ahmedabdelwahed/Medical_papers_title_and_abstract_NLP_dataset huggingface dataset:
Engineering of a protein probe with multiple inputs and multiple outputs for evaluation of alpha synuclein aggregation states

The aggregation of α-synuclein (αS) into oligomers and fibrils is implicated in the pathology of Parkinson's Disease (PD). While a molecular probe for rapid and comprehensive evaluation of αS aggregation states is critical for a better understanding of PD pathology, identification of therapeutic candidates, and the development of early diagnostic strategies, no such probe has yet to be developed. A structurally flexible αS variant, PG65, was previously developed as a target binding-driven, conformation-switching molecular probe for rapid αS oligomer detection. Though informative, detection using PG65 provides no comprehensive assessment of the αS aggregation states. In the present study, we report engineering of a molecular probe, PG65-MIMO (a PG65 variant with Multiple-Inputs and Multiple-Outputs), that rapidly (within 2 hr) produces comprehensive information on αS aggregation states. PG65-MIMO generates distinct fluorescence responses to the three major αS conformers (monomers, oligomers, and fibrils). PG65-MIMO also displays unique fluorescent signals for αS oligomers, depending on the tris(2-carboxyethyl)phosphine (TCEP) concentration. Our results suggest that the TCEP dependent signaling of PG65-MIMO may be associated with its conformational states. Overall, our study illustrates engineering of an αS variant to create a molecular probe for handling multiple inputs and multiple outputs, addressing the technological gap in αS detection.
Consumption-based carbon emissions and International trade in G7 countries: The role of Environmental innovation and Renewable energy

The role of a reliable carbon emissions measurement is important for devising a relevant climate policy to deals with environmental problems. Based on trade adjusted statistics of carbon emissions, a relevant climate policy response can be provided, especially following the conference of Paris (COP, 21). To explore the unidentified determinants of CO2 emissions in G7 countries from 1990 to 2017, this study uses second-generation panel co-integration methodologies. Results of P&Y's slope heterogeneity test and Pesaran's CD test confirm the existence of correlation among cross-sectional units and slope heterogeneity across countries. The results confirm a stable long-run relationship among CO2 emissions, trade, income, environmental innovation and renewable energy consumption. In the long run, imports and income enhance consumption-based carbon emissions, while exports, environmental innovation and renewable energy consumption are helpful in abating consumption-based CO2 emissions. The results are also reconfirmed by Augmented Mean Group (AMG) and Common Correlated Effect Mean Group (CCEMG) methods. Based on the results of the Dumitrescu and Hurlin (2012) Granger causality test, it is argued that any policy to target exports, imports, income and environmental innovation significantly changes CO2 emissions. On the contrary, any policy to support environmental degradation does not affect these variables. Moreover, any policy to target renewable energy sources significantly affects consumption-based CO2 emissions and vice versa. This might lead the policymakers to adopt strategies that are eco-friendly such as the deployment of renewable energy and environmental innovation to attain sustainable environment. (C) 2020 Elsevier B.V. All rights reserved.
The asymmetric effect of tourism, financial development, and globalization on ecological footprint in Turkey

With the growing interest among researchers in analyzing the ecological footprint of any country, this study focuses on new dimensions to analyze the long-run and short-run asymmetric impact of tourism, financial development, and globalization on ecological footprint in Turkey by using Quantile Autoregressive Distributed Lag model for the period from 1986 to 2018. Further, the EKC hypothesis was also tested. The results show that tourism, globalization, and financial development are positively and significantly associated with the EFP. This means that the increase in these variables will further increase the ecological footprint in Turkey. The U-shaped EKC curve was found to be valid in Turkey. The results also depict nonlinear and asymmetric association among most of the variables. Hence, based on the results, further research directions and practical implications can be suggested.
Biodiversity at disequilibrium: updating conservation strategies in cities

Greenspaces represent an ark for urban biodiversity, but understanding their carrying capacity to sustain species remains challenging. Old greenspaces that were fragmented from natural habitats are now overcrowded, while revegetated new greenspaces remain vacant. This is because they have different processes leading towards biodiversity equilibrium, and conservation management needs to differentiate between fragmented and revegetated greenspaces.
Comparison of PsbQ and Psb27 in photosystem II provides insight into their roles

Photosystem II (PSII) catalyzes the oxidation of water at its active site that harbors a high-valent inorganic Mn4CaOx cluster called the oxygen-evolving complex (OEC). Extrinsic subunits generally serve to protect the OEC from reductants and stabilize the structure, but diversity in the extrinsic subunits exists between phototrophs. Recent cryo-electron microscopy experiments have provided new molecular structures of PSII with varied extrinsic subunits. We focus on the extrinsic subunit PsbQ, that binds to the mature PSII complex, and on Psb27, an extrinsic subunit involved in PSII biogenesis. PsbQ and Psb27 share a similar binding site and have a four-helix bundle tertiary structure, suggesting they are related. Here, we use sequence alignments, structural analyses, and binding simulations to compare PsbQ and Psb27 from different organisms. We find no evidence that PsbQ and Psb27 are related despite their similar structures and binding sites. Evolutionary divergence within PsbQ homologs from different lineages is high, probably due to their interactions with other extrinsic subunits that themselves exhibit vast diversity between lineages. This may result in functional variation as exemplified by large differences in their calculated binding energies. Psb27 homologs generally exhibit less divergence, which may be due to stronger evolutionary selection for certain residues that maintain its function during PSII biogenesis and this is consistent with their more similar calculated binding energies between organisms. Previous experimental inconsistencies, low confidence binding simulations, and recent structural data suggest that Psb27 is likely to exhibit flexibility that may be an important characteristic of its activity. The analysis provides insight into the functions and evolution of PsbQ and Psb27, and an unusual example of proteins with similar tertiary structures and binding sites that probably serve different roles.
Advances in nutrient management make it possible to accelerate biogas production and thus improve the economy of food waste processing

Foodwaste (hereinafter, FW) is the most voluminous solid waste and its amount is growing rapidly all over the world. The turning of FW into biogas via anaerobic fermentation is widely recognized as an environmentally responsible and economically reasonable option. Based on the knowledge obtained from agricultural biogas stations, the current methods of FW fermentation management are based on balancing the ratio of total carbon and nitrogen. However, it was repeatedly and independently reported that the stability of this process is low, resulting in many concessions in terms of prolonged hydraulic retention time or reduced biogas yield. Hence, biochemical as well as economic performance of the process is balanced by mixing of FW with agricultural residues. FW samples of various origin were collected and biochemically analyzed. The data indicate that FW originating from homes and luxury restaurants tends to be lignocellulose-based, whereas the levels of crude fiber (25% up to 27%) are higher than those from agricultural feedstock (18%). In contrast, FW from school canteens and inexpensive restaurants tends to be starch-based with high levels of amyloids (21% up to 23%) and fat (5% up to 7%). A novel method better reflecting the bioavailability of carbon and nitrogen to anaerobic consortia is proposed. It is demonstrated that the previous optimization methods could somehow reflect the availability of nutrients in agricultural feedstock, as carbonaceous and nitrogen sources are relatively equally biodegradable. Nevertheless, the biodegradability of FW is considerably different, which is why higher amounts of proteins and lipids lead to increased levels of ammonia and sulfide, resulting in an inhibitory effect on the metabolism of anaerobic consortia. Optimizing the anaerobic fermentation of FW by the new method outperforms the previous technique and makes it possible to process FW more intensively, or, more precisely, with higher profitability and lower proportion of ballast agricultural feedstock.
Shape-stable thermo-responsive nano Fe3O4/fatty acids/PET composite phase-change material for thermal energy management and saving applications

Organic phase change materials are sensitive to temperature calling thermo-responsive materials having ability of thermal energy storage/release in a warm/cold medium through latent heat, indicating proper potential for better thermal energy management. Nonetheless, leakage during melting and undesirable thermal conductivity are considered as two major disadvantages. Herein, for the first time, a simple one-step route is suggested for preparing novel shape-stable nano Fe3O4/fatty acids/PET composite can be utilized in thermal energy saving and management applications. This is based on simultaneous embedment of fatty acids as phase change materials into polyester (PET) fibers as supporting material and formation of iron oxide nanoparticles. The present approach not only obviates two stated drawbacks but also it is free from separately forming or providing nanoparticles and utilizing micro/nano encapsulation or electrospinning which may contain toxic chemicals. It is further conducted in one-single step preferring in the view of both economic and environmental aspects. The composites indicated promising phase temperature intervals of 36.3-54.1 and 26.9-35.5 degrees C for melting and freezing with latent heats of 40.3-59.7 and 40.1-58.2 J/g, respectively. The embedment of iron oxide nanoparticles resulted in thermal conductivity elevation around 44.5-85.8%. The prepared samples displayed good thermal endurance and reliability after 100 thermal treatments. They also had no leakage even after 120 min at 75 degrees C revealed their appropriate leakage-proof property in real usages. Overall, the paper introduces an affordable one-step mode for fabricating shape-stable nano-enhanced composite with proper thermal features for practical thermal energy management and saving applications.
Chromodomain Helicase DNA Binding Protein 1-like, a negative regulator of Forkhead box O3a, promotes the proliferation and migration of Angiotensin II-induced vascular smooth muscle cells

Essential hypertension (EH) represents a major risk factor for stroke, myocardial infarction, and heart failure. Dysregulated proliferation and migration of vascular smooth muscle cells (VSMCs) play an important role in pathogenesis of EH. This study aims to investigate the effect of Chromodomain Helicase DNA Binding Protein 1-Like (CHD1L) on Angiotensin II (AngII)-induced VSMCs injury and reveal the underlying mechanism. The expression of CHD1L in EH patients was determined by bioinformatics analysis, and then it was silenced in AngII-induced VSMCs to detect the changes in cellular functions including proliferation, migration, invasion and phenotypic switching via CCK-8, EDU staining, wound healing, transwell and Western blot assays, respectively. Inflammation and oxidative stress were also measured by detecting related markers via commercial kits. After confirming the binding sites between forkhead box O3A (FOXO3a) and CHD1L and their negative association by bioinformatics analysis, FOXO3a was further silenced, and the cellular functions were assessed again to reveal the underlying mechanism. Results showed that CHD1L was highly expressed in EH, and interference of CHD1L suppressed the proliferation, migration, invasion and phenotypic switching in VSMCs. Inflammation and oxidative stress were also restrained by CHD1L knockdown. After validating the negative role of FOXO3a in regulating CHD1L, it was found that FOXO3a abrogated the effect of CHD1L knockdown on the cellular functions of AngII-induced VSMCs. In conclusion, FOXO3a suppresses the proliferation and migration of AngII-induced VSMCs by down-regulating CHD1L.
Does physical weight alter the mental representation of the body? Evidence from motor imagery in obesity

Obesity is a clinical condition that impacts severely the physical body. However, evidence related to the mental representation of the body in action is scarce. The few available studies only focus on avoiding obstacles, rather than participants imagining their own body. To advance knowledge in this field, we assessed the performance of 22 individuals with obesity compared with 30 individuals with a healthy weight in two tasks that implied different motor (more implicit vs. more explicit) imagery strategies. Two tasks were also administered to control for visual imagery skills, to rule out confounding factors. Moreover, we measured body uneasiness, through a standard questionnaire, as body image negativity could impact on other body representation components. Our findings do not show differences in the motor imagery tasks between individuals with obesity and individuals with healthy weight. On the other hand, some differences emerge in visual imagery skills. Crucially, individuals with obesity did report a higher level of body uneasiness. Despite a negative body image and visual imagery differences, obesity per se does not impact on the representation of the body in action. Importantly, this result is independent from the level of awareness required to access the mental representation of the body.
The environmental sustainability effects of income, labour force, and tourism development in OECD countries

The impacts of the increasing human activities mostly through socio-economic and environment interactions have continued to generate more scientific studies and contemporary discussion on issues ranging from the climate change to income and gender gap. Accordingly, the current study employed the cointegration and a two-step (system) SYS-Generalized Method of Moments to examine the environmental sustainability effects of income, international tourism arrivals, and labour force vis-a-vis gender unemployment in the panel of (32) Organization for Economic Development and Corporation (OECD) for the period 1995-2016. The study revealed that income growth in the OECD countries and increase in the inflow of international tourists into the OECD member countries are significant endangering factors for the bloc's environmental sustainability. More striking is the environmental impact of labour force in the panel countries. Intuitively, a positive labour force-environmental degradation nexus is expected; the negatively desirable labour force-environmental degradation nexus in the current study is a justification of (1) the prevailing gender employment/unemployment classifications in the OECD member countries, and (2) the increasing adoption of more environmental friendlier working conditions or operation among the member countries. Moreover, the current study strongly posits a significant policy framework for the governments and stakeholders of the OECD member countries.
Techno-economic analysis of a grid-connected PV/battery system using the teaching-learning-based optimization algorithm

In this paper, a novel framework for optimal sizing of a grid-connected photovoltaic (PV)/battery system is presented to minimize the total net present cost using a novel optimization algorithm based on the teaching and learning process, namely Teaching-Learning-Based Optimization (TLBO). The TLBO algorithm is an efficient optimization method based on the teacher's influence on the learners' output in a class. This article shows how backup PV/battery systems can reduce electricity bills, even in countries where their electricity is cheap and subsidized. In comparison to the non-renewable case, the net present cost (NPC) and the cost of energy (COE) of the on-grid PV/battery system are 15.6% and 16.8% more efficient, respectively. The NPC and COE factors were calculated and compared with two other popular optimization algorithms, particle swarm optimization, and genetic algorithm to validate the proposed approach and to ascertain the strength and accuracy of the TLBO algorithm. To compare the results, different cities were examined and the similarity of the results showed that the system is efficient regardless of the surrounding climate. Also, sensitivity analyses on different cities' climatic data, different load demands and PV prices outlined the economic optimal size of the system.
Interplay between technological innovation and environmental quality: Formulating the SDG policies for next 11 economies

Since the inception of Sustainable Development Goals (SDGs), the Next 11 (N11) countries are facing difficulties in attaining the SDG objectives, as maintaining the environmental quality has been a challenge for them. In this study, we have revisited the technology policies of these countries, and in doing so, we have tried to address the problem of environmental degradation, while addressing the issues of sustained economic growth, clean and affordable energy, and quality education. In this pursuit, we have designed two indices for environmental degradation and technological advancement, and then analyzed the association between them following the Environmental Kuznets Curve (EKC) hypothesis. The empirical analysis has been done by IPAT framework, and by using bootstrapped quantile regression and rolling window heterogeneous panel casualty tests, over a period of 1990-2017. Following the results obtained from the analysis, we have tried to address the objectives of SDG 13, SDG 4, SDG 8, SDG 9, SDG 7, and SDG 10. (c) 2019 Elsevier Ltd. All rights reserved.
Treatment technologies for bakers' yeast production wastewater

Researchers in recent years have utilized a broad spectrum of treatment technologies in treating bakers' yeast production wastewater. This paper aims to review the treatment technologies for the wastewater, compare the process technologies, discuss recent innovations, and propose future perspectives in the research area. The review observed that nanofiltration was the most effective membrane process for the treatment of the effluent (at >95% pollutant rejection). Other separation processes like adsorption and distillation had technical challenges of desorption, a poor fit for high pollutant load and cost limitations. Chemical treatment processes have varying levels of success but they are expensive and produce toxic sludge. Sludge production would be a hurdle when product recovery and reuse are targeted. It is difficult to make an outright choice of the best process for treating the effluent because each has its merits and demerits and an appropriate choice can be made when all factors are duly considered. The process intensification of the industrial-scale production of the bakers' yeast process will be a very direct approach, where the process optimisation, zero effluent discharge, and enhanced recovery of value-added product from the waste streams are important approaches that need to be taken into account.
Frequency of Thrombotic Risk Factors in Patients with Chronic Thromboembolic Pulmonary Hypertension and Acute Pulmonary Embolism: A Case-Control Study

Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious complication of acute pulmonary embolism (PE) which remains underdiagnosed. A better understanding of risk factors for CTEPH would improve our ability to predict which PE survivors are at risk. Several medical conditions-including malignancy, splenectomy, thyroid hormone supplementation, the presence of an intravascular device, inflammatory bowel disease, osteomyelitis, and non-O blood group-have been associated with increased risk of CTEPH, primarily in studies comparing patients with CTEPH to individuals with non-thrombotic conditions. Because many of these conditions increase thrombosis risk, it remains unclear whether their association with CTEPH reflects a general effect on thrombosis risk, or a specific effect on the risk of developing CTEPH as an outcome of thrombosis. We performed a case-control study comparing the frequencies of these conditions in patients with CTEPH versus patients with acute PE who did not develop CTEPH. The conditions studied were equally frequent in the CTEPH and PE cohorts, although there was a trend towards an increased frequency of splenectomy and non-O blood group among the CTEPH cohort. Thus, other than the possible exceptions of splenectomy and non-O blood group, the investigated medical conditions do not appear likely to increase the risk of CTEPH as an outcome of acute PE, and thus are unlikely to be useful in predicting CTEPH risk among PE survivors.
Pruritus as a Presenting Symptom of FIP1L1-PDGFRA-Positive Chronic Eosinophilic Leukemia

Eosinophilia can be found in a variety of benign and malignant conditions, and a persistent eosinophilic count of more than 1500/mm3 necessitates additional investigation. Patients with FIP1L1-PDGFRA-positive chronic eosinophilic leukemia might present as asymptomatic or in a catastrophic state with multi-organ involvement. We present the case of a young male patient who was diagnosed with FIP1L1-PDGFRA chronic eosinophilic leukemia after a long history of recurrent cutaneous symptoms with no systemic signs.