ahmedabdelwahed/Medical_papers_title_and_abstract_NLP_dataset huggingface dataset:
Reliability and validity of the polish version of the vulnerability to Abuse Screening Scale (VASS)

Our aim was to assess the psychometric properties and reliability of a Polish version of the VASS. This cross-sectional validation study involved 228 patients above 65 years of age. Authors-Designed Questionnaire, the Geriatric Depression Scale, and the Activities of Daily Living Scale were used to assess construct validity. Psychometric properties, reliability and repeatability were assessed. Cronbach's alpha coefficient for the VASS scale was 0.89. Almost all items showed a high correlation value in relation to the others (R > 0.45). A high coefficient of repeatability and narrow limits of agreement were observed in the Bland-Altman analysis. All items analyzed had excellent intraclass correlation coefficient (ICC>0.9) and weighted kappa (κ > 0.9) scores. Very strong, significant correlations with other tools confirm the accuracy of the VASS scale. Our research shows promising validity and reliability Polish version of the VASS scale to assess the risk of elder abuse and neglect.
Numerical analysis of photovoltaic solar panel cooling by a flat plate closed-loop pulsating heat pipe

Photovoltaic (PV) panels provide a suitable way for the direct conversion of solar energy into electricity. The electrical output and efficiency of PV modules are dependent on working temperature. The present study contributes to investigate the efficiency of utilizing a flat plate closed-loop pulsating heat pipe (CLPHP) to cool down a PV panel in both thermal and economic aspects. Accordingly, a numerical investigation is employed to obtain the surface temperature and electrical gain of the PV panel through four scenarios, including natural cooling without additional equipment, CLPHP-based passive cooling, CLPHP-based active cooling, and a conventional flat plate cooling methods. The efficiency of the cooling approaches is investigated in three different solar radiations and ambient temperatures according to the climatic condition of the considered location, Kerman, Iran. The improvement rate function is established to elaborate on the electrical gain efficiency of each scenario. Furthermore, each scenario is economically compared in terms of the payback period of the different cooling approaches. It is concluded that applying CLPHP-based passive, and active cooling approaches increase the improvement rate by 23% and 35% at the solar radiation of 1235 W/m(2), respectively. In addition, the results demonstrated that while the 4th scenario, conventional approach, induces higher improvement rate, it requires more operational cost, so increases the payback period by about 10% compared to the 3rd scenario. Accordingly, it is concluded that utilizing CLPHP for cooling the PV panel is an appropriate and cost-effective approach to increase the efficiency of the PV panel.
Quantitative structure-activity relationship(QSAR) models for color and COD removal for some dyes subjected to electrochemical oxidation

Electrochemical oxidation is an efficient method for the destruction of dyes in wastewater streams. The experimental conditions during electrochemical oxidation (EO) and molecular structure of a dye greatly influence the extent of degradation. The extent of degradation for a variety of dyes by EO can be predicted conveniently by the use of Quantitative structure-activity Relationship (QSAR) models. An abundant amount of published data on dye degradation by EO using highly variable experimental conditions lies unutilized to prepare QSAR models. In this study, an effort is made to use published experimental data on EO of aqueous dyes after applying an easy method of normalization, to prepare QSAR models for percent color and COD removal. Normalized color and COD removal were obtained by multiplying the reported removal by volume of reactor and concentration of dye; and divided by total current passed and the time of electrolysis. More than 15 molecular descriptors were computed using Schrodinger-suit 2018-3. The multiple linear regression (MLR) approach was used to develop normalized color and COD removal models. The quantum chemical descriptors: highest occupied molecular orbital energy (HOMO) and lowest unoccupied molecular orbital energy (LUMO), polar surface area (PSA), hydrogen bond donor count (HBD), and number of atoms were found significant. The statistical indices: goodness-of-fit, R2 > 0.75, and internal and external validations, Q2LOOCV and Q2ext, > 0.5, satisfied the criteria for predictive models and indicated that the method of normalization used in this study is adequate. Developed QSAR models are quite simple, interpretable, and transparent.
Techno-economic assessment of biomass gasification-based mini-grids for productive energy applications: The case of rural India

As the costs of solar PV continuously decrease and pollution legislation imposes less burning of agricultural residues, decentralized renewable energy is increasingly affordable for providing electricity to one billion people lacking access to a power grid. This paper presents a techno-economic feasibility case study of biomass gasification in off-grid and grid-connected mini-grids for community-scale energy application in rural Uttar Pradesh, India. Energy demand data was collected through surveys in a village with irrigation and agro-processing loads and off-grid households and used to construct a seasonal load profile based on statistical methods. This was used to simulate single-source and hybrid mini-grids based on solar PV, biomass gasification and diesel generation using HOMER Pro. Hybrid PV-biomass or PV-diesel systems were found to offer the highest reliability for off-grid power at the lowest cost. Single-source PV was cheaper than biomass gasification, though the cost of electricity is highly sensitive to biomass supply and gasifier maintenance. Both renewable options were around half the cost of diesel generation. The findings held across grid-connected systems with weak, moderate and strong reliability of grid supply. This suggests that biomass gasification-based mini-grids are not cost-competitive with PV unless the two generation sources are combined in a hybrid system, though they require operational testing prior to implementation. (C) 2020 Elsevier Ltd. All rights reserved.
Linking biomass energy and CO2 emissions in China using dynamic Autoregressive-Distributed Lag simulations

Can biomass energy mitigate CO2 emissions in China? Given increasing environmental pollution and global warming, countries are switching to alternate energy sources that might help pollution reduction and mitigate climate change. In this scenario, biomass energy has received the attention of academic scholars and policy analyst alike. What role biomass energy can play in environmental pollution remains uncertain, so further investigation is necessary. To this end, this study explores the relationships of biomass energy and real income with CO2 emissions for China. Empirical evidence is based on the use of Jordan and Philips' (2018) econometric tool, dynamic Autoregressive-Distributed Lag (DARDL) simulations, on data from 1982 to 2017. The results reveal a negative relationship between China's biomass energy consumption and CO2 emissions, suggesting that biomass energy consumption is helpful in reducing pollution. Likewise, biomass energy production reduces carbon emissions and might be the best alternative to fossil fuels. Useful policy implications can be drawn related to biomass energy, especially in attaining sustainable development goals. (C) 2019 Elsevier Ltd. All rights reserved.
Economic and environmental life cycle assessment of organic waste treatment by means of incineration and biogasi fication. Is source segregation of biowaste justi fied in Germany?

In the realm of the German scope, four different waste treatment options for the Organic Fraction of Municipal Solid Waste (OFMSW) were evaluated against the environmental and economic background: (i) anaerobic digestion followed by composting, (ii) incineration of OFMSW, (iii) incineration of separately pre-dried OFMSW and (iv) a cascaded treatment system, which couples anaerobic digestion with incineration (i.e. incineration of digestate). Environmental life cycle assessment (eLCA) and a calculation of the levelized costs of exergy (LCOE) were performed to map the sustainability aspects of the different product systems. Within a hybrid approach, consisting of literature data evaluation, theoretical modelling, the conduct of lab-scaled experiments and a substrate analysis, a comprehensive assessment was compiled. Within the eLCA, the main drivers of the total environmental impact were the categories global warming potential (GWP) and the fossil depletion potential (FDP). (i) Anaerobic digestion followed by composting and (ii) incineration were hereby characterized by the fewest environmental impacts. With regards to the base case, the GWP was calculated to similar to 500 g CO2-Eq/kWh exergy for these options. The FDP was <0.05 kg oil-Eq/kWh exergy for anaerobic digestion and -0.075 kg oil-Eq/kWh exergy for incineration. The other examined treatment options were characterized by a significantly higher GWP and FDP. The economic assessment showed median LCOE of 27 ct/kWh exergy for anaerobic digestion followed by composting and thus outcompeted incineration (median: 55 ct/kWh Exergy). Separate pre-drying prior to incineration increased the economic burdens marginally. Anaerobic digestion followed by incineration showed the highest economic expenses (89 ct/kWh exergy). In conclusion, anaerobic digestion followed by composting was marked by an overall preferential environmental and economic constellation and source segregation is thereof justified and should further be maintained. (C) 2020 Elsevier B.V. All rights reserved.
Multiple large cell neuroendocrine carcinomas in the rectum and descending colon presented with liver metastasis: A case report

Colorectal large cell neuroendocrine carcinoma (LCNEC) is rare and multiple LCNECs have not been previously reported. We encountered a case of multiple LCNECs in the rectum and the descending colon. A 66-year-old man presented with anal pain. Colonoscopy showed an ulcerated infiltrating tumor in the rectum, and 0.5 cm of erosion in the descending colon. A biopsy revealed LCNEC in both regions. Abdominal computed tomography revealed irregularly enhanced wall thickening at the rectum and hepatic metastases. Due to the diagnosis of LCNEC, laparoscopic abdominoperineal resection of the rectum was performed. Histopathological examination showed a poorly differentiated, LCNEC in both regions. Immunohistochemical examination demonstrated that the tumor cells were positive for chromogranin and synaptophysin. LCNEC was confirmed, and systemic chemotherapy with cisplatin/irinotecan was initiated. To our knowledge, this is the first case report that describes multiple LCNECs in the rectum and descending colon.
Acid-base effects of combined renal deletion of NBCe1-A and NBCe1-B

The molecular mechanisms regulating ammonia metabolism are fundamental to acid-base homeostasis. Deletion of the A splice variant of Na+-bicarbonate cotransporter, electrogenic, isoform 1 (NBCe1-A) partially blocks the effect of acidosis to increase urinary ammonia excretion, and this appears to involve the dysregulated expression of ammoniagenic enzymes in the proximal tubule (PT) in the cortex but not in the outer medulla (OM). A second NBCe1 splice variant, NBCe1-B, is present throughout the PT, including the OM, where NBCe1-A is not present. The purpose of the present study was to determine the effect of combined renal deletion of NBCe1-A and NBCe1-B on systemic and PT ammonia metabolism. We generated NBCe1-A/B deletion using Cre-loxP techniques and used Cre-negative mice as controls. As renal NBCe1-A and NBCe1-B expression is limited to the PT, Cre-positive mice had PT NBCe1-A/B deletion [PT-NBCe1-A/B knockout (KO)]. Although on a basal diet, PT-NBCe1-A/B KO mice had severe metabolic acidosis, yet urinary ammonia excretion was not changed significantly. PT-NBCe1-A/B KO decreased the expression of phosphate-dependent glutaminase and phosphoenolpyruvate carboxykinase and increased the expression of glutamine synthetase, an ammonia-recycling enzyme, in PTs in both the cortex and OM. Exogenous acid loading increased ammonia excretion in control mice, but PT-NBCe1-A/B KO prevented any increase. PT-NBCe1-A/B KO significantly blunted acid loading-induced changes in phosphate-dependent glutaminase, phosphoenolpyruvate carboxykinase, and glutamine synthetase expression in PTs in both the cortex and OM. We conclude that NBCe1-B, at least in the presence of NBCe1-A deletion, contributes to PT ammonia metabolism in the OM and thereby to systemic acid-base regulation.NEW & NOTEWORTHY The results of the present study show that combined deletion of both A and B splice variants of electrogenic Na+-bicarbonate cotransporter 1 from the proximal tubule impairs acid-base homeostasis and completely blocks changes in ammonia excretion in response to acidosis, indicating that both proteins are critical to acid-base homeostasis.
Role of Inflammatory Niche and Adult Cardiomyocyte Coculture on Differentiation, Matrix Synthesis, and Secretome Release by Human Bone Marrow Mesenchymal Stem Cells

Myocardial infarction (MI) causes cardiomyocyte death, provokes innate immune response, and initiates tissue remodeling. The intrinsic healing process is insufficient to replace the lost cells, or regenerate and restore the functional features of the native myocardium. Autologous bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation is being explored to offer therapeutic potential after MI. Here, we cultured human BM-MSC spheroids in three-dimensional collagenous gels for 28 days under exposure to tumor necrosis factor-alpha (+ TNFα), and coculture with adult human cardiomyocytes, or with conditioned media (CM) pooled from TNFα-stimulated adult cardiomyocytes. MSC differentiation marker (CD90, GATA4, cTnI, cTnT, Cx43, MHC, α-actin) expression, matrix protein (elastin, hyaluonic acid, sulfated glycosaminoglycans, laminin, fibrillin, nitric oxide synthase) synthesis, and secretome (cytokines, chemokines, growth factors) release at days 12 and 28 were assessed. MSC density decreased with duration in all culture conditions, except in controls. GATA4 expression was higher in cocultures but lower in + TNFα cultures. Synthesis and deposition of various extracellular matrix proteins and lysyl oxidase within MSC cultures, as well as secretome composition, were strongly dependent on the culture condition and duration. Results suggest that TNFα-induced inflammation suppresses BM-MSC survival and differentiation into mature cardiomyocytes by day 28, while promoting matrix protein synthesis and cytokine release conducive to MI remodeling. These findings could have implications in developing tissue engienering and cell transplantation strategies targeting MI, as well as to develop therapuetics to target inflammation-induced matrix remodeling post-MI.
Antithrombotic Activity of the Antiplatelet Agent Angipur on the Model of Arterial Thrombosis in Rats with Isoproterenol-Induced Myocardial Infarction

We studied the effect of Angipur on the process of experimental thrombosis induced by damage to the carotid artery wall by surface application of 50% ferric chloride (III) solution in rats without comorbidities and with isoproterenol-induced myocardial infarction. In animals without comorbidities, Angipur administered intravenously was 1.2 times less effective, in terms of ED50, than the well-known inhibitor of GPIIb/IIIa platelet receptors tirofiban. However, under conditions of non-coronary myocardial infarction, Angipur significantly prolonged the time of thrombus formation and exhibited 1.4-fold higher activity than the reference drug tirofiban.
Drought Risk to Agricultural Systems in Zimbabwe: A Spatial Analysis of Hazard, Exposure, and Vulnerability

The devastating impacts of drought are fast becoming a global concern. Zimbabwe is among the countries more severely affected, where drought impacts have led to water shortages, declining yields, and periods of food insecurity, accompanied by economic downturns. In particular, the country's agricultural sector, mostly comprised of smallholder rainfed systems, is at great risk of drought. In this study, a multimethod approach is applied, including a remote sensing-based analysis of vegetation health data from 1989-2019 to assess the drought hazard, as well as a spatial analysis combined with expert consultations to determine drought vulnerability and exposure of agricultural systems. The results show that droughts frequently occur with changing patterns across Zimbabwe. Every district has been affected by drought during the past thirty years, with varying levels of severity and frequency. Severe drought episodes have been observed in 1991-1992, 1994-1995, 2002-2003, 2015-2016, and 2018-2019. Drought vulnerability and exposure vary substantially in the country, with the south-western provinces of Matabeleland North and South showing particularly high levels. Assessments of high-risk areas, combined with an analysis of the drivers of risk, set the path towards tailor-made adaptation strategies that consider drought frequency and severity, exposure, and vulnerability.
Urban Digital Twins for Smart Cities and Citizens: The Case Study of Herrenberg, Germany

Cities are complex systems connected to economic, ecological, and demographic conditions and change. They are also characterized by diverging perceptions and interests of citizens and stakeholders. Thus, in the arena of urban planning, we are in need of approaches that are able to cope not only with urban complexity but also allow for participatory and collaborative processes to empower citizens. This to create democratic cities. Connected to the field of smart cities and citizens, we present in this paper, the prototype of an urban digital twin for the 30,000-people town of Herrenberg in Germany. Urban digital twins are sophisticated data models allowing for collaborative processes. The herein presented prototype comprises (1) a 3D model of the built environment, (2) a street network model using the theory and method of space syntax, (3) an urban mobility simulation, (4) a wind flow simulation, and (5) a number of empirical quantitative and qualitative data using volunteered geographic information (VGI). In addition, the urban digital twin was implemented in a visualization platform for virtual reality and was presented to the general public during diverse public participatory processes, as well as in the framework of the "Morgenstadt Werkstatt" (Tomorrow's Cities Workshop). The results of a survey indicated that this method and technology could significantly aid in participatory and collaborative processes. Further understanding of how urban digital twins support urban planners, urban designers, and the general public as a collaboration and communication tool and for decision support allows us to be more intentional when creating smart cities and sustainable cities with the help of digital twins. We conclude the paper with a discussion of the presented results and further research directions.
Classification and Radiological Diagnosis of Thoracolumbar Spine Fractures: WFNS Spine Committee Recommendations

The aim of this review to determine recommendations for classification and radiological diagnosis of thoracolumbar spine fractures. Recommendation was made through a literature review of the last 10 years. The statements created by the authors were discussed and voted on during 2 consensus meetings organized by the WFNS (World Federation Neurosurgical Societies) Spine Committee. The literature review was yielded 256 abstracts, of which 32 were chosen for full-text analysis. Thirteen papers evaluated the reliability of a classification system by our expert members and were also chosen in this guideline analysis. This literature review-based recommendation provides the classification and radiologic diagnosis in thoracolumbar spine fractures that can elucidate the management decision-making in clinical practice.
Elaboration of geopolymers based on clays by-products from phosphate mines for construction applications

Yellow clays from Moroccan phosphate mines are extracted with other waste rocks lithologies and stored in large dumps within the mine site. The present paper investigates the use of this by-product as a new aluminosilicate source for geopolymers elaboration at the laboratory scale. Yellow clays studied are mainly composed of montmorillonite, dolomite and quartz as major phases. The Toxicity Characteristic Leaching Procedure (TCLP) showed no existence of contaminant. In order to reach thermal activation, the raw clays were first calcined at different temperatures between 500 and 900 degrees C. Raw and calcined clays were characterized using thermogravimetric analysis (TGA), X-Ray Diffraction (XRD) and Fourier transformed infrared (FTIR) spectroscopy. For the synthesis of geopolymers, calcined powder was mixed with an alkaline solution presenting different NaOH/Na2SiO3 ratios. The compressive strength was measured at 7, 14 and 28 days and material porosity was determined using Mercury Intrusion Porosimetry method in order to explain the mechanical behavior. XRD, 27Al and 29Si Magic Angle Spinning Nuclear Magnetic Resonance (MAS-NMR) spectroscopy, Fourier transformed infrared and TGA have been used to investigate the gel structure. The thermal treatment at 900 degrees C allowed the destruction of crystalline structure of montmorillonite clays, as well as the formation of new phases such as periclase (MgO) and gehlenite (Ca2Al2SiO7). Furthermore, the Al-27 - Si-29 MAS-NMR and the XRD analysis of the elaborated materials confirmed the formation of two cementitious gels C-A-S-H (Calcium aluminum silicate hydrate) and N-A-S-H (Sodium aluminum silicate hydrate). The compressive strength was around 25 MPa at 28 days. The obtained results are promising; they have shown that elaborated materials can be adapted for construction applications. In this case, it is recommended that economic and commercial study be developed. (C) 2020 Elsevier Ltd. All rights reserved.
Clinical impact of subcutaneous treprostinil in trisomy 21 patient with pulmonary arterial hypertension associated with CHD

Subcutaneous treprostinil is commonly used to improve idiopathic pulmonary arterial hypertension in children. However, its effectiveness has not been reported in trisomy 21. We report the case of 9-year-old boy in trisomy 21 with CHD-pulmonary artery hypertension after surgical correction of CHD. Haemodynamics and exercise capacity dramatically improved with a transition from oral selexipag to subcutaneous treprostinil.
Pollution, economic growth, and COVID-19 deaths in India: a machine learning evidence

This study uses two different approaches to explore the relationship between pollution emissions, economic growth, and COVID-19 deaths in India. Using a time series approach and annual data for the years from 1980 to 2018, stationarity and Toda-Yamamoto causality tests were performed. The results highlight unidirectional causality between economic growth and pollution. Then, a D2C algorithm on proportion-based causality is applied, implementing the Oryx 2.0.8 protocol in Apache. The underlying hypothesis is that a predetermined pollution concentration, caused by economic growth, could foster COVID-19 by making the respiratory system more susceptible to infection. We use data (from January 29 to May 18, 2020) on confirmed deaths (total and daily) and air pollution concentration levels for 25 major Indian cities. We verify a ML causal link between PM2.5, CO2, NO2, and COVID-19 deaths. The implications require careful policy design.