baber/WOPTO huggingface dataset:
Patent DO-P2022000189-A (DO)
Title: [1,3]DIAZINO[5,4-d]PIRIMIDINAS COMO INHIBIDORES DE HER2
Inventor: BIRGIT WILDING
IPC: C07D519/00
Filed: 2022-09-14
Abstract: La presente invención se refiere a [1,3]diazino[5,4-d]pirimidinas novedosas y derivados de la Fórmula (I)  en donde los grupos R1, R2, R3 y R4 tienen los significados que se proporcionan en las reivindicaciones y la memoria descriptiva, su uso como inhibidores de HER2 y sus mutantes, composiciones farmacéuticas que contienen tales compuestos y su uso como medicamentos, especialmente como agentes para el tratamiento y/o la prevención de enfermedades oncológicas.
Patent EE-200000210-A (EE)
Inventor: PEARLMAN BRUCE A
IPC: C07D263/24
Filed: 1998-10-13
Abstract: The present invention includes a number of novel intermediates such as the (S)-secondary alcohol of formula (VIIIA) X 2 -CH 2 -C*H(OH)-CH 2 -NH-CO-R N  and processes for production of pharmacologically useful oxazolidinones.
Patent GB-189701957-A (GB)
Title: Improvements in Pen Holders.
Inventor: HINCHLIFFE WILLIAM
Filed: 1897-01-25
Granted: 1897-04-17
Abstract: 1957. Hinchliffe, W. Jan. 25. Penholders.-The barrel B is formed with a slot C to facilitate the removal of the nib. The sides D of the slot are beaded, and projections E prevent the nib from being pushed in too far.
Patent GB-189704303-A (GB)
Title: Improvements in Chains and Chain-wheels.
Inventor: GARIN MOISE
Filed: 1897-02-17
Granted: 1898-01-08
Abstract: 4303. Garin, M. Feb. 17. Chain gearing.-The pitch of the driving-wheel is made larger, and that of the driven wheel smaller, than that of the chain, so that the teeth come into action only just as the chain is leaving the respective wheels. The spaces between the teeth are divided into two parts of different radii, whereby, upon reversing the wheels upon their axles, slackness of the chain is taken up.
Patent GB-189705177-A (GB)
Title: Improvements in Air Valves for Pneumatic Tyres, Pneumatic Hubs, and Compressed Air Cushions.
Inventor: WATSON ROBERT GOW
Filed: 1897-02-26
Granted: 1898-02-19
Abstract: 5177. Watson, R. G., and Fyfe, P. Feb. 26. Inflating-apparatus for air cushions.-An inflating-valve for compressedair cushions is shown in section. Fitting airtight within the casing B is a rubber or similar rod-like valve V, the rounded end V<1> of which normally bears on the valve seat 0 formed in the recessed end M of the thimble S screwed on to the casing. The valve is held on the seat by the screwed plug P, which is originally screwed to give an airtight joint between the valve and its seat. To inflate, the cap D is replaced by the coupling y, which has a screwed part U receiving the inflator. The nose-piece x temporarily lifts the valve from its seat 0, and thus allows the air to pass from the inflator through the grooves g, H into the inflated article.
Patent GB-189707525-A (GB)
Title: Improved Means or Method of Effecting the Lubrication of Journals and other Parts of Motive Power Engines.
Inventor: RICHARDSON JOHN
Filed: 1897-03-23
Granted: 1898-01-22
Abstract: 7525. Richardson, J., and Wansbrough, W. D. March 23. Lubricating crossheads, cranks, eccentrics, and other parts of engines. Oil collecting in the reservoir A is filtered by a strainer, and is pumped into the reservoir B, in which it is maintained at a constant pressure. Pipes C from the reservoir lead to the crosshead guides. The crosshead slipper is of a length greater than its stroke, and has holes situated at each end into which the lubricant is forced each time the motion is reversed. These holes communicate with the pipe E leading to the crosshead pin, and a further pipe F leads to the crank. Additional pipes G lead to the valve spindle guides and eccentrics, and pipes K carry lubricant to the shaft bearings. Vaseline or other material may be employed in place of oil.
Patent GB-189707804-A (GB)
Title: Improvements in the Production of Blocked Leather Seats for Cycle and Analogous Saddles.
Inventor: MARTIN PATRICK ALPHONSUS
Filed: 1897-03-26
Granted: 1898-02-26
Abstract: 7804. Martin, P. A. March 26. Embossing and stamping. - Relates to the manufacture of blocked leather seats for cycle and analogous saddles. A leather blank cut to the exact size and softened by moisture is placed upon the die or pressure plate c, which is bolted to the stem c<1> working through a sleeve c<2> and kept to its work by means of the balance weights c<10>. A lever f pivoted at f<1> to a bracket f passes over the plate c<6>, and is retained in position by suitable stops and so controls the movement of the stem c<1>. The die a is connected by a screw coupling a<1> to a carrier a<2>, which is raised or lowered by means of the hand-operated screw d working through a screw box d'. A fixed she-die b supported by stands b<1> is bolted to the bed-plate, an opening b<2> being provided for the removal of the finished seat. The blank g, Fig. 4, is first pressed between the he-die a and the pressure plate c, after which they descend together through the fixed die b, whereby the required shape is imparted to the leather blank. After descending through the fixed die the upper die is returned and the pressure plate kept in position by the stoplever f until the seat has been removed through the opening b<2>. If desired, the pressure plate and the he-die may be stationary and the blocking effected by means of a movable she-die, in which case the pressure plate and the he-die may be connected together by a bolt. Another form of he-die is described made in two parts, which are hinged together at one end and yieldingly connected by a spring and bolt at the other end.
Patent GB-189708854-A (GB)
Title: Improvements in Cycle Saddle Attachment Clips.
Inventor: COWAN ROBERT OSBORNE
Filed: 1897-04-07
Granted: 1898-03-05
Abstract: 8854. Cowan, R. O. April 7. Saddle clips.-A clipping-ring b for taking upon the saddle pin is provided with trunnion ends b<1>, whilst the walls of the ring are split as at b<2>. The shanks b<3> of the trunnions are conoidal in shape, and have washers d with corresponding holes d'. Outer washers e are provided, and the washers are provided with grooves e<1> for receiving the saddle framing rods g. Nuts h take upon the screwed ends of the stalk, and by tightening up the nuts the saddle frame is firmly clamped in the grooves, and the splits in the ring are contracted so that the ring binds firmly upon the saddle pin. The washers carrying the frame wires admit of the tilt of the saddle being adjusted. The ring may be made of half-round section wire bent into suitable shape. The inner washer of each pair need not revolve. Modifications are described, in one of which U-shaped clips take the place of the pairs of washers, and in another the outer washers are omitted. Independent means of contracting the ring b may be employed if desired.
Patent GB-189711732-A (GB)
Title: Improvements in the Treatment or Manufacture of Fodder for Horses.
Inventor: POTT EMIL
Filed: 1897-05-11
Granted: 1897-10-30
Abstract: 11,732. Pott, E., and Kraker, G. May 11. Food for animals.-Relates to a composition prepared in the form of compressed cakes as a food for horses. The composition comprises the seeds of various plants in various forms such as maize, locust beans, malt germs, linseed cake, and bran, together with bulky vegetable materials such as maize cobs and with spices or appetizing substances. In the process of manufacture the materials when mixed may be saturated with certain saccharine or saline solutions before being compressed into cakes.
Patent GB-189718002-A (GB)
Title: Manufacture of Green and Blue-green Colouring Matters from Triphenylmethan.
Inventor: IMRAY JOHN
Filed: 1897-07-31
Granted: 1898-06-11
Abstract: 18,002. Imray, J., [Soc. Anonyme des MatiÞres Colorantes et Produits Chimiques de St. Denis]. July 31. Dyes, artificial.-Green and blue-green dyes of the triphenylmethane series are produced by first converting m-nitrobenzaldehyde, or a homologue thereof, into an amido-sulphonic derivative by hoiling it with a solution of sodium sulphite for about two hours, while a current of carbonic acid is being passed through the mixture. Sulphuric acid and a secondary or tertiary amine, such as dimethyldiethyl- or dibenzyl-aniline, or monomethyl-, monoethyl-, or monobenzyl-o-toluidine, or a sulphonic acid of ethylbenzyl-, methylbenzyl- or dibenzylaniline, are added to the mixture, which is then boiled at the reflux condenser. After removal of the excess of amine the leuco compound produced is precipitated and then oxidized to the dye-stuff in the usual manner. Sulphonation of the leuco compounds, instead of the free m-nitro-benzaldehyde by sodium sulphite, gives inferior results.
Patent GB-189719881-A (GB)
Title: Improvements in Apparatus for Heating Water.
Inventor: PALMER THOMAS CASSIENET
Filed: 1897-08-28
Granted: 1898-02-05
Abstract: 19,881. Palmer, T. C. Aug. 28. Mixing-valves.-A mixing-chamber a is provided with an annular water inlet b and a central steam inlet c, both controlled by a screw-down valve d, so that, when the valve is raised, water and steam enter the mixing-chamber and the condensed steam and water afterwards escape past a perforated sleeve k to the outlet d. An adjustable plug j regulates the steam opening, and the valve is provided with a renewable face e, preferably of asbestos.
Patent GB-189724190-A (GB)
Title: A Sharpener for Pencils and the like.
Inventor: WOOD JOHN
Filed: 1897-10-20
Granted: 1898-10-20
Abstract: 24,190. Wood, J. Oct. 20. Pencil sharpeners; pencil point protectors. - A pencil sharpener B is provided in a tubular piece A such as a point protector, which may be carried on the pencil. The sharpener consists of a piece of metal B having a V-shaped recess, the edges c of which are roughened or fluted to sharpen the lead of the pencil. The piece B may be made in two parts riveted together. A passage d may be provided for the escape of the cuttings.
Patent GB-189728972-A (GB)
Title: Improvements in Grid Iron Exhaust Valves for the Cylinders of Steam Engines and in Mechanism for Actuating such Valves.
Inventor: HOYOIS ALFRED
Filed: 1897-12-07
Granted: 1898-03-26
Abstract: 28,972. Hoyois, A. May 8, [date claimed under Sec. 103 of Patents &c. Act, A.D. 1883]. Valves and valve gear.-Relates to the construction of exhaust grid slide valves and gear for operating the same. The valves e, i, which may or may not have grooves in their working faces, and are arranged at the ends of the cylinder, are worked by rods g, k passing through the exhaust passages and connected to the valves by a tenon passing through a slot in the valve seat. The gear by which they are actuated consists of a rocking lever c connected at opposite ends to the two valve-rods, one on each side, and having its arms at such an angle to each other that the valves are nearly at rest when fully open.
Patent GB-189729448-A (GB)
Title: Improvements relating to Bakers' Ovens.
Inventor: POINTON CHARLES EDWARD
Filed: 1897-12-13
Granted: 1898-12-13
Abstract: 29,448. Pointon, C. E., Pointon, J. E., and Lewis, G. Dec. 13. Ovens.-Relates to means for filling ovens with loaves. The loaves are placed on long pivoted shelves A carried on frames mounted on castors or running on rails so as to be run into the oven. The shelves are then released or allowed to fall as shown in Fig. 4, to deposit the loaves on the oven floor.
Patent GB-189730283-A (GB)
Title: Improvements in Pneumatic Tyres for the Wheels of Cycles and other Vehicles.
Filed: 1897-12-22
Granted: 1898-11-19
Abstract: 30,283. Williams, F. A., and Piggott & Co., T. Dec. 22. Tyres, pneumatic; felloes or rims.-A tyre of the tubeless type is shown in section in Fig. 3, the principle of con. structing joints, which is described in Specification No. 13,760, A.D. 1892, being here applied to pneumatic tyres. The rim A has inturned edges a, a' under which take the ridges b, b<1> on the edges of the tyre B. Between the edges of the tyre is an archshaped bridge-piece adapted to form an airtight joint with the inner sides of the edges, and to this bridgepiece is connected the inflating valve which passes through the rim. The bridge-piece may be channelshaped, or it may be permanently connected with one edge of the tyre.
Patent GB-189806145-A (GB)
Title: Process for Hardening and Rendering Tenacious the Active Mass of Electric Accumulators.
Inventor: BARBY RODERICH VON
Filed: 1898-03-12
Granted: 1899-03-04
Abstract: 6145. Barby, R. von. March 12. Secondary batteries.-The active material is hardened and rendered tenacious by mixing it, i.e. red lead, with pure water, half drying the mixture, and then exposing it to the vapours of indigotin, acetic acid, phenol, alizarin, pyroracemic acid, or other organic substance capable of forming compounds with the lead oxide.
Patent GB-189808046-A (GB)
Title: Improvements in and relating to Pince-nez.
Inventor: SALT WILLIAM
Filed: 1898-04-04
Granted: 1899-04-01
Abstract: 8046. Salt, W., [Jacquemin frÞres, J. B.]. April 4. Eyeglasses.-Relates to the type of pince-nez which has an extensible, but otherwise rigid, bridge B with closing-spring D and which may be provided with a finger piece on one member of the bridge for expanding the bridge and placing the glasses on the nose with one hand. The plaquettes E, E are secured at F to the rims A, and at their upper ends to levers or cranks G pivoted on an extension H of the rims. The opposite ends of the cranks are slotted and receive pins projecting from the guide-collars C of the other half of the bridge. From this arrangement it follows that, when the rims A are slightly separated, the plaquettes are swung much more apart.
Patent GB-189810125-A (GB)
Title: Improvements in Machinery for Scutching and Hackling Flax and other Vegetable Fibres.
Inventor: VALLET-ROGEZ FRANCOIS
Filed: 1898-05-03
Granted: 1899-04-29
Abstract: 10,125. Vallet-Rogez, F. May 3. Scutching - apparatus ; heckling - machines. - A scutching-machine and a heckling-machine are combined together so that the material may be passed continuously and automatically from the one to the other, and, after having passed through one combined scutching and heckling machine, the strick holders are passed along a curved guide or railway on to a table, where the strick is reversed in its holder, which is fed into a second similar machine arranged parallel to the first but oppositely, so that both ends of the strick are uniformly treated. The strick holders E are moved intermittently along their rising and falling channel by means of a reciprocating rod F carrying pawls G which engage with the holders, the pawl which transfers the holders from the scutching to the heckling machine having the length of its stroke increased by a system of levers. In order to prevent the holders from being placed in the machine otherwise than in their proper positions, the holders are blocked at the entrance to the channel by a pair of spring bolts V, V<1>, which are moved back alternately by a pivoted catch W on the rod F, the first bolt being released by the catch before the second one V<1> is withdrawn. At the return movement of the rod F, the catch rides over the bolts. Beneath the holders of the scutching-machine the material is broken by means of a reciprocating plate arranged between two pairs of fixed plates, and below these plates the material is cleaned by a pair of rotary heaters J, Fig. 10, of which the blades K have serrated edges and are secured into end plates or discs, which are recessed to receive the edges of a plate or cup for preventing the fibre from being entangled in the bearings. In general arrangement, the heckling- machine is similar to an ordinary heckling-machine, but the first set of heckles are made, as shown in Fig. 15, with vertical knife edges N, which become gradually converted into horizontal knife edges 0, the whole being arranged to penetrate the strick and scrape every part of it.
Patent GB-189814621-A (GB)
Title: Improvements relating to the Lids and Fastenings of Packing Cases.
Inventor: STEINBERG HERMANN
Filed: 1898-07-02
Granted: 1898-09-17
Abstract: 14,621. Steinberg, H. July 2. Fastenings for boxes. The lids of wooden packing-cases are fitted with cross-bars a in which slide fastening bolts or bars b, or an upper and lower lid between which the holts slide may be provided. The fastening-bars are suitably slotted or perforated at the ends to engage with nails c on the edge of the box, and are secured in place by means of screws passed through the cross-bars or lids. In a modification, the fastening- bars may be in two parts sliding end to end as in Fig. 7. In this case hooks c are used in lieu of nails, and the bars b when slid together may be secured by a string, which may be sealed. In a further modification, Fig. 10, one of the bars b serves as a hinge, the end of the other bar being bent to enter a perforation in the box.
Patent GB-189817419-A (GB)
Title: Improvements in Cold Producing Machinery.
Inventor: PETIT LEON
Filed: 1898-08-12
Granted: 1899-02-18
Abstract: 17,419. Petit, L. Aug. 12. Ice-making and refrigerating. -Relates to ammonia absorption apparatus with two absorbers A, A<1>, two evaporators B, B', a double-acting gas pump P, and four singleacting pumps P<1>, P<2>, P<3>, P<4> for liquid. Gas is taken from the evaporator by the pump P to the absorber A. The weak liquid from the evaporator B is transferred to the absorber A<1> by means of the pump P<3>, while the pump P' removes strong liquor from the absorber A to the evaporator B'. The second pair of vessels A', B' are connected by the gas pipe C, which is also connected through a pipe c<1> with the exhaust pipe to the pump P. The other pair of pumps serve to return the liquids in a similar manner to the first pair of vessels, the pipes and cocks being arranged as indicated in Fig. 10. A vertical section of the absorbers A, A' is shown in Fig. 1. The weak liquid from the pipe r' is sprayed by a rose under the gas inlet r, and then is distributed by a perforated plate M over a series of pipes through which cooling-water is circulated. The evaporator has a similar perforated spreading- plate over the pipes through which liquid to be cooled is circulated by a turbine &c., the whole being immersed in a tank L divided by a partition in which valves V are placed. A section of the pump is given in Fig. 5, showing a hollow piston and valves held on their seats by springs. The ice moulds are supported by counterbalanced levers i<1>, which close the water supply valve when they rise.
Patent GB-189821256-A (GB)
Title: Improvements in or connected with the "Long Collars" of the Spindles of Slubbing, Roving, and Intermediate Frames Used in the Spinning of Textile Fibres.
Inventor: DAVENPORT JOHN MASON
Filed: 1898-10-10
Granted: 1899-08-12
Abstract: 21,256. Davenport, J. M. Oct. 10. Spindle apparatus for slubbing, intermediate, and roving frames. In order to reduce the weight of the long collars, the central portions thereof are provided with longitudinal slots b.
Patent GB-189823457-A (GB)
Title: A Device for Cleaning and Lubricating Bicycle and other Vehicle Chains, and like Articles.
Inventor: BALDWIN WILLIAM JAMES
Filed: 1898-11-08
Granted: 1898-12-23
Abstract: 23,457. Baldwin, W. J. Nov. 8. Lubricators. - R e - lates to an appliance for cleaning and lubricating bicycle and other chains &c. The chain is detached and hung over a wheel B mounted in a case A having the upper portion D hinged to it, to enable the chain-wheel &c. to be readily removed. The lower end of the chain projects below the end of the case into a can H hung on pegs f as shown and containing a cleansing- fluid. On rotating the chain-wheel, the dirt &c. is removed, and falls through an opening i<1> in a conical bottom i into a lower chamber, as shown, from which it is removed through the plugged opening K. After cleaning, the chain may be lubricated by replacing the can H by a can containing lubricant and again rotating the wheel B. This can is preferably formed as shown in Fig. 4, with an inner chamber to hold the lubricant and an outer chamber to contain hot water for melting a solid lubricant.
Patent GB-189825860-A (GB)
Title: Improvements in Ironing Machines.
Inventor: BRAITHWAITE CHARLES LLOYD
Filed: 1898-12-07
Granted: 1899-10-28
Abstract: 25,860. Braithwaite, C. L., Braithwaite, I., and O'Brien, E. Dec. 7. Guards for ironing - machines. Fig. 3 shows a sectional side elevation of the machine. The internally - heated ironing-rollers D, E are preferably driven at different speeds by means of suitable toothed gearing, and are protected by a casing H.
Patent GB-189902991-A (GB)
Title: Portable Carrying Bier.
Inventor: NORTHOVER WALTER BAKER
Filed: 1899-02-10
Granted: 1899-12-16
Abstract: 2991. Northever, W. B. Feb. 10. Biers.-Relates to a folding bier, adapted also for use instead of trestles to support the coffin. A frame is formed of side-pieces A connected by cross-pieces B, and brackets G support hand-rails F, preferably of brass tubing Legs C, connected in pairs by wrought-iron &c. stays D, are hinged under the frame, and fitted with rule-joint brackets E, which acts as stays when the legs are in use.
Patent GB-189904903-A (GB)
Title: Improvements in Apparatus for Sterilising Liquids.
Inventor: PIRRIE WILLIAM
Filed: 1899-03-06
Granted: 1900-02-10
Abstract: 4903. Pirrie, W., and Pirrie, N. March 6. Liquids, sterilizing. - Figs. 1 and 3 show apparatus for sterilizing liquids in which the supply of heat and liquid is automatically regulated. The liquid to be sterilized enters by a pipe f and passes through pipes j to alternate concentric cylinders m, where it is warmed while passing upward by the sterilized liquid which is descending in the intermediate cylinders. The liquid is collected at the top by pipes k, and passes through a pipe n to the bottom of a heated chamber a, where it is sterilized. The sterilized liquid passes through a pipe o to the cylinders m, where it is cooled by the unsterilized liquid, and finally passes through pipes g and p and a regulator A to the escape pipe. The chamber a is heated by a burner b, the hot gases passing as shown through a jacket to the chimney c. The regulating-arrangement is shown separately in Fig. 3, and consists of a flexible chamber q which is connected by a pipe r to a tube s immersed in the liquid being sterilized, so that the pressure of the vapour of liquid contained in the tube s may, when the temperature rises, inflate the chamber q, thus opening a liquid supply valve t against the action of a spring u and partially closing a gas regulating-valve w. A fali in temperature reverses this operation. According to the Provisional Specification, the thermostatic regulator may consist of a vessel immersed in the heated liquid and filled with an expansible fluid, the vessel being in communication with a receiver so that, when a portion of the liquid has been expelled by excessive heat, the vessel rises and actuates the regulating-valves.
Patent GB-189904967-A (GB)
Title: An Improved Grinding, Polishing, and Drilling Machine.
Inventor: TATTERSALL ARTHUR ALBERT
Filed: 1899-03-07
Granted: 1900-01-13
Abstract: 4967. Tattersall, A. A. March 7. Drilling.-Fig. 3 illustrates in section a treadledriven machine, which, for drilling, grinding, polishing, or buff- - ing, can be affixed to a bench. The frame of the machine supports the revoluble spindle c, which carries a universal chuck d, emery wheel e, and taper screw c<1>, upon which polishing- wheels &c. may be placed. The spindle is driven by a cord from the wheel k, which is loose on the axis j, and receives its motion through loose ratchets m<2> engaging with teeth upon the inner surface of the box-like extension m upon the wheel k. The ratchets engage the teeth when the wheel 0 is dragged in one direction by the band r attached to a treadle, but are released therefrom on the return stroke of the wheel, the return stroke being effected by the uncoiling of a spring p. Each ratchet is constructed with a pointed front end and a rounded back end.