Patent GB-651194-A (GB)
Title: Improvements in or relating to methods of preparing emulsions, in water or an aqueous medium, of vitamins, provitamins and vitamin or provitamin concentrations, soluble i n fat
IPC: A61K31/07
Filed: 1946-09-20
Abstract: Aqueous emulsions of fat-soluble vitamins, provitamines, or their concentrates are prepared with an emulsifying agent constituted by a sterol having an aliphatic side-chain of at least 4 carbon atoms at carbon atom 17, said sterol having had introduced into it one or more hydrophile groups by esterifying or alkoxylating its hydroxyl group by means of suitable compounds. Examples describe the emulsification of (1) a crude irradiation product containing vitamin D3 by means of the trisodium salt of butane-1,2,3,4-tetracarboxylic mono-cholesteryl ester; (2) a solution of vitamin D2 in arachis oil by means of cholesteroxy-methyl-triethyl ammonium chloride; (3) an alcoholic solution of ergosterol by means of the sodium salt of phthalic mono-cholesteryl ester, and (4) an acetone solution of a carotene concentrate by means of the trisodium salt of butane-1,2,3,4-tetra carboxylic monocholesteryl ester.  Other emulsifying agents specified are the sodium salt of acetylcitric acid mono-cholesteryl ester, the sodium salt of succinic mono-cholesteryl ester, the ethyl chloride quaternary salt of diethylamine acetoxy cholesterol, the potassium salt of cyclohexane - 4 - dicarboxylic - 1,2 - mono-chlesteryl ester, the a -glycerol phosphoric mono-cholesteryl ester, the sodium salt of the latter, and the sodium salt of the phthalic monoester of a sterol mixture from the unsaponifiable part of the fat of the mussel (mytilus eculis).ALSO:Aqueous emulsions of fat-soluble vitamins, provitamines, or their concentrates are prepared with an emulsifying agent constituted by a sterol having an aliphatic side-chain of at least 4 carbon atoms at carbon atom 17, said sterol having had introduced into it one or more hydrophile groups by esterifying or alkoxylating its hydroxyl group by means of suitable compounds. Examples describe the emulsification of (1) a crude irradiation product containing vitamin D3 by means of the trisodium salt of butane-1, 2, 3, 4 tetracarboxylic mono-cholesteryl ester, (2) a solution of vitamin D2 in arachis oil by means of cholesteroxy-methyl-triethyl ammoonium chloride, (3) an alcoholic solution of ergosterol by means of the sodium salt of phthalic mono-cholesteryl ester, and (4) an acetone solution of carotene concentrate by means of the tri-sodium salt of butane-1, 2, 3, 4-tetra carboxylic conocholesteryl ester. Other emulsifying agents specified are the sodium salt of acetyl-citric acid mono-cholesteryl ester, the sodium salt of succinic mono-cholesteryl ester, the ethyl chloride quaternary salt of diethylamino acetoxy cholesterol, the potassium salt of cyclohexane-4-dicarboxylic-1, 2,-mono-chlesteryl ester, the a-glycerol phosphoric mono-cholesteryl ester, the sodium salt of the latter, and the sodium salt of the phthalic mono-ester of a sterol mixture from the unsaponifiable part of the fat of the mussel (mytilus eculis).  The resulting emulsions may be added to foodstuffs or milk, or may be administered by injection.