baber/WOPTO huggingface dataset:
Patent CA-2690913-C (CA)
Inventor: PATTERSON JOHN BRUCE
IPC: C07D295/00
Filed: 2008-06-09
Granted: 2017-05-23
Abstract: Compounds which directly inhibit IRE- 1.alpha. activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. These compounds are represented by formula (B): (see formula B) Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.
Patent CA-2693182-C (CA)
Inventor: CHEN WEIRONG
IPC: A61P29/00
Filed: 2008-06-30
Granted: 2018-01-02
Abstract: La présente invention porte sur des composés utiles en tant qu'inhibiteurs de la protéine kinase Raf. La présente invention porte également sur des compositions de ceux-ci, et sur des procédés pour le traitement des maladies à médiation par Raf.
Patent CA-2693199-C (CA)
Title: Dispositif resisitif comportant des couches de films minces stratifiees faisant intervenir une bande dielectrique
Inventor: BRUMMELL ROGER
IPC: H01C17/065
Filed: 2008-07-17
Granted: 2013-09-10
Abstract: L'invention concerne un dispositif résisitif servant à fournir une charge résistive à une cible dans des conditions d'application d'une puissance provenant d'une source de puissance. Le dispositif résistif est conçu pour être électriquement connecté à la source de puissance par deux fils de connexion. Le dispositif résistif comprend une matière formant film mince définissant au moins une couche de bande. Le dispositif résistif peut être, par exemple, un dispositif de chauffage ou une résistance de charge, et peut comprendre un substrat sur lequel est appliquée une couche de bande électrique, une couche résistive appliquée sur la couche de bande diélectrique, et une couche de protection appliquée sur la couche résistive.
Patent CA-2694568-C (CA)
Inventor: GISBY DOUGLAS
IPC: H04M3/56
Filed: 2010-02-25
Granted: 2014-10-14
Abstract: Systems and methods are described that for authenticating participants in a conference call. One method may include: providing a first primary communication device having a first security token generator configured to generate first security tokens; providing a second primary communication device; providing a conference call controller configured to receive and authenticate security tokens; establishing a first control link between the first primary communication device and the conference call controller; generating a first security token; communicating the first security token between the first primary communication device and the conference call controller via the first control link; authenticating the first security token; and establishing a media link between the first and second primary communication devices via the conference call controller. In some embodiments, the first control link may comprise a WiFi connection.
Patent CA-2701100-C (CA)
Inventor: BESSETTE TYLER JON
IPC: G01D11/26
Filed: 2008-10-23
Granted: 2015-04-28
Abstract: The present disclosure provides for systems and methods for fabricating measuring devices, e.g., a pressure gauge, thermometer or the like. More particularly, the present disclosure provides for systems and methods for fabricating measuring device assemblies having at least a case, window and gasket, where the measuring device can be assembled in multiple different ways using the same case, window and gasket. The case includes at least three projections and at least three case protrusions. The window has at least three clearance notches, at least three window protrusions, and a groove with a bottom lip.  The gasket is sized to rest in the groove. The notches are configured to allow the projections to bypass the notches when they are aligned during assembly of the window.
Patent CA-2706442-C (CA)
Inventor: CONNELLY MARK CARLE
IPC: G01N15/00
Filed: 2008-10-20
Granted: 2017-07-11
Abstract: The CellTracks® System provides a system to enumerate circulating melanoma cells in blood. The system immuno-magnetically concentrates epithelial cells, fluorescently labels the cells and identifies and quantifies circulating melanoma cells. The absolute number of circulating melanoma cells detected in the peripheral blood tumor load is, in part, a factor in prediction of survival, time to progression, and response to therapy. Diagnosis and monitoring of melanoma has been limited by the inability to monitor circulating melanoma cells. The present invention provides a method to enumerate circulating melanoma cells in blood samples. Accordingly, this technology provides a means and device for monitoring disease progression in patients with melanoma.
Patent CA-2711783-C (CA)
Inventor: BURTON DAVID
IPC: A61B5/0205
Filed: 2003-10-09
Granted: 2016-12-20
Abstract: The present invention monitors and interprets physiological signals and spontaneous breathing events to detect the onset of arousal. Once the onset of arousal is determined, the present invention determines adjustments that are needed in the operation of a therapeutic device to avoid or minimize arousals. In one embodiment, the present invention includes one or more sensors which detect a patient's physiological parameters, a controller which monitors and determines the onset of arousal based on the physiological variables received from the sensor, and a therapeutic treatment device which is controlled by the controller. The sensor can be a combination of one or more devices which are able to monitor a physiological parameter that is used by the present invention to determine the onset of arousal or the onset of a sleep disorder. The sensors can be integrated into one unit or may operate independent of the others.
Patent CA-2715312-C (CA)
Inventor: NIELSEN STEVEN E
IPC: G06F17/00
Filed: 2009-02-11
Granted: 2012-02-07
Abstract: Methods and apparatus for generating a searchable electronic record of a locate operation in which a presence or an absence of at least one underground facility within a dig area may be identified using one or more physical locate marks.  Source data representing one or more input images of a geographic area comprising the dig area is received and processed so as to display at least a portion of the input image(s) on a display device. One or more digital representations of the physical locate mark(s) applied to the dig area during the locate operation are added to the displayed input image(s) as 'locate mark indicators' so as to generate a marked-up image. Information relating to the marked-up image is electronically transmitted and/or electronically stored so as to generate the searchable electronic record of the locate operation.
Patent CA-2716093-C (CA)
Inventor: TAMM CARSTEN
IPC: H04R5/04
Filed: 2010-09-30
Granted: 2013-01-15
Abstract: An audio jack for an audio plug for use in an electrical device, comprising a non-conductive enclosure having a front side and defining a cavity having an aperture within the front side for receiving the audio plug, the aperture having a first diameter, the cavity extending along a longitudinal axis; a conductive shielding formed from sheet metal folded over at least five sides of the enclosure including the front side, the shielding defining a shielding aperture centered on the enclosure aperture and having a second diameter larger than the first diameter; and a ground contact connected to the conductive shielding.
Patent CA-2724470-C (CA)
Inventor: CHEN LISA RUDERMAN
IPC: A61K31/7076
Filed: 2009-05-13
Granted: 2018-01-02
Abstract: A method of treating or preventing a disease or condition in a subject that was previously treated with at least one thienopyhdine is described. The method includes administering to the subject an effective amount of at least one reversible, short-acting P2Yi2 inhibitor. The described method can be used for subjects diagnosed with symptoms such as stable or unstable angina, vascular ischemic events, atherosclerosis, acute coronary syndrome, as well as STEMi or N-STEMI. The described method can also be used for patients having previously received a stent, such as a bare metal stent or a drug-eluting stent, and the treatment or prevention of stent thrombosis. The method can be used prior to, during, or after an invasive procedure such as coronary artery bypass grafting, percutaneous coronary intervention, or other general surgical procedure.
Patent CA-2725110-C (CA)
Inventor: MATSUKAWA TATSUYA
IPC: C07D333/36
Filed: 2009-05-29
Granted: 2017-08-22
Abstract: The present invention provides a benzene derivative or thiophene derivative useful as a VAP-1 inhibitor, or a medicament for the prophylaxis or treatment of a VAP-1 associated disease and the like, namely, a compound represented by the formula (I): (see formula I) wherein each symbol is as defined in the present specification, or a pharmaceutically acceptable salt thereof.
Patent CA-2728012-C (CA)
Title: Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life
Inventor: WEIMER THOMAS
IPC: G01N33/86
Filed: 2009-06-24
Granted: 2017-10-31
Abstract: The present invention relates to modified nucleic acid sequences coding for coagulation factor VIII (FVIII) and for von Willebrand factor (VWF) as well as complexes thereof and their derivatives, recombinant expression vectors containing such nucleic acid sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives coded for by said nucleic acid sequences which recombinant polypeptides and derivatives do have biological activities together with prolonged in vivo half-life and/or improved in vivo recovery compared to the unmodified wild-type protein. The invention also relates to corresponding FVIII sequences that result in improved expression yield. The present invention further relates to processes for the manufacture of such recombinant proteins and their derivatives. The invention also relates to a transfer vector for use in human gene therapy, which comprises such modified nucleic acid sequences.
Patent CA-2730377-C (CA)
Title: Derives de tetracycline presentant une activite antibiotique reduite et des benefices neuroprotecteurs
Inventor: DUNCAN IAIN W
IPC: A61P25/28
Filed: 2009-07-10
Granted: 2017-09-19
Abstract: La présente invention concerne des compositions et des procédés qui utilisent le squelette de tétracycline, de préférence le squelette de minocycline, et qui manquent significativement dactivité antibiotique. Les composés ont des attributs neuroprotecteurs sans interférer avec la capacité des médicaments de traverser la barrière hémato-encéphalique. Ces composés possèdent une activité neuroprotectrice à cause de leur inhibition de la progression du cycle cellulaire neuronal. Les composés sont caractérisés en partie par un cinquième cycle joignant les positions 9 et 10.
Patent CA-2730728-C (CA)
Title: Embolic coil implant system
Inventor: TOMPKINS BEN
IPC: A61B17/12
Filed: 2009-07-10
Granted: 2019-10-29
Abstract: Embolic coil implant systems whereby coils (16, 116, 216) are mechanically detachable are disclosed. The coils include a retention element (32, 132, 232) that may be releasably retained within the distal end of an implant tool (14, 114, 214).  The implant tool may include a fulcrum (120) configured to engage a first filament (30) and prevent the release of the coil when the first filament is engaged. Alternatively, an urging means (240) and aperture (244) may be disposed within the sidewall of the implant tool, and a first filament may, in conjunction with the aperture and sidewall, releasably retain the coil until the first filament is withdrawn. The implant tool may also include an alignment member (228) for aligning the first filament.
Patent CA-2736035-C (CA)
Inventor: FOLTZ FORREST C
IPC: G06F12/1009
Filed: 2009-09-26
Granted: 2016-07-05
Abstract: Page tables in the last level of a hierarchical page table system are scanned for candidate page tables. Candidate page tables are converted to large pages, having a page table entry in a level before the last level of the hierarchical page table system adjusted to be associated with the newly created large page. Upon receiving a notification that a large page is to be converted into a page table, a new page table is created. Each entry in the new page table is associated with a small segment of memory in the large page and an entry in a page table one level before the last level in a hierarchical page table system is adjusted to be associated with the new page table.
Patent CA-2736873-C (CA)
Inventor: VICARI RICHARD
IPC: C08F8/12
Filed: 2009-09-11
Granted: 2014-04-08
Abstract: Disclosed herein is a water-soluble copolymer formed by copolymerizing N-vinylformamide and one or more vinyl C1-C10 alkyl esters, and then hydrolyzing from 30 to 100 mol% of the formyl groups from the copolymerized units to form amino groups and from 30 to 100 mol% of the C1-C10 alkyl ester groups from the copolymerized units to form hydroxyl groups, wherein the copolymer has a unimodal molecular weight distribution as evidenced by essentially one peak in a gel permeation gradient elution chromatographic analysis. A process to produce the polymer is also disclosed.
Patent CA-2740451-C (CA)
Inventor: ULLRICH PETER F JR
IPC: A61L27/06
Filed: 2011-05-16
Granted: 2014-01-28
Abstract: An interbody spinal implant including a body, the body comprising: a top surface; a bottom surface; opposing lateral sides; and opposing anterior and posterior portions; the top surface, bottom surface, opposing lateral sides, internal wall surface, and opposing anterior and posterior portions defining a substantially hollow center having a single vertical aperture defining an internal wall surface, the single vertical aperture (a) extending from the top surface to the bottom surface, (b) having a size and shape predetermined to maximize the surface area of the top surface and the bottom surface available proximate the anterior and posterior portions while maximizing both radiographic visualization and access to the substantially hollow center, and (c) defining a transverse rim, wherein at least a portion of the internal wall surface has a roughened surface topography.
Patent CA-2750923-C (CA)
Title: Systems, methods and apparatus relating to generation, transmission, access and storage of virtual white line (vwl) images and data for excavation projects
Inventor: NIELSEN STEVEN
IPC: E02D1/02
Filed: 2010-01-20
Granted: 2014-03-18
Abstract: Systems, methods and apparatus for facilitating detection of a presence or an absence of at least one underground facility within a dig area. Source data representing one or more input images of a geographic area including the dig area is electronically received at a first user location, which may be remote from the dig area. The source data is processed so as to display at least a portion of the input image(s) on a display device. One or more indicators are added to the displayed input image(s), via a user input device associated with the display device, to provide at least one indication of the dig area and thereby generate a marked-up digital image. In one example of a staged excavation project, the input image, or a plurality of associated images, may be marked-up to include multiple dig area indicators corresponding to multiple stages of the staged excavation project.
Patent CA-2751228-C (CA)
Inventor: WOCHNER HANNS
IPC: C01B33/02
Filed: 2011-08-31
Granted: 2013-10-01
Abstract: The invention relates to a method for producing thin silicon rods (1), comprising the steps: a) providing a rod of polycrystalline silicon, from which at least two thin rods (11, 12) with a reduced cross section in comparison with the polycrystalline silicon rod are separated; b) cleaning the at least two separated thin rods (11, 12) by treatment with a material-eroding liquid medium; c) welding at least two of the cleaned thin rods (11, 12) to form a longer thin rod (1); d) packaging the longer thin rod (1) in a tubular film (100).
Patent CA-2751918-C (CA)
Inventor: ST LAURENT MICHAEL
IPC: H04L12/24
Filed: 2011-09-08
Granted: 2019-02-26
Abstract: A system and method are provided for updating location information associated with a printer resource stored in a printer resource registry in a network resource access system. Updating the location information for the printer resource may involve obtaining a unique identifier for the printer resource, determining the location of the printer using GPS or other location based services, authenticating access to the printer resource registry, and submitting the location information to the printer resource registry. Systems for updating location information in the resource registry may operate on the printer resource by itself or in conjunction with a mobile device. System may operate autonomously or provide a user interface for a system administrator to update location information.
Patent CA-2752099-C (CA)
Inventor: WEISS ANDREAS
IPC: G01S13/22
Filed: 2010-02-09
Granted: 2017-02-07
Abstract: The invention relates to a method for detecting wind power plants using a radar system, wherein a. a number N of specifiable trains B x, where x=1,...,N, of K modulated transmitted pulses, each having a specifiable pulse train frequency, is emitted consecutively; b. a specifiable number of pulse train frequencies is used; c. after each emitted train, cyclically a switch to another pulse train frequency is made; d. transmitted pulses reflected by an object are received by the radar system and processed such that received pulses corresponding to the transmitted pulses are created, wherein for each transmitted pulse a number R of received pulses is received; e. the received pulses associated with the trains Bx of modulated transmitted pulses are used to determine the distance from the object by way of signal propagation time measurement, and a distance Doppler matrix having R lines and N*K columns is produced; f. in an azimuth region cyclically a number M of measurement processes is carried out in an azimuthal direction, wherein during each measurement process N trains B x of modulated transmitted pulses are emitted in the respective azimuthal direction, and for each measurement process M a distance Doppler matrix is produced, g. sampling values of Z, where Z=2...N, trains B N of modulated transmitted pulses from M measurement processes are strung together using a specifiable correction term and are processed, wherein by way of a maximum likelihood estimator a harmonic oscillation having the least square deviation from the sampling values is calculated; h. by applying the maximum likelihood estimator, a results matrix having R lines and N/Z columns is calculated from the distance Doppler matrix having R lines and N*K columns, wherein for each cell the signal strength, phase and Doppler frequency of the object is known; i. after the steps a)-h) consecutively two results matrixes El, E2 are produced, which are compared to each other, wherein a distance Doppler cell is marked as the site of a wind power plant if i. the signal strength of a distance Doppler cell in both results matrixes (E1, E2) is above a specifiable threshold value, and ii. the Doppler frequency shift in a distance Doppler cell in both results matrixes (E1, E2) is within a value range customary for a wind power plant, and iii. the difference of the Doppler frequencies in a distance Doppler cell in both results matrixes (E1, E2) is below a specifiable threshold value.
Patent CA-2752319-C (CA)
Inventor: ALCARAZ MARIE-LYNE
IPC: A61K31/4439
Filed: 2010-02-18
Granted: 2016-10-04
Abstract: La présente invention concerne le 6-méthyl-5-(I-méthyl-1 H-pyrazol-5-yl)-N-{[5-(méthylsulfonyl)pyridin-2-yl]méthyl}-2-oxo-1-[3-(trifluorométhyl)phényl]-1,2-dihydropyridine-3-carboxamide 4-méthylbenzènesulfonate et sa nouvelle forme cristalline ainsi que des procédés de préparation dudit sel et de ladite forme, des compositions pharmaceutiques comprenant ladite forme, et l'utilisation dudit sel et de ladite forme en traitement.
Patent CA-2755123-C (CA)
Inventor: TIIHONEN MARIKA
IPC: C01D15/08
Filed: 2010-03-01
Granted: 2016-08-23
Abstract: The invention relates to a method for purifying impure lithium bicarbonate by means of a cation exchange resin. In addition to solution purification by ion exchange, the treatment stages include the regeneration of impurity metals bound to the resin. Regeneration consists of washing the resin with water, elution with acid solution, washing with water, neutralisation with alkali solution and washing with water. It is characteristic of the method that neutralisation is performed with sodium hydroxide solution.
Patent CA-2761019-C (CA)
Inventor: BOYLE JOHN
IPC: E21B23/00
Filed: 2010-05-06
Granted: 2016-11-01
Abstract: A liner string for a well has a liner hanger assembly at an upper portion of the liner string.  A profile sub is located at a bottom portion of the liner string. A bottom hole assembly is latched to the profile sub. The operator lowers the liner string into the well with a drill pipe string and rotates the drill pipe string to rotate the drill bit to deepen the well. At a selected depth, the operator releases the bottom hole assembly from the profile sub and reverse circulates drilling fluid from a liner annulus surrounding the liner string, pumping the bottom hole assembly up the liner string. When the bottom hole assembly reaches the lower end of the drill pipe string, it latches to a catcher tool located at the lower end of the drill pipe string. The operator moves the liner hanger assembly into setting engagement with the casing string, releases the drill pipe string from the liner string, and retrieves the drill pipe string along with the bottom hole assembly.
Patent CA-2763810-C (CA)
Inventor: JONES J BRYAN
IPC: C11D3/386
Filed: 1997-11-24
Granted: 2013-04-02
Abstract: Modified enzymes are provided in which at least one amino acid, such as asparagine, leucine, methionine or serine, of an enzyme is replaced with a cysteine and the thiol hydrogen is replaced with a substituent group providing a thiol side chain selected from the group consisting of: a) -SR1R2, wherein R1 is an alkyl and R2 is a charged or polar moiety; b) -SR3, wherein R3 is a substituted or unsubstituted phenyl; c) -SR4, wherein R4 is substituted or unsubstituted cyclohexyl; d) -SR5, wherein R5 is C10-C15 alkyl; and e) -SR6 wherein R6 is a C1-6 alkyl. Also, methods of producing the modified enzymes are provided, as well as detergent and feed additives and a composition for the treatment of a textile. A method for using the modified enzymes in organic synthesis is additionally provided. Further, modified enzymes having improved activity, altered pH profile and/or wash performance are provided.
Patent CA-2769226-C (CA)
Title: Amelioration de securite d'un reseau optique passif base sur une interface de commande de gestion de terminal de reseau optique
Inventor: FRANK J EFFENBERGER
IPC: H04L9/30
Filed: 2010-07-31
Granted: 2015-11-24
Abstract: Cette invention se rapporte à un composant de réseau qui comprend au moins un processeur couplé à une mémoire et conçu pour échanger des informations de sécurité à l'aide d'une pluralité d'attributs dans une entité de gestion (ME) dans une unité de réseau optique (ONU) par l'intermédiaire d'un canal d'interface de commande de gestion d'ONU (OMCI), la ME prenant en charge une pluralité de fonctions de sécurité qui protègent les transmissions amont entre l'ONU et un terminal de ligne optique (OLT). Est également inclus un appareil qui comprend une ONU conçue pour se coupler à un OLT et qui comprend une ME OMCI, la ME OMCI comprenant une pluralité d?attributs qui prennent en charge une pluralité de caractéristiques de sécurité des transmissions amont entre l'ONU et l'OLT, et les attributs communiquant par l'intermédiaire d'un canal OMCI entre l'ONU et l'OLT et fournissant les caractéristiques de sécurité de l'ONU et de l'OLT.