baber/WOPTO huggingface dataset:
Patent DE-112013004531-B4 (DE)
Title: Bewegbare Vakuumschweissvorrichtung
Inventor: HORI TAKUMI
IPC: B23K15/06
Filed: 2013-07-26
Granted: 2017-10-19
Abstract: Bewegbare Vakuumschweißvorrichtung (1; 1D; 1E), aufweisend: eine Vakuumkammer (7), die einen Randabschnitt (12; 12E) gegenüber einer Oberfläche eines Schweißzielobjekts (T; T2) aufweist und einen Vakuumraum zwischen der Oberfläche des Schweißzielobjekts (T; T2) und der Vakuumkammer (7) bildet, einen Dichtungsabschnitt (8), der zwischen dem Randabschnitt (12; 12E) und dem Schweißzielobjekt (T; T2) über den gesamten Umfang des Randabschnitts (12; 12E) angeordnet ist, einen Schweißkopf (9), der konfiguriert ist, um ein Schweißen auf der Oberfläche des Schweißzielobjekts (T; T2) in dem Vakuumraum (7) durchzuführen, eine Bewegungseinheit (2), die konfiguriert ist, um das Schweißzielobjekt (T; T2) mit Bezug auf die Vakuumkammer (7) relativ zu bewegen, und eine Vorlasteinheit (10), die konfiguriert ist, um eine Last auf den Dichtungsabschnitt (8) im Voraus anzuwenden, wobei der Dichtungsabschnitt (8) ein erstes Dichtungselement (27) umfasst, das sich entlang dem Randabschnitt (12; 12E) erstreckt, dadurch gekennzeichnet, dass das erste Dichtungselement (27) aus einem elastischen Material gebildet ist, und der Dichtungsabschnitt (8) ein zweites Dichtungselement (28) aufweist, das zumindest an einer Rückseite in der ...
Patent DE-112014003094-B4 (DE)
Title: Treibtrommeltrieb
Inventor: KNOBLOCH CHRISTIAN
IPC: F16H55/50
Filed: 2014-07-01
Granted: 2020-12-03
Abstract: Treibtrommeltrieb, aufweisend eine Treibtrommel (2) mit daran angeordneter Einrichtung zur Ausbildung einer axial zentrierenden Bewegung einer von der Treibtrommel (2) axial ablaufenden Schlinge (9) eines tangential von der Treibtrommel (2) ablaufenden Zugmittels (4), wobei wenigstens eine Reibschluss zwischen Zugmittel (4) und Treibtrommelumfang herstellende volle Umschlingung (9) des Zugmittels (4) vorgesehen ist, wobei als Einrichtung zur Ausbildung der zentrierenden axialen Querbewegung der von der Treibtrommel (2) ablaufenden Schlinge (9) des Zugmittels (4) ein im Bereich der Schlinge (9) um die Treibtrommel (2) herum angeordneter Führungstunnel (34) vorgesehen ist, der die Schlinge (9) zumindest teilweise am Umfang und über zumindest einen Teil des Querschnitts des Zugmittels (4) an beiden Seiten axial führt und gegen ein Ablaufen von der Treibtrommel (2) sichert, dadurch gekennzeichnet, dass Tangentialplanetenräder (32, 33) als Auflagen für die Schlinge (9) am Umfang der Treibtrommel (2) vorgesehen sind, die eine axiale Bewegung des Zugmittels (4) frei von Gleitreibung ermöglichen.
Patent DE-112014004487-B4 (DE)
Title: Fahrzeug-Klimatisierungsvorrichtung und Fahrzeug-Klimatisierungsverfahren
Inventor: MORISHITA MASATOSHI
IPC: B60H1/32
Filed: 2014-09-24
Granted: 2022-08-25
Abstract: Die Heizleistung des Kühlmittels wird gesteigert, während das Gewicht und die Kosten reduziert werden. Eine Fahrzeug-Klimatisierungsvorrichtung (10) ist mit einem Wärmepumpenkreislauf (16) für den Heizbetrieb ausgestattet, in welchem ein elektrischer Kompressor (50) zur Verdichtung des Kühlmittels, ein Kondensator im Fahrzeuginnenraum (26) und ein Wärmetauscher außerhalb des Fahrzeuginnenraums (54) in der angegebenen Reihenfolge durch eine Kühlmittelleitung verbunden sind. Ein Wechselrichter für den elektrischen Kompressor 50, in dem ein Leistungselement verwendet wird, das aus einem Halbleiter mit hohem Wärmewiderstand besteht, ist so am elektrischen Kompressor (50) angebracht, dass das von diesem verdichtete Kühlmittel vom Leistungselement erwärmt werden kann. Während des Heizbetriebs des Wärmepumpenkreislaufs (16) wird das Kühlmittel vom Leistungselement erwärmt.
Patent DE-112016006332-B4 (DE)
Title: Leistungsmodul
Inventor: YOKOYAMA YOSHINORI
IPC: H01L23/36
Filed: 2016-11-04
Granted: 2021-02-04
Abstract: Leistungsmodul (101), das Folgendes aufweist:- eine isolierte Leiterplatte (1);- ein Halbleiterelement (3), das auf einer Seite auf der einen Hauptoberfläche (1a) der isolierten Leiterplatte (1) angeordnet ist;- eine erste Pufferplatte (5), die zwischen der isolierten Leiterplatte (1) und dem Halbleiterelement (3) angeordnet ist;- ein erstes Verbindungsmaterial (11), das zwischen der isolierten Leiterplatte (1) und der ersten Pufferplatte (5) angeordnet ist;- ein zweites Verbindungsmaterial (11), das zwischen dem Halbleiterelement (3) und der ersten Pufferplatte (5) angeordnet ist; und- ein Wärmeableitkörper (7), der auf einer Seite der anderen Hauptoberfläche auf einer gegenüberliegenden Seite von der einen Hauptoberfläche (1a) der isolierten Leiterplatte (1) angeordnet ist, wobei das erste Verbindungsmaterial (11) in Draufsicht in eine Vielzahl von Bereiche unterteilt ist, und dazu ausgebildet ist, die isolierte Leiterplatte (1) und die erste Pufferplatte (5) zu verbinden,dadurch gekennzeichnet,dass das Material des ersten Verbindungsmaterials (11) ein niedertemperatur-gesintertes Material, ein Flüssigphasen-Diffusions-Verbindungsmaterial oder Lot ist,wobei die erste Pufferplatte (5) einen höheren Längenausdehnungskoeffizienten als das Halbleiterelement (3) und einen niedrigeren Längenausdehnungskoeffizienten als die isolierte Leiterplatte (1) aufweist, wobei die erste Pufferplatte (5) einen niedrigeren Elastizitätsmodul als das Halbleiterelement (3) aufweist,wobei der Längenausdehnungskoeffizient der isolierten Leiterplatte (1) einen Wert von 4,8 × 10-6/°C oder mehr und 14,5 × 10-6/°C oder weniger aufweist, und der Elastizitätsmodul der ersten Pufferplatte (5) geringer ist als 430 GPa.
Patent CH-675340-B5 (CH)
Inventor: GRIMM EDGARDO
IPC: G04B47/06
Filed: 1987-12-18
Abstract: The instrument includes a part housing a pastille which lies in contact with the finger of the user. A visible part of the pastille adopts a different colour according to the state of the user's blood circulation. The instrument also includes a reference chart indicating the stage of the circulation, according to the colour shown. These colours also indicate the general state of stress suffered by the user, ranging from relaxed, through calm and agitated to stressed. USE - Personal health indication.
Patent SK-280742-B6 (SK)
Title: R(+)-n-propargyl-1-aminoindan compunds, process for their preparation, their use, and pharmaceuticals containing them
Inventor: YOUDIM MOUSSA B H
IPC: A61P25/28
Filed: 1991-01-03
Abstract: A process for the preparation of a compound of the formula (I) and acid addition salts thereof, comprising reacting the R(-)-enantiomer of 1-aminoindan with propargyl bromide or propargyl chloride in the presence of an organic or inorganic base, optionally in the presence of a suitable solvent and isolating the R(+)-enantiomer of the N-propargyl-1-aminoindan by chromatography, distillation, selective extraction and, if desired, converting the free base obtained into an acid addition salt thereof. Pharmaceuticals usable in the treatment of Parkinson's disease, memory disorders, dementia of the Alzheimer type (DAT), depression and the hyperactive syndrome, which pharmaceuticals contain R(+)-N-propargyl-1-aminoindan, optionally in combination with Levodopa and decarboxylase inhibitor, e.g. L-Carbidopa or benserazide. The use of the compund of the formula (I) for the preparation of preparations usable in the treatement of the aforementioned dieseases.
Patent SK-282629-B6 (SK)
Title: Process for the preparation of o-demethyltramadol enantiomers
Inventor: BUSCHMANN HELMUT
IPC: C07C213/10
Filed: 1997-01-17
Abstract: Disclosed is a production method of O-demthyltramadol enantiomers, in which the tramadol racemic salt is converted to the base, by the L-(+)-tartaric acid by precipitation the tramadol (-)-enantiomers are separated and after releasing the base are with the help of diisobutyl aluminium hydride converted to the O-demethyltramadol (-)-enantiomer and from the mother liquor is after precipitation by tartaric acid O-demethyltramadol (+)-enantiomer is produced by releasing from the tramadol base and by reaction with diisobutyl aluminium hydride, as well as the use of enantiomers as anodyne.
Patent CZ-281442-B6 (CZ)
Inventor: REIL WILHELM
IPC: B29C51/42
Filed: 1991-02-25
Abstract: Zařízení je určeno pro hluboké tažení misky (8b) z přířezu (8) z hlubokotažné plastické hmoty  nástrojem (16) a opěrnou čelistí pohyblivými relativně vůči sobě. Aby se výkon stroje zvýšil a odpad byl co nejmenší a dále aby se podstatně zlehčila ruční manipulace s pásy z termoplastické hmoty, je jako opěrná čelist upravena hlavní přísavná deska (7b) upevněna na topném hlavním nosiči (6), která je spolu s hlavním nosičem (6) jako podávací topná čelist pomocí zdvíhacího zařízení (37) střídavě pohyblivá ve směru (21)  kolmém k rovině pohybu (20) nástroje (16) na hluboké tažení, že ve vzdálenosti (a) od spodní hlavní přísavné desky (7b) je na hlavním nosiči (6) upevněna alespoň jedna další střední hlavní přísavná deska (7a) jako podávací topná čelist (5), a že vedle nástroje (16) na hluboké tažení je ve vzdálenosti (a) od něj uspořádána rovnoběžně s jeho směrem pohybu (20) střídavě pohyblivá vnější topná čelist (14) s vnějším nosičem (10) a vnější přísavnou deskou (13, 13a)  tak, že vnější ŕ
Patent CZ-296544-B6 (CZ)
Title: Purified and isolated DNA comprising the hamster EF-la transcriptional regulatory DNA, host cells, vectors, chimeric polynucleotides, plasmids, and method for increasing transcription of a gene
Inventor: ALLISON DANIEL S
IPC: C12N15/11
Filed: 1998-05-01
Abstract: In the present invention, there is disclosed a Purified and isolated DNA comprising the hamster EF-la transcriptional regulatory DNA being selected from the group consisting of a) nucleic acid sequence shown in SEQ ID NO: 1, b) a portion of a nucleic acid sequence shown in SEQ ID NO: 1, which is capable of promoting transcription of a gene operatively linked to the regulatory DNA, c) from about nucleotide 2114 to about nucleotide 3656 in the nucleotide shown in SEQ ID NO: 1, d) 11.7 kb of hamster EF-l{alpha} in the pDEF14 plasmid being deposited with the ATCC Collection and assigned Accession Number 98398, e) a nucleic acid sequence set out in SEQ ID NO: 28, f) a hamster EF-la transcriptional regulatory DNA sequence hybridizing with DNA described in SEQ ID NO: 1 under conditions comprising final washing in buffer containing about 2X SSC and about 0.1 percent SDS at a temperature of 65 degC, g) DNA containing about 1.56 kb 5' to the initiating ATG codon in the SEQ ID NO: 1. Disclosed are also host cells, vectors, chimeric polynucleotides, plasmids, as well as a method for increasing transcription of a gene.
Patent CZ-287481-B6 (CZ)
Title: Dyeing process of textile substrates with above critical liquid and apparatus for making the same
Inventor: SCHOLLMEYER ECKHARD
IPC: D06M23/10
Filed: 1996-07-11
Abstract: Textile substrates in the form of yarn packages or a wound-up textile bands are flown with an above critical liquid (12) substantially perpendicular to the package or wound yarn or in this direction the above critical liquid (12) is forced. Treatment temperature during treatment thereof is in the range of 70 to 300 degC, including said extreme temperature values. The process can be also carried out in such a manner that the treatment temperature values are during treatment at least two functions of this treatment period and the above critical liquid (12) conditioning differs is in the instant at which the subsequent function is activated. The apparatus for making the above described process consists of a dyeing autoclave (1), a saturation device (4), a separator (5) a heat-exchange apparatus (3) a condenser (6) and a pump (2) being all interconnected by means of pipes and fittings. The apparatus also comprises a process controller (10) by means of which variable values of the treatment temperature are set.
Patent SK-280884-B6 (SK)
Title: Sulfonamido- and sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-n-oxides, process for their preparation and their use as medicines
Inventor: WEIDMANN KLAUS
IPC: C07D213/81
Filed: 1993-03-22
Abstract: The invention relates to sulphonamido- and sulphonamidocarbonyl-pyridine-2-carboxamides of the general formula (I) and their use as medicines, in particular against fibrotic disorders.
Patent SK-282165-B6 (SK)
Inventor: HILDEBRAND GUENTER
IPC: F28D20/02
Filed: 1993-11-29
Abstract: Akumulátor (1) latentného tepla alebo chladu s tepelnoakumulačným médiom (2) tuhnúcim za vzniku kryštalických štruktúr, ako je parafín, pričom kryštalické štruktúry sú modifikované štruktúrnymi prísadami s modifikačnými účinkami na tieto kryštalické štruktúry, výhodne na vytváranie dutých štruktúr, ako sú napríklad duté kužele.ŕ
Patent SK-282034-B6 (SK)
Title: Keel structure in wraparound packages
Inventor: BAKX MARTINUS
IPC: B65D71/12
Filed: 1993-11-22
Abstract: A keel structure in a wraparound carton comprises a number of keel elements (K) which separate one row of containers from another row within the carton. Each keel element has spaced upstanding panels (P, 32; Pa, 32a) against which containers held in the carton abut. Each of the upstanding panels is spaced from the other by a platform (P1, P1a) defined by curved edges (C, C1; Ca, C1a) extending towards one another permitting adjacent portions of each of said upstanding panel means to be flexed inwardly toward the other to receive a wall portion of an adjacent container.
Patent CZ-290232-B6 (CZ)
Title: Process for preparing mono-N-substituted tetraazacyclododecane and tetraazacyclotetradecane derivatives
Inventor: PLATZEK JOHANNES DR
IPC: A61K49/00
Filed: 1992-12-04
Abstract: The present invention relates to a process for preparing mono-N-substituted tetraazacyclododecane and tetraazacyclotetradecane derivatives of the general formula I, in which the substituents have specific meanings, from tetraazatricyclotridecane, optionally tetraazatricyclopentadecane of the general formula II, wherein the substituents have specific meanings. The preparation process is usable particularly for preparation of larger amounts of the substance. The obtained products are then usable for production of metal complexes intended for diagnostics and therapy.
Patent CZ-282711-B6 (CZ)
Title: Cultivated epidermal transplant
Inventor: BRYCHTA PAVEL MUDR CSC
IPC: A61K35/36
Filed: 1994-05-31
Abstract: This cultivated epidermal transplant, intended for treating burns and dermal defects, can be prepared from the initial embryonic and/or foetal epidermis, which is separable from the dermis, which is fragmented, and the cell suspension obtained is cultivated into at least a one-layer system of a mutually bonded epithelia.<IMAGE>
Patent CZ-292795-B6 (CZ)
Title: Method for underpinning buildings
Inventor: BECK ROLAND
IPC: E02D35/00
Filed: 1996-08-16
Abstract: The invented method for underpinning buildings (1) comprises arranging at least one elongated supporting element (5), preferably a post, substantially parallel to the foundation (2) of a building (1) in a bore (9) performed in advance below the respective building (1) foundation (2).
Patent CZ-288587-B6 (CZ)
Title: Process for preparing 5-amino-2,4,6-triiodoisophthalic acid dichloride
Inventor: CANNATA VINCENZO
IPC: C07C229/62
Filed: 1995-11-24
Abstract: In the present invention there is described a process for the preparation of 5-amino-2,4,6-triiodoisophthalic acid dichloride by chlorinating 5-amino-2,4,6-triiodoisophthalic acid with thionyl chloride in the presence of a suitable solvent and of a tertiary amine salt or quaternary ammonium salt in a molar ratio from 1;1 to 1;2 based on the amount of 5-amino-2,4,6-triiodoisophathalic acid. 5-amino-2,4,6-triiodoisophthalic acid dichloride is an intermediate useful for the preparation of iodinated contrast agents.
Patent CZ-291290-B6 (CZ)
Title: Railway track
Inventor: UNBEHAUN OLAF
IPC: E01B3/40
Filed: 1997-02-17
Abstract: The present invention relates to a railway track comprising a ballast bed (10), with sleepers (12, 62, 64) being transversely arranged on the ballast bed (10) and rails (14) mounted on the transverse sleepers (12, 62, 64). The sleepers (12, 62, and 64) are disposed closely adjoining one another in the track longitudinal direction but out of mutual contact, leaving a gap (140). Each sleeper (12, 62, 64) is provided with at least one drainage channel (33, 68, 70, 134, 160)   extending transversely to the longitudinal direction of the track and intended for lateral water drainage.
Patent CZ-289110-B6 (CZ)
Title: Azabicyclic esters intended for treatment of psychotic disorders and intellectual impairment disorders
Inventor: PACOR JOHN
IPC: A61P25/16
Filed: 1997-02-21
Abstract: In the present invention there are described compounds of the general formula I, in which A represents the group of the general formulae II, III, IV or V and other substituents have specific meanings, further their use for treating or prophylaxis of psychotic disorders and intellectual impairment disorders, such as schizophrenia, mania, manic depression and anxiety, Alzheimer's disease, learning deficit, cognition deficit, attention deficit, memory loss, autism and Attention Deficit Hyperactivity Disorder. The compounds of the invention may also be useful as analgesics in the treatment of pair (including chronic pain) and in the treatment or prophylaxis of Parkinson's disease, Huntington's disease, and Tourette's syndrome, Amyotrophic Lateral Sclerosis and neurodegenerative disorders in which there is dysfunction of the cholinergic system. The compounds may further be indicated for the treatment or prophylaxis of jetlag, for use in inducing the cessation of smoking, and for the treatme
Patent CZ-293243-B6 (CZ)
Title: Chromatographic process for obtaining very pure cyclosporin A and related cyclosporins
Inventor: VOIGT ULLRICH
IPC: C07K7/64
Filed: 1997-03-14
Abstract: The present invention relates to a novel chromatographic process, which is suitable for the purification of cyclosporin-containing crude extracts on industrial scale. In this process, the conventional preparative chromatographic separation methods are completely or at least partially replaced by the Simulated Moving Bed method (SMB). The cyclosporin A obtained in the above-described process satisfies the quality requirements.
Patent CZ-293602-B6 (CZ)
Title: Device for switching switch tongues
Inventor: HEIM ARMIN
IPC: E01B7/02
Filed: 1997-06-10
Abstract: In the invented device for switching switch tongues (12) the tongue tips (13) of which bear against a roller plane of a slide chair (3) secured by a roller pair (6), whereby the front roller (7a) of said roller pair (6) is positioned lower than the rear roller (7b), the roller (7a, 7b) shaft (15) has an eccentric on which there is arranged the front roller (7a).
Patent CZ-288113-B6 (CZ)
Title: Rotor apparatus for a rotary regenerative air preheater
Inventor: FINNEMORE HARLAN EUGENE
IPC: F28D19/04
Filed: 1997-05-09
Abstract: The rotary regenerative air preheater has a rotor mounted to a central rotor post for rotation within a surrounding housing whereby heat absorbent material carried in the rotor is alternately exposed to a flow of heating gas and a gas to be heated. Upper and lower rotor post headers provide means for mounting diaphragms, which divide the rotor into compartments, to the rotor post. The upper rotor post header includes an interior opening for receiving the rotor and an outer peripheral portion having a number of circumferentially spaced T-shaped slots. The upper portion of the inboard end of each diaphragm defines a box-shaped lug which is received in one of the slots. Shoulders defined by the lug engage shoulders defined by the slots to prevent radial movement of the diaphragm. The lower rotor post header is mounted to the rotor and includes a radially extending lower portion that defines a shelf. The lower portion of the inboard end of each diaphragm rests on the shelf such that each diaphragm is supported on the rotor.
Patent CZ-285600-B6 (CZ)
Title: Apparatus for adjusting running
Inventor: PLACHY JAN ING
IPC: B07B1/28
Filed: 1997-12-19
Abstract: The apparatus adjusts the function of a circular sieving machine by means of adjustments of the position of its output shaft (7), which is connected with the upper plate (5), in respect to the position of the input shaft (1), and with the lower plate (3). The plates (3, 5) are connected by non-parallel rods (4) around whose upper pins (6a) the upper plate (5) can be shifted. Between the lower plate (3) and the upper plate there is a bearer (31) with a latchet (71) pressed into its recess. By shifting the upper plate (5), bearing the output shaft (7), around the upper pins (6a) and subsequent clearance adjustment of the latchet (71) in the bearer (31), various degrees of skewing of the output shaft (7) are possible in relation to the input shaft (1) and thus the required "wiggling" movements of the active parts of the machine are achieved. The input shaft (1) is attached to the lower plate (3) by means of a flange (2). An adjustable balance weight (10) is fitted on the lower plate (3) and an upper adjustable balance weight (11) is fitted on the upper plate (5). In the direction towards the latchet (71) shift screws (8) and tilt screws (9) are arranged in the bearer (31). Both the shift screws (8) and tilt screws (9) are arranged opposite one another on perpendicular planes.<IMAGE>
Patent CZ-295784-B6 (CZ)
Title: Piperazine derivatives, pharmaceutical compositions containing such compounds and their use as anti-inflammatory agents
Inventor: BAUMAN JOHN G
IPC: C07D295/185
Filed: 1998-06-11
Abstract: In the present invention, there are disclosed acylpiperazine derivatives of the general formula (Ia), in which Re4 represents -O-, -N(Re7)-, -C(Re8)i2- or a bond, Re5 represents an alkylene chain or an alkylidene chain containing 1 to 8 carbon atoms, or in case the symbol Re4 denotes a bond then the symbol Re5 represents an alkylidene chain having 1 to 8 carbon atoms being optionally substituted with a phenyl or naphthyl group or -N(Re7)i2,  Re6 represents -C(O)-, -C(S)-, -CHi2- or a bond; and Re1a, Re2, Re3, Re7, Re8 have a series of specific meanings. These derivatives are useful as anti-inflammatory agents. The invention also relates to pharmaceutical compositions in which the above-described compounds are comprised as well as the use of these compounds when treating inflammatory disorders in humans.
Patent SK-280049-B6 (SK)
Title: Process for preparing (s)-2-(3-benzoylphenyl) propionic acid
Inventor: WARNECK JULIE B H
IPC: C12P41/00
Filed: 1994-03-03
Abstract: An organism of the genus Ophiostoma or Ceratocystis, or a material having enzymatic activity derived therefrom, is used as a biocatalyst (stereo-specific agent), in a biotransformation reaction, for the production of (S_)-ketoprofen ((S)-2-(3-benzoylphenyl)propionic acid) from a mixture of enantiomers of an ester thereof.
Patent SK-281762-B6 (SK)
Title: Edible plastic spread
Inventor: SASSEN CORNELIS LAURENTIUS
IPC: A23D9/00
Filed: 1996-05-29
Abstract: An edible plastic spread is provided consisting of a continuous fatphase and optionally an aqueous phase wherein the fat of the fatphase includes at most 5 % trans-unsaturated fatty acid residue, consists of 40 - 90 % of liquid oil and 60 - 10 % of structuring fat which structuring fat comprises chemically unmodified palm oil or one or more palm oil fractions or a combination of 2 or more thereof, and includes hydrogenated and/or interesterified fat and/or animal fat such that the amount of interesterified fat is at most 70 % of the structuring fat, contains: at most X % symmetrical POP triglycerides or more than X % symmetrical POP triglycerides and contains asymmetrical PPO triglycerides such that P20 </= 16-4 (POP/PPO) wherein P indicates palmitic acid residues, O indicates oleic acid residues, P20 indicates the sum of POP and PPO triglycerides and X = 3.5, and has an N20 >/= 4.5. In the product substantially no fat particles of a size visible with the naked eye develop upon storage for at least 3 weeks at 5  DEG C.