Patent SG-11201901092U-A (SG)
Title: Reconfigurable surface enhanced raman spectroscopy device and method therefor
Inventor: DIES HANNAH
IPC: G01N21/65
Filed: 2017-08-04
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property C.--.` 111111101111 0 DOI HIM 011101 0 011101010111111110110 111110 ill OEN Organization International Bureau (10) International Publication Number 03 (43) International Publication Date .../ WO 2018/027309 Al 15 February 2018 (15.02.2018) WIP0 I PCT (51) International Patent Classification: DO, Carlos; 1016 Mona Drive, Kingston, Ontario K7P 2P6 GO1N 21/65 (2006.01) (CA). (21) International Application Number: (74) Agent: SCRIBNER, Stephen J.; Office of Partnerships PCT/CA2017/050931 and Innovation, Queen's University at Kingston, 99 Univer- (22) International Filing Date: sity Avenue, Kingston, ON K7L 3N6 (CA). 04 August 2017 (04.08.2017) (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (26) Publication Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (30) Priority Data: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, 62/373,537 11 August 2016 (11.08.2016) US HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (71) Applicant: QUEEN'S UNIVERSITY AT KINGSTON MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, [CA/CA]; Queen's University, Kingston, Ontario K7L 3N6 OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (CA). SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (72) Inventors: DIES, Hannah; 140 Yonge Street, Kingston, Ontario K7M 1G1 (CA). DOCOSLIS, Aristides; 697 Tan- (84) Designated States (unless otherwise indicated, for every ner Drive, Kingston, Ontario K7M 8Y2 (CA). ESCOBE- kind of regional protection available): ARIPO (BW, GH, = (54) Title: RECONFIGURABLE = — = SURFACE ENHANCED RAMAN SPECTROSCOPY DEVICE AND METHOD THEREFOR 13a 14 ASSEMBLE -- (a) 16 12a -- 1 2b \L Remove droplet Fir =e. 18 CPILECI _ — (b)18a - __ _ _ ' = ev ' P fill:•n Y'e 'I rer = = = = = 16a a i — 13b Reassemble Reuse 10 Remove Rinse droplet ----- SERS 4 — Sacctrian_ _ ...4... = = = — Rem cl2ndrite _ = ill _ _ = 0.• 4 t - REGENERATE MEASURE Il Fig. 1 01 © en (57) : A surface enhanced Raman spectroscopy (SERS) device, comprises a non-electrically conductive substrate, at least IN two microelectrodes disposed on the substrate in a spaced relationship such that a detection site is formed along edges and/or between 0 el opposing edges of the microelectrodes, and a nanoparticle structure comprising a plurality of metallic nanoparticles disposed in the ----. detection site. Assembly of the nanoparticle structure may be directed by an electric field between the at least two microelectrodes. GC The SERS device is inexpensive, robust, portable, and reusable. Also described herein are methods for using and preparing the SERS 1-1 © devices with simple, rapid, and inexpensive fabrication techniques. N C [Continued on next page] WO 2018/027309 Al MIDEDIMOMOIDEIREIO I 0 10 1101 VIII VIII VIII VIII IIII1111111IIII IIII IIII GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))