baber/WOPTO huggingface dataset:
Patent DE-60330595-D1 (DE)
Inventor: MATSUSHIMA KOUJI
IPC: A61K35/15
Filed: 2003-10-21
Granted: 2010-01-28
Abstract: Although the fields of therapeutic applications of dendritic cells are now expanding, dendritic cell precursors exist only in a small amount in the peripheral blood and, therefore, it is still difficult to obtain them in a therapeutically useful amount even though they are proliferated in vitro. Therefore, it is a key point in performing a therapy with the use of dendritic cells in practice to elevate dendritic cell precursor level in the peripheral blood of a patient. <??>The present invention provides an agent for elevating dendritic cell precursor level in the blood which comprises an agonist to a receptor expressed in immature dendritic cells or a functional derivative thereof as the active ingredient. <IMAGE>
Patent DE-68904342-D1 (DE)
Inventor: MATASSA VICTOR GIULIO
IPC: C07D401/06
Filed: 1989-04-12
Granted: 1993-02-25
Abstract: This invention provides a series of novel cyclic amides of formula I in which the group >Z-Y-X< is selected from >C=CH-N<, >N-CH=CX<, >C=N-N< and >N-N=C< and the other radicals have the meanings defined in the following specification. The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.
Patent DE-68912797-D1 (DE)
Inventor: COMMANDEUR RAYMOND
IPC: C07C303/38
Filed: 1989-03-07
Granted: 1994-03-17
Abstract: Process for the synthesis of arylsulphonylalkylamides in which an arylsulphonyl halide is placed in contact with an excess of alkylamine and an aqueous solution of alkaline agent in excess in relation to the arylsulphonyl halide and then the water and excess amine are removed from the organic phase; the arylsulphonylalkylamide is then isolated. This process is particularly suited for N-n-butylbenzenesulphonamide which is obtained in a thermally stable quality and which can be advantageously employed as a plasticiser for polyamides.
Patent DE-68919433-D1 (DE)
Inventor: ACTON DAVID GORDON
IPC: C07D501/38
Filed: 1989-05-05
Granted: 1995-01-05
Abstract: Cephalosporin antibiotics having a 3-position substituent of the formula: <CHEM> are described; wherein R<1> is hydrogen or certain substituted alkyl groups, Z is CH or N, R<2> and R<3> are hydroxy or in vivo hydrolysable esters thereof, (R<1><2>)n represents various optional substituents and X = Y is an olefin, oxime, azo or related group. Processes for their preparation and use are described.
Patent DE-68925044-D1 (DE)
Inventor: NYGREN PER-AKE
IPC: C12R1/44
Filed: 1989-02-02
Granted: 1996-01-25
Abstract: A method of producing a fusion protein or polypeptide capable of selective bindning to serum albumin, characterized by the steps:   a) constructing a recombinant vector comprising a first DNA sequence coding for a serum albumin binding polypeptide fragment and operatively linked to a second DNA sequence coding for a desired protein or polypeptide; b) transforming a compatible host with said recombinant vector such that the combined DNA sequence coding for said fusion protein or polypeptide can be expressed by the host, and culturing the transformed host in a suitable growth medium to produce said fusion protein or polypeptide; and   c) isolating said fusion protein or polypeptide;  a recombinant vector capable of replication in a microorganism;  a host organism transformed by such recombinant vector; and fusion proteins or polypeptides produced according to such method.
Patent DE-69003500-D1 (DE)
Inventor: HARRINGTON DAVID
IPC: F16L55/26
Filed: 1990-04-09
Granted: 1993-10-28
Abstract: A method of repairing a pipeline and apparatus for use in such a method is disclosed where a sheet like repair material is set in position within the pipeline with the use of a settable substance, the repair material being carried into the pipeline on a core member (4) the carries an inflatable member, the inflatable member (1) extending axially along the core member (4) and at least partially around the core member (4) to define an annular or part annular enclosed space (9,10) extending along the core member (4), means (8,11) being provided to inflate or deflate the inflatable member when in position in the pipeline, the inflatable member further having an outer flexible surface portion fixed only at one axial end to the core member, the inflatable member (1) acting when inflated to press the repair material against the pipeline wall to be repaired with the inflatable member (1) being thereafter deflated with the apparatus being withdrawn from the pipeline in a direction whereby the outer wall portion of the inflatable member (1) is progressively everted and peeled away from the repair material.
Patent DE-69005451-D1 (DE)
Inventor: LEHRMAN SHERWOOD
IPC: C12R1/19
Filed: 1990-06-27
Granted: 1994-02-03
Abstract: The present invention provides analogs of animal somatotropins particularly with changes in the amino acids between residue 96 to 133 which are changed to reduce hydrophobicity or helical stability.
Patent DE-69006701-D1 (DE)
Inventor: DIERICKX PATRIECK
IPC: F16L9/12
Filed: 1990-06-29
Granted: 1994-03-24
Abstract: Composite plastic pipe, characterized in that it principally consists in the combination of an extruded pipe in thermoplastic synthetic material and a pultruded pipe or pipe obtained by pull winding in thermoplastic or preferably thermo-hardening synthetic material which fit closely.
Patent DE-69010496-D1 (DE)
Inventor: SLIWA MICHAEL
IPC: B65C9/08
Filed: 1990-05-16
Granted: 1994-08-11
Abstract: Apparatus for transferring foil from a carrier tape (48) to a moving web (2) comprising a rotatable cylinder (17) including at least one die (51). The web is traversed around the cylinder. A transport mechanism (42, 49) which is rotatable with the cylinder indexes the tape generally lengthwise of the cylinder and over the position of the die. The tape travels along a guide (59) in the cylinder. Where the tape passes over the position of the die a roller or band presses the web against the tape and the die.
Patent DE-69010729-D1 (DE)
Inventor: ANDREOLI ROVATI ROMEO
IPC: C07D233/56
Filed: 1990-04-04
Granted: 1994-08-25
Abstract: Dichloro-substituted 1-(5H-dibenzo[a,d]cyclohepten-5-yl)-1H-imidazole compounds of formula (I), in which -X- is either -CH2-CH2- or -CH=CH-, and their pharmaceutically acceptable addition salts, preferably the nitric acid ones. Products of formula (I) are prepared from products of formula (VI) where Z represents a leaving group such as halogen, by treatment with an excess of imidazole in dimethylformamide. Products (I) show an antifungal activity comparable -or superior- to antimycotics in the market, such as Clotrimazole and Bifonazole. <CHEM> [
Patent DE-69010876-D1 (DE)
Inventor: JOHNSON WILLIAM B
IPC: A61C5/04
Filed: 1990-01-09
Granted: 1994-08-25
Abstract: An improved appliance for use in applying filler material, such as gutta-percha or the like, to an endodontically prepared root canal of a tooth in the form of an elongated shaft (12) of material having high biological tolerance, the shaft having a handle portion (26) at the proximal end portion (40), the shaft distal end portion (42) having a surface configuration adaptable to retain filler material formed thereon and being positionable in a root canal, the shaft distal and proximal portion being severable from each other whereby the distal portion and filler material therein remain in the root canal. In the preferred arrangement the shaft distal portion surface is defined by a spiral groove (44).
Patent DE-69017204-D1 (DE)
Inventor: COLLINS MARK
IPC: C12Q1/68
Filed: 1990-03-06
Granted: 1995-03-30
Abstract: The invention is a method of detecting nucleic acids in a sample using oligonucleotide probes which are noncovalently bound to solid supports for rapid, sensitive, hybridization assays. The method involves coating the support surface with a polynucleotide and then hybridizing a specific capture probe for each analyte to the polynucleotide by way of a short tail of the complementary polynucleotide. The immobilized probes are used to capture nucleic acid targets out of complex specimens for nonisotopic detection without the need for prior cell culture or purification of the target nucleic acids. A panel of tests can be run on each specimen simultaneously, a format that conserves precious samples. The assay can be readily automated, and can be conveniently run in a manual fashion on large numbers of samples in two to three hours.
Patent DE-69023682-D1 (DE)
Inventor: MEHRA DEV K
IPC: A61K9/16
Filed: 1990-03-22
Granted: 1996-01-04
Abstract: Freeze-dried polymer latices, which can be reconstituted in water to give aqueous polymer dispersions having high polymer solids content, are described. The reconstituted polymer dispersions are useful in preparing sustained-release drug formulations, particularly of water-soluble drugs, by the wet granulation method without over wetting.
Patent DE-69028316-D1 (DE)
Inventor: CHENG DAH YU
IPC: G02B5/10
Filed: 1990-12-20
Granted: 1996-10-02
Abstract: An Orthogonal Parabolic Reflector is generated by rotating a parabolic curve 90 DEG  to the axis of symmetry passing through the focal point of the parabola. The Orthogonal Parabolic Reflector can concentrate a section of the linear source or sink on the axis of rotation to the focal point, resulting in integrating the intensity as a point source or sink at the focal point with almost no physical dimension effects.
Patent DE-69028797-D1 (DE)
Inventor: HENRICSON HENRICSON
IPC: B01D19/00
Filed: 1990-03-20
Granted: 1996-11-14
Abstract: The present invention relates to a method of bleaching cellulose pulp with ozone. Ozone bleaching has been extensively studied in laboratory and pilot scale. It has been proved that at low consistencies, i.e. less than 5 %, ozone dissolves well in water and thus good transfer of substance between the ozone and the fibers in the water is achieved. On the other hand, it has been discovered that the ozone, being a gaseous substance, reacts well also directly with a fiber surface which, however, presupposes that the consistency of the suspension is over 25 %. Further, it has been discovered that in the intermediate range between said consistencies ozone cannot satisfactorily contact the fibers. However, both environmental and pumping factors determine the operation to be carried out at that particular intermediate consistency range of 5 to 25 %. A characteristic feature of the method of the present invention, which avoids the disadvantages of prior art methods and permits operation at the consistency range of 5 to 25 %, is that cellulose pulp is pumped with a high-consistency pump to a fluidizing mixer in which O2/O3 gas is introduced and mixed into the pulp so as to generate foam in which the fibers in the pulp and the ozone used as the bleaching agent are brought to contact with each other, and that the pulp is discharged from the mixer to a reaction vessel.
Patent DE-69032435-D1 (DE)
Inventor: INSTANCE DAVID JOHN
IPC: G09F3/02
Filed: 1990-09-28
Granted: 1998-07-23
Abstract: A method of producing a succession of self-adhesive labels on a length of a release material, the method comprising the steps of: (a) die-cutting a length of pressure-sensitive stock to provide a succession of self-adhesive supports which are coated on their rear surface with a pressure-sensitive adhesive and which are releasably adhered to a length of release material (2); (b) disposing a respective succession of multilaminar label pieces (10) over the self-adhesive supports and adhering a length of laminar material (14) over the multilaminar label pieces and the self-adhesive supports and to the release material between adjacent self-adhesive supports; and (c) die-cutting (18) through the length of laminar material as far as the release material thereby to form a succession of self-adhesive labels (20) on the release material, each self-adhesive label including a multilaminar label piece carried on a respective self-adhesive support and a portion of the laminar material thereover.
Patent DE-69033560-D1 (DE)
Inventor: LARNER JOSEPH
IPC: A23L1/09
Filed: 1990-03-08
Granted: 2000-07-06
Abstract: A dietary supplement for the therapeutic treatment of those exhibiting clinical symptoms of insulin-resistant type II diabetes, and preventing the development of clinical symptoms in those genetically predisposed to the development of such symptoms, is provided by the administration of a dietary supplement comprising D-chiro-inositol. The dietary supplement is preferably administered orally, in vitamin-like amounts.
Patent DE-69033982-D1 (DE)
Inventor: STETLER-STEVENSON G
IPC: G01N33/573
Filed: 1990-03-21
Granted: 2002-08-01
Abstract: The present invention is an isolated protein of 21,600 Da which binds to both latent and activated type IV collagenase with high affinity at 1:1 molar stoichiometry, thereby abolishing enzyme activity. The protein is purified by affinity chromatography on solid phase metalloproteinase, or solid phase metalloproteinase substrates which bind the enzyme-inhibitor complex. The complete primary structure of this protein (initially called CSC-21K), as determined by sequencing overlapping peptides spanning the entire protein, reveals homology with a protein called TIMP, Tissue Inhibitor of Metalloproteinases. In addition, a cDNA for this novel inhibitor, now designated TIMP-2, was cloned from a melanoma cell and its sequence was compared with that of human TIMP-1. Northern blots of melanoma cell mRNA showed two distinct transcripts of 0.9 kb and 3.5 kb which are down-regulated by transforming growth factor- beta , and are unchanged by phorbol ester treatment. The inhibitor of the present invention may be used for treatment of pathologic conditions resulting from inappropriate degradation of extracellular matrix molecules by matrix metalloproteinases, such as metastatic neoplasia, myocardial infarction, and arthritis. Therapeutic treatments using this inhibitor may include formulations for inhalation and inclusion complexes adapted for buccal or sublingual administration, or administration of a recombinant DNA molecule which expresses a DNA segment that encodes the matrix metalloproteinase inhibitor of this invention.
Patent DE-69108381-D1 (DE)
Inventor: WEBER GUENTER
IPC: G03B42/02
Filed: 1991-11-15
Granted: 1995-04-27
Abstract: PCT No. PCT/EP91/02154 Sec. 371 Date Jul. 2, 1992 Sec. 102(e) Date Jul. 2, 1992 PCT Filed Nov. 15, 1991 PCT Pub. No. WO88/09523 PCT Pub. Date Dec. 1, 1988.The device is arranged in the form of a complete assembly group on two plates (1,2) screwed together by spacer bolts (18). Guide slots (1a,1b,2a,2b) of similar arrangement and design serve for positively guiding a reciprocable carriage (9,10). The carriage (9,10) comprises a guide member (9) with guide rollers (12,13,33,34) which are supported on ball bearings, bars (3,4) being hinged to the guide member which at their other ends are hinged to drivers (5,6). The drivers (5) are secured to toothed belts (7,8) guided and driven by gear wheels (16,30) mounted on the plates. A carrier (10) is mounted on the guide member (9) so as to be shiftable, liftable and tiltable and supports a pivotally mounted suction plate (11,22). The guide slots are arranged in a position inclined towards the cassette (27) to be unloaded while the toothed belts (7,8) are arranged in an angular position opening in this direction. The guide slots (1b,2b) facing the cassette (27) have in their lower end areas downwardly bent guide sections (1d,2i) which in connection with the angular arrangement of the toothed belt (7,8) cause the suction members (22) to be slowed down when being lowered onto the film (30) to be unloaded.
Patent DE-69108554-D1 (DE)
Inventor: SUNDREHAGEN ERLING
IPC: G01N30/06
Filed: 1991-06-20
Granted: 1995-05-04
Abstract: PCT No. PCT/EP91/01145 Sec. 371 Date Feb. 19, 1993 Sec. 102(e) Date Feb. 19, 1993 PCT Filed Jun. 20, 1991 PCT Pub. No. WO91/19993 PCT Pub. Date Dec. 26, 1991.The present invention provides a method of assessment of the concentration of a subset of variants in a population of proteinaceous analyte variants capable of separation by a fractionation system, wherein said population of variants are contacted with a population of labelled proteinaceous specific binding partners therefor to form labelled binding partner-analyte complexes therewith, which are then subjected to separation by the said fractionation system into one or more fractions containing said subset of analyte variants in complexed form and assessment of the amount of label in one or more fractions so obtained, the said population of specific binding partners having, prior to reaction, substantially uniform distribution or mobility in said fractionation system, compositions and test kits for use in such methods. The method of the invention is particularly suitable for the analysis of variants of the protein transferrin.
Patent DE-69109298-D1 (DE)
Inventor: GLAZENBURG KOENRAAD
IPC: C12N15/869
Filed: 1991-08-15
Granted: 1995-06-01
Abstract: The invention relates to a microorganism having a modified cell, tissue or host tropism whereby at least one gene of the microorganism, preferably an essential gene, is brought under the control of a nucleotide sequence specific for the cell, the tissue or the host. The specific nucleotide sequence can be a promoter sequence and/or enhancer sequence, which can be inducible. The invention is also directed at the use of such a recombinant microorganism for the provision of protection against the corresponding natural microorganism.
Patent DE-69114032-D1 (DE)
Inventor: GAVAGNA LIBERO
IPC: B65H75/44
Filed: 1991-02-18
Granted: 1995-11-30
Abstract: There is described a device for operating flexible elements (15, 16) essentially made up of a rotating drum (3) around which are wound flexible elements (15, 16) to be advanced, a container (2) of the drum equipped with a series of rubber rollers (6) which hold said flexible elements (15, 16) in adherence with the outer surface of the drum and which has a longitudinal slot which permits passage of the flexible elements (15, 16) from the inside to the outside of the container (2), a moving guide (14) for said flexible elements (15, 16) positioned across the drum (3) and which moves with reciprocating movement and facilitates winding or unwinding of the flexible element (15, 16) on or from the drum (3). <IMAGE>
Patent DE-69121849-D1 (DE)
Inventor: SHIGEKAWA BRIAN LAYNE
IPC: G01N33/58
Filed: 1991-12-01
Granted: 1996-10-10
Abstract: Gold sol coated with alkanethiols and alkanethiol derivatives, which provide groups on the sol available for the linking of binding moieties such as antibodies, antigens or ligands to the gold sol. Di- and tri-thiol compounds bound to gold sol also facilitate the adsorption of antibodies, antigens or ligands to the sol. The coating process, and test kits incorporating the coated sols are also included.
Patent DE-69200299-D1 (DE)
Inventor: GILSON JEAN-MARC
IPC: C08G77/08
Filed: 1992-06-30
Granted: 1994-09-08
Abstract: A continuous static polymerisation reactor for the production of liquid polymers comprises an elongated hollow reaction chamber (30) which has a porous wall (31) and a jacket means (40) spaced around the reaction chamber (30), which is provided with means (44) for introducing a fluid through the porous wall (31). The reactor is particularly useful for a process for making liquid polymers by condensing monomers and/or oligomers. It comprising the use of a pressurised gas to cause the reaction mixture to reach a foam-like consistency. This is beneficial in the condensation polymerisation. Feeding a fluid through the porous wall into the reaction chamber avoids build up of the polymer on the wall. <IMAGE>
Patent DE-69201500-D1 (DE)
Inventor: HERRINGTON FOX JOHN
IPC: A44B19/16
Filed: 1992-03-05
Granted: 1995-04-06
Abstract: A fastener structure for a thermoplastic bag, comprising a pair of flexible plastic strips (14,15) adapted to be secured to the facing sidewalls along the mouth of a thermoplastic bag; reclosable interlocking male and female profile elements on the respective strips; and a slider (10) straddling the strips for opening or closing the male and female profile elements. The structure also includes end clamp means (30) located at the opposite ends of said strips (14,15), each of said end clamp means (30) comprising a pair of clamp members positioned, in use, on opposite sides of the bag for clamping the pair of strips and the facing sidewalls of the bag therebetween. Means (30a,30b) is provided for clamping each of said pair of clamp members together to provide a seal at the ends of said strips, said end clamp means providing a stop surface adapted to engage with the slider for preventing the slider from moving past the ends of the strips. A method of manufacturing a plurality of thermoplastic bags incorporating a fastener structure is also disclosed. <IMAGE>
Patent DE-69204291-D1 (DE)
Inventor: KAPTEIJN FREEK
IPC: B01J23/34
Filed: 1992-07-17
Granted: 1995-09-28
Abstract: PCT No. PCT/GB92/01312 Sec. 371 Date Apr. 14, 1994 Sec. 102(e) Date Apr. 14, 1994 PCT Filed Jul. 17, 1992 PCT Pub. No. WO93/02776 PCT Pub. Date Feb. 18, 1993.A catalyst for the selective reduction of nitric oxide NO in flue gas to nitrogen using ammonia NH3 comprises oxidatively heat treated manganese oxide loaded on a porous substrate of gamma-alumina or titania- or titania-/WO3-modified silica.
Patent DE-69218858-D1 (DE)
Inventor: KURATA MITSURU
IPC: B41J13/14
Filed: 1992-09-02
Granted: 1997-05-15
Abstract: The present invention provides a sheet conveying apparatus comprising, sheet supply means for supplying a sheet, guide means for guiding said sheet delivered by said sheet supply means, hold down member for pressing said sheet against said guide means, release means for releasing the pressure of said hold down member, and control means for controlling said sheet supply means in connection with the pressure releasing operation of said release means. <IMAGE>
Patent DE-69221400-D1 (DE)
Inventor: VAN DEN BRINK ROBERTUS FRANCIS
IPC: G01R31/26
Filed: 1992-06-10
Granted: 1997-09-11
Abstract: Method of determining a noise spectrum of an optical receiver comprising a detector and a preamplifier, in which, starting from a standardised light source, the output signal of said light source is presented to the input of the receiver and the equivalent noise spectrum of the optical receiver is compared with and expressed in the electrical response spectrum of the light source. If the light source has also to be standardised beforehand, this is done by comparing the electrical response spectrum of the light source with, and expressing it in, the noise spectrum of a known electrical noise source, for example a resistor. The method can be used, in particular, if the electrical input of the preamplifier is not accessible from outside, if the optical input of the receiver is accessible only via a glass fibre, if the noise contribution of the receiver is relatively large, if the receiver is very broadband, and if its sensitivity is unknown but also frequency-dependent. <IMAGE>
Patent DE-69221779-D1 (DE)
Inventor: ALFERNESS CLIFTON A
IPC: A61N1/32
Filed: 1992-06-03
Granted: 1997-10-02
Abstract: A cardiac pacing apparatus and method. A cardiac pacing apparatus (24) provides a cardiac pacing signal to a plurality of electrode pairs (20, 22), each comprising a positive electrode (20a, 22a) and a negative electrode (20b, 22b). A plurality of isolated current sources (30, 32) supply the electrode pairs with separate electric pacing currents, each small enough in magnitude so as to avoid patient discomfort or burning. The plurality of pacing currents delivered to the electrode pairs add to produce a total cardiac pacing current of sufficient magnitude to cause contraction of a heart muscle through which the pacing currents flow. <IMAGE>