ahmedabdelwahed/Medical_papers_title_and_abstract_NLP_dataset huggingface dataset:
Technical, economic and environmental assessement of bioethanol biorefinery from waste biomass

This study presents a sequential three-steps methodology for the technical, economic and environmental assessment (TEEA) of bioethanol production from waste biomass. In EU the most abundant waste biomasses produced in 2018 could be ascribed to three main categories: lignocellulosic (329.41 Mt), starch (160 Mt) and sugar-based (58.56 Mt). The technical assessment compiled an inventory of the waste biomasses and subsequently designed their biological conversion into ethanol through integrated biorefinery processes by means of material flow analysis (MFA); the economic assessment was aimed at the definition of the cut-off size of the biorefinery plant necessary to achieve profitability; the environmental assessment was based on Life Cycle Analysis (LCA) and energy balance (i.e. energy input consumption). For each of the three waste biomass categories, at least one that was significant as available amount and representative in terms of physico-chemical characteristics, was evaluated: sugarcane for sugar-based, potatoes for starch-based and rice straw, cattle manure and organic fraction of municipal solid waste (OFMSW) for lignocellulosic biomasses. The technical assessment of the biorefinery routes lead to the following yields (kg of bioethanol per kg of biomass): 0.16, 0.17, 0.22, 0.19 and 0.14 respectively. The economic profitability was reached by all biorefineries and Net Present Value (MV) were: 0.85 for sugarcane, 0.11 for potatoes, 0.09 for rice straw, 0.11 for cattle manure and 0.39 for OFMSW. From the environmental perspective, cattle manure reached the highest reduction of climate change and acidification impacts compared to other biomasses, while sugarcane achieved the lowest energy input consumption (around 64%). (C) 2020 Elsevier Ltd. All rights reserved.
Determination of experimental domain factors of polyphenols, phenolic acids and flavonoids of lemon (Citrus limon) peel using two-level factorial design

This study aimed to evaluate the significant extraction factors in achieving higher recovery yield of total polyphenols, phenolic acids and flavonoids content from Citrus limon peel using two-level factorial design. The effect of five independent factors including drying temperature (40-60 °C), methanol concentration (20-60%), extraction temperature (28-60 °C), extraction time (30-60 min) and storage duration (0-14 days) were evaluated. Among all the examined factors, results showed that drying temperature, storage duration and extraction temperature were the most significant and contributing factors affecting the total polyphenols, phenolic acids and flavonoids content of lemon peel at P < 0.05. On the contrary, methanol concentration and extraction time exhibited the least significant and contribution at P greater than 0.05. In conclusion, the experimental domain factors were successfully obtained from this experiment, Therefore, further study on optimization of the obtained factors will be conducted in the future study using response surface methodology.
Development of wind energy market in the European Union

Renewable energy sources (RES) can play a significant role in economic growth. This article examines the development of the wind energy market in the EU. The applicable regulations, directives, and legal acts are reviewed, and the State's role in the development of the renewable energy market is discussed. The analyses were carried out based on the available literature and Eurostat data. The authors of the paper used basic statistics to summarize the changes in wind energy and make a prognosis. The data analysis uses the Autoregressive Integrated Moving Average Method (ARIMA). The survey found that the highest average wind cumulative installed capacities were in Germany (31026 MW), Spain (18602 MW), United Kingdom (7894 MW) and France (6108 MW). Our analysis indicates that the biggest average annual installed wind capacity was in Germany (2952.6 MW), Spain (1224.5 MW) and the United Kingdom (1363.8 MW). These same countries achieved the highest average wind gross electricity production in the years 2004-17: Germany (50.9 TWh), Spain (39.3 TWh) and United Kingdom (18.9 TWh). The study finds that wind cumulative installed capacity will increase in most countries of the EU. (C) 2020 Elsevier Ltd. All rights reserved.
Spatiotemporal dynamics of ecosystem services provision in a degraded ecosystem: A systematic assessment in the Lake Urmia basin, Iran

Lake Urmia has experienced severe environmental degradation, mainly characterized by the enormous reduction of its surface area and water level. This issue has been mainly attributed to land-use and land-cover changes, in particular related to agricultural expansion and intensification. In this study, we used the DPSIR framework (D: driving forces, P: pressures, S: states, I: impacts, and R: responses) to systematically describe the ecosystem service dynamics related to anthropogenic activities and climatic parameters in the region. We reviewed the literature and used remote sensing, agricultural, climatic and hydrological data together with expert knowledge to assess the main driving forces and pressures, resulting land-use transitions and their spatiotemporal impacts on ecosystem services and biodiversity using a matrix-based assessment approach. We identified population growth, economic incentives and climate change as the most important driving forces, leading to altered agricultural activities, numerous dam constructions and droughts. Since 1987 cropland areas doubled at the expense of bare soils and natural vegetation, the lake halt lost more than half of its surface area, urban and freshwater areas increased threefold and by 50%, respectively. This favored crop and freshwater provision, while all other ecosystem services remained nearly constant or decreased, though spatial patterns were heterogeneous. For example, regulating and cultural services, and biodiversity mainly decreased at the shorelines of the lake, while provisioning services increased along the major rivers and close to cities. To address the land-use transitions with the most profound impact on ecosystem service provision, we recommend the following measures: increase the water supply to the lake, reduce cropland expansion, manage existing croplands more sustainably and protect natural vegetation. Our study provides a comprehensive overview of the regional ecosystem service dynamics and a valuable baseline for future research and environmental management in the basin. (C) 2020 Elsevier B.V. All rights reserved.
Between Justice and Money: How the Covid-19 Crisis was used to De-Differentiate Legality in Ecuador

Legality in the Global South suffers from problems of application by convenience. Some rules are applied, and some are not, depending on certain actors, such as the State, the stakeholders, or others. This undermines legitimation as constructed by legality and due process. These problems are connected to a wider complex formed by coloniality, internal colonialism, and a form of functional differentiation that limits autonomy of the different social systems. This complex of structural properties allows States and other actors to systematically use one system against the other or-within a given system-one level of rules against the other. This was the case in Ecuador: in the initial months of quarantine due to Covid-19, the government took decisions about external state bonds following international legislation-and quite contrary ones related to local work contracts. Once again, legality followed different paths in diverse cases. Ecuadorian economic authorities accept and respect conditions on external public bonds which are protected by some complex and specific clauses to secure the payment. The same authorities have different practices towards international and national legislation that were organized in the sense of legal subsidiarity. This text will explore reasons and effects of legal de-differentiation in the Global South in times of crisis. The Ecuadorian case in time of Covid-19 helps to understand how structural problems related to the lack of autonomy of the legal system are perpetuated and lead to effects of convenient political action.
Multi-objective techno-economic-environmental optimisation of electric vehicle for energy services

Electric vehicles and renewable energy sources are collectively being developed as a synergetic implementation for smart grids. In this context, smart charging of electric vehicles and vehicle-to-grid technologies are seen as a way forward to achieve economic, technical and environmental benefits. The implementation of these technologies requires the cooperation of the end-electricity user, the electric vehicle owner, the system operator and policy makers. These stakeholders pursue different and sometime conflicting objectives. In this paper, the concept of multi-objective-techno-economic-environmental optimisation is proposed for scheduling electric vehicle charging/discharging. End user energy cost, battery degradation, grid interaction and CO2 emissions in the home micro-grid context are modelled and concurrently optimised for the first time while providing frequency regulation. The results from three case studies show that the proposed method reduces the energy cost, battery degradation, CO2 emissions and grid utilisation by 88.2%, 67%, 34% and 90% respectively, when compared to uncontrolled electric vehicle charging. Furthermore, with multiple optimal solutions, in order to achieve a 41.8% improvement in grid utilisation, the system operator needs to compensate the end electricity user and the electric vehicle owner for their incurred benefit loss of 27.34% and 9.7% respectively, to stimulate participation in energy services.
Novel Technologies and Techniques for Prehospital Airway Management: An NAEMSP Position Statement and Resource Document

Novel technologies and techniques can influence airway management execution as well as procedural and clinical outcomes. While conventional wisdom underscores the need for rigorous scientific data as a foundation before implementation, high-quality supporting evidence is frequently not available for the prehospital setting. Therefore, implementation decisions are often based upon preliminary or evolving data, or pragmatic information from clinical use. When considering novel technologies and techniques. NAEMSP recommends:Prior to implementing a novel technology or technique, a thorough assessment using the best available scientific data should be conducted on the technical details of the novel approach, as well as the potential effects on operations and outcomes.The decision and degree of effort to adopt, implement, and monitor a novel technology or technique in the prehospital setting will vary by the quality of the best available scientific and clinical information:• Routine use - Technologies and techniques with ample observational but limited or no interventional clinical trial data, or with strong supporting in-hospital data. These techniques may be reasonably adopted in the prehospital setting. This includes video laryngoscopy and bougie-assisted intubation. • Limited use - Technologies and techniques with ample pragmatic clinical use information but limited supporting scientific data. These techniques may be considered in the prehospital setting. This includes suction-assisted laryngoscopy and airway decontamination and cognitive aids. • Rare use - Technologies and techniques with minimal clinical use information. Use of these techniques should be limited in the prehospital setting until evidence exists from more stable clinical environments. This includes intubation boxes.The use of novel technologies and techniques must be accompanied by systematic collection and assessment of data for the purposes of quality improvement, including linkages to patient clinical outcomes.EMS leaders should clearly identify the pathways needed to generate high-quality supporting scientific evidence for novel technologies and techniques.
Can industrial agglomeration promote pollution agglomeration? Evidence from China

After industrial agglomeration has developed to a certain extent, its negative externality will appear gradually, and the problem of environmental pollution will become serious. In this study, a comprehensive index of pollution emission is calculated by the improved entropy method, and the pollution agglomeration level is obtained through the geographical concentration. The degree of industrial agglomeration is estimated by the location quotient index. The impact of industrial agglomeration on pollution agglomeration is investigated by using the model of Geographically and Temporally Weighted Regression (GTWR). The main results are as follows. (1) There is spatial autocorrelation between pollution agglomeration and industrial agglomeration in China. (2) At the national level, industrial agglomeration increases the pollution agglomeration. (3) At the provincial level, industrial agglomeration has a positive effect on the pollution agglomeration, but the degrees of influence in different regions are different. The positive effect in the northern region (such as Inner Mongolia, Heilongjiang, and Jilin) and the eastern region (such as Beijing, Tianjin, and Liaoning) is the strongest, whereas the effect in the western region (such as Sichuan, Guizhou, and Guangxi) is on the low side. (4) The relationship between industrial agglomeration and pollution agglomeration is relatively stable from the time perspective, and it may be hard to weaken the positive effect over a short time. To improve the environmental quality, this study puts forward some suggestions, such as optimising high-tech industrial agglomeration and strengthening the regional linkage. (C) 2019 Elsevier Ltd. All rights reserved.
Energy, exergy, environmental, and economic analysis of natural and forced cooling of solar still with porous media

The performance of single slope solar still with an enhanced condenser at different saline water mediums in the basin is studied and assessed based on productivity, energy, exergy, economic, and enviroeconomic methodologies. Six solar still configurations are considered: conventional solar still (CSS); modified solar still (MSS) which is a still with heat sink condenser; MSS having an umbrella (MSS + U); MSS with forced-air cooling (MSS + FA); MSS with forced-water cooling (MSS + FW); and finally, MSS with forced-water cooling and contains sand in the basin (MSS + FW + SD). Experiments are conducted under hot and cold climate conditions of Sohag city, Egypt. The results indicate that the MSS + FW + SD has a maximum daily yield of 5.37 kg/m(2)in summer and 2.74 kg/m(2)in winter with an increase of 36% in summer and 26% in winter compared with CSS. It was found that the maximum increase of the energy and exergy efficiency compared with CSS is achieved in the case of MSS + FW + SD of 39% and 33%, respectively. Furthermore, the maximum and minimum cost of freshwater is achieved in cases of MSS + U and MSS + FW + SD, respectively. Finally, among all studied systems, MSS + FW + SD achieves the best performance based on the exergoeconomic approach.
The Effect on Venous Congestion of Diverting Arterial Flow in the Arterialized Venous Flap

An arterialized venous flap is a cutaneous flap based solely on subcutaneous veins. The flap is perfused by nonphysiologic flow of blood from the vein into the peripheral tissue. This nonphysiologic perfusion limits the indications for an arterialized venous flap, and its postoperative complications make it an unpopular choice for reconstruction. When venous flaps are designed following the direction of venous valves (antegrade) in a flow-through fashion, the blood may bypass the peripheral tissue without perfusing the flap. A higher pressure within the efferent end of the vein impedes venous return from the peripheral tissue into this draining vein. Thus, venous congestion of the arterialized venous flap becomes inevitable. We describe our approach to designing an arterialized venous flap in which direct arteriovenous shunting is largely eliminated, thereby transmitting a higher pressure in the periphery of the flap while maintaining a physiologic venous pressure in the efferent vein. This restriction of shunting can be accomplished in a number of ways, depending on the venous pattern within the flap.
Vaspin attenuates steatosis-induced fibrosis via GRP78 receptor by targeting AMPK signaling pathway

Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that is rapidly becoming a public health problem. An imbalance in lipid distribution to the hepatocytes and metabolism causes hepatocyte steatosis. Vaspin is a newly discovered adipokine that has been linked to a variety of metabolic disorders. The effects of vaspin on steatosis and fibrosis pathogenesis and related mechanisms are unclear. Thus, this study investigated the molecular mechanism of vaspin on hepatocyte steatosis and fibrosis. HepG2 cells were treated with 1.2 mM free fatty acid and the intracellular lipid values were measured by flow cytometry and Nile red assay. RT-qPCR was used to assess the effect of vaspin and blocking of the GRP78 receptor on the expression of lipogenesis, oxidation, uptake, and secretion of fatty acid (FA), as well as AMPK activity. In co-cultured HepG2 and LX-2 cell lines, the expression of main proteins of hepatocyte fibrosis was analyzed using Western blot analysis. In the HepG2 cell line, we discovered that vaspin increased oxidation, FA secretion and gene expression, and AMPK activity and decreased lipogenesis and FA uptake and gene expression. Western blot analysis in co-cultured HepG2 and LX-2 cell lines showed that α-SMA and TGF-β1 protein expression decreased. The data demonstrated that vaspin acts as a novel regulator of hepatocyte steatosis through the GRP78 receptor, effectively reducing hepatocyte fibrosis through AMPK activation and decreasing NF-κB gene expression.
Total Synthesis of Oxepin and Dihydrooxepin Containing Natural Products

The construction of oxepin and dihydrooxepin containing natural products represents a challenging task in total synthesis. In the last decades, a variety of synthetic methods have been reported for the installation of these structural motifs. Herein, we provide an overview of synthetic methods and strategies to construct these motifs in the context of natural product synthesis and highlight the key steps of each example.
Behavioural and physiological plasticity in social hierarchies

Individuals occupying dominant and subordinate positions in social hierarchies exhibit divergent behaviours, physiology and neural functioning. Dominant animals express higher levels of dominance behaviours such as aggression, territorial defence and mate-guarding. Dominants also signal their status via auditory, visual or chemical cues. Moreover, dominant animals typically increase reproductive behaviours and show enhanced spatial and social cognition as well as elevated arousal. These biobehavioural changes increase energetic demands that are met via shifting both energy intake and metabolism and are supported by coordinated changes in physiological systems including the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes as well as altered gene expression and sensitivity of neural circuits that regulate these behaviours. Conversely, subordinate animals inhibit dominance and often reproductive behaviours and exhibit physiological changes adapted to socially stressful contexts. Phenotypic changes in both dominant and subordinate individuals may be beneficial in the short-term but lead to long-term challenges to health. Further, rapid changes in social ranks occur as dominant animals socially ascend or descend and are associated with dynamic modulations in the brain and periphery. In this paper, we provide a broad overview of how behavioural and phenotypic changes associated with social dominance and subordination are expressed in neural and physiological plasticity. This article is part of the theme issue 'The centennial of the pecking order: current state and future prospects for the study of dominance hierarchies'.
Safinamide protects against amyloid β (Aβ)-induced oxidative stress and cellular senescence in M17 neuronal cells

Alzheimer's disease (AD) is a neurodegenerative disorder that is pathologically related to oxidative stress and cellular senescence. Safinamide is one of the clinically prescribed monoamine oxidase B (MAOB) inhibitors. It has been reported to possess therapeutic potential in neurological disorders. However, the therapeutic potential of safinamide in AD is still under investigation. In this study, we explored the effect of safinamide in amyloid (Aβ)1-42 oligomers-stimulated M17 neuronal cells. We established the in vitro model with M17 cells by treating them with 1 μM Aβ1-42 oligomers with or without safinamide (100 or 200 nM). The results show that safinamide ameliorated Aβ1-42 oligomers-induced oxidative stress in M17 cells as revealed by the decreased reactive oxygen species (ROS) production and reduced glutathione (GSH) content. Safinamide treatment significantly ameliorated senescence-associated-β-galactosidase (SA-β-gal)-positive cells and telomerase activity. Further, we show that safinamide treatment resulted in decreased mRNA and protein expressions of p21 and plasminogen activator inhibitor-1 (PAI-1). Moreover, silencing of Sirtuin1 (SIRT1) abolished the effects of safinamide on the mRNA levels of p21 and PAI-1, as well as SA-β-gal-positive cells in Aβ1-42 oligomers-induced M17 cells. In conclusion, we reveal that safinamide exerted a protective function on M17 cells from Aβ1-42 oligomers induction-caused oxidative stress and cellular senescence through SIRT1 signaling. These present results provide meaningful evidence that safinamide may be medically developed for the prevention and therapy of AD.
Anti-SARS-CoV-2 spike protein and neutralizing antibodies at 1 and 3 months after three doses of SARS-CoV-2 vaccine in a large cohort of solid organ transplant patients

The immunogenicity of the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) vaccine was improved by the administration of a third dose. The aim of our retrospective study was to assess the evolution of binding and neutralizing antibody concentration until 3 months after the third dose in a large cohort of solid organ transplant (SOT) patients (n = 872). At 1 month after the third dose, anti-SARS-CoV-2 antibodies were detected by means of enzyme-linked immunosorbent assay tests in 578 patients (66.3%). In a subgroup of patients, 70% (180 out of 257) had anti-SARS-CoV-2 antibody concentrations ranging from 1.2 to 18 411 binding antibody units (BAU)/ml and 48.5% (115 out of 239) had a neutralizing antibodies titer that can confer clinical protection against SARS-CoV-2. Three-hundred ninety-three patients out of the 416 (94.5%) who were seropositive at month 1 and were tested at 3 months after vaccination remained seropositive. Between months 1 and 3 after vaccination, binding and neutralizing antibodies concentrations decreased significantly. The proportion of protected patients against the SARS-CoV-2 also slightly decreased. In conclusion, this study shows that although two-third of SOT develop anti-SARS-CoV-2 antibodies after three doses, one-third of them remain weak or non-protected. It is important to measure anti-SARS-CoV-2 antibodies to define the strategy that can optimize SOT protection against SARS-CoV-2.