ahmedabdelwahed/Medical_papers_title_and_abstract_NLP_dataset huggingface dataset:
Interventional radiology in renal emergencies: a pictorial essay

Renal emergencies necessitate prompt diagnosis and management to stop active bleeding and retain kidney function. Causes of renal emergencies can be classified into traumatic, atraumatic, iatrogenic, and obstructive etiologies. Interventional radiology (IR) has emerged as an acceptable alternative to surgical treatment in the management of renal emergencies due to its minimally invasive nature. With the rise of interventional procedures, there is a need for further discussion of angiographic and fluoroscopic imaging in the setting of renal emergencies.
Suppression of Wnt Expression by Increasing PI3K in Rats Cervical Carcinoma by Andaliman ( Zanthoxylum acanthopodium)

&lt;b&gt;Background and Objective:&lt;/b&gt; Cervical cancer is the leading cause of death for women in the world and Indonesia. This disease originates from a malignant tumour of squamous epithelial cells caused by infection with the Human Papilloma Virus (HPV). Antioxidants can reduce oxidative stress in and there are plants from Indonesia that have high antioxidants, namely andaliman (&lt;i&gt;Zanthoxylum acanthopodium&lt;/i&gt;). This study aimed to analyze the role of andaliman on PI3K and Wnt signalling in cervical cancer histology. &lt;b&gt;Materials and Methods:&lt;/b&gt; The study includes 5 treatments. The control group (K-), rats cancer model (K+), rats cancer model+the dose is 100 mg/b.wt. of ZAM (P&lt;sub&gt;1&lt;/sub&gt;), rats cancer model+the dose is 200 mg/b.wt. of ZAM (P&lt;sub&gt;2&lt;/sub&gt;) and rats cancer model+the dosage is 400 mg/b.wt. ZAM (P&lt;sub&gt;3&lt;/sub&gt;). On the 30th day after ZAM administration, the rats were dissected for the paraffin block and Wnt and PI3K immunohistochemical staining was prepared. &lt;b&gt;Results:&lt;/b&gt; There was a significant difference between all groups (p<0.001) in Wnt and PI3K expression. The real role of ZAM in cervical cancer tissue was seen at the highest ZAM dose (P&lt;sub&gt;3&lt;/sub&gt;). Irregular mucosal folds and stretched interstitial connective tissue in the K+ group can return to regularity and improve at the P&lt;sub&gt;3&lt;/sub&gt; dose. The administration of ZAM showed a significant difference in cervical tissue after benzopyrene injection. &lt;b&gt;Conclusion:&lt;/b&gt; Andaliman (&lt;i&gt;Zanthoxylum acanthopodium&lt;/i&gt;) extract increases PI3K expression through suppression of Wnt expression. It can be developed therapy molecularly to prevent cell growth into cancer.
Hepatitis E Virus: An emerging enigmatic and underestimated pathogen

Hepatitis E virus (HEV) is an RNA virus causing hepatitis E disease. The virus is of one serotype but has diverse genotypes infecting both humans and animals. Based on evidence from seroprevalence studies, about 2 billion people are estimated to have been infected with HEV globally. HEV, therefore, poses a significant public health and economic challenge worldwide. HEV was discovered in the 1980s and was traced back to the 1955 - 1956 outbreak of hepatitis that occurred in India. Subsequently, several HEV epidemics involving thousands of individuals have occurred nearly annually in different countries in Asia and Africa. Initially, the virus was thought to be only enterically transmitted, and endemic in developing countries. Due to the environmental hygiene and sanitation challenges in those parts of the world. However, recent studies have suggested otherwise with the report of autochthonous cases in industrialised countries with no history of travel to the so-called endemic countries. Thus, suggesting that HEV has a global distribution with endemicity in both developing and industrialised nations. Studies have also revealed that HEV has multiple risk factors, and modes of transmission as well as zoonotic potentials. Additionally, recent findings have shown that HEV leads to severe disease, particularly among pregnant women. In contrast to the previous narration of a strictly mild and self-limiting infection. Studies have likewise demonstrated chronic HEV infection among immunocompromised persons. Consequent to these recent discoveries, this pathogen is considered a re - emerging virus, particularly in the developed nations. However, despite the growing public health challenges of this pathogen, the burden is still underestimated. The underestimation is often attributed to poor awareness among clinicians and a lack of routine checks for the disease in the hospitals. Thus, leading to misdiagnosis and underdiagnosis. Hence, this review provides a concise overview of epidemiology, diagnosis, and prevention of hepatitis E.
Ecological security assessment of the Guanzhong Plain urban agglomeration based on an adapted ecological footprint model

The acceleration of urbanization and industrialization has led to new ecological security (ES) risks for urban agglomerations in developing countries. The level of ES with the goal of improving adaptive capacity is becoming the basis for space demand regulation and coordinated development of ecological economy. In relation to the actual socio-economic development of the Guanzhong Plain urban agglomeration (GPUA), three sub-accounts covering domestic water, production water and eco-environment water were added to the adapted ecological footprint model to reflect the underestimated water demand in the GPUA. Based on an analysis of the per capita ecological deficit and the dynamic changes in each account in the GPUA from 2005 to 2017, the ecological pressure index and eco-economic coordination index were used to evaluate the ES level of GPUA, and the footprint depth and footprint size were used to evaluate trends in the state of ES. The results show that (1) the GPUA water resource account is the second largest contribution account to the ecological footprint; (2) the GPUA has been at the 6(th) ES level, "completely unsafe", since 2005; and (3) based on the three-dimensional ecological footprint, the GPUA needs 4.76 times current area to meet its resource consumption level, indicating that ecological insecurity levels will not improve. Therefore, improving the water resources management system, controlling the sources of atmospheric pollution, and strengthening the zoning of functional lands are recommended. Quantitatively analysing the relationships among the ES level, various resources environmental and economic activities provides a scientific basis for improving the resilience level of urban agglomerations in response to ecological changes. (C) 2020 Elsevier Ltd. All rights reserved.
Identification of medicinal compounds as potential inhibitors for mutated isocitrate dehydrogenases against chondrosarcoma

Chondrosarcoma is the third most common cartilaginous bone tumour that is insusceptible to radio- and chemotherapy and it is inclined to metastasis. These resistant qualities are facilitated by mutant variants of isocitrate dehydrogenases (IDH) 1-2 enzyme. These mutant enzymes promote oncogenesis of chondrocytes by changing their epigenetic wardrobe leading to tumour formation. Presently, there are lack of drugs available to be exploited as a remedy for this disease. On the other hand, majority of chemotherapeutic drugs induce cytotoxicity in the cancer cells at the cost of harming surrounding healthy cells, jeopardizing human life. The current study is focused on screening various medicinal compounds against IDH1 and IDH2 combined with insilico gene expression, cancer cells cytotoxicity and ADMET (absorption, distribution, metabolism, excretion and toxicity) studies to elucidate the molecular mechanism against chondrosarcoma and also to uncover pharmacokinetic profile of these compounds. Screening of 5000+ compounds filtered two efficacious compounds (Artocarpetin and 5-Galloylquinic acid) capable of establishing hydrogen bond connections with both IDH variants. Other studies showed that these compounds downregulate ITGAV, CARPIN1, CCL5 and COG5 and TNFRSF10B gene that reduces chondrogenesis and inflammation, Artocarpetin and 5-galloylquinic acid are TP53 expression enhancer and inhibit MM9 expression that promote immunomodulation and apoptosis in these cancers. These compounds are both active against CHSA8926 and CHSA011 cell line of chondrosarcoma. However, the ADME profile of 5-galloylquinic acid is slightly unsatisfactory based on druglikness and bioavailability score criteria as compared to artocarpetin. Both of these compounds are class-5 chemicals and require high doses to elicit adverse response. Our results suggest that artocarpetin and 5-galloylquinic acid are efficacious drug candidates and could be further exploited to validate these findings in vitro.
Thermo-hydraulic performance of nanofluids flow in various internally corrugated tubes

This study examines the impact of corrugation configuration on the thermal, hydraulic, and overall energy performances of nanofluid flows in corrugated tubes. Different fluids (distilled water "DW", GNP-SDBS/DW, Al2O3/DW, and SiO2/DW) and tube geometries (rectangular, triangular, trapezoidal, and curved ribs) are investigated using a carefully validated computational fluids dynamics (CFD) model. Compared to DW flow in a smooth tube, the maximum overall performance improvement (similar to 37 %) was found in the case of GNP-SDBS/DW nanofluid flow in a curvedly ribbed tube at Re of 10,000. For all fluids and tube geometries, the overall performance enhancement was found to decrease at Reynolds numbers higher than 10,000. Curvedly ribbed tubes have better performances at medium and high flow rates, regardless of the fluid type. However, at low flow rates or when the pumping power consumption is not a major concern, trapezoidal ribs can be used to achieve higher heat transfer rates. Overall, using corrugated tubes (maximum performance improvement of similar to 20 %) was found a more energy-efficient technique than using nanofluids (up to similar to 11 %). Combining both techniques achieves enhances the performance by up to similar to 37 %. These findings can be used as a guide for determining the most suitable technique based on an overall techno-economic evaluation.
Seed and seedling diversity delimitation and differentiation of Indian populations of Melia dubia cav

Melia dubia is one of the most important industrial tree species in the South East Asia. In last few decades, the populations of M. dubia has rapidly expanded in the Indian sub-continents, leading to an increase in the genetic diversity of species. However, very less information is available on intra-specific variation in Melia under the Indian subcontinent. Therefore, a present investigation was undertaken, to assess the level of diversity in seed and saplings of the Melia populations (ecotypes) collected from three agro-ecological regions of India. Results revealed that the seed and saplings of all the ecotypes are significantly different for all the traits, except for number of branches per plant, and the maximum variability was recorded in germination percentage, seed weight, internodal length, and sapling height of the species. The high heritability for seed weight (0.99), length (0.99), and width (0.97), and germination percentage (0.99) indicated that selection and genetic gain for these traits would be effective during the commencement of improvement program. Trait association analysis explained that higher seed weight significantly reduced sapling height, collar diameter, number of leaves per plant, internodal length, petiole length, and germination percentage (r = -0.86; p < 0.001) that ultimately reduced the seedling vigor in Melia dubia. Interestingly, the number of branches per plant were not associated with any of the morphological traits. The first principal component explained 50.09% of the entire variation and all the traits contributed greatly to the variation for this principal component, except for number of branches, leaf width and seed length. The clustering approach assorted geographic variation of M. dubia populations into three main sub-clusters i.e. South, North, and North East populations each consisting of five, seven and one populations (including cultivar), respectively. Among different ecotypes, Bahumukhi, Varsha and US Nagar seed sources outperformed all others in seedling vigour (sapling height) and rest of the growth parameters. Overall, findings explained that considerable scope exists for the development of superior planting material of M. dubia through exploration of seeds and selection at the early seedling stage.
Optimization of reduced chemical fertilizer use in tea gardens based on the assessment of related environmental and economic benefits

Chemical fertilizer application is the primary method used to maintain tea yield and quality, but has a negative environmental impact owing to its excessive use. This study sought to assess the environmental and economic benefits of three different chemical fertilizer reduction modes: Single reduction of chemical fertilizer (SRCF), combined application of organic and chemical fertilizer (CAOF), and controlled-release fertilizer substitute (CRFS). Differences in soil nutrient content, NP (NH4+-N, NO3-N and total P) runoff loss, tea yield and quality, and the revenue of tea planting across different fertilizer reduction treatments were then discussed. We also analyzed the coupling effects of these different fertilization modes, fertilization rate and time on soil NP runoff loss, which allowed us to determine the optimum fertilization method based on differences in their respective environmental and economic benefits. Our results revealed differences in soil nutrient content, tea yield and quality, NP runoff loss, and revenue owing to tea planting across the different fertilization treatments. Soil pH after fertilization was significantly lower than before fertilization. CAOF was beneficial and improved soil nutrients as well as tea yield and quality. Of the tested methods, 50% combined application of organic and chemical fertilizer (CAOF2) was the best, as it resulted in the best tea quality and yield. CAOF2 also had the highest revenue. In addition, it was beneficial in reducing NP runoff loss. CRFS was advantageous in its persistent fertilizer efficiency and reduction in NP runoff loss. With CAOF, NP runoff loss was primarily caused by quick-acting chemical fertilizer. With extended time, NP runoff loss caused by fertilization was gradually decreased. Given our analysis of the environmental and economic benefits of different fertilizer reduction methods, CAOF2 emerged in this study as the best fertilizer reduction treatment option. (C) 2019 Elsevier B.V. All rights reserved.
Sustainable supplier selection under must-be criteria through Fuzzy inference system

Growing awareness about the environmental and social issues and pressure from all stakeholders has forced industries to adopt sustainability practices in their supply chains. Suppliers contribute significantly to establishing an effective sustainable supply chain. Hence industries need to evaluate its potential suppliers precisely on sustainability criteria. In this work, a two-phase decision model using Fuzzy Interference System (FIS) along with Fuzzy Kano philosophy for the sustainable environment has been proposed to select sustainable suppliers for a large scale industry. In the first phase, sustainability criteria clustering using fuzzy Kano model has been performed for the identification of 'Must-be' criteria in economic, environmental and social dimensions. Further, sub-criteria with quantified evaluation levels for Must-be criteria have been established. In the second phase, the three distinct Fuzzy Inference System (FIS) has been developed for evaluating the Sustainability Performance Index (SPI) values of each supplier in three sustainability dimensions. In FIS, the architecture of each model is modified in such a way that each FIS engine have to compute the minimum number of rules. Finally, weights are assigned to SPI in each dimension, and suppliers are ranked for final selection. Sensitivity analysis has been performed to demonstrate the robustness of the proposed decision framework. A sustainable supplier selection problem of the iron and steel industry of India has been investigated to show the effectiveness and applicability of the proposed decision framework. (c) 2019 Elsevier Ltd. All rights reserved.
When the fourth water and digital revolution encountered COVID-19

The ongoing COVID-19 pandemic is, undeniably, a substantial shock to our civilization which has revealed the value of public services that relate to public health. Ensuring a safe and reliable water supply and maintaining water sanitation has become ever more critical during the pandemic. For this reason, researchers and practitioners have promptly investigated the impact associated with the spread of SARS-CoV-2 on water treatment processes, focusing specifically on water disinfection. However, the COVID-19 pandemic impacts multiple aspects of the urban water sector besides those related to the engineering processes, including sanitary, economic, and social consequences which can have significant effects in the near future. Furthermore, this outbreak appears at a time when the water sector was already experiencing a fourth revolution, transitioning toward the digitalisation of the sector, which redefines the Water-Human-Data Nexus. In this contribution, a product of collaboration between academics and practitioners from water utilities, we delve into the multiple impacts that the pandemic is currently causing and their possible consequences in the future. We show how the digitalisation of the water sector can provide useful approaches and tools to help address the impact of the pandemic. We expect this discussion to contribute not only to current challenges, but also to the conceptualization of new projects and the broader task of ameliorating dimate change. (C) 2020 Elsevier B.V. All rights reserved.
Assessment of wind-induced nonlinear post-critical performance of bridge decks

A quantitative analysis of the wind-induced post-critical performance of bridge decks is presented in order to highlight the underlying wind-resistant capacity after the critical wind speeds. Two simple indices, i.e., the wind speed extension (after the critical state) with acceptable post-critical vibrations and the relative post-critical capacity (i.e., the ratio between the aforementioned wind speed extension and the critical speed value), are utilized to quantify the post-critical performance of bridge decks. A short review on available limit states of vibration in literatures and design codes is presented in order to define a suitable threshold for acceptable post-critical vibrations. The post-critical performances of three typical cross-sections are quantitatively analyzed with the proposed indices, in which the limit states of vibration are reasonable defined considering either structural normal operation or structural safety. The effects of various mechanical and aerodynamic properties (e.g., mechanical damping ratio, natural frequency, initial angle of attack, and aerodynamic derivatives) on the post-critical behaviors of the selected cross-sections are highlighted. The quantitative analysis of the post-critical performance in the present work may deepen the understanding of the wind-resistant performance of bridges and potentially serve as a building block for a more economic wind-resistant design framework for future long-span bridges.
Efficient degradation of lomefloxacin by Co-Cu-LDH activating peroxymonosulfate process: Optimization, dynamics, degradation pathway and mechanism

In this study, bimetal layered double hydroxides (CoxCuy-LDHs) containing a carbonate interlayer were synthesized using coprecipitation with a variety of Co/Cu mole ratios. Meanwhile, the corresponding layered double oxides (CoxCuy-LDOs) were prepared as controls. In this study, Electrical energy per order was performed to evaluate economic analysis. Correspondingly, we found that CoxCuy-LDHs possessed a significantly better PMS activation capability than the corresponding metal oxide composite (Co3O4/CuO). Compared with other Co(x)Cu(y)LDHs, Co2Cu1 LDH possessed the best PMS activation capability for LOM degradation and the lowest electrical energy per order (EE/O) value during the reaction. Additionally, Co2Cu1 LDH presented an excellent stability and worked over a wide pH range. The hydroxide states of Co(III), Co(II), Cu(I) and Cu(II) were all able to activate PMS, indicating that there were many active sites on the surface of Co2Cu1 LDH. The involvement of radicals in this reaction system was determined via scavenger experiments and electron paramagnetic resonance (EPR). Meanwhile, it's worth noting that a mathematical model was developed to quantify the involvement of SO4 center dot- and center dot OH. Subsequently, we determined PMS activation mechanism and LOM decomposition pathway for the PMS/Co2Cu1 LDH system.
Implementation of large-scale Li-ion battery energy storage systems within the EMEA region

Large-scale Lithium-ion Battery Energy Storage Systems (BESS) are gradually playing a very relevant role within electric networks in Europe, the Middle East and Africa (EMEA). The high energy density of Li-ion based batteries in combination with a remarkable round-trip efficiency and constant decrease in the levelized cost of storage have led to the recent boom of the technology. However, many of the potential applications of large-scale battery systems are not economically viable at this point in time. As a result, several BESS projects are being pushed by the industry towards specific niches which are based on revenue streams that can be rather complex than straightforward. The aim of this paper is to provide an overview of how large-scale Li-ion BESS are currently being implemented in the EMEA region, giving an answer to the following questions: what are the main use-cases of large-scale Li-ion batteries that are being implemented? What are the key factors that are enabling the deployment of BESS projects in the present markets? How can current tendencies be extrapolated to the future outlook of Li-ion BESS implementations? The large-scale energy storage market is evolving at a very fast pace, hence this review paper intends to contribute to a better understanding of the current status of Li-ion battery systems focusing on the economic feasibility that is driving the realization of Li-ion BESS projects in the EMEA region.
On the snow leopard Trails: Occupancy pattern and implications for management in the Pamir

The snow leopard (Panthera uncia) inhabits one of the most challenging environments on Earth, referred to as the 'third pole'. Only a fraction of its vast range has been explored thus far, owing to myriad of barriers inflicted by the remote terrain and socio-ecological realities of the landscapes. Understanding distribution patterns of species is essential to devise practical management measures. This study aimed to understand the distribution pattern and factors influencing occupancy of snow leopard in the Pamir Mountain range through sign-based occupancy modelling. Our study confirmed that the Pamir range is a snow leopard stronghold, with occupancy estimated at 0.57 ± 0.02. The topographic features positively influenced the detection probability (p = 0.37 ± 0.005) of snow leopards. Occupancy was influenced by mean annual precipitation (β = -6.12 ± 1.8), density of roads (β = -1.61 ± 0.6) and water sources (β = 0.74 ± 0.4). Our findings underpin that sign-based distribution surveys provide vigorous scientific knowledge about elusive species and merit replication being used for other species. We propose to redefine the protected area boundaries based on ecological knowledge and encourage transboundary cooperation to safeguard snow leopards at a landscape scale.