ahmedabdelwahed/Medical_papers_title_and_abstract_NLP_dataset huggingface dataset:
Factors affecting the travel mode choice of the urban elderly in healthcare activity: comparison between core area and suburban area

This study investigated the travel characteristics and influential factors of travel mode choice for healthcare activity by the elderly in core area and suburb. The results of descriptive analysis and multinomial logistic models show that: (1) Bus and walking are main modes for the elderly to seek medical treatment. The elderly in suburb travel longer distance and are more dependent on bus than those in core area. (2) The service efficiency improvements of hospitals could promote the elderly in core area to choose green modes, while those in suburb are more likely to utilize cars to obtain high-quality medical resources. (3) For long-distance travel, the influence of family economic backgrounds on the mode choice is more significant in suburb, and the difference of family economic will further aggravate the internal differentiation in long-distance travel among the elderly in suburb. (4) Interestingly, the elderly in core area tend to utilize cars to seek for healthcare when they live with their offspring, while those in suburb tend to use cars and taxis when they have serious illness and require companion. Finally, relevant policies and suggestions were proposed to improve the accessibility and fairness of healthcare travel for the elderly.
Prehospital Trauma Airway Management: An NAEMSP Position Statement and Resource Document

Definitive management of trauma is not possible in the out-of-hospital environment. Rapid treatment and transport of trauma casualties to a trauma center are vital to improve survival and outcomes. Prioritization and management of airway, oxygenation, ventilation, protection from gross aspiration, and physiologic optimization must be balanced against timely patient delivery to definitive care. The optimal prehospital airway management strategy for trauma has not been clearly defined; the best choice should be patient-specific. NAEMSP recommends:The approach to airway management and the choice of airway interventions in a trauma patient requires an iterative, individualized assessment that considers patient, clinician, and environmental factors.Optimal trauma airway management should focus on meeting the goals of adequate oxygenation and ventilation rather than on specific interventions. Emergency medical services (EMS) clinicians should perform frequent reassessments to determine if there is a need to escalate from basic to advanced airway interventions.Management of immediately life-threatening injuries should take priority over advanced airway insertion.Drug-assisted airway management should be considered within a comprehensive algorithm incorporating failed airway options and balanced management of pain, agitation, and delirium.EMS medical directors must be highly engaged in assuring clinician competence in trauma airway assessment, management, and interventions.
Digital Transformation and Knowledge Management in the Public Sector

Digitizing public services is, at the moment, an essential necessity for numerous governments around the world. An improved government through digitization will not only have a growing effect on businesses, but it will also be able to intensify citizen engagement and push for economic growth. During the last 10 years more countries have progressively begun to provide digital services to their citizens. Therefore, in order to address this development, the purpose of this paper is to analyze the evolution of the digital government literature in order to describe the aspects of digital transformation in the public sector and how it is related to knowledge management. In this study the methodology is quantitative and it is based on a review and a survey made with the main goal being the estimation from several collected data on how the digital transformation process in the Public Administration takes place and what its relationship is with knowledge management. The review study is based on articles found on Scopus database and it addresses the role that digital government research plays in the theory and practice of knowledge management. In the survey study, 54 employees working for the services of the two governmental areas of the Portuguese Ministry of the Environment were surveyed. The results show that the research on the theme is still at an exploratory stage due to the lack of studies relating digital government to knowledge management effectiveness in the public sector. The results also show that the success of digital government seems to be related with the quality of the organizations' knowledge management, complementing each other for significant improvements in the public sector. In terms of originality, this study aims to contribute and stimulate data-driven discussions regarding the impacts of the digital transformation in the public sector and their relation with the implementation of knowledge management practices. The results offer insights into future research needs.
The nexus between renewable energy, economic growth, trade, urbanisation and environmental quality: A comparative study for Australia and Canada

Using a comparative approach, this study examines the nexus among renewable energy consumption, economic growth, trade, urbanisation and CO2 emissions for Australia and Canada for the period 1960-2015. The Autoregressive Distributed Lag (ARDL) bounds tests are used to explore the long-run relationships amongst the selected variables and the causal relationships are examined by the vector error correction model (VECM) Granger causality tests. The findings suggest that there is evidence of the long run relationships amongst the variables. The results in Australia indicate that in both the long run and short run, economic growth increases CO2 emissions, whereas in the short run, the trade and renewable energy consumptions decrease CO2 emissions. The VECM causality tests for Australia indicate that in the short-run, the economic growth, trade, and renewable energy consumption Granger cause CO2 emissions; whereas the long-run causal relationships are found among CO2 emissions, economic growth, trade and renewable energy consumption. In the case of Canada, the results show that in both the long run and short run, trade increases CO2 emissions, while in the long run the economic growth and urban population increase CO2 emissions. The VECM causality analyses show the long-run bidirectional causality among CO2 emissions, economic growth, and renewable energy consumption. In addition, the CO2 emissions tended to decrease in Australia but not in Canada after each country officially ratified the Kyoto Protocol in 2007 and 2002, respectively. Policy recommendations are made based on these findings. (C) 2020 Elsevier Ltd. All rights reserved.
When breaks get hot: inflammatory signaling in BRCA1/2-mutant cancers

Genomic instability and inflammation are intricately connected hallmark features of cancer. DNA repair defects due to BRCA1/2 mutation instigate immune signaling through the cGAS/STING pathway. The subsequent inflammatory signaling provides both tumor-suppressive as well as tumor-promoting traits. To prevent clearance by the immune system, genomically instable cancer cells need to adapt to escape immune surveillance. Currently, it is unclear how genomically unstable cancers, including BRCA1/2-mutant tumors, are rewired to escape immune clearance. Here, we summarize the mechanisms by which genomic instability triggers inflammatory signaling and describe adaptive mechanisms by which cancer cells can 'fly under the radar' of the immune system. Additionally, we discuss how therapeutic activation of the immune system may improve treatment of genomically instable cancers.
Convergence analysis of city-level energy intensity in China

Understanding the convergence patterns of energy intensity and the drivers leading to the club convergence are of great significance for local governments to implement targeted policies to improve energy efficiency. With this in mind, we begin with the collection of energy consumption data of 193 Chinese cities at prefecture level or above, then we adopt the log t-test and clustering algorithm to investigate convergence characteristics of energy intensity. Besides, the Ordered Probit model is adopted to investigate the drivers that affect the formulation of convergent club. We identify four convergent clubs among total 193 cities, and these clubs show great differences in energy intensity. Marketization degree, population density, foreign direct investment, resource endowment, and industrial structure are recognized as the drivers of the formation of convergence clubs. This paper adds more evidence to understand the energy intensity gap, we propose that upgrading the industrial structure, exerting economic assemble advantage, enhancing the level of opening up, and improving the marketization level are favorable measures to reduce energy intensity.
Adapting to the COVID-19 pandemic: A survey of UK and European hand surgery units

Hand surgery services had to rapidly adapt to the coronavirus disease 2019 (COVID-19) pandemic. The aim of the Reconstructive Surgery Trials Network #RSTNCOVID Hand Surgery survey was to document the changes made in the UK and Europe and consider which might persist. A survey developed by the Reconstructive Surgery Trials Network, in association with the British Association of Hand Therapists, was distributed to hand surgery units across the UK and Europe after the first wave of COVID-19. It was completed by one consultant hand surgeon at each of the 44 units that responded. Adult and paediatric trauma were maintained but elective services stopped. Consultations were increasingly virtual, and surgery was more likely to be under local anaesthetic and in a lower resource setting. Many of the changes are viewed as being beneficial. However, it is important to establish that they are clinically and cost effective. These survey results will help prioritise and support future research initiatives.
Current understandings and perspectives of petroleum hydrocarbons in Alzheimer's disease and Parkinson's disease: a global concern

Over the last few decades, the global prevalence of neurodevelopmental and neurodegenerative illnesses has risen rapidly. Although the aetiology remains unclear, evidence is mounting that exposure to persistent hydrocarbon pollutants is a substantial risk factor, predisposing a person to neurological diseases later in life. Epidemiological studies correlate environmental hydrocarbon exposure to brain disorders including neuropathies, cognitive, motor and sensory impairments; neurodevelopmental disorders like autism spectrum disorder (ASD); and neurodegenerative disorders like Alzheimer's disease (AD) and Parkinson's disease (PD). Particulate matter, benzene, toluene, ethylbenzene, xylenes, polycyclic aromatic hydrocarbons and endocrine-disrupting chemicals have all been linked to neurodevelopmental problems in all class of people. There is mounting evidence that supports the prevalence of petroleum hydrocarbon becoming neurotoxic and being involved in the pathogenesis of AD and PD. More study is needed to fully comprehend the scope of these problems in the context of unconventional oil and natural gas. This review summarises in vitro, animal and epidemiological research on the genesis of neurodegenerative disorders, highlighting evidence that supports inexorable role of hazardous hydrocarbon exposure in the pathophysiology of AD and PD. In this review, we offer a summary of the existing evidence gathered through a Medline literature search of systematic reviews and meta-analyses of the most important epidemiological studies published so far.
Effect of Unsymmetrical Dimethylhydrazine on Isolated Heart and Lymphatic Vessels

Unsymmetrical dimethylhydrazine (UDMH, heptyl) and its derivatives are used in the rocket and space industry as components of rocket fuel. UDMH is a highly toxic compound exhibiting irritant, hepatotoxic, and neurotoxic properties. In this study, the toxic effect of heptyl on isolated rat heart and lymphatic vessels was demonstrated. Acute exposure to UDMH leads to vasoconstriction of the coronary vessels of the isolated heart and pronounced stimulation of isolated lymphangions starting from the concentration of 10-4 M. The changes are dose-dependent. After exposure to UDMH in high concentrations (10-2 M), the changes in the functional parameters became irreversible. The obtained results provide evidence for the organ-specific effect of UDMH on visceral muscle organs.
Linking Information Communication Technology, trade globalization index, and CO(2)emissions: evidence from advanced panel techniques

Previous studies consider ICT a two-edged sword that can harm or benefit the environment. In recent years, ICT penetration has considerably increased in the ASEAN-6 countries and the leaders of ASEAN are willing to bring a digital revolution by increasing ICT infrastructure and reducing trade barriers in the region under the Master Plan of ASEAN Connectivity-2025. Hence, this paper explores the effect of ICT and the recently developed trade globalization index on CO(2)emissions in ASEAN-6 countries. The study relies on advanced panel econometric approaches, including Westerlund (2007,2008) and Pedroni cointegration tests, CUP-FM long-run method, and panel DH causality approach. The results suggest cointegration among variables. The results of CUP-FM indicate that ICT contributes to improving environmental quality by mitigating CO(2)emissions. Similarly, trade globalization is also sustainable in the region as it reduces emissions. The results are also confirmed by using the CUP-BC estimator. The findings from the DH causality test unfold causality from ICT and trade globalization index to CO(2)emissions. Besides, the long-run estimates reveal the detrimental effect of energy consumption on emissions and the U-shaped association between GDP and emissions. Moreover, unidirectional causality from ICT to trade globalization index and energy consumption indicates that ICT influences trade globalization and energy consumption. Finally, environmental policies in the context of ASEAN are extensively discussed.
Epigenetic Modifications and Neurodegenerative Disorders: A Biochemical Perspective

Methylations in living cells are methyl groups attached to amino acids, DNA, RNA, and so on. However, their biochemical roles have not been fully defined. A theory has been postulated that methylation leads to hyperconjugation, and the electron-donating feature weakens a nearby chemical bond, which increases the bond length of C4-N4 of 5-methylcytosine, therefore weakening the C4-N4 bond and resulting in stronger protonation or hydrogen bonding of the N4 nitrogen atom. Protonation can give rise to the generation of mutagenic and carcinogenic strong acids such as HCl, which are also capable of solubilizing stressful, insoluble, and stiff salts. Insoluble and rigid salts such as calcium oxalate and/or calcium phosphate were recently proposed as a primary cause of some neurodegenerative disorders. Protonation of nitrogen atoms in 5-methylcytosine enhances the interaction with negatively charged phosphate groups and contributes to the formation of compact heterochromatin. The electronegativity of the oxygen atoms in the modifications of 5-hydroxymethylcytosine or 5-formylcytosine can shorten the lengths of adjacent bonds with no increase of cation affinity in N4. The carboxyl group in 5-carboxylcytosine is a weak acid capable of antagonizing mutagenic HCl and modestly helping solubilize insoluble salts. Electron delocalization of the methyl group in N4-methylcytosine results in a lower affinity of N4 to cations. The positive charge at N3 in the resonance structure of 3-methylcytosine is lessened by the electron-donating attribute of the methyl group attached to the N3 atom, consequently reducing acid formation. The electron delocalization of three methyl groups decreases the positive charge in the amino nitrogen in the side group of lysine 4 in histone H3, weakening interactions with phosphate groups and consequently activating gene expression. The carbonyl oxygen in 8-oxo-7,8-dihydroguanine draws protons and accumulates HCl, accounting for its moderate mutation propensity and potential capacity to solubilize stiff salts. The biochemical insight will further our understanding on the crosstalk of genetics and epigenetics in the etiology of neurodegenerative diseases.
Pyroptosis regulators exert crucial functions in prognosis, progression and immune microenvironment of pancreatic adenocarcinoma: a bioinformatic and in vitro research

Pyroptosis is an inflammatory programmed cell death, showing potentials to be a novel anti-cancer approach. However, the roles of pyroptosis-related (PR) genes (PRGs) in pancreatic adenocarcinoma (PAAD) remain elusive. In the present study, we constructed a novel PR risk signature through the lasso regression analysis. The risk signature was greatly conducive to PAAD prognostic assessment. PR risk score was identified as an independent prognostic factor and could distinguish the prognostic differences of most clinical subgroups. Meanwhile, it could improve the traditional prognostic models based on TNM-staging. Next, its prognostic value was also tested in five validation cohorts. Using CIBERSORT, ESTIMATE, and ssGSEA algorithms, the effects of PR risk signature on tumor immune microenvironment (TIM) were explored. High PR risk suppressed antitumor immune through decreasing the infiltrating levels of CD8 T and NK cells. The genomic information and histological expression of risk PRGs were uncovered by USCA and HPA databases. Somatic mutation, methylation alteration, and homozygous CNV of eight PRGs barely occurred in PAAD samples. As for therapeutic correlation, PR risk score may not predict the efficacy of PD-1/L1 inhibitors and was weakly associated with multiple drug susceptibilities. Finally, the biofunctions of toll like receptor 3 (TLR3) in pancreatic cancer (PC) cells were investigated through qPCR, MTT, colony formation, and Transwell assays. Overexpression of TLR3 could promote the proliferation, migration, and invasion of PC cells. In conclusion, PRGs play crucial roles in prognosis, progression, and immune microenvironment of PAAD. TLR3 is expected to be a promising therapeutic target.
Emergy-based ecosystem services valuation and classification management applied to China's grasslands

Though grasslands cover one fifth area of global land and provide vital services for humans, half of them are degraded due to human interference and climate change. In this paper we perform evaluations of the delivery of ecosystem services (ES) of grasslands using a systems approach and the technique of emergy accounting. Firstly, we address the issue of anthropocentricity of ES through discussion and analysis using the concept of emergy as contrasted to economic value, i.e. willingness-to-pay. Secondly, we explore from a systems classification of provisioning, regulating, cultural and supporting services. Thirdly, we provide quantitative analysis of the value added (surplus value) to economies by ecosystems. An emergy-based index of classification management of grassland (ICG), is also implemented, together with a non-monetary benefit-cost analysis of grassland ES. It is established that emergy provides an approach to evaluating the contributions ecosystems make to the economy using the idea of net benefit ratio, computed as the emergy cost of providing a service through technology (aka replacement cost) divided by emergy required to sustain ecosystem functions. This study can provide a systematic biophysical accounting method for grassland ESV to implement future sustainable management practices.
Prehospital Airway Management Training and Education: An NAEMSP Position Statement and Resource Document

AbstractAirway management competency extends beyond technical skills to encompass a comprehensive approach to optimize patient outcomes. Initial and continuing education for airway management must therefore extend beyond a narrow focus on psychomotor skills and task completion to include appreciation of underlying pathophysiology, clinical judgment, and higher-order decision making. NAEMSP recommends:Active engagement in deliberate practice should be the guiding approach for developing and maintaining competence in airway management.EMS learners and clinicians must be educated in an escalating approach to airway management, where basic airway maneuvers form the central focus.Educational activities should extend beyond fundamental knowledge to focus on the development of clinical judgment.Optimization of patient outcomes should be valued over performance of individual airway management skills.Credentialing and continuing education activities in airway management are essential to advance clinicians beyond entry-level competency.Initial and continuing education programs should be responsive to advances in the evidence base and maintain adaptability to re-assess content and expected outcomes on a continual basis.
Impact of financial development and energy consumption on environmental degradation in 184 countries using a dynamic panel model

This study aimed to examine the impact of financial development and energy consumption on CO2 emissions by employing balanced panel data from the period 1990-2017 for 184 countries worldwide. This study applied seemingly unrelated regression (SUR), two-step difference, and the system GMM model for data analysis. The examined results of SUR, two-step difference, and system GMM show that energy consumption positively impacts the CO2 emissions worldwide; on the other hand, the examined results of two-step difference and the system GMM model indicate that financial development helps to reduce the CO2 emissions and the results of SUR indicate that financial development positively impacts the CO2 emissions. The examined results regarding economic growth indicate a positive effect on the CO2 emission and the square of economic growth verifies the validly of the environmental Kuznets curve in 184 countries. This study has significant implications for policy makers with regard to environment improvement, clean energy conservation, and an efficient financial system. Further directions are suggested based on the examined results.
Residential energy environmental Kuznets curve in emerging economies: the role of economic growth, renewable energy consumption, and financial development

The aim of the present paper is to determine residential energy environmental Kuznets curve (EKC) in Next-11 and BRICS countries with the specific consideration on the role of economic growth, renewable energy consumption, and financial development from an era of 1990-2015. In order to determine the cross-section independence and to control the heterogeneity between cross-sections in the paper, we have applied unique and advanced techniques of econometrics panel data. Moreover, the following tests have been applied which are the CIPS unit root test, co-integration test, fully modified ordinary least square (FMOLS), and heterogeneous panel causality technique. The outcomes revealed that in the long run, all the variables are co-integrated. Moreover, there is a significant and positive influence of residential energy consumption, economic growth, and financial development on environmental degradation. However, in the reduction of carbon dioxide (CO2) emissions, essential role is performed by renewable energy. On the other hand, findings show great support for the residential energy EKC hypothesis in emerging countries.