Patent SG-11201910053Y-A (SG)
Title: Trisubstituted pyrimidine compounds and compositions for the treatment of cancer, retinal disorders, and cardiomyopathies
Inventor: DE VIVO MARCO
IPC: C07D405/04
Filed: 2018-05-02
Abstract: WO 18/ 203 25 6 Al N (I) (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 November 2018 (08.11.2018) WIPO I PCT omit °nolo oimIE (10) International Publication Number WO 2018/203256 Al (51) International Patent Classification: CO7D 401/04 (2006.01) A61K 31/506 (2006.01) CO7D 401/14 (2006.01) A61P 35/00 (2006.01) C07D 405/04 (2006.01) (21) International Application Number: PCT/IB2018/053047 (22) International Filing Date: 02 May 2018 (02.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 102017000047189 02 May 2017 (02.05.2017) IT (71) Applicants: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA [IT/IT]; Via Morego, 30, 16163 Geno- va (IT). THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 12th Floor, 1111 Franklin Street, Oakland, California 94607-5200 (US). (72) Inventors: DE VIVO, Marco; Via Orlando 14/17, 16146 Genova (IT). GANESAN, Anand; 202 Sprague Hall, Irvine, California 92697-2400 (US). ORTEGA MARTINEZ, Jose Antonio; Via Pollen 3/2L, 16125 Gen- ova (IT). JAHID, Sohail; 250 Sprague Hall, Irvine, Cali- fornia 92697-2400 (US). (74) Agent: CASCIANO, Lidia et al.; Studio Torta S.p.A., Via Viotti, 9, 10121 Torino (IT). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE (54) Title: TRISUBSTITUTED PYRIMIDINE COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER, RETINAL DISORDERS, AND CARDIOMYOPATHIES (57) : The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a phar- maceutical composition comprising the compounds of Formula (I) and their us- es, in particular in the treatment of diseases or disorders associated to increased relative to physiological or desired RhoJ/Cdc42 levels of expression or function.