ahmedabdelwahed/Medical_papers_title_and_abstract_NLP_dataset huggingface dataset:
Spatiotemporal Activity Modeling via Hierarchical Cross-Modal Embedding

With the ever-increasing urbanization process, modeling people's spatiotemporal activities from their online traces has become a crucial task. State-of-the-art methods for this task rely on cross-modal embedding, which maps items from different modalities (e.g., location, time, text) into the same latent space. Despite their inspiring results, existing cross-modal embedding methods merely capture co-occurrences between items without modeling their high-order interactions. In this paper, we first construct two graphs from raw data records to represent the user interaction graph layer and activity graph layer and propose a hierarchical cross-modal embedding method that takes the high-order relationships into consideration. The key notion behind our method is a novel hierarchical embedding framework with meta-graphs connecting different layers. We introduce both inter-record and intra-record meta-graph structures, which enable learning distributed representations that preserve high-order proximities across graphs from different layers. Our empirical experiments on three real-world datasets demonstrate that our method not only outperforms state-of-the-art methods for spatiotemporal activity prediction, but also captures cross-modal proximity at a finer granularity.
Mining consistent correspondences using co-occurrence statistics

In this paper, we propose a mismatch removal method, which mines consistent image feature correspon-dences using co-occurrence statistics. The proposed method relies on a co-occurrence matrix that counts the number of pixel value pairs co-occurring within the images. Specifically, we propose to integrate the co-occurrence statistics with local spatial information, to preserve the consensus of neighborhood ele-ments. Then, a new measure based on co-occurrence statistics is defined for correspondence similarity, to preserve the consensus of neighborhood topology. After that, with the consensus of neighborhood el-ements and neighborhood topology, the mismatch removal problem is formulated into a mathematical model, which has a closed-form solution. Extensive experiments show that the proposed method is able to achieve superior or competitive performance on matching accuracy over several state-of-the-art com-peting methods. In addition, we further exploit the consensus of neighborhood elements and neighbor-hood topology to propose a novel guided sampling method, which can significantly improve the quality of sampling minimal subsets over state-of-the-arts for two-view geometric model fitting. (c) 2021 Elsevier Ltd. All rights reserved.
Can erythema multiforme be an immune sequela of IgM nephropathy? A case report

A 13-year-old Chinese girl attended to our Pediatric Dermatology Unit for the appearance of itchy targetoid lesions on the trunk, face and upper limbs. A skin biopsy showed histological findings typical of erythema multiforme minor. A month earlier she was admitted for the onset of a nephrotic syndrome and the renal biopsy showed an IgM nephropathy with a diffuse mesangial cell proliferation. There was no medical history of recent infections, fever, muscle or joint pain, drugs intake related to erythema multiforme and viral serology were negative.The role of antibodies in erythema multiforme could be more relevant than suspected and the severity of erythema multiforme was reported to be proportional to the antibody-mediated complement-dependent cytotoxicity, supporting the potential pathogenetic role for humoral immunity in this subtype of erythema multiforme.We reported the first association of erythema multiforme and IgM nephropathy in a pediatric patient providing an additional hint that an antibody-mediated process, rather than T-cell cytotoxicity, might represent the main pathogenetic mechanism in certain subtypes of erythema multiforme.
TAKer: Fine-Grained Time-Aware Microblog Search with Kernel Density Estimation

Temporal information has been widely used to promote the information retrieval (IR) performance, especially for microblog search which usually prefers the latest news and events. Previous studies mainly focused on incorporating the document-level temporal information into retrieval, while the temporal relevance of each query word was not well investigated. In this paper, we propose a word temporal predictor to characterize the word-level temporal relevance by fine-grained time-aware kernel density estimation over the feedback documents. In addition, we present a fine-grained time-aware framework to integrate the proposed word temporal predictor with the traditional document temporal predictor for retrieval. Finally, we incorporate the framework into two state-of-the-art retrieval models, namely language model (LM) and BM25. The experimental results on the TREC 2011-2014 Microblog collections, show that our proposed word temporal predictor is effective to boost the retrieval performance within both LM and BM25 frameworks. In particular, we achieve significant improvements over the strong baselines with optimized settings in most cases. Furthermore, our fine-grained time-aware models with word temporal predictor are comparable to if not better than the state-of-the-art temporal retrieval models.
Ambient air pollution on fecundity and live birth in women undergoing assisted reproductive technology in the Yangtze River Delta of China

Background: Ambient air pollution has adverse effects on the reproductive system. However, inconsistent con-clusions were reached from different studies with regard to air pollutants and pregnancy outcomes, especially the livebirth rate in assisted reproductive technology (ART) in different windows of exposure.& nbsp;Methods: A retrospective cohort study was conducted on 12,665 women who underwent first fresh or frozen embryo transfer cycle in the Yangtze River Delta of China. Daily average levels of six air pollutants in four different periods were obtained: Period 1 and 2: 90 days or one year prior to oocyte retrieval; Period 3 and 4: the day of oocyte retrieval or one year prior to oocyte retrieval to the day of serum hCG test or to the end of the pregnancy. A multiple logistic regression model was used to investigate the association between air pollutant exposure and pregnancy outcomes. Stratified analyses were conducted to explore potential modifier effects.& nbsp;Results: The one year exposure window (Period 2) before oocyte retrieval had a more evident negative associ-ation with pregnancy outcomes. Each IQR increase in ambient PM10 (OR: 0.89, 95% CI: 0.84-0.93), PM2.5 (OR: 0.82, 95% CI: 0.77-0.87), SO2 (OR: 0.87, 95% CI: 0.83-0.91) and CO (OR: 0.91, 95% CI: 0.87-0.96) was associated with a respective 11%, 18%, 13% and 9% decrease in the likelihood of live birth. In entire exposure window of Period 4, all air pollutants except for O-3 were associated with a decreased likelihood of live birth. Stratified analyses showed that women undergoing frozen embryo transfer cycles, especially those with two embryos transferred, were more vulnerable to air pollutant exposure.& nbsp;Conclusion: This study indicates a negative association between air pollutant exposure before oocyte retrieval and livebirth rate in ART. The adverse impact was more evident in one year exposure compared to three-month refresh cycle of the gametes. Additional protection from air pollution should be undertaken at least one year before ART, particularly for those with frozen embryo transfer cycles.
Analysis of the importance of art elements in the construction of ecological environment in the new era

With the development of economy, people have higher and higher requirements for living art. A good ecological environment is the guarantee of creating an aesthetic environment. Taking the ecological environment construction of ecological town as an example, this paper analyses the importance of integrating artistic elements into the ecological environment construction in the new era from the perspective of environmental aesthetics. Based on the concept of "three life integration" and "garden city theory", this paper creatively puts forward the construction methods and models of ecological environment in contemporary small towns. Based on the height of environmental aesthetics, this paper analyses the planning and construction process of characteristic town and the evaluation and acceptance criteria of ecological environment design, summarises its successful experience and main problems, and makes a retrospective summary and reflection. This paper analyses the importance of the integration of art elements into the ecological town in the new era. The results show that in the new era of ecological environment construction, the integration of art elements can not only improve the quality of ecological environment construction, but also improve the common people's cognition of ecological beauty.
TCR signaling to NF-κB and mTORC1: Expanding roles of the CARMA1 complex

Naïve T-cell activation requires signals from both the T-cell receptor (TCR) and the costimulatory molecule CD28. A central mediator of the TCR and CD28 signals is the scaffold protein CARMA1, which functions by forming a complex with partner proteins, Bcl10 and MALT1. A well-known function of the CARMA1 signaling complex is to mediate activation of IκB kinase (IKK) and its target transcription factor NF-κB, thereby promoting T-cell activation and survival. Recent evidence suggests that CARMA1 also mediates TCR/CD28-stimulated activation of the IKK-related kinase TBK1, which plays a role in regulating the homeostasis and migration of T cells. Moreover, the CARMA1 complex connects the TCR/CD28 signals to the activation of mTORC1, a metabolic kinase regulating various aspects of T-cell functions. This review will discuss the mechanism underlying the activation of the CARMA1-dependent signaling pathways and their roles in regulating T-cell functions.
EEPROM endurance degradation at different temperatures: State of the art TCAD simulation

Electrically Erasable Programmable Read Only Memory (EEPROM) is a widely used memory device, nowadays implemented in submicron technology nodes. In this paper we show how the well-known trapping power law found in the literature can be retrieved by combining well calibrated state of the art Technology Computer AidedDesign (TCAD) simulations with a compact model for tunnel oxide degradation during EEPROM cycling. We pinpoint how this approach can be used to predictively assess the programming window closure and consequently, considerably reduce the time-consuming cycling test procedure. Finally, we show how this methodology can cover a wide range of temperatures, making it very attractive for high demanding applications such as automotive.
Mortality prediction of the frailty syndrome in patients with severe mitral regurgitation

In this prospective observational study, we investigated the impact of geriatric syndromes and frailty on mortality and evaluated the prognostic value of different frailty, nutritional, and geriatric assessment tools in high-risk patients with severe mitral valve regurgitation (MR) who were evaluated for mitral valve therapies including surgical, interventional, and conservative treatment options. We prospectively assessed multiple parameters including the CONUT Score, the Katz Index of independence in activities of daily living (ADL), the Fried Frailty Phenotype (FFP), and the Essential Frailty Toolset (EFT) Score in 127 patients with severe symptomatic MR requiring surgical/interventional treatment versus conservative monitoring. We compared their predictive value on mortality including multivariate regression analysis to identify the most suitable tool to predict outcomes in these patient groups. The frailty syndrome as assessed with the CONUT Score, Katz Index, EFT Score, and FFP was associated with higher rates of comorbidities, significantly higher risk scores such as logistic EuroSCORE, EuroSCORE II, and STS-PROM, and significantly higher mortality rates. The EFT Score and FFP were independent predictors of one-year all-cause mortality in our study cohort (EFT Score: HR 1.9, 95% CI 1.2 to 3.2; p = 0.01; FFP: HR 1.8, 95% CI 1.1 to 3.1; p = 0.015). Geriatric syndromes and frailty are associated with increased mortality in high-risk patients with symptomatic severe MR. The EFT Score and the FFP were independent predictors of one-year all-cause mortality.
Evaluation of Hierarchical Watersheds

This paper aims to understand the practical features of hierarchies of morphological segmentations, namely the quasi-flat zones hierarchy and watershed hierarchies, and to evaluate their potential in the context of natural image analysis. We propose a novel evaluation framework for the hierarchies of partitions designed to capture various aspects of those representations: precision of their regions and contours, possibility to extract high quality horizontal cuts and optimal non-horizontal cuts for image segmentation, and the ease of finding a set of regions representing a semantic object. This framework is used to assess and to optimize hierarchies with respect to the possible pre- and post-processing steps. We show that, used in conjunction with a state-of-the-art contour detector, watershed hierarchies are competitive with the complex state-of-the-art methods for hierarchy construction. In particular, the proposed framework allows us to identify a watershed hierarchy based on a novel extinction value, the number of parent nodes that outperforms the other hierarchies of morphological segmentations. This coupled with the fact that watershed hierarchies satisfy clear global optimality properties and can be efficiently computed on large data, make them valuable candidates for various computer vision tasks.
Monocular Pedestrian Detection: Survey and Experiments

Pedestrian detection is a rapidly evolving area in computer vision with key applications in intelligent vehicles, surveillance, and advanced robotics. The objective of this paper is to provide an overview of the current state of the art from both methodological and experimental perspectives. The first part of the paper consists of a survey. We cover the main components of a pedestrian detection system and the underlying models. The second (and larger) part of the paper contains a corresponding experimental study. We consider a diverse set of state-of-the-art systems: wavelet-based AdaBoost cascade [74], HOG/linSVM [11], NN/LRF [75], and combined shape-texture detection [23]. Experiments are performed on an extensive data set captured onboard a vehicle driving through urban environment. The data set includes many thousands of training samples as well as a 27-minute test sequence involving more than 20,000 images with annotated pedestrian locations. We consider a generic evaluation setting and one specific to pedestrian detection onboard a vehicle. Results indicate a clear advantage of HOG/linSVM at higher image resolutions and lower processing speeds, and a superiority of the wavelet-based AdaBoost cascade approach at lower image resolutions and (near) real-time processing speeds. The data set (8.5 GB) is made public for benchmarking purposes.
A quantitative analysis of phenotypic variations of Metrosideros polymorpha within and across populations along environmental gradients on Mauna Loa, Hawaii

Metrosideros polymorpha, a dominant tree species in the Hawaiian Islands, shows an extreme phenotypic polymorphism both across gradients of climatic/edaphic conditions and within populations, making it a potentially useful model species for evolutionary study. In order to understand how the phenotypic diversity is maintained within populations as well as across populations, we examined the diversities of several leaf and stem functional traits across five elevations and two soil substrates on the volcanic mountain of Mauna Loa, on the island of Hawaii. Leaf dry mass per area (LMA), a key leaf functional trait, was particularly focused on and analyzed in relation to its underlying components-namely, tissue LMA and trichome LMA (LMA = tissue LMA + trichome LMA). Across populations, tissue LMA increased linearly with elevation while trichome LMA showed unimodal patterns with elevation, which were better correlated with temperature and rainfall, respectively. Substantial phenotypic variations were also found within populations. Interestingly, the variations of tissue LMA were often negatively correlated to trichome LMA within populations, which contrasts with the cross-populations pattern, where a strong positive correlation between tissue LMA and trichome LMA was found. This suggests that phenotypic variations within populations were substantially influenced by local ecological processes. Soil depth (an indicator of local water availability) and tree size (an indicator of colonized timing) modestly explained the within-population variations, implying other local environmental factors and/or random processes are also important in local phenotypic diversity. This study provides an insight about how phenotypic diversity of plant species is maintained from local to landscape levels.
A Conceptual Framework for Interacting Landscape Architects and Urban Designers: Professionals' Perspectives

Urban design and landscape Architecture are considered as modem Art (knowledge) which are developed through integration of various Art and science fields of studies. Formal emergence of urban design in 60s and landscape design is occurred at the beginning of 20th century. The success of these two fields is because of their attention to environmental qualities upgrade in public and opal spaces all over cities. Indeed, these two fields have got similar approaches to designing open spaces; this article is looking forward to deliver proposals regarding suitable integration among experts of these two fields.This research is based on a qualitative and quantitative approach; using 'grounded theory method' and applying 'content analysis' in questions extractions analyze the practical mechanisms among everts in these two fields in Iran. The emphasis of this research in procedural aspect is based on the four-level order of relations among design component including: design-planning, management-guidance, control-policy and conservation-catalyzing, as the most important common role of urban design and landscape architecture, is to achieve an effective interaction pattern. In addition, to substantial aspect designing urban landscape and urban spaces is considered as a common subject among landscape architects and urban designers. At the end, based on incorporation of substantial and procedural components, a system of correlation between these two fields is proposed.
Pattern of associated brain injury in maxillofacial trauma: a retrospective study from a high-volume centre

The incidence of head injury in maxillofacial trauma patients varies widely in the literature. A good understanding of the patterns of association between these injuries would aid in efficient multidisciplinary treatment. The aim of this study therefore was to understand the associations between head injury and facial trauma by retrospectively analysing the records of patients seen at a tertiary care trauma centre. Demographic data were also described. Records of 4350 facial trauma patients over a five-year period were reviewed. A total of 3564 (81.9%) patients were victims of motor vehicle accidents (MVA). Male patients predominated, comprising 3711 (85.3%), and 36.6% were in the third decade of life. Facial fractures were seen in 2120 (48.7%), the most common being zygomatic fractures (60%). At the time of trauma, 2383 (57.3%) patients were under the influence of alcohol, and 2821 (87.8%) victims of two-wheeler MVAs were not using their helmet. Of all patients, 29.75% sustained a traumatic brain injury (TBI). Midface fractures were strongly associated with TBI. Maxillofacial injury may be considered a risk factor for TBI, and as such should immediately be suspected and investigated in all patients. Prompt recognition and management can improve outcomes in these patients.
Rock varnish on petroglyphs from the Hima region, southwestern Saudi Arabia: Chemical composition, growth rates, and tentative ages

We investigated rock varnish formed on sandstone and petroglyphs in the Hima area, southwestern Saudi Arabia. To characterize the rock varnish, we made in-situ measurements by portable x-ray fluorescence (pXRF) and analyzed samples by femtosecond laser-ablation inductively coupled-plasma mass spectrometry (fs LA-ICP-MS). Detailed chemical analysis of the rock varnish samples and adjacent soil or aeolian dust yielded information about the varnish's geochemical context and formation mechanism. Untypically low positive Ce anomalies in the rock varnish samples correlated with negative Ce anomalies in the dust, supporting the hypothesis that the dust is the source of the varnish material. To study the varnish development, we made use of the fact that engraving the petroglyphs exposes a fresh bare sandstone surface without varnish, on which varnish regrows subsequently. We determined by pXRF the areal density of manganese (Mn) and iron (Fe) that had been deposited as rock varnish since the creation of the rock art. The rates of Mn deposition in the newly formed varnish were then estimated by correlating the areal density of Mn in Ancient Arabian and Old Arabic inscriptions with their known age ranges. The observed deposition rates showed substantial variability resulting from differences in exposure conditions of the rock surface, but were in a range comparable with that of our previous measurements in northwestern Arabia. This variability could be reduced significantly by referencing the measurements to the intact varnish adjacent to the individual petroglyphs. This normalization provided a much clearer relationship between varnish deposition and age, and enabled tentative ages to be assigned to rock art motifs without previously known ages. These tentative ages spanned most of the Holocene period and were consistent with the culturally or ecologically derived ages of the animal and human figures depicted in the rock art and the styles of scripts used in different periods.
Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators

The α7 nicotinic acetylcholine receptor is a pentameric ligand-gated ion channel that modulates neuronal excitability, largely by allowing Ca2+ permeation. Agonist binding promotes transition from a resting state to an activated state, and then rapidly to a desensitized state. Recently, cryogenic electron microscopy (cryo-EM) structures of the human α7 receptor in nanodiscs were reported in multiple conformations. These were selectively stabilized by inhibitory, activating, or potentiating compounds. However, the functional annotation of these structures and their differential interactions with unresolved lipids and ligands remain incomplete. Here, we characterized their ion permeation, membrane interactions, and ligand binding using computational electrophysiology, free-energy calculations, and coarse-grained molecular dynamics. In contrast to nonconductive structures in apparent resting and desensitized states, the structure determined in the presence of the potentiator PNU-120596 was consistent with an activated state permeable to Ca2+. Transition to this state was associated with compression and rearrangement of the membrane, particularly in the vicinity of the peripheral MX helix. An intersubunit transmembrane site was implicated in selective binding of either PNU-120596 in the activated state or cholesterol in the desensitized state. This substantiates functional assignment of all three lipid-embedded α7-receptor structures with ion-permeation simulations. It also proposes testable models of their state-dependent interactions with lipophilic ligands, including a mechanism for allosteric modulation at the transmembrane subunit interface.