Patent NZ-333974-A (NZ)
Title: 1,4-diaryl-3-fluoro-2-butene (fluroolefin) compounds used against athtropod parasites
Inventor: WATSON DAVID WESLEY
IPC: A61K31/075
Filed: 1999-01-29
Abstract: A method of treatment for controlling, preventing and protecting non-human animals from infestation and infection by arthropod or helminth parasites which comprises administering or applying to the animals or their environment, a parasitically effective amount of a compound of the formula above, wherein: Ar is phenyl optionally substituted with any combination of from one to three halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups; 1- or 2-naphthyl optionally substituted with any combination of from one to three halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups; or a 5- or 6-membered heteroaromatic ring optionally substituted with any combination of from one to three halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups; R and R1 are each independently hydrogen, C1-C4alkyl, C1-C4haloalkyl, C3-C6cycloalkyl or C3-C6halocycloalkyl, or R and R1 taken together with the carbon atom to which they are attached form a C3-C6cycloalkyl ring optionally substituted with any combination of from one to three halogen or C1-C4alkyl groups, provided that when Z is F, R1 is hydrogen; Z is hydrogen or F; R2 is hydrogen, Cl, Br, cyano or OR3; R3 is hydrogen or C1-C4alkyl; and Ar1 is phenoxyphenyl optionally substituted with any combination of from one to six halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups; phenyl optionally substituted with any combination of from one to five halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups; biphenyl optionally substituted with any combination of from one to five halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups; henoxypyridyl optionally substituted with any combination of from one to five halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups; benzylpyridyl optionally substituted with any combination of from one to five halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups, benzylphenyl optionally substituted with any combination of from one to five halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups; benzoylphenyl optionally substituted with any combination of from one to five halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups; 1- or 2-naphthyl optionally substituted with any combination of from one to three halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups; or a 5- or 6-membered heteroaromatic ring optionally substituted with any combination of from one to three halogen, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy or C1-C4haloalkoxy groups; and the optical isomers thereof, and the (E)- and (Z)- isomers thereof. The use of the compound above in the manufacture of a medicament for controlling, preventing and protecting humans from infestation and infection by arthropod or helminth parasites. A composition for treating, controlling, preventing and protecting humans and animals from infestation and infection by arthropod or helminth parasites which comprises an environmentally or pharmaceutically acceptable carrier and a compound of the formula above, the composition being other than an agronomical composition.