Patent SG-11201909504V-A (SG)
Title: Rubidium elution system
Inventor: LEFORT ÉTIENNE
IPC: G01T1/164
Filed: 2018-04-13
Abstract: 28 Controller 1 18 30 22 FIG. 3 44 10 Patient Outlet 16 1 -I I- 33 e+ detect 20 User Interface 26 14 _r4 24 40 82 Sr/Rb Gen Waste Res. Saline Supply (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 18 October 2018 (18.10.2018) WIPO I PCT I iiimmonitsonolomolmommomilmovois (10) International Publication Number WO 2018/187876 Al 1-1 N co N co 00 O C (51) International Patent Classification: A61M 36/06 (2006.01) GO1T 1/164 (2006.01) A61B 5/00 (2006.01) (21) International Application Number: PCT/CA2018/050452 (22) International Filing Date: 13 April 2018 (13.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/485,420 14 April 2017 (14.04.2017) US (71) Applicants: JUBILANT DRAXIMAGE INC. [CA/CA]; 16751 Trans-Canada Highway, Kirkland, Quebec H9H 4J4 (CA). OTTAWA HEART INSTITUTE RESEARCH CORPORATION [CA/CA]; 40 Ruskin Street, Ottawa, Ontario K1Y 4W7 (CA). (72) Inventors: LEFORT, Etienne; 14 Dufferin, Kirkland, Quebec H9J 3X6 (CA). TEOLI, Vincenzo; 10275 Tan- guay, Montreal, Quebec H3L 3G6 (CA). DEKEMP, Robert A.; 92 Ross Avenue, Ottawa, Ontario K1Y ON5 (CA). KLEIN, Ran; 247 Pleasant Park Road, Ottawa, On- tario K1H 5M4 (CA). (74) Agent: McCARTHY TETRAULT LLP; Box 48, Suite 5300, Toronto Dominion Bank Tower, Toronto, Ontario M5K 1E6 (CA). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, = (54) Title: RUBIDIUM ELUTION SYSTEM (57) : Provided are 82 Sr/ 82 Rb elution systems that accept patient weight as a input function in order to determine an optimal quantity of radioactive rubidium-82 for delivery to a patient pursuant to an imaging scan. Also disclosed are systems that deliver a saline flush to remove residual Rb from the system downstream of the generator, and preferably deliver the removed residual 82 82 Rb to the patient. Other disclosed systems measure the total volume of saline that flows through a 82 Sr/ 82 Rb generator, a total volume of saline that flows through the generator and through a bypass line, or a total volume of saline received by a waste reservoir, in order to monitor system components so that optimal system functioning is assured. [Continued on next page] WO 2018/187876 Al MIDEDIMOMOIDEIREEMOMOHOMMOIROMEEN SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE