ahmedabdelwahed/Medical_papers_title_and_abstract_NLP_dataset huggingface dataset:
The essential role of fungal peroxisomes in plant infection

Several filamentous fungi are ecologically and economically important plant pathogens that infect a broad variety of crops. They cause high annual yield losses and contaminate seeds and fruits with mycotoxins. Not only powerful infection structures and detrimental toxins, but also cell organelles, such as peroxisomes, play important roles in plant infection. In this review, we summarize recent research results that revealed novel peroxisomal functions of filamentous fungi and highlight the importance of peroxisomes for infection of host plants. Central for fungal virulence are two primary metabolic pathways, fatty acid β-oxidation and the glyoxylate cycle, both of which are required to produce energy, acetyl-CoA, and carbohydrates. These are ultimately needed for the synthesis of cell wall polymers and for turgor generation in infection structures. Most novel results stem from different routes of secondary metabolism and demonstrate that peroxisomes produce important precursors and house various enzymes needed for toxin production and melanization of appressoria. All these peroxisomal functions in fungal virulence might represent elegant targets for improved crop protection.
From physical to ultrasound examination in lymphedema: a novel dynamic approach

In daily practice, medical history and physical examination are commonly coupled with anthropometric measurements for the diagnosis and management of patients with lymphatic diseases. Herein, considering the current progress of ultrasound imaging in accurately assessing the superficial soft tissues of the human body; it is noteworthy that ultrasound examination has the potential to augment the diagnostic process. In this sense/report, briefly revisiting the most common clinical maneuvers described in the pertinent literature, the authors try to match them with possible (static and dynamic) sonographic assessment techniques to exemplify/propose an 'ultrasound-guided' physical examination for different tissues in the evaluation of lymphedema.
Management of traumatic brain injury: a narrative review of current evidence

Globally, approximately 70 million people sustain traumatic brain injury each year and this can have significant physical, psychosocial and economic consequences for patients, their families and society. The aim of this review is to provide clinicians with a summary of recent studies of direct relevance to the management of traumatic brain injury in order to promote best clinical practice. The use of tranexamic acid in the management of traumatic brain injury has been the focus of several studies, with one large randomised controlled trial suggesting a reduction in all-cause mortality within 24 h of injury. The use of therapeutic hypothermia does not improve neurological outcomes and maintenance of normothermia remains the optimal management strategy. For seizure management, levetiracetam appears to be as effective as phenytoin, but the optimal dose remains unclear. There has been a lack of clear outcome benefit for any individual osmotherapy agent, with no difference in mortality or neurological recovery. Early tracheostomy (< 7 days from injury) for patients with traumatic brain injury is associated with a reduction in the incidence of ventilator-associated pneumonia and duration of mechanical ventilation, critical care and hospital stay. Further research is needed in order to determine the optimal package of care and interventions. There is a need for research studies to focus on patient-centred outcome measures such as long-term neurological recovery and quality of life.
Two new eudesmane sesquiterpene glucosides from the aerial parts of Artemisia vulgaris

Using combined chromatographic methods, two new sesquiterpene glucosides, vulgarosides A (1) and B (2), and two known analogs ainsliaside E (3) and pumilaside A (4) were isolated from the aerial parts of Artemisia vulgaris. Their chemical structures were established by spectroscopic methods, including one and two-dimensional nuclear magnetic resonance (1 D and 2 D-NMR) spectroscopy and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). In addition, their cytotoxicity on five human cancer cell lines, including KB (epidermoid carcinoma), HepG2 (hepatocarcinoma), MCF7 (breast carcinoma), SK-Mel-2 (melanoma), and LNCaP (prostate cancer) was also evaluated by the SRB assay. However, none of the tested eudesmane sesquiterpene glycosides showed significant cytotoxicity (IC50>100 µM).
Social Safety of Society for Developing Countries to Meet Sustainable Development Standards: Indicators, Level, Strategic Benchmarks (with Calculations Based on the Case Study of Ukraine)

The paper is devoted to identifying the level of social safety of society, taking into account the indicators of shadow economy, and developing its strategic scenarios as a component of sustainable development of Ukraine by 2030. The authors used the modern methods of normalisation, threshold vector determination, and dynamic weight coefficients in order to identify the level of social safety of society. The authors developed the structure and a list of indicators considering three components of social safety: The standard of living, the demographic component, and the quality of life. This method allows determining the list and severity of threats, comparing the dynamics of integral indices with integral thresholds in one scale, identifying the state of security, and defining strategic goals and strategies. The suggested approach is universal and can be used by any country, region, economic activity, or business to develop evidence-based medium-to-long-term sustainable development scenarios.
Physiology and pathophysiology of human airway mucus

The mucus clearance system is the dominant mechanical host defense system of the human lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid pumping and cough-dependent mechanisms, and mucus transport rates are heavily dependent on mucus concentration. Importantly, mucus transport rates are accurately predicted by the gel-on-brush model of the mucociliary apparatus from the relative osmotic moduli of the mucus and periciliary-glycocalyceal (PCL-G) layers. The fluid available to hydrate mucus is generated by transepithelial fluid transport. Feedback interactions between mucus concentrations and cilia beating, via purinergic signaling, coordinate Na+ absorptive vs Cl- secretory rates to maintain mucus hydration in health. In disease, mucus becomes hyperconcentrated (dehydrated). Multiple mechanisms derange the ion transport pathways that normally hydrate mucus in muco-obstructive lung diseases, e.g., cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), non-CF bronchiectasis (NCFB), and primary ciliary dyskinesia (PCD). A key step in muco-obstructive disease pathogenesis is the osmotic compression of the mucus layer onto the airway surface with the formation of adherent mucus plaques and plugs, particularly in distal airways. Mucus plaques create locally hypoxic conditions and produce airflow obstruction, inflammation, infection, and, ultimately, airway wall damage. Therapies to clear adherent mucus with hydrating and mucolytic agents are rational, and strategies to develop these agents are reviewed.
A population structure-sensitive mathematical model assessing the effects of vaccination during the third surge of COVID-19 in Italy

We provide a non-autonomous mathematical model to describe some of the most relevant parameters associated to the COVID-19 pandemic, such as daily and cumulative deaths, active cases, and cumulative incidence, among others. We will take into consideration the ways in which people from four different age ranges react to the virus. Using an appropriate transmission function, we estimate the impact of the third surge of COVID-19 in Italy. Also, we assess two different vaccination programmes. In one of them, a single shot is administered to all citizens over 16 years old before second shots are available. In the second model, first and second shots are administered to each citizen within, approximately, 20 days of time-gap.
Hymen and virginity: What every paediatrician should know

Paediatricians may face the notion of 'virginity' in various situations while caring for children and adolescents, but are often poorly prepared to address this sensitive topic. Virginity is a social construct. Despite medical evidence that there is no scientifically reliable way to determine virginity, misconceptions about the hymen and its supposed association with sexual history persist and lead to unethical practices like virginity testing, certificate of virginity or hymenoplasty, which can be detrimental to the health and well-being of females of all ages. The paediatrician has a crucial role in providing evidence-based information and promoting positive sexual education to children, adolescents and parents. Improving knowledge can help counter misconceptions and reduce harms to girls and women.
Asymmetric Hydroaminoalkylation of Alkenylazaarenes via Cooperative Photoredox and Chiral Hydrogen-Bonding Catalysis

Chiral hydrogen-bonding (H-bonding) catalytic asymmetric conjugate addition to activated olefins has been widely used to access enantioenriched molecules containing stereocenters at the β-position of the olefin activating groups. Herein, we report the first highly enantioselective radical-based manifold. Under a dual organocatalyst system involving a chiral phosphoric acid and DPZ as the photoredox sensitizer, transformations of N-arylglycines, in which aryls with CF3 substituents are introduced, with alkenyl azaarenes afforded valuable hydroaminoalkylation adducts with satisfactory results. In addition to the diversity of azaarenes, the method can be used to construct aryl-, alkyl- and silyl-substituted stereocenter. Control experiments and density functional theory calculations were performed to elucidate a plausible reaction mechanism and the origin of stereoselectivity, wherein nonclassical H-bonding interactions were found to assist chiral catalysts in offering sufficient enantiocontrol.
Assessment of tumor burden and response to therapy in patients with colorectal cancer using a quantitative ctDNA test for methylated BCAT1/IKZF1

Failure of colorectal cancer (CRC) treatment is due to residual disease, and its timely identification is critical for patient survival. Detecting CRC-associated mutations in patient circulating cell-free DNA is confounded by tumor mutation heterogeneity, requiring primary tumor sequencing to identify relevant mutations. In this study, we assessed BCAT1 and IKZF1 methylation levels to quantify circulating tumor DNA (ctDNA) and investigated whether this method can be used to assess tumor burden and efficacy of therapy. In 175 patients with CRC who were ctDNA-positive pretreatment, ctDNA levels were higher with advancing stage (P < 0.05) and correlated with tumor diameter (r = 0.35, P < 0.001) and volume (r = 0.58, P < 0.01). After completion of treatment (median of 70 days [IQR 49-109] after surgery, +/- radiotherapy, +/- chemotherapy), ctDNA levels were reduced in 98% (47/48) and were undetectable in 88% (42/48) of patients tested. For those with incomplete adjuvant chemotherapy after surgery, roughly half remained ctDNA-positive (11/21, 52.4%). The presence of ctDNA after treatment was associated with disease progression (HR 9.7, 95%CI 2.5-37.6) compared to no ctDNA. Assaying blood for ctDNA methylated in BCAT1/IKZF1 has the potential for identifying residual disease due to treatment failure, informing a potential need for therapy adjustment in advanced disease.
Medullary bone in male budgerigars ( Melopsittacus undulatus) with testicular neoplasms

Medullary bone is a calcium-rich, labile bone normally occurring in female birds with each egg-laying cycle. The stimulus for formation of medullary bone is, in part, the cyclic increase in serum estrogens produced by preovulatory ovarian follicles. Increased bone density due to formation of medullary bone, particularly in pneumatic bones, has been termed polyostotic hyperostosis, even if physiologic. This study investigated the formation of medullary bone in nonpneumatic (femur) and pneumatic (humerus) bones in sexually mature male budgerigars submitted for autopsy. Of the 21 sexually mature male budgerigars submitted for autopsy, 7 (33%) had medullary bone in 1 or more bones examined. All 7 male budgerigars with medullary bone had a testicular neoplasm, which was morphologically consistent with a testicular sustentacular cell tumor, seminoma, or interstitial cell tumor. Medullary bone was not present in the 14 cases with other diseases. Medullary bone formation in pneumatic and nonpneumatic bones can occur in male budgerigars with testicular neoplasms. Radiographic increases in medullary bone density, particularly in the humerus, could provide antemortem indication of testicular neoplasia in male budgerigars.
Removal of volatile organic compounds (VOCs) emitted from a textile dyeing wastewater treatment plant and the attenuation of respiratory health risks using a pilot-scale biofilter

The textile dyeing is a significant worldwide economic pillar of the industry mainstay of the region's industrial economy. Therefore, significant attention should be paid to its emitted volatile organic compounds (VOCs) regarding their potential adverse effects on ecosystems and human health. In this study, a spray tower (ST) (preferential elimination of hydrosoluble VOCs) and biofilter (primary removal of particle-free VOCs) were used in combination. Three techniques, including gas chromatography-mass spectrometer (GC-MS), e-nose, and Proton transfer reaction time-of-flight mass spectrometry (PTR-TOF-MS) were used to accurately identify the associated VOCs profile. In total, 50 types of VOCs, with total concentrations ranging from 1.26 to 2.79 mg M-3, were detected from the outlet of the TDWTP over a 90-day treatment period. The highest level occurred for nitrogen- and oxygen-containing compounds (NAOCCs), followed by aliphatic hydrocarbons (AIHs), aromatic hydrocarbons (AHs), and halogenated hydrocarbons (HHs). Average removal efficiencies (REs) of the four studied VOC groups (NAOCCs, AIHs, AHs, and HHs) were 66.7%, 67.9%, 11.7%, and 52.1%, respectively. Proteobacteria dominated the biofilter, followed by Actinobacteria, Firmicutes, and Bacteroidetes. A positive correlation was observed between the relative abundance of Proteobacteria and the RE of NAOCCs, with RE significantly increased from 38.1% (day 1) to 83.2% (day 90). The degradation of these organic pollutants, such as NAOCCs, may be mainly performed by the dominant genus, such as Acidithiobacillus and Metallibacterium, as predicted by PICRUSt. A respiratory health risk evaluation demonstrated that the cancer and non-cancer risks of typical VOCs were dramatically reduced after the above-mentioned purification. The combined results indicate that the ST-biofilter is an efficient approach for the end-of-pipe treatment of exhausted gas in TDWTP and helps attenuate human health risk. (C) 2020 Elsevier Ltd. All rights reserved.
Estimating health burden and economic loss attributable to short-term exposure to multiple air pollutants in China

Existing studies focused on the evaluation of health burden of long-term exposure to air pollutants, whereas limited information is available on short-term exposure, particularly in China. Air pollutant concentrations in 338 Chinese cities in 2017 were used to estimate the air pollutants related health burden which was defined as premature mortalities from all-cause, cardiovascular and respiratory disease as well as hospital admissions for cardiovascular and respiratory disease. Log-linear model was used as the exposure-response function to estimate the health burden attributable to each air pollutant. The value of statistical life and cost of illness methods were used to estimate economic loss of the premature mortalities and hospital admissions, respectively. The national all-cause premature mortalities attributable to all air pollutants was 1.35 million, accounting for 17.2% of reported deaths in China in 2017. Among all-cause premature mortality, contributions of PM2.5, PM2.5-10, NO2, SO2, O-3 and CO werel 11.1%, 5.2%, 28.9%, 9.6%, 23.0%, and 22.2%, respectively. The national cardiovascular and respiratory premature mortalities were 0.77 and 0.21 million, respectively. About 7.8 million cardiovascular and respiratory disease hospital admissions were attributed to short-term exposure to all air pollutants. The economic loss of the overall health burden (premature mortality and hospital admissions) was 2065.54 billion Yuan, which was equivalent to 2.5% of the national GDP in 2017. The health burden and economic loss attributable to short-term exposure to ambient air pollutant are substantial in China. It suggested that the adverse health effects attributable to short-term exposure to air pollutant should not be neglected in China. In order to reduce the health impact of air pollution, each city should develop air pollution prevention and control measures based on existing scientific evidence.
Techno-economic optimization analysis of stand-alone renewable energy system for remote areas

Hybrid renewable energy systems (HRES) are becoming popular as stand-alone power systems for providing electricity in remote areas due to the advancement in renewable energy technologies and subsequent rise in the prices of conventional fuels. A hybrid energy system, or hybrid power, usually consists of two or more renewable energy sources used together to provide increased system efficiency as well as greater balance in energy supply. Therefore, this paper aims at the design optimization of the hybrid renewable energy systems to meet the specific daily residential load profile for remote areas. The optimization problem regarding the design of a hybrid renewable energy system has been solved using Homer Pro Software depending on demand-side management during peak and off-peak hours. Four cases are used to evaluate the performance of the proposed design scheme. The simulation results have shown that the proposed design scheme is suitable for remote areas in comparison to the earlier proposed systems depicted in four cases. In addition, a properly planned hybrid system with demand-side management will reduce the overall system cost and increase the system efficiency by reducing carbon emissions, balancing power system by managing overloading and reduction in load shedding as well as less complex design and easy implementation in remote areas.
Efficient irrigation water allocation and its impact on agricultural sustainability and water scarcity under uncertainty

Agriculture is a key economic sector in developing countries that are facing challenges of low efficiency of water resources utilization and of shrinking water supply. This study develops an optimization model for the allocation of agricultural irrigation water to improve irrigation water use efficiency (IWUE), considering uncertainties of fluctuating water supply. Then, it assesses the impact of efficient water allocation on the sustainability and water scarcity under different levels of water supply. This study can help answer questions as to how to optimal allocate limited water supplies to different crops and different subareas under uncertainty to improve IWUE, how water shortage affects economic, social, and environmental aspects, and what the relationship between system sustainability and water shortage is. To demonstrate its feasibility, the proposed models are applied to an irrigation district in northeastern China. These models can also be applied to other regions that suffer from water scarcity. Results of application are found to be satisfactory for explaining the impact of agricultural irrigation water allocation on net economic benefit, water resources allocation equity, total greenhouse gas emissions, and water scarcity footprint under different water supply conditions. This study provides insights into tradeoffs amongst resources, economy, society, and environment in irrigated agricultural systems under uncertainty.
Soybean Meal Extract Preserves Memory Ability by Increasing Presynaptic Function and Modulating Gut Microbiota in Rats

Age-related degenerative brain diseases frequently manifest as memory deficits. Dietary interventions or nutraceuticals may provide efficacious treatments through prevention and cure. Soybean meal, a byproduct of soy oil refining, has health benefits, but its effect on memory function is unknown. Therefore, we evaluated the effect of the oral administration of soybean meal extract (SME) for 2 weeks on memory function using the Morris water maze (MWM) test in healthy rats and investigated the possible underlying mechanisms. First, analysis of the composition revealed that SME is rich in isoflavones; SME did not exhibit hepatotoxicity or renal toxicity at the different doses tested. The MWM results revealed that the escape latency and movement distance of rats were significantly shorter in the SME group than in the control group, indicating that SME can help in memory preservation. In addition, SME increased the levels of presynaptic proteins such as synaptophysin, synaptobrevin, synaptotagmin, syntaxin, synapsin I, and 25-kDa synaptosome-associated protein as well as protein kinases and their phosphorylated expression, including extracellular signal-regulated kinases 1 and 2 (ERK1/2), protein kinase C (PKC), and Ca2+/calmodulin-dependent protein kinase II (CaMKII) in the hippocampal nerve terminals (synaptosomes). Transmission electron microscopy also indicated that SME increased the number of synaptic vesicles in hippocampal synaptosomes. Furthermore, SME rats exhibited altered microbiota composition compared with control rats. Therefore, our data suggest that SME can increase presynaptic function and modulate gut microbiota, thus aiding in memory preservation in rats.
Assessment of drug-drug interactions of CC-90001, a potent and selective inhibitor of c-Jun N-terminal kinase

CC-90001 is predominantly metabolised via glucuronidation, while oxidative metabolism is a minor pathway in human hepatocytes and liver microsomes. In vitro, CC-90001 glucuronidation was catalysed by UGT1A9, UGT1A4, and UGT1A1, while oxidative metabolism was primarily mediated by CYP3A4/5 with minor contributions from CYP1A2, CYP2C9, CYP2B6, and CYP2D6.CC-90001 in vitro inhibits CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, and CYP3A4 ≤ 55% at 100 μM, and the inhibition was negligible at ≤30 μM. CC-90001 is not a time-dependent CYP inhibitor.In human hepatocytes CC-90001 is an inducer of CYP2B6 and CYP3A, with mRNA levels increased 34.4% to 52.8% relative to positive controls.In vitro CC-90001 is a substrate of P-gp, and an inhibitor of P-gp, BCRP, OAT3, OATP1B1, OATP1B3, OCT2, MATE1, and MATE2k with IC50 values of 30.3, 25.8, 17.7, 0.417, 19.9, 0.605, 4.17, and 20 μM, respectively.A clinical study demonstrated that CC-90001 has no or little impact on the exposure of warfarin (CYP2C9), omeprazole (CYP2C19), midazolam (CYP3A) or metformin (OCT2, MATE1/2k). CC-90001 co-administration increases the AUCt and Cmax 176% and 339% for rosuvastatin (BCRP/OATP1B1/3), 116% and 171% for digoxin (P-gp), and 266% and 321% for nintedanib (CYP3A & P-gp), respectively.In conclusion, CC-90001 in unlikely to be a victim or perpetrator of clinically relevant interactions involving CYPs or UGTs. Weak to moderate interactions are expected in clinic with substrates of P-gp and OATP1B1 due to CC-90001 inhibition of these transporters.