Patent SG-11201805494W-A (SG)
Title: Mutated von willebrand factor
Inventor: ANDREWS ARNA
IPC: C07K14/745
Filed: 2017-01-06
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111110111101110101011111010111110111011101011111101111101111101111011111 International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/117630 Al 13 July 2017 (13.07.2017) WI P0 I P CT (51) International Patent Classification: (74) Agent: DAVIS COLLISON CAVE; 1 Nicholson Street, CO7K 14/745 (2006.01) A61P 7/04 (2006.01) Melbourne, Victoria 3000 (AU). A61K 38/36 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind PCT/AU2017/050009 AO, BZ, of national protection available): AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (22) International Filing Date: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 6 January 2017 (06.01.2017) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (25) Filing Language: English KP, MD, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (26) Publication Language: English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (30) Priority Data: RU, 2016900033 7 January 2016 (07.01.2016) AU TH, ZA, ZM, ZW. RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (71) Applicant: CSL LIMITED [AU/AU]; 45 Poplar Road, Parkville, Victoria 3052 (AU). (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (72) Inventors: ANDREWS, Arna; C/- CSL Limited, 45 Pop- GM, lar Road, Parkville, Victoria 3052 (AU). PANOUSIS, TZ, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, — Kosta; C/- CSL Limited, 45 Poplar Road, Parkville, Vic- TJ, toria 3052 (AU). EMMRICH, Kerstin; C/- CSL Limited, DK, 45 Poplar Road, Parkville, Victoria 3052 (AU). WILSON, LV, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, — _ Michael; C/- CSL Limited, 45 Poplar Road, Parkville, SM, Victoria 3052 (AU). DOWER, Steve; C/- CSL Limited, 45 GW, KM, ML, MR, NE, SN, TD, TG). Poplar Road, Parkville, Victoria 3052 (AU). HARDY, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Mathew; C/- CSL Limited, 45 Poplar Road, Parkville, Published: . Victoria 3052 (AU). HARTMAN, Dallas; C/- CSL Lim- — with ited, 45 Poplar Road, Parkville, Victoria 3052 (AU). — with international search report (Art. 21(3)) sequence listing part of description (Rule 5.2(a)) = = = = = = = = = 1-1 © M IN 1-1 1-1 IN 1-1 (54) Title: MUTATED VON WILLEBRAND FACTOR 0 ei (57) : The present invention provides a modified polypeptide which binds Factor VIII. The modified polypeptide comprises en. ) a sequence as shown in SEQ ID NO:3 in which the sequence comprises at least one modification at a position selected from the ,7 1 1 . 9 group consisting of L18, V42, K149, N248, S279, V320, T325, Q395 and K418 such that the modified polypeptide binds to Factor VIII with an off rate lower than a reference polypeptide comprising an unmodified SEQ ID NO:3.