Datasets:

amanbawa96
/

drug_combo

+qtype,Question,Answer
+drug_combination,"What is the drug combination mentioned in the following sentence? Between 1987 and 2003 , patients 18 years old were given adjuvant chemotherapy consisting of one of two ' paediatric ' regimens ( depending on the time of presentation ) and craniospinal local-boost radiotherapy : regimen A ( n = 12 ) , vincristine ( VCR ) , intrathecal and/or intravenous methotrexate and conventional radiotherapy ; or regimen B ( n = 11 ) sequencing intensive doses of multiple agents followed by hyperfractionated accelerated radiotherapy ( HART ) .",vincristine methotrexate are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? The US Food and Drug Administration ( FDA ) recommends that "" concomitant use of drugs that inhibit CYP2C19 ( e.g. , omeprazole ) should be discouraged . "" As the presence of PPIs and clopidogrel in plasma is short lived , separation by 12 - 20 h should in theory prevent competitive inhibition of CYP metabolism and minimize any potential , though unproven , clinical interaction .",omeprazole clopidogrel are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Long-term overall- and progression-free survival after pentostatin , cyclophosphamide and rituximab therapy for indolent non-Hodgkin lymphoma .",cyclophosphamide rituximab pentostatin are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Once-weekly isoniazid and rifapentine for 3 months is a treatment option in persons with human immunodeficiency virus and latent tuberculosis infection .,isoniazid rifapentine are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? We hypothesized that Aurora A kinase ( AK ) contributes to castrate resistance in prostate cancer ( PCa ) and that inhibiting AK with alisertib can resensitize PCa cells to androgen receptor ( AR ) inhibitor abiraterone .,alisertib abiraterone are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Tanespimycin plus trastuzumab is well tolerated and has antitumor activity in patients with HER-2 + breast cancer whose tumors have progressed during treatment with trastuzumab .,Tanespimycin trastuzumab are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? It contains data on prophylaxis with mefloquine ( n = 48,264 ) , with chloroquine ( 6,752 ) , with chloroquine plus proguanil ( 19,727 ) , and with no prophylaxis ( 3,871 ) .",chloroquine proguanil are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? We hypothesized that the brain damage mitigating effect of mild hypothermia after cardiac arrest can be enhanced with thiopental loading , and even more so with the further addition of phenytoin and methylprednisolone .",phenytoin methylprednisolone are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? In the xenograft model , more augmented effects were achieved when bortezomib was combined with gemcitabine than gemcitabine alone .",bortezomib gemcitabine are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? The effectiveness of combination therapy with afatinib and bevacizumab may provide a new therapeutic option for these patients .,afatinib bevacizumab are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Clinical activity of enzalutamide versus docetaxel in men with castration-resistant prostate cancer progressing after abiraterone .,enzalutamide abiraterone are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? The use of cyclophosphamide in patients with NSVN is controversial , but recent retrospective data suggest that those treated with prednisone and cyclophosphamide from the outset fare better than those initially treated only with prednisone .",prednisone cyclophosphamide are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? This was a multi-center randomized , two-armed , double-blinded phase II study comparing cediranib plus gefitinib versus cediranib plus placebo in subjects with first relapse/first progression of glioblastoma following surgery and chemoradiotherapy .",cediranib gefitinib are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Combinations of penicillin and streptomycin and penicillin and amikacin were synergistic only against those strains that were not highly resistant to streptomycin and kanamycin , respectively .",streptomycin penicillin are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? Treatment with a combination chemotherapeutic regimen consisting of cyclophosphamide , vincristine , and dacarbazine for malignant paraganglioma with hepatic metastasis is reported .",cyclophosphamide vincristine dacarbazine are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? The most effective treatment regimens for advanced nonseminomatous testicular tumors employ vinblastine , CDDP and bleomycin and adjunctive surgery .",vinblastine bleomycin are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? 27 patients suffering from disseminated carcinoma of the breast with at least two visceral metastases , and two had become resistant to conventional chemotherpy and hormones , received a combination of , in the present trial , vincristine followed by cyclophosphamide with 5-fluoro-uracil .",vincristine cyclophosphamide 5-fluoro-uracil are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? We previously demonstrated that the combination of oral estramustine ( 15 mg/kg/day ) and oral etoposide ( 50 mg/m2/day ) is effective first-line therapy for the treatment of hormone refractory prostate cancer .,estramustine etoposide are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? Therapy consisted of bendamustine ( 70 mg/m(2 ) ) for 2 consecutive days every 28 days , and ofatumumab 300 mg on day 1 and 1000 mg on day 8 during the first cycle , and 1000 mg on day 1 subsequently .",bendamustine ofatumumab are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? All consecutive patients with advanced BTC received the GEMOX regimen in a setting outside a study : gemcitabine 1,000 mg/m(2 ) on day 1 , and oxaliplatin 100 mg/m(2 ) on day 2 , treatment repeated every 2 weeks until progression or unacceptable toxicity .",gemcitabine oxaliplatin are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Recent randomized controlled trials ( RCT ) have failed to demonstrate the efficacy of widely used therapies , such as rituximab plus intravenous immunoglobulin or proteasome inhibition ( bortezomib ) , reinforcing a great need for new therapeutic concepts .",rituximab intravenous immunoglobulin are the drug combinations. No need for context. It is a NEG combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? The aim of this study was to find an experimental model of a donor-recipient rat strain combination that , under triple drug immunosuppressive treatment ( methylprednisolone , cyclosporine , and azathioprine ) , would develop chronic rejection within a few weeks .",methylprednisolone cyclosporine azathioprine are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? In FOLL05 trial , R-CHOP was compared with R-CVP ( cyclophosphamide , vincristine , prednisone ) and R-FM ( fludarabine , mitoxantrone ) .",cyclophosphamide vincristine prednisone are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? All patients underwent 3 cycles of neoadjuvant gemcitabine , paclitaxel , and capecitabine .",gemcitabine paclitaxel capecitabine are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? The aim of the present investigation was to study and characterize the effect of voriconazole on the fungicidal activity of amphotericin B.,voriconazole amphotericin B. are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Dual Therapy with Aspirin and Cilostazol May Improve Platelet Aggregation in Noncardioembolic Stroke Patients : A Pilot Study .,Aspirin Cilostazol are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Gemcitabine and vinorelbine have shown activity in the first-line setting .,Gemcitabine vinorelbine are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? The combination of tenofovir disoproxil fumarate ( TDF ) plus emtricitabine ( FTC ) is used extensively to treat HIV infection and also has potent activity against hepatitis B virus ( HBV ) infection .,tenofovir disoproxil fumarate emtricitabine are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Pegylated liposomal doxorubicin plus cyclophosphamide followed by paclitaxel as primary chemotherapy in elderly or cardiotoxicity-prone patients with high-risk breast cancer : results of the phase II CAPRICE study .,doxorubicin cyclophosphamide paclitaxel are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? We randomly assigned 410 women with advanced ovarian cancer and residual masses larger than 1 cm after initial surgery to receive cisplatin ( 75 mg per square meter of body-surface area ) with either cyclophosphamide ( 750 mg per square meter ) or paclitaxel ( 135 mg per square meter over 24 hours ) .,cisplatin paclitaxel are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Changes in cholesterol absorption and cholesterol synthesis caused by ezetimibe and/or simvastatin in men .,ezetimibe simvastatin are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? We now present the long-term follow-up findings of a randomized phase III study on the addition of six cycles of procarbazine , lomustine , and vincristine ( PCV ) chemotherapy to radiotherapy ( RT ) .",procarbazine lomustine vincristine radiotherapy are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? A phase II clinical trial was conducted to evaluate the efficacy and toxicity of vinorelbine plus gemcitabine in very old patients with inoperable ( stage IIIb or IV ) NSCLC .,vinorelbine gemcitabine are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Tobramycin was probably less effective than gentamicin in combination with the penicillinase-resistant penicillins against enterococci .,gentamicin penicillins are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? The clinical studies provide evidence that combined fluticasone/formoterol is more efficacious than fluticasone or formoterol given alone , and provides similar improvements in lung function to fluticasone ( Flixotide ( ® ) ) and formoterol ( Foradil ( ® ) ) administered concurrently .",fluticasone formoterol are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Paclitaxel showed synergistic anti-proliferative impacts with fulvestrant .,Paclitaxel fulvestrant are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? The experimental protocol was as follows : ( 1 ) at time zero , intravenous infusion of ritodrine was begun ; ( 2 ) at 120 min , 2 % lidocaine was given epidurally to achieve a sensory level of at least T6 ; and ( 3 ) at 135 min , an intravenous bolus of either ephedrine , phenylephrine , or normal saline-control was given , followed by a continuous intravenous infusion of the same agent for 30 min .",ritodrine lidocaine ephedrine are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? compared to busulfan and cyclophosphamide as conditioning regimen for allogeneic stem cell transplant from matched siblings and unrelated donors for acute myeloid leukemia .,busulfan cyclophosphamide are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Posttransplant immunosuppression to prevent graft-versus-host disease ( GVHD ) consisted of cyclosporine and prednisone ( CSA/PSE ) .,cyclosporine prednisone are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Either 5-fluorouracil ( 5-FU ) and leucovorin for 6 months or 5-FU and levamisole for 12 months are currently considered standard adjuvant treatment for stage III colorectal cancer .,leucovorin 5-FU are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Efficacy of sorafenib combined with the pan-CDK inhibitor flavopiridol was tested both in vitro and in xenograft experiments .,sorafenib flavopiridol are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Codelivery of sorafenib and curcumin by directed self-assembled nanoparticles enhances therapeutic effect on hepatocellular carcinoma .,sorafenib curcumin are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? Single treatment of closantel plus albendazole mixture reduced egg counts in camels by 100 % , 100 % , 98 % and 77 % for Haemonchus longistipes , Ascaris spp . , Monezia expansa and Fasciola hepatica , respectively .",closantel albendazole are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Second-line chemotherapy was also ineffective ; therefore , the bevacizumab and irinotecan were given after a third gross-total resection of the tumor .",bevacizumab irinotecan are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Treatment with rapamycin and paclitaxel resulted in decreased phosphorylation of S6 and 4E-BP1 , two critical downstream targets of the mTOR pathway .",rapamycin paclitaxel are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Conversely , the IMbrave150 trial recently showed that , among patients with previously untreated unresectable HCC , treatment with atezolizumab plus bevacizumab resulted in significantly longer overall survival and progression-free survival compared to sorafenib monotherapy .",atezolizumab bevacizumab are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Evaluation of tamoxifen plus letrozole with assessment of pharmacokinetic interaction in postmenopausal women with metastatic breast cancer .,tamoxifen letrozole are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? The EVERLAR study reports prospective data of somatostatin analogue in combination with everolimus in nonfunctioning gastrointestinal neuroendocrine tumors suggesting meaningful activity and favorable toxicity profile that supports drug combination in this setting .,somatostatin everolimus are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Synergism between anti-HER2 monoclonal antibody ( trastuzumab ) and paclitaxel has been shown in vitro and in vivo .,trastuzumab paclitaxel are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? Cardiac events occurred after posaconazole administration , incriminating posaconazole use , alone or in combination with voriconazole , as the culpable agent .",posaconazole voriconazole are the drug combinations. No need for context. It is a NEG combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? Prognostic value of expression of Kit67 , p53 , TopoIIa and GSTP1 for curatively resected advanced gastric cancer patients receiving adjuvant paclitaxel plus capecitabine chemotherapy .",paclitaxel capecitabine are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? The standard adjuvant treatment of colon cancer is fluorouracil plus leucovorin ( FL ) .,fluorouracil leucovorin are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? Thirty-four patients ( 4 patients with stage IIIb , 30 patients in stage IV ) , with median age 66 and performance status 0 - 1 , were administered paclitaxel , 175 mg/m(2 ) in a 3-h infusion rate on day 1 and vinorelbine , 25 mg/m(2 ) in a 10-min infusion rate on days 1 , and 8 with G-CSF and EPO support .",paclitaxel vinorelbine are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia .,decitabine valproic are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Patients received docetaxel 35 mg/m(2 ) and irinotecan 60 mg/m(2 ) , intravenously , on Days 1 and 8 , every 21 days , until disease progression .",docetaxel irinotecan are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Most patients with advanced ovarian cancer achieve a clinical complete remission following cytoreductive surgery and chemotherapy with paclitaxel plus carboplatin .,paclitaxel carboplatin are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? First-line chemotherapy was either R-CHOP ( rituximab , cyclophosphamide , doxorubicin , vincristine and prednisolone ) or CHOP-like-based regimen .",rituximab cyclophosphamide doxorubicin vincristine prednisolone are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? The combination of rituximab with vincristine and 5-day cyclophosphamide is able to produce CR in patients with advanced follicular lymphoma , even in patients resistant to third-generation regimens .",rituximab vincristine cyclophosphamide are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? These results confirm that sequential decitabine and carboplatin requires further investigation as a combination treatment for melanoma .,decitabine carboplatin are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? [ Rhabdomyosarcoma of the urinary bladder : complete remission induced by vinblastine , cis-platinum , and bleomycin ] .",vinblastine bleomycin cis-platinum are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? Recent comparative studies suggest that atenolol ( 200 mg daily ) , metoprolol ( 200 mg daily ) ; acebutolol ( 400 mg daily ) , oxprenolol ( 160 mg daily ) , nadolol ( 80 mg daily ) and timolol ( 20 mg daily ) produce a beneficial clinical response equal to that seen with propranolol ( 160 mg daily ) .",atenolol metoprolol acebutolol oxprenolol nadolol timolol are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? All the animals in the placebo group had tumors in each lobe compared with only 43 % each in the dorsolateral ( DLP ) and anterior prostate ( AP ) of the animals treated with raloxifene ( 10 mg/kg/day ) plus nimesulide .,raloxifene nimesulide are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Abiraterone acetate and prednisone in the pre- and post-docetaxel setting for metastatic castration-resistant prostate cancer : a mono-institutional experience focused on cardiovascular events and their impact on clinical outcomes .,Abiraterone prednisone are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Nivolumab plus ipilimumab combined therapy is among the most effective therapies for advanced melanoma .,Nivolumab ipilimumab are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? Cells that were sequentially exposed to rapamycin and topotecan had significantly higher levels of cleaved caspase-8 , -3 , and PARP compared to those treated with topotecan alone .",rapamycin topotecan are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Synergistic cytotoxic effects of recombinant human tumor necrosis factor and Etoposide ( VP16 ) or Doxorubicin on A2774 human epithelial ovarian cancer cell line .,human tumor necrosis factor Etoposide are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? The resistance of topotecan in MDR HL-60 cells was potently reversed by the addition of amlodipine .,topotecan amlodipine are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? [ Clinical evaluation of effects from neoadjuvant chemotherapy with epirubicin plus paclitaxel in cases of locally advanced breast cancer -- comparative study of treatment with 2 and 4 cycles ] .,epirubicin paclitaxel are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? When systemically active chemotherapy doses were reached , further dose escalation was discontinued , and a phase II dose-range was established ( pemetrexed 500 mg/m(2 ) and carboplatin AUC = 5 - 6 ) .",pemetrexed carboplatin are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Increased dose density is feasible : a pilot study of adjuvant epirubicin and cyclophosphamide followed by paclitaxel , at 10- or 11-day intervals with filgrastim support in women with breast cancer .",epirubicin cyclophosphamide paclitaxel filgrastim are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Those who test positive are treated with combinations of the following agents : omeprazole , clarithromycin , amoxicillin , tetracycline , and metronidazole .",omeprazole clarithromycin amoxicillin tetracycline metronidazole are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? The systemic treatment in both studies consisted of a four-drug-regimen ( VACA = vincristine , actinomycin D , cyclophosphamide , and adriamycin ; or VAIA = vincristine , actinomycin D , ifosfamide , and adriamycin ) and a total number of four courses , each lasting nine weeks , was recommended by the protocol .",vincristine actinomycin cyclophosphamide adriamycin are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Heparin infusion , followed by oral warfarin , is indicated for symptomatic thromboembolic disease as well as for asymptomatic patients with substantial proximal deep venous thrombosis or large pulmonary emboli .",Heparin warfarin are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Fluoxetine and paroxetine are potent inhibitors of CYP2D6 and administration of these SSRIs reduces the clinical benefit of an anticancer drug , such as tamoxifen , by decreasing the formation of active metabolites of this drug .",paroxetine tamoxifen are the drug combinations. No need for context. It is a NEG combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? A total of 460 patients were randomized into four 10-day therapeutic schemes ( 115 patients per group ): ( i ) standard OCA , omeprazole , clarithromycin and amoxicillin ; ( ii ) triple OLA , omeprazole , levofloxacin and amoxicillin ; ( iii ) sequential OACM , omeprazole plus amoxicillin for 5 days , followed by omeprazole plus clarithromycin plus metronidazole for 5 days ; and ( iv ) modified sequential OALM , using levofloxacin instead of clarithromycin .",omeprazole clarithromycin amoxicillin are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Captopril in combination with HYZ significantly reduced BP compared with controls but T replacement increased BP and coronary collagen deposition in spite of HYZ and captopril treatment .,Captopril HYZ are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? Targeted therapy was administered to match the P1K3CA , c-MET , and SPARC and COX2 aberrations with sirolimus+ crizotinib and abraxane+ celecoxib .",sirolimus+ crizotinib are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? EURAMOS-1 results do not support the addition of ifosfamide and etoposide to postoperative chemotherapy in patients with poorly responding osteosarcoma because its administration was associated with increased toxicity without improving event-free survival .,ifosfamide etoposide postoperative chemotherapy are the drug combinations. No need for context. It is a NEG combination.
+drug_combination,What is the drug combination mentioned in the following sentence? These results suggest that the addition of intravenous ceftriaxone during the first 3 days of hospitalization does not improve the cost-efficacy of oral norfloxacin in the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding and high risk of infection .,ceftriaxone norfloxacin are the drug combinations. No need for context. It is a NEG combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? This study evaluated the response rate of the combination therapy of aprinocarsen , gemcitabine , and carboplatin in previously untreated patients with advanced non-small cell lung cancer ( NSCLC ) .",aprinocarsen gemcitabine carboplatin are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? All patients were treated by surgical debridement followed by a combination of antibiotics ; ( ceftazidime , amoxy-clavulanic acid , co-trimoxazole and doxycycline ) for six months except for one who died due to fulminant septicemia .",ceftazidime amoxy-clavulanic co-trimoxazole doxycycline are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? To evaluate the eradication of Helicobacter pylori by therapy with a combination of 60 mg lansoprazole and 800 mg clarithromycin .,lansoprazole clarithromycin are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? All patients were treated with vincristine , doxorubicin , cyclophosphamide and actinomycin-D , alternating with ifosfamide and etoposide every 3 weeks .",vincristine doxorubicin cyclophosphamide actinomycin-D ifosfamide etoposide are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? We studied the combination of pemetrexed , a multi-targeted antifolate , and cetuximab , an mAb against the epidermal growth factor receptor , with radiotherapy in poor prognosis head and neck cancer .",pemetrexed cetuximab are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Boosting darunavir with ritonavir instead of with cobicistat may be preferred if darunavir is to be combined with etravirine in clinical practice .,darunavir ritonavir are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Nal-IRI with 5-fluorouracil ( 5-FU ) and leucovorin or gemcitabine plus cisplatin in advanced biliary tract cancer - the NIFE trial ( AIO-YMO HEP-0315 ),5-fluorouracil leucovorin are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? We conducted a double-blind cross-over study in ten volunteers aged from 19 to 30 years , to compare the pain control effects of a single oral dose of two analgesic compounds ( drug A : propyphenazone mg 250 , ethylmorphine mg 5 , caffeine mg 5 ; drug B : dipyrone mg 500 , diphenhydramine mg 12.5 , adiphenine mg 5 , ethyl aminobenzoate mg 2.5 ) in an experimental pain model using stimulation of dental pulp .",propyphenazone ethylmorphine caffeine are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Furthermore , 11 AML patients at primary diagnosis , including five AML patients with P-gp overexpression , who were treated with idarubicin , vepesid , and cytarabine V ( ara-C ) showed a complete remission .",idarubicin vepesid cytarabine are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Phase Ib Study of Bavituximab With Carboplatin and Pemetrexed in Chemotherapy-Naive Advanced Nonsquamous Non-Small-Cell Lung Cancer .,Bavituximab Carboplatin Pemetrexed are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Such therapy has included weekly paclitaxel in combination with carboplatin/cisplatin plus topotecan , and carboplatin plus doxorubicin .",paclitaxel topotecan carboplatin/cisplatin are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? This phase II study was performed to assess the efficacy and safety of the combination regimen of temozolomide and docetaxel in patients with advanced metastatic melanoma .,temozolomide docetaxel are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Addition of verapamil and tamoxifen to the initial chemotherapy of small cell lung cancer .,verapamil tamoxifen are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Long-term cardiac outcomes of patients with HER2-positive breast cancer treated in the adjuvant lapatinib and/or trastuzumab Treatment Optimization Trial .,lapatinib trastuzumab are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? To determine the current status of ivermectin , abamectin and praziquantel combined , and fenbendazole resistance to Parascaris spp . in horses in Saudi Arabia .",abamectin praziquantel are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? To determine the response rate ( RR ) and survival produced by carboplatin + gemcitabine therapy in patients with untreated extensive small cell lung cancer ( ESCLC ) .,carboplatin gemcitabine are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? The interaction of chloroquine and citalopram in vitro resulted in a synergistic response in the chloroquine-resistant strain but there was no interaction between the drugs in the chloroquine-sensitive strain -- a pattern found with other reversal agents .,chloroquine citalopram are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Interfacial Phenomenon Based Biocompatible Alginate-Chitosan Nanoparticles Containing Isoniazid and Pyrazinamide .,Isoniazid Pyrazinamide are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? In a 27-day inpatient study , 10 methamphetamine-dependent individuals participated in a double-blind , placebo-controlled , cross-over design , with oral doses of topiramate ( 0 , 100 , and 200 mg ) administered as a pretreatment before intravenous doses of methamphetamine ( 0 , 15 , and 30 mg ) .",topiramate methamphetamine are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Synergism between penicillin , clindamycin , or metronidazole and gentamicin against species of the Bacteroides melaninogenicus and Bacteroides fragilis groups .",penicillin clindamycin metronidazole gentamicin are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? In vivo evofosfamide was tumor suppressive as a single agent and cooperated with paclitaxel to reduce mammary tumor growth .,evofosfamide paclitaxel are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Paclitaxel and vinorelbine are among the most active new agents in metastatic breast cancer .,Paclitaxel vinorelbine are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Lenalidomide is currently being tested in combination with both standard and novel agents , including bortezomib , for patients with relapsed/refractory multiple myeloma .",Lenalidomide bortezomib are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? [ Efficacy of fluvoxamine combined with extended-release methylphenidate on treatment-refractory obsessive-compulsive disorder ] .,fluvoxamine methylphenidate are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Analysis of HER Family ( HER1 - 4 ) Expression as a Biomarker in Combination Therapy with Pertuzumab , Trastuzumab and Docetaxel for Advanced HER2-positive Breast Cancer .",Pertuzumab Trastuzumab Docetaxel are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Hepatic arterial infusion of floxuridine and systemic administration of gemcitabine and oxaliplatin .,floxuridine gemcitabine oxaliplatin are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Chemoimmunotherapy with cyclophosphamide , doxorubicin , vincristine , and prednisolone combined with rituximab ( R-CHOP ) is currently the first-line therapy for diffuse large B-cell lymphoma ( DLBCL ) .",cyclophosphamide doxorubicin vincristine prednisolone rituximab are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Cystoid Macular Edema during Treatment with Paclitaxel and Bevacizumab in a Patient with Metastatic Breast Cancer : A Case Report and Literature Review .,Paclitaxel Bevacizumab are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? The results suggest that third-line chemotherapy with combined bevacizumab and S-1 is safe and may delay the progression of mCRC resistant to oxaliplatin and irinotecan with mutated KRAS .,bevacizumab S-1 are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? In the comparison between rivaroxaban-based triple therapy and ticagrelor + aspirin , the RR was 1 and its 95 % CI remained within a post-hoc margin of ± 15 % .",ticagrelor aspirin are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Maintenance Treatment With Low-Dose Mercaptopurine in Combination With Allopurinol in Children With Acute Lymphoblastic Leukemia and Mercaptopurine-Induced Pancreatitis .,Mercaptopurine Allopurinol are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? An 8-week , randomized , parallel-group , double-blind international trial comparing the once-daily single-pill combination of telmisartan 80 mg and amlodipine 10 mg ( T/A ; n = 352 ) with once-daily amlodipine 10 mg ( A ; n = 354 ) in patients with type 2 diabetes mellitus and stage 1 or 2 hypertension ( systolic BP [ SBP ] > 150 mm Hg ) .",telmisartan amlodipine are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Pharmacokinetic studies evaluating the concurrent use of tenofovir and didanosine have been performed in healthy volunteers .,tenofovir didanosine are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Additionally , the combined effect of Lapatinib together with Herceptin or Cetuximab on cell-mediated cytotoxicity was evaluated .",Lapatinib Herceptin are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? In a case-control study , we compared 52 consecutive patients undergoing isolated CABG on aspirin and clopidogrel 75mg/d versus 50 controls on aspirin monotherapy .",aspirin clopidogrel are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? This three-phase study was designed to determine if a pharmacokinetic drug-drug interaction exists between zidovudine and oxazepam .,zidovudine oxazepam are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Additional results from MTT cell viability assays demonstrated that H1975 cell proliferation was not significantly decreased after Wnt inhibition by XAV939 , but combination treatment with everolimus ( mTOR inhibitor ) and erlotinib resulted in synergistic cell growth inhibition .",XAV939 everolimus are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? The addition of dexmedetomidine to bupivacaine 0.5 % in EUS-CPN demonstrated beneficial effects as regards the degree and duration of pain relieve with negligible effect on the patient survival .,dexmedetomidine bupivacaine are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? The incidence of carcinoma , confirmed microscopically , was : control 14/20 ( 70 % ) ; high-dose gefitinib , 7/20 ( 35 % ) ; low-dose gefitinib , 7/20 ( 35 % ) ; high-dose meloxicam 7/21 ( 33 % ) ; and low-dose meloxicam , 12/20 ( 60 % ) .",gefitinib meloxicam are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Patients with incurable cancer causing chronic pain rated above 6/10 on a numerical scale while receiving high-dose opioid therapy ( more than 200 mg/d of oral morphine equivalent ) and/or exhibiting severe opioid-related adverse events received intrathecal infusions of ziconotide combined with morphine , ropivacaine , and clonidine .",ziconotide morphine ropivacaine clonidine are the drug combinations. No need for context. It is a NEG combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? Combination chemotherapy with gemcitabine ( Gem ) , doxorubicin ( Dox ) , and paclitaxel ( Pac ) ( GAT ) has been considered attractive as first-line treatment in metastatic breast cancer .",gemcitabine doxorubicin paclitaxel are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? Imipenem was compared with nafcillin and with penicillin plus gentamicin in the therapy of experimental endocarditis induced in rabbits by Staph . aureus and Str . faecalis , respectively .",penicillin gentamicin are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? The total dose of paclitaxel ( 175 - 200 mg/m2 ) ; cisplatin ( 75 mg/m2 ) ; and etoposide ( 175 - 200 mg/m2 ) was divided into five daily doses administered over 3 h with cycles repeated at 21 - 28 days .,paclitaxel cisplatin etoposide are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? In this phase 3 trial , we randomly assigned ( in a 1:1:1 ratio ) patients with advanced renal cell carcinoma and no previous systemic therapy to receive lenvatinib ( 20 mg orally once daily ) plus pembrolizumab ( 200 mg intravenously once every 3 weeks ) , lenvatinib ( 18 mg orally once daily ) plus everolimus ( 5 mg orally once daily ) , or sunitinib ( 50 mg orally once daily , alternating 4 weeks receiving treatment and 2 weeks without treatment ) .",lenvatinib pembrolizumab are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Only chemotherapy by intravenous administration of 2 courses of 120 - 150 mg ACNU ( 1.7 - 2.2 mg/kg ) and 4 mg vincristine ( 0.06 mg/kg ) with intrathecal administration of methotrexate was given at this time .,ACNU vincristine methotrexate are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? In first-line treatment of intermediate- to poor-risk patients , the CheckMate 214 study demonstrated a significant survival advantage for nivolumab and ipilimumab versus sunitinib .",nivolumab ipilimumab are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Lapatinib ( LPT ) could sensitize human epidermal growth factor receptor-2 ( HER-2 ) positive breast cancer to paclitaxel ( PTX ) and induce synergetic action with PTX in preclinical test and phase II/III trial .,Lapatinib paclitaxel are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? Two of nine patients received 15 mg/kg bevacizumab IV , 90 mg/m(2 ) irinotecan orally for five consecutive days , 100 mg/m(2)/day temozolomide IV for 5 days , and 1.5 mg/m(2 ) vincristine IV , each administered every 21 days .",bevacizumab irinotecan temozolomide vincristine are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? These findings may help clinicians identify patients for whom acamprosate and naltrexone may be most beneficial .,acamprosate naltrexone are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? From August 2002 to August 2004 , 42 patients with metastatic breast cancer were recruited for treatment with pegylated liposomal doxorubicin 40 mg/m(2 ) intravenously ( i.v . ) on day 1 and vinorelbine 30 mg/m(2 ) i.v . on days 1 and 15 every 4 weeks .",doxorubicin vinorelbine are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? The aim of the present study was to investigate the combined effects of simvastatin and exemestane on MCF-7 human breast cancer cells .,simvastatin exemestane are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Synergy of Omeprazole and Praziquantel In Vitro Treatment against Schistosoma mansoni Adult Worms .,Omeprazole Praziquantel are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Inclusion criteria were proven infection with evidence of a bacterial strain of PA resistant to all β-lactams and treated with the association of at least aztreonam plus cefepime .,aztreonam cefepime are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Comparison of the additive effects of nipradilol and carteolol to latanoprost in open-angle glaucoma .,carteolol latanoprost are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Fluvoxamine is a fairly potent inhibitor of CYP2C19 and it has the potential for causing drug-drug interactions with substrates for CYP2C19 such as imipramine , clomipramine , amitriptyline and diazepam .",Fluvoxamine imipramine are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? The combinations of irinotecan and mitomycin C or oxaliplatin have given very good results with high objective response rates and good tolerance .,irinotecan mitomycin are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? In the second study 12 patients with small cell undifferentiated cancers were treated with carboplatin , etoposide and ifosfamide .",carboplatin etoposide ifosfamide are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? 3 . Systemic ( i.v . ) pretreatment with furosemide ( 2 - 10 mg kg-1 ) increased urine volume and dose-dependently inhibited the pressor response to i.c.v . clonidine ( 10 micrograms ) , and a long-lasting depressor response to clonidine was observed .",furosemide clonidine are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Nine studies connected to the network for the PFS analysis in which necitumumab in combination with gemcitabine and cisplatin was associated with the lowest HR .,necitumumab gemcitabine cisplatin are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? To evaluate the efficacy and toxicities of gemcitabine combined with ifosfamide and anthracycline chemotherapy for recurrent platinum resistant ovarian epithelial cancer .,gemcitabine ifosfamide anthracycline are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Combination of erlotinib and sorafenib , synergistic in GSC11 , induced apoptosis and autophagic cell death associated with suppressed Akt and ERK signaling pathways and decreased nuclear PKM2 and β-catenin in vitro , and tended to improve survival of nude mice bearing GSC11 brain tumor .",erlotinib sorafenib are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? In the first trial , paclitaxel and doxorubicin were alternated every 3 weeks in doses of 200 mg/m2 and 75 mg/m2 , respectively , for patients who had received no more than one prior chemotherapeutic regimen .",paclitaxel doxorubicin are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Thirty-one patients with histologically proven small cell lung cancer were treated with cyclophosphamide 1 g m-2 and etoposide ( VP16 - 213 ) 125 mg m-2 both intravenously on day 1 followed by etoposide 250 mg m-2 orally on days 2 - 3 for a maximum of six courses at 3 weekly intervals .,cyclophosphamide etoposide are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Pemetrexed plus carboplatin followed by pemetrexed , docetaxel , atezolizumab and S-1 were performed in sequence .",Pemetrexed carboplatin pemetrexed docetaxel atezolizumab are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? The aim of this phase I study was to determine the maximum tolerated dose of a 3-h infusion of paclitaxel , combined with carboplatin at a fixed AUC of 7 mg ml-1 min every 4 weeks for up to six cycles and to evaluate any possible pharmacokinetic interaction .",paclitaxel carboplatin are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Efficacy of tramadol in combination with doxepin or venlafaxine in inhibition of nociceptive process in the rat model of neuropathic pain : an isobolographic analysis .,tramadol doxepin are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? All those treated with mefloquine plus artemether survived and their parasite clearance time and fever clearance time were significantly shorter than those of patients receiving quinine .,mefloquine artemether are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? In the present study , we evaluated the efficacy and safety of the weekly combination of etoposide , leucovorin ( LV ) and 5-fluorouracil ( 5-FU ) when administered as second-line chemotherapy in patients with relapsed/refractory advanced colorectal cancer ( ACC ) , previously treated with weekly LV+5-FU .",etoposide leucovorin 5-fluorouracil are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Diazoxide , nifedipine and 2-deoxy glucose suppressed ( p < 0.05 ) glucose stimulated insulin secretion in AtT20HI-GLUT2-GK-6 cells .",Diazoxide nifedipine 2-deoxy glucose are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Reducing the duration of medication use postoperatively may also minimize the possible side effects of ketorolac and codeine , which could develop with extended periods of use .",ketorolac codeine are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Lenalidomide plus dexamethasone is a reference treatment for relapsed multiple myeloma .,Lenalidomide dexamethasone are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? The authors report on anemia observed during preoperative paclitaxel and carboplatin chemotherapy in patients with advanced head and neck carcinoma and discuss how the use of recombinant human erythropoietin ( r-HuEPO ) ameliorates this anemia , reducing the need for subsequent packed red blood cell ( PRBC ) transfusions .",paclitaxel carboplatin erythropoietin are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Combination therapy with fluconazole and flucytosine in the murine model of cryptococcal meningitis .,fluconazole flucytosine are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? After successful phase II studies , recent phase III trials established combinations of chlorambucil with anti-CD20 antibodies such as rituximab , ofatumumab and obinutuzumab as a valuable treatment option for these patients .",chlorambucil rituximab are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Randomized Trial of Lenalidomide Alone Versus Lenalidomide Plus Rituximab in Patients With Recurrent Follicular Lymphoma : CALGB 50401 ( Alliance ) .,Lenalidomide Rituximab are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Treatments included once daily erlotinib , which was given alone for the first 7 days of treatments , then in combination with once daily sirolimus .",erlotinib sirolimus are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? The results suggest that rational therapy for severe CHF includes addition of the aldosterone antagonist spironolactone to low doses of captopril ( or another ACE inhibitor ) and high doses of loop diuretics , provided renal function is adequate .",spironolactone captopril loop diuretics are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? Combination therapy of infliximab and methotrexate is more effective in reducing clinical and biochemical disease activity than gold with methylprednisolone treatment in RA patients during 22 weeks of treatment , especially in the first 6 weeks .",infliximab methotrexate are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? Serum homocysteine , cholesterol , retinol , alpha-tocopherol , glycosylated hemoglobin and inflammatory response during therapy with bevacizumab , oxaliplatin , 5-fluorouracil and leucovorin .",bevacizumab oxaliplatin 5-fluorouracil leucovorin are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Reversal of drug resistance by planetary ball milled ( PBM ) nanoparticle loaded with resveratrol and docetaxel in prostate cancer .,resveratrol docetaxel are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? Records of 63 patients diagnosis of IHCC who received Gemcitabine and Carboplatin ( G-C Regimen ) chemotherapy as a first line were retrospectively reviewed .,Gemcitabine Carboplatin are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? Drugs most commonly implicated in ADRs were amoxicillin + clavulanate ( 21.87 % ) followed by ceftriaxone ( 20.31 % ) .,amoxicillin clavulanate are the drug combinations. No need for context. It is a NEG combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? Dexamethasone and piroxicam provided in the diet were found to significantly inhibit lung tumors induced by 60 mg/kg vinyl carbamate at 24 weeks whereas myo-inositol also provided in the diet , did not significantly inhibit tumor formation .",Dexamethasone piroxicam are the drug combinations. No need for context. It is a POS combination.
+drug_combination,What is the drug combination mentioned in the following sentence? The NIBIT-MESO-1 study demonstrated the efficacy and safety of tremelimumab combined with durvalumab in patient with unresectable mesothelioma followed up for a median of 52 months [ IQR 49 - 53 ] .,tremelimumab durvalumab are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? The addition of trastuzumab , pertuzumab , bevacizumab , or lapatinib to chemotherapy significantly ( P < .05 ) improved objective response rate ( ORR ) , time to failure ( TTF ) , and overall survival ( OS ) in patients with HER2-positive ( HER2(+ ) ) disease .",trastuzumab chemotherapy are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? The feasibility and efficacy of an intensified procarbazine-free consolidation regimen VECOPA ( vinblastine , etoposide , cyclophosphamide , vincristine , prednisone , doxorubicin ) were investigated .",vinblastine etoposide cyclophosphamide vincristine prednisone doxorubicin are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? The combination regimen of nivolumab plus ipilimumab demonstrates activity in metastatic uveal melanoma , with deep and sustained confirmed responses .",nivolumab ipilimumab are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? The FDA reviewed data in electronic format from a randomized controlled clinical trial of 1106 adult patients with newly diagnosed Philadelphia chromosome-positive CML in chronic phase , comparing imatinib with the combination of IFN-alpha and cytarabine .",cytarabine IFN-alpha are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? A total of 164 patients with recurrent ovarian cancer were selected and randomly divided into two groups : experimental group ( n=82 , BEV + paclitaxel + carboplatin ) and control group ( n=82 , paclitaxel + carboplatin ) .",paclitaxel carboplatin BEV are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? Successful treatment of an adult with Kasabach-Merritt syndrome using thalidomide , vincristine , and prednisone .",thalidomide vincristine prednisone are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? Profiling of drug-metabolizing enzymes/transporters in CD33 + acute myeloid leukemia patients treated with Gemtuzumab-Ozogamicin and Fludarabine , Cytarabine and Idarubicin .",Fludarabine Cytarabine Idarubicin Gemtuzumab-Ozogamicin are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? To determine efficacy and safety of the association of IL-1 receptor antagonist anakinra plus methylprednisolone in severe COVID-19 pneumonia with hyperinflammation .,anakinra methylprednisolone are the drug combinations. Need more context.
+drug_combination,"What is the drug combination mentioned in the following sentence? When rats were given Li for 3 days , followed by a single injection of imipramine , the concentrations of desipramine in the brain and serum were higher than those in the vehicle-treated rat , although the imipramine concentrations in both tissues did not differ in Li- and in vehicle-treated rats .",Li imipramine are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? In the present study the combination of tamoxifen and bromocriptine was tried for the suppression of prolactin in prolactin secreting adenomas which were resistant to suppression with bromoergocriptine alone .,tamoxifen bromocriptine are the drug combinations. Need more context.
+drug_combination,What is the drug combination mentioned in the following sentence? The present case suggests that combination therapy with thalidomide and dexamethasone is still an alternative treatment regimen for resistant extramedullary plasmacytoma with a plasmablastic morphology .,thalidomide dexamethasone are the drug combinations. No need for context. It is a POS combination.
+drug_combination,"What is the drug combination mentioned in the following sentence? Among 788 eligible patients , the median ( SD ) age was 59 ( 22 - 74 ) years ; 263 patients were assigned to doxorubicin plus cisplatin treatment , 263 patients to docetaxel plus cisplatin treatment , and 262 patients to paclitaxel plus carboplatin treatment .",doxorubicin cisplatin are the drug combinations. Need more context.