Patent SG-11201810701X-A (SG)
Title: Conjugates of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein
Inventor: PETRY STEFAN
IPC: C07K14/62
Filed: 2017-06-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101/110 111010101111101011111 0 011111111111111H1111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2017/207754 Al 07 December 2017 (07.12.2017) WIP0 I PCT (51) International Patent Classification: A61K 47/54 (2017.01) CO7H 19/04 (2006.01) Declarations under Rule 4.17: C07H 13/04 (2006.01) CO7H 19/056 (2006.01) — of inventorship (Rule 4.17(iv)) CO7H 13/10 (2006.01) CO7K 14/62 (2006.01) Published: CO7H 15/12 (2006.01) A61P 3/10 (2006.01) — with international search report (Art. 21(3)) (21) International Application Number: — before the expiration of the time limit for amending the PCT/EP2017/063447 claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (22) International Filing Date: 02 June 2017 (02.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16305640.1 02 June 2016 (02.06.2016) EP (71) Applicant: SANOFI [FR/FR]; 54 me La Boetie, 75008 Paris (FR). (72) Inventors: PETRY, Stefan; c/o Sanofi-Aventis Deutsch- _ land GmbH, 65926 Frankfurt am Main (DE). PLETTEN- BURG, Oliver; c/o Sanofi-Aventis Deutschland GmbH, — 65926 Frankfurt am Main (DE). TENNAGELS, Norbert; c/o Sanofi-Aventis Deutschland GmbH, 65926 Frankfurt = am Main (DE). WERNER, Ulrich; c/o Sanofi-Aventis =_ Deutschland GmbH, 65926 Frankfurt am Main (DE). Agent: ESSLER, Frank; Sanofi-Aventis Deutschland (74) = GmbH, Global Intellectual Property Department, Indus- triepark flochst - K 703, 65926 Frankfurt (DE). _ = Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (81) = = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, = DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = = HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, = KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, = MK, MN, MW, MX, MY MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, = = TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = Designated States (unless otherwise indicated, for every (84) = — kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = — 1-1 71' in EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). IN IN 0 ei N (54) Title: CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE 1-1 SENSING PROTEIN 0 ei (57) : The invention describes novel conjugates of formula (I) of a pharmaceutical agent and a moiety capable of binding to 0 a glucose sensing protein allowing a reversible release of the pharmaceutical agent depending on the glucose concentration.