ahmedabdelwahed/Medical_papers_title_and_abstract_NLP_dataset huggingface dataset:
Lakes and society: Mirrors to our past, present and future

Ultimately most things are connected. The lessons we learn from our arts, our literature and our science all reflect an understanding of the human lot. Ecology is concerned with systems that include humans but are dominated by other organisms. Sociology and economics are concerned with systems that include non-human organisms but are dominated by humans. Principles derived from a. study of the first, it is argued, can be applied to the second (for they are both manifestations of the same thing) in an attempt to explain why we are failing to move toward a sustainable existence. A range of ideas that have emerged from ecological studies, and particularly the alternative states model of shallow lakes, is used to illuminate the current problems of human societies in relation to the global environment.
Constructive feedforward ART clustering networks - Part I

Part I of this paper proposes a definition of the adaptive resonance theory (ART) class of constructive unsupervised on-line learning clustering networks. Class ART generalizes several well-known clustering models, e.g., ART 1, improved ART 1, adaptive Hamming net (AHN), and Fuzzy ART, which are optimized in terms of memory storage and/or computation time. Next, the symmetric Fuzzy ART (S-Fuzzy ART) network is presented as a possible improvement over Fuzzy ART. As a generalization of S-Fuzzy ART, the simplified adaptive resonance theory (SART) group of ART algorithms is defined. Gaussian ART (GART), which is found in the literature, is presented as one more instance of class SART. In Part 11 of this work, a novel SART network, called fully self-organizing SART (FOSART), is proposed and compared with Fuzzy ART, S-Fuzzy ART, GART and other well-known clustering algorithms. Results of our comparison may easily extend to the ARTMAP supervised learning framework.
Citizen Action as a Driving Force of Change. The Meninas of Canido, Art in the Street as an Urban Dynamizer

The austerity policies imposed by the government in the wake of the 2007 crisis have deteriorated the welfare state and limited neighborhood recovery. Considering the inability and inefficiency on the part of administrations to carry out improvement actions in neighborhoods, it is the neighborhood action itself that has carried out a series of resilient social innovations to reverse the dynamics. In this article, we will analyze the Canido neighborhood in Ferrol, a city in north-western Spain. Canido is traditional neighborhood that was experiencing a high degree of physical and social deterioration, until a cultural initiative called "Meninas of Canido," promoted by one of its artist neighbors, recovered its identity and revitalized it from a physical, social, and economic point of view. Currently, the Meninas of Canido has become one of the most important urban art events in Spain and has receives international recognition. The aim of this article is to evaluate the impact that this action has had in the neighborhood. For this, we conducted a series of semi-structured interviews with the local administration, neighborhood association, the precursors of this idea, merchants, and some residents in general, in order to perceive the reception and evolution of this action.
A 28 nm CMOS Triple-Latch Feed-Forward Dynamic Comparator With < 27 ps / 1 V and < 70 ps / 0.6 V Delay at 5 mV-Sensitivity

This article 1 presents a fully dynamic latched comparator with a high-gain three-stage configuration and an extra 3 parallel feed-forward path, able to achieve a delay of 26.8 ps and 4 a data rate of 13.5 Gb/s with less than 10(-12) BER for a 5 mVpp 5 differential input (Delta V-I) at 0.5 V common-mode (V-CM) and 1V 6 supply (V-DD). Additionally, the reduced-stacking cascaded triple7 latch arrangement enables a <70ps delay down to 0.6 V V-DD. 8 The comparator is analyzed and compared against two prior art 9 circuits by means of derived delay and noise expressions, serving 10 as design guidelines. The prototype comparator and its prior art 11 are fabricated in 28 nm bulk CMOS, with delay, input-referred 12 noise, energy/comparison, and area measurements highlighting 13 the benefits and trade-offs of the proposed solution.
THE ROLE OF DIET IN MULTIPLE SCLEROSIS

Multiple sclerosis (MS) is a disease of the central nervous system (CNS), characterized by chronic inflammation associated with autoimmune damage to myelin and axons leading to neurodegeneration. Although the etiology is not fully understood, some factors that increase the risk of disease have been identified. One of the key elements of multidisciplinary approach to the management of MS is a properly balanced diet, e.g. Swank diet. Its main assumption is to reduce the supply of animal fats in favor of fats of plant origin, which contain polyunsaturated fatty acids omega-3. One of the factors influencing the course of the disease is vitamin D deficiency. In 80-90% it is synthesized by exposure to the sun, while the other 10-20% may be supplied with ingested food. Although elevated plasma homocysteine levels have been demonstrated in MS patients, there is no need to modify the supply of B vitamins. Further studies are necessary to show the correlation between the supply of B vitamins and the course of the disease. Due to the antioxidant effect, it is recommended to include products that are sources of vitamin A, E and C, glutathione, coenzyme Q10. It is also beneficial to include compounds from the polyphenol group: quercetin, resveratrol and curcumin. Through proper nutrition model it is also possible to reduce side effects of applied medications, such as constipation, what improves patients' quality of life. Diet therapy is a key element supporting pharmacotherapy in patients with multiple sclerosis.
Child abuse linked to faith or belief: working towards recognition in practice

Child abuse linked to faith or belief (CALFB) is a worldwide issue that is linked to serious short-term and long-term consequences and even death. Children affected by CALFB may have undergone multiple abuses - such as ritual starvation, beatings, burns, stabbings and drowning - prompting concern in hospitals, schools and communities, including in emergency and primary care settings. Nurses have an important role in safeguarding children and young people, and their role in identifying and responding to CALFB is often challenging. This article uses a 'competemility' (cultural competence and cultural humility) approach to raise awareness of CALFB reporting and investigations in the UK. It examines medical evidence and psychosocial indicators of this form of abuse and explains the metaphorical language and thoughts associated with reported beliefs. The article aims to support nurses to be culturally sensitive to CALFB and to explore how they can contribute to preserve the safety of children in familial and community settings.
Energy harvesting on road pavements: state of the art

With the growing need for alternative energy sources, research into energy harvesting technologies has increased considerably in recent years. The particular case of energy harvesting on road pavements is a very recent area of research. This paper deals with the development of energy harvesting technologies for road pavements, identifies the technologies that are being studied and developed, examines how such technologies can be divided into different classes and gives a technical analysis and comparison of those technologies, using the results achieved with prototypes.
The impact of flooding on food security across Africa

Recent record rainfall and flood events have prompted increased attention to flood impacts on human systems. Information regarding flood effects on food security is of particular importance for humanitarian organizations and is especially valuable across Africa's rural areas that contribute to regional food supplies. We quantitatively evaluate where and to what extent flooding impacts food security across Africa, using a Granger causality analysis and panel modeling approaches. Within our modeled areas, we find that ∼12% of the people that experienced food insecurity from 2009 to 2020 had their food security status affected by flooding. Furthermore, flooding and its associated meteorological conditions can simultaneously degrade food security locally while enhancing it at regional spatial scales, leading to large variations in overall food security outcomes. Dedicated data collection at the intersection of flood events and associated food security measures across different spatial and temporal scales are required to better characterize the extent of flood impact and inform preparedness, response, and recovery needs.
Prevalence of HIV-1 infection among foreign applicant to residency in Shanghai, China, 2005-2016

Shanghai is one of the largest cities in China and has the highest proportion of inbound travelers in the world. The HIV (human immunodeficiency virus) infection status of this population can reflect the global HIV epidemic trend to a certain extent. Therefore, we conducted a retrospective epidemic survey to clarify the prevalence and characteristics of HIV-1 infection among inbound travelers applying for Shanghai residency. The retrospective cohort analysis included a total of 50,830 inbound tourists/travelers who applied for Shanghai residency from 2005 to 2016. HIV-1 infection rates were determined based on HIV-1 antibody testing. Among all the recruited inbound travelers, 245 were HIV-1 positive, with an infection rate of 0.48%. The detection rate of HIV in males was significantly higher than in females (χ2 = 62.584, P < 0.0001). Those aged 18-30 years, 31-40 years, and >40 years accounted for 34.3%, 39.6%, and 26.1% of the infected population, respectively. Although the annual detection rates were different, the trend analysis results showed no increase in HIV-1 prevalence rates among the sampling years (Cochran-Armitage Z = 2.543, P = 0.111). Proportions of individuals infected through homosexual transmission increased over the study period (Cochran-Armitage Z = 5.41, P < 0.001), while the proportion infected through heterosexual declined over time (Cochran-Armitage Z = 3.38, P = 0.001). The rate and characteristics of HIV-1 infection among foreign applicants for residency in Shanghai were identified in the study. The results provide the necessary epidemiological data for monitoring the HIV-1 epidemic among international entry travelers and contribute to establishing relevant policies and regulations for HIV control and prevention.
The diagnosis, classification, and treatment of sarcoma in this era of artificial intelligence and immunotherapy

Soft-tissue sarcomas (STS) represent a group of rare and heterogeneous tumors associated with several challenges, including incorrect or late diagnosis, the lack of clinical expertise, and limited therapeutic options. Digital pathology and radiomics represent transformative technologies that appear promising for improving the accuracy of cancer diagnosis, characterization and monitoring. Herein, we review the potential role of the application of digital pathology and radiomics in managing patients with STS. We have particularly described the main results and the limits of the studies using radiomics to refine diagnosis or predict the outcome of patients with soft-tissue sarcomas. We also discussed the current limitation of implementing radiomics in routine settings. Standard management approaches for STS have not improved since the early 1970s. Immunotherapy has revolutionized cancer treatment; nonetheless, immuno-oncology agents have not yet been approved for patients with STS. However, several lines of evidence indicate that immunotherapy may represent an efficient therapeutic strategy for this group of diseases. Thus, we emphasized the remarkable potential of immunotherapy in sarcoma treatment by focusing on recent data regarding the immune landscape of these tumors. We have particularly emphasized the fact that the development of immunotherapy for sarcomas is not an aspect of histology (except for alveolar soft-part sarcoma) but rather that of the tumor microenvironment. Future studies investigating immunotherapy strategies in sarcomas should incorporate at least the presence of tertiary lymphoid structures as a stratification factor in their design, besides including a strong translational program that will allow for a better understanding of the determinants involved in sensitivity and treatment resistance to immune-oncology agents.
Value of SGLT-2 inhibitors in the treatment of chronic kidney disease : Clinical and practical implications

Chronic kidney disease (CKD) drastically increases the risk for cardiovascular morbidity and mortality and its worldwide prevalence is still rising. Effective treatment slows CKD progression, prevents development of end-stage kidney disease and cardiovascular disease thereby prolonging survival of patients. Recently, several large-scale studies with sodium-glucose cotransport‑2 inhibitors (SGLT-2i) have demonstrated profound nephroprotective and cardioprotective properties in patients with type 2 diabetes mellitus with both CKD and heart failure. Recently, the dapagliflozin and prevention of adverse outcomes in chronic kidney disease (DAPA-CKD) trial demonstrated that the selective SGLT-2i dapagliflozin reduced the hazard ratio for a composite renal and cardiovascular death endpoint in patients with CKD with or without type 2 diabetes. Furthermore, dapagliflozin exerted strong nephroprotection in CKD patients with diverse etiologies like IgA nephropathy. Furthermore, other promising CKD trials such as with empagliflozin are underway. Hence, individualized treatment with SGLT2i represents a promising therapeutic option for patients with both diabetic and non-diabetic CKD. Here we summarize the current knowledge on the treatment with SGLT-2i in CKD patients underscoring a strong rationale for SGLT2 inhibition to be incorporated into standard of care for most CKD patients also with non-diabetic kidney disease. Finally, we aim to translate the current evidence into recommendations for the clinical practice in the management of patients with CKD.
Defined Human Leukemic CD34+ Liquid Cultures to Study HDAC/Transcriptional Repressor Complexes

Defined human primary cell model systems with growth dependence on oncogenes are highly requested to investigate tumor pathogenesis and to validate pharmacological inhibitors that specifically target oncoproteins and their executing protein complex partners. In acute myeloid leukemia (AML), transcription factors such as RUNX1 and MLL1, which are important for normal blood cell development, frequently harbor mutations including chromosomal translocations with other coding genes, resulting in tumor-promoting gain-of-function fusion proteins. These oncoproteins completely modify transcriptional programs, thereby inducing malignant cell phenotypes. A common theme of the chimeric gene products is their physical interaction with a variety of chromatin-modifying effector molecules, including histone acetyltransferases (HATs) and histone deacetylases (HDACs). These aberrant multiprotein machineries disturb gene expression and promote malignant cell growth. In this chapter, we briefly summarize the current understanding regarding AML-associated oncogene-driven human CD34+ blood progenitor cell expansion in ex vivo liquid cultures. We provide a step-by-step protocol to establish oncogene-induced human CD34+ blood progenitor cell cultures suitable to analyze the impact of transcriptional repressor/HDAC activity in these human AML cell models.
Plasmonic-Thermoelectric Nanotweezers for Immersive SERS Mapping

Surface-enhanced Raman spectroscopy (SERS) technology usually uses metallic nanoparticles to enhance Raman scattering signals, thereby significantly adding to molecule-level recognition and detection. However, realization of nanometer-scaled SERS imaging in liquid environments is extremely difficult due to the requirements of both precise scanning of single metallic nanoparticle and high enhancement field and thus has never been achieved before. To overcome this obstacle, we demonstrate an immersive nanometer-scaled SERS mapping technology, based on dynamic scanning of a single metallic nanoparticle with a plasmonic-thermoelectric nanotweezers system. The technology offers greater stability in the plasmonic trapping of gold nanoparticles at relative low power, as well as generating higher electric fields in the gap region. Through its dynamics, two-dimensional nanometer-scaled SERS imaging is achieved successfully. In regard to in liquid environments, this technology provides a mapping method for label-free imaging of ultrathin materials, structures, and biological samples.
Characteristics of a new carotenoid cleavage dioxygenase NtCCD10 derived from Nicotiana tabacum

A new carotenoid cleavage dioxygenase NtCCD10 from tobacco was characterized. There is some difference between NtCCD10 and CCD1 in structure. NtCCD10 can cleave the C5-C6 (C5'-C6') and C9-C10 (C9'-C10') double bonds of carotenoids and has high catalytic activity. Carotenoid cleavage dioxygenases (CCDs) cleave carotenoids to produce a variety of apocarotenoids, which have important biological functions for organisms in nature. There are eleven CCDs subfamilies in the plant kingdom, many of which have been extensively characterized in their functions. However, as a newly classified subfamily, the function of CCD10 has rarely been studied. In this work, the function of an NtCCD10 gene from dicotyledonous Nicotiana tabacum was cloned and characterized, and its phylogeny, molecular structural modeling and protein structure were also systematically analyzed. Like other CCDs, NtCCD10 also possesses a seven bladed β-propeller with Fe2+ cofactor in its center constituting the active site of the enzyme. The Fe2+ is also coordinated bonding with four conserved histidine residues. Meanwhile, NtCCD10 also has many unique features, such as its α1 and α3 helixes are not anti-parallel, a special β-sheet and a longer access tunnel for substrates. When expressed in engineered Escherichia coli (producing phytoene, lycopene, β-carotene, and zeaxanthin) and Saccharomyces cerevisiae (producing β-carotene), NtCCD10 could symmetrically cleave phytoene and β-carotene at the C9-C10 and C9'-C10' positions to produce geranylacetone and β-ionone, respectively. In addition, NtCCD10 could also cleave the C5-C6 and C5'-C6' double bonds of lycopene to generate 6-methyl-5-heptene-2-one (MHO). NtCCD10 has higher catalytic activity than PhCCD1 in yeast, which provides a good candidate CCD for biosynthesis of β-ionone and has potential applications in biotechnological industry. This study identified the taxonomic position and catalytic activity of the first NtCCD10 in dicotyledonous plants. This will provide a reference for the discovery and functional identification of CCD10 enzymes in dicotyledons.
An analytical process-based approach to predicting breach width in levees constructed from dilatant soils

An accurate prediction of the breach widening rate after the onset of a levee failure is essential for flood risk assessments. Current state-of-the-art analytical breach growth relations are empirical in nature. The large variety in loading conditions, levee design, and levee construction material, combined with the limited amount of accurate measurements of breach growth, make the development of accurate empirical breach growth relations challenging. In this paper, a process-based breach widening relation is presented for levees constructed of dilatant soils. The process-based relation is derived from the weir flow equation and a process-based erosion equation. The breach widening relation can account for the effects of variations in soil parameters. For those cases for which soil parameters are unknown, a calibrated catch-all-coefficient is provided. The relation is benchmarked against the state-of-the-art empirical breach growth relation used in the Netherlands and validated against data on historical levee failures and experimental data.
Experiment and calculation of deposition velocity of suspended particles in storm drainage

Deposition particles can lead to blockage, odor, and corrosion of pipes, and the deposition process of suspended particles is particularly complicated. In order to quantify the deposition process of suspended particles and mastered the critical conditions for the deposition in storm drainage, the process was simulated experimentally, and the deposition states of suspended particles under the different roughness of pipe wall, particle size, and density were analyzed. Two mathematical models of deposition critical velocity and easy deposition velocity were established. Results showed that with the increase of particle size and density, the gravity of particles increased and deposition was more likely to occur. In the rough pipeline, the kinetic energy consumption of water flow increased, the ability to carry particles was weakened, and the deposition rate would increase accordingly. The higher the flow velocity, the lower the deposition rate. The deposition states of particles in the pipeline could be divided into three types according to the deposition rates: "no deposition," "minor deposition," and "bulk deposition." Verification showed that the difference rates between the calculated values and measured values of the deposition critical velocity ranged from - 3.23 to 2.86%, and the difference rates of the easy deposition velocity were - 4.14-4.72%, showing good consistency.
Synthesis, Processing, and Function of N-Glycans in N-Glycoproteins

Many membrane-resident and secreted proteins, including growth factors and their receptors are N-glycosylated. The initial N-glycan structure is synthesized in the endoplasmic reticulum (ER) as a branched structure on a lipid anchor (dolicholpyrophosphate) and then co-translationally, "en bloc" transferred and linked via N-acetylglucosamine to asparagine within a specific N-glycosylation acceptor sequence of the nascent recipient protein. In the ER and then the Golgi apparatus, the N-linked glycan structure is modified by hydrolytic removal of sugar residues ("trimming") followed by re-glycosylation with additional sugar residues ("processing") such as galactose, fucose or sialic acid to form complex N-glycoproteins. While the sequence of the reactions leading to biosynthesis, "en bloc" transfer and processing of N-glycans is well investigated, it is still not completely understood how N-glycans affect the biological fate and function of N-glycoproteins. This review will discuss the biology of N-glycoprotein synthesis, processing and function with specific reference to the physiology and pathophysiology of the immune and nervous system, as well as infectious diseases such as Covid-19.
RTHS: A Low-Cost High-Performance Real-Time Hardware Sorter, Using a Multidimensional Sorting Algorithm

This paper proposes a novel hardware-based multi-dimensional sorting algorithm and its respective architecture, called real-time hardware sorter (RTHS), for emerging data intensive processing applications where performance and resource conservation are serious concerns. The basic idea behind RTHS is to reduce the hardware complexity of parallel hardware sorting architectures (PHSAs) through a high-performance scalable matrix-based sorting method. The proposed method can also be used for implementing Min/Max queues or finding the largest/smallest records exclusively in the big data application. Implementing the RTHS design on a Virtex-7 field-programmable gate array (FPGA) reveals that the number of lookup tables (LUTs) of the proposed method has decreased by 66.3% and 87.3% compared to the conventional Bitonic sorting network (CBSN) and the state-of-the-art PHSA, respectively. In addition, the number of required registers for the proposed method has decreased by 94.8% compared to the state-of-the-art PHSA.