Patent SG-11201900181R-A (SG)
Title: Insulin analogs
Inventor: MENTING JOHN GERBRANDT TASMAN
IPC: C07K14/62
Filed: 2017-07-21
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD HIM 0 11101 HOE 3E1 0 0111111 0101110110M OE 11110 ill 011 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\"1 WO 2018/014091 Al 25 January 2018 (25.01.2018) WIP0 I PCT (51) International Patent Classification: (84) Designated States (unless otherwise indicated, for every C07K 14/62 (2006.01) A61K 38/28 (2006.01) kind of regional protection available): ARIPO (BW, GH, (21) International Application Number: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, PCT/AU2017/050758 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (22) International Filing Date: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 21 July 2017 (21.07.2017) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (25) Filing Language: English KM, ML, MR, NE, SN, TD, TG). (26) Publication Language: English Published: (30) Priority Data: — with international search report (Art. 21(3)) 2016902883 22 July 2016 (22.07.2016) AU — with sequence listing part of description (Rule 5.2(a)) 62/483,118 07 April 2017 (07.04.2017) US (71) Applicants: UNIVERSITY OF UTAH RESEARCH FOUNDATION [US/US]; 615 Arapreen Drive, Suite 310, Salt Lake City, Utah 84108 (US). THE WAL- TER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH [AU/AU]; 1G Royal Parade, Parkville, Vic- toria 3052 (AU). LA TROBE UNIVERSITY [AU/AU]; Innovation and Commercialisation, 2 Research Avenue, Technology Enterprise Centre, Bundoora, Victoria 3086 (AU). Inventors: MENTING, John Gerbrandt Tasman; 1 (72) Kimberley Way, Bulleen, Victoria 3105 (AU). SMITH, Brian; 6 Kathryn Court, Bundoora, Victoria 3429 (AU). CHOU, Danny Hung-Chieh; 15 North Medical Dri- ve East, Salt Lake City, Utah 84112 (US). SAFAVI- HEMAMI, Helena; 320 N. Margarethe Lane, Salt Lake City, Utah 84108 (US). LAWRENCE, Michael Colin; 154 Woods Street, Newport, Victoria 3015 (AU). BAL- DOMERO, Olivera M.; 1370 E. Bryan Ave, Salt Lake City, Utah 84105 (US). Agent: FB RICE; Level 14, 90 Collins St, Melbourne, Vic- toria 3000 (AU). (74) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (81) 1-1 Il C:r © 7r ,-1 (54) Title: INSULIN ANALOGS 0 ---- (57) : The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present GC invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related 0 structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention N also relates to therapeutic and prophylactic methods using insulin analogs. C