Patent EA-004044-B1 (EA)
Title: Ambroxol-containing lozenge
Inventor: MARZ FRIEDER
IPC: A61K31/135
Filed: 2000-07-07
Abstract: 1. Tablet for sucking containing ambroxol, based on sugar alcohols as the matrix material, characterised in that it contains a pharmaceutically acceptable laminar silicate and a polyethyleneglycol optionally together with other pharmaceutical excipients, taste enhancers or flavourings. 2. Tablet for sucking containing ambroxol according to claim 1, characterised in that the laminar silicate is talc. 3. Tablet for sucking containing ambroxol according to claim 1 or 2, characterised in that the content of laminar silicate is in the range from 5 to 100 mg, based on a total mass of the tablet of 1.5 g. 4. Tablet for sucking containing ambroxol according to claim 3, characterised in that the content of laminar silicate is in the range from 20 to 80 mg. 5. Tablet for sucking containing ambroxol according to claim 4, characterised in that the content of laminar silicate is in the range from 30 to 60 mg. 6. Tablet for sucking containing ambroxol according to claim 5, characterised in that the content of laminar silicate is 60 mg. 7. Tablet for sucking containing ambroxol according to one of claims 1 to 6, characterised in that the content of ambroxol hydrochloride is in the range from 1 to 50 mg, based on a total mass of the tablet of 1.5 g. 8. Tablet for sucking containing ambroxol according to claim 7, characterised in that the content of ambroxol hydrochloride is in the range from 5 to 30 mg. 9. Tablet for sucking containing ambroxol according to claim 8, characterised in that the content of ambroxol hydrochloride is in the range from 10 to 25 mg. 10. Tablet for sucking containing ambroxol according to one of claims 1 to 9, characterised in that the polyethyleneglycol has a molecular weight in the range from 3,500 to 20,000. 11.Tablet for sucking containing ambroxol according to claim 10, characterised in that the polyethyleneglycol has a molecular weight in the range from 4,000 to 12,000. 12. Tablet for sucking containing ambroxol according to claim 11, characterised in that the polyethyleneglycol has a molecular weight of 6,000. 13.Tablet for sucking containing ambroxol according to one of claims 1 to 12, characterised in that sorbitol is used as the matrix material. 14. Tablet for sucking containing ambroxol according to one of claims 1 to 13, characterised in that the sodium salt of saccharine is used as the sweetener. 15. Tablet for sucking containing ambroxol according to one of claims 1 to 14, characterised in that peppermint flavouring is used as the flavouring. 16. Process for preparing a tablet for sucking containing ambroxol according to one of claims 1 to 15, characterised in that the individual components are mixed together using process steps known per se and compressed to form a tablet. 17. Process according to claim 16, characterised in that the tablets are prepared by direct compression. 18. Process according to claim 16, characterised in that the laminar silicate is applied by the compression chamber coating method. 19. Use of the tablet for sucking containing ambroxol according to one of claims 1 to 15 for preparing a pharmaceutical composition with secretion-releasing properties.