baber/WOPTO huggingface dataset:
Patent SG-11201809993V-A (SG)
Title: Oncolytic viruses comprising esrage and methods of treating cancer
Inventor: KAUR BALVEEN
IPC: A61K48/00
Filed: 2017-05-11
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 16 November 2017 (16.11.2017) WIPO I PCT omit Ill Hot 0 Oil m° mi minim° oimIE (10) International Publication Number WO 2017/197207 Al (51) International Patent Classification: A61K 48/00 (2006.01) C12Q 1/70 (2006.01) C12Q 1/68 (2006.01) (21) International Application Number: PCT/US2017/032300 (22) International Filing Date: 11 May 2017 (11.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/334,589 11 May 2016 (11.05.2016) US (71) Applicant: OHIO STATE INNOVATION FOUN- DATION [US/US]; 1524 North High Street, Columbus, Ohio 43201 (US). (72) Inventors: KAUR, Balveen; MSE.R129, 6431 Fannin St , Houston, Texas 77030 (US). YOO, Ji Young; MSE.R129, 6431 Fannin St , Houston, Texas 77030 (US). (74) Agent: LANIER, J. Gibson et al.; Meunier Carlin & Cuff- man LLC, 999 Peachtree St. NE, Suite 1300, Atlanta, Geor- gia 30309 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (54) Title: ONCOLYTIC VIRUSES COMPRISING ESRAGE AND METHODS OF TREATING CANCER FIG. 2A. 0.3 c , 0.2- 0 0.1- © N 0.0 N control +antil-IMGB1 +esRAGE LN229 LN229+OV **** C (57) : Disclosed are novel modified or engineered oncolytic viruses comprising an esRAGE gene and methods for using said oncolytic virus for the treatment of a cancer.
Patent SG-11201907623R-A (SG)
Title: Reflective mask blank, reflective mask and method of manufacturing semiconductor device
Inventor: IKEBE Yohei
IPC: G03F1/26
Filed: 2018-02-20
Abstract: Provided are a reflective mask blank, having a phase shift film having little dependence of phase difference and reflectance on film thickness, and a reflective mask. 5 The reflective mask blank is characterized in that the phase shift film is composed of a material comprised of an alloy having two or more types of metal so that reflectance of the surface of the phase shift film is more than 3% to not more than 20% and so as to have a phase difference of 170 degrees to 190 degrees, and when a group of metal elements that satisfies the refractive index n and the extinction coefficient k of k > 10 a*n-Fp is defined as Group A and a group of metal elements that satisfies the refractive index n and the extinction coefficient k of k < a*n+13 is defined as Group B, the alloy is such that the composition ratio is adjusted so that the amount of change in the phase difference is within the range of ±2 degrees and the amount of change in reflectance is within the range of ±0.2% when one or more types of metal element each is selected 15 from the Group A and the Group B and the film thickness of the phase shift film has fluctuated by ±0.5% with respect to a set film thickness (provided that a: proportional constant, pi: constant).
Patent SG-11201909228V-A (SG)
Title: Encapsulated nutritional and pharmaceutical compositions
Inventor: WANG BO
IPC: A23L29/269
Filed: 2018-04-27
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT 0111111010 0111 °nolo mu Kum IIl iflo oimIE (10) International Publication Number WO 2018/195601 Al (51) International Patent Classification: A23L 33/12 (2016.01) A61K 9/16 (2006.01) A23P 10/30 (2016.01) A23D 7/00 (2006.01) A23L 29/269 (2016.01) A61K 49/18 (2006.01) A61K 47/36 (2006.01) (21) International Application Number: PCT/AU2018/050384 (22) International Filing Date: 27 April 2018 (27.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 2017901524 27 April 2017 (27.04.2017) AU (71) Applicant: CLOVER CORPORATION LIMITED [AU/AU]; 39 Pinnacle Road, Altona North, Victoria 3025 (AU). (72) Inventors: WANG, Bo; 11 Inverary Place, Parkinson, Queensland 4115 (AU). CHENG, Mek Chu Ting; 12 Aster Place, Calamvale, Queensland 4116 (AU). ELLIOTT, Glenn; 18 Ebony Court, Casuarina, New South Wales 2487 (AU). (74) Agent: DAVIES COLLISON CAVE PTY LTD; 255 Elizabeth Street, Sydney, New South Wales 2000 (AU). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) O 00 O C (54) Title: ENCAPSULATED NUTRITIONAL AND PHARMACEUTICAL COMPOSITIONS (57) : Provided herein are encapsulated compositions comprising one or more long chain polyunsaturated fatty acids (LCPU- FAs) and at least one hydrocolloid, wherein the composition has a surface free fat content of less than about 5%. Also provided are methods for stabilising emulsions comprising one or more LCPUFAs and for increasing the efficiency of encapsulation of compositions comprising one or more LCPUFAs, the methods comprising incorporating at least one hydrocolloid into the emulsions or compositions.
Patent HU-215836-B (HU)
Title: 1,2,4-triazinedione derivatives and pharmaceutical compositions comprising such compounds and process for producing them
Inventor: DR HABERKORN AXEL
IPC: C07D413/12
Filed: 1989-02-23
Abstract: Novel substituted 1,2,4-triazinediones of the general formula I 
<IMAGE>
 in which
 R<1> represents heteroaromatic radicals bonded via carbon and which are optionally substituted,
 X represents O, S, SO or SO2, R<2> represents one or more, identical or different radicals of the group comprising hydrogen, halogen, nitro, alkyl, alkoxy, haloalkyl and haloalkoxy and
 R<3> represents hydrogen, optionally substituted alkyl, alkenyl, alkynyl or aralkyl,
 process for their synthesis and intermediates therefor. The compounds of the formula I are used for combating parasitic protozoa.
Patent IS-1830-B (IS)
Inventor: KROG GABRIEL WERGELAND
IPC: G06F3/0354
Filed: 1999-01-22
Abstract: A device for operating a mouse-operated computer program. The device comprises a base (1) having an upwardly projecting handle (2) firmly secured thereto, which may also be linked to the base (1) for fixing in any desired position relative to the base. Furthermore, the handle includes an operating means (3) on top of the handle and/or on one of the sides of the handle (2), and/or on the actual base (1). A rolling means is provided on the underside of the base (1) in order to provide signals which can control the position of the mouse pointer on a computer screen. Furthermore, rolling balls or similar sliding means are provided on the underside of the base (1).
Patent DK-149888-B (DK)
Inventor: THIEME PETER C
IPC: C07D271/10
Filed: 1981-02-12
Abstract: Novel phenylpiperazinylpropanols of 1,3,4-oxadiazolylphenols and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and are useful in the treatment of hypertonia.
Patent MX-170542-B (MX)
Title: Aparato y metodo para la combustion de combustible carbonaceo
Inventor: SOLBES ALBERT
IPC: F23C1/10
Filed: 1985-11-12
Abstract: La presente invención se refiere a aparato para la combustión de combustible carbonáceo en una zona de combustión, y separación de los materiales no combustibles presentes en el combustible de los productos gaseosos de combustión, donde la zona de combustión está encerrada dentro de una cámara de combustión que tiene sus paredes mantenidas a temperaturas tales que una capa de escoria se retiene en las superficies internas de las paredes, el aparato está caracterizado porque comprende la mejora que consiste en medios para precalentar el oxidante introducido dentro de la cámara de combustión y dispositivos para agregar oxidante adicional a los productos gaseosos a medida que tales productos entran de precombustor para introducir una mezcla de aire precalentado rico en oxígeno y productos de combustión dentro de la citada cámara de combustión; una cámara de recuperación de escoria adaptada para operar subestequimétricamente para recibir productos gaseosos de combustión de la cámara de combustión, recuperar materiales no combustibles residuales de tales productos en la forma de escoria derretida y desechar por separado la escoria derretida, con ello proporcionando productos gaseosos ricos en combustible, relativamente libres de escoria, para entrega a un equpo de utilización de calor asociado y medios para conducir los productos gaseoso relativamente libres de escoria de la cámara de recuperación de escoria a un equipo de utilización de calor asociado.
Patent YU-41914-B (YU)
Title: Process for obtaining new tri peptides
Inventor: GOLDSTEIN G
IPC: C07C237/22
Filed: 1980-03-14
Abstract: There are disclosed new biological active polypeptides:wherein A is deamino-LYS or LYS; X is a suitable neutral aliphatic amino acid residue; e.g., one selected from the group consisting of SER, ALA, 2-Me-ALA, GLY, LEU, THR, D-SER, D-ALA, D-THR, allo-THR, D-LEU, and SAR; B is GLN-R', decarboxy-GLN, orand R' is a substituent which does not substantially affect the biological activity of the tripeptide.These polypeptides have the capability of inducing the differentiation of T lymphocytes as measured by the acquisition of the thymic differentiation antigen Th-I, as well as B-lymphocytes as measured by the acquisition of the differentiation antigen Bu-i. The polypeptides are thus useful in thymic function and immunity areas such as in treatment for congenital absence of thymus. Also provided are therapeutic compositions and methods for use of the polypeptides.
Patent YU-48850-B (YU)
Inventor: BRANKO DOKIC PROF DR
Filed: 1993-12-29
Abstract: Trostatički BiCMOS bafer, koji se sastoji od osam MOS tranzistora i tranzistora Q1, Q2, kao baze, naznačen time, što su za ulaze (E,X) spojeni na red vezani tranzistori (M1, M2, M3), dok je za tranzistor (M3) paralelno vezan tranzistor (M4), koji je vezan i sa tranzistorom (M2) i tranzistorom (Q2) kao bazom; što su za ulaz (E) spojeni na red tranzistori (M5, M8, M7), dok je za tranzistor (M5) paralelno vezan tranzistor (Q1) kao bazom, tranzistorom (M8) ulazom (X) i preko njega sa tranzistorom (M7), koji je povezan sa tranzistorom (Q1), što je tranzistor (M3) povezan sa tranzistorom (M5) i tranzistorom (M8) preko ulaza (E), što je tranzistor (M4) povezan za tranzistore (Q1, M5, M6, M8) i što je tranzistor (M1) povezan za tranzistore (Q1, Q2) a sa njima na izlaz (Y).
Patent YU-46860-B (YU)
Inventor: MACHIN P J
IPC: A61K31/7042
Filed: 1988-05-13
Abstract: POSTUPAK ZA PROIZVODNJU DERIVATA PIRIMIDINA, i njihovih amida i sifove baze, naznacen time, sto se (a) uklanja grupa 3'-hidroksi iz jedinjenja opste formule u kojoj R10 predstavlja esterifikovanu hidroksi grupu, i ako se zeli, ova esterifikovana hidroksi grupa R10 u dobijenom proizvodu prevodi u hidroksi grupu, ili (b) radi spravljenja jedinjenja formule I u kojoj R1 predstavlja esterifikovani hidroksi, esterifikuje jedinjenje formule I u kojoj R1 predstavlja hidroksi, ili (c) radi spravljenja amida ili sifove baze jedinjenja formule I, prevodi jedinjenje formule I u amid ili sifovu bazu. Prijava sadrzi jos 1 zavisan zahtev.
Patent ZA-84896-B (ZA)
Title: Mixtures of fsh and lh from pig hypophyses in a definite ratio
Inventor: BARBETTI MANLIO
IPC: A61K38/00
Filed: 1984-02-07
Abstract: The mixtures of FSH (a follicle stimulating hormone) and LH (a luteinizing hormone) being extracted from pig hypophyses in a definite ratio, improve to an optimum level the induction of super-ovulation in bred animals.
Patent ZA-95698-B (ZA)
Title: Medicaments containing 3-benzoyl-3,7-diazabicyclo-(3.3.1)nonane compounds
Inventor: SCHON UWE
IPC: A61K31/495
Filed: 1995-01-30
Abstract: Use of 3-benzoyl-3,7-diazabicyclo(3,3,1) -nonane derivs. of formula (I) and their acid addn. salts is claimed in the treatment of disorders of heart rhythm in large mammals and humans. R1 = 1-6C alkyl or 4-7C cycloalkylalkyl; R2, R3 = lower alkyl; or R2+R3 = 3-6C alkylene; R4 = H, halogen, CN, NO2, CF3 or SO2R6; R5 = H, halogen, CF3 or NO2; R6 = F or lower alkyl.
Patent ZA-97325-B (ZA)
Title: Square anti-symmetric uniformly redundant array coded aperture imaging system.
Inventor: CHIOU WALTER CHING-HWEI
IPC: G01T1/20
Filed: 1997-01-15
Abstract: A square anti-symmetric uniformly redundant array coded aperture includes transparent and opaque cells and exhibits a normal mask pattern at a first position and a complementary mask pattern when rotated to a second position rotationally offset by 90 DEG  from the first position. The coded aperture is utilized in a coded aperture imaging system for imaging a source of non-focusable radiation such as a gamma ray or x-ray emitting source. Such a coded aperture imaging system basically includes a square anti-symmetric uniformly redundant array coded aperture for receiving radiation emitted by a source and generating a first coded shadow therefrom at the first position, and a second coded shadow therefrom at the second position, a rotating platform and motor for rotating the coded aperture between the first and second position, a position sensitive detector situated with respect to the coded aperture to allow the first and second coded shadows to sequentially impinge on the detector, the detector respectively generating a first coded optical signal and a second coded optical signal in response thereto, an optical signal convertor responsive to the first and second coded optical signals and respectively generating a first coded electrical signal and a second coded electrical signal in response thereto and a signal processor responsive to the first and second coded electrical signals and decoding the coded electrical signals to generate an image signal which is representative of an image of the source of non-focusable radiation.
Patent ZA-98378-B (ZA)
Title: Guiding means for continuous castings in particular for a continuous slab-casting plant
Inventor: WYL HORST VON
IPC: B22D11/128
Filed: 1998-01-16
Abstract: A strand guide, in particular for a continuous slab-casting plant for steel, with supporting segments in which frames are arranged that have rows of guide rollers and driving rollers arranged opposite one another, wherein the frames are held opposite one another by tie rods. Two guide members are provided at one end of a frame at equal distance from the center axis. The guide members are fastened to at least one fixed point via holding elements and are arranged conically at an opening angle relative to one another.
Patent AT-383130-B (AT)
IPC: C07F9/10
Filed: 1984-05-15
Granted: 1987-05-25
Abstract: Preparation of chemically defined pure enantiomeric 1,2-diacyl-sn-glycero-3-phosphocholines and 1,2-diacyl-sn-glycero-3-phosphoethanolamines which are substituted in positions 1 and 2 of the glycerol, by acylation of triphenylmethyl derivatives of sn-glycero-3-phosphocholine and sn-glycero-3-phosphoethanolamine.
Patent AT-409856-B (AT)
Title: Lifting unit for a generally torsion-resistant frame, specifically for a container
IPC: B66F3/46
Filed: 1999-10-25
Granted: 2002-12-27
Abstract: A lifting unit for a generally torsion-resistant frame (7), specifically for a container with four lift feet (2, 3) opposing each other on the frame (1) in pairs is described, which have hydraulically powered adjusting cylinders (4, 5) that are adjustable through control valves (6, 9). In order to produce favourable structural conditions, it is recommended that the adjusting cylinders (4) of a lift foot pair (2) are separately powered by independent control valves (6) and that the adjusting cylinders (5) of the other lift foot pair (3), hydraulically connected via pressure equalising ducts on both sides, may be acted on by means of a common control valve (9).<IMAGE>
Patent AT-406030-B (AT)
Title: Autonomous, self-propelled, trackless work-carrier trucks capable of being coupled
Inventor: STUBENVOLL WOLFGANG DIPL ING D
IPC: B65G35/00
Filed: 1994-11-24
Granted: 2000-01-25
Abstract: At present, positively guided work-carrier plates on a rigid circulating belt system for interlinking the material flow between machining stations and driverless industrial trucks are used for the transport of materials in production plants. The tasks of the currently used work-carrier plates and driverless transport systems can be performed by the autonomous, self-propelled (driverless), intelligent, trackless and self-orienting work-carrier trucks capable of being coupled which are proposed here. These work-carrier trucks have a separate power supply, a steered and driven chassis for propulsion, sensors for measuring the surroundings, an on-board computer for determining the position by means of the measured values from the sensors and require only a level surface as roadway. In addition, the work-carrier trucks are equipped with a coupling mechanism on the side faces. With this coupling mechanism, they can be coupled together to form a flat- spread combination of work-carrier trucks. It is thus possible to dimension the work-carrier trucks according to the carrying load or to dimension them on the basis of the requisite size of the loading area. The properties of the individual work-carrier trucks also apply to the combination, so that the combination also has the properties of being autonomous, self-propelled (driverless), intelligent, trackless, capable of being coupled and self-orienting. <IMAGE>
Patent AT-388914-B (AT)
Inventor: GREBER GERD PROF DR ING
IPC: C07C317/14
Filed: 1987-11-16
Granted: 1989-09-25
Abstract: PCT No. PCT/EP88/01017 Sec. 371 Date Jun. 12, 1990 Sec. 102(e) Date Jun. 12, 1990 PCT Filed Nov. 10, 1988 PCT Pub. No. WO89/04298 PCT Pub. Date May 18, 1989.Aromatic tetracarboxylic acids or derivatives thereof of the general formula I   <IMAGE> I  in which R denotes a divalent radical of the formula II   <IMAGE> II  Ar denotes tri- or tetravalent aromatic radicals or mixtures thereof, X, if Ar is trivalent, denotes an amide radical, and if Ar is tetravalent denotes an imide radical, and Y and Z either together denote the anhydride radical -CO-O-CO- or by themselves and independently of one another denote the radicals -COOH, -COCL or -COOR1, and a process for their preparation.
Patent CH-623193-B (CH)
Inventor: ERARD RAOUL-HENRI
IPC: G04B27/02
Filed: 1977-05-09
Abstract: The back cover (51) of the watch case carries a middle-bezel and forms a plate. At its center there are superimposed and concentrically pivoted, respectively, a ratchet crown-wheel (1.6) inside which a mainspring is housed, driving a core (1.3) fast with an hour-disc (1.1) comprising a toothing on its periphery, and a transparent minute-disc (1.2) comprising also a toothing on its periphery. These discs mesh on the one hand with a drive train (2, 3, 4) by which the minute-disc is driven by the hour-disc and, on the other hand with a winding and time-setting mechanism both located outside of the discs and at least partially at the same height as these discs.
Patent DK-159494-B (DK)
Inventor: GJELSTRUP LARS
IPC: B65B67/12
Filed: 1988-08-17
Abstract: In order to permit easy and hygienical disposal of e.g. sanitary towels in a cloakroom, a bag retainer can be fitted on the wall, and a bag (4) can be hung on the retainer. The retainer comprises a traversing resilient carrier rail (3) on which a bag is hung (4) which is provided with a flap (5) at its mouth and which is downwardly open and designed to fit the reception of the carrier rail (3). The flap (5) and the carrier rail (3) have sloping side edges (7, 8) and are dimensioned so as to allow the bag to slide further down over the carrier rail (3) once the bag is stretched lengthwise with a view to keeping the rim stretched and the bag closed. When the mouth of the bag is to be opened, one pulls out the uttermost part of the mouth, and when the bag is to be closed, one lets go of the mouth part whereby the resilient carrier rail will close the mouth of the bag.
Patent DK-161887-B (DK)
Inventor: FOSTER BENNIE JOE
IPC: A61K31/085
Filed: 1981-11-13
Abstract: The (-)-enantiomer of the compound of formula (I): <CHEM> and its pharmaceutically-acceptable salts, are effective anti-depressant agents.
Patent DK-162884-B (DK)
Inventor: KRAUSS WERNER
IPC: B65D88/72
Filed: 1985-12-10
Abstract: Bulk silo with essentially centrally located aerated mixing or homogenizing chamber whose wall comprises a plurality of permanent passage openings for the material from the main silo area and is connected to an inspection area. In order to improve inspection and service, the inspection area is formed by a hollow column which is accessible from below, is located inside the chamber and comprises observation openings into the chamber as well as comprising the vent line.
Patent DK-160460-B (DK)
Title: Insulin preparation for nasal or rectal administration, and use of an insulin derivative for producing the preparation
Inventor: BALSCHMIDT PER
IPC: C07K14/62
Filed: 1987-12-08
Abstract: PCT No. PCT/DK87/00038 Sec. 371 Date Dec. 14, 1987 Sec. 102(e) Date Dec. 14, 1987 PCT Filed Apr. 14, 1987.Insulin preparations for non-parenteral administration and containing one or more insulins or insuling derivatives, which in solution in the physiological pH range predominantly are present as monomers, usual additives and possibly a conventional insulin and possibly one or more adsorption promoting substances provide a fast absorption of the insulin activity administered.