baber/WOPTO huggingface dataset:
Patent AU-2015271689-C1 (AU)
Title: Expansion and engraftment of stem cells using Notch 1 and/or Notch 2 agonists
Inventor: BERNSTEIN IRWIN D
IPC: C12N5/0789
Filed: 2015-06-03
Granted: 2019-01-17
Abstract: The present disclosure provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, the methods comprising culturing the precursor cells in the presence of a Notch 1 agonist, Notch 2 agonist or Notch 1 agonist and Notch 2 agonist (and, in particular embodiments, one or more growth factors) that support the proliferation but not differentiation of the non-terminally differentiated cells. The present disclosure further provides methods to induce the differentiation of immortalized cells, comprising growing the cells in the presence of a Notch 1 agonist, Notch 2 agonist or Notch 1 agonist and Notch 2 agonist and at least one growth factor which supports the differentiation of the cell into a more specialized cell type. The immortalized and/or differentiated cells of the disclosure can be used to repopulate cell populations that have been diminished, for example as a result of infection or exposure to certain drugs. The disclosure further provides a cell culture comprising a population of non-terminally differentiated cells immortalized by the methods of the present disclosure and kits comprising reagents that promote the immortalization of precursor cells.
Patent AU-2018203508-C1 (AU)
Title: CD33 antibodies and use of same to treat cancer
Inventor: SUTHERLAND MAY KUNG
IPC: A61K39/395
Filed: 2018-05-17
Granted: 2020-09-10
Abstract: CD33 ANTIBODIES AND USE OF SAME TO TREAT CANCER 
ABSTRACT 
The invention provides murine, chimeric, and humanized antibodies that specifically bind to 
CD33. The antibodies are useful for treatment and diagnoses of various cancers as well as 
detecting CD33.
Patent AU-2018354391-C1 (AU)
Title: Methods for renal function determination
Inventor: RAJAGOPALAN RAGHAVAN
IPC: C07D241/20
Filed: 2018-10-26
Granted: 2021-01-21
Abstract: The present disclosure relates to systems and methods for determining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The method includes administering a pyrazine compound of Formula (I) to a patient and monitoring the rate in which the kidneys of the patient eliminate the pyrazine from the systemic circulation of the patient. The pyrazine compound fluoresces when exposed to electromagnetic radiation which is detected using one or more sensors. The rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient.
Patent AU-2019201394-C1 (AU)
Title: Monitoring ground-engaging products from earth working equipment
Inventor: CARPENTER CHRISTOPHER M
IPC: G08B23/00
Filed: 2019-02-27
Granted: 2022-01-13
Abstract: OF THE DISCLOSURE 
A product and system for identifying and monitoring a characteristic including the part ID, 
presence, condition, usage and/or performance of ground-engaging products used on various kinds 
of earth working equipment.
WO 2016/131015 PCT/US2016/017896 
10/22 
196 DB 194 
F22 60 
O 60 38 
60 0 - -' 3 
33 
FIG 1 2 (24
Patent RU-2156357-C1 (RU)
Title: Method of treatment of bottom-hole formation zone
Inventor: BOGOMOL NYJ E I
IPC: E21B43/27
Filed: 2000-02-28
Granted: 2000-09-20
Abstract: FIELD: oil producing industry; applicable in intensification of well productivity. SUBSTANCE: method includes lowering onto bottom hole of container accommodating aluminum capsules filled with alkali or alkali-earth metal, or alloy on its base; contacting of well fluid with alkali or alkali-earth metal, or alloy on its vase; forcing of reaction products into bottom-hole zone. Container is used in form of airtight structure opening on bottom hole. Before loading into container, aluminum capsule are opened. Airtight container is run to bottom hole on cable or wire rope and opened on bottom hole. EFFECT: higher efficiency and technological effectiveness of method. 2 cl, 2 ex
Patent RU-2171168-C1 (RU)
Inventor: DUBROVSKIJ P V
IPC: B24B29/00
Filed: 2000-03-03
Granted: 2001-07-27
Abstract: FIELD: mechanical engineering. SUBSTANCE: workpiece is ground with a flexible tool. The working surface of the tool is covered with an abrasive and not working surface is rigid. The chamber of the tool is filled up with a cutting fluid in a solid state. Ultrasonic vibrations are imparted to the workpiece in direction perpendicular to the axis of rotation of the tool intensifying contact between the tool and the workpiece and making the cutting fluid to be in a liquid state and supplying it to the cutting zone through passages provided in the working surface of the tool. EFFECT: improved conditions of micro-cutting and contact between interacting surfaces, enhanced quality of grinding. 2 cl, 1 dwg
Patent RU-2175975-C1 (RU)
Title: Method of preparing hydrolyzed polyacrylamide for gel-forming compositions
Inventor: BAJBURDOV T A
IPC: C08F220/56
Filed: 2000-03-13
Granted: 2001-11-20
Abstract: FIELD: chemistry of polymer. SUBSTANCE: method comprises preparing reaction mixture containing aqueous solution of acrylamide and alkali metal salts of carbonic acid, deoxidizing, polymerizing acryl amide with combined hydrolysis when heating said reaction mixture using radical type initiators. Prior to deoxidation, prepared reaction mixture is maintained at 25-40 C for 2-4 h. Method makes it possible to prepare composition having gel formation time of 30-60 min. EFFECT: more efficient preparation method. 4 ex, 1 tbl
Patent RU-2177710-C1 (RU)
Title: Method for evaluating cerebrovascular diseases treatment effectiveness
Inventor: MIKHAJLOV V P
IPC: A61B3/024
Filed: 2000-07-17
Granted: 2002-01-10
Abstract: FIELD: medicine. SUBSTANCE: method involves applying computer-aided perimetry to patients having no ophthalmic pathology or eye refraction apparatus threshold sensitivity of the central retina areas, foveal threshold sensitivity and fluctuations are determined before and after treatment. The total threshold sensitivity parameters of the central retina areas increasing by 10% and more, foveal threshold sensitivity increasing by 2% and more, fluctuation parameters reducing by 45 % and more, the treatment is evaluated as effective one. EFFECT: enhanced evaluation accuracy. 5 dwg, 3 tbl
Patent RU-2176847-C1 (RU)
Inventor: GLADYSHEV O M
IPC: H02M7/538
Filed: 2000-10-17
Granted: 2001-12-10
Abstract: FIELD: converter engineering; control systems for fluorescent, mercury, sodium (electronic ballast), and halogen lamps, secondary power supplies. SUBSTANCE: oscillator has power rectifier whose leads are connected to inputs of capacitive divider and also to plus and minus power buses of which one is connected to collector of one of power transistors and other, to emitter of other power transistor; switching transformer incorporating one feedback winding and two identical control windings each of them being connected through one lead to base of respective power transistor and through other, to emitter of respective transistor; current-limiting reactor one of whose leads is connected to output of self-excited oscillator and other one, to load; the latter is connected to center tap of capacitive divider. Control windings of switching transformer are connected in phase opposition to power transistors through diode-capacitor circuits; connected in parallel with feedback winding of switching transformer is blocking capacitor; additional shaping capacitor is inserted between midpoint of divider capacitors and that of power transistors; isolating diodes are inserted in addition into collector circuits of power transistors. Load is connected through current-limiting reactor. EFFECT: enhanced efficiency and safety in operation. 3 dwg
Patent RU-2179631-C1 (RU)
Inventor: LYTKIN A EH
IPC: E21B49/00
Filed: 2001-02-23
Granted: 2002-02-20
Abstract: FIELD: oil and gas industry. SUBSTANCE: first external row of tubing string including packer and body of gear are sunk into well. After leakage check of packer and tubing string by hydrostatic test central row of tubing string is lowered into well into external row of tubing string till it fits body of gear. Location branch pipe having conical outer surface is employed to fit and seal central row of tubing string in body of gear. Calibrated pressure testing plug installed in side inlet conduit of working chamber of gear which is common for all jet-type pumps arranged uniaxially around through conduit in body of gear is employed for pressure testing of external and central rows of tubing string sunk into well and packer. Intake conduits of gear are coupled by common conduit to mixing chamber of jet-type pumps. Gear is equipped with same number of jet-type pumps and non-return valves. Process of acceptance and examination of wells, of intensification of oil and gas inflows, of conducting water-insulation work is realized by way of formation of different variable depressions on pool by use of decrease of seam pressure by evacuation of fluid by jet-type pumps from central row of tubing string coupled to pool and having limited internal volume. Recording measuring equipment can be freely moved in well and in interval of productive pool. EFFECT: improved completeness and quality of operational information, reduced time of acceptance of wells, diminished expenditure of materials, possibility of conducting geophysical, hydrodynamic examinations, treatment of pool and water-insulation work in process of single sinking-lifting utilization of underground well equipment. 4 cl, 7 dwg
Patent RU-2175849-C1 (RU)
Inventor: MURAV EV A V
IPC: A47F10/00
Filed: 2001-04-04
Granted: 2001-11-20
Abstract: Мобильное торговое место для повышения эффективности в пользовании имеет установленные на основании пару неповоротных колес и пару поворотных колес, одно из последней пары несет тормоз для предотвращения несанкционированного передвижения. 5 з.п. ф-лы, 11 ил.
Patent RU-2183038-C1 (RU)
Title: Direct-current electromagnet
Inventor: FOKIN V V
IPC: H01F7/16
Filed: 2001-05-22
Granted: 2002-05-27
Abstract: FIELD: electrical engineering; symmetrical electric drives for actuating mechanisms. SUBSTANCE: dc electromagnet has magnetically permeable case with flanges accommodating coil with two armatures inside the latter. Armatures are isolated from flange and coil and have control rods with ball-type joints at ends for coupling with peripheral load. Apart from that armatures are mounted coaxially relative to one another with aid of alignment unit made in the form of nonmagnetic shaft which is installed for longitudinal displacement in axial holes of each armature on its both ends. EFFECT: enhanced operating reliability. 8 cl, 5 dwg
Patent RU-2195681-C1 (RU)
Title: Facility testing fault of sheets of active steel in cores of stators of ac electric machines
Inventor: GORODOV V V
IPC: G01R31/34
Filed: 2001-06-04
Granted: 2002-12-27
Abstract: FIELD: electrical engineering, diagnostics and test of state of insulation between sheets of electrical sheet steel in cores of stators of AC electric machines. SUBSTANCE: technical result of proposal lies in simplified approach to detection of insulation faults between sheets in core by way of formation in it of alternating magnetic flux with low values of induction. Proposed facility has magnetization winding, variable induction pickup in the form of coil wound on ferromagnetic core and scanning internal surface of core, adjustable power supply unit, measurement unit incorporating phase difference meter and test turn wound around core. Its ends and output of pickup are connected to inputs of phase difference meter. According to first variant output of power supply unit is connected to terminals of magnetization winding and in correspondence with second variant to opposite sides of body of core. In this case one supply wire passes inside core. EFFECT: simplified approach to detection of insulation faults. 2 cl, 6 dwg
Patent RU-2197134-C1 (RU)
Title: Method of preparing nutritious mixture for intraintestinal tube feeding
Inventor: FRAMPOL SKAJA T V
IPC: A23L33/00
Filed: 2001-08-06
Granted: 2003-01-27
Abstract: FIELD: food industry. SUBSTANCE: ground fat, protein and carbohydrate components are mixed with water and mineral additive. After it, mixture is heated, homogenized, and pancreatin is introduced. The mixture is divided into two parts, one of which is subjected to fermentolysis. Both parts are dried, crushed, and mixed during introduction of preparation produced by means of successive extraction of biomass of Pythium coloratum micromycete with nonpolar extracting agent under above-critical condition, water, alkali, water, acid, water, alkali and water with the following combination of the first extract with hard residue, and reduced by water before using. EFFECT: increased quality of final product.
Patent RU-2206799-C1 (RU)
Title: Axial-blow blower
Inventor: BRUSILOVSKIJ I V
IPC: F04D29/38
Filed: 2001-11-29
Granted: 2003-06-20
Abstract: FIELD: blower manufacture, possibly making blowers with small percentage diameter of sleeve. SUBSTANCE: blower with low percentage diameter of sleeve (no more than 0.55) includes housing in which impeller is mounted and straightening out apparatus. Impeller includes sleeve to which working blades are secured. Blades have mean line of their profile in radial sections of impeller restricted by circle arc and camber lowering to periphery in inverse proportion to radius. Novelty is changing of angle of mounting of blade profile in each radial section of impeller according to cubic parabola law. Relation of chord of mean line of profile of impeller blade to peripheral radius changes along straight line on length of blade. EFFECT: enhanced efficiency of blower at high coefficient of static pressure. 4 dwg
Patent RU-2209069-C1 (RU)
Inventor: MAJER B O
IPC: A61K31/722
Filed: 2001-11-29
Granted: 2003-07-27
Abstract: FIELD: cosmetology, pharmacology. SUBSTANCE: the suggested innovation deals with manufacturing cosmetic, curative-cosmetic, pharmacological preparations and food additives. Chitosan- or chitosan suspension-based biologically active composition has nanogranules at their sizes not exceeding 100 nm; it contains components of plant and/or animal origin, and/or vitamins, and/or minerals, and/or artificial and synthetic preparations used in the field of cosmetology, curative cosmetology, pharmacopoeia and food industry. The content of gel or suspension in composition is not less than 10 weight%. The present innovation enables to increase penetrating capacity and activity of the composition suggested. EFFECT: higher efficiency. 13 cl
Patent RU-2202457-C1 (RU)
Title: Method for welding enameled tubes
Inventor: RIKKER V I
IPC: B23K101/34
Filed: 2001-12-27
Granted: 2003-04-20
Abstract: FIELD: welding, namely processes for welding tubes, for example enameled tubes, possibly at making, restoring gas- and oil mains pipelines, at transporting fluids containing oxygen, carbon dioxide or hydrogen sulfide, mineral salts at wide range of temperature and pressure values. SUBSTANCE: method comprises steps of using steel sleeves with inner corrosion resistant coating and with thickness of walls exceeding no more than by 1.3 times thickness of tube walls; welding sleeves to outer surface of steel tubes by angular seam at side of sleeve end opposite relative to end of tube butt and at shifting other end of sleeves relative to end of butt; applying enamel layer onto surfaces of openings of steel tubes; then dressing edges of tubes for welding in such a way that dressed edges are spaced from sleeves by distance equal to 0.5 - 1.0 of thickness value of tube wall at opening angle 25 - 40 degrees relative to vertical axis and with blunting corresponding to 0.5 -0.7 of thickness value of tube wall. Then cleaning is performed for further applying of additional enamel layer onto blunting surface and onto tube opening surfaces adjoining to butt. Assembling is realized without in butt gap. Welding for joining tubes is performed by two welded seams. First seam is made along thickness equal to summed thickness value of tube and sleeve. Further seams are made at cooling root seam until temperature at least twice less than enamel melting temperature. It provides simplification of method and its cost lowered at least by 5 times. EFFECT: enhanced quality of welded thin-wall tubes, integrity of enamel coating onto inner surface of thin-wall tubes, corrosion protection of root seams. 5 dwg, 1 ex
Patent RU-2211807-C1 (RU)
Inventor: KOBELJATSKIJ V G
IPC: C02F103/02
Filed: 2002-01-08
Granted: 2003-09-10
Abstract: FIELD: devices for water magnetization; applicable in heat power industry, agriculture, medicine, food industry. SUBSTANCE: device has pipeline, magnetizing coil, tubular core and cylindrical magnetic circuit provided with end covers. Core is made with shoulders on both ends. Covers are rigidly connected by tie-rod for joint motion in rotation. Core is installed so that shoulders together with surfaces of end covers form circular working clearances. Distance between poles, with any circular clearance, is preserved invariable. Device provides for establishing the value of treated layer of liquid. EFFECT: easily disassembled, serviceable at any orientation in space and direction of liquid supply. 4 dwg
Patent RU-2206774-C1 (RU)
Title: Method to control volume of combustion of internal combustion engine
Inventor: IBADULLAEV G A
IPC: F02B75/04
Filed: 2002-02-14
Granted: 2003-06-20
Abstract: FIELD: mechanical engineering; four-stroke internal combustion engines. SUBSTANCE: proposed method to control volume of combustion chamber is designed for internal combustion engine containing cylinder, piston, cylinder head with cylindrical cavity for undervalve cup with holes to let in air and let out exhaust gases, movable undervalve cup with intake and exhaust valves and camshaft with valve drive cam mechanism. Variable-volume combustion chamber is formed by undervalve cup together with intake and exhaust valves, walls of cavity of undervalve cup and piston crown. With engine operating at nominal power, maximum volume of combustion chamber is set owing to position of undervalve cup with valves in upper remote from piston point, thus providing minimum compression ratio. With engine operating at partial loads, volume of combustion chamber is decreased by shifting undervalve cup with valves towards piston. Decreased volume of combustion chamber is set basing on relationship between maximum volume of combustion chamber and decreased volume of combustion chamber directly proportional ratio of cylinder fill factor at nominal power to fill factor at partial loads and inreversely proportional to ratio of compression ratio at engine nominal power to compression ratio at engine partial loads. With engine operating at minimum load, volume of combustion chamber is decreased to minimum value by shifting under-valve cup to point close to piston. Minimum volume of combustion chamber and maximum compression ratio are set basing of relationship between maximum volume of combustion chamber and minimum volume of combustion chamber directly proportional to ratio of cylinder fill factor at nominal power to fill factor at minimum load and inreversely proportional compression ratio at engine nominal power to compression ratio at engine minimum load. EFFECT: increased efficiency of engine, reduced fuel consumption and improved engine performance. 1 dwg
Patent RU-2220824-C1 (RU)
Title: Method for making dead grooves in opening of part of hydraulic distributor
Inventor: BOGOSLAVTSEV VLADIMIR IVANOVIC
IPC: B23D3/02
Filed: 2002-05-27
Granted: 2004-01-10
Abstract: FIELD: machine engineering, hydraulic distributors for controlling transport vehicles, automobiles and buses. SUBSTANCE: method comprises steps of cutting dead grooves by means of gear shaper; in order to lower mass and size of hydraulic distributor due to making grooves with less length and sufficient depth, before cutting grooves making recesses on portions of part opening designed for further cutting-in of gear shaper; during cutting groove moving gear shaper after cutting-in at each working stroke in parallel relative to axis of opening. It is possible to make recesses in pairs due to drilling in part through and dead radial openings coaxial one with another. EFFECT: lowered mass and dimensions of hydraulic distributor. 5 cl, 6 dwg
Patent RU-2202711-C1 (RU)
Inventor: ZAKHAROV B S
IPC: F04B47/00
Filed: 2002-05-31
Granted: 2003-04-20
Abstract: FIELD: oil producing industry. SUBSTANCE: proposed valve contains housing with fitted-in seat. Plate with rod passing through guide engages with seat. Guide is made in housing partition with peripheral holes to pass liquid. Compression spring presses plate to seat. Movable weight is installed between partition and spring. Movable weight is made in form of turned over cup. Spring is arranged in cup inner space. EFFECT: improved reliability in operation. 2 cl, 4 dwg
Patent RU-2223004-C1 (RU)
Inventor: KVASENKOV O I
IPC: C12P1/02
Filed: 2002-08-09
Granted: 2004-02-10
Abstract: FIELD: nonalcoholic industry. SUBSTANCE: method involves blending citrus juice with sugar syrup, concentrate of fruit pomace acid hydrolysate and preparation produced by sequential extracting of Mortierella beljakovae micromycet biomass with the use of non- polar extractant in above-critical state, water, alkaline, water, acid, water, alkaline and water, with following joining of first extract with solid residue. EFFECT: improved protective and prophylactic properties of beverage and increased breaking resistance.
Patent RU-2227405-C1 (RU)
Title: Method for preparing of grain before laying for storage
Inventor: KVASENKOV O I
IPC: C12P1/02
Filed: 2002-09-16
Granted: 2004-04-27
Abstract: FIELD: postharvest treatment of grain before laying for storage. SUBSTANCE: method involves treating grain flow in superhigh frequency field with propionic acid including additive of preparation obtained from Mortierella jenkinii micromycet biomass produced by predetermined process. EFFECT: reliable storage of grain. 2 ex
Patent RU-2227485-C1 (RU)
Title: Method for producing dried supplies out of plant raw material
Inventor: KVASENKOV O I
IPC: A23B7/154
Filed: 2002-10-28
Granted: 2004-04-27
Abstract: FIELD: agriculture, food industry. SUBSTANCE: the present innovation deals with technology for producing dried supplies out of plant raw material indicated for further usage either as a whole or in pieces in composition of sterilized preserves. One should treat plant raw material with immunostimulant being the preparation obtained due to successive extracting Mortierella lignicola micromycete biomass with nonpolar extragent in supracritical state with water, alkali, water, acid, water, alkali and water followed by combining the first extract with solid residue at the quantity of about 0.01% against the weight. Then it should be kept for about 2-5 h to remove the moisture. EFFECT: higher quality of supplies. 3 ex