baber/WOPTO huggingface dataset:
Patent DE-69131321-D1 (DE)
Inventor: GELFAND DAVID
IPC: C12Q1/68
Filed: 1991-09-30
Granted: 1999-07-15
Abstract: The present invention provides novel thermostable DNA polymerase enzymes. These polymerase enzymes preferably have the amino acid sequence of SEQ ID NO:6 or SEQ ID NO:8, or of a sub-sequence thereof lacking up to one third of the sequence at the N-terminus of SEQ ID NO:6 or SEQ ID NO:8. The invention also provides DNA sequences which encode said thermostable DNA polymerases, as well as recombinant DNA vector comprising such a DNA sequence, and host cell transformed with a vector comprising such a DNA sequence. Also provided are a process for the preparation of said thermostable DNA polymerases and stabilized preparation comprising such a thermostable DNA polymerase in a buffer containing one or more non-ionic polymeric detergents. The thermostable DNA polymerases of the invention or the stabilized preparations comprising same are preferably used for amplifying or sequencing a nucleic acid and are preferably sold in a kit configuration.
Patent DE-69132580-D1 (DE)
Inventor: NEGI SHIGETO
IPC: C07D501/00
Filed: 1991-11-08
Granted: 2001-05-17
Abstract: A compound represented by the following formula (1a): a process for the preparation thereof, an antibacterial composition comprising the same and the use thereof for the preparation of a medicament and for the synthesis of related cephem compounds.
Patent DE-69133369-D1 (DE)
Inventor: MARKOLL DR
IPC: A61N2/04
Filed: 1991-05-06
Granted: 2004-04-01
Abstract: The present invention relates to an apparatus for treating a body organ by applying a magnetic field by way of an annular coil (T) surrounding the body organ, wherein the apparatus comprises a horizontal transitional surface (14), supporting means for the body organ arranged within the opening of the coil and at least one track (26) arranged at a level below the supporting means for moving the coil and the supporting means relative to each other.
Patent DE-69205018-D1 (DE)
Inventor: OOI KATHERINE BEE YONG
IPC: A63B59/00
Filed: 1992-01-28
Granted: 1995-11-02
Abstract: A device for relieving tennis elbow and that is mountable on the strings of a sports racquet, the device being defined by an elongated flexible, rubber-like strap (12) having dampening characteristics and that is formed with a plurality of transversely extending external ribs (18,22) thereon in spaced apart longitudinal relation, the flexible strap (12) being interwoven between adjacent longitudinally extending strings (34) of the racquet, wherein the ribs (18,22) as formed on the flexible strap (12) define stops for locating the flexible strap (12) in a positive position on the longitudinally extending strings (34) for preventing the lateral shifting of the flexible strap (12) thereon. <IMAGE>
Patent DE-69210604-D1 (DE)
Inventor: PECHERER EUGENI
IPC: H01M12/06
Filed: 1992-09-15
Granted: 1996-06-13
Abstract: The invention provides a refueling system for automated recharging of zinc-air batteries of the type having a plurality of active zinc anode elements formed of active zinc material attached to a support frame immersed in an aqueous alkaline electrolyte in a battery casing, each anode element being in alternate array with an air cathode, the system comprising automated means for simultaneously separating a plurality of spent anodes from the casing, means for removing used electrolyte from the casing, transport means for conveying spent anodes to an anode processing station, the anode processing station, at which zinc which has been at least partly oxidized is removed from the support frame, means for attaching new or reconstituted active zinc material to a cleaned support frame to form an active zinc anode, automated means for simultaneously introducing a plurality of active zinc anodes into the casing, and means for introducing fresh electrolyte into the casing. <IMAGE>
Patent DE-69227493-D1 (DE)
Inventor: YADA TOSHIKAZU
IPC: C12N5/07
Filed: 1992-08-28
Granted: 1998-12-10
Abstract: An agent for the formation of spheroids of hepatocytes, which comprises a covalently lipid-bound glycosaminoglycan, and a culturing process for the formation of the spheroids. Hepatocytes spheroids can be formed by culturing hepatocytes in a culture vessel using a lipid-bound glycosaminoglycan as a culture substrate. Floating spheroids of hepatocytes can be obtained efficiently, which are capable of maintaining liver-specific functions and of keeping the spheroid form stably for a prolonged period of time.
Patent DE-69229703-D1 (DE)
Inventor: GLUECK REINHARD
IPC: A61P31/16
Filed: 1992-05-08
Granted: 1999-09-09
Abstract: Disclosed are immunostimulating reconstituted influenza virosomes (IRIVs) comprising reconstituted functional virus envelopes containing an inactivated hepatitis A virus and an influenza hemagglutinin protein (HA) or a peptide with the amino terminal 21 amino acid residue segment of HA2 which induces the fusion of the IRIVs with cellular membranes and the lysis of the IRIV. A vaccine containing the hepatitis A IRIVs is also disclosed.
Patent DE-69232841-D1 (DE)
Inventor: SCHARF DAVID
IPC: H01J37/28
Filed: 1992-07-22
Granted: 2002-12-12
Abstract: A color synthesizing scanning electron microscope having a scanning primary beam of electrons directed toward a specimen, is configured to produce color images of high information content. The microscope comprises at least two wide energy bandwidth secondary electron detectors, arranged around the specimen at predetermined variable angles, for receiving electron emission from the specimen subsequent to incidence of the scanning primary electron beam. The wide energy bandwidth secondary detectors detect electrons with trajectory or positional differences and convert the positional differences to signals for synthesizing color. The signals from the wide energy bandwidth secondary electron detectors are combined to generate signals representative of different colors. Additional signals representing a difference between any two input signals from the wide energy bandwidth secondary detectors can also be generated.
Patent DE-69301618-D1 (DE)
Inventor: AXELSSON OSKAR
IPC: C07D235/06
Filed: 1993-03-24
Granted: 1996-04-04
Abstract: The present invention discloses compounds of the formula <CHEM>  wherein     X is C or N;     Y is C or N;     R<1><1> is hydrogen, hydroxy, or alkoxy; R<1><2> and R<1><3> are each independently hydrogen; halogen; CF3; CN; OH; alkyl; cycloalkyl; cycloalkylalkyl; alkenyl; alkynyl; alkoxy; phenylalkyl; amino; nitro; sulphamoyl; pipiridyl; pyrrolidinyl; acyl; CO2H; CO2-alkyl; CO-amino; NH-CO-alkyl; phenylsulphonyl which may be substituted with halogen, CF3, CN, OH, alkyl, alkenyl, alkynyl, alkoxy, amino, or nitro; phenyloxy which may be substituted with halogen, CF3, CN, OH, alkyl, alkenyl, alkynyl, alkoxy, amino, or nitro; phenylamino which may be substituted with halogen, CF3, CN, OH, alkyl, alkenyl, alkynyl, alkoxy, amino, or nitro; or aryl which may be substituted one or more times with halogen, CF3, CN, OH, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, phenoxy, phenylalkyl, amino, nitro, sulphamoyl, pipiridyl, pyrrolidinyl, CO2H, CO2-alkyl, CO-amino, or NH-CO-alkyl; and R<4>, R<5>, R<6> and R<7> are each independently hydrogen; halogen; amino; nitro; CN; CF3; COOH; COO-alkyl; alkyl; acyl; alkoxy; -(CH2)n,-OH wherein n is 0, 1,2, or 3; -(CH2)m-O-alkyl wherein m is 0, 1,2, or 3; -(CH2)o-O-acyl wherein o is 0, 1,2, or 3; and that if X is N then R<4> is absent and that if Y is N then R<7> is absent;  or a pharmaceutically-acceptable addition salt thereof The compounds are useful as pharmaceuticals, for example, in the treatment of stroke, ischemia, anoxia, migraine and psychosis.
Patent DE-69303748-D1 (DE)
Inventor: ZARA RENATO
IPC: F01N13/18
Filed: 1993-03-29
Granted: 1996-08-29
Abstract: The method for obtaining mufflers for motor vehicles entails the steps of manufacturing pipes (2,3) each provided with a perforated end (4a,4b) clamped to separator endplates (6a,6b,6c,6d); manufacturing a first half-shell (7) and a second half-shell (8) provided with first and second half-sleeves (12a,12b) for the exit of the imperforate and appropriately shaped end of the pipes (2,3); assembling, by seaming, the first and second half-shells (7,8) so as to define a container, and; sealing the container at the first and second half-sleeves (12a,12b) and at the seam defined between the half-shells (7,8). The method thus allows to obtain a muffler which has no welds. <IMAGE>
Patent DE-69305741-D1 (DE)
Inventor: ANDREI MARIA
IPC: H01M6/18
Filed: 1993-08-13
Granted: 1996-12-05
Abstract: A solid, polymeric electrolyte is prepared by:     1) blending:     (a) a macromer of formula (I) <CHEM> wherein R = methyl, ethyl, n is an integer comprised within the range of from 2 to 20, x is an integer comprised within the range of from 2 to 5;   (b) a difunctional comonomer of formula (II>  CH2=C(CH3)COO(CH2CH2O)m-CO-(CH3)C=CH2   wherein m is an integer comprised within the range of from 2 to 5; with a molar ratio of the macromer (I) to the difunctional comonomer (II) comprised within the range of from 98:2 to 60:40; (c) an ionic compound in an amount comprised within the range of from 1 to 30% by weight; (d) an oligomer or a dipolar aprotic liquid in an amount comprised within the range of from 0 to 80% by weight; (e) a photoinitiator in an amount comprised within the range of from 0 to 10% by weight;   2) applying the above mixture on an inert support and exposing it to a source of ultraviolet light, thermal radiations, or electron beam.   <IMAGE>
Patent DE-69308860-D1 (DE)
Inventor: STANA NILS
IPC: F16L3/22
Filed: 1993-08-24
Granted: 1997-04-17
Abstract: PCT No. PCT/NO93/00130 Sec. 371 Date Feb. 24, 1995 Sec. 102(e) Date Feb. 24, 1995 PCT Filed Aug. 24, 1993 PCT Pub. No. WO94/04861 PCT Pub. Date Mar. 3, 1994A fixing device for securing an elongate article such as a conduit to a support structure such as a wall of a cableway or cable riser, includes a housing provided with opposed hooks for securing the housing to the support structure by relative movement and then locking in place of the hooks. After the housing is mounted, the elongate article can be received in a U-shaped jaw provided on the housing, and a ratchet arm pivoted and latched to the housing, around the elongate article, trapping the elongate article in the jaw. Freeing the elongate article and dismounting the fixing device involve a reversal of these steps.
Patent DE-69314253-D1 (DE)
Inventor: AKAGI YASABURO
IPC: A61K9/50
Filed: 1993-07-22
Granted: 1997-11-06
Abstract: A novel microparticle preparation comprising microparticles of a polymer which contain a drug and are at least partially or wholly coated with a water-soluble inorganic salt, a water-soluble organic acid or a water-soluble salt of an organic acid, which acts as an agent for preventing aggregation of the microparticle preparation is disclosed. The preparation is produced by spraying a polymer solution containing a drug and a solution or dispersion of a water-soluble inorganic salt, a water-soluble organic acid or a water-soluble salt of an organic acid from different nozzles and contacting them with each other in a spray dryer. In this procedure, if desired, a non-ionic surfactant may be added to the solution of the water-soluble inorganic salt, the water-soluble organic acid or the water-soluble salt of organic acid, or a solution of non-ionic surfactant may be sprayed from the other nozzle simultaneously.
Patent DE-69315107-D1 (DE)
Inventor: PRONI ALBERTO
IPC: F16B5/02
Filed: 1993-03-04
Granted: 1997-12-18
Abstract: The present invention relates to an adjustable spacer for installing door- and window-frames, which includes a body 2 which engages a portion of a profiled element 3 and a grub screw 4 which is connected to the body so that it can rotate. The body furthermore has a means 6 for connecting to a hole 5 defined in the portion of the profiled element. <IMAGE>
Patent DE-69317754-D1 (DE)
Inventor: CHABLAIX RENE EUGENE
IPC: A23P30/40
Filed: 1993-01-09
Granted: 1998-05-07
Abstract: The present invention relates to a process for making a food product which may be provided in the form of a whipped mass and which is capable of being used as a dressing in a composite product consisting, moreover, of an oven product. The invention also relates to the whipped food product obtained and the final composite product.
Patent DE-69319241-D1 (DE)
Inventor: DREAN HENRI
IPC: G21C19/02
Filed: 1993-04-29
Granted: 1998-07-23
Abstract: A device for supporting and positioning tools used in nuclear reactor vessel cover adaptors, including a carriage (6) supporting at least one tool, as well as a means for rotationally and translationally positioning said carriage.
Patent DE-69321593-D1 (DE)
Inventor: DORNBUSCH ARTHUR
IPC: A45D40/16
Filed: 1993-08-02
Granted: 1998-11-19
Abstract: A sample/trial size package for cosmetic stick-form products, such as deodorants. The package is especially adapted for use with the fill/invert method of manufacture. The product is secured within the package in a fixed position throughout its use. The package has a base for holding the product. The base comprises an enclosed body, a closed bottom and an open top. The base further includes a stalk axially oriented within it. The stalk defines a trough along the inside perimeter of the base between the stalk and the body. Lastly, the package has a cap for sealing the open top of the base when the package is not in use.
Patent DE-69322240-D1 (DE)
Inventor: PIERCE J MICHAEL
IPC: C12N15/54
Filed: 1993-06-29
Granted: 1999-01-07
Abstract: The present invention provides a substantially purified UDP-N-acetylglucosamine: alpha -6-D-mannoside  beta -1,6-N-acetylglucosaminyltransferase (GlcNAc T-V; EC 2.4.1.155) and antibodies which specifically bind GlcNAc T-V. The present invention also provides polynucleotide sequences and oligonucleotide probes capable of specifically hybridizing to nucleic acid sequences which encode GlcNAc T-V, and cDNA and genomic clones encoding GlcNAc T-V, as well as nucleotide sequences encoding GlcNAc T-V, as specifically exemplified by a GlcNAc T-V coding sequence from rat.
Patent DE-69330277-D1 (DE)
Inventor: RICHTER ANNA M
IPC: A61P31/00
Filed: 1993-09-20
Granted: 2001-07-05
Abstract: A method destroys or impairs target cells that have selectively accumulated a photosensitizing agent. The target cells are in the bloodstream of an intact animal, which bloodstream and animal further contain non-target cells. Radiation is applied transcutaneously to at least a portion of the intact animal at an intensity effective to impair or destroy selectively the target cells and to leave non-target cells relatively unimpaired. Target cells include leukemia cells, virus-containing cells, parasite-containing cells, and microorganisms such as bacteria, parasites and free viruses.
Patent DE-69331084-D1 (DE)
Inventor: DANIEL STOLL
IPC: H01H13/70
Filed: 1993-08-05
Granted: 2001-12-13
Abstract: The invention relates to a security device intended for opening and/or closing at least one door of a motor vehicle, characterised in that it includes:   - at least one operating keypad (2) built into the bodywork of the vehicle and intended for the introduction of an opening and/or closure code, the said keypad being equipped with sensor elements (6) sensitive to the touch and delivering a code corresponding to the keys activated; - a circuit (30, 32, 34, 44) capable of generating a control signal in response to the said code delivered by the control keypad; and - actuating means (36, 38) controlled by the said control signal and providing the locking and/or the unlocking of the said door.   <IMAGE>
Patent DE-69333876-D1 (DE)
Inventor: KIKINIS DAN
IPC: G09G5/18
Filed: 1993-11-29
Granted: 2006-02-02
Abstract: A computer system (233) comprising a central processing unit (CPU) (115;215), input apparatus (245, 251, 257), a video monitor (347; 447; 547), and comprising timer means (259) for monitoring activity of said input apparatus (245, 251, 257); signalling means (217) for signalling the video monitor to assume an alternative power state in response to output from the timer means; and power management means (339) for removing power from power using circuits in the monitor (347; 447; 547); characterised in that the video monitor (347; 447; 547) is capable of entering any one of two or more reduced power states in response to a specific command sent by the signalling means, in that specific commands are associated in the video monitor with specific reduced power states, and in that the video monitor enters an appropriate state according to the command sent by the signalling means.
Patent DE-69400385-D1 (DE)
Inventor: BRANELLEC JEAN-FRANCOIS
IPC: A61P7/02
Filed: 1994-05-06
Granted: 1996-09-26
Abstract: Heparin fractions obtained by nitrous depolymerisation, containing not more than 150 ppb of total nitroso compounds, prepared by subjecting heparins depolymerised by using a nitrite to the action of UV radiation.
Patent DE-69406832-D1 (DE)
Inventor: CONTE GINO
IPC: A63C17/06
Filed: 1994-02-01
Granted: 1998-01-02
Abstract: A supporting frame (1), particularly for aligned wheels (3) of skates, which is shaped like a "U" on the wings (2a,2b) of which there is a plurality of first and second holes (4,5) having the same axis. These holes constitute seats for removable pivots (6) for the wheels and are respectively partially closed and temporarily closeable at their opposite ends. A sliding bar (9), slideable in a groove (8), is used for blocking, at least temporarily, the pivots (6). The wheels are associable with the supporting frame without requiring screws and thus containing the assembly and general costs of the skate. <IMAGE>
Patent DE-69409023-D1 (DE)
Inventor: VANHOYE DIDIER
IPC: C08F220/14
Filed: 1994-04-06
Granted: 1998-04-23
Abstract: The process consists in copolymerising a hard monomer such as methyl methacrylate and a flexible monomer such as butyl acrylate, in the presence of methacrylic anhydride. Application to paints.
Patent DE-69410273-D1 (DE)
Inventor: MUCKENFUHS DELMAR
IPC: A47K10/32
Filed: 1994-07-25
Granted: 1998-06-18
Abstract: The present invention pertains to improved pop-up dispensing systems in which edge portions of adjacent towels are non-parallel when the individual towel sheets are interleaved and folded. This new configuration provides improved pop-up dispensing reliability by providing a predictable, repeatable separation process. The overlapped area formed by the overlapping end edges is tapered such that there is a point across the sheet width with the greatest overlap in the direction of the pulling force and a point across the sheet width with the least overlap in the direction of the pulling force. This configuration allows the area of maximum overlap to pull the next sheet through the dispensing aperture at the same time that the sheet separation process is starting to take place at the area of least overlap. The separation process begins at the point of least overlap and proceeds across the overlapping area along a "separation front" toward the point of greatest overlap. When the overlapping area is reduced to the extent that there is insufficient overlapping area to sustain the shear forces exerted, complete separation of the two sheets will occur. The area of overlap, length of the separation front, and amounts of overlap at the point of greatest overlap can all be tailored to provide desired separation characteristics for a particular aperture size, substrate, moistening agent, and moisture loading.
Patent DE-69411348-D1 (DE)
Inventor: SUTHERLAND ROBERT
IPC: B65D5/02
Filed: 1994-05-09
Granted: 1998-08-06
Abstract: A wrap-around carrier with end panel flaps that automatically close when the bottom panel flaps are set up for locking engagement. The end panel flaps are foldably connected to the side panels and to gusset panels which are also foldably connected to a bottom panel flap. Upon folding the gusset panels into engagement with the adjacent bottom panel flap, the end panel flaps are folded into closed position. The folded gusset panels are located between the bottoms of the packaged articles and the bottom panel, thereby locking the end panel flaps in closed position.
Patent DE-69412283-D1 (DE)
Inventor: ROBERTS THOMAS
IPC: C08F8/46
Filed: 1994-12-07
Granted: 1998-09-10
Abstract: A process for the preparation of a maleated polyethylene wax is disclosed. This process entails mixing in the melt phase polyethylene, maleic anhydride, free radical initiator and a chain transfer agent m-di-isopropylbenzene. This process can be a continuous process either in a stirred reactor or twin screw extruder. The resulting maleated polyethylene wax has a high acid number, essentially no objectionable odor, and a Gardner color number less than 3.
Patent DE-69413822-D1 (DE)
Inventor: SATAKE KUNIO
IPC: A61P37/08
Filed: 1994-07-05
Granted: 1998-11-12
Abstract: PCT No. PCT/JP94/01092 Sec. 371 Date Mar. 3, 1996 Sec. 102(e) Date Mar. 3, 1996 PCT Filed Jul. 5, 1994 PCT Pub. No. WO95/02595 PCT Pub. Date Jan. 26, 1995A compound of chemical formula (I) and its pharmaceutically acceptable salt:    <IMAGE>  (I)  wherein X and Y are each hydrogen, halogen, C1-C6alkyl, halosubstituted C1-C6alkyl, C1-C6alkoxy, C1-C6alkylthio, C1-C6alkylsulfinyl, C1-C6alkylsulfonyl, or tri(C1-C6alkyl)silyl; Ar1 and Ar2 are each independently aryl or heteroaryl, optionally substituted by halogen; A is -CO- or -(CH2)-; Z-A- is at the 2 or 3 position on the quinuclidine ring; and Z is -OH, C1-C6alkoxy, NR1R2 or the like. Representative compounds are (3S,4R,5S,6S)-5-[3,5-bis(trifluoromethyl)-benzyloxy]-N,N-dimethyl-6-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-carboxamide, and -3-carboxylic acid. These novel benzyloxyquinuclidines are active as substance P receptor antagonists and are thus useful for treating gastrointestinal disorders, central nervous system disorders, allergy, inflammatory diseases, asthma, pain, emesis, migraine, urinary incontinence, or angiogenesis in mammals, especially humans.
Patent DE-69426076-D1 (DE)
Inventor: HANNUM H
IPC: A61P25/00
Filed: 1994-05-18
Granted: 2000-11-09
Abstract: This invention provides mammalian Flt3 ligands and variants thereof, nucleic acids encoding the same, recombinant vectors and host cells comprising such nucleic acids, and antibodies or binding fragments thereof which specifically bind to the ligands or variants thereof, kits, and pharmaceutical compositions for modifying the biological activity of cells bearing Flt3 ligand receptors. Methods for making and using the foregoing materials are also provided by this invention. More particularly, a variant of the invention has Ala at alpha  alpha 72.
Patent DE-69505727-D1 (DE)
Inventor: DOWNEY ANGELA BRIDGET
IPC: B27K3/50
Filed: 1995-04-24
Granted: 1998-12-10
Abstract: Synergistic microbicidal compositions are disclosed, comprising 4,5-dichloro-2-n-octyl-3-isothiazolone and 2-methylthio-4-tert-butylamino-6-cyclopropylamino-s-triazine or N,N-dimethyl-N'-phenyl-(N'-fluorodichloromethylthio)sulfamide for more effective, and broader control of microorganisms in various systems