baber/WOPTO huggingface dataset:
Patent IL-96094-A0 (IL)
Title: Gnrh analogs and their production
IPC: C07D249/14
Filed: 1990-10-24
Abstract: Peptides which include unnatural amino acides and which either inhibit or promote the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. Administration of an effective amount of such peptides that are GnRH antagonists prevents ovulation of female mammalian eggs and/or the release of steroids by the gonads. The antagonists may be used to treat steroid-dependent tumors, such as prostatic and mammary tumors. The peptides are analogs of the decapeptide GnRH wherein there is at least one residue of an unnatural amino acid in the 3-position, the 5-position, the 6-position and/or the 8-position. Such unnatural amino acids are useful in the synthesis of peptides and have the formula U*:  <IMAGE>  where n is an integer from 1 to 6; Y is N-CN, N-CONHR9, S, O or CH-NO2; R9 is H, Ac, lower alkyl, aromatic or heterocyclic; X is NH, O, S, M1(CHq)pM2 or M1-(CH2)p'-M2(CH2)p''-M3, where M1 is NR10, O, S or CHR3 wherein R3 is methyl, ethyl, propyl, phenyl, pyridinyl, pyrimidinyl or purinyl, q is 1 or 2; p, p' and p'' are integers between O and 6; R10 is H, lower alkyl or the like, and M2 and M3 are M1, COOH, CONH2, COOR3 or CN; R1 is H, alkyl, modified alkyl, alkenyl, alkynyl, aryl or a direct bond to X; R2 is R1, OH, NH2, NHR1, or heterocycle.
Patent IL-97455-A0 (IL)
Title: Contrast media
IPC: A61K49/04
Filed: 1991-03-06
Abstract: A contrast medium of aq. carrier, dissolved contrast agent and dissolved sodium cpd. providing a sodium ion concn. of 15-75 mM Na/l is characterised in that it also contains a dissolved calcium salt and opt. potassium and magnesium salts in a total concn. of up to 0.8 mM Ca/l and up to 2 mM K/l, the ratio of sodium ions to calcium ions being greater than 55. Pref. the Ca concn. is 0.05-0.7 mM Ca(2+)/l (esp. 0.1-0.6 mM Ca(2+)/l), the K concn. is 0.2-1.5 mM K(+)/l (esp. 0.3-1.2 mM K(+)/l) and the Mg concn. is up to 0.8 mM Mg(2+)/l (esp. 0.05-0.4 mM Mg(2+)/l). Pref. the contrast agent is iodinated e.g. iohexol, ioversol, iopamidol, iotrolan, ioxaglate or iodix anol.
Patent IL-97698-A0 (IL)
Title: Hydroxymethyl-indolizidines,quinolizidines and pharmaceutical compositions containing same
IPC: C07D455/02
Filed: 1991-03-27
Abstract: The present invention describes a group of polyhydroxylated indolizidines and quinolizidines and their esters. These compounds are prepared starting from 2,6-dideoxy-2,6-imino-1,3,4,5-tetrakis-O-(phenylmethyl)-D-glycero-L-gu lo-heptitol or a corresponding N-substituted compound. The compounds are useful in the treatment of diabetes and as  alpha -glucosidase I inhibitors.
Patent IL-97736-A0 (IL)
Title: Method for the protection of plants against pathogens
IPC: A01H5/00
Filed: 1991-03-31
Abstract: The invention comprises pathogen resistant plants, wherein a polynucleotide sequence comprising at least a sequence of a pathogenic avirulence gene (E) encoding a specific elicitor protein molecule (e) or a portion thereof is introduced into the genome of a plant containing a corresponding resistance gene (R), in which genes (E) and (R) are regulated in such a manner that simultaneous expression of said genes only occurs at the site of infection and said simultaneous expression can be induced by a broad range of pathogens. The plants have been transformed by a polynucleotide sequence comprising at least a sequence of an avirulence gene (E) from a plant pathogen encoding a specific elicitor protein molecule (e) or a portion thereof, and a plant promoter (P) that can be induced by a broad range of pathogens and which permits expression at the site of infection only. Plants wherein the resistance gene (R) is under control of a pathogen-inducible promoter (P) form another embodiment of the invention.
Patent IL-99569-A0 (IL)
Title: Copper hydroxide dry flowable bactericide/fungicide and method of making and using same
IPC: A01N59/20
Filed: 1991-09-26
Abstract: There is disclosed a granular copper hydroxide dry flowable bactericide/fungicide having improved biological activity and a method for making and using same. A bactericide/fungicide is made by forming a homogeneous aqueous slurry containing between approximately 5% and 20% by weight (based on the total weight of all dry ingredients) of a first dispersant selected from the group consisting of partially neutralized polyacrylic acid having a pH of between approximately 5 and 10 and an average molecular weight of between approximately 1,000 and 10,000 and lignin sulfonate, between approximately 0% and 5% by weight (based on the total weight of all dry ingredients) of a second dispersant for bentonite clay, between approximately 40% and 80% by weight (based on the total weight of all dry ingredients) phosphate stabilized cupric hydroxide and between approximately 6% and 30% by weight (based on the total weight of all dry ingredients) bentonite clay; and spray drying the slurry to thereby form a dry free flowing granular bactericide/fungicide product. The slurry can also include antifoam and wetting agents. Other partially neutralized polycarboxylic acid polymers useful as the first dispersant are also disclosed.
Patent FI-20055493-A0 (FI)
Inventor: PARO DANIEL
IPC: F01N11/00
Filed: 2005-09-16
Abstract: A method and arrangement in connection with a piston engine (1) provided with a turbocompressor (2), in which method combustion air is pressurized with a compressor (3), fuel is combusted in the cylinders (10) of the engine (1) with combustion air, and the exhaust gas formed at combustion is directed to the turbine (4). Additionally, the pressurized combustion air is moistened and mixing water therewith simultaneously cools the exhaust gas directed to the turbine (4).
Patent IL-113176-A0 (IL)
Title: Aqueous fuel for internal combustion engine and method of preparing same
IPC: C10L1/10
Filed: 1995-03-29
Abstract: An aqueous fuel having at least two phases for an internal combustion engine with 20-80 vol. % water, carbonaceous fuel, 2 to less than 20 vol. % alcohol, about 0.3 to 1 vol. % of a nonionic emulsifier, and which may contain up to about 0.1 vol. % of a fuel lubricity enhancer, and up to about 0.03 vol. % of an additive to resist phase separation at elevated temperatures. The fuel has an external water phase and is substantially nonflammable outside the engine. Also disclosed is a method of producing the fuel which includes mixing the carbonaceous fuel and emulsifier together prior to mixing with water and the other components.
Patent IL-126014-A0 (IL)
Title: Method of killing target cells in harvested cell populations with one or more immunotoxins
IPC: C12N5/00
Filed: 1997-03-12
Abstract: A method for killing unwanted target cells in a cell population comprising nucleated cells harvested from peripheral blood, or CD-34+ or similar early progenitor cells selected from the above nucleated cells or from bone marrow aspirates, in which method the cell population is in vitro or in vivo exposed to two or more immunotoxins selectively killing the malignant cells, is described. Furthermore the invention relates to the mixture of immunotixins, the use of the mixture and a kit for performing the method.
Patent IL-133253-A0 (IL)
Title: Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them
IPC: A61K31/409
Filed: 1999-12-01
Abstract: Novel C-13<SUP>2</SUP>-COXR<SUB>1</SUB>, C-17<SUP>2</SUP>-COXR<SUB>2 </SUB>and C-13<SUP>2</SUP>-COXR<SUB>1</SUB>, C-17<SUP>2</SUP>-COXR<SUB>1 </SUB>derivatives of chlorophyll and bacteriochlorophyll compounds are provided wherein X is O, S or N and R<SUB>1 </SUB>and R<SUB>2</SUB>, the same or different, may be an optionally substituted hydrocarbyl, amino acid, peptide, protein or saccharide radical. The compounds are for use in photodynamic therapy (PDT), for diagnosis of tumors, and for killing cells and infectious agents such as bacteria and virus, both in biological products and in living tissues.
Patent IL-135629-A0 (IL)
Title: Communication control device and method for cdma communication system
IPC: G08C17/00
Filed: 1999-08-17
Abstract: A device and method for communicating a common channel message in a CDMA communication system. The device comprises a base station transmitter and a common channel transmitter. The base station transmitter includes a specific channel transmitter for outputting a channel signal at a second transmission power level for a predetermined time duration and otherwise outputting the channel signal at a first transmission power level. The common channel transmitter transmits a common channel message at an assigned slot duration. A power supply voltage is provided to the receiver of the mobile station for the predetermined time duration and the assigned slot duration to enable the receiver. The power supply voltage to the receiver is otherwise disengaged from the power supply so as to allow the receiver to operate in a sleep mode.
Patent IL-137982-A0 (IL)
Title: Liquid polymeric compositions of controlled release of bioactive substances
IPC: A61K47/30
Filed: 1999-03-18
Abstract: Controlled release of hydrophobic bioactive substances in vivo over an extended time period and without "bursts" of drug release achieved using a liquid polymeric composition including a polymer such as poly(lactide-co-glycolide) copolymer in a mixture of hydrophilic and lipophilic solvents.
Patent IL-151783-A0 (IL)
Title: Dynamic heating and cooling of a building using liquid foam
IPC: F24D11/00
Filed: 2001-03-16
Abstract: A heating and cooling system and a method for controlling and regulating the temperature within a building envelope (10) having roof and wall cavities (14) adapted to receive replaceable foam liquid. The interior of the building envelope (10) is maintained at any specific controlled temperature by controlling the temperature of the liquid foam. The temperature of the liquid foam within the roof and wall cavities (14) is sensed and when a change in temperature is detected, a dynamic liquid foam regeneration unit is triggered so as to supply new liquid foam at an appropriate temperature so as to maintain the overall temperature of the liquid foam in the roof and wall cavities (14) substantially constant.
Patent IL-152804-A0 (IL)
Title: Methods for refolding proteins containing free cysteine residues
IPC: C07K14/00
Filed: 2001-05-16
Abstract: The present invention relates to novel methods for making and refolding insoluble or aggregated proteins having free cysteines in which a host cell expressing the protein is exposed to a cysteine blocking agent. The soluble, refolded proteins produced by the novel methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form PEGylated proteins.
Patent IL-158171-A0 (IL)
Title: Compositions and methods for cell separation
IPC: G01N33/567
Filed: 2002-03-07
Abstract: The invention provides compositions and methods for cell separation. These reagents and techniques specifically agglutinate cells via surface antigen recognition and can be used to recover even rare cell types in high yield.
Patent IL-159854-A0 (IL)
Title: Improved process for preparing benzimidazole-type compounds
IPC: C07D401/12
Filed: 2002-07-09
Abstract: The present invention relates to an improved process for the preparation of proton pump inhibitors of the benzimidazole-type such as rabeprazole, omeprazole, pantoprazole, lansoprazole and esome prazole, of general formula (1) by oxidation of the corresponding sulfide followed by extraction of the sulfone by-product with an aqueous alkaline solution at controlled pH.
Patent IL-178178-A0 (IL)
Title: Improved packaging method that causes and maintains the preferred red color of fresh meat
IPC: A23L13/00
Filed: 2006-09-19
Abstract: The present invention is a method for improving the visual appearance of a food product (12) and a film (22) utilized in the method. The film includes an effective amount of a nitrogen-containing compound contained within or applied to one side of the film and adapted to contact a food item held within a food packaging container (10). Upon contacting the food item within the container, the nitrogen-containing compound forms nitrous oxide gas within the container, because of the contact of the compound with and dissolution into the juices of the food product. Thus, the physical contact of the packaging film with the food product causes a preferred reddish bloom to appear on the viewing surface (100) of the food item without effecting the appearance, performance or color of the interior of the food product.
Patent IL-194812-A0 (IL)
Title: Integrated wound dressing system
Filed: 2008-10-22
Abstract: An integrated wound dressing system and method including a bandage and a self-contained receptacle that stores treatment material for the care and treatment of wounds. The treatment material is easily accessible and can be removed from the receptacle through an exit. The treatment material can then be used to control bleeding and/or clean the wound before dressing. The bandage may include a layer of plastic that acts as an occlusion barrier to reduce heat loss and maintain moisture levels at the wound site. The occlusion barrier also acts to prevent the passage of air into or out of the wound site. The bandage also includes fasteners that act to prevent unintentional unraveling and to secure the bandage during final packaging. These fasteners help facilitate the wrapping of amputations, stumps, and extremities. The integrated wound dressing system provides an all-in-one system for treating and dressing wounds and reduces the time required to do so.
Patent IL-208903-A0 (IL)
Title: Nociceptin analogs
IPC: A61P43/00
Filed: 2010-10-24
Abstract: Compounds of formula (IV) as ORL1 modulators for the treatment of pain.
Patent RO-129542-A0 (RO)
Title: Device with retractable chains actuated from the board with a view to eliminating car skid
Inventor: POPA PAVEL
IPC: B60C27/00
Filed: 2014-02-24
Abstract: The invention relates to a device with retractable chains actuated from the board for eliminating car skidding when the practicable road is covered with glazed frost, snow or ice. According to the invention, the device comprises a supply system (), an extensible element (), a housing () and some retractable chains () where, for a better efficiency of the retractable chains () they can be mounted both crosswise and lengthwise onto the tire, the supply system () supplies the protective device with electric energy by means of a supply cable (), the extensible element () allowing the change of the length of the supply cable () depending on the position of the telescopes, in case of ground unevenness, and, consequently, on the position of the wheel as against the car body (wing) and comprising a spring which has the first and the last turn integral with the supply cable (), between the first and the last turn of the spring, the supply cable () having a reserve necessary for the extension, and the housing () has a protective role combined with aesthetic valences, the retractable chains () being actuated by means of some strands () and moving along some guiding channels (), which are mounted crosswise onto the tire, within the space resulting after making some cutouts therein.
Patent RO-132215-A0 (RO)
Title: Heating module with low electric energy consumption
Inventor: MUSCALU VASILE
IPC: F24J3/00
Filed: 2017-02-01
Abstract: The invention relates to a heating module with low electric energy consumption for producing thermal energy needed to heat a dwelling house, which transfers the generated heat to a liquid wherein it is immersed, the heat being delivered by natural convection, heating the air in the room in which it is located. According to the invention, the module consists of a metallic cavity (A), preferably made of copper or aluminum, inside of which there is a module (B) consisting of a group of semiconductor elements, some metallic rods (C), fixed into the module (A) by welding, at the upper side there being a metallic cavity (D) tightly fixed onto the rods (C), a temperature controller module (E), a module (F) wherein a step-down transformer is placed, an electronic module (G) for controlling the module (B), and inside the cavity (A) and the rods (C), there is transformer oil up to a level (a), where the cavity (A) is a metallic pipe, preferable made of copper or aluminum, wherein some rods (C), soldered or welded, are introduced, and, at the upper side there is a cavity (D), wherein the rods (C) are introduced to form a central-heating radiator or a heat radiator, at the lower side of the cavity (A) there being a module (B), in connection with some metallic rods (1, 2 and 3), for supplying some semiconductors (4), the pins of which are introduced by soldering in a printed circuit (5), preferably of glass-textolite, the rods (1, 2 and 3) passing through a metallic flange (6), through some lead-through insulators (7, 8 and 9), and, at the right extremity of the cavity (A), there is fixed a flange (10), with holes meant to seal the central-heating radiator by clamping with some screws (21) and nuts (22), the controller (E) having a sensor (11) on one of the rods (C), through a metallic conductor (12) insulated at the outside in order to precisely measure the temperature.
Patent RO-137303-A0 (RO)
Title: Stand and method for static and dynamic testing of violins
Inventor: STANCIU MARIANA DOMNICA
IPC: G01N29/22
Filed: 2022-10-04
Abstract: The invention relates to a stand and a method for static and dynamic testing of violins. According to the invention, the stand comprises a mechanical component (A) consisting of a device for fixing a violin (1) and a bow (5), an angular adjustment system (2), a support (3) on which the violin neck rests, a longitudinal guide (4), an electric component (B) consisting of the bow (5), a linear bearing (6) and an electric motor (7) for driving the bow in such a way as to produce the excitation of the strings, and an electronic component (C) consisting of systems for identifying and recording the relative geometric position between the violin (1) and the bow (5) by means of a position sensor (C1), the tension in the tuned strings by means of a force sensor (C2), the pressure of the bow in contact with the strings by means of a pressure adjustment sensor (C3), a system (C4) for generating rectilinear reciprocating motion for driving the bow and a means (C5) for recording acoustic vibrations, having dedicated sensors that transmit signals to an acquisition board and to a computer (13).
Patent RO-137676-A0 (RO)
Title: Installation for charging batteries with energy multiplier
Inventor: LEONTE VIOREL
IPC: H02K53/00
Filed: 2023-04-03
Abstract: The invention relates to an installation for charging batteries. According to the invention, the installation comprises an energy multiplier consisting of a generator reduction gear motor comprising a drive wheel (2) mounted on the shaft of a driving electric motor (1) supplied by a controller (6) and which transmits the rotation movement, through a transmission belt (4), to a driven wheel (3) mounted on the shaft of an energy-producing generator (5), which is further transmitted to a general control device (9) and charges a pack of batteries (8).
Patent MA-28034-A1 (MA)
Title: Derives de malonamide bloquant l 'activite gama-secretase
Inventor: FLOHR ALEXANDER
IPC: A61K31/5513
Filed: 2006-03-10
Abstract: DERIVES DE MALONAMIDE BLOQUANT L'ACTIVITE DE LA GAMMA-SECRETASE L'invention concerne des dérivés de malonamide de formule (I), dans laquelle : R1 est un des groupes suivants (formules a) , b), c), d)) ; R2 est un radical alkyle inférieur, alcynyle inférieur, -(CH2)n-O-(alkyle inférieur), -(CH2)n-S-(alkyle inférieur), -(CH2)n-CN, - (CR¿R")n-CF3, - (CR'R")n-CHF2, -(CR'R")n-CH2F, -(CH2)n-C(O)O-(alkyle inférieur), -(CH2)n-halogéno ou est -(CH2)n-cycloalkyle, éventuellement substitué par un ou plusieurs substituants, choisis dans l'ensemble constitué par les halogènes et les radicaux phényle ou CF3 ; R',R" sont, indépendamment de n et l'un de l'autre, l'hydrogène, un radical alkyle inférieur, alcoxy inférieur, un halogène ou un radical hydroxy ; R3, R4 sont indépendamment l'un de l'autre l'hydrogène, un radical alkyle inférieur, alcoxy inférieur, phényle ou un halogène ; R5 est l'hydrogène, un radical alkyle inférieur, -(CH2)n-CF3 ou -(CH2)n-cycloalkyle ; R6 est l'hydrogène ou un halogène ; R7 est l'hydrogène ou un radical alkyle inférieur ; R8 est l'hydrogène, un radical alkyle inférieur, alcynyle inférieur, (CH2)n-CF3, -(CH2)n-cycloalkyle ou -(CH2)n-phényle, éventuellement substitué par un halogène ; R9 est l'hydrogène, un radical alkyle inférieur, -C(O)H, (C(O)-(alkyle inférieur), -C(O)-CF3, -C(O)-CH2F, -C(O)-CHF2, -C(O)-cycloalkyle, -C(O)-(CH2)n-O-(alkyle inférieur), -C(O)O- (CH2)n-cycloalkyle, -C(O)-phényle, éventuellement substitué par un ou plusieurs substituants choisis dans l'ensemble constitué d'un halogène ou de -C(O)O-(alkyle inférieur), ou est -S(O)2-(alkyle inférieur), (S(O)2-CF3, -(CH2)n-cycloalkyle ou est -(CH2)n-phényle, éventuellement substitué par un halogène ; n est 0, 1, 2, 3 ou 4 ; et des sels d'addition d'acide acceptables d'un point de vue pharmaceutique, des énantiomères optiquement; purs, des racémates ou un mélange diastéréoisomérique de ceux-ci. Ces composés peuvent être utilisés pour le traitement d'une maladie d'Alzheimer.
Patent MA-39796-A1 (MA)
Title: Procédé et dispositif pour la décharge d'un réservoir d’hydrogène dans les capteurs cylindro-paraboliques
Inventor: DR THOMAS KUCKELKORN
IPC: F24S23/74
Filed: 2017-01-26
Abstract: La présente invention décrit le procédé de déchargement d'un système de stockage de l'hydrogène logé dans l'espace annulaire (3) d'un tube récepteur (4), en particulier des capteurs solaires, dans lequel l'espace annulaire (3) est formé entre le revêtement tubulaire externe (2) et le tube absorbeur interne (1) du tube récepteur(4), et la couche externe du revêtement (2) est connecté par une paroi (5) au tube absorbeur (1) de manière étanche au gaz. Le procédé est caractérisé par les présentes en ce qu'une ouverture (01) pénétrant dans le revêtement tubulaire (2) ou la paroi (5) est produite, l'hydrogène libre dans l'espace annulaire (3) est évacué à travers l'ouverture (01) et l'ouverture (01) est ensuite scellée. L'invention décrit en outre un dispositif (100) pour la mise en oeuvre du procédé.
Patent MA-41401-A1 (MA)
Title: Formation de faisceau
Inventor: SELEN YNGVE
IPC: H04B7/06
Filed: 2015-05-13
Abstract: Des pondérations d'antenne d'une pluralité de directions en forme de faisceau (251, 252) sont déterminées. La transmission sur la première direction en forme de faisceau (251) est rendue prioritaire par rapport à la transmission sur la seconde direction en forme de faisceau (252), par exemple lors d'un balayage de faisceau. De telles techniques peuvent trouver une application dans la découverte d'un nœud d'accès (122) par un dispositif (130) rattaché à un réseau sans fil.
Patent MA-49426-A1 (MA)
Title: Processus à haut rendement pour la production d’antivenins à partir de fragments d’anticorps f(ab') 2
Inventor: GONZÁLEZ CANUDAS JORGE ALEJANDRO
IPC: C07K16/18
Filed: 2017-10-02
Abstract: La présente invention concerne le domaine des produits d’origine biologique basée sur la fragmentation d’anticorps qui s’utilisent pour une immunisation passive afin de neutraliser les toxines présentes dans les venins des animaux vénéneux, notamment un produit biologique dont le principe actif est une combinaison de fragments d’anticorps f(ab')2 et le procédé d’obtention de celui-ci avec un rendement élevé et une meilleure qualité quant à la pureté et à la capacité neutralisante de ces toxines. L'invention décrit également leur purification à partir de plasma hyperimmun par relargage sans crésol, thermocoagulation ni dialyse et par application de techniques d’ultrafiltration avec des paramètres spécifiques pour obtenir des fragments de f(ab')2 de puretés supérieures à 95%.