Datasets:

Stardrums

/

pico-breast-cancer

like 2

[ "Three", "-", "year", "follow", "-", "up", "from", "a", "phase", "3", "study", "of", "SB", "3", "(", "a", "trastuzumab", "biosimilar", ")", "versus", "reference", "trastuzumab", "in", "the", "neoadjuvant", "setting", "for", "human", "epidermal", "growth", "factor", "receptor", "2", "-positive", "breast", "cancer", ".", "We", "assessed", "long", "-", "term", "cardiac", "safety", "and", "efficacy", "in", "patients", "with", "human", "epidermal", "growth", "factor", "receptor", "2", "-positive", "early", "breast", "cancer", "treated", "with", "a", "trastuzumab", "biosimilar", "(", "SB", "3", ")", "or", "its", "reference", "product", ",", "trastuzumab", "(", "TRZ", ")", ",", "in", "a", "phase", "3", "study", ".", "Patients", "who", "completed", "the", "phase", "3", "study", "could", "be", "enrolled", "in", "this", "extension", "study", ".", "The", "outcomes", "included", "the", "incidence", "of", "symptomatic", "congestive", "heart", "failure", "(", "CHF", ")", ",", "asymptomatic", "significant", "left", "ventricular", "ejection", "fraction", "(", "LVEF", ")", "decrease", ",", "incidence", "of", "other", "cardiac", "events", ",", "event", "-", "free", "survival", "(", "EFS", ")", ",", "and", "overall", "survival", ".", "In", "post", "hoc", "analysis", ",", "the", "Cox", "proportional", "hazards", "regression", "model", "was", "used", "to", "assess", "factors", "associated", "with", "EFS", ".", "A", "total", "of", "367", "patients", "were", "enrolled", "in", "the", "study", "(", "SB", "3", ",", "n", "=", "186", ";", "TRZ", ",", "n", "=", "181", ")", ".", "The", "median", "follow", "-", "up", "duration", "from", "the", "main", "study", "enrolment", "was", "40.8", "and", "40.5", "months", "for", "SB", "3", "and", "TRZ", ",", "respectively", ".", "During", "the", "two", "-", "year", "follow", "-", "up", "after", "adjuvant", "therapy", ",", "incidence", "of", "asymptomatic", "significant", "LVEF", "decrease", "was", "rare", "(", "SB", "3", ",", "n", "=", "1", ";", "TRZ", ",", "n", "=", "2", ")", ",", "with", "all", "patients", "recovering", "with", "LVEF", "≥", "50", "%", ",", "and", "no", "cases", "of", "symptomatic", "CHF", "or", "other", "cardiac", "events", "were", "reported", ".", "At", "3", "years", ",", "the", "EFS", "was", "91.9", "%", "with", "SB", "3", "and", "85.2", "%", "with", "TRZ", ".", "The", "number", "of", "patients", "with", "events", "was", "17", "(", "9.1", "%", ")", "with", "SB", "3", "and", "31", "(", "17.1", "%", ")", "with", "TRZ", "[", "hazard", "ratio", ":", "0.47", ",", "95", "%", "confidence", "interval", ":", "0.26", "-", "0.87", "]", ".", "Antibody", "-", "dependent", "cell", "-", "mediated", "cytotoxicity", "(", "ADCC", ")", "activity", "and", "the", "breast", "pathologic", "complete", "response", "rate", "were", "the", "factors", "associated", "with", "EFS", ".", "Cardiotoxicity", "was", "rare", "in", "this", "extension", "study", ".", "EFS", "was", "higher", "with", "SB", "3", "versus", "TRZ", ",", "with", "post", "hoc", "analysis", "suggesting", "that", "a", "downward", "drift", "in", "ADCC", "activity", "was", "a", "contributing", "factor", ".", "NCT", "02771795", "(", "EudraCT", "2015", "-", "005663", "-", "17", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 18, 18, 18, 18, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 25, 0, 0, 0, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 29, 30, 0, 0, 0, 0, 31, 32, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 25, 0, 29, 30, 0, 0, 0, 0, 0, 27, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Randomized", "trial", "of", "a", "physical", "activity", "intervention", "in", "women", "with", "metastatic", "breast", "cancer", ".", "Exercise", "interventions", "improve", "fitness", ",", "functional", "capacity", ",", "and", "quality", "of", "life", "in", "patients", "with", "early", "-", "stage", "breast", "cancer", ",", "but", "to", "the", "authors", "'", "knowledge", "there", "are", "few", "data", "regarding", "the", "feasibility", "or", "potential", "benefits", "of", "exercise", "in", "women", "with", "metastatic", "breast", "cancer", ".", "Individuals", "with", "metastatic", "breast", "cancer", "were", "randomized", "1", ":1", "to", "a", "16", "-week", "moderate", "-", "intensity", "exercise", "intervention", "or", "wait", "-", "list", "control", "group", ".", "Intervention", "goals", "included", "150", "minutes", "of", "moderate", "-", "intensity", "aerobic", "exercise", "per", "week", ".", "The", "baseline", "and", "16", "-week", "evaluations", "included", "a", "modified", "Bruce", "Ramp", "treadmill", "test", ",", "7", "-day", "Physical", "Activity", "Recall", "interview", ",", "and", "European", "Organization", "for", "Research", "and", "Treatment", "of", "Cancer", "Quality", "of", "Life", "Questionnaire", "Core", "30", "(", "EORTC", "QLQ", "C-", "30", ")", "questionnaire", ".", "A", "total", "of", "101", "participants", "were", "randomized", "(", "48", "to", "the", "intervention", "group", "and", "53", "to", "the", "control", "group", ")", ".", "The", "median", "age", "of", "the", "participants", "was", "49", "years", ",", "the", "median", "time", "since", "the", "diagnosis", "of", "metastatic", "breast", "cancer", "was", "1.1", "years", ",", "and", "approximately", "42", "%", "of", "participants", "were", "undergoing", "chemotherapy", "at", "the", "time", "of", "enrollment", ".", "Study", "attrition", "was", "higher", "in", "the", "intervention", "arm", "(", "14", "participants", "vs", "8", "participants", ";", "P", "=", ".", "15", ")", ".", "Women", "randomized", "to", "the", "exercise", "intervention", "experienced", "a", "nonsignificant", "increase", "with", "regard", "to", "minutes", "of", "weekly", "exercise", "(", "62.4", "minutes", "vs", "46.0", "minutes", ";", "P", "=", ".", "17", ")", "and", "physical", "functioning", "(", "EORTC", "QLQ", "C", "30", ":", "4.79", "vs", "0.93", "[", "P", "=", ".", "23", "]", "and", "Bruce", "Ramp", "Treadmill", "test", ":", "0.61", "minutes", "vs", "0.37", "minutes", "[", "P", "=", ".", "35", "]", ")", "compared", "with", "control", "participants", ".", "Participation", "in", "an", "exercise", "intervention", "did", "not", "appear", "to", "result", "in", "significant", "improvements", "in", "physical", "functioning", "in", "a", "heterogeneous", "group", "of", "women", "living", "with", "advanced", "breast", "cancer", ".", "Given", "the", "significant", "benefits", "of", "exercise", "in", "women", "with", "early", "-", "stage", "breast", "cancer", ",", "more", "work", "is", "needed", "to", "explore", "alternative", "interventions", "to", "determine", "whether", "exercise", "could", "help", "women", "with", "metastatic", "disease", "live", "more", "fully", "with", "fewer", "symptoms", "from", "disease", "and", "treatment", "." ]

[ 0, 0, 0, 0, 17, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 20, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 25, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 33, 34, 0, 35, 36, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 33, 0, 35, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 33, 34, 0, 35, 36, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "BREATH", ":", "Web", "-", "Based", "Self", "-", "Management", "for", "Psychological", "Adjustment", "After", "Primary", "Breast", "Cancer", "--", "Results", "of", "a", "Multicenter", "Randomized", "Controlled", "Trial", ".", "Early", "breast", "cancer", "survivors", "(", "BCSs", ")", "report", "high", "unmet", "care", "needs", ",", "and", "easily", "accessible", "care", "is", "not", "routinely", "available", "for", "this", "growing", "population", ".", "The", "Breast", "Cancer", "E", "-", "Health", "(", "BREATH", ")", "trial", "is", "a", "Web", "-", "based", "self", "-", "management", "intervention", "to", "support", "the", "psychological", "adjustment", "of", "women", "after", "primary", "treatment", ",", "by", "reducing", "distress", "and", "improving", "empowerment", ".", "This", "multicenter", ",", "randomized", ",", "controlled", ",", "parallel", "-", "group", "trial", "evaluated", "whether", "care", "as", "usual", "(", "CAU", ")", "plus", "BREATH", "is", "superior", "to", "CAU", "alone", ".", "BREATH", "is", "delivered", "in", "sixteen", "fully", "automated", "weekly", "modules", "covering", "early", "survivorship", "issues", ".", "Two", "to", "4", "months", "post", "-", "treatment", ",", "BCSs", "were", "randomly", "assigned", "to", "receive", "CAU", "+", "BREATH", "(", "n", "=", "70", ")", "or", "CAU", "alone", "(", "n", "=", "80", ")", "using", "a", "stratified", "block", "design", "(", "ratio", "1", ":1", ")", ".", "Primary", "outcomes", "were", "distress", "(", "Symptom", "Checklist-", "90", ")", "and", "empowerment", "(", "Cancer", "Empowerment", "Questionnaire", ")", ",", "assessed", "before", "random", "assignment", "(", "baseline", ",", "T", "0", ")", "and", "after", "4", "(", "T", "1", ")", ",", "6", "(", "T", "2", ")", ",", "and", "10", "months", "(", "T", "3", ")", "of", "follow", "-", "up", ".", "Statistical", "(", "analysis", "of", "covariance", ")", "and", "clinical", "effects", "(", "reliable", "change", "index", ")", "were", "tested", "in", "an", "intention", "-", "to", "-", "treat", "analysis", "(", "T", "0", "to", "T", "1", ")", ".", "Follow", "-", "up", "effects", "(", "T", "0", "to", "T", "3", ")", "were", "assessed", "in", "assessment", "completers", ".", "CAU", "+", "BREATH", "participants", "reported", "significantly", "less", "distress", "than", "CAU", "-", "alone", "participants", "(", "-", "7.79", ";", "95", "%", "CI", ",", "-", "14.31", "to", "-", "1.27", ";", "P", "=", ".", "02", ")", "with", "a", "small", "-", "to", "-", "medium", "effect", "size", "(", "d", "=", "0.33", ")", ",", "but", "empowerment", "was", "not", "affected", "(", "-", "1.71", ";", "95", "%", "CI", ",", "5.20", "to", "-", "1.79", ";", "P", "=", ".", "34", ")", ".", "More", "CAU", "+", "BREATH", "participants", "(", "39", "of", "70", "[", "56", "%", "]", ";", "95", "%", "CI", ",", "44.1", "to", "66.8", ")", "than", "CAU", "-", "alone", "participants", "(", "32", "of", "80", "[", "40", "%", "]", ";", "95", "%", "CI", ",", "30.0", "to", "51.0", ")", "showed", "clinically", "significant", "improvement", "(", "P", "=", ".", "03", ")", ".", "This", "clinical", "effect", "was", "most", "prominent", "in", "low", "-", "distress", "BCSs", ".", "Secondary", "outcomes", "confirmed", "primary", "outcomes", ".", "There", "were", "no", "between", "-", "group", "differences", "in", "primary", "outcomes", "during", "follow", "-", "up", ".", "Access", "to", "BREATH", "reduced", "distress", "among", "BCSs", ",", "but", "this", "effect", "was", "not", "sustained", "during", "follow", "-", "up", "." ]

[ 0, 0, 17, 18, 18, 18, 18, 18, 0, 13, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 19, 20, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 25, 0, 3, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 27, 0, 5, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Elevated", "plasma", "endoglin", "(", "CD", "105", ")", "predicts", "decreased", "response", "and", "survival", "in", "a", "metastatic", "breast", "cancer", "trial", "of", "hormone", "therapy", ".", "Background", "Endoglin", "(", "CD", "105", ")", "is", "a", "co", "-", "receptor", "for", "TGF", "-", "beta", ",", "is", "expressed", "by", "human", "vascular", "endothelial", "cells", ",", "and", "plays", "a", "major", "role", "in", "angiogenesis", ".", "Materials", "and", "methods", "Pretreatment", "EDTA", "plasma", "from", "224", "metastatic", "breast", "cancer", "patients", "enrolled", "in", "a", "phase", "III", "2", "nd", "-", "line", "hormone", "therapy", "trial", "and", "50", "control", "subjects", "were", "assayed", "for", "endoglin", "using", "an", "ELISA", ".", "Results", "The", "female", "control", "group", "(", "n", "=", "50", ")", "plasma", "endoglin", "upper", "limit", "of", "normal", "was", "defined", "as", "the", "mean", "+", "2", "SD", "(", "8.7", "ng", "/", "ml", ")", ".", "The", "breast", "cancer", "patient", "plasma", "endoglin", "was", "6.40", "+", "/-", "2.23", "ng", "/", "ml", "(", "range", "3.00", "-", "19.79", "ng", "/", "ml", ")", ".", "Elevated", "plasma", "endoglin", "levels", "were", "detected", "in", "26", "of", "224", "patients", "(", "11.6", "%", ")", ".", "Patients", "with", "elevated", "plasma", "endoglin", "had", "a", "reduced", "clinical", "benefit", "rate", "(", "CR", "+", "PR", "+", "Stable", ")", "(", "15", "vs.", "42", "%", ")", "(", "P", "=", "0.01", ")", "to", "hormone", "therapy", ".", "TTP", "was", "shorter", "for", "patients", "with", "elevated", "plasma", "endoglin", ",", "but", "did", "not", "reach", "statistical", "significance", "(", "P", "=", "0.2", ")", ".", "Patients", "with", "elevated", "plasma", "endoglin", "had", "decreased", "overall", "survival", "(", "median", "645", "vs.", "947", "days", ")", "(", "P", "=", "0.005", ")", ".", "Conclusion", "Elevated", "pretreatment", "plasma", "endoglin", "levels", "predicted", "for", "decreased", "clinical", "benefit", "and", "a", "shorter", "overall", "survival", "in", "metastatic", "breast", "cancer", "patients", "treated", "with", "2", "nd", "-", "line", "hormone", "therapy", "." ]

[ 17, 18, 18, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 25, 0, 3, 0, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 29, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 37, 0, 39, 40, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Web", "-", "Based", "Tailored", "Psychoeducation", "for", "Breast", "Cancer", "Patients", "at", "the", "Onset", "of", "the", "Survivorship", "Phase", ":", "A", "Multicenter", "Randomized", "Controlled", "Trial", ".", "Many", "breast", "cancer", "patients", "have", "unmet", "informational", "and", "psychosocial", "needs", "after", "treatment", "completion", ".", "A", "psychoeducational", "intervention", "may", "be", "well", "suited", "to", "support", "these", "patients", ".", "The", "purpose", "of", "this", "multicenter", "randomized", "controlled", "trial", "was", "to", "examine", "the", "effectiveness", "of", "a", "web", "-", "based", "tailored", "psychoeducational", "program", "(", "ENCOURAGE", ")", "for", "breast", "cancer", "patients", ",", "which", "aims", "to", "empower", "patients", "to", "take", "control", "over", "prevailing", "problems", ".", "Female", "breast", "cancer", "patients", "from", "two", "hospitals", "in", "The", "Netherlands", "who", "recently", "completed", "(", "neo-", ")", "adjuvant", "chemotherapy", "were", "randomly", "assigned", "to", "standard", "care", "or", "12", "-week", "access", "to", "the", "ENCOURAGE", "program", "providing", "fully", "automated", "information", "problem", "-", "solving", "strategies", ",", "resources", ",", "and", "services", "for", "reported", "problems", ".", "At", "six", "and", "12", "weeks", ",", "patients", "completed", "self", "-", "report", "questions", "on", "optimism", "and", "control", "over", "the", "future", "(", "primary", "outcome", ")", ",", "feelings", "of", "being", "informed", ",", "and", "acceptance", "of", "the", "illness", ".", "At", "baseline", "and", "12", "weeks", ",", "distress", "and", "quality", "of", "life", "questionnaires", "were", "completed", ".", "About", "138", "patients", "were", "included", ".", "Almost", "all", "patients", "(", "67", "of", "69", ")", "visited", "ENCOURAGE", "as", "requested", ".", "No", "differences", "between", "the", "control", "and", "intervention", "group", "were", "observed", "for", "primary", "and", "secondary", "outcomes", ".", "An", "unplanned", "subgroup", "analysis", "showed", "that", "in", "clinically", "distressed", "patients", "(", "N", "=", "57", "at", "baseline", ";", "41", "%", ")", ",", "use", "of", "the", "ENCOURAGE", "program", "increased", "optimism", "and", "control", "over", "the", "future", "at", "12", "weeks", "more", "than", "in", "patients", "in", "the", "control", "group", "(", "Cohen", "'s", "d", "=", "0.65", ")", ".", "Although", "the", "effectiveness", "was", "not", "demonstrated", ",", "a", "subgroup", "of", "women", "treated", "for", "breast", "cancer", "can", "probably", "be", "supported", "by", "the", "program", ".", "The", "results", "of", "the", "present", "study", "are", "a", "starting", "point", "for", "further", "development", "and", "use", "of", "the", "program", "." ]

[ 17, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 16, 9, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 23, 24, 24, 24, 0, 0, 23, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 25, 0, 3, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Physical", "function", "of", "the", "upper", "limb", "after", "breast", "cancer", "surgery", ".", "Results", "from", "the", "SOUND", "(", "Sentinel", "node", "vs.", "Observation", "after", "axillary", "Ultra", "-", "souND", ")", "trial", ".", "The", "SOUND", "(", "Sentinel", "node", "vs.", "Observation", "after", "axillary", "Ultra", "-", "souND", ")", "trial", "is", "an", "ongoing", "prospective", "randomized", "study", "comparing", "sentinel", "node", "biopsy", "vs.", "no", "axillary", "surgical", "staging", "in", "patients", "with", "small", "breast", "cancer", "and", "negative", "pre", "-", "operative", "ultra", "-", "sound", "of", "the", "axilla", ".", "The", "first", "180", "recruited", "patients", "were", "administered", "the", "QuickDASH", "(", "Disability", "Arm", "and", "Shoulder", ")", "questionnaire", "at", "different", "time", "points", "(", "before", "surgery", ",", "1", "week", ",", "6", "months", "and", "1", "year", "after", "surgery", ")", "to", "evaluate", "the", "physical", "function", "of", "the", "ipsilateral", "upper", "limb", ",", "The", "QuickDASH", "score", "ranges", "from", "0", "(", "no", "disability", ")", "to", "100", "(", "complete", "disability", ")", ".", "176", "patients", "were", "available", "for", "analysis", "(", "94", "in", "SNB", "arm", "and", "82", "in", "observation", "arm", ")", ".", "The", "two", "groups", "were", "comparable", "with", "respect", "to", "age", ",", "tumor", "characteristics", "and", "treatments", ".", "Pre", "-", "surgery", "score", "values", "were", "3.0", "%", "and", "2.7", "%", "in", "the", "SNB", "arm", "and", "observation", "arm", ",", "respectively", "(", "P", "=", "0.730", ")", ".", "One", "week", "after", "surgery", ",", "the", "score", "increased", "to", "24.0", "%", "in", "the", "SNB", "arm", "and", "10.6", "%", "in", "the", "observation", "arm", "(", "P", "<", "0.001", ")", ".", "After", "6", "and", "12", "months", ",", "the", "score", "decreased", "in", "both", "arms", "to", "values", "similar", "to", "baseline", "values", ".", "The", "overall", "trend", "in", "time", "of", "the", "score", "was", "significantly", "different", "between", "the", "two", "arms", "(", "P", "<", "0.001", ")", ",", "even", "after", "the", "exclusion", "of", "five", "patients", "who", "received", "AD", "in", "the", "SNB", "arm", "(", "P", "<", "0.001", ")", ".", "Patients", "who", "underwent", "SNB", "had", "a", "significantly", "higher", "rate", "of", "disability", "in", "the", "early", "post", "-", "operative", "period", "compared", "to", "patients", "who", "did", "not", ".", "The", "avoidance", "of", "SNB", "might", "translate", "into", "a", "considerable", "reduction", "of", "physical", "and", "emotional", "distress", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 0, 19, 20, 20, 20, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 33, 34, 0, 35, 36, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 21, 0, 0, 33, 34, 0, 0, 0, 0, 0, 35, 36, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Overweight", ",", "Obesity", ",", "and", "Postmenopausal", "Invasive", "Breast", "Cancer", "Risk", ":", "A", "Secondary", "Analysis", "of", "the", "Women", "'s", "Health", "Initiative", "Randomized", "Clinical", "Trials", ".", "More", "than", "two", "-", "thirds", "of", "US", "women", "are", "overweight", "or", "obese", ",", "placing", "them", "at", "increased", "risk", "for", "postmenopausal", "breast", "cancer", ".", "To", "investigate", "in", "this", "secondary", "analysis", "the", "associations", "of", "overweight", "and", "obesity", "with", "risk", "of", "postmenopausal", "invasive", "breast", "cancer", "after", "extended", "follow", "-", "up", "in", "the", "Women", "'s", "Health", "Initiative", "(", "WHI", ")", "clinical", "trials", ".", "The", "WHI", "clinical", "trial", "protocol", "incorporated", "measured", "height", "and", "weight", ",", "baseline", "and", "annual", "or", "biennial", "mammography", ",", "and", "adjudicated", "breast", "cancer", "end", "points", "in", "67", "142", "postmenopausal", "women", "ages", "50", "to", "79", "years", "at", "40", "US", "clinical", "centers", ".", "The", "women", "were", "enrolled", "from", "1993", "to", "1998", "with", "a", "median", "of", "13", "years", "of", "follow", "-", "up", "through", "2010", ";", "3388", "invasive", "breast", "cancers", "were", "observed", ".", "Height", "and", "weight", "were", "measured", "at", "baseline", ",", "and", "weight", "was", "measured", "annually", "thereafter", ".", "Data", "were", "collected", "on", "demographic", "characteristics", ",", "personal", "and", "family", "medical", "history", ",", "and", "personal", "habits", "(", "smoking", ",", "physical", "activity", ")", ".", "Women", "underwent", "annual", "or", "biennial", "mammograms", ".", "Breast", "cancers", "were", "verified", "by", "medical", "records", "reviewed", "by", "physician", "adjudicators", ".", "Women", "who", "were", "overweight", "and", "obese", "had", "an", "increased", "invasive", "breast", "cancer", "risk", "vs", "women", "of", "normal", "weight", ".", "Risk", "was", "greatest", "for", "obesity", "grade", "2", "plus", "3", "(", "body", "mass", "index", "[", "BMI", "]", ",", "calculated", "as", "weight", "in", "kilograms", "divided", "by", "height", "in", "meters", "squared", ",", ">", "35.0", ")", "(", "hazard", "ratio", "[", "HR", "]", "for", "invasive", "breast", "cancer", ",", "1.58", ";", "95", "%", "CI", ",", "1.40", "-", "1.79", ")", ".", "A", "BMI", "of", "35.0", "or", "higher", "was", "strongly", "associated", "with", "risk", "for", "estrogen", "receptor", "-", "positive", "and", "progesterone", "receptor", "-", "positive", "breast", "cancers", "(", "HR", ",", "1.86", ";", "95", "%", "CI", ",", "1.60", "-", "2.17", ")", "but", "was", "not", "associated", "with", "estrogen", "receptor", "-", "negative", "cancers", ".", "Obesity", "grade", "2", "plus", "3", "was", "also", "associated", "with", "advanced", "disease", ",", "including", "larger", "tumor", "size", "(", "HR", ",", "2.12", ";", "95", "%", "CI", ",", "1.67", "-", "2.69", ";", "P", "=", ".", "02", ")", ",", "positive", "lymph", "nodes", "(", "HR", ",", "1.89", ";", "95", "%", "CI", ",", "1.46", "-", "2.45", ";", "P", "=", ".", "06", ")", ",", "regional", "and/or", "distant", "stage", "(", "HR", ",", "1.94", ";", "95", "%", "CI", ",", "1.52", "-", "2.47", ";", "P", "=", ".", "05", ")", ",", "and", "deaths", "after", "breast", "cancer", "(", "HR", ",", "2.11", ";", "95", "%", "CI", ",", "1.57", "-", "2.84", ";", "P", "<", ".", "001", ")", ".", "Women", "with", "a", "baseline", "BMI", "of", "less", "than", "25.0", "who", "gained", "more", "than", "5", "%", "of", "body", "weight", "over", "the", "follow", "-", "up", "period", "had", "an", "increased", "breast", "cancer", "risk", "(", "HR", ",", "1.36", ";", "95", "%", "CI", ",", "1.1", "-", "1.65", ")", ",", "but", "among", "women", "already", "overweight", "or", "obese", "we", "found", "no", "association", "of", "weight", "change", "(", "gain", "or", "loss", ")", "with", "breast", "cancer", "during", "follow", "-", "up", ".", "There", "was", "no", "effect", "modification", "of", "the", "BMI", "-", "breast", "cancer", "relationship", "by", "postmenopausal", "hormone", "therapy", ",", "and", "the", "direction", "of", "association", "across", "BMI", "categories", "was", "similar", "for", "never", ",", "past", ",", "and", "current", "hormone", "therapy", "use", ".", "Obesity", "is", "associated", "with", "increased", "invasive", "breast", "cancer", "risk", "in", "postmenopausal", "women", ".", "These", "clinically", "meaningful", "findings", "should", "motivate", "programs", "for", "obesity", "prevention", ".", "clinicaltrials.gov", "Identifier", ":", "NCT", "00000611", "." ]

[ 17, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 9, 10, 0, 7, 8, 8, 8, 0, 0, 15, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Pilot", "randomised", "controlled", "trial", "of", "a", "radiation", "therapist", "-", "led", "educational", "intervention", "for", "breast", "cancer", "patients", "prior", "to", "commencing", "radiotherapy", ".", "Although", "patients", "receive", "information", "prior", "to", "commencing", "radiotherapy", ",", "they", "often", "experience", "anxiety", "and", "distress", ".", "We", "conducted", "a", "pilot", "randomised", "controlled", "trial", "to", "determine", "whether", "a", "radiation", "therapist", "led", "psycho", "-", "educational", "intervention", "for", "breast", "cancer", "patients", "prior", "to", "radiotherapy", "is", "likely", "to", "be", "effective", "in", "reducing", "radiotherapy", "-", "related", "concerns", ",", "patient", "anxiety", "and", "depression", ".", "The", "intervention", "comprised", "two", "face", "-", "to", "-", "face", "consultations", "with", "a", "radiation", "therapist", "(", "one", "prior", "to", "radiation", "planning", "and", "the", "other", "prior", "to", "treatment", ")", ".", "Patients", "completed", "surveys", "at", "baseline", ",", "prior", "to", "treatment", "planning", "and", "on", "the", "first", "day", "of", "treatment", ".", "Outcome", "measures", "included", "the", "Hospital", "Anxiety", "and", "Depression", "Scale", ",", "Radiation", "Therapy", "Related", "Patient", "Concerns", "and", "Radiation", "Therapy", "Knowledge", "Scales", ".", "One", "hundred", "and", "twenty", "two", "patients", "completed", "baseline", "measures", ".", "Fifty", "-", "eight", "patients", "received", "usual", "care", ",", "and", "64", "received", "the", "intervention", ".", "After", "the", "first", "consultation", ",", "patient", "anxiety", "was", "significantly", "lower", "in", "the", "intervention", "group", "(", "p", "=", "0.048", ")", ",", "as", "were", "concerns", "about", "radiotherapy", "(", "p", "=", "0.001", ")", ".", "There", "were", "no", "differences", "between", "groups", "for", "depression", ".", "Patient", "knowledge", "for", "the", "intervention", "group", "was", "higher", "after", "the", "first", "consultation", "(", "p", "<", "0.001", ")", ".", "This", "intervention", "is", "likely", "to", "be", "effective", "in", "reducing", "patient", "anxiety", "and", "concerns", "and", "increasing", "knowledge", ".", "Future", "research", "is", "required", "to", "test", "this", "intervention", "with", "a", "larger", "population", "." ]

[ 0, 0, 0, 0, 0, 0, 17, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 13, 14, 14, 14, 14, 14, 14, 14, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 0, 23, 24, 24, 24, 24, 0, 23, 24, 24, 24, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 19, 20, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Tamoxifen", "alone", "versus", "adjuvant", "tamoxifen", "for", "operable", "breast", "cancer", "of", "the", "elderly", ":", "long", "-", "term", "results", "of", "the", "phase", "III", "randomized", "controlled", "multicenter", "GRETA", "trial", ".", "To", "evaluate", "the", "efficacy", "of", "tamoxifen", "as", "primary", "treatment", "in", "women", "aged", "over", "70", "years", "with", "operable", "breast", "cancer", "versus", "surgery", "followed", "by", "adjuvant", "tamoxifen", ".", "Patients", "randomly", "received", "tamoxifen", "alone", "(", "160", "mg", "day", "1", ",", "then", "20", "mg", "/", "day", ")", "for", "5", "years", "or", "surgery", "followed", "by", "tamoxifen", "(", "20", "mg", "/", "day", ")", "for", "5", "years", ".", "Overall", "survival", "was", "the", "main", "study", "end", "point", ";", "secondary", "objectives", "included", "breast", "cancer", "survival", "and", "local", "control", "of", "the", "disease", ".", "Between", "1987", "and", "1992", ",", "239", "patients", "were", "assigned", "to", "surgery", "plus", "tamoxifen", "and", "235", "to", "tamoxifen", "alone", ".", "Treatment", "arms", "were", "comparable", "for", "tumor", "size", ",", "clinical", "nodal", "status", "and", "performance", "status", ".", "At", "a", "median", "follow", "-", "up", "of", "80", "months", "274", "patients", "had", "died", ".", "No", "difference", "between", "groups", "had", "emerged", "in", "overall", "and", "breast", "cancer", "survival", ".", "There", "were", "27", "local", "progressions", "in", "the", "surgery", "plus", "tamoxifen", "group", "and", "106", "in", "the", "tamoxifen", "-", "alone", "group", "(", "P", "=", "0.0001", ")", ".", "In", "the", "surgery", "plus", "tamoxifen", "group", ",", "no", "difference", "in", "overall", "survival", "had", "emerged", "according", "to", "the", "extension", "of", "operation", ".", "The", "long", "-", "term", "results", "of", "the", "study", "confirm", "the", "3", "-year", "interim", "analysis", "already", "reported", ".", "Surgery", "(", "radical", "or", "minimal", ")", "followed", "by", "adjuvant", "tamoxifen", "does", "not", "modify", "overall", "and", "breast", "cancer", "survival", "as", "compared", "with", "tamoxifen", "alone", "in", "early", "breast", "cancer", "of", "older", "women", ".", "Because", "of", "the", "high", "rate", "of", "local", "progressions", "with", "tamoxifen", "alone", ",", "minimal", "surgery", "followed", "by", "tamoxifen", "appears", "to", "be", "the", "appropriate", "treatment", "in", "such", "patients", ".", "More", "extensive", "surgery", "is", "not", "useful", ".", "Tamoxifen", "alone", "is", "an", "adequate", "alternative", "treatment", "in", "very", "old", "or", "frail", "patients", "." ]

[ 17, 18, 0, 19, 20, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 0, 23, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 27, 21, 22, 0, 0, 0, 0, 0, 0, 0, 25, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "[", "Clinical", "comparative", "study", "of", "neoadjuvant", "chemotherapy", "outcome", "in", "locally", "advanced", "breast", "cancer", ":", "docetaxel", "versus", "paclitaxel", "plus", "pirarubicin", "hydrochloride", "and", "cyclophosphamide", "]", ".", "To", "compare", "the", "efficacy", "and", "toxicity", "of", "neoadjuvant", "chemotherapy", "of", "docetaxel", "with", "paclitaxel", "plus", "pirarubicin", "hydrochloride", "(", "THP", ")", "and", "cyclophosphamide", "(", "CTX", ")", "in", "locally", "advanced", "breast", "cancer", "(", "LABC", ")", ".", "A", "total", "of", "97", "LABC", "cases", "were", "randomly", "divided", "into", "2", "groups", ":", "docetaxel", "group", "(", "n", "=", "49", ",", "taxotere", "plus", "THP", "&", "CTX", ")", "and", "paclitaxel", "group", "(", "n", "=", "48", ",", "paclitaxel", "plus", "THP", "&", "CTX", ")", ".", "Neoadjuvant", "chemotherapy", "had", "four", "cycles", "of", "21", "days", "each", ".", "The", "clinical", "and", "pathological", "complete", "remission", "rates", "of", "docetaxel", "group", "was", "28.6", "%", "and", "26.5", "%", "respectively", ".", "They", "were", "significantly", "higher", "than", "those", "of", "paclitaxel", "group", "(", "10.4", "%", "and", "8.3", "%", ")", ".", "Furthermore", "the", "pathological", "negative", "rate", "of", "regional", "lymph", "node", "in", "docetaxel", "group", "was", "also", "significantly", "higher", "than", "that", "of", "paclitaxel", "group", "(", "40.6", "%", "vs.", "12.9", "%", ")", ".", "However", ",", "grade", "III", "-", "IV", "blood", "system", "toxic", "reaction", "was", "found", "in", "71.4", "%", "cases", ",", "grade", "II", "-", "IV", "liver", "dysfunction", "in", "53.1", "%", "cases", "and", "edema", "in", "24.5", "%", "cases", "among", "docetaxel", "group", ".", "They", "were", "higher", "than", "those", "among", "paclitaxel", "group", "(", "46.9", "%", ",", "27.1", "%", "&", "4.2", "%", ")", ".", "Compared", "with", "paclitaxel", ",", "the", "combined", "regimen", "of", "docetaxel", "plus", "THP", "and", "CTX", "offers", "better", "outcomes", "for", "locally", "advanced", "breast", "cancer", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 0, 19, 20, 20, 20, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 21, 22, 22, 22, 0, 0, 0, 0, 29, 30, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 31, 32, 0, 31, 32, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 29, 30, 0, 0, 21, 22, 22, 22, 22, 22, 0, 29, 30, 0, 0, 21, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 31, 32, 0, 31, 32, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Pegylated", "liposomal", "doxorubicin", "plus", "docetaxel", "significantly", "improves", "time", "to", "progression", "without", "additive", "cardiotoxicity", "compared", "with", "docetaxel", "monotherapy", "in", "patients", "with", "advanced", "breast", "cancer", "previously", "treated", "with", "neoadjuvant", "-", "adjuvant", "anthracycline", "therapy", ":", "results", "from", "a", "randomized", "phase", "III", "study", ".", "To", "determine", "whether", "the", "combination", "of", "pegylated", "liposomal", "doxorubicin", "(", "PLD", ")", "and", "docetaxel", "significantly", "prolongs", "time", "to", "disease", "progression", "compared", "with", "docetaxel", "alone", "without", "an", "increase", "in", "cardiac", "toxicity", "in", "women", "with", "advanced", "breast", "cancer", "who", "had", "experienced", "relapse", "at", "least", "1", "year", "after", "prior", "adjuvant", "or", "neoadjuvant", "anthracycline", "therapy", ".", "This", "international", ",", "phase", "III", "study", "randomly", "assigned", "751", "patients", "to", "receive", "either", "docetaxel", "75", "mg", "/", "m", "(", "2", ")", "(", "n", "=", "373", ")", "or", "PLD", "30", "mg", "/", "m", "(", "2", ")", "followed", "by", "docetaxel", "60", "mg", "/", "m", "(", "2", ")", "every", "21", "days", "(", "n", "=", "378", ")", "and", "continued", "until", "disease", "progression", "or", "prohibitive", "toxicity", ".", "The", "primary", "end", "point", "was", "time", "to", "progression", "(", "TTP", ")", ".", "Secondary", "end", "points", "were", "overall", "survival", "(", "OS", ")", ",", "objective", "response", "rate", "(", "ORR", ")", ",", "cardiac", "toxicity", ",", "and", "safety", ".", "Treatment", "with", "PLD", "-", "docetaxel", "significantly", "improved", "median", "TTP", "from", "7.0", "to", "9.8", "months", "(", "hazard", "ratio", "[", "HR", "]", "=", "0.65", ";", "95", "%", "CI", ",", "0.55", "to", "0.77", ";", "P", "=", ".", "000001", ")", "and", "the", "ORR", "from", "26", "%", "to", "35", "%", "(", "P", "=", ".", "0085", ")", ".", "OS", "was", "similar", "between", "the", "two", "groups", "(", "HR", "=", "1.02", ";", "95", "%", "CI", ",", "0.86", "to", "1.22", ")", ".", "The", "incidence", "of", "grade", "3", "or", "4", "adverse", "events", "were", "similar", "(", "78", "%", "v", "72", "%", ")", ",", "although", "a", "higher", "incidence", "of", "hand", "-", "foot", "syndrome", "(", "24", "%", "v", "0", "%", ")", "and", "mucositis", "/", "stomatitis", "(", "12", "%", "v", "1", "%", ")", "were", "observed", "in", "the", "PLD", "-", "docetaxel", "combination", ".", "Protocol", "-", "defined", "left", "ventricular", "ejection", "fraction", "decreases", "and", "congestive", "heart", "failure", "were", "reported", "in", "5", "%", "and", "1", "%", "in", "both", "treatment", "arms", ",", "respectively", ".", "The", "PLD", "-", "docetaxel", "combination", "was", "more", "effective", "than", "docetaxel", "alone", "in", "women", "with", "metastatic", "breast", "cancer", "who", "had", "experienced", "relapse", "at", "least", "1", "year", "after", "prior", "adjuvant", "anthracycline", "therapy", "without", "an", "increase", "in", "cardiac", "toxicity", ",", "although", "mucocutaneous", "toxicity", "was", "more", "common", "." ]

[ 17, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 19, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 0, 23, 24, 24, 24, 24, 24, 0, 23, 24, 0, 0, 23, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 39, 0, 37, 38, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 31, 32, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 29, 30, 0, 31, 32, 0, 0, 21, 22, 22, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Initial", "impact", "of", "tailored", "web", "-", "based", "messages", "about", "cigarette", "smoke", "and", "breast", "cancer", "risk", "on", "boys", "'", "and", "girls", "'", "risk", "perceptions", "and", "information", "seeking", ":", "randomized", "controlled", "trial", ".", "Recent", "evidence", "indicates", "a", "causal", "link", "between", "both", "active", "smoking", "and", "secondhand", "smoke", "(", "SHS", ")", "exposure", "and", "breast", "cancer", "(", "BC", ")", ".", "The", "objective", "of", "the", "present", "study", "was", "to", "evaluate", "the", "initial", "reactions", "of", "girls", "and", "boys", "to", "tailored", "Web", "-", "based", "messages", "that", "describe", "the", "relationship", "between", "SHS", "and", "BC", ",", "using", "a", "parallel", ",", "single", "-", "blinded", "cluster", "randomized", "controlled", "trial", ".", "This", "trial", "was", "nested", "within", "a", "cycle", "of", "an", "ongoing", "longitudinal", "study", "of", "1498", "students", "from", "74", "secondary", "schools", ".", "Self", "-", "reported", "assessments", "were", "used", "to", "evaluate", "the", "impact", "of", "study", "messages", "on", "participants", "'", "risk", "perception", "and", "interest", "in", "obtaining", "additional", "information", "after", "participants", "were", "randomized", "by", "schools", "to", "control", "or", "intervention", "groups", ".", "The", "intervention", "group", "received", "a", "tailored", "visual", "message", "(", "based", "on", "gender", "and", "Aboriginal", "status", ")", "about", "BC", "and", "tobacco", "smoke", ".", "The", "control", "group", "received", "a", "standard", "visual", "message", "about", "smoking", "and", "cancer", ".", "SHS", "exposure", "was", "identified", "as", "a", "BC", "risk", "factor", "by", "380", "/", "1488", "(", "25.54", "%", ")", "participants", ",", "during", "the", "preintervention", "analysis", ".", "Compared", "to", "the", "female", "participants", "in", "the", "control", "group", "(", "491", "/", "839", ",", "58.5", "%", ")", ",", "girls", "who", "received", "the", "intervention", "(", "339", "/", "649", ",", "52.2", "%", ")", "were", "14", "%", "more", "likely", "to", "agree", "that", "exposure", "to", "SHS", "increased", "their", "BC", "risk", "(", "relative", "risk", "[", "RR", "]", "1.14", ",", "95", "%", "CI", "1.07", "-", "1.21", ")", ".", "Nonsmoking", "girls", "who", "received", "the", "intervention", "were", "14", "%", "more", "likely", "to", "agree", "that", "starting", "smoking", "would", "increase", "their", "BC", "risk", "(", "RR", "1.14", ",", "95", "%", "CI", "1.07", "-", "1.21", ")", ".", "Compared", "to", "the", "male", "participants", "in", "control", "group", "(", "348", "/", "839", ",", "41.5", "%", ")", ",", "boys", "who", "received", "the", "intervention", "(", "310", "/", "649", ",", "47.8", "%", ")", "were", "10", "%", "more", "likely", "to", "agree", "that", "girls", "'", "exposure", "to", "SHS", "increased", "their", "BC", "risk", "(", "RR", "1.10", ",", "95", "%", "CI", "1.02", "-", "1.18", ")", ".", "Compared", "to", "controls", ",", "girls", "who", "received", "the", "intervention", "were", "52", "%", "more", "likely", "to", "request", "additional", "information", "about", "SHS", "and", "BC", "(", "RR", "1.52", ",", "95", "%", "CI", "1.12", "-", "2.06", ")", ".", "Brief", "gender", "-", "sensitive", "messages", "delivered", "via", "the", "Internet", "have", "the", "potential", "to", "increase", "awareness", "and", "to", "stimulate", "information", "seeking", "about", "the", "risk", "for", "BC", "associated", "with", "SHS", "." ]

[ 0, 0, 0, 17, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 27, 0, 5, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 25, 0, 3, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 27, 0, 5, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 25, 0, 3, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "5", "-year", "follow", "-", "up", "of", "a", "randomized", "controlled", "trial", "of", "immediate", "versus", "delayed", "zoledronic", "acid", "for", "the", "prevention", "of", "bone", "loss", "in", "postmenopausal", "women", "with", "breast", "cancer", "starting", "letrozole", "after", "tamoxifen", ":", "N", "03", "CC", "(", "Alliance", ")", "trial", ".", "Postmenopausal", "women", "with", "breast", "cancer", "receiving", "aromatase", "inhibitors", "are", "at", "an", "increased", "risk", "of", "bone", "loss", ".", "The", "current", "study", "was", "undertaken", "to", "determine", "whether", "upfront", "versus", "delayed", "treatment", "with", "zoledronic", "acid", "(", "ZA", ")", "impacted", "bone", "loss", ".", "This", "report", "described", "the", "5", "-year", "follow", "-", "up", "results", ".", "A", "total", "of", "551", "postmenopausal", "women", "with", "breast", "cancer", "who", "completed", "tamoxifen", "treatment", "and", "were", "undergoing", "daily", "letrozole", "treatment", "were", "randomized", "to", "either", "upfront", "(", "274", "patients", ")", "or", "delayed", "(", "277", "patients", ")", "ZA", "at", "a", "dose", "of", "4", "mg", "intravenously", "every", "6", "months", ".", "In", "the", "patients", "on", "the", "delayed", "treatment", "arm", ",", "ZA", "was", "initiated", "for", "a", "postbaseline", "bone", "mineral", "density", "T", "-", "score", "of", "<", "-", "2.0", "or", "fracture", ".", "The", "incidence", "of", "a", "5", "%", "decrease", "in", "the", "total", "lumbar", "spine", "bone", "mineral", "density", "at", "5", "years", "was", "10.2", "%", "in", "the", "upfront", "treatment", "arm", "versus", "41.2", "%", "in", "the", "delayed", "treatment", "arm", "(", "P", "<", ".", "0001", ")", ".", "A", "total", "of", "41", "patients", "in", "the", "delayed", "treatment", "arm", "were", "eventually", "started", "on", "ZA", ".", "With", "the", "exception", "of", "increased", "NCI", "Common", "Toxicity", "Criteria", "(", "CTC", ")", "grade", "1", "/", "2", "elevated", "creatinine", "and", "fever", "in", "the", "patients", "treated", "on", "the", "upfront", "arm", "and", "cerebrovascular", "ischemia", "among", "those", "in", "the", "delayed", "treatment", "arm", ",", "there", "were", "no", "significant", "differences", "observed", "between", "arms", "with", "respect", "to", "the", "most", "common", "adverse", "events", "of", "arthralgia", "and", "back", "pain", ".", "Osteoporosis", "occurred", "less", "frequently", "in", "the", "upfront", "treatment", "arm", "(", "2", "vs", "8", "cumulative", "cases", ")", ",", "although", "this", "difference", "was", "not", "found", "to", "be", "statistically", "significant", ".", "Bone", "fractures", "occurred", "in", "24", "patients", "in", "the", "upfront", "treatment", "arm", "versus", "25", "patients", "in", "the", "delayed", "treatment", "arm", ".", "Immediate", "treatment", "with", "ZA", "prevented", "bone", "loss", "compared", "with", "delayed", "treatment", "in", "postmenopausal", "women", "receiving", "letrozole", "and", "these", "differences", "were", "maintained", "at", "5", "years", ".", "The", "incidence", "of", "osteoporosis", "or", "fractures", "was", "not", "found", "to", "be", "significantly", "different", "between", "treatment", "arms", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 0, 0, 0, 0, 13, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 19, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 0, 29, 30, 0, 0, 0, 0, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 21, 22, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 25, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 25, 0, 0, 0, 0, 0, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Oral", "ibandronate", "reduces", "the", "risk", "of", "skeletal", "complications", "in", "breast", "cancer", "patients", "with", "metastatic", "bone", "disease", ":", "results", "from", "two", "randomised", ",", "placebo", "-", "controlled", "phase", "III", "studies", ".", "Although", "intravenous", "(", "i.", "v.", ")", "bisphosphonates", "are", "the", "standard", "of", "care", "for", "metastatic", "bone", "disease", ",", "they", "are", "less", "than", "ideal", "for", "many", "patients", "due", "to", "infusion", "-", "related", "adverse", "events", "(", "AEs", ")", ",", "an", "increased", "risk", "of", "renal", "toxicity", "and", "the", "inconvenience", "of", "regular", "hospital", "visits", ".", "The", "use", "of", "oral", "bisphosphonate", "therapy", "is", "limited", "by", "concerns", "over", "efficacy", "and", "gastrointestinal", "(", "GI", ")", "side", "effects", ".", "There", "remains", "a", "clinical", "need", "for", "an", "oral", "bisphosphonate", "that", "offers", "equivalent", "efficacy", "to", "i.", "v.", "bisphosphonates", ",", "good", "tolerability", "and", "dosing", "convenience", ".", "Oral", "ibandronate", ",", "a", "highly", "potent", ",", "third", "-", "generation", "aminobisphosphonate", ",", "has", "been", "evaluated", "in", "phase", "III", "clinical", "trials", "of", "patients", "with", "bone", "metastases", "from", "breast", "cancer", ".", "In", "two", "pooled", "phase", "III", "studies", ",", "patients", "with", "breast", "cancer", "and", "bone", "metastases", "were", "randomised", "to", "receive", "oral", "ibandronate", "50", "mg", "(", "n=", "287", ")", "or", "placebo", "(", "n=", "277", ")", "once", "daily", "for", "up", "to", "96", "weeks", ".", "The", "primary", "end", "point", "was", "the", "skeletal", "morbidity", "period", "rate", "(", "SMPR", ")", ",", "defined", "as", "the", "number", "of", "12", "-week", "periods", "with", "new", "skeletal", "complications", ".", "Multivariate", "Poisson", "'s", "regression", "analysis", "was", "used", "to", "assess", "the", "relative", "risk", "of", "skeletal", "-", "related", "events", "in", "each", "treatment", "group", "during", "the", "study", "period", ".", "Oral", "ibandronate", "50", "mg", "significantly", "reduced", "the", "mean", "SMPR", "compared", "with", "placebo", "(", "0.95", "vs", "1.18", ",", "P=", "0.004", ")", ".", "There", "was", "a", "significant", "reduction", "in", "the", "mean", "number", "of", "events", "requiring", "radiotherapy", "(", "0.73", "vs", "0.98", ",", "P", "<", "0.001", ")", "and", "events", "requiring", "surgery", "(", "0.47", "vs", "0.53", ",", "P=", "0.037", ")", ".", "Poisson", "'s", "regression", "analysis", "confirmed", "that", "oral", "ibandronate", "significantly", "reduced", "the", "risk", "of", "a", "skeletal", "event", "compared", "with", "placebo", "(", "hazard", "ratio", "0.62", ",", "95", "%", "CI=", "0.48", ",", "0.79", ";", "P=", "0.0001", ")", ".", "The", "incidence", "of", "mild", "treatment", "-", "related", "upper", "GI", "AEs", "was", "slightly", "higher", "in", "the", "oral", "ibandronate", "50", "mg", "group", "compared", "with", "placebo", ",", "but", "very", "few", "serious", "drug", "-", "related", "AEs", "were", "reported", ".", "Oral", "ibandronate", "50", "mg", "is", "an", "effective", ",", "well", "-", "tolerated", "and", "convenient", "treatment", "for", "the", "prevention", "of", "skeletal", "complications", "of", "metastatic", "bone", "disease", "." ]

[ 17, 18, 0, 0, 0, 0, 13, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 19, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 33, 0, 35, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 33, 0, 35, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 33, 0, 35, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "First", "-", "line", "treatment", "of", "advanced", "breast", "cancer", "with", "sunitinib", "in", "combination", "with", "docetaxel", "versus", "docetaxel", "alone", ":", "results", "of", "a", "prospective", ",", "randomized", "phase", "III", "study", ".", "To", "investigate", "whether", "sunitinib", "plus", "docetaxel", "improves", "clinical", "outcomes", "for", "patients", "with", "human", "epidermal", "growth", "factor", "receptor", "2", "(", "HER", "2", ")", "/", "neu", "-", "negative", "advanced", "breast", "cancer", "(", "ABC", ")", "versus", "docetaxel", "alone", ".", "In", "this", "phase", "III", "study", ",", "patients", "were", "randomly", "assigned", "to", "open", "-", "label", "combination", "therapy", "(", "sunitinib", "37.5", "mg", "/", "d", ",", "days", "2", "to", "15", "every", "3", "weeks", ";", "and", "docetaxel", "75", "mg", "/", "m", "(", "2", ")", ",", "day", "1", "every", "3", "weeks", ")", "or", "monotherapy", "(", "docetaxel", "100", "mg", "/", "m", "(", "2", ")", "every", "3", "weeks", ")", ".", "Progression", "-", "free", "survival", "(", "PFS", ")", "was", "the", "primary", "end", "point", ".", "Two", "hundred", "ninety", "-", "six", "patients", "were", "randomly", "assigned", "to", "combination", "therapy", ",", "and", "297", "patients", "were", "assigned", "to", "monotherapy", ".", "Median", "PFS", "times", "were", "8.6", "and", "8.3", "months", "with", "combination", "therapy", "and", "monotherapy", ",", "respectively", "(", "hazard", "ratio", ",", "0.92", ";", "one", "-", "sided", "P", "=", ".", "265", ")", ".", "The", "objective", "response", "rate", "(", "ORR", ")", "was", "significantly", "higher", "with", "the", "combination", "(", "55", "%", ")", "than", "with", "monotherapy", "(", "42", "%", ";", "one", "-", "sided", "P", "=", ".", "001", ")", ".", "Duration", "of", "response", "was", "similar", "in", "both", "arms", "(", "7.5", "months", "with", "the", "combination", "v", "7.2", "months", "with", "monotherapy", ")", ".", "Median", "overall", "survival", "(", "OS", ")", "times", "were", "24.8", "and", "25.5", "months", "with", "combination", "therapy", "and", "monotherapy", ",", "respectively", "(", "one", "-", "sided", "P", "=", ".", "904", ")", ".", "There", "were", "107", "deaths", "with", "the", "combination", "and", "91", "deaths", "with", "monotherapy", ".", "The", "frequency", "of", "common", "adverse", "events", "(", "AEs", ")", "was", "higher", "with", "the", "combination", ",", "as", "were", "treatment", "discontinuations", "caused", "by", "AEs", ".", "The", "combination", "of", "sunitinib", "plus", "docetaxel", "improved", "ORR", "but", "did", "not", "prolong", "either", "PFS", "or", "OS", "compared", "with", "docetaxel", "alone", "when", "given", "to", "an", "unselected", "HER", "2", "/", "neu", "-", "negative", "cohort", "as", "first", "-", "line", "treatment", "for", "ABC", ".", "Sunitinib", "combination", "therapy", "may", "also", "have", "resulted", "in", "AEs", "that", "yield", "an", "unfavorable", "risk", "-", "benefit", "ratio", ".", "The", "sunitinib", "-", "docetaxel", "regimen", "evaluated", "in", "this", "study", "is", "not", "recommended", "for", "further", "use", "in", "ABC", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 18, 18, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 3, 4, 4, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 37, 0, 39, 40, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 0, 0, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 37, 38, 0, 0, 0, 0, 39, 40, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 37, 0, 39, 40, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 25, 21, 0, 0, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Informed", "choice", "about", "breast", "cancer", "prevention", ":", "randomized", "controlled", "trial", "of", "an", "online", "decision", "aid", "intervention", ".", "Tamoxifen", "and", "raloxifene", "are", "chemopreventive", "drugs", "that", "can", "reduce", "women", "’s", "relative", "risk", "of", "primary", "breast", "cancer", "by", "50", "%", ";", "however", ",", "most", "women", "eligible", "for", "these", "drugs", "have", "chosen", "not", "to", "take", "them", ".", "The", "reasons", "for", "low", "uptake", "may", "be", "related", "to", "women", "’s", "knowledge", "or", "attitudes", "towards", "the", "drugs", ".", "We", "aimed", "to", "examine", "the", "impact", "of", "an", "online", "breast", "cancer", "chemoprevention", "decision", "aid", "(", "DA", ")", "on", "informed", "intentions", "and", "decisions", "of", "women", "at", "high", "risk", "of", "breast", "cancer", ".", "We", "conducted", "a", "randomized", "clinical", "trial", ",", "assessing", "the", "effect", "of", "a", "DA", "about", "breast", "cancer", "chemoprevention", "on", "informed", "choices", "about", "chemoprevention", ".", "Women", "(", "n", "=", "585", ")", ",", "46", "-", "to", "74", "-years", "old", "old", ",", "completed", "online", "baseline", ",", "post", "-", "test", ",", "and", "three", "-", "month", "follow", "-", "up", "questionnaires", ".", "Participants", "were", "randomly", "assigned", "to", "either", "an", "intervention", "group", ",", "a", "standard", "control", "group", "that", "answered", "questions", "about", "chemoprevention", "at", "baseline", ",", "or", "a", "three", "-", "month", "control", "group", "that", "did", "not", "answer", "questions", "about", "chemoprevention", "at", "baseline", ".", "The", "main", "outcome", "measures", "were", "whether", "women", "’s", "intentions", "and", "decisions", "regarding", "chemoprevention", "drugs", "were", "informed", ",", "and", "whether", "women", "who", "viewed", "the", "DA", "were", "more", "likely", "to", "make", "informed", "decisions", "than", "women", "who", "did", "not", "view", "the", "DA", ",", "using", "a", "dichotomous", "composite", "variable", "‘", "informed", "choice", "’", "(", "yes", "/", "no", ")", "to", "classify", "informed", "decisions", "as", "those", "reflecting", "sufficient", "knowledge", "and", "concordance", "between", "a", "woman", "’s", "decision", "and", "relevant", "attitudes", ".", "Analyses", "showed", "that", "more", "intervention", "than", "standard", "control", "participants", "(", "52.7", "%", "versus", "5.9", "%", ")", "made", "informed", "decisions", "at", "post", "-", "test", ",", "P", "<", "0.001", ".", "At", "the", "three", "-", "month", "follow", "-", "up", ",", "differences", "in", "rates", "of", "informed", "choice", "between", "intervention", "(", "16.9", "%", ")", "and", "both", "control", "groups", "(", "11.8", "%", "and", "8.0", "%", ")", "were", "statistically", "non", "-", "significant", ",", "P", "=", "0.067", ".", "The", "DA", "increased", "informed", "decision", "making", "about", "breast", "cancer", "chemoprevention", ",", "although", "the", "impact", "on", "knowledge", "diminished", "over", "time", ".", "This", "study", "was", "not", "designed", "to", "determine", "how", "much", "knowledge", "decision", "makers", "must", "retain", "over", "time", ".", "Examining", "informed", "decisions", "increases", "understanding", "of", "the", "impact", "of", "DAs", ".", "A", "standard", "for", "defining", "and", "measuring", "sufficient", "knowledge", "for", "informed", "decisions", "is", "needed", ".", "ClinicalTrials.gov", ":", "NCT", "00967824" ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 18, 18, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 7, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 20, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 31, 32, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 29, 30, 0, 0, 0, 0, 0, 0, 31, 32, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Cosmetic", "outcome", "and", "surgical", "site", "infection", "rates", "of", "antibacterial", "absorbable", "(", "Polyglactin", "910", ")", "suture", "compared", "to", "Chinese", "silk", "suture", "in", "breast", "cancer", "surgery", ":", "a", "randomized", "pilot", "research", ".", "The", "primary", "objective", "of", "this", "multicenter", "post", "-", "market", "study", "was", "to", "compare", "the", "cosmetic", "outcome", "of", "triclosan", "-", "coated", "VICRYL", "Plus", "sutures", "with", "Chinese", "silk", "sutures", "for", "skin", "closure", "of", "modified", "radical", "mastectomy", ".", "A", "secondary", "objective", "was", "to", "assess", "the", "incidence", "of", "surgical", "site", "infection", "(", "SSI", ")", ".", "Patients", "undergoing", "modified", "radical", "mastectomy", "were", "randomly", "assigned", "to", "coated", "VICRYL", "Plus", "antibacterial", "(", "Polyglactin", "910", ")", "suture", "or", "Chinese", "silk", "suture", ".", "Cosmetic", "outcomes", "were", "evaluated", "postoperatively", "at", "days", "12", "(", "±", "2", ")", "and", "30", "(", "±", "5", ")", ",", "and", "the", "evidence", "of", "SSI", "was", "assessed", "at", "days", "3", ",", "5", ",", "7", ",", "12", "(", "±", "2", ")", ",", "30", "(", "±", "5", ")", ",", "and", "90", "(", "±", "7", ")", ".", "Cosmetic", "outcomes", "were", "independently", "assessed", "via", "visual", "analogue", "scale", "(", "VAS", ")", "score", "evaluations", "of", "blinded", "incision", "photographs", "(", "primary", "endpoint", ")", "and", "surgeon", "-", "assessed", "modified", "Hollander", "Scale", "(", "mHCS", ")", "scores", "(", "secondary", "endpoint", ")", ".", "SSI", "assessments", "used", "both", "CDC", "criteria", "and", "ASEPSIS", "scores", ".", "Six", "Chinese", "hospitals", "randomized", "101", "women", "undergoing", "modified", "radical", "mastectomy", "to", "closure", "with", "coated", "VICRYL", "Plus", "suture", "(", "n", "=", "51", ")", "or", "Chinese", "silk", "suture", "(", "n", "=", "50", ")", ".", "Mean", "VAS", "cosmetic", "outcome", "scores", "for", "antibacterial", "suture", "(", "67.2", ")", "were", "better", "than", "for", "Chinese", "silk", "(", "45.4", ")", "at", "day", "30", "(", "P", "<", "0.0001", ")", ")", ".", "Mean", "mHCS", "cosmetic", "outcome", "total", "scores", ",", "were", "also", "higher", "for", "antibacterial", "suture", "(", "5.7", ")", "than", "for", "Chinese", "silk", "(", "5.0", ")", "at", "day", "30", "(", "P", "=", "0.002", ")", ".", "Patients", "using", "coated", "VICRYL", "Plus", "suture", "had", "significantly", "better", "cosmetic", "outcomes", "than", "those", "with", "Chinese", "silk", "sutures", ".", "Patients", "using", "coated", "VICRYL", "Plus", "suture", "had", "a", "lower", "SSI", "incidence", "compared", "to", "the", "Chinese", "silk", "sutures", ",", "although", "the", "difference", "did", "not", "reach", "statistical", "significance", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 18, 18, 18, 18, 0, 0, 19, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 33, 0, 0, 0, 0, 0, 0, 0, 0, 35, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 33, 0, 0, 0, 0, 0, 0, 35, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Uptake", "of", "tamoxifen", "in", "consecutive", "premenopausal", "women", "under", "surveillance", "in", "a", "high", "-", "risk", "breast", "cancer", "clinic", ".", "Randomised", "trials", "of", "tamoxifen", "versus", "placebo", "indicate", "that", "tamoxifen", "reduces", "breast", "cancer", "risk", "by", "approximately", "33", "%", ",", "yet", "uptake", "is", "low", ".", "Approximately", "10", "%", "of", "women", "in", "our", "clinic", "entered", "the", "IBIS", "-", "I", "prevention", "trial", ".", "We", "assess", "the", "uptake", "of", "tamoxifen", "in", "a", "consecutive", "series", "of", "premenopausal", "women", "not", "in", "a", "trial", "and", "explore", "the", "reasons", "for", "uptake", "through", "interviews", ".", "All", "eligible", "women", "between", "33", "and", "46", "years", "at", "≥", "17", "%", "lifetime", "risk", "of", "breast", "cancer", "and", "undergoing", "annual", "mammography", "in", "our", "service", "were", "invited", "to", "take", "a", "5", "-year", "course", "of", "tamoxifen", ".", "Reasons", "for", "accepting", "(", "n=", "15", ")", "or", "declining", "(", "n=", "15", ")", "were", "explored", "using", "semi", "-", "structured", "interviews", ".", "Of", "1279", "eligible", "women", ",", "136", "(", "10.6", "%", ")", "decided", "to", "take", "tamoxifen", ".", "Women", ">", "40", "years", "(", "74", "out", "of", "553", "(", "13.4", "%", ")", ")", "and", "those", "at", "higher", "non", "-", "BRCA", "-", "associated", "risk", "were", "more", "likely", "to", "accept", "tamoxifen", "(", "129", "out", "of", "1109", "(", "11.6", "%", ")", ")", ".", "Interviews", "highlighted", "four", "themes", "surrounding", "decision", "making", ":", "perceived", "impact", "of", "side", "effects", ",", "the", "impact", "of", "others", "'", "experience", "on", "beliefs", "about", "tamoxifen", ",", "tamoxifen", "as", "a", "'", "cancer", "drug", "'", ",", "and", "daily", "reminder", "of", "cancer", "risk", ".", "Tamoxifen", "uptake", "was", "similar", "to", "previously", "ascertained", "uptake", "in", "a", "randomised", "controlled", "trial", "(", "IBIS", "-", "I", ")", ".", "Concerns", "were", "similar", "in", "women", "who", "did", "or", "did", "not", "accept", "tamoxifen", ".", "Decision", "making", "appeared", "to", "be", "embedded", "in", "the", "experience", "of", "significant", "others", "." ]

[ 0, 0, 17, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 25, 0, 29, 30, 0, 21, 22, 22, 22, 0, 21, 22, 22, 22, 0, 25, 0, 0, 3, 0, 29, 30, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 0, 21, 22, 22, 22, 22, 0, 25, 0, 0, 3, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Accelerated", "partial", "breast", "irradiation", "using", "intensity", "-", "modulated", "radiotherapy", "technique", "compared", "to", "whole", "breast", "irradiation", "for", "patients", "aged", "70", "years", "or", "older", ":", "subgroup", "analysis", "from", "a", "randomized", "phase", "3", "trial", ".", "The", "purpose", "of", "this", "study", "was", "to", "report", "the", "efficacy", "and", "the", "safety", "profile", "on", "the", "subset", "of", "selected", "early", "breast", "cancer", "(", "BC", ")", "patients", "aged", "70", "years", "or", "older", "from", "a", "single", "-", "center", "phase", "3", "trial", "comparing", "whole", "breast", "irradiation", "(", "WBI", ")", "to", "accelerated", "partial", "breast", "irradiation", "(", "APBI", ")", "using", "intensity", "-", "modulated", "radiation", "therapy", "technique", ".", "Between", "2005", "and", "2013", ",", "520", "patients", "aged", "more", "than", "40", "years", "old", "were", "enrolled", "and", "randomly", "assigned", "to", "receive", "either", "WBI", "or", "APBI", "in", "a", "1", ":1", "ratio", ".", "Eligible", "patients", "were", "women", "with", "early", "BC", "(", "maximum", "diameter", "2.5", "cm", ")", "suitable", "for", "breast", "conserving", "surgery", ".", "This", "study", "is", "registered", "with", "ClinicalTrials.gov", ",", "NCT", "02104895", ".", "A", "total", "of", "117", "patients", "aged", "70", "years", "or", "more", "were", "analyzed", "(", "58", "in", "the", "WBI", "arm", ",", "59", "in", "the", "APBI", "arm", ")", ".", "At", "a", "median", "follow", "-", "up", "of", "5", "-years", "(", "range", "3.4", "-", "7.0", ")", ",", "the", "ipsilateral", "breast", "tumor", "recurrence", "(", "IBTR", ")", "rate", "was", "1.9", "%", "in", "both", "groups", ".", "No", "significant", "difference", "between", "the", "two", "groups", "was", "identified", "(", "log", "-", "rank", "test", "p", "=", "0.96", ")", ".", "The", "5", "-year", "disease", "-", "free", "survival", "(", "DFS", ")", "rates", "in", "the", "WBI", "group", "and", "APBI", "group", "were", "6.1", "and", "1.9", "%", ",", "respectively", "(", "p", "=", "0.33", ")", ".", "The", "APBI", "group", "presented", "significantly", "better", "results", "in", "terms", "of", "acute", "skin", "toxicity", ",", "considering", "both", "any", "grade", "(", "p", "=", "0.0001", ")", "and", "grade", "2", "or", "higher", "(", "p", "=", "0.0001", ")", ".", "Our", "subgroup", "analyses", "showed", "a", "very", "low", "rate", "and", "no", "significant", "difference", "in", "terms", "of", "IBTR", ",", "using", "both", "WBI", "and", "APBI", ".", "A", "significant", "impact", "on", "patients", "compliance", "in", "terms", "of", "acute", "and", "early", "late", "toxicity", "was", "shown", ",", "which", "could", "translate", "in", "a", "consistent", "improvement", "of", "overall", "quality", "of", "life", "." ]

[ 17, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 7, 8, 8, 8, 8, 0, 0, 0, 5, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 31, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "randomized", "phase", "II", "trial", "investigating", "the", "effect", "of", "platelet", "function", "inhibition", "on", "circulating", "tumor", "cells", "in", "patients", "with", "metastatic", "breast", "cancer", ".", "Blockade", "of", "platelet", "activation", "and", "aggregation", "can", "inhibit", "metastasis", "in", "preclinical", "models", "and", "is", "associated", "with", "cancer", "prevention", ".", "To", "test", "whether", "disruption", "of", "platelet", "function", "with", "clopidogrel", "and", "aspirin", "would", "decrease", "the", "number", "of", "circulating", "tumor", "cells", "(", "CTCs", ")", "in", "patients", "with", "metastatic", "breast", "cancer", ",", "a", "randomized", "phase", "II", "study", "was", "performed", ".", "Patients", "with", "metastatic", "breast", "cancer", "who", "were", "not", "currently", "receiving", "cytotoxic", "chemotherapy", "were", "eligible", ".", "Patients", "were", "randomized", "to", "receive", "either", "clopidogrel", "and", "aspirin", "or", "to", "a", "control", "group", "receiving", "no", "treatment", ".", "Phlebotomy", "was", "performed", "at", "baseline", ",", "at", "2", "and", "4", "weeks", ",", "and", "monthly", "thereafter", "to", "obtain", "specimens", "to", "assess", "CTC", ",", "platelet", "aggregation", ",", "and", "thrombin", "activity", ".", "The", "primary", "end", "point", "was", "the", "proportion", "of", "patients", "with", "detectable", "CTCs", "at", "1", "month", ".", "Forty", "-", "eight", "patients", "were", "enrolled", "and", "42", "were", "evaluable", "at", "1", "month", ".", "Baseline", "CTC", "numbers", "were", "≥", "5", "in", "13", "%", "and", "≥", "1", "in", "65", "%", "of", "patients", ".", "Despite", "adequate", "platelet", "function", "inhibition", "in", "the", "treatment", "group", ",", "the", "proportion", "of", "patients", "with", "detectable", "CTCs", "was", "similar", "between", "the", "clopidogrel", "/", "aspirin", "and", "control", "groups", "at", "baseline", "(", "P", "=", ".", "21", ")", "and", "4", "weeks", "(", "P", "=", ".", "75", ")", ",", "showing", "no", "treatment", "effect", ".", "Measured", "endogenous", "thrombin", "potential", "did", "not", "correlate", "with", "CTC", "number", ".", "No", "bleeding", "-", "related", "serious", "adverse", "events", "(", "SAEs", ")", "occurred", ".", "The", "baseline", "CTC", "numbers", "were", "lower", "than", "expected", ",", "decreasing", "the", "ability", "to", "detect", "an", "impact", "of", "platelet", "inhibition", "on", "CTCs", ".", "Clopidogrel", "and", "aspirin", "were", "well", "tolerated", ".", "Future", "studies", "evaluating", "the", "potential", "therapeutic", "role", "of", "antiplatelet", "therapy", "in", "breast", "cancer", "remain", "of", "interest", ",", "and", "they", "may", "be", "informed", "by", "these", "results", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Effect", "of", "myofascial", "techniques", "for", "treatment", "of", "persistent", "arm", "pain", "after", "breast", "cancer", "treatment", ":", "randomized", "controlled", "trial", ".", "To", "investigate", "the", "effect", "of", "myofascial", "therapy", "in", "addition", "to", "a", "standard", "physical", "therapy", "program", "for", "treatment", "of", "persistent", "arm", "pain", "after", "finishing", "breast", "cancer", "treatment", ".", "Double", "-", "blinded", "(", "patient", "and", "assessor", ")", "randomized", "controlled", "trial", ".", "University", "Hospitals", "Leuven", ",", "Belgium", ".", "A", "total", "of", "50", "patients", "with", "persistent", "arm", "pain", "and", "myofascial", "dysfunctions", "after", "breast", "cancer", "treatment", ".", "Over", "three", "months", ",", "all", "patients", "received", "a", "standard", "physical", "therapy", "program", ".", "The", "intervention", "group", "received", "in", "addition", "12", "sessions", "of", "myofascial", "therapy", ",", "and", "the", "control", "group", "received", "12", "sessions", "of", "placebo", "therapy", ".", "Main", "outcome", "parameters", "were", "pain", "intensity", "(", "primary", "outcome", ")", "(", "maximum", "visual", "analogue", "scale", "(", "VAS", ")", "(", "0", "-", "100", ")", ")", ",", "prevalence", "rate", "of", "arm", "pain", ",", "pressure", "hypersensitivity", "(", "pressure", "pain", "thresholds", "(", "kg", "/", "cm", "2", ")", "and", "pain", "quality", "(", "McGill", "Pain", "Questionnaire", ")", ".", "Measures", "were", "taken", "before", "and", "after", "the", "intervention", "and", "at", "long", "term", "(", "6", "and", "12", "months", "follow", "-", "up", ")", ".", "Patients", "in", "the", "intervention", "group", "had", "a", "significantly", "greater", "decrease", "in", "pain", "intensity", "compared", "to", "the", "control", "group", "(", "VAS", "-", "44", "/", "100", "vs.", "-", "24", "/", "100", ",", "P", "=", "0.046", ")", "with", "a", "mean", "difference", "in", "change", "after", "three", "months", "between", "groups", "of", "20", "/", "100", "(", "95", "%", "confidence", "interval", ",", "0.4", "to", "39.7", ")", ".", "After", "the", "intervention", ",", "44", "%", "versus", "64", "%", "of", "patients", "still", "experienced", "pain", "in", "the", "intervention", "and", "control", "group", ",", "respectively", "(", "P", "=", "0.246", ")", ".", "No", "significant", "differences", "were", "found", "for", "the", "other", "outcomes", ".", "Myofascial", "therapy", "is", "an", "effective", "physical", "therapy", "modality", "to", "decrease", "pain", "intensity", "at", "the", "arm", "in", "breast", "cancer", "survivors", "at", "three", "months", ",", "but", "no", "other", "benefits", "at", "that", "time", "were", "found", ".", "There", "were", "no", "long", "-", "term", "effects", "at", "12", "months", "either", "." ]

[ 0, 0, 17, 18, 0, 0, 0, 13, 14, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 0, 0, 0, 0, 1, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 0, 0, 0, 0, 0, 23, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 0, 23, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 31, 32, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Primary", "analysis", "of", "a", "prospective", ",", "randomized", ",", "single", "-", "blinded", "phase", "II", "trial", "evaluating", "the", "HER", "2", "peptide", "AE", "37", "vaccine", "in", "breast", "cancer", "patients", "to", "prevent", "recurrence", ".", "AE", "37", "is", "the", "Ii", "-", "Key", "hybrid", "of", "the", "MHC", "class", "II", "peptide", ",", "AE", "36", "(", "HER", "2", "aa:", "776", "-", "790", ")", ".", "Phase", "I", "studies", "showed", "AE", "37", "administered", "with", "granulocyte", "macrophage", "colony", "-", "stimulating", "factor", "(", "GM", "-", "CSF", ")", "to", "be", "safe", "and", "highly", "immunogenic", ".", "A", "prospective", ",", "randomized", ",", "multicenter", "phase", "II", "adjuvant", "trial", "was", "conducted", "to", "evaluate", "the", "vaccine", "'s", "efficacy", ".", "Clinically", "disease", "-", "free", "node", "-", "positive", "and", "high", "-", "risk", "node", "-", "negative", "breast", "cancer", "patients", "with", "tumors", "expressing", "any", "degree", "of", "HER", "2", "[", "immunohistochemistry", "(", "IHC", ")", "1", "-", "3", "+", "]", "were", "enrolled", ".", "Patients", "were", "randomized", "to", "AE", "37", "+", "GM", "-", "CSF", "versus", "GM", "-", "CSF", "alone", ".", "Toxicity", "was", "monitored", ".", "Clinical", "recurrences", "were", "documented", "and", "disease", "-", "free", "survival", "(", "DFS", ")", "analyzed", ".", "The", "trial", "enrolled", "298", "patients", ";", "153", "received", "AE", "37", "+", "GM", "-", "CSF", "and", "145", "received", "GM", "-", "CSF", "alone", ".", "The", "groups", "were", "well", "matched", "for", "clinicopathologic", "characteristics", ".", "Toxicities", "have", "been", "minimal", ".", "At", "the", "time", "of", "the", "primary", "analysis", ",", "the", "recurrence", "rate", "in", "the", "vaccinated", "group", "was", "12.4", "%", "versus", "13.8", "%", "in", "the", "control", "group", "[", "relative", "risk", "reduction", "12", "%", ",", "HR", "0.885", ",", "95", "%", "confidence", "interval", "(", "CI", ")", "0.472", "-", "1.659", ",", "P", "=", "0.70", "]", ".", "The", "Kaplan", "-", "Meier", "estimated", "5", "-year", "DFS", "rate", "was", "80.8", "%", "in", "vaccinated", "versus", "79.5", "%", "in", "control", "patients", ".", "In", "planned", "subset", "analyses", "of", "patients", "with", "IHC", "1", "+", "/", "2", "+", "HER", "2", "-", "expressing", "tumors", ",", "5", "-year", "DFS", "was", "77.2", "%", "in", "vaccinated", "patients", "(", "n", "=", "76", ")", "versus", "65.7", "%", "in", "control", "patients", "(", "n", "=", "78", ")", "(", "P", "=", "0.21", ")", ".", "In", "patients", "with", "triple", "-", "negative", "breast", "cancer", "(", "HER", "2", "IHC", "1", "+", "/", "2", "+", "and", "hormone", "receptor", "negative", ")", "DFS", "was", "77.7", "%", "in", "vaccinated", "patients", "(", "n", "=", "25", ")", "versus", "49.0", "%", "in", "control", "patients", "(", "n", "=", "25", ")", "(", "P", "=", "0.12", ")", ".", "The", "overall", "intention", "-", "to", "-", "treat", "analysis", "demonstrates", "no", "benefit", "to", "vaccination", ".", "However", ",", "the", "results", "confirm", "that", "the", "vaccine", "is", "safe", "and", "suggest", "that", "vaccination", "may", "have", "clinical", "benefit", "in", "patients", "with", "low", "HER", "2", "-", "expressing", "tumors", ",", "specifically", "TNBC", ".", "Further", "evaluation", "in", "a", "randomized", "trial", "enrolling", "TNBC", "patients", "is", "warranted", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 13, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 29, 30, 0, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 29, 30, 0, 0, 0, 0, 0, 0, 25, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 29, 30, 0, 0, 0, 0, 0, 0, 25, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Role", "of", "detection", "method", "in", "predicting", "breast", "cancer", "survival", ":", "analysis", "of", "randomized", "screening", "trials", ".", "Screening", "mammography", "detects", "breast", "cancers", "earlier", "than", "those", "detected", "symptomatically", ",", "and", "so", "mammographically", "detected", "breast", "cancers", "tend", "to", "have", "better", "prognoses", ".", "The", "so", "-", "called", "stage", "shift", "that", "results", "from", "screen", "detection", "is", "subject", "to", "lead", "-", "time", "and", "length", "biases", ",", "and", "so", "earlier", "detection", "may", "not", "translate", "into", "longer", "survival", ".", "We", "used", "data", "from", "three", "large", "breast", "cancer", "screening", "trials", "--", "Health", "Insurance", "Plan", "(", "HIP", ")", "of", "New", "York", "and", "two", "Canadian", "National", "Breast", "Cancer", "Screening", "Studies", "(", "CNBSS", ")", "--", "to", "investigate", "survival", "benefits", "of", "breast", "cancer", "screening", "beyond", "stage", "shift", ".", "We", "also", "address", "whether", "method", "of", "detection", "is", "an", "independent", "prognostic", "factor", "in", "breast", "cancer", ".", "The", "HIP", "trial", "randomly", "assigned", "approximately", "62", ",", "000", "women", "to", "screening", "and", "control", "groups", ".", "The", "two", "CNBSS", "trial", "cohorts", "CNBSS-", "1", "and", "CNBSS-", "2", "included", "a", "total", "of", "44", ",", "970", "women", "in", "the", "screening", "group", "and", "44", ",", "961", "in", "the", "control", "group", ".", "After", "adjusting", "for", "stage", "and", "other", "tumor", "characteristics", "in", "a", "Cox", "proportional", "hazards", "model", ",", "survival", "distributions", "were", "compared", "by", "method", "of", "breast", "cancer", "detection", "with", "both", "univariate", "and", "multivariable", "analyses", ".", "All", "P", "values", "are", "two", "-", "sided", ".", "Breast", "cancers", "detected", "by", "screening", "mammography", "had", "a", "shift", "in", "stage", "distribution", "to", "earlier", "stages", "(", "for", "HIP", ",", "P", "<", ".", "001", ";", "for", "CNBSS-", "1", ",", "P", "=", ".", "03", ";", "and", "for", "CNBSS-", "2", ",", "P", "<", ".", "001", ")", ".", "After", "adjusting", "for", "tumor", "size", ",", "lymph", "node", "status", ",", "and", "disease", "stage", "in", "a", "Cox", "proportional", "hazards", "model", ",", "method", "of", "detection", "was", "a", "statistically", "significant", "independent", "predictor", "of", "disease", "-", "specific", "survival", ".", "Patients", "with", "interval", "cancers", "had", "a", "53", "%", "(", "95", "%", "confidence", "interval", "[", "CI", "]", "=", "17", "%", "to", "100", "%", ")", "greater", "hazard", "of", "death", "from", "breast", "cancer", "than", "patients", "with", "screen", "-", "detected", "cancers", ",", "and", "patients", "with", "cancer", "in", "the", "control", "groups", "had", "a", "36", "%", "(", "95", "%", "CI", "=", "10", "%", "to", "68", "%", ")", "greater", "hazard", "of", "death", "than", "patients", "with", "screen", "-", "detected", "cancer", ".", "There", "was", "an", "apparent", "survival", "benefit", "beyond", "stage", "shift", "for", "patients", "with", "screen", "-", "detected", "breast", "cancers", "compared", "with", "patients", "with", "breast", "cancers", "detected", "otherwise", ".", "Method", "of", "detection", "appears", "to", "be", "an", "important", "prognostic", "factor", ",", "even", "after", "adjusting", "for", "known", "tumor", "characteristics", ".", "This", "finding", "suggests", "that", "clinical", "trialists", "should", "routinely", "collect", "information", "about", "method", "of", "detection", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 16, 0, 0, 15, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 17, 0, 19, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 5, 6, 6, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Technology-", "and", "Phone", "-", "Based", "Weight", "Loss", "Intervention", ":", "Pilot", "RCT", "in", "Women", "at", "Elevated", "Breast", "Cancer", "Risk", ".", "For", "women", "with", "an", "increased", "breast", "cancer", "risk", ",", "reducing", "excess", "weight", "and", "increasing", "physical", "activity", "are", "believed", "to", "be", "important", "approaches", "for", "reducing", "their", "risk", ".", "This", "study", "tested", "a", "weight", "loss", "intervention", "that", "combined", "commercially", "available", "technology", "-", "based", "self", "-", "monitoring", "tools", "with", "individualized", "phone", "calls", ".", "Women", "were", "randomized", "to", "a", "weight", "loss", "intervention", "arm", "(", "n=", "36", ")", "or", "a", "usual", "care", "arm", "(", "n=", "18", ")", ".", "Participants", "were", "women", "with", "a", "BMI", "≥", "27.5", "kg", "/", "m", "2", "and", "elevated", "breast", "cancer", "risk", "recruited", "from", "the", "mammography", "clinic", "at", "the", "Moores", "Cancer", "Center", "at", "the", "University", "of", "California", "San", "Diego", ".", "Intervention", "participants", "used", "the", "MyFitnessPal", "website", "and", "phone", "app", "to", "monitor", "diet", "and", "a", "Fitbit", "to", "monitor", "physical", "activity", ".", "Participants", "received", "12", "standardized", "coaching", "calls", "with", "trained", "counselors", "over", "6", "months", ".", "Usual", "care", "participants", "received", "the", "U.S", ".", "Dietary", "Guidelines", "for", "Americans", "at", "baseline", "and", "two", "brief", "calls", "over", "the", "6", "months", ".", "Weight", "and", "accelerometer", "-", "measured", "physical", "activity", "were", "assessed", "at", "baseline", "and", "6", "months", ".", "Data", "were", "collected", "in", "San", "Diego", ",", "CA", ",", "from", "2012", "to", "2014", "and", "analyzed", "in", "2015", ".", "Participants", "(", "n=", "54", ")", "had", "a", "mean", "age", "of", "59.5", "(", "SD=", "5.6", ")", "years", ",", "BMI", "of", "31.9", "(", "SD=", "3.5", ")", ",", "and", "a", "mean", "Gail", "Model", "score", "of", "2.5", "(", "SD=", "1.4", ")", ".", "At", "6", "months", ",", "intervention", "participants", "had", "lost", "significantly", "more", "weight", "(", "4.4", "kg", "vs", "0.8", "kg", ",", "p=", "0.004", ")", "and", "a", "greater", "percentage", "of", "starting", "weight", "(", "5.3", "%", "vs", "1.0", "%", ",", "p=", "0.005", ")", "than", "usual", "care", "participants", ".", "Across", "arms", ",", "greater", "increases", "in", "moderate", "-", "to", "-", "vigorous", "physical", "activity", "resulted", "in", "greater", "weight", "loss", "(", "p=", "0.01", ")", ".", "Combining", "technology", "-", "based", "self", "-", "monitoring", "tools", "with", "phone", "counseling", "supported", "weight", "loss", "over", "6", "months", "in", "women", "at", "increased", "risk", "for", "breast", "cancer", "." ]

[ 17, 18, 18, 18, 18, 18, 18, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 19, 20, 0, 0, 0, 5, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 16, 16, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 16, 16, 16, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 21, 22, 22, 22, 0, 33, 34, 0, 35, 36, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 33, 34, 0, 35, 36, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "SOLTI", "NeoPARP", ":", "a", "phase", "II", "randomized", "study", "of", "two", "schedules", "of", "iniparib", "plus", "paclitaxel", "versus", "paclitaxel", "alone", "as", "neoadjuvant", "therapy", "in", "patients", "with", "triple", "-", "negative", "breast", "cancer", ".", "Iniparib", "is", "an", "investigational", "agent", "with", "antitumor", "activity", "of", "controversial", "mechanism", "of", "action", ".", "Two", "previous", "trials", "in", "advanced", "triple", "-", "negative", "breast", "cancer", "(", "TNBC", ")", "in", "combination", "with", "gemcitabine", "and", "carboplatin", "showed", "some", "evidence", "of", "efficacy", "that", "was", "not", "confirmed", ".", "This", "phase", "II", "randomized", "neoadjuvant", "study", "was", "designed", "to", "explore", "its", "activity", "and", "tolerability", "with", "weekly", "paclitaxel", "(", "PTX", ")", "as", "neoadjuvant", "treatment", "in", "TNBC", "patients", ".", "141", "patients", "with", "Stage", "II", "-", "IIIA", "TNBC", "were", "randomly", "assigned", "to", "receive", "PTX", "(", "80", "mg", "/", "m", "(", "2", ")", ",", "d", "1", ";", "n", "=", "47", ")", "alone", "or", "in", "combination", "with", "iniparib", ",", "either", "once", "-", "weekly", "(", "PWI", ")", "(", "11.2", "mg", "/", "kg", ",", "d", "1", ";", "n", "=", "46", ")", "or", "twice", "-", "weekly", "(", "PTI", ")", "(", "5.6", "mg", "/", "kg", ",", "d", "1", ",", "4", ";", "n", "=", "48", ")", "for", "12", "weeks", ".", "Primary", "endpoint", "was", "pathologic", "complete", "response", "(", "pCR", ")", "in", "the", "breast", ".", "pCR", "rate", "was", "similar", "among", "the", "three", "arms", "(", "21", ",", "22", ",", "and", "19", "%", "for", "PTX", ",", "PWI", ",", "and", "PTI", ",", "respectively", ")", ".", "Secondary", "efficacy", "endpoints", "were", "comparable", ":", "pCR", "in", "breast", "and", "axilla", "(", "21", ",", "17", ",", "and", "19", "%", ")", ";", "best", "overall", "response", "in", "the", "breast", "(", "60", ",", "61", ",", "and", "63", "%", ")", ";", "and", "breast", "conservation", "rate", "(", "53", ",", "54", ",", "and", "50", "%", ")", ".", "Slightly", "more", "patients", "in", "the", "PTI", "arm", "presented", "grade", "3", "/", "4", "neutropenia", "(", "4", ",", "0", ",", "and", "10", "%", ")", ".", "Grade", "1", "/", "2", "(", "28", ",", "22", ",", "and", "29", "%", ")", ",", "but", "no", "grade", "3", "/", "4", "neuropathy", ",", "was", "observed", ".", "There", "were", "no", "differences", "in", "serious", "adverse", "events", "and", "treatment", "-", "emergent", "adverse", "events", "leading", "to", "treatment", "discontinuation", "among", "the", "three", "arms", ".", "Addition", "of", "iniparib", "to", "weekly", "PTX", "did", "not", "add", "relevant", "antitumor", "activity", "or", "toxicity", ".", "These", "results", "do", "not", "support", "further", "evaluation", "of", "the", "combination", "of", "iniparib", "at", "these", "doses", "plus", "paclitaxel", "in", "early", "TNBC", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 19, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 31, 0, 29, 0, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 31, 0, 29, 0, 0, 29, 30, 0, 0, 21, 22, 22, 0, 0, 0, 0, 31, 0, 29, 0, 0, 29, 30, 0, 0, 0, 21, 22, 22, 0, 31, 0, 29, 0, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 31, 0, 29, 0, 0, 29, 30, 0, 0, 21, 22, 22, 22, 0, 31, 0, 29, 0, 0, 29, 30, 0, 0, 0, 27, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Globo", "H", "-", "KLH", "vaccine", "adagloxad", "simolenin", "(", "OBI-", "822", ")", "/", "OBI-", "821", "in", "patients", "with", "metastatic", "breast", "cancer", ":", "phase", "II", "randomized", ",", "placebo", "-", "controlled", "study", ".", "This", "randomized", ",", "double", "-", "blind", ",", "placebo", "-", "controlled", ",", "parallel", "-", "group", ",", "phase", "II", "trial", "assessed", "the", "efficacy", "and", "safety", "of", "adagloxad", "simolenin", "(", "OBI-", "822", ";", "a", "Globo", "H", "epitope", "covalently", "linked", "to", "keyhole", "limpet", "hemocyanin", "(", "KLH", ")", ")", "with", "adjuvant", "OBI-", "821", "in", "metastatic", "breast", "cancer", "(", "MBC", ")", ".", "At", "40", "sites", "in", "Taiwan", ",", "USA", ",", "Korea", ",", "India", ",", "and", "Hong", "Kong", ",", "patients", "with", "MBC", "of", "any", "molecular", "subtype", "and", "≤", "2", "prior", "progressive", "disease", "events", "with", "stable", "/", "responding", "disease", "after", "the", "last", "anticancer", "regimen", "were", "randomized", "(", "2", ":1", ")", "to", "adagloxad", "simolenin", "(", "AS", "/", "OBI-", "821", ")", "or", "placebo", ",", "subcutaneously", "for", "nine", "doses", "with", "low", "-", "dose", "cyclophosphamide", ".", "The", "primary", "endpoint", "was", "progression", "-", "free", "survival", "(", "PFS", ")", ".", "Secondary", "endpoints", "included", "overall", "survival", ",", "correlation", "of", "clinical", "outcome", "with", "humoral", "immune", "response", "and", "Globo", "H", "expression", ",", "and", "safety", ".", "Of", "349", "patients", "randomized", ",", "348", "received", "study", "drug", ".", "Patients", "with", "the", "following", "breast", "cancer", "subtypes", "were", "included", ":", "hormone", "receptor", "-", "positive", "(", "HR+", ")", "/", "human", "epidermal", "growth", "factor", "receptor", "2", "-negative", "(", "HER", "2", "-", ")", "(", "70.4", "%", ")", ",", "triple", "negative", "(", "12.9", "%", ")", ",", "and", "HER", "2", "+", "(", "16.7", "%", ")", ",", "similarly", "distributed", "between", "treatment", "arms", ".", "Median", "PFS", "was", "7.6", "months", "(", "95", "%", "CI", ":", "6.5", "-", "10.9", ")", "with", "AS", "/", "OBI-", "821", "(", "n=", "224", ")", "and", "9.2", "months", "(", "95", "%", "CI", ":", "7.3", "-", "11.3", ")", "with", "placebo", "(", "n=", "124", ")", "(", "HR=", "0.96", ";", "95", "%", "CI", ":", "0.74", "-", "1.25", ";", "p=", "0.77", ")", ",", "with", "no", "difference", "by", "breast", "cancer", "subtype", ".", "AS", "/", "OBI-", "821", "recipients", "with", "anti", "-", "Globo", "H", "IgG", "titer", "≥", "1", ":", "160", "had", "significantly", "longer", "median", "PFS", "(", "11.1", "months", "(", "95", "%", "CI", ":", "9.3", "-", "17.6", ")", ")", "versus", "those", "with", "titers", "<", "1", ":", "160", "(", "5.5", "months", "(", "95", "%", "CI", ":", "3.7", "-", "5.6", ")", ";", "HR=", "0.52", ";", "p", "<", "0.0001", ")", "and", "placebo", "recipients", "(", "HR=", "0.71", ";", "p=", "0.03", ")", ".", "Anti", "-", "KLH", "immune", "responses", "were", "similar", "at", "week", "40", "between", "AS", "/", "OBI-", "821", "recipients", "with", "anti", "-", "Globo", "IgG", "titer", "≥", "1", ":", "160", "and", "those", "with", "anti", "-", "Globo", "IgG", "titer", "<", "1", ":", "160", ".", "The", "most", "common", "adverse", "events", "with", "AS", "/", "OBI-", "821", "were", "grade", "1", "or", "2", "injection", "site", "reactions", "(", "56.7", "%", ";", "placebo", ",", "8.9", "%", ")", "and", "fever", "(", "20.1", "%", ";", "placebo", ",", "6.5", "%", ")", ".", "AS", "/", "OBI-", "821", "did", "not", "improve", "PFS", "in", "patients", "with", "previously", "treated", "MBC", ".", "However", ",", "humoral", "immune", "response", "to", "Globo", "H", "correlated", "with", "improved", "PFS", "in", "AS", "/", "OBI-", "821", "recipients", ",", "leading", "the", "way", "to", "further", "marker", "-", "driven", "studies", ".", "Treatment", "was", "well", "tolerated", ".", "NCT", "01516307", "." ]

[ 17, 18, 18, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 16, 16, 16, 16, 16, 16, 16, 16, 16, 16, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 23, 24, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 23, 0, 0, 1, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 29, 30, 0, 0, 0, 31, 32, 0, 0, 21, 0, 29, 30, 0, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Double", "-", "Blind", ",", "Randomized", "Trial", "of", "Alternative", "Letrozole", "Dosing", "Regimens", "in", "Postmenopausal", "Women", "with", "Increased", "Breast", "Cancer", "Risk", ".", "Aromatase", "inhibitors", "(", "AI", ")", "profoundly", "suppress", "estrogen", "levels", "in", "postmenopausal", "women", "and", "are", "effective", "in", "breast", "cancer", "prevention", "among", "high", "-", "risk", "postmenopausal", "women", ".", "Unfortunately", ",", "AI", "treatment", "is", "associated", "with", "undesirable", "side", "effects", "that", "limit", "patient", "acceptance", "for", "primary", "prevention", "of", "breast", "cancer", ".", "A", "double", "-", "blind", ",", "randomized", "trial", "was", "conducted", "to", "determine", "whether", "low", "and", "intermittent", "doses", "of", "letrozole", "can", "achieve", "effective", "estrogen", "suppression", "with", "a", "more", "favorable", "side", "-", "effect", "profile", ".", "Overall", ",", "112", "postmenopausal", "women", "at", "increased", "risk", "for", "breast", "cancer", "were", "randomized", "to", "receive", "letrozole", "at", "2.5", "mg", "once", "daily", "(", "QD", ",", "standard", "dose", "arm", ")", ",", "2.5", "mg", "every", "Monday", ",", "Wednesday", ",", "and", "Friday", "(", "Q", "-", "MWF", ")", ",", "1.0", "mg", "Q", "-", "MWF", ",", "or", "0.25", "mg", "Q", "-", "MWF", "for", "24", "weeks", ".", "Primary", "endpoint", "was", "suppression", "in", "serum", "estradiol", "levels", "at", "the", "end", "of", "letrozole", "intervention", ".", "Secondary", "endpoints", "included", "changes", "in", "serum", "estrone", ",", "testosterone", ",", "C", "-", "telopeptide", "(", "marker", "of", "bone", "resorption", ")", ",", "lipid", "profile", ",", "and", "quality", "-", "of", "-", "life", "measures", "(", "QoL", ")", "following", "treatment", ".", "Significant", "estrogen", "suppression", "was", "observed", "in", "all", "dose", "arms", "with", "an", "average", "of", "75", "%", "to", "78", "%", "and", "86", "%", "to", "93", "%", "reduction", "in", "serum", "estradiol", "and", "estrone", "levels", ",", "respectively", ".", "There", "were", "no", "differences", "among", "dose", "arms", "with", "respect", "to", "changes", "in", "C", "-", "telopeptide", "levels", ",", "lipid", "profile", ",", "adverse", "events", "(", "AE", ")", ",", "or", "QoL", "measures", ".", "We", "conclude", "that", "low", "and", "intermittent", "doses", "of", "letrozole", "are", "not", "inferior", "to", "standard", "dose", "in", "estrogen", "suppression", "and", "resulted", "in", "a", "similar", "side", "-", "effect", "profile", "compared", "with", "standard", "dose", ".", "Further", "studies", "are", "needed", "to", "determine", "the", "feasibility", "of", "selecting", "an", "effective", "AI", "dosing", "schedule", "with", "better", "tolerability", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 17, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 9, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 0, 23, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 0, 23, 24, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 21, 22, 0, 21, 22, 22, 22, 22, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Long", "-", "term", "cardiac", "follow", "-", "up", "in", "relapse", "-", "free", "patients", "after", "six", "courses", "of", "fluorouracil", ",", "epirubicin", ",", "and", "cyclophosphamide", ",", "with", "either", "50", "or", "100", "mg", "of", "epirubicin", ",", "as", "adjuvant", "therapy", "for", "node", "-", "positive", "breast", "cancer", ":", "French", "adjuvant", "study", "group", ".", "PURPOSE", "To", "evaluate", "long", "-", "term", "cardiac", "function", "in", "patients", "without", "disease", "who", "had", "received", "six", "cycles", "of", "fluorouracil", "500", "mg", "/", "m", "(", "2", ")", ",", "epirubicin", "50", "mg", "/", "m", "(", "2", ")", ",", "and", "cyclophosphamide", "500", "mg", "/", "m", "(", "2", ")", "(", "FEC", "50", ")", "or", "the", "same", "regimen", "with", "epirubicin", "100", "mg", "/", "m", "(", "2", ")", "(", "FEC", "100", ")", "as", "adjuvant", "chemotherapy", "for", "node", "-", "positive", "breast", "cancer", "in", "the", "French", "Adjuvant", "Study", "Group-", "05", "trial", ".", "PATIENTS", "AND", "METHODS", "One", "hundred", "fifty", "patients", "(", "FEC", "50", ",", "n", "=", "65", ";", "FEC", "100", ",", "n", "=", "85", ")", "who", "were", "without", "disease", "and", "who", "gave", "their", "informed", "consent", "were", "enrolled", "for", "long", "-", "term", "cardiac", "assessment", ".", "The", "assessment", "included", "cardiac", "events", "occurring", "after", "the", "end", "of", "chemotherapy", ",", "vital", "signs", ",", "concomitant", "disease", ",", "ECG", ",", "isotopic", "left", "ventricular", "ejection", "fraction", "(", "LVEF", ")", ",", "and", "echographic", "parameters", ".", "Abnormal", "files", "were", "blindly", "reviewed", "by", "cardiologists", "and", "oncologists", ".", "Results", "The", "median", "follow", "-", "up", "time", "was", "102", "months", ".", "After", "FEC", "100", ",", "LVEF", "was", "less", "than", "50", "%", "in", "five", "patients", "(", "radioisotopic", "method", ")", ",", "and", "two", "patients", "experienced", "congestive", "heart", "failure", "(", "CHF", ")", "that", "was", "possibly", "related", "to", "treatment", ".", "Asymptomatic", "left", "ventricular", "dysfunction", "(", "LVD", ")", "was", "experienced", "in", "18", "patients", "after", "FEC", "100", "and", "in", "one", "patient", "after", "FEC", "50", ".", "In", "these", "patients", ",", "treatment", "causality", "was", "probable", "in", "eight", "patients", ".", "Two", "additional", "years", "after", "this", "assessment", ",", "all", "18", "patients", "were", "still", "asymptomatic", ".", "CONCLUSION", "After", "more", "than", "8", "years", "of", "follow", "-", "up", ",", "the", "cardiac", "toxicity", "observed", "after", "adjuvant", "treatment", "with", "FEC", "100", "comprised", "two", "cases", "of", "well", "-", "controlled", "CHF", "and", "18", "cases", "of", "asymptomatic", "LVD", ".", "In", "the", "majority", "of", "women", "with", "primary", "breast", "cancer", ",", "the", "benefits", "of", "treatment", "with", "FEC", "100", "in", "terms", "of", "disease", "-", "free", "and", "overall", "survival", "outweigh", "the", "risks", ",", "and", "cardiac", "risk", "factors", "should", "be", "carefully", "evaluated", "in", "patient", "selection", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 15, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 3, 0, 19, 20, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 25, 0, 0, 0, 0, 0, 0, 0, 25, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 0, 0, 25, 0, 0, 0, 0, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Impact", "of", "exercise", "training", "on", "cardiotoxicity", "and", "cardiac", "health", "outcomes", "in", "women", "with", "breast", "cancer", "anthracycline", "chemotherapy", ":", "a", "study", "protocol", "for", "a", "randomized", "controlled", "trial", ".", "Anthracyclines", "are", "chemotherapeutic", "agents", "frequently", "used", "in", "breast", "cancer", "(", "BC", ")", "treatment", ".", "Although", "it", "improves", "disease", "-", "free", "and", "overall", "survival", ",", "the", "use", "of", "anthracyclines", "is", "associated", "with", "a", "cumulative", "risk", "of", "cardiac", "toxicity", ".", "Preventive", "strategies", "to", "optimize", "cardiac", "health", "are", "needed", "and", "exercise", "is", "proposed", "as", "a", "potential", "non", "-", "pharmacological", "approach", "for", "counteracting", "anthracycline", "-", "related", "cardiotoxicity", "(", "ARC", ")", ".", "Most", "of", "the", "data", "on", "the", "effects", "of", "exercise", "to", "reduce", "ACT", "are", "from", "animal", "studies", ",", "with", "only", "a", "few", "studies", "in", "a", "limited", "number", "of", "patients", "indicating", "beneficial", "effects", ".", "To", "better", "understand", "the", "effectiveness", "of", "exercise", "in", "the", "mitigation", "of", "ARC", ",", "clinical", ",", "real", "-", "world", "trials", "claim", "require", "a", "larger", "sample", "size", "and", "more", "accurate", "and", "valuable", "clinical", "biomarkers", ".", "In", "this", "study", ",", "we", "intend", "to", "include", "a", "large", "sample", "and", "investigate", "cardiac", "function", "through", "serial", "measures", "of", "biomarkers", "and", "imaging", "techniques", ".", "This", "protocol", "describes", "a", "two", "-", "arm", ",", "prospective", ",", "randomized", "controlled", "trial", "that", "will", "explore", "the", "cardioprotective", "effect", "of", "a", "structured", "exercise", "program", "in", "women", "with", "BC", "undergoing", "anthracycline", "-", "containing", "chemotherapy", "(", "ACT", ")", ".", "Ninety", "adult", "women", "with", "early", "BC", "and", "recommended", "to", "receive", "ACT", "will", "be", "randomly", "assigned", "(", "1", ":1", ")", "to", "an", "intervention", "group", "or", "a", "control", "group", ".", "Patients", "allocated", "to", "the", "intervention", "group", "will", "perform", "a", "supervised", "exercise", "program", "three", "times", "per", "week", ",", "consisting", "of", "a", "combination", "of", "aerobic", "and", "resistance", "training", "with", "progressive", "intensity", "and", "volume", ",", "during", "the", "time", "period", "they", "receive", "ACT", ".", "The", "control", "group", "will", "receive", "standard", "BC", "care", ".", "Primary", "outcomes", "related", "to", "cardiac", "(", "dys", ")", "function", "will", "be", "circulating", "N", "-", "terminal", "pro", "-", "brain", "natriuretic", "peptide", "(", "NT", "-", "proBNP", ")", "levels", ",", "resting", "left", "ventricular", "(", "LV", ")", "longitudinal", "strain", ",", "and", "resting", "LV", "ejection", "fraction", ".", "Secondary", "outcomes", "will", "include", "the", "assessment", "of", "resting", "blood", "pressure", ",", "resting", "heart", "rate", "(", "HR", ")", ",", "resting", "HR", "variability", "(", "HRV", ")", ",", "recovery", "HR", ",", "physical", "function", "outcomes", ",", "self", "-", "reported", "physical", "activity", "level", ",", "health", "-", "related", "quality", "of", "life", ",", "and", "fatigue", ".", "Data", "will", "be", "obtained", "at", "baseline", "(", "t", "0", ")", ",", "after", "the", "end", "of", "anthracycline", "-", "treatment", "(", "t", "2", ")", ",", "and", "3", "months", "after", "t", "2", "(", "t", "3", ")", ".", "Additionally", ",", "NT", "-", "proBNP", "will", "be", "measured", "1", "-", "24", "h", "prior", "to", "each", "anthracycline", "-", "treatment", "cycle", "(", "t", "1", ")", ".", "The", "implementation", "of", "the", "present", "study", "design", ",", "using", "novel", "clinical", "biomarkers", ",", "will", "determine", "the", "effect", "of", "structured", "exercise", "interventions", "at", "mitigating", "ARC", ",", "with", "the", "overall", "aim", "of", "finding", "means", "to", "further", "improve", "BC", "care", ".", "ISRCTN", ",", "ISRCTN", "32617901", ".", "Registered", "on", "24", "October", "2018", ".", "Last", "updated", "on", "11", "January", "2019", "." ]

[ 0, 0, 17, 18, 0, 13, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 0, 23, 24, 24, 24, 24, 24, 24, 24, 0, 0, 23, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 0, 23, 24, 24, 24, 24, 24, 0, 23, 24, 24, 24, 24, 24, 0, 23, 24, 0, 23, 24, 24, 0, 23, 24, 24, 24, 24, 24, 0, 23, 24, 24, 24, 24, 24, 0, 0, 23, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Willingness", "to", "participate", "in", "mammography", "screening", ":", "a", "randomized", "controlled", "questionnaire", "study", "of", "responses", "to", "two", "patient", "information", "leaflets", "with", "different", "factual", "content", ".", "From", "2010", "onward", ",", "a", "new", "leaflet", "about", "mammography", "screening", "for", "breast", "cancer", ",", "more", "informative", "than", "the", "preceding", "version", ",", "has", "been", "sent", "to", "women", "in", "Germany", "aged", "50", "to", "69", "with", "the", "invitation", "to", "undergo", "screening", ".", "The", "purpose", "of", "this", "study", "was", "to", "determine", "the", "effect", "of", "different", "informational", "content", "on", "the", "decision", "whether", "or", "not", "to", "be", "screened", ".", "In", "a", "randomized", "and", "blinded", "design", ",", "792", "women", "aged", "48", "to", "49", "were", "sent", "either", "the", "old", "or", "the", "new", "leaflet", ".", "Questionnaires", "were", "sent", "together", "with", "the", "leaflets", "in", "order", "to", "assess", "the", "following", ":", "willingness", "to", "undergo", "mammography", "screening", ",", "knowledge", ",", "decisional", "confidence", ",", "personal", "experiences", "of", "breast", "cancer", ",", "and", "demographic", "data", ".", "370", "(", "46.7", "%", ")", "of", "the", "questionnaires", "were", "returned", ",", "and", "353", "were", "evaluable", ".", "The", "two", "groups", "did", "not", "differ", "significantly", "in", "their", "willingness", "to", "be", "screened", ":", "81.5", "%", "(", "95", "%", "confidence", "interval", "[", "CI", "]", "75.8", "%", "-", "87.2", "%", ")", "versus", "88.6", "%", "(", "95", "%", "CI", "83.9", "%", "-", "91.3", "%", ",", "p", "=", "0.060", ")", ".", "A", "post", "-", "hoc", "analysis", "showed", "that", "women", "who", "reported", "having", "had", "personal", "experience", "of", "breast", "cancer", "(", "18.7", "%", ")", "were", "more", "willing", "to", "be", "screened", "if", "they", "were", "given", "the", "new", "leaflet", ",", "rather", "than", "the", "old", "one", "(", "interaction", "p", "=", "0.014", ")", ".", "The", "two", "groups", "did", "not", "differ", "in", "their", "knowledge", "about", "screening", "(", "p", "=", "0.260", ")", ".", "Women", "who", "received", "the", "old", "leaflet", "reported", "a", "higher", "decisional", "confidence", "(", "p", "=", "0.017", ")", ".", "The", "most", "commonly", "mentioned", "factors", "affecting", "the", "decision", "were", "experience", "of", "breast", "cancer", "in", "relatives", "and", "close", "acquaintances", "(", "26.5", "%", "of", "mentions", ")", "and", "a", "doctor", "'s", "recommendation", "(", "48.2", "%", ")", ".", "Leaflets", "(", "3.6", "%", ")", "and", "all", "other", "factors", "played", "only", "a", "secondary", "role", ".", "The", "greater", "or", "lesser", "informativeness", "of", "the", "leaflet", "affected", "neither", "the", "participants", "'", "knowledge", "of", "mammography", "screening", "nor", "their", "willingness", "to", "undergo", "it", ".", "The", "leaflet", "was", "not", "seen", "as", "an", "aid", "to", "decision", "-", "making", ".", "The", "best", "way", "to", "assure", "an", "informed", "decision", "about", "screening", "may", "be", "for", "the", "patient", "to", "discuss", "the", "matter", "personally", "with", "a", "qualified", "professional", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 13, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Inhibition", "of", "EGFR", ",", "HER", "2", ",", "and", "HER", "3", "signaling", "with", "AZD", "8931", "in", "combination", "with", "anastrozole", "as", "an", "anticancer", "approach", ":", "Phase", "II", "randomized", "study", "in", "women", "with", "endocrine", "-", "therapy", "-", "naïve", "advanced", "breast", "cancer", ".", "AZD", "8931", "is", "an", "orally", "bioavailable", ",", "reversible", "tyrosine", "kinase", "inhibitor", "of", "EGFR", ",", "HER", "2", ",", "and", "HER", "3", "signaling", ".", "The", "Phase", "II", "MINT", "study", "(", "ClinicalTrials", ".", "gov", "NCT", "01151215", ")", "investigated", "whether", "adding", "AZD", "8931", "to", "endocrine", "therapy", "would", "delay", "development", "of", "endocrine", "resistance", "in", "patients", "with", "hormone", "-", "sensitive", "advanced", "breast", "cancer", ".", "Patients", "were", "randomized", "1", ":1", ":1", "to", "receive", "daily", "anastrozole", "(", "1", "mg", ")", "in", "combination", "with", "AZD", "8931", "20", "mg", "twice", "daily", "(", "bid", ")", ",", "AZD", "8931", "40", "mg", "bid", ",", "or", "placebo", ".", "The", "primary", "objective", "was", "evaluation", "of", "progression", "-", "free", "survival", "(", "PFS", ")", "in", "patients", "treated", "with", "combination", "AZD", "8931", "and", "anastrozole", "versus", "anastrozole", "alone", ".", "Secondary", "objectives", "included", "assessment", "of", "safety", "and", "tolerability", ",", "objective", "response", "rate", ",", "and", "overall", "survival", ".", "At", "the", "interim", "analysis", ",", "359", "patients", "were", "randomized", "and", "received", "anastrozole", "in", "combination", "with", "AZD", "8931", "20", "mg", "(", "n", "=", "118", ")", ",", "40", "mg", "(", "n", "=", "120", ")", ",", "or", "placebo", "(", "n", "=", "121", ")", ";", "39", "%", "of", "patients", "(", "n", "=", "141", ")", "had", "a", "progression", "event", ".", "Median", "PFS", "(", "HR", ";", "95", "%", "CI", "vs", "placebo", ")", "in", "the", "AZD", "8931", "20", ",", "40", "mg", ",", "and", "placebo", "arms", "was", "10.9", "(", "1.37", ";", "0.91", "-", "2.06", ",", "P", "=", "0.135", ")", ",", "13.8", "(", "1.16", ";", "0.77", "-", "1.75", ",", "P", "=", "0.485", ")", ",", "and", "14.0", "months", ",", "respectively", ".", "No", "indication", "of", "clinical", "benefit", "was", "observed", "following", "treatment", "with", "AZD", "8931", "for", "the", "secondary", "endpoints", ".", "Safety", "findings", "showed", "a", "greater", "incidence", "of", "diarrhea", "(", "40", ",", "51", ",", "and", "12", "%", "for", "AZD", "8931", "20", ",", "40", "mg", ",", "and", "placebo", ",", "respectively", ")", ",", "rash", "(", "32", ",", "48", ",", "and", "12", "%", ")", ",", "dry", "skin", "(", "19", ",", "25", ",", "and", "2", "%", ")", ",", "and", "acneiform", "dermatitis", "(", "16", ",", "28", ",", "and", "2", "%", ")", "in", "patients", "treated", "with", "AZD", "8931", "versus", "placebo", ".", "AZD", "8931", ",", "in", "combination", "with", "endocrine", "therapy", ",", "does", "not", "appear", "to", "enhance", "endocrine", "responsiveness", "and", "is", "associated", "with", "greater", "skin", "and", "gastrointestinal", "toxicity", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 0, 23, 24, 24, 0, 0, 23, 24, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 19, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 37, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 37, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 39, 40, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 29, 0, 29, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 29, 0, 29, 0, 0, 31, 32, 0, 0, 21, 22, 0, 29, 0, 29, 0, 0, 31, 32, 0, 0, 0, 21, 22, 0, 29, 0, 29, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Trastuzumab", "plus", "vinorelbine", "or", "taxane", "chemotherapy", "for", "HER", "2", "-", "overexpressing", "metastatic", "breast", "cancer", ":", "the", "trastuzumab", "and", "vinorelbine", "or", "taxane", "study", ".", "The", "optimal", "trastuzumab", "-", "based", "chemotherapy", "regimen", "for", "HER", "2", "-", "overexpressing", ",", "metastatic", "breast", "cancer", "is", "not", "known", ".", "The", "trastuzumab", "and", "vinorelbine", "or", "taxane", "(", "TRAVIOTA", ")", "study", "was", "a", "prospective", ",", "multicenter", ",", "randomized", "trial", "that", "was", "designed", "to", "compare", "these", "regimens", ".", "Eligible", "patients", "had", "HER", "2", "-", "overexpressing", ",", "metastatic", "breast", "cancer", "and", "had", "received", "no", "prior", "chemotherapy", "for", "advanced", "disease", ".", "Patients", "were", "randomized", "1", ":1", "to", "receive", "either", "trastuzumab", "with", "weekly", "vinorelbine", "therapy", "or", "weekly", "taxane", "therapy", "(", "paclitaxel", "or", "docetaxel", "at", "the", "investigator", "'s", "choice", ")", ".", "Originally", "planned", "for", "250", "patients", ",", "the", "study", "was", "closed", "because", "of", "poor", "accrual", "with", "81", "evaluable", "patients", ",", "including", "41", "patients", "who", "received", "vinorelbine", "and", "40", "patients", "who", "received", "taxane", ".", "Response", "rates", "were", "51", "%", "and", "40", "%", "for", "the", "vinorelbine", "/", "trastuzumab", "arm", "and", "the", "taxane", "/", "trastuzumab", "arm", ",", "respectively", "(", "Fisher", "exact", "test", ";", "P", "=", ".", "37", ")", ".", "The", "median", "time", "to", "disease", "progression", "was", "8.5", "months", "and", "6.0", "months", "for", "the", "vinorelbine-", "and", "taxane", "-", "based", "arms", ",", "respectively", "(", "log", "-", "rank", "test", ";", "P", "=", ".", "09", ")", ".", "Treatment", "with", "either", "regimen", "generally", "was", "well", "tolerated", ",", "yielding", "comparable", "rates", "of", "neurologic", "and", "gastrointestinal", "toxicity", ".", "Vinorelbine", "-", "based", "treatment", "was", "associated", "with", "more", "anemia", "and", "neutropenia", "and", "with", "2", "episodes", "of", "cardiotoxicity", ".", "Taxane", "-", "based", "therapy", "was", "associated", "with", "more", "dermatologic", "toxicity", ",", "myalgias", ",", "and", "fluid", "retention", ".", "Both", "vinorelbine", "/", "trastuzumab", "and", "taxane", "/", "trastuzumab", "treatments", "were", "active", "as", "first", "-", "line", "therapy", "for", "HER", "2", "-", "positive", ",", "metastatic", "breast", "cancer", "and", "had", "comparable", "rates", "of", "efficacy", "and", "tolerability", ".", "The", "toxicities", "observed", "were", "the", "result", "of", "recognized", "side", "effects", "associated", "with", "each", "of", "the", "chemotherapy", "agents", "and", "schedules", ".", "These", "data", "can", "inform", "treatment", "decision", "making", "in", "this", "clinical", "setting", "." ]

[ 0, 0, 17, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 21, 22, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 37, 38, 0, 39, 40, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 25, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 21, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "randomized", ",", "phase", "II", ",", "three", "-", "arm", "study", "of", "two", "schedules", "of", "ixabepilone", "or", "paclitaxel", "plus", "bevacizumab", "as", "first", "-", "line", "therapy", "for", "metastatic", "breast", "cancer", ".", "The", "aim", "of", "this", "phase", "II", "trial", "was", "to", "estimate", "the", "objective", "response", "rate", "(", "ORR", ")", "of", "two", "different", "schedules", "of", "ixabepilone", "[", "weekly", "or", "every", "3", "weeks", "(", "Q", "3", "W", ")", "]", "combined", "with", "bevacizumab", ",", "relative", "to", "a", "reference", "arm", "of", "weekly", "paclitaxel", "and", "bevacizumab", ".", "Patients", "with", "human", "epidermal", "growth", "factor", "receptor", "2", "-normal", ",", "chemotherapy", "-", "naïve", "metastatic", "breast", "cancer", "(", "MBC", ")", "were", "randomized", "3", ":3", ":", "2", "to", "ixabepilone", "16", "mg", "/", "m", "(", "2", ")", "weekly", "plus", "bevacizumab", "10", "mg", "/", "kg", "Q", "2", "W", "(", "Arm", "A", ":", "n", "=", "46", ")", ";", "ixabepilone", "40", "mg", "/", "m", "(", "2", ")", "Q", "3", "W", "(", "reduced", "to", "32", "mg", "/", "m", "(", "2", ")", "after", "four", "cycles", "of", "treatment", ")", "plus", "bevacizumab", "15", "mg", "/", "kg", "Q", "3", "W", "(", "Arm", "B", ":", "n", "=", "45", ")", ";", "or", "paclitaxel", "90", "mg", "/", "m", "(", "2", ")", "weekly", "plus", "bevacizumab", "10", "mg", "/", "kg", "intravenous", "infusion", "Q", "2", "W", "(", "Arm", "C", ":", "n", "=", "32", ")", ".", "Of", "123", "randomized", "patients", ",", "122", "were", "treated", ".", "All", "were", "followed", "for", "≥", "19", "months", ";", "5", "%", "of", "patients", "remained", "on", "study", "treatment", "at", "the", "time", "of", "this", "analysis", ".", "Grade", "3", "or", "4", "neutropenia", "was", "more", "common", "in", "Arm", "B", "(", "60", "%", ")", "than", "Arms", "A", "(", "16", "%", ")", "or", "C", "(", "22", "%", ")", ";", "other", "adverse", "events", "were", "similar", ".", "The", "investigator", "-", "assessed", "ORR", "was", "48", ",", "71", ",", "and", "63", "%", "for", "Arms", "A", ",", "B", ",", "and", "C", ",", "respectively", ".", "Median", "progression", "-", "free", "survival", "(", "randomized", "patients", ")", "was", "9.6", "months", "in", "Arm", "A", ",", "11.9", "months", "in", "Arm", "B", ",", "and", "13.5", "months", "in", "Arm", "C", ".", "In", "conclusion", ",", "ixabepilone", "Q", "3", "W", "plus", "bevacizumab", "has", "clinical", "activity", "as", "first", "-", "line", "therapy", "for", "MBC", "relative", "to", "paclitaxel", "plus", "bevacizumab", ",", "but", "with", "significantly", "greater", "risk", "of", "grade", "3", "or", "4", "neutropenia", ".", "In", "addition", ",", "these", "data", "suggest", "that", "weekly", "dosing", "of", "ixabepilone", "may", "be", "less", "active", "than", "Q", "3", "W", "dosing", ",", "but", "with", "less", "neutropenia", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 0, 19, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 0, 0, 0, 0, 29, 30, 0, 0, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 29, 0, 29, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 37, 38, 0, 0, 0, 0, 37, 38, 0, 0, 0, 0, 0, 39, 40, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "effect", "of", "metformin", "on", "apoptosis", "in", "a", "breast", "cancer", "presurgical", "trial", ".", "Metformin", "has", "been", "associated", "with", "antitumour", "activity", "in", "breast", "cancer", "(", "BC", ")", "but", "its", "mechanism", "remains", "unclear", ".", "We", "determined", "whether", "metformin", "induced", "a", "modulation", "of", "apoptosis", "by", "terminal", "deoxynucleotidyl", "transferase", "dUTP", "nick", "end", "labelling", "(", "TUNEL", ")", "overall", "and", "by", "insulin", "resistance", "status", "in", "a", "presurgical", "trial", ".", "Apoptosis", "was", "analysed", "in", "core", "biopsies", "and", "in", "surgical", "samples", "from", "100", "non", "-", "diabetic", "BC", "patients", "participating", "in", "a", "randomised", "trial", "of", "metformin", "vs", "placebo", "given", "for", "4", "weeks", "before", "surgery", ".", "Eighty", "-", "seven", "subjects", "(", "45", "on", "metformin", "and", "42", "on", "placebo", ")", "were", "assessable", "for", "TUNEL", "measurement", "at", "both", "time", "points", ".", "TUNEL", "levels", "at", "surgery", "were", "higher", "than", "that", "at", "baseline", "core", "biopsy", "(", "P", "<", "0.0001", ")", ",", "although", "no", "difference", "between", "arms", "was", "noted", "(", "metformin", "arm", ":", "median", "difference", "surgery", "-", "biopsy", "levels", "+", "4", "%", ",", "interquartile", "range", "(", "IQR", ")", ":", "2", "-", "12", ";", "placebo", "arm", ":", "+", "2", "%", ",", "IQR", ":", "0", "-", "8", ",", "P=", "0.2", ")", ".", "Ki", "67", "labelling", "index", "and", "TUNEL", "levels", "were", "directly", "correlated", "both", "at", "baseline", "and", "surgery", "(", "Spearman", "'s", "r=", "0.51", ",", "P", "<", "0.0001", ")", ".", "In", "the", "59", "women", "without", "insulin", "resistance", "(", "HOMA", "index", "<", "2.8", ")", ",", "there", "was", "a", "higher", "level", "of", "TUNEL", "at", "surgery", "on", "metformin", "vs", "placebo", "(", "median", "difference", "on", "metformin", "+", "4", "%", ",", "IQR", ":", "2", "-", "14", "vs", "+", "2", "%", ",", "IQR", ":", "0", "-", "7", "on", "placebo", ")", ",", "whereas", "an", "opposite", "trend", "was", "found", "in", "the", "28", "women", "with", "insulin", "resistance", "(", "median", "difference", "on", "metformin", "+", "2", "%", ",", "IQR", ":", "0", "-", "6", ",", "vs", "+", "5", "%", ",", "IQR", ":", "0", "-", "15", "on", "placebo", ",", "P", "-", "interaction=", "0.1", ")", ".", "Overall", ",", "we", "found", "no", "significant", "modulation", "of", "apoptosis", "by", "metformin", ",", "although", "there", "was", "a", "trend", "to", "a", "different", "effect", "according", "to", "insulin", "resistance", "status", ",", "with", "a", "pattern", "resembling", "Ki", "67", "changes", ".", "Apoptosis", "was", "significantly", "higher", "in", "the", "surgical", "specimens", "compared", "with", "baseline", "biopsy", "and", "was", "directly", "correlated", "with", "Ki", "67", ".", "Our", "findings", "provide", "additional", "evidence", "for", "a", "dual", "effect", "of", "metformin", "on", "BC", "growth", "according", "to", "insulin", "resistance", "status", "." ]

[ 0, 0, 0, 17, 0, 13, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 3, 0, 0, 0, 5, 0, 19, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Is", "it", "important", "to", "adapt", "neoadjuvant", "chemotherapy", "to", "the", "visible", "clinical", "response", "?", "An", "open", "randomized", "phase", "II", "study", "comparing", "response", "-", "guided", "and", "standard", "treatments", "in", "HER", "2", "-", "negative", "operable", "breast", "cancer", ".", "Neoadjuvant", "treatment", "provides", "a", "unique", "opportunity", "to", "evaluate", "individual", "tumor", "sensitivity", ".", "This", "study", "evaluated", "whether", "a", "response", "-", "guided", "strategy", "could", "improve", "clinical", "outcome", "compared", "with", "a", "standard", "treatment", ".", "Overall", ",", "264", "previously", "untreated", "stage", "II", "-", "III", "operable", "breast", "cancer", "patients", "were", "randomized", "to", "receive", "either", "standard", "treatment", "(", "arm", "A", ",", "n", "=", "131", ")", ",", "consisting", "of", "fluorouracil", ",", "epirubicin", ",", "and", "cyclophosphamide", "(", "FEC", "100", ":", "500", ",", "100", ",", "and", "500", "mg", "/", "m", "(", "2", ")", ",", "respectively", ",", "for", "3", "cycles", ")", "followed", "by", "docetaxel", "(", "100", "mg", "/", "m", "(", "2", ")", "for", "3", "cycles", ")", ",", "or", "adapted", "treatment", "(", "arm", "B", ",", "n", "=", "133", ")", ",", "beginning", "with", "2", "cycles", "of", "FEC", "100", "and", "switching", "to", "docetaxel", "if", "tumor", "size", "decreased", "by", "<", "30", "%", "after", "2", "cycles", "or", "<", "50", "%", "after", "4", "cycles", "of", "FEC", "100", "(", "ultrasound", "assessments", "according", "to", "World", "Health", "Organization", "criteria", ")", ".", "Otherwise", ",", "FEC", "100", "was", "given", "for", "six", "cycles", "before", "surgery", ".", "Intent", "-", "to", "-", "treat", "analysis", "was", "performed", ".", "Similar", "results", "were", "observed", "for", "clinical", "response", "(", "objective", "response", "was", "54", "%", "vs", "56", "%", ",", "p", "=", ".", "18", ")", ",", "breast", "conservation", "surgery", "(", "BCS", ";", "67", "%", "vs", "68", "%", ",", "p", "=", ".", "97", ")", ",", "and", "pathological", "complete", "response", "rate", "(", "Chevallier", "classification", ":", "14", "%", "vs", "11", "%", ",", "p", "=", ".", "68", ";", "Statloff", "classification", ":", "16", "%", "vs", "13", "%", ",", "p", "=", ".", "82", ")", "between", "arms", "A", "and", "B", ".", "Similar", "toxicities", "were", "observed", ",", "even", "with", "unbalanced", "numbers", "of", "FEC", "100", "and", "docetaxel", "courses", ".", "Adapted", "and", "standard", "treatments", "had", "similar", "results", "in", "terms", "of", "tumor", "response", ",", "BCS", "rate", ",", "and", "tolerability", ".", "Further", "survival", "outcome", "data", "are", "expected", "." ]

[ 0, 0, 0, 0, 0, 17, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 19, 20, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 21, 22, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 21, 22, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Exercise", "following", "breast", "cancer", ":", "exploratory", "survival", "analyses", "of", "two", "randomised", ",", "controlled", "trials", ".", "The", "Exercise", "for", "Health", "trials", "were", "randomised", ",", "controlled", "trials", "designed", "to", "evaluate", "an", "8", "-month", "pragmatic", "exercise", "intervention", ",", "commencing", "6", "weeks", "post", "-", "surgery", "for", "women", "with", "newly", "diagnosed", "breast", "cancer", "residing", "in", "urban", "or", "rural", "/", "regional", "Australia", ".", "For", "these", "exploratory", "analyses", ",", "the", "primary", "and", "secondary", "outcomes", "were", "overall", "survival", "(", "OS", ")", "and", "disease", "-", "free", "survival", "(", "DFS", ")", ",", "respectively", ".", "Consenting", "urban-", "(", "n", "=", "194", ")", "and", "rural", "/", "regional", "-", "residing", "women", "(", "n", "=", "143", ")", "were", "randomised", "to", "exercise", "(", "intervention", "delivered", "face", "-", "to", "-", "face", "or", "by", "telephone", ")", "or", "usual", "care", ".", "Cox", "proportional", "hazards", "models", "were", "used", "to", "estimate", "hazard", "ratios", "(", "HRs", ")", "and", "95", "%", "confidence", "intervals", "(", "CI", ")", "for", "survival", "outcomes", "(", "exercise", "group", ",", "n", "=", "207", ",", "65", "%", "urban", "women", ";", "usual", "care", "group", ",", "n", "=", "130", ",", "46", "%", "urban", "women", ")", ".", "After", "a", "median", "follow", "-", "up", "of", "8.3", "years", ",", "there", "were", "11", "(", "5.3", "%", ")", "deaths", "in", "the", "exercise", "group", "compared", "with", "15", "(", "11.5", "%", ")", "deaths", "in", "the", "usual", "care", "group", "(", "OS", "HR", "for", "the", "exercise", "group", ":", "0.45", ",", "95", "%", "CI", "0.20", "-", "0.96", ";", "p", "=", "0.04", ")", ".", "DFS", "events", "for", "the", "exercise", "versus", "usual", "care", "group", "were", "25", "(", "12.1", "%", ")", "and", "23", "(", "17.7", "%", ")", ",", "respectively", "(", "HR", ":", "0.66", ",", "95", "%", "CI", "0.38", "-", "1.17", ";", "p", "=", "0.16", ")", ".", "HRs", "for", "OS", "favoured", "exercise", "irrespective", "of", "age", ",", "body", "mass", "index", ",", "stage", "of", "disease", ",", "intervention", "compliance", ",", "and", "physical", "activity", "levels", "at", "12", "months", "post", "-", "diagnosis", ",", "although", "were", "stronger", "(", "p", "<", "0.05", ")", "for", "younger", "women", ",", "women", "with", "stage", "II", "+", "disease", ",", "women", "with", "1", "+", "comorbidity", "at", "time", "of", "diagnosis", ",", "higher", "intervention", "compliance", "and", "for", "those", "who", "met", "national", "physical", "activity", "guidelines", "at", "12", "months", "post", "-", "diagnosis", ".", "An", "exercise", "intervention", "delivered", "during", "and", "beyond", "treatment", "for", "breast", "cancer", ",", "and", "that", "was", "designed", "to", "cater", "for", "all", "women", "irrespective", "of", "place", "of", "residence", "and", "access", "to", "health", "services", ",", "has", "clear", "potential", "to", "benefit", "survival", ".", "Trial", "numbers", ":", "ACT", "RN", ":", "012606000233527", ";", "ACT", "RN", ":", "12609000809235", "." ]

[ 17, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 15, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 0, 23, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 25, 0, 29, 30, 0, 21, 0, 0, 0, 0, 0, 0, 27, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 25, 0, 29, 30, 0, 0, 27, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Comparison", "of", "ductal", "lavage", "and", "random", "periareolar", "fine", "needle", "aspiration", "as", "tissue", "acquisition", "methods", "in", "early", "breast", "cancer", "prevention", "trials", ".", "Short", "-", "term", "phase", "I", "and", "phase", "II", "breast", "cancer", "prevention", "trials", "require", "tissue", "acquisition", "at", "baseline", "and", "after", "intervention", "to", "evaluate", "modulation", "of", "potential", "biomarkers", ".", "Currently", "used", "tissue", "acquisition", "methods", "include", "ductal", "lavage", "(", "DL", ")", ",", "random", "periareolar", "fine", "needle", "aspiration", "(", "RPFNA", ")", ",", "and", "core", "needle", "biopsy", ".", "The", "optimum", "method", "to", "retrieve", "adequate", "samples", "and", "the", "most", "accepted", "method", "by", "study", "participants", "is", "not", "known", ".", "We", "compared", "RPFNA", "and", "DL", "as", "breast", "tissue", "acquisition", "methods", "for", "short", "-", "term", "breast", "cancer", "prevention", "trials", "by", "evaluating", "sample", "adequacy", "and", "tolerability", "in", "subjects", "who", "participated", "in", "two", "prospective", "phase", "II", "breast", "cancer", "prevention", "trials", ".", "Eighty", "-", "six", "women", "at", "increased", "risk", "for", "breast", "cancer", "were", "included", "in", "this", "study", "and", "underwent", "baseline", "DL", "and", "RPFNA", ".", "High", "risk", "was", "defined", "as", "having", "a", "5", "-year", "Gail", "score", "of", ">", "1.67", "%", "or", "a", "history", "of", "atypical", "hyperplasia", "(", "AH", ")", ",", "lobular", "carcinoma", ",", "or", "breast", "cancer", ".", "Median", "age", "was", "54.5", "years", "(", "range", ",", "39", "-", "75", "years", ")", ";", "75", "%", "of", "the", "women", "were", "postmenopausal", ".", "About", "51", "%", "of", "the", "women", "yielded", "nipple", "aspiration", "fluid", ",", "and", "breast", "fluid", "samples", "via", "DL", "were", "retrieved", "in", "73", "%", "of", "these", "subjects", ".", "Of", "these", "samples", ",", "71", "%", "were", "adequate", "samples", "(", "greater", "than", "10", "epithelial", "cells", ")", ".", "However", ",", "when", "the", "entire", "cohort", "was", "considered", ",", "only", "31", "%", "of", "the", "subjects", "had", "adequate", "samples", ".", "RPFNA", "was", "also", "attempted", "in", "all", "subjects", ",", "and", "sample", "retrieval", "rate", "was", "100", "%", ".", "Out", "of", "these", ",", "96", "%", "of", "the", "subjects", "had", "adequate", "samples", ".", "In", "DL", "samples", ",", "AH", "rate", "was", "3.7", "%", "was", "and", "hyperplasia", "(", "H", ")", "rate", "was", "11.1", "%", ".", "In", "RPFNA", "samples", ",", "AH", "rate", "was", "12.9", "%", ",", "and", "H", "rate", "was", "24.7", "%", ".", "Cytology", "findings", "in", "RPFNA", "samples", "correlated", "with", "age", ",", "menopausal", "status", ",", "and", "breast", "cancer", "risk", "category", "(", "previous", "history", "of", "lobular", "carcinoma", "in", "situ", ")", ".", "Both", "procedures", "were", "well", "tolerated", ",", "and", "no", "complications", "occurred", "among", "participants", ".", "Considering", "that", "the", "main", "end", "point", "for", "short", "-", "term", "prevention", "trials", "is", "the", "modulation", "of", "biomarkers", ",", "it", "is", "important", "to", "optimize", "adequate", "sample", "acquisition", ";", "therefore", ",", "RPFNA", "is", "a", "more", "practical", "option", "for", "future", "phase", "I", "and", "II", "breast", "cancer", "prevention", "trials", "compared", "with", "DL", "." ]

[ 0, 0, 17, 18, 0, 19, 20, 20, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 29, 30, 0, 0, 21, 22, 22, 22, 22, 0, 29, 30, 0, 0, 0, 0, 0, 21, 22, 0, 31, 32, 0, 0, 21, 22, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Impact", "of", "a", "tailored", "oral", "vitamin", "D", "supplementation", "regimen", "on", "serum", "25", "-hydroxyvitamin", "D", "levels", "in", "early", "breast", "cancer", "patients", ":", "a", "randomized", "phase", "III", "study", ".", "A", "minority", "of", "early", "breast", "cancer", "(", "EBC", ")", "patients", "treated", "with", "adjuvant", "or", "neoadjuvant", "chemotherapy", "have", "sufficient", "baseline", "vitamin", "D", "(", "vitD", ")", "level", ".", "This", "randomized", "phase", "III", "study", "assessed", "the", "safety", "and", "efficacy", "of", "a", "tailored", ",", "high", "-", "dose", ",", "oral", "vitD", "supplementation", "in", "restoring", "a", "normal", "25", "-hydroxy", "vitD", "(", "25", "OHD", ")", "level", "in", "this", "population", ".", "Participants", "received", "a", "6", "-month", "conventional", "(", "C", ")", "vitD", "and", "calcium", "supplementation", "or", "a", "6", "-month", "high", "-", "dose", "oral", "vitD", "regimen", "tailored", "on", "the", "deficiency", "(", "T", ")", "and", "a", "conventional", "calcium", "supplementation", ".", "The", "primary", "end", "point", "was", "the", "6", "-month", "percentage", "of", "25", "OHD", "serum", "level", "normalization", ".", "A", "total", "of", "215", "patients", "including", "197", "patients", "with", "vitD", "deficiency", "were", "recruited", ",", "and", "195", "patients", "were", "randomized", "(", "T", ",", "100", ";", "C", ",", "95", ")", ".", "Compliance", "to", "the", "daily", "oral", "supplementation", "was", "68.4", "%", "and", "67", "%", "in", "the", "C", "and", "T", "arms", ",", "respectively", ".", "Discontinuous", "high", "-", "dose", "vitD", "compliance", "appeared", "higher", "in", "the", "T", "arm", "(", "77", "%", ")", ".", "At", "6", "months", ",", "more", "patients", "presented", "with", "a", "normalized", "vitD", "level", "in", "the", "T", "arm", "(", "30", "%", "versus", "12.6", "%", ";", "P", "=", "0.003", ")", ".", "Supplementation", "was", "well", "tolerated", ",", "and", "no", "significant", "difference", "in", "the", "treatment", "-", "related", "toxicity", "between", "the", "two", "arms", "was", "reported", ".", "Fifty", "-", "two", "patients", "without", "vitD", "normalization", "from", "the", "C", "arm", "switched", "to", "the", "T", "arm", "after", "6", "months", ".", "At", "12", "months", ",", "44", "%", "of", "these", "patients", "achieved", "vitD", "normalization", ".", "A", "tailored", "high", "-", "dose", "oral", "vitD", "supplementation", "safely", "allows", "a", "higher", "percentage", "of", "the", "serum", "25", "OHD", "level", "normalization", "compared", "with", "a", "conventional", "regimen", "in", "chemotherapy", "-", "treated", "EBC", "patients", ".", "As", "compliance", "to", "a", "daily", "oral", "supplementation", "remains", "poor", "in", "this", "setting", ",", "an", "adaptation", "of", "the", "treatment", "schedule", "is", "warranted", ".", "NCT", "01480869", "." ]

[ 0, 0, 0, 0, 0, 17, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 20, 20, 20, 20, 20, 20, 20, 20, 0, 0, 17, 18, 18, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 5, 0, 0, 21, 22, 22, 22, 22, 22, 0, 31, 32, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 31, 32, 32, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Longitudinal", "impact", "of", "yoga", "on", "chemotherapy", "-", "related", "cognitive", "impairment", "and", "quality", "of", "life", "in", "women", "with", "early", "stage", "breast", "cancer", ":", "a", "case", "series", ".", "Adjuvant", "chemotherapy", "for", "women", "with", "breast", "cancer", "has", "significantly", "improved", "the", "cure", "rate", ";", "however", ",", "it", "has", "been", "associated", "with", "chemotherapy", "-", "related", "cognitive", "impact", "(", "CRCI", ")", ".", "The", "literature", "provides", "preliminary", "support", "for", "the", "feasibility", "and", "efficacy", "of", "yoga", "interventions", "for", "the", "general", "cancer", "population", ",", "however", ",", "controlled", "trials", "are", "scarce", "and", "no", "studies", "have", "examined", "the", "effect", "of", "yoga", "on", "cognition", "for", "women", "with", "breast", "cancer", "during", "chemotherapy", ".", "This", "case", "series", "aims", "to", "identify", "the", "impact", "of", "yoga", "on", "measures", "of", "cognition", ",", "functional", "outcomes", ",", "and", "quality", "of", "life", "(", "QOL", ")", "for", "breast", "cancer", "survivors", "(", "BCS", ")", ".", "Four", "women", "with", "a", "diagnosis", "of", "early", "-", "stage", "breast", "cancer", "prior", "to", "chemotherapy", "treatment", "were", "administered", "the", "following", "physiologic", "measures", "at", "baseline", ",", "6", ",", "and", "12", "weeks", "during", "chemotherapy", ",", "and", "at", "one", "and", "three", "months", "after", "the", "conclusion", "of", "the", "study", ":", "Functional", "Reach", "test", "(", "balance", ")", "and", "Sit", "and", "Reach", "test", "(", "flexibility", ")", ",", "and", "QOL", ",", "POMS", "(", "Mood", ")", "and", "FACT", "-", "B", "(", "QOL", ")", ",", "at", "baseline", ".", "Primary", "outcomes", "of", "cognition", "were", "measured", "with", "the", "Perceived", "Cognition", "Questionnaire", "(", "PCQ", ")", "and", "CogState", ",", "a", "computerized", "measurement", "of", "cognition", ".", "Women", "attended", "an", "Iyengar", "-", "inspired", "yoga", "program", "twice", "a", "week", "for", "12", "weeks", ".", "Qualitative", "questionnaires", "were", "administered", "after", "the", "completion", "of", "the", "study", "to", "determine", "perceived", "benefits", "and", "challenges", "of", "the", "yoga", "program", ".", "Four", "women", "with", "Stage", "II", "breast", "cancer", "ranged", "in", "age", "from", "44", "-", "65", "years", ".", "CogState", "computerized", "testing", "showed", "changes", "in", "varying", "domains", "of", "cognition", "through", "treatment", "and", "follow", "-", "up", ".", "Improved", "balance", ",", "flexibility", ",", "and", "QOL", "were", "also", "noted", "over", "time", ".", "No", "adverse", "events", "were", "observed", ".", "Analysis", "of", "qualitative", "data", "revealed", "the", "yoga", "classes", "were", "helpful", "and", "subjects", "continued", "the", "practice", "elements", "of", "yoga", "including", "relaxation", ",", "breathing", ",", "and", "stretching", ".", "The", "most", "challenging", "aspect", "of", "the", "study", "was", "physical", "limitations", "due", "to", "various", "medical", "complications", "and", "included", "fatigue", ",", "decreased", "range", "of", "motion", ",", "and", "pain", ".", "This", "case", "series", "suggests", "that", "yoga", "may", "impact", "various", "aspects", "of", "cognition", "during", "and", "after", "chemotherapy", "administration", "as", "noted", "through", "quantitative", "measures", ".", "Women", "describe", "yoga", "as", "improving", "various", "domains", "of", "QOL", "through", "the", "treatment", "trajectory", ".", "This", "mind", "-", "body", "intervention", "may", "stave", "off", "CRCI", ";", "however", ",", "further", "investigation", "is", "needed", "for", "additional", "randomized", "controlled", "trials", "on", "the", "effects", "of", "yoga", "on", "cognition", "for", "women", "with", "breast", "cancer", "undergoing", "adjuvant", "chemotherapy", "treatment", "." ]

[ 0, 0, 0, 17, 0, 13, 14, 14, 14, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "single", "-", "session", "acceptance", "and", "commitment", "therapy", "intervention", "among", "women", "undergoing", "surgery", "for", "breast", "cancer", ":", "A", "randomized", "pilot", "trial", "to", "reduce", "persistent", "postsurgical", "pain", ".", "Oncologic", "breast", "surgeries", "carry", "a", "risk", "for", "persistent", "postsurgical", "pain", ".", "This", "study", "was", "a", "randomized", "pilot", "and", "feasibility", "study", "of", "a", "single", "-", "session", "Acceptance", "and", "Commitment", "Therapy", "(", "ACT", ")", "intervention", "compared", "with", "treatment", "as", "usual", "among", "women", "undergoing", "surgery", "for", "breast", "cancer", "or", "ductal", "carcinoma", "in", "situ", ".", "Participants", "were", "recruited", "via", "letter", "of", "invitation", "and", "follow", "-", "up", "phone", "call", "from", "a", "single", "site", "in", "the", "United", "States", "from", "2015", "to", "2017", ".", "Participants", "were", "at", "risk", "for", "persistent", "postsurgical", "pain", ",", "based", "on", "young", "age", "(", "<", "50", ")", ",", "a", "preexisting", "chronic", "pain", "condition", ",", "or", "elevated", "anxiety", ",", "depression", ",", "or", "pain", "catastrophizing", ".", "The", "54", "participants", "were", "female", "with", "a", "mean", "age", "of", "52.91", "years", "(", "SD=", "11.80", ")", ".", "At", "3", "-month", "postsurgery", ",", "11", "%", "of", "the", "sample", "reported", "moderate", "-", "severe", "pain", "(", ">", "3", "on", "a", "0", "-", "10", "numeric", "rating", "scale", ")", "in", "the", "operative", "breast", "or", "with", "arm", "movement", ".", "Written", "qualitative", "responses", "indicated", "that", "the", "majority", "of", "participants", "who", "received", "the", "intervention", "understood", "the", "concepts", "presented", "and", "reported", "continued", "practice", "of", "exercises", "learned", "in", "the", "session", ".", "The", "between", "group", "effect", "sizes", "for", "moderate", "-", "severe", "pain", "and", "elevated", "anxiety", "at", "3", "-month", "post", "-", "surgery", "were", "small", "(", "Phi=", "0.08", "and", "0.16", ",", "respectively", ")", ".", "The", "between", "group", "effect", "sizes", "for", "depression", ",", "pain", "acceptance", ",", "and", "pain", "catastrophizing", "at", "3", "-month", "postsurgery", "were", "minimal", ".", "This", "study", "found", "small", "positive", "effects", "on", "postsurgical", "pain", "and", "anxiety", "for", "a", "single", "-", "session", "ACT", "intervention", "among", "women", "with", "breast", "cancer", ".", "This", "study", "supports", "the", "use", "of", "ACT", "with", "this", "population", "." ]

[ 0, 0, 0, 0, 17, 18, 18, 18, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 13, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 16, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Accelerated", "partial", "breast", "irradiation", "using", "intensity", "-", "modulated", "radiotherapy", "versus", "whole", "breast", "irradiation", ":", "5", "-year", "survival", "analysis", "of", "a", "phase", "3", "randomised", "controlled", "trial", ".", "Accelerated", "partial", "breast", "irradiation", "(", "APBI", ")", "has", "been", "introduced", "as", "an", "alternative", "treatment", "method", "for", "selected", "patients", "with", "early", "stage", "breast", "cancer", "(", "BC", ")", ".", "Intensity", "-", "modulated", "radiotherapy", "(", "IMRT", ")", "has", "the", "theoretical", "advantage", "of", "a", "further", "increase", "in", "dose", "conformity", "compared", "with", "three", "-", "dimensional", "techniques", ",", "with", "more", "normal", "tissue", "sparing", ".", "The", "aim", "of", "this", "randomised", "trial", "is", "to", "compare", "the", "local", "recurrence", "and", "survival", "of", "APBI", "using", "the", "IMRT", "technique", "after", "breast", "-", "conserving", "surgery", "to", "conventional", "whole", "-", "breast", "irradiation", "(", "WBI", ")", "in", "early", "stage", "BC", ".", "This", "study", "was", "performed", "at", "the", "University", "of", "Florence", "(", "Florence", ",", "Italy", ")", ".", "Women", "aged", "more", "than", "40", "years", "affected", "by", "early", "BC", ",", "with", "a", "maximum", "pathological", "tumour", "size", "of", "25", "mm", ",", "were", "randomly", "assigned", "in", "a", "1", ":1", "ratio", "to", "receive", "either", "WBI", "or", "APBI", "using", "IMRT", ".", "Patients", "in", "the", "APBI", "arm", "received", "a", "total", "dose", "of", "30", "Gy", "to", "the", "tumour", "bed", "in", "five", "daily", "fractions", ".", "The", "WBI", "arm", "received", "50", "Gy", "in", "25", "fractions", ",", "followed", "by", "a", "boost", "on", "the", "tumour", "bed", "of", "10", "Gy", "in", "five", "fractions", ".", "The", "primary", "end", "-", "point", "was", "occurrence", "of", "ipsilateral", "breast", "tumour", "recurrences", "(", "IBTRs", ")", ";", "the", "main", "analysis", "was", "by", "intention", "-", "to", "-", "treat", ".", "This", "trial", "is", "registered", "with", "ClinicalTrials.gov", ",", "number", "NCT", "02104895", ".", "A", "total", "of", "520", "patients", "were", "randomised", "(", "260", "to", "external", "WBI", "and", "260", "to", "APBI", "with", "IMRT", ")", "between", "March", "2005", "and", "June", "2013", ".", "At", "a", "median", "follow", "-", "up", "of", "5.0", "years", "(", "Interquartile", "Range", "(", "IQR", ")", "3.4", "-", "7.0", ")", ",", "the", "IBTR", "rate", "was", "1.5", "%", "(", "three", "cases", ")", "in", "the", "APBI", "group", "(", "95", "%", "confidence", "interval", "(", "CI", ")", "0.1", "-", "3.0", ")", "and", "in", "the", "WBI", "group", "(", "three", "cases", ";", "95", "%", "CI", "0.0", "-", "2.8", ")", ".", "No", "significant", "difference", "emerged", "between", "the", "two", "groups", "(", "log", "rank", "test", "p=", "0.86", ")", ".", "We", "identified", "seven", "deaths", "in", "the", "WBI", "group", "and", "only", "one", "in", "the", "APBI", "group", "(", "p=", "0.057", ")", ".", "The", "5", "-year", "overall", "survival", "was", "96.6", "%", "for", "the", "WBI", "group", "and", "99.4", "%", "for", "the", "APBI", "group", ".", "The", "APBI", "group", "presented", "significantly", "better", "results", "considering", "acute", "(", "p=", "0.0001", ")", ",", "late", "(", "p=", "0.004", ")", ",", "and", "cosmetic", "outcome", "(", "p=", "0.045", ")", ".", "To", "our", "knowledge", ",", "this", "is", "the", "first", "randomised", "study", "using", "the", "IMRT", "technique", "for", "APBI", "delivery", ".", "No", "significant", "difference", "in", "terms", "of", "IBTR", "and", "overall", "survival", "was", "observed", "between", "the", "two", "arms", ".", "APBI", "displayed", "a", "significantly", "better", "toxicity", "profile", "." ]

[ 17, 18, 18, 18, 0, 0, 0, 0, 0, 0, 19, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 5, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 25, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 27, 21, 0, 0, 0, 0, 0, 0, 25, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 31, 32, 0, 0, 0, 0, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Effect", "of", "topical", "microporous", "polysaccharide", "hemospheres", "on", "the", "duration", "and", "amount", "of", "fluid", "drainage", "following", "mastectomy", ":", "a", "prospective", "randomized", "clinical", "trial", ".", "Seroma", "formation", "is", "the", "most", "common", "complication", "after", "mastectomy", "and", "places", "patients", "at", "risk", "of", "associated", "morbidities", ".", "Microporous", "polysaccharide", "hemospheres", "(", "MPH", ")", "consists", "of", "hydrophilic", ",", "plant", "based", ",", "polysaccharide", "particles", "and", "is", "currently", "used", "as", "an", "absorbable", "hemostatic", "agent", ".", "An", "animal", "model", "evaluating", "MPH", "and", "seroma", "formation", "after", "mastectomy", "with", "axillary", "lymph", "node", "dissection", "showed", "a", "significant", "decrease", "in", "seroma", "volume", ".", "Study", "aim", "was", "to", "evaluate", "topical", "MPH", "on", "the", "risk", "of", "post", "-", "mastectomy", "seroma", "formation", "as", "measured", "by", "total", "drain", "output", "and", "total", "drain", "days", ".", "Prospective", "randomized", "single", "-", "blinded", "clinical", "trial", "of", "patients", "undergoing", "mastectomy", "for", "the", "treatment", "of", "breast", "cancer", ".", "MPH", "was", "applied", "to", "the", "surgical", "site", "in", "the", "study", "group", "and", "no", "application", "in", "the", "control", "group", ".", "Fifty", "patients", "were", "enrolled", ";", "eight", "were", "excluded", "due", "to", "missing", "data", ".", "Forty", "-", "two", "patients", "were", "evaluated", ",", "control", "(", "n", "=", "21", ")", "vs.", "MPH", "(", "n", "=", "21", ")", ".", "No", "difference", "was", "identified", "between", "the", "two", "groups", "regarding", "demographics", ",", "tumor", "stage", ",", "total", "drain", "days", ",", "total", "drain", "output", ",", "number", "of", "clinic", "visits", ",", "or", "complication", "rates", ".", "On", "a", "subset", "analysis", ",", "body", "mass", "index", "(", "BMI", ")", "greater", "than", "30", "was", "identified", "as", "an", "independent", "risk", "factor", "for", "high", "drain", "output", ".", "Post", "hoc", "analyses", "of", "MPH", "controlling", "for", "BMI", "also", "revealed", "no", "statistical", "difference", ".", "Unlike", "the", "data", "presented", "in", "an", "animal", "model", ",", "no", "difference", "was", "demonstrated", "in", "the", "duration", "and", "quantity", "of", "serosanguinous", "drainage", "related", "to", "the", "use", "of", "MPH", "in", "patients", "undergoing", "mastectomy", "for", "the", "treatment", "of", "breast", "cancer", ".", "BMI", "greater", "than", "30", "was", "identified", "as", "an", "independent", "risk", "factor", "for", "high", "drain", "output", "and", "this", "risk", "was", "not", "affected", "by", "MPH", "use", ".", "NCT", "03647930", ",", "retrospectively", "registered", "08", "/", "2018", "." ]

[ 0, 0, 17, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 13, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 20, 20, 20, 20, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Prevention", "of", "pegfilgrastim", "-", "induced", "bone", "pain", ":", "a", "phase", "III", "double", "-", "blind", "placebo", "-", "controlled", "randomized", "clinical", "trial", "of", "the", "university", "of", "rochester", "cancer", "center", "clinical", "community", "oncology", "program", "research", "base", ".", "Pegfilgrastim", "-", "induced", "bone", "pain", "is", "a", "significant", "clinical", "problem", "that", "may", "result", "in", "discontinuation", "of", "pegfilgrastim", "and", "lead", "to", "less", "effective", "chemotherapy", "dosing", ".", "Interventions", "for", "pegfilgrastim", "-", "induced", "bone", "pain", "are", "needed", ".", "The", "University", "of", "Rochester", "Cancer", "Center", "Clinical", "Community", "Oncology", "Program", "Research", "Base", "randomly", "assigned", "510", "patients", "at", "17", "sites", "to", "receive", "either", "naproxen", "(", "500", "mg", "two", "times", "per", "day", ")", "or", "placebo", "on", "the", "day", "of", "pegfilgrastim", "administration", ",", "continuing", "for", "5", "to", "8", "days", "after", "pegfilgrastim", ".", "Patients", "recorded", "pain", "severity", "(", "using", "a", "scale", "of", "0", "to", "10", ")", "and", "duration", "in", "daily", "diaries", ".", "The", "primary", "outcome", "measure", "was", "the", "area", "under", "the", "curve", "(", "AUC", ")", "for", "pain", "for", "days", "1", "through", "5", ".", "Secondary", "outcome", "measures", "included", "the", "identification", "of", "risk", "factors", "for", "the", "development", "of", "pain", "and", "response", "to", "naproxen", ".", "Patients", "'", "mean", "age", "was", "55.6", "years", "and", "86", "%", "were", "female", ".", "Sixty", "-", "eight", "percent", "of", "patients", "had", "breast", "cancer", "and", "10", "%", "had", "lung", "cancer", ".", "Pain", "reached", "its", "peak", "at", "3", "days", "for", "both", "groups", ".", "The", "mean", "AUC", "for", "pain", "was", "7.71", "for", "the", "placebo", "group", "and", "6.04", "for", "the", "naproxen", "group", "(", "P", "=", ".", "037", ")", ".", "Naproxen", "reduced", "maximum", "pain", "from", "3.40", "to", "2.59", "(", "P", "=", ".", "005", ")", ".", "Naproxen", "also", "reduced", "overall", "pain", "incidence", "from", "71.3", "%", "to", "61.1", "%", "(", "P", "=", ".", "020", ")", "and", "duration", "from", "2.40", "to", "1.92", "days", "(", "P", "=", ".", "009", ")", ".", "The", "reduction", "in", "severe", "pain", "(", ">", "5", "on", "a", "scale", "of", "1", "to", "10", ")", "from", "27.0", "%", "to", "19.2", "%", "was", "also", "significant", "(", "P", "=", ".", "048", ")", ".", "Risk", "factors", "could", "not", "be", "identified", "to", "predict", "incidence", ",", "severity", ",", "or", "ability", "to", "prevent", "pegfilgrastim", "-", "induced", "bone", "pain", ".", "Our", "phase", "III", "randomized", "placebo", "-", "controlled", "clinical", "trial", "demonstrated", "that", "naproxen", "at", "a", "dose", "of", "500", "mg", "twice", "per", "day", "is", "effective", "in", "reducing", "the", "incidence", "and", "severity", "of", "pegfilgrastim", "-", "induced", "bone", "pain", "." ]

[ 0, 0, 13, 14, 14, 14, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 17, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 0, 23, 24, 24, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 35, 0, 0, 0, 0, 0, 33, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 33, 0, 33, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 33, 34, 0, 33, 34, 0, 0, 0, 0, 0, 0, 0, 21, 0, 33, 0, 33, 34, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 33, 34, 0, 33, 34, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "ratio", "of", "positive", "to", "excised", "nodes", "identifies", "high", "-", "risk", "subsets", "and", "reduces", "inter", "-", "institutional", "differences", "in", "locoregional", "recurrence", "risk", "estimates", "in", "breast", "cancer", "patients", "with", "1", "-", "3", "positive", "nodes", ":", "an", "analysis", "of", "prospective", "data", "from", "British", "Columbia", "and", "the", "M.D", ".", "Anderson", "Cancer", "Center", ".", "To", "examine", "the", "power", "of", "the", "nodal", "ratio", "(", "NR", ")", "of", "positive", "/", "excised", "nodes", "in", "predicting", "postmastectomy", "locoregional", "recurrence", "(", "LRR", ")", "in", "patients", "with", "1", "-", "3", "positive", "nodes", "(", "N+", ")", "and", "in", "identifying", "cohorts", "at", "similar", "risk", "across", "independent", "data", "sets", ".", "Data", "from", "82", "patients", "with", "1", "-", "3", "N+", "treated", "without", "postmastectomy", "radiotherapy", "(", "PMRT", ")", "in", "the", "British", "Columbia", "(", "BC", ")", "randomized", "trial", "were", "compared", "with", "data", "from", "462", "patients", "treated", "without", "PMRT", "in", "prospective", "chemotherapy", "trials", "at", "the", "M.D", ".", "Anderson", "Cancer", "Center", "(", "MDACC", ")", ".", "Kaplan", "-", "Meier", "LRR", "curves", "were", "compared", "between", "centers", "using", "the", "absolute", "number", "of", "N+", "and", "nodal", "ratios", ".", "The", "median", "number", "of", "excised", "nodes", "was", "10", "in", "BC", "and", "16", "in", "MDACC", "(", "p", "<", "0.001", ")", ".", "Examining", "LRR", "by", "number", "of", "N+", ",", "the", "10", "-year", "LRR", "rate", "for", "patients", "with", "1", "-", "3", "N+", "was", "higher", "in", "BC", "compared", "with", "MDACC", "(", "21.5", "%", "vs.", "12.6", "%", ";", "p", "=", "0.02", ")", ".", "However", ",", "when", "examining", "LRR", "using", "NR", ",", "no", "differences", "were", "found", "between", "institutions", ".", "In", "patients", "with", "NR", "<", "or", "=", "0.20", ",", "the", "10", "-year", "LRR", "rate", "was", "17.7", "%", "BC", "vs.", "10.9", "%", "MDACC", "(", "p", "=", "0.27", ")", ".", "In", "patients", "with", "NR", ">", "or", "=", "0.20", ",", "the", "10", "-year", "LRR", "rate", "was", "28.7", "%", "BC", "vs.", "22.7", "%", "MDACC", "(", "p", "=", "0.32", ")", ".", "On", "Cox", "regression", "analysis", ",", "NR", "was", "a", "stronger", "prognostic", "factor", "compared", "with", "number", "of", "N", "+", ".", "In", "patients", "with", "1", "-", "3", "N+", ",", "evaluating", "nodal", "positivity", "using", "NR", "reduced", "inter", "-", "institutional", "differences", "in", "LRR", "estimates", "that", "may", "exist", "due", "to", "variations", "in", "numbers", "of", "nodes", "excised", ".", "Nodal", "ratio", ">", "0.20", "was", "associated", "with", "LRR", ">", "20", "%", ",", "warranting", "PMRT", "consideration", ".", "Nodal", "ratio", "may", "be", "useful", "for", "extrapolating", "data", "from", "prospective", "trials", "to", "clinical", "practices", "in", "which", "axillary", "staging", "extent", "vary", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 16, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 18, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 5, 0, 19, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 37, 0, 0, 0, 39, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 0, 21, 22, 22, 22, 0, 29, 30, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 0, 21, 22, 22, 22, 0, 29, 30, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Ovarian", "ablation", "or", "suppression", "in", "premenopausal", "early", "breast", "cancer", ":", "results", "from", "the", "international", "adjuvant", "breast", "cancer", "ovarian", "ablation", "or", "suppression", "randomized", "trial", ".", "Substantial", "survival", "benefits", "exist", "for", "patients", "with", "early", "-", "stage", "breast", "cancer", "who", "undergo", "treatment", "with", "single", "-", "modality", "tamoxifen", ",", "ovarian", "ablation", "or", "suppression", ",", "or", "chemotherapy", ".", "To", "determine", "whether", "additional", "benefits", "exist", "with", "combined", "treatment", ",", "the", "Adjuvant", "Breast", "Cancer", "(", "ABC", ")", "Trials", "were", "undertaken", ".", "The", "ABC", "Ovarian", "Ablation", "or", "Suppression", "Trial", "randomly", "assigned", "pre-", "and", "perimenopausal", "patients", "with", "early", "-", "stage", "breast", "cancer", "who", "were", "receiving", "prolonged", "(", "5", "years", ")", "tamoxifen", "treatment", "with", "or", "without", "chemotherapy", "to", "ovarian", "ablation", "or", "suppression", "(", "by", "oophorectomy", ",", "ovarian", "irradiation", ",", "or", "treatment", "with", "luteinizing", "hormone", "-", "releasing", "hormone", "agonist", ")", "versus", "no", "ovarian", "ablation", "or", "suppression", ".", "Trial", "endpoints", "included", "relapse", "-", "free", "and", "overall", "survival", ".", "Hazard", "ratios", "(", "HRs", ")", "were", "derived", "from", "Cox", "models", ",", "and", "all", "statistical", "tests", "were", "two", "-", "sided", ".", "Between", "1993", "and", "2000", ",", "2144", "(", "1063", "ovarian", "ablation", "or", "suppression", ",", "1081", "no", "ovarian", "ablation", "or", "suppression", ")", "patients", "were", "randomly", "assigned", ".", "A", "total", "of", "942", "(", "89", "%", ")", "received", "ovarian", "ablation", "or", "suppression", "as", "allocated", ".", "Overall", ",", "no", "evidence", "of", "a", "benefit", "for", "ovarian", "ablation", "or", "suppression", "was", "observed", "for", "relapse", "-", "free", "survival", "(", "relapse", "in", "the", "ovarian", "ablation", "/", "suppression", "versus", "no", "ovarian", "ablation", "/", "suppression", "group", ",", "290", "events", "versus", "306", "events", ",", "HR", "=", "0.95", ",", "95", "%", "confidence", "interval", "[", "CI", "]", "=", "0.81", "to", "1.12", ";", "P", "=", ".", "56", ")", "or", "overall", "survival", "(", "death", "from", "any", "cause", "in", "the", "ovarian", "ablation", "or", "suppression", "versus", "no", "ovarian", "ablation", "/", "suppression", "group", ",", "215", "events", "versus", "230", "events", ",", "HR", "=", "0.94", ",", "95", "%", "CI", "=", "0.78", "to", "1.13", ";", "P", "=", ".", "44", ")", ",", "nor", "were", "differences", "seen", "after", "adjustment", "for", "age", ",", "nodal", "status", ",", "or", "estrogen", "receptor", "(", "ER", ")", "status", ".", "Overall", ",", "no", "added", "effect", "of", "ovarian", "ablation", "or", "suppression", "was", "seen", "on", "relapse", "-", "free", "survival", "or", "overall", "survival", "of", "premenopausal", "women", "who", "were", "treated", "for", "early", "-", "stage", "breast", "cancer", ".", "However", ",", "the", "role", "of", "ovarian", "ablation", "or", "suppression", "in", "young", "(", "<", "40", "years", ")", "women", "with", "ER", "-", "positive", "tumors", ",", "especially", "those", "not", "receiving", "chemotherapy", ",", "requires", "further", "study", "." ]

[ 17, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 20, 20, 20, 0, 0, 0, 0, 23, 24, 24, 0, 23, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 3, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 25, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 25, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "NOLAN", ":", "a", "randomized", ",", "phase", "2", "study", "to", "estimate", "the", "effect", "of", "prophylactic", "naproxen", "or", "loratadine", "vs", "no", "prophylactic", "treatment", "on", "bone", "pain", "in", "patients", "with", "early", "-", "stage", "breast", "cancer", "receiving", "chemotherapy", "and", "pegfilgrastim", ".", "Mild", "-", "to", "-", "moderate", "bone", "pain", "is", "a", "commonly", "reported", "adverse", "event", "(", "AE", ")", "associated", "with", "pegfilgrastim", ".", "We", "evaluated", "the", "effect", "of", "prophylactic", "naproxen", "or", "loratadine", "vs", "no", "prophylactic", "treatment", "on", "pegfilgrastim", "-", "associated", "bone", "pain", ".", "In", "this", "open", "-", "label", "study", "(", "NCT", "01712009", ")", ",", "women", "≥", "18", "years", "of", "age", "with", "newly", "diagnosed", "stage", "I", "-", "III", "breast", "cancer", "and", "an", "ECOG", "performance", "status", "≤", "2", "who", "were", "planning", "≥", "4", "cycles", "of", "adjuvant", "or", "neoadjuvant", "chemotherapy", "with", "pegfilgrastim", "support", "starting", "in", "cycle", "1", "were", "randomized", "1", ":1", ":1", "to", "receive", "naproxen", ",", "loratadine", ",", "or", "no", "treatment", "to", "prevent", "pegfilgrastim", "-", "associated", "bone", "pain", ".", "The", "primary", "endpoint", "was", "all", "-", "grade", "bone", "pain", "in", "cycle", "1", "from", "AE", "reporting", ".", "Secondary", "endpoints", "included", "bone", "pain", "in", "cycles", "2", "-", "4", "and", "across", "all", "cycles", "from", "AE", "reporting", "and", "patient", "-", "reported", "bone", "pain", "by", "cycle", "and", "across", "all", "cycles", ".", "Six", "hundred", "patients", "were", "enrolled", ".", "Most", "patients", "(", "83.0", "%", ")", "were", "white", ",", "and", "mean", "(", "SD", ")", "age", "was", "54.2", "(", "11.1", ")", "years", ".", "The", "percentage", "of", "patients", "with", "all", "-", "grade", "bone", "pain", "in", "cycle", "1", "from", "AE", "reporting", "in", "the", "naproxen", ",", "loratadine", ",", "and", "no", "prophylaxis", "groups", "was", "40.3", ",", "42.5", ",", "and", "46.6", "%", ",", "respectively", ";", "differences", "between", "the", "treatment", "groups", "were", "not", "statistically", "significant", ".", "Maximum", ",", "mean", ",", "and", "area", "under", "the", "curve", "for", "patient", "-", "reported", "bone", "pain", "were", "consistently", "lower", "in", "the", "naproxen", "and", "loratadine", "groups", "than", "in", "the", "no", "prophylaxis", "group", ";", "some", "of", "these", "differences", "were", "significant", ".", "Loratadine", "was", "associated", "with", "fewer", "treatment", "-", "related", "AEs", "and", "discontinuations", "than", "naproxen", ".", "Given", "its", "tolerability", ",", "its", "ease", "of", "administration", ",", "and", "its", "potential", "benefit", ",", "treatment", "with", "loratadine", "should", "be", "considered", "to", "help", "prevent", "bone", "pain", "in", "patients", "receiving", "chemotherapy", "and", "pegfilgrastim", ".", "ClinicalTrials.gov", ";", "NCT", "01712009", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 18, 0, 19, 20, 20, 0, 13, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 11, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 0, 29, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Impact", "of", "aromatase", "inhibitor", "treatment", "on", "global", "gene", "expression", "and", "its", "association", "with", "antiproliferative", "response", "in", "ER+", "breast", "cancer", "in", "postmenopausal", "patients", ".", "Endocrine", "therapy", "reduces", "breast", "cancer", "mortality", "by", "40", "%", ",", "but", "resistance", "remains", "a", "major", "clinical", "problem", ".", "In", "this", "study", ",", "we", "sought", "to", "investigate", "the", "impact", "of", "aromatase", "inhibitor", "(", "AI", ")", "therapy", "on", "gene", "expression", "and", "identify", "gene", "modules", "representing", "key", "biological", "pathways", "that", "relate", "to", "early", "AI", "therapy", "resistance", ".", "Global", "gene", "expression", "was", "measured", "on", "pairs", "of", "core", "-", "cut", "biopsies", "taken", "at", "baseline", "and", "at", "surgery", "from", "254", "patients", "with", "ER", "-", "positive", "primary", "breast", "cancer", "randomised", "to", "receive", "2", "-week", "presurgical", "AI", "(", "n", "=", "198", ")", "or", "no", "presurgical", "treatment", "(", "control", "n", "=", "56", ")", "from", "the", "POETIC", "trial", ".", "Data", "from", "the", "AI", "group", "was", "adjusted", "to", "eliminate", "artefactual", "process", "-", "related", "changes", "identified", "in", "the", "control", "group", ".", "The", "response", "was", "assessed", "by", "changes", "in", "the", "proliferation", "marker", ",", "Ki", "67", ".", "High", "baseline", "ESR", "1", "expression", "associated", "with", "better", "AI", "response", "in", "HER", "2", "+", "tumours", "but", "not", "HER", "2", "-", "tumours", ".", "In", "HER", "2", "-", "tumours", ",", "baseline", "expression", "of", "48", "genes", "associated", "with", "poor", "antiproliferative", "response", "(", "p", "<", "0.005", ")", "including", "PERP", "and", "YWHAQ", ",", "the", "two", "most", "significant", ",", "and", "the", "transcription", "co", "-", "regulators", "(", "SAP", "130", ",", "HDAC", "4", ",", "and", "NCOA", "7", ")", "which", "were", "among", "the", "top", "16", "most", "significant", ".", "Baseline", "gene", "signature", "scores", "measuring", "cell", "proliferation", ",", "growth", "factor", "signalling", "(", "ERBB", "2", "-", "GS", ",", "RET", "/", "GDNF", "-", "GS", ",", "and", "IGF-", "1", "-", "GS", ")", ",", "and", "immune", "activity", "(", "STAT", "1", "-", "GS", ")", "were", "significantly", "higher", "in", "poor", "AI", "responders", ".", "Two", "weeks", "of", "AI", "caused", "downregulation", "of", "genes", "involved", "in", "cell", "proliferation", "and", "ER", "signalling", ",", "as", "expected", ".", "Signature", "scores", "of", "E", "2", "F", "activation", "and", "TP", "53", "dysfunction", "after", "2", "-week", "AI", "were", "associated", "with", "poor", "AI", "response", "in", "both", "HER", "2", "-", "and", "HER", "2", "+", "patients", ".", "There", "is", "a", "high", "degree", "of", "heterogeneity", "in", "adaptive", "mechanisms", "after", "as", "little", "as", "2", "-week", "AI", "therapy", ";", "however", ",", "all", "appear", "to", "converge", "on", "cell", "cycle", "regulation", ".", "Our", "data", "support", "the", "evaluation", "of", "whether", "an", "E", "2", "F", "signatures", "after", "short", "-", "term", "exposure", "to", "AI", "may", "identify", "those", "patients", "most", "likely", "to", "benefit", "from", "the", "early", "addition", "of", "CDK", "4", "/", "6", "inhibitors", ".", "ISRCTN", ",", "ISRCTN", "63882543", ",", "registered", "on", "18", "December", "2007", "." ]

[ 0, 0, 17, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 9, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 19, 20, 20, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Impact", "of", "Awake", "Breast", "Cancer", "Surgery", "on", "Postoperative", "Lymphocyte", "Responses", ".", "Surgical", "stress", "and", "anesthesia", "affect", "the", "patient", "'s", "immune", "system", ".", "Analysis", "of", "the", "lymphocyte", "response", "after", "breast", "-", "conserving", "surgery", "was", "conducted", "to", "investigate", "the", "differences", "between", "effects", "after", "general", "and", "local", "anesthesia", ".", "Fifty", "-", "six", "patients", "with", "breast", "cancer", "were", "enrolled", "for", "BCS", "through", "local", "or", "general", "anesthesia", ".", "Total", "leukocytes", ",", "total", "lymphocytes", ",", "lymphocyte", "-", "subsets", "including", "CD", "3", "+", ",", "CD", "19", "+", ",", "CD", "4", "+", ",", "CD", "8", "+", ",", "CD", "16", "+CD", "56", "+", "and", "CD", "4", "+", "/", "CD", "8", "+", "ratio", "was", "examined", "at", "baseline", "and", "on", "postoperative", "days", "1", ",", "2", "and", "3", ".", "Baseline", "data", "showed", "no", "statistical", "difference", "between", "the", "two", "groups", ".", "Within", "-", "group", "ANOVA", "test", "showed", "significant", "differences", "for", "total", "leukocyte", "count", "(", "p", "<", "0.001", ")", ",", "total", "lymphocyte", "count", "(", "p=", "0.009", ")", "and", "proportion", "of", "natural", "-", "killer", "cells", "(", "p=", "0.01", ")", "in", "the", "control", "group", ".", "Between", "-", "group", "analysis", "showed", "lower", "median", "values", "of", "total", "lymphocytes", "in", "the", "awake", "surgery", "group", "on", "postoperative", "days", "1", ",", "2", "and", "3", "(", "p=", "0.001", ",", "p=", "0.02", "and", "p=", "0.01", ",", "respectively", ")", "when", "compared", "to", "the", "control", "group", ".", "Patients", "who", "underwent", "surgery", "under", "general", "anesthesia", "had", "higher", "total", "lymphocyte", "counts", "on", "postoperative", "day", "2", "(", "p=", "0.04", ")", ".", "In", "this", "randomized", "study", ",", "breast", "-", "conserving", "surgery", "plus", "local", "anesthesia", "had", "a", "lower", "impact", "on", "postoperative", "lymphocyte", "response", "when", "compared", "to", "the", "same", "procedure", "performed", "under", "general", "anesthesia", "." ]

[ 0, 0, 17, 18, 18, 18, 0, 13, 14, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Effect", "of", "Acupuncture", "vs", "Sham", "Acupuncture", "or", "Waitlist", "Control", "on", "Joint", "Pain", "Related", "to", "Aromatase", "Inhibitors", "Among", "Women", "With", "Early", "-", "Stage", "Breast", "Cancer", ":", "A", "Randomized", "Clinical", "Trial", ".", "Musculoskeletal", "symptoms", "are", "the", "most", "common", "adverse", "effects", "of", "aromatase", "inhibitors", "and", "often", "result", "in", "therapy", "discontinuation", ".", "Small", "studies", "suggest", "that", "acupuncture", "may", "decrease", "aromatase", "inhibitor", "-", "related", "joint", "symptoms", ".", "To", "determine", "the", "effect", "of", "acupuncture", "in", "reducing", "aromatase", "inhibitor", "-", "related", "joint", "pain", ".", "Randomized", "clinical", "trial", "conducted", "at", "11", "academic", "centers", "and", "clinical", "sites", "in", "the", "United", "States", "from", "March", "2012", "to", "February", "2017", "(", "final", "date", "of", "follow", "-", "up", ",", "September", "5", ",", "2017", ")", ".", "Eligible", "patients", "were", "postmenopausal", "women", "with", "early", "-", "stage", "breast", "cancer", "who", "were", "taking", "an", "aromatase", "inhibitor", "and", "scored", "at", "least", "3", "on", "the", "Brief", "Pain", "Inventory", "Worst", "Pain", "(", "BPI", "-", "WP", ")", "item", "(", "score", "range", ",", "0", "-", "10", ";", "higher", "scores", "indicate", "greater", "pain", ")", ".", "Patients", "were", "randomized", "2", ":1", ":1", "to", "the", "true", "acupuncture", "(", "n", "=", "110", ")", ",", "sham", "acupuncture", "(", "n", "=", "59", ")", ",", "or", "waitlist", "control", "(", "n", "=", "57", ")", "group", ".", "True", "acupuncture", "and", "sham", "acupuncture", "protocols", "consisted", "of", "12", "acupuncture", "sessions", "over", "6", "weeks", "(", "2", "sessions", "per", "week", ")", ",", "followed", "by", "1", "session", "per", "week", "for", "6", "weeks", ".", "The", "waitlist", "control", "group", "did", "not", "receive", "any", "intervention", ".", "All", "participants", "were", "offered", "10", "acupuncture", "sessions", "to", "be", "used", "between", "weeks", "24", "and", "52", ".", "The", "primary", "end", "point", "was", "the", "6", "-week", "BPI", "-", "WP", "score", ".", "Mean", "6", "-week", "BPI", "-", "WP", "scores", "were", "compared", "by", "study", "group", "using", "linear", "regression", ",", "adjusted", "for", "baseline", "pain", "and", "stratification", "factors", "(", "clinically", "meaningful", "difference", "specified", "as", "2", "points", ")", ".", "Among", "226", "randomized", "patients", "(", "mean", "[", "SD", "]", "age", ",", "60.7", "[", "8.6", "]", "years", ";", "88", "%", "white", ";", "mean", "[", "SD", "]", "baseline", "BPI", "-", "WP", "score", ",", "6.6", "[", "1.5", "]", ")", ",", "206", "(", "91.1", "%", ")", "completed", "the", "trial", ".", "From", "baseline", "to", "6", "weeks", ",", "the", "mean", "observed", "BPI", "-", "WP", "score", "decreased", "by", "2.05", "points", "(", "reduced", "pain", ")", "in", "the", "true", "acupuncture", "group", ",", "by", "1.07", "points", "in", "the", "sham", "acupuncture", "group", ",", "and", "by", "0.99", "points", "in", "the", "waitlist", "control", "group", ".", "The", "adjusted", "difference", "for", "true", "acupuncture", "vs", "sham", "acupuncture", "was", "0.92", "points", "(", "95", "%", "CI", ",", "0.20", "-", "1.65", ";", "P", "=", ".", "01", ")", "and", "for", "true", "acupuncture", "vs", "waitlist", "control", "was", "0.96", "points", "(", "95", "%", "CI", ",", "0.24", "-", "1.67", ";", "P", "=", ".", "01", ")", ".", "Patients", "in", "the", "true", "acupuncture", "group", "experienced", "more", "grade", "1", "bruising", "compared", "with", "patients", "in", "the", "sham", "acupuncture", "group", "(", "47", "%", "vs", "25", "%", ";", "P", "=", ".", "01", ")", ".", "Among", "postmenopausal", "women", "with", "early", "-", "stage", "breast", "cancer", "and", "aromatase", "inhibitor", "-", "related", "arthralgias", ",", "true", "acupuncture", "compared", "with", "sham", "acupuncture", "or", "with", "waitlist", "control", "resulted", "in", "a", "statistically", "significant", "reduction", "in", "joint", "pain", "at", "6", "weeks", ",", "although", "the", "observed", "improvement", "was", "of", "uncertain", "clinical", "importance", ".", "ClinicalTrials.gov", "Identifier", ":", "NCT", "01535066", "." ]

[ 0, 0, 17, 0, 17, 18, 0, 19, 20, 0, 13, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 16, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 0, 0, 0, 11, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 33, 34, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 33, 34, 0, 0, 0, 0, 0, 0, 0, 0, 35, 36, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 21, 22, 22, 22, 22, 0, 33, 34, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 35, 36, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Testing", "the", "effects", "of", "narrative", "and", "play", "on", "physical", "activity", "among", "breast", "cancer", "survivors", "using", "mobile", "apps", ":", "study", "protocol", "for", "a", "randomized", "controlled", "trial", ".", "Physical", "activity", "reduces", "risk", "for", "numerous", "negative", "health", "outcomes", ",", "but", "postmenopausal", "breast", "cancer", "survivors", "do", "not", "reach", "recommended", "levels", ".", "Many", "interventions", "encourage", "self", "-", "monitoring", "of", "steps", ",", "which", "can", "increase", "physical", "activity", "in", "the", "short", "term", ".", "However", ",", "these", "interventions", "appear", "insufficient", "to", "increase", "motivation", "for", "sustained", "change", ".", "There", "is", "a", "need", "for", "innovative", "strategies", "to", "increase", "physical", "activity", "motivation", "in", "this", "population", ".", "Narratives", "are", "uniquely", "persuasive", ",", "and", "video", "games", "show", "promise", "for", "increasing", "motivation", ".", "This", "study", "will", "determine", "the", "effectiveness", "of", "an", "intervention", "that", "combines", "narrative", "and", "gaming", "to", "encourage", "sustained", "physical", "activity", ".", "SMARTGOAL", "(", "Self", "-", "Monitoring", "Activity", ":", "a", "Randomized", "Trial", "of", "Game", "-", "Oriented", "AppLications", ")", "is", "a", "randomized", "controlled", "intervention", "trial", ".", "The", "intervention", "period", "is", "six", "months", ",", "followed", "by", "a", "six", "month", "maintenance", "period", ".", "Participants", "(", "overweight", ",", "sedentary", "postmenopausal", "breast", "cancer", "survivors", "aged", "45", "-", "75", ")", "will", "be", "randomized", "to", "a", "self", "-", "monitoring", "group", "or", "an", "enhanced", "narrative", "game", "group", ".", "The", "self", "-", "monitoring", "group", "will", "be", "encouraged", "to", "use", "a", "mobile", "application", "for", "self", "-", "monitoring", "and", "feedback", "and", "will", "receive", "15", "counseling", "phone", "calls", "emphasizing", "self", "-", "regulation", ".", "The", "narrative", "game", "group", "will", "be", "encouraged", "to", "use", "a", "mobile", "application", "that", "includes", "self", "-", "monitoring", "and", "feedback", "as", "well", "as", "a", "narrative", "-", "based", "active", "video", "game", ".", "The", "15", "calls", "for", "this", "group", "will", "emphasize", "concepts", "related", "to", "the", "game", "storyline", ".", "Counseling", "calls", "in", "both", "groups", "will", "occur", "weekly", "in", "months", "1", "-", "3", "and", "monthly", "in", "months", "4", "-", "6", ".", "No", "counseling", "calls", "will", "occur", "after", "month", "6", ",", "but", "both", "groups", "will", "be", "encouraged", "to", "continue", "using", "their", "apps", ".", "The", "primary", "outcome", "of", "the", "study", "is", "minutes", "of", "moderate", "to", "vigorous", "physical", "activity", "at", "six", "months", ".", "Other", "objectively", "measured", "outcomes", "include", "fitness", "and", "physical", "function", ".", "Self", "-", "reported", "outcomes", "include", "quality", "of", "life", ",", "depression", ",", "and", "motivation", ".", "This", "protocol", "will", "result", "in", "implementation", "and", "evaluation", "of", "two", "technology", "-", "based", "physical", "activity", "interventions", "among", "breast", "cancer", "survivors", ".", "Both", "interventions", "hold", "promise", "for", "broad", "dissemination", ".", "Understanding", "the", "potential", "benefit", "of", "adding", "narrative", "and", "game", "elements", "to", "interventions", "will", "provide", "critical", "information", "to", "interventionists", ",", "researchers", ",", "clinicians", ",", "and", "policymakers", ".", "This", "study", "is", "uniquely", "suited", "to", "investigate", "not", "just", "whether", "but", "how", "and", "why", "game", "elements", "may", "improve", "breast", "cancer", "survivors", "'", "health", ".", "clinicaltrials.gov", "NCT", "02341235", "(", "January", "9", ",", "2015", ")", "." ]

[ 0, 0, 0, 0, 17, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 19, 20, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 21, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Anastrozole", "versus", "tamoxifen", "for", "the", "prevention", "of", "locoregional", "and", "contralateral", "breast", "cancer", "in", "postmenopausal", "women", "with", "locally", "excised", "ductal", "carcinoma", "in", "situ", "(", "IBIS", "-", "II", "DCIS", ")", ":", "a", "double", "-", "blind", ",", "randomised", "controlled", "trial", ".", "Third", "-", "generation", "aromatase", "inhibitors", "are", "more", "effective", "than", "tamoxifen", "for", "preventing", "recurrence", "in", "postmenopausal", "women", "with", "hormone", "-", "receptor", "-", "positive", "invasive", "breast", "cancer", ".", "However", ",", "it", "is", "not", "known", "whether", "anastrozole", "is", "more", "effective", "than", "tamoxifen", "for", "women", "with", "hormone", "-", "receptor", "-", "positive", "ductal", "carcinoma", "in", "situ", "(", "DCIS", ")", ".", "Here", ",", "we", "compare", "the", "efficacy", "of", "anastrozole", "with", "that", "of", "tamoxifen", "in", "postmenopausal", "women", "with", "hormone", "-", "receptor", "-", "positive", "DCIS", ".", "In", "a", "double", "-", "blind", ",", "multicentre", ",", "randomised", "placebo", "-", "controlled", "trial", ",", "we", "recruited", "women", "who", "had", "been", "diagnosed", "with", "locally", "excised", ",", "hormone", "-", "receptor", "-", "positive", "DCIS", ".", "Eligible", "women", "were", "randomly", "assigned", "in", "a", "1", ":1", "ratio", "by", "central", "computer", "allocation", "to", "receive", "1", "mg", "oral", "anastrozole", "or", "20", "mg", "oral", "tamoxifen", "every", "day", "for", "5", "years", ".", "Randomisation", "was", "stratified", "by", "major", "centre", "or", "hub", "and", "was", "done", "in", "blocks", "(", "six", ",", "eight", ",", "or", "ten", ")", ".", "All", "trial", "personnel", ",", "participants", ",", "and", "clinicians", "were", "masked", "to", "treatment", "allocation", "and", "only", "the", "trial", "statistician", "had", "access", "to", "treatment", "allocation", ".", "The", "primary", "endpoint", "was", "all", "recurrence", ",", "including", "recurrent", "DCIS", "and", "new", "contralateral", "tumours", ".", "All", "analyses", "were", "done", "on", "a", "modified", "intention", "-", "to", "-", "treat", "basis", "(", "in", "all", "women", "who", "were", "randomised", "and", "did", "not", "revoke", "consent", "for", "their", "data", "to", "be", "included", ")", "and", "proportional", "hazard", "models", "were", "used", "to", "compute", "hazard", "ratios", "and", "corresponding", "confidence", "intervals", ".", "This", "trial", "is", "registered", "at", "the", "ISRCTN", "registry", ",", "number", "ISRCTN", "37546358", ".", "Between", "March", "3", ",", "2003", ",", "and", "Feb", "8", ",", "2012", ",", "we", "enrolled", "2980", "postmenopausal", "women", "from", "236", "centres", "in", "14", "countries", "and", "randomly", "assigned", "them", "to", "receive", "anastrozole", "(", "1449", "analysed", ")", "or", "tamoxifen", "(", "1489", "analysed", ")", ".", "Median", "follow", "-", "up", "was", "7", "·", "2", "years", "(", "IQR", "5", "·", "6", "-", "8", "·", "9", ")", ",", "and", "144", "breast", "cancer", "recurrences", "were", "recorded", ".", "We", "noted", "no", "statistically", "significant", "difference", "in", "overall", "recurrence", "(", "67", "recurrences", "for", "anastrozole", "vs", "77", "for", "tamoxifen", ";", "HR", "0", "·", "89", "[", "95", "%", "CI", "0", "·", "64", "-", "1", "·", "23", "]", ")", ".", "The", "non", "-", "inferiority", "of", "anastrozole", "was", "established", "(", "upper", "95", "%", "CI", "<", "1", "·", "25", ")", ",", "but", "its", "superiority", "to", "tamoxifen", "was", "not", "(", "p=", "0", "·", "49", ")", ".", "A", "total", "of", "69", "deaths", "were", "recorded", "(", "33", "for", "anastrozole", "vs", "36", "for", "tamoxifen", ";", "HR", "0", "·", "93", "[", "95", "%", "CI", "0", "·", "58", "-", "1", "·", "50", "]", ",", "p=", "0", "·", "78", ")", ",", "and", "no", "specific", "cause", "was", "more", "common", "in", "one", "group", "than", "the", "other", ".", "The", "number", "of", "women", "reporting", "any", "adverse", "event", "was", "similar", "between", "anastrozole", "(", "1323", "women", ",", "91", "%", ")", "and", "tamoxifen", "(", "1379", "women", ",", "93", "%", ")", ";", "the", "side", "-", "effect", "profiles", "of", "the", "two", "drugs", "differed", ",", "with", "more", "fractures", ",", "musculoskeletal", "events", ",", "hypercholesterolaemia", ",", "and", "strokes", "with", "anastrozole", "and", "more", "muscle", "spasm", ",", "gynaecological", "cancers", "and", "symptoms", ",", "vasomotor", "symptoms", ",", "and", "deep", "vein", "thromboses", "with", "tamoxifen", ".", "No", "clear", "efficacy", "differences", "were", "seen", "between", "the", "two", "treatments", ".", "Anastrozole", "offers", "another", "treatment", "option", "for", "postmenopausal", "women", "with", "hormone", "-", "receptor", "-", "positive", "DCIS", ",", "which", "may", "be", "be", "more", "appropriate", "for", "some", "women", "with", "contraindications", "for", "tamoxifen", ".", "Longer", "follow", "-", "up", "will", "be", "necessary", "to", "fully", "evaluate", "treatment", "differences", ".", "Cancer", "Research", "UK", ",", "National", "Health", "and", "Medical", "Research", "Council", "Australia", ",", "Breast", "Cancer", "Research", "Fund", ",", "AstraZeneca", ",", "Sanofi", "Aventis", "." ]

[ 17, 0, 19, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 25, 0, 0, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 25, 0, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 25, 0, 0, 29, 30, 0, 0, 0, 0, 27, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 21, 22, 0, 21, 0, 0, 21, 0, 0, 0, 0, 21, 22, 0, 21, 22, 22, 22, 0, 21, 22, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Randomized", "phase", "III", "trial", "of", "adjuvant", "epirubicin", "followed", "by", "cyclophosphamide", ",", "methotrexate", ",", "and", "5", "-fluorouracil", "(", "CMF", ")", "versus", "CMF", "followed", "by", "epirubicin", "in", "patients", "with", "node", "-", "negative", "or", "1", "-", "3", "node", "-", "positive", "rapidly", "proliferating", "breast", "cancer", ".", "Adjuvant", "cyclophosphamide", ",", "methotrexate", ",", "and", "5", "-fluorouracil", "(", "CMF", ")", "have", "proven", "highly", "effective", "in", "rapidly", "proliferating", "breast", "cancer", "(", "RPBC", ")", ".", "It", "has", "also", "been", "seen", "that", "sequential", "administration", "of", "doxorubicin", "and", "CMF", "is", "superior", "to", "their", "alternation", ",", "especially", "in", "indolent", "tumors", ".", "In", "a", "phase", "III", "study", ",", "we", "evaluated", "whether", "adjuvant", "epirubicin", "(", "E", ")", "followed", "by", "CMF", "is", "superior", "to", "the", "inverse", "sequence", "in", "RPBC", ".", "Patients", "with", "node", "-", "negative", "or", "1", "-", "3", "node", "-", "positive", "RPBC", "(", "Thymidine", "Labeling", "Index", ">", "3", "%", "or", "histological", "grade", "3", "or", "S", "-", "phase", ">", "10", "%", "or", "Ki", "67", ">", "20", "%", ")", "were", "randomized", "to", "receive", "E", "(", "100", "mg", "/", "m", "(", "2", ")", "i.", "v.", "d", "1", ",", "q", "21", "days", "for", "4", "cycles", ")", "followed", "by", "CMF", "(", "600", ",", "40", ",", "600", "mg", "/", "m", "(", "2", ")", "i.", "v.", "d", "1", "and", "8", ",", "q", "28", "days", "for", "4", "cycles", ")", "(", "E", "→", "CMF", ")", "or", "CMF", "followed", "by", "E", "(", "CMF", "→", "E", ")", "or", "CMF", "for", "6", "cycles", ".", "From", "November", "1997", "to", "December", "2004", ",", "1066", "patients", "were", "enrolled", ":", "E", "→", "CMF", "440", ",", "CMF", "→", "E", "438", ",", "and", "CMF", "188", ".", "At", "a", "median", "follow", "-", "up", "of", "69", "months", ",", "5", "-year", "OS", "was", "91", "%", "(", "95", "%", "CI", "88", "-", "94", ")", "for", "E", "→", "CMF", "and", "93", "%", "(", "95", "%", "CI", "90", "-", "95", ")", "for", "CMF", "→", "E", ",", "with", "adjusted", "hazard", "ratio", "of", "0.88", "(", "95", "%", "CI", "0.58", "-", "1.35", ")", ",", "and", "DFS", "was", "80", "%", "in", "both", "arms", ",", "with", "adjusted", "hazard", "ratio", "of", "0.99", "(", "95", "%", "CI", "0.73", "-", "1.33", ",", "Cox", "model", ")", ".", "Adverse", "events", "were", "similar", ",", "apart", "from", "a", "higher", "rate", "of", "neutropenia", "in", "the", "CMF", "→", "E", "arm", ".", "No", "important", "differences", "in", "clinical", "outcome", "were", "observed", "between", "the", "two", "different", "sequences", ",", "making", "both", "a", "valid", "option", "in", "early", "breast", "cancer", ".", "Further", "molecular", "characterization", "of", "the", "tumors", "might", "help", "to", "identify", "subgroups", "achieving", "higher", "benefit", "from", "either", "sequence", "." ]

[ 0, 0, 0, 0, 0, 17, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 0, 19, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 3, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "effect", "of", "transdermal", "estradiol", "or", "oral", "conjugated", "oestrogen", "and", "fenretinide", "versus", "placebo", "on", "haemostasis", "and", "cardiovascular", "risk", "biomarkers", "in", "a", "randomized", "breast", "cancer", "chemoprevention", "trial", ".", "We", "have", "previously", "reported", "the", "favourable", "effect", "of", "transdermal", "estradiol", "(", "E", "2", ")", ",", "relative", "to", "oral", "conjugated", "equine", "oestrogen", "(", "CEE", ")", ",", "on", "ultrasensitive", "C", "-", "reactive", "protein", "after", "12", "months", "of", "treatment", "in", "a", "retinoid", "-", "placebo", "controlled", "two", "-", "by", "-", "two", "randomized", "breast", "cancer", "prevention", "trial", "(", "Decensi", "A", "et", "al", "(", "2002", ")", "Circulation", "106", "10", "1224", "-", "8", ")", ".", "Here", ",", "we", "investigate", "the", "changes", "in", "lipids", "and", "clotting", "profile", "in", "patients", "of", "the", "same", "trial", ".", "Recent", "post", "-", "menopausal", "women", "were", "randomised", "to", "either", "oral", "CEE", "0.625", "mg", "/", "day", "and", "placebo", "(", "n", "=", "55", ")", ",", "CEE", "and", "fenretinide", "200", "mg", "/", "day", "(", "n", "=", "56", ")", ",", "transdermal", "E", "2", "50", "mg", "/", "day", "and", "placebo", "(", "n", "=", "59", ")", "or", "E", "2", "and", "fenretinide", "200", "mg", "/", "day", "(", "n", "=", "56", ")", ".", "Sequential", "medroxyprogesterone", "acetate", "10", "mg", "/", "day", "was", "given", "in", "each", "group", ".", "After", "12", "months", ",", "there", "was", "a", "statistically", "significant", "effect", "of", "the", "route", "of", "administration", "of", "hormone", "replacement", "therapy", "(", "HRT", ")", "on", "fibrinogen", "levels", ";", "the", "median", "percentage", "change", "being", "-", "5.7", "%", "with", "CEE", "and", "-", "1.1", "%", "with", "E", "2", "(", "p", "=", "0.012", ")", ".", "Total", "cholesterol", "decreased", "in", "all", "arms", "(", "p", "<", "0.0001", ")", ".", "HDL", "-", "C", "decreased", "significantly", "with", "transdermal", "E", "2", "(", "p", "=", "0.006", ")", "compared", "to", "oral", "CEE", "and", "with", "fenretinide", "relative", "to", "placebo", "(", "p", "<", "0.001", ")", ".", "Triglycerides", "exhibited", "an", "opposite", "modulation", "in", "the", "HRT", "route", ",", "with", "a", "21.4", "%", "median", "increase", "with", "oral", "CEE", "and", "an", "8.6", "%", "reduction", "with", "transdermal", "E", "2", "(", "p", "<", "0.0001", ")", ".", "Antithrombin", "-", "III", "showed", "a", "4", "%", "borderline", "significant", "reduction", "in", "the", "fenretinide", "arm", "relative", "to", "placebo", ",", "irrespective", "of", "the", "HRT", "administration", "route", "(", "p", "=", "0.055", ")", ".", "Our", "data", "indicate", "that", "transdermal", "E", "2", "may", "be", "preferable", "to", "oral", "CEE", "based", "on", "its", "safer", "cardiovascular", "risk", "profile", ".", "Fenretinide", "modified", "some", "cardiovascular", "risk", "biomarkers", "and", "confirmed", "a", "safer", "profile", "compared", "to", "other", "retinoids", "." ]

[ 0, 0, 0, 17, 18, 18, 18, 18, 18, 18, 18, 0, 19, 0, 13, 14, 14, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 37, 38, 38, 0, 0, 0, 37, 38, 38, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 37, 38, 0, 0, 0, 0, 0, 0, 0, 37, 38, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Combination", "of", "inositol", "and", "alpha", "lipoic", "acid", "in", "metabolic", "syndrome", "-", "affected", "women", ":", "a", "randomized", "placebo", "-", "controlled", "trial", ".", "Inositol", "has", "been", "reported", "to", "improve", "insulin", "sensitivity", "since", "it", "works", "as", "a", "second", "messenger", "achieving", "insulin", "-", "like", "effects", "on", "metabolic", "enzymes", ".", "The", "aim", "of", "this", "study", "was", "to", "evaluate", "the", "inositol", "and", "alpha", "lipoic", "acid", "combination", "effectiveness", "on", "metabolic", "syndrome", "features", "in", "postmenopausal", "women", "at", "risk", "of", "breast", "cancer", ".", "A", "six", "-", "month", "prospective", ",", "randomized", "placebo", "-", "controlled", "trial", "was", "carried", "out", "on", "a", "total", "of", "155", "postmenopausal", "women", "affected", "by", "metabolic", "syndrome", "at", "risk", "of", "breast", "cancer", ",", "the", "INOSIDEX", "trial", ".", "All", "women", "were", "asked", "to", "follow", "a", "low", "-", "calorie", "diet", "and", "were", "assigned", "randomly", "to", "daily", "consumption", "of", "a", "combination", "of", "inositol", "and", "alpha", "lipoic", "acid", "(", "77", "pts", ")", "or", "placebo", "(", "78", "pts", ")", "for", "six", "months", ".", "Primary", "outcomes", "we", "wanted", "to", "achieve", "were", "both", "reduction", "of", "more", "than", "20", "%", "of", "the", "HOMA", "-", "IR", "index", "and", "of", "triglycerides", "serum", "levels", ".", "Secondary", "outcomes", "expected", "were", "both", "the", "improvement", "of", "high", "-", "density", "lipoprotein", "cholesterol", "levels", "and", "the", "reduction", "of", "anthropometric", "features", "such", "as", "body", "mass", "index", "and", "waist", "-", "hip", "ratio", ".", "A", "significant", "HOMA", "-", "IR", "reduction", "of", "more", "than", "20", "%", "was", "evidenced", "in", "66.7", "%", "(", "P", "<", "0.0001", ")", "of", "patients", ",", "associated", "with", "a", "serum", "insulin", "level", "decrease", "in", "89.3", "%", "(", "P", "<", "0.0000", ")", ".", "A", "decrease", "in", "triglycerides", "was", "evidenced", "in", "43.2", "%", "of", "patients", "consuming", "the", "supplement", "(", "P", "<", "0.0001", ")", ".", "An", "increase", "in", "HDL", "cholesterol", "(", "48.6", "%", ")", "was", "found", "in", "the", "group", "consuming", "inositol", "with", "respect", "to", "the", "placebo", "group", ".", "A", "reduction", "in", "waist", "circumference", "and", "waist", "-", "hip", "ratio", "was", "found", "in", "the", "treated", "group", "with", "respect", "to", "the", "placebo", "group", ".", "Inositol", "combined", "with", "alpha", "lipoic", "acid", "can", "be", "used", "as", "a", "dietary", "supplement", "in", "insulin", "-", "resistant", "patients", "in", "order", "to", "increase", "their", "insulin", "sensitiveness", ".", "Daily", "consumption", "of", "inositol", "combined", "with", "alpha", "lipoic", "acid", "has", "a", "significant", "bearing", "on", "metabolic", "syndrome", ".", "As", "metabolic", "syndrome", "is", "considered", "a", "modifiable", "risk", "factor", "of", "breast", "tumorigenesis", ",", "further", "studies", "are", "required", "to", "assess", "whether", "inositol", "combined", "with", "alpha", "lipoic", "acid", "can", "be", "administered", "as", "a", "dietary", "supplement", "in", "breast", "cancer", "primary", "prevention", ".", "Current", "Controlled", "Trial", "ISRCTN", "74096908", "." ]

[ 0, 0, 17, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 19, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 0, 0, 23, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Predictors", "of", "follow", "-", "up", "exercise", "behavior", "6", "months", "after", "a", "randomized", "trial", "of", "exercise", "training", "during", "breast", "cancer", "chemotherapy", ".", "Exercise", "during", "breast", "cancer", "chemotherapy", "is", "beneficial", "but", "it", "needs", "to", "be", "maintained", "into", "survivorship", "to", "optimize", "long", "-", "term", "benefits", ".", "Here", ",", "we", "report", "the", "predictors", "of", "follow", "-", "up", "exercise", "behavior", "6", "months", "after", "a", "randomized", "exercise", "trial", "in", "breast", "cancer", "patients", ".", "Breast", "cancer", "patients", "(", "N", "=", "242", ")", "initiating", "adjuvant", "chemotherapy", "were", "randomly", "assigned", "to", "usual", "care", "(", "n", "=", "82", ")", ",", "supervised", "resistance", "exercise", "(", "n", "=", "82", ")", ",", "or", "supervised", "aerobic", "exercise", "(", "n", "=", "78", ")", "for", "the", "duration", "of", "their", "chemotherapy", ".", "At", "baseline", "and", "postintervention", ",", "data", "were", "collected", "on", "demographic", ",", "medical", ",", "behavioral", ",", "fitness", ",", "psychosocial", ",", "and", "motivational", "variables", ".", "At", "6", "-month", "follow", "-", "up", ",", "participants", "were", "mailed", "a", "questionnaire", "that", "assessed", "exercise", "behavior", "over", "the", "past", "6", "months", "and", "were", "categorized", "as", "either", "meeting", "both", "aerobic", "and", "resistance", "exercise", "guidelines", ",", "either", "exercise", "guideline", ",", "or", "neither", "exercise", "guideline", ".", "Two", "hundred", "one", "(", "83.1", "%", ")", "participants", "provided", "6", "-month", "follow", "-", "up", "data", "with", "85", "(", "42.3", "%", ")", "meeting", "neither", "exercise", "guideline", ",", "74", "(", "36.8", "%", ")", "meeting", "either", "exercise", "guideline", ",", "and", "42", "(", "20.9", "%", ")", "meeting", "both", "exercise", "guidelines", ".", "In", "multivariate", "regression", "analysis", ",", "seven", "variables", "independently", "predicted", "the", "likelihood", "of", "meeting", "exercise", "guidelines", "at", "follow", "-", "up", "including", "higher", "pretrial", "exercise", "(", "beta", "=", "0.23", ";", "P", "=", "0.002", ")", ",", "younger", "age", "(", "beta", "=", "-", "0.15", ";", "P", "=", "0.028", ")", ",", "breast", "conserving", "surgery", "(", "beta", "=", "0.15", ";", "P", "=", "0.033", ")", ",", "strength", "improvements", "(", "beta", "=", "0.15", ";", "P", "=", "0.028", ")", ",", "lower", "postintervention", "fatigue", "(", "beta", "=", "0.13", ";", "P", "=", "0.067", ")", ",", "a", "more", "positive", "attitude", "(", "beta", "=", "0.12", ";", "P", "=", "0.086", ")", ",", "and", "lower", "postintervention", "body", "mass", "index", "(", "beta", "=", "-", "0.11", ";", "P", "=", "0.105", ")", ".", "Exercise", "behavior", "6", "months", "after", "a", "randomized", "trial", "was", "predicted", "by", "a", "wide", "range", "of", "demographic", ",", "medical", ",", "behavioral", ",", "fitness", ",", "psychosocial", ",", "and", "motivational", "variables", ".", "These", "findings", "may", "help", "facilitate", "the", "uptake", "of", "exercise", "behavior", "during", "the", "transition", "from", "breast", "cancer", "patient", "to", "survivor", "." ]

[ 0, 0, 0, 0, 0, 17, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Preventing", "seroma", "formation", "after", "axillary", "dissection", "for", "breast", "cancer", ":", "a", "randomized", "clinical", "trial", ".", "Seroma", "formation", "after", "axillary", "dissection", "remains", "the", "most", "common", "early", "sequel", "to", "breast", "cancer", "surgery", ".", "Different", "surgical", "approaches", "have", "been", "performed", "to", "reduce", "seroma", "collection", ".", "Therefore", ",", "we", "aimed", "to", "assess", "the", "outcome", "of", "patients", "operated", "on", "using", "an", "ultrasound", "scalpel", "according", "to", "a", "standardized", "operative", "technique", "before", "accepting", "it", "as", "a", "routine", "procedure", ".", "A", "randomized", "controlled", "trial", "was", "designed", "to", "compare", "the", "outcome", "of", "patients", "undergoing", "breast", "surgery", "and", "axillary", "dissection", "using", "either", "standard", "scalpel", "blades", ",", "scissors", ",", "ligations", ",", "and", "electrocautery", "or", "the", "ultrasound", "scalpel", "only", ".", "Each", "arm", "of", "the", "trial", "consisted", "of", "30", "patients", ".", "A", "statistically", "significant", "benefit", "in", "terms", "of", "axillary", "and", "chest", "wall", "drainage", "volume", ",", "the", "number", "of", "axilla", "seromas", ",", "intraoperative", "bleeding", ",", "and", "hospitalization", "stay", "was", "recorded", "in", "the", "harmonic", "scalpel", "group", ".", "No", "significant", "differences", "were", "found", "between", "the", "2", "groups", "in", "terms", "of", "operative", "time", ".", "Finally", ",", "no", "postoperative", "hematoma", ",", "wound", "infections", ",", "and", "chest", "wall", "seroma", "were", "observed", ".", "The", "use", "of", "the", "harmonic", "scalpel", "was", "shown", "to", "reduce", "the", "magnitude", "of", "seromas", "in", "axilla", "and", "hospitalization", "stay", ".", "The", "harmonic", "scalpel", "can", "be", "used", "alone", "in", "axillary", "dissection", "with", "a", "safe", "and", "effective", "hemostasis", ".", "Our", "results", "must", "be", "confirmed", "by", "larger", "series", "." ]

[ 0, 13, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 17, 18, 18, 18, 18, 18, 18, 18, 18, 18, 0, 0, 19, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 21, 22, 22, 22, 0, 21, 22, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Dramatic", "dietary", "fat", "reduction", "is", "feasible", "for", "breast", "cancer", "patients", ":", "Results", "of", "the", "randomised", "study", ",", "WINS", "(", "UK", ")", "-", "stage", "1", ".", "The", "influence", "of", "dietary", "fat", "on", "breast", "tumour", "growth", "(", "1", ")", "and", ",", "more", "recently", ",", "on", "treatment", "outcomes", ",", "(", "2", ",", "3", ")", "suggests", "an", "important", "role", "for", "dietary", "advice", "in", "the", "future", "health", "of", "breast", "cancer", "patients", ".", "The", "Women", "'s", "Intervention", "Nutrition", "Study", "(", "UK", ")", "-", "Stage", "1", "assessed", "the", "feasibility", "of", "achieving", "and", "maintaining", "a", "≥", "50", "%", "reduction", "in", "reported", "fat", "intake", "in", "postmenopausal", ",", "early", "stage", "breast", "cancer", "patients", "in", "the", "UK", ".", "This", "study", "recruited", "patients", "in", "South", "-", "east", "England", "between", "2000", "and", "2005", ".", "They", "were", "randomly", "allocated", "into", "two", "groups", ".", "Group", "1", "(", "n", "=", "54", ")", ",", "received", "specific", "dietary", "counselling", "to", "halve", "their", "reported", "fat", "intake", "and", "maintain", "this", "low", "fat", "intake", ".", "Group", "2", "(", "n", "=", "53", ")", "received", "healthy", "eating", "advice", "only", ".", "Dietitian", "-", "led", "group", "sessions", "provided", "support", "for", "women", "in", "both", "groups", "over", "2", "years", ".", "(", "4", ")", "Validated", "four", "-", "day", "diaries", "were", "used", "to", "measure", "intake", ".", "Data", "analysis", "used", "Generalised", "Linear", "Model", "(", "GLM", ")", "for", "repeated", "measures", "and", "logistic", "regression", ".", "A", "significantly", "greater", "proportion", "of", "women", "in", "Group", "1", "reported", "a", "fat", "intake", "reduction", "of", "≥", "50", "%", "at", "3", "months", "(", "p", "<", ".", "001", ")", "and", "24", "months", "(", "p", "<", ".", "001", ")", "than", "in", "Group", "2", ".", "The", "size", "of", "the", "effect", "of", "active", "dietary", "counselling", "was", "37", "%", "at", "3", "months", "(", "95", "%", "CI", ":", "21", "-", "54", "%", ")", "and", "35", "%", "at", "24", "months", "(", "95", "%", "CI", ":", "17", "-", "53", "%", ")", ".", "Mean", "fat", "intake", "was", "halved", "at", "3", "months", "and", "24", "months", "in", "Group", "1", "only", ".", "Demonstrating", "such", "feasibility", "is", "a", "key", "step", "towards", "defining", "diet", "'s", "role", "in", "the", "secondary", "prevention", "of", "breast", "cancer", "." ]

[ 0, 17, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 15, 16, 16, 16, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 0, 0, 19, 20, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 0, 29, 30, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Exercise", "as", "a", "diagnostic", "and", "therapeutic", "tool", "for", "preventing", "cardiovascular", "morbidity", "in", "breast", "cancer", "patients-", "the", "BReast", "cancer", "EXercise", "InTervention", "(", "BREXIT", ")", "trial", "protocol", ".", "Anthracycline", "chemotherapy", "(", "AC", ")", "is", "an", "efficacious", "(", "neo", ")", "adjuvant", "treatment", "for", "early", "-", "stage", "breast", "cancer", "(", "BCa", ")", ",", "but", "is", "associated", "with", "an", "increased", "risk", "of", "cardiac", "dysfunction", "and", "functional", "disability", ".", "Observations", "suggest", "that", "regular", "exercise", "may", "be", "a", "useful", "therapy", "for", "the", "prevention", "of", "cardiovascular", "morbidity", "but", "it", "is", "yet", "to", "be", "interrogated", "in", "a", "large", "randomised", "trial", ".", "The", "primary", "aims", "of", "this", "study", "are", "to", ":", "1", ")", "determine", "if", "12", "-months", "of", "ET", "commenced", "at", "the", "onset", "of", "AC", "can", "reduce", "the", "proportion", "of", "BCa", "patients", "with", "functional", "disability", "(", "peak", "VO", "2", ",", "<", "18", "ml", "/", "kg", "/", "min", ")", ",", "and", "2", ")", "compare", "current", "standard", "-", "of", "-", "care", "for", "detecting", "cardiac", "dysfunction", "(", "resting", "left", "-", "ventricular", "ejection", "fraction", "assessed", "from", "3", "-dimensional", "echocardiography", ")", "to", "measures", "of", "cardiac", "reserve", "(", "peak", "exercise", "cardiac", "output", "assessed", "from", "exercise", "cardiac", "magnetic", "resonance", "imaging", ")", "for", "predicting", "the", "development", "of", "functional", "disability", "12", "-months", "following", "AC", ".", "Secondary", "aims", "are", "to", "assess", "the", "effects", "of", "ET", "on", "VO", "2", "peak", ",", "left", "ventricular", "morphology", ",", "vascular", "stiffness", ",", "cardiac", "biomarkers", ",", "body", "composition", ",", "bone", "mineral", "density", ",", "muscle", "strength", ",", "physical", "function", ",", "habitual", "physical", "activity", ",", "cognitive", "function", ",", "and", "multidimensional", "quality", "of", "life", ".", "One", "hundred", "women", "with", "early", "-", "stage", "BCa", "(", "40", "-", "75", "years", ")", "scheduled", "for", "AC", "will", "be", "randomized", "to", "12", "-months", "of", "structured", "exercise", "training", "(", "n", "=", "50", ")", "or", "a", "usual", "care", "control", "group", "(", "n", "=", "50", ")", ".", "Participants", "will", "be", "assessed", "at", "baseline", ",", "4", "-weeks", "following", "completion", "of", "AC", "(", "4", "-months", ")", "and", "at", "12", "-months", "for", "all", "measures", ".", "Women", "diagnosed", "with", "early", "-", "stage", "BCa", "have", "increased", "cardiac", "mortality", ".", "More", "sensitive", "strategies", "for", "diagnosing", "and", "preventing", "AC", "-", "induced", "cardiovascular", "impairment", "are", "critical", "for", "reducing", "cardiovascular", "morbidity", "and", "improving", "long", "-", "term", "health", "outcomes", "in", "BCa", "survivors", ".", "Australia", "&", "New", "Zealand", "Clinical", "Trials", "Registry", "(", "ANZCTR", ")", ",", "ID", ":", "12617001408370", ".", "Registered", "on", "5", "th", "of", "October", "2017", "." ]

[ 17, 0, 0, 0, 0, 0, 0, 0, 0, 13, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 4, 0, 0, 0, 19, 20, 20, 20, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Symptoms", "and", "QOL", "as", "Predictors", "of", "Chemoprevention", "Adherence", "in", "NRG", "Oncology", "/", "NSABP", "Trial", "P-", "1", ".", "Tamoxifen", "provides", "a", "50", "%", "reduction", "in", "the", "incidence", "of", "breast", "cancer", "(", "BC", ")", "among", "high", "-", "risk", "women", ",", "yet", "many", "do", "not", "adhere", "to", "the", "five", "-", "year", "course", "of", "therapy", ".", "Using", "the", "prospective", "double", "-", "blind", "National", "Surgical", "Adjuvant", "Breast", "and", "Bowel", "Project", "P-", "1", "study", ",", "we", "evaluated", "whether", "participant", "-", "reported", "outcomes", "were", "associated", "with", "drug", "adherence", "and", "whether", "baseline", "behavioral", "risk", "factors", "modified", "those", "associations", ".", "P-", "1", "participants", "were", "randomly", "assigned", "to", "placebo", "vs", "tamoxifen", "(", "20", "mg", "/", "day", ")", ".", "Mixed", "effects", "logistic", "regression", "was", "used", "to", "evaluate", "whether", "baseline", "or", "three", "-", "month", "SF-", "36", "quality", "of", "life", "(", "QOL", ")", "mental", "and", "physical", "component", "summaries", "(", "MCS", ",", "PCS", ")", ",", "and", "participant", "-", "reported", "symptoms", "(", "gynecologic", ",", "vasomotor", ",", "sexual", ",", "and", "other", ")", "predicted", "12", "-month", "drug", "adherence", "(", "76", "-", "100", "%", "of", "assigned", "medication", ")", ".", "The", "evaluation", "accounted", "for", "age", ",", "treatment", ",", "estimated", "breast", "cancer", "risk", ",", "education", ",", "baseline", "smoking", ",", "alcohol", "consumption", ",", "and", "obesity", ".", "All", "statistical", "tests", "were", "two", "-", "sided", ".", "Participants", "enrolled", "at", "least", "three", "years", "before", "trial", "unblinding", "and", "without", "medically", "indicated", "discontinuation", "before", "12", "months", "were", "eligible", "for", "the", "present", "analyses", "(", "n", "=", "10", "576", ")", ".", "At", "12", "months", ",", "84.3", "%", "were", "adherent", ".", "Statistically", "significant", "predictors", "of", "adherence", "were", ":", "three", "-", "month", "MCS", "(", "odds", "ratio", "[", "OR", "]", "=", "1.15", "per", "10", "points", ",", "95", "%", "confidence", "interval", "[", "CI", "]", "=", "1.06", "to", "1.25", ")", ";", "three", "-", "month", "gynecologic", "symptoms", "among", "moderate", "alcohol", "drinkers", "(", "OR", "=", ".", "79", ",", "95", "%", "CI", "=", "0.72", "to", "0.88", ")", ";", "baseline", "vasomotor", "symptoms", "among", "participants", "assigned", "tamoxifen", "(", "OR", "=", ".", "88", ",", "95", "%", "CI", "=", "0.80", "to", "0.97", ")", ";", "and", "three", "-", "month", "sexual", "symptoms", "among", "younger", "participants", "(", "OR", "=", ".", "89", "at", "age", "41", "years", ",", "95", "%", "CI", "=", "0.80", "to", "0.99", ")", ".", "The", "strongest", "association", "was", "with", "three", "-", "month", "other", "symptoms", "(", "OR", "=", ".", "77", ",", "95", "%", "CI", "=", "0.63", "to", "0.93", ")", ".", "PCS", "was", "not", "associated", "with", "adherence", ".", "Symptom", "and", "QOL", "associations", "were", "not", "modified", "by", "smoking", "or", "obesity", ".", "Promoting", "QOL", "and", "managing", "symptoms", "early", "in", "therapy", "may", "be", "important", "strategies", "to", "improve", "adherence", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 0, 17, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Efficacy", "and", "safety", "of", "palbociclib", "plus", "endocrine", "therapy", "in", "North", "American", "women", "with", "hormone", "receptor", "-", "positive", "/", "human", "epidermal", "growth", "factor", "receptor", "2", "-negative", "metastatic", "breast", "cancer", ".", "Palbociclib", "is", "a", "cyclin", "-", "dependent", "kinase", "4", "/", "6", "inhibitor", "indicated", "for", "treatment", "of", "hormone", "receptor", "-", "positive", "/", "human", "epidermal", "growth", "factor", "receptor", "2", "-negative", "advanced", "breast", "cancer", "in", "combination", "with", "endocrine", "therapy", ".", "We", "investigated", "the", "efficacy", "and", "safety", "of", "palbociclib", "in", "patients", "enrolled", "in", "North", "America", "during", "two", "-", "phase", "3", "trials", ":", "PALOMA-", "2", "(", "n", "=", "267", ",", "data", "cutoff", ":", "May", "31", ",", "2017", ")", "and", "PALOMA-", "3", "(", "n", "=", "240", ",", "data", "cutoffs", ":", "April", "13", ",", "2018", ",", "for", "overall", "survival", ",", "October", "23", ",", "2015", ",", "for", "all", "other", "outcomes", ")", ".", "In", "PALOMA-", "2", ",", "treatment", "-", "naïve", "postmenopausal", "patients", "with", "advanced", "breast", "cancer", "were", "randomized", "2", ":1", "to", "palbociclib", "(", "125", "mg", "/", "d", ";", "3", "weeks", "on", "/", "1", "week", "off", "[", "3", "/", "1", "]", ")", "plus", "letrozole", "(", "2.5", "mg", "/", "d", ",", "continuous", ")", "or", "placebo", "plus", "letrozole", ".", "In", "PALOMA-", "3", ",", "patients", "who", "progressed", "on", "prior", "endocrine", "therapy", "were", "randomized", "2", ":1", "to", "palbociclib", "(", "125", "mg", "/", "d", ";", "3", "/", "1", ")", "plus", "fulvestrant", "(", "500", "mg", ",", "per", "standard", "of", "care", ")", "or", "placebo", "plus", "fulvestrant", ";", "pre", "/", "perimenopausal", "patients", "received", "ovarian", "suppression", "with", "goserelin", ".", "Palbociclib", "plus", "endocrine", "therapy", "prolonged", "median", "progression", "-", "free", "survival", "vs", "placebo", "plus", "endocrine", "therapy", "in", "North", "American", "patients", "(", "PALOMA-", "2", ":", "25.4", "vs", "13.7", "months", ",", "hazard", "ratio", ",", "0.54", "[", "95", "%", "CI", ",", "0.40", "-", "0.74", "]", ",", "P", "<", ".", "0001", ";", "PALOMA-", "3", ":", "9.9", "vs", "3.5", "months", ",", "hazard", "ratio", ",", "0.52", "[", "95", "%", "CI", ",", "0.38", "-", "0.72", "]", ",", "P", "<", ".", "0001", ")", ".", "Objective", "response", "and", "clinical", "benefit", "response", "rates", "were", "greater", "with", "palbociclib", "vs", "placebo", "in", "North", "American", "patients", "in", "both", "trials", ".", "While", "overall", "survival", "data", "are", "not", "yet", "mature", "for", "PALOMA-", "2", ",", "median", "overall", "survival", "was", "increased", "in", "PALOMA-", "3", "(", "32.0", "vs", "24.7", "months", ",", "hazard", "ratio", ",", "0.75", "[", "95", "%", "CI", ",", "0.53", "-", "1.04", "]", ")", ",", "though", "this", "did", "not", "reach", "statistical", "significance", "(", "P", "=", ".", "0869", ")", ".", "Safety", "profiles", "in", "North", "American", "patients", "were", "similar", "to", "those", "of", "the", "overall", "populations", ";", "neutropenia", "was", "the", "most", "common", "treatment", "-", "emergent", "adverse", "event", ".", "No", "new", "safety", "signals", "were", "observed", ".", "In", "summary", ",", "palbociclib", "plus", "endocrine", "therapy", "is", "an", "effective", "treatment", "option", "for", "North", "American", "women", "with", "hormone", "receptor", "-", "positive", "/", "human", "epidermal", "growth", "factor", "receptor", "2", "-negative", "advanced", "breast", "cancer", "." ]

[ 0, 0, 0, 0, 17, 18, 18, 18, 0, 15, 16, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 20, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 37, 0, 39, 40, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 37, 0, 39, 40, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 37, 0, 39, 40, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Mitotic", "index", "and", "benefit", "of", "adjuvant", "anthracycline", "-", "based", "chemotherapy", "in", "patients", "with", "early", "breast", "cancer", ".", "We", "have", "evaluated", "whether", "the", "mitotic", "index", "could", "predict", "the", "benefit", "of", "adjuvant", "anthracycline", "-", "based", "chemotherapy", "in", "patients", "with", "early", "breast", "cancer", "who", "are", "eligible", "for", "adjuvant", "chemotherapy", "according", "to", "Saint", "Gallen", "guidelines", ".", "A", "total", "of", "937", "patients", "from", "a", "single", "institution", "were", "included", "in", "two", "randomized", "trials", "that", "compared", "adjuvant", "anthracycline", "-", "based", "chemotherapy", "with", "no", "chemotherapy", ".", "These", "patients", "account", "for", "83", "%", "of", "the", "overall", "population", "included", "in", "these", "trials", ".", "The", "first", "trial", "included", "premenopausal", "patients", "with", "node", "-", "negative", "disease", ",", "and", "the", "second", "one", "included", "postmenopausal", "patients", ",", "regardless", "of", "lymph", "node", "status", ".", "The", "treatment", "benefit", "was", "assessed", "according", "to", "the", "number", "of", "mitoses", "per", "field", "(", "x", "400", ")", ".", "The", "mitotic", "index", "was", "assessable", "in", "888", "patients", "(", "94", "%", ")", ".", "All", "the", "patients", "presented", "as", "either", "node", "-", "positive", "or", "an", "average", "-", "risk", "breast", "cancer", "according", "to", "2003", "Saint", "Gallen", "consensus", "conference", "guidelines", ".", "The", "5", "-year", "overall", "survival", "rates", "were", "91", "%", "and", "87", "%", "for", "patients", "treated", "or", "not", "with", "adjuvant", "chemotherapy", "(", "P", "=", ".", "09", ")", ".", "In", "patients", "with", "low", "/", "medium", "mitotic", "index", "(", "<", "three", "mitoses", "/", "field", ";", "n", "=", "450", ")", ",", "the", "5", "-year", "overall", "survival", "rate", "was", "95", "%", "for", "patients", "treated", "or", "not", "with", "adjuvant", "chemotherapy", "(", "P", "=", ".", "56", ")", ".", "In", "patients", "with", "high", "mitotic", "index", "(", ">", "/=", "three", "mitoses", "/", "field", ";", "n", "=", "438", ")", ",", "the", "5", "-year", "overall", "survival", "rates", "were", "86", "%", "and", "79", "%", "for", "patients", "treated", "or", "not", "treated", "with", "adjuvant", "chemotherapy", ",", "respectively", "(", "P", "=", ".", "02", ")", ".", "A", "high", "mitotic", "index", "is", "associated", "with", "the", "efficacy", "of", "adjuvant", "anthracycline", "-", "based", "chemotherapy", "in", "patients", "eligible", "for", "adjuvant", "chemotherapy", "in", "daily", "practice", "." ]

[ 0, 0, 0, 0, 0, 17, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Randomized", "phase", "II", ",", "double", "-", "blind", ",", "placebo", "-", "controlled", "study", "of", "exemestane", "with", "or", "without", "entinostat", "in", "postmenopausal", "women", "with", "locally", "recurrent", "or", "metastatic", "estrogen", "receptor", "-", "positive", "breast", "cancer", "progressing", "on", "treatment", "with", "a", "nonsteroidal", "aromatase", "inhibitor", ".", "Entinostat", "is", "an", "oral", "isoform", "selective", "histone", "deacetylase", "inhibitor", "that", "targets", "resistance", "to", "hormonal", "therapies", "in", "estrogen", "receptor", "-", "positive", "(", "ER+", ")", "breast", "cancer", ".", "This", "randomized", ",", "placebo", "-", "controlled", ",", "phase", "II", "study", "evaluated", "entinostat", "combined", "with", "the", "aromatase", "inhibitor", "exemestane", "versus", "exemestane", "alone", ".", "Postmenopausal", "women", "with", "ER+", "advanced", "breast", "cancer", "progressing", "on", "a", "nonsteroidal", "aromatase", "inhibitor", "were", "randomly", "assigned", "to", "exemestane", "25", "mg", "daily", "plus", "entinostat", "5", "mg", "once", "per", "week", "(", "EE", ")", "or", "exemestane", "plus", "placebo", "(", "EP", ")", ".", "The", "primary", "end", "point", "was", "progression", "-", "free", "survival", "(", "PFS", ")", ".", "Blood", "was", "collected", "in", "a", "subset", "of", "patients", "for", "evaluation", "of", "protein", "lysine", "acetylation", "as", "a", "biomarker", "of", "entinostat", "activity", ".", "One", "hundred", "thirty", "patients", "were", "randomly", "assigned", "(", "EE", "group", ",", "n", "=", "64", ";", "EP", "group", ",", "n", "=", "66", ")", ".", "Based", "on", "intent", "-", "to", "-", "treat", "analysis", ",", "treatment", "with", "EE", "improved", "median", "PFS", "to", "4.3", "months", "versus", "2.3", "months", "with", "EP", "(", "hazard", "ratio", "[", "HR", "]", ",", "0.73", ";", "95", "%", "CI", ",", "0.50", "to", "1.07", ";", "one", "-", "sided", "P", "=", ".", "055", ";", "two", "-", "sided", "P", "=", ".", "11", "[", "predefined", "significance", "level", "of", ".", "10", ",", "one", "-", "sided", "]", ")", ".", "Median", "overall", "survival", "was", "an", "exploratory", "end", "point", "and", "improved", "to", "28.1", "months", "with", "EE", "versus", "19.8", "months", "with", "EP", "(", "HR", ",", "0.59", ";", "95", "%", "CI", ",", "0.36", "to", "0.97", ";", "P", "=", ".", "036", ")", ".", "Fatigue", "and", "neutropenia", "were", "the", "most", "frequent", "grade", "3", "/", "4", "toxicities", ".", "Treatment", "discontinuation", "because", "of", "adverse", "events", "was", "higher", "in", "the", "EE", "group", "versus", "the", "EP", "group", "(", "11", "%", "v", "2", "%", ")", ".", "Protein", "lysine", "hyperacetylation", "in", "the", "EE", "biomarker", "subset", "was", "associated", "with", "prolonged", "PFS", ".", "Entinostat", "added", "to", "exemestane", "is", "generally", "well", "tolerated", "and", "demonstrated", "activity", "in", "patients", "with", "ER+", "advanced", "breast", "cancer", "in", "this", "signal", "-", "finding", "phase", "II", "study", ".", "Acetylation", "changes", "may", "provide", "an", "opportunity", "to", "maximize", "clinical", "benefit", "with", "entinostat", ".", "Plans", "for", "a", "confirmatory", "study", "are", "underway", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 20, 20, 20, 20, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 37, 38, 0, 39, 40, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 37, 38, 0, 0, 0, 39, 40, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 21, 22, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Relationship", "of", "ZNF", "423", "and", "CTSO", "with", "breast", "cancer", "risk", "in", "two", "randomised", "tamoxifen", "prevention", "trials", ".", "A", "case", "-", "control", "study", "from", "two", "randomised", "breast", "cancer", "prevention", "trials", "of", "tamoxifen", "and", "raloxifene", "(", "P-", "1", "and", "P-", "2", ")", "identified", "single", "-", "nucleotide", "polymorphisms", "(", "SNPs", ")", "in", "or", "near", "genes", "ZNF", "423", "and", "CTSO", "as", "factors", "which", "predict", "which", "women", "will", "derive", "most", "anti", "-", "cancer", "benefit", "from", "selective", "oestrogen", "receptor", "modulator", "(", "SERM", ")", "therapy", ".", "In", "this", "article", ",", "we", "further", "examine", "this", "question", "using", "blood", "samples", "from", "two", "randomised", "tamoxifen", "prevention", "trials", ":", "the", "International", "Breast", "Cancer", "Intervention", "Study", "I", "(", "IBIS", "-", "I", ")", "and", "the", "Royal", "Marsden", "trial", "(", "Marsden", ")", ".", "A", "nested", "case", "-", "control", "study", "was", "designed", "with", "2", ":1", "matching", "in", "IBIS", "-", "I", "and", "1", ":1", "matching", "in", "Marsden", ".", "The", "OncoArray", "was", "used", "for", "genotyping", "and", "included", "two", "SNPs", "previously", "identified", "(", "rs", "8060157", "in", "ZNF", "423", "and", "rs", "10030044", "near", "CTSO", ")", ",", "and", "102", "further", "SNPs", "within", "the", "same", "regions", ".", "Overall", ",", "there", "were", "369", "cases", "and", "662", "controls", ",", "with", "148", "cases", "and", "268", "controls", "from", "the", "tamoxifen", "arms", ".", "Odds", "ratios", "were", "estimated", "by", "conditional", "logistic", "regression", ",", "with", "Wald", "95", "%", "confidence", "intervals", ".", "In", "the", "tamoxifen", "arms", ",", "the", "per", "-", "allele", "odds", "ratio", "for", "rs", "8060157", "was", "0.99", "(", "95", "%", "CI", "0.73", "-", "1.34", ")", "and", "1.00", "(", "95", "%", "CI", "0.76", "-", "1.33", ")", "for", "rs", "10030044", ".", "In", "the", "placebo", "arm", ",", "the", "odds", "ratio", "was", "1.10", "(", "95", "%", "CI", "0.87", "-", "1.40", ")", "for", "rs", "8060157", "and", "1.01", "(", "95", "%", "CI", "0.79", "-", "1.29", ")", "for", "rs", "10030044", ".", "There", "was", "no", "evidence", "to", "suggest", "that", "other", "SNPs", "in", "the", "surrounding", "regions", "of", "these", "SNPs", "might", "predict", "response", "to", "tamoxifen", ".", "Results", "from", "these", "two", "prevention", "trials", "do", "not", "support", "the", "earlier", "findings", ".", "rs", "8060157", "in", "ZNF", "423", "and", "rs", "10030044", "near", "CTSO", "do", "not", "appear", "to", "predict", "response", "to", "tamoxifen", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 5, 19, 0, 0, 3, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Randomised", "phase", "II", "trial", "evaluating", "the", "safety", "of", "peripherally", "inserted", "catheters", "versus", "implanted", "port", "catheters", "during", "adjuvant", "chemotherapy", "in", "patients", "with", "early", "breast", "cancer", ".", "Both", "peripherally", "inserted", "central", "catheters", "(", "PICCs", ")", "and", "implanted", "port", "catheters", "(", "PORTs", ")", "are", "used", "for", "adjuvant", "chemotherapy", "(", "ACT", ")", "administration", "in", "patients", "with", "early", "breast", "cancer", "(", "EBC", ")", ".", "We", "aimed", "to", "compare", "the", "safety", "between", "PICCs", "and", "PORTs", "in", "this", "setting", ".", "This", "monocentric", "phase", "II", "randomised", "trial", "(", "NCT", "02095743", ")", "included", "patients", "with", "EBC", "who", "were", "eligible", "for", "ACT", ".", "Patients", "with", "curative", "anticoagulation", "therapy", "were", "excluded", ".", "The", "primary", "objective", "was", "to", "identify", "which", "device", "has", "a", "lower", "probability", "of", "catheter", "-", "related", "significant", "adverse", "events", "(", "CR", "-", "SAEs", ")", "within", "the", "35", "weeks", "after", "device", "implantation", ".", "The", "secondary", "objective", "was", "to", "evaluate", "quality", "of", "life", "(", "QoL", ")", "and", "patient", "satisfaction", ".", "From", "February", "2014", "to", "May", "2018", ",", "256", "patients", "were", "included", ",", "and", "253", "(", "99", "%", ")", "were", "analysed", ".", "Overall", ",", "31", "patients", "(", "12.2", "%", ")", "experienced", "CR", "-", "SAEs", ",", "which", "mainly", "included", "thromboembolic", "events", ".", "In", "an", "intention", "-", "to", "-", "treat", "analysis", ",", "the", "probability", "that", "a", "CR", "-", "SAE", "would", "occur", "was", "7.8", "%", "(", "10", "events", ")", "with", "PORTs", "versus", "16.6", "%", "(", "21", "events", ")", "with", "PICCs", "(", "hazard", "ratio", "[", "HR", "]", "=", "2.2", "[", "1.03", "-", "4.62", "]", ",", "P", "=", "0.036", ")", ".", "In", "a", "per", "-", "protocol", "analysis", ",", "PICCs", "were", "also", "associated", "with", "a", "higher", "risk", "of", "CR", "-", "SAEs", "than", "PORTs", "(", "HR", "=", "2.82", "[", "1.26", "-", "6.25", "]", ",", "P", "=", "0.007", ")", ".", "Regarding", "the", "secondary", "objectives", ",", "if", "there", "was", "no", "difference", "in", "QoL", "between", "the", "arms", ",", "then", "significantly", "more", "discomfort", "was", "reported", "among", "patients", "with", "PICCs", "than", "among", "patients", "with", "PORTs", "(", "P", "=", "0.002", "after", "implantation", "and", "P", "<", "0.001", "at", "mid", "-", "treatment", "or", "at", "the", "end", "of", "treatment", ")", ".", "CR", "-", "SAEs", "in", "patients", "with", "EBC", "are", "frequent", "but", "rarely", "impact", "the", "ACT", "process", ".", "Compared", "with", "PORTs", ",", "PICCs", "are", "associated", "with", "a", "significantly", "higher", "risk", "of", "CR", "-", "SAEs", "and", "more", "discomfort", ".", "PORTs", "should", "be", "preferred", "for", "ACT", "administration", "in", "patients", "with", "EBC", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 0, 19, 20, 20, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 0, 23, 24, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 0, 29, 30, 0, 25, 0, 0, 0, 0, 0, 31, 32, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Omega-", "3", "fatty", "acid", "use", "for", "obese", "breast", "cancer", "patients", "with", "aromatase", "inhibitor", "-", "related", "arthralgia", "(", "SWOG", "S", "0927", ")", ".", "Although", "aromatase", "inhibitors", "(", "AIs", ")", "prolong", "survival", "in", "post", "-", "menopausal", "breast", "cancer", "(", "BC", ")", "patients", ",", "AI", "-", "associated", "arthralgia", "can", "lead", "to", "discontinuation", ".", "Obese", "patients", "have", "higher", "rates", "of", "AI", "arthralgia", "than", "non", "-", "obese", "patients", ",", "but", "treatment", "options", "are", "limited", ".", "Omega-", "3", "fatty", "acid", "(", "O", "3", "-", "FA", ")", "treatment", "for", "AI", "arthralgia", "has", "produced", "mixed", "results", ".", "We", "performed", "an", "exploratory", "analysis", "of", "SWOG", "S", "0927", ",", "a", "multicenter", "randomized", "placebo", "-", "controlled", "trial", "of", "O", "3", "-", "FA", "use", "for", "AI", "arthralgia", ".", "Post", "-", "menopausal", "women", "with", "stage", "I", "-", "III", "BC", "taking", "an", "AI", "were", "randomized", "to", "24", "weeks", "of", "O", "3", "-", "FAs", "or", "placebo", ".", "Brief", "Pain", "Inventory", "(", "BPI", ")", "questionnaires", "and", "fasting", "serum", "were", "collected", "at", "baseline", ",", "12", ",", "and", "24", "weeks", ".", "The", "BPI", "assessment", "included", "worst", "pain", ",", "average", "pain", ",", "and", "pain", "interference", "scores", "(", "range", "0", "-", "10", ")", ".", "Among", "the", "249", "participants", ",", "139", "had", "BMI", "<", "30", "kg", "/", "m", "2", "(", "56", "%", ")", "and", "110", "had", "BMI", "≥", "30", "kg", "/", "m", "2", "(", "44", "%", ")", ".", "Among", "obese", "patients", ",", "O", "3", "-", "FA", "use", "was", "associated", "with", "significantly", "lower", "BPI", "worst", "pain", "scores", "at", "24", "weeks", "compared", "with", "placebo", "(", "4.36", "vs.", "5.70", ",", "p", "=", "0.02", ")", ",", "whereas", "among", "non", "-", "obese", "patients", ",", "there", "was", "no", "significant", "difference", "in", "scores", "between", "treatment", "arms", "(", "5.27", "vs.", "4.58", ",", "p", "=", "0.28", ";", "interaction", "p", "=", "0.05", ")", ".", "Similarly", ",", "O", "3", "-", "FA", "use", "was", "associated", "with", "lower", "BPI", "average", "pain", "and", "pain", "interference", "scores", "at", "24", "weeks", "compared", "with", "placebo", "among", "obese", "patients", ",", "but", "no", "significant", "difference", "between", "treatment", "arms", "in", "non", "-", "obese", "patients", "(", "interaction", "p", "=", "0.005", "and", "p", "=", "0.01", ",", "respectively", ")", ".", "In", "obese", "BC", "patients", ",", "O", "3", "-", "FA", "use", "was", "associated", "with", "significantly", "reduced", "AI", "arthralgia", "compared", "to", "placebo", "." ]

[ 17, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 13, 14, 14, 14, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 33, 0, 35, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 33, 0, 35, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Prevention", "of", "bone", "loss", "with", "risedronate", "in", "breast", "cancer", "survivors", ":", "a", "randomized", ",", "controlled", "clinical", "trial", ".", "In", "postmenopausal", "women", "with", "low", "bone", "mass", "and", "hormone", "-", "receptor", "-", "positive", "breast", "cancer", "on", "an", "aromatase", "inhibitor", ",", "risedronate", "maintained", "skeletal", "health", "assessed", "by", "bone", "density", "and", "turnover", "markers", ".", "Women", "with", "the", "greatest", "decreases", "in", "bone", "turnover", "markers", "at", "12", "months", "had", "the", "greatest", "increases", "in", "bone", "density", "at", "24", "months", ".", "Aromatase", "inhibitors", "(", "AIs", ")", ",", "adjuvant", "endocrine", "therapy", "for", "postmenopausal", "women", "with", "hormone", "-", "receptor", "-", "positive", "breast", "cancer", ",", "are", "associated", "with", "bone", "loss", "and", "fractures", ".", "Our", "objectives", "were", "to", "determine", "if", "(", "1", ")", "oral", "bisphosphonate", "therapy", "can", "prevent", "bone", "loss", "in", "women", "on", "an", "AI", "and", "(", "2", ")", "early", "changes", "in", "bone", "turnover", "markers", "(", "BTM", ")", "can", "predict", "later", "changes", "in", "bone", "mineral", "density", "(", "BMD", ")", ".", "We", "conducted", "a", "2", "-year", "double", "-", "blind", ",", "placebo", "-", "controlled", ",", "randomized", "trial", "in", "109", "postmenopausal", "women", "with", "low", "bone", "mass", "on", "an", "AI", "(", "anastrozole", ",", "letrozole", ",", "or", "exemestane", ")", "for", "hormone", "-", "receptor", "-", "positive", "breast", "cancer", ".", "Participants", "were", "randomized", "to", "once", "weekly", "risedronate", "35", "mg", "or", "placebo", ",", "and", "all", "received", "calcium", "plus", "vitamin", "D", ".", "The", "main", "outcome", "measures", "included", "BMD", ",", "BTM", "[", "carboxy", "-", "terminal", "collagen", "crosslinks", "(", "CTX", ")", "and", "N", "-", "terminal", "propeptide", "of", "type", "1", "procollagen", "(", "P", "1", "NP", ")", "]", ",", "and", "safety", ".", "Eighty", "-", "seven", "percent", "completed", "24", "months", ".", "BMD", "increased", "more", "in", "the", "active", "treatment", "group", "compared", "to", "placebo", "with", "an", "adjusted", "difference", "at", "24", "months", "of", "3.9", "±", "0.7", "percentage", "points", "at", "the", "spine", "and", "3.2", "±", "0.5", "percentage", "points", "at", "the", "hip", "(", "both", "p", "<", "0.05", ")", ".", "The", "adjusted", "difference", "between", "the", "active", "treatment", "and", "placebo", "groups", "were", "0.09", "±", "0.04", "nmol", "/", "LBCE", "for", "CTX", "and", "23.3", "±", "4.8", "μg", "/", "mL", "for", "P", "1", "NP", "(", "both", "p", "<", "0.05", ")", ".", "Women", "with", "greater", "12", "-month", "decreases", "in", "CTX", "and", "P", "1", "NP", "in", "the", "active", "treatment", "group", "had", "a", "greater", "24", "-month", "increase", "in", "spinal", "BMD", "(", "p", "<", "0.05", ")", ".", "The", "oral", "therapy", "was", "safe", "and", "well", "tolerated", ".", "In", "postmenopausal", "women", "with", "low", "bone", "mass", "and", "breast", "cancer", "on", "an", "AI", ",", "the", "oral", "bisphosphonate", "risedronate", "maintained", "skeletal", "health", "." ]

[ 0, 0, 13, 14, 0, 17, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 0, 23, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "prospective", "randomized", ",", "placebo", "-", "controlled", "skin", "care", "study", "in", "women", "diagnosed", "with", "breast", "cancer", "undergoing", "radiation", "therapy", ".", "To", "compare", "the", "effectiveness", "of", "three", "different", "skin", "care", "products", "versus", "a", "placebo", "in", "reducing", "the", "incidence", "of", "radiation", "therapy", "-", "induced", "skin", "reactions", "prophylactically", ".", "Prospective", "randomized", ",", "double", "-", "blinded", ",", "placebo", "-", "controlled", "study", ".", "A", "radiation", "oncology", "department", "at", "a", "National", "Cancer", "Institute", "-", "designated", "comprehensive", "cancer", "center", "in", "the", "southeastern", "United", "States", ".", "208", "women", "with", "breast", "cancer", "who", "were", "to", "receive", "whole", "breast", "radiation", "therapy", ".", "Patients", "were", "invited", "to", "participate", "after", "radiation", "therapy", "was", "documented", "as", "part", "of", "their", "treatment", "plan", ".", "Patients", "applied", "a", "skin", "care", "product", "starting", "on", "the", "first", "day", "of", "treatment", "and", "were", "assessed", "weekly", "by", "their", "radiation", "oncology", "nurse", ".", "Skin", "reaction", "score", "and", "skin", "product", ".", "None", "of", "the", "products", "were", "statistically", "better", "than", "placebo", "in", "preventing", "skin", "reactions", ".", "Increases", "in", "skin", "reaction", "over", "time", "did", "not", "vary", "with", "treatment", "group", "for", "the", "linear", "(", "p", "=", "0.16", ")", "and", "nonlinear", "(", "p", "=", "0.94", ")", "effects", "of", "time", "and", "for", "both", "time", "components", "tested", "together", "(", "p", "=", "0.41", ")", ".", "Ninety", "-", "five", "percent", "of", "women", "participating", "in", "this", "study", "experienced", "a", "radiation", "therapy", "-", "induced", "skin", "reaction", ".", "The", "development", "of", "guidelines", "to", "support", "safe", "patient", "care", "is", "encouraged", "because", "patients", "prefer", "to", "take", "action", "rather", "than", "do", "nothing", ".", "However", ",", "the", "findings", "do", "not", "demonstrate", "improved", "clinical", "outcomes", "with", "the", "use", "of", "skin", "care", "products", ".", "Healthcare", "providers", "should", "proactively", "educate", "patients", "about", "acute", "skin", "reactions", "and", "self", "-", "care", "strategies", "to", "minimize", "skin", "breakdown", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 0, 0, 19, 0, 0, 0, 0, 0, 13, 14, 14, 14, 14, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 16, 16, 0, 1, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "randomized", "trial", "of", "dietary", "intervention", "for", "breast", "cancer", "prevention", ".", "Epidemiologic", "data", "and", "animal", "experiments", "suggest", "that", "dietary", "fat", "may", "influence", "risk", "of", "breast", "cancer", ".", "To", "determine", "whether", "intervention", "with", "a", "low", "-", "fat", ",", "high", "-", "carbohydrate", "diet", "would", "reduce", "breast", "cancer", "incidence", "in", "women", "at", "increased", "risk", "of", "the", "disease", ",", "we", "carried", "out", "a", "randomized", "controlled", "trial", "in", "Canada", ".", "We", "recruited", "4", ",", "690", "women", "with", "extensive", "mammographic", "density", "and", "randomized", "them", "to", "an", "intervention", "group", "or", "a", "comparison", "group", ".", "The", "intervention", "group", "received", "intensive", "dietary", "counseling", "to", "reduce", "fat", "intake", "to", "a", "target", "of", "15", "%", "of", "calories", "and", "increase", "carbohydrate", "to", "65", "%", "of", "calories", ".", "Dietary", "intakes", "were", "assessed", "throughout", "using", "food", "records", ".", "Subjects", "were", "followed", "for", "at", "least", "7", "years", "and", "for", "an", "average", "of", "10", "years", ".", "The", "main", "outcome", "was", "invasive", "breast", "cancer", ".", "Percentage", "of", "calories", "from", "fat", "in", "the", "intervention", "group", "decreased", "from", "30", "%", "at", "baseline", "to", "20", "%", "after", "randomization", "and", "remained", "9", "%", "to", "10", "%", "lower", "than", "the", "comparison", "group", "throughout", ".", "There", "were", "118", "invasive", "breast", "cancers", "in", "the", "intervention", "group", "and", "102", "in", "the", "comparison", "group", "[", "adjusted", "hazard", "ratio", "=", "1.19", "(", "95", "%", "CI", ":", "0.91", "-", "1.55", ")", "]", ".", "Analysis", "of", "food", "records", "showed", "that", "fat", "intake", "at", "baseline", "and", "after", "randomization", "was", "not", "associated", "with", "total", "breast", "cancer", "incidence", ".", "Greater", "weight", "and", "lower", "carbohydrate", "intake", "at", "baseline", "and", "after", "randomization", "were", "associated", "with", "an", "increased", "risk", "of", "estrogen", "receptor", "(", "ER", ")", "-positive", "breast", "cancer", ".", "Our", "findings", "suggest", "that", "a", "sustained", "reduction", "in", "dietary", "fat", "intake", "did", "not", "reduce", "risk", "of", "breast", "cancer", "in", "women", "with", "extensive", "mammographic", "density", ".", "Weight", "and", "carbohydrate", "intakes", "were", "associated", "with", "risk", "of", "ER", "-", "positive", "breast", "cancer", "." ]

[ 0, 0, 0, 0, 17, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 0, 0, 0, 1, 2, 2, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 25, 21, 22, 22, 0, 0, 0, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 21, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Phase", "II", "study", "of", "metformin", "for", "reduction", "of", "obesity", "-", "associated", "breast", "cancer", "risk", ":", "a", "randomized", "controlled", "trial", "protocol", ".", "Two", "-", "thirds", "of", "U.S", ".", "adult", "women", "are", "overweight", "or", "obese", ".", "High", "body", "mass", "index", "(", "BMI", ")", "and", "adult", "weight", "gain", "are", "risk", "factors", "for", "a", "number", "of", "chronic", "diseases", ",", "including", "postmenopausal", "breast", "cancer", ".", "The", "higher", "postmenopausal", "breast", "cancer", "risk", "in", "women", "with", "elevated", "BMI", "is", "likely", "to", "be", "attributable", "to", "related", "metabolic", "disturbances", "including", "altered", "circulating", "sex", "steroid", "hormones", "and", "adipokines", ",", "elevated", "pro", "-", "inflammatory", "cytokines", ",", "and", "insulin", "resistance", ".", "Metformin", "is", "a", "widely", "used", "antidiabetic", "drug", "that", "has", "demonstrated", "favorable", "effects", "on", "metabolic", "disturbances", "and", "as", "such", "may", "lead", "to", "lower", "breast", "cancer", "risk", "in", "obese", "women", ".", "Further", ",", "the", "anti", "-", "proliferative", "effects", "of", "metformin", "suggest", "it", "may", "decrease", "breast", "density", ",", "an", "accepted", "biomarker", "of", "breast", "cancer", "risk", ".", "This", "is", "a", "Phase", "II", "randomized", ",", "double", "-", "blind", ",", "placebo", "-", "controlled", "trial", "of", "metformin", "in", "overweight", "/", "obese", "premenopausal", "women", "who", "have", "elements", "of", "metabolic", "syndrome", ".", "Eligible", "participants", "will", "be", "randomized", "to", "receive", "metformin", "850", "mg", "BID", "(", "n", "=", "75", ")", "or", "placebo", "(", "n", "=", "75", ")", "for", "12", "months", ".", "The", "primary", "endpoint", "is", "change", "in", "breast", "density", ",", "based", "on", "magnetic", "resonance", "imaging", "(", "MRI", ")", "acquired", "fat", "-", "water", "features", ".", "Secondary", "outcomes", "include", "changes", "in", "serum", "insulin", "levels", ",", "serum", "insulin", "-", "like", "growth", "factor", "(", "IGF", ")", "-", "1", "to", "insulin", "-", "like", "growth", "factor", "binding", "protein", "(", "IGFBP", ")", "-", "3", "ratio", ",", "serum", "IGF-", "2", "levels", ",", "serum", "testosterone", "levels", ",", "serum", "leptin", "to", "adiponectin", "ratio", ",", "body", "weight", ",", "and", "waist", "circumference", ".", "Exploratory", "outcomes", "include", "changes", "in", "metabolomic", "profiles", "in", "plasma", "and", "nipple", "aspirate", "fluid", ".", "Changes", "in", "tissue", "architecture", "as", "well", "as", "cellular", "and", "molecular", "targets", "in", "breast", "tissue", "collected", "in", "a", "subgroup", "of", "participants", "will", "also", "be", "explored", ".", "The", "study", "will", "evaluate", "whether", "metformin", "can", "result", "in", "favorable", "changes", "in", "breast", "density", ",", "select", "proteins", "and", "hormones", ",", "products", "of", "body", "metabolism", ",", "and", "body", "weight", "and", "composition", ".", "The", "study", "should", "help", "determine", "the", "potential", "breast", "cancer", "preventive", "activity", "of", "metformin", "in", "a", "growing", "population", "at", "risk", "for", "multiple", "diseases", ".", "ClinicalTrials.gov", "Identifier", ":", "NCT", "02028221", ".", "Registered", "on", "January", "2", ",", "2014", ".", "Grant", "#", ":", "1", "R", "01", "CA", "172444", "-", "01", "A", "1", "awarded", "on", "Sept", "11", ",", "2013", "." ]

[ 0, 0, 0, 0, 17, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 16, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 19, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 0, 23, 24, 24, 24, 0, 23, 24, 24, 0, 23, 24, 24, 24, 24, 0, 23, 24, 0, 0, 23, 24, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Randomized", "trial", "comparing", "axillary", "clearance", "versus", "no", "axillary", "clearance", "in", "older", "patients", "with", "breast", "cancer", ":", "first", "results", "of", "International", "Breast", "Cancer", "Study", "Group", "Trial", "10", "-", "93", ".", "Axillary", "clearance", "in", "early", "breast", "cancer", "aims", "to", "improve", "locoregional", "control", "and", "provide", "staging", "information", "but", "is", "associated", "with", "undesirable", "morbidity", ".", "We", "therefore", "investigated", "whether", "avoiding", "axillary", "surgery", "in", "older", "women", "would", "result", "in", "improved", "quality", "of", "life", "(", "QL", ")", "with", "similar", "disease", "-", "free", "survival", "(", "DFS", ")", "and", "overall", "survival", "(", "OS", ")", ".", "Between", "1993", "and", "2002", ",", "women", ">", "or", "=", "60", "years", "old", "with", "clinically", "node", "-", "negative", "operable", "breast", "cancer", "in", "whom", "adjuvant", "tamoxifen", "was", "considered", "indicated", "regardless", "of", "pathologic", "nodal", "status", "were", "randomly", "assigned", "to", "primary", "surgery", "plus", "axillary", "clearance", "(", "Sx", "+", "Ax", ")", "followed", "by", "tamoxifen", "(", "Tam", ")", "versus", "Sx", "without", "Ax", "followed", "by", "Tam", "for", "5", "consecutive", "years", ".", "The", "primary", "end", "point", "was", "QL", "reported", "by", "the", "patient", "and", "by", "physician", "assessment", ".", "A", "total", "of", "473", "patients", "(", "234", "to", "Sx", "+", "Ax", ",", "239", "to", "Sx", ")", "were", "randomly", "assigned", ".", "The", "median", "age", "was", "74", "years", ";", "80", "%", "had", "estrogen", "receptor", "-", "positive", "disease", ".", "In", "both", "the", "patients", "'", "subjective", "assessment", "of", "their", "QL", "and", "the", "physicians", "'", "perception", "of", "the", "patients", "'", "QL", ",", "the", "largest", "adverse", "QL", "effects", "of", "Ax", "were", "observed", "from", "baseline", "to", "the", "first", "postoperative", "assessment", ",", "but", "the", "differences", "tended", "to", "disappear", "in", "6", "to", "12", "months", ".", "At", "a", "median", "follow", "-", "up", "of", "6.6", "years", ",", "results", "for", "Sx", "+", "Ax", "and", "Sx", "yielded", "similar", "DFS", "(", "6", "-year", "DFS", ",", "67", "%", "v", "66", "%", ";", "hazard", "ratio", "[", "HR", "]", "Sx", "+", "Ax", "/", "Sx", ",", "1.06", ";", "95", "%", "CI", ",", "0.79", "to", "1.42", ";", "P", "=", ".", "69", ")", "and", "OS", "(", "6", "-year", "OS", ",", "75", "%", "v", "73", "%", ";", "HR", "Sx", "+", "Ax", "/", "Sx", ",", "1.05", ";", "95", "%", "CI", ",", "0.76", "to", "1.46", ";", "P", "=", ".", "77", ")", ".", "Avoiding", "axillary", "clearance", "for", "women", ">", "or", "=", "60", "years", "old", "who", "have", "clinically", "node", "-", "negative", "disease", "and", "receive", "Tam", "for", "endocrine", "-", "responsive", "disease", "yields", "similar", "efficacy", "with", "better", "early", "QL", "." ]

[ 0, 0, 0, 17, 18, 0, 19, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 3, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 21, 22, 22, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 21, 22, 22, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Healthy", "lifestyle", "and", "breast", "cancer", "risk", ":", "A", "case", "-", "control", "study", "in", "Morocco", ".", "Some", "modifiable", "risk", "factors", "have", "been", "independently", "associated", "with", "breast", "cancer", "(", "BC", ")", "risk", "in", "Moroccan", "women", ",", "but", "no", "studies", "have", "investigated", "their", "joint", "association", ".", "This", "study", "aimed", "to", "investigate", "the", "association", "between", "a", "Healthy", "Lifestyle", "Index", "(", "HLI", ")", "score", "and", "BC", "risk", "among", "Moroccan", "women", ".", "In", "this", "case", "-", "control", "study", ",", "300", "incident", "BC", "cases", "and", "300", "controls", ",", "matched", "by", "age", "and", "area", "of", "residence", "were", "recruited", ".", "Cases", "were", "women", "newly", "-", "diagnosed", "with", "histopathologically", "-", "confirmed", "BC", "at", "the", "University", "Hospital", "in", "Fez", ",", "Morocco", ".", "Controls", "were", "randomly", "selected", "healthy", "women", "recruited", "from", "6", "primary", "health", "centers", "in", "Fez", ".", "HLI", "scores", "developed", "within", "this", "study", "were", "assigned", "to", "participants", "based", "on", "11", "factors", "(", "red", "and", "processed", "meat", ",", "white", "meat", ",", "cream", ",", "cheese", ",", "fish", ",", "fruit", "and", "vegetables", ",", "physical", "activity", ",", "BMI", ",", "smoking", ",", "alcohol", "consumption", ",", "and", "breastfeeding", ")", ",", "where", "0", "was", "given", "to", "unhealthy", "and", "0.5", "or", "1", "to", "healthy", "levels", "of", "each", "factor", ".", "Conditional", "and", "unconditional", "logistic", "regression", "models", "were", "used", "to", "assess", "the", "association", "between", "HLI", "scores", "and", "BC", "risk", ".", "Mean", "of", "HLI", "scores", "were", "8.1", "(", "±", "1.1", ")", "and", "9.0", "(", "±", "0.9", ")", "in", "cases", "and", "controls", ",", "respectively", ",", "p", "<", "0.01", ".", "After", "adjusting", "for", "potential", "confounders", ",", "one", "-", "point", "increment", "in", "the", "HLI", "score", "was", "associated", "with", "56", "%", "(", "95", "%", "CI", ",", "CI", ":", "39", "-", "68", "%", ")", ",", "49", "%", "(", "95", "%", "CI", ":", "30", "-", "63", "%", ")", ",", "and", "59", "%", "(", "95", "%", "CI", ":", "40", "-", "72", "%", ")", "lower", "risks", "of", "BC", "in", "all", ",", "premenopausal", ",", "and", "postmenopausal", "women", ",", "respectively", ".", "High", "HLI", "scores", "were", "associated", "with", "decreased", "risk", "of", "BC", "in", "Moroccan", "women", ".", "These", "findings", "suggest", "that", "BC", "prevention", "policies", "should", "include", "strategies", "for", "engaging", "Moroccan", "women", "in", "healthy", "lifestyles", "." ]

[ 17, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 11, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 5, 19, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 15, 16, 16, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 33, 0, 41, 42, 0, 0, 35, 0, 0, 43, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Dose", "intensity", "in", "anthracycline", "-", "based", "chemotherapy", "for", "metastatic", "breast", "cancer", ":", "mature", "results", "of", "the", "randomised", "clinical", "trial", "ANZ", "9311", ".", "The", "separate", "impacts", "of", "dose", "and", "dose", "intensity", "of", "chemotherapy", "for", "metastatic", "breast", "cancer", "remain", "uncertain", ".", "The", "primary", "objective", "of", "this", "trial", "was", "to", "compare", "a", "short", ",", "high", "-", "dose", ",", "intensive", "course", "of", "epirubicin", "and", "cyclophosphamide", "(", "EC", ")", "with", "a", "longer", "conventional", "dose", "regimen", "delivering", "the", "same", "total", "dose", "of", "chemotherapy", ".", "This", "open", "label", "trial", "randomised", "235", "women", "with", "metastatic", "breast", "cancer", "to", "receive", "either", "high", "-", "dose", "epirubicin", "150", "mg", "/", "m", "2", "and", "cyclophosphamide", "1500", "mg", "/", "m", "2", "with", "filgrastim", "support", "every", "3", "weeks", "for", "3", "cycles", "(", "HDEC", ")", "or", "standard", "dose", "epirubicin", "75", "mg", "/", "m", "2", "and", "cyclophosphamide", "750", "mg", "/", "m", "2", "every", "3", "weeks", "for", "6", "cycles", "(", "SDEC", ")", ".", "Primary", "outcomes", "were", "time", "to", "progression", ",", "overall", "survival", "and", "quality", "of", "life", ".", "In", "118", "patients", "allocated", "HDEC", "90", "%", "of", "the", "planned", "dose", "was", "delivered", ",", "compared", "to", "96", "%", "in", "the", "117", "participants", "allocated", "SDEC", ".", "There", "were", "no", "significant", "differences", "in", "the", "time", "to", "disease", "progression", "(", "5.7", "vs.", "5.8", "months", ",", "P", "=", "0.19", ")", "or", "overall", "survival", "(", "14.5", "vs.", "16.5", "months", ",", "P", "=", "0.29", ")", "between", "HDEC", "and", "SDEC", ",", "respectively", ".", "Patients", "on", "HDEC", "reported", "worse", "quality", "of", "life", "during", "therapy", ",", "but", "scores", "improved", "after", "completion", "to", "approximate", "those", "reported", "by", "patients", "allocated", "SDEC", ".", "Objective", "tumour", "response", "was", "recorded", "in", "33", "(", "28", "%", ")", "on", "HDEC", "and", "42", "patients", "(", "36", "%", ")", "on", "SDEC", ".", "HDEC", "produced", "more", "haematologic", "toxicity", ".", "For", "women", "with", "metastatic", "breast", "cancer", ",", "disease", "progression", ",", "survival", "or", "quality", "of", "life", "were", "no", "better", "with", "high", "-", "dose", "intensity", "compared", "to", "standard", "dose", "EC", "chemotherapy", ".", "Australian", "Clinical", "Trials", "Registry", "registration", "number", "ACTRN", "12605000478617", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 9, 10, 10, 10, 10, 0, 0, 0, 17, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 0, 0, 0, 0, 0, 23, 24, 24, 0, 23, 24, 0, 23, 24, 24, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 37, 0, 39, 40, 0, 0, 0, 0, 0, 0, 21, 22, 0, 37, 0, 39, 40, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 25, 0, 29, 30, 0, 0, 0, 0, 27, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 21, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Avoiding", "axillary", "dissection", "in", "breast", "cancer", "surgery", ":", "a", "randomized", "trial", "to", "assess", "the", "role", "of", "axillary", "radiotherapy", ".", "The", "need", "to", "dissect", "axillary", "nodes", "in", "patients", "with", "early", "breast", "cancer", "and", "clinically", "negative", "axilla", "remains", "controversial", ".", "The", "aim", "of", "the", "study", "was", "to", "assess", "the", "role", "of", "axillary", "radiotherapy", "(", "RT", ")", "in", "reducing", "axillary", "metastases", "in", "patients", "with", "early", "breast", "cancer", "who", "did", "not", "receive", "axillary", "dissection", ".", "From", "1995", "to", "1998", ",", "435", "patients", "over", "45", "years", "old", "with", "breast", "cancer", "up", "to", "1.2", "cm", "and", "no", "palpable", "axillary", "nodes", "were", "randomized", "214", "to", "breast", "conservation", "without", "axillary", "treatment", "and", "221", "to", "breast", "conservation", "plus", "axillary", "RT", ".", "After", "a", "median", "follow", "-", "up", "of", "63", "months", ",", "overt", "axillary", "metastases", "were", "fewer", "than", "expected", ":", "three", "cases", "in", "the", "no", "axillary", "treatment", "group", "(", "1.5", "%", ")", "and", "one", "in", "the", "RT", "group", "(", "0.5", "%", ")", ".", "Expected", "cases", "were", "43", "in", "the", "no", "axillary", "treatment", "group", "and", "10", "in", "the", "RT", "group", ".", "Rates", "of", "distant", "metastases", "and", "local", "failures", "were", "low", ",", "and", "5", "-year", "disease", "free", "survival", "was", "96.0", "%", "(", "95", "%", "confidence", "interval", ",", "94.1", "%", "-", "97.9", "%", ")", "without", "significant", "differences", "between", "the", "two", "arms", ".", "This", "study", "suggests", "that", "occult", "axillary", "metastases", "might", "never", "become", "clinically", "overt", "and", "axillary", "dissection", "might", "be", "avoided", "in", "patients", "with", "small", "carcinomas", "and", "a", "clinically", "negative", "axilla", ".", "Axillary", "RT", "seems", "to", "protect", "the", "patients", "from", "axillary", "recurrence", "almost", "completely", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 1, 0, 7, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 19, 20, 20, 20, 20, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 31, 32, 0, 0, 25, 0, 0, 0, 0, 0, 29, 30, 0, 0, 21, 22, 0, 27, 0, 0, 0, 0, 0, 0, 0, 25, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 21, 22, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Effect", "of", "aerobic", "exercise", "intervention", "on", "markers", "of", "insulin", "resistance", "in", "breast", "cancer", "women", ".", "Insulin", "may", "affect", "breast", "cancer", "(", "BC", ")", "risk", "and", "prognosis", ".", "Exercise", "reduces", "insulin", "in", "obese", "BC", "survivors", ".", "We", "designed", "a", "randomised", "controlled", "trial", "to", "test", "the", "effect", "of", "an", "aerobic", "exercise", "intervention", "(", "AEI", ")", "on", "insulin", "parameters", "and", "body", "composition", "in", "non", "-", "obese", "BC", "women", "without", "insulin", "resistance", ".", "Thirty", "-", "eight", "BC", "women", "were", "randomised", "into", "an", "intervention", "group", "(", "IG", "=", "18", ")", "or", "control", "group", "(", "CG", "=", "20", ")", ".", "IG", "participated", "in", "a", "structured", "AEI", "for", "3", "months", ",", "while", "CG", "received", "only", "the", "Word", "Cancer", "Research", "Fund", "/", "American", "Institute", "Cancer", "Research", "(", "WCRF", "/", "AICR", ")", "recommendation", "to", "be", "physically", "active", ".", "Fasting", "insulin", ",", "homeostasis", "model", "assessment", "of", "insulin", "resistance", "(", "HOMA", "-", "IR", ")", "index", ",", "metabolic", "parameters", "and", "body", "composition", "were", "collected", "at", "baseline", "and", "after", "the", "AEI", ".", "IG", "reduced", "insulin", "and", "HOMA", "-", "IR", "index", "by", "15", "%", "and", "14", "%", ",", "while", "CG", "increased", "these", "parameters", "(", "+", "12", "%", "and", "+", "16", "%", ")", ".", "Insulin", "changed", "differently", "over", "time", "in", "the", "two", "randomised", "groups", "(", "pinteraction", "=", ".", "04", ")", ".", "The", "between", "-", "group", "differences", "in", "the", "change", "of", "insulin", "(", "IG", "=", "-", "1.2", "μU", "/", "ml", "versus", "CG", "=", "+", "0.8", "μU", "/", "ml", ")", "and", "HOMA", "-", "IR", "index", "(", "IG", "=", "-", "0.26", "versus", "CG", "=", "+", "0.25", ")", "were", "respectively", "significant", "(", "p", "=", ".", "04", ")", "and", "non", "-", "significant", "(", "p", "=", ".", "06", ")", ".", "IG", "significantly", "improved", "lower", "limb", "muscle", "mass", "in", "comparison", "with", "CG", "(", "p", "=", ".", "03", ")", ".", "A", "structured", "AEI", "may", "improve", "insulin", ",", "HOMA", "-", "IR", "index", "and", "body", "composition", "in", "non", "-", "obese", "BC", "survivors", "without", "insulin", "resistance", "." ]

[ 0, 0, 17, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 19, 20, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Effects", "of", "Intraoperative", "Low", "-", "Dose", "Ketamine", "on", "Persistent", "Postsurgical", "Pain", "after", "Breast", "Cancer", "Surgery", ":", "A", "Prospective", ",", "Randomized", ",", "Controlled", ",", "Double", "-", "Blind", "Study", ".", "Compared", "to", "acute", "postsurgical", "pain", ",", "studies", "regarding", "the", "role", "of", "ketamine", "in", "persistent", "postsurgical", "pain", "(", "PPSP", ")", "are", "limited", ".", "The", "aim", "of", "this", "clinical", "trial", "was", "to", "test", "if", "intraoperative", "low", "-", "dose", "ketamine", "without", "postoperative", "infusion", "would", "reduce", "PPSP", "development", "after", "breast", "cancer", "surgery", ".", "We", "used", "a", "randomized", ",", "double", "-", "blinded", ",", "placebo", "study", "design", ".", "This", "study", "was", "conducted", "at", "Pusan", "National", "University", "Hospital", ",", "Republic", "of", "Korea", ",", "between", "December", "2013", "and", "August", "2016", ".", "A", "total", "of", "184", "patients", "scheduled", "for", "breast", "cancer", "surgery", "were", "randomly", "assigned", "to", "either", "the", "control", "or", "ketamine", "group", ".", "Before", "skin", "incision", ",", "a", "bolus", "(", "0.5", "mg", "/", "kg", "of", "ketamine", "or", "placebo", ")", ",", "followed", "by", "a", "continuous", "infusion", "(", "0.12", "mg", "/", "kg", "/", "h", "of", "ketamine", "or", "placebo", ")", ",", "was", "administered", "until", "the", "end", "of", "the", "surgery", ".", "The", "patients", "were", "interviewed", "via", "telephone", "1", ",", "3", ",", "and", "6", "months", "after", "surgery", ".", "The", "first", "question", "was", "whether", "the", "patient", "had", "surgery", "-", "related", "pain", ".", "If", "answered", "affirmatively", ",", "questions", "from", "the", "Numeric", "Rating", "Scale", "for", "pain", "at", "rest", "(", "NRSr", ")", "and", "for", "coughing", "(", "NRSd", ")", "were", "also", "asked", ".", "Our", "primary", "outcome", "was", "the", "incidence", "of", "PPSP", "at", "3", "months", "after", "surgery", ".", "For", "PPSP", "analysis", ",", "168", "patients", "were", "included", ".", "The", "number", "of", "patients", "who", "experienced", "pain", "was", "significantly", "lower", "in", "the", "ketamine", "group", "at", "3", "months", "(", "86.9", "%", "in", "the", "control", "group", "vs", "69.0", "%", "in", "the", "ketamine", "group", ",", "P", "=", ".", "005", ")", "postoperatively", ".", "However", ",", "the", "NRSr", "and", "NRSd", "did", "not", "differ", "between", "the", "groups", "throughout", "the", "follow", "-", "up", ".", "There", "were", "no", "postoperative", "low", "-", "dose", "ketamine", "infusion", "groups", "to", "compare", "due", "to", "hospital", "regulations", ".", "Dosage", "of", "ketamine", "was", "too", "low", "to", "reduce", "the", "severity", "of", "PPSP", ".", "And", "by", "using", "propofol", "and", "remifentanil", "for", "anesthesia", ",", "different", "results", "can", "be", "deduced", "with", "volatile", "anesthetics", ".", "Data", "from", "written", "questionnaires", "would", "have", "been", "more", "specific", "than", "telephone", "interviews", "for", "long", "-", "term", "assessment", ".", "Though", "intraoperative", "low", "-", "dose", "ketamine", "without", "postoperative", "infusion", "significantly", "reduced", "the", "incidence", "of", "PPSP", "up", "to", "3", "months", "after", "breast", "cancer", "surgery", ",", "it", "failed", "to", "reduce", "clinically", "significant", "PPSP", "and", "improve", "patients", "'", "quality", "of", "life", ".", "Analgesia", ",", "breast", "cancer", ",", "chronic", "pain", ",", "ketamine", ",", "mastectomy", ",", "morphine", ",", "pain", ",", "postoperative", ",", "propofol", "." ]

[ 0, 0, 17, 18, 18, 18, 18, 0, 0, 13, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 16, 16, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 19, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 31, 32, 0, 0, 0, 0, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Do", "community", "-", "based", "patient", "assistance", "programs", "affect", "the", "treatment", "and", "well", "-", "being", "of", "patients", "with", "breast", "cancer", "?", "Patients", "with", "breast", "cancer", "who", "need", "adjuvant", "treatments", "often", "fail", "to", "receive", "them", ".", "High", "-", "quality", ",", "community", "-", "based", "patient", "-", "assistance", "programs", "are", "an", "underused", ",", "inexpensive", "resource", "to", "help", "patients", "with", "cancer", "obtain", "needed", "therapy", ".", "We", "sought", "to", "determine", "whether", "connecting", "women", "to", "patient", "-", "assistance", "programs", "would", "reduce", "underuse", "of", "adjuvant", "therapies", ".", "We", "conducted", "a", "randomized", "trial", "of", "374", "women", "(", "190", "assigned", "intervention", "[", "INT", "]", ",", "184", "to", "usual", "care", "[", "UC", "]", ")", "with", "early", "-", "stage", "breast", "cancer", "who", "underwent", "surgery", "between", "October", "2006", "and", "August", "2009", ".", "After", "initial", "needs", "assessment", ",", "individualized", "action", "plans", "were", "created", "to", "connect", "INT", "patients", "with", "targeted", "patient", "-", "assistance", "programs", ";", "UC", "patients", "received", "an", "informational", "pamphlet", ".", "Main", "outcome", "measures", "were", "receiving", "adjuvant", "treatment", "and", "obtaining", "help", ".", "High", "rates", "of", "INT", "and", "UC", "patients", "received", "treatment", ":", "87", "%", "INT", "versus", "91", "%", "UC", "women", "who", "underwent", "lumpectomy", "received", "radiotherapy", "(", "P", "=", ".", "39", ")", ";", "93", "%", "INT", "versus", "86", "%", "UC", "women", "with", "estrogen", "receptor", "(", "ER", ")", "-negative", "tumors", "≥", "1", "cm", "received", "chemotherapy", "(", "P", "=", ".", "42", ")", ";", "92", "%", "INT", "versus", "93", "%", "UC", "women", "with", "ER", "-", "positive", "tumors", "≥", "1", "cm", "received", "hormonal", "therapy", "(", "P", "=", ".", "80", ")", ".", "Many", "women", "reported", "needs", ":", "63", "%", "had", "informational", ";", "55", "%", ",", "psychosocial", ";", "and", "53", "%", ",", "practical", "needs", ".", "High", "rates", "of", "INT", "patients", "with", "needs", "connected", "with", "a", "program", "within", "2", "weeks", "(", "92", "%", ")", ".", "At", "6", "months", ",", "INT", "and", "UC", "women", "used", "patient", "-", "assistance", "programs", "at", "similar", "rates", "(", "75", "%", "v", "76", "%", ";", "P", "=", ".", "54", ")", ".", "Women", "with", "informational", "or", "psychosocial", "needs", "were", "more", "likely", "to", "receive", "help", "(", "relative", "risk", "[", "RR", "]", ",", "1.77", ";", "95", "%", "CI", ",", "1.51", "to", "1.90", "and", "RR", ",", "1.37", ";", "95", "%", "CI", ",", "1.06", "to", "1.61", ",", "respectively", ")", ".", "INT", "and", "UC", "patients", "received", "high", "rates", "of", "adjuvant", "treatment", "regardless", "of", "trial", "assignment", ".", "Patients", "with", "breast", "cancer", "who", "connect", "to", "relevant", "patient", "assistance", "programs", "receive", "useful", "informational", "and", "psychosocial", "but", "not", "practical", "help", "." ]

[ 0, 17, 18, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 3, 0, 0, 0, 0, 0, 0, 5, 0, 19, 20, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 0, 23, 24, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 29, 30, 0, 0, 31, 32, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Late", "toxicities", "and", "outcomes", "of", "adjuvant", "radiotherapy", "combined", "with", "concurrent", "bevacizumab", "in", "patients", "with", "triple", "-", "negative", "non", "-", "metastatic", "breast", "cancer", ".", "To", "evaluate", "the", "safety", "of", "the", "concurrent", "combination", "of", "bevacizumab", "with", "adjuvant", "radiotherapy", "(", "B", "-", "RT", ")", "in", "breast", "cancer", "(", "BC", ")", ".", "Multicentre", ",", "prospective", "study", ",", "of", "the", "toxicity", "of", "adjuvant", "radiotherapy", "(", "RT", ")", "alone", "or", "B", "-", "RT", "in", "patients", "with", "non", "-", "metastatic", "BC", "enrolled", "in", "randomized", "Phase", "3", "BEATRICE", "trial", ".", "Early", "and", "late", "toxicities", "were", "assessed", "by", "the", "Common", "Terminology", "Criteria", "for", "Adverse", "Events", "v.", "3.0", "during", "and", "12", "months", "after", "the", "completion", "of", "RT", ".", "From", "2007", "to", "2012", ",", "39", "females", "received", "adjuvant", "B", "-", "RT", "and", "45", "received", "adjuvant", "RT", "alone", ".", "Median", "follow", "-", "up", "was", "21.5", "months", ".", "All", "patients", "had", "triple", "-", "negative", "non", "-", "metastatic", "BC", "and", "received", "adjuvant", "chemotherapy", "followed", "by", "RT", ".", "90", "%", "of", "the", "39", "females", "treated", "by", "concurrent", "B", "-", "RT", "received", "whole", "breast", "irradiation", "(", "WBI", ")", "with", "a", "boost", "and", "4", "(", "10", "%", ")", "received", "post", "-", "mastectomy", "RT", ".", "Lymph", "node", "RT", "was", "delivered", "in", "49", "%", "of", "the", "females", "with", "internal", "mammary", "chain", "irradiation", ".", "The", "mean", "duration", "of", "bevacizumab", "was", "11.7", "months", ".", "38", "(", "84", "%", ")", "females", "treated", "by", "RT", "alone", "received", "WBI", "with", "a", "boost", "and", "16", "%", "of", "the", "females", "received", "post", "-", "mastectomy", "RT", ".", "Lymph", "node", "RT", "was", "delivered", "in", "47", "%", "of", "the", "females", "with", "internal", "mammary", "chain", "RT", "in", "31", "%", ".", "Grade", "3", "acute", "dermatitis", "was", "observed", "in", "9", "%", "of", "patients", "receiving", "B", "-", "RT", "and", "5", "%", "of", "patients", "receiving", "RT", "alone", "with", "no", "significant", "difference", ".", "1", "year", "after", "the", "completion", "of", "RT", ",", "the", "most", "common", "late", "grade", "1", "-", "2", "toxicities", "in", "the", "B", "-", "RT", "group", "were", "pain", "(", "18", "%", ")", ",", "fibrosis", "(", "8", "%", ")", "and", "telangiectasia", "(", "5", "%", ")", ".", "The", "concurrent", "bevacizumab", "with", "locoregional", "RT", "is", "associated", "with", "acceptable", "early", "and", "late", "1", "-year", "toxicities", "in", "patients", "with", "BC", ".", "The", "largest", "series", "of", "this", "association", "." ]

[ 0, 0, 0, 0, 0, 17, 18, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 5, 0, 19, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 29, 30, 0, 0, 21, 0, 29, 30, 30, 0, 21, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "[", "Efficacy", "of", "activated", "charcoal", "-", "epirubicin", "suspension", "for", "treatment", "of", "breast", "cancer", "with", "axillary", "metastasis", "]", ".", "To", "investigate", "the", "effect", "of", "activated", "charcoal", "-", "epirubicin", "suspension", "(", "Epi", "-", "CH", ")", "for", "treatment", "of", "breast", "cancer", "and", "clearance", "of", "axillary", "lymph", "node", "metastasis", ".", "Sixty", "patients", "with", "breast", "cancer", "of", "stages", "II", "-", "III", "were", "randomized", "into", "Epi", "-", "CH", "group", "(", "n=", "40", ")", "receiving", "injection", "with", "10", "mg", "Epi", "-", "CH", "in", "the", "tissue", "around", "the", "primary", "tumor", "72", "h", "before", "modified", "radical", "resection", "and", "control", "group", "(", "n=", "20", ")", "with", "10", "mg", "of", "aqueous", "epirubicin", "injection", "in", "the", "same", "region", ".", "The", "dissected", "axillary", "lymph", "nodes", "and", "the", "staining", "lymph", "nodes", "were", "counted", ".", "The", "concentration", "of", "epirubicin", "in", "the", "lymph", "nodes", "was", "detected", "by", "high", "-", "performance", "liquid", "chorography", ",", "and", "the", "specimens", "of", "lymph", "nodes", "were", "observed", "microscopically", ".", "In", "comparison", "with", "the", "control", "group", ",", "Epi", "-", "CH", "injection", "allowed", "dissection", "of", "4.04", "more", "lymph", "nodes", "(", "P", "<", "0.01", ")", "and", "resulted", "in", "the", "staining", "rate", "of", "the", "axillary", "lymph", "nodes", "of", "86.9", "%", "(", "565", "/", "650", ")", ".", "The", "proportion", "of", "the", "staining", "lymph", "nodes", "with", "diameter", ">", "1.0", "cm", "was", "significantly", "lower", "than", "that", "with", "diameter", "<", "or=", "1.0", "cm", "(", "96", "/", "131", "vs", "469", "/", "519", ",", "P", "<", "0.01", ")", ".", "The", "metastatic", "rate", "of", "stained", "lymph", "nodes", "was", "similar", "with", "that", "in", "non", "-", "stained", "lymph", "nodes", "(", "214", "/", "565", "vs", "23", "/", "85", ",", "P", ">", "0.05", ")", ".", "In", "Epi", "-", "CH", "group", ",", "the", "concentration", "of", "epirubicin", "in", "the", "stained", "lymph", "nodes", "was", "significantly", "higher", "than", "that", "in", "non", "-", "stained", "ones", "(", "443.0", "-", "/", "+", "123.1", "vs", "31.8", "-", "/", "+", "11.9", "ng", "/", "g", ",", "P", "<", "0.01", ")", ".", "Remarkable", "degeneration", "and", "necrosis", "could", "be", "observed", "microscopically", "in", "the", "stained", "lymph", "nodes", ".", "Epi", "-", "CH", "allows", "more", "effective", "treatment", "of", "breast", "cancer", "and", "clearance", "of", "axiliary", "metastasis", "by", "increasing", "the", "dissected", "lymph", "nodes", "and", "raising", "the", "concentration", "of", "epirubicin", "in", "the", "axillary", "lymph", "nodes", "." ]

[ 0, 0, 0, 17, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 29, 30, 0, 25, 0, 3, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 25, 0, 3, 0, 27, 0, 5, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 25, 0, 3, 0, 27, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 33, 0, 0, 0, 41, 0, 35, 0, 0, 0, 43, 44, 44, 44, 0, 0, 0, 0, 0, 0, 0, 21, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Phase", "II", "randomized", "study", "of", "whole", "-", "brain", "radiation", "therapy", "with", "or", "without", "concurrent", "temozolomide", "for", "brain", "metastases", "from", "breast", "cancer", ".", "To", "improve", "the", "therapeutic", "index", "of", "whole", "-", "brain", "radiation", "therapy", "(", "WBRT", ")", "in", "the", "treatment", "of", "brain", "metastases", "(", "BM", ")", "from", "breast", "cancer", ",", "we", "investigated", "the", "efficacy", "and", "safety", "of", "WBRT", "combined", "with", "temozolomide", "(", "TMZ", ")", "in", "this", "population", ".", "This", "phase", "II", "multicenter", "prospective", "randomized", "study", "included", "patients", "with", "newly", "diagnosed", "intraparenchymal", "BMs", "from", "breast", "cancer", ",", "unsuitable", "for", "surgery", "or", "radiosurgery", ".", "All", "patients", "received", "conformal", "WBRT", "(", "3", "Gy", "×", "10", "-", "30", "Gy", ")", ",", "with", "or", "without", "concomitant", "TMZ", "administered", "at", "a", "dosage", "of", "75", "mg", "/", "m", "(", "2", ")", "/", "day", "during", "the", "irradiation", "period", ".", "The", "primary", "end", "point", "was", "objective", "response", "rate", "(", "ORR", ")", "6", "weeks", "after", "the", "end", "of", "treatment", ",", "defined", "as", "a", "partial", "or", "complete", "response", "on", "systematic", "brain", "MRI", "(", "modified", "WHO", "criteria", ")", ".", "Secondary", "end", "points", "were", "progression", "-", "free", "survival", "(", "PFS", ")", "and", "overall", "survival", "(", "OS", ")", ",", "neurologic", "symptoms", ",", "and", "tolerability", ".", "Between", "February", "2008", "and", "November", "2010", ",", "100", "patients", "were", "enrolled", "in", "the", "study", "(", "50", "in", "the", "WBRT", "+", "TMZ", "arm", ",", "50", "in", "the", "WBRT", "arm", ")", ".", "Median", "age", "was", "55", "years", "(", "29", "-", "79", ")", ".", "Median", "follow", "-", "up", "was", "9.4", "months", "[", "1.0", "-", "68.1", "]", ".", "ORRs", "at", "6", "weeks", "were", "36", "%", "in", "the", "WBRT", "arm", "and", "30", "%", "in", "the", "WBRT", "+", "TMZ", "arm", "(", "NS", ")", ".", "In", "the", "WBRT", "arm", ",", "median", "PFS", "was", "7.4", "months", "and", "median", "OS", "was", "11.1", "months", ".", "In", "the", "WBRT", "+", "TMZ", "arm", ",", "median", "PFS", "was", "6.9", "months", "and", "median", "OS", "was", "9.4", "months", ".", "Treatment", "was", "well", "tolerated", "in", "this", "arm", ":", "the", "most", "common", "≥grade", "2", "acute", "toxicity", "was", "reversible", "lymphopenia", ".", "WBRT", "combined", "with", "TMZ", "did", "not", "significantly", "improve", "local", "control", "and", "survival", "in", "patients", "with", "BMs", "from", "breast", "cancer", ".", "CLINICALTRIALS.GOV", ":", "NCT", "00875355", "." ]

[ 0, 0, 0, 0, 0, 17, 18, 18, 18, 18, 18, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 0, 23, 24, 24, 24, 24, 0, 23, 24, 0, 0, 23, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 19, 0, 0, 0, 0, 0, 0, 7, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 21, 22, 22, 0, 31, 32, 0, 0, 0, 0, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 39, 40, 0, 21, 22, 0, 39, 40, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 37, 38, 0, 21, 22, 0, 37, 38, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "randomised", "study", "of", "tailored", "toxicity", "-", "based", "dosage", "of", "fluorouracil", "-", "epirubicin", "-", "cyclophosphamide", "chemotherapy", "for", "early", "breast", "cancer", "(", "SBG", "2000", "-", "1", ")", ".", "Retrospective", "studies", "have", "demonstrated", "a", "worse", "outcome", "in", "breast", "cancer", "patients", "not", "developing", "leukopenia", "during", "adjuvant", "chemotherapy", ".", "The", "SBG", "2000", "-", "1", "is", "the", "first", "randomised", "trial", "designed", "to", "compare", "individually", "dosed", "chemotherapy", "without", "G", "-", "CSF", "support", "based", "on", "grade", "of", "toxicity", "to", "standard", "-", "dosed", "chemotherapy", "based", "on", "body", "surface", "area", "(", "BSA", ")", ".", "Patients", "with", "early", "breast", "cancer", "were", "included", "and", "received", "the", "first", "cycle", "of", "standard", "FEC", "(", "fluorouracil", "600", "mg", "/", "m", "2", ",", "epirubicin", "60", "mg", "/", "m", "2", ",", "cyclophosphamide", "600", "mg", "/", "m", "2", ")", ".", "Patients", "with", "nadir", "leukopenia", "grade", "0", "-", "2", "after", "first", "cycle", "were", "randomised", "between", "either", "6", "additional", "courses", "of", "tailored", "FEC", "with", "increased", "doses", "(", "E", "75", "-", "90", "mg", "/", "m", "2", ",", "C", "900", "-", "1200", "mg", "/", "m", "2", ")", "or", "fixed", "treatment", "with", "6", "standard", "FEC", ".", "Patients", "with", "grade", "3", "-", "4", "leukopenia", "were", "registered", "and", "treated", "with", "6", "standard", "FEC", ".", "Primary", "end", "-", "point", "was", "distant", "disease", "-", "free", "survival", "(", "DDFS", ")", ".", "The", "study", "enrolled", "1535", "patients", ",", "of", "which", "1052", "patients", "were", "randomised", "to", "tailored", "FEC", "(", "N", "=", "524", ")", "or", "standard", "FEC", "(", "N", "=", "528", ")", ",", "whereas", "401", "patients", "with", "leukopenia", "grade", "3", "-", "4", "continued", "standard", "FEC", "and", "formed", "the", "registered", "cohort", ".", "Dose", "escalation", "did", "not", "statistically", "significantly", "improve", "10", "-year", "DDFS", "(", "79", "%", "and", "77", "%", ",", "HR", "0.87", ",", "CI", "0.67", "-", "1.14", ",", "P", "=", "0.32", ")", "or", "OS", "(", "82", "%", "and", "78", "%", ",", "respectively", ",", "HR", "0.89", ",", "CI", "0.57", "-", "1.16", ",", "P", "=", "0.38", ")", ".", "Corresponding", "estimates", "for", "the", "registered", "group", "of", "patients", "were", "DDFS", "79", "%", "and", "OS", "82", "%", ",", "respectively", ".", "The", "SBG", "2000", "-", "1", "study", "failed", "to", "show", "a", "statistically", "significant", "improvement", "of", "escalated", "and", "tailored", "-", "dosed", "chemotherapy", "compared", "with", "standard", "BSA", "-", "based", "chemotherapy", "in", "patients", "with", "low", "haematological", "toxicity", ",", "although", "all", "efficacy", "parameters", "showed", "a", "numerical", "advantage", "for", "tailored", "treatment", "." ]

[ 0, 0, 0, 0, 17, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 1, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 29, 30, 0, 21, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Effect", "of", "Education", "on", "Promoting", "Healthy", "Lifestyle", "Behaviors", "That", "Prevent", "Breast", "Cancer", "in", "Middle", "-", "Aged", "Women", ":", "Application", "of", "Protection", "Motivation", "Theory", ".", "In", "recent", "years", ",", "an", "increased", "incidence", "of", "breast", "cancer", "has", "made", "this", "disease", "the", "most", "common", "malignancy", "among", "Iranian", "women", ".", "Since", "education", "plays", "an", "important", "role", "in", "the", "implementation", "of", "preventive", "behaviors", "in", "breast", "cancer", "treatment", ",", "this", "study", "investigates", "the", "effect", "of", "educational", "interventions", "on", "the", "promotion", "of", "lifestyle", "-", "related", "behaviors", "that", "prevent", "breast", "cancer", "in", "middle", "-", "aged", "women", ".", "In", "this", "randomized", "control", "study", ",", "120", "women", "referred", "to", "Neyshabur", "Health", "Services", "Centers", "were", "randomly", "selected", "and", "divided", "into", "two", "groups", ":", "an", "intervention", "group", "(", "60", "subjects", ")", "and", "a", "control", "group", "(", "60", "subjects", ")", ".", "An", "educational", "intervention", "was", "carried", "out", "over", "five", "sessions", ",", "based", "on", "protective", "motivation", "theory", "constructs", ".", "Participants", "completed", "a", "researcher", "-", "designed", "questionnaire", "immediately", "and", "again", "2", "months", "after", "the", "intervention", ".", "The", "data", "were", "analyzed", "using", "IBM", "SPSS", "ver", ".", "19.0", "software", "(", "IBM", "Corp.", ",", "Armonk", ",", "NY", ",", "USA", ")", ".", "The", "results", "revealed", "a", "significant", "difference", "between", "the", "mean", "scores", "of", "participants", "exposed", "to", "protective", "motivation", "theory", ",", "awareness", ",", "and", "physical", "activities", "immediately", "and", "also", "2", "months", "after", "the", "intervention", "(", "P", "<", "0.05", ")", ".", "Although", "the", "healthy", "diet", "scores", "of", "the", "two", "groups", "differed", "significantly", "immediately", "after", "the", "educational", "intervention", "(", "P", "<", "0.05", ")", ",", "there", "was", "no", "significant", "difference", "between", "the", "groups", "2", "months", "after", "the", "intervention", "(", "P", "<", "0.05", ")", ".", "Given", "the", "effective", "role", "of", "education", "in", "protective", "motivation", "theory", "and", "the", "physical", "activity", "levels", "of", "the", "women", "who", "participated", "in", "this", "research", ",", "it", "seems", "clear", "that", "the", "women", "'s", "financial", "status", "shaped", "their", "ability", "to", "consume", "more", "fruits", "and", "vegetables", ".", "As", "this", "social", "element", "impacts", "the", "health", "of", "individuals", ",", "training", "programs", "alone", "can", "not", "succeed", "." ]

[ 0, 0, 17, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 11, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 19, 20, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "effect", "of", "reusable", "versus", "disposable", "draping", "material", "on", "infection", "rates", "in", "implant", "-", "based", "breast", "reconstruction", ":", "a", "prospective", "randomized", "trial", ".", "Clinical", "infection", "remains", "a", "significant", "problem", "in", "implant", "-", "based", "breast", "reconstruction", "and", "is", "a", "physical", "and", "emotional", "strain", "to", "the", "breast", "reconstruction", "patient", ".", "Bacterial", "strikethrough", "of", "draping", "and", "gown", "material", "is", "a", "likely", "source", "of", "infection", ".", "Strategies", "to", "reduce", "infection", "in", "implant", "-", "based", "breast", "reconstruction", "are", "essential", "to", "improve", "patient", "outcomes", ".", "The", "aim", "of", "this", "study", "is", "to", "determine", "if", "a", "disposable", "draping", "system", "is", "superior", "to", "reusable", "draping", "materials", "in", "the", "prevention", "of", "implant", "-", "based", "breast", "reconstruction", "infection", ".", "This", "single", "-", "institution", ",", "prospective", ",", "randomized", ",", "single", "-", "blinded", ",", "IRB", "-", "approved", "study", "enrolled", "women", "with", "breast", "cancer", "who", "were", "eligible", "for", "implant", "-", "based", "breast", "reconstruction", ".", "The", "primary", "endpoint", "was", "clinical", "infection", "by", "postoperative", "day", "30", ".", "Secondary", "endpoints", "included", "all", "other", "complications", "encountered", "throughout", "the", "follow", "-", "up", "period", "and", "culture", "data", ".", "Demographic", "data", "recorded", "included", "patient", "age", ",", "body", "mass", "index", ",", "diabetes", ",", "smoking", ",", "chemotherapy", ",", "radiation", ",", "and", "follow", "-", "up", ".", "Procedural", "data", "recorded", "included", "procedure", "type", ",", "procedure", "length", ",", "estimated", "blood", "loss", ",", "use", "of", "acellular", "dermal", "matrix", ",", "use", "of", "muscle", "flap", ",", "and", "inpatient", "versus", "outpatient", "setting", ".", "From", "March", "2010", "through", "January", "2012", ",", "107", "women", "were", "randomized", "and", "102", "completed", "the", "study", ".", "Five", "patients", "were", "determined", "not", "to", "be", "candidates", "for", "reconstruction", "after", "randomization", ".", "There", "were", "43", "patients", "in", "the", "Reusable", "Group", "and", "59", "patients", "in", "the", "Disposable", "Group", ".", "There", "were", "no", "significant", "differences", "in", "patient", "demographic", "data", ",", "procedural", "data", ",", "or", "the", "type", "of", "procedure", "performed", "between", "groups", ".", "In", "the", "Reusable", "Group", ",", "there", "were", "5", "infections", "(", "12", "%", ")", "within", "30", "days", "compared", "to", "0", "(", "0", "%", ")", "infections", "in", "the", "Disposable", "Group", "(", "P", "=", "0.012", ")", ".", "There", "was", "no", "significant", "difference", "in", "secondary", "complications", ".", "There", "was", "a", "trend", "for", "positive", "wound", "cultures", "(", "11", "%", "vs.", "3", "%", ",", "P", "=", "0.10", ")", "and", "positive", "drape", "cultures", "(", "17", "%", "vs.", "4", "%", ",", "P", "=", "0.08", ")", "in", "patients", "with", "clinical", "infection", ".", "There", "were", "no", "differences", "in", "the", "number", "of", "colony", "-", "forming", "units", "or", "positive", "cultures", "between", "groups", ".", "Disposable", "draping", "material", "is", "superior", "to", "a", "reusable", "draping", "system", "in", "the", "prevention", "of", "clinical", "infection", "within", "the", "immediate", "postoperative", "period", ".", "This", "study", "did", "not", "demonstrate", "a", "clear", "link", "between", "intraoperative", "culture", "data", "and", "the", "development", "of", "clinical", "infection", ".", "A", "completely", "disposable", "gown", "and", "draping", "system", "is", "recommended", "during", "implant", "-", "based", "breast", "reconstruction", "." ]

[ 0, 0, 0, 0, 0, 17, 18, 18, 0, 13, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 19, 20, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 27, 21, 0, 31, 32, 0, 0, 0, 0, 0, 0, 25, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Cryotherapy", "for", "the", "prevention", "of", "weekly", "paclitaxel", "-", "induced", "peripheral", "adverse", "events", "in", "breast", "cancer", "patients", ".", "This", "randomized", "phase", "II", "study", "was", "conducted", "to", "investigate", "the", "efficacy", "of", "cryotherapy", "in", "preventing", "peripheral", "neuropathy", "and", "dermatological", "adverse", "events", "in", "breast", "cancer", "patients", "treated", "with", "weekly", "paclitaxel", ".", "Patients", "treated", "with", "12", "weekly", "doses", "of", "paclitaxel", "for", "breast", "cancer", "were", "randomized", "(", "1", ":1", ")", "into", "a", "cryotherapy", "or", "control", "group", ".", "The", "primary", "endpoint", "was", "the", "percentage", "of", "patients", "with", "a", "marked", "decrease", "in", "the", "Functional", "Assessment", "of", "Cancer", "Therapy", "-", "Neurotoxicity", "(", "FACT", "-", "NTX", ")", "score", ".", "The", "secondary", "endpoints", "were", "Patient", "Neurotoxicity", "Questionnaire", "(", "PNQ", ")", ",", "Common", "Terminology", "Criteria", "for", "Adverse", "Event", "(", "CTCAE", ")", "for", "peripheral", "neuropathy", ",", "and", "FACT", "-", "Taxane", "score", ".", "Forty", "-", "four", "patients", "were", "randomly", "assigned", "to", "the", "cryotherapy", "(", "n", "=", "22", ")", "or", "control", "groups", "(", "n", "=", "22", ")", ".", "The", "percentage", "of", "patients", "with", "a", "marked", "decrease", "in", "FACT", "-", "NTX", "scores", "was", "significantly", "lower", "in", "the", "cryotherapy", "group", "than", "in", "the", "control", "group", "(", "41", "vs.", "73", "%", ",", "p", "=", "0.03", ")", ".", "The", "incidence", "of", "CTCAE", "grade", "≥", "2", "sensory", "(", "p", "=", "0.001", ")", "and", "motor", "peripheral", "neuropathy", "(", "p", "=", "0.01", ")", ",", "and", "PNQ", "grade", "D", "or", "higher", "for", "sensory", "peripheral", "neuropathy", "(", "p", "=", "0.02", ")", ",", "and", "decrease", "in", "the", "FACT", "-", "Taxane", "score", "(", "p", "=", "0.02", ")", "were", "also", "significantly", "lower", "in", "the", "cryotherapy", "group", "than", "in", "the", "control", "group", ".", "There", "were", "no", "serious", "side", "effects", "associated", "with", "cryotherapy", ".", "Cryotherapy", "is", "an", "effective", "approach", "for", "prevention", "of", "peripheral", "neuropathy", "and", "dermatological", "adverse", "events", "in", "breast", "cancer", "patients", "treated", "with", "weekly", "paclitaxel", "." ]

[ 17, 0, 0, 0, 0, 0, 0, 0, 0, 13, 14, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 13, 14, 0, 13, 14, 14, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Serum", "antioxidant", "capacity", ",", "biochemical", "profile", "and", "body", "composition", "of", "breast", "cancer", "survivors", "in", "a", "randomized", "Mediterranean", "dietary", "intervention", "study", ".", "Increasing", "evidence", "suggests", "that", "Mediterranean", "Diet", "(", "MD", ")", "is", "correlated", "with", "reduced", "risk", "of", "breast", "cancer", "(", "BC", ")", "and", "cancer", "mortality", ",", "since", "it", "modifies", "patients", "'", "serum", "antioxidant", "capacity", ",", "body", "composition", "and", "biochemical", "parameters", ".", "The", "aim", "of", "the", "study", "was", "to", "investigate", "whether", "a", "dietary", "intervention", "based", "on", "MD", "has", "a", "beneficial", "effect", "on", "these", "factors", ".", "In", "this", "intervention", "study", ",", "seventy", "female", "BC", "survivors", "were", "randomly", "assigned", "to", "(", "1", ")", "the", "intervention", "group", "(", "personalized", "dietary", "intervention", "based", "on", "MD", ")", "and", "(", "2", ")", "the", "control", "group", "(", "received", "the", "updated", "American", "Cancer", "Society", "Guidelines", "on", "Nutrition", "and", "Physical", "Activity", "for", "Cancer", "Prevention", "and", "ad", "libitum", "diet", ")", ".", "Both", "groups", "were", "assessed", "twice", "[", "beginning", ",", "end", "of", "study", "(", "after", "6", "months", ")", "]", "regarding", "their", "anthropometric", "and", "biochemical", "parameters", ",", "serum", "vitamin", "C", ",", "vitamin", "A", ",", "a", "-", "tocopherol", "and", "CoQ", "10", "levels", ",", "dietary", "intake", "and", "adherence", "to", "MD", ".", "An", "additional", "intermediate", "analysis", "was", "conducted", "on", "participants", "'", "body", "composition", "and", "biochemical", "profile", ".", "Concerning", "the", "intervention", "group", ",", "body", "weight", ",", "body", "fat", "mass", ",", "waist", "circumference", ",", "body", "mass", "index", "as", "well", "as", "HDL", "-", "cholesterol", "were", "significantly", "decreased", "(", "P", "<", "0.2", "%", ")", ".", "An", "increase", "was", "observed", "in", "the", "vitamin", "C", "levels", "in", "blood", "(", "P", "<", "0.2", "%", ")", ".", "In", "the", "control", "group", ",", "body", "weight", ",", "body", "fat", "mass", "and", "serum", "total", "cholesterol", "rose", "(", "P", "<", "0.2", "%", ")", ".", "At", "the", "end", "of", "the", "study", "the", "two", "groups", "were", "significantly", "different", "considering", "blood", "glucose", ",", "vitamin", "C", ",", "polyunsaturated", "fatty", "acids", ",", "vitamin", "A", "and", "a", "-", "tocopherol", "levels", ".", "This", "randomized", "dietary", "intervention", "based", "on", "MD", "managed", "to", "ameliorate", "serum", "antioxidant", "capacity", ",", "body", "composition", ",", "adherence", "to", "MD", "and", "glycemic", "profile", "of", "postmenopausal", "BC", "survivors", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 21, 22, 22, 0, 21, 22, 0, 21, 22, 22, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 21, 22, 22, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 21, 22, 0, 21, 22, 22, 0, 21, 22, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "efficacy", "and", "safety", "of", "neoadjuvant", "chemotherapy", "+", "/-", "letrozole", "in", "postmenopausal", "women", "with", "locally", "advanced", "breast", "cancer", ":", "a", "randomized", "phase", "III", "clinical", "trial", ".", "This", "two", "-", "arm", "randomized", "clinical", "study", "aimed", "to", "evaluate", "the", "efficacy", "and", "safety", "of", "neoadjuvant", "concurrent", "chemotherapy", "and", "letrozole", "in", "postmenopausal", "women", "with", "locally", "advanced", "breast", "carcinoma", ".", "One", "hundred", "and", "one", "postmenopausal", "women", "aged", "50", "-", "83", "years", "with", "pathologically", "proven", "locally", "advanced", "(", "clinical", "stage", "T", "3", ",", "T", "4", "and/or", "N", "2", ",", "N", "3", ")", "breast", "cancer", "were", "randomly", "assigned", "to", "receive", "neoadjuvant", "chemotherapy", "alone", "(", "control", "arm", ",", "n", "=", "51", ")", "or", "neoadjuvant", "chemotherapy", "concurrent", "with", "letrozole", "2.5", "mg", "(", "study", "arm", ",", "n", "=", "50", ")", ".", "Chemotherapy", "consisted", "of", "a", "median", "4", "(", "range", "3", "-", "5", ")", "cycles", "of", "intravenous", "5", "-fluorouracil", "600", "mg", "/", "m", "(", "2", ")", ",", "doxorubicin", "60", "mg", "/", "m", "(", "2", ")", ",", "and", "cyclophosphamide", "600", "mg", "/", "m", "(", "2", ")", ",", "every", "three", "weeks", ".", "All", "patients", "subsequently", "underwent", "modified", "radical", "mastectomy", "approximately", "two", "weeks", "after", "the", "last", "cycle", "of", "chemotherapy", ".", "Pathologic", "complete", "response", "rates", "were", "25.5", "%", "and", "10.2", "%", "in", "the", "study", "and", "the", "control", "group", ",", "respectively", "(", "P", "=", "0.049", ")", ".", "Similarly", ",", "clinical", "complete", "response", "rates", "were", "27.6", "%", "and", "10.2", "%", "in", "the", "study", "and", "the", "control", "group", ",", "respectively", "(", "P", "=", "0.037", ")", ".", "In", "the", "subgroup", "analysis", "of", "hormone", "receptor", "-", "positive", "cases", ",", "the", "complete", "response", "rates", "were", "more", "prominent", "in", "study", "group", "compared", "with", "control", "group", ".", "Common", "treatment", "-", "related", "side", "effects", "such", "as", "nausea", ",", "vomiting", ",", "bone", "marrow", "suppression", ",", "and", "mucositis", "were", "similar", "in", "both", "groups", ",", "but", "hot", "flush", "was", "more", "prevalent", "in", "study", "group", "compared", "with", "control", "group", "(", "P", "=", "0.023", ")", ".", "The", "addition", "of", "letrozole", "concurrently", "with", "neoadjuvant", "chemotherapy", "provides", "a", "higher", "clinical", "and", "pathologic", "response", "rates", "with", "acceptable", "toxicity", "compared", "with", "chemotherapy", "alone", "in", "postmenopausal", "women", "with", "locally", "advanced", "sensitive", "breast", "cancer", "." ]

[ 0, 0, 0, 0, 0, 17, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 7, 8, 8, 8, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 19, 20, 20, 20, 20, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 21, 0, 21, 22, 22, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "Randomized", "Trial", "Evaluating", "Bioimpedance", "Spectroscopy", "Versus", "Tape", "Measurement", "for", "the", "Prevention", "of", "Lymphedema", "Following", "Treatment", "for", "Breast", "Cancer", ":", "Interim", "Analysis", ".", "Breast", "cancer", "-", "related", "lymphedema", "(", "BCRL", ")", "represents", "a", "major", "source", "of", "morbidity", "among", "breast", "cancer", "survivors", ".", "Increasing", "data", "support", "early", "detection", "of", "subclinical", "BCRL", "followed", "by", "early", "intervention", ".", "A", "randomized", "controlled", "trial", "is", "being", "conducted", "comparing", "lymphedema", "progression", "rates", "using", "volume", "measurements", "calculated", "from", "the", "circumference", "using", "a", "tape", "measure", "(", "TM", ")", "or", "bioimpedance", "spectroscopy", "(", "BIS", ")", ".", "Patients", "were", "enrolled", "and", "randomized", "to", "either", "TM", "or", "BIS", "surveillance", ".", "Patients", "requiring", "early", "intervention", "were", "prescribed", "a", "compression", "sleeve", "and", "gauntlet", "for", "4", "weeks", "and", "then", "re", "-", "evaluated", ".", "The", "primary", "endpoint", "of", "the", "trial", "was", "the", "rate", "of", "progression", "to", "clinical", "lymphedema", "requiring", "complex", "decongestive", "physiotherapy", "(", "CDP", ")", ",", "with", "progression", "defined", "as", "a", "TM", "volume", "change", "in", "the", "at", "-", "risk", "arm", "≥", "10", "%", "above", "the", "presurgical", "baseline", ".", "This", "prespecified", "interim", "analysis", "was", "performed", "when", "at", "least", "500", "trial", "participants", "had", "≥", "12", "months", "of", "follow", "-", "up", ".", "A", "total", "of", "508", "patients", "were", "included", "in", "this", "analysis", ",", "with", "109", "(", "21.9", "%", ")", "patients", "triggering", "prethreshold", "interventions", ".", "Compared", "with", "TM", ",", "BIS", "had", "a", "lower", "rate", "of", "trigger", "(", "15.8", "%", "vs.", "28.5", "%", ",", "p", "<", "0.001", ")", "and", "longer", "times", "to", "trigger", "(", "9.5", "vs.", "2.8", "months", ",", "p", "=", "0.002", ")", ".", "Twelve", "triggering", "patients", "progressed", "to", "CDP", "(", "10", "in", "the", "TM", "group", "[", "14.7", "%", "]", "and", "2", "in", "the", "BIS", "group", "[", "4.9", "%", "]", ")", ",", "representing", "a", "67", "%", "relative", "reduction", "and", "a", "9.8", "%", "absolute", "reduction", "(", "p", "=", "0.130", ")", ".", "Interim", "results", "demonstrated", "that", "post", "-", "treatment", "surveillance", "with", "BIS", "reduced", "the", "absolute", "rates", "of", "progression", "of", "BCRL", "requiring", "CDP", "by", "approximately", "10", "%", ",", "a", "clinically", "meaningful", "improvement", ".", "These", "results", "support", "the", "concept", "of", "post", "-", "treatment", "surveillance", "with", "BIS", "to", "detect", "subclinical", "BCRL", "and", "initiate", "early", "intervention", "." ]

[ 0, 0, 0, 0, 17, 18, 0, 19, 20, 0, 0, 0, 0, 13, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 37, 0, 39, 40, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 27, 0, 0, 0, 0, 0, 31, 32, 0, 0, 25, 0, 0, 0, 0, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Randomized", "trial", "of", "a", "lay", "health", "advisor", "and", "computer", "intervention", "to", "increase", "mammography", "screening", "in", "African", "American", "women", ".", "Low", "-", "income", "African", "American", "women", "face", "numerous", "barriers", "to", "mammography", "screening", ".", "We", "tested", "the", "efficacy", "of", "a", "combined", "interactive", "computer", "program", "and", "lay", "health", "advisor", "intervention", "to", "increase", "mammography", "screening", ".", "In", "this", "randomized", ",", "single", "blind", "study", ",", "participants", "were", "181", "African", "American", "female", "health", "center", "patients", "of", "ages", "41", "to", "75", "years", ",", "at", "<", "or", "=", "250", "%", "of", "poverty", "level", ",", "with", "no", "breast", "cancer", "history", ",", "and", "with", "no", "screening", "mammogram", "in", "the", "past", "15", "months", ".", "They", "were", "assigned", "to", "either", "(", "a", ")", "a", "low", "-", "dose", "comparison", "group", "consisting", "of", "a", "culturally", "appropriate", "mammography", "screening", "pamphlet", "or", "(", "b", ")", "interactive", ",", "tailored", "computer", "instruction", "at", "baseline", "and", "four", "monthly", "lay", "health", "advisor", "counseling", "sessions", ".", "Self", "-", "reported", "screening", "data", "were", "collected", "at", "baseline", "and", "6", "months", "and", "verified", "by", "medical", "record", ".", "For", "intent", "-", "to", "-", "treat", "analysis", "of", "primary", "outcome", "(", "medical", "record", "-", "verified", "mammography", "screening", ",", "available", "on", "all", "but", "two", "participants", ")", ",", "the", "intervention", "group", "had", "increased", "screening", "to", "51", "%", "(", "45", "of", "89", ")", "compared", "with", "18", "%", "(", "16", "of", "90", ")", "for", "the", "comparison", "group", "at", "6", "months", ".", "When", "adjusted", "for", "employment", "status", ",", "disability", ",", "first", "-", "degree", "relatives", "with", "breast", "cancer", ",", "health", "insurance", ",", "and", "previous", "breast", "biopsies", ",", "the", "intervention", "group", "was", "three", "times", "more", "likely", "(", "adjusted", "relative", "risk", ",", "2.7", ";", "95", "%", "confidence", "interval", ",", "1.8", "-", "3.7", ";", "P", "<", "0.0001", ")", "to", "get", "screened", "than", "the", "low", "-", "dose", "comparison", "group", ".", "Similar", "results", "were", "found", "for", "self", "-", "reported", "mammography", "stage", "of", "screening", "adoption", ".", "The", "combined", "intervention", "was", "efficacious", "in", "improving", "mammography", "screening", "in", "low", "-", "income", "African", "American", "women", ",", "with", "an", "unadjusted", "effect", "size", "(", "relative", "risk", ",", "2.84", ")", "significantly", "higher", "(", "P", "<", "0.05", ")", "than", "that", "in", "previous", "studies", "of", "each", "intervention", "alone", "." ]

[ 0, 0, 0, 0, 17, 18, 18, 18, 18, 18, 0, 0, 0, 0, 0, 11, 12, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 29, 30, 0, 25, 0, 3, 0, 0, 0, 31, 32, 0, 27, 0, 5, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "randomized", "pilot", "trial", "of", "a", "couple", "-", "based", "intervention", "addressing", "sexual", "concerns", "for", "breast", "cancer", "survivors", ".", "The", "purpose", "was", "to", "test", "the", "feasibility", ",", "acceptability", ",", "and", "preliminary", "efficacy", "of", "a", "4", "-session", "couple", "-", "based", "Intimacy", "Enhancement", "(", "IE", ")", "intervention", "addressing", "breast", "cancer", "survivors", "'", "sexual", "concerns", "delivered", "via", "telephone", ".", "Twenty", "-", "nine", "post", "-", "treatment", "breast", "cancer", "survivors", "reporting", "sexual", "concerns", "and", "their", "intimate", "partners", "were", "randomized", "(", "2", ":1", ")", "to", "the", "IE", "intervention", "or", "to", "an", "educational", "control", "condition", ",", "both", "of", "which", "were", "delivered", "by", "trained", "psychosocial", "providers", ".", "Feasibility", "and", "acceptability", "were", "measured", "through", "recruitment", ",", "retention", ",", "session", "completion", ",", "and", "post", "-", "intervention", "program", "evaluations", ".", "Couples", "completed", "validated", "sexual", ",", "relationship", ",", "and", "psychosocial", "outcome", "measures", "at", "pre-", "and", "post", "-", "intervention", ".", "Between", "-", "group", "effect", "sizes", "and", "95", "%", "confidence", "intervals", "were", "calculated", "using", "the", "Hedges", "g.", "Data", "supported", "intervention", "feasibility", "and", "acceptability", ".", "For", "survivors", ",", "the", "IE", "intervention", "had", "medium", "to", "large", "positive", "effects", "on", "all", "sexual", "outcomes", "and", "most", "psychosocial", "outcomes", ".", "Effects", "were", "less", "visible", "for", "relationship", "outcomes", "and", "were", "similar", "but", "somewhat", "smaller", "for", "partners", ".", "The", "IE", "intervention", "demonstrated", "feasibility", ",", "acceptability", ",", "and", "promise", "in", "addressing", "breast", "cancer", "survivors", "'", "sexual", "concerns", "and", "enhancing", "their", "and", "their", "partners", "'", "intimate", "relationships", "and", "psychosocial", "well", "-", "being", ".", "Implications", "for", "Psychosocial", "Oncology", "Practice", "The", "IE", "intervention", "demonstrated", "feasibility", "and", "acceptability", ",", "suggesting", "it", "could", "be", "well", "-", "received", "by", "breast", "cancer", "survivors", "with", "sexual", "concerns", "and", "their", "partners", ".", "Effects", "of", "the", "IE", "intervention", "on", "breast", "cancer", "survivors", "'", "sexual", "concerns", "and", "on", "their", "and", "their", "partners", "'", "intimate", "relationships", "and", "psychosocial", "well", "-", "being", "could", "not", "be", "attributed", "to", "therapist", "time", "and", "attention", ".", "Interventions", "that", "psychosocial", "providers", "can", "use", "to", "address", "breast", "cancer", "survivors", "'", "sexual", "concerns", "are", "important", "to", "the", "growing", "number", "of", "breast", "cancer", "survivors", "living", "for", "many", "years", "after", "their", "diagnosis", "." ]

[ 0, 0, 0, 0, 0, 0, 17, 18, 18, 18, 0, 13, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Postoperative", "adjuvant", "use", "of", "carmofur", "for", "early", "breast", "cancer", ".", "The", "efficacy", "of", "oral", "fluoropyrimidine", "carmofur", "was", "evaluated", "for", "adjuvant", "use", "for", "breast", "cancer", ".", "150", "patients", "with", "breast", "cancer", "of", "T", "0", "N", "1", ",", "T", "1", ",", "N", "1", ",", "T", "2", "N", "0", ",", "and", "T", "2", "N", "1", "were", "randomized", "to", "100", "for", "carmofur", "and", "50", "for", "carboquone", ".", "Both", "drugs", "were", "administered", "continuously", "for", "28", "days", "cyclically", "for", "5", "years", "with", "a", "cessation", "period", "of", "28", "days", "for", "carmofur", "and", "56", "days", "for", "carboquone", ".", "Overall", "survival", "excluding", "non", "-", "breast", "cancer", "death", "was", "90", "%", "for", "the", "carmofur", "group", "and", "88", "%", "for", "the", "carboquone", "group", ",", "adjusted", "by", "Cox", "'s", "regression", "analysis", ".", "Difference", "in", "drug", "never", "affected", "survival", ".", "Leukocyte", "count", "was", "decreased", "in", "the", "carboquone", "group", ",", "but", "no", "change", "in", "serum", "transaminase", "was", "found", "in", "either", "group", ".", "Ten", "patients", ",", "5", "for", "carmofur", "and", "5", "for", "carboquone", ",", "suffered", "from", "second", "malignancy", ",", "more", "than", "expected", "in", "the", "normal", "population", ",", "but", "difference", "in", "the", "cumulative", "rate", "of", "each", "group", "was", "not", "significant", ".", "Adjuvant", "use", "of", "carmofur", "as", "well", "as", "carboquone", "is", "beneficial", "for", "early", "breast", "cancer", "." ]

[ 0, 0, 0, 0, 17, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 3, 0, 0, 0, 5, 0, 19, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 0, 0, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 25, 0, 0, 0, 27, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Comparative", "efficacy", "of", "palbociclib", ",", "ribociclib", "and", "abemaciclib", "for", "ER+", "metastatic", "breast", "cancer", ":", "an", "adjusted", "indirect", "analysis", "of", "randomized", "controlled", "trials", ".", "Several", "trials", "have", "demonstrated", "the", "benefit", "of", "anti", "-", "CDK", "4", "/", "6", "inhibitors", "plus", "endocrine", "therapy", "in", "estrogen", "receptor", "-", "positive", "(", "ER+", ")", "advanced", "breast", "cancer", "(", "BC", ")", ",", "in", "first", "or", "subsequent", "lines", "of", "therapy", ".", "However", ",", "due", "to", "the", "lack", "of", "direct", "/", "indirect", "comparisons", ",", "there", "are", "no", "data", "demonstrating", "the", "superiority", "of", "one", "drug", "over", "the", "other", ".", "We", "compared", "the", "effectiveness", "of", "palbociclib", ",", "ribociclib", ",", "and", "abemaciclib", "in", "advanced", "ER", "+", "BC", "via", "an", "indirect", "adjusted", "analysis", ".", "We", "performed", "electronic", "searches", "in", "the", "PubMed", ",", "EMBASE", ",", "and", "Cochrane", "databases", "for", "prospective", "phase", "3", "randomized", "trials", "evaluating", "anti", "-", "CDK", "4", "/", "6", "inhibitors", "plus", "endocrine", "agents", ".", "We", "compared", "the", "results", "with", "an", "adjusted", "indirect", "analysis", "of", "randomized", "-", "controlled", "trials", ".", "Outcomes", "of", "interest", "were", "progression", "-", "free", "survival", "(", "PFS", ")", ",", "overall", "response", "rate", "(", "ORR", ")", "and", "G", "3", "-", "4", "toxicities", "occurring", "in", "≥", "5", "%", "of", "patients", ".", "Six", "trials", "and", "six", "treatment", "arms", "including", "a", "total", "of", "3743", "participants", ",", "were", "included", ".", "For", "PFS", "and", "ORR", "analysis", ",", "the", "three", "agents", "were", "similar", "in", "both", "first-", "and", "second", "-", "line", "studies", ".", "All", "G", "3", "-", "4", "toxicities", "were", "similar", ",", "with", "reduced", "risk", "of", "diarrhea", "for", "palbociclib", "versus", "abemaciclib", "(", "relative", "risk", "[", "RR", "]", "0.13", ",", "95", "%", "CI", "0.02", "-", "0.92", ";", "P", "=", "0.04", ")", "and", "of", "QTc", "prolongation", "for", "palbociclib", "versus", "ribociclib", "(", "RR", "0.02", ",", "95", "%", "CI", "0", "-", "0.83", ";", "P", "=", "0.03", ")", ".", "Despite", "different", "inclusion", "criteria", "and", "length", "of", "follow", "-", "up", ",", "similar", "features", "were", "noticed", "among", "second", "-", "line", "studies", "with", "the", "exception", "of", "increased", "risk", "of", "anemia", "G", "3", "-", "4", "and", "diarrhea", "G", "3", "-", "4", "for", "abemaciclib", ".", "Based", "on", "PFS", "and", "ORR", "results", "of", "this", "indirect", "meta", "-", "analysis", ",", "palbociclib", ",", "ribociclib", ",", "and", "abemaciclib", "are", "equally", "effective", "in", "either", "first-", "or", "second", "-", "line", "therapy", "for", "advanced", "ER", "+", "BC", ".", "They", ",", "however", ",", "ported", "different", "toxicity", "profiles", "." ]

[ 0, 0, 0, 17, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 0, 23, 24, 24, 24, 24, 24, 0, 23, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 21, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Cardioprotective", "effect", "of", "Platycodon", "grandiflorum", "in", "patients", "with", "early", "breast", "cancer", "receiving", "anthracycline", "-", "based", "chemotherapy", ":", "study", "protocol", "for", "a", "randomized", "controlled", "trial", ".", "Anthracyclines", ",", "alone", "or", "in", "combination", "with", "other", "drugs", ",", "are", "among", "the", "most", "effective", "chemotherapeutic", "agents", "to", "treat", "breast", "cancer", "both", "in", "the", "adjuvant", "and", "neoadjuvant", "setting", ".", "Unfortunately", ",", "anthracycline", "-", "associated", "dose", "-", "dependent", "cardiotoxicity", "is", "a", "limiting", "factor", "in", "clinical", "use", ".", "Extensive", "efforts", "have", "been", "devoted", "to", "identifying", "strategies", "to", "prevent", "anthracycline", "-", "induced", "cardiotoxicity", ".", "However", ",", "most", "cardioprotective", "agents", "have", "shown", "little", "effect", "in", "clinical", "trials", ".", "Herbal", "medicines", "are", "pure", ",", "natural", "substances", "that", "have", "been", "used", "for", "centuries", "in", "many", "countries", ",", "including", "China", ".", "This", "trial", "aims", "to", "evaluate", "the", "cardioprotective", "effects", "and", "safety", "of", "Platycodon", "grandiflorum", "granules", "compared", "to", "placebo", "granules", "in", "patients", "with", "early", "breast", "cancer", "receiving", "anthracycline", "-", "based", "chemotherapy", ".", "This", "study", "is", "a", "single", "-", "center", ",", "double", "-", "blinded", ",", "randomized", ",", "placebo", "-", "controlled", ",", "parallel", "-", "group", "trial", ".", "A", "total", "of", "120", "patients", "will", "be", "randomly", "allocated", "in", "a", "1", ":1", "ratio", "to", "receive", "either", "P", ".", "grandiflorum", "granules", "or", "placebo", "granules", "twice", "daily", "for", "12", "weeks", ".", "The", "primary", "outcome", "is", "heart", "failure", "(", "either", "clinical", "or", "subclinical", ")", ".", "The", "secondary", "outcomes", "include", "all", "-", "cause", "mortality", ",", "cardiac", "death", ",", "electrocardiogram", "(", "ECG", ")", "findings", ",", "left", "ventricular", "diastolic", "function", ",", "longitudinal", "systolic", "strain", "and", "velocities", "measured", "by", "tissue", "Doppler", "imaging", ",", "cardiac", "biomarkers", ",", "such", "as", "troponin", "I", "(", "TnI", ")", ",", "brain", "natriuretic", "peptide", "(", "BNP", ")", ",", "and", "creatine", "kinase", "isoenzymes", "(", "CK", "-", "MB", ")", ".", "Assessments", "will", "be", "performed", "at", "baseline", "(", "before", "randomization", ")", "and", "3", ",", "6", ",", "9", ",", "12", ",", "16", ",", "and", "20", "weeks", "after", "randomization", ".", "This", "will", "be", "the", "first", "clinical", "trial", "to", "evaluate", "the", "cardioprotective", "effects", "and", "safety", "of", "P", ".", "grandiflorum", "in", "patients", "with", "early", "breast", "cancer", "receiving", "anthracycline", "-", "based", "chemotherapy", ".", "We", "are", "also", "performing", "this", "trial", "to", "assess", "the", "feasibility", "of", "a", "larger", "-", "scale", "clinical", "trial", "in", "the", "future", ".", "Chinese", "Clinical", "Trial", "Registry", ",", "ChiCTR", "-", "IPR-", "16009256", ".", "Registered", "on", "23", "September", "2016", "." ]

[ 0, 0, 0, 17, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 0, 23, 24, 0, 23, 24, 24, 24, 24, 0, 23, 24, 24, 24, 0, 23, 24, 24, 0, 23, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Twenty", "-", "year", "follow", "-", "up", "of", "the", "Royal", "Marsden", "randomized", ",", "double", "-", "blinded", "tamoxifen", "breast", "cancer", "prevention", "trial", ".", "Several", "clinical", "trials", "have", "reported", "an", "early", "reduction", "in", "breast", "cancer", "incidence", "in", "healthy", "women", "using", "tamoxifen", "to", "reduce", "their", "risk", "of", "breast", "cancer", "but", "have", "not", "reported", "longer", "follow", "-", "up", "data", "for", "the", "evaluation", "of", "breast", "cancer", "prevention", ".", "We", "report", "the", "blinded", "20", "-year", "follow", "-", "up", "(", "median", "follow", "-", "up", "=", "13", "years", ")", "of", "the", "Royal", "Marsden", "trial", "to", "identify", "any", "long", "-", "term", "prevention", "of", "breast", "cancer", "associated", "with", "tamoxifen", "treatment", ".", "We", "randomly", "assigned", "2494", "healthy", "women", "to", "oral", "tamoxifen", "(", "20", "mg", "/", "day", ")", "or", "placebo", "for", "8", "years", ".", "The", "primary", "outcome", "was", "occurrence", "of", "invasive", "breast", "cancer", ".", "A", "secondary", "planned", "analysis", "of", "estrogen", "receptor", "(", "ER", ")", "-positive", "invasive", "breast", "cancer", "was", "also", "done", ".", "Survival", "was", "assessed", "by", "use", "of", "a", "Cox", "proportional", "hazards", "model", "in", "both", "univariate", "and", "multivariable", "analyses", ".", "The", "durability", "of", "the", "treatment", "effect", "was", "assessed", "by", "use", "of", "a", "Cox", "regression", "analysis", ".", "All", "statistical", "tests", "were", "two", "-", "sided", ".", "Among", "the", "2471", "eligible", "participants", "(", "1238", "participants", "in", "the", "tamoxifen", "arm", "and", "1233", "participants", "in", "the", "placebo", "arm", ")", ",", "186", "developed", "invasive", "breast", "cancer", "(", "82", "on", "tamoxifen", "and", "104", "on", "placebo", ";", "hazard", "ratio", "[", "HR", "]", "=", "0.78", ",", "95", "%", "confidence", "interval", "[", "CI", "]", "=", "0.58", "to", "1.04", ";", "P", "=", ".", "1", ")", ".", "Of", "these", "186", "cancers", ",", "139", "were", "ER", "positive", "(", "53", "on", "tamoxifen", "and", "86", "on", "placebo", ";", "HR", "=", "0.61", ",", "95", "%", "CI", "=", "0.43", "to", "0.86", ";", "P", "=", ".", "005", ")", ".", "The", "risk", "of", "ER", "-", "positive", "breast", "cancer", "was", "not", "statistically", "significantly", "lower", "in", "the", "tamoxifen", "arm", "than", "in", "the", "placebo", "arm", "during", "the", "8", "-year", "treatment", "period", "(", "30", "cancers", "in", "the", "tamoxifen", "arm", "and", "39", "in", "the", "placebo", "arm", ";", "HR", "=", "0.77", ",", "95", "%", "CI", "=", "0.48", "to", "1.23", ";", "P", "=", ".", "3", ")", "but", "was", "statistically", "significantly", "lower", "in", "the", "posttreatment", "period", "(", "23", "in", "the", "tamoxifen", "arm", "and", "47", "in", "the", "placebo", "arm", ";", "HR", "=", "0.48", ",", "95", "%", "CI", "=", "0.29", "to", "0.79", ";", "P", "=", ".", "004", ")", ".", "Fifty", "-", "four", "participants", "in", "each", "arm", "have", "died", "from", "any", "cause", "(", "HR", "=", "0.99", ",", "95", "%", "CI", "=", "0.68", "to", "1.44", ";", "P", "=", ".", "95", ")", ".", "The", "adverse", "event", "profiles", "for", "both", "arms", "were", "similar", "to", "those", "previously", "reported", "and", "occurred", "predominantly", "during", "the", "treatment", "period", ".", "A", "statistically", "significant", "reduction", "in", "the", "incidence", "of", "ER", "-", "positive", "breast", "cancer", "was", "observed", "in", "the", "tamoxifen", "arm", "that", "occurred", "predominantly", "during", "the", "post", "treatment", "follow", "-", "up", ",", "indicating", "long", "-", "term", "prevention", "of", "estrogen", "-", "dependent", "breast", "cancer", "by", "tamoxifen", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 9, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 25, 0, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 25, 0, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 25, 0, 0, 0, 0, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 25, 0, 0, 0, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 25, 26, 26, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Bone", "turnover", "markers", "and", "insulin", "-", "like", "growth", "factor", "components", "in", "metastatic", "breast", "cancer", ":", "results", "from", "a", "randomised", "trial", "of", "exemestane", "vs", "megestrol", "acetate", ".", "The", "aim", "of", "this", "randomised", "study", "was", "to", "compare", "the", "effects", "of", "progestins", "and", "aromatase", "inactivators", "on", "bone", "remodelling", "markers", "and", "the", "components", "of", "insulin", "-", "like", "growth", "factor", "in", "patients", "with", "metastatic", "breast", "cancer", ".", "Within", "the", "framework", "of", "a", "large", "(", "769", "patients", ")", ",", "randomised", "double", "-", "blind", "clinical", "trial", "comparing", "exemestane", "(", "EXE", ")", "with", "megestrol", "acetate", "(", "MA", ")", ",", "serum", "17", "beta", "-", "estradiol", "(", "E", "2", ")", ",", "estrone", "(", "E", "1", ")", ",", "estrone", "sulphate", "(", "E", "1", "S", ")", ",", "bone", "alkaline", "phosphatase", "(", "BAP", ")", ",", "carboxy", "-", "terminal", "cross", "-", "linking", "telopeptide", "of", "type", "I", "collagen", "(", "ICTP", ")", "and", "the", "components", "of", "insulin", "-", "like", "growth", "factor", "(", "IGF", ")", "family", "(", "IGF-", "1", ",", "IGF-", "2", "and", "IGFBP-", "3", ")", "were", "determined", "in", "53", "patients", "(", "24", "randomised", "to", "EXE", "and", "29", "ramdomised", "to", "MA", ")", ".", "After", "eight", "weeks", "of", "treatment", ",", "both", "ICTP", "and", "BAP", "increased", "(", "p", "<", "0.01", ")", "in", "the", "EXE", "group", ",", "but", "only", "ICTP", "in", "the", "MA", "group", "(", "p", "<", "0.03", ")", ".", "The", "8", "-week", "suppression", "of", "E", "2", "and", "E", "1", "S", "was", "more", "pronounced", "in", "the", "EXE", "group", "(", "to", ",", "respectively", ",", "11.2", "%", "and", "9.9", "%", "of", "baseline", "values", ")", "than", "in", "the", "MA", "group", "(", "33.1", "%", "and", "29.7", "%", ")", ".", "IGF-", "1", "increased", "(", "p", "<", "0.01", ")", "in", "both", "groups", ",", "but", "more", "so", "in", "the", "patients", "treated", "with", "MA", ".", "Estrogen", "levels", "negatively", "correlated", "with", "ICTP", "in", "both", "groups", ",", "but", "were", "not", "related", "to", "BAP", "in", "either", ".", "IGF-", "1", "negatively", "correlated", "with", "estrogens", "in", "both", "groups", ".", "The", "results", "of", "this", "study", "indicate", "that", "anti", "-", "aromatase", "therapy", "is", "associated", "with", "increased", "osteoclast", "activity", ",", "and", "suggest", "the", "existence", "of", "possible", "differential", "effects", "of", "different", "hormonal", "therapies", "on", "bone", "remodelling", "markers", "regardless", "of", "the", "estrogen", "suppression", "induced", "by", "EXE", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 3, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "[", "A", "multicenter", ",", "randomized", ",", "controlled", ",", "phase", "Ⅲ", "clinical", "study", "of", "PEG", "-", "rhG", "-", "CSF", "for", "preventing", "chemotherapy", "-", "induced", "neutropenia", "in", "patients", "with", "breast", "cancer", "and", "non", "-", "small", "cell", "lung", "cancer", "]", ".", "To", "explore", "the", "safety", "and", "efficacy", "of", "pegylated", "recombinant", "human", "granulocyte", "colony", "-", "stimulating", "factor", "(", "PEG", "-", "rhG", "-", "CSF", ")", "in", "preventing", "chemotherapy", "-", "induced", "neutropenia", "in", "patients", "with", "breast", "cancer", "and", "non", "-", "small", "cell", "lung", "cancer", "(", "NSCLC", ")", ",", "and", "to", "provide", "the", "basis", "for", "clinical", "application", ".", "According", "to", "the", "principle", "of", "open", "-", "label", ",", "randomized", ",", "parallel", "-", "group", "controlled", "clinical", "trial", ",", "all", "patients", "were", "randomized", "by", "1", "∶", "1", "∶", "1", "into", "three", "groups", "to", "receive", "PEG", "-", "rhG", "-", "CSF", "100", "μg", "/", "kg", ",", "PEG", "-", "rhG", "-", "CSF", "6", "mg", ",", "or", "rhG", "-", "CSF", "5", "μg", "/", "kg", ",", "respectively", ".", "The", "patients", "with", "breast", "cancer", "received", "two", "chemotherapy", "cycles", ",", "and", "the", "NSCLC", "patients", "received", "1", "-", "2", "cycles", "of", "chemotherapy", "according", "to", "their", "condition", ".", "All", "patients", "were", "treated", "with", "the", "combination", "chemotherapy", "of", "TAC", "(", "docetaxel+", "epirubicin+", "cyclophosphamide", ")", "or", "TA", "(", "docetaxel+", "epirubicin", ")", ",", "or", "the", "chemotherapy", "of", "docetaxel", "combined", "with", "carboplatin", ",", "with", "a", "21", "day", "cycle", ".", "The", "duration", "of", "grade", "3", "-", "4", "neutropenia", "in", "the", "PEG", "-", "rhG", "-", "CSF", "100", "μg", "/", "kg", "and", "PEG", "-", "rhG", "-", "CSF", "6", "mg", "groups", "were", "similar", "with", "that", "in", "the", "rhG", "-", "CSF", "5", "μg", "/", "kg", "group", "(", "P", ">", "0.05", "for", "all", ")", ".", "The", "incidence", "rate", "of", "grade", "3", "-", "4", "neutropenia", "in", "the", "PEG", "-", "rhG", "-", "CSF", "100", "μg", "/", "kg", "group", ",", "PEG", "-", "rhG", "-", "CSF", "6", "mg", "group", ",", "and", "G", "-", "CSF", "5", "μg", "/", "kg", "group", "were", "69.7", "%", ",", "68.4", "%", ",", "and", "69.5", "%", ",", "respectively", ",", "with", "a", "non", "-", "significant", "difference", "among", "the", "three", "groups", "(", "P=", "0.963", ")", ".", "The", "incidence", "rate", "of", "febrile", "neutropenia", "in", "the", "PEG", "-", "rhG", "-", "CSF", "100", "μg", "/", "kg", "group", ",", "PEG", "-", "rhG", "-", "CSF", "6", "mg", "group", "and", "G", "-", "CSF", "5", "μg", "/", "kg", "group", "were", "6.1", "%", ",", "6.4", "%", ",", "and", "5.5", "%", ",", "respectively", ",", "showing", "no", "significant", "difference", "among", "them", "(", "P=", "0.935", ")", ".", "The", "incidence", "rate", "of", "adverse", "events", "in", "the", "PEG", "-", "rhG", "-", "CSF", "100", "μg", "/", "kg", "group", ",", "PEG", "-", "rhG", "-", "CSF", "6", "mg", "group", "and", "G", "-", "CSF", "5", "μg", "/", "kg", "group", "were", "6.7", "%", ",", "4.1", "%", ",", "and", "5.5", "%", ",", "respectively", ",", "showing", "a", "non", "-", "significant", "difference", "among", "them", "(", "P=", "0.581", ")", ".", "In", "patients", "with", "breast", "cancer", "and", "non", "-", "small", "cell", "lung", "cancer", "(", "NSCLC", ")", "undergoing", "TAC", "/", "TA", "chemotherapy", ",", "a", "single", "100", "μg", "/", "kg", "injection", "or", "a", "single", "fixed", "6", "mg", "dose", "of", "PEG", "-", "rhG", "-", "CSF", "at", "48", "hours", "after", "chemotherapy", "show", "definite", "therapeutic", "effect", "with", "a", "low", "incidence", "of", "adverse", "events", "and", "mild", "adverse", "reactions", ".", "Compared", "with", "the", "continuous", "daily", "injection", "of", "rhG", "-", "CSF", "5", "μg", "/", "kg", "/", "d", ",", "a", "single", "100", "μg", "/", "kg", "injection", "or", "a", "single", "fixed", "6", "mg", "dose", "of", "PEG", "-", "rhG", "-", "CSF", "has", "similar", "effect", "and", "is", "more", "advantageous", "in", "preventing", "chemotherapy", "-", "induced", "neutropenia", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 29, 30, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 29, 30, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 29, 30, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Comparison", "of", "anastrozole", "versus", "tamoxifen", "as", "preoperative", "therapy", "in", "postmenopausal", "women", "with", "hormone", "receptor", "-", "positive", "breast", "cancer", ":", "the", "Pre", "-", "Operative", "\"", "Arimidex", "\"", "Compared", "to", "Tamoxifen", "(", "PROACT", ")", "trial", ".", "The", "Pre", "-", "Operative", "\"", "Arimidex", "\"", "Compared", "to", "Tamoxifen", "(", "PROACT", ")", "study", "was", "a", "randomized", ",", "multicenter", "study", "comparing", "anastrozole", "with", "tamoxifen", "as", "a", "preoperative", "treatment", "of", "postmenopausal", "women", "with", "large", ",", "operable", "(", "T", "2", "/", "3", ",", "N", "0", "-", "2", ",", "M", "0", ")", ",", "or", "potentially", "operable", "(", "T", "4", "b", ",", "N", "0", "-", "2", ",", "M", "0", ")", "breast", "cancer", ".", "The", "effect", "of", "preoperative", "endocrine", "therapy", "in", "patients", "scheduled", "for", "mastectomy", "or", "with", "inoperable", "tumors", "at", "baseline", "was", "also", "investigated", ".", "Patients", "with", "hormone", "receptor", "-", "positive", "breast", "cancer", "received", "anastrozole", "(", "n", "=", "228", ")", "or", "tamoxifen", "(", "n", "=", "223", ")", "with", "or", "without", "chemotherapy", "for", "12", "weeks", "before", "primary", "surgery", ".", "Objective", "responses", "for", "anastrozole", "and", "tamoxifen", "occurred", "in", "39.5", "%", "and", "35.4", "%", "of", "patients", ",", "respectively", "(", "ultrasound", "measurements", ")", ",", "and", "50.0", "%", "and", "46.2", "%", "of", "patients", ",", "respectively", "(", "caliper", "measurements", ")", ".", "In", "hormonal", "therapy", "-", "only", "patients", "(", "n", "=", "314", ")", ",", "feasible", "surgery", "at", "baseline", "improved", "after", "3", "months", "in", "43.0", "%", "of", "patients", "receiving", "anastrozole", "and", "30.8", "%", "receiving", "tamoxifen", "(", "P", "=", ".", "04", ")", ".", "In", "the", "intent", "-", "to", "-", "treat", "population", ",", "improvement", "in", "feasible", "surgery", "at", "baseline", "to", "actual", "surgery", "at", "3", "months", "was", "found", "to", "be", "numerically", "higher", "in", "the", "anastrozole", "group", "compared", "with", "the", "tamoxifen", "group", ",", "although", "this", "difference", "did", "not", "reach", "significance", ".", "Drug", "-", "related", "adverse", "events", "were", "reported", "in", "20.2", "%", "and", "18.1", "%", "of", "patients", ",", "respectively", ",", "in", "the", "anastrozole", "and", "tamoxifen", "groups", ".", "Anastrozole", "is", "an", "effective", "and", "well", "-", "tolerated", "preoperative", "therapy", ",", "producing", "clinically", "beneficial", "tumor", "downstaging", "and", "reductions", "in", "tumor", "volume", ".", "These", "effects", "enable", "more", "minimal", "surgical", "interventions", "in", "patients", "scheduled", "for", "mastectomy", ",", "and", "mastectomy", "in", "patients", "with", "previously", "inoperable", "tumors", ".", "Anastrozole", "appears", "to", "be", "at", "least", "as", "effective", "as", "tamoxifen", "in", "this", "setting", ",", "and", "more", "effective", "than", "tamoxifen", "in", "certain", "clinically", "relevant", "subgroups", ".", "Cancer", "2006", ".", "(", "c", ")", "2006", "American", "Cancer", "Society", "." ]

[ 0, 0, 17, 0, 19, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 21, 22, 22, 0, 29, 30, 0, 0, 0, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "randomized", "phase", "II", "trial", "comparing", "preoperative", "plus", "perioperative", "chemotherapy", "with", "preoperative", "chemotherapy", "in", "patients", "with", "locally", "advanced", "breast", "cancer", ".", "The", "aim", "of", "this", "study", "was", "to", "investigate", "in", "a", "randomized", "trial", "the", "activity", "of", "perioperative", "chemotherapy", "in", "patients", "treated", "with", "preoperative", "chemotherapy", "for", "locally", "advanced", "breast", "cancer", "and", "to", "compare", "it", "with", "the", "preoperative", "chemotherapy", "alone", ".", "Patients", "with", "cT", "2", "-", "3", "N", "0", "-", "2", "M", "0", "histologically", "proven", "breast", "cancer", ",", "with", "estrogen", "receptors", "and", "progesterone", "receptors", "in", "less", "than", "20", "%", "of", "cells", ",", "or", "with", "absence", "of", "progesterone", "receptors", ",", "received", "epirubicin", "25", "mg", "/", "m", "days", "1", "and", "2", ",", "cisplatin", "60", "mg", "/", "m", "day", "1", ",", "and", "fluorouracil", "200", "mg", "/", "m", "daily", "as", "continuous", "infusion", ".", "Responding", "patients", "were", "randomized", "to", "continue", "fluorouracil", "until", "2", "weeks", "after", "surgery", "(", "perioperative", "chemotherapy", ")", "or", "to", "stop", "fluorouracil", "1", "week", "before", "surgery", ".", "Fifty", "-", "eight", "patients", "completed", "six", "courses", "of", "epirubicin", ",", "cisplatin", "and", "fluorouracil", ",", "and", "were", "randomized", "to", "perioperative", "chemotherapy", "(", "29", "patients", ")", "or", "to", "control", "(", "29", "patients", ")", ".", "The", "median", "Ki-", "67", "index", "remained", "stable", "(", "32", "-", "27.5", "%", ")", "in", "the", "perioperative", "chemotherapy", "arm", "(", "P=", "0.3", ")", "and", "decreased", "from", "55", "to", "22.5", "%", "in", "the", "control", "arm", "(", "P=", "0.01", ")", ".", "The", "rate", "of", "pathological", "complete", "remission", "was", "41", "%", "in", "both", "arms", "(", "P=", "1.0", ")", ".", "No", "significant", "difference", "in", "terms", "of", "disease", "-", "free", "survival", "and", "overall", "survival", "was", "observed", "between", "the", "two", "arms", ".", "Perioperative", "chemotherapy", "failed", "to", "show", "an", "increase", "in", "the", "pathological", "complete", "remission", "rate", ".", "A", "biological", "effect", "on", "Ki-", "67", "expression", "was", "demonstrated", "." ]

[ 0, 0, 0, 0, 0, 0, 17, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 19, 0, 5, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Differential", "effects", "of", "metformin", "on", "breast", "cancer", "proliferation", "according", "to", "markers", "of", "insulin", "resistance", "and", "tumor", "subtype", "in", "a", "randomized", "presurgical", "trial", ".", "Treatment", "of", "diabetics", "with", "metformin", "is", "associated", "with", "decreased", "breast", "cancer", "risk", "in", "observational", "studies", ",", "but", "it", "remains", "unclear", "if", "this", "drug", "has", "clinical", "antineoplastic", "activity", ".", "In", "a", "recent", "presurgical", "trial", ",", "we", "found", "a", "heterogeneous", "effect", "of", "metformin", "on", "breast", "cancer", "proliferation", "(", "ki-", "67", ")", "depending", "upon", "insulin", "resistance", "(", "HOMA", "index", ")", ".", "Here", ",", "we", "determined", "the", "associations", "of", "additional", "serum", "biomarkers", "of", "insulin", "resistance", ",", "tumor", "subtype", ",", "and", "drug", "concentration", "with", "ki-", "67", "response", "to", "metformin", ".", "Two", "-", "hundred", "non", "-", "diabetic", "women", "were", "randomly", "allocated", "to", "metformin", "(", "850", "mg", "/", "bid", ")", "or", "placebo", "for", "4", "weeks", "prior", "to", "breast", "cancer", "surgery", ".", "The", "ki-", "67", "response", "to", "metformin", "was", "assessed", "comparing", "data", "obtained", "from", "baseline", "biopsy", "(", "ki-", "67", "and", "tumor", "subtype", ")", "and", "serum", "markers", "(", "HOMA", "index", ",", "C", "-", "peptide", ",", "IGF", "-", "I", ",", "IGFBP-", "1", ",", "IGFBP-", "3", ",", "free", "IGF", "-", "I", ",", "hs", "-", "CRP", ",", "adiponectin", ")", "with", "the", "same", "measurements", "at", "definitive", "surgery", ".", "For", "patients", "with", "a", "blood", "sample", "taken", "within", "24", "h", "from", "last", "drug", "intake", ",", "metformin", "level", "was", "measured", ".", "Compared", "with", "placebo", ",", "metformin", "significantly", "decreased", "ki-", "67", "in", "women", "with", "HOMA", ">", "2.8", ",", "those", "in", "the", "lowest", "IGFBP-", "1", "quintile", ",", "those", "in", "the", "highest", "IGFBP-", "3", "quartile", ",", "those", "with", "low", "free", "IGF", "-", "I", ",", "those", "in", "the", "top", "hs", "-", "CRP", "tertile", ",", "and", "those", "with", "HER", "2", "-", "positive", "tumors", ".", "In", "women", "with", "HOMA", "index", ">", "2.8", ",", "drug", "levels", "were", "positively", "correlated", "with", "the", "ki-", "67", "decrease", ",", "whereas", "no", "trend", "was", "noted", "in", "women", "with", "HOMA", "<", "2.8", "(", "p", "-", "interaction", "=", "0.07", ")", ".", "At", "conventional", "antidiabetic", "doses", ",", "the", "effect", "of", "metformin", "on", "tumor", "ki-", "67", "of", "non", "-", "diabetic", "breast", "cancer", "patients", "varies", "with", "host", "and", "tumor", "characteristics", ".", "These", "findings", "are", "relevant", "to", "design", "breast", "cancer", "prevention", "and", "treatment", "trials", "with", "metformin", "." ]

[ 0, 0, 0, 17, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 9, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Quality", "of", "Life", "of", "Women", "After", "a", "First", "Diagnosis", "of", "Breast", "Cancer", "Using", "a", "Self", "-", "Management", "Support", "mHealth", "App", "in", "Taiwan", ":", "Randomized", "Controlled", "Trial", ".", "There", "are", "over", "2", "million", "newly", "diagnosed", "patients", "with", "breast", "cancer", "worldwide", "with", "more", "than", "10", ",", "000", "cases", "in", "Taiwan", "each", "year", ".", "During", "2017", "-", "2018", ",", "the", "National", "Yang", "-", "Ming", "University", ",", "the", "Taiwan", "University", "of", "Science", "and", "Technology", ",", "and", "the", "Taiwan", "Breast", "Cancer", "Prevention", "Foundation", "collaborated", "to", "develop", "a", "breast", "cancer", "self", "-", "management", "support", "(", "BCSMS", ")", "mHealth", "app", "for", "Taiwanese", "women", "with", "breast", "cancer", ".", "The", "aim", "of", "this", "study", "was", "to", "investigate", "the", "quality", "of", "life", "(", "QoL", ")", "of", "women", "with", "breast", "cancer", "in", "Taiwan", "after", "using", "the", "BCSMS", "app", ".", "After", "receiving", "a", "first", "diagnosis", "of", "breast", "cancer", ",", "women", "with", "stage", "0", "to", "III", "breast", "cancer", ",", "who", "were", "recruited", "from", "social", "networking", "sites", "or", "referred", "by", "their", "oncologists", "or", "oncology", "case", "managers", ",", "were", "randomized", "1", ":1", "into", "intervention", "and", "control", "groups", ".", "Intervention", "group", "subjects", "used", "the", "BCSMS", "app", "and", "the", "control", "group", "subjects", "received", "usual", "care", ".", "Two", "questionnaires", "-", "the", "European", "Organization", "for", "Research", "and", "Treatment", "of", "Cancer", "(", "EORTC", ")", "Quality", "-", "of", "-", "Life", "Questionnaire", "Core", "30", "(", "QLQ", "-", "C", "30", ")", "and", "the", "EORTC", "Breast", "Cancer", "-", "Specific", "Quality", "-", "of", "-", "Life", "Questionnaire", "(", "QLQ", "-", "BR", "23", ")", "-were", "distributed", "to", "subjects", "in", "both", "arms", ".", "Paper", "-", "based", "questionnaires", "were", "used", "at", "baseline", ";", "paper", "-", "based", "or", "Web", "-", "based", "questionnaires", "were", "used", "at", "1.5", "-month", "and", "3", "-month", "follow", "-", "up", "evaluations", ".", "All", "evaluations", "were", "self", "-", "assessed", "and", "anonymous", ",", "and", "participants", "were", "blinded", "to", "their", "allocation", "groups", ".", "Descriptive", "analysis", ",", "the", "Pearson", "chi", "-", "square", "test", ",", "analysis", "of", "variance", ",", "and", "the", "generalized", "estimating", "equation", "were", "used", "to", "analyze", "the", "data", ".", "Missing", "values", ",", "with", "and", "without", "multi", "-", "imputation", "techniques", ",", "were", "used", "for", "sensitivity", "analysis", ".", "A", "total", "of", "112", "women", "were", "enrolled", "and", "randomly", "allocated", "to", "either", "the", "experimental", "group", "(", "n=", "53", ")", "or", "control", "group", "(", "n=", "59", ")", ".", "The", "follow", "-", "up", "completion", "rate", "was", "89.3", "%", "(", "100", "/", "112", ")", ".", "The", "demographic", "data", "showed", "homogeneity", "between", "the", "two", "groups", "in", "age", "(", "range", "50", "-", "64", "years", ")", ",", "breast", "cancer", "stage", "(", "stage", "II", ")", ",", "marital", "status", "(", "married", ")", ",", "working", "status", "(", "employed", ")", ",", "and", "treatment", "status", "(", "receiving", "treatments", ")", ".", "The", "mean", "total", "QoL", "summary", "scores", "from", "the", "QLQ", "-", "C", "30", "(", "83.45", "vs", "82.23", ",", "P=", ".", "03", ")", "and", "the", "QLQ", "-", "BR", "23", "(", "65.53", "vs", "63.13", ",", "P=", ".", "04", ")", "were", "significantly", "higher", "among", "the", "experimental", "group", "versus", "the", "control", "group", ",", "respectively", ",", "at", "3", "months", ".", "This", "research", "provides", "support", "for", "using", "a", "mobile", "health", "care", "app", "to", "promote", "the", "QoL", "among", "women", "in", "Taiwan", "after", "a", "first", "diagnosis", "of", "breast", "cancer", ".", "The", "BCSMS", "app", "could", "be", "used", "to", "support", "disease", "self", "-", "management", ",", "and", "further", "evaluation", "of", "whether", "QoL", "is", "sustained", "is", "warranted", ".", "ClinicalTrials.gov", "NCT", "004174248", ";", "https://clinicaltrials.gov/ct2/show/NCT", "04174248", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 18, 18, 18, 0, 15, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 11, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 21, 22, 22, 22, 0, 33, 0, 35, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 33, 0, 35, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "[", "Randomized", "controlled", "trial", "of", "two", "kinds", "of", "home", "-", "produced", "docetaxel", "in", "China", "for", "advanced", "breast", "cancer", "]", ".", "Two", "kinds", "of", "home", "-", "produced", "docetaxel", "in", "China", ",", "injection", "Yiyoutasai", "and", "injection", "Aisu", ",", "have", "the", "same", "structure", ".", "Data", "from", "preclinical", "study", "had", "shown", "that", "injection", "Yiyoutasai", "has", "the", "same", "pharmacokinetics", "and", "toxicity", "as", "injection", "Aisu", ".", "This", "study", "was", "to", "evaluate", "the", "efficacy", "and", "toxicity", "of", "injection", "Yiyoutasai", "in", "treating", "advanced", "breast", "cancer", ".", "Eligible", "breast", "cancer", "patients", "were", "enrolled", "and", "randomly", "assigned", "to", "study", "group", "and", "control", "group", ",", "and", "received", "injection", "of", "75", "mg", "/", "m", "(", "2", ")", "Yiyoutasai", "or", "Aisu", ",", "respectively", ".", "The", "injections", "were", "repeated", "every", "3", "weeks", ".", "All", "patients", "received", "at", "least", "2", "cycles", ".", "The", "efficacy", "of", "Yiyoutasai", "and", "Aisu", "were", "evaluated", "after", "treatment", ".", "A", "total", "of", "67", "patients", "were", "enrolled", ":", "33", "in", "study", "group", ",", "and", "34", "in", "control", "group", ".", "Of", "the", "31", "evaluable", "cases", "in", "study", "group", ",", "1", "achieved", "complete", "remission", "(", "CR", ")", ",", "9", "achieved", "partial", "remission", "(", "PR", ")", ",", "11", "had", "stable", "disease", "(", "SD", ")", ",", "and", "10", "had", "progressive", "disease", "(", "PD", ")", ";", "the", "total", "response", "rate", "was", "22.22", "%", ".", "There", "were", "1", "CR", ",", "5", "PR", ",", "19", "SD", ",", "and", "9", "PD", "in", "control", "group", ";", "the", "total", "response", "rate", "was", "15.15", "%", ".", "There", "was", "no", "significant", "difference", "between", "the", "2", "groups", "(", "P=", "0.662", ")", ".", "The", "median", "follow", "-", "up", "was", "16.5", "months", "(", "8", "-", "28", "months", ")", ".", "In", "study", "group", ",", "the", "median", "progression", "-", "free", "survival", "time", "was", "6.2", "months", "(", "2", "-", "12", "months", ")", ",", "the", "1", "-year", "survival", "rate", "was", "68.51", "%", ",", "and", "the", "2", "-year", "survival", "rate", "was", "40.12", "%", ";", "in", "control", "group", ",", "the", "median", "progression", "-", "free", "survival", "time", "was", "7.1", "months", "(", "2.3", "-", "11", "months", ")", ",", "the", "1", "-year", "survival", "rate", "was", "65.23", "%", ",", "and", "the", "2", "-year", "survival", "rate", "was", "39.71", "%", ".", "There", "was", "no", "significant", "difference", "between", "the", "2", "groups", "(", "P=", "0.102", ",", "0.098", ",", "0.089", ",", "respectively", ")", ".", "Common", "adverse", "events", "were", "myelosuppression", ",", "transient", "transaminase", "elevation", ",", "and", "alopecia", ".", "One", "patient", "in", "study", "group", "suffered", "from", "severe", "allergic", "reaction", "after", "infusion", ",", "1", "in", "control", "group", "suffered", "from", "whole", "body", "edema", ".", "Yiyoutasai", "and", "Aisu", "have", "similar", "efficacy", "on", "and", "toxicity", "to", "advanced", "breast", "cancer", "patients", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 18, 0, 15, 0, 9, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 0, 19, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 25, 0, 21, 22, 22, 22, 22, 0, 25, 0, 21, 22, 22, 22, 22, 0, 25, 0, 21, 22, 22, 22, 22, 0, 0, 25, 0, 21, 22, 22, 22, 22, 0, 0, 21, 22, 22, 0, 29, 30, 0, 0, 0, 27, 21, 0, 27, 21, 0, 27, 21, 0, 0, 27, 21, 0, 0, 0, 0, 0, 21, 22, 22, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 37, 38, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 29, 30, 0, 0, 0, 21, 22, 22, 22, 0, 29, 30, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 39, 40, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 31, 32, 0, 0, 0, 21, 22, 22, 22, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 21, 22, 22, 22, 22, 22, 22, 22, 0, 25, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 27, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Efficacy", "of", "everolimus", "with", "exemestane", "versus", "exemestane", "alone", "in", "Asian", "patients", "with", "HER", "2", "-", "negative", ",", "hormone", "-", "receptor", "-", "positive", "breast", "cancer", "in", "BOLERO-", "2", ".", "The", "addition", "of", "mTOR", "inhibitor", "everolimus", "(", "EVE", ")", "to", "exemestane", "(", "EXE", ")", "was", "evaluated", "in", "an", "international", ",", "phase", "3", "study", "(", "BOLERO-", "2", ")", "in", "patients", "with", "hormone", "-", "receptor", "-", "positive", "(", "HR", "(", "+", ")", ")", "breast", "cancer", "refractory", "to", "letrozole", "or", "anastrozole", ".", "The", "safety", "and", "efficacy", "of", "anticancer", "treatments", "may", "be", "influenced", "by", "ethnicity", "(", "Sekine", "et", "al", ".", "in", "Br", "J", "Cancer", "99", ":", "1757", "-", "62", ",", "2008", ")", ".", "Safety", "and", "efficacy", "results", "from", "Asian", "versus", "non", "-", "Asian", "patients", "in", "BOLERO-", "2", "are", "reported", ".", "Patients", "were", "randomized", "(", "2", ":1", ")", "to", "10", "mg", "/", "day", "EVE", "+", "EXE", "or", "placebo", "(", "PBO", ")", "+", "EXE", ".", "Primary", "endpoint", "was", "progression", "-", "free", "survival", "(", "PFS", ")", ".", "Secondary", "endpoints", "included", "overall", "survival", ",", "response", "rate", ",", "clinical", "benefit", "rate", ",", "and", "safety", ".", "Of", "143", "Asian", "patients", ",", "98", "received", "EVE", "+", "EXE", "and", "45", "received", "PBO", "+", "EXE", ".", "Treatment", "with", "EVE", "+", "EXE", "significantly", "improved", "median", "PFS", "versus", "PBO", "+", "EXE", "among", "Asian", "patients", "by", "38", "%", "(", "HR", "=", "0.62", ";", "95", "%", "CI", ",", "0.41", "-", "0.94", ")", ".", "Median", "PFS", "was", "also", "improved", "among", "non", "-", "Asian", "patients", "by", "59", "%", "(", "HR", "=", "0.41", ";", "95", "%", "CI", ",", "0.33", "-", "0.50", ")", ".", "Median", "PFS", "duration", "among", "EVE", "-", "treated", "Asian", "patients", "was", "8.48", "versus", "4.14", "months", "for", "PBO", "+", "EXE", ",", "and", "7.33", "versus", "2.83", "months", ",", "respectively", ",", "in", "non", "-", "Asian", "patients", ".", "The", "most", "common", "grade", "3", "/", "4", "adverse", "events", "(", "stomatitis", ",", "anemia", ",", "elevated", "liver", "enzymes", ",", "hyperglycemia", ",", "and", "dyspnea", ")", "occurred", "at", "similar", "frequencies", "in", "Asian", "and", "non", "-", "Asian", "patients", ".", "Grade", "1", "/", "2", "interstitial", "lung", "disease", "occurred", "more", "frequently", "in", "Asian", "patients", ".", "Quality", "of", "life", "was", "similar", "between", "treatment", "arms", "in", "Asian", "patients", ".", "Adding", "EVE", "to", "EXE", "provided", "substantial", "clinical", "benefit", "in", "both", "Asian", "and", "non", "-", "Asian", "patients", "with", "similar", "safety", "profiles", ".", "This", "combination", "represents", "an", "improvement", "in", "the", "management", "of", "postmenopausal", "women", "with", "HR", "(", "+", ")", "/", "HER", "2", "(", "-", ")", "advanced", "breast", "cancer", "progressing", "on", "nonsteroidal", "aromatase", "inhibitors", ",", "regardless", "of", "ethnicity", "." ]

[ 0, 0, 17, 18, 18, 0, 19, 20, 0, 11, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 11, 12, 12, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 20, 20, 20, 20, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 23, 24, 0, 23, 24, 0, 23, 24, 24, 0, 0, 23, 0, 0, 1, 0, 0, 0, 3, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 37, 0, 39, 40, 0, 0, 0, 0, 0, 0, 37, 0, 39, 40, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]