Patent SG-11201908713T-A (SG)
Title: Distal anchor apparatus and methods for mitral valve repair
Inventor: D'AMBRA MICHAEL NICHOLAS
IPC: A61B17/00
Filed: 2018-04-06
Abstract: NN 00 O C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 11 October 2018 (11.10.2018) WIPO I PCT omit VIII °nolo OH 110 mioliono oimIE (10) International Publication Number WO 2018/187753 Al (51) International Patent Classification: A61F 2/24 (2006.01) A61B 17/04 (2006.01) A61B 17/34 (2006.01) A61B 17/00 (2006.01) (21) International Application Number: PCT/US2018/026570 (22) International Filing Date: 06 April 2018 (06.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/482,468 06 April 2017 (06.04.2017) US (71) Applicants: HARPOON MEDICAL, INC. [US/US]; 351 West Camden Street, Suite 801, Baltimore, MD 21201 (US). UNIVERSITY OF MARYLAND, BALTIMORE [US/US]; 620 W. Lexington Street, 4th Floor, Office Of Technology Transfer, Baltimore, MD 21201 (US). (72) Inventors: D'AMBRA, Michael Nicholas; 4302 East Pa- lo Verde Drive, Phoenix, AZ 85018 (US). CORTEZ, Feli- no V., Jr.; Edwards Lifesciences, One Edwards Way, Le- gal Department, Irvine, CA 92614 (US). GAMMIE, James S.; 2207 Wiltonwood Road, Stevenson, MD 21153 (US). WILSON, Peter; 46 Wolf Hollow Lane, Killingworth, CT 06419 (US). EPSTEIN, Stephen; Edwards Lifesciences, One Edwards Way, Legal Department, Irvine, CA 92614 (US). COURNANE, Stephen; Edwards Lifesciences, One Edwards Way, Legal Department, Irvine, CA 92614 (US). ETHERIDGE, Julie Marie; Edwards Lifesciences, One Edwards Way, Legal Department, Irvine, CA 92614 (US). BOYD, Peter; Edwards Lifesciences, One Edwards Way, Legal Department, Irvine, CA 92614 (US). (74) Agent: HO, Pui Tong et al.; Edwards Lifesciences, One Edwards Way, Irvine, CA 92614 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: DISTAL ANCHOR APPARATUS AND METHODS FOR MITRAL VALVE REPAIR .973-\" . I tot. t it . • • I. FIG. 34AA (57) : Described herein are devices and methods for mitral valve repair. The devices and methods implant a plurality of distal anchors at an annulus of the mitral valve (e.g., the posterior annulus) and tension artificial chordae to pull the portion of the annulus toward an opposite edge and inward into the ventricle. This can effectively reduce the size of the orifice and increase coaptation. The anchor points of the artificial chordae can be offset from the apex of the heart to achieve a targeted force vector on the annulus. In addition, some embodiments include distal anchors implanted in the posterior leaflet in addition to those at the posterior annulus. This allows differential tensioning to be applied to provide for greater flexibility in treating various configurations of mitral valves to improve coaptation. [Continued on next page] WO 2018/187753 Al MIDEDIMOMMIDEFIE31MOBEEIDINDEVOIS Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))