| | Name Took office Left office Party Notes/Events |
| | 1 Benjamin Contee March 4, 1789 March 3, 1791 Anti-Administration |
| | 2 William Pinkney March 4, 1791 November, 1791 Pro-Administration resigned |
| | 3 John Francis Mercer February 5, 1792 March 3, 1793 Anti-Administration |
| | 4 Uriah Forrest March 4, 1793 November 8, 1794 Pro-Administration resigned |
| | 5 Benjamin Edwards January 2, 1795 March 3, 1795 Pro-Administration |
| | 6 Jeremiah Crabb March 4, 1795 June 1, 1796 Federalist resigned |
| | 7 William Craik December 5, 1796 March 3, 1801 Federalist |
| | 8 Thomas Plater March 4, 1801 March 3, 1805 Federalist |
| | 9 Patrick Magruder March 4, 1805 March 3, 1807 Democratic-Republican |
| | 10 Philip Barton Key March 4, 1807 March 3, 1813 Federalist |
| | 11 Alexander Contee Hanson March 4, 1813 1816 Federalist resigned |
| | 12 George Peter October 7, 1816 March 3, 1819 Federalist |
| | 13 Henry Ridgely Warfield March 4, 1819 March 3, 1823 Federalist |
| | 13 Henry Ridgely Warfield March 4, 1823 March 3, 1825 Adams Federalist |
| | 14 George Peter March 4, 1825 March 3, 1827 Jacksonian |
| | 15 George Corbin Washington March 4, 1827 March 3, 1829 Adams |
| | 15 George Corbin Washington March 4, 1829 March 3, 1833 Anti-Jacksonian |
| | 17 James Turner March 4, 1833 March 3, 1837 Jacksonian |
| | 18 John Tolley Hood Worthington March 4, 1837 March 3, 1841 Democratic |
| | 19 James Wray Williams March 4, 1841 December 2, 1842 Democratic died |
| | 20 Charles S. Sewall January 2, 1843 March 3, 1843 Democratic |
| | 21 John Wethered March 4, 1843 March 3, 1845 Whig |
| | 22 Thomas Watkins Ligon March 4, 1845 March 3, 1849 Democratic |
| | 23 Edward Hammond March 4, 1849 March 3, 1853 Democratic |
| | 24 Joshua Van Sant March 4, 1853 March 3, 1855 Democratic |
| | 25 James Morrison Harris March 4, 1855 March 3, 1861 Know-Nothing |
| | 26 Cornelius Lawrence Ludlow Leary March 4, 1861 March 3, 1863 Unionist |
| | 27 Henry Winter Davis March 4, 1863 March 3, 1865 Unconditional Unionist |
| | 28 Charles Edward Phelps March 4, 1865 March 3, 1867 Unconditional Unionist |
| | 28 Charles Edward Phelps March 4, 1867 March 4, 1869 Conservative |
| | 29 Thomas Swann March 4, 1869 March 3, 1873 Democratic Redistricted to the 4th district |
| | 30 William James O'Brien March 4, 1873 March 3, 1877 Democratic |
| | 31 William Kimmel March 4, 1877 March 3, 1881 Democratic |
| | 32 Fetter Schrier Hoblitzell March 4, 1881 March 3, 1885 Democratic |
| | 33 William Hinson Cole March 4, 1885 July 8, 1886 Democratic died |
| | 34 Harry Welles Rusk November 2, 1886 March 3, 1897 Democratic |
| | 35 William Samuel Booze March 4, 1897 March 3, 1899 Republican |
| | 36 Frank Charles Wachter March 4, 1899 March 3, 1907 Democratic |
| | 37 Harry Benjamin Wolf March 4, 1907 March 3, 1909 Democratic |
| | 38 John Kronmiller March 4, 1909 March 3, 1911 Republican |
| | 39 George Konig March 4, 1911 May 31, 1913 Democratic died |
| | 40 Charles Pearce Coady November 4, 1913 March 3, 1921 Democratic |
| | 41 John Boynton Philip Clayton Hill March 4, 1921 March 3, 1927 Republican |
| | 42 Vincent Palmisano March 4, 1927 January 3, 1939 Democratic |
| | 43 Thomas D'Alesandro, Jr. January 3, 1939 May 16, 1947 Democratic resigned to become Mayor of Baltimore |
| | 44 Edward Garmatz July 15, 1947 January 3, 1973 Democratic |
| | 45 Paul Sarbanes January 3, 1973 January 3, 1977 Democratic Redistricted from the 4th district |
| | 46 Barbara Mikulski January 3, 1977 January 3, 1987 Democratic |
| | 47 Benjamin Cardin January 3, 1987 January 3, 2007 Democratic |
| | 48 John Sarbanes January 3, 2007 Incumbent Democratic |
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