baber/WOPTO huggingface dataset:
Patent EA-004742-B1 (EA)
Title: Method for the preparation of citalopram
Inventor: PETERSEN HANS
IPC: C07C213/00
Filed: 1999-12-28
Abstract: 1. A method for the preparation of citalopram or any of its enantiomers and acid addition salts thereof comprising reaction of a compound of formula with a) a diene having the formula wherein X is O, S, SO2, -N=N-, -CO-O-, or -O-CO-; followed by oxidation to form citalopram; or with b) a compound of formula wherein R is alkyl or optionally substituted aryl or arylalkyl, followed by conversion of the resulting compound of formula wherein R is as defined above, to a compound of formula which is converted to a compound of formula followed by oxidation of the compound of formula VII to form citalopram; and thereafter optionally converting the free base or an acid addition salt of citalopram, thus obtained, to a pharmaceutically acceptable salt thereof. 2. The method according to claim 1 characterized in that the compound of formula II is prepared by i) reaction of a 4-fluorobenzoic acid derivative of the formula wherein Y is halogen, especially chloro, -O-alkyl, -NR'R" wherein R' and R" are selected from hydrogen, alkyl, alkoxy or R' and R" together form a ring, with M<+>, -<+>C [triple bond] C-CH2-O-Z, wherein M<+> is a metal ion and Z is a protection group or hydrogen, followed by removal of the protecting group Z; and ii) reaction of the resulting compound of formula IX with a Grignard reagent having the formula HalMg(CH2)3NMe2 wherein Hal is chloro or bromo; iii) reduction of the resulting compound of formula to form a compound of formula which is treated as a dehydrating agent to form a compound of formula II. 3. The method according to claim 1 characterized in that the compound of formula II is prepared by vi) reaction of 4-fluorobenzaldehyde of the formula of the formula XII with M<+>, <+>C [triple bond] C-CH2-O-Z, wherein M<+> is a metal ion and Z is a protection group or hydrogen; v) oxidation of the resulting compound of formula XIII and removal of the protecting group Z to form a compound of formula IX vi) reaction of the compound of formula IX with a Grignard reagent having the formula HalMg(CH2)3NMe2 wherein Hal is chloro or bromo; vii) reduction of the resulting compound of formula to form a compound of formula which is treated with a dehydrating agent to form a compound of formula II. 4. The method according to claim 1 characterized in that the compound of formula II is prepared by viii) reaction of a compound of formula with a Grignard reagent having the formula HalMgCCCH2OmgHal, wherein Hal is chloro or bromo; vix) reduction of the resulting compound of formula to form a compound of formula which is treated with a dehydrating agent to form a compound of formula II. 5. The method according to claim 1wherein the compound II is used in the form of the S-enantiomer.
Patent EA-013052-B1 (EA)
Title: Medical preparation
Inventor: RESHETOV ALEXANDER LEONIDOVICH
IPC: A61K31/513
Filed: 2004-03-26
Abstract: The invention relates to a medicinal preparation containing an active agent and target additives, wherein the active agent contains (2,4-dihydroxyl-6-methyl-5-pyrimidyl)-(4-pyridin-carbonyl-hydrazinyl) sulphon of formula (III) or the efficient quantity of pharmaceutically acceptable salts and isomers thereof. In addition, the inventive medicinal preparation can contain at least one type of antituberculous remedy such as isoniozid, rephampicine and pyrazinamide. Said preparation can be embodied in the form of pills, capsules, syrup and injections.
Patent EA-011779-B1 (EA)
Title: Underground and partly submerged pipe winding apparatus and method
Inventor: BATEMAN IAN ROGER
IPC: B29C63/32
Filed: 2006-04-10
Abstract: An apparatus and method for lining an underground conduit is disclosed. The apparatus (10) comprises: an annular frame (40) having a crown portion (42) and a base portion (49); a strip guide disposed around and supported by the annular frame (40), the guide arranged to guide a strip (12) around a helical path; a pair of strip pinch rollers mounted to the frame (40) at a position circumferentially about halfway between the crown portion (42) and the base portion (49); a drive assembly mounted to the frame for driving the strip (12) downwards into the helical path in a winding direction so as to present an incoming first edge to an adjacent second edge of a wound convolution of the strip; a liquid remover mounted to the frame, the liquid remover arranged to prevent liquid that has adhered to and ascended with the second edge from descending down towards the incoming first edge; ; and an extruder (80) mounted to the frame (40) for extruding a molten bead of plastic onto the strip (12) at a position just before said overlap.
Patent EA-013095-B1 (EA)
Title: Sealing device
Inventor: GAIDUK VALERII FEDOROVICH
IPC: F16J15/18
Filed: 2008-06-05
Abstract: The invention relates to a sealing technique, to be more precise - to the gland seal of moving joints of reciprocating and rotary type, and can be used for sealing of shafts, rods and plungers in the energy, metallurgical, chemical and petroleum industries. The sealing device consists of an immovable housing and installed in the housing with the ability to move in the radial and axial directions stuffing box with packing covering the sealing surface, and fitted with a console. The root of the console is connected to the housing through the elastic supports, and the free end of the console is connected via the elastic supports with the stuffing box. In the position of joint of the stuffing box and the housing additionally at least three balls are placed with the possibility of rolling on the bearing surfaces both of the housing and stuffing box. The spherical bearings can be separated from each other by partitions made on the bearing surface of the housing or stuffing box. In addition, spherical bearings can be connected to each other via a separator, installed between the bearing surfaces of the housing and stuffing boxes. Finally, spherical bearings can be placed between two flanges, one of which via a flexible support connected to the housing, and the other - with the stuffing box. Such a sealing device has a high radial movability of the stuffing box, which ensures reliable and long-term operation of the device even at large radial vibrations of the shaft and high pressure of working medium.
Patent EA-011852-B1 (EA)
Title: Key duplication method and machine
Inventor: HADAD YVAN
IPC: B23C3/35
Filed: 2007-02-07
Abstract: A method for duplicating a key including receiving a key identification code indicative of key cuts in an original key, and duplicating the original key by forming key cuts in a duplicate key in response to the key identification code, wherein authorization to form the key cuts is restricted by means of a verification code that must be passed before forming the key cuts is permissible. The authorization to form the key cuts may be restricted in various ways, such as to a group of users, a geographic location of a user, or a group of key blanks. The authorization to form the key cuts may be restricted as a function of a physical characteristic of the original key. As another alternative, authorization to form the key cuts may be restricted as a function of whether the original key is a master key or a slave key.
Patent EA-012152-B1 (EA)
Title: Opening method of useful mineral flat formation
Inventor: SMYCHNIK ANATOLY DANILOVICH
IPC: E21C41/16
Filed: 2008-08-04
Abstract: The invention concerns the mining, in particular the underground development of useful mineral of the flat seam on the deep depth and can be used in the development of Gremyachensky deposit of potash salt (Kotelnikovsky region Volgograd district). The object of the present invention is to increase the efficiency of the useful minerals development of the underground method due to the term decrease and expenses on the excavation of useful mineral of the flat formation. The solution to this task is reached by the way that during the underground development in the method of the opening of useful mineral of the flat formation the deep depth and unstable ground granting in bottom of formation, for example), including deepening of vertical shaft (skip and cage) till the surface of the seam, workings of the shaft inset are situated in the standing ground of the top of bed, storage hopper- upper of the shaft inset and the cell on the calculation value, sump part of each mine shaft, including loading and measuring installation of skip shaft- on the calculated distance lower than the low mark of the shaft inset. And the immediate opening of the seam of the useful minerals is hold by the transport and ventilation deep, leaded from the working outs of the shaft inset along of the inclination of the seam and situated within the guarded high pillar. The distance from the vacuity of the seam until the level of the shaft inset is calculated by the formula:H = (B+B)(tgα– tgα),Where: B- width of the safety berm, m; B- width of the safety pillar, m; α- the angle of the opening seam; α- the angle of the transport and ventilation deep.
Patent EA-013297-B1 (EA)
Title: Directly driving high current load switch and controlling system therefor
Inventor: LIANG XUEMIN
IPC: H01H89/00
Filed: 2007-07-31
Abstract: A directly driving high current load switch, a stationary contact is mounted on a back fixed plate of a frame (2), an electromagnetic operating device (10) is mounted between a middle fixed plate and a front fixed plate of the frame (2). A front end of a driving level of the electromagnetic operating device (10) runs through the front fixed plate of the frame (2) and is connected to a front end of a driving connecting level (14) by lever-type configuration. The driving connecting level (14) runs through and is mounted on the middle fixed plate and the front fixed plate, a back end of which is connected to a movable contact (3). The movable contact (3) is connected to a movable contact wiring terminal mounted on the back fixed plate of the frame (2) by a flexible conductor (6). In a directly driving high current load switch controlling system, synchronized operating of the directly driving high current load switch can be realized by PLC.
Patent EA-021282-B1 (EA)
Title: DIMERIC AND/OR OLIGOMERIC FORMS OF HUMAN ApoA-1 PROTEIN MUTEIN PRODUCED IN PLANT SEEDS AND USE THEREOF
Inventor: FOGHER CORRADO
IPC: C12N15/82
Filed: 2006-12-19
Abstract: The present invention encompasses a method for the production of human ApoA-1 protein muteins in dimeric and/or oligomeric forms (comprising three or more units) in plant seeds, novel variants of these proteins having an increased stability and capacity to transport cholesterol compared to the native ApoA-1 protein. The invention also relates to an expression system of said mutein, plants transformed capable of producing said mutein in seeds in dimeric and/or oligomeric forms, and nutraceutical derivatives, comprising said mutein.
Patent EA-020148-B1 (EA)
Title: Solid dosage form having a choleretic effect (variants)
Inventor: CHELYAEVA ANASTASIYA GENNADIEVNA
IPC: A61K9/20
Filed: 2012-10-04
Abstract: The invention relates to the pharmaceutical industry and medicine and can be used in the creation and administration of solid dosage forms having a choleretic effect. The present invention is aimed at creating an effective solid dosage form having a choleretic effect. In the description, two variants of the invention are claimed which solve the problem of interest in that the solid dosage form contains dried bile, mineral substances and a pharmaceutically acceptable carbon-containing additional substance with carbonC isotopes. The invention achieves the technical results of a greater and more rapid therapeutic effect in the treatment of liver and gall bladder diseases without decreasing the duration of said therapeutic effect or increasing the concentration of bile.
Patent EA-030549-B1 (EA)
Title: Method for controlling aluminum electrolyzer on the basis of minimum power
Inventor: BORZYKH SERGEY DMITRIEVICH
IPC: C25C3/20
Filed: 2015-08-31
Abstract: The invention relates to aluminum metallurgy, and specifically to a method for producing aluminum via the electrolysis of molten salts, and particularly to a method for controlling an aluminum electrolyzer on the basis of minimum power. The method consists in measuring a voltage drop across the resistance of an electrolyzer, comparing the measured value with a set value for a voltage drop in an electrolyzer, and eliminating any discrepancy by correspondingly displacing an anode. Displacing the anode allows for reducing the discrepancy between the heating power and a set value until the electrolyzer outputs a minimum power. The minimum power output is determined in accordance with the spontaneous growth of an electrochemical component of the electolyzer voltage, and a given discrepancy is maintained by correspondingly displacing the anode without changing the heat state of the electrolyzer. The invention allows for reducing electrical energy consumption, increasing current metal yield, and decreasing the labor-intensity of maintenance of electrolyzers.
Patent EA-026061-B1 (EA)
Title: Freezer and method of its operation
Inventor: DIKS-WARMERDAM LEONIE MARTINE
IPC: A23G9/22
Filed: 2013-08-28
Abstract: A freezer for storing frozen confectionery products, the freezer comprising a substantially sealed openable chamber for storing the frozen confectionery products and having a lower region and an upper region, the lower region comprising air circulation means for directing air from the lower region to the upper region and refrigeration means for chilling the chamber.
Patent EA-035882-B1 (EA)
Title: Antisense oligonucleotides inducing exon skipping for treating muscular dystrophy
Inventor: BESTWICK RICHARD K
IPC: A61K31/7088
Filed: 2014-03-14
Abstract: Antisense molecules capable of binding to a selected target site in the human dystrophin gene to induce exon 44 skipping are described.
Patent EA-031145-B1 (EA)
Title: Double-disc ploughshare comprising an innerlying depth guide
Inventor: BERENDSEN MARK
IPC: A01C7/20
Filed: 2014-10-15
Abstract: At least one set of a double-disc ploughshare (7, 8) and one depth-guide roller (9) are arranged in each case on the frame (6) of a pneumatic precision seeder. Said depth-guide roller (9) is arranged between the two disc ploughshares (7, 8) when viewed in the direction of travel, wherein both ploughshares (7, 8) and the depth-guide roller (9) rotate in the same direction.
Patent EA-034708-B1 (EA)
Title: 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
Inventor: SASIKUMAR POTTAYIL GOVINDAN NAIR
IPC: A61K31/00
Filed: 2016-03-07
Abstract: The present invention relates to 1,2,4-oxadiazole and thiadiazole compounds of formula (I) and their use for inhibiting the programmed cell death 1 (PD1) signaling pathway and/or for treating disorders by inhibiting an immunosuppressive signal induced by PD-1, PD-L1 or PD-L2.
Patent EA-035379-B1 (EA)
Title: Energy saving greenhouse screen
Inventor: HOLGERSON PER
IPC: A01G9/22
Filed: 2017-05-30
Abstract: A greenhouse screen comprising strips (11) of film material that are interconnected by a yarn system of transverse threads (12, 14, 18) and longitudinal threads (13a, 13b; 15; 19) by means of knitting, warp-knitting or weaving process to form a continuous product, wherein at least some of the strips (11) comprise a film material in the form of a single- or multilayer polyester film is disclosed. The film material has a transparency of at least 93.5% and is provided with at least a first anti-reflective coating or layer on a first side of the film material.
Patent EA-038184-B1 (EA)
Title: Spectrophotometer
Inventor: KRIVETSKY KONSTANTIN NIKOLAEVICH
IPC: G01J3/427
Filed: 2019-01-14
Abstract: The invention is related to the field of optical instrument engineering and intended for use in analyses in factory laboratories and for research purposes in analytical studies of spectral characteristics of various materials. The technical result: improvement of quality and accuracy of angular measurements and the measurements of complicated prisms.
Patent ES-2177388-B1 (ES)
Title: Procedimiento para la fabricacion de articulos carnicos y articulo carnico obtenido.
Inventor: RISTOL UBACH MIGUEL
IPC: A23L13/40
Filed: 2000-04-07
Granted: 2003-11-01
Abstract: Procedimiento para la fabricación de artículos cárnicos y artículo cárnico obtenido. El procedimiento comprende la disposición en el interior de una masa de carne picada de una porción de salsa solidificada a temperatura ambiente, separada con respecto a las caras externas de la masa de carne picada y susceptible de licuarse en el calentamiento de la pieza de carne para su consumo. La porción de salsa adopta la estructura de una pieza única aplanada dispuesta con una separación regular con respecto a la periferia de la pieza de carne picada y asimismo con respecto a sus caras superior e inferior.
Patent ES-2187246-B1 (ES)
Title: Sistema de hidrocultivo de germinados por conformacion.
Inventor: SANTOS ALONSO RAFAEL
IPC: A01G24/60
Filed: 2000-08-08
Granted: 2004-08-01
Abstract: Sistema de hidrocultivo de germinados por conformación, que comprende la hidratación de semillas en tolvas de germinación (1), alternando ciclos de aireación y remojo, siendo luego introducidas en moldes (2), donde predomina la verticalidad y la germinación se produce a presión, las semillas retenidas por el molde (2), que a la vez permite que se expansionen. Una vez que las semillas se traban y son autoportantes, se retiran los moldes (2). El sistema se automatiza por una superficie portante perforada en los moldes con las semillas, siendo el conjunto (3) introducido en los canales de cultivo (4). El sistema se estructura sobre módulos que se dispondrán dentro de canales, uno por cada día de ciclo de cultivo y de longitudes variables según las producciones a obtener. El proceso se completa con la ayuda de puentes grúas, instalaciones (10) de lavado de moldes (2) y una mezcladora (9), finalizando el proceso con una cinta transportadora (11).
Patent ES-2168987-B1 (ES)
Title: Maquina dispensadora mejorada
Inventor: RODRIGO GARCIA ALEJANDRO
IPC: G07F11/00
Filed: 2000-09-29
Granted: 2003-11-16
Abstract: Máquina dispensadora mejorada. Cuenta con una unidad de dispensación (1) que expende automáticamente productos tales como tabaco, bollería u otros. Dicha unidad de dispensación (1) conecta con una unidad de juego (2) que permite apostar opcionalmente el correspondiente dinero a devolver o parte del mismo en la obtención de un premio, conectando ambas unidades (1 y 2) con un interfaz de usuario (3) y con un bloque de gestión de monedas (4); de manera que el usuario tras obtener el producto dispensado y en caso de estar pendiente de cierto dinero a devolver, puede elegir entre que le sea devuelto dicho dinero y entre que dicho dinero o parte del mismo sea apostado en la unidad de juego (2).
Patent ES-2179756-B1 (ES)
Title: Procedimiento de obtencion de azaeritromicina.
Inventor: ASENSIO DOMINGUEZ RAMON
IPC: C07H17/08
Filed: 2000-11-30
Granted: 2004-10-01
Abstract: "Procedimiento de obtención de azaeritromicina". El objeto de la presente invención es un procedimiento que permite obtener azaeritromicina de fórmula I, a partir de 6,9-iminoéter de la eritromicina A, que es reducido catalíticamente a baja presión (menos de 5 bares), tras un ajuste de pH con un ácido apropiado y utilizando como disolventes alcoholes de 1-3 átomos de carbono o mezclas de éstos con agua. En las condiciones adecuadas se obtiene una azaeritromicina de alta pureza con un buen rendimiento.
Patent ES-2213427-B1 (ES)
Title: Sistema de soporte y sujecion para lectura de libros, con sujeta-paginas, ajustable a distintos tamaños de libro y distintas posiciones de lectura.
IPC: B42D9/00
Filed: 2001-08-31
Granted: 2005-06-16
Abstract: Sistema de soporte y sujeción para lectura de libros, con sujeta- páginas, ajustable a distintos tamaños de libro y distintas posiciones de lectura, incluso en posición de lector tumbado boca arriba, permitiendo el paso de página de forma cómoda. El sistema consiste en hacer descansar los bordes de la portada y contraportada del libro abierto sobre unas estructuras elásticas (2) y fijar las páginas con sendos pisa-páginas (1) móviles de material transparente que podrán fijarse a diferentes distancias entre sí, así como a diferente altura sobre cada una de las estructuras elásticas, atrapando los bordes de las caras legibles del libro abierto entre ellos mismos y las estructuras elásticas. Incorpora también un elemento filiforme (3) para mejorar la sujeción del libro al atril. Posibilita a una persona tumbada leer con el libro suspendido por este sistema sobre su cabeza utilizando sus manos sólo para pasar las páginas.
Patent ES-2238115-B1 (ES)
Title: Nudo para estabilizador de estructuras de fachadas.
Inventor: DEL CASTILLO CABELLO EUGENIO
IPC: E04G7/30
Filed: 2002-11-06
Granted: 2006-11-01
Abstract: Nudo para estabilizador de estructuras de fachadas, que presenta como particularidad el hecho de que los nudos son solidarios con la propia estructura, estando compuesta dicha estructura por unos tramos horizontales, por unos verticales, unos tensores diagonales regulables, unidos a los nudos por unos adaptadores diagonales, y contando además con unos elementos de unión simples que permiten la unión entre tramos verticales contiguos, y unos elementos de unión dobles que permiten la unión entre tramos verticales adyacentes con los inmediatamente superiormente dispuestos a ellos.
Patent ES-2238120-B1 (ES)
Title: Dispositivo de sujecion de contenedores.
Inventor: GARCIA RUIZ DOMINGO
IPC: B62B5/04
Filed: 2002-11-13
Granted: 2006-10-16
Abstract: Dispositivo de sujeción de contenedores. Comprende un armazón anclado al suelo, provisto de un elemento de tope rígido adaptado para detener el desplazamiento del carro contenedor por apoyo contra una de sus paredes; un brazo retenedor articulado al armazón, destinado a pasar por debajo del carro contenedor y provisto en su extremo libre de un elemento de retención adaptado para retener a presión el carro contra el elemento de tope, mediante apoyo contra la pared del carro opuesta a la pared contigua al elemento de tope; y un elemento elástico que empuja al brazo retenedor articulado en sentido ascendente.
Patent ES-2211317-B1 (ES)
Title: Compuestos intermedios para la obtencion de principios activos antihipertensivos y procedimientos correspondientes.
Inventor: ARTUS SURROCA JUAN JOSE
IPC: C07D211/90
Filed: 2002-11-18
Granted: 2005-10-16
Abstract: Compuestos intermedios para la obtención de principios activos antihipertensivos y procedimientos correspondientes. El nuevo compuesto de fórmula general (II), donde R es metilo, fenilo ó 4- metilfenilo, se obtiene por reacción del cloruro de ácido sulfónico de fórmula CI-SO2-R con el correspondiente alcohol en un disolvente inerte. Mediante reacción de (II) con amoníaco se lleva acabo la sustitución del grupo sulfonato (-OSO2-R) por el grupo amonio (-NH3+). Del medio de reacción se pueden aislar sulfonatos de amlodipino farmacéuticamente aceptables (e.g. mesilato, besilato, tosilato) sin necesidad de aislar previamente el amlodipino, lo que conlleva importantes ventajas. Si, por el contrario, se basifica el medio de reacción, se puede aislar amlodipino (I) y transformarlo posteriormente en, otras sales, como el maleato. El amlodipino y sus sales tienen aplicabilidad industrial como principios activos antihipertensivos.
Patent ES-2255776-B1 (ES)
Title: Procedimiento de rotura facil en material termoplastico.
Inventor: PLA ESTRADA M TERESA
IPC: B29C45/00
Filed: 2003-01-15
Granted: 2007-06-16
Abstract: Procedimiento para la fabricación de una línea de rotura fácil en material termoplástico conseguido con llenados parciales del molde definidos por el perfil de un noyo retráctil que coincide con la zona debilitada. En esta zona debilitada al efectuar el segundo llenado se produce una soldadura en el enfriamiento del material, consiguiéndose así fabricar la línea de rotura evitando que las líneas de flujo atraviesen la misma.