Patent SG-11201805792P-A (SG)
Title: Chimeric proteins and methods of regulating gene expression
Inventor: QI LEI S
IPC: C12N15/90
Filed: 2017-01-10
Abstract: FIGURE101 102 W O 20 17 / 12355 9 A2 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/123559 A2 20 July 2017 (20.07.2017) WIPO I PCT (51) International Patent Classification: C12N 15/90 (2006.01) C12N 9/22 (2006.01) (21) International Application Number: PCT/US2017/012885 (22) International Filing Date: 10 January 2017 (10.01.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/277,322 11 January 2016 (11.01.2016) US 62/351,522 17 June 2016 (17.06.2016) US 62/399,902 26 September 2016 (26.09.2016) US (71) Applicant: THE BOARD OF TRUSTEES OF THE LE- LAND STANFORD JUNIOR UNIVERSITY [US/US]; Office of the General Counsel, Building 170, Third Floor, Main Quad, P.O. Box 20386, Stanford, California 94305- 2038 (US). (72) Inventors: QI, Lei S.; c/o The Board of Trustees of the Le- land Stanford Junior University, Office of the General Counsel, Building 170, Third Floor, Main Quad, P.O. Box 20386, Stanford, California 94305-2038 (US). DINGAL, P.C. Dave P.; c/o The Board of Trustees of the Leland Stanford Junior University, Office of the General Counsel, Building 170, Third Floor, Main Quad, P.O. Box 20386, Stanford, California 94305-2038 (US). (74) Agents: HAO, Joe C. et al.; Kilpatrick Townsend & Stockton LLP, Mailstop: IP Docketing - 22, 1100 Peachtree Street, Suite 2800, Atlanta, GA 30309 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) Published: without international search report and to be republished upon receipt of that report (Rule 48.2(g)) (54) Title: CHIMERIC PROTEINS AND METHODS OF REGULATING GENE EXPRESSION (57) : The present disclosure provides systems, compositions and methods for regulating expression of a target polynuc - leotide in a cell. The systems, compositions and methods comprise a chimeric receptor polypeptide, a chimeric adaptor polypeptide, at least one actuator moiety and a cleavage moiety. 111111111111110111011111111111010111110 01111111101111111111111110111111111110111111