ahmedabdelwahed/Medical_papers_title_and_abstract_NLP_dataset huggingface dataset:
Mixture Phases Engineering of PtFe Nanofoams for Efficient Hydrogen Evolution

Phase engineering is a promising but challenging approach to construct PtFe-based catalysts with efficient hydrogen evolution reaction (HER) performance. Herein, the authors successfully synthesize PtFe nanofoams with face center cubic (fcc) phase, with simple cubic crystalline (scc) phase and with the mixture phases of fcc and scc phases (PtFe-mix) by hydrogen-assisted calcination for the first time. By benchmarking the HER activity, PtFe-mix exhibits excellent activity in 1.0 m KOH, requiring an overpotential of 28 mV to achieve 10 mA cm-2 , which is better than the commercial Pt/C (34 mV). PtFe-mix also possesses remarkable stability up to 24 h. Density functional theory calculations further verify that PtFe-mix shows a more suitable d-band center and lower energy barrier for the initial water dissociation, facilitating the HER process. This work provides a meaningful strategy to design PtFe-based catalysts with efficient activity for hydrogen evolution.
Agonism and grooming behaviour explain social status effects on physiology and gene regulation in rhesus macaques

Variation in social status predicts molecular, physiological and life-history outcomes across a broad range of species, including our own. Experimental studies indicate that some of these relationships persist even when the physical environment is held constant. Here, we draw on datasets from one such study-experimental manipulation of dominance rank in captive female rhesus macaques-to investigate how social status shapes the lived experience of these animals to alter gene regulation, glucocorticoid physiology and mitochondrial DNA phenotypes. We focus specifically on dominance rank-associated dimensions of the social environment, including both competitive and affiliative interactions. Our results show that simple summaries of rank-associated behavioural interactions are often better predictors of molecular and physiological outcomes than dominance rank itself. However, while measures of immune function are best explained by agonism rates, glucocorticoid-related phenotypes tend to be more closely linked to affiliative behaviour. We conclude that dominance rank serves as a useful summary for investigating social environmental effects on downstream outcomes. Nevertheless, the behavioural interactions that define an individual's daily experiences reveal the proximate drivers of social status-related differences and are especially relevant for understanding why individuals who share the same social status sometimes appear physiologically distinct. This article is part of the theme issue 'The centennial of the pecking order: current state and future prospects for the study of dominance hierarchies'.
Incidental Finding of an Aspergillus Pseudoaneurysm in the Ascending Aorta of an Immunocompetent Patient

Pseudoaneurysms of the ascending aorta are rare, yet they are life-threatening conditions and usually associated with poor outcomes due to insidious presentation. Many different etiologies have been associated with aortic pseudoaneurysms including; atherosclerosis, infections, connective tissue disorders, and traumatic causes. In addition, aortic pseudoaneurysms have been reported following thoracic surgeries, including aortic valve replacements, aortic dissection repair, and coronary artery bypass grafting. Aspergillus is amongst the infectious etiologies of pseudoaneurysms. Aspergillus species is a ubiquitous mold (fungus) that is mostly harmless but may result in serious illnesses in immunocompromised hosts with hematologic neoplasms, neutropenia, or immunodeficiency syndromes. In this paper, we report a case of an ascending aortic pseudoaneurysm caused by Aspergillus infection. To our knowledge, this is an exceptionally rare case diagnosed incidentally in an immunocompetent patient, who is surgically free and without any pre-existing risk factors.
Motor neuron involvement expands the neuropathological phenotype of late-onset ataxia in RFC1 mutation (CANVAS)

Neuropathological features in brainstem, cerebellum and spinal cord. In addition to cerebellar, vestibullar nuclei and spinal cord posterior columns involvement, a moderate reduction of motor neurons in hypoglossal nucleus and anterior horn of the thoracic spinal cord was present.
The role of institutional quality in FDI inflows and carbon emission reduction: evidence from the global developing and belt road initiative countries

Achieving economic growth is the primary concern mostly of every country to enhance living standard; however, an increase in economic activities may have environmental consequences. Foreign direct investment is also considered a driver of economic growth while it affects the quality of environment. The role of institutions can be useful to enhance foreign direct investment (FDI) inflow which can in turn increase economic growth and safeguard environmental quality. Based on the ongoing debate, this study attempts whether the quality of institutions plays any role in FDI inflow and in enhancement of environmental quality. For this purpose, this study examines the role of institutional quality in FDI inflows and carbon emission reduction in the global panel, 107 world developing, and 39 Belt and Road Initiative countries for the period of 2002-2019. By using both static and dynamic panel models, the results indicate that governance indicators are important for FDI inflows, but this impact varies in different panels. Overall, institutional quality has a significant and positive impact on foreign direct investment inflow, while energy use reduces it in all panels. Economic growth positively associated with carbon emission, while the square of GDP evidences the environmental Kuznets curve. FDI and trade increase global and developing countries' emissions, while reducing emission in Belt and Road countries. Institutional quality along individual indicators, political stability, rule of law, and regulatory quality are found to be poor governance indicators in all panels, while voice and accountability and control of corruption are weak indicators in Belt and Road countries; however, the interaction term proves that the quality of institutions is regulated by financial development and FDI in carbon emission reduction in all panels. This study has considerable policy significance for countries to carry out strong policy reforms to increase green FDI and improve environmental quality.
Heavy metal pollution risk assessments and their transportation in sediment and overlay water for the typical Chinese reservoirs

To assess the metals (Cr, Mn, Cu, Zn, Cd, Hg and Pb) pollution risks and their transportation in sediment and overlay water from the typical reservoirs in the rapidly developing economic region of southeastern China, this study integrated an intact sediment core incubation and the sediment metals vertical distribution analysis in a drinking water reservoir (Drinking-Y) and an irrigation water reservoir (Irrigation-T). The results revealed that both studied reservoirs were severely polluted by heavy metals. Irrigation-T was at a considerable risk compared to Drinking-Y (a moderate or slightly considerable risk) reflecting higher concentration of metals in Irrigation-T versus Drinking-Y. Concentrations of Hg and Cd in the overlying water exceeded the World Health Organization (WHO) standard, contributing approximately 90% of the total potential ecological risk index (RI) for both metals in the sediment. Most of the metals continue to increase inputs into the reservoirs and metals can settle from water to sediment in 10-15 days by static incubation. The main anthropogenic pollution sources originated from fuel combinations and industry mills (6.4%) and agricultural activities (38%) for Drinking-Y and fuel combinations and industry mills (4.9%), agricultural activities (32.9%) and mines and quarries (62.1%) for Irrigation-T. To reduce the human health risks, therefore, the freshwater should be stored 10-15 days prior to drinking or irrigation. Our data indicated that all the current pollution sources require more attention for further reducing the human health risks.
Depression in the house: The effects of household air pollution from solid fuel use among the middle-aged and older population in China

Background: Although the adverse health effects of ambient air pollution are well documented, evidence on the depression effects of household air pollution (HAP) are scarce. Objectives: We investigated the effects of HAP exposure from the use of solid fuel on depression using a nationally representative dataset of middle-aged and older population in China. Methods: By employing the propensity score matching method, we first matched the type of household fuel based on background information, including demographic characteristics, lifestyles, health status, and household economic levels. Based on the matched data, we conducted OLS and logistic regressions with cluster standard error at community level to examine the effects of household solid fuel use on depression and adjusted for potential confounders. Heterogeneous effects for vulnerable population were also considered. Results: We found a significantly higher Center for Epidemiologic Studies Depression Scale (CES-D) score and depression risk among current household solid fuel users. After matching and adjusting for potential confounders, current solid fuel users had a higher CES-D score of 0.59 (95% confidence interval [CI]: 0.31, 0.89) than clean fuel users. The OR of depression risk were 1.26 (95% CI: 1.14, 1.41). Solid fuel users had the highest CES-D scores (beta = 0.99, 95% CI: 0.62, 1.36) and depression risk (OR = 1.49, 95% CI: 1.30, 1.73) for over five years. These associations were generally higher in females, participants aged 65 years and older, with a BMI >= 25, with low education, with low household economic levels, and those suffer from chronic diseases, including diabetes, chronic lung diseases, and cardiovascular diseases. Conclusions: Exposure to HAP from solid fuel combustion was linked with strong depression outcomes. Findings suggested a need to strengthen public health efforts, such as controlling the social, health, and economic costs of depression by taking the physical environment, including HAP exposure, into account. (C) 2019 Elsevier B.V. All rights reserved.
Effects of PM2.5 on health and economic loss: Evidence from Beijing-Tianjin-Hebei region of China

Rapid industrialization and urbanization have triggered severe PM(2.5 )pollution and induced serious health hazards and economic losses in densely populated regions. A substantial number of health-related economic loss assessment methods, which quantify economic losses caused by diverse health endpoints, have been applied. However, traditional models neglect pollutant distribution and optimization of distribution parameters, which may lead to poor estimation accuracy. In this study, a health-related economic loss evaluation system is proposed, which deals with PM2.5 distribution, optimization of distribution parameters, and evaluation of health-related economic losses. This assessment system efficiently simulated the characteristic of PM2.5 concentrations in three cities of the Beijing-Tianjin-Hebei region and addressed economic losses estimation problems. The results indicate that the system not only provides a novel perspective on health-related economic loss assessment, but also assists policymakers in its practical application. (C) 2020 Elsevier Ltd. All rights reserved.
S100B in cardiac surgery brain monitoring: friend or foe?

Recent advances in perioperative management of adult and pediatric patients requiring open heart surgery (OHS) and cardiopulmonary bypass (CPB) for cardiac and/or congenital heart diseases repair allowed a significant reduction in the mortality rate. Conversely morbidity rate pattern has a flat trend. Perioperative period is crucial since OHS and CPB are widely accepted as a deliberate hypoxic-ischemic reperfusion damage representing the cost to pay at a time when standard of care monitoring procedures can be silent or unavailable. In this respect, the measurement of neuro-biomarkers (NB), able to detect at early stage perioperative brain damage could be especially useful. In the last decade, among a series of NB, S100B protein has been investigated. After the first promising results, supporting the usefulness of the protein as predictor of short/long term adverse neurological outcome, the protein has been progressively abandoned due to a series of limitations. In the present review we offer an up-dated overview of the main S100B pros and cons in the peri-operative monitoring of adult and pediatric patients.
Mission-oriented innovation systems

Rather than merely supporting R&D and strengthening innovation systems, the focus of innovation policy is currently shifting towards addressing societal challenges by transforming socio-economic systems. A particular trend within the emerging era of transformative innovation policy is the pursuit of challenge-based innovation missions, such as achieving a 50 % circular economy by 2030. By formulating clear and ambitious societal goals, policy makers are aiming to steer the directionality and adoption of innovation. In the absence of suitable frameworks to understand and enhance the impact of missions, we introduce the notion of Mission-oriented Innovation Systems (MIS). MIS consists of networks of agents and sets of institutions that contribute to the development and diffusion of innovative solutions with the aim to define, pursue and complete a societal mission. We provide several promising research avenues, including how MIS come into existence, how they are governed and how the interactions taking place in a MIS may influence directionality and technological variety.
Are Trade Liberalization policies aligned with Renewable Energy Transition in low and middle income countries? An Instrumental Variable approach

This paper attempts to empirically analyze the compatibility of national trade liberalization policies with regards to promoting widespread use of renewable energy resources across 71 low, lower-middle and upper-middle income countries from South Asia, East Asia, Pacific, Central Asia, Latin America, Caribbean islands and Sub-Saharan Africa. Annual time series data from 2000 to 2017 is employed to perform panel data cointegration and regression analyses. The results from the cointegration analyses show long-run associations between trade liberalization policies and the renewable energy consumption indicators. The Instrumental Variable Two-Stage Least Squares panel data estimator is employed to control for the endogeneity in the dataset. The overall results broadly point towards the effectiveness of greater trade openness in facilitating renewable energy transition only in the low-income economies while prolonging the transition periods in the lower and upper-middle income countries. The marginal impact of a rise in the trade openness index is estimated to enhance the renewable energy share in total energy consumption within low-income countries by 0.24% as opposed to lowering this share by 0.19% within lower-middle income economies. However, trade liberalization is found to attribute to greater efficiency of renewable energy use across all the three income groups. Thus, these findings have critically important policy implications for the respective governments. (C) 2019 Elsevier Ltd. All rights reserved.
Built environment design - social sustainability relation in urban renewal

Urban renewal practices could improve urban social sustainability with well-designed and well-constructed built environments. This study shows the development of a model, which explains the relation between built environment design and social sustainability in urban renewal. To do so, firstly, a comprehensive literature review was conducted, after which a pilot study was administered. This led to the identification of 32 built environment design elements. Their contributions to social sustainability were evaluated utilizing a survey among 323 people who previously worked in urban renewal projects. The design elements were grouped by exploratory factor analysis under five factors, and these factors were named as, accessibility and quality of social life, conservation of resources, quality of the built environment, protection of disadvantaged groups, and commercial and economic opportunities. Then, the analytic hierarchy process (AHP) was carried out with 60 academics and practitioners to identify the weights of the factors. Accessibility and quality of social life factor reached the highest weight with 33 %, while the other four factors shared close weights. The model obtained as a result of this study will increase the awareness of urban renewal stakeholders about social sustainability, by demonstrating clearly which design elements should be considered to improve the social sustainability of urban renewal projects.
The use of analgesics and associated factors among nursing home residents

Aim: This study examined the use of analgesics and associated factors among nursing home residents (NHRs). Materials & methods: A descriptive correlational design and a convenience sample of 209 NHRs receiving analgesics was used in this study. Results: Higher use of analgesics was noted among NHRs without cognitive impairment (p < 0.001), those with higher anticholinergic burden scores (p = 0.002) and those with a higher average number of oral pills taken daily (p = 0.045). Conclusion: These findings contribute to a better understanding of the prevalence and associated factors of analgesic use, which will inform the development and application of evidence-based pain practice and guidelines in nursing homes in Jordan and beyond.
An essential review of Singapore's response to out-of-hospital cardiac arrests: improvements over a ten-year period

Care for patients who experience out-of-hospital cardiac arrest (OHCA) has rapidly evolved in the past decade. Increased sophistication of care in the community, emergency medical services (EMS) and hospital setting is associated with improved patient-centred outcomes. Notably, Utstein survival doubled from 11.6% to 23.1% between 2011 and 2016. These achievements involved collaboration between policymakers, clinicians and researchers, and were made possible by a strategic interplay of policy, research and implementation. We review the development and current state of OHCA in Singapore using primary population-based data from the Pan-Asian Resuscitation Outcomes Study and an unstructured search of research databases. We discuss the roles of important milestones in policy, community, dispatch, EMS and hospital interventions. Finally, we relate these interventions to relevant processes and outcomes, such as the relationship between the strategic implementation of bystander cardiopulmonary resuscitation and placement of automated external defibrillator with return of spontaneous circulation, survival to discharge and survival with favourable neurological outcomes.
High carriage of plasmid-mediated quinolone resistance (PMQR) genes by cefotaxime-resistant Escherichia coli recovered from surface-leaking sanitary sewers

There is a rapid rise in the incidence of quinolone resistant bacteria in Nigeria. Most studies in Nigeria have focused on isolates from the clinical settings, with few focusing on isolates of environmental origin. This study aimed to investigate the antibiogram and carriage of plasmid-mediated quinolone resistance (PMQR) genes by quinolone-resistant isolates obtained from a pool of cefotaxime-resistant Escherichia coli (E. coli) recovered from sewage leaking out of some surface-leaking sanitary sewers in a University community in Nigeria. Isolation of E. coli from the sewage samples was done on CHROMagar E. coli, after enrichment of the samples was done in Brain Heart Infusion broth amended with 6 µg/mL of cefotaxime. Identification of presumptive E. coli was done using molecular methods (detection of uidA gene), while susceptibility to antibiotics was carried out using the disc diffusion method. Detection of PMQR genes (qnrA, qnrB, qnrS, aac(6')-lb-cr, qepA and oqxAB) was carried out using primer-specific PCR. A total of 32 non-repetitive cefotaxime-resistant E. coli were obtained from the sewage, with 21 being quinolone-resistant. The quinolone-resistant isolates showed varying level of resistance to the tested antibiotics, with imipenem being the only exception with 0% resistance. The PMQR genes: aac(6')-lb-cr, qnrA, qnrB, qnrS and qepA and oqxAB were detected in 90.5%, 61.9%, 47.6%, 38.1%, 4.8% and 0% respectively of the isolates. The findings of this study showed a high level of resistance to antibiotics and carriage of PMQR genes by quinolone-resistant E. coli obtained from the leaking sanitary sewers, suggesting a potential environmental and public health concern.
Regional renewable energy development in China: A multidimensional assessment

Renewable energy (RE) is strategically important to achieve sustainability. Its development in China, however, is clearly imbalanced across regions. The uneven distribution of natural resources, financial resources and other factors across this country has brought serious challenges to the policymakers. It is thus important to give a comprehensive evaluation of China's regional RE development. To do so, this paper introduces a multidimensional approach and establishes a quantitative evaluation framework. Based on the existing literature, five dimensions of factors have been chosen for the framwork: economic foundation, institutions, technological development potential, energy security and environmental protection, and current status of the RE sector. A dynamic principal component analysis technique is applied to data from 29 provinces between 2008 and 2014. The results demonstrate large variations in RE development across provinces in China. More economically developed regions, such as Beijing, Shanghai, and Guangdong, have maintained a higher ranking and have clear advantages in almost all dimensions. Policy implications and recommendations for more balanced development across China are drawn from the empirical results. This approach can also be extended to investigate similar issues in other countries.
Clinical value of routine [18F]2-fluoro-2-deoxy-d-glucose positron emission tomography scans as a decision tool for early immunotherapy discontinuation in advanced melanoma

Routine [18F]2-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) may help predict clinical outcomes after response to immunotherapy. With a European Medicines Agency-recommended treatment length until disease progression or unacceptable toxicity, the optimal duration of immunotherapy remains to be defined. In a retrospective study, we retrieved from the Danish Metastatic Melanoma Database (DAMMED), all patients that were annotated as a partial or complete response based on the computed tomography (CT) of serial FDG-PET-CT scans. Patients treated with an anti-Programmed Death (PD)-1-containing regimen for <18 months, and ≥4 months without disease progression after halting anti-PD-1 were included. Cases were divided into an "elective" and a "toxicity" group based on the reason for treatment discontinuation. A total of 140 patients were included. At 29.3 months of median follow-up, a higher proportion of patients remained alive in the "elective" group (93% vs 75%, P = .0031) with an improved melanoma-specific (HR 0.07, 95% CI 0.02-0.32, P = .0041) survival (MSS). Patients without FDG-avid lesions at the time of treatment discontinuation had an improved MSS (HR 0.03, 95% CI 0.01-0.17, P = .0002), and the absence of FDG-avid lesions was the only independent predictive feature of improved MSS in multivariate analysis. In conclusion, patients with metastatic melanoma who obtain an early response and early discontinue immunotherapy have an excellent prognosis, especially in the absence of FDG-PET avid lesions when discontinuing treatment. These data support the option of early discontinuation, limiting possible overtreatment and thereby toxicity, health and economic expenses and improving logistics.