ahmedabdelwahed/Medical_papers_title_and_abstract_NLP_dataset huggingface dataset:
Are eco-innovation and export diversification mutually exclusive to control carbon emissions in G-7 countries?

Most of the member countries of COP21 have been struggling to devise relevant policies in order to control carbon dioxide (CO2) emissions since the Paris agreement in 2015. In our view, without analyzing the role of two extremely important variables i.e., ecological innovation and export diversification, in the whole chain of carbon emissions, expecting significant results from such policies would be far fetched. This study, therefore, is aimed to explore the effect of export diversification (ED) and ecological innovation (EI) on carbon emissions for G-7 countries from 1990 to 2017, along with renewable energy consumption (REC) as an important control variable. The results show that export diversification (ED) increases carbon emissions; however, ecological innovation (EI) helps reduce carbon emissions, and similarly, renewable energy consumption (REC) also controls carbon emissions. More important, however, is the realization that the negative impact of export diversification on the CO2 emissions gets weakened as the degree of environmental innovation increases. Based on our findings, the promotion of renewable energy, along with the adoption of environmentally friendly technology, is strongly recommended for G-7 countries. Our results also highlight that Government policies regarding export diversification (ED), ecological innovation (EI), and renewable energy consumption (REC) approximately take more than a year to be able to deliver the results effectively.
Dill Shows Potential for Herb-Drug Interactions via Up-Regulation of CYP1A2, CYP2C19, SULT1A1, NAT2 and ABCB1  in Caco-2 Cells

&lt;b&gt;Background and Objective:&lt;/b&gt; Dill&lt;i&gt; &lt;/i&gt;(&lt;i&gt;Anethum graveolens&lt;/i&gt; L.) has the potential to develop as a new alternative medicine due to its pharmacological activities. However, studies into its safety regarding herb-drug interactions have been neglected. This study investigated the risk of dill-induced herb-drug interactions (HDI) by examining its effect on the expression of phase I and II drug-metabolizing enzyme and transporter genes in Caco-2 cells. &lt;b&gt;Materials and Methods:&lt;/b&gt; Caco-2 cells (5×10&lt;sup&gt;5&lt;/sup&gt; cells/well) were treated with 10 μM ketoconazole, 20 μM rifampicin or dill extract (60-240 μg mL&lt;sup&gt;1&lt;/sup&gt;) for 72 hrs. Cell viability was assessed using the resazurin assay and reactive oxygen species (ROS) content was determined with 2 ,7 -dichlorofluorescein diacetate. Aspartate (AST) and alanine aminotransferase (ALT) levels were measured using L-aspartate and L-alanine with α-ketoglutarate as substrate. Expression of phase I (&lt;i&gt;CYP1A2&lt;/i&gt;, &lt;i&gt;CYP2C19&lt;/i&gt;, &lt;i&gt;CYP2D6&lt;/i&gt;, &lt;i&gt;CYP2E1 &lt;/i&gt;and &lt;i&gt;CYP3A4&lt;/i&gt;) and II (&lt;i&gt;UGT1A6&lt;/i&gt;,&lt;i&gt; SULT1A1&lt;/i&gt;,&lt;i&gt; NAT1&lt;/i&gt;,&lt;i&gt; NAT2 &lt;/i&gt;and&lt;i&gt; GSTA1/2&lt;/i&gt;) metabolizing genes and transporters (&lt;i&gt;ABCB1&lt;/i&gt;,&lt;i&gt; ABCC2&lt;/i&gt;,&lt;i&gt; ABCG2 &lt;/i&gt;and &lt;i&gt;SLCO1B1&lt;/i&gt;) were determined by RT/qPCR. &lt;b&gt;Results:&lt;/b&gt; All tested concentrations of dill did not affect cell viability or AST and ALT levels. The highest concentration of dill extract (240 μg mL&lt;sup&gt;1&lt;/sup&gt;) significantly lowered the ROS level. Expression of &lt;i&gt;CYP1A2&lt;/i&gt;, &lt;i&gt;CYP2C19&lt;/i&gt;, &lt;i&gt;SULT1A1&lt;/i&gt;, &lt;i&gt;NAT2 &lt;/i&gt;and &lt;i&gt;ABCB1 &lt;/i&gt;mRNA was significantly up-regulated by dill extract. &lt;b&gt;Conclusion:&lt;/b&gt; Dill extract did not directly damage Caco-2 cells but prolonged use of dill may increase the risk of HDI via the up-regulation of the drug-metabolizing genes &lt;i&gt;CYP1A2&lt;/i&gt;, &lt;i&gt;CYP2C19&lt;/i&gt;, &lt;i&gt;SULT1A1&lt;/i&gt;, &lt;i&gt;NAT2 &lt;/i&gt;and the transporter &lt;i&gt;ABCB1&lt;/i&gt;.
Menthol in Combination with Iontophoresis Promotes Natamycin Penetration through the Cornea: In Vitro and In Vivo Studies

We studied whether menthol can promote penetration of natamycin, a representative antifungal macrolide agent, through the cornea. Natamycin penetration was examined using an in vitro iontophoresis system that simulates clinical scenario; menthol (0.1-0.3%, w/v) was added to the donor reservoir of a standard Franz diffusion chambers. In vivo effects of menthol on natamycin penetration were examined in a set of bioassays using rabbits inoculated with Aspergillus fumigatus in the right eye. Potential irritation to the rabbit eye was examined using a standard test. Menthol significantly (p<0.05) potentiated the effects of iontophoresis on natamycin penetration. The optimal combination seemed to be 0.2% menthol in combination with 3 mA/cm2 iontophoresis.
Corporate Social Performance and Firm Performance: Comparative Study among Developed and Emerging Market Firms

This study examines the impact of firms' environmental, social and governance (ESG) initiatives on financial performance. It also compares the valuation effects of corporate social performance initiatives in developed and emerging market firms. The study was based on ESG ranking scores in the Thomson Reuters database, and the sample comprised 1317 emerging market firms and 3569 developed market firms. In comparison with developed market firms, emerging market firms had higher ESG combined scores, ESG Controversy scores, category scores of resources use, workforce, human rights and corporate social responsibility strategy scores. This study finds that stakeholder initiatives positively impact valuation effects, based on all sample results. Firm-generated controversies may decrease valuation effects in the stock market. Results indicated that ESG initiatives have a significant positive to the firm performance. The presence of independent board members and ownership by investors is a positive determinant for value creation. The adoption of best practice corporate governance principles is an important determinant of the valuation of firms. Firms' propensity to use defence mechanisms decreases valuation effects. Developed market firms received positive valuation effects due to ESG initiatives.
Impact of Geographic Distribution of COVID-19 Cases on Hotels' Performances: Case of Polish Cities

The main goal of the article is to describe the short-term impacts of reported new cases and deaths of the COVID-19 disease on hotels' performances in the nine major Polish urban hotel markets: Krakow, Warszawa, Pozna, Wrocaw, Gdask, Lublin, od, Katowice, and Sopot. Time range of the analysis covers the period from January 5, 2020 (the beginning of the very first week when the COVID-19 cases were evidenced) to March 14, 2020 (the initial phase of lockdown was introduced by the Polish government). Various geographical contexts of the COVID-19 impacts are considered: national, European, and global. Generalized method of moments was applied to investigate the influence of reported COVID-19 cases (deaths) on both occupancy and revenue per available room. The results show that the most significant, negative impact of the pandemic on hotel performances is confirmed at the European level of the COVID-19 outbreak. Moreover, the negative influence of national cases of COVID-19 is more significant in less internationalized (or less-populated) urban destinations. Thus, the hotel industry (especially in the most internationalized, biggest Polish cities) might be recovered only when issues of the COVID-19 epidemic will be solved at the European level.
Life cycle costing for plasma gasification of municipal solid waste: A socio-economic approach

Fossil fuels contribute to climate changes, negatively affecting the environment. Waste has been seen as a possible resource for energy production, constituting a cleaner alternative to replace non-renewable fuels through waste-to-energy (WtE) techniques. Plasma gasification is a procedure that decomposes the molecules at high temperatures, affording a synthetic gas (syngas) that can further produce electricity, fuels and chemicals. Within the most used WtE technologies, plasma gasification is recent and therefore not yet widely applied. Thus, a viability study to support the thorough understanding and implementation of this treatment is required. This paper assesses the socio-economic aspects of plasma gasification promoting a more sustained waste management system, also taking advantage of the commodity assets granted by the technique. To the best of the authors' knowledge, this is the first time that an importance-fulfilment matrix is specifically developed to appraise the socio-economic viability of plasma gasification, combining environmental, technical, economic and social aspects. Although depicting high capital costs, plasma gasification enabled high revenues, rebating the operational costs. The sensitivity analysis exhibited a descending impact in the profitability of the plant for varying electricity sales price, landfill fee, discount rate, vitrified slag sales price and initial investment.
Assessment and prediction of the water ecological carrying capacity in Changzhou city, China

With rapid economic development and population growth, pressure on the urban ecological environment is becoming intense, and the ecological environment carrying capacity is becoming an important issue. In this study, an index system combining the system dynamics (SD) and analytic hierarchy process (AHP) methods was constructed to assess the water ecological carrying capacity (WECC) of Changzhou city. In particular, the construction of the aquatic habitat and aquatic organism indexes were constructed and showed that water ecology health should be monitored along with the economy and population, which were focused in the past. Scientific research has neglected the internal spatial heterogeneity in administrative regions. Therefore, the SD and AHP models were applied to simulate the WECC of administrative regions and control units from 2010 to 2016. The simulation results show that the WECC of Liyang and Jintan counties reached a safe carrying capacity state, while the urban districts were in a critically overloaded state. In addition, the MIKE11 model was adopted to simulate the WECC under different inflow and the river connectivity index scenarios, and the optimal parameters for improving the WECC were obtained when the inflow recharge was 10m(3)/s and the river connectivity index exceeded 60%. The prediction results from the optimized WECC showed that the WECC of all administrative areas and control units in Changzhou city reached the safe carrying capacity state. The results provide insights for improving the WECC of Changzhou city. (C) 2020 Elsevier Ltd. All rights reserved.
Avoiding immediate whole-body trauma CT: a prospective observational study in stable trauma patients

High energy blunt trauma patients with normal vital signs are usually investigated with a Contrast Enhanced Computed Tomography (CECT) for torso injuries. CECT involves high levels of radiations, often showing no injuries in patients over-triaged to the trauma center. The aim of our study was to suggest an alternative diagnostic protocol based on Emergency Room (ER) tests (physical exam, blood tests, extended FAST, Chest and Pelvis X-ray) to avoid CECT in selected patients. A prospective cohort study was conducted from September 2018 to September 2019. Five hundred patients fulfilled the inclusion criteria. Patients received torso-CECT scan only if they had at least one positive ER test. The validity of the single component of the protocol and the global validity of the ER tests to detect torso injuries was assessed through sensitivity, specificity, positive (PPV) and negative (NPV) predictive value, positive (+ LR) and negative (- LR) likelihood ratio. Multivariate analysis was performed to identify independent predictors of torso injuries. One hundred and seventy patients received a torso-CECT scan because of positive ER tests. ER tests showed a global sensitivity for torso injuries of 86.96% (95% CI 80.17-92.08) specificity of 83.98%(95% CI 79.79-87.60), PPV of 67.42% (95% CI 61.83-72.54), NPV of 94.41% (95% CI 91.63-96.30) + LR of 5.43 (95% CI 4.25-6.93), - LR of 0.16 (95% CI 0.10-0.24). ER tests in an experienced center seem to be able to identify more severe blunt trauma patients needing CECT. Further studies are advisable to confirm these results.
Systematic literature review of insulin dose adjustments when initiating hemodialysis or peritoneal dialysis

Chronically uncontrolled hyperglycemia is the leading cause of end stage kidney disease (ESKD) necessitating dialysis. During times of transition to hemodialysis (HD) or peritoneal dialysis (PD), considerations must be given to insulin dosing adjustments for persons with diabetes (PWD) in efforts to maintain glycemic control. However, the literature is sparse with few clear and direct practical clinical recommendations for therapeutic insulin dosing adjustments in PWD and ESKD. The objective of this systematic review was to identify and report the evidence and gaps in the literature for adjustments in therapeutic insulin recommendations when initiating HD or PD in patients with ESKD and diabetes mellitus. A literature search using PubMed, CENTRAL, MEDLINE, CINAHL, Google Scholar, and ClinicalTrials.gov revealed 242 results. After removing duplicates and articles not reaching pre-specified criteria, 29 relevant articles remained for further analysis. Following the exclusion of 18 articles after full-text review due to lack of relevance or inappropriate publication type, 11 articles remained and were included in the review. The most common recommendation regarding HD was to reduce the basal insulin dose up to 25% on HD days to prevent hypoglycemia, although a lack of consensus exists on the percent reduction. Little information was found relating to insulin management with continuous ambulatory PD or automated PD. During PD, insulin may be administered subcutaneously, IP, or with the dialysis fluid. Administration of insulin with dialysate may necessitate a dose increase of up to 30% due to a loss to tubing and dilution. Furthermore, the use of dextrose-based dialysate may require additional insulin to mitigate systemic impact of dextrose absorption on BG. Overall, a gap exists in the primary literature regarding recommendations for prophylactically adjusting insulin therapy when initiating HD or PD, or when switching between the two. More research is needed to clarify ideal alterations in insulin dosing, administration techniques, and product selections for PWD and ESKD undergoing dialysis.
Pathophysiology of Hemorrhage as It Relates to the Warfighter

Saving lives of wounded military warfighters often depends on the ability to resolve or mitigate the pathophysiology of hemorrhage, specifically diminished oxygen delivery to vital organs that leads to multiorgan failure and death. However, caring for hemorrhaging patients on the battlefield presents unique challenges that extend beyond applying a tourniquet and giving a blood transfusion, especially when battlefield care must be provided for a prolonged period. This review describes these challenges and potential strategies for treating hemorrhage on the battlefield in a prolonged casualty care situation.
The E3 Ubiquitin Ligase TRAF6 Interacts with the Cellular Prion Protein and Modulates Its Solubility and Recruitment to Cytoplasmic p62/SQSTM1-Positive Aggresome-Like Structures

The cellular prion protein (PrPC) is a ubiquitous glycoprotein highly expressed in the brain where it is involved in neurite outgrowth, copper homeostasis, NMDA receptor regulation, cell adhesion, and cell signaling. Conformational conversion of PrPC into its insoluble and aggregation-prone scrapie form (PrPSc) is the trigger for several rare devastating neurodegenerative disorders, collectively referred to as prion diseases. Recent work indicates that the ubiquitin-proteasome system is involved in quality control of PrPC. To better dissect the role of ubiquitination in PrPC physiology, we focused on the E3 RING ubiquitin ligase tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6). Here, we report that PrPC interacts with TRAF6 both in vitro, in cells, and in vivo, in the mouse brain. Transient overexpression of TRAF6 indirectly modulates PrPC ubiquitination and triggers redistribution of PrPC into the insoluble fraction. Importantly, in the presence of wild-type TRAF6, but not a mutant lacking E3 ligase activity, PrPC accumulates into cytoplasmic aggresome-like inclusions containing TRAF6 and p62/SQSTM1. Our results suggest that TRAF6 ligase activity could exert a role in the regulation of PrPC redistribution in cells under physiological conditions. This novel interaction may uncover possible mechanisms of cell clearance/reorganization in prion diseases.
Carbon Dots: An Excellent Fluorescent Probe for Contaminant Sensing and Remediation

Pollution-induced degradation of the environment is a serious problem for both developing and developed countries. Existing remediation methods are restricted, necessitating the development of novel remediation technologies. Nanomaterials with unique characteristics have recently been developed for remediation. Quantum dots (QDs) are semiconductor nanoparticles (1-10 nm) with optical and electrical characteristics that differ from bigger particles owing to quantum mechanics, making them intriguing for sensing and remediation applications. Carbon dots (CDs) offer better characteristics than typical QDs, such as, CdSe QDs in terms of contaminant sensing and remediation. Non-toxicity, chemical inertness, photo-induced electron transfer, good biocompatibility, and adjustable photoluminescence behavior are all characteristics of CDs. CDs are frequently made from sustainable raw materials as they are cost-effective, environmentally compactable, and excellent in reducing waste generation. The goal of this review article is to briefly describe CDs fabrication methods, to deeply investigate the criteria and properties of CDs that make them suitable for sensing and remediation of contaminants, and also to highlight recent advances in their use in sensing and remediation of contaminants.
Psychological assessment of atopic dermatitis in Asia: a systematic review

Atopic dermatitis (AD) is a frequently occurring skin disorder in Asia that substantially impacts the social, financial, and psychological lives of individuals. However, there is uncertainty regarding the psychological instruments for this domain. Hence, this review systematically assessed the existing measurement instruments used, developed, and/or validated for the measurement of psychological outcomes in Asian adult patients with AD as well as the scope of those assessment tools (e.g. validity and reliability). Electronic searches were performed using six databases (inception to February 2020) to identify studies. Thematic analysis of 44 included studies revealed that the commonly employed tools to assess the quality of life were the Dermatology Life Quality Index followed by the Skindex-16 questionnaire, the European Quality of Life-5 Dimensions, and the Quality of Life Hand Eczema Questionnaire. Similarly, the Patient Health Questionnaire, Self-rating depression scale (SDS), and Hospital Anxiety and Depression Scale were frequently employed to assess depressive symptoms. Additionally, symptoms of anxiety were frequently assessed through Interaction Anxiousness Scale and the Spielberger State-Trait Anxiety Inventory. Although a variety of psychological assessment measures have been used in research, data on their reliability and validity is limited. Also, information on the cultural applicability of these instruments is scantier. More research is needed to ascertain the suitability of tools for use in clinical practice.
The impact of regional industrial structure differences on carbon emission differences in China: An evolutionary perspective

All industries produce different carbon emissions during their production process. Previous studies use multivariate regression or panel models to explore the impact of the industrial structure on regional carbon emissions differences based on time series data or panel data from the perspective of one-dimensional continuous variables. However, there are also regional differences in the factors affecting regional carbon emission differences, such as the economic development level, the industrial structure, and urbanization. The regional carbon emission difference matrix and the influencing factor difference matrix are relational variables, and it is difficult for traditional multiple regression analysis to study the relationship between relational variables. Thus, this paper proposes the perspective of two-dimensional difference relations for studying the influencing factors of regional carbon emission differences based on Quadratic Assignment Procedure model. Energy consumption and the value added by industrial processes in various industries from 30 regions in China are taken as the sample. The results of this study are as follows: carbon emissions are increasing and the differences in carbon emissions between regions are also increasing. There are obvious regional differences in the industrial structure, economic growth, population and urbanization in China. The influence and magnitude of the impact of regional industrial structure differences on regional carbon emission differences vary from year to year. Interregional differences in industry, construction and transportation and warehousing industries had a significantly positive impact on interregional differences in carbon emissions from 2007 to 2016. By analyzing the impact of the influence mechanism of regional industrial structure differences on carbon emissions, the findings of this study can identify some suggestions for regionally balanced emission reduction policies. (C) 2020 Elsevier Ltd. All rights reserved.
The first case report of Strømme syndrome in a Chinese patient: Expanding the phenotype and literature review

Strømme syndrome (MIM #243605) is a rare autosomal recessive ciliopathy resulting from compound heterozygous or homozygous pathogenic alterations in the CENPF gene (# 600236). Although there are a number of case reports featuring individuals with clinically compatible Strømme syndrome, only 13 affected individuals had molecular confirmation worldwide. Herein, we report a 24 years old Chinese gentleman with molecularly confirmed Strømme syndrome with compound heterozygous pathogenic nonsense variants in NM_016343.3(CENPF):c.436C > T, p.(Gln146*) and c.9280C > T, p.(Arg3094*). He presented with microcephaly, unilateral microphthalmia, single central upper incisor and bilateral preaxial polydactyly. To our knowledge, this is the first reported Chinese individual with molecularly confirmed Strømme syndrome.