What is renal compensation?

Renal compensation is a mechanism by which the kidneys can regulate the plasma pH. It is slower than respiratory compensation, but has a greater ability to restore normal values. Kidneys maintain the acid-base balance through two mechanisms,- the secretion of H+ ions and the reabsorption of bicarbonate HCO3 from urine which is then released into the blood.[1] The regulation of H+ ions and bicarbonate HCO3 is determined by the concentration of the two released within the urine.[2] These mechanisms of secretion and reabsorption balance the pH of the bloodstream.[3] A restored acid-base balanced bloodstream thus leads to a restored acid-base balance throughout the entire body.

Renal compensation is the mechanism that the kidneys use to regulate plasma pH. It is a slower process than respiratory compensation, but increases the body's ability to restore normal values.