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<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"carbachol"/ induces disease /"Bradycardia"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Case report: acute unintentional /"carbachol"/ intoxication. - Abstract: INTRODUCTION: Intoxications with /"carbachol"/, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning. METHODS: The son of an 84-year-old male discovered a newspaper report stating clinical success with plant extracts in Alzheimer's disease. The mode of action was said to be comparable to that of the synthetic compound '/"carbamylcholin"/'; that is, /"carbachol"/. He bought 25 g of /"carbachol"/ as pure substance in a pharmacy, and the father was administered 400 to 500 mg. /"Carbachol"/ concentrations in serum and urine on day 1 and 2 of hospital admission were analysed by HPLC-mass spectrometry. RESULTS: Minutes after oral administration, the patient developed nausea, sweating and hypotension, and finally collapsed. /"Bradycardia"/, cholinergic symptoms and asystole occurred. Initial cardiopulmonary resuscitation and immediate treatment with adrenaline (epinephrine), atropine and furosemide was successful. On hospital admission, blood pressure of the intubated, bradyarrhythmic patient was 100/65 mmHg. Further signs were hyperhidrosis, hypersalivation, bronchorrhoea, and severe miosis; the electrocardiographic finding was atrio-ventricular dissociation. High doses of atropine (up to 50 mg per 24 hours), adrenaline and dopamine were necessary. The patient was extubated 1 week later. However, increased dyspnoea and bronchospasm necessitated reintubation. Respiratory insufficiency was further worsened by Proteus mirabilis infection and severe bronchoconstriction. One week later, the patient was again extubated and 3 days later was transferred to a peripheral ward. On the next day he died, probably as a result of heart failure. Serum samples from the first and second days contained 3.6 and 1.9 mg/l /"carbachol"/, respectively. The corresponding urine concentrations amounted to 374 and 554 mg/l. CONCLUSION: This case started with a media report in a popular newspaper, initiated by published, peer-reviewed research on herbals, and involved human failure in a case history, medical examination and clinical treatment. For the first time, an analytical method for the determination of /"carbachol"/ in plasma and urine has been developed. The analysed /"carbachol"/ concentration exceeded the supposed serum level resulting from a therapeutic dose by a factor of 130 to 260. Especially in old patients, intensivists should consider intoxications (with cholinergics) as a cause of acute cardiovascular failure. Question: Does chemical /"carbachol"/ induce disease /"Bradycardia"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"carbachol"/ induces disease /"asystole"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Case report: acute unintentional /"carbachol"/ intoxication. - Abstract: INTRODUCTION: Intoxications with /"carbachol"/, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning. METHODS: The son of an 84-year-old male discovered a newspaper report stating clinical success with plant extracts in Alzheimer's disease. The mode of action was said to be comparable to that of the synthetic compound '/"carbamylcholin"/'; that is, /"carbachol"/. He bought 25 g of /"carbachol"/ as pure substance in a pharmacy, and the father was administered 400 to 500 mg. /"Carbachol"/ concentrations in serum and urine on day 1 and 2 of hospital admission were analysed by HPLC-mass spectrometry. RESULTS: Minutes after oral administration, the patient developed nausea, sweating and hypotension, and finally collapsed. Bradycardia, cholinergic symptoms and /"asystole"/ occurred. Initial cardiopulmonary resuscitation and immediate treatment with adrenaline (epinephrine), atropine and furosemide was successful. On hospital admission, blood pressure of the intubated, bradyarrhythmic patient was 100/65 mmHg. Further signs were hyperhidrosis, hypersalivation, bronchorrhoea, and severe miosis; the electrocardiographic finding was atrio-ventricular dissociation. High doses of atropine (up to 50 mg per 24 hours), adrenaline and dopamine were necessary. The patient was extubated 1 week later. However, increased dyspnoea and bronchospasm necessitated reintubation. Respiratory insufficiency was further worsened by Proteus mirabilis infection and severe bronchoconstriction. One week later, the patient was again extubated and 3 days later was transferred to a peripheral ward. On the next day he died, probably as a result of heart failure. Serum samples from the first and second days contained 3.6 and 1.9 mg/l /"carbachol"/, respectively. The corresponding urine concentrations amounted to 374 and 554 mg/l. CONCLUSION: This case started with a media report in a popular newspaper, initiated by published, peer-reviewed research on herbals, and involved human failure in a case history, medical examination and clinical treatment. For the first time, an analytical method for the determination of /"carbachol"/ in plasma and urine has been developed. The analysed /"carbachol"/ concentration exceeded the supposed serum level resulting from a therapeutic dose by a factor of 130 to 260. Especially in old patients, intensivists should consider intoxications (with cholinergics) as a cause of acute cardiovascular failure. Question: Does chemical /"carbachol"/ induce disease /"asystole"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"carbachol"/ induces disease /"heart failure"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Case report: acute unintentional /"carbachol"/ intoxication. - Abstract: INTRODUCTION: Intoxications with /"carbachol"/, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning. METHODS: The son of an 84-year-old male discovered a newspaper report stating clinical success with plant extracts in Alzheimer's disease. The mode of action was said to be comparable to that of the synthetic compound '/"carbamylcholin"/'; that is, /"carbachol"/. He bought 25 g of /"carbachol"/ as pure substance in a pharmacy, and the father was administered 400 to 500 mg. /"Carbachol"/ concentrations in serum and urine on day 1 and 2 of hospital admission were analysed by HPLC-mass spectrometry. RESULTS: Minutes after oral administration, the patient developed nausea, sweating and hypotension, and finally collapsed. Bradycardia, cholinergic symptoms and asystole occurred. Initial cardiopulmonary resuscitation and immediate treatment with adrenaline (epinephrine), atropine and furosemide was successful. On hospital admission, blood pressure of the intubated, bradyarrhythmic patient was 100/65 mmHg. Further signs were hyperhidrosis, hypersalivation, bronchorrhoea, and severe miosis; the electrocardiographic finding was atrio-ventricular dissociation. High doses of atropine (up to 50 mg per 24 hours), adrenaline and dopamine were necessary. The patient was extubated 1 week later. However, increased dyspnoea and bronchospasm necessitated reintubation. Respiratory insufficiency was further worsened by Proteus mirabilis infection and severe bronchoconstriction. One week later, the patient was again extubated and 3 days later was transferred to a peripheral ward. On the next day he died, probably as a result of /"heart failure"/. Serum samples from the first and second days contained 3.6 and 1.9 mg/l /"carbachol"/, respectively. The corresponding urine concentrations amounted to 374 and 554 mg/l. CONCLUSION: This case started with a media report in a popular newspaper, initiated by published, peer-reviewed research on herbals, and involved human failure in a case history, medical examination and clinical treatment. For the first time, an analytical method for the determination of /"carbachol"/ in plasma and urine has been developed. The analysed /"carbachol"/ concentration exceeded the supposed serum level resulting from a therapeutic dose by a factor of 130 to 260. Especially in old patients, intensivists should consider intoxications (with cholinergics) as a cause of acute cardiovascular failure. Question: Does chemical /"carbachol"/ induce disease /"heart failure"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"carbachol"/ induces disease /"hypotension"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Case report: acute unintentional /"carbachol"/ intoxication. - Abstract: INTRODUCTION: Intoxications with /"carbachol"/, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning. METHODS: The son of an 84-year-old male discovered a newspaper report stating clinical success with plant extracts in Alzheimer's disease. The mode of action was said to be comparable to that of the synthetic compound '/"carbamylcholin"/'; that is, /"carbachol"/. He bought 25 g of /"carbachol"/ as pure substance in a pharmacy, and the father was administered 400 to 500 mg. /"Carbachol"/ concentrations in serum and urine on day 1 and 2 of hospital admission were analysed by HPLC-mass spectrometry. RESULTS: Minutes after oral administration, the patient developed nausea, sweating and /"hypotension"/, and finally collapsed. Bradycardia, cholinergic symptoms and asystole occurred. Initial cardiopulmonary resuscitation and immediate treatment with adrenaline (epinephrine), atropine and furosemide was successful. On hospital admission, blood pressure of the intubated, bradyarrhythmic patient was 100/65 mmHg. Further signs were hyperhidrosis, hypersalivation, bronchorrhoea, and severe miosis; the electrocardiographic finding was atrio-ventricular dissociation. High doses of atropine (up to 50 mg per 24 hours), adrenaline and dopamine were necessary. The patient was extubated 1 week later. However, increased dyspnoea and bronchospasm necessitated reintubation. Respiratory insufficiency was further worsened by Proteus mirabilis infection and severe bronchoconstriction. One week later, the patient was again extubated and 3 days later was transferred to a peripheral ward. On the next day he died, probably as a result of heart failure. Serum samples from the first and second days contained 3.6 and 1.9 mg/l /"carbachol"/, respectively. The corresponding urine concentrations amounted to 374 and 554 mg/l. CONCLUSION: This case started with a media report in a popular newspaper, initiated by published, peer-reviewed research on herbals, and involved human failure in a case history, medical examination and clinical treatment. For the first time, an analytical method for the determination of /"carbachol"/ in plasma and urine has been developed. The analysed /"carbachol"/ concentration exceeded the supposed serum level resulting from a therapeutic dose by a factor of 130 to 260. Especially in old patients, intensivists should consider intoxications (with cholinergics) as a cause of acute cardiovascular failure. Question: Does chemical /"carbachol"/ induce disease /"hypotension"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"carbachol"/ induces disease /"miosis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Case report: acute unintentional /"carbachol"/ intoxication. - Abstract: INTRODUCTION: Intoxications with /"carbachol"/, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning. METHODS: The son of an 84-year-old male discovered a newspaper report stating clinical success with plant extracts in Alzheimer's disease. The mode of action was said to be comparable to that of the synthetic compound '/"carbamylcholin"/'; that is, /"carbachol"/. He bought 25 g of /"carbachol"/ as pure substance in a pharmacy, and the father was administered 400 to 500 mg. /"Carbachol"/ concentrations in serum and urine on day 1 and 2 of hospital admission were analysed by HPLC-mass spectrometry. RESULTS: Minutes after oral administration, the patient developed nausea, sweating and hypotension, and finally collapsed. Bradycardia, cholinergic symptoms and asystole occurred. Initial cardiopulmonary resuscitation and immediate treatment with adrenaline (epinephrine), atropine and furosemide was successful. On hospital admission, blood pressure of the intubated, bradyarrhythmic patient was 100/65 mmHg. Further signs were hyperhidrosis, hypersalivation, bronchorrhoea, and severe /"miosis"/; the electrocardiographic finding was atrio-ventricular dissociation. High doses of atropine (up to 50 mg per 24 hours), adrenaline and dopamine were necessary. The patient was extubated 1 week later. However, increased dyspnoea and bronchospasm necessitated reintubation. Respiratory insufficiency was further worsened by Proteus mirabilis infection and severe bronchoconstriction. One week later, the patient was again extubated and 3 days later was transferred to a peripheral ward. On the next day he died, probably as a result of heart failure. Serum samples from the first and second days contained 3.6 and 1.9 mg/l /"carbachol"/, respectively. The corresponding urine concentrations amounted to 374 and 554 mg/l. CONCLUSION: This case started with a media report in a popular newspaper, initiated by published, peer-reviewed research on herbals, and involved human failure in a case history, medical examination and clinical treatment. For the first time, an analytical method for the determination of /"carbachol"/ in plasma and urine has been developed. The analysed /"carbachol"/ concentration exceeded the supposed serum level resulting from a therapeutic dose by a factor of 130 to 260. Especially in old patients, intensivists should consider intoxications (with cholinergics) as a cause of acute cardiovascular failure. Question: Does chemical /"carbachol"/ induce disease /"miosis"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"carbachol"/ induces disease /"hyperhidrosis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Case report: acute unintentional /"carbachol"/ intoxication. - Abstract: INTRODUCTION: Intoxications with /"carbachol"/, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning. METHODS: The son of an 84-year-old male discovered a newspaper report stating clinical success with plant extracts in Alzheimer's disease. The mode of action was said to be comparable to that of the synthetic compound '/"carbamylcholin"/'; that is, /"carbachol"/. He bought 25 g of /"carbachol"/ as pure substance in a pharmacy, and the father was administered 400 to 500 mg. /"Carbachol"/ concentrations in serum and urine on day 1 and 2 of hospital admission were analysed by HPLC-mass spectrometry. RESULTS: Minutes after oral administration, the patient developed nausea, sweating and hypotension, and finally collapsed. Bradycardia, cholinergic symptoms and asystole occurred. Initial cardiopulmonary resuscitation and immediate treatment with adrenaline (epinephrine), atropine and furosemide was successful. On hospital admission, blood pressure of the intubated, bradyarrhythmic patient was 100/65 mmHg. Further signs were /"hyperhidrosis"/, hypersalivation, bronchorrhoea, and severe miosis; the electrocardiographic finding was atrio-ventricular dissociation. High doses of atropine (up to 50 mg per 24 hours), adrenaline and dopamine were necessary. The patient was extubated 1 week later. However, increased dyspnoea and bronchospasm necessitated reintubation. Respiratory insufficiency was further worsened by Proteus mirabilis infection and severe bronchoconstriction. One week later, the patient was again extubated and 3 days later was transferred to a peripheral ward. On the next day he died, probably as a result of heart failure. Serum samples from the first and second days contained 3.6 and 1.9 mg/l /"carbachol"/, respectively. The corresponding urine concentrations amounted to 374 and 554 mg/l. CONCLUSION: This case started with a media report in a popular newspaper, initiated by published, peer-reviewed research on herbals, and involved human failure in a case history, medical examination and clinical treatment. For the first time, an analytical method for the determination of /"carbachol"/ in plasma and urine has been developed. The analysed /"carbachol"/ concentration exceeded the supposed serum level resulting from a therapeutic dose by a factor of 130 to 260. Especially in old patients, intensivists should consider intoxications (with cholinergics) as a cause of acute cardiovascular failure. Question: Does chemical /"carbachol"/ induce disease /"hyperhidrosis"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"carbachol"/ induces disease /"hypersalivation"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Case report: acute unintentional /"carbachol"/ intoxication. - Abstract: INTRODUCTION: Intoxications with /"carbachol"/, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning. METHODS: The son of an 84-year-old male discovered a newspaper report stating clinical success with plant extracts in Alzheimer's disease. The mode of action was said to be comparable to that of the synthetic compound '/"carbamylcholin"/'; that is, /"carbachol"/. He bought 25 g of /"carbachol"/ as pure substance in a pharmacy, and the father was administered 400 to 500 mg. /"Carbachol"/ concentrations in serum and urine on day 1 and 2 of hospital admission were analysed by HPLC-mass spectrometry. RESULTS: Minutes after oral administration, the patient developed nausea, sweating and hypotension, and finally collapsed. Bradycardia, cholinergic symptoms and asystole occurred. Initial cardiopulmonary resuscitation and immediate treatment with adrenaline (epinephrine), atropine and furosemide was successful. On hospital admission, blood pressure of the intubated, bradyarrhythmic patient was 100/65 mmHg. Further signs were hyperhidrosis, /"hypersalivation"/, bronchorrhoea, and severe miosis; the electrocardiographic finding was atrio-ventricular dissociation. High doses of atropine (up to 50 mg per 24 hours), adrenaline and dopamine were necessary. The patient was extubated 1 week later. However, increased dyspnoea and bronchospasm necessitated reintubation. Respiratory insufficiency was further worsened by Proteus mirabilis infection and severe bronchoconstriction. One week later, the patient was again extubated and 3 days later was transferred to a peripheral ward. On the next day he died, probably as a result of heart failure. Serum samples from the first and second days contained 3.6 and 1.9 mg/l /"carbachol"/, respectively. The corresponding urine concentrations amounted to 374 and 554 mg/l. CONCLUSION: This case started with a media report in a popular newspaper, initiated by published, peer-reviewed research on herbals, and involved human failure in a case history, medical examination and clinical treatment. For the first time, an analytical method for the determination of /"carbachol"/ in plasma and urine has been developed. The analysed /"carbachol"/ concentration exceeded the supposed serum level resulting from a therapeutic dose by a factor of 130 to 260. Especially in old patients, intensivists should consider intoxications (with cholinergics) as a cause of acute cardiovascular failure. Question: Does chemical /"carbachol"/ induce disease /"hypersalivation"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"carbachol"/ induces disease /"acute cardiovascular failure"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Case report: acute unintentional /"carbachol"/ intoxication. - Abstract: INTRODUCTION: Intoxications with /"carbachol"/, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning. METHODS: The son of an 84-year-old male discovered a newspaper report stating clinical success with plant extracts in Alzheimer's disease. The mode of action was said to be comparable to that of the synthetic compound '/"carbamylcholin"/'; that is, /"carbachol"/. He bought 25 g of /"carbachol"/ as pure substance in a pharmacy, and the father was administered 400 to 500 mg. /"Carbachol"/ concentrations in serum and urine on day 1 and 2 of hospital admission were analysed by HPLC-mass spectrometry. RESULTS: Minutes after oral administration, the patient developed nausea, sweating and hypotension, and finally collapsed. Bradycardia, cholinergic symptoms and asystole occurred. Initial cardiopulmonary resuscitation and immediate treatment with adrenaline (epinephrine), atropine and furosemide was successful. On hospital admission, blood pressure of the intubated, bradyarrhythmic patient was 100/65 mmHg. Further signs were hyperhidrosis, hypersalivation, bronchorrhoea, and severe miosis; the electrocardiographic finding was atrio-ventricular dissociation. High doses of atropine (up to 50 mg per 24 hours), adrenaline and dopamine were necessary. The patient was extubated 1 week later. However, increased dyspnoea and bronchospasm necessitated reintubation. Respiratory insufficiency was further worsened by Proteus mirabilis infection and severe bronchoconstriction. One week later, the patient was again extubated and 3 days later was transferred to a peripheral ward. On the next day he died, probably as a result of heart failure. Serum samples from the first and second days contained 3.6 and 1.9 mg/l /"carbachol"/, respectively. The corresponding urine concentrations amounted to 374 and 554 mg/l. CONCLUSION: This case started with a media report in a popular newspaper, initiated by published, peer-reviewed research on herbals, and involved human failure in a case history, medical examination and clinical treatment. For the first time, an analytical method for the determination of /"carbachol"/ in plasma and urine has been developed. The analysed /"carbachol"/ concentration exceeded the supposed serum level resulting from a therapeutic dose by a factor of 130 to 260. Especially in old patients, intensivists should consider intoxications (with cholinergics) as a cause of /"acute cardiovascular failure"/. Question: Does chemical /"carbachol"/ induce disease /"acute cardiovascular failure"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"adrenaline"/ induces disease /"heart failure"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Case report: acute unintentional carbachol intoxication. - Abstract: INTRODUCTION: Intoxications with carbachol, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning. METHODS: The son of an 84-year-old male discovered a newspaper report stating clinical success with plant extracts in Alzheimer's disease. The mode of action was said to be comparable to that of the synthetic compound 'carbamylcholin'; that is, carbachol. He bought 25 g of carbachol as pure substance in a pharmacy, and the father was administered 400 to 500 mg. Carbachol concentrations in serum and urine on day 1 and 2 of hospital admission were analysed by HPLC-mass spectrometry. RESULTS: Minutes after oral administration, the patient developed nausea, sweating and hypotension, and finally collapsed. Bradycardia, cholinergic symptoms and asystole occurred. Initial cardiopulmonary resuscitation and immediate treatment with /"adrenaline"/ (/"epinephrine"/), atropine and furosemide was successful. On hospital admission, blood pressure of the intubated, bradyarrhythmic patient was 100/65 mmHg. Further signs were hyperhidrosis, hypersalivation, bronchorrhoea, and severe miosis; the electrocardiographic finding was atrio-ventricular dissociation. High doses of atropine (up to 50 mg per 24 hours), /"adrenaline"/ and dopamine were necessary. The patient was extubated 1 week later. However, increased dyspnoea and bronchospasm necessitated reintubation. Respiratory insufficiency was further worsened by Proteus mirabilis infection and severe bronchoconstriction. One week later, the patient was again extubated and 3 days later was transferred to a peripheral ward. On the next day he died, probably as a result of /"heart failure"/. Serum samples from the first and second days contained 3.6 and 1.9 mg/l carbachol, respectively. The corresponding urine concentrations amounted to 374 and 554 mg/l. CONCLUSION: This case started with a media report in a popular newspaper, initiated by published, peer-reviewed research on herbals, and involved human failure in a case history, medical examination and clinical treatment. For the first time, an analytical method for the determination of carbachol in plasma and urine has been developed. The analysed carbachol concentration exceeded the supposed serum level resulting from a therapeutic dose by a factor of 130 to 260. Especially in old patients, intensivists should consider intoxications (with cholinergics) as a cause of acute cardiovascular failure. Question: Does chemical /"adrenaline"/ induce disease /"heart failure"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"furosemide"/ induces disease /"atrio-ventricular dissociation"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Case report: acute unintentional carbachol intoxication. - Abstract: INTRODUCTION: Intoxications with carbachol, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning. METHODS: The son of an 84-year-old male discovered a newspaper report stating clinical success with plant extracts in Alzheimer's disease. The mode of action was said to be comparable to that of the synthetic compound 'carbamylcholin'; that is, carbachol. He bought 25 g of carbachol as pure substance in a pharmacy, and the father was administered 400 to 500 mg. Carbachol concentrations in serum and urine on day 1 and 2 of hospital admission were analysed by HPLC-mass spectrometry. RESULTS: Minutes after oral administration, the patient developed nausea, sweating and hypotension, and finally collapsed. Bradycardia, cholinergic symptoms and asystole occurred. Initial cardiopulmonary resuscitation and immediate treatment with adrenaline (epinephrine), atropine and /"furosemide"/ was successful. On hospital admission, blood pressure of the intubated, bradyarrhythmic patient was 100/65 mmHg. Further signs were hyperhidrosis, hypersalivation, bronchorrhoea, and severe miosis; the electrocardiographic finding was /"atrio-ventricular dissociation"/. High doses of atropine (up to 50 mg per 24 hours), adrenaline and dopamine were necessary. The patient was extubated 1 week later. However, increased dyspnoea and bronchospasm necessitated reintubation. Respiratory insufficiency was further worsened by Proteus mirabilis infection and severe bronchoconstriction. One week later, the patient was again extubated and 3 days later was transferred to a peripheral ward. On the next day he died, probably as a result of heart failure. Serum samples from the first and second days contained 3.6 and 1.9 mg/l carbachol, respectively. The corresponding urine concentrations amounted to 374 and 554 mg/l. CONCLUSION: This case started with a media report in a popular newspaper, initiated by published, peer-reviewed research on herbals, and involved human failure in a case history, medical examination and clinical treatment. For the first time, an analytical method for the determination of carbachol in plasma and urine has been developed. The analysed carbachol concentration exceeded the supposed serum level resulting from a therapeutic dose by a factor of 130 to 260. Especially in old patients, intensivists should consider intoxications (with cholinergics) as a cause of acute cardiovascular failure. Question: Does chemical /"furosemide"/ induce disease /"atrio-ventricular dissociation"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"dopamine"/ induces disease /"Respiratory insufficiency"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Case report: acute unintentional carbachol intoxication. - Abstract: INTRODUCTION: Intoxications with carbachol, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning. METHODS: The son of an 84-year-old male discovered a newspaper report stating clinical success with plant extracts in Alzheimer's disease. The mode of action was said to be comparable to that of the synthetic compound 'carbamylcholin'; that is, carbachol. He bought 25 g of carbachol as pure substance in a pharmacy, and the father was administered 400 to 500 mg. Carbachol concentrations in serum and urine on day 1 and 2 of hospital admission were analysed by HPLC-mass spectrometry. RESULTS: Minutes after oral administration, the patient developed nausea, sweating and hypotension, and finally collapsed. Bradycardia, cholinergic symptoms and asystole occurred. Initial cardiopulmonary resuscitation and immediate treatment with adrenaline (epinephrine), atropine and furosemide was successful. On hospital admission, blood pressure of the intubated, bradyarrhythmic patient was 100/65 mmHg. Further signs were hyperhidrosis, hypersalivation, bronchorrhoea, and severe miosis; the electrocardiographic finding was atrio-ventricular dissociation. High doses of atropine (up to 50 mg per 24 hours), adrenaline and /"dopamine"/ were necessary. The patient was extubated 1 week later. However, increased dyspnoea and bronchospasm necessitated reintubation. /"Respiratory insufficiency"/ was further worsened by Proteus mirabilis infection and severe bronchoconstriction. One week later, the patient was again extubated and 3 days later was transferred to a peripheral ward. On the next day he died, probably as a result of heart failure. Serum samples from the first and second days contained 3.6 and 1.9 mg/l carbachol, respectively. The corresponding urine concentrations amounted to 374 and 554 mg/l. CONCLUSION: This case started with a media report in a popular newspaper, initiated by published, peer-reviewed research on herbals, and involved human failure in a case history, medical examination and clinical treatment. For the first time, an analytical method for the determination of carbachol in plasma and urine has been developed. The analysed carbachol concentration exceeded the supposed serum level resulting from a therapeutic dose by a factor of 130 to 260. Especially in old patients, intensivists should consider intoxications (with cholinergics) as a cause of acute cardiovascular failure. Question: Does chemical /"dopamine"/ induce disease /"Respiratory insufficiency"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"carbachol"/ induces disease /"Respiratory insufficiency"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Case report: acute unintentional /"carbachol"/ intoxication. - Abstract: INTRODUCTION: Intoxications with /"carbachol"/, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning. METHODS: The son of an 84-year-old male discovered a newspaper report stating clinical success with plant extracts in Alzheimer's disease. The mode of action was said to be comparable to that of the synthetic compound '/"carbamylcholin"/'; that is, /"carbachol"/. He bought 25 g of /"carbachol"/ as pure substance in a pharmacy, and the father was administered 400 to 500 mg. /"Carbachol"/ concentrations in serum and urine on day 1 and 2 of hospital admission were analysed by HPLC-mass spectrometry. RESULTS: Minutes after oral administration, the patient developed nausea, sweating and hypotension, and finally collapsed. Bradycardia, cholinergic symptoms and asystole occurred. Initial cardiopulmonary resuscitation and immediate treatment with adrenaline (epinephrine), atropine and furosemide was successful. On hospital admission, blood pressure of the intubated, bradyarrhythmic patient was 100/65 mmHg. Further signs were hyperhidrosis, hypersalivation, bronchorrhoea, and severe miosis; the electrocardiographic finding was atrio-ventricular dissociation. High doses of atropine (up to 50 mg per 24 hours), adrenaline and dopamine were necessary. The patient was extubated 1 week later. However, increased dyspnoea and bronchospasm necessitated reintubation. /"Respiratory insufficiency"/ was further worsened by Proteus mirabilis infection and severe bronchoconstriction. One week later, the patient was again extubated and 3 days later was transferred to a peripheral ward. On the next day he died, probably as a result of heart failure. Serum samples from the first and second days contained 3.6 and 1.9 mg/l /"carbachol"/, respectively. The corresponding urine concentrations amounted to 374 and 554 mg/l. CONCLUSION: This case started with a media report in a popular newspaper, initiated by published, peer-reviewed research on herbals, and involved human failure in a case history, medical examination and clinical treatment. For the first time, an analytical method for the determination of /"carbachol"/ in plasma and urine has been developed. The analysed /"carbachol"/ concentration exceeded the supposed serum level resulting from a therapeutic dose by a factor of 130 to 260. Especially in old patients, intensivists should consider intoxications (with cholinergics) as a cause of acute cardiovascular failure. Question: Does chemical /"carbachol"/ induce disease /"Respiratory insufficiency"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"atropine"/ induces disease /"asystole"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Case report: acute unintentional carbachol intoxication. - Abstract: INTRODUCTION: Intoxications with carbachol, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning. METHODS: The son of an 84-year-old male discovered a newspaper report stating clinical success with plant extracts in Alzheimer's disease. The mode of action was said to be comparable to that of the synthetic compound 'carbamylcholin'; that is, carbachol. He bought 25 g of carbachol as pure substance in a pharmacy, and the father was administered 400 to 500 mg. Carbachol concentrations in serum and urine on day 1 and 2 of hospital admission were analysed by HPLC-mass spectrometry. RESULTS: Minutes after oral administration, the patient developed nausea, sweating and hypotension, and finally collapsed. Bradycardia, cholinergic symptoms and /"asystole"/ occurred. Initial cardiopulmonary resuscitation and immediate treatment with adrenaline (epinephrine), /"atropine"/ and furosemide was successful. On hospital admission, blood pressure of the intubated, bradyarrhythmic patient was 100/65 mmHg. Further signs were hyperhidrosis, hypersalivation, bronchorrhoea, and severe miosis; the electrocardiographic finding was atrio-ventricular dissociation. High doses of /"atropine"/ (up to 50 mg per 24 hours), adrenaline and dopamine were necessary. The patient was extubated 1 week later. However, increased dyspnoea and bronchospasm necessitated reintubation. Respiratory insufficiency was further worsened by Proteus mirabilis infection and severe bronchoconstriction. One week later, the patient was again extubated and 3 days later was transferred to a peripheral ward. On the next day he died, probably as a result of heart failure. Serum samples from the first and second days contained 3.6 and 1.9 mg/l carbachol, respectively. The corresponding urine concentrations amounted to 374 and 554 mg/l. CONCLUSION: This case started with a media report in a popular newspaper, initiated by published, peer-reviewed research on herbals, and involved human failure in a case history, medical examination and clinical treatment. For the first time, an analytical method for the determination of carbachol in plasma and urine has been developed. The analysed carbachol concentration exceeded the supposed serum level resulting from a therapeutic dose by a factor of 130 to 260. Especially in old patients, intensivists should consider intoxications (with cholinergics) as a cause of acute cardiovascular failure. Question: Does chemical /"atropine"/ induce disease /"asystole"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"atropine"/ induces disease /"nausea"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Case report: acute unintentional carbachol intoxication. - Abstract: INTRODUCTION: Intoxications with carbachol, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning. METHODS: The son of an 84-year-old male discovered a newspaper report stating clinical success with plant extracts in Alzheimer's disease. The mode of action was said to be comparable to that of the synthetic compound 'carbamylcholin'; that is, carbachol. He bought 25 g of carbachol as pure substance in a pharmacy, and the father was administered 400 to 500 mg. Carbachol concentrations in serum and urine on day 1 and 2 of hospital admission were analysed by HPLC-mass spectrometry. RESULTS: Minutes after oral administration, the patient developed /"nausea"/, sweating and hypotension, and finally collapsed. Bradycardia, cholinergic symptoms and asystole occurred. Initial cardiopulmonary resuscitation and immediate treatment with adrenaline (epinephrine), /"atropine"/ and furosemide was successful. On hospital admission, blood pressure of the intubated, bradyarrhythmic patient was 100/65 mmHg. Further signs were hyperhidrosis, hypersalivation, bronchorrhoea, and severe miosis; the electrocardiographic finding was atrio-ventricular dissociation. High doses of /"atropine"/ (up to 50 mg per 24 hours), adrenaline and dopamine were necessary. The patient was extubated 1 week later. However, increased dyspnoea and bronchospasm necessitated reintubation. Respiratory insufficiency was further worsened by Proteus mirabilis infection and severe bronchoconstriction. One week later, the patient was again extubated and 3 days later was transferred to a peripheral ward. On the next day he died, probably as a result of heart failure. Serum samples from the first and second days contained 3.6 and 1.9 mg/l carbachol, respectively. The corresponding urine concentrations amounted to 374 and 554 mg/l. CONCLUSION: This case started with a media report in a popular newspaper, initiated by published, peer-reviewed research on herbals, and involved human failure in a case history, medical examination and clinical treatment. For the first time, an analytical method for the determination of carbachol in plasma and urine has been developed. The analysed carbachol concentration exceeded the supposed serum level resulting from a therapeutic dose by a factor of 130 to 260. Especially in old patients, intensivists should consider intoxications (with cholinergics) as a cause of acute cardiovascular failure. Question: Does chemical /"atropine"/ induce disease /"nausea"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"dopamine"/ induces disease /"nausea"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Case report: acute unintentional carbachol intoxication. - Abstract: INTRODUCTION: Intoxications with carbachol, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning. METHODS: The son of an 84-year-old male discovered a newspaper report stating clinical success with plant extracts in Alzheimer's disease. The mode of action was said to be comparable to that of the synthetic compound 'carbamylcholin'; that is, carbachol. He bought 25 g of carbachol as pure substance in a pharmacy, and the father was administered 400 to 500 mg. Carbachol concentrations in serum and urine on day 1 and 2 of hospital admission were analysed by HPLC-mass spectrometry. RESULTS: Minutes after oral administration, the patient developed /"nausea"/, sweating and hypotension, and finally collapsed. Bradycardia, cholinergic symptoms and asystole occurred. Initial cardiopulmonary resuscitation and immediate treatment with adrenaline (epinephrine), atropine and furosemide was successful. On hospital admission, blood pressure of the intubated, bradyarrhythmic patient was 100/65 mmHg. Further signs were hyperhidrosis, hypersalivation, bronchorrhoea, and severe miosis; the electrocardiographic finding was atrio-ventricular dissociation. High doses of atropine (up to 50 mg per 24 hours), adrenaline and /"dopamine"/ were necessary. The patient was extubated 1 week later. However, increased dyspnoea and bronchospasm necessitated reintubation. Respiratory insufficiency was further worsened by Proteus mirabilis infection and severe bronchoconstriction. One week later, the patient was again extubated and 3 days later was transferred to a peripheral ward. On the next day he died, probably as a result of heart failure. Serum samples from the first and second days contained 3.6 and 1.9 mg/l carbachol, respectively. The corresponding urine concentrations amounted to 374 and 554 mg/l. CONCLUSION: This case started with a media report in a popular newspaper, initiated by published, peer-reviewed research on herbals, and involved human failure in a case history, medical examination and clinical treatment. For the first time, an analytical method for the determination of carbachol in plasma and urine has been developed. The analysed carbachol concentration exceeded the supposed serum level resulting from a therapeutic dose by a factor of 130 to 260. Especially in old patients, intensivists should consider intoxications (with cholinergics) as a cause of acute cardiovascular failure. Question: Does chemical /"dopamine"/ induce disease /"nausea"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"rizatriptan"/ induces disease /"nausea"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Crossover comparison of efficacy and preference for /"rizatriptan"/ 10 mg versus ergotamine/caffeine in migraine. - Abstract: /"Rizatriptan"/ is a selective 5-HT(1B/1D) receptor agonist with rapid oral absorption and early onset of action in the acute treatment of migraine. This randomized double- blind crossover outpatient study assessed the preference for 1 /"rizatriptan"/ 10 mg tablet to 2 ergotamine 1 mg/caffeine 100 mg tablets in 439 patients treating a single migraine attack with each therapy. Of patients expressing a preference (89.1%), more than twice as many preferred /"rizatriptan"/ to ergotamine/caffeine (69.9 vs. 30.1%, p < or = 0.001). Faster relief of headache was the most important reason for preference, cited by 67.3% of patients preferring /"rizatriptan"/ and 54.2% of patients who preferred ergotamine/caffeine. The co-primary endpoint of being pain free at 2 h was also in favor of /"rizatriptan"/. Forty-nine percent of patients were pain free 2 h after /"rizatriptan"/, compared with 24.3% treated with ergotamine/caffeine (p < or = 0.001), /"rizatriptan"/ being superior within 1 h of treatment. Headache relief at 2 h was 75.9% for /"rizatriptan"/ and 47.3% for ergotamine/caffeine (p < or = 0.001), with /"rizatriptan"/ being superior to ergotamine/caffeine within 30 min of dosing. Almost 36% of patients taking /"rizatriptan"/ were pain free at 2 h and had no recurrence or need for additional medication within 24 h, compared to 20% of patients on ergotamine/caffeine (p < or = 0.001). /"Rizatriptan"/ was also superior to ergotamine/caffeine in the proportions of patients with no /"nausea"/, vomiting, phonophobia or photophobia and for patients with normal function 2 h after drug intake (p < or = 0.001). More patients were (completely, very or somewhat) satisfied 2 h after treatment with /"rizatriptan"/ (69.8%) than at 2 h after treatment with ergotamine/caffeine (38.6%, p < or = 0.001). Recurrence rates were 31.4% with /"rizatriptan"/ and 15.3% with ergotamine/caffeine. Both active treatments were well tolerated. The most common adverse events (incidence > or = 5% in one group) after /"rizatriptan"/ and ergotamine/caffeine, respectively, were dizziness (6.7 and 5.3%), /"nausea"/ (4.2 and 8.5%) and somnolence (5.5 and 2.3%). Question: Does chemical /"rizatriptan"/ induce disease /"nausea"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"rizatriptan"/ induces disease /"dizziness"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Crossover comparison of efficacy and preference for /"rizatriptan"/ 10 mg versus ergotamine/caffeine in migraine. - Abstract: /"Rizatriptan"/ is a selective 5-HT(1B/1D) receptor agonist with rapid oral absorption and early onset of action in the acute treatment of migraine. This randomized double- blind crossover outpatient study assessed the preference for 1 /"rizatriptan"/ 10 mg tablet to 2 ergotamine 1 mg/caffeine 100 mg tablets in 439 patients treating a single migraine attack with each therapy. Of patients expressing a preference (89.1%), more than twice as many preferred /"rizatriptan"/ to ergotamine/caffeine (69.9 vs. 30.1%, p < or = 0.001). Faster relief of headache was the most important reason for preference, cited by 67.3% of patients preferring /"rizatriptan"/ and 54.2% of patients who preferred ergotamine/caffeine. The co-primary endpoint of being pain free at 2 h was also in favor of /"rizatriptan"/. Forty-nine percent of patients were pain free 2 h after /"rizatriptan"/, compared with 24.3% treated with ergotamine/caffeine (p < or = 0.001), /"rizatriptan"/ being superior within 1 h of treatment. Headache relief at 2 h was 75.9% for /"rizatriptan"/ and 47.3% for ergotamine/caffeine (p < or = 0.001), with /"rizatriptan"/ being superior to ergotamine/caffeine within 30 min of dosing. Almost 36% of patients taking /"rizatriptan"/ were pain free at 2 h and had no recurrence or need for additional medication within 24 h, compared to 20% of patients on ergotamine/caffeine (p < or = 0.001). /"Rizatriptan"/ was also superior to ergotamine/caffeine in the proportions of patients with no nausea, vomiting, phonophobia or photophobia and for patients with normal function 2 h after drug intake (p < or = 0.001). More patients were (completely, very or somewhat) satisfied 2 h after treatment with /"rizatriptan"/ (69.8%) than at 2 h after treatment with ergotamine/caffeine (38.6%, p < or = 0.001). Recurrence rates were 31.4% with /"rizatriptan"/ and 15.3% with ergotamine/caffeine. Both active treatments were well tolerated. The most common adverse events (incidence > or = 5% in one group) after /"rizatriptan"/ and ergotamine/caffeine, respectively, were /"dizziness"/ (6.7 and 5.3%), nausea (4.2 and 8.5%) and somnolence (5.5 and 2.3%). Question: Does chemical /"rizatriptan"/ induce disease /"dizziness"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"caffeine"/ induces disease /"pain"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Crossover comparison of efficacy and preference for rizatriptan 10 mg versus ergotamine//"caffeine"/ in migraine. - Abstract: Rizatriptan is a selective 5-HT(1B/1D) receptor agonist with rapid oral absorption and early onset of action in the acute treatment of migraine. This randomized double- blind crossover outpatient study assessed the preference for 1 rizatriptan 10 mg tablet to 2 ergotamine 1 mg//"caffeine"/ 100 mg tablets in 439 patients treating a single migraine attack with each therapy. Of patients expressing a preference (89.1%), more than twice as many preferred rizatriptan to ergotamine//"caffeine"/ (69.9 vs. 30.1%, p < or = 0.001). Faster relief of headache was the most important reason for preference, cited by 67.3% of patients preferring rizatriptan and 54.2% of patients who preferred ergotamine//"caffeine"/. The co-primary endpoint of being /"pain"/ free at 2 h was also in favor of rizatriptan. Forty-nine percent of patients were /"pain"/ free 2 h after rizatriptan, compared with 24.3% treated with ergotamine//"caffeine"/ (p < or = 0.001), rizatriptan being superior within 1 h of treatment. Headache relief at 2 h was 75.9% for rizatriptan and 47.3% for ergotamine//"caffeine"/ (p < or = 0.001), with rizatriptan being superior to ergotamine//"caffeine"/ within 30 min of dosing. Almost 36% of patients taking rizatriptan were /"pain"/ free at 2 h and had no recurrence or need for additional medication within 24 h, compared to 20% of patients on ergotamine//"caffeine"/ (p < or = 0.001). Rizatriptan was also superior to ergotamine//"caffeine"/ in the proportions of patients with no nausea, vomiting, phonophobia or photophobia and for patients with normal function 2 h after drug intake (p < or = 0.001). More patients were (completely, very or somewhat) satisfied 2 h after treatment with rizatriptan (69.8%) than at 2 h after treatment with ergotamine//"caffeine"/ (38.6%, p < or = 0.001). Recurrence rates were 31.4% with rizatriptan and 15.3% with ergotamine//"caffeine"/. Both active treatments were well tolerated. The most common adverse events (incidence > or = 5% in one group) after rizatriptan and ergotamine//"caffeine"/, respectively, were dizziness (6.7 and 5.3%), nausea (4.2 and 8.5%) and somnolence (5.5 and 2.3%). Question: Does chemical /"caffeine"/ induce disease /"pain"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"caffeine"/ induces disease /"headache"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Crossover comparison of efficacy and preference for rizatriptan 10 mg versus ergotamine//"caffeine"/ in migraine. - Abstract: Rizatriptan is a selective 5-HT(1B/1D) receptor agonist with rapid oral absorption and early onset of action in the acute treatment of migraine. This randomized double- blind crossover outpatient study assessed the preference for 1 rizatriptan 10 mg tablet to 2 ergotamine 1 mg//"caffeine"/ 100 mg tablets in 439 patients treating a single migraine attack with each therapy. Of patients expressing a preference (89.1%), more than twice as many preferred rizatriptan to ergotamine//"caffeine"/ (69.9 vs. 30.1%, p < or = 0.001). Faster relief of /"headache"/ was the most important reason for preference, cited by 67.3% of patients preferring rizatriptan and 54.2% of patients who preferred ergotamine//"caffeine"/. The co-primary endpoint of being pain free at 2 h was also in favor of rizatriptan. Forty-nine percent of patients were pain free 2 h after rizatriptan, compared with 24.3% treated with ergotamine//"caffeine"/ (p < or = 0.001), rizatriptan being superior within 1 h of treatment. /"Headache"/ relief at 2 h was 75.9% for rizatriptan and 47.3% for ergotamine//"caffeine"/ (p < or = 0.001), with rizatriptan being superior to ergotamine//"caffeine"/ within 30 min of dosing. Almost 36% of patients taking rizatriptan were pain free at 2 h and had no recurrence or need for additional medication within 24 h, compared to 20% of patients on ergotamine//"caffeine"/ (p < or = 0.001). Rizatriptan was also superior to ergotamine//"caffeine"/ in the proportions of patients with no nausea, vomiting, phonophobia or photophobia and for patients with normal function 2 h after drug intake (p < or = 0.001). More patients were (completely, very or somewhat) satisfied 2 h after treatment with rizatriptan (69.8%) than at 2 h after treatment with ergotamine//"caffeine"/ (38.6%, p < or = 0.001). Recurrence rates were 31.4% with rizatriptan and 15.3% with ergotamine//"caffeine"/. Both active treatments were well tolerated. The most common adverse events (incidence > or = 5% in one group) after rizatriptan and ergotamine//"caffeine"/, respectively, were dizziness (6.7 and 5.3%), nausea (4.2 and 8.5%) and somnolence (5.5 and 2.3%). Question: Does chemical /"caffeine"/ induce disease /"headache"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"bleomycin"/ induces disease /"thrombotic thrombocytopenic purpura"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. - Abstract: Five patients with carcinoma developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with cisplatin, /"bleomycin"/, and a vinca alkaloid. One patient had /"thrombotic thrombocytopenic purpura"/, three the hemolytic-uremic syndrome, and one an apparent forme fruste of one of these disorders. Histologic examination of the renal tissue showed evidence of intravascular coagulation, primarily affecting the small arteries, arterioles, and glomeruli. Because each patient was tumor-free or had only a small tumor at the onset of this syndrome, the thrombotic microangiopathy may have been induced by chemotherapy. Diagnosis of this potentially fatal complication may be delayed or missed if renal tissue or the peripheral blood smear is not examined, because renal failure may be ascribed to cisplatin nephrotoxicity and the anemia and thrombocytopenia to drug-induced bone marrow suppression. Question: Does chemical /"bleomycin"/ induce disease /"thrombotic thrombocytopenic purpura"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"vinca alkaloid"/ induces disease /"hemolytic-uremic syndrome"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. - Abstract: Five patients with carcinoma developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with cisplatin, bleomycin, and a /"vinca alkaloid"/. One patient had thrombotic thrombocytopenic purpura, three the /"hemolytic-uremic syndrome"/, and one an apparent forme fruste of one of these disorders. Histologic examination of the renal tissue showed evidence of intravascular coagulation, primarily affecting the small arteries, arterioles, and glomeruli. Because each patient was tumor-free or had only a small tumor at the onset of this syndrome, the thrombotic microangiopathy may have been induced by chemotherapy. Diagnosis of this potentially fatal complication may be delayed or missed if renal tissue or the peripheral blood smear is not examined, because renal failure may be ascribed to cisplatin nephrotoxicity and the anemia and thrombocytopenia to drug-induced bone marrow suppression. Question: Does chemical /"vinca alkaloid"/ induce disease /"hemolytic-uremic syndrome"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"cisplatin"/ induces disease /"nephrotoxicity"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. - Abstract: Five patients with carcinoma developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with /"cisplatin"/, bleomycin, and a vinca alkaloid. One patient had thrombotic thrombocytopenic purpura, three the hemolytic-uremic syndrome, and one an apparent forme fruste of one of these disorders. Histologic examination of the renal tissue showed evidence of intravascular coagulation, primarily affecting the small arteries, arterioles, and glomeruli. Because each patient was tumor-free or had only a small tumor at the onset of this syndrome, the thrombotic microangiopathy may have been induced by chemotherapy. Diagnosis of this potentially fatal complication may be delayed or missed if renal tissue or the peripheral blood smear is not examined, because renal failure may be ascribed to /"cisplatin"/ /"nephrotoxicity"/ and the anemia and thrombocytopenia to drug-induced bone marrow suppression. Question: Does chemical /"cisplatin"/ induce disease /"nephrotoxicity"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"vinca alkaloid"/ induces disease /"nephrotoxicity"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. - Abstract: Five patients with carcinoma developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with cisplatin, bleomycin, and a /"vinca alkaloid"/. One patient had thrombotic thrombocytopenic purpura, three the hemolytic-uremic syndrome, and one an apparent forme fruste of one of these disorders. Histologic examination of the renal tissue showed evidence of intravascular coagulation, primarily affecting the small arteries, arterioles, and glomeruli. Because each patient was tumor-free or had only a small tumor at the onset of this syndrome, the thrombotic microangiopathy may have been induced by chemotherapy. Diagnosis of this potentially fatal complication may be delayed or missed if renal tissue or the peripheral blood smear is not examined, because renal failure may be ascribed to cisplatin /"nephrotoxicity"/ and the anemia and thrombocytopenia to drug-induced bone marrow suppression. Question: Does chemical /"vinca alkaloid"/ induce disease /"nephrotoxicity"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"cisplatin"/ induces disease /"thrombotic thrombocytopenic purpura"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. - Abstract: Five patients with carcinoma developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with /"cisplatin"/, bleomycin, and a vinca alkaloid. One patient had /"thrombotic thrombocytopenic purpura"/, three the hemolytic-uremic syndrome, and one an apparent forme fruste of one of these disorders. Histologic examination of the renal tissue showed evidence of intravascular coagulation, primarily affecting the small arteries, arterioles, and glomeruli. Because each patient was tumor-free or had only a small tumor at the onset of this syndrome, the thrombotic microangiopathy may have been induced by chemotherapy. Diagnosis of this potentially fatal complication may be delayed or missed if renal tissue or the peripheral blood smear is not examined, because renal failure may be ascribed to /"cisplatin"/ nephrotoxicity and the anemia and thrombocytopenia to drug-induced bone marrow suppression. Question: Does chemical /"cisplatin"/ induce disease /"thrombotic thrombocytopenic purpura"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"bleomycin"/ induces disease /"hemolytic-uremic syndrome"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. - Abstract: Five patients with carcinoma developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with cisplatin, /"bleomycin"/, and a vinca alkaloid. One patient had thrombotic thrombocytopenic purpura, three the /"hemolytic-uremic syndrome"/, and one an apparent forme fruste of one of these disorders. Histologic examination of the renal tissue showed evidence of intravascular coagulation, primarily affecting the small arteries, arterioles, and glomeruli. Because each patient was tumor-free or had only a small tumor at the onset of this syndrome, the thrombotic microangiopathy may have been induced by chemotherapy. Diagnosis of this potentially fatal complication may be delayed or missed if renal tissue or the peripheral blood smear is not examined, because renal failure may be ascribed to cisplatin nephrotoxicity and the anemia and thrombocytopenia to drug-induced bone marrow suppression. Question: Does chemical /"bleomycin"/ induce disease /"hemolytic-uremic syndrome"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"vinca alkaloid"/ induces disease /"thrombotic thrombocytopenic purpura"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. - Abstract: Five patients with carcinoma developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with cisplatin, bleomycin, and a /"vinca alkaloid"/. One patient had /"thrombotic thrombocytopenic purpura"/, three the hemolytic-uremic syndrome, and one an apparent forme fruste of one of these disorders. Histologic examination of the renal tissue showed evidence of intravascular coagulation, primarily affecting the small arteries, arterioles, and glomeruli. Because each patient was tumor-free or had only a small tumor at the onset of this syndrome, the thrombotic microangiopathy may have been induced by chemotherapy. Diagnosis of this potentially fatal complication may be delayed or missed if renal tissue or the peripheral blood smear is not examined, because renal failure may be ascribed to cisplatin nephrotoxicity and the anemia and thrombocytopenia to drug-induced bone marrow suppression. Question: Does chemical /"vinca alkaloid"/ induce disease /"thrombotic thrombocytopenic purpura"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"cisplatin"/ induces disease /"hemolytic-uremic syndrome"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. - Abstract: Five patients with carcinoma developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with /"cisplatin"/, bleomycin, and a vinca alkaloid. One patient had thrombotic thrombocytopenic purpura, three the /"hemolytic-uremic syndrome"/, and one an apparent forme fruste of one of these disorders. Histologic examination of the renal tissue showed evidence of intravascular coagulation, primarily affecting the small arteries, arterioles, and glomeruli. Because each patient was tumor-free or had only a small tumor at the onset of this syndrome, the thrombotic microangiopathy may have been induced by chemotherapy. Diagnosis of this potentially fatal complication may be delayed or missed if renal tissue or the peripheral blood smear is not examined, because renal failure may be ascribed to /"cisplatin"/ nephrotoxicity and the anemia and thrombocytopenia to drug-induced bone marrow suppression. Question: Does chemical /"cisplatin"/ induce disease /"hemolytic-uremic syndrome"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"bleomycin"/ induces disease /"nephrotoxicity"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. - Abstract: Five patients with carcinoma developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with cisplatin, /"bleomycin"/, and a vinca alkaloid. One patient had thrombotic thrombocytopenic purpura, three the hemolytic-uremic syndrome, and one an apparent forme fruste of one of these disorders. Histologic examination of the renal tissue showed evidence of intravascular coagulation, primarily affecting the small arteries, arterioles, and glomeruli. Because each patient was tumor-free or had only a small tumor at the onset of this syndrome, the thrombotic microangiopathy may have been induced by chemotherapy. Diagnosis of this potentially fatal complication may be delayed or missed if renal tissue or the peripheral blood smear is not examined, because renal failure may be ascribed to cisplatin /"nephrotoxicity"/ and the anemia and thrombocytopenia to drug-induced bone marrow suppression. Question: Does chemical /"bleomycin"/ induce disease /"nephrotoxicity"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"cisplatin"/ induces disease /"carcinoma"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. - Abstract: Five patients with /"carcinoma"/ developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with /"cisplatin"/, bleomycin, and a vinca alkaloid. One patient had thrombotic thrombocytopenic purpura, three the hemolytic-uremic syndrome, and one an apparent forme fruste of one of these disorders. Histologic examination of the renal tissue showed evidence of intravascular coagulation, primarily affecting the small arteries, arterioles, and glomeruli. Because each patient was tumor-free or had only a small tumor at the onset of this syndrome, the thrombotic microangiopathy may have been induced by chemotherapy. Diagnosis of this potentially fatal complication may be delayed or missed if renal tissue or the peripheral blood smear is not examined, because renal failure may be ascribed to /"cisplatin"/ nephrotoxicity and the anemia and thrombocytopenia to drug-induced bone marrow suppression. Question: Does chemical /"cisplatin"/ induce disease /"carcinoma"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"bleomycin"/ induces disease /"Thrombotic microangiopathy"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Thrombotic microangiopathy"/ and renal failure associated with antineoplastic chemotherapy. - Abstract: Five patients with carcinoma developed /"thrombotic microangiopathy"/ (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with cisplatin, /"bleomycin"/, and a vinca alkaloid. One patient had thrombotic thrombocytopenic purpura, three the hemolytic-uremic syndrome, and one an apparent forme fruste of one of these disorders. Histologic examination of the renal tissue showed evidence of intravascular coagulation, primarily affecting the small arteries, arterioles, and glomeruli. Because each patient was tumor-free or had only a small tumor at the onset of this syndrome, the /"thrombotic microangiopathy"/ may have been induced by chemotherapy. Diagnosis of this potentially fatal complication may be delayed or missed if renal tissue or the peripheral blood smear is not examined, because renal failure may be ascribed to cisplatin nephrotoxicity and the anemia and thrombocytopenia to drug-induced bone marrow suppression. Question: Does chemical /"bleomycin"/ induce disease /"Thrombotic microangiopathy"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"vinca alkaloid"/ induces disease /"bone marrow suppression"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. - Abstract: Five patients with carcinoma developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with cisplatin, bleomycin, and a /"vinca alkaloid"/. One patient had thrombotic thrombocytopenic purpura, three the hemolytic-uremic syndrome, and one an apparent forme fruste of one of these disorders. Histologic examination of the renal tissue showed evidence of intravascular coagulation, primarily affecting the small arteries, arterioles, and glomeruli. Because each patient was tumor-free or had only a small tumor at the onset of this syndrome, the thrombotic microangiopathy may have been induced by chemotherapy. Diagnosis of this potentially fatal complication may be delayed or missed if renal tissue or the peripheral blood smear is not examined, because renal failure may be ascribed to cisplatin nephrotoxicity and the anemia and thrombocytopenia to drug-induced /"bone marrow suppression"/. Question: Does chemical /"vinca alkaloid"/ induce disease /"bone marrow suppression"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"vinca alkaloid"/ induces disease /"carcinoma"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. - Abstract: Five patients with /"carcinoma"/ developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with cisplatin, bleomycin, and a /"vinca alkaloid"/. One patient had thrombotic thrombocytopenic purpura, three the hemolytic-uremic syndrome, and one an apparent forme fruste of one of these disorders. Histologic examination of the renal tissue showed evidence of intravascular coagulation, primarily affecting the small arteries, arterioles, and glomeruli. Because each patient was tumor-free or had only a small tumor at the onset of this syndrome, the thrombotic microangiopathy may have been induced by chemotherapy. Diagnosis of this potentially fatal complication may be delayed or missed if renal tissue or the peripheral blood smear is not examined, because renal failure may be ascribed to cisplatin nephrotoxicity and the anemia and thrombocytopenia to drug-induced bone marrow suppression. Question: Does chemical /"vinca alkaloid"/ induce disease /"carcinoma"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"bleomycin"/ induces disease /"bone marrow suppression"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. - Abstract: Five patients with carcinoma developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with cisplatin, /"bleomycin"/, and a vinca alkaloid. One patient had thrombotic thrombocytopenic purpura, three the hemolytic-uremic syndrome, and one an apparent forme fruste of one of these disorders. Histologic examination of the renal tissue showed evidence of intravascular coagulation, primarily affecting the small arteries, arterioles, and glomeruli. Because each patient was tumor-free or had only a small tumor at the onset of this syndrome, the thrombotic microangiopathy may have been induced by chemotherapy. Diagnosis of this potentially fatal complication may be delayed or missed if renal tissue or the peripheral blood smear is not examined, because renal failure may be ascribed to cisplatin nephrotoxicity and the anemia and thrombocytopenia to drug-induced /"bone marrow suppression"/. Question: Does chemical /"bleomycin"/ induce disease /"bone marrow suppression"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"cisplatin"/ induces disease /"thrombocytopenia"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. - Abstract: Five patients with carcinoma developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually /"thrombocytopenia"/) after treatment with /"cisplatin"/, bleomycin, and a vinca alkaloid. One patient had thrombotic thrombocytopenic purpura, three the hemolytic-uremic syndrome, and one an apparent forme fruste of one of these disorders. Histologic examination of the renal tissue showed evidence of intravascular coagulation, primarily affecting the small arteries, arterioles, and glomeruli. Because each patient was tumor-free or had only a small tumor at the onset of this syndrome, the thrombotic microangiopathy may have been induced by chemotherapy. Diagnosis of this potentially fatal complication may be delayed or missed if renal tissue or the peripheral blood smear is not examined, because renal failure may be ascribed to /"cisplatin"/ nephrotoxicity and the anemia and /"thrombocytopenia"/ to drug-induced bone marrow suppression. Question: Does chemical /"cisplatin"/ induce disease /"thrombocytopenia"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"cisplatin"/ induces disease /"renal failure"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Thrombotic microangiopathy and /"renal failure"/ associated with antineoplastic chemotherapy. - Abstract: Five patients with carcinoma developed thrombotic microangiopathy (characterized by /"renal insufficiency"/, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with /"cisplatin"/, bleomycin, and a vinca alkaloid. One patient had thrombotic thrombocytopenic purpura, three the hemolytic-uremic syndrome, and one an apparent forme fruste of one of these disorders. Histologic examination of the renal tissue showed evidence of intravascular coagulation, primarily affecting the small arteries, arterioles, and glomeruli. Because each patient was tumor-free or had only a small tumor at the onset of this syndrome, the thrombotic microangiopathy may have been induced by chemotherapy. Diagnosis of this potentially fatal complication may be delayed or missed if renal tissue or the peripheral blood smear is not examined, because /"renal failure"/ may be ascribed to /"cisplatin"/ nephrotoxicity and the anemia and thrombocytopenia to drug-induced bone marrow suppression. Question: Does chemical /"cisplatin"/ induce disease /"renal failure"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"vinca alkaloid"/ induces disease /"tumor"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. - Abstract: Five patients with carcinoma developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with cisplatin, bleomycin, and a /"vinca alkaloid"/. One patient had thrombotic thrombocytopenic purpura, three the hemolytic-uremic syndrome, and one an apparent forme fruste of one of these disorders. Histologic examination of the renal tissue showed evidence of intravascular coagulation, primarily affecting the small arteries, arterioles, and glomeruli. Because each patient was /"tumor"/-free or had only a small /"tumor"/ at the onset of this syndrome, the thrombotic microangiopathy may have been induced by chemotherapy. Diagnosis of this potentially fatal complication may be delayed or missed if renal tissue or the peripheral blood smear is not examined, because renal failure may be ascribed to cisplatin nephrotoxicity and the anemia and thrombocytopenia to drug-induced bone marrow suppression. Question: Does chemical /"vinca alkaloid"/ induce disease /"tumor"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"bleomycin"/ induces disease /"intravascular coagulation"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. - Abstract: Five patients with carcinoma developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with cisplatin, /"bleomycin"/, and a vinca alkaloid. One patient had thrombotic thrombocytopenic purpura, three the hemolytic-uremic syndrome, and one an apparent forme fruste of one of these disorders. Histologic examination of the renal tissue showed evidence of /"intravascular coagulation"/, primarily affecting the small arteries, arterioles, and glomeruli. Because each patient was tumor-free or had only a small tumor at the onset of this syndrome, the thrombotic microangiopathy may have been induced by chemotherapy. Diagnosis of this potentially fatal complication may be delayed or missed if renal tissue or the peripheral blood smear is not examined, because renal failure may be ascribed to cisplatin nephrotoxicity and the anemia and thrombocytopenia to drug-induced bone marrow suppression. Question: Does chemical /"bleomycin"/ induce disease /"intravascular coagulation"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"nelarabine"/ induces disease /"neuropathy"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Salvage therapy with /"nelarabine"/, etoposide, and cyclophosphamide in relapsed/refractory paediatric T-cell lymphoblastic leukaemia and lymphoma. - Abstract: A combination of 5 d of /"nelarabine"/ (/"AraG"/) with 5 d of etoposide (VP) and cyclophosphamide (CPM) and prophylactic intrathecal chemotherapy was used as salvage therapy in seven children with refractory or relapsed T-cell leukaemia or lymphoma. The most common side effects attributable to the /"AraG"/ included Grade 2 and 3 sensory and motor /"neuropathy"/ and musculoskeletal pain. Haematological toxicity was greater for the combination than /"AraG"/ alone, although median time to neutrophil and platelet recovery was consistent with other salvage therapies. All patients had some response to the combined therapy and five of the seven went into complete remission after one or two courses of /"AraG"//VP/CPM. Our experience supports the safety of giving /"AraG"/ as salvage therapy in synchrony with etoposide and cyclophosphamide, although /"neurological toxicity"/ must be closely monitored. Question: Does chemical /"nelarabine"/ induce disease /"neuropathy"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"nelarabine"/ induces disease /"Haematological toxicity"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Salvage therapy with /"nelarabine"/, etoposide, and cyclophosphamide in relapsed/refractory paediatric T-cell lymphoblastic leukaemia and lymphoma. - Abstract: A combination of 5 d of /"nelarabine"/ (/"AraG"/) with 5 d of etoposide (VP) and cyclophosphamide (CPM) and prophylactic intrathecal chemotherapy was used as salvage therapy in seven children with refractory or relapsed T-cell leukaemia or lymphoma. The most common side effects attributable to the /"AraG"/ included Grade 2 and 3 sensory and motor neuropathy and musculoskeletal pain. /"Haematological toxicity"/ was greater for the combination than /"AraG"/ alone, although median time to neutrophil and platelet recovery was consistent with other salvage therapies. All patients had some response to the combined therapy and five of the seven went into complete remission after one or two courses of /"AraG"//VP/CPM. Our experience supports the safety of giving /"AraG"/ as salvage therapy in synchrony with etoposide and cyclophosphamide, although neurological toxicity must be closely monitored. Question: Does chemical /"nelarabine"/ induce disease /"Haematological toxicity"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"nelarabine"/ induces disease /"musculoskeletal pain"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Salvage therapy with /"nelarabine"/, etoposide, and cyclophosphamide in relapsed/refractory paediatric T-cell lymphoblastic leukaemia and lymphoma. - Abstract: A combination of 5 d of /"nelarabine"/ (/"AraG"/) with 5 d of etoposide (VP) and cyclophosphamide (CPM) and prophylactic intrathecal chemotherapy was used as salvage therapy in seven children with refractory or relapsed T-cell leukaemia or lymphoma. The most common side effects attributable to the /"AraG"/ included Grade 2 and 3 sensory and motor neuropathy and /"musculoskeletal pain"/. Haematological toxicity was greater for the combination than /"AraG"/ alone, although median time to neutrophil and platelet recovery was consistent with other salvage therapies. All patients had some response to the combined therapy and five of the seven went into complete remission after one or two courses of /"AraG"//VP/CPM. Our experience supports the safety of giving /"AraG"/ as salvage therapy in synchrony with etoposide and cyclophosphamide, although neurological toxicity must be closely monitored. Question: Does chemical /"nelarabine"/ induce disease /"musculoskeletal pain"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"cyclophosphamide"/ induces disease /"Haematological toxicity"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Salvage therapy with nelarabine, etoposide, and /"cyclophosphamide"/ in relapsed/refractory paediatric T-cell lymphoblastic leukaemia and lymphoma. - Abstract: A combination of 5 d of nelarabine (AraG) with 5 d of etoposide (VP) and /"cyclophosphamide"/ (/"CPM"/) and prophylactic intrathecal chemotherapy was used as salvage therapy in seven children with refractory or relapsed T-cell leukaemia or lymphoma. The most common side effects attributable to the AraG included Grade 2 and 3 sensory and motor neuropathy and musculoskeletal pain. /"Haematological toxicity"/ was greater for the combination than AraG alone, although median time to neutrophil and platelet recovery was consistent with other salvage therapies. All patients had some response to the combined therapy and five of the seven went into complete remission after one or two courses of AraG/VP//"CPM"/. Our experience supports the safety of giving AraG as salvage therapy in synchrony with etoposide and /"cyclophosphamide"/, although neurological toxicity must be closely monitored. Question: Does chemical /"cyclophosphamide"/ induce disease /"Haematological toxicity"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"etoposide"/ induces disease /"T-cell lymphoblastic leukaemia and lymphoma"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Salvage therapy with nelarabine, /"etoposide"/, and cyclophosphamide in relapsed/refractory paediatric /"T-cell lymphoblastic leukaemia and lymphoma"/. - Abstract: A combination of 5 d of nelarabine (AraG) with 5 d of /"etoposide"/ (/"VP"/) and cyclophosphamide (CPM) and prophylactic intrathecal chemotherapy was used as salvage therapy in seven children with refractory or relapsed /"T-cell leukaemia or lymphoma"/. The most common side effects attributable to the AraG included Grade 2 and 3 sensory and motor neuropathy and musculoskeletal pain. Haematological toxicity was greater for the combination than AraG alone, although median time to neutrophil and platelet recovery was consistent with other salvage therapies. All patients had some response to the combined therapy and five of the seven went into complete remission after one or two courses of AraG//"VP"//CPM. Our experience supports the safety of giving AraG as salvage therapy in synchrony with /"etoposide"/ and cyclophosphamide, although neurological toxicity must be closely monitored. Question: Does chemical /"etoposide"/ induce disease /"T-cell lymphoblastic leukaemia and lymphoma"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"cyclophosphamide"/ induces disease /"T-cell lymphoblastic leukaemia"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Salvage therapy with nelarabine, etoposide, and /"cyclophosphamide"/ in relapsed/refractory paediatric /"T-cell lymphoblastic leukaemia"/ and lymphoma. - Abstract: A combination of 5 d of nelarabine (AraG) with 5 d of etoposide (VP) and /"cyclophosphamide"/ (/"CPM"/) and prophylactic intrathecal chemotherapy was used as salvage therapy in seven children with refractory or relapsed /"T-cell leukaemia"/ or lymphoma. The most common side effects attributable to the AraG included Grade 2 and 3 sensory and motor neuropathy and musculoskeletal pain. Haematological toxicity was greater for the combination than AraG alone, although median time to neutrophil and platelet recovery was consistent with other salvage therapies. All patients had some response to the combined therapy and five of the seven went into complete remission after one or two courses of AraG/VP//"CPM"/. Our experience supports the safety of giving AraG as salvage therapy in synchrony with etoposide and /"cyclophosphamide"/, although neurological toxicity must be closely monitored. Question: Does chemical /"cyclophosphamide"/ induce disease /"T-cell lymphoblastic leukaemia"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"sulphasalazine"/ induces disease /"fever"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: The 3-week /"sulphasalazine"/ syndrome strikes again. - Abstract: A 34-year-old lady developed a constellation of dermatitis, /"fever"/, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral /"sulphasalazine"/ for sero-negative rheumatoid arthritis. Cervical and inguinal lymph node biopsies showed the features of severe necrotising lymphadenitis, associated with erythrophagocytosis and prominent eosinophilic infiltrates, without viral inclusion bodies, suggestive of an adverse drug reaction.A week later, fulminant drug-induced hepatitis, associated with the presence of anti-nuclear autoantibodies (but not with other markers of autoimmunity), and accompanied by multi-organ failure and sepsis, supervened. She subsequently died some 5 weeks after the commencement of her drug therapy.Post-mortem examination showed evidence of massive hepatocellular necrosis, acute hypersensitivity myocarditis, focal acute tubulo-interstitial nephritis and extensive bone marrow necrosis, with no evidence of malignancy. It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week /"sulphasalazine"/ syndrome", a rare, but often fatal, immunoallergic reaction to /"sulphasalazine"/. Question: Does chemical /"sulphasalazine"/ induce disease /"fever"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"sulphasalazine"/ induces disease /"myocarditis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: The 3-week /"sulphasalazine"/ syndrome strikes again. - Abstract: A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral /"sulphasalazine"/ for sero-negative rheumatoid arthritis. Cervical and inguinal lymph node biopsies showed the features of severe necrotising lymphadenitis, associated with erythrophagocytosis and prominent eosinophilic infiltrates, without viral inclusion bodies, suggestive of an adverse drug reaction.A week later, fulminant drug-induced hepatitis, associated with the presence of anti-nuclear autoantibodies (but not with other markers of autoimmunity), and accompanied by multi-organ failure and sepsis, supervened. She subsequently died some 5 weeks after the commencement of her drug therapy.Post-mortem examination showed evidence of massive hepatocellular necrosis, acute hypersensitivity /"myocarditis"/, focal acute tubulo-interstitial nephritis and extensive bone marrow necrosis, with no evidence of malignancy. It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week /"sulphasalazine"/ syndrome", a rare, but often fatal, immunoallergic reaction to /"sulphasalazine"/. Question: Does chemical /"sulphasalazine"/ induce disease /"myocarditis"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"sulphasalazine"/ induces disease /"lymphadenopathy"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: The 3-week /"sulphasalazine"/ syndrome strikes again. - Abstract: A 34-year-old lady developed a constellation of dermatitis, fever, /"lymphadenopathy"/ and hepatitis, beginning on the 17th day of a course of oral /"sulphasalazine"/ for sero-negative rheumatoid arthritis. Cervical and inguinal lymph node biopsies showed the features of severe necrotising lymphadenitis, associated with erythrophagocytosis and prominent eosinophilic infiltrates, without viral inclusion bodies, suggestive of an adverse drug reaction.A week later, fulminant drug-induced hepatitis, associated with the presence of anti-nuclear autoantibodies (but not with other markers of autoimmunity), and accompanied by multi-organ failure and sepsis, supervened. She subsequently died some 5 weeks after the commencement of her drug therapy.Post-mortem examination showed evidence of massive hepatocellular necrosis, acute hypersensitivity myocarditis, focal acute tubulo-interstitial nephritis and extensive bone marrow necrosis, with no evidence of malignancy. It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week /"sulphasalazine"/ syndrome", a rare, but often fatal, immunoallergic reaction to /"sulphasalazine"/. Question: Does chemical /"sulphasalazine"/ induce disease /"lymphadenopathy"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"sulphasalazine"/ induces disease /"sepsis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: The 3-week /"sulphasalazine"/ syndrome strikes again. - Abstract: A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral /"sulphasalazine"/ for sero-negative rheumatoid arthritis. Cervical and inguinal lymph node biopsies showed the features of severe necrotising lymphadenitis, associated with erythrophagocytosis and prominent eosinophilic infiltrates, without viral inclusion bodies, suggestive of an adverse drug reaction.A week later, fulminant drug-induced hepatitis, associated with the presence of anti-nuclear autoantibodies (but not with other markers of autoimmunity), and accompanied by multi-organ failure and /"sepsis"/, supervened. She subsequently died some 5 weeks after the commencement of her drug therapy.Post-mortem examination showed evidence of massive hepatocellular necrosis, acute hypersensitivity myocarditis, focal acute tubulo-interstitial nephritis and extensive bone marrow necrosis, with no evidence of malignancy. It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week /"sulphasalazine"/ syndrome", a rare, but often fatal, immunoallergic reaction to /"sulphasalazine"/. Question: Does chemical /"sulphasalazine"/ induce disease /"sepsis"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"sulphasalazine"/ induces disease /"nephritis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: The 3-week /"sulphasalazine"/ syndrome strikes again. - Abstract: A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral /"sulphasalazine"/ for sero-negative rheumatoid arthritis. Cervical and inguinal lymph node biopsies showed the features of severe necrotising lymphadenitis, associated with erythrophagocytosis and prominent eosinophilic infiltrates, without viral inclusion bodies, suggestive of an adverse drug reaction.A week later, fulminant drug-induced hepatitis, associated with the presence of anti-nuclear autoantibodies (but not with other markers of autoimmunity), and accompanied by multi-organ failure and sepsis, supervened. She subsequently died some 5 weeks after the commencement of her drug therapy.Post-mortem examination showed evidence of massive hepatocellular necrosis, acute hypersensitivity myocarditis, focal acute tubulo-interstitial /"nephritis"/ and extensive bone marrow necrosis, with no evidence of malignancy. It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week /"sulphasalazine"/ syndrome", a rare, but often fatal, immunoallergic reaction to /"sulphasalazine"/. Question: Does chemical /"sulphasalazine"/ induce disease /"nephritis"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"sulphasalazine"/ induces disease /"dermatitis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: The 3-week /"sulphasalazine"/ syndrome strikes again. - Abstract: A 34-year-old lady developed a constellation of /"dermatitis"/, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral /"sulphasalazine"/ for sero-negative rheumatoid arthritis. Cervical and inguinal lymph node biopsies showed the features of severe necrotising lymphadenitis, associated with erythrophagocytosis and prominent eosinophilic infiltrates, without viral inclusion bodies, suggestive of an adverse drug reaction.A week later, fulminant drug-induced hepatitis, associated with the presence of anti-nuclear autoantibodies (but not with other markers of autoimmunity), and accompanied by multi-organ failure and sepsis, supervened. She subsequently died some 5 weeks after the commencement of her drug therapy.Post-mortem examination showed evidence of massive hepatocellular necrosis, acute hypersensitivity myocarditis, focal acute tubulo-interstitial nephritis and extensive bone marrow necrosis, with no evidence of malignancy. It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week /"sulphasalazine"/ syndrome", a rare, but often fatal, immunoallergic reaction to /"sulphasalazine"/. Question: Does chemical /"sulphasalazine"/ induce disease /"dermatitis"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"sulphasalazine"/ induces disease /"hepatitis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: The 3-week /"sulphasalazine"/ syndrome strikes again. - Abstract: A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and /"hepatitis"/, beginning on the 17th day of a course of oral /"sulphasalazine"/ for sero-negative rheumatoid arthritis. Cervical and inguinal lymph node biopsies showed the features of severe necrotising lymphadenitis, associated with erythrophagocytosis and prominent eosinophilic infiltrates, without viral inclusion bodies, suggestive of an adverse drug reaction.A week later, fulminant /"drug-induced hepatitis"/, associated with the presence of anti-nuclear autoantibodies (but not with other markers of autoimmunity), and accompanied by multi-organ failure and sepsis, supervened. She subsequently died some 5 weeks after the commencement of her drug therapy.Post-mortem examination showed evidence of massive hepatocellular necrosis, acute hypersensitivity myocarditis, focal acute tubulo-interstitial nephritis and extensive bone marrow necrosis, with no evidence of malignancy. It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week /"sulphasalazine"/ syndrome", a rare, but often fatal, immunoallergic reaction to /"sulphasalazine"/. Question: Does chemical /"sulphasalazine"/ induce disease /"hepatitis"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"sulphasalazine"/ induces disease /"adverse drug reaction"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: The 3-week /"sulphasalazine"/ syndrome strikes again. - Abstract: A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral /"sulphasalazine"/ for sero-negative rheumatoid arthritis. Cervical and inguinal lymph node biopsies showed the features of severe necrotising lymphadenitis, associated with erythrophagocytosis and prominent eosinophilic infiltrates, without viral inclusion bodies, suggestive of an /"adverse drug reaction"/.A week later, fulminant drug-induced hepatitis, associated with the presence of anti-nuclear autoantibodies (but not with other markers of autoimmunity), and accompanied by multi-organ failure and sepsis, supervened. She subsequently died some 5 weeks after the commencement of her drug therapy.Post-mortem examination showed evidence of massive hepatocellular necrosis, acute hypersensitivity myocarditis, focal acute tubulo-interstitial nephritis and extensive bone marrow necrosis, with no evidence of malignancy. It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week /"sulphasalazine"/ syndrome", a rare, but often fatal, immunoallergic reaction to /"sulphasalazine"/. Question: Does chemical /"sulphasalazine"/ induce disease /"adverse drug reaction"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"sulphasalazine"/ induces disease /"lymphadenitis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: The 3-week /"sulphasalazine"/ syndrome strikes again. - Abstract: A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral /"sulphasalazine"/ for sero-negative rheumatoid arthritis. Cervical and inguinal lymph node biopsies showed the features of severe necrotising /"lymphadenitis"/, associated with erythrophagocytosis and prominent eosinophilic infiltrates, without viral inclusion bodies, suggestive of an adverse drug reaction.A week later, fulminant drug-induced hepatitis, associated with the presence of anti-nuclear autoantibodies (but not with other markers of autoimmunity), and accompanied by multi-organ failure and sepsis, supervened. She subsequently died some 5 weeks after the commencement of her drug therapy.Post-mortem examination showed evidence of massive hepatocellular necrosis, acute hypersensitivity myocarditis, focal acute tubulo-interstitial nephritis and extensive bone marrow necrosis, with no evidence of malignancy. It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week /"sulphasalazine"/ syndrome", a rare, but often fatal, immunoallergic reaction to /"sulphasalazine"/. Question: Does chemical /"sulphasalazine"/ induce disease /"lymphadenitis"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"sulphasalazine"/ induces disease /"multi-organ failure"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: The 3-week /"sulphasalazine"/ syndrome strikes again. - Abstract: A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral /"sulphasalazine"/ for sero-negative rheumatoid arthritis. Cervical and inguinal lymph node biopsies showed the features of severe necrotising lymphadenitis, associated with erythrophagocytosis and prominent eosinophilic infiltrates, without viral inclusion bodies, suggestive of an adverse drug reaction.A week later, fulminant drug-induced hepatitis, associated with the presence of anti-nuclear autoantibodies (but not with other markers of autoimmunity), and accompanied by /"multi-organ failure"/ and sepsis, supervened. She subsequently died some 5 weeks after the commencement of her drug therapy.Post-mortem examination showed evidence of massive hepatocellular necrosis, acute hypersensitivity myocarditis, focal acute tubulo-interstitial nephritis and extensive bone marrow necrosis, with no evidence of malignancy. It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week /"sulphasalazine"/ syndrome", a rare, but often fatal, immunoallergic reaction to /"sulphasalazine"/. Question: Does chemical /"sulphasalazine"/ induce disease /"multi-organ failure"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"sulphasalazine"/ induces disease /"autoimmunity"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: The 3-week /"sulphasalazine"/ syndrome strikes again. - Abstract: A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral /"sulphasalazine"/ for sero-negative rheumatoid arthritis. Cervical and inguinal lymph node biopsies showed the features of severe necrotising lymphadenitis, associated with erythrophagocytosis and prominent eosinophilic infiltrates, without viral inclusion bodies, suggestive of an adverse drug reaction.A week later, fulminant drug-induced hepatitis, associated with the presence of anti-nuclear autoantibodies (but not with other markers of /"autoimmunity"/), and accompanied by multi-organ failure and sepsis, supervened. She subsequently died some 5 weeks after the commencement of her drug therapy.Post-mortem examination showed evidence of massive hepatocellular necrosis, acute hypersensitivity myocarditis, focal acute tubulo-interstitial nephritis and extensive bone marrow necrosis, with no evidence of malignancy. It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week /"sulphasalazine"/ syndrome", a rare, but often fatal, immunoallergic reaction to /"sulphasalazine"/. Question: Does chemical /"sulphasalazine"/ induce disease /"autoimmunity"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"sulphasalazine"/ induces disease /"malignancy"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: The 3-week /"sulphasalazine"/ syndrome strikes again. - Abstract: A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral /"sulphasalazine"/ for sero-negative rheumatoid arthritis. Cervical and inguinal lymph node biopsies showed the features of severe necrotising lymphadenitis, associated with erythrophagocytosis and prominent eosinophilic infiltrates, without viral inclusion bodies, suggestive of an adverse drug reaction.A week later, fulminant drug-induced hepatitis, associated with the presence of anti-nuclear autoantibodies (but not with other markers of autoimmunity), and accompanied by multi-organ failure and sepsis, supervened. She subsequently died some 5 weeks after the commencement of her drug therapy.Post-mortem examination showed evidence of massive hepatocellular necrosis, acute hypersensitivity myocarditis, focal acute tubulo-interstitial nephritis and extensive bone marrow necrosis, with no evidence of /"malignancy"/. It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week /"sulphasalazine"/ syndrome", a rare, but often fatal, immunoallergic reaction to /"sulphasalazine"/. Question: Does chemical /"sulphasalazine"/ induce disease /"malignancy"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"sulphasalazine"/ induces disease /"bone marrow necrosis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: The 3-week /"sulphasalazine"/ syndrome strikes again. - Abstract: A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral /"sulphasalazine"/ for sero-negative rheumatoid arthritis. Cervical and inguinal lymph node biopsies showed the features of severe necrotising lymphadenitis, associated with erythrophagocytosis and prominent eosinophilic infiltrates, without viral inclusion bodies, suggestive of an adverse drug reaction.A week later, fulminant drug-induced hepatitis, associated with the presence of anti-nuclear autoantibodies (but not with other markers of autoimmunity), and accompanied by multi-organ failure and sepsis, supervened. She subsequently died some 5 weeks after the commencement of her drug therapy.Post-mortem examination showed evidence of massive hepatocellular necrosis, acute hypersensitivity myocarditis, focal acute tubulo-interstitial nephritis and extensive /"bone marrow necrosis"/, with no evidence of malignancy. It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week /"sulphasalazine"/ syndrome", a rare, but often fatal, immunoallergic reaction to /"sulphasalazine"/. Question: Does chemical /"sulphasalazine"/ induce disease /"bone marrow necrosis"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"sulphasalazine"/ induces disease /"massive hepatocellular necrosis"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: The 3-week /"sulphasalazine"/ syndrome strikes again. - Abstract: A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral /"sulphasalazine"/ for sero-negative rheumatoid arthritis. Cervical and inguinal lymph node biopsies showed the features of severe necrotising lymphadenitis, associated with erythrophagocytosis and prominent eosinophilic infiltrates, without viral inclusion bodies, suggestive of an adverse drug reaction.A week later, fulminant drug-induced hepatitis, associated with the presence of anti-nuclear autoantibodies (but not with other markers of autoimmunity), and accompanied by multi-organ failure and sepsis, supervened. She subsequently died some 5 weeks after the commencement of her drug therapy.Post-mortem examination showed evidence of /"massive hepatocellular necrosis"/, acute hypersensitivity myocarditis, focal acute tubulo-interstitial nephritis and extensive bone marrow necrosis, with no evidence of malignancy. It is thought that the clinico-pathological features and chronology of this case bore the hallmarks of the so-called "3-week /"sulphasalazine"/ syndrome", a rare, but often fatal, immunoallergic reaction to /"sulphasalazine"/. Question: Does chemical /"sulphasalazine"/ induce disease /"massive hepatocellular necrosis"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Bupropion"/ induces disease /"tachycardia"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Bupropion"/ (/"Zyban"/) toxicity. - Abstract: /"Bupropion"/ is a monocyclic antidepressant structurally related to amphetamine. /"Zyban"/, a sustained-release formulation of /"bupropion hydrochloride"/, was recently released in Ireland, as a smoking cessation aid. In the initial 6 months since it's introduction, 12 overdose cases have been reported to The National Poisons Information Centre. 8 patients developed symptoms of toxicity. Common features included /"tachycardia"/, drowsiness, hallucinations and convulsions. Two patients developed severe cardiac arrhythmias, including one patient who was resuscitated following a cardiac arrest. All patients recovered without sequelae. We report a case of a 31 year old female who required admission to the Intensive Care Unit for ventilation and full supportive therapy, following ingestion of 13.5g /"bupropion"/. Recurrent seizures were treated with diazepam and broad complex /"tachycardia"/ was successfully treated with adenosine. /"Zyban"/ caused significant neurological and cardiovascular toxicity in overdose. The potential toxic effects should be considered when prescribing it as a smoking cessation aid. Question: Does chemical /"Bupropion"/ induce disease /"tachycardia"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Bupropion"/ induces disease /"convulsions"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Bupropion"/ (/"Zyban"/) toxicity. - Abstract: /"Bupropion"/ is a monocyclic antidepressant structurally related to amphetamine. /"Zyban"/, a sustained-release formulation of /"bupropion hydrochloride"/, was recently released in Ireland, as a smoking cessation aid. In the initial 6 months since it's introduction, 12 overdose cases have been reported to The National Poisons Information Centre. 8 patients developed symptoms of toxicity. Common features included tachycardia, drowsiness, hallucinations and /"convulsions"/. Two patients developed severe cardiac arrhythmias, including one patient who was resuscitated following a cardiac arrest. All patients recovered without sequelae. We report a case of a 31 year old female who required admission to the Intensive Care Unit for ventilation and full supportive therapy, following ingestion of 13.5g /"bupropion"/. Recurrent /"seizures"/ were treated with diazepam and broad complex tachycardia was successfully treated with adenosine. /"Zyban"/ caused significant neurological and cardiovascular toxicity in overdose. The potential toxic effects should be considered when prescribing it as a smoking cessation aid. Question: Does chemical /"Bupropion"/ induce disease /"convulsions"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Bupropion"/ induces disease /"hallucinations"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Bupropion"/ (/"Zyban"/) toxicity. - Abstract: /"Bupropion"/ is a monocyclic antidepressant structurally related to amphetamine. /"Zyban"/, a sustained-release formulation of /"bupropion hydrochloride"/, was recently released in Ireland, as a smoking cessation aid. In the initial 6 months since it's introduction, 12 overdose cases have been reported to The National Poisons Information Centre. 8 patients developed symptoms of toxicity. Common features included tachycardia, drowsiness, /"hallucinations"/ and convulsions. Two patients developed severe cardiac arrhythmias, including one patient who was resuscitated following a cardiac arrest. All patients recovered without sequelae. We report a case of a 31 year old female who required admission to the Intensive Care Unit for ventilation and full supportive therapy, following ingestion of 13.5g /"bupropion"/. Recurrent seizures were treated with diazepam and broad complex tachycardia was successfully treated with adenosine. /"Zyban"/ caused significant neurological and cardiovascular toxicity in overdose. The potential toxic effects should be considered when prescribing it as a smoking cessation aid. Question: Does chemical /"Bupropion"/ induce disease /"hallucinations"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Bupropion"/ induces disease /"cardiac arrhythmias"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Bupropion"/ (/"Zyban"/) toxicity. - Abstract: /"Bupropion"/ is a monocyclic antidepressant structurally related to amphetamine. /"Zyban"/, a sustained-release formulation of /"bupropion hydrochloride"/, was recently released in Ireland, as a smoking cessation aid. In the initial 6 months since it's introduction, 12 overdose cases have been reported to The National Poisons Information Centre. 8 patients developed symptoms of toxicity. Common features included tachycardia, drowsiness, hallucinations and convulsions. Two patients developed severe /"cardiac arrhythmias"/, including one patient who was resuscitated following a cardiac arrest. All patients recovered without sequelae. We report a case of a 31 year old female who required admission to the Intensive Care Unit for ventilation and full supportive therapy, following ingestion of 13.5g /"bupropion"/. Recurrent seizures were treated with diazepam and broad complex tachycardia was successfully treated with adenosine. /"Zyban"/ caused significant neurological and cardiovascular toxicity in overdose. The potential toxic effects should be considered when prescribing it as a smoking cessation aid. Question: Does chemical /"Bupropion"/ induce disease /"cardiac arrhythmias"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Bupropion"/ induces disease /"cardiac arrest"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Bupropion"/ (/"Zyban"/) toxicity. - Abstract: /"Bupropion"/ is a monocyclic antidepressant structurally related to amphetamine. /"Zyban"/, a sustained-release formulation of /"bupropion hydrochloride"/, was recently released in Ireland, as a smoking cessation aid. In the initial 6 months since it's introduction, 12 overdose cases have been reported to The National Poisons Information Centre. 8 patients developed symptoms of toxicity. Common features included tachycardia, drowsiness, hallucinations and convulsions. Two patients developed severe cardiac arrhythmias, including one patient who was resuscitated following a /"cardiac arrest"/. All patients recovered without sequelae. We report a case of a 31 year old female who required admission to the Intensive Care Unit for ventilation and full supportive therapy, following ingestion of 13.5g /"bupropion"/. Recurrent seizures were treated with diazepam and broad complex tachycardia was successfully treated with adenosine. /"Zyban"/ caused significant neurological and cardiovascular toxicity in overdose. The potential toxic effects should be considered when prescribing it as a smoking cessation aid. Question: Does chemical /"Bupropion"/ induce disease /"cardiac arrest"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"Bupropion"/ induces disease /"neurological"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Bupropion"/ (/"Zyban"/) toxicity. - Abstract: /"Bupropion"/ is a monocyclic antidepressant structurally related to amphetamine. /"Zyban"/, a sustained-release formulation of /"bupropion hydrochloride"/, was recently released in Ireland, as a smoking cessation aid. In the initial 6 months since it's introduction, 12 overdose cases have been reported to The National Poisons Information Centre. 8 patients developed symptoms of toxicity. Common features included tachycardia, drowsiness, hallucinations and convulsions. Two patients developed severe cardiac arrhythmias, including one patient who was resuscitated following a cardiac arrest. All patients recovered without sequelae. We report a case of a 31 year old female who required admission to the Intensive Care Unit for ventilation and full supportive therapy, following ingestion of 13.5g /"bupropion"/. Recurrent seizures were treated with diazepam and broad complex tachycardia was successfully treated with adenosine. /"Zyban"/ caused significant /"neurological"/ and cardiovascular /"neurological"/ in overdose. The potential toxic effects should be considered when prescribing it as a smoking cessation aid. Question: Does chemical /"Bupropion"/ induce disease /"neurological"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"antidepressant"/ induces disease /"toxicity"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Bupropion (Zyban) /"toxicity"/. - Abstract: Bupropion is a monocyclic /"antidepressant"/ structurally related to amphetamine. Zyban, a sustained-release formulation of bupropion hydrochloride, was recently released in Ireland, as a smoking cessation aid. In the initial 6 months since it's introduction, 12 overdose cases have been reported to The National Poisons Information Centre. 8 patients developed symptoms of /"toxicity"/. Common features included tachycardia, drowsiness, hallucinations and convulsions. Two patients developed severe cardiac arrhythmias, including one patient who was resuscitated following a cardiac arrest. All patients recovered without sequelae. We report a case of a 31 year old female who required admission to the Intensive Care Unit for ventilation and full supportive therapy, following ingestion of 13.5g bupropion. Recurrent seizures were treated with diazepam and broad complex tachycardia was successfully treated with adenosine. Zyban caused significant neurological and cardiovascular toxicity in overdose. The potential toxic effects should be considered when prescribing it as a smoking cessation aid. Question: Does chemical /"antidepressant"/ induce disease /"toxicity"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"diazepam"/ induces disease /"cardiac arrhythmias"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Bupropion (Zyban) toxicity. - Abstract: Bupropion is a monocyclic antidepressant structurally related to amphetamine. Zyban, a sustained-release formulation of bupropion hydrochloride, was recently released in Ireland, as a smoking cessation aid. In the initial 6 months since it's introduction, 12 overdose cases have been reported to The National Poisons Information Centre. 8 patients developed symptoms of toxicity. Common features included tachycardia, drowsiness, hallucinations and convulsions. Two patients developed severe /"cardiac arrhythmias"/, including one patient who was resuscitated following a cardiac arrest. All patients recovered without sequelae. We report a case of a 31 year old female who required admission to the Intensive Care Unit for ventilation and full supportive therapy, following ingestion of 13.5g bupropion. Recurrent seizures were treated with /"diazepam"/ and broad complex tachycardia was successfully treated with adenosine. Zyban caused significant neurological and cardiovascular toxicity in overdose. The potential toxic effects should be considered when prescribing it as a smoking cessation aid. Question: Does chemical /"diazepam"/ induce disease /"cardiac arrhythmias"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"diazepam"/ induces disease /"tachycardia"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Bupropion (Zyban) toxicity. - Abstract: Bupropion is a monocyclic antidepressant structurally related to amphetamine. Zyban, a sustained-release formulation of bupropion hydrochloride, was recently released in Ireland, as a smoking cessation aid. In the initial 6 months since it's introduction, 12 overdose cases have been reported to The National Poisons Information Centre. 8 patients developed symptoms of toxicity. Common features included /"tachycardia"/, drowsiness, hallucinations and convulsions. Two patients developed severe cardiac arrhythmias, including one patient who was resuscitated following a cardiac arrest. All patients recovered without sequelae. We report a case of a 31 year old female who required admission to the Intensive Care Unit for ventilation and full supportive therapy, following ingestion of 13.5g bupropion. Recurrent seizures were treated with /"diazepam"/ and broad complex /"tachycardia"/ was successfully treated with adenosine. Zyban caused significant neurological and cardiovascular toxicity in overdose. The potential toxic effects should be considered when prescribing it as a smoking cessation aid. Question: Does chemical /"diazepam"/ induce disease /"tachycardia"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"adenosine"/ induces disease /"neurological and cardiovascular toxicity"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Bupropion (Zyban) toxicity. - Abstract: Bupropion is a monocyclic antidepressant structurally related to amphetamine. Zyban, a sustained-release formulation of bupropion hydrochloride, was recently released in Ireland, as a smoking cessation aid. In the initial 6 months since it's introduction, 12 overdose cases have been reported to The National Poisons Information Centre. 8 patients developed symptoms of toxicity. Common features included tachycardia, drowsiness, hallucinations and convulsions. Two patients developed severe cardiac arrhythmias, including one patient who was resuscitated following a cardiac arrest. All patients recovered without sequelae. We report a case of a 31 year old female who required admission to the Intensive Care Unit for ventilation and full supportive therapy, following ingestion of 13.5g bupropion. Recurrent seizures were treated with diazepam and broad complex tachycardia was successfully treated with /"adenosine"/. Zyban caused significant /"neurological and cardiovascular toxicity"/ in overdose. The potential toxic effects should be considered when prescribing it as a smoking cessation aid. Question: Does chemical /"adenosine"/ induce disease /"neurological and cardiovascular toxicity"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"indocyanine green"/ induces disease /"shock"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Survey of complications of /"indocyanine green"/ angiography in Japan. - Abstract: PURPOSE: We evaluated the safety of /"indocyanine green"/ for use in fundus angiography. METHODS: We sent a questionnaire concerning complications of /"indocyanine green"/ to 32 institutions in Japan, which were selected on the basis of the client list from the Topcon Company, which manufactures the /"indocyanine green"/ fundus camera. RESULTS: Ophthalmologists at 15 institutions responded, reporting a total of 3,774 /"indocyanine green"/ angiograms performed on 2,820 patients between June 1984 and September 1992. Before angiography, intradermal or intravenous /"indocyanine green"/ testing, or both was performed at 13 of 15 institutions. For three patients, the decision was made not to proceed with angiography after positive preangiographic testing. The dosage of /"indocyanine green"/ used for angiography varied from 25 to 75 mg, depending upon the institution. There were 13 cases of adverse reactions (0.34%), ten of which were mild reactions such as nausea, exanthema, urtication, itchiness, and urgency to defecate, and did not require treatment. Also recorded were one case of pain of the vein, which required treatment, and two cases of hypotension. The two hypotensive patients required treatment for /"shock"/. CONCLUSIONS: A comparison of frequency of adverse reactions to /"indocyanine green"/ with the previously reported frequency of such reactions to fluorescein sodium indicated that /"indocyanine green"/ is a safe as fluorescein for use in angiography. Question: Does chemical /"indocyanine green"/ induce disease /"shock"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"indocyanine green"/ induces disease /"pain"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Survey of complications of /"indocyanine green"/ angiography in Japan. - Abstract: PURPOSE: We evaluated the safety of /"indocyanine green"/ for use in fundus angiography. METHODS: We sent a questionnaire concerning complications of /"indocyanine green"/ to 32 institutions in Japan, which were selected on the basis of the client list from the Topcon Company, which manufactures the /"indocyanine green"/ fundus camera. RESULTS: Ophthalmologists at 15 institutions responded, reporting a total of 3,774 /"indocyanine green"/ angiograms performed on 2,820 patients between June 1984 and September 1992. Before angiography, intradermal or intravenous /"indocyanine green"/ testing, or both was performed at 13 of 15 institutions. For three patients, the decision was made not to proceed with angiography after positive preangiographic testing. The dosage of /"indocyanine green"/ used for angiography varied from 25 to 75 mg, depending upon the institution. There were 13 cases of adverse reactions (0.34%), ten of which were mild reactions such as nausea, exanthema, urtication, itchiness, and urgency to defecate, and did not require treatment. Also recorded were one case of /"pain"/ of the vein, which required treatment, and two cases of hypotension. The two hypotensive patients required treatment for shock. CONCLUSIONS: A comparison of frequency of adverse reactions to /"indocyanine green"/ with the previously reported frequency of such reactions to fluorescein sodium indicated that /"indocyanine green"/ is a safe as fluorescein for use in angiography. Question: Does chemical /"indocyanine green"/ induce disease /"pain"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"indocyanine green"/ induces disease /"hypotension"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Survey of complications of /"indocyanine green"/ angiography in Japan. - Abstract: PURPOSE: We evaluated the safety of /"indocyanine green"/ for use in fundus angiography. METHODS: We sent a questionnaire concerning complications of /"indocyanine green"/ to 32 institutions in Japan, which were selected on the basis of the client list from the Topcon Company, which manufactures the /"indocyanine green"/ fundus camera. RESULTS: Ophthalmologists at 15 institutions responded, reporting a total of 3,774 /"indocyanine green"/ angiograms performed on 2,820 patients between June 1984 and September 1992. Before angiography, intradermal or intravenous /"indocyanine green"/ testing, or both was performed at 13 of 15 institutions. For three patients, the decision was made not to proceed with angiography after positive preangiographic testing. The dosage of /"indocyanine green"/ used for angiography varied from 25 to 75 mg, depending upon the institution. There were 13 cases of adverse reactions (0.34%), ten of which were mild reactions such as nausea, exanthema, urtication, itchiness, and urgency to defecate, and did not require treatment. Also recorded were one case of pain of the vein, which required treatment, and two cases of /"hypotension"/. The two /"hypotensive"/ patients required treatment for shock. CONCLUSIONS: A comparison of frequency of adverse reactions to /"indocyanine green"/ with the previously reported frequency of such reactions to fluorescein sodium indicated that /"indocyanine green"/ is a safe as fluorescein for use in angiography. Question: Does chemical /"indocyanine green"/ induce disease /"hypotension"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"indocyanine green"/ induces disease /"itchiness"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Survey of complications of /"indocyanine green"/ angiography in Japan. - Abstract: PURPOSE: We evaluated the safety of /"indocyanine green"/ for use in fundus angiography. METHODS: We sent a questionnaire concerning complications of /"indocyanine green"/ to 32 institutions in Japan, which were selected on the basis of the client list from the Topcon Company, which manufactures the /"indocyanine green"/ fundus camera. RESULTS: Ophthalmologists at 15 institutions responded, reporting a total of 3,774 /"indocyanine green"/ angiograms performed on 2,820 patients between June 1984 and September 1992. Before angiography, intradermal or intravenous /"indocyanine green"/ testing, or both was performed at 13 of 15 institutions. For three patients, the decision was made not to proceed with angiography after positive preangiographic testing. The dosage of /"indocyanine green"/ used for angiography varied from 25 to 75 mg, depending upon the institution. There were 13 cases of adverse reactions (0.34%), ten of which were mild reactions such as nausea, exanthema, urtication, /"itchiness"/, and urgency to defecate, and did not require treatment. Also recorded were one case of pain of the vein, which required treatment, and two cases of hypotension. The two hypotensive patients required treatment for shock. CONCLUSIONS: A comparison of frequency of adverse reactions to /"indocyanine green"/ with the previously reported frequency of such reactions to fluorescein sodium indicated that /"indocyanine green"/ is a safe as fluorescein for use in angiography. Question: Does chemical /"indocyanine green"/ induce disease /"itchiness"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"indocyanine green"/ induces disease /"nausea"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Survey of complications of /"indocyanine green"/ angiography in Japan. - Abstract: PURPOSE: We evaluated the safety of /"indocyanine green"/ for use in fundus angiography. METHODS: We sent a questionnaire concerning complications of /"indocyanine green"/ to 32 institutions in Japan, which were selected on the basis of the client list from the Topcon Company, which manufactures the /"indocyanine green"/ fundus camera. RESULTS: Ophthalmologists at 15 institutions responded, reporting a total of 3,774 /"indocyanine green"/ angiograms performed on 2,820 patients between June 1984 and September 1992. Before angiography, intradermal or intravenous /"indocyanine green"/ testing, or both was performed at 13 of 15 institutions. For three patients, the decision was made not to proceed with angiography after positive preangiographic testing. The dosage of /"indocyanine green"/ used for angiography varied from 25 to 75 mg, depending upon the institution. There were 13 cases of adverse reactions (0.34%), ten of which were mild reactions such as /"nausea"/, exanthema, urtication, itchiness, and urgency to defecate, and did not require treatment. Also recorded were one case of pain of the vein, which required treatment, and two cases of hypotension. The two hypotensive patients required treatment for shock. CONCLUSIONS: A comparison of frequency of adverse reactions to /"indocyanine green"/ with the previously reported frequency of such reactions to fluorescein sodium indicated that /"indocyanine green"/ is a safe as fluorescein for use in angiography. Question: Does chemical /"indocyanine green"/ induce disease /"nausea"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"indocyanine green"/ induces disease /"exanthema"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Survey of complications of /"indocyanine green"/ angiography in Japan. - Abstract: PURPOSE: We evaluated the safety of /"indocyanine green"/ for use in fundus angiography. METHODS: We sent a questionnaire concerning complications of /"indocyanine green"/ to 32 institutions in Japan, which were selected on the basis of the client list from the Topcon Company, which manufactures the /"indocyanine green"/ fundus camera. RESULTS: Ophthalmologists at 15 institutions responded, reporting a total of 3,774 /"indocyanine green"/ angiograms performed on 2,820 patients between June 1984 and September 1992. Before angiography, intradermal or intravenous /"indocyanine green"/ testing, or both was performed at 13 of 15 institutions. For three patients, the decision was made not to proceed with angiography after positive preangiographic testing. The dosage of /"indocyanine green"/ used for angiography varied from 25 to 75 mg, depending upon the institution. There were 13 cases of adverse reactions (0.34%), ten of which were mild reactions such as nausea, /"exanthema"/, urtication, itchiness, and urgency to defecate, and did not require treatment. Also recorded were one case of pain of the vein, which required treatment, and two cases of hypotension. The two hypotensive patients required treatment for shock. CONCLUSIONS: A comparison of frequency of adverse reactions to /"indocyanine green"/ with the previously reported frequency of such reactions to fluorescein sodium indicated that /"indocyanine green"/ is a safe as fluorescein for use in angiography. Question: Does chemical /"indocyanine green"/ induce disease /"exanthema"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"indocyanine green"/ induces disease /"urtication"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Survey of complications of /"indocyanine green"/ angiography in Japan. - Abstract: PURPOSE: We evaluated the safety of /"indocyanine green"/ for use in fundus angiography. METHODS: We sent a questionnaire concerning complications of /"indocyanine green"/ to 32 institutions in Japan, which were selected on the basis of the client list from the Topcon Company, which manufactures the /"indocyanine green"/ fundus camera. RESULTS: Ophthalmologists at 15 institutions responded, reporting a total of 3,774 /"indocyanine green"/ angiograms performed on 2,820 patients between June 1984 and September 1992. Before angiography, intradermal or intravenous /"indocyanine green"/ testing, or both was performed at 13 of 15 institutions. For three patients, the decision was made not to proceed with angiography after positive preangiographic testing. The dosage of /"indocyanine green"/ used for angiography varied from 25 to 75 mg, depending upon the institution. There were 13 cases of adverse reactions (0.34%), ten of which were mild reactions such as nausea, exanthema, /"urtication"/, itchiness, and urgency to defecate, and did not require treatment. Also recorded were one case of pain of the vein, which required treatment, and two cases of hypotension. The two hypotensive patients required treatment for shock. CONCLUSIONS: A comparison of frequency of adverse reactions to /"indocyanine green"/ with the previously reported frequency of such reactions to fluorescein sodium indicated that /"indocyanine green"/ is a safe as fluorescein for use in angiography. Question: Does chemical /"indocyanine green"/ induce disease /"urtication"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"fluorescein sodium"/ induces disease /"nausea"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Survey of complications of indocyanine green angiography in Japan. - Abstract: PURPOSE: We evaluated the safety of indocyanine green for use in fundus angiography. METHODS: We sent a questionnaire concerning complications of indocyanine green to 32 institutions in Japan, which were selected on the basis of the client list from the Topcon Company, which manufactures the indocyanine green fundus camera. RESULTS: Ophthalmologists at 15 institutions responded, reporting a total of 3,774 indocyanine green angiograms performed on 2,820 patients between June 1984 and September 1992. Before angiography, intradermal or intravenous indocyanine green testing, or both was performed at 13 of 15 institutions. For three patients, the decision was made not to proceed with angiography after positive preangiographic testing. The dosage of indocyanine green used for angiography varied from 25 to 75 mg, depending upon the institution. There were 13 cases of adverse reactions (0.34%), ten of which were mild reactions such as /"nausea"/, exanthema, urtication, itchiness, and urgency to defecate, and did not require treatment. Also recorded were one case of pain of the vein, which required treatment, and two cases of hypotension. The two hypotensive patients required treatment for shock. CONCLUSIONS: A comparison of frequency of adverse reactions to indocyanine green with the previously reported frequency of such reactions to /"fluorescein sodium"/ indicated that indocyanine green is a safe as /"fluorescein"/ for use in angiography. Question: Does chemical /"fluorescein sodium"/ induce disease /"nausea"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"fluorescein sodium"/ induces disease /"hypotension"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Survey of complications of indocyanine green angiography in Japan. - Abstract: PURPOSE: We evaluated the safety of indocyanine green for use in fundus angiography. METHODS: We sent a questionnaire concerning complications of indocyanine green to 32 institutions in Japan, which were selected on the basis of the client list from the Topcon Company, which manufactures the indocyanine green fundus camera. RESULTS: Ophthalmologists at 15 institutions responded, reporting a total of 3,774 indocyanine green angiograms performed on 2,820 patients between June 1984 and September 1992. Before angiography, intradermal or intravenous indocyanine green testing, or both was performed at 13 of 15 institutions. For three patients, the decision was made not to proceed with angiography after positive preangiographic testing. The dosage of indocyanine green used for angiography varied from 25 to 75 mg, depending upon the institution. There were 13 cases of adverse reactions (0.34%), ten of which were mild reactions such as nausea, exanthema, urtication, itchiness, and urgency to defecate, and did not require treatment. Also recorded were one case of pain of the vein, which required treatment, and two cases of /"hypotension"/. The two /"hypotensive"/ patients required treatment for shock. CONCLUSIONS: A comparison of frequency of adverse reactions to indocyanine green with the previously reported frequency of such reactions to /"fluorescein sodium"/ indicated that indocyanine green is a safe as /"fluorescein"/ for use in angiography. Question: Does chemical /"fluorescein sodium"/ induce disease /"hypotension"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"fluorescein sodium"/ induces disease /"pain"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Survey of complications of indocyanine green angiography in Japan. - Abstract: PURPOSE: We evaluated the safety of indocyanine green for use in fundus angiography. METHODS: We sent a questionnaire concerning complications of indocyanine green to 32 institutions in Japan, which were selected on the basis of the client list from the Topcon Company, which manufactures the indocyanine green fundus camera. RESULTS: Ophthalmologists at 15 institutions responded, reporting a total of 3,774 indocyanine green angiograms performed on 2,820 patients between June 1984 and September 1992. Before angiography, intradermal or intravenous indocyanine green testing, or both was performed at 13 of 15 institutions. For three patients, the decision was made not to proceed with angiography after positive preangiographic testing. The dosage of indocyanine green used for angiography varied from 25 to 75 mg, depending upon the institution. There were 13 cases of adverse reactions (0.34%), ten of which were mild reactions such as nausea, exanthema, urtication, itchiness, and urgency to defecate, and did not require treatment. Also recorded were one case of /"pain"/ of the vein, which required treatment, and two cases of hypotension. The two hypotensive patients required treatment for shock. CONCLUSIONS: A comparison of frequency of adverse reactions to indocyanine green with the previously reported frequency of such reactions to /"fluorescein sodium"/ indicated that indocyanine green is a safe as /"fluorescein"/ for use in angiography. Question: Does chemical /"fluorescein sodium"/ induce disease /"pain"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"fluorescein sodium"/ induces disease /"urtication"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Survey of complications of indocyanine green angiography in Japan. - Abstract: PURPOSE: We evaluated the safety of indocyanine green for use in fundus angiography. METHODS: We sent a questionnaire concerning complications of indocyanine green to 32 institutions in Japan, which were selected on the basis of the client list from the Topcon Company, which manufactures the indocyanine green fundus camera. RESULTS: Ophthalmologists at 15 institutions responded, reporting a total of 3,774 indocyanine green angiograms performed on 2,820 patients between June 1984 and September 1992. Before angiography, intradermal or intravenous indocyanine green testing, or both was performed at 13 of 15 institutions. For three patients, the decision was made not to proceed with angiography after positive preangiographic testing. The dosage of indocyanine green used for angiography varied from 25 to 75 mg, depending upon the institution. There were 13 cases of adverse reactions (0.34%), ten of which were mild reactions such as nausea, exanthema, /"urtication"/, itchiness, and urgency to defecate, and did not require treatment. Also recorded were one case of pain of the vein, which required treatment, and two cases of hypotension. The two hypotensive patients required treatment for shock. CONCLUSIONS: A comparison of frequency of adverse reactions to indocyanine green with the previously reported frequency of such reactions to /"fluorescein sodium"/ indicated that indocyanine green is a safe as /"fluorescein"/ for use in angiography. Question: Does chemical /"fluorescein sodium"/ induce disease /"urtication"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"fluorescein sodium"/ induces disease /"shock"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Survey of complications of indocyanine green angiography in Japan. - Abstract: PURPOSE: We evaluated the safety of indocyanine green for use in fundus angiography. METHODS: We sent a questionnaire concerning complications of indocyanine green to 32 institutions in Japan, which were selected on the basis of the client list from the Topcon Company, which manufactures the indocyanine green fundus camera. RESULTS: Ophthalmologists at 15 institutions responded, reporting a total of 3,774 indocyanine green angiograms performed on 2,820 patients between June 1984 and September 1992. Before angiography, intradermal or intravenous indocyanine green testing, or both was performed at 13 of 15 institutions. For three patients, the decision was made not to proceed with angiography after positive preangiographic testing. The dosage of indocyanine green used for angiography varied from 25 to 75 mg, depending upon the institution. There were 13 cases of adverse reactions (0.34%), ten of which were mild reactions such as nausea, exanthema, urtication, itchiness, and urgency to defecate, and did not require treatment. Also recorded were one case of pain of the vein, which required treatment, and two cases of hypotension. The two hypotensive patients required treatment for /"shock"/. CONCLUSIONS: A comparison of frequency of adverse reactions to indocyanine green with the previously reported frequency of such reactions to /"fluorescein sodium"/ indicated that indocyanine green is a safe as /"fluorescein"/ for use in angiography. Question: Does chemical /"fluorescein sodium"/ induce disease /"shock"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"fluorescein sodium"/ induces disease /"itchiness"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Survey of complications of indocyanine green angiography in Japan. - Abstract: PURPOSE: We evaluated the safety of indocyanine green for use in fundus angiography. METHODS: We sent a questionnaire concerning complications of indocyanine green to 32 institutions in Japan, which were selected on the basis of the client list from the Topcon Company, which manufactures the indocyanine green fundus camera. RESULTS: Ophthalmologists at 15 institutions responded, reporting a total of 3,774 indocyanine green angiograms performed on 2,820 patients between June 1984 and September 1992. Before angiography, intradermal or intravenous indocyanine green testing, or both was performed at 13 of 15 institutions. For three patients, the decision was made not to proceed with angiography after positive preangiographic testing. The dosage of indocyanine green used for angiography varied from 25 to 75 mg, depending upon the institution. There were 13 cases of adverse reactions (0.34%), ten of which were mild reactions such as nausea, exanthema, urtication, /"itchiness"/, and urgency to defecate, and did not require treatment. Also recorded were one case of pain of the vein, which required treatment, and two cases of hypotension. The two hypotensive patients required treatment for shock. CONCLUSIONS: A comparison of frequency of adverse reactions to indocyanine green with the previously reported frequency of such reactions to /"fluorescein sodium"/ indicated that indocyanine green is a safe as /"fluorescein"/ for use in angiography. Question: Does chemical /"fluorescein sodium"/ induce disease /"itchiness"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"fluorescein sodium"/ induces disease /"exanthema"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Survey of complications of indocyanine green angiography in Japan. - Abstract: PURPOSE: We evaluated the safety of indocyanine green for use in fundus angiography. METHODS: We sent a questionnaire concerning complications of indocyanine green to 32 institutions in Japan, which were selected on the basis of the client list from the Topcon Company, which manufactures the indocyanine green fundus camera. RESULTS: Ophthalmologists at 15 institutions responded, reporting a total of 3,774 indocyanine green angiograms performed on 2,820 patients between June 1984 and September 1992. Before angiography, intradermal or intravenous indocyanine green testing, or both was performed at 13 of 15 institutions. For three patients, the decision was made not to proceed with angiography after positive preangiographic testing. The dosage of indocyanine green used for angiography varied from 25 to 75 mg, depending upon the institution. There were 13 cases of adverse reactions (0.34%), ten of which were mild reactions such as nausea, /"exanthema"/, urtication, itchiness, and urgency to defecate, and did not require treatment. Also recorded were one case of pain of the vein, which required treatment, and two cases of hypotension. The two hypotensive patients required treatment for shock. CONCLUSIONS: A comparison of frequency of adverse reactions to indocyanine green with the previously reported frequency of such reactions to /"fluorescein sodium"/ indicated that indocyanine green is a safe as /"fluorescein"/ for use in angiography. Question: Does chemical /"fluorescein sodium"/ induce disease /"exanthema"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"streptozotocin"/ induces disease /"diabetic neuropathy"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and /"streptozotocin"/ induced hyperalgesia in chemotherapy and /"diabetic neuropathy"/ rat model. - Abstract: PURPOSE: The influence of an irreversible inhibitor of constitutive NO synthase (L-NOArg; 1.0 mg/kg ip), a relatively selective inhibitor of inducible NO synthase (L-NIL; 1.0 mg/kg ip) and a relatively specific inhibitor of neuronal NO synthase (7-NI; 0.1 mg/kg ip), on antihyperalgesic action of selective antagonists of B2 and B1 receptors: D-Arg-[Hyp3,Thi5,D-Tic7,Oic8] bradykinin (HOE 140; 70 nmol/kg ip) or des Arg10 HOE 140 (70 nmol/kg ip) respectively, in model of /"diabetic (streptozotocin-induced)"/ and toxic (vincristine-induced) /"diabetic (streptozotocin-induced)"/ was investigated. METHODS: The changes in pain thresholds were determined using mechanical stimuli--the modification of the classic paw withdrawal test described by Randall-Selitto. RESULTS: The results of this paper confirm that inhibition of bradykinin receptors and inducible NO synthase but not neuronal NO synthase activity reduces diabetic hyperalgesia. Pretreatment with L-NOArg and L-NIL but not 7-NI, significantly increases antihyperalgesic activity both HOE 140 and des Arg10 HOE 140. It was also shown that both products of inducible NO synthase and neuronal NO synthase activation as well as bradykinin are involved in hyperalgesia produced by vincristine. Moreover, L-NOArg and 7-NI but not L-NIL intensify antihyperalgesic activity of HOE 140 or des-Arg10HOE 140 in toxic neuropathy. CONCLUSIONS: Results of these studies suggest that B1 and B2 receptors are engaged in transmission of nociceptive stimuli in both /"diabetic"/ and toxic /"diabetic"/. In /"streptozotocin"/-induced hyperalgesia, inducible NO synthase participates in pronociceptive activity of bradykinin, whereas in vincristine-induced hyperalgesia bradykinin seemed to activate neuronal NO synthase pathway. Therefore, concomitant administration of small doses of bradykinin receptor antagonists and NO synthase inhibitors can be effective in alleviation of neuropathic pain, even in hospital care. Question: Does chemical /"streptozotocin"/ induce disease /"diabetic neuropathy"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"streptozotocin"/ induces disease /"diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and /"streptozotocin"/ induced hyperalgesia in chemotherapy and diabetic neuropathy rat model. - Abstract: PURPOSE: The influence of an irreversible inhibitor of constitutive NO synthase (L-NOArg; 1.0 mg/kg ip), a relatively selective inhibitor of inducible NO synthase (L-NIL; 1.0 mg/kg ip) and a relatively specific inhibitor of neuronal NO synthase (7-NI; 0.1 mg/kg ip), on antihyperalgesic action of selective antagonists of B2 and B1 receptors: D-Arg-[Hyp3,Thi5,D-Tic7,Oic8] bradykinin (HOE 140; 70 nmol/kg ip) or des Arg10 HOE 140 (70 nmol/kg ip) respectively, in model of /"diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy"/ was investigated. METHODS: The changes in pain thresholds were determined using mechanical stimuli--the modification of the classic paw withdrawal test described by Randall-Selitto. RESULTS: The results of this paper confirm that inhibition of bradykinin receptors and inducible NO synthase but not neuronal NO synthase activity reduces diabetic hyperalgesia. Pretreatment with L-NOArg and L-NIL but not 7-NI, significantly increases antihyperalgesic activity both HOE 140 and des Arg10 HOE 140. It was also shown that both products of inducible NO synthase and neuronal NO synthase activation as well as bradykinin are involved in hyperalgesia produced by vincristine. Moreover, L-NOArg and 7-NI but not L-NIL intensify antihyperalgesic activity of HOE 140 or des-Arg10HOE 140 in toxic neuropathy. CONCLUSIONS: Results of these studies suggest that B1 and B2 receptors are engaged in transmission of nociceptive stimuli in both /"diabetic and toxic neuropathy"/. In /"streptozotocin"/-induced hyperalgesia, inducible NO synthase participates in pronociceptive activity of bradykinin, whereas in vincristine-induced hyperalgesia bradykinin seemed to activate neuronal NO synthase pathway. Therefore, concomitant administration of small doses of bradykinin receptor antagonists and NO synthase inhibitors can be effective in alleviation of neuropathic pain, even in hospital care. Question: Does chemical /"streptozotocin"/ induce disease /"diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"streptozotocin"/ induces disease /"hyperalgesia"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and /"streptozotocin"/ induced /"hyperalgesia"/ in chemotherapy and diabetic neuropathy rat model. - Abstract: PURPOSE: The influence of an irreversible inhibitor of constitutive NO synthase (L-NOArg; 1.0 mg/kg ip), a relatively selective inhibitor of inducible NO synthase (L-NIL; 1.0 mg/kg ip) and a relatively specific inhibitor of neuronal NO synthase (7-NI; 0.1 mg/kg ip), on antihyperalgesic action of selective antagonists of B2 and B1 receptors: D-Arg-[Hyp3,Thi5,D-Tic7,Oic8] bradykinin (HOE 140; 70 nmol/kg ip) or des Arg10 HOE 140 (70 nmol/kg ip) respectively, in model of diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy was investigated. METHODS: The changes in pain thresholds were determined using mechanical stimuli--the modification of the classic paw withdrawal test described by Randall-Selitto. RESULTS: The results of this paper confirm that inhibition of bradykinin receptors and inducible NO synthase but not neuronal NO synthase activity reduces /"diabetic hyperalgesia"/. Pretreatment with L-NOArg and L-NIL but not 7-NI, significantly increases antihyperalgesic activity both HOE 140 and des Arg10 HOE 140. It was also shown that both products of inducible NO synthase and neuronal NO synthase activation as well as bradykinin are involved in /"hyperalgesia"/ produced by vincristine. Moreover, L-NOArg and 7-NI but not L-NIL intensify antihyperalgesic activity of HOE 140 or des-Arg10HOE 140 in toxic neuropathy. CONCLUSIONS: Results of these studies suggest that B1 and B2 receptors are engaged in transmission of nociceptive stimuli in both diabetic and toxic neuropathy. In /"streptozotocin"/-induced /"hyperalgesia"/, inducible NO synthase participates in pronociceptive activity of bradykinin, whereas in vincristine-induced /"hyperalgesia"/ bradykinin seemed to activate neuronal NO synthase pathway. Therefore, concomitant administration of small doses of bradykinin receptor antagonists and NO synthase inhibitors can be effective in alleviation of neuropathic pain, even in hospital care. Question: Does chemical /"streptozotocin"/ induce disease /"hyperalgesia"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"vincristine"/ induces disease /"diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Bradykinin receptors antagonists and nitric oxide synthase inhibitors in /"vincristine"/ and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model. - Abstract: PURPOSE: The influence of an irreversible inhibitor of constitutive NO synthase (L-NOArg; 1.0 mg/kg ip), a relatively selective inhibitor of inducible NO synthase (L-NIL; 1.0 mg/kg ip) and a relatively specific inhibitor of neuronal NO synthase (7-NI; 0.1 mg/kg ip), on antihyperalgesic action of selective antagonists of B2 and B1 receptors: D-Arg-[Hyp3,Thi5,D-Tic7,Oic8] bradykinin (HOE 140; 70 nmol/kg ip) or des Arg10 HOE 140 (70 nmol/kg ip) respectively, in model of /"diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy"/ was investigated. METHODS: The changes in pain thresholds were determined using mechanical stimuli--the modification of the classic paw withdrawal test described by Randall-Selitto. RESULTS: The results of this paper confirm that inhibition of bradykinin receptors and inducible NO synthase but not neuronal NO synthase activity reduces diabetic hyperalgesia. Pretreatment with L-NOArg and L-NIL but not 7-NI, significantly increases antihyperalgesic activity both HOE 140 and des Arg10 HOE 140. It was also shown that both products of inducible NO synthase and neuronal NO synthase activation as well as bradykinin are involved in hyperalgesia produced by /"vincristine"/. Moreover, L-NOArg and 7-NI but not L-NIL intensify antihyperalgesic activity of HOE 140 or des-Arg10HOE 140 in toxic neuropathy. CONCLUSIONS: Results of these studies suggest that B1 and B2 receptors are engaged in transmission of nociceptive stimuli in both /"diabetic and toxic neuropathy"/. In streptozotocin-induced hyperalgesia, inducible NO synthase participates in pronociceptive activity of bradykinin, whereas in /"vincristine"/-induced hyperalgesia bradykinin seemed to activate neuronal NO synthase pathway. Therefore, concomitant administration of small doses of bradykinin receptor antagonists and NO synthase inhibitors can be effective in alleviation of neuropathic pain, even in hospital care. Question: Does chemical /"vincristine"/ induce disease /"diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"vincristine"/ induces disease /"toxic (vincristine-induced) neuropathy"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Bradykinin receptors antagonists and nitric oxide synthase inhibitors in /"vincristine"/ and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model. - Abstract: PURPOSE: The influence of an irreversible inhibitor of constitutive NO synthase (L-NOArg; 1.0 mg/kg ip), a relatively selective inhibitor of inducible NO synthase (L-NIL; 1.0 mg/kg ip) and a relatively specific inhibitor of neuronal NO synthase (7-NI; 0.1 mg/kg ip), on antihyperalgesic action of selective antagonists of B2 and B1 receptors: D-Arg-[Hyp3,Thi5,D-Tic7,Oic8] bradykinin (HOE 140; 70 nmol/kg ip) or des Arg10 HOE 140 (70 nmol/kg ip) respectively, in model of diabetic (streptozotocin-induced) and /"toxic (vincristine-induced) neuropathy"/ was investigated. METHODS: The changes in pain thresholds were determined using mechanical stimuli--the modification of the classic paw withdrawal test described by Randall-Selitto. RESULTS: The results of this paper confirm that inhibition of bradykinin receptors and inducible NO synthase but not neuronal NO synthase activity reduces diabetic hyperalgesia. Pretreatment with L-NOArg and L-NIL but not 7-NI, significantly increases antihyperalgesic activity both HOE 140 and des Arg10 HOE 140. It was also shown that both products of inducible NO synthase and neuronal NO synthase activation as well as bradykinin are involved in hyperalgesia produced by /"vincristine"/. Moreover, L-NOArg and 7-NI but not L-NIL intensify antihyperalgesic activity of HOE 140 or des-Arg10HOE 140 in /"toxic neuropathy"/. CONCLUSIONS: Results of these studies suggest that B1 and B2 receptors are engaged in transmission of nociceptive stimuli in both diabetic and /"toxic neuropathy"/. In streptozotocin-induced hyperalgesia, inducible NO synthase participates in pronociceptive activity of bradykinin, whereas in /"vincristine"/-induced hyperalgesia bradykinin seemed to activate neuronal NO synthase pathway. Therefore, concomitant administration of small doses of bradykinin receptor antagonists and NO synthase inhibitors can be effective in alleviation of neuropathic pain, even in hospital care. Question: Does chemical /"vincristine"/ induce disease /"toxic (vincristine-induced) neuropathy"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"vincristine"/ induces disease /"hyperalgesia"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Bradykinin receptors antagonists and nitric oxide synthase inhibitors in /"vincristine"/ and streptozotocin induced /"hyperalgesia"/ in chemotherapy and diabetic neuropathy rat model. - Abstract: PURPOSE: The influence of an irreversible inhibitor of constitutive NO synthase (L-NOArg; 1.0 mg/kg ip), a relatively selective inhibitor of inducible NO synthase (L-NIL; 1.0 mg/kg ip) and a relatively specific inhibitor of neuronal NO synthase (7-NI; 0.1 mg/kg ip), on antihyperalgesic action of selective antagonists of B2 and B1 receptors: D-Arg-[Hyp3,Thi5,D-Tic7,Oic8] bradykinin (HOE 140; 70 nmol/kg ip) or des Arg10 HOE 140 (70 nmol/kg ip) respectively, in model of diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy was investigated. METHODS: The changes in pain thresholds were determined using mechanical stimuli--the modification of the classic paw withdrawal test described by Randall-Selitto. RESULTS: The results of this paper confirm that inhibition of bradykinin receptors and inducible NO synthase but not neuronal NO synthase activity reduces /"diabetic hyperalgesia"/. Pretreatment with L-NOArg and L-NIL but not 7-NI, significantly increases antihyperalgesic activity both HOE 140 and des Arg10 HOE 140. It was also shown that both products of inducible NO synthase and neuronal NO synthase activation as well as bradykinin are involved in /"hyperalgesia"/ produced by /"vincristine"/. Moreover, L-NOArg and 7-NI but not L-NIL intensify antihyperalgesic activity of HOE 140 or des-Arg10HOE 140 in toxic neuropathy. CONCLUSIONS: Results of these studies suggest that B1 and B2 receptors are engaged in transmission of nociceptive stimuli in both diabetic and toxic neuropathy. In streptozotocin-induced /"hyperalgesia"/, inducible NO synthase participates in pronociceptive activity of bradykinin, whereas in /"vincristine"/-induced /"hyperalgesia"/ bradykinin seemed to activate neuronal NO synthase pathway. Therefore, concomitant administration of small doses of bradykinin receptor antagonists and NO synthase inhibitors can be effective in alleviation of neuropathic pain, even in hospital care. Question: Does chemical /"vincristine"/ induce disease /"hyperalgesia"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"nitric oxide"/ induces disease /"pain"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Bradykinin receptors antagonists and /"nitric oxide"/ synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model. - Abstract: PURPOSE: The influence of an irreversible inhibitor of constitutive /"NO"/ synthase (L-NOArg; 1.0 mg/kg ip), a relatively selective inhibitor of inducible /"NO"/ synthase (L-NIL; 1.0 mg/kg ip) and a relatively specific inhibitor of neuronal /"NO"/ synthase (7-NI; 0.1 mg/kg ip), on antihyperalgesic action of selective antagonists of B2 and B1 receptors: D-Arg-[Hyp3,Thi5,D-Tic7,Oic8] bradykinin (HOE 140; 70 nmol/kg ip) or des Arg10 HOE 140 (70 nmol/kg ip) respectively, in model of diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy was investigated. METHODS: The changes in /"pain"/ thresholds were determined using mechanical stimuli--the modification of the classic paw withdrawal test described by Randall-Selitto. RESULTS: The results of this paper confirm that inhibition of bradykinin receptors and inducible /"NO"/ synthase but not neuronal /"NO"/ synthase activity reduces diabetic hyperalgesia. Pretreatment with L-NOArg and L-NIL but not 7-NI, significantly increases antihyperalgesic activity both HOE 140 and des Arg10 HOE 140. It was also shown that both products of inducible /"NO"/ synthase and neuronal /"NO"/ synthase activation as well as bradykinin are involved in hyperalgesia produced by vincristine. Moreover, L-NOArg and 7-NI but not L-NIL intensify antihyperalgesic activity of HOE 140 or des-Arg10HOE 140 in toxic neuropathy. CONCLUSIONS: Results of these studies suggest that B1 and B2 receptors are engaged in transmission of nociceptive stimuli in both diabetic and toxic neuropathy. In streptozotocin-induced hyperalgesia, inducible /"NO"/ synthase participates in pronociceptive activity of bradykinin, whereas in vincristine-induced hyperalgesia bradykinin seemed to activate neuronal /"NO"/ synthase pathway. Therefore, concomitant administration of small doses of bradykinin receptor antagonists and /"NO"/ synthase inhibitors can be effective in alleviation of neuropathic pain, even in hospital care. Question: Does chemical /"nitric oxide"/ induce disease /"pain"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"des Arg10 HOE 140"/ induces disease /"diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model. - Abstract: PURPOSE: The influence of an irreversible inhibitor of constitutive NO synthase (L-NOArg; 1.0 mg/kg ip), a relatively selective inhibitor of inducible NO synthase (L-NIL; 1.0 mg/kg ip) and a relatively specific inhibitor of neuronal NO synthase (7-NI; 0.1 mg/kg ip), on antihyperalgesic action of selective antagonists of B2 and B1 receptors: D-Arg-[Hyp3,Thi5,D-Tic7,Oic8] bradykinin (HOE 140; 70 nmol/kg ip) or /"des Arg10 HOE 140"/ (70 nmol/kg ip) respectively, in model of /"diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy"/ was investigated. METHODS: The changes in pain thresholds were determined using mechanical stimuli--the modification of the classic paw withdrawal test described by Randall-Selitto. RESULTS: The results of this paper confirm that inhibition of bradykinin receptors and inducible NO synthase but not neuronal NO synthase activity reduces diabetic hyperalgesia. Pretreatment with L-NOArg and L-NIL but not 7-NI, significantly increases antihyperalgesic activity both HOE 140 and /"des Arg10 HOE 140"/. It was also shown that both products of inducible NO synthase and neuronal NO synthase activation as well as bradykinin are involved in hyperalgesia produced by vincristine. Moreover, L-NOArg and 7-NI but not L-NIL intensify antihyperalgesic activity of HOE 140 or /"des-Arg10HOE 140"/ in toxic neuropathy. CONCLUSIONS: Results of these studies suggest that B1 and B2 receptors are engaged in transmission of nociceptive stimuli in both /"diabetic and toxic neuropathy"/. In streptozotocin-induced hyperalgesia, inducible NO synthase participates in pronociceptive activity of bradykinin, whereas in vincristine-induced hyperalgesia bradykinin seemed to activate neuronal NO synthase pathway. Therefore, concomitant administration of small doses of bradykinin receptor antagonists and NO synthase inhibitors can be effective in alleviation of neuropathic pain, even in hospital care. Question: Does chemical /"des Arg10 HOE 140"/ induce disease /"diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"nitric oxide"/ induces disease /"diabetic neuropathy"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Bradykinin receptors antagonists and /"nitric oxide"/ synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and /"diabetic neuropathy"/ rat model. - Abstract: PURPOSE: The influence of an irreversible inhibitor of constitutive /"NO"/ synthase (L-NOArg; 1.0 mg/kg ip), a relatively selective inhibitor of inducible /"NO"/ synthase (L-NIL; 1.0 mg/kg ip) and a relatively specific inhibitor of neuronal /"NO"/ synthase (7-NI; 0.1 mg/kg ip), on antihyperalgesic action of selective antagonists of B2 and B1 receptors: D-Arg-[Hyp3,Thi5,D-Tic7,Oic8] bradykinin (HOE 140; 70 nmol/kg ip) or des Arg10 HOE 140 (70 nmol/kg ip) respectively, in model of /"diabetic (streptozotocin-induced)"/ and toxic (vincristine-induced) /"diabetic (streptozotocin-induced)"/ was investigated. METHODS: The changes in pain thresholds were determined using mechanical stimuli--the modification of the classic paw withdrawal test described by Randall-Selitto. RESULTS: The results of this paper confirm that inhibition of bradykinin receptors and inducible /"NO"/ synthase but not neuronal /"NO"/ synthase activity reduces diabetic hyperalgesia. Pretreatment with L-NOArg and L-NIL but not 7-NI, significantly increases antihyperalgesic activity both HOE 140 and des Arg10 HOE 140. It was also shown that both products of inducible /"NO"/ synthase and neuronal /"NO"/ synthase activation as well as bradykinin are involved in hyperalgesia produced by vincristine. Moreover, L-NOArg and 7-NI but not L-NIL intensify antihyperalgesic activity of HOE 140 or des-Arg10HOE 140 in toxic neuropathy. CONCLUSIONS: Results of these studies suggest that B1 and B2 receptors are engaged in transmission of nociceptive stimuli in both /"diabetic"/ and toxic /"diabetic"/. In streptozotocin-induced hyperalgesia, inducible /"NO"/ synthase participates in pronociceptive activity of bradykinin, whereas in vincristine-induced hyperalgesia bradykinin seemed to activate neuronal /"NO"/ synthase pathway. Therefore, concomitant administration of small doses of bradykinin receptor antagonists and /"NO"/ synthase inhibitors can be effective in alleviation of neuropathic pain, even in hospital care. Question: Does chemical /"nitric oxide"/ induce disease /"diabetic neuropathy"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"HOE 140"/ induces disease /"hyperalgesia"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced /"hyperalgesia"/ in chemotherapy and diabetic neuropathy rat model. - Abstract: PURPOSE: The influence of an irreversible inhibitor of constitutive NO synthase (L-NOArg; 1.0 mg/kg ip), a relatively selective inhibitor of inducible NO synthase (L-NIL; 1.0 mg/kg ip) and a relatively specific inhibitor of neuronal NO synthase (7-NI; 0.1 mg/kg ip), on antihyperalgesic action of selective antagonists of B2 and B1 receptors: D-Arg-[Hyp3,Thi5,D-Tic7,Oic8] bradykinin (/"HOE 140"/; 70 nmol/kg ip) or des Arg10 HOE 140 (70 nmol/kg ip) respectively, in model of diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy was investigated. METHODS: The changes in pain thresholds were determined using mechanical stimuli--the modification of the classic paw withdrawal test described by Randall-Selitto. RESULTS: The results of this paper confirm that inhibition of bradykinin receptors and inducible NO synthase but not neuronal NO synthase activity reduces /"diabetic hyperalgesia"/. Pretreatment with L-NOArg and L-NIL but not 7-NI, significantly increases antihyperalgesic activity both /"HOE 140"/ and des Arg10 HOE 140. It was also shown that both products of inducible NO synthase and neuronal NO synthase activation as well as bradykinin are involved in /"hyperalgesia"/ produced by vincristine. Moreover, L-NOArg and 7-NI but not L-NIL intensify antihyperalgesic activity of /"HOE 140"/ or des-Arg10HOE 140 in toxic neuropathy. CONCLUSIONS: Results of these studies suggest that B1 and B2 receptors are engaged in transmission of nociceptive stimuli in both diabetic and toxic neuropathy. In streptozotocin-induced /"hyperalgesia"/, inducible NO synthase participates in pronociceptive activity of bradykinin, whereas in vincristine-induced /"hyperalgesia"/ bradykinin seemed to activate neuronal NO synthase pathway. Therefore, concomitant administration of small doses of bradykinin receptor antagonists and NO synthase inhibitors can be effective in alleviation of neuropathic pain, even in hospital care. Question: Does chemical /"HOE 140"/ induce disease /"hyperalgesia"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"HOE 140"/ induces disease /"pain"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model. - Abstract: PURPOSE: The influence of an irreversible inhibitor of constitutive NO synthase (L-NOArg; 1.0 mg/kg ip), a relatively selective inhibitor of inducible NO synthase (L-NIL; 1.0 mg/kg ip) and a relatively specific inhibitor of neuronal NO synthase (7-NI; 0.1 mg/kg ip), on antihyperalgesic action of selective antagonists of B2 and B1 receptors: D-Arg-[Hyp3,Thi5,D-Tic7,Oic8] bradykinin (/"HOE 140"/; 70 nmol/kg ip) or des Arg10 HOE 140 (70 nmol/kg ip) respectively, in model of diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy was investigated. METHODS: The changes in /"pain"/ thresholds were determined using mechanical stimuli--the modification of the classic paw withdrawal test described by Randall-Selitto. RESULTS: The results of this paper confirm that inhibition of bradykinin receptors and inducible NO synthase but not neuronal NO synthase activity reduces diabetic hyperalgesia. Pretreatment with L-NOArg and L-NIL but not 7-NI, significantly increases antihyperalgesic activity both /"HOE 140"/ and des Arg10 HOE 140. It was also shown that both products of inducible NO synthase and neuronal NO synthase activation as well as bradykinin are involved in hyperalgesia produced by vincristine. Moreover, L-NOArg and 7-NI but not L-NIL intensify antihyperalgesic activity of /"HOE 140"/ or des-Arg10HOE 140 in toxic neuropathy. CONCLUSIONS: Results of these studies suggest that B1 and B2 receptors are engaged in transmission of nociceptive stimuli in both diabetic and toxic neuropathy. In streptozotocin-induced hyperalgesia, inducible NO synthase participates in pronociceptive activity of bradykinin, whereas in vincristine-induced hyperalgesia bradykinin seemed to activate neuronal NO synthase pathway. Therefore, concomitant administration of small doses of bradykinin receptor antagonists and NO synthase inhibitors can be effective in alleviation of neuropathic pain, even in hospital care. Question: Does chemical /"HOE 140"/ induce disease /"pain"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"HOE 140"/ induces disease /"toxic (vincristine-induced) neuropathy"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model. - Abstract: PURPOSE: The influence of an irreversible inhibitor of constitutive NO synthase (L-NOArg; 1.0 mg/kg ip), a relatively selective inhibitor of inducible NO synthase (L-NIL; 1.0 mg/kg ip) and a relatively specific inhibitor of neuronal NO synthase (7-NI; 0.1 mg/kg ip), on antihyperalgesic action of selective antagonists of B2 and B1 receptors: D-Arg-[Hyp3,Thi5,D-Tic7,Oic8] bradykinin (/"HOE 140"/; 70 nmol/kg ip) or des Arg10 HOE 140 (70 nmol/kg ip) respectively, in model of diabetic (streptozotocin-induced) and /"toxic (vincristine-induced) neuropathy"/ was investigated. METHODS: The changes in pain thresholds were determined using mechanical stimuli--the modification of the classic paw withdrawal test described by Randall-Selitto. RESULTS: The results of this paper confirm that inhibition of bradykinin receptors and inducible NO synthase but not neuronal NO synthase activity reduces diabetic hyperalgesia. Pretreatment with L-NOArg and L-NIL but not 7-NI, significantly increases antihyperalgesic activity both /"HOE 140"/ and des Arg10 HOE 140. It was also shown that both products of inducible NO synthase and neuronal NO synthase activation as well as bradykinin are involved in hyperalgesia produced by vincristine. Moreover, L-NOArg and 7-NI but not L-NIL intensify antihyperalgesic activity of /"HOE 140"/ or des-Arg10HOE 140 in /"toxic neuropathy"/. CONCLUSIONS: Results of these studies suggest that B1 and B2 receptors are engaged in transmission of nociceptive stimuli in both diabetic and /"toxic neuropathy"/. In streptozotocin-induced hyperalgesia, inducible NO synthase participates in pronociceptive activity of bradykinin, whereas in vincristine-induced hyperalgesia bradykinin seemed to activate neuronal NO synthase pathway. Therefore, concomitant administration of small doses of bradykinin receptor antagonists and NO synthase inhibitors can be effective in alleviation of neuropathic pain, even in hospital care. Question: Does chemical /"HOE 140"/ induce disease /"toxic (vincristine-induced) neuropathy"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"cyclophosphamide"/ induces disease /"congestive heart failure"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Cardiac toxicity observed in association with high-dose /"cyclophosphamide"/-based chemotherapy for metastatic breast cancer. - Abstract: INTRODUCTION: /"Cyclophosphamide"/ is an alkylating agent given frequently as a component of many conditioning regimens. In high doses, its nonhematological dose-limiting toxicity is cardiomyopathy. STUDY DESIGN: We combined paclitaxel, melphalan and high-dose /"cyclophosphamide"/, thiotepa, and carboplatin in a triple sequential high-dose regimen for patients with metastatic breast cancer. Analysis was performed on 61 women with chemotherapy-responsive metastatic breast cancer receiving 96-h infusional /"cyclophosphamide"/ as part of a triple sequential high-dose regimen to assess association between presence of peritransplant /"congestive heart failure"/ (/"CHF"/) and the following pretreatment characteristics: presence of electrocardiogram (EKG) abnormalities, age, hypertension, prior cardiac history, smoking, diabetes mellitus, prior use of anthracyclines, and left-sided chest irradiation. RESULTS: Six of 61 women (10%) developed clinically reversible grade 3 /"CHF"/ following infusional /"cyclophosphamide"/ with a median percent decline in ejection fraction of 31%. Incidence of transient /"cyclophosphamide"/-related cardiac toxicity (10%) is comparable to previous recorded literature. Older age was significantly correlated with the /"CHF"/ development; with median ages for the entire group and for patients developing /"CHF"/ of 45 and 59, respectively. No association was found with other pretreatment characteristics. CONCLUSIONS: As a result of these findings, oncologists should carefully monitor fluid balance in older patients. Routine EKG monitoring during infusional /"cyclophosphamide"/ did not predict /"CHF"/ development. Question: Does chemical /"cyclophosphamide"/ induce disease /"congestive heart failure"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"anthracyclines"/ induces disease /"Cardiac toxicity"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: /"Cardiac toxicity"/ observed in association with high-dose cyclophosphamide-based chemotherapy for metastatic breast cancer. - Abstract: INTRODUCTION: Cyclophosphamide is an alkylating agent given frequently as a component of many conditioning regimens. In high doses, its nonhematological dose-limiting toxicity is cardiomyopathy. STUDY DESIGN: We combined paclitaxel, melphalan and high-dose cyclophosphamide, thiotepa, and carboplatin in a triple sequential high-dose regimen for patients with metastatic breast cancer. Analysis was performed on 61 women with chemotherapy-responsive metastatic breast cancer receiving 96-h infusional cyclophosphamide as part of a triple sequential high-dose regimen to assess association between presence of peritransplant congestive heart failure (CHF) and the following pretreatment characteristics: presence of electrocardiogram (EKG) abnormalities, age, hypertension, prior cardiac history, smoking, diabetes mellitus, prior use of /"anthracyclines"/, and left-sided chest irradiation. RESULTS: Six of 61 women (10%) developed clinically reversible grade 3 CHF following infusional cyclophosphamide with a median percent decline in ejection fraction of 31%. Incidence of transient cyclophosphamide-related /"cardiac toxicity"/ (10%) is comparable to previous recorded literature. Older age was significantly correlated with the CHF development; with median ages for the entire group and for patients developing CHF of 45 and 59, respectively. No association was found with other pretreatment characteristics. CONCLUSIONS: As a result of these findings, oncologists should carefully monitor fluid balance in older patients. Routine EKG monitoring during infusional cyclophosphamide did not predict CHF development. Question: Does chemical /"anthracyclines"/ induce disease /"Cardiac toxicity"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"carbamazepine"/ induces disease /"absence seizures"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Inappropriate use of /"carbamazepine"/ and vigabatrin in typical /"absence seizures"/. - Abstract: /"Carbamazepine"/ and vigabatrin are contraindicated in typical /"absence seizures"/. Of 18 consecutive referrals of children with resistant typical absences only, eight were erroneously treated with /"carbamazepine"/ either as monotherapy or as an add-on. Vigabatrin was also used in the treatment of two children. Frequency of absences increased in four children treated with /"carbamazepine"/ and two of these developed myoclonic jerks, which resolved on withdrawal of /"carbamazepine"/. Absences were aggravated in both cases where vigabatrin was added on to concurrent treatment. Optimal control of the absences was achieved with sodium valproate, lamotrigine, or ethosuximide alone or in combination. Question: Does chemical /"carbamazepine"/ induce disease /"absence seizures"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"carbamazepine"/ induces disease /"myoclonic jerks"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Inappropriate use of /"carbamazepine"/ and vigabatrin in typical absence seizures. - Abstract: /"Carbamazepine"/ and vigabatrin are contraindicated in typical absence seizures. Of 18 consecutive referrals of children with resistant typical absences only, eight were erroneously treated with /"carbamazepine"/ either as monotherapy or as an add-on. Vigabatrin was also used in the treatment of two children. Frequency of absences increased in four children treated with /"carbamazepine"/ and two of these developed /"myoclonic jerks"/, which resolved on withdrawal of /"carbamazepine"/. Absences were aggravated in both cases where vigabatrin was added on to concurrent treatment. Optimal control of the absences was achieved with sodium valproate, lamotrigine, or ethosuximide alone or in combination. Question: Does chemical /"carbamazepine"/ induce disease /"myoclonic jerks"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"vigabatrin"/ induces disease /"absence seizures"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Inappropriate use of carbamazepine and /"vigabatrin"/ in typical /"absence seizures"/. - Abstract: Carbamazepine and /"vigabatrin"/ are contraindicated in typical /"absence seizures"/. Of 18 consecutive referrals of children with resistant typical absences only, eight were erroneously treated with carbamazepine either as monotherapy or as an add-on. /"Vigabatrin"/ was also used in the treatment of two children. Frequency of absences increased in four children treated with carbamazepine and two of these developed myoclonic jerks, which resolved on withdrawal of carbamazepine. Absences were aggravated in both cases where /"vigabatrin"/ was added on to concurrent treatment. Optimal control of the absences was achieved with sodium valproate, lamotrigine, or ethosuximide alone or in combination. Question: Does chemical /"vigabatrin"/ induce disease /"absence seizures"/ according to this article? Respond with "Yes" or "No" only. [/INST] Yes. </s>

Yes

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"ethosuximide"/ induces disease /"absence seizures"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Inappropriate use of carbamazepine and vigabatrin in typical /"absence seizures"/. - Abstract: Carbamazepine and vigabatrin are contraindicated in typical /"absence seizures"/. Of 18 consecutive referrals of children with resistant typical absences only, eight were erroneously treated with carbamazepine either as monotherapy or as an add-on. Vigabatrin was also used in the treatment of two children. Frequency of absences increased in four children treated with carbamazepine and two of these developed myoclonic jerks, which resolved on withdrawal of carbamazepine. Absences were aggravated in both cases where vigabatrin was added on to concurrent treatment. Optimal control of the absences was achieved with sodium valproate, lamotrigine, or /"ethosuximide"/ alone or in combination. Question: Does chemical /"ethosuximide"/ induce disease /"absence seizures"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No

<s> [INST] <<SYS>> Your task is to analyse the following medical article to determine whether chemical /"ethosuximide"/ induces disease /"myoclonic jerks"/. You only need to answer Yes or No, nothing else. <</SYS>> - Title: Inappropriate use of carbamazepine and vigabatrin in typical absence seizures. - Abstract: Carbamazepine and vigabatrin are contraindicated in typical absence seizures. Of 18 consecutive referrals of children with resistant typical absences only, eight were erroneously treated with carbamazepine either as monotherapy or as an add-on. Vigabatrin was also used in the treatment of two children. Frequency of absences increased in four children treated with carbamazepine and two of these developed /"myoclonic jerks"/, which resolved on withdrawal of carbamazepine. Absences were aggravated in both cases where vigabatrin was added on to concurrent treatment. Optimal control of the absences was achieved with sodium valproate, lamotrigine, or /"ethosuximide"/ alone or in combination. Question: Does chemical /"ethosuximide"/ induce disease /"myoclonic jerks"/ according to this article? Respond with "Yes" or "No" only. [/INST] No. </s>

No