Patent SG-11201900712S-A (SG)
Title: Memantine transdermal delivery systems
Inventor: LEE EUN SOO
IPC: A61P25/28
Filed: 2017-07-26
Abstract: 140 160 0 20 40 60 8C 100 Time (hr) FIG. 2 ac 2 tlJ C C ro E (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 February 2018 (01.02.2018) WIP0 I PCT onion °nolo III 1101 °nom° 1 ois (10) International Publication Number WO 2018/022818 Al (51) International Patent Classification: A61K 31/13 (2006.01) A61P 25/28 (2006.01) A61K 9/70 (2006.01) A61P 9/10 (2006.01) A61P 25/00 (2006.01) (21) International Application Number: PCT/US2017/044051 (22) International Filing Date: 26 July 2017 (26.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/367,502 27 July 2016 (27.07.2016) US 62/423,133 16 November 2016 (16.11.2016) US 62/444,745 10 January 2017 (10.01.2017) US 62/444,763 10 January 2017 (10.01.2017) US 62/457,791 10 February 2017 (10.02.2017) US 62/457,794 10 February 2017 (10.02.2017) US 62/504,391 10 May 2017 (10.05.2017) US (71) Applicant: CORIUM INTERNATIONAL, INC. [US/US]; 235 Constitution Drive, Menlo Park, California 94025 (US). (72) Inventors: LEE, Eun Soo; 2575 Hampton Avenue, Red- wood City, California 94061 (US). SINGH, Parminder; 5504 Alvelais Drive, Union City, California 94587 (US). SAGI, Appala; 2025 California Street #42, Mountain View, California 94040 (US). JAIN, Amit K.; 825 Carino Terrace, Milpitas, California 95035 (US). (74) Agent: MOHR, Judy M. et al.; McDermott Will & Emery LLP, 500 North Capitol Street, NM., Washington, District of Columbia 20001-1531 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = (54) Title: MEMANTINE TRANSDERMAL DELIVERY SYSTEMS - Memantine salt, sodium bicarb -c - Memantine free base 40 —0-- Memantine salt, no sodium bicarb a) A Memantine salt, altemative to sodium bicarb (57) : Transdermal delivery systems for the systemic delivery of memantine are described, wherein the system comprises a drug reservoir layer and an adhesive layer, optionally together with one or more intermediate and/or supporting layers, wherein the drug reservoir layer comprises an acrylate polymer or copolymer, a permeation enhancer, a carrier, and memantine base generated in situ by reaction of a memantine salt and an alkaline salt. Compositions and kits comprising the various components, e.g., drug reservoir and/or adhesive compositions are described. Methods relating to treatment of CNS disorders, e.g., Alzheimer's disease and/or dementia, using the aforementioned transdermal delivery devices and/or compositions are also described. [Continued on next page] WO 2018/022818 Al IMEDIMOMMIDIRE10101011010HOHHOHOMEMNIE HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))