ahmedabdelwahed/Medical_papers_title_and_abstract_NLP_dataset huggingface dataset:
Intratympanic steroid treatment can reduce ROS and immune response in human perilymph investigated by in-depth proteome analysis

Intratympanic (IT) steroid treatment is one of the most widely used and effective treatments for inner ear disorders such as sudden sensorineural hearing loss (SNHL). However, a clear mechanism of IT steroids in inner ear recovery has not yet been revealed. Therefore, we investigated proteome changes in extracted human perilymph after steroid treatment. In this study, we applied a tandem mass spectrometry (MS/MS)-based proteomics approach to discover global proteome changes by comparing human perilymph after steroid treatment with non-treated perilymph group. Using liquid chromatography-MS/MS analysis, we selected 156 differentially expressed proteins (DEPs) that were statistically significant according to Student's t-test. Functional annotation analysis showed that upregulated proteins after steroid treatment are related to apoptosis signaling, as well as reactive oxygen species (ROS) and immune responses. The protein-protein interaction (PPI) clusters the proteins associated with these processes and attempts to observe signaling circuitry, which mediates cellular response after IT steroid treatments. Moreover, we also considered the interactome analysis of DEPs and observed that those with high interaction scores were categorized as having equivalent molecular functions (MFs). Collectively, we suggest that DEPs and interacting proteins in human perilymph after steroid treatment would inhibit the apoptotic and adaptive immune processes that may lead to anti-inflammatory effects.
RegionSeeker: Automatically Identifying and Selecting Accelerators From Application Source Code

Embedded systems present stringent and often conflicting requirements. On the one side, the need for high performance within a tight energy budget favors inflexible Application Specific Integrated Circuit (ASIC) implementations; on the other side, a short time-to-market demands programmability. Hybrid architectures such as special-purpose customized processors represent an attractive solution, as they arc programmable by software, but use dedicated hardware to accelerate parts of the computation. In such a scenario, the capability of automatically identifying the computation parts to he realized in hardware is highly desirable, in order to reduce design time and effort. This paper aims at advancing the state-of-the-art in this field. We recognize that subgraphs of control flow graphs having a single input control point and a single output control point, that we call regions, are good targets for the synthesis of application specific hardware accelerators. We therefore provide a method to identify them and an LINM-based toolchain (named RegionSeeker) that, analyzing a software application, automatically selects its most profitable regions given an area constraint. Experimental evidence shows that the accelerators identified by RegionSeeker provide a speedup of up to 4.6x and, on average, approximately 30% higher speedup is achieved compared to state-of-the-art identification techniques.
Sustainable Design Masters: Increasing the Sustainability Literacy of Designers

This paper examines student learning in the Master of Arts in Sustainable Design course at Kingston School of Art, Kingston University London. It considers what designers learn, how they learn and where they learn, in a postgraduate course that seeks to enable them to direct their practice towards sustainability by increasing their sustainability literacy. The paper reviews the learning experiences of students, and the curriculum structures and approaches used to serve those experiences. The story of the course is told here by the course leader of ten years, using student outputs to illustrate the argument made for a sustainable design pedagogy. The key principles of this pedagogy are (1) sustainability is a social, not just an environmental, agenda; (2) sustainability presents us with 'wicked problems', which have no right or wrong answers; (3) sustainability-directed design practice arises from the sustainability literacy of the designer; (4) sustainability derives from mindsets and worldviews, not just methods and materials; and (5) sustainability is an emergent property of systems, not a quality of products. This combination has generated a distinctive model of postgraduate sustainable design education, which seeks to equip students with a 'mastery' of how to put into practice their own visions of sustainable design.
Phosphosites of the yeast centrosome component Spc110 contribute to cell cycle progression and mitotic exit

Spc110 is an essential component of the spindle pole body (SPB), the yeast equivalent of the centrosome, that recruits the γ-tubulin complex to the nuclear side of the SPB to produce the microtubules that form the mitotic spindle. Here, we identified phosphosites S11 and S36 in maternally originated Spc110 and explored their functions in vivo. Yeast expressing non-phosphorylatable Spc110S11A had a distinct spindle phenotype characterised by higher levels of α-tubulin, which was frequently asymmetrically distributed between the two SPBs. Furthermore, expression of the double mutant Spc110S11AS36A had a delayed cell cycle progression. Specifically, the final steps of mitosis were delayed in Spc110S11AS36A cells, including expression and degradation of the mitotic cyclin Clb2, disassembling the mitotic spindle and re-localizing Cdc14 to the nucleoli, resulting in late mitotic exit and entry in G1. Thus, we propose that Spc110 phosphorylation at S11 and S36 is required to regulate timely cell cycle progression in budding yeast. This article has an associated First Person interview with the first author of the paper.
Comparison of the Literacy Level on Major Environmental Issues of the GCE (A/L) Students of Different Disciplines in Kandy District, Sri Lanka

The study aims to examine the environmental literacy level of G.C.E A/L students (comparable to British Advanced Level) in the Kandy District, Sri Lanka, and to evaluate environment modules embedded into the curriculum. Furthermore, we find the relationships between environmental literacy level and socioeconomic and discipline levels. A survey with a sample of 300 students was selected randomly from four different disciplines, with 25 students in each subject (biological science, mathematics, arts, and commerce) from three different types of schools (Public, Private, and International). A piloted, self-administered, and structured questionnaire with 44 items under six sections (personal background, environmental issues, attitudes, behavior, suggestion, and mitigation) was randomly distributed among the study sample. Results showed that most respondents reside in an urban area, the education level of parents was positioned in the G.C.E. (A/L) category, and the monthly total family income was more than SLR 90,000.00. Overall, the environmental literacy (EL) was similar among students of three different types of schools. The type of permanent residence, discipline, and educational background of parents were recognized as determining factors of EL levels (p < 0.05). The environmental literacy knowledge of biological science students was the highest (44%), followed by mathematics (36%), art (32%), and commerce (28%). Furthermore, the EL of the biology discipline was significantly different from commerce (18%) and art (14%) students. Students acquired environmental knowledge from television and radio (44%), internet (22%), school (27%), and parents (7%). The A/L Curriculum evaluation results proved that much less environment-related components were included in the commerce, art, and mathematics subjects. Of the disciplines, geography (35%) and biological science (11%) included a higher amount of EL knowledge, comparatively. Students suggested that recycling/ reuse of waste conserves natural resources, the green building concept, and the use of public transportation to conserve the environment. This study recommends that environmental concepts should be integrated with formal G.C.E A/L syllabus with activity learning, especially for non-science disciplines, and that environment-related television and radio programs should be enhanced.
Street Art Participation in Increasing Investments in the City Center of Bucharest, a Paradox or Not?

This article analyses street art's contribution to the current economic life in the city center of an Eastern European capital, Bucharest. The development of socio-economic activities in the Romanian capital has been strongly influenced in the last 30 years by a complex of effects generated by the transition to the capitalist economy in the early 1990s, the impact of globalization, and recently the COVID-19 pandemic. This study focuses on the investigation of those areas that through street art came to know processes of urban regeneration. By applying semi-structured interviews to providers of alternative guided tours, but also questionnaires among the population that is familiar with this subculture, including an organization of urban regeneration through street art, an important number of economically new spaces, next to reinvented ones, have been investigated. In these areas, street art ends up by supporting activities from hospitality, cultural, and creative industries, changing for the better the perspectives of economic and cultural development, along with the attractiveness of the Bucharest city center. Street art proves to be an important tool in the regeneration process bringing positive effects when involving active cooperation between the public and the private sectors.
Purified exosome product enhances chondrocyte survival and regeneration by modulating inflammation and promoting chondrogenesis

Aim: This study was to detect the effects of purified exosome product (PEP) on C28/I2 cells and chondrocytes derived from osteoarthritis patients. Materials & methods: Cell viability and apoptosis assays were used to detect the effect of PEP on cells. qRT-PCR and cell fluorescence assays were used to investigate the potential mechanism of PEP on cell chondrogenesis. Results: PEP was internalized by cells at a fast rate and enhanced cellular proliferation and migration while attenuating apoptosis. These findings reflect the fact that PEP can increase the expression of PCNA and reduce the expression of CASP3/7/9 and BAX. Conclusion: This study suggests an innovative strategy for chondrogenesis that could be applied to osteoarthritis repair in the future.
Emerging and Versatile Platforms of Metal-Ion-Doped Carbon Dots for Biosensing, Bioimaging, and Disease Therapy

Metal ions possess abundant electrons and unoccupied orbitals, as well as large atomic radii, whose doping into carbon dots (CDs) is a facile strategy to endow CDs with additional physicochemical characteristics. After being doped with metal ions, CDs reveal obvious changes in their optical, electronic, and magnetic properties by adjustments to their electron density distribution and the energy gaps, leading them to be promising and competitive candidates as labeling probes, imaging agents, catalysts, nanodrugs, and so on. In this review, we summarize the fabrication methods of metal-ion-doped CDs (M-CDs), and highlight their biological applications including biosensing, bioimaging, tumor therapy, and anti-microbial treatment. Finally, the challenging future perspectives of M-CDs are analyzed. We hope this review will provide inspiration for further development of M-CDs in various biological aspects, and help readers who are interested in M-CDs and their biological applications.
The small heat shock protein, HSP30, is associated with aggresome-like inclusion bodies in proteasomal inhibitor-, arsenite-, and cadmium-treated Xenopus kidney cells

In the present study, treatment of Xenopus laevis A6 kidney epithelial cells with the proteasomal inhibitor, MG132, or the environmental toxicants, sodium arsenite or cadmium chloride, induced the accumulation of the small heat shock protein, HSP30, in total and in both soluble and insoluble protein fractions. Immunocytochemical analysis revealed the presence of relatively large HSP30 structures primarily in the perinuclear region of the cytoplasm. All three of the stressors promoted the formation of aggresome-like inclusion bodies as determined by immunocytochemistry and laser scanning confocal microscopy using a ProteoStat aggresome dye and additional aggresomal markers, namely, anti-γ-tubulin and anti-vimentin antibodies. Further analysis revealed that HSP30 co-localized with these aggresome-like inclusion bodies. In most cells, HSP30 was found to envelope or occur within these structures. Finally, we show that treatment of cells with withaferin A, a steroidal lactone with anti-inflammatory, anti-tumor, and proteasomal inhibitor properties, also induced HSP30 accumulation that co-localized with aggresome-like inclusion bodies. It is possible that proteasomal inhibitor or metal/metalloid-induced formation of aggresome-like inclusion bodies may sequester toxic protein aggregates until they can be degraded. While the role of HSP30 in these aggresome-like structures is not known, it is possible that they may be involved in various aspects of aggresome-like inclusion body formation or transport.
Polymeric stabilizers for protection of soil and ground against wind and water erosion

The article is devoted to the design, development and application of a new generation of binders for various dispersed systems, including soil, ground, sand, waste rock and others. The binders are formed by interaction of oppositely charged polyelectrolytes, both chemically stable and (bio)degradable. The fundamental aspects of interpolyelectrolyte reactions are discussed; the IPC structure and properties of the resulting interpolyelectrolyte complexes (IPCs) allow considering them as unique and universal binders. Numerous results of laboratory experiments and field trials of the IPC formulations are presented. In particular, large-scale tests have been done in the Chernobyl accident zone where the IPC binders were shown to be effective means to suppress water and wind erosion thereby preventing a spread of radioactive particles (radionuclides) from contaminated sites. Ecologically friendly IPC compositions are described, including those based on commercially available polymers; prospects for improving their efficiency and extending the range of their possible use are discussed.
Contralaterally Enhanced Networks for Thoracic Disease Detection

Identifying and locating diseases in chest X-rays are very challenging, due to the low visual contrast between normal and abnormal regions, and distortions caused by other overlapping tissues. An interesting phenomenon is that there exist many similar structures in the left and right parts of the chest, such as ribs, lung fields and bronchial tubes. This kind of similarities can be used to identify diseases in chest X-rays, according to the experience of broad-certificated radiologists. Aimed at improving the performance of existing detection methods, we propose a deep end-to-end module to exploit the contralateral context information for enhancing feature representations of disease proposals. First of all, under the guidance of the spine line, the spatial transformer network is employed to extract local contralateral patches, which can provide valuable context information for disease proposals. Then, we build up a specific module, based on both additive and subtractive operations, to fuse the features of the disease proposal and the contralateral patch. Our method can be integrated into both fully and weakly supervised disease detection frameworks. It achieves 33.17 AP50 on a carefully annotated private chest X-ray dataset which contains 31,000 images. Experiments on the NIH chest X-ray dataset indicate that our method achieves state-of-the-art performance in weakly-supervised disease localization.
Biodeterioration of Concrete Sewer Pipes: State of the Art and Research Needs

Biodeterioration of concrete sewers is a common problem that results in concrete disintegration and significant damage. Two stages are normally identifiable in the process: an initiation stage, during which the concrete pore water pH is reduced from an initial value of over 12 to a value of about 9 by ingress of hydrogen sulfide gas and carbon dioxide (carbonation) and subsequent reaction with the hydrated cement paste; and a second stage, active biodeterioration, during which microorganisms excrete sulfuric acid that attacks the hydrated cement paste (HCP). Various national codes and standards provide some guidance to mitigate this problem. Sulfur-oxidizing microorganisms growing on the sewer walls have been isolated as the main culprit, but other phenomena come into play before biodeterioration occurs. Steady-state biodeterioration rates of 3 mm/year have been proposed in the literature. A detailed literature review was conducted to evaluate the various aspects of concrete biodeterioration and determine further research needs. This state-of-the-art report summarizes the deterioration mechanisms involved in biodeterioration of concrete sewers and the work necessary to complete the modeling of this phenomenon. A conceptual model of the processes is presented. (C) 2011 American Society of Civil Engineers.
Telling impressions: Breuil's 1929 visit to rock art and Stone Age sites near Kimberley, South Africa

Stone Age and rock art sites that Breuil would visit near Kimberley, South Africa, during and after the 1929 conference of the British and South African Associations for the Advancement of Science, were amongst the first he would see in Africa. Breuil's published observations and an autobiographical account afford a keyhole view on his initial thoughts with hints of ways these would develop, alongside and in relation to the perspectives of contemporaries. The roles of Breuil's field and editorial helpers are highlighted for the insights they provide on his modus operandi. Pratt's concept of 'discursive polyphony' is advanced as a useful frame for understanding the range of shifting perspectives that are entangled in these histories. Opportunities are sought, in discussion, to reflect on the Breuil legacy in light of subsequent work in the region.
Haploidentical transplant for paediatric patients with severe thalassaemia using post-transplant cyclophosphamide and methotrexate: A prospectively registered multicentre trial from the Bone Marrow Failure Working Group of Hunan Province, China

Haploidentical transplantation strategies for patients with transfusion-dependent thalassaemia (TD-TM) remain to be investigated. In this study, 54 paediatric patients with TD-TM were treated with a novel approach using post-transplant cyclophosphamide (PTCy) and low-dose methotrexate (LD-MTX), following a myeloablative regimen. The incidence of neutrophil and platelet engraftment was 96.3% ± 2.6% and 94.4% ± 3.1% respectively. The cumulative incidence of grades II-III acute graft-versus-host disease (GVHD) was 13.8% ± 4.8% at 100 days. At three years, the cumulative incidence of chronic GVHD was 28.5% ± 8.5%. With a median follow-up of 520 days (132-1325 days), the overall survival (OS) and event-free survival (EFS) were 98.1% ± 1.8% and 90.7% ± 3.9% respectively. Compared with the low-dose cyclophosphamide (CTX) conditioning regimen (120 mg/kg), the high-CTX regimen (200 mg/kg) achieved a higher incidence of stable engraftment (100% vs 66.7% ± 15.7%, p = 0.003), a comparable incidence of grades II-III acute GVHD, a lower incidence of chronic GVHD (20.2% ± 8.3% vs 66.6% ± 19.2%, p = 0.011), and better overall survival (100% vs 88.9% ± 10.5%, p = 0.025) as well as EFS (95.6% ± 3.1% vs 66.7% ± 15.7%, p = 0.008). Our results using unmanipulated haploidentical grafts and PTCy with LD-MTX in TD-TM are encouraging. (chictr.org.cn ChiCTR1800017969).
A comparative economic analysis of torrefied pellet production based on state-of-the-art pellets

Torrefied pellets have fuel properties superior to those of conventional wood pellets and potentially allow greater rates of co-firing and thus larger reductions in net CO2 emissions. Despite the growing amount of scientific output on torrefaction, the economic feasibility of torrefied pellet production is still a topic of considerable uncertainty. This is an obstacle for decision makers looking to implement sustainable energy policies. This paper compares the economics of torrefied pellets to conventional wood pellets. Working backwards from demonstrated pellet properties, this work attempts to answer the following question: Based on state-of-the-art torrefied pellets, what would be the maximum capital investment required for a torrefied pellet plant so that production is economically viable? Herein, the production costs of torrefied pellets are calculated based on inputs in production. The market value of the produced pellets is estimated and a cash-flow analysis is carried out. Three economic indicators are calculated and compared for a torrefied and conventional pellet production scenario. A sensitivity analysis is carried out for selected process inputs and the cost of CO2 through co-firing pellets is estimated. The results indicate that state-of-the-art torrefied pellet production cannot compete with conventional pellets even with transatlantic product transport distances. A high capital investment cost and a low heating value are the main barriers to economic feasibility of state-of-the-art torrefied pellets. (C) 2016 Elsevier Ltd. All rights reserved.
Socio-technical energy scenarios: state-of-the-art and CIB-based approaches

Energy conversion is a major source of greenhouse gas (GHG) emissions, and energy transition scenarios are a key tool for gaining a greater understanding of the possible pathways toward climate protection. There is consensus in energy research that political and societal framework conditions will play a pivotal role in shaping energy transitions. In energy scenario construction, this perspective is increasingly acknowledged through the approach of informing model-based energy analysis with storylines about societal futures, an exercise we call "socio-technical energy scenario construction" in this article. However, there is a dispute about how to construct the storylines in a traceable, consistent, comprehensive, and reproducible way. This study aims to support energy researchers considering the use of the concept of socio-technical scenarios in two ways: first, we provide a state-of-the-art analysis of socio-technical energy scenario construction by comparing 16 studies with respect to five categories. Second, we address the dispute regarding storyline construction in energy research and examine 13 reports using the Cross-Impact Balances method. We collated researcher statements on the strengths and challenges of this method and identified seven categories of promises and challenges each.