ahmedabdelwahed/Medical_papers_title_and_abstract_NLP_dataset huggingface dataset:
Laser-induced graphene (LIG)-driven medical sensors for health monitoring and diseases diagnosis

Laser-induced graphene (LIG) is a class of three-dimensional (3D) porous carbon nanomaterial. It can be prepared by direct laser writing on some polymer materials in the air. Because of its features of simplicity, fast production, and excellent physicochemical properties, it was widely used in medical sensing devices. This minireview gives an overview of the characteristics of LIG and LIG-driven sensors. Various methods for preparing graphene were compared and discussed. The applications of the LIG in biochemical sensors for ions, small molecules, microRNA, protein, and cell detection were highlighted. LIG-based physical physiological sensors and wearable electronics for medical applications were also included. Finally, our insights into current challenges and prospects for LIG-based medical sensing devices were presented.
Transformation towards Circular Economy (CE) in Municipal Waste Management System: Model Solutions for Poland

Municipal waste management has been an area of special interest for the European Commission (EC) for many years, especially in the transformation process towards a circular economy (CE), which is a priority of the European Union's (EU's) economic policy. This paper presents the overview of the Polish waste management system (WMS) and the CE-related tasks indicated in the Polish CE Roadmap. Despite the fact that Poland is one of the countries that generates the least waste per capita (329 kg in 2018) in the EU (489 kg), it still has problems with adapting the levels of municipal waste recycling to European requirements (34.3% in 2018, EU average 47%), which result from the lack of sufficient infrastructure for waste management and the insufficiently developed public awareness and behaviors. The current paper presents an inventory of the recommended actions, which support transformation towards CE in municipal waste management. These actions have been grouped into six core principles of circularity, indicated in the ReSOLVE framework: Regenerate, Share, Optimize, Loop, Virtualize, and Exchange. In each of presented areas, recommended tasks and actions were identified that should be taken by governments and residents themselves, such as landfill remediation, use of selected municipal waste fractions for economic purposes, sharing products with co-users, waste recovery, remanufacturing products or components, virtual solutions in everyday life to reduce the amount of generated waste, or replacement of household appliances by items with a higher energy class. An implementation of specific actions indicated in the paper could positively influence transformation towards CE in Poland. Because the presented examples of actions are model solutions, they can also be used in other countries and regions.
Bayesian analysis under accelerated failure time models with error-prone time-to-event outcomes

We consider accelerated failure time models with error-prone time-to-event outcomes. The proposed models extend the conventional accelerated failure time model by allowing time-to-event responses to be subject to measurement errors. We describe two measurement error models, a logarithm transformation regression measurement error model and an additive error model with a positive increment, to delineate possible scenarios of measurement error in time-to-event outcomes. We develop Bayesian approaches to conduct statistical inference. Efficient Markov chain Monte Carlo algorithms are developed to facilitate the posterior inference. Extensive simulation studies are conducted to assess the performance of the proposed method, and an application to a study of Alzheimer's disease is presented.
Association of COVID-19 global distribution and environmental and demographic factors: An updated three-month study

We investigated the association of some environmental and economic factors and the global distribution indicators of the COVID-19 pandemic. Since the number of cases and deaths is higher in high-income countries located in higher latitudes and colder climates, further studies are required to shed light on this matter.
Mechanisms of cardiac dysfunction in diabetic cardiomyopathy: molecular abnormalities and phenotypical variants

Diabetic cardiomyopathy (DCM) is a diabetes mellitus-induced pathophysiological condition characterized by cardiac structural, functional, and metabolic changes that can result in heart failure (HF), in the absence of coronary artery disease, hypertension, and valvular heart disease. Metabolic alterations such as hyperglycemia, insulin resistance, hyperinsulinemia, and increased metabolism of free fatty acids result in oxidative stress, inflammation, advanced glycation end products formation, abnormalities in calcium homeostasis, and apoptosis that are responsible for structural remodeling. Cardiac stiffness, hypertrophy, and fibrosis eventually lead to dysfunction and HF with preserved ejection fraction and/or HF with reduced ejection fraction. In this review, we analyzed in detail the cellular and molecular mechanisms and the metabolic pathways involved in the pathophysiology of DCM. Different phenotypes are observed in DCM, and it is not clear yet if the restrictive and the dilated phenotypes are distinct or represent an evolution of the same disease. Phenotypic differences can be observed between T1DM and T2DM DCM, possibly explained by the different myocardial insulin action. Further studies are needed in order to better understand the underlying mechanisms of DCM and to identify appropriate therapeutic targets and novel strategies to prevent and reverse the progression toward heart failure in diabetic patients.
Energy consumption, economic expansion, and CO2 emission in the UK: The role of economic policy uncertainty

On the 23rd of June 2016, the United Kingdom voted to leave the EU, leading to months and years of economic policy uncertainties. Such uncertainties have not only characterized the UK but have become a center point for energy debate in recent times. Given the foregoing, this paper progresses to provide evidence on the role of Economic Policy Uncertainty in the Energy Consumption - Emission nexus in the UK. We use annual data spanning the period of 1985-2017 for the UK for CO2 emissions in tons per capita (CO2), real GDP (RGDP), energy use (EU), and economic policy uncertainty (EPU). The Autoregressive distributed lag model (ARDL) bound test is used to test the fitness of the model in the short and long term. Our model shows that EPU matters most in the short run, as it reduces the growth of CO2 emissions, while prolonged use of EPU in the UK, exhibit controversial influence, where CO2 emissions continue to rise. In addition, pairwise Granger causality shows a one-way causality running from energy use to CO2 emissions, CO2 emissions to economic policy uncertainty, and also from energy use to economic policy uncertainty. However, two-ways causality is found between real GDP and real GDP per capita. Overall, our results imply that EPU is likely to yield a positive effect on climate change for a short time, but continue dependent will, in the long run, create an unhealthy environment. We suggest that the UK government should consider implementing an additional long-run policy that will supplement the effort of EPU. (C) 2020 Elsevier B.V. All rights reserved.
Delirium and COVID-19: a narrative review of emerging evidence

Delirium is a common condition affecting hospital inpatients, including those having surgery and on the intensive care unit. Delirium is also common in patients with COVID-19 in hospital settings, and the occurrence is higher than expected for similar infections. The short-term outcomes of those with COVID-19 delirium are similar to that of classical delirium and include increased length of stay and increased mortality. Management of delirium in COVID-19 in the context of a global pandemic is limited by the severity of the syndrome and compounded by the environmental constraints. Practical management includes effective screening, early identification and appropriate treatment aimed at minimising complications and timely escalation decisions. The pandemic has played out on the national stage and the effect of delirium on patients, relatives and healthcare workers remains unknown but evidence from the previous SARS outbreak suggests there may be long-lasting psychological damage.
Repeated treatments of Capan-1 cells with PARP1 and Chk1 inhibitors promote drug resistance, migration and invasion

PARP1 and Chk1 inhibitors have been shown to be synergistic in different cancer models in relatively short time treatment modes. However, the consequences of long-term/repeated treatments with the combinations in cancer models remain unclear. In this study, the synergistic cytotoxicity of their combinations in 8 tumor cell lines was confirmed in a 7-day exposure mode. Then, pancreatic Capan-1 cells were repeatedly treated with the PARP1 inhibitor olaparib, the Chk1 inhibitor rabusertib or their combination for 211-214 days, during which the changes in drug sensitivity were monitored at a 35-day interval. Unexpectedly, among the 3 treatment modes, the combination treatments resulted in the highest-grade resistance to Chk1 (~14.6 fold) and PARP1 (~420.2 fold) inhibitors, respectively. Consistently, G2/M arrest and apoptosis decreased significantly in the resulting resistant variants exposed to olaparib. All 3 resistant variants also unexpectedly obtained enhanced migratory and invasive capabilities. Moreover, the combination treatments resulted in increased migration and invasion than olaparib alone. The expression of 124 genes changed significantly in all the resistant variants. We further demonstrate that activating CXCL3-ERK1/2 signaling might contribute to the enhanced migratory capabilities rather than the acquired drug resistance. Our findings indicate that repeated treatments with the rabusertib/olaparib combination result in increased drug resistance and a more aggressive cell phenotype than those with either single agent, providing new clues for future clinical anticancer tests of PARP1 and Chk1 inhibitor combinations.
Biomass energy consumption and economic growth nexus in OECD countries: A panel analysis

This paper investigates the relationship between biomass energy consumption and economic growth for 26 OECD countries for 1980 to 2013 period. This study used panel unit root analyses, panel cointegration analyses, dynamic OLS analyses, fully modified OLS analyses and panel VECM Granger causality to examine the relationship. The results reveal the presence of long-run equilibrium relationship between the variables supporting the feedback hypothesis. As policy implication, OECD countries have to improve the biomass energy infrastructure as an important source of renewable energy to promote economic growth. (C) 2020 Elsevier Ltd. All rights reserved.
Changing from mandatory to optional genotyping results in higher acceptance of pharmacist-guided warfarin dosing

Aim: We evaluated the clinical acceptance and feasibility of a pharmacist-guided personalized consult service following its transition from a mandatory (mPGx) to optional (oPGx) CYP2C9/VKORC1/CYP4F2 genotyping for warfarin. Methods: A total of 1105 patients were included. Clinical acceptance and feasibility outcomes were analyzed using bivariate and multivariable analyses. Results: After transitioning to optional genotyping, genotype testing was still ordered in a large segment of the eligible population (52.1%). Physician acceptance of pharmacist-recommended doses improved from 83.9% (mPGx) to 86.6% (oPGx; OR: 1.3; 95% CI: 1.1-1.5; p = 0.01) with a shorter median genotype result turnaround time (oPGX: 23.6 h vs mPGX: 25.1 h; p < 0.01). Conclusion: Ordering of genotype testing and provider acceptance of dosing recommendations remained high after transitioning to optional genotyping.
Multi-scenario operation optimization model for park integrated energy system based on multi-energy demand response

Multi-energy demand response is an important means to achieve peak load shifting, and improve energy efficiency. It plays a significant role in promoting the sustainable development of park integrated energy system. In this context, we first constructed a mull-energy demand response model from the perspective of an elastic matrix. Second, we established performance evaluation indexes of the park integrated energy system based on economic and environmental factors, to match energy supply and demand. We then constructed an optimization model considering the unit output, energy balance, and other constraints to achieve optimal net profits, energy utilization efficiency, and degree of matching between load and output. Finally, we established multiple scenarios and used the multi-objective particle swarm optimization algorithm combined with fuzzy set theory for an example analysis. The results show that after redesigning the cooling, heating, and electricity prices, the multi-energy demand response model transfers the user load demand, without changing the total energy consumption. Compared with the traditional scenario, the energy utilization efficiency and net system profit increased by 2.30 % and $2,652.775, respectively, while the user expenditure decreased by $7,663.887, following implementation of the demand response model. This demonstrates win-win situations for the economy/environment and for the system/users.
Microemulsion-Confined Assembly of Magnetic Nanoclusters for pH/H2O2 Dual-Responsive T2-T1 Switchable MRI

In this work, a T2-T1 switchable superparamagnetic iron oxide nanoprobe with a pH/H2O2 dual response was obtained using a microemulsion method. This novel method for the controllable assembly of small iron clusters followed by their independent modification was reported, which could not be prepared by common synthetic methods. The size of the assembled nanoprobe was uniform and controllable, with a stable T2 magnetic resonance imaging (MRI) signal under a single condition. When the nanoprobe was exposed to the tumor environment, the higher H+ and H2O2 concentrations at the tumor site could dissociate the nanoprobe and redisperse into small iron clusters. When this occurred, the T2 MRI signal was converted into a T1 MRI signal, achieving specific detection of tumors by a pH/H2O2 dual-response T2-T1 MRI.
Vascular adhesion protein-1 and microvascular diabetic complications

Vascular adhesion protein-1 (VAP-1) is a bifunctional protein that has the ability to catalyze the deamination of primary amines and is involved in the production of hydrogen peroxide, aldehydes, and advanced glycation end products (AGEs). VAP-1 is usually stored in intracellular vesicles of endothelial cells, smooth muscles, and adipocytes. It is responsible for leukocyte transmigration and adhesion. Overexpression of VAP-1 exacerbates oxidative stress and modulates a variety of inflammatory mediators linked with diabetic complications. Numerous studies have suggested the association of increased insulin levels with serum VAP-1 (sVAP-1). Preclinical research evidence suggests the increased activity of sVAP-1 in type 1 and 2 diabetes. Scientific reports on VAP-1 inhibitors have shown a reduction in severity in diabetic animal models. VAP-1 is a potential target of a therapeutically effective line of treatment for diabetes and diabetic complications such as nephropathy and retinopathy. The primary focus of this review is the role of VAP-1 in diabetes and its associated microvascular complications.
Energy access during and post-COVID-19 pandemic in sub-Saharan countries: the case of Ethiopia

The global COVID-19 pandemic causes hundreds of thousands of deaths and has created a catastrophic economic and health crisis around the World. Transportation, manufacturing industries, business and people's movement came to almost a halt and sharp oil and gas prices reduction were observed. The impact of the pandemic for sub-Saharan countries like Ethiopia, which was already struggling with many economic and social welfare problems, is more evident than in other wealthy nations around the World. In Ethiopia, the general energy access rate is 44% and in healthcare facilities is only about 10%. Therefore, the response for the COVID-19 pandemic is challenging, since activities such as information sharing, communication with health centers, diagnosis and medical treatment require electricity access. This paper aims to assess the impact of the pandemic on energy access plans during and post-pandemic. The paper analyzed, the status of the current COVID-19 outbreak in Ethiopia, the energy access situation in health facilities, and the impacts of COVID-19 on energy access during and post-pandemic periods. Data related to the universal energy access plan of Ethiopia, the impact of energy access on healthcare services and the impact of the pandemic were reviewed for the assessment. The analysis indicates that the impact of the COVID-19 pandemic in Ethiopian healthcare facilities and on the overall universal energy access plan is immense and to minimize the global impact short and long-term policy responses are identified and urgently recommended. Furthermore, powering healthcare facilities with microgrids composed of solar panels and battery storage systems could be one cost-effective and sustainable solution for the speedy and effective response of the pandemic challenges.
Ranking European countries on the basis of their environmental and circular economy performance: A DEA application in MSW

The scope of this research is to present a more holistic approach on measuring countries' performance in managing and exploiting their Municipal Solid Waste (MSW). Specifically, we argue that relying solely on criteria like the recycling and/or the cyclical material use rate, can lead to an overestimation or underestimation of countries' true performance. That is because the level of waste generation is left unaccounted, despite the fact that low waste generation is an important environmental target, and so is the countries' true potential, as it is reflected by their economic and social progress. Instead, we measure the environmental and circular economy performance of 26 European Union countries by implementing Data Envelopment Analysis and tackle the aforementioned problem by using the generated quantity of MSW per capita and the three dimensions of the Social Progress Index as inputs and the recycling and/or the cyclical material use rate as outputs. We do so, using a basic framework and a framework that imposes common weights to enforce a full ranking of the countries. Our study shows large disparities among European countries, with respect to their performance. Interestingly though, the borders between Western and Eastern Europe have fallen, but not those between the north and the south: old EU members, such as Spain or France, perform significantly worst, both from an environmental and a circular economy perspective, than newer members, such as Slovenia or Poland. Finally, Belgium has been revealed as the best performer, both from an environmental and a cyclical economy perspective. (C) 2020 Elsevier Ltd. All rights reserved.
Synthesis of 2,24-Diene-12,13,15,16,34,35,37,38-octaphenyl[4.4]-triphenylparacyclophane

A new octaphenyl[4.4]triphenylparacyclophanediene was readily synthesized in six steps from p-xylene via the installment of bromine atoms, replacement with a vinyl group, carbonylative coupling, intermolecular followed by intramolecular double Grubbs olefin metathesis, Knoevenagel condensation, and Diels-Alder cycloaddition. The belt-shaped structure and trans-stereochemistry of the alkene moieties of the octaphenyl[4.4]triphenylparacyclophane and a synthetic intermediate, 2,21-dioxo-11,30-diene[3.4.3.4]paracyclophane, were determined by X-ray crystallography. The synthetic methodology leading to octaphenyl[4.4]triphenylparacyclophane is applicable for the synthesis of substituted triphenylparacyclophanes and possibly their corresponding bis-hexabenzocoronenylparacyclophanes via a Scholl-Mullen oxidative aryl-aryl coupling reaction.
B cell repertoire in patients with a novel BTK mutation: expanding the spectrum of atypical X-linked agammaglobulinemia

X-linked agammaglobulinemia (XLA) is caused by mutations in the Bruton tyrosine kinase) BTK) gene. Affected patients have severely reduced amounts of circulating B cells. Patients with atypical XLA may have residual circulating B cells, and there are few studies exploring these cells' repertoire. We aimed to study the B cell repertoire of a novel hypomorphic mutation in the BTK gene, using the next generation sequencing (NGS) technology. Clinical data was collected from our clinical records. Real-time PCR was used to determine KREC copies, and NGS was used to determine the immunoglobulin (Ig) heavy chain (IgH) repertoire diversity. Both patients had a relatively mild clinical and laboratory phenotype, residual BTK protein expression, and the same novel mutation in the BTK gene, c.1841 T > C, p. L614P. Signal-joint kappa-deleting recombination excision circles (sj-KREC) for both patients were completely absent reflecting lack of naïve B cells. The intron RSS-Kde coding joints (cj) were significantly reduced, reflecting residual replicating B cells. NGS displayed restricted IgH repertoire with highly uneven distribution of clones, especially for Pt2. We report a novel BTK mutation, c.1841 T > C (p. L614P) that is associated with a relatively mild phenotype. We conclude that the IgH repertoire in atypical XLA is restricted with highly uneven distribution of clones. This phenomenon may be explained by extremely reduced to non-existent levels of BTK in B cells. This report sheds further light on atypical cases of XLA.
Rabbit antithymocyte globulin dose and early subclinical and clinical rejections in kidney transplantation

Antithymocyte globulin (ATG) is a commonly used induction agent in kidney transplant recipients. However, the optimal dosing has not been well defined. Our protocol aims for a 5-6 mg/kg cumulative dose. It is unclear if a dose lower than 5 mg/kg is associated with more rejection. We performed a retrospective cohort study of patients who received a kidney transplant at our center between January 1, 2013 and December 31, 2016. Primary outcome was biopsy proven acute rejection (clinical and subclinical) in the first 6 months after kidney transplant. CMV viremia in high risk (D+/R-) recipients and BK viremia was compared as a secondary endpoint. Of the 543 patients, the Low Dose (LD) group (n = 56) received <5 mg/kg ATG and Regular Dose (RD) group (n = 487) received ≧5 mg/kg. Patients in RD were more sensitized (higher PRA and CPRA). LD received a dose of 4 ± 1.1 mg/kg ATG whereas RD received 5.6 ± .3 mg/kg ATG (P < .001). TCMR (Banff 1A or greater) was present in 34% of patients in LD versus 22% in RD (P = .04) (OR 2.1; 95%CI 1.12-3.81; P = .019). There was no difference in the incidence of CMV or BK viremia. ATG doses lower than 5 mg/kg may be associated with a heightened risk of rejection despite a low degree of sensitization.