baber/WOPTO huggingface dataset:
Patent AU-2015205530-B8 (AU)
Title: Multi-specific polypeptide useful for localized tumor immunomodulation
Inventor: OLWILL SHANE
IPC: C07K19/00
Filed: 2015-01-12
Granted: 2019-09-19
Abstract: The disclosure provides a multi-specific polypeptide with a first moiety specific for a tumor-associated antigen on tumor cell surface and a second moiety specific for an immune checkpoint protein, which multi-specific polypeptide can be useful for biasing a T-cell-mediated response to a tumor micro-environment. For example, the polypeptide may contain: a) a first binding domain, for example, a full-length antibody or an antigen-binding domain of an antibody, specifically recognizing a tumor- associated antigen on tumor cell surface, and b) a second binding domain, such as a lipocalin mutein, capable of stimulating T-cell proliferation e.g., by inhibiting a protein receptor that down-regulates the immune system. The first binding domain may be genetically linked (i.e., peptide bond at its N- or C- terminus) to the second binding domain. The multispecific polypeptide also may contain a third or yet additional specific binding moieties, any of which can specifically bind a distinct immune checkpoint protein. The polypeptide may contain an Fc region of an antibody or of an antigen-binding domain thereof and simultaneously engage (1 ) a T cell receptor complex of a T cell, (2) a tumor-associated antigen on tumor cell surface, while (3) preserving the Fc function of the Fc region to Fc receptor-positive cell. The polypeptide is useful for the induction of an anti-tumor immunity in humans and/or animals. The disclosure also provides thermal-stable lipocalin muteins specific for CTLA-4. The disclosure further relates to a process for the production of the polypeptide or muteins as well as nucleic acids encoding for the polypeptide or muteins, to vectors comprising the same and to host cells comprising the vector. In another aspect, the disclosure provides for a pharmaceutical composition comprising the polypeptide or muteins and medical uses of the polypeptide or muteins.
Patent BR-112012002069-B8 (BR)
Title: processo para a fabricação de um granulado contendo ezetimibe microcristalino
Inventor: GYÖRGY ÚJFALUSSY
IPC: A61K9/50
Filed: 2010-02-24
Abstract: processo de granulação e granulados assim preparados. a presente invenção refere-se a um processo para a fabricação de granulado contendo ezetimibe microcristalino, em que a) o ezetimibe é dissolvido; b) o ezetimibe dissolvido é precipitado com água, a qual se necessário contém excipientes farmacêuticos, de preferência derivados de lauril-sulfato; e c) os granulados são formados a partir da suspensão obtida mediante a pulverização da suspensão sobre os excipientes farmacêuticos. um outro aspecto da presente invenção é o granulado obtido pelo presente processo e a composição farmacêutica contendo tal granulado.
Patent BR-112017021002-B8 (BR)
Title: composição antimicrobiana, uso de uma composição, método para reduzir substancialmente ou controlar a formação de colônias microbianas sobre ou em uma superfície, sanitizantes para as mãos, produto para o cuidado de ferimentos, produto para cuidado ou higiene pessoal, produto para animais domésticos, e, lenço antimicrobiano
Inventor: CHRISTOPHER PLUMMER
IPC: A01N37/44
Filed: 2016-04-01
Abstract: esta invenção se refere a composições antimicrobianas que compreendem: um aminoácido, um derivado de um aminoácido, um sal de um aminoácido, um sal de um derivado de um aminoácido ou misturas dos mesmos; um componente antimicrobiano que compreende dois ou mais compostos de amônio quaternário antimicrobianos, ou pelo menos um composto de amônio quaternário antimicrobiano e clorexidina ou um sal da mesma; e um solvente polar, e a formulações que incluem as composições antimicrobianas. em particular, a invenção se refere a composições antimicrobianas que podem ser usadas na pele.
Patent EP-1994005-B9 (EP)
Inventor: BERGER MARKUS
IPC: A61P29/00
Filed: 2007-03-15
Granted: 2012-01-11
Abstract: L'invention concerne des dérivés de tétrahydronaphtalène plusieurs fois substitués de formule (Ia), des procédés de production desdits dérivés et leur utilisation comme anti-inflammatoires.
Patent AU-2014221310-B9 (AU)
Title: Earth leakage detector
Inventor: RES GIULIANO
IPC: G01R31/02
Filed: 2014-09-09
Granted: 2019-07-11
Abstract: An earth leakage detection circuit comprising; a current source, capable of drawing current from a sourcing power conductor, a current sink, sinking current to a sinking power conductor. The current source and current sink are each connected to earthed equipment which requires earth leakage detection protection. The current source and current sink enabling the earthed equipment having a low impedance to bias the earthed equipment to a voltage that is above an operational threshold for the current source and below an operational threshold for the current sink. Source Conductor Sink Leak Detected Current Source 12 12 - ~ arthed Components sourcee Leak Detected Sink Conductor 6 Figure 1 Block Diagram Source Conductor 6 -P Sink Conductoor16 Figure 2. Block Diagram
Patent AU-2014268843-B9 (AU)
Title: Ink to text representation conversion
Inventor: ISABEL MATTHEW
IPC: G06F17/24
Filed: 2014-05-19
Granted: 2019-05-16
Abstract: Technologies are generally provided for converting handwritten ink input to text annotations. A user may provide handwritten ink input to content displayed on a computing device to edit and mark up the content. The ink input may be provided employing touch or an electronic stylus on a user interface of the computing device to edit the content. The ink input may be processed to identify insertion of comments, deletion of text, and to identify insertion of markup symbols and shapes. The ink input may be converted to a text annotation based on a context of the ink input and a grammar and proofreading analysis. The text annotation may be displayed in an annotation view. The ink input may be converted periodically after predefined periods of time and upon detection of selection of a conversion button to activate conversion of the ink input.
Patent DE-102004009511-B9 (DE)
Title: Vorrichtung an Bord eines Fahrzeuges mit Benachrichtigungsfunktion für numerische Informationen
Inventor: TOYAMA KAZUMASA
IPC: H04B7/26
Filed: 2004-02-27
Granted: 2012-10-25
Abstract: In einer ETC-Vorrichtung (1) an Bord eines Fahrzeugs, wird eine Benachrichtigung betreffend eine Mautbetragsinformation mit einem Lauterzeugungsmuster eines Summers (17) gegeben. Die aus einer Mauterhebung resultierende Mautinformation, die mittels einer Antenne an der Straße durchgeführt wird, wird durch eine CPU (11) in ein Lauterzeugungsmuster umgewandelt. Wenn die Maut zum Beispiel 12300 Yen beträgt, ertönt der Summer (17) einmal mit einem langen Laut, zweimal mit einem mittleren Laut und dreimal mit einem kurzen Laut.
Patent DE-3107212-C1 (DE)
Title: Item of furniture having a plurality of cushions for use as a sofa bed or seat
Inventor: LIEBERKNECHT ARTHUR
IPC: A47C17/13
Filed: 1981-02-26
Granted: 1982-10-28
Abstract: Published without abstract.
Patent DE-3309786-C1 (DE)
Title: T-shaped closing piece for inserting into a T-shaped holding slot of a machine tool table
Inventor: WITTE ANDREAS
IPC: B25B11/00
Filed: 1983-03-18
Granted: 1984-07-19
Abstract: The device for holding workpieces uses a conventional machine table with dovetailed or T-shaped holding slots, with the proposal to insert closing pieces 1 into these holding slots, which closing pieces 1 in each case laterally close a holding slot 8 vacuum-tightly, in which arrangement a vacuum can be supplied via at least one closing piece. If a workpiece is accordingly put onto the holding slot section lying between the closing pieces, it is held in place by the vacuum. Conventional machine tables with holding slots which are only intended for mechanical fastening can thus be used as vacuum clamping plates. The closing piece is advantageously of two-piece design consisting of a top part 10 and a bottom part 11 in order to compensate for the relatively large tolerances, in particular in the height of the clamping slots. <IMAGE>
Patent DE-3334004-C1 (DE)
Title: Self-advancing powered support system and method of shifting a longwall face equipped with a self-advancing powered support system
Inventor: LUBOJATSKY WALTER DIPL-ING
IPC: E21D23/08
Filed: 1983-09-21
Granted: 1985-04-04
Abstract: The invention relates to a self-advancing powered support system for the face support in underground mine operation, the support assemblies of which are provided with self-advancing mechanisms which act perpendicularly to the working face and by means of which the support assemblies are moved forward in the direction of the working face. In order to facilitate the moving of a longwall face equipped with such a self-advancing support system, the invention proposes that the support assemblies have further self-advancing mechanisms which act parallel to the working face and by means of which the support assemblies are moved successively sideways parallel to the working face. This enables a rise heading to be produced at one head side of the face equipment over the width of the face and enables the self-advancing powered support system together with the entire face equipment to be moved sideways into this rise heading while maintaining the formation.
Patent DE-3408605-C1 (DE)
Title: Device for seed-spacing sowing, especially of beet
Inventor: BURS JOHANNES
IPC: A01C7/00
Filed: 1984-03-09
Granted: 1985-05-23
Abstract: The invention relates to a device for seed-spacing sowing, especially of beet, with a wheel which is arranged in front of a seed-supply container and rolls on the ground and which carries on its circumference radially displaceable sowing rams extracting the seed grains individually from a supply container and pressing them into the ground and is equipped with a ram drive, according to the invention the plunger (6) forming the sowing ram being surrounded, at its end penetrating into the ground, by a cap (26) provided with a small seed passage orifice (8) and made of permanently elastic material, a chamber (24) for receiving a seed grain (7) being formed between the cap (26) and the plunger end, and the plunger and cap being movable relative to one another in such a way that, when the plunger (6) is advanced, the seed passage orifice (8) is correspondingly widened elastically for the purpose of receiving or discharging a seed grain. <IMAGE>
Patent DE-3602730-C1 (DE)
Title: Distribution box for telecommunications cables
Inventor: EDUARD KOCH FRITZ
IPC: H02G3/18
Filed: 1986-01-30
Granted: 1987-05-21
Abstract: In order to create a distribution box for telecommunications cables, consisting of a base plate and a covering cap, the base plate having two different types of fastening parts, which can be attached in the corners, one of which types forms rear-engagement clips for closure parts of the cap and the other of which types forms internal-engagement clips for a closing mechanism which can be opened in an unauthorised manner only subject to permanent deformation or destruction, it is proposed that a swivel fastener (3) be attached to the covering plate of the cap (2) as the closing mechanism, whose locks (4), which are displaceable in opposite directions, are guided in slotted webs (5) which are attached to the cap, and that plastic mouldings (6) be arranged in the associated corners of the base plate (1) as internal-engagement clips for the locks (4), which plastic mouldings (6) extend virtually as far as the cover plate of the cap (2) when the cap (2) is fitted and have slots there, in the displacement path of the locks (4), as the lock internal-engagement clip. <IMAGE>
Patent DE-3643202-C1 (DE)
Inventor: WEIHRAUCH GEORG
IPC: B65H59/00
Filed: 1986-12-18
Granted: 1988-03-24
Abstract: A process for the manufacture of bristle products, from multifilament bristle strands wound in the form of endless material onto reels. The bristle strands, after unwinding, are supplied to a processing station, where they are fixed to a bristle carrier either in continuous or cut to size form. The removal from the spools takes place by a holding or tensile force acting in timed manner on the bristle strands at the processing station. In order to eliminate the non-uniform lengths of the individual monofilaments due to manufacture or processing and which lead to loop formation during processing, at least during the holding cycles acting on the processing station, a tensile force directed counter to the holding force acts on all the bristle strands. This tensile force is set in such a way that the bristle strands and, preferably, also all the monofilaments within a bristle strand are stretched between the spools and the processing station.
Patent DE-3721548-C1 (DE)
Title: Method for the harvesting of tree fruit and the like
Inventor: STENGER CHRISTOPH
IPC: A01D46/00
Filed: 1987-06-30
Granted: 1988-09-01
Abstract: The invention relates to a method for the harvesting of tree fruit, especially of seeds of forest trees, in which the fruit or seeds are detached from the trees by means of strong directed air streams, air jets or turbulent air streams and then fall down and are intercepted and collected on the ground by means of tarpaulins, nets or similar aids. The trees or forests to be harvested are flown over by means of an aircraft, for example a helicopter, which, as it flies, generates strong air streams in a direction directed vertically downwards, in such a way that the strong air streams detach the fruit or seeds from the trees. The method according to the invention can be carried out easily without high technical outlay and leads to a very high yield and productivity in the harvest.
Patent DE-3805041-C1 (DE)
IPC: B23D57/00
Filed: 1988-02-18
Granted: 1989-05-18
Abstract: In connection with a conversion set for a portable circular saw, which latter comprises a housing, an associated electric drive motor with output shaft and, if necessary, also a gear, and at least one handle, it is proposed to attach to the basic unit remaining after removal of the circular saw blade a chain-saw adapter attachment, to convert the portable circular saw in this manner into an electric chain saw and to secure the chain-saw adapter attachment in place by means of mechanical stops provided on a main bearing plate and coacting with the gear housing of the circular saw and, in the axial direction, by tightening a screw upon the output shaft of the circular saw projecting through the drive pinion for the saw chain.
Patent DE-3814007-C1 (DE)
Title: Radiator fixing
IPC: B60K11/04
Filed: 1988-04-26
Granted: 1989-04-27
Abstract: In a radiator fixing for motor vehicles an elastic damping sleeve, the bottom end of which is designed as spring key, is fitted on a part fixed to the vehicle. The radiator is seated on its bottom mounting and with a holder fitted on its upper end is supported by way of the said damping sleeve to prevent it tilting on the part fixed to the vehicle. At the same time the holder presses against the spring key and presses this against a convex stop face of the damping sleeve lying opposite it, thereby producing a positive compensation for vertical tolerances between the radiator on the one hand and that part fixed to the vehicle on the other. The complete fixing device is secured by a spring clip pushed over it and engaging in a locking bead on the holder.
Patent DE-3826456-C1 (DE)
Title: Bag arrangement
IPC: A61J1/05
Filed: 1988-08-04
Granted: 1990-03-08
Abstract: The invention relates to a bag arrangement (1) having one or more collapsible chambers (2) for accommodation of a liquid. Since conventional bags of this type do not permit the volume of the amount of liquid removed to be read off a scale printed on the bag wall, the bag (1) according to the invention has a non-collapsible tube (7) which can be connected in the manner of communicating tubes to a chamber (2) of the bag (1). As a result, determination of the amount of liquid removed is possible without any influence of the collapsing bag walls. <IMAGE>
Patent DE-3914258-C1 (DE)
Title: Vessel for treating small industrial parts in liq. bath - comprises horizontal rotatable drum with lid on horizontal trunnions held in bearings
IPC: C23C22/00
Filed: 1989-04-29
Granted: 1990-05-10
Abstract: For treating small industrial parts in a liquid bath, a vessel (2) is provided for the liquid, in which the drum (12) is supported via horizontal trunnions (4, 5) which are held in bearings.  The drum is closed by a lid (13) and is rotated about a horizontal axis perpendicular to its axis of symmetry.  An arm (23), which can be pivoted about a horizontal axis (24) and has a cylinder (26) with a connecting and locking arrangement (16, 17, 19) for attaching to the lid and removing it or replacing it. ADVANTAGE - Treatment of parts rending to stack together can be improved.
Patent DE-4129101-C1 (DE)
Title: Appts. for biologically cleaning air - includes bio-absorber unit with carriers of spherical, hollow parts having lateral ribs which dip into wash soln.
IPC: B01D53/84
Filed: 1991-09-02
Granted: 1993-04-08
Abstract: Appts. for biologically cleaning air, includes a biosorber unit with carriers consisting of spherical, hollow members with lateral ribs, which dip into the wash soln.. The carriers are covered with solid feeding bases. The bases are pref. put together in such a manner so that the removed air components are easily dismantled by the microorganisms. ADVANTAGE - Appts. is simple and robust, is economical and has a high output.
Patent DE-4223152-C1 (DE)
Inventor: JASCH INGOLF
IPC: A61N1/375
Filed: 1992-07-14
Granted: 1993-10-21
Abstract: The device for producing a micro-plug connector component (24, 30) consists of a cylindrical outer sleeve (1), a cylindrical central component (2) arranged coaxially in the outer sleeve (1) and several cylindrical spacers (3) arranged between the outer sleeve (1) and the central component (2). Between two adjacent spacers (3) there are cylindrical fitting components (4) which contact the adjacent spacers (3), the central component (2) and the outer sleeve (1). The fitting components (4) are long enough to project from the arrangement consisting of the outer sleeve (1), central component (2) and spacers (3). The micro-plug connector component (24, 30) produced with the device can be used for an electric power supply line (32). The contact components (5, 13) of the micro-plug connectors (24, 30) are connected to electric conductors (20) which, together with the micro-plug connector (24, 30), are surrounded by a continuous polyurethane.
Patent DE-4226810-C1 (DE)
Inventor: KRALL THEODOR DIPL ING
IPC: A61L31/00
Filed: 1992-08-13
Granted: 1994-01-27
Abstract: A process is disclosed for producing a plastic part upon which no germs and/or fungi can grow. The plastic material is preliminarily treated with a swelling agent and the thus swollen plastic material is then treated with a solution of a compound that contains a bactericidal and/or fungicidal metal
Patent DE-4234181-C1 (DE)
Inventor: HIERONIMUS FRANZ-JOSEF
IPC: E04D13/10
Filed: 1992-10-10
Granted: 1994-03-17
Abstract: A roof covering slab (10), in particular a concrete slab, has a holder (12) for roof fittings secured to its top side, approximately at its middle in the longitudinal direction, which extends in the longitudinal direction of the roof covering slab (10) and whose edges are laid on the roof covering slab. At least one reinforcing projection (14) arranged on the lower side of the roof covering slab (10) extends from the end (24) of the slab next to the ridge of the roof down to the beginning of the covering section (26) at the end (28) of the slab next to the eaves. A bearing surface (18) corresponding to the profile of the edge (16) of the holder (12) is shaped on the top side of the roof covering slab (10), and within this bearing surface (18) is formed a raised area (20) which form-fittingly engages the holder (12). The holder (12) is secured to the roof covering slab (10) by means of at least one non-detacheable coupling element (22). A horn (38) may be provided on the top side of the holder (12), at its end (28) next to the eaves, and fastening elements (40, 42), as well as concave cylindrical bearing surfaces (48 or 50) adapted to the lower profile of a fitting, may be provided at the horn (38) and at the end of the holder next to the roof ridge.
Patent DE-4239552-C1 (DE)
Inventor: NIESE KARL
IPC: A47J27/08
Filed: 1992-11-25
Granted: 1994-04-28
Abstract: A pressure cooker is proposed, whose lid (2) has a hood (6) which, for residual-pressure reduction and subsequent opening avoiding a rotational movement, is to be displaced with respect to the pot (1) solely in the vertical direction. In this arrangement, tongues (36), projecting downwards between hood rim and pot rim (5), ensure, in cooperation with the guide slots (37) in the clamps (10) holding pot (1) and lid (2) together, radial opening and closing displacements of the clamps (10). A centring ring (8), arranged in the hood (6) and reaching into the pot (1), facilitates the mounting of the lid onto the pot. The centring ring (8) carries the sealing ring (7) and the tongues (36) and is stressed, by means of springs (30) resting on the hood (6), in the direction leading away from the hood. Hood (6) and centring ring (8) are guided on one another and can be locked to one another in the open position by means of elements (27, 29) engaging with one another. On closing the pressure cooker, the locking mechanism is released, and the springs effect both the closing displacement of the clamps and the positioning of the sealing ring (7) with respect to its sealing-off faces on hood and pot. <IMAGE>
Patent DE-4329587-C1 (DE)
Title: Apparatus for filtering liquid
Inventor: BENDER JUERGEN
IPC: B01D29/11
Filed: 1993-09-02
Granted: 1994-09-15
Abstract: An apparatus for filtering liquid having a housing (3) provided with a feed (1) and an outlet (2) and a filter (4) acting between the feed (1) and outlet (2), to decrease the operating costs, in particular to economise on filter cleaning, is designed and developed in such a manner that a tube (5) forming a flow path and opening towards the outside of the housing (3) extends from the feed (1) through the housing (3) and that the filter (4) is an integral constituent of the tube wall. <IMAGE>
Patent DE-4334754-C1 (DE)
Title: Sealing space between plunger and cylindrical container esp. cartridge for adhesive or sealant
Inventor: LEPKA WOLFGANG DR
IPC: B65D83/00
Filed: 1993-10-12
Granted: 1995-05-24
Abstract: In sealing the space between the cylindrical outside surface of the push plunger and the inside surface of the cylindrical container, esp. of a cartridge, the sealant used comprises a mixt. (I) of butene polymer (II) and wax. A sealant compsn. is also claimed.
Patent DE-4421150-C1 (DE)
Title: Auxiliary release device fixing system for LV power switch
Inventor: LIEBETRUTH MARC DIPL ING
IPC: H02B1/04
Filed: 1994-06-10
Granted: 1996-01-04
Abstract: The fixing system uses a carrier (2) provided by the power switch, with a support surface (13) on which the base plate (3) of the auxiliary release device (1) rests. The base plate has a ratchet nose, cooperating with a counter-bearing (5) of the carrier at one side edge of the base plate, the opposite side edge cooperating with a locking nose (16), provided by a spring tongue (14) of the carrier. The spring tongue is acted on by a manually operated locking element, to prevent the release of the base plate, pref. provided by a wedge element (20), fitting between the locking nose and a support element (17) of the carrier, to clamp the locking nose against the base plate.