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A case-control study of a benign electroencephalographic variant pattern. | Wicket spikes (WS) are a benign electroencephalogram (EEG) variant; seen mainly in adults; during somnolence; in the temporal regions; in many clinical situations. WS can appear in trains or isolatedly; sometimes being difficult to differentiate from epileptiform activity. We reviewed 2;000 EEG's; found 65 with WS (3.25%) and compared them with 65 normal EEG without WS. There was statistically significant (SS) association between WS and age over 33; adolescent age was correlated to absence of WS and age ove | 10667277 | [
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A case-control study of a benign electroencephalographic variant pattern. | r 65; to the presence of WS; there was an inverse correlation between WS and epilepsy; related to differences in age; a SS association with cerebrovascular disorders disappeared after controlling for age; a SS correlation with headache was also related to age; female predominance was not SS. There was a great variety of clinical situation associated with WS. We conclude that WS are a inespecific normal variant of the EEG that is age-related. | 10667277 | [
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Continuous spike-waves during slow waves sleep. A clinical and electroencephalographic study in fifteen children. | We report on the clinical and EEG features of 15 patients with the syndrome of "continuous spike waves during slow wave sleep" (CSWSS). The differential diagnosis of CSWSS includes benign epilepsy of childhood with centro-temporal spikes; and Landau-Kleffner and Lennox-Gastaut syndromes. We found normal CT and MRI features in 6 cases; periventricular leukomalacia with and without diffuse brain atrophy in 4 cases and hydrocephalus in 1 case. There was no association between specific neurological findings and | 10667278 | [
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Continuous spike-waves during slow waves sleep. A clinical and electroencephalographic study in fifteen children. | CSWSS. Nine of our cases had relatively focal discharges; like some cases from the literature. The occurrence of CSWSS appears to be age-related; generally between the ages of 5 to 12 years; with a strong temporal relation to the neuropsychological deterioration in its nature; severity and prognosis. We believe that this striking disorder has been overlooked and that routine sleep EEG studies on epileptic children may disclose additional cases of CSWSS. | 10667278 | [
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[Video-polygraphic-EEG study in the full-term newborn with low birthweight for their gestational age]. | Video-polygraphic-EEG studies were performed in the first 24 life-hours of 26 healthy full-term newborns without perinatal injuries. The neurological examination and cranial ultrasonography were normal. The newborns were divided into two groups: one; with full-term appropriate--birth weight 11 newborns (control group) and the other with full-term low-birth weight 15 newborns. Thirteen newborns of the second group had video-polygraphic-EEG study abnormalities. The most frequent abnormalities were found in 11 | 10667279 | [
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[Video-polygraphic-EEG study in the full-term newborn with low birthweight for their gestational age]. | cases; as far as sleep architecture is concerned. Also; when compared with the control group; 8 cases of an excessive amount of startles and 2 cases of low behavior activities were found. The results demonstrate the usefulness of video-polygraphic-EEG study in the full-term newborns with intra-uterine growth retard. This examination was sensitive to detect behavior; sleep architecture and EEG standard differences in the low birth-weight newborns as to the control group. | 10667279 | [
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[Electroencephalographic modification in Down syndrome]. | The frequency of epilepsy in Down syndrome (DS) has been reported in literature varying from 6 to 17%. A typical electroencephalographic (EEG) pattern has not been established for this condition. There is a great variation on EEG abnormalities and most of them are not associated to behavior alterations or neurological signs. The aim of this study was to establish epidemiological and electroencephalographic parameters in institutionalized patients with clinical diagnosis of DS. We studied 77 individuals of b | 10667280 | [
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[Electroencephalographic modification in Down syndrome]. | oth sexes; age ranging from 0-38 years old. The EEG was performed on all the patients; 20.7% had EEG abnormalities and 31.3% of these were epileptic. The non-epileptic patients presented inespecific EEG abnormalities. Therefore; our data did not allow us to propose a typical EEG pattern for DS. | 10667280 | [
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[Cerebrovascular disease in children: I. Epileptic manifestations]. | Seizures may occur as a complication of cerebrovascular disease (CVD) and its prevalence; clinical presentation; risk factors and evolution have been reported by few authors. We evaluated 39 children with CVD and analyzed the association with seizures. Seizures occurred in 24 (61.5%) patients and were classified as partial (29.2%); generalized (54.2%) and secondarily generalized (16.6%). Infants had a significantly higher prevalence of seizures (p = 0.0362) than children at other ages. Cortical localization | 10667281 | [
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[Cerebrovascular disease in children: I. Epileptic manifestations]. | was associated with a significantly higher prevalence of seizures (p = 0.0101). There were no differences between ischemic and hemorrhagic strokes. Fourteen patients had no seizures after the acute phase of the CVD; the 2 previously epileptic patients had their seizures controlled with antiepileptic drugs; 3 developed epilepsy; 2 died during the acute phase and in 3 patients there was not enough time yet to make a clear diagnosis of epilepsy. | 10667281 | [
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[Cerebrovascular disease in children: II. Clinical aspects in 42 cases]. | We report the findings recorded in 42 children suffering cerebrovascular disease and assisted at the Hospital das Clínicas FCM-UNICAMP; over a 8 years period (January 1990 until April 1998). The ischemic type was the most common; and involvement of the middle cerebral artery; sudden onset of clinical manifestation with seizures and motor disability were more common in early aged children. Motor sequelae predominated in the follow-up of these children. | 10667282 | [
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[Use of amitriptyline in attention deficit hyperactivity disorder]. | We studied the action of amitriptyline (AMI) in the attention deficit hyperactivity disorder (ADHD). Twenty-five children who came to consultation for ADHD were analyzed; in two groups: the group which used AMI (n = 18) at 1.6 mg/kg/day and the group which used placebo (n = 7). Both groups were submitted to two assessments in a 30 days interval; which consisted of the evolutive neurological evolution examination (ENE) and the WISC scale subtests on numbers; drawings to be completed and the code. The results | 10667283 | [
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[Use of amitriptyline in attention deficit hyperactivity disorder]. | showed that the AMI produced an improvement in performance in the motor persistence tests. | 10667283 | [
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[Intravenous lysine clonixinate for the treatment of migraine: an open pilot study]. | Several oral nonsteroidal anti-inflammatory drugs (NSAID) are effective to treat migraine attacks. Despite its efficacy to treat migraine and other pain; there are a few commercial NSAIDs available for intravenous (i.v.) administration. Lysine clonixinate (LC) is a NSAID derived from nicotinic acid that has been proven effective in various algic syndromes such as renal colic; nerve compression; muscular pain and odontalgias. The aim of this study was to evaluate the efficacy of the i.v. LC in the treatment | 10667284 | [
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[Intravenous lysine clonixinate for the treatment of migraine: an open pilot study]. | of severe attacks of migraine. We studied prospectively 19 patients; 17 women and 2 men; ages from 18 to 57 years; with the diagnosis of migraine according to the International Headache Society criteria. The patients were oriented to proceed to the clinic once the headache has started; and were placed under an i.v. infusion of LC and saline in a superficial vein of the forearm; once the intensity reached severe. Evaluating the headache intensity after 30; 60 and 90 minutes; as well as the presence of side e | 10667284 | [
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[Intravenous lysine clonixinate for the treatment of migraine: an open pilot study]. | ffects; we observed that all of the 19 patients were headache free after 90 minutes. Some patients presented mild adverse effects and the vital signs were not significantly affected. We then concluded that the i.v. infusion of the NSAID LC (2-3-chloro-o-toluidin)piridin-3-lysine carboxilate); a derived from the nicotinic acid with a chemical structure that resembles the flufenamic acid; was efficient abolishing a severe migraine attack after 90 minutes in 19 patients. Controlled studies with a double-blind | 10667284 | [
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[Intravenous lysine clonixinate for the treatment of migraine: an open pilot study]. | and randomized design; and treating a greater number of patients and attacks are necessary to confirm these initial observations. | 10667284 | [
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[Clinical and therapeutical features in 135 patients with dystonia: experience of movement disorders unity of the Hospital de Clínicas of the Universidade Federal do Paraná]. | This study aims to describe the clinical patterns and therapeutic responses in 135 patients with dystonia. According to the classification; 54% were focal; 17.8% were segmental; 8.1% hemidistonia; 18.6% generalized and 1.5% were multifocal. There was a positive familial history in 5.9% of the cases. The treatment of the idiopathic dystonias is divided in: specific and symptomatic; and it can be local with botulinum toxin; or systemic with oral drugs. The most common drugs used in the treatment were antichol | 10667285 | [
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[Clinical and therapeutical features in 135 patients with dystonia: experience of movement disorders unity of the Hospital de Clínicas of the Universidade Federal do Paraná]. | inergics and benzodiazepines; with poor responses in the generalized forms. Botulinum toxin A was the first line treatment for focal and segmental forms of dystonia. Meanwhile; the generalized forms of dystonia show poor response to the therapies utilized. | 10667285 | [
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[Image guided stereotactic approach of central nervous system lesions: accuracy, morbidity, mortality]. | We studied seventy-five patients with brain lesions biopsied by stereotaxis from March 1993 to December 1998 at Universidade Federal de São Paulo-Escola Paulista de Medicina. The three most frequent lesions were: metastasis; low grade astrocytomas and glioblastoma multiforme. The morbidity rate was 2.66% due to: one case of scalp infection in a patient with thalamic cyst; and a partial seizure during surgery in a patient with lymphoma. The mortality rate was 1.33% due to increasing of cerebral edema after b | 10667286 | [
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[Image guided stereotactic approach of central nervous system lesions: accuracy, morbidity, mortality]. | iopsy and the patient died after one week. The diagnostic accuracy was 89.33%. | 10667286 | [
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[An en bloc cranio-orbitozygomatic approach: surgical technique and results]. | An en bloc cranio-orbitozygomatic approach is described. This technique was applied in seven patients (five basilar artery aneurysms; a trigeminal neuroma; a meningioma of the lesser sphenoid wing). The follow-up period ranged from 3 to 50 months. The patients were retrospectively analyzed from the cosmetic point of view; and submitted to computerized tomography with three dimensional and multiplanar reconstructions. The access provided a wider operative field with a shorter distance to the pathology and po | 10667287 | [
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[An en bloc cranio-orbitozygomatic approach: surgical technique and results]. | ssibility of increased angulation of the microscope. The aneurysms could be clipped and the tumors completely removed in all cases. A frontalis muscle paralysis occurred in two cases; as well as a temporalis muscle atrophy in another two patients. There were no enophthalmos or bone flap displacements. The surgical technique is simple and do not require drills; electric saws and mini-plates. | 10667287 | [
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[Stereotactic implantation of depth electrodes by magnetic resonance image in epilepsy surgery]. | We present the case of a 40-year-old woman with refractory epilepsy since aged 18; who was submitted to video-EEG monitoring with intracerebral depth electrodes. The clinical history and examination; magnetic resonance image (MRI); video-EEG and neuropsychological study did not allow the determination of the cerebral onset of epileptic seizures. Depth electrodes inserted by MRI-guided stereotaxis allowed the recording of the epileptic activity and thus showed quite accurately the area of the brain to be sur | 10667288 | [
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[Stereotactic implantation of depth electrodes by magnetic resonance image in epilepsy surgery]. | gically resected. She underwent a right anterior temporal lobectomy with amygdalohippocampectomy. The immediate postoperative period was uneventful and she is without epileptic seizures after three months of follow-up. The average pre-operative free-seizure period was two weeks. To our knowledge; this is the first stereotactic surgery for insertion of depth intracerebral electrodes in epilepsy in Brazil. | 10667288 | [
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Secondary bilateral synchrony due to fronto-mesial lesions. An invasive recording study. | Frontal lobe epilepsies may present difficulties in focus localization in the pre-operative work-up for epilepsy surgery. This is specially true in patients with normal MRIs. We report on a 16 years-old girl that started with seizures by the age of 8 years. They were brief nocturnal episodes with automatisms such as bicycling and boxing. Seizure frequency ranged from 4-10 per night. Scalp EEG showed few right frontal convexity spiking and intense secondary bilateral synchrony (SBS). High resolution MRI dire | 10667289 | [
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Secondary bilateral synchrony due to fronto-mesial lesions. An invasive recording study. | cted to the frontal lobes was normal. Ictal SPECT suggested a right fronto-lateral focus. Ictal video-EEG showed no focal onset. She was submitted to invasive recordings after subdural plates implantation. Electrodes covered all the frontal convexity and mesial surface bilaterally. Ictal recordings disclosed stereotyped seizures starting from the right mesial frontal. Using a high-resolution tool to measure intra and interhemispheric latencies; the timing and direction of seizure spread from the right front | 10667289 | [
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Secondary bilateral synchrony due to fronto-mesial lesions. An invasive recording study. | o-mesial region were studied. Motor strip mapping was performed by means of electrical stimulation. She was submitted to a right frontal lobe resection; 1.5 cm ahead of the motor strip and has been seizure free since surgery (8 months). Pathological examination found a 4 mm area of cortical dysplasia. Invasive studies are needed to allow adequate localization in patients with non-localizatory non-invasive work-up and may lead to excellent results in relation to seizures after surgery. | 10667289 | [
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[Septic thrombosis of cavernous sinus: report of 6 cases]. | The cavernous sinus is most frequently involved by septic thrombosis. The common sites of primary infection are the medial face; orbits; tonsils; soft palate; sphenoid and ethmoid sinuses. The usual clinical presentation begins with fever and periorbital edema followed by headache; ptosis and ocular muscles palsy. The diagnosis is usually made on clinical grounds. Treatment consists of eradication of the primary source of infection and the administration of antibiotics and anticoagulants. We report six case | 10667290 | [
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[Septic thrombosis of cavernous sinus: report of 6 cases]. | s of septic thrombosis of cavernous sinus. | 10667290 | [
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[Prognosis factors in cryptococcal meningoencephalitis]. | To identify demographic; clinical and cerebrospinal fluid (CSF) variables associated to intrahospitalar lethality of patients with cryptococcal meningoencephalitis.Retrospective cohort to study prognosis.Hospital Couto Maia (HCMaia) reference for patients with infectious diseases in the State of Bahia Northeastern Brazil.Patients admitted at HCMaia; from 1972 to 1996; with the diagnosis of cryptococcal meningoencephalitis.Lethality rate was 42.7%. The most important neurological abnormalities were neck stif | 10667291 | [
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[Prognosis factors in cryptococcal meningoencephalitis]. | fness; decreased consciousness level; behavior changes; cranial nerve palsy and visual alteration. Disease time over 30 days; involvement of consciousness level and cerebrospinal fluid cells under 40/mm3 were associated to a higher lethality rate.Disease time over 30 days; involvement of consciousness level; and CSF decreased cellularity were the only predictors of lethality in the studied population. | 10667291 | [
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[Clinical manifestations in patients with computerized tomography diagnosis of neurocysticercosis]. | A survey was conducted in the urban area of Lages using patients who had been submitted to a computed tomography of the skull in the period of March-December; 1996; for different reasons. Forty-two patients with a provisional diagnosis of neurocysticercosis; and 57 negatives were personally interviewed by one of the authors (Pfuetzenreiter); using a semi-structured procedure. More individuals with a provisional diagnostic of neurocysticercosis reported clinical manifestations related to this infection than | 10667292 | [
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[Clinical manifestations in patients with computerized tomography diagnosis of neurocysticercosis]. | those found negative. This difference is more marked among women; except in relation to convulsions; more frequently reported by men (19.05%) than by women (7.14%). The greater percentage of inactive forms (83.33%) and a longer history of perceived symptoms among those positives suggest that the condition is not new. | 10667292 | [
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[True neurogenic outlet syndrome: report of 2 cases]. | True neurogenic thoracic outlet syndrome is caused by compression of the lower trunk of the brachial plexus usually by a cervical rib; fibrous band or an elongated transverse process of C7. We describe two cases of female patients (23 and 19 years old) with pain in the right superior limb and progressive muscular weakness and atrophy of the intrinsic muscles of hand. Electrodiagnostic studies showed reduced amplitude of compound muscle action potential of median nerve and decreased amplitude of ulnar sensor | 10667293 | [
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[True neurogenic outlet syndrome: report of 2 cases]. | y nerve action potential. Motor and sensory nerve conduction velocities were normal in both patients. Needle electromyography were findings compatible with chronic denervation in the intrinsic muscles of the right hand of both patients. Radiological investigation showed cervical ribs in one case and elongated transverse process of C7 in the other. A discussion about the clinical and electrophysiological features and the treatment of the syndrome was performed. | 10667293 | [
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[Type I Chiari malformation: report of 2 cases with unusual clinical presentation]. | We describe two patients with Chiari type I malformation with unusual clinical presentation. The first one with clinical picture of acute respiratory insufficiency and the second one with vestibular and mild cerebellar syndrome and headache. In both cases the neurological examination demonstrated the presence of "down-beating nystagmus". We emphasize the value of neurological semiology; determining a correct complementary evaluation and effective treatment. | 10667294 | [
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Walker-Warburg syndrome. Report of two cases. | The purpose of this study is to describe two infants that were diagnosed with Walker-Warburg syndrome (WWS); a rare form of congenital muscular dystrophy (CMD). They were studied in their clinical; laboratory; and neuroradiologic features. The index case had a brain magnetic resonance imaging (MRI) and the second patient had a head computerized tomography (CT). In addition; a literature review was performed to describe the main forms of CMD. The index case fulfilled all criteria for WWS. A brain MRI perform | 10667295 | [
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Walker-Warburg syndrome. Report of two cases. | ed at age 4 months served to corroborate the clinical diagnosis; showing severe hydrocephalus; type II lissencephaly; cerebellar vermian aplasia; and a hypoplastic brain stem. The authors were able to establish a retrospective diagnosis of WWS in the index case's older sister; based upon her clinical picture and head CT report. | 10667295 | [
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Pseudocystic form of neurocryptococcosis in pregnancy. Case report. | We report a case of neurocryptococcosis which is unique in the literature because the patient had a pseudocystic form of the disease during pregnancy and without any evidence of AIDS. The clinical picture was that of intracranial hypertension and the epidemiological background was highly suggestive of cysticercosis. CT showed multiple round hypodense lesions in the basal ganglia and cerebellum; without contrast enhancement. Since a scolex was not visible; the diagnosis of neurocysticercosis was considered p | 10667296 | [
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Pseudocystic form of neurocryptococcosis in pregnancy. Case report. | robable. CSF examination was not performed in view of its high risk. The patient had progressive downhill course. Autopsy disclosed multiple gelatinous pseudocysts in the cerebral and cerebellar gray matter; containing abundant Cryptococcus neoformans. Meningeal involvement was minimal. The child was delivered by caesarean section and was free of infection; but died later of hyaline membrane disease. The neuroimaging appearances of this rare instance of the pseudocystic form of neurocryptococcosis mimicked | 10667296 | [
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Pseudocystic form of neurocryptococcosis in pregnancy. Case report. | closely neurocysticercosis and only postmortem examination allowed correct diagnosis. The pseudocystic form has so far only been reported in AIDS. | 10667296 | [
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Treatment of cervical dystonia with botulinum toxin in a patient with myasthenia gravis. | We report the case of a 49-year-old woman who has the rare combination of myasthenia gravis and cervical dystonia. She was treated with botulinum toxin type A with good response and no evidence of deterioration of the myasthenic symptoms. We therefore conclude that it is possible to use botulinum toxin in the presence of defective neuromuscular transmission. | 10667297 | [
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[Identical twins discordant for Cushing's disease: case report[]. | Cushing's disease is rare in children and its occurrence in identical twins is extremely rare. This paper reports on identical twins discordant for Cushing's disease. One of them first presented with a cushingoid phenotype by the age of 10. Her evaluation showed an increased urinary free-cortisol and serum ACTH. Her pattern in the dexametazone suppression tests was compatible with Cushing's disease. MRI disclosed a pituitary macroadenoma which was removed by the transesphenoidal approach. Immunohistochemica | 10667298 | [
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[Identical twins discordant for Cushing's disease: case report[]. | l studies of the tumor showed the presence of ACTH-producing cells. The patient went into clinical and laboratorial remission after surgery. She re-started to grow after the disappearance of the Cushing's phenotype but she is still shorter than her healthy sister. The latter remains disease-free 4 years after her sister's diagnosis. This represents the third such case reported in the literature. Our findings suggest that acquired factors may be responsible for the genesis of Cushing's disease. | 10667298 | [
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[Actinomycosis of the brain: case report]. | Actinomycosis located in the central nervous system is an extremely uncommon event; but if correctly diagnosed and properly treated may have a good prognosis. This case report of a cerebral abscess caused by actinomyces suggests that such a rare event should be included in the differential diagnosis of infectious diseases that affect the central nervous system. | 10667299 | [
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[Emotionally-loaded narrative increases dyslogia in schizophrenics]. | We tested the degree of dyslogia in the narrative of ten schizophrenic non-medicated outpatients while they narrated emotionally-loaded or neutral facts. The "emotional narratives" were much more dyslogic than the "neutral narratives". In order to explain these facts we evoke: 1. A fronto-temporo-limbic connection dysfunction would disturb an adequate cognitive treatment of emotions that would be; in this way; highly disruptive over logical processes. 2. A working memory/supervisory attentional system dysfu | 10667300 | [
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[Emotionally-loaded narrative increases dyslogia in schizophrenics]. | nction that would produce both a loss of the normal connections among the fragments of speech and a lack of global strategical planning of the thought. | 10667300 | [
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Sex playing with the mind. Effects of oestrogen and testosterone on mood and cognition. | Women now spend more than 1/3 of their lives in a state of oestrogen deprivation as a result of increased life expectancy. A similar; but milder; hypogonadal state has been described for elderly men. This paper aims to review the available literature on the effects of both oestrogen and testosterone on mood and cognition. Oestrogen replacement therapy of postmenopausal women is associated with improvements in measures of well being and decline in depression scores. In addition; oestrogen seems to augment th | 10667301 | [
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Sex playing with the mind. Effects of oestrogen and testosterone on mood and cognition. | e response of postmenopausal women with major depression to antidepressant treatment. Most studies designed to investigate the impact of oestrogen on cognition indicate that replacement therapy is associated with better performance on neuropsychological tests; particularly in measures of verbal memory and fluency. The data also supports claims that oestrogen replacement therapy reduces the risk of Alzheimer's disease in later life and improves response of patients to anticholinesterase treatment. Data on th | 10667301 | [
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Sex playing with the mind. Effects of oestrogen and testosterone on mood and cognition. | e effects of testosterone is sparser. Preliminary findings suggest that testosterone therapy may improve mood when used in isolation or in association with oestrogen. The effects of testosterone on cognitive functioning are less clear--some studies indicate that the administration of testosterone to non-demented subjects is associated with better visuospatial functioning and deterioration of verbal skills. In summary; gonadal hormones seem to modulate various aspects of mental functioning. If future studies | 10667301 | [
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Sex playing with the mind. Effects of oestrogen and testosterone on mood and cognition. | prove this to be true; hormone replacement therapy should have a major impact on the physical and mental health of older people in the years to come. | 10667301 | [
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Eicosanoid metabolism in human platelets is modified by albumin. | nan | 10667305 | [
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Diverse functional coupling of prostanoid biosynthetic enzymes in various cell types. | As also detailed in our accompanying papers in this issue; recent studies have revealed functional crosstalk and segregation between PLA2s; COXs; and terminal PG synthases in various cells (Table I). Among the PLA2s; cPLA2 is required for all three responses; and sPLA2-IIA augments the delayed response in preference to the immediate response. sPLA2-IIA associates with proteoglycans on the surface of stimulus-primed cells to exert its functions. COX-1 is utilized only in the immediate response and COX-2 is a | 10667306 | [
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Diverse functional coupling of prostanoid biosynthetic enzymes in various cell types. | prerequisite for the delayed response. The induced immediate response is often mediated by COX-2 rather than by COX-1; especially when the end product is PGE2. In addition to segregated utilization of these enzymes; significant crosstalk and/or synergism between them; which is often cell type specific; is also obvious. For instance; sPLA2 acts as an enhancer of COX-2 expression in rat mast cells; functional cPLA2 is required for sPLA2 induction in rat fibroblasts; and sPLA2 augments cPLA2 and COX-2 express | 10667306 | [
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Diverse functional coupling of prostanoid biosynthetic enzymes in various cell types. | ion in mouse osteoblasts via endogenous PGE1. Moreover; differential coupling between COXs and downstream terminal PG synthases is also evident in macrophages; in which COX-1 and COX-2 are preferentially coupled with TXS and PGES; respectively. Thus; different PG-biosynthetic enzymes; acting on different cellular AA pools at different locations and being regulated by separate but interacting mechanisms; confer on the system great versatility in ensuring that both immediate and delayed AA-derived mediators a | 10667306 | [
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Investigation of a second 15S-lipoxygenase in humans and its expression in epithelial tissues. | nan | 10667314 | [
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Transcriptional and posttranscriptional regulation of 5-lipoxygenase mRNA expression in the human monocytic cell line Mono Mac 6 by transforming growth factor-beta and 1,25-dihydroxyvitamin D3. | nan | 10667317 | [
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Comparison of prostaglandin H synthase-1 and -2 structural stabilities. | nan | 10667318 | [
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Discovery of a new class of selective cyclooxygenase-2 (COX-2) inhibitor that covalently modifies the isozyme. | nan | 10667322 | [
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Mitigation of arthritis by high-dose administration of a COX-2 inhibitor in the collagen-induced arthritis model in the mouse. | nan | 10667323 | [
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Role of COX-2 inhibition on the formation and healing of gastric ulcers induced by indomethacin in the rat. | nan | 10667325 | [
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Role of type IIA secretory phospholipase A2 in arachidonic acid metabolism. | Recent recognition of the rapidly growing sPLA2 family has led to a suggestion that some of the previously described functions of sPLA2-IIA need to be reevaluated; since studies based upon enzyme activities and using inhibitors or antibodies against sPLA2-IIA may not discriminate these sPLA2s. Our present studies reconfirm the involvement of sPLA2-IIA in biological responses; demonstrated significant crosstalk between the two Ca(2+)-dependent PLA2s (cPLA2 and sPLA2) where one enzyme is required for the indu | 10667329 | [
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Role of type IIA secretory phospholipase A2 in arachidonic acid metabolism. | ction of the other; and revealed segregated coupling of discrete PLA2 and COX enzymes in the different phases of PG biosynthesis. Based upon the analysis of cells derived from sPLA2-IIA "natural knock-out" mice; it is apparent that sPLA2-IIA is not essential for the initiation of delayed PGE2 biosynthesis. However; it is capable of contributing to the delayed response as an enhancer when appropriately induced by proinflammatory stimuli; leading to optimal COX-2-dependent PGE2 generation. Importantly; in ord | 10667329 | [
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Role of type IIA secretory phospholipase A2 in arachidonic acid metabolism. | er for sPLA2-IIA (or related sPLA2 isozymes) to attack the biological membranes; so-called "membrane rearrangement" should take place in activated; but not resting; cells. Membrane rearrangement also occurs when cells are undergoing apoptosis; during which acidic phospholipids; the preferred substrates for sPLA2-IIA; are exposed on the outer leaflet of the plasma membranes. Nonetheless; in view of the dramatically elevated levels of sPLA2-IIA in inflamed or ischemic sites; it is likely that this extracellul | 10667329 | [
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Role of type IIA secretory phospholipase A2 in arachidonic acid metabolism. | ar isozyme participates in the expansion of chronic tissue disorders by augmenting generation of proinflammatory eicosanoids or lysophospholipids; depending upon the states of the inflammatory response. | 10667329 | [
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Phospholipase A2 is involved in chemotaxis of human leukocytes. | nan | 10667330 | [
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Suppression of acute experimental inflammation by antisense oligonucleotides targeting secretory phospholipase A2 (sPLA2) in vitro and in vivo experiments. | In HepG2 cells phosphorothioate modified antisense oligonucleotides against a sequence in the Ca2+ binding domain (AS-Ca2+) of type II sPLA2 mRNA restrained IL-6-induced synthesis of sPLA2 protein; sPLA2 mRNA (northern blot); and abolished IL-6 stimulated PGE2 release. An antisense oligonucleotide corresponding to a sequence in the catalytic domain (AS-Cat) of sPLA2 was less effective. The antisense oligonucleotides did not affect albumin synthesis in HepG2 cells; additionally demonstrating their specificit | 10667331 | [
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Suppression of acute experimental inflammation by antisense oligonucleotides targeting secretory phospholipase A2 (sPLA2) in vitro and in vivo experiments. | y. The corresponding AS-Ca2+ against a homologous part of the rat sPLA2 mRNA depressed rat carrageenin oedema for 60-70%. Identical suppression was achieved by specific low molecular weight inhibitors of sPLA2. Since cyclo- and 5-lipoxygenase inhibitors exerted similar reductions of carrageenin oedema type II sPLA2 dependent eicosanoid formation seems to be a key cascade in this type of inflammation. | 10667331 | [
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Comparison of recombinant types IIA, V and IIC phospholipase A2S, the three related mammalian secretory phospholipase A2 isozymes. | nan | 10667332 | [
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Respective roles of the 14 kDa and 85 kDa phospholipase A2 enzymes in human monocyte eicosanoid formation. | Human monocytes possess both the cytosolic 85 kDa phospholipase (PLA) A2 and a 14 kDa PLA2 and are capable of simultaneously producing prostanoids (PG); leukotrienes (LT) and platelet activating factor (PAF). As the exact roles of the two enzymes in monocyte lipid mediator formation was unclear; both selective PLA2 inhibitors and antisense were used to elucidate their respective roles. Reduction in 85 kDa PLA2 cellular protein levels by initiation site-directed antisense (SK 7111) or exposure to the 85 kDa | 10667333 | [
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Respective roles of the 14 kDa and 85 kDa phospholipase A2 enzymes in human monocyte eicosanoid formation. | PLA2 inhibitor; arachidonyl trifluormethyl ketone (AACOCF3); prevented A23187 or zymosan-stimulated monocytes prostanoid formation but not LTC4 or PAF production. This confirmed the important role of the 85 kDa PLA2 in prostanoid formation but indicated a less significant role in LT or PAF biosynthesis. Alternatively; treatment of monocytes with the selective; active-site-directed 14 kDa PLA2 inhibitor; SB 203347; totally inhibited LT and PAF formation; while prostanoid formation was not altered. Addition o | 10667333 | [
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Respective roles of the 14 kDa and 85 kDa phospholipase A2 enzymes in human monocyte eicosanoid formation. | f 20 uM exogenous arachidonic acid (AA) to monocytes exposed to SB 203347 did not alter A23187-induced LTC4 generation; indicating that SB 203347 had no effect on downstream AA metabolizing enzymes in this setting. Taken together; these results provide evidence that the 14 kDa PLA2 provides substrate for monocyte LT and PAF formation; while the 85 kDa PLA2 plays a more significant role in the formation of PG. | 10667333 | [
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Modulation of long-term potentiation in the CA1 area of rat hippocampus by platelet-activating factor. | nan | 10667334 | [
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PPARs: nuclear receptors for fatty acids, eicosanoids, and xenobiotics. | The peroxisome proliferator-activated receptors have enjoyed the spotlight for many reasons. These transcription factors are ligand-inducible nuclear receptors that modulate gene expression in response to a broad spectrum of compounds. The recognition that PPARs are indeed nuclear receptors for polyunsaturated fatty acids; some eicosanoids and also lipid-lowering and antidiabetic drugs; has opened many exciting avenues of research and drug discovery. Recent studies on the PPAR function have extended the rol | 10667335 | [
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PPARs: nuclear receptors for fatty acids, eicosanoids, and xenobiotics. | e of these transcription factors beyond energy homeostasis to master gene in adipogenesis and also determinants in inflammation control. While rapid advances have been made; it is clear that we are far from a global understanding of the mechanisms and functions of PPARs. | 10667335 | [
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Molecular cloning and characterization of leukotriene B4 receptor. | nan | 10667336 | [
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Determinants of receptor subtype specificity in the LPA-like lipid mediator family. | nan | 10667337 | [
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Subunits and cellular occurrence of the 12(S)-HETE binding complex. | nan | 10667338 | [
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A subfamily of G protein-coupled cellular receptors for lysophospholipids and lysosphingolipids. | The results of molecular cloning and homology searches have identified a minimum of five different proteins of the endothelial differentiation gene (edg) encoded subfamily of GPCRs. Edg protein GPCRs show amino acid sequence identity of 31% to 34% as a subfamily; but contain two homology clusters with greater similarity of structures and functions. One cluster of high amino acid sequence homology includes Edg-2 and Edg-4 proteins; that encode GPCRs for LPA; but not lysosphingolipids. A second homology clust | 10667339 | [
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