ahmedabdelwahed/Medical_papers_title_and_abstract_NLP_dataset huggingface dataset:
Decoupling and decomposition analysis of industrial sulfur dioxide emissions from the industrial economy in 30 Chinese provinces

As one of the largest emitters of sulfur dioxide (SO2), China has faced increasing pressure to achieve sustainable development. This study investigates the decoupling relationship between industrial SO2 emissions and the industrial economy in China during 1996-2015. According to the decoupling results, the study period is divided into four stages: 1996-2001, 2001-2006, 2006-2010, and 2010-2015. These four stages are closely aligned with the major adjustments of the national socio-economic policies. Then, the logarithmic mean Divisia index (LMDI) decomposition method is used to analyze the driving factors of industrial SO2 emissions. The results demonstrate that the SO2 generation intensity and SO2 abatement are the major contributors to reducing industrial SO2 emissions, while the economic activity effect is the primary inhibitory factor. Moreover, the provincial results show that most provinces with weak decoupling state since 2006 are located in less developed provinces with energy-intensive industries. Besides, the economic structure and SO2 generation intensity show negative contributions to reducing industrial SO2 emissions in some of these regions. Based on the results, the attention should be focused on cleaner production to reduce industrial SO2 emissions further, and environmental policies should be tailored to local conditions.
Impact of ex vivo lung perfusion on brain-dead donor lung utilization: The French experience

Ex vivo lung perfusion (EVLP) is a valuable method for expanding the lung donor pool. Its indications currently differ across centers. This national retrospective cohort study aimed to describe the profile of donors with lungs transplanted after EVLP and determine the effectiveness of EVLP on lung utilization. We included brain-dead donors with at least one lung offered between 2012 and 2019 in France. Lungs transplanted without or after EVLP were compared with those that were rejected. Donor group phenotypes were determined with multiple correspondence analysis (MCA). The association between donor factors and lung transplantation was assessed with a multivariable multinomial logistic regression. MCA revealed that donors whose lungs were transplanted after EVLP had profiles similar to the donors whose lungs were declined and quite different from those of donors with lungs transplanted without EVLP. Donor predictors of graft nonuse included age ≥50 years, smoking history, PaO2 /FiO2 ratio ≤300 mmHg, abnormal chest imaging, and purulent secretions. EVLP increased utilization of lungs from donors with a smoking history, PaO2 /FiO2 ratio ≤300 mmHg, and abnormal chest imaging.
Common but differentiated leadership: strategies and challenges for carbon neutrality by 2050 across industrialized economies

Given their historic emissions and economic capability, we analyze a leadership role for representative industrialized regions (EU, US, Japan, and Australia) in the global climate mitigation effort. Using the global integrated assessment model REMIND, we systematically compare region-specific mitigation strategies and challenges of reaching domestic net-zero carbon emissions in 2050. Embarking from different emission profiles and trends, we find that all of the regions have technological options and mitigation strategies to reach carbon neutrality by 2050. Regional characteristics are mostly related to different land availability, population density and population trends: While Japan is resource limited with respect to onshore wind and solar power and has constrained options for carbon dioxide removal (CDR), their declining population significantly decreases future energy demand. In contrast, Australia and the US benefit from abundant renewable resources, but face challenges to curb industry and transport emissions given increasing populations and high per-capita energy use. In the EU, lack of social acceptance or EU-wide cooperation might endanger the ongoing transition to a renewable-based power system. CDR technologies are necessary for all regions, as residual emissions cannot be fully avoided by 2050. For Australia and the US, in particular, CDR could reduce the required transition pace, depth and costs. At the same time, this creates the risk of a carbon lock-in, if decarbonization ambition is scaled down in anticipation of CDR technologies that fail to deliver. Our results suggest that industrialized economies can benefit from cooperation based on common themes and complementary strengths. This may include trade of electricity-based fuels and materials as well as the exchange of regional experience on technology scale-up and policy implementation.
The impact of R&D expenditures on CO2 emissions: Evidence from sixteen OECD countries

This study analyzes the impact of research and development (R&D) expenditures on CO2 emissions in 16 Organisation for Economic Co-operation and Development (OECD) countries for the period between 1981 and 2014. The estimates of long-run regression models show that the expected average effect of R&D expenditures on CO2 emissions is negative. Growth of R&D investments by 1% reduces CO2 emissions by 0.09%-0.15% on average. However, estimated country-specific regressions indicate that the long-run effect of R&D expenditures on CO2 emissions can be both positive and negative, and they vary from -0.79% in Denmark to 0.52% in Belgium. In other words, in most cases, viewed from a long-term perspective, higher R&D expenditures reduce CO2 emissions, but this does not apply to about 40% of countries. In addition, the estimation of the short-run time-varying coefficient panel data models indicated that R&D impact can be positive, negative, but also neutral (insignificant) for many years. Such findings suggest a conclusion that the effect of R&D investments on CO2 emissions cannot be characterized as negative in advance, as pointed out by numerous analysis, but must be empirically estimated. The practical significance of this study is reflected in the fact that it directs decision-makers to concentrate their efforts on promoting R&D programs, such as those in the US and Germany, which are directly focused on reducing CO2 emissions and increasing the use thereof. (c) 2019 Elsevier Ltd. All rights reserved.
H-2-based synthetic fuels: A techno-economic comparison of alcohol, ether and hydrocarbon production

Electricity-based fuels are one promising option to achieve the transition of the energy system, and especially the transport sector, in order to minimize the role of fossil energy carriers. One major problem is the lacking compatibility between different techno-economic assessments, such that recommendations regarding the most promising Power-to-Fuel technology are difficult to make. This work provides a technically sound comparison of various Power-to-Fuel options regarding technological maturity and efficiency, as well as cost. The investigated options include methanol, ethanol, butanol, octanol, DME, OME3-5 and hydrocarbons. To guarantee the comparability, all necessary chemical plants were designed in Aspen Plus (R) to determine material and energy consumption, as well as investment costs within the same boundary conditions and assumptions in all simulations and calculations. Individual technical aspects of the various synthesis routes, as well as their advantages and disadvantages, are highlighted. With an assumed electrolysis efficiency of 70% and considering the energy demand for the CO2 supply and the energy and operating material demand of the chemical plants, depending on the selected electrofuel, 30-60% of the primary energy in renewable electricity can be stored in the lower heating value of the electrofuel. In the presented results, the costs of H-2 supply are responsible for 58-83% of the total manufacturing costs and thus have the greatest potential to reduce the latter. For the base case (4.6 (sic)/kg(H2)), various electrofuels will have costs of manufacturing of between 1.85 and 3.96 (sic)/l(DE), with DME being the cheapest. (C) 2019 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.
The importance of renewable energy consumption and FDI inflows in reducing environmental degradation: Bootstrap ARDL bound test in selected 9 countries

This study examines the relationship between renewable energy consumption, non-renewable energy consumption, foreign direct investment, economic growth and carbon emissions for the nine countries (i.e., Denmark, Finland, France, India, Italy, Morocco, Norway, Portugal, Sweden) identified in the Climate Change Performance Index (CCPI) 2018 report. This study mainly aims to demonstrate the role of renewable energy consumption and foreign direct investment on CO2 emissions in countries with high scores in the CCPI using the newly developed bootstrap autoregressive distributed lag (ARDL) approach. For this purpose, the unit root properties of the variables are determined by sharp and smooth structural break unit root test (SOR, Shahbaz et. al., 2018). We then conduct a bootstrap ARDL test developed by McNown et al. (2018) to investigate the existence of cointegration. We also use Granger causality based on the bootstrap ARDL approach to identify causal relationships between variables. Empirical analysis results show only a few cointegration relationships between variables exist. However, we have identified significant long-term relationships between foreign direct investment, renewable energy consumption and economic growth in some countries, and our study includes important policy implications, particularly for relationship among CO2 emissions and foreign direct investment inflows. (C) 2020 Elsevier Ltd. All rights reserved.
Emergence of size-structured dominance hierarchies through size-dependent feedback

Size-based dominance hierarchies influence fitness, group size and population dynamics and link dominance structure to evolutionary and ecological outcomes. While larger individuals often gain dominance, social status may influence growth and size in return, resulting in feedbacks among status, growth and size. Here, we present two models evaluating how these feedbacks influence the emergence of size structure in a dominance hierarchy. In the first, size influences competition for food and investment in suppressing growth of groupmates. Stable size differences emerged when suppression was greatest for similarly sized individuals and size had little effect on competition for food. The model predicted size divergence when size strongly affected competition for food. In the second model, we used a dynamic game to solve for optimal investment in growth suppression as a function of size structure. Investment in growth suppression was favoured only when dominants and subordinates were similar in size, generating size ratios different than those expected by chance. Variation in the feedbacks among growth, size and status can explain variation in emergent size structure of dominance hierarchies and its consequences for conflict within groups. This article is part of the theme issue 'The centennial of the pecking order: current state and future prospects for the study of dominance hierarchies'.
After-effects of acute footshock stress on sleep states and rhythmic masticatory muscle activity during sleep in guinea pigs

This study investigated the effects of acute footshock stress (FS) on the occurrence of rhythmic masticatory muscle activity (RMMA) during sleep in guinea pigs. Animals were prepared for chronic recordings from electroencephalogram, electrooculogram and electromyograms of neck and masseter muscles. The signals were recorded for six hours on the two successive days: the first day with stress-free condition (non-FS condition) and the second day with acute FS (FS condition). Sleep/wake states and RMMA were scored visually. Sleep variables and the frequency of RMMA occurring during non-rapid eye movement (NREM) sleep were compared during 6-h periods between the two conditions. Compared to non-FS condition, the amount of total sleep and NREM sleep significantly reduced during 2 h following the acute FS in the FS condition. Similarly, the frequency of RMMA significantly increased during 2 h following the acute FS for the FS condition compared to non-FS condition. During 2-6 h after FS in the FS condition, sleep variables and the frequency of RMMA did not differ from those without FS in the non-FS condition. These results suggest that acute experimental stress can induce transient changes in sleep-wake states and the occurrence of RMMA in experimental animals.
CircABCC1 promotes the development of glioma by sponging miR-591 and modulating high-mobility group A2

CircABCC1 plays an oncogenic role in diverse malignancies. In this study, we investigated its involvement in glioma. The expression of circABCC1 and miR-591 was detected in glioma tissues and cell lines. Gain- and loss-of-function assays were performed to determine the biological effects of circABCC1, miR-591, and high-mobility group A2 (HMGA2) in glioma cells. The circABCC1-mediated competitive endogenous RNA (ceRNA) regulatory mechanism was explored by bioinformatics and the luciferase reporter assay combined with the biotinylated RNA pulldown assay. The effect of circABCC1 on the tumorigenicity of glioma in vivo was detected by constructing xenografts in nude mice. CircABCC1 was highly expressed, and miR-591 was downregulated in glioma tissues and cells. Suppression of circABCC1 repressed the malignant behaviors of glioma cells and tumor growth. Through the ceRNA mechanism, circABCC1 interacts with miR-591 to regulate the expression of HMGA2. CircABCC1 functions as an oncogene to promote the progression of glioma via the regulation of miR-591/HMGA2 signaling. In summary, as revealed by our study, circABCC1 promotes the expression of HMGA2 via sponging of miR-591, thus affecting glioma progression as an important onco-circRNA.
A tale of three paradigms: Realising the revolutionary potential of ecological economics

Ecological economics has ontological foundations that inform it as a paradigm both biophysically and socially. It stands in strong opposition to mainstream thought on the operations of the economy and society. The core arguments deconstruct and oppose both growth and price-making market paradigms. However, in contradiction of these theoretical foundations, ecological economists can be found who call upon neoclassical economic theory as insightful, price-making and capitalist markets as socially justified means of allocation and economic growth as achieving progress and development. The more radical steady-state and post-growth/degrowth movements are shown to include confused and conflicted stances in relation to the mainstream hegemonic paradigms. Ecological economics personally challenges those trained in mainstream theory to move beyond their orthodox education and leave behind the flawed theories and concepts that contribute to supporting systems that create social, ecological and economic crises. This paper makes explicit the paradigmatic struggle of the past thirty years and the need to wipe away mainstream apologetics, pragmatic conformity and ill-conceived postmodern pluralism. It details the core paradigmatic conflict and specifies the alternative social ecological economic paradigm along with a new research agenda.
Biodiversity and vector-borne diseases: Host dilution and vector amplification occur simultaneously for Amazonian leishmaniases

Changes in biodiversity may impact infectious disease transmission through multiple mechanisms. We explored the impact of biodiversity changes on the transmission of Amazonian leishmaniases, a group of wild zoonoses transmitted by phlebotomine sand flies (Psychodidae), which represent an important health burden in a region where biodiversity is both rich and threatened. Using molecular analyses of sand fly pools and blood-fed dipterans, we characterized the disease system in forest sites in French Guiana undergoing different levels of human-induced disturbance. We show that the prevalence of Leishmania parasites in sand flies correlates positively with the relative abundance of mammal species known as Leishmania reservoirs. In addition, Leishmania reservoirs tend to dominate in less diverse mammal communities, in accordance with the dilution effect hypothesis. This results in a negative relationship between Leishmania prevalence and mammal diversity. On the other hand, higher mammal diversity is associated with higher sand fly density, possibly because more diverse mammal communities harbor higher biomass and more abundant feeding resources for sand flies, although more research is needed to identify the factors that shape sand fly communities. As a consequence of these antagonistic effects, decreased mammal diversity comes with an increase of parasite prevalence in sand flies, but has no detectable impact on the density of infected sand flies. These results represent additional evidence that biodiversity changes may simultaneously dilute and amplify vector-borne disease transmission through different mechanisms that need to be better understood before drawing generalities on the biodiversity-disease relationship.
A systematic review on active sites and functions of PIM-1 protein

The Proviral Integration of Molony murine leukemia virus (PIM)-1 protein contributes to the solid cancers and hematologic malignancies, cell growth, proliferation, differentiation, migration, and other life activities. Many studies have related these functions to its molecular structure, subcellular localization and expression level. However, recognition of specific active sites and their effects on the activity of this constitutively active kinase is still a challenge. Based on the close relationship between its molecular structure and functional activity, this review covers the specific residues involved in the binding of ATP and different substrates in its catalytic domain. This review then elaborates on the relevant changes in protein conformation and cell functions after PIM-1 binds to different substrates. Therefore, this intensive study can improve the understanding of PIM-1-regulated signaling pathways by facilitating the discovery of its potential phosphorylation substrates.
Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease May be Favoured by the Effects of Proinflammatory Cytokines on the Enteroglial Network

Clostridioides difficile infection is widespread throughout countries and represents an important cause of nosocomial diarrhoea, with relatively high morbidity. This infection often occurs in patients with inflammatory bowel diseases and may complicate their clinical picture. Here, we propose, on the basis of evidence from basic science studies, that in patients affected by inflammatory bowel diseases, this infection might be facilitated by a derangement of the enteric glial cell (EGC) network caused by the effects of proinflammatory cytokines, such as tumour necrosis factor alpha and interferon gamma, which enhance the cytotoxic effects of C. difficile toxin B on EGCs. This hypothesis, if confirmed, could open the door to alternative treatment approaches to fight C. difficile infection.
Optimization and dynamic techno-economic analysis of a novel PVT-based smart building energy system

There is a variety of solar-based energy system designs for buildings. Although these systems are economically profitable, reducing the energy cost of the buildings over time, their penetration has not been that impressive yet due to their high initial cost. In this study, an energy system comprising a few PVT panels (without any batteries) and a heat storage tank is proposed and investigated for smart buildings with two-way interactions with both heat and electricity grids. Removing the battery from the system would result in a sharp reduction of the cost of the system and, thereby, will make incentives for the end-users to adopt the solution. This novel system will not only supply the buildings' real-time electricity and domestic hot water needs but also will compensate for a significant portion of the buildings' energy expenses by selling the surplus generations to the electricity and heat networks. The dynamic model of the proposed system is comprehensively analyzed from thermodynamic and economic points of view using TRNSYS software. Additionally, defining the overall annual exergy efficiency, and the total product cost as the objective functions, optimization of the design and size of the system employing the TRNOPT tool has been done. It is shown that the optimized system results in 16.7 (sic)/MWh and 7.7 (sic)/MWh lower energy costs for electricity and heat of the buildings compared to when the buildings' demand is only supplied by heat and electricity grids.
Circ_0017639 facilitates proliferative, migratory, and invasive potential of non-small cell lung cancer (NSCLC) cells via PI3K/AKT signaling pathway

Non-small cell lung cancer (NSCLC) has increased morbidity and mortality rate worldwide. The current NSCLS therapies are associated with poor outcomes and need further improvement. CircRNAs were shown to regulate NSCLC progression. However, little is known re garding the functions and mechanisms of circ_0017639 in NSCLC, which requires further extensive studies. The circ_0017639 expression in NSCLC tissues and cell lines was evaluated via qRT-RCR. Moreover, using ectopic plasmid incorporation and shRNA assays, we analyzed the circ_0017639-mediated cellular proliferative, migratory and invasive processes in NSCLC cell lines, using CCK-8, EdU, and transwell assays. Furthermore, the core proteins (p-PI3K, PI3K, p-AKT, and AKT) levels of the PI3K/AKT signaling cascade were investigated via immunoblotting. Finally, we tested the functional role of circ_0017639 by examining its regulation of xenograft tumor growths in nude mice in vivo. Circ_0017639 expression was remarkably high in the NSCLC tissues and cell lines. The transfection experiments showed that circ_0017639 overexpression was able to promote proliferative, migratory, and invasive properties of NSCLC cells, while sh-circ_0017639 showed opposing effects. We further showed that circ_0017639 knockdown suppressed the cellular development via PI3K/AKT cascade inactivation. Additionally, in-vivo experiment in nude mice demonstrated that sh-circ_0017639 could reduce the tumor growth of NSCLC. Circ_0017639 may promote the development of NSCLC by accelerating NSCLC metastasis through stimulating the PI3K/AKT cascade.
Sinonasal Plasmablastic Lymphoma Arising in the Setting of Recurrent Nasal Polyposis in an Immunocompetent Individual

Plasmablastic lymphoma (PBL) is an aggressive, rare variant of B-cell lymphoma typically associated with human immunodeficiency virus and other immunocompromised populations. Most commonly found in the oral cavity, PBL can occasionally originate in the sinonasal tract. Diagnosis of PBL is difficult due to overlapping features with other malignancies; however, early detection and treatment are imperative given its aggressive clinical course. When in the sinonasal tract, the diagnostic process can be further complicated if the patient has a history of recurrent nasal polyposis. Described is the case of a 57-year-old immunocompetent male who initially presented with benign nasal polyposis, only to return a year after sinus surgery with a unilateral sinonasal mass consistent with PBL. As literature has yet to characterize this phenomenon, this article presents the first case reported of sinonasal PBL arising in the setting of recurrent nasal polyposis. This case emphasizes the importance of investigating sinonasal masses showing laterality, maintaining a high index of suspicion for malignancy, and keeping close surveillance of the patient after treatment of PBL.