Patent SG-11201908668Y-A (SG)
Title: System and method for determining native cardiac output while continuing support to the heart with a catheter-mounted intracardiac blood pump having an imbedded thermistor
Inventor: CURRAN JERALD WAYNE
IPC: A61B5/029
Filed: 2018-03-21
Abstract: 425 Th, Sensor 1 Pump 4231 Sensor 2 424 -- Therm istor Sheath 433 C° NAT 427 S IG 435 S IG 2 429 SIG 3 437 ---•\ > Pump Flow Output 439 - N Total Cardiac Output Processor (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 September 2018 (27.09.2018) WIP0 I PCT ill 1111u°11101VIIIVIIIVIIIolo VIII Em Kum niou oimIE (10) International Publication Number WO 2018/175563 Al (51) International Patent Classification: A61B 5/00 (2006.01) A61B 5/028 (2006.01) A61B 5/02 (2006.01) A61B 5/029 (2006.01) A61B 5/021 (2006.01) A61M 1/10 (2006.01) A61B 5/0215 (2006.01) A61M 1/12 (2006.01) (21) International Application Number: PCT/US2018/023539 (22) International Filing Date: 21 March 2018 (21.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/474,278 21 March 2017 (21.03.2017) US (71) Applicants: ABIOMED, INC. [US/US]; 22 Cherry Hill Drive, Danvers, MA 01923 (US). ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI [US/US]; 150 East 42nd Street - 2nd Floor, New York, NY 10017 (US). (72) Inventors: CURRAN, Jerald Wayne; 371 Summer Street, North Andover, MA 01845 (US). ISHIKAWA, Kiyotake; 2100 Linwood Avenue, 21C, Fort Lee, NJ 07024 (US). HA- JJAR, Roger J.; 46 Knoll Road, Tenafly, NY 07670 (US). (74) Agent: LARSEN, Charles D. et al.; White & Case LLP, 75 State Street, Boston, MA 02109 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (54) Title: SYSTEM AND METHOD FOR DETERMINING NATIVE CARDIAC OUTPUT WHILE CONTINUING SUPPORT TO THE HEART WITH A CATHETER-MOUNTED INTRACARDIAC BLOOD PUMP HAVING AN IMBEDDED THERMISTOR 405 452 431 FIG. 3 (57) : A system and method for determining native cardiac output of a heart while maintaining operation of an intracardiac blood pump includes determining a current drawn by the pump motor, a blood pressure within the ascending aorta, and a change in the blood temperature based on a thermodilution technique. An intracardiac blood pump positioned in the aorta includes at least one sensor for determining a motor current and blood pressure and a thermistor for determining the change in blood temperature after a precise fluid bolus has been introduced into the vasculature. A processor receives current, pressure, and temperature measurements, and calculates a pump flow output and a total cardiac output from which the native cardiac output is calculated. The native cardiac output and other clinically relevant variables derived from the measurements inform decisions related to continued therapeutic care, including increasing or decreasing cardiac assistance provided by the intracardiac pump. [Continued on next page] WO 2018/175563 Al MIDEDIM01101 DIONER13010M111111111111111111111110111111111111 SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))