ahmedabdelwahed/Medical_papers_title_and_abstract_NLP_dataset huggingface dataset:
Anatomical position of the palmar/plantar nerves at the metacarpal/metatarsal distal level in horses: An in vivo study by means of ultrasonography

The neurovascular bundle of the equine distal cannon can dynamically vary with limb position, and this can affect the performance of low 4- or 6-point block. This study aims to identify and describe the anatomical position and variations of the lateral and medial palmar/plantar nerve at the metacarpal/metatarsal distal level in horses by ultrasonography. Eight mares underwent ultrasound examination on the lateral and medial palmar/plantar sides of the metacarpus/metatarsus. Images were obtained for measurements of the cross-sectional area of the nerve, distances between the nerve and the skin surface, branch of the suspensory ligament (SL), deep digital flexor tendon (DDFT) and superficial digital flexor tendon (SDFT) with limbs supported and elevated. The distance to the skin for forelimbs was higher on the lateral side when the limb was elevated (p < 0.001). The comparisons between supported and elevated limbs on the same side showed longer distances to the skin with the limb supported on the medial side (p < 0.001). Hindlimbs showed longer distances to the skin with the limb supported on the medial face (p = 0.027). The anatomical position of palmar/plantar nerves was similar between the lateral and medial sides of the limb, generally being in contact with the dorsal edge of DDFT. The strategy of elevating the limb during the injection of the low 4- or 6-point block can lead to a higher risk of puncture of the digital sheath.
Meeting the needs of patients with ultrarare diseases

Patients with ultrarare diseases present unique challenges to the health care systems of developed economies that demand novel approaches, beginning with achieving a diagnosis and concluding with long-term treatment. The challenges derive from numbers. On the one hand, the rarity of the disease phenotypes means that the vast majority of ultrarare patients are never diagnosed, and for the fortunate few who are diagnosed, the journey to a genetic diagnosis is long and perilous. On the other hand, as more human genomes are sequenced, the number of these patients identified is growing logarithmically. Once patients are diagnosed, personalized medicines must be rapidly developed and delivered. Here I define the problems and propose a nonprofit model to meet the needs of some of these patients.
Trichodysplasia spinulosa polyomavirus small T antigen synergistically modulates S6 protein translation and DNA damage response pathways to shape host cell environment

TSPyV is a viral agent linked to Trichodysplasia spinulosa, a disfiguring human skin disease which presents with hyperkeratotic spicule eruption in immunocompromised hosts. This proliferative disease state requires extensive modulation of the host cell environment. While the small T (sT) antigen of TSPyV has been postulated to cause widespread cellular perturbation, its specific substrates and their mechanistic connection are unclear. To identify the cellular substrates and pathways perturbed by TSPyV sT and propose a nuanced model that reconciles the multiple arms of TSPyV pathogenesis, changes in expression of several proteins and phospho-proteins in TSPyV sT expressing and TSPyV sT deletion mutant-expressing cell lysates were interrogated using Western blot assays. TSPyV sT expression exploits the DNA damage response pathway, by inducing hyperphosphorylation of ATM and 53BP1 and upregulation of BMI-1. Concurrently, sT dysregulates the S6 protein translation pathway via hyperphosphorylation of CDC2, p70 S6 kinase, S6, and PP1α. The S6S244/247 and p-PP1αT320 phospho-forms are points of overlap between the DDR and S6 networks. We propose a mechanistic rationale for previous reports positioning sT antigen as the key driver of TSPyV pathogenesis. We illuminate novel targets in the S6 and DDR pathways and recognize a potential synergy between these pathways. TSPyV may sensitize the cell to both unrestricted translation and genomic instability. This multi-pronged infection model may inform future therapeutic modalities against TSPyV and possibly other viruses with overlapping host substrates.
Techno-enviro-economic assessment of household and community energy storage in the UK

Residential electricity demand is expected to rise in the next few decades due to the electrification of heating and transport. Both European and UK national policies suggest that efforts should be made to reduce carbon emissions and increase the share of renewable energy, an important element of which is encouraging generation, typically PV, in partnership with energy storage systems in the residential sector. The scale of the energy storage system is important, i.e. in individual properties or as a community resource. Many advantages of community energy storage (CES) over household energy storage (HES) have been identified, but the design and operation of CES has received significantly less attention. Most existing research has analysed CES at community level only, but the performance and impact on individual households has yet to be fully explored. In this study an agent-based model is proposed to investigate and analyse CES based on a range of criteria. Results indicate that both HES and CES can significantly reduce the grid peak power import and export, improve the community self-consumption rate (SCR) and self-sufficiency rate (SSR), and contribute to much higher energy saving. Furthermore, optimising the CES capacity leads to more effective use of PV power and better demand localisation during high PV-generation periods. It is found that an important challenge for CES systems is to realise the value of the shared electricity equitably amongst the participants and potentially to seek other revenue streams.
Therapeutic prospects of endophytic Bacillus species from Berberis lycium against oxidative stress and microbial pathogens

Endophytes are microorganisms residing within plant tissues. Bacterial endophytes are important sources for production of pharmaceutically important metabolites. Berberis lycium is an important medicinal plant and there exist no report regarding isolation and determination of bioactive potential of its bacterial endophytes. Therefore the present study was aimed to isolate and identify bacterial endophytes from Berberis lycium. The study resulted in isolation of 20 strains of bacterial endophytes. Based on their antibacterial activity three strains were identified as Bacillus cereus (LBL6), Bacillus thuringiensis (SBL3) and Bacillus anthracis (SBL4) on basis of 16SrRNA gene using universal primers. Crude ethyl acetate extracts of LBL6, SBL3 and SBL4 were further evaluated for antioxidant and antifungal activities. Moderate antioxidant activity (56 %) at a concentration of 1000 µg/mL was observed for LBL6 followed by 45 and 43 % activity by SBL4 and SBL3 respectively. Significant antifungal activity was observed against Aspergillus niger (60 %) and Aspergillus flavus (56 %) at concentration of 4 mg/mL of SBL3 and SBL4 respectively. GCMS analysis of extract (LBL6) exhibited presence of 12 bioactive secondary metabolites corresponding to antimicrobial, antifungal, antioxidant, antitumor and anticancer activities. In conclusion, present study highlighted the importance of Berberis lycium to host diverse bacterial endophytes of pharmaceutical importance.
Localized peripheral neuropathic pain: topical treatment with lidocaine 700 mg medicated plaster in routine clinical practice

Aim: To provide real-world evidence for the effectiveness and tolerability of lidocaine 700 mg medicated plaster (LMP) in localized peripheral neuropathic pain (l-PNP) treatment compared with first-line oral medications (OM). Patients & methods: This was a noninterventional, retrospective 6-month cohort study in patients refractory to at least one recommended OM, using anonymized medical care data from the German Pain eRegistry. Treatment groups were matched by propensity scoring, considering seven predefined confounding factors. The primary effectiveness end point was the absolute change in average pain intensity index from baseline at weeks 4, 12 and 24 of treatment and over the treatment period. Results: A total of 3081 datasets were retained per treatment group. LMP provided superior pain reductions and significantly greater improvements in pain-related impairments of daily living and quality of life with significantly better tolerability (p < 0.001 for all parameters) than OM. Conclusion: These real-world data confirm the effectiveness and good tolerability of LMP for l-PNP treatment under routine medical care.
Behavioural changes and flight response of a mosquito (Culicidae) and an earthworm (Lumbricidae), respectively, after exposure to imidacloprid

A major point of concern in ecotoxicology is the effects of pesticides on nontarget organisms. This can impact the ecological role played by certain beneficial species in nature. Regarding neonicotinoid insecticides such as imidacloprid (IMI), several measures, including limited trade, restrictive use, and ban have been implemented in Europe and the USA but not globally. The goal of our study was to evaluate the potential risk of this still widely used agrochemical on the behaviour of mosquito larvae (Culicidae) and the escape behaviour of earthworms (Lumbricidae). Changes in breathing, swimming and resting were recorded in mosquitoes postexposure to 0, 1 and 2 mg IMI/L for 10 min. Earthworms were topically exposed in water for 2 minutes to 0, 5, 10 and 20 mg IMI/L. The escape behaviour (initial escape distance and speed) of the earthworms were recorded. In culicids, resting particularly was significantly increased by the exposure to imidacloprid (p < 0.05). In earthworms, the initial escape distance was statistically longer (p < 0.05) when fleeing from the 5 mg IMI/L solution than the solutions with the two highest concentrations. The worms exposed to the 5 mg IMI/L reacted faster than those exposed to the higher concentrations, which explained the long distance covered in the same amount of time. These results point to the relatively quick onset of the neurotoxic effects of imidacloprid, crippling earthworms and altering the buoyancy of mosquito larvae. The ecological consequences of these findings on the completion of life cycles and the survival of these species in nature are yet to be established.
A possible indicator for removal of a large foreign body from the esophagus via a cervical approach: a case report with literature review

Foreign body intake in adults is more common among people with mental illness. Edentulous adults are at increased risk for foreign body ingestion, including of dentures. We experienced a patient who aspirated a large denture that we removed via a cervical surgical approach. A 72-year-old woman presented complaining of chest discomfort. Her medical history revealed that she suffered from schizophrenia and deafness. She had previously visited another hospital for possible loss of her denture. Chest discomfort and pain began the next day. Computed tomography showed the accidentally swallowed denture in her esophagus. Upper gastroendoscopy was attempted to remove the denture via endoscopic forceps, but it was too large to be removed and was strongly stuck. As it was difficult to perform open right thoracotomy due to left pneumonia and there was no perforation or mediastinitis, we decided to remove the denture via a left neck skin incision under general anesthesia. The denture was located in a gap between the aortic arch and vertebral body. The denture was grasped with pean forceps and extracted. The patient was discharged from hospital 18 days postoperatively. This case suggests how high a foreign body in the esophagus can be reached from a cervical incision.
Multi-criteria decision analysis (MCDA) method for assessing the sustainability of end-of-life alternatives for waste plastics: A case study of Norway

Plastic, and its pollution of marine ecosystems, has emerged as a global concern. Among the several other sources, plastics from abandoned, lost, or discarded fishing gears (ALDFG), and ropes are considered the most dangerous for marine wildlife. In EU states, the management ALDFG is prioritized through a dedicated action plan owing to the hazardous nature of ALDFG and the increase in commercial fishing activity in EU waters.The action plan demands to close the loop of plastics from fishing to ensure sustainable resource management using strategies of the circular economy (CE). Commercial fishing is a crucial sector in Norway, generating 4000 tons of waste plastic annually from fishing gears and ropes. While recycling, landfilling, and incineration are the standard end-of-life management options, the recycling industry in the region is immature. The lack of recycling capacity and inadequate infrastructure results in exporting most of the recyclable fraction out of Norway for further processing. Although within the framework of CE, the transboundary export of waste for recycling misses the opportunity to create value out of waste within the region. Therefore, in the pursuit of CE strategies, it is essential to ensure regional sustainability. In this study, we assess the environmental, economic, and social impacts of landfilling, incinerating, and recycling of waste fishing gears in Norway. To represent the current state, we include two existing recycling scenarios for the assessment, namely, recycling (inland) and recycling (export). Based on qualitative and quantitative data from relevant stakeholders, we adapted multi-criteria decision analysis (MCDA) to rank the end-of-life (EOL) alternatives through their ability to sustainably manage 4000 tons of waste plastics from fishing gears in Norway. The ranking and insights from stakeholder interaction were used to ascertain potential barriers in realizing principles of CE and to further recognize opportunities for establishing circular business models in the region. (C) 2020 The Author(s). Published by Elsevier B.V. [GRAPHICS] .
Circadian transcription factor NPAS2 and the NAD+ -dependent deacetylase SIRT1 interact in the mouse nucleus accumbens and regulate reward

Substance use disorders are associated with disruptions to both circadian rhythms and cellular metabolic state. At the molecular level, the circadian molecular clock and cellular metabolic state may be interconnected through interactions with the nicotinamide adenine dinucleotide (NAD+ )-dependent deacetylase, sirtuin 1 (SIRT1). In the nucleus accumbens (NAc), a region important for reward, both SIRT1 and the circadian transcription factor neuronal PAS domain protein 2 (NPAS2) are highly enriched, and both are regulated by the metabolic cofactor NAD+ . Substances of abuse, like cocaine, greatly disrupt cellular metabolism and promote oxidative stress; however, their effects on NAD+ in the brain remain unclear. Interestingly, cocaine also induces NAc expression of both NPAS2 and SIRT1, and both have independently been shown to regulate cocaine reward in mice. However, whether NPAS2 and SIRT1 interact in the NAc and/or whether together they regulate reward is unknown. Here, we demonstrate diurnal expression of Npas2, Sirt1 and NAD+ in the NAc, which is altered by cocaine-induced upregulation. Additionally, co-immunoprecipitation reveals NPAS2 and SIRT1 interact in the NAc, and cross-analysis of NPAS2 and SIRT1 chromatin immunoprecipitation sequencing reveals several reward-relevant and metabolic-related pathways enriched among shared gene targets. Notably, NAc-specific Npas2 knock-down or a functional Npas2 mutation in mice attenuates SIRT1-mediated increases in cocaine preference. Together, our data reveal an interaction between NPAS2 and SIRT1 in the NAc, which may serve to integrate cocaine's effects on circadian and metabolic factors, leading to regulation of drug reward.
Evaluating the cost and carbon footprint of second-life electric vehicle batteries in residential and utility-level applications

The volume of end-of-life automotive batteries is increasing rapidly as a result of growing electric vehicle adoption. Most automotive lithium-ion batteries (LIBs) are recycled but could be repurposed as second-life batteries (SLBs) since they have 70-80% residual capacity, which can be adequate for stationary applications. SLBs have been proposed as potential, inexpensive, low-carbon energy storage for residential and utility-level applications, with or without photovoltaics (PV). However, it is unknown whether SLBs will be better than new batteries and whether SLBs will provide similar cost and carbon emission reduction for the different stationary applications in all locations. This work compared the levelized cost of electricity and life-cycle carbon emissions associated with using SLBs and new LIBs in the US for three energy storage applications: (1) residential energy storage with rooftop PV, (2) utility-level PV firming, and (3) utility-level peak-shaving, leading to a total of 41 scenarios. SLBs reduced the levelized cost of electricity by 12-57% and carbon emissions by 7-31% compared to new LIBs in the considered applications, with higher reductions for utility-level applications. SLBs still provided benefits at the residential level when compared to rooftop PV alone by reducing the levelized cost by 15-25% and carbon emissions by 22-51%, making SLBs attractive to residential consumers as well. SLBs offer an opportunity to utilize an end-of-life product for energy storage applications, provided the uncertainty in SLB quality and availability is addressed. (C) 2020 Elsevier Ltd. All rights reserved.
The income inequality and carbon emissions trade-off revisited

This paper investigates the marginal effect of income inequality on carbon emissions per-capita. We use a panel consisting of 68 countries over a 50-year period from 1961 to 2010. We report estimates that support the hypothesis that there is a trade-off between carbon emissions per-capita and income inequality. This trade-off is not homogeneous across countries and depends upon the level of development measured by income per-capita. Using panel smooth transition regression, we find that this relationship is negative for countries with low to moderate income per-capita but becomes slightly positive after passing a threshold located around fifteen thousand 2011 US dollars. Moreover, the inequality elasticity of emissions per-capita is comparable in magnitude to its income elasticity. Therefore, both inequality and income levels are crucial to define policies to reduce carbon emissions. This implies a challenge to policymakers who pursue to reduce both income inequality and carbon emissions.
Feasibility analysis of grid-connected and islanded operation of a solar PV microgrid system: A case study of Iraq

Iraq has massive potential for electricity generation from solar energy. Because the country currently suffers from daily electricity shortages, a grid-connected PV system is an unsuitable option since the PV cannot serve the load during the electricity blackouts. This paper aims to analyze the techno-economic and environmental feasibility of a solar PV microgrid system which is able to supply the load during both grid availability and outage periods. A household in Baghdad was selected as a case study. HOMER software was used to carry out the overall analysis using five different control strategies. The results indicated that the most economical configuration was achieved by allowing the grid to charge the batteries at all rates, with a net present cost (NPC) of $29,713. A sustainability assessment revealed that preventing the grid from charging the battery resulted in the highest renewable fraction and the lowest CO2 emissions with 64.9% and 4533 kg/year, respectively. Furthermore, inserting a diesel generator to an economically optimized system was found to reduce the NPC by 11.6%, while increasing the CO2 emissions by 32.7%. This study showed that implementing this sort of project can provide clean, economical, and continuous electricity production in countries with daily blackouts. (C) 2019 Published by Elsevier Ltd.
The reliability, validity and sensitivity of an individualised sub-maximal fitness test in elite rugby league athletes

We aimed to examine the reliability, validity and sensitivity of an individualised sub-maximal fitness test (SMFTIFT60). Nineteen elite rugby league players performed a one-week test-retest of SMFTIFT60. Typical Errors and ICCs were: small (<3.5%) and extremely high (>0.90) for accelerometer-derived variables; moderate (<2.5% points) and moderate to very high (0.71-0.89) for exercise and recovery heart rate (HRex and HRR, respectively). Convergent validity correlations with the 10-week pre-season change in 30-15 Intermittent Fitness Test performance were large for changes in SMFTIFT60 HRex (r = -0.57) and HRR (0.60), and very large for changes in accelerometer measures (range: -0.71 to -0.79). For sensitivity, within-player dose-response relationships between SMFTIFT60 HRex and prior 3-day training loads were negative and ranged from moderate (session ratings of perceived exertion [sRPE-TL], r = -0.34), to large (high-speed running distance, -0.51; acceleration load, -0.73) and very large (heart rate Training Impulse [TRIMP], -0.83). All other relationships were unclear or trivial to small. Physiological and accelerometer-derived measures from the SMFTIFT60 are reliable and valid for the assessment of fitness in rugby league players. Only HRex appears sensitive to acute changes in training load. The SMFTIFT60 could be a useful monitoring tool in team sports.
Export trade, embodied carbon emissions, and environmental pollution: An empirical analysis of China's high- and new-technology industries

China's export trade has been expanding steadily in recent years, significantly increasing resource consumption and environmental pollution. Highand new-technology industries are essential for achieving sustainable economic development and improving environmental quality. This study employs a multi-regional input-output model to estimate the economic benefits and environmental costs of export trade in highand new-technology industries. Then, it analyzes the impact of economic benefits and technological levels on environmental pollution using the Stochastic Impacts by Regression on Population, Affluence, and Technology model. An input-output multi-objective linear programming model and a non-dominated sorting genetic algorithm II are adopted to combine economic development with environmental pollution and determine the optimal path for export trade. The results show that technological progress in China's highand new-technology industries is conducive to reducing embodied carbon emissions in developed countries while increasing emissions in developing countries. Moreover, a nonlinear three-stage accompanying relationship exists between the economic benefits and environmental costs of highand new-technology exports; this is because exports with low economic benefits generate fewer carbon emissions whereas exports with high economic benefits generate significant carbon emissions. An increase in exports with ultra-high economic benefits will generate excessive embodied carbon emissions that hinder coordinated economic-environmental development. Lastly, technological progress in the electrical and optical equipment sector can effectively promote pollution reduction; thus, it should be further developed to improve the comprehensive benefits of exports.