ahmedabdelwahed/Medical_papers_title_and_abstract_NLP_dataset huggingface dataset:
Axin2+ PDL Cells Directly Contribute to New Alveolar Bone Formation in Response to Orthodontic Tension Force

Wnt-β-catenin signaling plays a key role in orthodontic tooth movement (OTM), a common clinical practice for malocclusion correction. However, its targeted periodontal ligament (PDL) progenitor cells remain largely unclear. In this study, we first showed a synchronized increase in Wnt-β-catenin levels and Axin2+ PDL progenitor cell numbers during OTM using immunostaining of β-catenin in wild-type mice and X-gal staining in the Axin2-LacZ knock-in line. Next, we demonstrated time-dependent increases in Axin2+ PDL progenitors and their progeny cell numbers within PDL and alveolar bones during OTM using a one-time tamoxifen-induced Axin2 tracing line (Axin2CreERT2/+; R26RtdTomato/+). Coimmunostaining images displayed both early and late bone markers (such as RUNX2 and DMP1) in the Axin2Lin PDL cells. Conversely, ablation of Axin2+ PDL cells via one-time tamoxifen-induced diphtheria toxin subunit A (DTA) led to a drastic decrease in osteogenic activity (as reflected by alkaline phosphatase) in PDL and alveolar bone. There was also a decrease in new bone mass and a significant reduction in the mineral apposition rate on both the control side (to a moderate degree) and the OTM side (to a severe degree). Thus, we conclude that the Axin2+ PDL cells (the Wnt-targeted key cells) are highly sensitive to orthodontic tension force and play a critical role in OTM-induced PDL expansion and alveolar bone formation. Future drug development targeting the Axin2+ PDL progenitor cells may accelerate alveolar bone formation during orthodontic treatment.
Research on the incorporation of untreated flue gas desulfurization gypsum into magnesium oxysulfate cement

The growing concern of low-carbon economy and sustainable development has obliged the researchers to investigate green building materials through utilizing industrial by-products. In this study, the industrial waste material, flue gas desulfurization gypsum (FGDG), is incorporated into the magnesium oxysulfate cement (MOSC). The performance of FGDG-incorporated MOSC is evaluated by testing the setting time, compressive strength, density, water absorption, water resistance, volume stability and SO42- releasing. The hydration products are detected by X-ray diffraction, while microstructure is observed by optical microscope and scanning electron microscope. Increasing the proportion of FGDG retards the initial and final setting times of paste. Compressive strength for MOSC mixtures varies from 52.4 to 62.4 MPa at hydration age of 3 days. The water absorption and the release of SO42- increase when increasing the FGDG content. The FGDG-incorporated MOSC presents a superior water resistance and volume stability in contrast with the FGDG-free MOSC. The main hydration products of the paste are Mg(OH)(2) and 5 Mg(OH)(2)center dot MgSO4 center dot 7H(2)O (5.1.7) phase. The microstructure analysis is in agreement with the results of mechanical properties. Finally, the FGDG-incorporated MOSC is identified as a promising building material by the evaluation of economic and environmental sustainability. (C) 2020 Elsevier Ltd. All rights reserved.
Exploring indicators of circular economy adoption framework through a hybrid decision support approach

Circular economy (CE) focuses on a circular approach to energy and material resources, which provides economic, environmental and social benefits for manufacturing organisations. CE adoption in emerging economies facilitates in substantial economic growth through appropriate utilisation of energy and material resources across manufacturing industries. This study identifies CE indicators in the context of an emerging economy. The study further develops a framework for the adoption of CE and tests it through a hybrid Best Worst Method and Decision-Making Trial and Evaluation Laboratory approach. The framework is validated through an Indian manufacturing case organisation. While Best Worst Method computes the CE related indicator weights, Decision-Making Trial and Evaluation Laboratory analyses the inter-relationship among indicators. Disparate CE related indicators, e.g. strategic, managerial, informational and technological, supply chain and organisational, influence the CE adoption in an emerging economy context. The findings reveal that the strategic and managerial indicators have the strongest influence on developing other indicators. The causal digraph and relationship diagram assist the practitioners in predicting the inter-relationship of indicators in CE adoption. The study outcomes will help the practitioners, policymakers and researchers to draw a framework for adoption of circular and green practices and usage of resources sustainably. (C) 2020 Elsevier Ltd. All rights reserved.
Artesunate induces substantial topological alterations in the SARS-CoV-2 Nsp1 protein structure

The need for novel antiviral treatments for coronavirus disease 2019 (COVID-19) continues with the widespread infections and fatalities throughout the world. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the deadly disease, relies on the non-structural protein Nsp1 for multiplication within the host cells and disarms the host immune defences by various mechanisms. Herein, we investigated the potential of artemisinin and its derivatives as possible inhibitors of SARS-CoV-2 Nsp1 through various computational approaches. Molecular docking results show that artemisinin (CID68827) binds to Nsp1 with a binding energy of -6.53 kcal/mol and an inhibition constant of 16.43 µM. The top 3 derivatives Artesunate (CID6917864), Artemiside (CID53323323) and Artemisone (CID11531457) show binding energies of -7.92 kcal/mol, -7.46 kcal/mol and -7.36 kcal/mol respectively. Hydrophobic interactions and hydrogen bonding with Val10, Arg11, and Gln50 helped to stabilize the protein-ligand complexes. The pharmacokinetic properties of these molecules show acceptable properties. The geometric parameters derived from large-scale MD simulation studies provided insights into the changes in the structural topology of Nsp1 upon binding of Artesunate. Thus, the findings of our research highlight the importance of artemisinin and its derivatives in the development of drugs to inhibit SARS-CoV-2 Nsp1 protein.
Porous Ti3C2Tx MXene Membranes for Highly Efficient Salinity Gradient Energy Harvesting

Extracting osmotic energy through nanoporous membranes is an efficient way to harvest renewable and sustainable energy using the salinity gradient between seawater and river water. Despite recent advances of nanopore-based membranes, which have revitalized the prospect of blue energy, their energy conversion is hampered by nanomembrane issues such as high internal resistance or low selectivity. Herein, we report a lamellar-structured membrane made of nanoporous Ti3C2Tx MXene sheets, exhibiting simultaneous enhancement in permeability and ion selectivity beyond their inherent trade-off. The perforated nanopores formed by facile H2SO4 oxidation of the sheets act as a network of cation channels that interconnects interplanar nanocapillaries throughout the lamellar membrane. The constructed internal nanopores lower the energy barrier for cation passage, thereby boosting the preferential ion diffusion across the membrane. A maximum output power density of the nanoporous Ti3C2Tx MXene membranes reaches up to 17.5 W·m-2 under a 100-fold KCl gradient at neutral pH and room temperature, which is as high as by 38% compared to that of the pristine membrane. The membrane design strategy employing the nanoporous two-dimensional sheets provides a promising approach for ion exchange, osmotic energy extraction, and other nanofluidic applications.
A Novel, eco-friendly combined solar cooling and heating system, powered by hybrid Photovoltaic thermal (PVT) collector for domestic application

Solar heating and cooling technologies can have a vital role to play in understanding the targets in energy security, economic development, and mitigating climate change. This study aimed to investigate the performance of the combined solar cooling/heating system using a Photovoltaic Thermal collector (PVT) for residential applications. The main advantage of using PVT is the conversion of the maximum amount of solar energy into electricity and thermal energy. In this work, water is used to cool the panel and, consequently, increase the efficiency. The cooling cycle comprises a hybrid ejector-compression refrigeration cycle with two evaporator temperatures. To reduce the effect of the global warming phenomenon, two different refrigerants with lower Global Warming Potential (GWP), such as R600a and R290, are used instead of R134a. The inlet water does not only gain heat from the PVT but also the collector output water is heated in a condenser and heater. The results indicate that increasing the water mass flow rate from 0.011 kg/s to 0.03 kg/s (39-108 Lit/h) at solar intensity (G) of 945 W/m(2) results in enhancing the overall efficiency of the PVT system from 66.7% to 75.8%. In terms of the highest Coefficient of performance (COP) and the lowest exergy destruction, R290 shows better performance comparing to the other refrigerants. In more details, using R290, instead of R134a, results in up to 7.5% enhancement in the COP of the cycle. The water mass flow rate is optimized at m(w)=0.013 kg/s to achieve the highest COP and the lowest exergy destruction. Also, it is reported that the temperature of the outlet water from the system varies between 31.72 degrees C to 46.73 degrees C during the day. Finally, it is revealed that using R290 for the refrigeration cycle and cooling the panel result in enhancing the COP of the cycle by 11.1%, increasing the temperature of the outlet water from the system by 9.17 degrees C and decreasing the refrigerant flow rate by 60.17%, in comparison with a system without panel cooling which uses R134a refrigerant.
Host phenotype and microbiome vary with infection status, parasite genotype, and parasite microbiome composition

A growing literature demonstrates the impact of helminths on their host gut microbiome. We investigated whether the stickleback host microbiome depends on ecoevolutionary variables by testing the impact of exposure to the cestode parasite Schistocephalus solidus with respect to infection success, host genotype, parasite genotype, and parasite microbiome composition. We observed constitutive differences in the microbiome of sticklebacks of different origin, and those differences increased when sticklebacks exposed to the parasite resisted infection. In contrast, the microbiome of successfully infected sticklebacks varied with parasite genotype. More specifically, we revealed that the association between microbiome and immune gene expression increased in infected individuals and varied with parasite genotype. In addition, we showed that S. solidus hosts a complex endomicrobiome and that bacterial abundance in the parasite correlates with expression of host immune genes. Within this comprehensive analysis we demonstrated that (i) parasites contribute to modulating the host microbiome through both successful and unsuccessful infection, (ii) when infection is successful, the host microbiome varies with parasite genotype due to genotype-dependent variation in parasite immunomodulation, and (iii) the parasite-associated microbiome is distinct from its host and impacts the host immune response to infection.
Systematic review on activity of liposomal encapsulated antioxidant, antibiotics, and antiviral agents

Reactive oxygen species (ROS) like superoxide anion, hydrogen peroxide, and hydroxyl radical, can be formed as normal products of aerobic metabolism. Overproduction or insufficient removal of ROS results in significant damage to cell structure and functions. Antioxidants applied directly and at relatively high concentrations to cellular systems are effective in protection against the damaging actions of ROS. Microorganisms including Gram-positive and negative bacteria, fungi, protozoa, algae, etc., can be disease causing microorganism. Antimicrobial agents have the capability to inhibitor destroy the microorganisms. The problems arising from the use of antioxidant and antimicrobial agents include poor solubility, instability during storage, low bioavailability, and difficulty to reach target organs with sufficient doses. Liposomal antimicrobial agent and liposomal antioxidants enhance the solubility, bioavailability, and stability of antimicrobial agent and antioxidants.
The Impact of Population Aging and Public Health Support on EU Labor Markets

Population aging and public health expenditure mainly dedicated to older dependent persons present major challenges for the European Union (EU) Member States, with profound implications for their economies and labor markets. Sustainable economic development relies on a well-balanced workforce of young and older people. As this balance shifts in favor of older people, productivity tends to suffer, on the one hand, and the older group demands more from health services, on the other hand. These requisites tend to manifest differently within developed and developing EU countries. This research aimed to assess population aging impacts on labor market coordinates (employment rate, labor productivity), in the framework of several health dimensions (namely, health government expenditure, hospital services, healthy life years, perceived health) and other economic and social factors. The analytical approach consisted of applying structural equation models, Gaussian graphical models, and macroeconometric models (robust regression and panel corrected standard errors) to EU panel data for the years 1995-2017. The results show significant dissimilarities between developed and developing EU countries, suggesting the need for specific policies and strategies for the labor market integration of older people, jointly with public health expenditure, with implications for EU labor market performance.
Peer-to-peer electricity trading in grid-connected residential communities with household distributed photovoltaic

With the rapid development of distributed electricity generation technologies such as solar photovoltaics, peer to-peer (P2P) electricity trading is attracting incremental attention due to the pursuit of decentralized energy autonomy and further economic benefits. The study presented in this paper aims to gain a better understanding of the community P2P electricity trading, including influence of trading strategies, determinants of trading quantity and price, and further factors affecting improvement in community energy welfare. The market mechanism is determined based on the discriminatory continuous double auction, followed by simulations of the trading process in well-designed cases. Results show that P2P trading price and quantity depend on variation of the supply-demand ratio during each trading period, by which in the absence of complex trading strategies and learning abilities, profits are able to be effectively and fairly allocated among participants. For a given community, the total profits that could be obtained from P2P electricity trading are influenced by many factors, and the key is to make those "ineffective supply" available in the P2P market again, through active energy management solutions on all residents rather than focusing only on prosumers' self-consumption in the past. The ensuing results make significant sense as regards better understanding both the benefits and limitations of P2P electricity trading in residential communities or other similar scenes, thus helping for guiding practical implementation.
Associations Between Atrial Arrhythmias and Brain Amyloid Deposition: The ARIC-PET Study

The aim of this study is to determine if there is an association between atrial arrhythmias and brain amyloid-β (Aβ), measured on florbetapir (FBP) PET. 346 nondemented participants from the Atherosclerosis Risk in Communities study underwent FBP-PET, 185 also wore Zio® XT Patch. The associations between global cortical Aβ (> 1.2 standardized uptake value ratio) and history of atrial fibrillation, zio-defined atrial tachycardia and premature atrial contractions, each, were evaluated. Among nondemented community-dwelling older adults, we did not find an association between atrial arrhythmias and Aβ. Other brain pathology may underlie the association described between atrial arrhythmias and cognition.
An Efficient and Convenient Method for Isolation and Culturing of Neonatal Rat Cardiomyocytes

For isolation of neonatal rat cardiomyocytes (NRCM) the ventricular muscles of neonatal rats were treated with different digestive solutions: 0.06% trypsin (method I), 0.08% collagenase II (method II), 0.06% trypsin and 0.08% collagenase II for stepwise digestion (methods III and IV). After enzymatic dissociation of the tissue, the complete medium was added to stop this process. The cells suspensions obtained by methods I-III were collected and centrifuged. In contrast, the novel and improved method IV did not use centrifugation. Instead, various methods of adhesion were employed to separate non-myocardial cells. The isolation methods were compared by the quantity, survival rate, morphology, spontaneous pulsation rate, purity, and vitality of NRCM. These assessments showed that isolation method IV is a simple, efficient, and convenient way to obtain NRCM for culturing.
Piecewise Structural Equation Modeling of the Quantity Implicature in Child Language

We review an array of experimental methodological factors that either contribute to or detract from the measurement of pragmatic implicatures in child language. We carry out a truth value judgment task to measure children's interpretations of the Spanish existential quantifier algunos in implicature-consistent and implicature-inconsistent contexts. Independently, we take measures of children's inhibition, working memory, attention, approximate number ability, phrasal syntax, and lexicon. We model the interplay of these variables using a piecewise structural equation model (SEM), common in the life sciences, but not in the social and behavioral sciences. By 6 years of age, the children in our sample were not statistically different from adults in their interpretations. Syntax, lexicon, and inhibition significantly predict implicature generation, each accounting for unique variance. The approximate number system and inhibition significantly predict lexical development. The statistical power of the piecewise SEM components, with a sample of 64 children, is high, in comparison to a traditional, globally estimated SEM of the same data.
Beyond return of spontaneous circulation: update on post-cardiac arrest management in the intensive care unit

A well-functioning chain of survival is critical for good outcomes following out-of-hospital cardiac arrest, a major public health concern in Singapore. While the percentage of survivors to hospital admission has increased over the years, the percentage of survivors to hospital discharge and the number of patients with good neurological recovery can be greatly improved. This underscores the urgent need to focus on 'post-cardiac arrest care', the fifth link in the chain of survival, to improve the outcomes of patients who are admitted to the intensive care unit (ICU) after return of spontaneous circulation. This review builds on earlier recommendations of the Singapore National Targeted Temperature Management Workgroup in 2017 to provide a focused update on post-cardiac arrest management and a practical guide for physicians managing resuscitated patients with cardiac arrest in the ICU.
Potential innovation against Alzheimer's disorder: a tricomponent combination of natural antioxidants (vitamin E, quercetin, and basil oil) and the development of its intranasal delivery

Alzheimer's disorder (AD) is very difficult to manage and treat. The complexity of the brain, the blood-brain barrier influencing a multitude of parameters/biomarkers, as well as numerous other factors involved often contribute to the decline in the chances of treatment success. Development of the new drug moiety also takes time, being necessary to consider both its toxicity and related issues. As a strategic plan, a combined strategy is being developed and considered to address AD pathology using several approaches. A combination of vitamin E, quercetin, and basil oil in a nano-based formulation is designed to be administered nasally. The antioxidant present in these natural-based products helps to treat and alleviate AD if a synergistic approach is considered. The three active substances mentioned above are well known for the treatment of neurodegenerative disorders. The nanoformulation helps the co-delivery of the drug moiety to the brain through the intranasal route. In this review, a correlation and use of vitamin E, quercetin, and basil oil in a nano-based formulation is described as an effective way to treat AD. The intranasal administration of drugs is a promising approach for the treatment of neurodegenerative and mental disorders, as this route is non-invasive, enhances the bioavailability, allows a drug dose reduction, bypasses the blood-brain barrier, and reduces the systemic undesired effect. The use of natural products is generally considered to be just as safe; therefore, by using this combined approach, the level of toxicity can be minimized.
A mathematical model of the rat kidney. IV. Whole kidney response to hyperkalemia

The renal response to acute hyperkalemia is mediated by increased K+ secretion within the connecting tubule (CNT), flux that is modulated by tubular effects (e.g., aldosterone) in conjunction with increased luminal flow. There is ample evidence that peritubular K+ blunts Na+ reabsorption in the proximal tubule, thick ascending Henle limb, and distal convoluted tubule (DCT). Although any such reduction may augment CNT delivery, the relative contribution of each is uncertain. The kidney model of this laboratory was recently advanced with representation of the cortical labyrinth and medullary ray. Model tubules capture the impact of hyperkalemia to blunt Na+ reabsorption within each upstream segment. However, this forces the question of the extent to which increased Na+ delivery is transmitted past the macula densa and its tubuloglomerular feedback (TGF) signal. Beyond increasing macula densa Na+ delivery, peritubular K+ is predicted to raise cytosolic Cl- and depolarize macula densa cells, which may also activate TGF. Thus, although the upstream reduction in Na+ transport may be larger, it appears that the DCT effect is critical to increasing CNT delivery. Beyond the flow effect, hyperkalemia reduces ammoniagenesis and reduced ammoniagenesis enhances K+ excretion. What this model provides is a possible mechanism. When cortical [Formula: see text] is taken up via peritubular Na+-K+([Formula: see text])-ATPase, it acidifies principal cells. Consequently, reduced ammoniagenesis increases principal cell pH, thereby increasing conductance of both the epithelial Na+ channel and renal outer medullary K+ channel, enhancing K+ excretion. In this model, the effect of aldosterone on principal cells, diminished DCT Na+ reabsorption, and reduced ammoniagenesis all provide relatively equal and additive contributions to renal K+ excretion.NEW & NOTEWORTHY Hyperkalemia blunts Na+ reabsorption along the nephron, and increased CNT Na+ delivery facilitates K+ secretion. The model suggests that tubuloglomerular feedback limits transmission of proximal effects past the macula densa, so that it is DCT transport that is critical. Hyperkalemia also reduces PCT ammoniagenesis, which enhances K+ excretion. The model suggests a mechanism, namely, that reduced cortical ammonia impacts CNT transport by raising cell pH and thus increasing both ENaC and ROMK conductance.
The novel HLA-B*35:501 allele, identified by sanger dideoxy nucleotide sequencing in a Chinese individual

HLA-B*35:501 differs from HLA-B*35:02:01:01 by three nucleotides in exon 2.