ahmedabdelwahed/Medical_papers_title_and_abstract_NLP_dataset huggingface dataset:
Minimum phase finite impulse response filter design

The design of minimum phase finite impulse response (FIR) filters is considered. The study demonstrates that the residual errors achieved by current state-of-the-art design methods are nowhere near the smallest error possible on a finite resolution digital computer. This is shown to be due to conceptual errors in the literature pertaining to what constitutes a factorable linear phase filter. This study shows that factorisation is possible with a zero residual error (in the absence of machine finite resolution error) if the linear operator or matrix representing the linear phase filter is positive definite. Methodology is proposed able to design a minimum phase filter that is optimal-in the sense that the residual error is limited only by the finite precision of the digital computer, with no systematic error. The study presents practical application of the proposed methodology by designing two minimum phase Chebyshev FIR filters. Results are compared to state-of-the-art methods from the literature, and it is shown that the proposed methodology is able to reduce currently achievable residual errors by several orders of magnitude.
ARID1A, BRG1, and INI1 deficiency in undifferentiated and dedifferentiated endometrial carcinoma: a clinicopathologic, immunohistochemical, and next-generation sequencing analysis of a case series from a single institution

Undifferentiated/dedifferentiated endometrial carcinomas (UDEC and DDEC) are rare, aggressive uterine neoplasms, with no specific line of differentiation. A significant proportion of these cases feature mutations of SWI/SNF chromatin remodeling complex members, including ARID1A, SMARCA4, and SMARCB1 genes. To study these entities more comprehensively, we identified 10 UDECs and 10 DDECs from our pathology archives, obtained clinicopathologic findings and follow-up data, and performed immunohistochemical studies for ARID1A, BRG1 (SMARCA4), and INI1 (SMARCB1) proteins. In addition, we successfully conducted targeted next-generation sequencing for 23 samples, including 7 UDECs, and 7 undifferentiated and 9 well/moderately-differentiated components of DDECs. Cases consisted of 18 hysterectomies and 2 curettage/biopsy specimens. Patient age ranged from 47 to 77 years (median, 59 years), with a median tumor size of 8.0 cm (range, 2.5-13.0 cm). All cases demonstrated lymphovascular invasion and the majority (13/20) were FIGO stage III-IV. By immunohistochemistry, ARID1A loss was observed in 15 cases, BRG1 loss in 4, and all cases had intact INI1 expression. A trend for enrichment of the undifferentiated component of DDECs for ARID1A loss was seen, although not statistically significant. Sequencing revealed frequent pathogenic mutations in PTEN, PIK3CA, ARID1A, CTNNB1, and RNF43, a recurrent MAX pathogenic mutation, and MYC and 12p copy number gains. In DDECs, the undifferentiated component featured a higher tumor mutational burden compared to the well/moderately-differentiated component; however, the mutational landscape largely overlapped. Overall, our study provides deep insights into the mutational landscape of UDEC/DDEC, SWI/SNF chromatin remodeling complex member status, and their potential relationships with tumor features.
Compensatory Genetic and Transcriptional Cytonuclear Coordination in Allopolyploid Lager Yeast (Saccharomyces pastorianus)

Cytonuclear coordination between biparental-nuclear genomes and uniparental-cytoplasmic organellar genomes in plants is often resolved by genetic and transcriptional cytonuclear responses. Whether this mechanism also acts in allopolyploid members of other kingdoms is not clear. Additionally, cytonuclear coordination of interleaved allopolyploid cells/individuals within the same population is underexplored. The yeast Saccharomyces pastorianus provides the opportunity to explore cytonuclear coevolution during different growth stages and from novel dimensions. Using S. pastorianus cells from multiple growth stages in the same environment, we show that nuclear mitochondria-targeted genes have undergone both asymmetric gene conversion and growth stage-specific biased expression favoring genes from the mitochondrial genome donor (Saccharomyces eubayanus). Our results suggest that cytonuclear coordination in allopolyploid lager yeast species entails an orchestrated and compensatory genetic and transcriptional evolutionary regulatory shift. The common as well as unique properties of cytonuclear coordination underlying allopolyploidy between unicellular yeasts and higher plants offers novel insights into mechanisms of cytonuclear evolution associated with allopolyploid speciation.
Endoscopic Medial Orbitotomy for Lateral Access to Anterior Cranial Base Pathology

This article showcases a technique to further expand the endoscopic endonasal approach to the skull base by traversing the orbit for further lateral exposure. Laryngoscope, 133:1336-1338, 2023.
Conditional Deletion of KOR (Oprk1) in Kisspeptin Cells Does Not Alter LH Pulses, Puberty, or Fertility in Mice

Classic pharmacological studies suggested that endogenous dynorphin-KOR signaling is important for reproductive neuroendocrine regulation. With the seminal discovery of an interconnected network of hypothalamic arcuate neurons co-expressing kisspeptin, neurokinin B, and dynorphin (KNDy neurons), the KNDy hypothesis was developed to explain how gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) pulses are generated. Key to this hypothesis is dynorphin released from KNDy neurons acting in a paracrine manner on other KNDy neurons via kappa opioid receptor (KOR) signaling to terminate neural "pulse" events. While in vitro evidence supports this aspect of the KNDy hypothesis, a direct in vivo test of the necessity of KOR signaling in kisspeptin neurons for proper LH secretion has been lacking. We therefore conditionally knocked out KOR selectively from kisspeptin neurons of male and female mice and tested numerous reproductive measures, including in vivo LH pulse secretion. Surprisingly, despite validating successful knockout of KOR in kisspeptin neurons, we found no significant effect of kisspeptin cell-specific deletion of KOR on any measure of puberty, LH pulse parameters, LH surges, follicle-stimulating hormone (FSH) levels, estrous cycles, or fertility. These outcomes suggest that the KNDy hypothesis, while sufficient normally, may not be the only neural mechanism for sculpting GnRH and LH pulses, supported by recent findings in humans and mice. Thus, besides normally acting via KOR in KNDy neurons, endogenous dynorphin and other opioids may, under some conditions, regulate LH and FSH secretion via KOR in non-kisspeptin cells or perhaps via non-KOR pathways. The current models for GnRH and LH pulse generation should be expanded to consider such alternate mechanisms.
Developing ecotourism sustainability maximization (ESM) model: a safe minimum standard for climate change mitigation in the Indian Himalayas

Recently, ecotourism has been identified as an adaptation strategy for mitigating climate change impacts, as it can optimize carbon sequestration, biodiversity recovery, and livelihood benefits and generate new opportunities for the sustenance of the economy, environment, and society of the area endowed with natural resources and cultural values. With the growing responsibility at the global level, ecotourism resource management (ERM) becomes inevitable for its sustainable requirements. The integration of ecological and socio-economic factors is vital for ERM, as has been demonstrated by developing an Ecotourism Sustainability Maximization Model for an area under study, that is the Yuksam-Dzongri corridor (also known as Kangchendzonga Base Camp Trek), in the Khangchendzonga Biosphere Reserve (KBR), Sikkim, India. This model is based on the earlier developed ecotourism sustainability assessment (ESA) framework by the authors, which is based on the hierarchical relationship among ecotourism principles, criteria, indicators, and verifiers. Employing such relationships, this paper attempts to maximize ecotourism sustainability (ES) as a function of its sustainability principles, criteria, indicators, and verifiers, subject to the constraints identified through the safe minimum standard (SMS) approach by employing linear programming. Using 58 indicators as decision variables and 114 constraints, the model resulted in a maximum level of achievable ES with a score of 84.6%, allowing the resultant optimum values of the indicators to be maintained at the operational level. A central tenet of the model is the collective responsibility and adoption of a holistic approach involving the government, tourists, tourism enterprises, and local people.
Multi-fusion feature pyramid for real-time hand detection

Real-time HI (Human Interface) systems need accurate and efficient hand detection models to meet the limited resources in budget, dimension, memory, computing, and electric power. The detection task is also important for other applications such as homecare systems, fine-grained action recognition, movie interpretation, and even for understanding dance gestures. In recent years, object detection has become a less challenging task with the latest deep CNN-based state-of-the-art models, i.e., RCNN, SSD, and YOLO. However, these models cannot achieve desired efficiency and accuracy on HI-based embedded devices due to their complex time-consuming architecture. Another critical issue in hand detection is that small hands (<30 x 30 pixels) are still challenging for all the above methods. We proposed a shallow model named Multi-fusion Feature Pyramid for real-time hand detection to deal with the above problems. Experimental results on the Oxford hand dataset combined with the skin dataset show that the proposed method outperforms other SoTA methods in terms of accuracy, efficiency, and real-time speed. The COCO dataset is also used to compare with other state-of-the-art method and shows the highest efficiency and accuracy with the proposed CFPN model. Thus we conclude that the proposed model is useful for real-life small hand detection on embedded devices.
A 30 Gb/s/Link 2.2 Tb/s/mm(2) Inductively-Coupled Injection-Locking CDR for High-Speed DRAM Interface

This paper presents a 30 Gb/s/link 2.2 Tb/s/mm(2) inductive-coupling link for a high-speed DRAM interface. The data rate per layout area is the highest among DRAM interfaces reported up to now. The proposed interface employs a high-speed injection-locking CDR technique that utilizes the derivative property of inductive coupling. Compared to conventional injection-locking CDR based on an XOR edge detector, the proposed technique doubles the operation speed and increases the data rate to 30 Gb/s/link. As a result, the data rate per layout area is increased to 2.2 Tb/s/mm(2), which is 2X that of the state-of-the-art inductive-coupling link, and 22X that of the state-of-the-art wired link.
CRY2 gene of rice (Oryza sativa subsp. indica) encodes a blue light sensory receptor involved in regulating flowering, plant height and partial photomorphogenesis in dark

OsiCRY2 is involved in light-regulated plant development and plays a role in regulating photomorphogenesis, plant height, flowering and most strikingly partial photomorphogenesis in dark. Cryptochrome 2 (CRY2), the blue/UV-A light photoreceptor in plants, has been reported to regulate photoperiod-dependent flowering and seedling photomorphogenesis (under low-intensity light). Among monocots, CRY2 has been reported from japonica rice, wheat, sorghum and barley. The two sub-species of rice, indica and japonica, exhibit a high degree of genetic variation and morphological and physiological differences. This article describes the characterization of CRY2 of indica rice (OsiCRY2). While the transcript levels of OsiCRY2 did not change significantly under blue light, its protein levels were found to decline with increased time duration under blue light. For phenotypic characterization, OsiCRY2 over-expression (OX) transgenics were generated in Oryza sativa Pusa Sugandh 2 (PS2) cultivar, a highly scented Basmati cultivar. The OsiCRY2OX transgenics displayed shorter coleoptiles and dwarfism than wild-type under blue light, white, and far-red light. Interestingly, even the dark-grown transgenics were shorter, concomitant with higher OsiCRY2 protein levels in transgenics than wild-type. Histological analysis revealed that the decrease in the length of the seedlings was due to a decrease in the length of the epidermal cells. The fully mature rice transgenics were shorter than the untransformed plants but flowered at the same time as wild-type. However, the OsiCRY2 Arabidopsis over-expressors exhibited early flowering by 10-15 days, indicating the potential and conservation of function of OsiCRY2. The whole-genome transcriptome profiling of rice transgenics revealed the differential up-regulation of several light-regulated genes in dark-grown coleoptiles. These data provide evidence that OsiCRY2 regulates photomorphogenesis, plant height, and flowering in indica rice.
Treatment of copper nanoparticles (CuNPs) for two spermatogenic cycles impairs testicular activity via down-regulating steroid receptors and inhibition of germ cell proliferation in a mice model

Although copper is an indispensable trace metal for biological functions, its excess exposure causes hazardous effects on health. Copper in the form of nanoparticles (CuNPs) is widely used at present and therefore, the living organism is at continuous risk of its adverse effect. The prolonged treatment of CuNPs has not been evaluated yet on the male reproductive system. To demonstrate the combined adverse effects and the mechanism of copper nanoparticles (CuNPs), three doses of CuNPs, 10, 100 and 200 mg/kg were orally given to mice for 70 days. The present study demonstrated that CuNPs decreased the sperm quality parameters, male circulating hormones, induces testicular damages, increased oxidative stress, apoptosis, decreases antioxidant enzymes, germ cell proliferation, and increases the expression of 8-oxoguanine DNA glycosylase-1 (OGG1), apelin receptor (APJ) as well. CuNPs also down-regulated the expression of AR and Erα in the testis. These results suggest that CuNPs manifested their adverse effect on testis via modulating steroid and cytokine (apelin) receptors. The adverse effect of testis was most pronounced at the highest dose (200 mg/kg) of CuNPs, however, other doses show a less toxic effect on various parameters. In conclusion, results indicated that CuNPs may impair spermatogenesis via oxidative stress-mediated DNA damage and germ cell apoptosis at high doses.
Zero-point attracting projection algorithm for sequential compressive sensing

Sequential Compressive Sensing, which may be widely used in sensing devices, is a popular topic of recent research. This paper proposes an online recovery algorithm for sparse approximation of sequential compressive sensing. Several techniques including warm start, fast iteration, and variable step size are adopted in the proposed algorithm to improve its online performance. Finally, numerical simulations demonstrate its better performance than the relative art.
Coronary computed tomography angiography-based endothelial wall shear stress in normal coronary arteries

Endothelial wall shear stress (ESS) is a biomechanical force which plays a role in the formation and evolution of atherosclerotic lesions. The purpose of this study is to evaluate coronary computed tomography angiography (CCTA)-based ESS in coronary arteries without atherosclerosis, and to assess factors affecting ESS values. CCTA images from patients with suspected coronary artery disease were analyzed to identify coronary arteries without atherosclerosis. Minimal and maximal ESS values were calculated for 3-mm segments. Factors potentially affecting ESS values were examined, including sex, lumen diameter and distance from the ostium. Segments were categorized according to lumen diameter tertiles into small (< 2.6 mm), intermediate (2.6-3.2 mm) or large (≥ 3.2 mm) segments. A total of 349 normal vessels from 168 patients (mean age 59 ± 9 years, 39% men) were included. ESS was highest in the left anterior descending artery compared to the left circumflex artery and right coronary artery (minimal ESS 2.3 Pa vs. 1.9 Pa vs. 1.6 Pa, p < 0.001 and maximal ESS 3.7 Pa vs. 3.0 Pa vs. 2.5 Pa, p < 0.001). Men had lower ESS values than women, also after adjusting for lumen diameter (p < 0.001). ESS values were highest in small segments compared to intermediate or large segments (minimal ESS 3.8 Pa vs. 1.7 Pa vs. 1.2 Pa, p < 0.001 and maximal ESS 6.0 Pa vs. 2.6 Pa vs. 2.0 Pa, p < 0.001). A weak to strong correlation was found between ESS and distance from the ostium (ρ = 0.22-0.62, p < 0.001). CCTA-based ESS values increase rapidly and become widely scattered with decreasing lumen diameter. This needs to be taken into account when assessing the added value of ESS beyond lumen diameter in highly stenotic lesions.
Blocking postsynaptic density-93 binding to C-X3-C motif chemokine ligand 1 promotes microglial phenotypic transformation during acute ischemic stroke

We previously reported that postsynaptic density-93 mediates neuron-microglia crosstalk by interacting with amino acids 357-395 of C X3 C motif chemokine ligand 1 (CX3CL1) to induce microglia polarization. More importantly, the peptide Tat-CX3CL1 (comprising amino acids 357-395 of CX3CL1) disrupts the interaction between postsynaptic density-93 and CX3CL1, reducing neurological impairment and exerting a protective effect in the context of acute ischemic stroke. However, the mechanism underlying these effects remains unclear. In the current study, we found that the pro-inflammatory M1 phenotype increased and the anti-inflammatory M2 phenotype decreased at different time points. The M1 phenotype increased at 6 hours after stroke and peaked at 24 hours after perfusion, whereas the M2 phenotype decreased at 6 and 24 hours following reperfusion. We found that the peptide Tat-CX3CL1 (357-395aa) facilitates microglial polarization from M1 to M2 by reducing the production of soluble CX3CL1. Furthermore, the a disintegrin and metalloprotease domain 17 (ADAM17) inhibitor GW280264x, which inhibits metalloprotease activity and prevents CX3CL1 from being sheared into its soluble form, facilitated microglial polarization from M1 to M2 by inhibiting soluble CX3CL1 formation. Additionally, Tat-CX3CL1 (357-395aa) attenuated long-term cognitive deficits and improved white matter integrity as determined by the Morris water maze test at 31-34 days following surgery and immunofluorescence staining at 35 days after stroke, respectively. In conclusion, Tat-CX3CL1 (357-395aa) facilitates functional recovery after ischemic stroke by promoting microglial polarization from M1 to M2. Therefore, the Tat-CX3CL1 (357-395aa) is a potential therapeutic agent for ischemic stroke.
Single-Track Vehicle Dynamics Control: State of the Art and Perspective

The reduction of hardware costs and the availability of smaller, lighter electromechanical actuators have led to the development of numerous control systems for powered two wheelers (PTW). Although the community working on PTW dynamics control is smaller than the community addressing automotive control, a considerable number of contributions are available. This paper presents a review on the control of PTW, and anticipates future research and industrial trends. This paper proposes a reasoned classification of different approaches based on the controlled vehicle dynamics, separating between control systems dealing with the in-plane and out-of-plane dynamics and then presents an analysis of the state-of-the-art of each control problem. A section is then devoted to the control of narrow track tilting vehicles that share many features with PTW.
Understanding the salinity stress on plant and developing sustainable management strategies mediated salt-tolerant plant growth-promoting rhizobacteria and CRISPR/Cas9

Soil salinity is a worldwide concern that decreases plant growth performance in agricultural fields and contributes to food scarcity. Salt stressors have adverse impacts on the plant's ionic, osmotic, and oxidative balance, as well as numerous physiological functions. Plants have a variety of coping strategies to deal with salt stress, including osmosensing, osmoregulation, ion-homeostasis, increased antioxidant synthesis, and so on. Not only does salt stress cause oxidative stress but also many types of stress do as well, thus plants have an effective antioxidant system to battle the negative effects of excessive reactive oxygen species produced as a result of stress. Rising salinity in the agricultural field affects crop productivity and plant development considerably; nevertheless, plants have a well-known copying mechanism that shields them from salt stress by facilitated production of secondary metabolites, antioxidants, ionhomeostasis, ABAbiosynthesis, and so on. To address this problem, various environment-friendly solutions such as salt-tolerant plant growth-promoting rhizobacteria, eco-friendly additives, and foliar applications of osmoprotectants/antioxidants are urgently needed. CRISPR/Cas9, a new genetic scissor, has recently been discovered to be an efficient approach for reducing salt stress in plants growing in saline soil. Understanding the processes underlying these physiological and biochemical responses to salt stress might lead to more effective crop yield control measures in the future. In order to address this information, the current review discusses recent advances in plant stress mechanisms against salinity stress-mediated antioxidant systems, as well as the development of appropriate long-term strategies for plant growth mediated by CRISPR/Cas9 techniques under salinity stress.
Cross clamping of the supraceliac aorta is effective for bleeding control in ruptured giant splenic artery pseudoaneurysm when proximal and distal control of the splenic artery is not possible: a case report

Splenic artery pseudoaneurysm is the most common of all the visceral artery pseudoaneurysms. Presentation is often variable and the condition demands immediate diagnosis and management because pseudoaneurysm rupture increases morbidity and mortality. It is associated with pancreatitis and other conditions like abdominal trauma, chronic pancreatitis, pseudocyst of the pancreas, liver transplantation, and, rarely, peptic ulcer disease. We present a case of a giant splenic artery pseudoaneurysm measuring 14x8 cm. Proximal and distal control of the vessels could not be achieved during the procedure because of local adhesions and inflammation and it was necessary to cross clamp the supraceliac aorta to control bleeding.
Hyperspectral Multispectral Image Fusion via Fast Matrix Truncated Singular Value Decomposition

Recently, methods for obtaining a high spatial resolution hyperspectral image (HR-HSI) by fusing a low spatial resolution hyperspectral image (LR-HSI) and high spatial resolution multispectral image (HR-MSI) have become increasingly popular. However, most fusion methods require knowing the point spread function (PSF) or the spectral response function (SRF) in advance, which are uncertain and thus limit the practicability of these fusion methods. To solve this problem, we propose a fast fusion method based on the matrix truncated singular value decomposition (FTMSVD) without using the SRF, in which our first finding about the similarity between the HR-HSI and HR-MSI is utilized after matrix truncated singular value decomposition (TMSVD). We tested the FTMSVD method on two simulated data sets, Pavia University and CAVE, and a real data set wherein the remote sensing images are generated by two different spectral cameras, Sentinel 2 and Hyperion. The advantages of FTMSVD method are demonstrated by the experimental results for all data sets. Compared with the state-of-the-art non-blind methods, our proposed method can achieve more effective fusion results while reducing the fusing time to less than 1% of such methods; moreover, our proposed method can improve the PSNR value by up to 16 dB compared with the state-of-the-art blind methods.