Patent SG-11201807783U-A (SG)
Title: Mutant bordetella strains and methods for use
Inventor: Solans Luis
IPC: A61K9/00
Filed: 2017-03-29
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11M1111101110101011111 HO 11111 01110111100111 11111001111111101111011# International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... .....!;,' WO 2017/167834 Al 5 October 2017 (05.10.2017) IN I PO I P CT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 35/00 (2006.01) A61P 11/00 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 9/00 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/EP2017/057468 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 29 March 2017 (29.03.2017) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 62/314,843 29 March 2016 (29.03.2016) US (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (71) Applicants: INSTITUT PASTEUR DE LILLE [FR/FR]; GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 1 me du Professeur A. Calmette, BP 245, 59019 Lille Ce- TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, dex (FR). INSTITUT NATIONAL DE LA SANTE ET TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DE LA RECHERCHE MEDICALE (INSERM) DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, [FR/FR]; 101, Rue de Tolbiac, Cedex, 75654 Paris (FR). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventors: SOLANS, Luis; 21, Rue Gay Lussac, Apt. 61, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). 59110 Le Madeleine (FR). LOCHT, Camille; Institut Pas- teur de Lille, 1, me du Prosfessor A. Calmette, BP 245, Published: 59019 Lille Cedex (FR). TSICOPOULOS, Anne; Institut — with international search report (Art. 21(3)) Pasteur de Lille, 1, me du Prosfesseur A. Calmette, BP 245, 59019 Lille Cedex (FR). AIT YAHIA SENDID, Sa- — with (an) indication(s) in relation to deposited biological liha; Institut Pasteur de Lille, 1, rue du Professeur A. material furnished under Rule 13bis separately from the Calmette, BP 245, 59019 Lille Cedex (FR). description (Rules 13bis.4(d)(i) and 48.2(a)(viii)) Agents: KILBURN & STRODE LLP et al.; 20 Red Lion — with sequence listing part of description (Rule 5.2(a)) = (74) Street, London WC1R 4PJ (GB). 1-1 7r M GC IN 1-1 (54) Title: MUTANT BORDETELLA STRAINS AND METHODS FOR USE 1-1 C (57) : A method of reducing or preventing the development of airway inflammation in a subject includes the step of infect - ei ing the respiratory tract of a subject an amount of a composition including a pharmaceutically acceptable carrier and live attenuated en. ) pertactin-deficient Bordetella bacteria sufficient to colonize the respiratory tract of the subject. The step of infecting the subject with the live attenuated pertactin-deficient Bordetella bacteria results in reduction or prevention of the development of airway inflamma- tion in the subject.