baber/WOPTO huggingface dataset:
Patent EA-015925-B1 (EA)
Title: A method for producing polypeptides
Inventor: BOUBOS JOHANNES ANDIRES
IPC: C12N15/67
Filed: 2007-06-15
Abstract: The present invention relates to methods of optimization of a protein coding sequences for expression in a given host cell. The methods apply genetic algorithms to optimise single codon fitness and/or codon pair fitness sequences coding for a predetermined amino acid sequence. In the algorithm generation of new sequence variants and subsequent selection of fitter variants is reiterated until the variant coding sequences reach a minimum value for single codon fitness and/or codon pair fitness. The invention also relates to a computer comprising a processor and memory, the processor being arranged to read from and write into the memory, the memory comprising data and instructions arranged to provide the processor with the capacity to perform the genetic algorithms for optimisation of single codon fitness and/or codon pair fitness. The invention further relates to nucleic acids comprising a coding sequence for a predetermined amino acid sequence, the coding sequence being optimised with respect to single codon fitness and/or codon pair fitness for a given host in the methods of the invention, to host cells comprising such nucleic acids and to methods for producing polypeptides and other fermentation products in which these host cells are used.
Patent EA-018046-B1 (EA)
Title: Sulfonamide derivatives as bradykinin receptor antagonists, production thereof and pharmaceutical composition containing them
Inventor: BOZO EVA
IPC: A61P29/00
Filed: 2007-10-27
Abstract: The present invention relates to new sulfonamide derivatives of formula (I)wherein R-Rand Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to a process for producing these compounds, pharmacological compositions containing them.
Patent EA-018131-B1 (EA)
Title: A method of optically analysing a sample
Inventor: THOMSON ALASDAIR IAIN
IPC: G01N21/03
Filed: 2008-07-04
Abstract: A method of optically analysing a sample, which method comprises directing one or more frequencies of electromagnetic radiation (EMR) through a sample and onto a partially reflective surface (9) that allows EMR (6) directed thereon to be both reflected and transmitted, which reflected EMR (12) is directed back through the sample such that the pathlength through the sample is different for the transmitted EMR (10) and reflected EMR (12), which transmitted EMR and reflected EMR are both detected by one or more detectors (11, 15), characterised in that the optical absorbance of the sample at the one or more wavelengths of EMR is calculated from the difference between the transmitted EMR (10) and reflected EMR (12).
Patent EA-015741-B1 (EA)
Title: Alcohol beverage and method for production thereof
Inventor: DEREVYANKO NIKOLAJ NIKOLAEVICH
IPC: C12G3/06
Filed: 2010-03-09
Abstract: The invention relates to the alcoholic beverages production, in particular, an alcoholic beverage and a method of production thereof, and can be used for cost-effective mass production of the original mature alcoholic beverages. The alcoholic beverage comprises an aqueous-alcoholic solution, an aqueous infusion of the milled roasted acorns in concentration of 10 to 50 %, an aqueous infusion of the milled brier dried root in concentration of 10 to 50 % and an oak timber, at the following component percentage per 1 liter of the aqueous-alcoholic solution having concentration of 40 to 45 %, g: acorns infusion -10-30, brier root infusion - 10-30, oak timber - 50-150. In the production of the alcoholic beverage according to the claimed method under certain conditions the aqueous infusion of the milled roasted acorns and the aqueous infusion of the milled brier dried root are separately obtained, and are added them into the aqueous-alcoholic solution having concentration of 40 to 45 % in a certain quantity, the obtained immature alcoholic beverage is poured into a translucent container, wherein the oak timber is preliminary placed, with the subsequent hermetical sealing of the container, and the alcoholic beverage is matured. The claimed alcoholic beverage and method at the minimum possible quantity of the various ingredients and the minimum possible processing thereof ensure the receipt of a high-quality alcoholic beverage of a “cognac” type having an unlimited period of storage.2
Patent EA-018931-B1 (EA)
Title: Disubstituted phthalazine hedgehog pathway antagonists
Inventor: BASTIAN JOLIE ANNE
IPC: A61K31/502
Filed: 2009-10-22
Abstract: The present invention provides novel 1,4-disubstituted phthalazine hedgehog pathway antagonists useful in the treatment of cancer.
Patent EA-025276-B1 (EA)
Title: (2S,3S)-3-((2-(5-FLUORO-1H-PYRROLO[2,3-b]PYRIDIN-3-YL)-5-FLUOROPYRIMIDIN-4-YL)AMINO)BICYCLO[2.2.2]OCTANE-2-CARBOXYLIC ACID, PHARMACEUTICAL COMPOSITION COMPRISING SAME AND METHODS OF USING SAID COMPOUND
Inventor: CHARIFSON PAUL
IPC: A61P31/16
Filed: 2010-06-17
Abstract: The invention relates to a new compound, particularly to (2S,3S)-3-((2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl)amino)bicyclo[2.2.2]octane-2-carboxylic acid, having the property of inhibiting the replication of influenza A virus in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient. The invention further relates to a pharmaceutical composition comprising an effective amount of such a compound or pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, adjuvant or vehicle, and is provided for reducing the amount of influenza A viruses. Also disclosed is a method of reducing the amount of influenza A viruses in an in vitro biological sample, comprising administering to said biological sample an effective amount of said compound.
Patent EA-024256-B1 (EA)
Title: Process for manufacturing dihydropteridinones and intermediates thereof
Inventor: SCHNAUBELT JUERGEN
IPC: C07D475/00
Filed: 2011-10-11
Abstract: The present invention relates to an improved process for manufacturing dihydropteridinones of general formula (11) as well as necessary intermediates thereof, wherein the groups R, R, R, R, and Rhave the meanings given in the claims and specification.
Patent EA-024543-B1 (EA)
Title: Fireproof glazing
Inventor: HERREMANS GUILLAUME
IPC: E06B5/16
Filed: 2011-08-31
Abstract: The invention relates to fireproof glazing comprising at least one intumescent layer of hydrated alkaline silicate having a thickness of no less than 2.5 mm and containing water and optionally compounds partially substituting the water, namely either glycerin or ethylene glycol, said compounds and water combined representing between 25 and 45 wt.% of the layer, with a molar ratio SiO/MO of between 2.5 and 6. The viscosity of the intumescent layer prevents the layer from creeping over time.
Patent EA-036943-B1 (EA)
Title: Soft hand-off and routing data in a virtualized distributed antenna system
Inventor: MEERKERK DARYL
IPC: G01S3/02
Filed: 2012-11-06
Abstract: In some embodiments of the invention, a system for managing resource use in a distributed antenna system is provided. The system may include a plurality of digital remote units (DRUs) configured to send and receive wireless radio signals; a plurality of sectors, each configured to send and receive wireless radio signals; and a plurality of inter-connected digital access units (DAUs), each configured to communicate with at least one of the DRUs via optical signals, and each being coupled to at least one of the sectors.
Patent EA-030386-B1 (EA)
Title: Microcontroller for environment pollution control system for an internal combustion engine
Inventor: MONROS SERGE V
IPC: B60T7/12
Filed: 2014-01-15
Abstract: An environment pollution control system for an internal combustion engine includes a microcontroller, a power supply, a plurality of sensors configured to measure operating parameters of the engine, and a PCV valve responsive to control signals from the microcontroller and configured to regulate a flow rate of blow-by gasses in the engine. The microcontroller includes programmable flash memory connected to a control processor, a power supply input, a sensor input configured to receive data from engine sensors, and a signal output configured to transmit a signal from the control processor so as to control operation of a PCV valve regulating a flow rate of blow-by gasses in the engine.
Patent EA-026328-B1 (EA)
Title: (THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HTANTAGONISTS
Inventor: GALLAGHER PETER THADDEUS
IPC: C07D498/04
Filed: 2014-01-08
Abstract: A dual H1 inverse agonist/5-HTreceptor antagonist of the formulaits uses, and methods for its preparation are described.
Patent EA-029566-B1 (EA)
Title: Device for haemodiafiltration
Inventor: TSCHULENA ULRICH
IPC: A61M1/36
Filed: 2013-12-19
Abstract: The invention relates to a device for haemodiafiltration comprising an extracorporeal circulation system (10) for receiving blood to be cleaned and comprising a haemodialyser and/or haemofilter (20) which is connected to the blood circulation system (10), said blood circulation system (10) having at least one respective supply line (12, 14) located upstream and downstream of the haemodialyser and/or haemofilter (20), for supplying a substitution fluid, the invention is characterised in that the device comprises measuring devices for recording the transmembrane pressure and/or haematocrit (HKT) and/or blood density, the measuring devices being connected to a control unit (100) for controlling one or more of the transmembrane pressure, and/or haematocrit (HKT) and/or blood density and said control unit (100) being constructed in such a way that the control is carried out with the aid of at least one of the infusion speeds (Qpre, Qpost) of the substitution fluid (13, 15), and in that the blood to be cleaned is exposed to a high-frequency electromagnetic field and/or an electric DC field (70) before and/or during the contact with the dialyser and/or haemofilter (20).
Patent EA-031473-B1 (EA)
Title: Method for treating a tumour disease and method for selectively inhibiting tumour cell growth using a quinoxaline-1,4-dioxide derivative
Inventor: SHCHEKOTIKHIN ANDREY EGOROVICH
IPC: A61P35/00
Filed: 2014-04-28
Abstract: The present invention relates to the fields of pharmacology and oncology, and more particularly to the medical use of 6,7-difluoro-3-phenyl-2-cyanoquinoxaline-1,4-dioxide of formula (I) for inhibiting the growth of tumour cells or treating tumour diseases.
Patent EA-031531-B1 (EA)
Title: Method and device for separating hydrocarbons and contaminants with a heating mechanism to destabilize and/or prevent adhesion of solids
Inventor: VALENCIA JAIME A
IPC: F25J3/02
Filed: 2014-10-17
Abstract: The present invention provides a method for separating a feed stream in a distillation tower which includes separating a feed stream in a stripper section into an enriched contaminant bottom liquid stream and a freezing zone vapor stream; contacting the freezing zone vapor stream in the controlled freeze zone section with a freezing zone liquid stream at a temperature and pressure at which a solid and a hydrocarbon-enriched vapor stream form; directly applying heat to a controlled freeze zone wall of the controlled freeze zone section with a heating mechanism coupled to at least one of a controlled freeze zone internal surface of the controlled freeze zone wall and a controlled freeze zone external surface of the controlled freeze zone wall; and at least one of destabilizing and preventing adhesion of the solid to the controlled freeze zone wall with the heating mechanism.
Patent EA-030575-B1 (EA)
Title: Gypsum plaster-based material containing an edta metal complex
Inventor: CHUDA KATARZYNA
IPC: C04B28/14
Filed: 2014-12-23
Abstract: The present invention relates to a gypsum plaster-based material, in particular a gypsum plasterboard intended for the interior decoration of dwellings, containing an EDTA metal complex. The present invention relates to the use of said material in order to reduce the amount of volatile organic compounds in the atmosphere inside dwellings, offices or public buildings.
Patent EA-037993-B1 (EA)
Title: Htt repressors and uses thereof
Inventor: FROELICH STEVEN
IPC: C12Q1/68
Filed: 2016-09-23
Abstract: Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.
Patent EA-037525-B1 (EA)
Title: Method and apparatus for mobile fueling
Inventor: HACOHEN YUVAL HAI
IPC: G07F17/00
Filed: 2017-07-17
Abstract: In accordance with an embodiment of the invention, a system and method are provided to enable mobile fuel management, the system including a mobile communications device with an integrated Bluetooth capability, the device running an application that includes a file with instructions to execute commands to enable mobile fuel management; a fuel dispenser with an integrated Bluetooth device; and a fuel station computer system communicatively connected to a computing cloud and associated with a dispenser database, the computer system running code to execute commands to enable mobile fuel management; wherein the fuel dispenser executes fuel dispensing only after a matching between the mobile communications device and the fuel dispenser.
Patent EA-038539-B1 (EA)
Title: Single-loop nuclear power plant with pressurized coolant
Inventor: KOROVKIN SERGEY VIKTOROVICH
Filed: 2017-12-29
Abstract: In a single-loop nuclear power plant with a pressurized coolant, comprising a power generating unit and a throttling device having an impeller, which are interconnected by an outlet pipe and a feed pipe, and a steam turbine connected by pipes to the throttling device and to a condenser which is also connected to the throttling steam generator, the throttling device is configured in the form of a throttling steam generator which is vertically divided into a vapour zone, a high pressure zone, and a low pressure zone by means of horizontal sealed partitions, the vapour zone is situated above the high pressure zone, which is situated above the low pressure zone, the high pressure zone is connected to the inlet of the feed pipe and is connected to the low pressure zone by throttling nozzles provided in the partition between said zones, about the periphery of said partition and at an angle to the vertical, and the low pressure zone is connected to the vapour zone by a vertical pipe which passes through the centres of the horizontal sealed partitions and the high pressure zone, wherein the single-loop nuclear power plant is additionally provided with an electric motor configured for rotation of the impeller. The single-loop nuclear power plant with a pressurized coolant and a throttling steam generator allows highly efficient use of nuclear fuel, and also provides reliable and safe operation in all regimes, and is applicable in the nuclear power industry.
Patent ES-2177382-B1 (ES)
Title: Triangulo para señalizacion de emergencia.
Inventor: ZUGAZA ALCELAY YOLANDA
IPC: B60Q7/00
Filed: 2000-02-17
Granted: 2004-08-16
Abstract: Triángulo para señalización de emergencia, plegable, con dos lados articulados fijamente a los extremos de un tercero de base; portando los tres lados sus distintivos reflectantes y pestañas internas homologadas. En relación con los extremos del lado/base se disponen sendos cabezales, portantes de sendas levas que giran respecto al cabezal entre dos posiciones extremas delimitadas por topes; yendo asociada cada una de dichas levas a un soporte intermedio que gira respecto a ella entre dos posiciones extremas delimitadas por topes y monta a su vez, a un brazo/pata con posibilidad de girar respecto a él entre dos posiciones extremas delimitadas por topes. El ángulo barrido por el brazo/pata en su giro respecto al soporte intermedio, está contenido en un plano ortogonal a los planos que contienen el ángulo barrido por la leva y por el soporte intermedio en su giro; de modo que, por sencilla actuación manual, se logra desplegar cuatro brazos/pata en simetría dos a dos, espacialmente angulados tanto entre sí como respecto a los lados del triángulo o plegados adosados dos a dos sobre las caras frontal y posterior del lado/base. De aplicación como accesorios de vehículos.
Patent ES-2173798-B1 (ES)
Title: Dispositivo de fijacion y regulacion vertical para guias extensibles de cajones de muebles.
Inventor: RIOJA CALVO MIGUEL ANGEL
IPC: A47B88/04
Filed: 2000-07-06
Granted: 2003-10-01
Abstract: Dispositivo de fijación y regulación vertical para guías extensibles de cajones de muebles, consistente en el carril fijo (1) unido al mueble (3) mediante un primer pivote (6) encajado a presión y un segundo pivote (7) que encaja en un agujero ciego (3a) del mueble (3) dotado de cabeza excéntrica (8) y cuello excéntrico (9) con ajuste rotatorio en un alojamiento (10) a través del carril fijo (1); el carril móvil (2) tiene un agujero (13) con ajuste deslizante; en una posición abierta del cajón (4), el orificio axial (33) es susceptible de quedar alineado con una huella frontal (16) que está grabada en la cabeza excéntrica (8) del segundo pivote (7), recíproca de la punta de la herramienta rotatoria (15); el casquillo liso (32) está unido al ligamento flexible (34) incorporando una espiga arponada (35) aprisionada en un encaje pasante (36) del lateral del cajón (4), la espiga (35) tiene en su punta un saliente ganchudo (37) cuya boca está enfrentada longitudinalmente al borde trasero del alma del carril móvil (2) con amplitud ajustada por exceso al grosor de esta alma.
Patent ES-2197740-B1 (ES)
Title: Piscifactoria para el engorde de peces y crustaceos.
Inventor: FERNANDEZ DE SOUSA FARO MANUEL
IPC: A01K61/60
Filed: 2001-02-21
Granted: 2005-04-01
Abstract: Piscifactoría para el engorde del peces y crustáceos, que comprende una jaula (1), que presenta una estructura (2), constituida por perfiles soldados o atornillados, sobre los que se fija una malla (3), componiendo en conjunto un recinto cerrado, dotado de patas de apoyo (4) que se apoya en el fondo marino manteniendo la jaula sumergida firmemente anclada en el fondo del mar por gravedad o con ayuda de un lastre.
Patent ES-2217938-B1 (ES)
Title: Accesorio para eliminar determinadas contrasalidas en los utillajes de fundicion.
Inventor: CAETANO BLASCO ABILIO
IPC: B22C9/02
Filed: 2002-09-18
Granted: 2006-02-16
Abstract: Accesorios para eliminar determinadas contrasalidas en los utillajes de fundición. El modelo (1) dispone de una o más perforaciones (2) con guía (3), antagonistas de, al menos, uno o unos émbolos (4) de construcción simple o de múltiples piezas, correspondientes a un o unos cilindros (5), hidráulicos o neumáticos, incorporados al molde (6) y en el interior del modelo (1) de modo que, oportunamente, dejan en la arena (7) prensada uno o varios orificios (8) que, tras ser realizada la colada, genera un saliente en la pieza de fundición.
Patent ES-2263365-B1 (ES)
Title: "dispositivo para la union de vigas de perfil normal".
Inventor: GABARROS ROVIRA SALVADOR
IPC: F16B7/04
Filed: 2005-01-07
Granted: 2007-11-16
Abstract: Dispositivo para la unión de vigas de perfil normal. Dispositivo para la unión de dos vigas de perfil normal constituido por dos partes sensiblemente iguales, giradas una respecto de la otra y unidas inseparablemente entre sí, estando cada parte provista de dos alas laterales paralelas, respectivamente, que se extienden perpendicularmente a una correspondiente placa plana, estando una de las alas de cada parte provista de una extensión paralela a su placa plana determinando éstas sendos entrantes adaptados para recibir con ajuste las alas de respectivas vigas, a la vez que una de las caras de las almas de las mismas vigas se apoya contra las caras de las extensiones paralelas enfrentadas a dichas almas, estando además las alas contrarias de cada parte provistas de unos medios de sujeción para ejercer presión contra las otras caras de las almas de las vigas apoyadas en las extensiones.
Patent ES-2265759-B1 (ES)
Title: Colchon de firmeza regulable y soporte lateral mejorado con altas propiedades de distribucion de presiones.
Inventor: SOLANS SOLANS ALFONSO
IPC: A47C27/16
Filed: 2005-03-15
Granted: 2007-12-16
Abstract: Colchón de firmeza regulable y soporte lateral mejorado con altas propiedades de distribución de presiones. Comprende una base de soporte (2), un contorno de refuerzo (5) que se extiende a lo largo de los dos lados mayores del colchón (1) y de uno de sus lados menores y que está interrumpido en el otro lado menor del colchón, un núcleo hinchable (3) dispuesto sobre dicha base de soporte (2), recubierto por una capa de tejido y estanco al aire, con una válvula (4) de paso de aire, asomando dicho núcleo por el lado del colchón en el que está interrumpido dicho contorno de refuerzo (5), una plancha (6) de distribución de presiones dispuesta sobre dicho núcleo hinchable (3), y una funda de tejido (7) que recubre todo el colchón (1), salvo la boquilla de la válvula (4) que asoma al exterior.
Patent ES-2281295-B1 (ES)
Title: Procedimiento para el tratamiento del lodo procedente del proceso de pulido y corte de piedra.
Inventor: MARTINEZ CAMUS JOSE LEANDRO
IPC: C02F11/127
Filed: 2006-03-14
Granted: 2008-09-01
Abstract: Procedimiento para el tratamiento del lodo procedente del proceso de pulido y corte de piedra. Comprende el secado térmico de dicho lodo empleando para ello energía térmica procedente de un equipo de cogeneración, y se caracteriza por el hecho de que el vapor procedente del secado de dicho lodo es condensado empleando para ello también la energía térmica procedente de dicho equipo de cogeneración. Posibilita la valorización de los lodos procedentes del proceso de pulido y corte de piedra, todo ello con un rendimiento energético muy alto y con un impacto ambiental nulo.
Patent ES-2334874-B1 (ES)
Title: Aparato y procedimiento de control de aproximacion del rodillo tensor al rodillo aplicador de cola de una doble encoladora de una maquina de fabricacion de carton ondulado.
Inventor: SAHAGUN CASANOVA FRANCISCO JOSE
IPC: B05C1/08
Filed: 2008-03-05
Granted: 2010-10-25
Abstract: Aparato y procedimiento de control de
aproximación del rodillo tensor al  rodillo aplicador de cola de una
doble encoladora de una máquina de fabricación  de cartón
ondulado. 
     Un conjunto (1) formado por una lámina interior
(2) unida a una lámina  ondulada (3) discurre apoyando la lámina
interior sobre el rodillo tensar  (14) y la lámina ondulada (3)
próxima al rodillo aplicador de cola (15)  para aplicarle la cola y
efectuar el posterior pegado de una lámina exterior;  caracterizado
porque comprende medios de medida de espesor del conjunto  (1),
medios de medida de separación entre el rodillo tensar (14) y el
rodillo  aplicador de cola (15) y medios de regulación de la presión
ejercida por  el rodillo tensar (14) sobre la lámina interior (2) en
función de la medida  del espesor y de la medida de separación, para
realizar la perfecta aplicación  de cola con independencia del
espesor del conjunto (1).
Patent ES-2345755-B1 (ES)
Title: Soporte publicitario toallero en pistas de tenis.
Inventor: BARRERO LOPEZ JOSE ALBERTO
IPC: A47K10/04
Filed: 2008-10-30
Granted: 2011-08-08
Abstract: Soporte publicitario toallero en pistas de
tenis. 
     Constituido en forma de copa, constando dicho
soporte de una base de sustentación al suelo de donde parte un
vástago de poco diámetro de espesor y que sostiene un cuerpo cóncavo
de forma oval. Su colocación es en vertical y en aquellos espacios
de las pistas de tenis en los que se sitúan los recogepelotas
encargados de suministrar la toalla al jugador que la usa para
secarse el sudor. La publicidad se inserta en los laterales de éste
aunque toda la pieza tenga el color corporativo. El soporte termina
en su parte superior en un cuerpo cóncavo tal que permite alojar una
bandeja o cuenco y, sobre ésta, depositar la toalla.