ahmedabdelwahed/Medical_papers_title_and_abstract_NLP_dataset huggingface dataset:
The Importance and Quantification of Plutonium Binding in Human Lungs

Epidemiological studies have shown that the main risk arising from exposure to plutonium aerosols is lung cancer, with other detrimental effects in the bone and liver. A realistic assessment of these risks, in turn, depends on the accuracy of the dosimetric models used to calculate doses in such studies. A state-of-the-art biokinetic model for plutonium, based on the current International Commission on Radiological Protection biokinetic model, has been developed for this purpose in an epidemiological study involving the plutonium exposure of Mayak workers in Ozersk, Russia. One important consequence of this model is that the lung dose is extremely sensitive to the fraction (f(b)) of plutonium, which becomes bound to lung tissue after it dissolves. It has been shown that if just 1% of the material becomes bound in the bronchial region, this will double the lung dose. Furthermore, f(b) is very difficult to quantify from experimental measurements. This paper summarizes the work carried out thus far to quantify f(b). Bayesian techniques have been used to analyze data from different sources, including both humans and dogs, and the results suggest a small, but nonzero, fraction of < 1%. A Bayesian analysis of 20 Mayak workers exposed to plutonium nitrate suggests an f(b) between 0 and 0.3%. Based on this work, the International Commission on Radiological Protection is currently considering the adoption of a value of 0.2% for the default bound fraction for all actinides in its forthcoming recommendations on internal dosimetry. In an attempt to corroborate these findings, further experimental work has been carried out by the US Transuranium and Uranium Registries. This work has involved direct measurements of plutonium in the respiratory tract tissues of workers who have been exposed to soluble plutonium nitrate. Without binding, one would not expect to see any activity remaining in the lungs at long times after exposure since it would have been cleared by the natural process of mucociliary clearance. Further supportive study of workers exposed to plutonium oxide is planned. This paper ascertains the extent to which these results corroborate previous inferences concerning the bound fraction.
State of the art in the application of QSAR techniques for predicting mixture toxicity in environmental risk assessment

The focus of regulatory chemical risk assessment has been mainly placed on single chemicals rather than mixtures. However, living organisms and the environment might be exposed to mixtures of chemicals. Many scientific studies have revealed that mixture toxicity can arise from the combined effects of components present at levels below their individual no-effect concentrations. Predictive approaches will be essential for estimating mixture toxicity, as the number of possible mixtures is extremely large. Although predictive models are virtually indispensable for estimating mixture toxicity for both scientific and regulatory purposes, risk assessors encounter substantial difficulties in using conventional models, mainly due to the lack of information on the modes of toxic action of the mixture constituents. Alternative models that use different information instead of the modes of action thus need to be developed. The objective of this study is to investigate the state of the art in predictive models based on quantitative structure-activity relationship techniques for estimating the toxicity of mixture components, and to identify future challenges hindering more reliable mixture risk assessment for environmental risk assessment. Alternative models need to be developed not only to overcome the limitations of conventional models, but also to improve their performance.
Advanced Simulation of Quantum Computations

Quantum computation is a promising emerging technology which, compared to conventional computation, allows for substantial speed-ups, e.g., for integer factorization or database search. However, since physical realizations of quantum computers are in their infancy, a significant amount of research in this domain still relies on simulations of quantum computations on conventional machines. This causes a significant complexity which current state-of-the-art simulators try to tackle with a rather straight forward array-based representation and by applying massive hardware power. There also exist solutions based on decision diagrams (i.e., graph-based approaches) that try to tackle the exponential complexity by exploiting redundancies in quantum states and operations. However, these existing approaches do not fully exploit redundancies that are actually present. In this paper, we revisit the basics of quantum computation, investigate how corresponding quantum states and quantum operations can be represented even more compactly, and, eventually, simulated in a more efficient fashion. This leads to a new graph-based simulation approach which outperforms state-of-the-art simulators (array-based as well as graph-based). Experimental evaluations show that the proposed solution is capable of simulating quantum computations for more qubits than before, and in significantly less run-time (several magnitudes faster compared to previously proposed simulators). An implementation of the proposed simulator is publicly available online at http://www.jku.at/iic/eda/quantum_simulation.
[Engage health and medico-social institutions in a sustainable development or CSR approach]

Health and medico-social establishments have every interest in embarking on corporate social responsibility for establishments: decarbonisation, compliance with regulations, attractiveness strategy, links with territorial partners, economic interest, etc. To support them, the Fédération hospitalière de France has put forward proposals to the presidential candidates, which are intended to be supported throughout Emmanuel Macron's new five-year term.
Rhodotorula sp.-based biorefinery: a source of valuable biomolecules

The development of an effective, realistic, and sustainable microbial biorefinery depends on several factors, including as one of the key aspects an adequate selection of microbial strain. The oleaginous red yeast Rhodotorula sp. has been studied as one powerful source for a plethora of high added-value biomolecules, such as carotenoids, lipids, and enzymes. Although known for over a century, the use of Rhodotorula sp. as resource for valuable products has not yet commercialized. Current interests for Rhodotorula sp. yeast have sparked from its high nutritional versatility and ability to convert agro-food residues into added-value biomolecules, two attractive characteristics for designing new biorefineries. In addition, as for other yeast-based bioprocesses, the overall process sustainability can be maximized by a proper integration with subsequent downstream processing stages, for example, by using eco-friendly solvents for the recovery of intracellular products from yeast biomass. This review intends to reflect on the current state of the art of microbial bioprocesses using Rhodotorula species. Therefore, we will provide an analysis of bioproduction performance with some insights regarding downstream separation steps for the extraction of high added-value biomolecules (specifically using efficient and sustainable platforms), providing information regarding the potential applications of biomolecules produced by Rhodotorula sp, as well as detailing the strengths and limitations of yeast-based biorefinery approaches. Novel genetic engineering technologies are further discussed, indicating some directions on their possible use for maximizing the potential of Rhodotorula sp. as cell factories. KEY POINTS: • Rhodotorula sp. are valuable source of high value-added compounds. • Potential of employing Rhodotorula sp. in a multiple product biorefinery. • Future perspectives in the biorefining of Rhodotorula sp. were discussed.
Fifty Years of Acoustic Feedback Control: State of the Art and Future Challenges

The acoustic feedback problem has intrigued researchers over the past five decades, and a multitude of solutions has been proposed. In this survey paper, we aim to provide an overview of the state of the art in acoustic feedback control, to report results of a comparative evaluation with a selection of existing methods, and to cast a glance at the challenges for future research.
Are morphological changes necessary to mediate the therapeutic effects of electroconvulsive therapy?

The neurotrophic hypothesis has become the favorite model to explain the antidepressant properties of electroconvulsive therapy (ECT). It is based on the assumption that a restoration of previously defective neural networks drives therapeutic effects. Recent data in rather young patients suggest that neurotrophic effects of ECT might be detectable by diffusion tensor imaging. We here aimed to investigate whether the therapeutic response to ECT necessarily goes along with mesoscopic effects in gray matter (GM) or white matter (WM) in our patients in advanced age. Patients (n = 21, 15 males and 7 females) suffering from major depressive disorder were treated with ECT. Before the start of treatment and after the completion of the index series, they underwent magnetic resonance imaging, including a diffusion-weighed sequence. We used voxel-based morphometry to assess GM changes and tract-based spatial statistics and an SPM-based whole-brain analysis to detect WM changes in the course of treatment. Patients significantly improved clinically during the course of ECT. This was, however, not accompanied by GM or WM changes. This result challenges the notion that mesoscopic brain structure changes are an obligatory prerequisite for the antidepressant effects of ECT.
Conceptual framework for designing agri-food supply chains under uncertainty by mathematical programming models

Agri-food sector performance strongly impacts global economy, which means that developing optimisation models to support the decision-making process in agri-food supply chains (AFSC) is necessary. These models should contemplate AFSC's inherent characteristics and sources of uncertainty to provide applicable and accurate solutions. To the best of our knowledge, there are no conceptual frameworks available to design AFSC through mathematical programming modelling while considering their inherent characteristics and sources of uncertainty, nor any there literature reviews that address such characteristics and uncertainty sources in existing AFSC design models. This paper aims to fill these gaps in the literature by proposing such a conceptual framework and state of the art. The framework can be used as a guide tool for both developing and analysing models based on mathematical programming to design AFSC. The implementation of the framework into the state of the art validates its. Finally, some literature gaps and future research lines were identified.
Road Centerline Extraction via Semisupervised Segmentation and Multidirection Nonmaximum Suppression

Accurate road centerline extraction from remotely sensed images plays a significant role in road map generation and updating. In the road extraction problem, the acquisition of labeled data is time consuming and costly; thus, there are only a small amount of labeled samples in reality. In the existing centerline extraction algorithms, the thinning-based algorithms always produce small spurs that reduce the smoothness and accuracy of the road centerline; the regression-based algorithms can extract a smooth road network, but they are time consuming. To solve the aforementioned problems, we propose a novel road centerline extraction method, which is constructed based on semi-supervised segmentation and multiscale filtering (MF) and multidirection nonmaximum suppression (M-NMS) (MF&M-NMS). Specifically, a semisupervised method, which explores the intrinsic structures between the labeled samples and the unlabeled ones, is introduced to obtain the segmentation result. Then, a novel MF&M-NMS-based algorithm is proposed to gain a smooth and complete road centerline network. Experimental results on a public data set demonstrate that the proposed method achieves comparable or better performances by comparing with the stateof-the-art methods. In addition, our method is nearly ten times faster than the state-of-the-art methods.
Protective effects of probiotics against tannin-induced immunosuppression in broiler chickens

Tannins (TAs) are an anti-nutritional substance commonly used as a natural feed additive for livestock. However, our previous study described the dose-dependent adverse effects of TA on immune responses and growth in chickens. In this study, we evaluated the protective effects of a probiotic preparation (BT) consisting of three different bacteria (Bacillus mesenteric, Clostridium butyricum, and Streptococcus faecalis) against TA-induced immunosuppression in chickens. Forty chicks were divided into 4 groups as follows: the CON group (basal diet), BT group supplemented with 3 g BT/kg diet, tannic acid (TA) group supplemented with 30 g TA/kg diet, and BT+TA group supplemented with 3 g BT/kg diet + 30 g TA/kg diet. The feeding trial lasted for 35 days. Lymphocyte subset, macrophage phagocytosis, cytokine mRNA expression, and primary and secondary IgY immune responses were evaluated. BT supplementation significantly improved TA-induced reductions in final body weight, body weight gain, feed intake, and relative weights of lymphoid organs compared with the TA group. Furthermore, in the spleen and cecal tonsil (CT), the relative populations of CD4+, CD8+, and CD4+CD8+ cells in the BT+TA group were significantly ameliorated compared with the TA group. Additionally, comparison with the TA group showed that the chickens in the BT+TA group had an improved relative population of B cells in the CT and that macrophage phagocytosis in the spleen was significantly increased. Chickens in the BT+TA group showed significant increases in IFN-γ and IL-4 mRNA expression in the spleen compared with the TA group. The primary and secondary IgY responses were significantly improved. These results revealed that supplementation with BT protects against TA-induced immunosuppression in chickens.
Evaluation of peripheral nerve regeneration in Murphy Roths Large mouse strain following transection injury

Aim: Murphy Roths Large (MRL/MpJ) mice have demonstrated the ability to heal with minimal or no scar formation in several tissue types. In order to identify a novel animal model, this study sought to evaluate whether this attribute applies to peripheral nerve regeneration. Materials & methods: This was a two-phase study. 6-week-old male mice were divided into two interventional groups: nerve repair and nerve graft. The MRL/MpJ was compared with the C57BL/6J strain for evaluation of both functional and histological outcomes. Results: MRL/MpJ strain demonstrated superior axon myelination and less scar formation, however functional outcomes did not show significant difference between strains. Conclusion: Superior histological outcomes did not translate into superior peripheral nerve regeneration in MRL/MpJ strain.
Audio Inpainting

We propose the audio inpainting framework that recovers portions of audio data distorted due to impairments such as impulsive noise, clipping, and packet loss. In this framework, the distorted data are treated as missing and their location is assumed to be known. The signal is decomposed into overlapping time-domain frames and the restoration problem is then formulated as an inverse problem per audio frame. Sparse representation modeling is employed per frame, and each inverse problem is solved using the Orthogonal Matching Pursuit algorithm together with a discrete cosine or a Gabor dictionary. The Signal-to-Noise Ratio performance of this algorithm is shown to be comparable or better than state-of-the-art methods when blocks of samples of variable durations are missing. We also demonstrate that the size of the block of missing samples, rather than the overall number of missing samples, is a crucial parameter for high quality signal restoration. We further introduce a constrained Matching Pursuit approach for the special case of audio declipping that exploits the sign pattern of clipped audio samples and their maximal absolute value, as well as allowing the user to specify the maximum amplitude of the signal. This approach is shown to outperform state-of-the-art and commercially available methods for audio declipping in terms of Signal-to-Noise Ratio.
Synergistic polymorphic interactions of phase II metabolizing genes and their association toward lung cancer susceptibility in North Indians

Lung cancer is a multifactorial carcinoma with diverse heterogeneity. Genetic variations in drug-metabolizing enzymes may lead to defective detoxification and clearance of carcinogenic compounds. The high-order gene-gene interaction has been carried out between different genotypes of Phase II detoxification genes (NQO1, SULT1A1, NAT2, and EPHX1). Our results depict the genetic combination of SULT1A1 R213H with NAT2 × 5B L161L, SULT1A1 R213H with NAT2 × 5C K268R, EPHX1 H139R and NAT2 × 5B L161L exhibit a protective effect towards lung cancer risk. Further, the triple combinations of NQO1 P187S, EPHX1 Y113H, and EPHX1 H139R; NQO1 P187S, EPHX1 Y113H, and NAT2 × 6 R197Q; NQO1 P187S, EPHX1 Y113H, and NAT2 × 7 G286E; SULT1A1 R213H, EPHX1 H139R, and NAT2 × 7 G286E suggested a two-fold increased risk of lung cancer for subjects. Genetic polymorphisms of phase II detoxifying genes (NAT2, NQO1, EPHX1, SULT1A1) are prognostic markers for lung cancer.
Social interaction can select for reduced ability

Animals, including humans, differ in a wide range of physical and cognitive abilities ranging from measures of running speed and physical strength to learning ability and intelligence. We consider the evolution of ability when individuals interact pairwise over their contribution to a common good. In this interaction, the contribution of each is assumed to be the best given their own ability and the contribution of their partner. Since there is a tendency for individuals to partially compensate for a low contribution by their partner, low-ability individuals can do well. As a consequence, for benefit and cost structures for which individuals have a strong response to partner's contribution, there can be selection for reduced ability. Furthermore, there can be disruptive selection on ability, leading to a bimodal distribution of ability under some modes of inheritance.
A prospective analysis of red blood cell membrane polyunsaturated fatty acid levels and risk of non-Hodgkin lymphoma

Published studies report inconsistent associations of polyunsaturated fatty acid (PUFA) intake with non-Hodgkin lymphoma (NHL) risk. We conducted a nested case-control study in Nurses' Health Study and Health Professionals Follow-Up Study participants to evaluate a hypothesis of inverse association of pre-diagnosis red blood cell (RBC) membrane PUFA levels with risk of NHL endpoints. We confirmed 583 NHL cases and matched 583 controls by cohort/sex, age, race and blood draw date/time. We estimated odds ratios (OR) and 95% confidence intervals (CI) for risk of NHL endpoints using logistic regression. RBC PUFA levels were not associated with all NHL risk; cis 20:2n-6 was associated with follicular lymphoma risk (OR [95% CI] per one standard deviation increase: 1.35 [1.03-1.77]), and the omega-6/omega-3 PUFA ratio was associated with diffuse large B-cell lymphoma risk (2.33 [1.23-4.43]). Overall, PUFA did not demonstrate a role in NHL etiology; the two unexpected positive associations lack clear biologic explanations.
Vestibular paroxysmia entails vestibular nerve function, microstructure and endolymphatic space changes linked to root-entry zone neurovascular compression

Combining magnetic resonance imaging (MRI) sequences that permit the determination of vestibular nerve angulation (NA = change of nerve caliber or direction), structural nerve integrity via diffusion tensor imaging (DTI), and exclusion of endolymphatic hydrops (ELH) via delayed gadolinium-enhanced MRI of the inner ear (iMRI) could increase the diagnostic accuracy in patients with vestibular paroxysmia (VP). Thirty-six participants were examined, 18 with VP (52.6 ± 18.1 years) and 18 age-matched with normal vestibulocochlear testing (NP 50.3 ± 16.5 years). This study investigated whether (i) NA, (ii) DTI changes, or (iii) ELH occur in VP, and (iv) to what extent said parameters relate. Methods included vestibulocochlear testing and MRI data analyses for neurovascular compression (NVC) and NA verification, DTI and ELS quantification. As a result, (i) NA increased NVC specificity. (ii) DTI structural integrity was reduced on the side affected by VP (p < 0.05). (iii) 61.1% VP showed mild ELH and higher asymmetry indices than NP (p > 0.05). (iv) "Disease duration" and "total number of attacks" correlated with the decreased structural integrity of the affected nerve in DTI (p < 0.001). NVC distance within the nerve's root-entry zone correlated with nerve function (Roh = 0.72, p < 0.001), nerve integrity loss (Roh = - 0.638, p < 0.001), and ELS volume (Roh = - 0.604, p < 0.001) in VP. In conclusion, this study is the first to link eighth cranial nerve function, microstructure, and ELS changes in VP to clinical features and increased vulnerability of NVC in the root-entry zone. Combined MRI with NVC or NA verification, DTI and ELS quantification increased the diagnostic accuracy at group-level but did not suffice to diagnose VP on a single-subject level due to individual variability and lack of diagnostic specificity.
Andean caravan ceremonialism in the lowlands of the Atacama Desert: The Cruces de Molinos archaeological site, northern Chile

Camelid caravans have played a key role in the complex systems of interregional social interaction that characterizes Andean history. In the northernmost region of Chile, the most frequent archaeological indicators of these caravan systems are trails and rock art images. Cruces de Molinos (LL-43), a rock art site in the Lluta valley, 1100 masl, 40 km from the Pacific littoral, expands the ceremonial role of rock art sites, materialized, not only as regards the iconography portrayed and alluding to these practices, but also in terms of articulated carcass remains and detached anatomical units of camelids, intentionally deposited in a cache beneath one of the engraved blocks. This paper analyzes the site considering the visual imagery, spatial location, archaeological deposits and features associated with rock art. Based on the predominance of camelid and caravan motifs in rock art images, the extraordinary setting and location of the site on the valleys upper slopes, which is far removed from local settlements, but closely connected with a llama caravan trade network linking the chaupiyunga ecozone with the highlands (sierra and Altiplano ecozones), we suggest that Cruces de Molinos was not a rest stop for caravanners, but a ceremonial place, and not for local farmers, but for highland herders. According to seven accelerator mass spectrometry (AMS) dates that place the occupation between cal. 1060-1190 CE in the Late Intermediate period.