baber/WOPTO huggingface dataset:
Patent CA-2817011-A1 (CA)
Inventor: DO HUNG
IPC: C12N9/24
Filed: 2011-11-08
Abstract: Described herein are variant, recombinant ß-glucocerebrosidase proteins characterized as having increased stability relative to recombinant wild-type ß- glucocerebrosidase. Also provided herein are variant, recombinant ß-glucocerebrosidase proteins characterized as retaining more catalytic activity relative to recombinant wild- type ß-glucocerebrosidase. Further described herein are variant, recombinant ß- glucocerebrosidase proteins that can have amino acid variations at one or more of the following positions: 316, 317, 321 and 145. Methods of making the variant, recombinant ß-glucocerebrosidase proteins are also described as well as methods of treating patients having lysosomal storage diseases.
Patent CA-2817455-A1 (CA)
Title: Detection of a polypeptide dimer by a bivalent binding agent
Inventor: GERG MICHAEL
IPC: C07K16/46
Filed: 2011-12-21
Abstract: The present invention relates to a bivalent binding agent capable of binding a polypeptide dimer the binding agent consisting of two monovalent binders that are linked to each other via a linker, wherein the first monovalent binder binds to an epitope of a first target polypeptide comprised in said dimer, wherein the second monovalent binder binds to an epitope of a second target polypeptide comprised in said dimer, wherein each monovalent binder has a Kdiss in the range of 5x10-3/sec to 10-4/sec, and wherein the bivalent binding agent has a Kdiss of 3x10-5/sec or less. A method of making such bivalent binding agent and the use of such bivalent agent in histological staining procedures are also disclosed.
Patent CA-2817751-A1 (CA)
Inventor: COLJEE VINCENT W
IPC: C12N15/10
Filed: 2011-11-16
Abstract: Methods for producing recombinant cell populations are disclosed. The disclosed methods may be used to produce therapeutic polyclonal proteins.
Patent CA-2818734-A1 (CA)
Inventor: WHITELY JEFFREY THOMAS
IPC: B31B50/64
Filed: 2013-06-18
Abstract: Plastic sheet can be heat-sealed to form a water-tight envelope having an open top. A water-tight frangible container can be loaded into the envelope through the open top. The water-tight frangible container can contain a predetermined amount of water. A predetermined amount of urea can be loaded into the envelope through the open top. Separate from the loading of the urea, a predetermined amount of ammonium chloride can be loaded into the envelope through the open top. The relative proportions of the predetermined amount of urea, the predetermined amount of ammonium chloride, and the predetermined amount of water can be selected to provide a target cooling effect to a portion of a body to which cooling is to be applied. The open top of the envelope can be heat-sealed to form a water-tight outer pack.
Patent CA-2818845-A1 (CA)
Title: Herbicidal composition comprising flazasulfuron and nicosulfuron
Inventor: KIKUGAWA HIROSHI
IPC: A01P13/02
Filed: 2011-11-24
Abstract: At present, various herbicidal compositions have been developed and used, but they are not necessarily sufficient to control undesired plants such as weeds to be controlled, and a highly active herbicidal composition is desired. A herbicidal composition comprising 1-(4,6-dimethoxypyrimidin-2-yl)-3- (3-trifluoromethyl-2-pyridylsulfonyl)urea (flazasulfuron) or its salt and 2-(4,6- dimethoxypyrimidin-2-ylcarbamoylsulfamoyl)-N,N-dimethylnicotinamide (nicosulfuron) or its salt, and a method for controlling undesired plants using it.
Patent CA-2820197-A1 (CA)
Title: Composition et procede pour aromatiser des compositions de soin buccal contenant une source de dioxyde de chlore
Inventor: RATCLIFF JAMES L
IPC: A61K8/86
Filed: 2011-06-09
Abstract: L'invention concerne une composition de soin buccal aromatisée et son procédé de fabrication pour empêcher et/ou traiter des maladies bactériennes, fongiques ou inflammatoires et des états de la cavité buccale. Cette composition peut être sous la forme d'un rinçage, d'une pulvérisation ou similaires, et exempte de glycérine et exempte d'huile de ricin et de dérivés d'huile de ricin, incorpore une source de dioxyde de chlore, un tampon phosphate, un système aromatisant contenant un ester de sorbitan polyoxyéthyléné (émulsifiant/agent de suspension) et un agent aromatisant, un édulcorant et de l'eau. Avec l'addition d'une source d'ion fluorure, la composition peut être utilisée comme agent anti-caries.
Patent CA-2821342-A1 (CA)
Inventor: MURRAY GUY
IPC: A63B21/072
Filed: 2013-07-17
Abstract: A compressible barbell adapter is disclosed, which consists of a compression- retraction member fastened to a hollow shaft for use on a bar. The compression and retraction movement of the compression-retraction member is generally achieved by means of a pinion and a rack system, and can be utilized in conjunction with dampening means. Slidable handles are also connected to the compression-retraction member, and serve to slide along the axis of the hollow shaft, and thus along the bar. The compressible barbell adapter is meant to be fastened onto existing bars or barbells such that additional exertion is focused on the pectoral, deltoid and back muscles during various exercises.
Patent CA-2825053-A1 (CA)
Inventor: SUPLIE PASCAL
IPC: A61K9/00
Filed: 2012-02-03
Abstract: The present invention relates to a granule including a solid core on which an active principle supported, said active principle being selected from among gamma-hydroxybutyric acid or one of the pharmaceutically acceptable salts thereof, said granule further including one or more compounds which are supported on said solid core and which are capable of releasing gas, and one or more diluents, said granule being characterized in that it is coated with a membrane and in that the solid core is 15 to 50 wt % with respect to the total weight of the granule.
Patent CA-2825625-A1 (CA)
Title: Process for improving the energy density of feedstocks using formate salts
Inventor: WHEELER MARSHALL CLAYTON
IPC: F25J1/00
Filed: 2011-12-20
Abstract: Methods of forming liquid hydrocarbons through thermal deoxygenation of cellulosic compounds are disclosed. Aspects cover methods including the steps of mixing a levulinic acid salt-containing feedstock with a formic acid salt, exposing the mixture to a high temperature condition to form hydrocarbon vapor, and condensing the hydrocarbon vapor to form liquid hydrocarbons, where both the formic acid salt and the levulinic acid salt-containing feedstock decompose at the high temperature condition and wherein one or more of the mixing, exposing, and condensing steps is carried out a pressure between about vacuum and about 10 bar. Other methods and parameters for generating energy dense liquid hydrocarbons are also disclosed and claimed.
Patent CA-2826877-A1 (CA)
Inventor: MELNYK OLEG
IPC: C07K1/00
Filed: 2012-02-15
Abstract: Procédé de préparation d'un assemblage peptidique de n fragments et de n-1 acides aminés portant une fonction thiol, représenté par la formule (I) : A1-C1-A2-A3-... -Ci-1-Ai-...-Cn-1-An dans laquelle A1, A2, A3... Ai.., An sont des fragments peptidiques, C1, C2, C3... Ci-1...Cn-1 sont des restes d'acides aminés portant une fonction thiol, n est compris entre 3 et 50, et i est 2 à n, dans lequel on prépare un peptide-thioester de formule : A1SR (I I) dans laquelle A1 est un fragment peptidique et SR est le reste d'un thioester alkylé, R étant alkyle éventuellement substitué, à partir d'un bis(2-sulfanyléthyl)amino peptide : A1-SEAoff dans laquelle SEAoff est groupement bis(2-sulfanyléthyl)amino cyclique, par action d'un thiol R-SH, en présence d'un réducteur de disulfures cycliques, suivie de la condensation sur un fragment peptidique de structure : H-C1(SR')-A2-SEAoff (III) dans laquelle (SR') représente un reste disulfure sur le thiol de l'amino-acide C1, en présence d'un thiol aromatique ArSH, puis transforme le nouveau peptide obtenu, de structure :A1-C1-A2- SEAoff (IV), en un peptide-thioester de formule : A1-C1-A2-SR (II'), par action d'un thiol R-SH, en présence d'un agent réducteur de disulfures cycliques, et condense sur un fragment peptidique de structure H-C2(SR')-A3-SEAoff (??I') en présence d'un thiol aromatique ArSH, pour donner un fragment peptidique, de structure A1-C1-A2-C2-A3-SEAoff (IV') et réitère ces 2 opérations jusqu'à n-2 fois, pour obtenir un fragment peptidique de structure A1-C1-A2-C2-A3-... -Ci-1-Ai-....-Cn-2-An-1-SEAoff (IVm), puis met en uvre une réaction de ligation native de ce fragment peptidique (IVm) obtenu, avec un peptide de formule : H-Cn-1-An (Vn) par réduction en présence d'un agent réducteur de disulfures cycliques, pour donner l'assemblage peptidique multiple de formule générale (I).
Patent CA-2828547-A1 (CA)
Inventor: KOJIMA KATSUMI
IPC: C21D8/02
Filed: 2012-03-15
Abstract: Provided is a steel sheet for an aerosol can bottom having high pressure resistance and excellent bendability, characterized in having a component composition of, by mass%, 0.02 to 0.10% of C, 0.01 to 0.5% of Si, 0.001 to 0.100% of P, 0.001 to 0.020% of S, 0.007 to 0.025% of N, and 0.01 to {-4.2 x N (%) + 0.11}% of Al, where when Mnf = Mn - 1.71 x S (provided that the amount of Mn and the amount of S in the formula is the Mn content (mass%) and S content (mass%) of the steel), Mnf is 0.10% greater but less than 0.30% and the balance is Fe and inevitable impurities; the sheet thickness is 0.35 (mm) or less; the product of the lower yield strength (N/mm2) of the steel sheet and the sheet thickness (mm) is 160 (N/mm) or less; and after 10% tensile predistortion, the product of the upper yield strength (N/mm2) when room-temperature aging has been performed for 10 days at 25ºC and the square of the sheet thickness (mm) is 52.0 (N) or greater.
Patent CA-2829065-A1 (CA)
Inventor: EDWARDS PAUL
IPC: B01D53/02
Filed: 2013-09-27
Abstract: The invention relates to an on-site medical gas production plant (100) comprising a unit (50) for purifying gas, such as air, a first compartment (A) for storing purified gas, and a main gas line (10) fluidically connecting the gas purification unit (50) to the said first storage compartment (A). It furthermore comprises a three-way actuated valve (VA) arranged on the main gas line (10) upstream of the first storage compartment (A), and furthermore connected to the atmosphere (at 12) via a vent line (11), as well as an operating device (4) which controls at least the three-way actuated valve (VA), and at least a first gas analysis device (D1) of which a first measurement line (29) is fluidically connected (at 28) to the main line (10), upstream of the three-way actuated valve (VA), and which is electrically connected to the said operating device (4).
Patent CA-2829835-A1 (CA)
Inventor: GOLZ STEFAN
IPC: G01N33/68
Filed: 2012-03-05
Abstract: The present invention is directed to the identification of modulators for SLC22A7 transporter and therapeutic uses thereof. Hence, in one embodiment the present invention relates to a method for identifying and/or obtaining a compound capable of modulating glutamate transport, comprising contacting a test compound with a system for measuring those transport activity, which system comprises an SLC22A7 polypeptide or a functional fragment thereof, and a substrate for measuring glutamate transport by the system; and detecting an altered level of the those transport activity of the SLC22A7 polypeptide or functional fragment in the presence of the test compound compared to the described transport activity in the absence of the test compound and/or presence of a control.
Patent CA-2831825-A1 (CA)
Inventor: SEO CHANG MIN
IPC: B01D69/08
Filed: 2012-04-25
Abstract: A hollow fiber membrane is formed by embedding a braid having a spiral open weave of monofilaments only, to avoid a "whiskering" problem common in prior art multifilament braid-supported tubular membranes. The open weave is characterized by contiguous, circumferential, rhomboid-shaped areas of polymer film separated by monofilaments. When the braid is supported on a plasticized PVA  cable it can be infiltrated with membrane polymer which, when coagulated embeds the braid positioning it around the lumen. The spiral weave, free of any circumferentially constricting monofilament, when embedded in film, allows the membrane to be biaxially distensible. In other words, the membrane has "give"  not only in the axial or longitudinal direction but also in the radial direction.  "Give" in the radial direction permits soiled membranes to be backwashed under higher pressure than in a comparable braid which is not radially distensible.
Patent CA-2833194-A1 (CA)
Inventor: JONSSON LEIF
IPC: C12P7/10
Filed: 2012-06-11
Abstract: The present invention relates to a method of enzymatic hydrolysis of a lignocellulosic material, comprising the steps of: a) pretreating the lignocellulosic material to obtain a slurry having a pH of less than 6; b) adding NaOH, Ca(OH)2 and/or CaO to the slurry to increase its pH to at least 8, said addition being carried out at a slurry temperature of at least 60 °C; c) reducing the pH of the slurry to below 7; and optionally cooling the slurry from step b) to a temperature below 60 °C; and d) adding hydrolytic enzymes to the slurry from c) and allowing the slurry to hydrolyze wherein no washing of the slurry is performed prior to step d)
Patent CA-2836075-A1 (CA)
Title: Method for mitigating the formation of by-products during the production of haloalkane compounds
Inventor: CLOSE JOSHUA
IPC: B01J23/745
Filed: 2012-05-30
Abstract: Disclosed is a process for the manufacture of haloalkane compounds, and more particularly, an improved process for the manufacture of the compound 1,1,1,3,3-penta-chloropropane (HCC-240fa), which mitigates the formation of by-products from vinyl chloride (CH2=CHCl). The present invention is also useful in the manufacture of other haloalkane compounds such as HCC-250 and HCC-360. One embodiment of the invention comprises a method for mitigating 1,1,3,3,5,5-hexachloropentane and 1,1,1,3,5,5-hexachloropentane formation in the HCC-240fa manufacturing process, in which FeCl3, is introduced to a reactor only after the start-up phase has ended and a continuous operation has started. In a preferred embodiment, "pre-chelated" FeCl3, which is concentrated in a catalyst recovery column, is introduced to reactor after the continuous operation has started.
Patent CA-2838496-A1 (CA)
Inventor: PENTON ROL GISELLE
IPC: A61K38/08
Filed: 2012-06-29
Abstract: The invention relates to peptides comprising phycocyanobilin (PCB), as well as to the use of said peptides and PCB in medicine owing to the neuroprotective and/or neurogenerative effects thereof that have been identified. In addition, the invention relates to pharmaceutical combinations of said peptides and PCB with proteins or other peptides which, owing to the synergistic effect thereof, are suitable for use in the treatment of diseases of the central nervous system involving neurodegenerative and ischemic damage.
Patent CA-2849060-A1 (CA)
Title: Plants having increased tolerance to herbicides
Inventor: HUTZLER JOHANNES
IPC: A01H1/00
Filed: 2012-10-30
Abstract: A method for controlling undesired vegetation at a plant cultivation site is provided, which comprises the steps of providing, at said site, a plant comprising at least a nucleotide sequence encoding a wild-type hydroxyphenyl pyruvate dioxygenase or a mutated hydroxyphenyl pyruvate dioxygenase (mut-HPPD) which is resistant or tolerant to a coumarone-derivative herbicide and /or a nucleotide sequence encoding a wild-type homogentisate solanesyl transferase or a mutated homogentisate solanesyl transferase (mut-HST) which is resistant or tolerant to a coumarone-derivative herbicide, and applying to said site an effective amount of said herbicide. Plants comprising mut-HPPD and methods of obtaining such plants are also provided.
Patent CA-2849295-A1 (CA)
Inventor: JOSECK ERIC D
IPC: C10G67/02
Filed: 2011-09-21
Abstract: L'invention concerne des procédés pour obtenir une pluralité de produits d'huile de base lubrifiante avec un rendement global amélioré. Avant le stade final d'hydrocraquage pour une montée de l'indice de viscosité, une charge pour faire une huile de base lubrifiante est fractionnée de façon à former au moins une charge pour fabriquer une huile de base lubrifiante plus légère et une charge pour fabriquer une huile de base lubrifiante plus lourde. Les points de coupe de fractionnement sont choisis de telle sorte que la fraction de charge pour former une huile de base lubrifiante légère présente une volatilité Noack supérieure et une viscosité inférieure aux cibles voulues pour l'huile de base lubrifiante plus légère. Les fractions de charge subissent ensuite un hydrotraitement séparément afin d'obtenir les propriétés voulues.
Patent CA-2850476-A1 (CA)
Inventor: YAGI TAKANOBU
IPC: G16H50/50
Filed: 2012-08-27
Abstract: [Solution] This system is a computer-based system for simulating the effect of a specific surgical treatment method on the basis of three-dimensional shape data of a targeted blood-vessel site in a subject, wherein the computer comprises: a treatment method accepting unit that three-dimensionally displays three-dimensional shape data of a targeted blood-vessel site on a display and accepts the designation of a lesion on the display and the selection of a surgical treatment method with respect to the lesion; a correction method storage unit that stores, in advance in a memory, selectable treatment methods and methods for correcting the three-dimensional shape data according to the respective treatment methods; and a corrected three-dimensional shape output unit that retrieves the correction method stored in the correction method storage unit on the basis of the selection of the treatment method, corrects the three-dimensional shape data of the designated lesion in accordance with the correction method, and outputs the corrected three-dimensional shape data.
Patent CA-2854658-A1 (CA)
Title: Methods of treating schizophrenia with phenylalanine enamide derivative inhibitors of .alpha.4 integrin possessing a cyclobutene group
Inventor: HONORE TAGE
IPC: A01N43/32
Filed: 2012-11-08
Abstract: Embodiments of the invention relate to the treatment of schizophrenia in mammals. Embodiments of the invention include methods for treating schizophrenia and/or symptoms of schizophrenia and/ or a positive symptom of schizophrenia in a psychotic disease as well as methods for preparing medicaments used in the treatment of mammalian schizophrenia. In one embodiment, methods of the invention comprise the inhibition of alpha4 integrin by a genus of compounds for the treatment of mammalian schizophrenia or a positive symptom of schizophrenia in a psychotic disease.
Patent CA-2855808-A1 (CA)
Title: Method of processing feed streams containing hydrogen sulfide
Inventor: MILAM STANLEY NEMEC
IPC: B01D53/52
Filed: 2012-11-12
Abstract: A method of processing feed streams high in hydrogen sulfide is provided. The method includes providing a feed gas stream that includes hydrogen sulfide and hydrocarbons. The feed gas stream has at least 5% by volume hydrogen sulfide. At least a portion of the feed gas stream is separated into a hydrogen sulfide stream and a hydrocarbon stream. The hydrogen sulfide stream includes more hydrogen sulfide, by volume percent, than the feed stream; and the hydrocarbon stream contains less hydrogen sulfide, by volume percent, than the feed gas stream. The hydrocarbon gas stream is processed to produce natural gas. At least 34 mol.% of the hydrogen sulfide in the hydrogen sulfide stream is combusted with an oxidant containing molecular oxygen to generate thermal power. The molar ratio of molecular oxygen to hydrogen sulfide in the hydrogen sulfide stream and oxidant that are combusted is at least 1.4:1. Thermal power generated by the combustion is utilized in one or more of the steps of separating the feed gas stream into the hydrogen sulfide stream and the hydrocarbon gas stream, and processing the hydrocarbon gas stream to produce natural gas, compressed natural gas, or liquefied natural gas.
Patent CA-2858037-A1 (CA)
Inventor: POURVASH MOJTABA
IPC: F24H3/06
Filed: 2014-07-30
Abstract: A forced air heater is provided that includes: a heating element; a heat sink mounted on the heating element; and an air mover directing air towards the heating element such that the directed air provides impinged airflow in relation to the heating element. There is also provided a heater that includes a temperature sensing device, the temperature sensing device includes: a sensing plate mounted on a metallic component in the environment to be heated; and an electrical contact connected to the sensing plate, wherein the electrical contact is thermally coupled with the metallic component via the sensing plate. There is further provided a method of controlling a heater that includes a temperature sensing device that it is thermally connected to a solid component in the environment to be heated.
Patent CA-2858866-A1 (CA)
Inventor: HOA SUONG VAN
IPC: G01N27/00
Filed: 2012-12-17
Abstract: There is provided a method and system for detecting and locating damages occurring in large structures made of polymer matrix composite materials while the structures are subjected to loading. Carbon nanotubes are added to a resin to make the latter electrically conductive. The modified resin is incorporated with long fibers to make the composite structures, which are marked with grid points where electrically conductive materials are deposited. The electrical resistances and potentials between the grid points for electrically non-conductive fibers and conductive fibers reinforced polymer composite structures are measured and used as a reference set. Since the occurrence of a damage changes the electric resistance and potential between contact points surrounding the damage, such a change serves as an indication of occurrence of the damage. The position of the damage in the structure is also determined. Damages can be detected and located in-situ while the composite structure is in operation.
Patent CA-2860248-A1 (CA)
Title: Procede de codage video utilisant un reglage de decalage selon la classification des pixels par des unites de codage maximum et appareil associe, et procede de decodage et apparei l associe
Inventor: ALSHINA ELENA
IPC: H04N19/14
Filed: 2012-12-21
Abstract: L'invention concerne un procédé de codage vidéo utilisant un réglage de décalage selon la classification de pixels par des unités de codage maximum et un procédé de décodage vidéo. L'invention concerne le procédé de codage vidéo qui consiste notamment : à déterminer un paramètre de décalage comprenant un type de décalage indiquant si le procédé de classification de la valeur de pixel de l'actuelle unité de codage maximum est de type bord ou de type bande, une classe de décalage indiquant une direction bord ou une plage bande, et une valeur de décalage indiquant des valeurs de différence parmi des pixels de récupération et des pixels originaux selon chaque unité de codage maximum ; et à sortir les informations de fusion de décalage indiquant si le côté gauche de l'actuel unité de codage maximum ou le paramètre de décalage de l'unité de codage maximum supérieure est adopté comme paramètre de décalage de l'actuelle unité de codage maximum.