baber/WOPTO huggingface dataset:
Patent DE-69627595-T2 (DE)
Inventor: HIRATA MASAYOSHI
IPC: G11C16/06
Filed: 1996-09-18
Granted: 2004-03-25
Abstract: In a flash memory, each of substitution information circuits associated to a redundant memory cell array has an erase circuit for erasing the substitution information stored in memory cells in the substitution information circuit when the defectiveness of the corresponding memory cell in a main memory cell array is dissolved. <IMAGE>
Patent DE-69712608-T2 (DE)
Inventor: KARIMIAN KHASHAYAR
IPC: A61K31/495
Filed: 1997-02-26
Granted: 2002-08-29
Abstract: Novel thiadiazole compounds are provided, which are effective as proton pumps inhibitors, useful in treating peptic ulcers by inhibition of the proton pump enzyme H+/K+-ATPase. The compounds are 3-substituted 1,2,4-thiadiazolo [4,5- alpha ]benzimidazole and 3-substituted imidazo[1,2-d]-1,2,4-thiadiazoles corresponding to the general formula:   <IMAGE>   where X and Z either represent an optionally substituted benzene ring fused to the diazole nucleus, or represent a variety of independent chemical groupings (hydrogen, lower alkyl, halo, etc.) and Y is an electronegative group.
Patent DE-69716015-T2 (DE)
Inventor: SHANBROM EDWARD
IPC: A01N59/12
Filed: 1997-06-20
Granted: 2003-07-10
Abstract: A process for disinfecting protein solutions operates by flowing the solutions through a bed of iodinated organic polymer that acts as a gel filtration material. The preferred types of gel filtration material is Sephadex brand cross-linked dextrans, either G-25 or A-25 (DEAE modified Sephadex). The various types of cross-linked dextrans are readily iodinated before use by being mixed dry with elemental iodine at an elevated temperature such as 37 DEG  C. Sephadex brand cross-linked dextrans can be readily iodinated to 50% weight of iodine to weight of dextrans or more. The preferred level of iodination is 30-40%. Before use the used it is first swelled in aqueous medium and then poured into a chromatographic column. Six ml of swelled 30% iodine Sephadex A-25 can effectively destroy virus in at least one liter of 5% human IgG.
Patent DE-69730450-T2 (DE)
Inventor: WATTS RICHARD
IPC: G01N35/00
Filed: 1997-06-30
Granted: 2005-09-08
Abstract: An automatic chemistry analyzer is provided having a high throughput and a high reliability. The analyzer uses nephelometric and turbimetric analyzers to analyze a wide variety of parameters within liquid samples typically generated in, for example, a large medical testing laboratory. The machine employs a unique probe and stirring rod assembly mounted at a slight angle with one another using rack and pinion assemblies so that the lower end of the probe and the lower end of the stirring rod are in very close proximity to one another. This feature allows the machine to be used in unusually small reaction cuvettes. The analysis machine also includes an onboard control sample so that the machine can be programmed to periodically calibrate its analyzing equipment during the course of normal operation. The machine also includes a sample station carousel having retainer clips for retaining a sample container rack which is constructed to retain a bar-coded card containing information regarding reagents used in the machine. A bar code reader located proximate to the sample carousel reads the bar-coded reagent information into the controller.
Patent DE-69734713-T2 (DE)
Inventor: BYRA R
IPC: A61K31/19
Filed: 1997-05-14
Granted: 2006-07-06
Abstract: A second generation of antineoplaston therapies with markedly improved antineoplastic activity is disclosed. Among others, members of the antineoplaston family include phenylacetate (PN), 3-phenylacetyl-amino-2, 6, piperidinedione (CN), and hydrolysis derivatives of CN: phenylacetylglutamine (PG) and isophenylacetylglutamine (Iso-PG). In part, these increases in antineoplastic activity result from large increases in the transport of antineoplaston compositions into cells. Importantly and unexpectedly these increases in antineoplastic activity also result from the capacity of the drug delivery system to direct antineoplaston compounds intracellular trafficking to intracellular binding sites influencing cell viability and proliferation. Liposomal formulations of antineoplaston compositions increase in vitro antineoplastic activity by a factor of 750 to 1500 as compared to administration of antineoplaston compounds given without liposomal formulations. In addition, these liposomal formulations enhanced cellular uptake of antineoplaston compounds from 30 to more that 80 fold. Liposomal formulations were also found to increase intracellular levels of the antineoplaston CN (3-phenylacetyl-amino-2,6, piperidinedione) by directing CN to intracellular binding sites that influence cell viability and proliferation and block its hydrolysis. Under conditions where free CN has no antineoplastic activity, liposomally formulated CN can produce essentially complete and relatively long-lasting blockade of cell growth. Cell growth was found to be restored as intracellular levels of bound CN decrease to undetectable levels.
Patent DE-69734983-T2 (DE)
Inventor: BRUGNARA CARLO
IPC: C07D213/06
Filed: 1997-03-19
Granted: 2006-09-07
Abstract: The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation. The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups is replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P. the compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.
Patent DE-69736780-T2 (DE)
Inventor: WEI ZIPING
IPC: C07K14/505
Filed: 1997-08-01
Granted: 2007-09-06
Abstract: This invention provides compositions consisting essentially of a polypeptide and a water-soluble polymer covalently bound thereto at the N-terminal ±-carbon atom via a hydrazone or reduced hydrazone bond, or an oxime or reduced oxime bond. This invention also provides methods of making the instant compositions, pharmaceutical compositions comprising same, and kits for use in preparing same.
Patent DE-69805821-T2 (DE)
Inventor: DEN OS ANNA
IPC: G10L17/00
Filed: 1998-09-15
Granted: 2003-01-16
Abstract: A method of and an arrangement for obtaining reference information comprising speech parameter data and variability data from test or enrollment speech (2) of an individual. Classes of speakers are defined, each class comprising speech parameter data and variability data of said speech parameter data, obtained from speech of a plurality of speakers. Speech parameter data (3) of the test or enrollment speech (2) are obtained and variability data are allocated to the speech parameter data in accordance with variability data of the class of speakers assigned to the individual. The speech parameter data (3) and allocated variability data comprise the above reference information (5). With the reference information (5) thus obtained an improved method and arrangement for speaker verification is provided. <IMAGE>
Patent DE-69809905-T2 (DE)
Inventor: LEEMHUIS ANTONIUS
IPC: A61P43/00
Filed: 1998-05-11
Granted: 2003-08-28
Abstract: The invention relates to 20-aralkyl-5alpha-pregnane derivative having general formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 is (H,OR), (H,OSO3H) or NOR; R is H, (C1-6)alkyl or (C1-6)acyl; each of R2 and R3 is independently hydrogen or (C1-6)alkyl; X is a straight chain divalent C1-8 hydrocarbon radical, optionally comprising a double or a triple bond; or X is -(CH2)m-CR7R8-; m=0-4; at least one of R7 and R8 is (C1-4)alkyl, hydroxy, (C1-4)alkoxy or halogen; the other, if present, being hydrogen; or R7 and R8 together represent O or NOR'; R' is H, (C1-6)alkyl or (C1-6)acyl; each of R4, R5 and R6 is independently hydrogen, hydroxy, (C1-4)alkoxy, halogen, NR9, R10 or (C1-4)alkyl, optionally substituted by hydroxy, alkoxy, halogen or oxo; each of R9 and R10 is independently hydrogen or (C1-4)alkyl; and the dotted lines indicate a DELTA7 or a DELTA8 double bond, or a pair of conjugated double bonds selected from DELTA7,14, DELTA8,14 and DELTA6,8(14). The compounds of the invention have meiosis activating activity and can be used for the control of fertility.
Patent DE-69811949-T2 (DE)
Inventor: OREMUS VLADIMIR
IPC: A61K31/4402
Filed: 1998-12-16
Granted: 2004-03-04
Abstract: The invention relates to 1,3-disubstituted ureas of general formula (I) where R1 is an aryl, R2 is nitro and/or amino, and X is oxygen and/or sulfur, and the method of preparing thereof which consists in treating aromatic amines with isocyanates. Isocyanates may be formed in situ and the reaction carried out in toluene, at 80° C. If the nitro group is formed, it is reduced with hydrogen in the presence of palladium catalyst to the amino group. The obtained 1,3-disubstituted ureas are inhibitors of the activity of the acyl co-enzyme A: cholesterol acyltransferase (ACAT) enzyme, and may be used to inhibit cholesterol esterification and absorption in hypercholesterolemia.
Patent DE-69812402-T2 (DE)
Inventor: FERRARO DANIELA MONICA CATERIN
IPC: B65D21/02
Filed: 1998-11-25
Granted: 2004-02-05
Abstract: A food container is superimposed onto the upper end of a beverage receptacle. The container has a side wall and bottom wall in which there is formed at least one channel to allow the passage out through the container of a drinking straw which penetrates into the receptacle. The bottom wall is provided with a plurality of connectors for allowing connection of the food container to receptacles of different sizes at their upper end.
Patent DE-69815549-T2 (DE)
Inventor: RYAN EUGENE
IPC: A01N25/30
Filed: 1998-10-09
Granted: 2003-12-24
Abstract: There is disclosed a pesticidal composition comprising by volume, approximately 40 to 60% eucalyptus oil, 10 to 30% cajaput oil, 10 to 30% lemongrass oils and 4 to 20% of surfactant. The composition is used in a method for controlling pesticidal activity at a locus which comprises applying an effective amount of the composition thereto.
Patent DE-69821246-T2 (DE)
Inventor: KRANE STEPHEN M
IPC: C12N5/10
Filed: 1998-07-31
Granted: 2004-11-04
Abstract: The invention includes a method of determining the level of Type I collagen fragments in a biological fluid using an antibody which is immunospecific for an epitope contained in one of the following sequences: (1) Ala-Hyp-Gly-Asp-Arg-Gly-Glu-Hyp-Gly-Pro-Hyp-Gly-Pro-Ala, or (2) Gly-Asn-Ser-Gly-Glu-Hyp-Gly-Ala-Hyp. under conditions effective to allow determination of the level of collagen fragments in the sample which contain the epitope. The method is useful for assessing the level of bone collagen degradation, particularly in humans. Also disclosed are antibodies and kits which can be used in the method.
Patent DE-69838811-T2 (DE)
Inventor: BLANKENBERG FRANCIS G
IPC: G01N33/60
Filed: 1998-04-28
Granted: 2008-10-30
Abstract: A method of imaging apoptosis in vivo, using radiolabeled annexin, is described.
Patent DE-69901474-T2 (DE)
Inventor: SOLSVIK RONNY
IPC: C04B18/04
Filed: 1999-03-12
Granted: 2002-10-31
Abstract: A method of treating a shell sand by heating it to 300° C. maximum for a time sufficient to remove substantially all of the water and organic content while maintaining substantially all of the inherent porosity of the shell sand. Generally, the time required varies between 10 minutes maximum at 300° C. to about 1 hour at 95° C. The resulting material is useful in cementitious compositions, particularly mortars, these being characterised by a high flexibility and an exceptionally high degree of resistance to fire or heat.
Patent DE-69903426-T2 (DE)
Inventor: ERIKSON W
IPC: F16H25/20
Filed: 1999-05-26
Granted: 2003-06-26
Abstract: An anti-backlash mechanism is described in the form of a pair of nuts or nut halves with internal threads complementary to the threads on a lead screw. The mechanism is traslated by rotation of the screw. One of the nuts has an outer cantilevered wall with inner gear teeth which engage outer gear teeth on the other nut. Rotation of one nut with respect to the other nut tightens or loosens an abutting frictional rotation-opposing resistance of an elastomeric washer compressed between the two nuts. The compressed washer exerts a bias force against the nuts opposing axial forces exerted by the lead screw against the flanks of the nut threads.
Patent DE-69907258-T2 (DE)
Inventor: SHINAL C
IPC: A61K9/19
Filed: 1999-12-10
Granted: 2003-11-06
Abstract: The invention provides a method of preparing anhydrous disodium pamidronate or an aqueous disodium pamidronate solution for pharmaceutical use.
Patent DE-69910850-T2 (DE)
Inventor: ZYCH EDMOND
IPC: F02M63/00
Filed: 1999-01-27
Granted: 2004-07-29
Abstract: The system consists of a calibrated valve (6) in the excess fuel return pipe (5) in parallel with and close to the injection pump return port (4b), designed to give an increase in pressure in the pump port, and a normally-open one-way valve (7). The one-way valve (7), which is springloaded, is closed when the pressure in the port rises above that in the fuel feed pipe (2) before its non-return valve (3).
Patent DE-69912671-T2 (DE)
Inventor: ANDELFINGER GEORGES
IPC: A01B63/102
Filed: 1999-04-20
Granted: 2004-09-30
Abstract: The support comprises a mast pivoted by an actuator, with retaining arm pivoted by the actuator around a trunnion on a sleeve sliding on the mast, and height adjustment accomplished by the third actuator. The viticulture machine support comprises a mast (10) able to pivot around a shaft (11) in its lower part under the action of a hydraulic actuator (60). A retaining arm (40) is able to pivot around a trunnion (24) fixed on a sleeve, able to slide on the mast, under the action of a hydraulic actuator (70). The actuators are located at the top and bottom and on either side the mast axis so that the machine trim is automatically conserved during mast pivoting. Height adjustment of the machine is accomplished by an actuator (80) whose lower articulation shaft (81) is carried by a support (13) and its upper articulation shaft is connected to a support integral with the sleeve. A balancing pole (30) comprises rear (32) and a front (33) seats between which is a tubular element (31). The arms can be arranged on the front seat at different heights. The balancing pole is pivoted on a trunnion (24F) on the sleeve.
Patent DE-69917927-T2 (DE)
Inventor: ZAGAR A
IPC: F04B13/00
Filed: 1999-11-23
Granted: 2005-06-23
Abstract: A pump controller and pump controlling method for dispensing a precise amount of low viscosity fluid are provided in which the problems of double dispenses and stuttered dispenses are avoided. In particular, the timing of the valves and motors in the pumping apparatus are adjusted to avoid these problems.
Patent DE-69922977-T2 (DE)
Inventor: FILIC DARKO
IPC: A61P27/06
Filed: 1999-10-01
Granted: 2005-12-08
Abstract: New crystalline polymorph of torasemide, characterized by its powder x-ray diffraction pattern data; and its preparation by controlled acidification of alkaline torasemide solutions at specific temperatures and over specific periods. New crystal modification (form III) of torasemide, with spacings (d) between lattice planes, expressed in angstroms as 15.3898, 12.5973, 11.4565, 9.7973, 9.5493, 8.6802, 8.2371, 7.6351, 7.3356, 6.9759, 6.5351, 6.3240, 6.1985, 5.9521, 5.6237, 5.5623, 5.4040, 5.1119, 4.8738, 4.7865, 4.6986, 4.5985, 4.4602, 4.3405, 4.2552, 4.1829, 4.0768, 3.9377, 3.8659, 3.8429, 3.7801, 3.7248, 3.6239, 3.5556, 3.4825, 3.4130, 3.3055, 3.2298, 3.1786, 3.1278, 3.0699, 3.0078, 2.9549, 2.9056, 2.8541, 2.7686, 2.6988, 2.6610, 2.6293, 2.5549, 2.5236, 2.4485, 2.4161, 2.3671, 2.3133, 2.2788, 2.2312, 2.1852, 2.1468, 2.0957, 2.0617, 2.0273, 1.9896, 1.9688, 1.9274, 1.8853, 1.7931, 1.7449, 1.7169, 1.6512, 1.6122, 1.5601, 1.5320, 1.5057, 1.4521, and 1.3773. An independent claim is also included for the preparation of this new modification form III, by controlled acidification of an alkaline torasemide solution with inorganic or organic acids, with or without addition of a seed crystal, at a temperature of 0-35[deg]C within a period of 0.25-25 hours. ACTIVITY : Diuretic; cardiovascular; hypotensive; cardiant; ophthalmological; cytostatic; anticonvulsant; antiallergic; antiasthmatic. MECHANISM OF ACTION : None given.
Patent DE-69923990-T2 (DE)
Inventor: CURRY DOWNING
IPC: D06F39/02
Filed: 1999-10-22
Granted: 2006-04-06
Abstract: A product and process for laundering delicate or dry-clean only garments in a conventional home washing machine. The process represents a home version of the commercial wet-cleaning processes for cleaning of delicate garments. The product may comprise a liquid cleaning composition, a wash pretreatment composition, a wash pretreatment applicator, an apparatus for dispensing a rinse cycle conditioner and a flexible wrap container within which the garments are contained during washing.
Patent DE-69931124-T2 (DE)
Inventor: WATANABE YOSHIO
IPC: H04N1/405
Filed: 1999-10-25
Granted: 2006-11-23
Abstract: An interface section analyzes print data including data for identifying an object or data showing the setting of color processing and others and sets required color processing in units of a printed page. According to the set color processing, a color processing section sets corresponding color correction table and halftoning processing table in a high speed random access memory for example. The interface supplies a drawing instruction together with attribute data corresponding to the setting in the color processing section to a drawing section. The drawing section plots image data composed of color data every dot according to the drawing instruction and stores the drawing instruction together with the attribute data every dot in an image memory. The color processing section executes optimum or intended color processing for color data in the image memory, referring to a color correction table and a halftoning processing table respectively corresponding to its attribute data and generates image reproduction data. Accordingly, arbitrary color processing can be realized by a controller composed of light hardware. <IMAGE>
Patent DE-69933776-T2 (DE)
Inventor: BARNES ANTONY
IPC: C12N5/10
Filed: 1999-09-03
Granted: 2008-01-03
Abstract: The present invention relates to the novel GABAB receptor subtypes GABAB-R1c and GABAB-R2 as well as to a novel, functional GABAB receptor which comprises a heterodimer of GABAB-R1 and GABAB-R2 receptor subunits. The present invention also relates to variant of the receptors, nucleotide sequences encoding the receptors and variants thereof and novel vectors, stable cell lines, antibodies, screening methods, methods of treatment and methods of receptor production.
Patent HU-E034971-T2 (HU)
Title: Self-closing device for sliding doors
Inventor: TARREGA LLORET MIGUEL ANGEL
IPC: E05F1/16
Filed: 2012-04-27
Abstract: Self-closing device for sliding doors of the type comprising at least one sliding leaf (2) which is hung from an upper profile (3). Said device (1) comprises a drive belt (10) configured to be joined to the sliding leaf (2); a closing pulley (20), provided with elastic means (30), which is arranged on a first rotation axis (4) integral to the upper profile (3) and which engages with a first end (11) of the drive belt (10); and a brake pulley (40), provided with stopping means (50), which is arranged on a second rotation axis (5) integral to the upper profile (3) and which engages with a second end (12) of the drive belt (10) opposite to the first end (11), thus the rotation movement of both pulleys (20, 40) being connected by the drive belt (10).
Patent MD-3322717-T2 (MD)
Inventor: SCHUSTER HEIKO
IPC: C07K14/47
Filed: 2016-07-14
Abstract: Prezenta invenţie se referă la o peptidă, proteine, acizi nucleici şi celule pentru utilizare în metode imunoterapeutice. În particular, prezenta invenţie se referă la imunoterapia cancerului. În plus, prezenta invenţie se referă la un epitop peptidic al celulelor T citotoxice asociate tumorii, singuri sau asociaţi cu alte peptide asociate tumorii, care pot servi, de exemplu, drept componente farmaceutice active ale formulelor de vaccin care stimulează răspunsurile imunitare antitumorale sau pentru stimularea celulelor T ex vivo şi transferarea la pacienţi. Peptidele legate de molecule ale complexului major de histocompatibilitate (MHC), sau peptidele ca atare, pot fi, de asemenea, ţinte ale anticorpilor, ale receptorilor solubili ai celulelor T şi ale altor molecule de legare.
Patent TR-200000132-T2 (TR)
Title: Dolastatin 15 türevleri
Inventor: JANSSEN BERND
IPC: C12P19/34
Filed: 1998-07-07
Abstract: Mevcut bulusun bilesikleri Formül (1): A-B-D-E--F-(G)r-(K)s-L'nin peptitleri olan hücre büyüme inhibitörleri ve bunlarin asit tuzlarini içerir. Burada A,B,D,E,F,G ve K alfa-amino asit tortularidir ve s ve r'nin her biri ise bagimsiz olarak 0 veya 1'dir. L ise bir amino grup, bir N'nin yerini tutan amino grup, bir  -hidroksilamino grup, bir hidrozido grup, bir alkoksi drup, bir thioalkoksi grup, bir aminoksi grup veya bir oksimato grup dibi monovalent (tek degerlikli) bir radikaldir. Bu bulus ayni zamanda farmasötik olarak kabul edilebilen bir kompozisyondaki Formül (I)'in bir bilesiginin etkili bir miktarini insan gibi bir memeli hayvana tatbik etmekten olusan ve bir memeli hayvandaki kanser tedavisinde kullanilan bir metodu da ihtiva eder.
Patent TR-200001725-T2 (TR)
Title: Selenyumun rafineri işlem suyu ve atık su akıntılarından arındırılması için işlem
Inventor: OVERMAN STEVEN D
IPC: C02F1/52
Filed: 1998-10-15
Abstract: Bu bulus, çok çesitli rafineri islemine tabi tutulmus su ve atik su akintilarindan selenyumun ayrilmasi için verimli ve yüksek oranda etkin bir yöntem saglamaktadir. Bu bulus ayni zamanda metal oksit veya metal hidroksit çökelti üzerinde toplanmasi için selenyumun ve organo-selenyum bilesiklerinin selenit (+IV) oksitlenme haline oksitlenmesi için yeni ve etkin bir yöntem saglamaktadir. Bulus arda arda baglanmis, iki sürekli karistirilan tank tepkileyici (CSTR) ihtiva eder. Muamele edilecek akinti ve pekçok demir tuzlarindan (ferrik sülfat, ferrik klorit, v.b.) biri, ferrik hidroksit ve ferrik oksihidroksit çökelti olusturan birinci CSTR ye gönderilir. Birinci CSTR nin pH degeri ferrik tuzun enjeksiyon oranin ayarlanmasi ile otomatik olarak kontrol edilir. Birinci CSTR nin çikis, potasyum permanganatin verildigi ikinci CSTR ye yönlendirilir. Orjinal akintidaki muamele edilecek olan selenyum selenite (+IV) oksitlenir; manganez dioksit çökeltisi oksidasyon tepkimesinin ara ürünüdür.
Patent TR-200002395-T2 (TR)
Title: Mantar ilacı olarak kullanılan 2-piridilmetilamin türevleri
Inventor: MOLONEY BRIAN ANTHONY
IPC: C07D213/85
Filed: 1999-02-16
Abstract: Formül I'e ait terkipler ve bunlarin tuzlarinin nebati patojenik mantar ilaçlari olarak kullanimlari. Burada A1 ikameli 2-piridil; A2 ihtiyari olarak ikameli fenil; L-(C=O)-,-SO2- ya da -(C=); R1 hidrojen, ihtiyari olarak ikameli alkil ya da açil ve R2 hidrojen ya da ihtiyari olarak ikameli alildir.
Patent TR-200003789-T2 (TR)
Title: İkameli triazolo-piridazin türevi ve bundan yapılan farmasötik bileşimler.
Inventor: CARLING WILLIAM ROBERT
IPC: A61K31/5025
Filed: 1999-06-15
Abstract: 7-(1,1-Dimetiletil)-6- (2-etil-2H-1,2,4-triazol-3-ilmetoksi) -3-(2-flüorofenil) -1,2,4-triazolo[4,3-b] piridazin ve bunun farmasötik açidan kabul edilen tuzlari olup, GABAA reseptörleri için, özellikle alfa2 ve/veya alfa3 alt ünitesi için yüksek uyum gösteren seçici ligantlardir ve buna uygun olarak, anksiyete ve konvülsiyonu da içeren merkezi sinir sistemi hastaliklarinin tedavisi ve/veya önlenmesinde yararlidir.