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drug_combination | What is the drug combination mentioned in the following sentence? In this challenging field , aflibercept offers a good option for oxaliplatin-refractory mCRC patients when combined with irinotecan and 5-fluorouracil irrespective of prior anti-angiogenic treatment . | aflibercept irinotecan 5-fluorouracil are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? The combination of 1-hour paclitaxel , carboplatin , and extended oral schedule etoposide is feasible and well tolerated at the doses administered in this phase II trial . | paclitaxel carboplatin etoposide are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? In this regard , we have synthesized Pem-PEG-Gem , wherein pemetrexed ( Pem ) and gemcitabine ( Gem ) are conjugated to a heterobifunctional polyethylene glycol ( PEG ) polymer for the effective treatment of Non-Small Cell Lung Cancer ( NSCLC ) . | pemetrexed gemcitabine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? After the initiation of antimalarial treatment with artesunate and mefloquine , his clinical condition gradually improved . | artesunate mefloquine are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? For those few patients who do not respond to first-line therapy , the combination of vinblastine , ifosfamide , and cisplatin is the most popular regimen for the subset of platinum-sensitive tumors . | vinblastine ifosfamide cisplatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Patients received once-daily vandetanib ( planned dosing levels of 100 , 200 , and 300 mg ) with concomitant daily radiotherapy ( 1.8 Gy/d , 45 Gy total ) and chemotherapy , consisting of infusional 5-FU ( 225 mg/m/d over 96 h , weekly ) , paclitaxel ( 50 mg/m , days 1 , 8 , 15 , 22 , 29 ) and carboplatin ( AUC of 5 , days 1 , 29 ) . | vandetanib 5-FU paclitaxel carboplatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The calcium channel blocker verapamil has been previously shown to augment the chemosensitivity of pancreatic adenocarcinoma cell lines to doxorubicin by mechanisms other than changes in the intracellular accumulation , retention , or metabolism of doxorubicin . | verapamil doxorubicin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The results of a randomized phase II trial have demonstrated that the addition of cetuximab to irinotecan in patients with irinotecan-resistant tumors represents another active treatment option for these patients . | cetuximab irinotecan are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Normal heart rate and rhythm were then preserved temporarily with digoxin and flecainide . | digoxin flecainide are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? A phase I/II and pharmacokinetic study of irinotecan in combination with capecitabine as first-line therapy for advanced colorectal cancer . | irinotecan capecitabine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The purpose of this study was to determine whether combination therapy with vancomycin and TZP is associated with an incidence of AKI in pediatric patients higher than that in those on combination therapy with vancomycin and cefepime . | vancomycin TZP are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? In patients who experience disease progression after etoposide , doxorubicin , cisplatin with mitotane ( EDP-M ) , gemcitabine and metronomic capecitabine , or the less used streptozotocin , represent a second-line chemotherapy option . | gemcitabine capecitabine are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? We conclude that ropivacaine alone injected into the pterygomandibular region does not affect the cardiovascular system and that the addition of epinephrine has no beneficial effect . | ropivacaine epinephrine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The next broad-spectrum drug was ethionamide , followed by ansamycin , rifampin , capreomycin , kanamycin , streptomycin and ethambutol . | ethionamide rifampin capreomycin kanamycin streptomycin ethambutol ansamycin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Phase I/II study of gefitinib and capecitabine in patients with colorectal cancer . | gefitinib capecitabine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Both the BTK inhibitor ibrutinib and the BCL2 inhibitor venetoclax are active as monotherapy in the treatment of mantle-cell lymphoma . | ibrutinib venetoclax are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? A group of 14 patients with small-cell lung cancer received a 1-h intravenous infusion of 2.0 or 3.0 g/m2 ifosfamide over 1 or 2 days in combination with 175 mg/m2 paclitaxel and carboplatin at AUC 6 . | ifosfamide paclitaxel carboplatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Ticlopidine and clopidogrel achieve antiplatelet effects by inhibiting the binding of adenosine 5'-disphosphate to its platelet receptor . | Ticlopidine clopidogrel are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Irinotecan plus gemcitabine induces both radiographic and CA 19 - 9 tumor marker responses in patients with previously untreated advanced pancreatic cancer . | Irinotecan gemcitabine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The patient was treated with a combination of cyclophosphamide , doxorubicin , vincristine , and prednisone as initial management immediately after diagnosis . | cyclophosphamide doxorubicin vincristine prednisone are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? To our knowledge , we present the first reported case of SS associated with linezolid and methadone with a brief review of the literature . | linezolid methadone are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Recent clinical trials have reported improved survival for two novel agents ; ipilimumab , a humanized , IgG1 monoclonal antibody that blocks cytotoxic T-lymphocyte-associated antigen 4 ( CTLA-4 ) and vemurafenib , a BRAF ( v-raf murine sarcoma viral oncogene homolog B1 ) inhibitor targeting an activating mutation in the serine-threonine-protein kinase BRAF gene . | ipilimumab vemurafenib are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Three interventions exhibited significantly improved OS results over chemotherapy ( all HR < 1 ): Ipilimumab , Nivolumab and Ipilimumab + Chemotherapy . | Ipilimumab Nivolumab Ipilimumab Chemotherapy are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? The breast trial participants studied were those elderly enrolled between 1995 and 1997 and treated with doxorubicin and cyclophosphamide or this combination with paclitaxel . | doxorubicin cyclophosphamide are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The intensive polychemotherapy regimen eBEACOPP ( bleomycin , etoposide , doxorubicin , cyclophosphamide , vincristine , procarbazine , and prednisone in escalated doses ) is very active in patients with advanced-stage Hodgkin 's lymphoma , albeit at the expense of severe toxicities . | bleomycin etoposide doxorubicin cyclophosphamide vincristine procarbazine prednisone are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Systemic treatments , and here in particular a combined therapeutic regimen of chemotherapy and electron beam , bexarotene , or denileukin diftitox , showed more adverse effects than topical or skin-directed treatments . | bexarotene denileukin diftitox are the drug combinations. No need for context. It is a NEG combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Risk factors associated with cardiotoxicity within 2 years of doxorubicin administration included age [ adjusted hazard ratio ( aHR ) = 1.02 , 95 % confidence interval ( CI ) 1.00 - 1.04 ; p = 0.05 ] , metastasis ( aHR = 2.66 ; 95 % CI 1.36 - 5.20 ; p < 0.01 ) , and concomitant trastuzumab ( aHR = 4.08 ; 95 % CI 2.31 - 7.21 ; p | doxorubicin trastuzumab are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Twenty-four patients have been treated to date , and the maximum tolerated dose has been reached at paclitaxel 185 mg/m2 and carboplatin 350 mg/m2 . | paclitaxel carboplatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? [ Aztreonam or gentamicin combined with piperacillin as empiric antibiotic therapy during neutropenia of patients with hematologic diseases ] . | Aztreonam piperacillin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The present study was undertaken to further elucidate the effect of salbutamol on the pharmacokinetics of digoxin in man . | salbutamol digoxin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Mecamylamine reversed the effects of nicotine on SHR performance . | Mecamylamine nicotine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The combination of sub-effective doses of leflunomide and cyclosporin A resulted in significant inhibition of chronic arthritis . | leflunomide cyclosporin are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? In the metastatic setting , FOLFIRINOX ( folinic acid , 5-fluorouracil , irinotecan , and oxaliplatin ) , and nab-paclitaxel plus gemcitabine have yielded only modest improvements in survival . | folinic 5-fluorouracil irinotecan oxaliplatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Patients in arm 1 ( n = 88 ) received 4 cycles of paclitaxel and carboplatin followed by 2 to 4 cycles of gemcitabine-based combination chemotherapy . | paclitaxel carboplatin gemcitabine-based are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? In patients receiving digoxin and propafenone simultaneously , the SDCs should be monitored and the digoxin dose reduced if there is evidence of toxicity . | digoxin propafenone are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? To review the clinical effectiveness and cost-effectiveness evidence base for lapatinib ( LAP ) in combination with an aromatase inhibitor ( AI ) and trastuzumab ( TRA ) in combination with an AI for the first-line treatment of patients who have hormone receptor-positive (HR+)/human epidermal growth factor 2-positive ( HER2 + ) mBC . | lapatinib AI are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Since combination therapy with nateglinide and vildagliptin restored the decrease in pancreatic beta cell mass , our present findings suggest that combination therapy could be a promising therapeutic strategy for postprandial dysmetabolism associated with obese and insulin resistance . | nateglinide vildagliptin are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Patients were randomised to receive either four or eight courses of cytotoxic chemotherapy with cyclophosphamide , vincristine and etoposide and also randomised to receive , on disease progression , either second line chemotherapy ( methotrexate and doxorubicin ) or symptomatic treatment only . | cyclophosphamide vincristine etoposide are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Tazobactam has inhibitory activity , and therefore protects piperacillin against Richmond and Sykes types II , III , IV and V beta-lactamases , staphylococcal penicillinase and extended-spectrum beta-lactamases . | Tazobactam piperacillin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The diagnosis was stage IIIA HHV-8-LBL , and he was treated with 6 cycles of R-EPOCH ( rituximab , etoposide , vincristine , doxorubicin , cyclophosphamide , and prednisone ) infusion chemotherapy . | rituximab etoposide vincristine doxorubicin cyclophosphamide prednisone are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Our objective was to define the maximum tolerated dose of an escalating dose of ifosfamide in combination with a fixed dose of doxorubicin supported by granulocyte colony-stimulating factor ( Neupogen ) . | ifosfamide doxorubicin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? A combined analysis of two pivotal randomized trials of a single dose of pegfilgrastim per chemotherapy cycle and daily Filgrastim in patients with stage II-IV breast cancer . | pegfilgrastim Filgrastim are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? At initial treatment with dabrafenib plus trametinib , three patients achieved a partial response and one patient achieved a complete response . | dabrafenib trametinib are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? We performed this meta-analysis to evaluate the clinical efficacy and safety of gemcitabine plus cisplatin ( GP ) and paclitaxel plus cisplatin ( TP ) combined with thermotherapy in the treatment of NSCLC , as well as to provide reference for clinical practice and future research . | gemcitabine cisplatin thermotherapy are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The pharmacodynamic effects of ticagrelor were preserved when ticagrelor was given during infusion of cangrelor . | ticagrelor cangrelor are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? A 49-year-old woman diagnosed with International Federation of Obstetricians and Gynecologists stage 2018 IIIC2 locally advanced undifferentiated cervical cancer received first-line chemoradiotherapy followed by carboplatin , paclitaxel , and bevacizumab with partial response . | carboplatin paclitaxel bevacizumab are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Sipuleucel-T , cabazitaxel , abiraterone , enzalutamide and radium-223 have been approved in the pre- or post-docetaxel setting in metastatic CRPC during the last few years . | Sipuleucel-T cabazitaxel abiraterone enzalutamide radium-223 are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Therefore , we conducted this phase II study to evaluate the activity and toxicity of the combination paclitaxel and gemcitabine in advanced NSCLC . | paclitaxel gemcitabine are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Ciprofloxacin , 500 mg orally twice a day plus antifungal prophylaxis , fluconazole 50 mg once daily plus amphotericin B tablets or suspension and tablets , each 200 mg four times a day , was given . | Ciprofloxacin fluconazole amphotericin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? In some recently updated clinical guidelines , the fully humanized monoclonal antibody panitumumab , combined with irinotecan , has been recommended as an optional third-line chemotherapy for KRAS wild-type metastatic colorectal cancer ( mCRC ) . | panitumumab irinotecan are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? A monocentric phase I study of vemurafenib plus cobimetinib plus PEG-interferon ( VEMUPLINT ) in advanced melanoma patients harboring the V600BRAF mutation . | vemurafenib cobimetinib VEMUPLINT are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Phase 1 dose-escalation trial of tremelimumab plus sunitinib in patients with metastatic renal cell carcinoma . | tremelimumab sunitinib are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? A working group convened by the Centers for Disease Control recommended three antibiotics for the treatment of recurrent and persistent acute otitis media : ( 1 ) amoxicillin/clavulanate in combination with amoxicillin ( high dose amoxicillin regimen , 80 to 90 mg/kg/day ) ; ( 2 ) cefuroxime axetil ( standard dose , 30 mg/kg/day ) ; and ( 3 ) ceftriaxone ( possibly requiring up to three injections to optimize clinical success ) . | amoxicillin/clavulanate amoxicillin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Patients who had failed only one prior chemotherapy regimen and had Eastern Cooperative Oncology Group ( ECOG ) Performance Status ( PS ) ≤2 were randomised to either : pemetrexed 500 mg/m(2 ) on day 1 plus erlotinib 150 mg daily on days 2 - 14 ; erlotinib 150 mg daily ; or pemetrexed 500 mg/m(2 ) on day 1 of a 21-day cycle until discontinuation criteria were met . | pemetrexed erlotinib are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? This study was conducted to test the feasibility of reducing the interval between cycles of doxorubicin , cyclophosphamide , etoposide ( ACE ) chemotherapy to 2 weeks , thereby increasing dose intensity , by adding granulocyte colony-stimulating factor ( G-CSF ) to reduce the duration of neutropenia following a cycle . | doxorubicin cyclophosphamide etoposide G-CSF are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The rate of down-stage to pT1 or less was 59 % for methotrexate , vinblastine , doxorubicin and cisplatin , and 53 % for gemcitabine and carboplatin ( P = 0.624 ) . | gemcitabine carboplatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? The combined irrigation of bupivacaine and ketorolac showed a clinically significant reduction of pain in the first postoperative hour and on postoperative day 5 . | bupivacaine ketorolac are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? In group I , clinical response was observed in 10 of 19 febrile episodes ( 52.6 % ) treated with carbenicillin plus gentamicin and in 10 of 14 ( 71.4 % ) treated with latamoxef ( p greater than 0.05 ) . | carbenicillin gentamicin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Following lapatinib and trastuzumab , the HER2-E and ERBB2 (HER2-E/ERBB2)-high group showed a higher pCR rate compared to the rest ( 44.5 % , 95 % confidence interval [ CI ] = 35.4 % to 53.9 % vs 11.6 % , 95 % CI = 6.9 % to 18.0 % ; adjusted odds ratio [ OR ] = 6.05 , 95 % CI = 3.10 to 11.80 , P < .001 ) . | lapatinib trastuzumab are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? A Synergistic Anti-Cancer Effect of Troglitazone and Lovastatin in a Human Anaplastic Thyroid Cancer Cell Line and in a Mouse Xenograft Model . | Troglitazone Lovastatin are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Fingolimod sensitizes EGFR wild‑type non‑small cell lung cancer cells to lapatinib or sorafenib and induces cell cycle arrest . | Fingolimod lapatinib are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Bacteriological , histopathologic , and clinical outcomes after treatment using moxifloxacin , moxifloxacin and dexamethasone combination , and vancomycin were comparable . | moxifloxacin dexamethasone are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Combining erythromycin , clarithromycin , or azithromycin with rifampin resulted in a significant ( P≤0.005 ) decrease in MPC and MPC/MIC ratio . | erythromycin rifampin are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? This was confirmed and show that the dCK levels are retained upon co-treatment , indicating a clinical use for bortezomib treatment in combination with cytarabine to avoid development of resistance . | bortezomib cytarabine are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Effects of fenofibrate and its combination with lovastatin on the expression of genes involved in skeletal muscle atrophy , including FoxO1 and its targets . | fenofibrate lovastatin are the drug combinations. Need more context. |
drug_combination | What is the drug combination mentioned in the following sentence? Idasanutlin was tolerable alone and in combination with cytarabine . | Idasanutlin cytarabine are the drug combinations. No need for context. It is a POS combination. |
drug_combination | What is the drug combination mentioned in the following sentence? After seven days of chemotherapy with 5-fluorouracil , oxaliplatin and bevacizumab , exploratory surgery revealed a perforation at the ileum . | 5-fluorouracil oxaliplatin bevacizumab are the drug combinations. No need for context. It is a NEG combination. |
drug_combination | What is the drug combination mentioned in the following sentence? Nausea graded none or mild 24 h after the start of cisplatin infusion was reported in 71 and 69 % of patients in the 8- and 32-mg ondansetron groups , respectively , and in 73 % of patients in the granisetron group . | cisplatin ondansetron are the drug combinations. No need for context. It is a POS combination. |