ahmedabdelwahed/Medical_papers_title_and_abstract_NLP_dataset huggingface dataset:
Recent progress in the pig-to-nonhuman primate kidney transplantation model: Report of a symposium

Three excellent presentations at an industry-sponsored symposium at the (virtual) congress of the combined IXA/CTRMS (September 23-25, 2021) were directed to the value and limitations of the pig-to-nonhuman primate (NHP) kidney transplantation model. Daniel Firl and James Markmann provided a meta-analysis comparing the results of kidney allotransplantation and xenotransplantation in NHPs during the past 25 years. Remarkably, the authors had identified 73 published reports that included 910 individual experiments. Although recipient survival after allotransplantation was longer, the superiority over the survival of xenografts was less than anticipated. Given the excellent short- and medium-term results of clinical kidney allotransplantation today, these data provide hope that the results of clinical pig kidney xenotransplantation may prove significantly better than in NHPs. The authors identified several factors that were shown to statistically influence the success or failure of xenotransplantation. Jean Kwun provided valuable information relating to the longstanding question of whether the survival of a pig organ would be jeopardized if transplanted into an allosensitized recipient. He demonstrated that pig kidney transplantation in an HLA-sensitized patient may be at a disadvantage, although multiple genetic engineering of the organ-source pig significantly delayed rejection. In the initial clinical trials, therefore, it would seem wise to exclude any patient with evidence of anti-HLA antibodies. Andrew Adams reported longer survival (>1 year) of Rhesus monkeys with life-supporting pig kidney grafts than has been achieved previously. Although not consistently achieved, these excellent results were obtained with an anti-CD154mAb-based regimen after CD4+ T cell and partial CD20+ B cell depletion. Factors that might have contributed to this success, including the phenotype of the pig, the species of the recipient, the recipient's anti-pig antibody level, and the immunosuppressive regimen, were discussed. Importantly, pig kidney function appeared to be normal in long-term surviving monkeys. Each study contributed to our goal of introducing xenotransplantation into the clinic.
Carbon emission effect of energy transition and globalization: inference from the low-, lower middle-, upper middle-, and high-income economies

The importance of income to environmental sustainability especially in the perspective of economic development has been rigorously examined in recent times. To further deepened the income-environmental sustainability narrative, the current study explore the cases of income-classified countries vis-a-vis the high-income, low-income, lower middle-income, and the upper middle-income countries and territories. As such, the current study examined the impact of renewable energy and fossil fuel energy consumption and globalization on CO(2)emissions over the period of 1970 to 2014 for the case of (1) the panel of income-classified countries and territories and (2) the time series of each of the income-classification. By employing the Pooled Mean Group of the Autoregressive Distributed Lag (ARDL) approach, the study found that fossil fuel consumption in the panel of examined income classification aggravates environmental hazards in both the short-long run, while the share of renewable energy usage improves the environmental quality only in the short run. Like the renewable energy consumption, globalization exacts negative and positive impacts in the short run and long run, respectively. From the second (time series) approach, the study found that fossil fuel energy worsen the environment in each of the fours income-categorized economies. Similarly, renewable energy usage exerts a significant and desirable impact on the environment in all but one (lower middle income) of the four income-categorized economies. However, globalization observably plays a significant and desirable role only in the lower middle-income economies. Hence, the study posits policy guide in the context of increased diversification of energy portfolio for each of the four income-categorized countries and territories especially the lower middle-income economies.
Measuring and modeling energy resilience

Resilience is a hot topic within the international development agenda and Sustainable Development Goals. Nowadays, resilience plays a crucial role in improving the quality of life of vulnerable categories and is designed as a major strategy to face the diverse dimensions and dynamics of vulnerability. Energy results among the most relevant fields of applications of resilience policies, especially when it comes to electricity. As a multidimensional concept, energy resilience policies must relate to the dimensions of sustainability - here considered as the interplay between the economic, social, environmental and governance dimensions. Due to the complexity of the phenomenon, energy resilience can be effectively outlined making use of composite indicators techniques. This paper presents the following new results: i) energy resilience is defined and ranked, strengthening a composite indicator for both OECD and non-OECD countries; the determinants of energy resilience are investigated; ii) an innovation on the construction of the World Bank's Regulatory Indicators on Sustainable Energy is operated. Our exercise makes use of an approach based on interval data to assess the sensitivity of the measure from different specifications. For the same scope, the robustness of the ranks obtained is analyzed through an uncertainty analysis. These choices aim to enhance the soundness and the validity of the composite indicator. The methodology provides a more reliable baseline to validate the results and the conceptual assumptions undertaken. It is found that, according to the diverse theoretical frameworks and methodologies applied, some countries vary considerably both in the pillars that aggregate the variables and within the minima, the centers, and the maxima of the intervals.
Estimating environmental efficiency and convergence: 1980 to 2016

Environmental performance assessment has been on the forefront of global economic growth discussions for the past decades. The study of efficiency growth and convergence is important to enable countries to evaluate their uses of inputs and embrace technologies to increase productivity. Using the Malmquist-Luenberger productivity index, this paper investigated the environmental performance of a panel of 104 countries over the period 1980 to 2016. Absolute and conditional beta convergence was analyzed and the possibility of clustering based on the club convergence was also analyzed. The findings show that average global environmental efficiency growth over the period is 1.3%. Convergence in environmental growth is conditional on industrial structure, globalization and energy price. The results also indicate the formation of club clusters in a sub sample of every decade but not in the entire period of study. Policy implications are also suggested. (C) 2020 Elsevier Ltd. All rights reserved.
Comparison of Biochemical Parameters and Pathomorphological Changes in Rats Receiving Standard and High-Fat Diets during Modeling of Streptozotocin Diabetes

The use of a high-fat diet, along with streptozotocin administration, can provide more profound insight into the mechanism of development of complications in diabetes, as well as their treatment. High-fat diet given over 3 weeks before intraperitoneal injection of streptozotocin in a dose of 40 mg/kg promoted the appearance of hyperglycemia in Wistar rats. The biochemical analysis of blood serum revealed increased levels of urea, triglycerides, cholesterol, AST, ALT, and concentration of inorganic phosphates and K+ ions in the high-fat diet group in comparison with the control. Both the biochemical analysis of the blood and histological analysis showed more pronounced abnormalities in rats receiving high-fat diet in comparison with animals receiving standard ration. These changes are the early markers for the development of nephropathy, impaired liver function, and microvascular disorders typical of patients with diabetes mellitus.
Protective role of scutellarin on LPS induced - Acute lung injury and regulation of apoptosis, oxidative stress and reduction of mitochondrial dysfunction

Lung fluid accumulation was determined using wet/dry lung mass ratio. Rats subjected to LPS-induced acute lung injury (2.8 ± 0.33, P < 0.05) presented with a significantly higher wet to dry lung weight ration ratio than sham rats (1.6 ± 0.23, P < 0.05). These results demonstrate that acutely inured rats' lungs were oedematous. On the other hand, treatment with scutellarin alone and in combination with a JNK inhibitor, SP600125, both significantly attenuated pulmonary edema as shown via reduced wet/dry lung mass ratios (1.7 ± 0.09 and 1.8 ± 0.23; P < 0.05, respectively). These results showed that the interventions were effective against LPS-induced edema of the lungs. However, the difference between treatment groups' weight ratios was not statistically significant (P > 0.05). In the sham control rats, the levels of ROS and SOD production were maintained at a low and at a high concentration, respectively (P < 0.05). However, following LPS infusion, the ROS levels skyrocketed while that of SOD decreased significantly relative to the control rats (P < 0.05). Furthermore, we noted that pre-treatment with scutellarin reduced the ROS levels in LPS-injured rats while the SOD was increased to near control levels (P < 0.05). Moreover, the combined effect of scutellarin and JNK inhibitor SP600125 on the levels of ROS and the SOD activity followed a similar trend to that of scutellarin alone albeit with a lower magnitude of change. Our results also showed that the combinatorial treatment was not significantly different from scutellarin alone in terms of influence on the levels of ROS production and SOD activity (P > 0.05). The effect of Scutellarin on broncho-alveolar lavage fluid (BALF) cytokine secretion The expression of interleukins-1β, -18 and -6 in the broncho-alveolar lavage fluid were significantly upregulated by LPS infusion (P < 0.05). The rise was, however, attenuated via pre-treatment with scutellarin only or in conjunction with SP600125, a JNK inhibitor (all P < 0.05). On the contrary, we observed that LPS injection caused a reduction of interlekins -4 and -10 secreted in the BALF. Pre-treatment with scutellarin alone (P < 0.05) and not in combination with SP600125 or SP600125 was able to significantly reverse this noted down-regulation (all P > 0.05).
Clinical and Radiological Factors Affecting Thoracolumbar Fractures Outcome: WFNS Spine Committee Recommendations

To obtain a list of recommendations about clinical and radiological factors affecting outcome in thoraco-lumbar fractures with the aim of helping spine surgeons in daily practice. A systematic literature search in PubMed and Google Scholar database was done from 2010 to 2020 on the topic "thoracolumbar fracture AND radiology AND surgical outcomes" and "thoracolumbar fracture AND radiology AND surgical outcomes." A total of 58 papers were analyzed and WFNS (World Federation of Neurosurgical Societies) Spine Committee organized 2 consensus meetings to formulate the specific recommendations the first in Peshawar in December 2019 and in a subsequent virtual meeting in June 2020 to reach an agreement. Both meetings utilized the Delphi method to analyze preliminary literature review statements based on the current evidence levels to generate recommendations through a comprehensive voting session. Eight statements were presented and reached the consensus about this topic. A variety of clinical factors is known to influence outcome of patients with thoracolumbar fractures. Some of these are well-known established factors such as blood pressure augmentation and patient age, while some are not well studied. Overall, the quality of evidence is low and we need more randomized controlled studies to validate our results. Similarly, radiological factors that can predict outcome are well stated and there is a high accordance worldwide. In reverse, still under debate is the application to choose which surgical treatment is advisable based on them.
Comparative analysis of drivers of energy consumption in China, the USA and India - A perspective from stratified heterogeneity

With the limited amount of resources, developing effective strategies to make full use of them and decrease the energy consumption without too much sacrifice of economic output requires identifying key drivers of energy consumption growth rate as a prerequisite. Meanwhile, as top three consumers of primary energy of the world, China, the United States of America, and India burn over 45% of global fuels in 2016. Conducting an empirically comparative analysis of them can also set up pilot scheme for other economies to develop more efficient strategies for energy consumption. The paper modified the original Geographical Detector model with a different sampling method to detect the key driver of energy consumption growth rate, which filling the gap that there are possible interactions of potential factors. The results show that coal intensity is the biggest driver to change overall energy consumption growth rate in China and India. In comparison, for the United States, the leading drivers of energy use are the factors of individual incomes and oil intensity. In addition, all factors have interactions and enhance each other when influencing total energy consumption growth rate. India has the strongest factor interactions when influencing the energy consumption growth rate among the three economies, all interactions between factors in US is not significant as those in China and India. Besides providing outcomes that can contribute towards developing new strategies to use energy more efficiently, this research offers a pilot example of analyzing energy issues from the perspective of stratified heterogeneity in consideration the characteristic differences of each factor. (C) 2019 Elsevier B.V. All rights reserved.
Prediction of chlorophenols adsorption on activated carbons by representative pores method

The specification of a particular activated carbon adsorbents for removal of phenol and related derivatives, from dilute aqueous solutions, is still based on lengthy trial and error experimental tests. A predictive model of adsorption of these compounds would considerably reduce the carbon selection time and could also bring new information to support more efficient carbon synthesis. The use of molecular simulation and the methodology of representative pores proved to be adequate for quantitative prediction of phenol adsorption. Here the methodology is being extended to chlorophenols, an important class of phenol-derived pollutants. A set of ortho- and para-chlorophenol isotherms were simulated for different representative pores in order to predict carbon adsorption and determine the most significative pore size. At low concentrations (1 × 10-4 mol/L), the pores of 8.9 and 18.5 Å are the most effective. For concentrations above 3 × 10-4 mol/L, pores in the range of 27.9 Å must be present in the activated carbon. The simulation predicts a step for the 27.9 Å pore that can be correlated with experimental steps in literature. Finally, the adsorption isotherms of chlorophenols for other activated carbons were predicted with the help of the model.
Urban heat stress and human health in Bangkok, Thailand

Heat stress has been recognized as one of the consequences of climate change in urban areas. Its adverse effects on the urban population range from economy, social, environment, and human health. With the increasing urbanization and economic development in cities, heat stress is expected to worsen. This particular study aims to achieve two objectives: (1) to understand the determinants of heat stress, especially the roles of the urban environment in exacerbating the heat stress, and (2) to explore the effects of heat stress to human health using self-reported health assessment. We employed a cross-sectional study using a survey questionnaire from 505 respondents living in the urban area of Bangkok, Thailand. We found that socioeconomic conditions of the individual and urban environment were significant determinants of urban heat stress. Low-income urban populations living in high-density areas with less green open space were more likely to experience heat stress. We also found that heat stress significantly affects human health. Those who reported a higher level of heat stress were more likely to have adverse health and well-being outcomes. The findings suggest that the increased risk of heat stress represents a major problem in the Bangkok, Thailand. It is necessary to address heat stress in adaptation policy and measures at the city levels amid the continued increase of global temperature and climate change.
Antiplatelet therapy in cardiovascular disease: Current status and future directions

Antiplatelet medications remain a cornerstone of therapy for atherosclerotic cardiovascular and cerebrovascular diseases. In primary prevention (patients with cardiovascular risk factors but no documented events, symptoms or angiographic disease), there is little evidence of benefit of any antiplatelet therapy, and such therapy carries the risk of excess bleeding. Where there is documented disease (secondary prevention), stable patients benefit from long-term antiplatelet monotherapy, aspirin being first choice in those with coronary heart disease and clopidogrel in those with cerebrovascular disease; moreover, recent evidence shows that low-dose rivaroxaban in combination with aspirin confers added benefit, in patients with stable cardiovascular and peripheral arterial disease. In patients with acute cerebrovascular disease, aspirin combined with clopidogrel reduces subsequent risk, while in acute coronary syndrome, dual antiplatelet therapy comprising aspirin and a P2Y12 inhibitor (clopidogrel, prasugrel or ticagrelor) confers greater protection than aspirin monotherapy, with prasugrel and ticagrelor offering greater antiplatelet efficacy with faster onset of action than clopidogrel. Although greater antiplatelet efficacy is advantageous in preventing thrombotic events, this must be tempered by increased risk of bleeding, which may be a particular issue in certain patient groups, as will be discussed. We will also discuss possible future approaches to personalisation of antiplatelet therapy.
Morphological and immunohistochemical characterization and molecular classification of spontaneous mammary gland tumors in macropods

Mammary gland neoplasms in macropods are uncommonly reported, and the morphological and immunohistochemical characteristics are incompletely described. The goal of this study was to describe the morphologic features of macropod mammary neoplasms and to determine the molecular subtypes of mammary carcinomas using a panel of antibodies against estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (Her-2), p63, smooth muscle actin (SMA), and epidermal growth factor receptor (EGFR). Biopsy and necropsy specimens were examined from 21 macropods with mammary tumors submitted to Northwest ZooPath from 1996 to 2019. In accordance with the histologic classification of canine mammary tumors proposed by Goldschmidt and colleagues, tubulopapillary (2), tubular (10), and comedo-carcinomas (2), adenoma (1), lobular hyperplasia (3), fibroadenomatous hyperplasia (1), and mastitis (2) were diagnosed. Red kangaroos (Osphranter rufus) were most commonly diagnosed with mammary carcinomas (79% of all carcinomas). Seven carcinomas had lymphovascular invasion and 2 also had pulmonary metastases. Six of these 7 carcinomas were classified as grade 3. Immunohistochemistry (IHC) for all antibodies was performed on 9/14 carcinomas, and partial IHC was performed for 3 cases. All 12 carcinomas were immunoreactive for PR, 5 for ER, 9 for EGFR, and none for Her-2. Five of the 9 mammary carcinomas with complete IHC data were classified as luminal A subtype, and 4 were normal-like subtype. Accurate classification of mammary tumors in macropods based on morphology, immunohistological characteristics, and molecular subtype may be helpful in guiding clinical management, prognosis, and potential therapeutic targets.
[Effects of the COVID-19 pandemic on health inequalities and mental health: effective public policies]

The aim of this article is to examine the effects of the COVID-19 pandemic on health inequalities and mental disorders and to analyse the most effective public policies in containing them. COVID-19, in addition to causing the worst health crisis since World War II, has generated a severe economic recession and a rise in unemployment. The poorer socioeconomic classes have been most affected by infections and deaths caused by the SARS-CoV-2 virus due to inequalities in working, housing and area of ​​residence conditions, psychosocial factors, and unequal access to health care. The pandemic crisis, in addition to causing psychiatric and neurological problems in people who have been hospitalized, appears to have increased the risk of psychological problems through various mechanisms such as social distancing, loss of a loved one, unemployment, and economic difficulties. In many countries, however, there was no significant increase in suicides in 2020 and there have even been decreasing temporal trends. It is possible that the crisis, in addition to creating stress and social isolation, may have promoted reciprocity, interpersonal help, and greater motivation to take care of one's health.The most effective policies in reducing COVID-19 mortality have the potential to limit the most adverse effects of the pandemic on health inequalities and mental health. Thanks to vigorous preventive interventions on the territory, based on testing, tracing, isolating, timely, countries who managed best the pandemic avoided prolonged and repeated lockdowns, protected public health and the economy. However, more vigorous social protection measures are needed in favour of those populations most affected by the health crisis and its socioeconomic effects. This pandemic offers the opportunity to learn lessons on the protection of public health and stress the need to adopt a syndemic model oriented towards prevention.
Thermodynamic and thermoeconomic analysis of a novel ammonia-water mixture combined cooling, heating, and power (CCHP) cycle

In this research, a new ammonia-water mixture CCHP system driven by a LTHS is proposed which is a modified version of a Kalina cycle. Feasibility investigation of the recommended system is studied based on thermodynamic and thermoeconomic balance equations for performance assessment of thermal systems. the energy efficiency, exergy efficiency, and overall unit product cost are computed 49.83%, 27.68%, and 198.3 $/GJ, respectively. Also, condenser 2 is characterized as the main contributor to irreversibility of the recommended trigeneration system by exergy destruction ratio of 32.03%. Moreover, a thorough sensitivity study is carried out to attain higher energy efficiency by raising the evaporation temperature and basic NH3 concentration or by reducing the separators pressure, heating unit temperature, and terminal temperature difference (TTD) of vapour generator. From exergy perspective, it is figured out that higher exergy efficiency may be achieved by raising the separator 1 pressure, and TTD of vapour generator or by reducing the separator 2 pressure, evaporation temperature, heating unit temperature, and basic NH3 concentration. Also, it is proven that the overall cost of the cycle can be peaked with evaporation temperature, while can be maximized with separator 1 pressure and basic ammonia concentration. (C) 2019 Elsevier Ltd. All rights reserved.