange b<1> is left rough as it leaves the press to facilitate the passage of the gas ; and the crown b<2> of the cap is made thin to act as a safety-valve.
Patent GB-189822193-A (GB)
Title: Improvements in Ore Concentrators.
Inventor: THOMPSON WILLIAM PHILLIPS
Filed: 1898-10-21
Granted: 1898-12-03
Abstract: 22,193. Thompson, W. P., [Bartlett, F. L.]. Oct. 21. Washing ores.-Relates to the class of ore concentrators known as "shaking tables." Fig. 1 shows an end elevation. The table B is shaken by means of an eccentric i, the eccentric-rod k is connected with the table bv rubber buffers. and the motion is controlled by means of nn adjustable rod r connected to the frame A by a spiral spring q. The table B is provided with a series of riffled shelves C, C one above the other, and water is supplied across each shelf. Waste and unconcentrated material is delivered over the side of each shelf through the spout E to the next lower one. The separated material passes over the ends of the shelves C into a suitable grading-box.
Patent GB-189902294-A (GB)
Title: New or Improved Solution for Treating Silk, Silk Waste, Wool and like Materials and Fabrics, for the purpose of Eradicating Hairs and Similar Foreign Substances.
Inventor: HILTON FREDERICK
Filed: 1899-02-01
Granted: 1899-05-06
Abstract: 2294. Hilton, F. Feb. 1. Fibres and yarns, treating.-Relates to a solution for treating silk, silk waste, wool, and other material or fabric for the purpose of removing hairs &c. therefrom. The solution is obtained by mixing solutious of silicate of soda and peroxide of hydrogen, in the proportions of one part of the former to two of the latter. For treating waste silk, four gallons of the mixture are added to the vat for every hundred pounds of waste silk, the material being boiled for about an hour. In the case of silk, wool, &c., about four gallons of the mixture are mixed with one hundred gallons of boiling water in the vat, in which the material is soaked for about six hours.
Patent GB-189906348-A (GB)
Title: Treatment of Distillery Refuse commonly called "Pot Ale" or "Burnt Ale".
Inventor: STORER THOMAS
Filed: 1899-03-23
Granted: 1899-11-25
Abstract: 6348. Storer, T., and McAlley, R. March 23. Foul waters, treating; precipitants and reagents generally; fertilizers.-Distillery refuse, commonly called pot-ale or burnt-ale, may be nearly neutralized by means of milk of lime and evaporated down so as to obtain a residue which may be employed as a fertilizer. The evaporation may be effected in shallow pans heated by means of a fire.
Patent GB-189909557-A (GB)
Title: Improvements in Anchors.
Inventor: PAUL STANLEY CHARLES
Filed: 1899-05-06
Granted: 1900-01-27
Abstract: 9557. Paul, S. C. May 6. Anchors.-The head and arms are made in one piece, which has a sector-shaped hole through it to receive the shank. The ends of this hole make an angle of about 42‹ with the axis of the shank, on which are formed projections c<1>, c<2> bearing on shoulders in the sides of the hole. As shown in Fig. 5, the forward end of this hole is closed when the anchor is atrip ; any matter which may have previously entered is washed out through an opening e<5> in the covering-plate E. In place of a single plate E, two may be used, with a narrow opening between.
Patent GB-189910348-A (GB)
Title: Improvements in Match Receptacles for a Variety of Important Uses, such as the Vending and Distributing of Matches.
Inventor: TAYLOR ISAIAH HENRY
Filed: 1899-05-16
Granted: 1899-08-05
Abstract: 10,348. Taylor, I. H. May 16. Match receptacles. -A receptacle for delivering matches singly is provided with a series of vertical compartments 3, beneath each of which is a recessed roller 12 fitted with an operating-key 19. The ends of the compartments 3 are preferably enlarged. The compartments may be enclosed by a casing having a glass front 8 and standing upon a base-plate 11, which is formed with slots registering with the compartments 3 ; the casing is preferably locked to an upright 2, forming part of, or attached to, the base 1 of the receptacle. When one of the keys 19 is depressed, a match is transferred by the corresponding roller 12 to an inclined chute 25 ready for use, and, when the key is released, the roller is returned to its original position by a spring 17. The compartments 3 may be cast in one piece with the upright 2, or the upright and compartments may be built up of sheet-metal sections. In a modified form of receptacle, a series of slides arranged beneath the compartments is used instead of the rollers 12.
Patent GB-189918358-A (GB)
Title: Improvements in Rotary Engines.
Inventor: WIDMAN ALBERT
Filed: 1899-09-11
Granted: 1899-12-30
Abstract: 18,358. Widman, A., and Baker, J. C. Sept. 11. Annular-chamber type.-Steam, air, &c. acts between the end of a cam 24 and wings 8 sliding in radial recesses in the piston core 5 and side plates 17, and pressed outwards by springs 10 embracing guide-rods 11. The wings 8 have webs 13, which, after being pressed inwards by the cam 24, engage a roller 27 and allow the gradual return of the wings to the cylinder 6. In the case of large engines, additional guides 16 and springs 14 may be provided. Steam or air compressed between the exhaust 25 and the roller 27 prevents the escape of motive fluid. A relief or gauge cock 26 is provided. The inlet 23 is controlled by a valve 28, the operating-lever of which is actuated by an eccentric on the engine shaft 4, the connection between the lever and the eccentric rod being adjustable to vary the expansion of the motive fluid.
Patent GB-189918473-A (GB)
Title: Consolidated Charges for Gazogenes and Seltzogenes.
Inventor: BROWN SIDNEY
Filed: 1899-09-13
Granted: 1899-11-18
Abstract: 18,473. Brown, S. Sept. 13. Gasogenes and seltzogenes; beverages, materials for.-Charges for gasogenes and seltzogenes are made of tartaric or other acid mixed in molecular proportions with sodium bicarbonate. The mixture is consolidated into a tablet by pressure.