ahmedabdelwahed/Medical_papers_title_and_abstract_NLP_dataset huggingface dataset:
Comparative Informativity of Computing Methods of Insulin Resistance Assessment

We conducted a comparative study of the calculated indices of insulin resistance HOMA-R, Caro, FGIR, and QUICKI in 29 healthy volunteers (mean age 26.21±0.93 years) with normal body mass index (23.34±0.55 kg/m2). Among the used methods for insulin resistance assessment, QUICKI is the only method that has characteristics required for the diagnostic criterium: low variability coefficient, 100% reproducibility, and minimum coefficient of variation.
KV7.1 channel blockade inhibits neonatal renal autoregulation triggered by a step decrease in arterial pressure

KV7 channels, the voltage-gated K+ channels encoded by KCNQ genes, mediate heterogeneous vascular responses in rodents. Postnatal changes in the functional expression of KV7 channels have been reported in rodent saphenous arteries, but their physiological function in the neonatal renal vascular bed is unclear. Here, we report that, unlike adult pigs, only KCNQ1 (KV7.1) out of the five members of KCNQ genes was detected in neonatal pig renal microvessels. KCNQ1 is present in fetal pig kidneys as early as day 50 of gestation, and the level of expression remains the same up to postnatal day 21. Activation of renal vascular smooth muscle cell (SMC) KV7.1 stimulated whole cell currents, inhibited by HMR1556 (HMR), a selective KV7.1 blocker. HMR did not change the steady-state diameter of isolated renal microvessels. Similarly, intrarenal artery infusion of HMR did not alter mean arterial pressure, renal blood flow, and renal vascular resistance in the pigs. An ∼20 mmHg reduction in mean arterial pressure evoked effective autoregulation of renal blood flow, which HMR inhibited. We conclude that 1) the expression of KCNQ isoforms in porcine renal microvessels is dependent on kidney maturation, 2) KV7.1 is functionally expressed in neonatal pig renal vascular SMCs, 3) a decrease in arterial pressure up to 20 mmHg induces renal autoregulation in neonatal pigs, and 4) SMC KV7.1 does not control basal renal vascular tone but contributes to neonatal renal autoregulation triggered by a step decrease in arterial pressure.NEW & NOTEWORTHY KV7.1 is present in fetal pig kidneys as early as day 50 of gestation, and the level of expression remains the same up to postnatal day 21. KV7.1 is functionally expressed in neonatal pig renal vascular smooth muscle cells (SMCs). A decrease in arterial pressure up to 20 mmHg induces renal autoregulation in neonatal pigs. Although SMC KV7.1 does not control basal renal vascular resistance, its inhibition blunts neonatal renal autoregulation engendered by a step decrease in arterial pressure.
Removal of heavy metals using a novel sulfidogenic AMD treatment system with sulfur reduction: Configuration, performance, critical parameters and economic analysis

A novel sulfidogenic acid mine drainage (AMD) treatment system with a sulfur reduction process was developed. During the 220-d operation, > 99.9% of 380-mg/L ferric, 150-mg/L aluminum, 110-mg/L zinc, 20-mg/L copper and 2.5-mg/L lead ions, and 42.6-44.4% of 100-mg/L manganese ions in the synthetic AMD were step-by-step removed in the developed system with three pre-posed metal precipitators and a sulfur reduction reactor. Among them, zinc, copper and lead ions were removed by the biogenic hydrogen sulfide that produced through elemental sulfur reduction; while ferric, aluminum and manganese ions were removed by the alkali precipitation. Compared with the reported sulfate reduction reactors, the sulfur reduction reactor significantly reduced the chemical cost by 25.6-78.9% for sulfide production, and maintained a high sulfide production rate (1.12 g S2-/L-d). The pH level in the sulfidogenic reactor driven by sulfur-reducing bacteria posed a significant effect on the sulfide production rate. Under a nearly neutral condition (pH 7.0-7.5), elemental sulfur dissolved into polysulfide to increase the bioavailability of S-0. At acidic conditions (pH < 6.0), polysulfide formation was limited and sulfate reduction became dominant. Therefore, maintaining the sulfidogenic reactor driven by sulfur-reducing bacteria at neutral condition is essential to realize high-rate and low-cost AMD treatment. Moreover, the escape of residual hydrogen sulfide from the system was eliminated by employing a 17% recirculation from effluent to the sulfidogenic reactor.
Acoustic and Kinematic Correlates of Heterosyllabicity in Different Phonological Contexts

We investigate the temporal and kinematic properties of consonant gemination and heterosyllabic clusters as opposed to singletons and tautosyllabic clusters in Italian. The data show that the singleton versus geminate contrast is conveyed by specific kinematic properties in addition to systematic durational differences in both the consonantal and vocalic intervals; by contrast, tautosyllabic and heterosyllabic clusters differ significantly for the duration of the consonantal interval but do not vary systematically with respect to the vocalic interval and cannot be consistently differentiated at the kinematic level. We conclude that systematic variations in acoustic vowel duration and the kinematics of tongue tip gestures represent the phonetic correlates of the segmental phonological contrast between short and long consonants, rather than of syllable structure. Data are only partly consistent with the predictions of both moraic and gesture-based models of the syllable about the effects of syllable structure on speech production dynamics and call for a more gradient view of syllabification.
Human Factors and Ergonomics in Healthcare: Industry Demands and a Path Forward

This article reviews three industry demands that will impact the future of Human Factors and Ergonomics in Healthcare settings. These demands include the growing population of older adults, the increasing use of telemedicine, and a focus on patient-centered care. Following, we discuss a path forward through improved medical teams, error management, and safety testing of medical devices and tools. Future challenges are discussed.
Tenacibaculosis in Norwegian Atlantic salmon (Salmo salar) cage-farmed in cold sea water is primarily associated with Tenacibaculum finnmarkense genomovar finnmarkense

Skin conditions associated with Tenacibaculum spp. constitute a significant threat to the health and welfare of sea-farmed Atlantic salmon (Salmo salar L.) in Norway. Fifteen presumptive tenacibaculosis outbreaks distributed along the Norwegian coast during the late winter and spring of 2018 were investigated. Bacteriological culture confirmed the presence of Tenacibaculum spp. Seventy-six isolates cultured from individual fish were selected and subjected to whole-genome sequencing and MALDI-TOF MS analysis. Average nucleotide identity and MALDI-TOF analyses confirmed the presence of T. finnmarkense and T. dicentrarchi, with further division of T. finnmarkense into genomovars (gv.) finnmarkense and ulcerans. Core genome multilocus sequence typing (cgMLST) and single-nucleotide polymorphism (SNP) analyses identified the presence of a genetically conserved cluster of gv. finnmarkense isolates against a background of relatively genetically diverse gv. finnmarkense and gv. ulcerans isolates in 13 of the 15 studied cases. This clustering strongly suggests a link between T. finnmarkense gv. finnmarkense and development of clinical tenacibaculosis in sea-farmed Norwegian salmon in the late winter and spring. Analysis of 25 Tenacibaculum isolates collected during the spring of 2019 from similar cases identified a similar distribution of genotypes. Low water temperatures were common to all cases, and most incidences involved relatively small fish shortly after sea transfer, suggesting that these fish are particularly predisposed to Tenacibaculum infection.
Asymmetric impact of energy consumption and economic growth on ecological footprint: Using asymmetric and nonlinear approach

The main objective of this article is to examine the impacts of energy consumption and economic growth on environmental quality in Pakistan. We use the ecological footprint (environmental quality) as a target variable, the control variables of gross domestic products are a proxy of economic growth, and energy consumption and gross fixed capital formation arc proxies of capital from 1971 to 2014. For this purpose, a unit root test with break dates is employed for a stationary check, and a BDS test is used for nonlinearity. The nonlinear autoregressive distributed lag approach is employed to assess the asymmetric co-integration among the variables. These results confirm the asymmetric co-integration among the variables. The asymmetric causality technique is also applied to scrutinize the causal link between the variables. The asymmetric feedback effect is observed between positive shocks to environmental quality and energy consumption, and symmetrically, environmental quality causes energy consumption. By contrast, the neutral effect is observed among environmental quality, economic growth, and capital. Based on these findings, current energy portfolios should be diversified by either enhancing or incorporating renewable energy technologies, and this is indispensable to support the existing successful strides of environmental policies. Thus, policymakers must buttress their commitments to reduce emissions by sustaining and decarbonizing the trajectory of economic growth. (C) 2020 Elsevier B.V. All rights reserved.
Evidence-Based Considerations Exploring Relations between SARS-CoV-2 Pandemic and Air Pollution: Involvement of PM2.5-Mediated Up-Regulation of the Viral Receptor ACE-2

The COVID-19/SARS-CoV-2 pandemic struck health, social and economic systems worldwide, and represents an open challenge for scientists -coping with the high inter-individual variability of COVID-19, and for policy makers -coping with the responsibility to understand environmental factors affecting its severity across different geographical areas. Air pollution has been warned of as a modifiable factor contributing to differential SARS-CoV-2 spread but the biological mechanisms underlying the phenomenon are still unknown. Air quality and COVID-19 epidemiological data from 110 Italian provinces were studied by correlation analysis, to evaluate the association between particulate matter (PM)(2.5)concentrations and incidence, mortality rate and case fatality risk of COVID-19 in the period 20 February-31 March 2020. Bioinformatic analysis of the DNA sequence encoding the SARS-CoV-2 cell receptor angiotensin-converting enzyme 2 (ACE-2) was performed to identify consensus motifs for transcription factors mediating cellular response to pollutant insult. Positive correlations between PM(2.5)levels and the incidence (r = 0.67,p< 0.0001), the mortality rate (r = 0.65,p< 0.0001) and the case fatality rate (r = 0.7,p< 0.0001) of COVID-19 were found. The bioinformatic analysis of the ACE-2 gene identified nine putative consensus motifs for the aryl hydrocarbon receptor (AHR). Our results confirm the supposed link between air pollution and the rate and outcome of SARS-CoV-2 infection and support the hypothesis that pollution-induced over-expression of ACE-2 on human airways may favor SARS-CoV-2 infectivity.
A Novel Quantum Dot-Based pH Probe for Long-Term Fluorescence Lifetime Imaging Microscopy Experiments in Living Cells

The use of two nanoparticles for quantitative pH measurements in live cells by means of fluorescence lifetime imaging microscopy (FLIM) is investigated here. These nanoparticles are based on CdSe/ZnS quantum dots (QDs), functionalized with N-acetylcysteine (CdSe/ZnS-A) and with a small peptide containing D-penicillamine and histidine (CdSe/ZnS-PH). CdSe/ZnS-A has tendency to aggregate and nonlinear pH sensitivity in a complex medium containing salts and macromolecules. On the contrary, CdSe/ZnS-PH shows chemical stability, low toxicity, efficient uptake in C3H10T1/2 cells, and good performance as an FLIM probe. CdSe/ZnS-PH also has key advantages over a recently reported probe based on a CdSe/ZnS QD functionalized with D-penicillamine (longer lifetimes and higher pH-sensitivity). A pH(±2σ) of 6.97 ± 0.14 was determined for C3H10T1/2 cells by FLIM employing this nanoprobe. In addition, the fluorescence lifetime signal remains nearly constant for C3H10T1/2 cells treated with CdSe/ZnS-PH for 24 h. These results show the promising applications of this nanoprobe to monitor the intracellular pH and cell state employing the FLIM technique.
Integrated approach for optimal techno-economic planning for high renewable energy-based isolated microgrid considering cost of energy storage and demand response strategies

To realize an efficient energy supply system for an isolated microgrid, a joint design framework that considered the capacity sizing alongside operational planning is essential. In this work, an integrated planning model was developed to investigate the techno-economic performances of a high renewable energy-based standalone microgrid. The approach combines capacity sizing and operation scheduling, considering demand-side management strategies for different system design scenarios. The evaluated scenarios involved the combination of wind turbine, photovoltaic system, diesel generator, with either battery energy storage or pumped thermal energy storage. A demand response program based on instantaneous renewable energy availability is proposed with dynamic pricing economic model for improving the overall system flexibility. Mixed-integer linear programming algorithm on MATLAB (R) is deployed as the optimization solver. The minimization of the sum of system costs which includes equivalent annual costs of the investments, running costs and costs based on demand-side management strategies is the objective function. The combination of photovoltaic, wind turbine and pumped thermal energy storage is found to be the most techno-economically efficient system configuration for the considered microgrid. More so, the proposed demand response strategy minimizes the mismatch between the generation and the load demand profile effectively, thereby increasing the system flexibility.
Immunomodulation in the acute phase of autoimmune encephalitis

Autoimmune encephalitides constitute an emerging group of diseases for which the diagnosis and management may be challenging, and are usually associated with antibodies against neuroglial antigens used as biomarkers. In this review, we aimed to clarify the diagnostic approach to patients with encephalitis of suspected autoimmune origin in order to initiate early immunotherapy, and to summarize the evidence of current immunotherapies and alternative options assessed for refractory cases. Currently, the general therapeutic approach consists of steroids, IVIG, and/or plasma exchange as first-line medications, which should be prescribed once a diagnosis of possible autoimmune encephalitis is established. For patients not responding to these treatments, rituximab and cyclophosphamide are used as second-line immunotherapy. Additionally, alternative therapies, chiefly tocilizumab and bortezomib, have been reported to be useful in particularly refractory cases. Although the aforementioned approach with first and second-line immunotherapy is widely accepted, the best therapeutic strategy is still unclear since most available evidence is gathered from retrospective non-controlled studies. Moreover, several predictors of good long-term prognosis have been proposed such as response to first-line therapies, modified Rankin score lesser than 4 at the worst neurologic status, no need for admission in intensive care unit, and early escalation to second-line immunotherapy. Thus, the lack of solid evidence underlines the necessity of future well-conducted trials addressing both the best therapeutic regimen and the outcome predictors, but since autoimmune encephalitides have a relatively low incidence, international collaborations seem imperative to reach a reasonable study population size.
Pulmonary vascular resistance and compliance in pulmonary blood flow alterations in children with congenital heart disease

There is a unique hyperbolic relationship between pulmonary vascular resistance (Rp) and compliance (Cp); however, the characteristics of this coupling curve in pulmonary blood flow alterations remains unknown in children with congenital heart disease. We aimed to explore the Rp-Cp coupling and resistant-compliance (RC) time among them. We retrospectively reviewed catheterization data and calculated Rp and Cp in 217 subjects with ventricular septal defect. Median age and weight at catheterization were 2.8 (1.7-4.4) months and 4.3 (3.7-5.3) kg, respectively. Pulmonary hemodynamic parameters were as follows: mean pulmonary arterial pressure: 36 (28-43) mmHg; the amount of pulmonary blood flow (Qp): 14.2 (11.6-17.6) L/min/m2; Rp: 1.95 (1.38-2.59) Wood unit m2; Cp: 2.98 (2.42-3.88) mmHg/mL/m2; and RC time: 0.35 (0.30-0.40) s. RC time remained unchanged according to alterations in Qp (P = 0.206); however, the relationship between logarithm transformations of Rp and Cp showed more steeper according to an increase in Qp. The pulmonary circulation depends upon Cp rather than Rp according to the degree of Qp despite the constancy in RC time. We should take both Rp and Cp into consideration when evaluating the pulmonary circulation among children with congenital heart disease.
Melatonin inhibits Gram-negative pathogens by targeting citrate synthase

Bacterial infections caused by Gram-negative pathogens represent a growing burden for public health worldwide. Despite the urgent need for new antibiotics that effectively fight against pathogenic bacteria, very few compounds are currently under development or approved in the clinical setting. Repurposing compounds for other uses offers a productive strategy for the development of new antibiotics. Here we report that the multifaceted melatonin effectively improves survival rates of mice and decreases bacterial loads in the lung during infection. Mechanistically, melatonin specifically inhibits the activity of citrate synthase of Gram-negative pathogens through directly binding to the R300, D363, and H265 sites, particularly for the notorious Pasteurella multocida. These findings highlight that usage of melatonin is a feasible and alternative therapy to tackle the increasing threat of Gram-negative pathogen infections via disrupting metabolic flux of bacteria.
Immunogenicity of the COVID-19 Two-Vaccination Series Among Hematologic Malignancies: Report of Three Cases of Breakthrough Infection

Data is limited on the immunogenicity of the COVID-19 two-vaccination series among patients with hematologic malignancies and current guidelines do not recommend routine monitoring for post-vaccine antibodies. However, we describe three patients who developed severe or critical COVID-19 infections six months after vaccination. This highlights the importance of routine testing of COVID-19 IgG Spike, semi-quantitative antibodies post-vaccination, particularly among immunocompromised patients.
Rainfall intensification increases nitrate leaching from tilled but not no-till cropping systems in the US Midwest

As global surface temperatures rise, the percentage of total precipitation that falls in extreme events is increasing in many areas ("rainfall intensification"), including the U.S. Midwest, a major agricultural region. While it is well known that losses of nitrogen (N) fertilizers applied in excess of crop N demand have consequences for non-agricultural ecosystems, the effects of rainfall intensification on N losses from agricultural fields are uncertain. We conducted a 234-day field experiment in which we evaluated the effects of rainfall intensification on N leaching, soil inorganic N pools, soil N transformations, and crop N content in replicated tilled and no-till row crop systems of the upper Midwest. Under rainfall exclusion shelters we exposed 5x5m plots to a control rainfall treatment with relatively small, frequent rainfall events historically typical of the region, and an intensified rainfall treatment with the same total rainfall added in larger, less frequent events. Although rainfall intensification increased modeled water percolation to 1.2m in both tilled and no-till systems, as reported previously, it increased nitrate leaching only in tilled systems. Extractable soil nitrate concentrations throughout the experiment were on average 32 % higher in surface soils exposed to intensified rainfall compared to control rainfall regardless of tillage management. In-situ net N mineralization and nitrification rates measured during a two-week period in summer showed no significant differences between rainfall or tillage treatments. Inorganic N pools (0-1.2m depth) were 43 % greater in no-till soils compared to tilled soils and were unaffected by rainfall intensification; crop N concentrations and total N were likewise unaffected. Our results suggest that rainfall intensification in tilled cropping systems will increase N leaching to groundwater, with consequent economic and environmental harm. No-till management, however, may buffer systems against the effects of intensification on nitrate loss.
Microwave Pyrolysis of Macadamia Shells for Efficiently Recycling Lithium from Spent Lithium-ion Batteries

To reduce harm to the environment and human health and improve economic benefits, the large number of spent lithium-ion batteries that have been produced in recent years need to be reasonably recycled. The purpose of this article is to study a new method, microwave pyrolysis of the shells of macadamia nuts, for efficient recycling of lithium from spent lithium-ion batteries. XRD, SEM, and TGA analyses were used to observe the phase change during roasting. With the help of microwave heating and biomass pyrolysis, the decomposition temperature of Li(Ni1/3Co1/3Mn1/3)O-2 was reduced to 300 degrees C. Carbonated water-soluble Li2CO3 was formed under the action of biochar. Accordingly, the effects of pyrolysis temperature (Pte), biomass dose (bio%), reduction roasting temperature (Rte) and reduction roasting time (Rti) on the leaching rate of lithium were studied, and the results indicated that 93.4% lithium could be leached under the following optimum conditions: bio% = 24, Pte = 500 degrees C, Rte = 750 degrees C, and Rti = 25 min. A lattice collapse model and coupling reaction theory explained the benefit of biomass pyrolysis on the decomposition of Li(Ni1/3Co1/3Mn1/3)O-2. Finally, we designed a complete process for recycling the cathode powder of spent lithium-ion batteries. This study can guide industrial production to recover lithium-ion batteries in the future.