baber/WOPTO huggingface dataset:
Patent DE-69434119-D1 (DE)
Inventor: SCHUTT ERNEST G
IPC: B01J13/02
Filed: 1994-08-01
Granted: 2004-12-09
Abstract: A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760 - x) mm Hg at 37  DEG C, where x is the vapor pressure of the second gas at 37  DEG  C, and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37  DEG C; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75 % of the first average diameter and are stabilized at the second average diameter; methods and kits for preparing microbubbles; and methods for using such microbubbles as contrast agents. <IMAGE>
Patent DE-69502068-D1 (DE)
Inventor: KIM HYONG-EUI
IPC: F03C1/06
Filed: 1995-03-24
Granted: 1998-05-20
Abstract: A variable displacement mechanism for a swash plate type hydraulic pump or motor are disclosed, in which a swash plate, a swash plate guiding wall, a tilting control piston, and a swash plate tilting guiding and swash plate rotation preventing pin are included for varying the requiring flow rate (volumetric displacement) per revolution without the rotation and departure of the swash plate even during the tilting of the swash plate angle and during the rotation of the hydraulic pump or motor. The sides of the swash plate is spherical for smoothing the tilting of the swash plate, and a securing pin accommodating slot is formed on the lower portion of the swash plate. Further, there are provided a securing pin for preventing an interlocked rotation of the swash plate, and a slot formed on the bottom of a front cover for installing the securing pin. A housing or the front cover is provided with a guide wall for guiding the tilting of the swash plate, so that the volumetric displacement can be varied even during the rotation of the hydraulic pump or motor, thereby varying the discharge rate of the hydraulic pump or varying the rotating speed of the hydraulic motor in a safe manner. <IMAGE>
Patent DE-69516169-D1 (DE)
Inventor: RIVIER E
IPC: G01N33/48
Filed: 1995-12-15
Granted: 2000-05-11
Abstract: Compounds are provided termed "betides" which mimic peptides and which contain one or more residues of aminoglycine, C alpha -aminoalanine, aminosarcosine or the like wherein the side chain amino group has been acylated and optionally also alkylated. Generally, betides have the formula: XN-X1-X2-X3-Xm-X4-X5-X6-XC, where XN is an acyl or other N-terminal group or a peptide up to about 50 amino acids in length having such a group; XC is OH, NH2 or other C-terminal group or a peptide up to about 50 amino acids in length having such a group; and X1-X6 are each independently a betide amino acid or  alpha -amino acid or des-X; and Xm is a peptide up to about 50 amino acids or des-X; provided however that at least one of X1-X6 is a betide amino acid residue having the formula:   <IMAGE>   wherein Ro is H or CH3, R and R2 are H or lower alkyl, and R3 is an acyl group, an isocyanate group, an isothiocyanate group or a sulfonyl group. In methods for making betides, an aminoglycine residue can be subjected to side chain acylation, and optionally also alkylation, after it has been incorporated into a peptide intermediate. This method can be used as a valuable tool to synthesize and screen multiple substituents at one or more positions in a peptide, permitting simultaneous screening of betides which mimic peptides having a large number of natural or unnatural amino acid substituents at a particular position, and optionally both D- and L-isomers of those substituents.
Patent DE-69532576-D1 (DE)
Inventor: USHIO HIDEKI
IPC: C07D405/04
Filed: 1995-06-23
Granted: 2004-03-25
Abstract: There is disclosed a process for producing a 2-(tetrazol-5-yl)-4-oxo-4H-benzopyran of general formula (1): <CHEM> which comprises reacting a hydroxyacetophenone of general formula (2): <CHEM>  with a tetrazole compound of general formula (3): <CHEM> in the presence of a base in a solvent composed mainly of at least one selected from hydrocarbons, halogenated hydrocarbons and alcohols, and then treating the reaction mixture under acidic conditions.
Patent DE-69536024-D1 (DE)
Inventor: DELPRAT MARC
IPC: H04W12/10
Filed: 1995-04-07
Granted: 2010-01-07
Abstract: The method involves use of two different coding modes. Each mode corresponds to a predetermined coding source and coding channel for transmission of a signal in each transmission direction. Each coding source corresponds to a data flow and each coding channel corresponds to a coded data output of total data flow for coded source data. Analysis is made of the transmission quality between the mobile unit and the base station in each direction. For each direction, one of the coding modes is selected as a function of the analysis of the transmission quality.
Patent DE-69616268-D1 (DE)
Inventor: WIDMAN MICHAEL F
IPC: B29D11/00
Filed: 1996-12-27
Granted: 2001-11-29
Abstract: A rotational indexing base curve deposition array for assembling contact lens base curves and front curves with a prescribed and programmable angular orientation to produce a contact lens having a selected axis placement therein, such as a toric axis for a toric contact lens. An array of front curve molds are arranged in a support pallet with a dosed amount of monomer mixture deposited into each of the front curve molds. An array of deposition tubes, positioned in a support plate and coupled to a vacuum source, is used to pick up and support an array of base curve molds. Each of the deposition tubes is then angularly rotated in to the support plate to a selected angularly indexed position therein. A common angular rotational drive is coupled to each of the deposition tubes in the array to angular index each of the deposition tubes to a precise angular position in the support plate. The common angular rotational drive is driven by a stepper motor which can be controlled in a programmable manner to change the selected angularly indexed position. The stepper motor drives moveable racks, which drive pinion gears around the deposition gears. The angularly indexed array of base curve molds is then assembled over the array of front curve molds to produce toric lenses having first and second optical surfaces which are precisely angularly indexed relative to each other.
Patent DE-69620756-D1 (DE)
Inventor: MACLAUGHLAN E
IPC: C07D249/08
Filed: 1996-06-05
Granted: 2002-05-23
Abstract: A combination therapy comprising a therapeutically-effective amount of an epoxy-free spirolactone-type aldosterone receptor antagonist and a therapeutically-effective amount of an angiotensin II receptor antagonist is described for treatment of circulatory disorders, including cardiovascular disorders such as hypertension, congestive heart failure, cirrhosis and ascites. Preferred angiotensin II receptor antagonists are those compounds having high potency and bioavailability and which are characterized in having an imidazole or triazole moiety attached to a biphenylmethyl or pyridinyl/phenylmethyl moiety. A preferred epoxy-free spirolactone-type aldosterone receptor antagonist is spironolactone. A preferred combination therapy includes the angiotensin II receptor antagonist 5-[2-[5-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-pyridinyl]phenyl-1H-tetrazole and the aldosterone receptor antagonist spironolactone.
Patent DE-69622728-D1 (DE)
Inventor: KOOLEN JOSEPHUS
IPC: A61K39/395
Filed: 1996-09-12
Granted: 2002-09-05
Abstract: The present invention relates to a glycoconjugate immunoreactive with Toxoplasma gondii antibodies, (monoclonal) antibodies against these glycoconjugates, and cell lines capable of producing monoclonal antibodies. The invention is further concerned with immunochemical reagents and methods for the detection of T. gondii or antibodies directed agains T. gondii. Furthermore the invention relates to a therapeutic reagent for the inhibition of replication of T. gondii parasites and a method for the production of a live attenuated T. gondii vaccine. It has now been found, and in contrast with earlier publications in this art, that several glycoconjugates are immunoreactive with Toxoplasma gondii specific antibodies comprising a glycan core structure having general formula (I) wherein R1=Hydrogen, -PO 3 -CH 2 -CH 2 -NH 2 (ethanolamine-phosphate), or -PO 3 -CH 2 -CH 2 -NH-X, wherein X=a T. gondii specific antigen; wherein R2=±-O-R4, ±(1-4)-O-anhydromannitol or ±(1-4)-O-glucoseamine optionally ±(1-6)-linked to the inositol moiety of a phosphatidylinositol membrane anchor; wherein R3=a monosaccharide moiety, wherein R4=Hydrogen or -L-R5, wherein L=a bivalent organic radical and R5=a functional group that allows coupling to a carrier. A preferred embodiment of the monosaccharide moiety is a hexose moiety, more preferred is a glucose moiety, and most preferred is a glucose moiety which is bonded to the GalNAc-moiety by an ±1,4 glycosidic bond. It has been found that the glycoconjugates according to the present invention are particularly suitable for diagnosing T. gondii infected humans.
Patent DE-69629554-D1 (DE)
Inventor: IGARASHI YOSHIO
IPC: C07C35/23
Filed: 1996-03-13
Granted: 2003-09-25
Abstract: A cheap industrial method for making 1,2-dibromoindane represented by Formula (I), where the configuration of the bromine atoms on position 1 and position 2 can be trans or cis, or it can be a mixture of trans and cis isomers by reacting indene with hydrogen bromide in the presence of hydrogen peroxide. Water may be used as the solvent and another aprotic organic solvent may be present.
Patent DE-69630821-D1 (DE)
Inventor: HERSLOEF BENGT
IPC: A23L29/10
Filed: 1996-09-13
Granted: 2003-12-24
Abstract: A new method for producing a fractionated vegetable oil from a plant material. The plant material is extracted with a non-polar solvent and the solvent is evaporated giving a crude oil which includes non-polar and polar lipids. The crude oil is mixed with an alcohol at a controlled temperature and a resulting alcoholic phase is separated and evaporated to recover a polar lipid rich fractionated vegetable oil. The invention also refers to the use of the polar lipid rich fractionated vegetable oil as a surface active agent.
Patent DE-69636895-D1 (DE)
Inventor: CANARD BRUNO
IPC: C12Q1/6869
Filed: 1996-05-29
Granted: 2007-03-29
Abstract: The invention is directed to the use of RNA or DNA polymerases having 3'-intrinsic editing activity (3'-IEA) in the presence or absence of a deactivating agent to remove a protecting group from the 3'-position of oligo- or polyribo- or deoxyribonnucleotides. The use is concerned with the incorporation of dNTPs into DNA templates in order to determine the concentration and / or sequence of said templates. In particular the use is concerned with an improved non gel-based sequencing method.
Patent DE-69700082-D1 (DE)
Inventor: DE LA POTERIE VALERIE
IPC: C08K5/00
Filed: 1997-01-27
Granted: 1999-02-11
Abstract: Use in a cosmetic composition to be applied to the skin or mucous or semi-mucous parts, of a polymeric system consisting of an aqueous dispersion of particles of a film-forming polymer which gives a film having a hardness of less than about 110.
Patent DE-69704137-D1 (DE)
Inventor: MARGARIA THOMAS
IPC: C21C1/00
Filed: 1997-06-23
Granted: 2001-04-05
Abstract: An alloy which is added to the melt when making spheroidal graphite cast iron comprises (wt.%) 0.005-3% rare earths, 0.005-3% bismuth, lead and/or antimony, 0.3-3%, preferably 0.5-2%, calcium, 0.3-3%, preferably 0.5-1.5%, magnesium and the balance silicon and iron in a ratio of Si to Fe of >2, preferably >2.5. The alloy may be added to the melt in the form of wire wool.
Patent DE-69706318-D1 (DE)
Inventor: GUSKEY JOHN
IPC: A61K8/36
Filed: 1997-12-18
Granted: 2001-09-27
Abstract: Disclosed are cosmetic gel-solid stick compositions comprising particulate antiperspirant active, a fatty acid gellant having a select dimer-to-monomer ratio and an optional secondary gellant, and an anhydrous liquid carrier. The select dimer-to-monomer ratio of the fatty acid gellant helps provide the composition with improved hardness, low residue performance and efficacy, especially when used in combination with a secondary gellant.
Patent DE-69722325-D1 (DE)
Inventor: BERHAUT JEAN-BERNARD
IPC: D21H17/36
Filed: 1997-07-24
Granted: 2003-07-03
Abstract: Fireproof paper with increased resistance, notably conforming to classification M1, comprises at least cellulose fibres and at least incombustible fillers with flame retardant properties, dry ratio, R, of charges to fibres = 1-9, and 1-15 pts.wt. halogenated polymer(s) in form of stable aqueous dispersion to form the base mixture; and 0.1-10 wt.% fireproof salt(s) soluble or dispersible in aqueous medium; dry weight measured relative to paper at 100 degrees C.
Patent DE-69731398-D1 (DE)
Inventor: CATHEY A
IPC: H01J29/08
Filed: 1997-12-31
Granted: 2004-12-02
Abstract: An anode of a flat panel display has a glass substrate, a patterned black grille on the substrate, a conductive layer covering the grille and the substrate, a phosphor layer covering, and one or more additional transparent layers that reduce the reflectance of the flat panel display from 14% down to 1%-4%. These additional layers are placed between the black matrix grille and the substrate, and between the conductive layer and phosphor layer. The two additional layers are selected and designed to reduce the reflectance that occurs at these respective interfaces.
Patent DE-69731483-D1 (DE)
Inventor: CHENG YUNG-CHI
IPC: A61P37/00
Filed: 1997-11-14
Granted: 2004-12-09
Abstract: The present invention relates to the discovery that certain beta-L-dioxolane nucleoside analogs which contain a uracil base, and preferably, a 5-halosubstituted uracil base, exhibit unexpectedly high activity against Epstein-Barr virus (EBV), Varciella-Zoster virus (VZV) and Herpes Virus 8 (HV-8). In particular, the compounds according to the present invention show potent inhibition of the replication of the virus (viral growth) in combination with very low toxicity to the host cells (i.e., animal or human tissue). Compounds are useful for treating EBV, VZV and HV-8 infections in humans.
Patent DE-69731527-D1 (DE)
Inventor: ROBINSON NEIL
IPC: H04B7/185
Filed: 1997-05-20
Granted: 2004-12-16
Abstract: A method enables a subscriber unit (20) to access a common communication system to communicate with a selected communication system. The subscriber unit receives (404) an indication of any communication systems available in a geographic region associated with the common communication system and requests access to the selected communication system. After receiving (506) an enabling program for the selected communication system, the subscriber unit transfers (508) the enabling program to an external processing device. A novel subscriber unit (20) and external processing device (24) are also described.
Patent DE-69806546-D1 (DE)
Inventor: HOLDSWORTH MELVYN
IPC: B60Q1/26
Filed: 1998-05-05
Granted: 2002-08-22
Abstract: A warning lamp for producing a flashing light has a reflector 30 mounted on a rotary platform 20 which is journalled on a stationary vertical shaft 18. A light bulb 28 is arranged to produce a horizontal light beam from the reflector. A pulley 38 on the shaft 36 of an electric motor 34 is coupled to the platform by a flexible belt 26. A removable tyre 44, which is fitted to the pulley 38, can be removed so as to reduce the effective diameter of the pulley 38, thereby causing the reflector to rotate at a second rate, slower than the rotation rate when the tyre is present.
Patent DE-69811527-D1 (DE)
Inventor: NIJHOF JAN
IPC: F16L21/04
Filed: 1998-11-06
Granted: 2003-03-27
Abstract: The invention relates to a sealing ring (5) which is formed by a continuous body, of which the outer surface is formed by an elastic material and which is easily deformable in peripheral direction but practically not so in cross-sectional direction, wherein one or more weakenings (11) are formed in the elastic material. These weakenings, which can take the form of recesses, run at an angle to the peripheral direction and preferably transversely thereof. The weakenings or recesses can be arranged spaced apart in the body in cross-sectional direction, for instance alternatingly in the top and the bottom side. The invention further relates to a pipe coupling provided with a housing having on both sides an opening for receiving a pipe, a sealing ring as described above for arranging round the pipe and means connected to the housing for pressing the sealing ring.
Patent DE-69813106-D1 (DE)
Inventor: NERI CELSO
IPC: F16B12/00
Filed: 1998-06-03
Granted: 2003-05-15
Abstract: A device for connecting flat elements (1a, 1b) to each other, namely for the construction of pieces of furniture, comprising hooking means (2) and locking means (3), fixable along a common connection axis (X) to a respective flat element (1a, 1b) and engageable to each other to connect them. The hooking means (2) are fixable inside a groove (4) formed in the respective flat element (1b) coaxially to the connection axis (X) and comprise protruding members (7) which extend orthogonally to said axis. The locking means (3) comprise seats (13) for housing the protruding members (7) and define a track (10) in which a tie rod (14) is placed, which is slidable in a parallel way with respect to the connection axis (X) for engaging with the protruding members (7), operating means (18, 19, 20) for controlling the sliding of the tie rod (14) being provided. <IMAGE>
Patent DE-69814690-D1 (DE)
Inventor: NAKAZATO ATSURO
IPC: C07D495/04
Filed: 1998-12-03
Granted: 2003-06-18
Abstract: A nitrogen-containing tetracyclic compound represented by the formula: <CHEM> wherein Y<1>-Y<2>-Y<3> is N-C=N or a group represented by the formula: C=C-NR<3> (wherein R<3> is a hydrogen atom, a C1-5 alkyl group or a nitrogen-containing C2-10 alkyl group), Y<4> is S, SO, SO2, CH2 or a group represented by the formula: NR<4> (wherein R<4> is a C1-5 alkanoyl group or a C1-5 alkyl group), R<1> and R<2> are the same or different, and are each a hydrogen atom, a C1-10 alkyl group, a C3-15 alkoxyalkyl group or a C3-15 alkylaminoalkyl group, or R<1> and R<2> taken together with the nitrogen atom to which they are attached form a cyclic amino group, X<1> and X<2> are the same or different, and are each a hydrogen atom, a C1-5 alkyl group, a C1-5 alkoxy group or a halogen atom, and n is 0, 1 or 2; or a pharmaceutically acceptable salt thereof.
Patent DE-69815683-D1 (DE)
Inventor: HELLAND PER
IPC: A61B17/66
Filed: 1998-07-07
Granted: 2003-07-24
Abstract: The invention relates to a distraction apparatus for holding a fracture during the healing process. The apparatus includes screws or pins for insertion into a bone at points proximal and distal relative to a fracture site, and a pair of springs which can be connected externally between the screws or pins at spaced positions thereon. The springs act as an extension spring and a compression spring respectively between the screws or pins. The invention is characterized in that the springs are connected at the spaced positions at such distances relative to the bone that the springs will exert moments of force in order to obtain a desired torque load at the fracture site.
Patent DE-69835244-D1 (DE)
Inventor: MICHELSON GARY KARLIN
IPC: A61B17/16
Filed: 1998-02-11
Granted: 2006-08-24
Abstract: Anatomically contoured anterior cervical plates with bone ingrowth surfaces, providing for intersegmental compressive preloading, and a rigid and locked interface to all of the bone screws, with those engaging the vertebrae deployed in highly convergent pairs. The bone screws have a tapered self-tapping leading end, an increasing root diameter with a generally constant outer diameter with a thread that is narrow and sharp throughout and an enlarged head portion capable of an interference fit to the receiving holes of the plate. Instrumentation consists of plate holders, a compression apparatus and a pilot hole forming device that interlocks with the plate. Methods for spinal compression and bone hole preparation are provided.
Patent DE-69836420-D1 (DE)
Inventor: STARKEY GLENN
IPC: B29C45/33
Filed: 1998-03-10
Granted: 2006-12-28
Abstract: A side-action mechanism is provided for forming recesses or apertures in injection molded plastic parts and which includes a slide carrier and a driver actuator therefor which are part of a modular side-action cam unit that can be attached entirely into one mold half, e.g., the core half, so as to avoid having to machine and customize the other mold half or cavity half as with prior side-action devices. In addition, the modular side-action cam unit provides a driving surface that is preferably flat which engages the bottom flat of the cavity half to obviate the alignment problems which can occur in the prior angled cam pin side-action mechanisms. The present modular cam unit is a small unit and does not take as long to install into the mold as the prior side-action cam mechanisms which required installing parts in both the cavity and core halves of the mold. The cam unit herein in its preferred form, utilizes a total of five (5) parts which are all self-contained in a housing to provide a design which can be fit in the mold in a very straightforward and quick manner by the mold builder. The actuator is spring biased so that the opening force of the mold is not used to withdraw the core pin from the mold cavity. Preferably, two-stage spring loading is utilized with a high initial spring load applied to free the coring pin from the plastic in the cavity and a lower secondary load applied for the remainder of the withdrawal travel.
Patent DE-69836632-D1 (DE)
Inventor: VAN DONGEN JOHANNUS
IPC: C12Q1/6886
Filed: 1998-05-13
Granted: 2007-01-25
Abstract: The invention relates to the field of cytogenetics and the application of genetic diagnostic techniques in pathology and haematology. Specifically, the invention relates to nucleic acid probes that can be used in hybridisation techniques for the detection of chromosomal aberrations and other gene rearrangements such as immunoglobulin (Ig) and T cell receptor (TCR) gene rearrangements. The probes provided by the invention are a distinct and balanced pair of probes of comparable size each preferably being from 1 to 100 kb, or smaller, and flanking a potential breakpoint in a chromosome.
Patent DE-69839170-D1 (DE)
Inventor: AWAD ELIAS A
IPC: F17C7/00
Filed: 1998-07-28
Granted: 2008-04-10
Abstract: A noise reducing diffuser which reduces the sound energy created by a pressurized gas while it is being expelled through a nozzle. The diffuser consists of an elongated enclosure with openings at each end that is attached to the output of the gas nozzle. The dimensions of the enclosure, particularly its distance from the sound source, effective diameter and length, are chosen to specifically eliminate audible noise created by the escaping gas by conversion of a portion of the longitudinal component of the sound energy to an increased radial component that can then be dissipated by repeated contact with the wall of the elongated enclosure. <IMAGE>
Patent DE-69900861-D1 (DE)
Inventor: ALROY YORAM
IPC: A61B5/00
Filed: 1999-02-22
Granted: 2002-03-21
Abstract: An emergency signaling or diagnostic device (10), particularly with an ECG signaling device (11, 11') embedded within a wallet (35) for signaling a health condition of an owner of the device. The wallet (35) may have embedded therein functions (40) of a cellular telephone and may include a vocalizing unit (16) for producing an acoustic signal representative of the owner's ECG.