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403 | [
"Expressive",
"writing",
"in",
"early",
"breast",
"cancer",
"survivors",
".",
"This",
"article",
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"-",
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"-",
"life",
"of",
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"breast",
"cancer",
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".",
"An",
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"or",
"not",
"the",
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"writing",
"prompt",
"makes",
"a",
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".",
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"the",
"time",
"of",
"a",
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"diagnosis",
".",
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".",
"Randomized",
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".",
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"(",
"n",
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",",
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"-",
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"minutes",
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".",
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"-",
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",",
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",",
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404 | [
"[",
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"of",
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"-",
"dose",
"carvedilol",
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"with",
"candesartan",
"on",
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"]",
".",
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"-",
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".",
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"-",
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405 | [
"Preoperative",
"dexamethasone",
"reduces",
"postoperative",
"pain",
",",
"nausea",
"and",
"vomiting",
"following",
"mastectomy",
"for",
"breast",
"cancer",
".",
"Dexamethasone",
"has",
"been",
"reported",
"to",
"reduce",
"postoperative",
"symptoms",
"after",
"different",
"surgical",
"procedures",
".",
"We",
"evaluated",
"the",
"efficacy",
"of",
"preoperative",
"dexamethasone",
"in",
"ameliorating",
"postoperative",
"nausea",
"and",
"vomiting",
"(",
"PONV",
")",
",",
"and",
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"after",
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".",
"In",
"this",
"prospective",
",",
"double",
"-",
"blind",
",",
"placebo",
"-",
"controlled",
"study",
",",
"70",
"patients",
"scheduled",
"for",
"mastectomy",
"with",
"axillary",
"lymph",
"node",
"dissection",
"were",
"analyzed",
"after",
"randomization",
"to",
"treatment",
"with",
"8",
"mg",
"intravenous",
"dexamethasone",
"(",
"n",
"=",
"35",
")",
"or",
"placebo",
"(",
"n",
"=",
"35",
")",
".",
"All",
"patients",
"underwent",
"standardized",
"procedures",
"for",
"general",
"anesthesia",
"and",
"surgery",
".",
"Episodes",
"of",
"PONV",
"and",
"pain",
"score",
"were",
"recorded",
"on",
"a",
"visual",
"analogue",
"scale",
".",
"Analgesic",
"and",
"antiemetic",
"requirements",
"were",
"also",
"recorded",
".",
"Demographic",
"and",
"medical",
"variables",
"were",
"similar",
"between",
"groups",
".",
"The",
"incidence",
"of",
"PONV",
"was",
"lower",
"in",
"the",
"dexamethasone",
"group",
"at",
"the",
"early",
"postoperative",
"evaluation",
"(",
"28.6",
"%",
"vs.",
"60",
"%",
";",
"p",
"=",
"0.02",
")",
"and",
"at",
"6",
"h",
"(",
"17.2",
"%",
"vs.",
"45.8",
"%",
";",
"p",
"=",
"0.03",
")",
".",
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"patients",
"in",
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"placebo",
"group",
"required",
"additional",
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"medication",
"(",
"21",
"vs.",
"8",
";",
"p",
"=",
"0.01",
")",
".",
"Dexamethasone",
"treatment",
"significantly",
"reduced",
"postoperative",
"pain",
"just",
"after",
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"(",
"VAS",
"score",
",",
"4.54",
"±",
"1.55",
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"5.83",
"±",
"2.00",
";",
"p",
"=",
"0.004",
")",
",",
"at",
"6",
"h",
"(",
"3.03",
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"1.20",
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"4.17",
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";",
"p",
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")",
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"12",
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"(",
"2.09",
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"2.54",
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";",
"p",
"=",
"0.04",
")",
".",
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"patients",
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"the",
"control",
"group",
"(",
"21",
"vs.",
"10",
";",
"p",
"=",
"0.008",
")",
".",
"There",
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"no",
"adverse",
"events",
",",
"morbidity",
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"mortality",
".",
"Preoperative",
"intravenous",
"dexamethasone",
"(",
"8",
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")",
"can",
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"reduce",
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"incidence",
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"pain",
"in",
"patients",
"undergoing",
"mastectomy",
"with",
"axillary",
"dissection",
"for",
"breast",
"cancer",
".",
"NCT",
"01116713",
"."
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406 | [
"Cost",
"-",
"benefit",
"analysis",
"of",
"a",
"follow",
"-",
"up",
"program",
"in",
"patients",
"with",
"breast",
"cancer",
":",
"a",
"randomized",
"prospective",
"study",
".",
"Increasing",
"the",
"number",
"of",
"breast",
"cancer",
"patients",
"in",
"follow",
"-",
"up",
"involves",
"increased",
"costs",
"and",
",",
"with",
"limited",
"health",
"care",
"resources",
",",
"there",
"is",
"a",
"need",
"to",
"evaluate",
"the",
"cost",
"-",
"benefit",
"to",
"the",
"patient",
"of",
"follow",
"-",
"up",
"regimens",
".",
"We",
"present",
"a",
"randomized",
"prospective",
"study",
"to",
"evaluate",
"the",
"cost",
"-",
"benefit",
"of",
"intensive",
"follow",
"-",
"up",
"in",
"the",
"early",
"detection",
"of",
"relapses",
"in",
"patients",
"with",
"breast",
"cancer",
".",
"One",
"hundred",
"and",
"twenty",
"-",
"one",
"patients",
"were",
"randomized",
"to",
"standard",
"clinical",
"follow",
"-",
"up",
"(",
"n=",
"63",
")",
"or",
"to",
"an",
"intensive",
"follow",
"-",
"up",
"(",
"n=",
"58",
")",
"that",
"included",
"diagnostic",
"laboratory",
"tests",
"and",
"imaging",
"designed",
"to",
"detect",
"early",
"relapse",
"following",
"curative",
"treatment",
".",
"All",
"patients",
"had",
"annual",
"mammography",
".",
"The",
"number",
"of",
"scheduled",
"outpatient",
"appointments",
"kept",
"were",
"359",
"in",
"the",
"standard",
"clinical",
"follow",
"-",
"up",
"and",
"355",
"in",
"the",
"intensive",
"follow",
"-",
"up",
"group",
".",
"After",
"a",
"median",
"of",
"3",
"years",
"of",
"follow",
"-",
"up",
",",
"there",
"were",
"28",
"relapses",
",",
"11",
"in",
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"clinical",
"follow",
"-",
"up",
",",
"and",
"13",
"in",
"the",
"intensive",
"follow",
"-",
"up",
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".",
"The",
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"of",
"follow",
"-",
"up",
"was",
"24",
",",
"567",
"euros",
"in",
"the",
"standard",
"clinical",
"follow",
"-",
"up",
"group",
"and",
"74",
",",
"171",
"euros",
"in",
"the",
"intensive",
"follow",
"-",
"up",
"group",
".",
"Performing",
"complimentary",
"investigations",
"in",
"breast",
"cancer",
"follow",
"-",
"up",
"is",
"associated",
"with",
"higher",
"costs",
"without",
"difference",
"in",
"early",
"detection",
"of",
"relapses",
"."
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407 | [
"Tamoxifen",
"with",
"or",
"without",
"breast",
"irradiation",
"in",
"women",
"50",
"years",
"of",
"age",
"or",
"older",
"with",
"early",
"breast",
"cancer",
".",
"We",
"determined",
"the",
"effect",
"of",
"breast",
"irradiation",
"plus",
"tamoxifen",
"on",
"disease",
"-",
"free",
"survival",
"and",
"local",
"relapse",
"in",
"women",
"50",
"years",
"of",
"age",
"or",
"older",
"who",
"had",
"T",
"1",
"or",
"T",
"2",
"node",
"-",
"negative",
"breast",
"cancer",
".",
"Between",
"December",
"1992",
"and",
"June",
"2000",
",",
"769",
"women",
"with",
"early",
"breast",
"cancer",
"(",
"tumor",
"diameter",
",",
"5",
"cm",
"or",
"less",
")",
"were",
"randomly",
"assigned",
"to",
"receive",
"breast",
"irradiation",
"plus",
"tamoxifen",
"(",
"386",
"women",
")",
"or",
"tamoxifen",
"alone",
"(",
"383",
"women",
")",
".",
"The",
"median",
"follow",
"-",
"up",
"was",
"5.6",
"years",
".",
"The",
"rate",
"of",
"local",
"relapse",
"at",
"five",
"years",
"was",
"7.7",
"percent",
"in",
"the",
"tamoxifen",
"group",
"and",
"0.6",
"percent",
"in",
"the",
"group",
"given",
"tamoxifen",
"plus",
"irradiation",
"(",
"hazard",
"ratio",
",",
"8.3",
";",
"95",
"percent",
"confidence",
"interval",
",",
"3.3",
"to",
"21.2",
";",
"P",
"<",
"0.001",
")",
",",
"with",
"corresponding",
"five",
"-",
"year",
"disease",
"-",
"free",
"survival",
"rates",
"of",
"84",
"percent",
"and",
"91",
"percent",
"(",
"P=",
"0.004",
")",
".",
"A",
"planned",
"subgroup",
"analysis",
"of",
"611",
"women",
"with",
"T",
"1",
",",
"receptor",
"-",
"positive",
"tumors",
"indicated",
"a",
"benefit",
"from",
"radiotherapy",
"(",
"five",
"-",
"year",
"rates",
"of",
"local",
"relapse",
",",
"0.4",
"percent",
"with",
"tamoxifen",
"plus",
"radiotherapy",
"and",
"5.9",
"percent",
"with",
"tamoxifen",
"alone",
";",
"P",
"<",
"0.001",
")",
".",
"Overall",
",",
"there",
"was",
"a",
"significant",
"difference",
"in",
"the",
"rate",
"of",
"axillary",
"relapse",
"at",
"five",
"years",
"(",
"2.5",
"percent",
"in",
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"tamoxifen",
"group",
"and",
"0.5",
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"group",
"given",
"tamoxifen",
"plus",
"irradiation",
",",
"P=",
"0.049",
")",
",",
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408 | [
"Protective",
"effects",
"of",
"nebivolol",
"against",
"anthracycline",
"-",
"induced",
"cardiomyopathy",
":",
"a",
"randomized",
"control",
"study",
".",
"We",
"aimed",
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"the",
"effect",
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"prophylactic",
"nebivolol",
"use",
"on",
"prevention",
"of",
"antracycline",
"-",
"induced",
"cardiotoxicity",
"in",
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"cancer",
"patients",
".",
"In",
"this",
"small",
",",
"prospective",
",",
"double",
"-",
"blind",
"study",
",",
"we",
"randomly",
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"45",
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"patients",
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"breast",
"cancer",
"and",
"planned",
"chemotheraphy",
"to",
"receive",
"nebivolol",
"5",
"mg",
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"(",
"n=",
"27",
")",
"or",
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"(",
"n=",
"18",
")",
".",
"Echocardiographic",
"measurements",
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"N",
"-",
"terminal",
"pro",
"-",
"brain",
"natriuretic",
"peptide",
"(",
"NT",
"-",
"pro",
"-",
"BNP",
")",
"levels",
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"at",
"6",
"-month",
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".",
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"NT",
"-",
"pro",
"-",
"BNP",
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",",
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"(",
"LV",
")",
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"-",
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"-",
"diastolic",
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"(",
"LVESD",
":",
"29.7",
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"3.4",
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"33.4",
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"4.5",
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";",
"LVEDD",
":",
"47.2",
"±",
"3.8",
"to",
"52.0",
"±",
"4.6",
"mm",
",",
"p=",
"0.01",
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"(",
"LVESD",
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"30.4",
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"3.5",
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"31.0",
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"3.6",
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",",
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"0.20",
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"LVEDD",
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"47.0",
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"4.4",
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",",
"p=",
"0.93",
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",",
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"p=",
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"-",
"induced",
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409 | [
"Phase",
"III",
"trial",
"of",
"epirubicin",
"plus",
"paclitaxel",
"compared",
"with",
"epirubicin",
"plus",
"cyclophosphamide",
"as",
"first",
"-",
"line",
"chemotherapy",
"for",
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"breast",
"cancer",
":",
"United",
"Kingdom",
"National",
"Cancer",
"Research",
"Institute",
"trial",
"AB",
"01",
".",
"To",
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"the",
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"and",
"tolerability",
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"and",
"paclitaxel",
"(",
"EP",
")",
"with",
"epirubicin",
"and",
"cyclophosphamide",
"(",
"EC",
")",
"as",
"first",
"-",
"line",
"chemotherapy",
"for",
"metastatic",
"breast",
"cancer",
"(",
"MBC",
")",
".",
"Patients",
"previously",
"untreated",
"with",
"chemotherapy",
"(",
"except",
"for",
"adjuvant",
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")",
"were",
"randomly",
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"either",
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"(",
"epirubicin",
"75",
"mg",
"/",
"m",
"2",
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"paclitaxel",
"200",
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"/",
"m",
"2",
")",
"or",
"EC",
"(",
"epirubicin",
"75",
"mg",
"/",
"m",
"2",
"and",
"cyclophosphamide",
"600",
"mg",
"/",
"m",
"2",
")",
"administered",
"intravenously",
"every",
"3",
"weeks",
"for",
"a",
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"six",
"cycles",
".",
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"primary",
"outcome",
"was",
"progression",
"-",
"free",
"survival",
";",
"secondary",
"outcome",
"measures",
"were",
"overall",
"survival",
",",
"response",
"rates",
",",
"and",
"toxicity",
".",
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"1996",
"and",
"1999",
",",
"705",
"patients",
"(",
"353",
"EP",
"patients",
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"352",
"EC",
"patients",
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"underwent",
"random",
"assignment",
".",
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"well",
"matched",
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"the",
"two",
"groups",
",",
"and",
"71",
"%",
"of",
"patients",
"received",
"six",
"cycles",
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".",
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"response",
"rates",
"were",
"65",
"%",
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"EP",
"group",
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"55",
"%",
"for",
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"EC",
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"P",
"=",
".",
"015",
")",
".",
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"analysis",
",",
"641",
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"(",
"91",
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")",
"had",
"died",
".",
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"progression",
"-",
"free",
"survival",
"time",
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"7.0",
"months",
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"EP",
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"and",
"7.1",
"months",
"for",
"the",
"EC",
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"(",
"hazard",
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"=",
"1.07",
";",
"95",
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",",
"0.92",
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"1.24",
";",
"P",
"=",
".",
"41",
")",
",",
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"median",
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"survival",
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"months",
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"14",
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"1.02",
";",
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"0.87",
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"line",
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"-",
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410 | [
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".",
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"retrospectively",
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"lower",
"axillary",
"lymph",
"node",
"dissection",
"caudal",
"to",
"the",
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",",
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"88.4",
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"(",
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",",
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"N",
"(",
"0",
")",
"breast",
"cancer",
"."
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411 | [
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"/",
"cyclophosphamide",
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"ixabepilone",
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"paclitaxel",
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"early",
"stage",
"breast",
"cancer",
"and",
"evaluation",
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"βIII",
"-",
"tubulin",
"expression",
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"a",
"predictive",
"marker",
".",
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"randomized",
"phase",
"II",
"trial",
"was",
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"to",
"compare",
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"rate",
"of",
"pathologic",
"complete",
"response",
"(",
"pCR",
")",
"induced",
"by",
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"cyclophosphamide",
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"(",
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"paclitaxel",
"in",
"women",
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"early",
"stage",
"breast",
"cancer",
"(",
"BC",
")",
".",
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"of",
"βIII",
"-",
"tubulin",
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"a",
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".",
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",",
"histologically",
"confirmed",
"primary",
"invasive",
"breast",
"adenocarcinoma",
"received",
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"cycles",
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"AC",
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"1",
":1",
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"40",
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"/",
"m",
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"3",
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"(",
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"148",
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"80",
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"/",
"m",
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"1",
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"(",
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"147",
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"needle",
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"-",
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"18.6",
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"30.8",
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"19.4",
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"31.7",
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"4",
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412 | [
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"-",
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421 | [
"Lanreotide",
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"prevention",
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"node",
"dissection",
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"cancer",
":",
"a",
"phase",
"III",
"double",
"blind",
",",
"randomized",
",",
"placebo",
"-",
"controlled",
"trial",
".",
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"of",
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"Autogel",
"90",
"mg",
"PR",
"to",
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"lymphorrhea",
"after",
"axillary",
"dissection",
"in",
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"cancer",
".",
"A",
"Phase",
"III",
"double",
"-",
"blind",
",",
"randomized",
",",
"placebo",
"-",
"controlled",
"trial",
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"1",
"st",
",",
"2008",
",",
"and",
"December",
"31",
"st",
",",
"2010",
".",
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"primary",
"endpoint",
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"the",
"lymphorrhea",
"volume",
"(",
"ml",
")",
"in",
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"axillary",
"drain",
"during",
"the",
"first",
"four",
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"days",
".",
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"end",
"points",
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"days",
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"axillary",
"drain",
"removal",
",",
"hospital",
"stay",
"duration",
"(",
"days",
")",
",",
"lymphorrhea",
"volume",
"(",
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")",
"up",
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"15",
",",
"30",
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"180",
",",
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"aspiration",
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"number",
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"aspirations",
",",
"evaluation",
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",",
"arm",
"pain",
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"15",
",",
"30",
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"180",
".",
"A",
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"148",
"patients",
"were",
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"the",
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".",
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"145",
"patients",
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"randomized",
"and",
"analysed",
"on",
"an",
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"-",
"to",
"-",
"treat",
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".",
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"73",
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"72",
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"lanreotide",
".",
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",",
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",",
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",",
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",",
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"did",
"not",
"identify",
"any",
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"significant",
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"lymphorrhea",
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422 | [
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",",
"phase",
"II",
",",
"placebo",
"-",
"controlled",
",",
"trial",
"of",
"fulvestrant",
"plus",
"vandetanib",
"in",
"postmenopausal",
"women",
"with",
"bone",
"only",
"or",
"bone",
"predominant",
",",
"hormone",
"-",
"receptor",
"-",
"positive",
"metastatic",
"breast",
"cancer",
"(",
"MBC",
")",
":",
"the",
"OCOG",
"ZAMBONEY",
"study",
".",
"Biomarkers",
"of",
"bone",
"turnover",
",",
"including",
"urine",
"N",
"-",
"telopeptide",
"(",
"uNTx",
")",
",",
"have",
"been",
"used",
"as",
"surrogate",
"measures",
"of",
"response",
"to",
"bone",
"-",
"targeted",
"therapies",
".",
"Vascular",
"endothelial",
"growth",
"factor",
"(",
"VEGF",
")",
"levels",
"correlate",
"with",
"extent",
"of",
"bone",
"metastases",
".",
"We",
"assessed",
"whether",
"vandetanib",
",",
"an",
"inhibitor",
"of",
"VEGF",
",",
"epidermal",
"growth",
"factor",
"receptor",
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"RET",
"signalling",
",",
"improved",
"uNTx",
"response",
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"added",
"to",
"fulvestrant",
"(",
"F",
")",
"in",
"breast",
"cancer",
"patients",
"with",
"bone",
"metastases",
".",
"Postmenopausal",
"patients",
"with",
"bone",
"predominant",
",",
"hormone",
"-",
"receptor",
"-",
"positive",
"metastatic",
"breast",
"cancer",
"were",
"randomised",
"to",
"F",
"(",
"500",
"mg",
"IM",
"days",
"1",
",",
"15",
",",
"29",
",",
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")",
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"(",
"100",
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"PO",
"OD",
")",
"(",
"FV",
")",
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"placebo",
"(",
"FP",
")",
".",
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"uNTx",
"response",
".",
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"PFS",
",",
"OS",
",",
"RECIST",
"response",
",",
"pain",
"scores",
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"toxicity",
".",
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"-",
"one",
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"FV",
"and",
"68",
"to",
"FP",
".",
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"127",
"analyzable",
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",",
"an",
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"response",
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"66",
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"FV",
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"54",
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"FP",
"(",
"p",
"=",
"0.21",
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".",
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"groups",
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"PFS",
";",
"HR",
"=",
"0.95",
"(",
"95",
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"0.65",
"-",
"1.38",
")",
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"OS",
"HR",
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"0.69",
"(",
"95",
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"-",
"1.31",
")",
".",
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"62",
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"measurable",
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",",
"clinical",
"benefit",
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"41",
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"43",
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",",
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"(",
"p",
"=",
"0.47",
")",
".",
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"adverse",
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",",
"3.3",
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"for",
"FV",
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"5.9",
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"(",
">",
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"/",
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"2.32",
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"4.33",
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".",
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"vandetanib",
"to",
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"not",
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"biomarker",
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"PFS",
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"OS",
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"patients",
"with",
"bone",
"metastases",
".",
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423 | [
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"+",
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"+",
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"(",
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"in",
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"on",
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"trastuzumab",
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".",
"A",
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426 | [
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"-",
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"[",
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",",
"clinical",
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"MUC",
"1",
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".",
"Herein",
",",
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"-",
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",",
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",",
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"bands",
"combined",
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"music",
"/",
"instructions",
"on",
"patients",
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"at",
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"-",
"induced",
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"-",
"induced",
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"(",
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")",
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"cancer",
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",",
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"their",
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"accounted",
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"'",
"expectations",
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",",
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",",
"a",
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".",
"The",
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"of",
"acupressure",
"bands",
"could",
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"enhanced",
"by",
"boosting",
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"'",
"expectation",
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"'",
"efficacy",
".",
"Two",
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"forty",
"-",
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"-",
"naïve",
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"breast",
"cancer",
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"control",
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428 | [
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"cancer",
"prevention",
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"health",
"advisors",
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"Caribbean",
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"health",
"promoting",
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",",
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"serve",
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"-",
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",",
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",",
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",",
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",",
"10",
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"messages",
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"3.3",
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"-",
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"95",
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"-",
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"-",
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"-",
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"-",
"HER",
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"option",
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440 | [
"Joint",
"Estimation",
"of",
"Cardiac",
"Toxicity",
"and",
"Recurrence",
"Risks",
"After",
"Comprehensive",
"Nodal",
"Photon",
"Versus",
"Proton",
"Therapy",
"for",
"Breast",
"Cancer",
".",
"The",
"study",
"aims",
"to",
"perform",
"joint",
"estimation",
"of",
"the",
"risk",
"of",
"recurrence",
"caused",
"by",
"inadequate",
"radiation",
"dose",
"coverage",
"of",
"lymph",
"node",
"targets",
"and",
"the",
"risk",
"of",
"cardiac",
"toxicity",
"caused",
"by",
"radiation",
"exposure",
"to",
"the",
"heart",
".",
"Delivered",
"photon",
"plans",
"are",
"compared",
"with",
"realistic",
"proton",
"plans",
",",
"thereby",
"providing",
"evidence",
"-",
"based",
"estimates",
"of",
"the",
"heterogeneity",
"of",
"treatment",
"effects",
"in",
"consecutive",
"cases",
"for",
"the",
"2",
"radiation",
"treatment",
"modalities",
".",
"Forty",
"-",
"one",
"patients",
"referred",
"for",
"postlumpectomy",
"comprehensive",
"nodal",
"photon",
"irradiation",
"for",
"left",
"-",
"sided",
"breast",
"cancer",
"were",
"included",
".",
"Comparative",
"proton",
"plans",
"were",
"optimized",
"by",
"a",
"spot",
"scanning",
"technique",
"with",
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"-",
"field",
"optimization",
"from",
"2",
"en",
"face",
"beams",
".",
"Cardiotoxicity",
"risk",
"was",
"estimated",
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"the",
"model",
"of",
"Darby",
"et",
"al",
",",
"and",
"risk",
"of",
"recurrence",
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"a",
"compromise",
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"lymph",
"node",
"coverage",
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"estimated",
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"a",
"linear",
"dose",
"-",
"response",
"model",
"fitted",
"to",
"the",
"recurrence",
"data",
"from",
"the",
"recently",
"published",
"EORTC",
"(",
"European",
"Organisation",
"for",
"Research",
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")",
"22922",
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"10925",
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"NCIC",
"-",
"CTG",
"(",
"National",
"Cancer",
"Institute",
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"Canada",
"Clinical",
"Trials",
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")",
"MA",
".",
"20",
"randomized",
"controlled",
"trials",
".",
"Excess",
"absolute",
"risk",
"of",
"cardiac",
"morbidity",
"was",
"small",
"with",
"photon",
"therapy",
"at",
"an",
"attained",
"age",
"of",
"80",
"years",
",",
"with",
"median",
"values",
"of",
"1.0",
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"(",
"range",
",",
"0.2",
"%",
"-",
"2.9",
"%",
")",
"and",
"0.5",
"%",
"(",
"range",
",",
"0.03",
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"-",
"1.0",
"%",
")",
"with",
"and",
"without",
"cardiac",
"risk",
"factors",
",",
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",",
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"lower",
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"proton",
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"(",
"0.13",
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",",
"0.02",
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"-",
"0.5",
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"]",
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"0.06",
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"[",
"range",
",",
"0.004",
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"0.3",
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"]",
",",
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".",
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"excess",
"absolute",
"risk",
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"cancer",
"recurrence",
"after",
"10",
"years",
"was",
"0.10",
"%",
"(",
"range",
",",
"0.0",
"%",
"-",
"0.9",
"%",
")",
"with",
"photons",
"and",
"0.02",
"%",
"(",
"range",
",",
"0.0",
"%",
"-",
"0.07",
"%",
")",
"with",
"protons",
".",
"The",
"association",
"between",
"age",
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"the",
"patient",
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"benefit",
"from",
"proton",
"therapy",
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"weak",
",",
"almost",
"non",
"-",
"existing",
"(",
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"rank",
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"-",
"0.15",
"and",
"-",
"0.30",
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"without",
"cardiac",
"risk",
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",",
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")",
".",
"Modern",
"photon",
"therapy",
"yields",
"limited",
"risk",
"of",
"cardiac",
"toxicity",
"in",
"most",
"patients",
",",
"but",
"proton",
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"reduce",
"the",
"predicted",
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"toxicity",
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"up",
"to",
"2.9",
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"the",
"risk",
"of",
"breast",
"cancer",
"recurrence",
"by",
"0.9",
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"in",
"individual",
"patients",
".",
"Predicted",
"benefit",
"correlates",
"weakly",
"with",
"age",
".",
"Combined",
"assessment",
"of",
"the",
"risk",
"from",
"cardiac",
"exposure",
"and",
"inadequate",
"target",
"coverage",
"is",
"desirable",
"for",
"rational",
"consideration",
"of",
"competing",
"photon",
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"proton",
"therapy",
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"."
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441 | [
"Long",
"-",
"term",
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"of",
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"versus",
"High",
"Durations",
"of",
"Aerobic",
"Exercise",
"on",
"Biomarkers",
"of",
"Breast",
"Cancer",
"Risk",
":",
"Follow",
"-",
"up",
"to",
"a",
"Randomized",
"Controlled",
"Trial",
".",
"The",
"optimal",
"lifestyle",
"for",
"breast",
"cancer",
"prevention",
"over",
"the",
"long",
"term",
"is",
"unclear",
".",
"We",
"aimed",
"to",
"determine",
"whether",
"or",
"not",
"the",
"amount",
"of",
"exercise",
"prescribed",
"in",
"a",
"year",
"-",
"long",
"exercise",
"intervention",
"influences",
"breast",
"cancer",
"biomarker",
"levels",
"1",
"year",
"later",
".",
"We",
"conducted",
"a",
"24",
"-month",
"follow",
"-",
"up",
"study",
"(",
"2012",
"-",
"2014",
")",
"to",
"the",
"Breast",
"Cancer",
"and",
"Exercise",
"Trial",
"in",
"Alberta",
"(",
"BETA",
")",
",",
"a",
"12",
"-month",
",",
"two",
"-",
"armed",
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"1",
":1",
")",
",",
"two",
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"center",
"randomized",
"controlled",
"trial",
"of",
"exercise",
"in",
"400",
"cancer",
"-",
"free",
",",
"postmenopausal",
"women",
".",
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"exercise",
"prescription",
"was",
"moderate",
"-",
"vigorous",
"aerobic",
"exercise",
",",
"5",
"days",
"/",
"week",
"(",
"3",
"days",
"/",
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"supervised",
")",
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"minutes",
"/",
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")",
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"60",
"minutes",
"/",
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")",
".",
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"were",
"asked",
"not",
"to",
"change",
"their",
"usual",
"diet",
".",
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"linear",
"mixed",
"models",
"to",
"compare",
"biomarker",
"concentrations",
"(",
"C",
"-",
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"protein",
",",
"insulin",
",",
"glucose",
",",
"HOMA",
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"IR",
",",
"estrone",
",",
"sex",
"hormone",
"binding",
"globulin",
",",
"total",
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",",
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"estradiol",
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"over",
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"0",
",",
"12",
",",
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",",
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"group",
"-",
"time",
"interactions",
".",
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"months",
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"no",
"intervention",
",",
"24",
"-month",
"fasting",
"blood",
"samples",
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"available",
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"84.0",
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"and",
"82.5",
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"and",
"HIGH",
"groups",
",",
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"(",
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"333",
"/",
"400",
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".",
"We",
"found",
"no",
"evidence",
"that",
"0",
"to",
"24",
"-",
"or",
"12",
"to",
"24",
"-month",
"biomarker",
"changes",
"differed",
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"randomized",
"groups",
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"HIGH",
":",
"MODERATE",
"ratio",
"of",
"mean",
"biomarker",
"change",
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"0.97",
"to",
"1.06",
",",
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"0.05",
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")",
".",
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"more",
"favorable",
"biomarker",
"profiles",
"among",
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"/",
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",",
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"women",
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"no",
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"on",
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"-",
"term",
"biomarkers",
".",
"Exercise",
"may",
"lead",
"to",
"larger",
"improvements",
"in",
"breast",
"cancer",
"biomarkers",
"after",
"intervention",
"among",
"women",
"who",
"also",
"experience",
"fat",
"loss",
"with",
"exercise",
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442 | [
"Consolidation",
"with",
"high",
"-",
"dose",
"combination",
"alkylating",
"agents",
"with",
"bone",
"marrow",
"transplantation",
"significantly",
"improves",
"disease",
"-",
"free",
"survival",
"in",
"hormone",
"-",
"insensitive",
"metastatic",
"breast",
"cancer",
"in",
"complete",
"remission",
"compared",
"with",
"intensive",
"standard",
"-",
"dose",
"chemotherapy",
"alone",
".",
"We",
"conducted",
"this",
"study",
"to",
"determine",
"event",
"-",
"free",
"and",
"overall",
"survival",
"among",
"women",
"with",
"hormone",
"-",
"insensitive",
"or",
"hormone",
"-",
"resistant",
"metastatic",
"breast",
"cancer",
"receiving",
"consolidation",
"with",
"high",
"-",
"dose",
"chemotherapy",
"(",
"HDC",
")",
"and",
"hematopoietic",
"support",
"versus",
"no",
"further",
"chemotherapy",
"after",
"intensive",
"induction",
"chemotherapy",
".",
"Eligible",
"patients",
"received",
"induction",
"doxorubicin",
",",
"5",
"-fluorouracil",
",",
"and",
"methotrexate",
"(",
"AFM",
")",
"for",
"2",
"to",
"4",
"cycles",
".",
"Women",
"in",
"complete",
"remission",
"were",
"randomized",
"to",
"immediate",
"HDC",
"with",
"cyclophosphamide",
",",
"cisplatin",
",",
"and",
"carmustine",
"followed",
"by",
"autologous",
"hematopoietic",
"support",
"or",
"to",
"no",
"further",
"therapy",
".",
"Patients",
"on",
"the",
"observation",
"arm",
"of",
"therapy",
"were",
"offered",
"salvage",
"HDC",
"at",
"the",
"time",
"of",
"relapse",
".",
"Partial",
"responders",
"to",
"AFM",
"were",
"offered",
"immediate",
"HDC",
".",
"A",
"total",
"of",
"425",
"patients",
"were",
"enrolled",
"onto",
"the",
"study",
".",
"The",
"median",
"event",
"-",
"free",
"survival",
"for",
"women",
"randomized",
"to",
"induction",
"therapy",
"alone",
"was",
"3.8",
"months",
",",
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"9.7",
"months",
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"who",
"completed",
"HDC",
"(",
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".",
"006",
")",
".",
"Of",
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"observation",
",",
"5",
"(",
"10",
"%",
")",
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"51",
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"free",
",",
"compared",
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"13",
"(",
"26",
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")",
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"49",
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"HDC",
"(",
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"=",
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"03",
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".",
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"HDC",
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",",
"overall",
"survival",
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"similar",
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"women",
"randomized",
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"immediate",
"HDC",
".",
"Follow",
"-",
"up",
"is",
"now",
"in",
"excess",
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"5",
"years",
".",
"The",
"5",
"-year",
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"-",
"free",
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"is",
"15",
"%",
"(",
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"%",
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"interval",
",",
"12",
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"-",
"18",
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")",
",",
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",",
"17",
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"25",
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"-",
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"/",
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"-",
"dose",
"chemotherapy",
"regimens",
"may",
"further",
"improve",
"survival",
"in",
"metastatic",
"breast",
"cancer",
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443 | [
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"efficacy",
"of",
"erector",
"spinae",
"plane",
"block",
"performed",
"with",
"different",
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"surgery",
":",
"ramdomized",
",",
"prospective",
",",
"double",
"blinded",
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".",
"Breast",
"cancer",
"surgery",
"is",
"one",
"of",
"the",
"most",
"common",
"surgeries",
"among",
"the",
"female",
"population",
".",
"Nearly",
"half",
"of",
"the",
"patients",
"suffer",
"chronic",
"pain",
"following",
"breast",
"cancer",
"surgery",
",",
"and",
"24",
"%",
"of",
"them",
"categorizing",
"their",
"pain",
"as",
"moderate",
"to",
"high",
".",
"In",
"this",
"study",
",",
"effects",
"of",
"ultrasound",
"-",
"guided",
"erector",
"spinae",
"plane",
"(",
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"block",
"performed",
"using",
"two",
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"on",
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"tramadol",
"consumption",
",",
"pain",
"scores",
",",
"and",
"intraoperative",
"fentanyl",
"requirements",
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"surgery",
"were",
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"This",
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"-",
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",",
"prospective",
",",
"and",
"randomized",
"study",
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"-",
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"-",
"II",
",",
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"modified",
"radical",
"mastectomy",
"surgery",
".",
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"were",
"randomly",
"allocated",
"into",
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".",
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"I",
",",
"ESP",
"block",
"was",
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"0.375",
"%",
"bupivacaine",
".",
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",",
"ESP",
"block",
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"0.25",
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".",
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"anesthesia",
"was",
"induced",
"in",
"both",
"groups",
"according",
"to",
"the",
"standard",
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".",
"When",
"the",
"pain",
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"was",
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"4",
",",
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".",
")",
"25",
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".",
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";",
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",",
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";",
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",",
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"24",
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",",
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"199.52",
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"32.78",
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"(",
"p",
"=",
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".",
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",",
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"points",
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"with",
"those",
"in",
"group",
"II",
".",
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"mean",
"intraoperative",
"fentanyl",
"requirement",
"was",
"similar",
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"the",
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"groups",
".",
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"ESP",
"block",
"performed",
"with",
"both",
"concentrations",
"of",
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"provided",
"effective",
"postoperative",
"analgesia",
",",
"the",
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"significantly",
"reduced",
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"tramadol",
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".",
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"with",
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"New",
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"12618001334291",
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"08",
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"08",
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"-",
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"cancer",
"-",
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"randomized",
"controlled",
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".",
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"-",
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"-",
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"(",
"MBCT",
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"-",
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"cancer",
".",
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"women",
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"care",
"system",
"perspective",
"and",
"included",
"data",
"on",
"health",
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"retrieved",
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"(",
"T",
"1",
")",
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"(",
"T",
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")",
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",",
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"-",
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"-",
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"-",
"carried",
"-",
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"1",
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"4",
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"-",
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445 | [
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"VEGF",
"pathway",
"genes",
"in",
"neoadjuvant",
"breast",
"cancer",
"patients",
"receiving",
"bevacizumab",
":",
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"the",
"randomized",
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".",
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"(",
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")",
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"cancer",
"(",
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"-",
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",",
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".",
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",",
"no",
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"these",
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".",
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",",
"we",
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"nucleotide",
"polymorphisms",
"(",
"SNPs",
")",
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"-",
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"neoadjuvant",
"treatment",
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".",
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"cancer",
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"like",
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"PR-",
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"HER",
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"90",
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"/",
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"(",
"2",
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"cyclophosphamide",
"600",
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"/",
"m",
"(",
"2",
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"D",
"(",
"docetaxel",
"100",
"mg",
"/",
"m",
"(",
"2",
")",
"×",
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";",
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"-",
"D",
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"docetaxel",
"75",
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"(",
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".",
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"(",
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"in",
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".",
"Ninety",
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"four",
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"(",
"46",
"EC",
"-",
"D",
",",
"48",
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"DCb",
")",
".",
"pCR",
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"(",
"35",
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"-",
"D",
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"14",
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"-",
"DCb",
"(",
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"=",
"0.61",
")",
".",
"pCR",
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"axilla",
"was",
"seen",
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"30",
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"patients",
"in",
"both",
"arms",
".",
"The",
"overall",
"clinical",
"response",
"rate",
"was",
"70",
"%",
"(",
"95",
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"CI",
"56",
"-",
"83",
")",
"in",
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"D",
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"77",
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"95",
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"CI",
"65",
"-",
"87",
")",
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"EC",
"-",
"DCb",
"arm",
".",
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"/",
"4",
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"arms",
".",
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"addition",
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"carboplatin",
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"conventional",
"chemotherapy",
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"-",
"D",
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"-",
"like",
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"cancer",
"patients",
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"not",
"improve",
"the",
"efficacy",
"probably",
"because",
"they",
"had",
"already",
"received",
"an",
"alkylating",
"agent",
".",
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"findings",
"should",
"be",
"taken",
"into",
"consideration",
"when",
"developing",
"new",
"agents",
"for",
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447 | [
"New",
"-",
"onset",
"breast",
"tenderness",
"after",
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"of",
"estrogen",
"plus",
"progestin",
"therapy",
"and",
"breast",
"cancer",
"risk",
".",
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"plus",
"progestin",
"therapy",
"increases",
"breast",
"cancer",
"incidence",
"and",
"breast",
"tenderness",
".",
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"tenderness",
"during",
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"plus",
"progestin",
"therapy",
"is",
"associated",
"with",
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"cancer",
"risk",
"is",
"uncertain",
".",
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"Estrogen",
"+",
"Progestin",
"Trial",
",",
"which",
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"postmenopausal",
"women",
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"conjugated",
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",",
"0.625",
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",",
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",",
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"(",
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"8506",
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",",
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"(",
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"8102",
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",",
"participants",
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"clinical",
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".",
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"-",
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"tenderness",
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"baseline",
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"at",
"12",
"months",
".",
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"incidence",
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"cancer",
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"record",
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"(",
"mean",
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"-",
"up",
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",",
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",",
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"experienced",
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"-",
"onset",
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"(",
"36.1",
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"001",
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",",
"breast",
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"-",
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"1.48",
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448 | [
"Impact",
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"428",
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"survivors",
"with",
"permanent",
"chemotherapy",
"-",
"induced",
"alopecia",
"(",
"PCIA",
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".",
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"double",
"-",
"blind",
",",
"randomized",
"controlled",
"trial",
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"Samsung",
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"Center",
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",",
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"cancer",
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"years",
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"lotion",
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"DT",
"023",
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"botanical",
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"under",
"development",
"containing",
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"blend",
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"ingredients",
":",
"citrus",
",",
"cocoa",
",",
"guarana",
",",
"and",
"onion",
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"asked",
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"self",
"-",
"apply",
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"study",
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"or",
"placebo",
"twice",
"per",
"day",
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"6",
"months",
".",
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"hair",
"density",
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"thickness",
"were",
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"using",
"a",
"noninvasive",
"bioengineering",
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",",
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"-",
"reported",
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"were",
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"6",
"months",
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"randomization",
".",
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"total",
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"35",
"patients",
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"randomized",
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"N",
"=",
"18",
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"or",
"placebo",
"(",
"N",
"=",
"17",
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".",
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"group",
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"older",
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"in",
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"52.1",
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"41.6",
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"0.001",
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"mean",
"hair",
"density",
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"126.8",
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",",
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"P",
"=",
"0.005",
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".",
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"corresponding",
"values",
"for",
"hair",
"thickness",
"were",
"49.9",
"(",
"12.7",
")",
"and",
"48.1",
"(",
"8.4",
")",
"μm",
",",
"respectively",
".",
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"6",
"months",
",",
"hair",
"density",
"had",
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"24.9",
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"in",
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"intervention",
"and",
"control",
"groups",
",",
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"(",
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"=",
"0.37",
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".",
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"values",
"for",
"hair",
"thickness",
"were",
"19.8",
"and",
"35.6",
"%",
",",
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"(",
"P",
"=",
"0.23",
")",
".",
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"findings",
"were",
"observed",
"after",
"age",
"adjustment",
".",
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"pilot",
"randomized",
"clinical",
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",",
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",",
"tolerability",
",",
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450 | [
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"27",
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"7",
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"-",
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"22",
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"29",
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".",
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"12",
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"37",
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453 | [
"Effect",
"of",
"once",
"-",
"weekly",
"epoetin",
"beta",
"on",
"survival",
"in",
"patients",
"with",
"metastatic",
"breast",
"cancer",
"receiving",
"anthracycline-",
"and/or",
"taxane",
"-",
"based",
"chemotherapy",
":",
"results",
"of",
"the",
"Breast",
"Cancer",
"-",
"Anemia",
"and",
"the",
"Value",
"of",
"Erythropoietin",
"(",
"BRAVE",
")",
"study",
".",
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"Breast",
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"-",
"Anemia",
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"the",
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"(",
"BRAVE",
")",
"study",
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"whether",
"epoetin",
"beta",
"would",
"improve",
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"in",
"patients",
"with",
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"breast",
"cancer",
"(",
"MBC",
")",
".",
"BRAVE",
"was",
"an",
"open",
"-",
"label",
",",
"randomized",
",",
"multicenter",
"study",
"in",
"patients",
"with",
"MBC",
"treated",
"with",
"anthracycline-",
"and/or",
"taxane",
"-",
"based",
"chemotherapy",
".",
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"(",
"hemoglobin",
"[",
"Hb",
"]",
"<",
"12.9",
"g",
"/",
"dL",
")",
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":1",
")",
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"epoetin",
"beta",
"30",
",",
"000",
"U",
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".",
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",",
"transfusion-",
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"-",
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",",
"62",
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"beta",
"therapy",
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"63",
"(",
"27",
"%",
")",
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"232",
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".",
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"survival",
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"1.07",
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"0.87",
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"1.33",
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"1.07",
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",",
"0.89",
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"1.30",
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"=",
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"/",
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"13.3",
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"change",
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"11.5",
"v",
"11.4",
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"/",
"dL",
")",
".",
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"more",
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"events",
"(",
"TEEs",
")",
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"(",
"13",
"%",
"v",
"6",
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";",
"P",
"=",
".",
"012",
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"no",
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"in",
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"4",
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"v",
"3",
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")",
".",
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"did",
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"significantly",
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"a",
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"baseline",
"Hb",
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".",
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",",
"this",
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",",
"however",
",",
"exclude",
"clinically",
"important",
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"with",
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454 | [
"Open",
"-",
"label",
"randomized",
"clinical",
"trial",
"of",
"standard",
"neoadjuvant",
"chemotherapy",
"with",
"paclitaxel",
"followed",
"by",
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"versus",
"the",
"combination",
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"and",
"everolimus",
"followed",
"by",
"FEC",
"in",
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"receptor",
"-",
"negative",
"breast",
"cancer†",
".",
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"-",
"induced",
"cytotoxicity",
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"cancer",
"cells",
"in",
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"and",
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"vivo",
"in",
"addition",
"to",
"demonstrating",
"a",
"direct",
"antiproliferative",
"activity",
".",
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"aim",
"to",
"determine",
"pharmacodynamics",
"changes",
"and",
"response",
"of",
"adding",
"everolimus",
"to",
"standard",
"neoadjuvant",
"chemotherapy",
"in",
"triple",
"-",
"negative",
"breast",
"cancer",
"(",
"TNBC",
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".",
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"II",
"study",
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"with",
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"TNBC",
"randomized",
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"T",
"-",
"FEC",
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"paclitaxel",
"80",
"mg",
"/",
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"2",
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"/",
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"2",
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"12",
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",",
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"PI",
"3",
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"AKT",
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",",
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"-",
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"/",
"4",
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".",
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"of",
"everolimus",
"to",
"paclitaxel",
"was",
"well",
"tolerated",
".",
"Everolimus",
"downregulated",
"mTOR",
"signaling",
"but",
"downregulation",
"of",
"mTOR",
"at",
"48",
"h",
"did",
"not",
"correlate",
"with",
"12",
"-week",
"RR",
"in",
"the",
"TR",
"-",
"FEC",
"group",
".",
"NCT",
"00499603",
"."
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455 | [
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"in",
"the",
"prevention",
"of",
"chemotherapy",
"-",
"induced",
"bone",
"loss",
"in",
"premenopausal",
"women",
"with",
"breast",
"cancer",
":",
"a",
"randomized",
"controlled",
"trial",
".",
"Mortality",
"from",
"breast",
"cancer",
"has",
"decreased",
"in",
"large",
"part",
"because",
"of",
"adjuvant",
"chemotherapy",
".",
"Sequelae",
"of",
"therapy",
"include",
"ovarian",
"failure",
"and",
"bone",
"loss",
",",
"loss",
"that",
"would",
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"these",
"patients",
"'",
"risk",
"of",
"fracture",
"with",
"aging",
".",
"In",
"this",
"study",
",",
"we",
"assessed",
"the",
"efficacy",
"of",
"pamidronate",
"in",
"preventing",
"such",
"loss",
".",
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"study",
"was",
"a",
"1",
"-yr",
"randomized",
",",
"double",
"-",
"blind",
",",
"placebo",
"-",
"controlled",
"trial",
"comparing",
"pamidronate",
"60",
"mg",
"iv",
"every",
"3",
"months",
"with",
"placebo",
"in",
"40",
"premenopausal",
"women",
"with",
"newly",
"diagnosed",
"breast",
"cancer",
".",
"Bone",
"mineral",
"density",
"(",
"BMD",
")",
"of",
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"spine",
"and",
"hip",
"and",
"remodeling",
"markers",
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"yr",
".",
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",",
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"change",
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"12",
"months",
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"lumbar",
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"(",
"P",
"=",
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",",
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"spine",
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"hip",
".",
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"prevented",
"bone",
"loss",
"at",
"the",
"spine",
"and",
"hip",
"and",
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456 | [
"Circulating",
"hormones",
"and",
"breast",
"cancer",
"risk",
"in",
"premenopausal",
"women",
":",
"a",
"randomized",
"trial",
"of",
"low",
"-",
"dose",
"tamoxifen",
"and",
"fenretinide",
".",
"Tamoxifen",
"and",
"fenretinide",
"have",
"been",
"extensively",
"studied",
"and",
"exhibit",
"breast",
"cancer",
"-",
"preventing",
"activity",
".",
"We",
"aimed",
"to",
"assess",
"their",
"effect",
"on",
"sex",
"hormones",
",",
"sex",
"hormone",
"binding",
"globulin",
"(",
"SHBG",
")",
"and",
"retinol",
",",
"and",
"their",
"association",
"with",
"mammographic",
"density",
"(",
"MD",
")",
"and",
"breast",
"cancer",
"events",
".",
"In",
"a",
"double",
"-",
"blind",
",",
"placebo",
"-",
"controlled",
"trial",
",",
"premenopausal",
"women",
"at",
"risk",
"for",
"breast",
"cancer",
"were",
"randomized",
"to",
"tamoxifen",
"5",
"mg",
"/",
"day",
",",
"fenretinide",
",",
"both",
"agents",
",",
"or",
"placebo",
"for",
"2",
"years",
".",
"We",
"measured",
"MD",
"and",
"circulating",
"concentrations",
"of",
"follicle",
"-",
"stimulating",
"hormone",
",",
"luteinizing",
"hormone",
"(",
"LH",
")",
",",
"estradiol",
",",
"progesterone",
",",
"testosterone",
",",
"androstenedione",
",",
"dehydro",
"-",
"epiandrosteronesulfate",
",",
"prolactin",
",",
"SHBG",
",",
"and",
"retinol",
"at",
"baseline",
"and",
"on",
"yearly",
"intervals",
".",
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"associations",
"with",
"breast",
"cancer",
"events",
"were",
"evaluated",
"through",
"competing",
"risk",
"and",
"Cox",
"regression",
"survival",
"models",
".",
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"-",
"dose",
"tamoxifen",
"markedly",
"and",
"enduringly",
"increased",
"SHBG",
",",
"whereas",
"the",
"increases",
"in",
"testosterone",
",",
"estradiol",
",",
"and",
"prolactin",
"and",
"reduction",
"in",
"LH",
"weakened",
"after",
"1",
"year",
".",
"Fenretinide",
"increased",
"testosterone",
"and",
"androstenedione",
"and",
"decreased",
"retinol",
".",
"MD",
"correlated",
"directly",
"with",
"SHBG",
"and",
"inversely",
"with",
"retinol",
".",
"After",
"a",
"median",
"follow",
"-",
"up",
"of",
"12",
"years",
",",
"the",
"10",
"-year",
"cumulative",
"incidence",
"of",
"breast",
"cancer",
"events",
"was",
"37",
"%",
"in",
"women",
"with",
"SHBG",
"≤",
"59.3",
"nmol",
"/",
"L",
",",
"22",
"%",
"in",
"women",
"with",
"SHBG",
"between",
"59.3",
"and",
"101",
"nmol",
"/",
"L",
",",
"and",
"19",
"%",
"in",
"women",
"with",
"SHBG",
">",
"101",
"nmol",
"/",
"L",
"(",
"P",
"=",
"0.018",
")",
".",
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"difference",
"among",
"SHBG",
"tertiles",
"remained",
"statistically",
"significant",
"at",
"multivariable",
"analysis",
":",
"HR",
"=",
"2.26",
"(",
"95",
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"CI",
"1.04",
",",
"4.89",
")",
"for",
"the",
"lowest",
"versus",
"the",
"highest",
"tertile",
".",
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"conclude",
"that",
"low",
"-",
"dose",
"tamoxifen",
"or",
"fenretinide",
"exhibits",
"favorable",
"hormonal",
"profiles",
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"agents",
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"their",
"administration",
"for",
"prevention",
"of",
"breast",
"cancer",
"in",
"premenopause",
".",
"Notably",
",",
"SHBG",
"levels",
"were",
"inversely",
"associated",
"with",
"breast",
"neoplastic",
"events",
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457 | [
"A",
"double",
"-",
"blind",
"placebo",
"-",
"controlled",
"study",
"to",
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"safety",
"and",
"gynaecological",
"symptoms",
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"-",
"a",
"substudy",
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"I",
"Breast",
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"effects",
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"preventive",
"setting",
"on",
"endometrium",
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".",
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"96",
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"were",
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"(",
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",",
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"45",
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"placebo",
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",",
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"51",
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",",
"double",
"-",
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",",
"clinically",
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"-",
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"-",
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"-",
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",",
"at",
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"5",
"years",
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"-",
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".",
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"(",
"44",
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"increased",
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"median",
"4.3",
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",",
"p=",
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",",
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"there",
"was",
"no",
"difference",
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"the",
"groups",
"at",
"one",
"year",
"after",
"the",
"treatment",
".",
"There",
"were",
"also",
"statistically",
"significantly",
"more",
"referrals",
"to",
"hospitals",
"due",
"to",
"gynaecological",
"findings",
"in",
"the",
"TAM",
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"3.15",
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"intervals",
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"1.12",
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"10.10",
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"differences",
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"hysterectomy",
"rates",
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"other",
"serious",
"adverse",
"event",
"rates",
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".",
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"-",
"serious",
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"the",
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"treatment",
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"routine",
"gynaecological",
"follow",
"-",
"up",
"can",
"not",
"be",
"recommended",
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458 | [
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"a",
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"-",
"based",
"weight",
"loss",
"intervention",
"in",
"postmenopausal",
"women",
"with",
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"cancer",
"receiving",
"letrozole",
":",
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"trial",
".",
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"associated",
"with",
"poor",
"outcomes",
"in",
"women",
"with",
"operable",
"breast",
"cancer",
".",
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"interventions",
"(",
"LIs",
")",
"that",
"help",
"women",
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"their",
"weight",
"may",
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".",
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"randomized",
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"comparing",
"mail",
"-",
"based",
"delivery",
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",",
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"-",
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",",
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"goals",
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"letrozole",
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"1",
"-",
"3",
"N",
"0",
"-",
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",",
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",",
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459 | [
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"[",
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"cancer",
":",
"a",
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"]",
".",
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"(",
"SJR",
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"breast",
"cancer",
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".",
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"38",
"patients",
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"postmenopausal",
"women",
"with",
"breast",
"cancer",
",",
"who",
"received",
"aromatase",
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"(",
"AIs",
")",
",",
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"(",
"21",
"cases",
")",
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"the",
"control",
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"(",
"17",
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")",
"by",
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"Tablet",
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"containing",
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"600",
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"D",
"3",
"125",
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")",
",",
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".",
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",",
"6",
"g",
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",",
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".",
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"(",
"BMD",
")",
"level",
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"months",
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".",
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"(",
"BALP",
")",
",",
"bone",
"gla",
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"(",
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")",
",",
"tartrate",
"-",
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"(",
"TRAP",
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",",
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"C",
"-",
"terminal",
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"(",
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"-",
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"(",
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"2",
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",",
"serum",
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"lumbar",
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461 | [
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",",
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",",
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"education",
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"-",
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",",
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"its",
"effects",
"on",
"recurrence",
"is",
"unclear",
".",
"Observational",
"studies",
"have",
"suggested",
"decreased",
"recurrence",
"rates",
"from",
"HRT",
".",
"The",
"few",
"clinical",
"trials",
"in",
"this",
"field",
"have",
"all",
"been",
"closed",
"preterm",
".",
"The",
"Stockholm",
"trial",
"was",
"started",
"in",
"1997",
"and",
"designed",
"to",
"minimise",
"the",
"dose",
"of",
"progestogen",
"in",
"the",
"HRT",
"arm",
".",
"Disease",
"-",
"free",
"women",
"with",
"a",
"history",
"of",
"breast",
"cancer",
"were",
"randomised",
"to",
"HRT",
"(",
"n=",
"188",
")",
"or",
"no",
"HRT",
"(",
"n=",
"190",
")",
".",
"The",
"trial",
"was",
"stopped",
"in",
"2003",
"when",
"another",
"Swedish",
"study",
"(",
"HABITS",
",",
"the",
"Hormonal",
"Replacement",
"After",
"Breast",
"Cancer",
"-",
"Is",
"it",
"Safe",
"?",
")",
"reported",
"increased",
"recurrence",
".",
"However",
"the",
"Stockholm",
"material",
"showed",
"no",
"excess",
"risk",
"after",
"4",
"years",
"of",
"follow",
"-",
"up",
".",
"A",
"long",
"term",
"follow",
"-",
"up",
"has",
"now",
"been",
"performed",
".",
"After",
"10.8",
"years",
"of",
"follow",
"-",
"up",
",",
"there",
"was",
"no",
"difference",
"in",
"new",
"breast",
"cancer",
"events",
":",
"60",
"in",
"the",
"HRT",
"group",
"versus",
"48",
"among",
"controls",
"(",
"hazard",
"ratio",
"(",
"HR",
")",
"=",
"1.3",
";",
"95",
"%",
"confidence",
"interval",
"(",
"CI",
")",
"=",
"0.9",
"-",
"1.9",
")",
".",
"Among",
"women",
"on",
"HRT",
",",
"11",
"had",
"local",
"recurrence",
"and",
"12",
"distant",
"metastases",
"versus",
"15",
"and",
"12",
"for",
"the",
"controls",
".",
"There",
"were",
"14",
"contra",
"-",
"lateral",
"breast",
"cancers",
"in",
"the",
"HRT",
"group",
"and",
"four",
"in",
"the",
"control",
"group",
"(",
"HR=",
"3.6",
";",
"95",
"%",
"CI=",
"1.2",
"-",
"10.9",
";",
"p=",
"0.013",
")",
".",
"No",
"differences",
"in",
"mortality",
"or",
"new",
"primary",
"malignancies",
"were",
"found",
".",
"The",
"number",
"of",
"new",
"events",
"did",
"not",
"differ",
"significantly",
"between",
"groups",
",",
"in",
"contrast",
"to",
"previous",
"reports",
".",
"The",
"increased",
"recurrence",
"in",
"HABITS",
"has",
"been",
"attributed",
"to",
"higher",
"progestogen",
"exposure",
".",
"As",
"both",
"trials",
"were",
"prematurely",
"closed",
",",
"data",
"do",
"not",
"allow",
"firm",
"conclusions",
".",
"Both",
"studies",
"found",
"no",
"increased",
"mortality",
"from",
"breast",
"cancer",
"or",
"other",
"causes",
"from",
"HRT",
".",
"Current",
"guidelines",
"typically",
"consider",
"HRT",
"contraindicated",
"in",
"breast",
"cancer",
"survivors",
".",
"Findings",
"suggest",
"that",
",",
"in",
"some",
"women",
"symptom",
"relief",
"may",
"outweigh",
"the",
"potential",
"risks",
"of",
"HRT",
"."
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467 | [
"[",
"Chinese",
"HER",
"2",
"positive",
"early",
"breast",
"cancer",
"trastuzumab",
"adjuvant",
"therapy",
":",
"preliminary",
"outcomes",
"]",
".",
"To",
"evaluate",
"the",
"efficacy",
"and",
"safety",
"of",
"1",
"-year",
"adjuvant",
"trastuzumab",
"(",
"herceptin",
")",
"versus",
"1",
"-year",
"non",
"-",
"trastuzumab",
"observation",
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"patients",
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"2",
"-",
"positive",
"early",
"breast",
"cancer",
"during",
"a",
"median",
"follow",
"-",
"up",
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"1",
"year",
".",
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"HERA",
"trial",
"was",
"an",
"international",
",",
"multicenter",
",",
"randomized",
",",
"open",
"-",
"label",
",",
"phase",
"III",
"trial",
"comparing",
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"with",
"trastuzumab",
"for",
"1",
"and",
"2",
"years",
"with",
"observation",
"after",
"standard",
"adjuvant",
"chemotherapy",
",",
"radiotherapy",
"or",
"both",
"in",
"patients",
"with",
"HER",
"2",
"-",
"positive",
"node",
"-",
"positive",
"or",
"high",
"-",
"risk",
"node",
"-",
"negative",
"early",
"breast",
"cancer",
".",
"The",
"primary",
"endpoint",
"was",
"disease",
"-",
"free",
"survival",
".",
"Secondary",
"end",
"points",
"included",
"recurrence",
"-",
"free",
"survival",
",",
"distant",
"disease",
"-",
"free",
"survival",
",",
"overall",
"survival",
"and",
"cardiac",
"safety",
".",
"The",
"first",
"planned",
"interim",
"analysis",
"comparing",
"the",
"efficacy",
"and",
"safety",
"of",
"treatment",
"with",
"trastuzumab",
"for",
"1",
"year",
"versus",
"observation",
"were",
"completed",
"in",
"April",
"2005",
".",
"Only",
"the",
"outcomes",
"of",
"recruited",
"Chinese",
"patients",
"were",
"reported",
".",
"A",
"total",
"of",
"122",
"Chinese",
"patients",
"from",
"8",
"participating",
"centers",
"were",
"included",
"for",
"planned",
"interim",
"analysis",
".",
"And",
"they",
"were",
"divided",
"into",
"trastuzumab",
"(",
"n",
"=",
"68",
")",
"and",
"observation",
"(",
"n",
"=",
"54",
")",
"groups",
".",
"Three",
"and",
"eight",
"disease",
"-",
"free",
"survival",
"events",
"were",
"observed",
"in",
"the",
"trastuzumab",
"and",
"observation",
"groups",
"respectively",
".",
"Two",
"-",
"year",
"disease",
"-",
"free",
"survival",
"rates",
"were",
"92.9",
"%",
"and",
"81.4",
"%",
"respectively",
"(",
"P",
"=",
"0.0489",
")",
";",
"2",
"-year",
"recurrence",
"-",
"free",
"survival",
"and",
"distant",
"disease",
"-",
"free",
"survivals",
"were",
"98.1",
"%",
"vs",
"81.4",
"%",
"(",
"P",
"=",
"0.0064",
")",
"and",
"98.1",
"%",
"vs",
"83.3",
"%",
"(",
"P",
"=",
"0.0117",
")",
"respectively",
".",
"Trastuzumab",
"was",
"generally",
"well",
"-",
"tolerated",
"with",
"a",
"decent",
"safety",
"profile",
".",
"Severe",
"cardiotoxicity",
"was",
"not",
"observed",
".",
"One",
"-",
"year",
"treatment",
"with",
"adjuvant",
"trastuzumab",
"improves",
"disease",
"-",
"free",
"survival",
",",
"recurrence",
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"free",
"survival",
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"disease",
"-",
"free",
"survival",
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"patients",
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"2",
"-",
"positive",
"early",
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468 | [
"Cosmetic",
"outcomes",
"following",
"wide",
"local",
"excision",
"of",
"impalpable",
"breast",
"cancer",
":",
"is",
"radioguided",
"occult",
"lesion",
"localization",
"using",
"iodine-",
"125",
"seeds",
"better",
"than",
"hookwire",
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"?",
"Hookwire",
"localization",
"(",
"HWL",
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"is",
"the",
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"standard",
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"(",
"ROLLIS",
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",",
"has",
"been",
"associated",
"with",
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"re",
"-",
"excision",
"rates",
".",
"This",
"paper",
"investigates",
"if",
"cosmetic",
"outcomes",
"differ",
"in",
"women",
"undergoing",
"breast",
"conserving",
"surgery",
"with",
"HWL",
"or",
"ROLLIS",
".",
"Women",
"who",
"had",
"ROLLIS",
"or",
"HWL",
"guided",
"excision",
"for",
"impalpable",
"breast",
"cancer",
"within",
"a",
"multicentre",
"randomized",
"controlled",
"trial",
"(",
"RCT",
")",
"(",
"ANZCTR",
"12613000655741",
")",
"were",
"recruited",
".",
"Exclusions",
"were",
"level",
"2",
"oncoplasty",
"and",
"mastectomy",
".",
"Cosmetic",
"outcome",
"was",
"calculated",
"using",
"BCCT",
".",
"core",
",",
"the",
"Hopwood",
"Body",
"Image",
"Scale",
"and",
"estimated",
"percentage",
"breast",
"volume",
"excised",
".",
"Chi",
"-",
"squared",
"analysis",
"was",
"used",
"to",
"determine",
"the",
"difference",
"between",
"the",
"intervention",
"groups",
".",
"Analysis",
"was",
"performed",
"for",
"123",
"participants",
"(",
"66",
"ROLLIS",
"and",
"57",
"HWL",
")",
".",
"The",
"cosmetic",
"outcome",
"determined",
"by",
"BCCT",
".",
"core",
"for",
"all",
"participants",
"was",
"good",
"with",
"no",
"significant",
"difference",
"between",
"the",
"ROLLIS",
"and",
"HWL",
"groups",
".",
"When",
"reviewing",
"the",
"number",
"of",
"patients",
"who",
"experienced",
"either",
"a",
"good",
"or",
"excellent",
"result",
",",
"there",
"was",
"a",
"significantly",
"higher",
"number",
"of",
"patients",
"in",
"the",
"ROLLIS",
"group",
"(",
"n",
"=",
"53",
",",
"82",
"%",
")",
"compared",
"to",
"the",
"HWL",
"group",
"(",
"n",
"=",
"42",
",",
"74",
"%",
",",
"P",
"=",
"0.02",
".",
"There",
"were",
"no",
"differences",
"in",
"Hopwood",
"Body",
"Image",
"Scale",
"or",
"estimated",
"percentage",
"breast",
"volume",
"excised",
"between",
"groups",
".",
"There",
"was",
"a",
"reduction",
"in",
"the",
"frequency",
"of",
"re",
"-",
"excision",
"in",
"the",
"ROLLIS",
"group",
"(",
"n",
"=",
"3",
",",
"4.5",
"%",
")",
"versus",
"HWL",
"group",
"(",
"n",
"=",
"8",
",",
"14",
"%",
")",
";",
"however",
",",
"this",
"was",
"not",
"significant",
"(",
"P",
"=",
"0.06",
")",
".",
"Pre",
"-",
"operative",
"localization",
"of",
"impalpable",
"breast",
"lesions",
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469 | [
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"-",
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",",
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"travel",
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")",
"or",
"the",
"matching",
"placebo",
"(",
"NCT",
"00409071",
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")",
".",
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")",
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".",
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"2005",
"to",
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",",
"431",
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":",
"214",
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"(",
"C",
")",
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"217",
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"P",
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".",
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",",
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".",
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"12.0",
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470 | [
"Fulvestrant",
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472 | [
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473 | [
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474 | [
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"To",
"evaluate",
"the",
"effect",
"of",
"nurse",
"case",
"management",
"on",
"the",
"treatment",
"of",
"older",
"women",
"with",
"breast",
"cancer",
".",
"Randomized",
"prospective",
"trial",
".",
"Sixty",
"surgeons",
"practicing",
"at",
"13",
"community",
"and",
"two",
"public",
"hospitals",
"in",
"southeast",
"Texas",
".",
"Three",
"hundred",
"thirty",
"-",
"five",
"women",
"(",
"166",
"control",
"and",
"169",
"intervention",
")",
"aged",
"65",
"and",
"older",
"newly",
"diagnosed",
"with",
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"cancer",
".",
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"seeing",
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"randomized",
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"group",
"received",
"the",
"services",
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"a",
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"case",
"manager",
"for",
"12",
"months",
"after",
"the",
"diagnosis",
"of",
"breast",
"cancer",
".",
"The",
"primary",
"outcome",
"was",
"the",
"type",
"and",
"use",
"of",
"cancer",
"-",
"specific",
"therapies",
"received",
"in",
"the",
"first",
"6",
"months",
"after",
"diagnosis",
".",
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"outcomes",
"were",
"patient",
"satisfaction",
"and",
"arm",
"function",
"on",
"the",
"affected",
"side",
"2",
"months",
"after",
"diagnosis",
".",
"More",
"women",
"in",
"the",
"intervention",
"group",
"received",
"breast",
"-",
"conserving",
"surgery",
"(",
"28.6",
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"18.7",
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";",
"P=",
".",
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"(",
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"19.0",
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".",
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".",
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"-",
"conserving",
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",",
"greater",
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"case",
"management",
"group",
"received",
"adjuvant",
"radiation",
"(",
"78.3",
"%",
"vs",
"44.8",
"%",
";",
"P=",
".",
"001",
")",
"and",
"axillary",
"dissection",
"(",
"71.4",
"%",
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"44.8",
"%",
";",
"P=",
".",
"057",
")",
".",
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"in",
"the",
"case",
"management",
"group",
"were",
"also",
"more",
"likely",
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"receive",
"more",
"breast",
"reconstruction",
"surgery",
"(",
"9.3",
"%",
"vs",
"2.6",
"%",
",",
"P=",
".",
"054",
")",
",",
"and",
"women",
"in",
"the",
"case",
"management",
"group",
"with",
"advanced",
"cancer",
"were",
"more",
"likely",
"to",
"receive",
"chemotherapy",
"(",
"72.7",
"%",
"vs",
"30.0",
"%",
",",
"P=",
".",
"057",
")",
".",
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"months",
"after",
"surgery",
",",
"higher",
"percentages",
"of",
"women",
"in",
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"case",
"manager",
"group",
"had",
"normal",
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"84",
"%",
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"P=",
".",
"037",
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"were",
"more",
"likely",
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"they",
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"a",
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"their",
"treatment",
"(",
"82.2",
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"69.9",
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",",
"P=",
".",
"020",
")",
".",
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"were",
"more",
"likely",
"to",
"benefit",
"from",
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"case",
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".",
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"case",
"management",
"results",
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"management",
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"women",
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478 | [
"Relative",
"validity",
"of",
"a",
"brief",
"Fat",
"and",
"Fibre",
"Behaviour",
"Questionnaire",
"in",
"a",
"population",
"of",
"overweight",
"and",
"obese",
"breast",
"cancer",
"survivors",
":",
"A",
"note",
"of",
"caution",
".",
"Dietary",
"intake",
"assessment",
"is",
"often",
"difficult",
"in",
"research",
"contexts",
"because",
"of",
"time",
"and",
"resource",
"constraints",
"and",
"participant",
"burden",
".",
"Valid",
",",
"reliable",
"and",
"brief",
"assessments",
"of",
"dietary",
"behaviour",
"are",
"needed",
".",
"Additionally",
",",
"examination",
"of",
"instrument",
"performance",
"in",
"a",
"variety",
"of",
"populations",
"is",
"needed",
".",
"This",
"study",
"assessed",
"relative",
"validity",
"and",
"responsiveness",
"to",
"change",
"of",
"the",
"Fat",
"and",
"Fibre",
"Behaviour",
"Questionnaire",
"(",
"FFBQ",
")",
"in",
"a",
"population",
"of",
"breast",
"cancer",
"survivors",
"compared",
"with",
"dietary",
"intake",
"measured",
"by",
"24",
"-hour",
"recalls",
".",
"Data",
"were",
"collected",
"at",
"baseline",
"and",
"six",
"months",
"after",
"baseline",
"of",
"a",
"six",
"-",
"month",
",",
"randomised",
"controlled",
"trial",
"that",
"evaluated",
"a",
"telephone",
"-",
"based",
"behavioural",
"weight",
"loss",
"intervention",
"(",
"n",
"=",
"45",
")",
"compared",
"to",
"usual",
"care",
"(",
"n",
"=",
"45",
")",
"among",
"overweight",
"and",
"obese",
"breast",
"cancer",
"survivors",
".",
"The",
"FFBQ",
"'s",
"total",
"index",
",",
"fat",
"index",
"and",
"fibre",
"index",
"were",
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"validity",
"against",
"two",
"24",
"-hour",
"recalls",
"(",
"Pearson",
"'s",
"correlations",
")",
".",
"Responsiveness",
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"change",
"was",
"assessed",
"as",
"intervention",
"group",
"change",
"divided",
"by",
"standard",
"deviation",
"of",
"usual",
"care",
"group",
"change",
".",
"Pearson",
"'s",
"correlations",
"of",
"the",
"fat",
"index",
"with",
"fat",
"intake",
"measures",
"ranged",
"from",
"-",
"0.09",
"to",
"-",
"0.30",
"(",
"P",
"<",
"0.05",
")",
"at",
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"and",
"from",
"-",
"0.19",
"to",
"-",
"0.28",
"(",
"P",
"<",
"0.05",
")",
"for",
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"change",
".",
"Correlations",
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"fibre",
"index",
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"energy",
"-",
"adjusted",
"fibre",
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"(",
"0.25",
"-",
"0.32",
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"24",
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"related",
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"-",
"related",
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"and",
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"related",
"dietary",
"changes",
"in",
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479 | [
"Multicenter",
"randomized",
"phase",
"III",
"study",
"of",
"the",
"cardioprotective",
"effect",
"of",
"dexrazoxane",
"(",
"Cardioxane",
")",
"in",
"advanced",
"/",
"metastatic",
"breast",
"cancer",
"patients",
"treated",
"with",
"anthracycline",
"-",
"based",
"chemotherapy",
".",
"Anthracycline",
"-",
"induced",
"cardiotoxicity",
"has",
"led",
"to",
"the",
"adoption",
"of",
"empirical",
"dose",
"limits",
"that",
"may",
"restrict",
"continued",
"use",
"of",
"anthracyclines",
"among",
"patients",
"who",
"might",
"benefit",
".",
"Dexrazoxane",
",",
"a",
"cardioprotective",
"agent",
",",
"has",
"been",
"shown",
"to",
"reduce",
"the",
"risk",
"of",
"anthracycline",
"-",
"associated",
"cardiotoxicity",
"when",
"given",
"from",
"first",
"dose",
"of",
"anthracycline",
".",
"This",
"study",
"sought",
"to",
"confirm",
"the",
"benefit",
"of",
"dexrazoxane",
"in",
"patients",
"at",
"high",
"risk",
"of",
"cardiotoxicity",
"due",
"to",
"prior",
"anthracycline",
"use",
".",
"A",
"total",
"of",
"164",
"female",
"breast",
"cancer",
"patients",
",",
"previously",
"treated",
"with",
"anthracyclines",
",",
"received",
"anthracycline",
"-",
"based",
"chemotherapy",
"either",
"with",
"(",
"n",
"=",
"85",
")",
"or",
"without",
"(",
"n",
"=",
"79",
")",
"dexrazoxane",
"for",
"a",
"maximum",
"of",
"six",
"cycles",
".",
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"with",
"those",
"receiving",
"anthracycline",
"alone",
",",
"patients",
"treated",
"with",
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"experienced",
"significantly",
"fewer",
"cardiac",
"events",
"(",
"39",
"%",
"versus",
"13",
"%",
",",
"P",
"<",
"0.001",
")",
"and",
"a",
"lower",
"and",
"less",
"severe",
"incidence",
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"heart",
"failure",
"(",
"11",
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"1",
"%",
",",
"P",
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".",
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"response",
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"was",
"unaffected",
"by",
"dexrazoxane",
"therapy",
".",
"The",
"frequency",
"of",
"adverse",
"events",
"was",
"similar",
"between",
"groups",
"and",
"there",
"were",
"no",
"significant",
"between",
"-",
"group",
"differences",
"in",
"the",
"number",
"of",
"dose",
"modifications",
"/",
"interruptions",
".",
"Dexrazoxane",
"significantly",
"reduced",
"the",
"occurrence",
"and",
"severity",
"of",
"anthracycline",
"-",
"induced",
"cardiotoxicity",
"in",
"patients",
"at",
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"risk",
"of",
"cardiac",
"dysfunction",
"due",
"to",
"previous",
"anthracycline",
"treatment",
"without",
"compromising",
"the",
"antitumor",
"efficacy",
"of",
"the",
"chemotherapeutic",
"regimen",
"."
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480 | [
"Topical",
"silver",
"sulfadiazine",
"for",
"the",
"prevention",
"of",
"acute",
"dermatitis",
"during",
"irradiation",
"for",
"breast",
"cancer",
".",
"This",
"study",
"aimed",
"to",
"evaluate",
"the",
"effectiveness",
"of",
"topical",
"silver",
"sulfadiazine",
"(",
"SSD",
")",
"in",
"preventing",
"acute",
"radiation",
"dermatitis",
"in",
"women",
"receiving",
"radiotherapy",
"for",
"breast",
"cancer",
".",
"A",
"randomized",
"controlled",
"clinical",
"trial",
"was",
"conducted",
"on",
"patients",
"with",
"breast",
"cancer",
"referred",
"for",
"radiotherapy",
"after",
"treatment",
"with",
"mastectomy",
"and",
"chemotherapy",
".",
"The",
"patients",
"were",
"randomized",
"into",
"the",
"intervention",
"(",
"n",
"=",
"51",
")",
"and",
"control",
"(",
"n",
"=",
"51",
")",
"groups",
"and",
"were",
"instructed",
"on",
"general",
"skin",
"care",
"during",
"radiotherapy",
".",
"The",
"intervention",
"group",
"received",
"SSD",
"cream",
"1",
"%",
",",
"three",
"times",
"a",
"day",
",",
"3",
"days",
"a",
"week",
",",
"for",
"5",
"weeks",
"during",
"radiotherapy",
"and",
"one",
"week",
"thereafter",
".",
"A",
"blinded",
"observer",
"assessed",
"the",
"severity",
"of",
"dermatitis",
"weekly",
"(",
"for",
"6",
"weeks",
")",
"and",
"graded",
"it",
"from",
"0",
"to",
"4",
"according",
"to",
"the",
"Radiation",
"Therapy",
"Oncology",
"Group",
"criteria",
".",
"The",
"two",
"groups",
"were",
"similar",
"in",
"baseline",
"characteristics",
".",
"Two",
"patients",
"in",
"the",
"control",
"group",
"discontinued",
"the",
"radiotherapy",
"course",
"because",
"of",
"severe",
"skin",
"injuries",
"(",
"grades",
"3",
"and",
"4",
")",
".",
"The",
"intervention",
"group",
"encountered",
"significantly",
"less",
"severe",
"dermatitis",
"during",
"radiotherapy",
"compared",
"to",
"the",
"controls",
".",
"The",
"total",
"score",
"of",
"skin",
"injury",
"was",
"also",
"lower",
"in",
"the",
"intervention",
"group",
"compared",
"with",
"controls",
"(",
"5.49",
"±",
"1.02",
"vs.",
"7.21",
"±",
"1.76",
",",
"p",
"<",
"0.001",
")",
".",
"A",
"multivariate",
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"found",
"that",
"the",
"use",
"of",
"SSD",
"cream",
"(",
"p",
"<",
"0.001",
")",
"and",
"flat",
"chest",
"wall",
"anatomy",
"(",
"p",
"=",
"0.008",
")",
"were",
"significantly",
"associated",
"with",
"a",
"decreased",
"skin",
"injury",
".",
"SSD",
"cream",
"reduced",
"the",
"severity",
"of",
"radiation",
"-",
"induced",
"skin",
"injury",
"compared",
"with",
"general",
"skin",
"care",
"alone",
".",
"Further",
"studies",
"in",
"patients",
"with",
"other",
"types",
"of",
"cancer",
"and",
"also",
"comparing",
"SSD",
"cream",
"with",
"other",
"topical",
"agents",
"are",
"warranted",
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481 | [
"SPECT",
"analysis",
"of",
"cardiac",
"perfusion",
"changes",
"after",
"whole",
"-",
"breast",
"/",
"chest",
"wall",
"radiation",
"therapy",
"with",
"or",
"without",
"active",
"breathing",
"coordinator",
":",
"results",
"of",
"a",
"randomized",
"phase",
"3",
"trial",
".",
"Cardiac",
"muscle",
"perfusion",
",",
"as",
"determined",
"by",
"single",
"-",
"photon",
"emission",
"computed",
"tomography",
"(",
"SPECT",
")",
",",
"decreases",
"after",
"breast",
"and/or",
"chest",
"wall",
"(",
"BCW",
")",
"irradiation",
".",
"The",
"active",
"breathing",
"coordinator",
"(",
"ABC",
")",
"enables",
"radiation",
"delivery",
"when",
"the",
"BCW",
"is",
"farther",
"from",
"the",
"heart",
",",
"thereby",
"decreasing",
"cardiac",
"exposure",
".",
"We",
"hypothesized",
"that",
"ABC",
"would",
"prevent",
"radiation",
"-",
"induced",
"cardiac",
"toxicity",
"and",
"conducted",
"a",
"randomized",
"controlled",
"trial",
"evaluating",
"myocardial",
"perfusion",
"changes",
"after",
"radiation",
"for",
"left",
"-",
"sided",
"breast",
"cancer",
"with",
"or",
"without",
"ABC",
".",
"Stages",
"I",
"to",
"III",
"left",
"breast",
"cancer",
"patients",
"requiring",
"adjuvant",
"radiation",
"therapy",
"(",
"XRT",
")",
"were",
"randomized",
"to",
"ABC",
"or",
"No",
"-",
"ABC",
".",
"Myocardial",
"perfusion",
"was",
"evaluated",
"by",
"SPECT",
"scans",
"(",
"before",
"and",
"6",
"months",
"after",
"BCW",
"radiation",
")",
"using",
"2",
"methods",
":",
"(",
"1",
")",
"fully",
"automated",
"quantitative",
"polar",
"mapping",
";",
"and",
"(",
"2",
")",
"semiquantitative",
"visual",
"assessment",
".",
"The",
"left",
"ventricle",
"was",
"divided",
"into",
"20",
"segments",
"for",
"the",
"polar",
"map",
"and",
"17",
"segments",
"for",
"the",
"visual",
"method",
".",
"Segments",
"were",
"grouped",
"by",
"anatomical",
"rings",
"(",
"apical",
",",
"mid",
",",
"basal",
")",
"or",
"by",
"coronary",
"artery",
"distribution",
".",
"For",
"the",
"visual",
"method",
",",
"2",
"nuclear",
"medicine",
"physicians",
",",
"blinded",
"to",
"treatment",
"groups",
",",
"scored",
"each",
"segment",
"'s",
"perfusion",
".",
"Scores",
"were",
"analyzed",
"with",
"nonparametric",
"tests",
"and",
"linear",
"regression",
".",
"Between",
"2006",
"and",
"2010",
",",
"57",
"patients",
"were",
"enrolled",
"and",
"43",
"were",
"available",
"for",
"analysis",
".",
"The",
"cohorts",
"were",
"well",
"matched",
".",
"The",
"apical",
"and",
"left",
"anterior",
"descending",
"coronary",
"artery",
"segments",
"had",
"significant",
"decreases",
"in",
"perfusion",
"on",
"SPECT",
"scans",
"in",
"both",
"ABC",
"and",
"No",
"-",
"ABC",
"cohorts",
".",
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"unadjusted",
"and",
"adjusted",
"analyses",
",",
"controlling",
"for",
"pretreatment",
"perfusion",
"score",
",",
"age",
",",
"and",
"chemotherapy",
",",
"ABC",
"was",
"not",
"significantly",
"associated",
"with",
"prevention",
"of",
"perfusion",
"deficits",
".",
"In",
"this",
"randomized",
"controlled",
"trial",
",",
"ABC",
"does",
"not",
"appear",
"to",
"prevent",
"radiation",
"-",
"induced",
"cardiac",
"perfusion",
"deficits",
"."
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482 | [
"Effect",
"of",
"weight",
"loss",
",",
"with",
"or",
"without",
"exercise",
",",
"on",
"body",
"composition",
"and",
"sex",
"hormones",
"in",
"postmenopausal",
"women",
":",
"the",
"SHAPE-",
"2",
"trial",
".",
"Physical",
"inactivity",
"and",
"overweight",
"are",
"risk",
"factors",
"for",
"postmenopausal",
"breast",
"cancer",
".",
"The",
"effect",
"of",
"physical",
"activity",
"may",
"be",
"partially",
"mediated",
"by",
"concordant",
"weight",
"loss",
".",
"We",
"studied",
"the",
"effect",
"on",
"serum",
"sex",
"hormones",
",",
"which",
"are",
"known",
"to",
"be",
"associated",
"with",
"postmenopausal",
"breast",
"cancer",
"risk",
",",
"that",
"is",
"attributable",
"to",
"exercise",
"by",
"comparing",
"randomly",
"obtained",
"equivalent",
"weight",
"loss",
"by",
"following",
"a",
"hypocaloric",
"diet",
"only",
"or",
"mainly",
"by",
"exercise",
".",
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",",
"insufficiently",
"active",
"women",
"were",
"randomised",
"to",
"a",
"diet",
"(",
"N",
"=",
"97",
")",
",",
"mainly",
"exercise",
"(",
"N",
"=",
"98",
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"or",
"control",
"group",
"(",
"N",
"=",
"48",
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".",
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"goal",
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"achieve",
"5",
"-",
"6",
"kg",
"of",
"weight",
"loss",
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"a",
"calorie",
"-",
"restricted",
"diet",
"or",
"an",
"intensive",
"exercise",
"programme",
"combined",
"with",
"only",
"a",
"small",
"caloric",
"restriction",
".",
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"outcomes",
"after",
"16",
"weeks",
"were",
"serum",
"sex",
"hormones",
"and",
"sex",
"hormone",
"-",
"binding",
"globulin",
"(",
"SHBG",
")",
".",
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"fat",
"and",
"lean",
"mass",
"were",
"measured",
"by",
"dual",
"-",
"energy",
"X",
"-",
"ray",
"absorptiometry",
".",
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"the",
"diet",
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"-",
"4.9",
"kg",
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"and",
"mainly",
"exercise",
"(",
"-",
"5.5",
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"achieved",
"the",
"target",
"weight",
"loss",
".",
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"exercise",
"versus",
"diet",
"(",
"difference",
"-",
"1.4",
"kg",
",",
"P",
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"0.001",
")",
".",
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"exercise",
"arm",
",",
"the",
"reduction",
"in",
"free",
"testosterone",
"was",
"statistically",
"significantly",
"greater",
"than",
"that",
"of",
"the",
"diet",
"arm",
"(",
"treatment",
"effect",
"ratio",
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"0.92",
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"0.043",
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",",
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"a",
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"for",
"androstenedione",
"(",
"TER",
"0.90",
",",
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"=",
"0.064",
")",
"and",
"SHBG",
"(",
"TER",
"1.05",
",",
"P",
"=",
"0.070",
")",
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"NCT",
"00127205",
"REGISTRATION",
"DATE",
":",
"July",
"2005",
"."
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489 | [
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"II",
"study",
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"nab",
"-",
"paclitaxel",
"as",
"first",
"-",
"line",
"chemotherapy",
"in",
"patients",
"with",
"HER",
"2",
"-",
"negative",
"metastatic",
"breast",
"cancer",
".",
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"administration",
"of",
"nanoparticle",
"albumin",
"-",
"bound",
"paclitaxel",
"(",
"nab",
"-",
"paclitaxel",
")",
"has",
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"a",
"safe",
"and",
"effective",
"treatment",
"for",
"metastatic",
"breast",
"cancer",
"(",
"MBC",
")",
"in",
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",",
"randomized",
",",
"open",
"-",
"label",
"phase",
"II",
"study",
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"safety",
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"nab",
"-",
"paclitaxel",
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"docetaxel",
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"patients",
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"epidermal",
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"receptor",
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"-",
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"-",
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"(",
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"/",
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",",
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"-",
"paclitaxel",
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"52.5",
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",",
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"-",
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"-",
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"follow",
"-",
"up",
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"3",
"years",
"of",
"oral",
"adjuvant",
"clodronate",
"therapy",
"shows",
"significant",
"prevention",
"of",
"osteoporosis",
"in",
"early",
"-",
"stage",
"breast",
"cancer",
".",
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"have",
"previously",
"reported",
"that",
"3",
"-year",
"adjuvant",
"clodronate",
"treatment",
"prevents",
"bone",
"loss",
"in",
"breast",
"cancer",
"patients",
".",
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"we",
"report",
"the",
"10",
"-year",
"follow",
"-",
"up",
"data",
"of",
"clodronate",
"in",
"the",
"prevention",
"of",
"treatment",
"-",
"related",
"osteoporosis",
"in",
"women",
"with",
"early",
"-",
"stage",
"breast",
"cancer",
".",
"Two",
"hundred",
"sixty",
"-",
"eight",
"pre-",
"and",
"postmenopausal",
",",
"node",
"-",
"positive",
"breast",
"cancer",
"patients",
"were",
"randomly",
"assigned",
"to",
"clodronate",
",",
"1.6",
"g",
"orally",
"administered",
"daily",
",",
"or",
"to",
"control",
"groups",
"for",
"3",
"years",
".",
"Premenopausal",
"women",
"were",
"treated",
"with",
"adjuvant",
"CMF",
"chemotherapy",
";",
"and",
"postmenopausal",
"women",
"were",
"treated",
"with",
"antiestrogens",
",",
"either",
"20",
"mg",
"tamoxifen",
"or",
"60",
"mg",
"toremifene",
",",
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"3",
"years",
".",
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"bone",
"mineral",
"density",
"(",
"BMD",
")",
"of",
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"lumbar",
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"hip",
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"1",
",",
"2",
",",
"3",
",",
"5",
",",
"and",
"10",
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"-",
"free",
"patients",
"were",
"included",
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"the",
"analyses",
"of",
"osteoporosis",
"-",
"free",
"survival",
".",
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"the",
"10",
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"period",
",",
"24",
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"were",
"diagnosed",
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".",
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"patients",
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"spinal",
"osteoporosis",
"(",
"three",
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"the",
"clodronate",
"group",
",",
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"11",
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"48",
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",",
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"14",
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",",
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"of",
"48",
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".",
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",",
"osteoporosis",
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"clodronate",
"group",
",",
"and",
"77.0",
"%",
"in",
"the",
"control",
"group",
"(",
"P",
"=",
".",
"035",
")",
".",
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"seen",
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"hip",
"osteoporosis",
"(",
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"v",
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"92",
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"therapy",
"significantly",
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"have",
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"osteopenia",
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491 | [
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"are",
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"bone",
"loss",
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"density",
"(",
"BMD",
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"in",
"women",
"treated",
"for",
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"breast",
"cancer",
".",
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"women",
"(",
"n",
"=",
"206",
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"age",
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"years",
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"markers",
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492 | [
"Nebivolol",
"effect",
"on",
"doxorubicin",
"-",
"induced",
"cardiotoxicity",
"in",
"breast",
"cancer",
".",
"The",
"aim",
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"this",
"study",
"was",
"to",
"assess",
"whether",
"nebivolol",
"treatment",
"could",
"have",
"beneficial",
"effects",
"in",
"the",
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"of",
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"-",
"induced",
"cardiotoxicity",
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"women",
",",
"mean",
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"52.6",
"±",
"13",
"years",
",",
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"negative",
"breast",
"cancer",
",",
"scheduled",
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".",
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":",
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"(",
"n=",
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")",
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"(",
"n=",
"30",
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".",
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"70",
"mg",
"/",
"m",
"2",
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"every",
"21",
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"/",
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".",
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",",
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"TDI",
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",",
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"(",
"STI",
")",
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"ventricular",
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",",
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"a",
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",",
"no",
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"LV",
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"diastolic",
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"were",
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".",
"The",
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"show",
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"benefit",
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"echocardiographic",
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"-",
"induced",
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"preliminary",
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",",
"larger",
"studies",
"with",
"a",
"longer",
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"-",
"up",
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493 | [
"Effects",
"of",
"a",
"Psychoeducational",
"Intervention",
"in",
"Patients",
"With",
"Breast",
"Cancer",
"Undergoing",
"Chemotherapy",
".",
"Compelling",
"evidence",
"has",
"yet",
"to",
"be",
"published",
"regarding",
"the",
"positive",
"effect",
"of",
"psychoeducational",
"interventions",
"(",
"PEIs",
")",
"on",
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"distress",
"in",
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"cancer",
".",
"The",
"impact",
"of",
"PEIs",
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"self",
"-",
"efficacy",
",",
"resilience",
",",
"and",
"quality",
"of",
"life",
"is",
"also",
"unclear",
".",
"The",
"aim",
"of",
"this",
"study",
"was",
"to",
"assess",
"the",
"effects",
"of",
"a",
"PEI",
"on",
"anxiety",
",",
"depression",
",",
"disease",
"-",
"specific",
"care",
"knowledge",
",",
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"-",
"efficacy",
",",
"resilience",
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"quality",
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"life",
"in",
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"with",
"breast",
"cancer",
"during",
"and",
"after",
"chemotherapy",
".",
"The",
"intervention",
"was",
"administered",
"before",
"and",
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"five",
"rounds",
"of",
"chemotherapy",
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".",
"A",
"randomized",
"controlled",
"trial",
"was",
"conducted",
".",
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"cancer",
"(",
"N",
"=",
"40",
")",
"were",
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"T",
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",",
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"session",
"(",
"T",
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")",
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"depression",
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"life",
"in",
"the",
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"group",
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"differences",
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"T",
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".",
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"differences",
"became",
"apparent",
"at",
"T",
"2",
"for",
"knowledge",
"and",
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"-",
"efficacy",
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494 | [
"Quality",
"of",
"life",
"among",
"women",
"diagnosed",
"with",
"breast",
"Cancer",
":",
"A",
"randomized",
"waitlist",
"controlled",
"trial",
"of",
"commercially",
"available",
"mobile",
"app",
"-",
"delivered",
"mindfulness",
"training",
".",
"The",
"primary",
"objective",
"was",
"to",
"evaluate",
"the",
"efficacy",
"of",
"commercially",
"available",
"mobile",
"app",
"-",
"delivered",
"mindfulness",
"training",
"(",
"AMT",
")",
",",
"compared",
"with",
"waitlist",
"control",
"(",
"WC",
")",
",",
"on",
"quality",
"of",
"life",
"(",
"QOL",
")",
"among",
"women",
"diagnosed",
"with",
"breast",
"cancer",
".",
"The",
"secondary",
"outcome",
"was",
"dispositional",
"mindfulness",
".",
"Enrollment",
",",
"app",
"utilization",
",",
"and",
"study",
"completion",
"are",
"reported",
"as",
"feasibility",
"objectives",
".",
"Women",
"diagnosed",
"with",
"breast",
"cancer",
"≤",
"5",
"years",
"(",
"n",
"=",
"112",
")",
"were",
"randomized",
"to",
"AMT",
"(",
"n",
"=",
"57",
")",
"or",
"WC",
"(",
"n",
"=",
"55",
")",
",",
"over",
"8",
"weeks",
",",
"with",
"4",
"weeks",
"of",
"follow",
"-",
"up",
".",
"We",
"conducted",
"linear",
"mixed",
"effects",
"models",
"to",
"examine",
"group",
"by",
"observation",
"interactions",
"on",
"QOL",
"and",
"dispositional",
"mindfulness",
"at",
"baseline",
",",
"during",
"intervention",
"(",
"5",
"-weeks",
")",
",",
"post",
"-",
"intervention",
"(",
"9",
"-weeks",
")",
",",
"and",
"follow",
"-",
"up",
"(",
"12",
"-weeks",
"post",
"-",
"baseline",
")",
".",
"Participants",
"assigned",
"to",
"AMT",
"reported",
"higher",
"QOL",
",",
"compared",
"with",
"those",
"assigned",
"to",
"WC",
",",
"from",
"baseline",
"through",
"follow",
"-",
"up",
"t",
"(",
"258.40",
")",
"=",
"3.09",
",",
"P",
"<",
"0.01",
",",
"95",
"%",
"CI",
"[",
"2.71",
",",
"11.90",
"]",
".",
"Participants",
"assigned",
"to",
"AMT",
"also",
"reported",
"higher",
"dispositional",
"mindfulness",
",",
"compared",
"with",
"those",
"assigned",
"to",
"WC",
",",
"from",
"baseline",
"through",
"follow",
"-",
"up",
"t",
"(",
"268.44",
")",
"=",
"2.04",
",",
"P",
"=",
"0.04",
",",
"95",
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"CI",
"[",
"0.01",
",",
"0.57",
"]",
".",
"App",
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"data",
"was",
"obtained",
"from",
"34",
"participants",
".",
"Fewer",
"participants",
"assigned",
"to",
"AMT",
"completed",
"all",
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"assessments",
",",
"compared",
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"participants",
"assigned",
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"WC",
",",
"(",
"χ",
"21",
"=",
"7.07",
",",
"P",
"=",
"0.008",
")",
".",
"Findings",
"suggest",
"commercially",
"available",
"AMT",
"may",
"proffer",
"some",
"benefit",
"to",
"women",
"seeking",
"to",
"enhance",
"their",
"QOL",
"following",
"breast",
"cancer",
"diagnosis",
"."
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495 | [
"Local",
"anesthetic",
"delivery",
"via",
"surgical",
"drain",
"provides",
"improved",
"pain",
"control",
"versus",
"direct",
"skin",
"infiltration",
"following",
"axillary",
"node",
"dissection",
"for",
"breast",
"cancer",
".",
"Axillary",
"node",
"dissection",
"has",
"a",
"central",
"role",
"in",
"the",
"surgical",
"management",
"of",
"breast",
"cancer",
";",
"however",
",",
"it",
"is",
"associated",
"with",
"a",
"significant",
"risk",
"of",
"lymphoedema",
"and",
"chronic",
"pain",
".",
"Peri",
"-",
"operative",
"administration",
"of",
"local",
"anesthesia",
"reduces",
"acute",
"and",
"persistent",
"post",
"-",
"surgical",
"pain",
",",
"but",
"there",
"is",
"currently",
"no",
"consensus",
"on",
"the",
"optimal",
"method",
"of",
"local",
"anesthetic",
"delivery",
".",
"Patients",
"undergoing",
"axillary",
"dissection",
"for",
"breast",
"cancer",
"were",
"randomly",
"assigned",
"to",
"receive",
"a",
"one",
"-",
"off",
"dose",
"of",
"levobupivacaine",
"0.5",
"%",
"(",
"up",
"to",
"2",
"mg",
"/",
"kg",
")",
"following",
"surgery",
",",
"either",
"via",
"the",
"surgical",
"drain",
"or",
"by",
"direct",
"skin",
"infiltration",
".",
"Post",
"-",
"operative",
"pain",
"control",
"at",
"rest",
"and",
"on",
"shoulder",
"abduction",
"was",
"assessed",
"using",
"a",
"numerical",
"rating",
"scale",
".",
"Total",
"analgesia",
"consumption",
"48",
"h",
"after",
"surgery",
"was",
"also",
"recorded",
".",
"Pain",
"scores",
"were",
"significantly",
"lower",
"when",
"local",
"anesthesia",
"was",
"administered",
"via",
"surgical",
"drain",
"at",
"both",
"3",
"and",
"12",
"h",
"after",
"surgery",
";",
"this",
"trend",
"extended",
"to",
"24",
"h",
"post",
"-",
"operatively",
".",
"However",
",",
"pain",
"scores",
"on",
"shoulder",
"abduction",
"did",
"not",
"differ",
"at",
"the",
"12",
"or",
"24",
"h",
"time",
"points",
".",
"No",
"differences",
"were",
"found",
"in",
"the",
"total",
"analgesia",
"consumption",
"or",
"length",
"of",
"hospital",
"stay",
"between",
"treatment",
"groups",
".",
"This",
"study",
"demonstrates",
"that",
"local",
"anesthetic",
"delivery",
"via",
"a",
"surgical",
"drain",
"provides",
"improved",
"pain",
"control",
"compared",
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"direct",
"skin",
"infiltration",
"following",
"axillary",
"node",
"dissection",
".",
"This",
"is",
"likely",
"to",
"be",
"important",
"for",
"the",
"management",
"of",
"acute",
"pain",
"in",
"the",
"immediate",
"post",
"-",
"operative",
"period",
";",
"however",
",",
"further",
"studies",
"may",
"be",
"required",
"to",
"validate",
"this",
"in",
"specific",
"patient",
"subgroups",
",",
"e.g.",
",",
"breast",
"-",
"conserving",
"surgery",
"versus",
"mastectomy",
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496 | [
"A",
"randomized",
"phase",
"III",
"study",
"evaluating",
"pegylated",
"liposomal",
"doxorubicin",
"versus",
"capecitabine",
"as",
"first",
"-",
"line",
"therapy",
"for",
"metastatic",
"breast",
"cancer",
":",
"results",
"of",
"the",
"PELICAN",
"study",
".",
"The",
"PELICAN",
"trial",
"evaluates",
"for",
"the",
"first",
"time",
"efficacy",
"and",
"safety",
"of",
"pegylated",
"liposomal",
"doxorubicin",
"(",
"PLD",
")",
"versus",
"capecitabine",
"as",
"first",
"-",
"line",
"treatment",
"of",
"metastatic",
"breast",
"cancer",
"(",
"MBC",
")",
".",
"This",
"randomized",
",",
"phase",
"III",
",",
"open",
"-",
"label",
",",
"multicenter",
"trial",
"enrolled",
"first",
"-",
"line",
"MBC",
"patients",
"who",
"were",
"ineligible",
"for",
"endocrine",
"or",
"trastuzumab",
"therapy",
".",
"Cumulative",
"adjuvant",
"anthracyclines",
"of",
"360",
"mg",
"/",
"m",
"2",
"doxorubicin",
"or",
"equivalent",
"were",
"allowed",
".",
"Left",
"ventricular",
"ejection",
"fraction",
"of",
">",
"50",
"%",
"was",
"required",
".",
"Patients",
"received",
"PLD",
"50",
"mg",
"/",
"m",
"2",
"every",
"28",
"days",
"or",
"capecitabine",
"1250",
"mg",
"/",
"m",
"2",
"twice",
"daily",
"for",
"14",
"days",
"every",
"21",
"days",
".",
"The",
"primary",
"endpoint",
"was",
"time",
"-",
"to",
"-",
"disease",
"progression",
"(",
"TTP",
")",
".",
"210",
"patients",
"were",
"randomized",
"(",
"n",
"=",
"105",
",",
"PLD",
"and",
"n",
"=",
"105",
",",
"capecitabine",
")",
".",
"Adjuvant",
"anthracyclines",
"were",
"given",
"to",
"37",
"%",
"(",
"PLD",
")",
"and",
"36",
"%",
"(",
"capecitabine",
")",
"of",
"patients",
".",
"No",
"significant",
"difference",
"was",
"observed",
"in",
"TTP",
"[",
"HR",
"=",
"1.21",
"(",
"95",
"%",
"confidence",
"interval",
",",
"0.838",
"-",
"1.750",
")",
"]",
".",
"Median",
"TTP",
"was",
"6.0",
"months",
"for",
"both",
"PLD",
"and",
"capecitabine",
".",
"Comparing",
"patients",
"with",
"or",
"without",
"prior",
"anthracyclines",
",",
"no",
"significant",
"difference",
"in",
"TTP",
"was",
"observed",
"in",
"the",
"PLD",
"arm",
"(",
"log",
"-",
"rank",
"P",
"=",
"0.64",
")",
".",
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"PLD",
"versus",
"capecitabine",
",",
"respectively",
",",
"overall",
"survival",
"(",
"median",
",",
"23.3",
"months",
"vs.",
"26.8",
"months",
")",
"and",
"time",
"-",
"to",
"-",
"treatment",
"failure",
"(",
"median",
",",
"4.6",
"months",
"vs.",
"3.7",
"months",
")",
"were",
"not",
"statistically",
"significantly",
"different",
".",
"Compared",
"to",
"PLD",
",",
"patients",
"on",
"capecitabine",
"experienced",
"more",
"serious",
"adverse",
"events",
"(",
"P",
"=",
"0.015",
")",
"and",
"more",
"cardiac",
"events",
"among",
"patients",
"who",
"had",
"prior",
"anthracycline",
"exposure",
"(",
"18",
"vs.",
"8",
"%",
";",
"P",
"=",
"0.31",
")",
".",
"Both",
"PLD",
"and",
"capecitabine",
"are",
"effective",
"first",
"-",
"line",
"agents",
"for",
"MBC",
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"cancer",
"prevention",
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".",
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",",
"impacting",
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",",
"the",
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".",
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"blind",
",",
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"-year",
"letrozole",
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"breast",
"cancer",
"incidence",
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"-",
"menopausal",
"BRCA",
"1",
"/",
"2",
"mutation",
"carriers",
"(",
"NCT",
"00673335",
")",
".",
"We",
"present",
"data",
"on",
"the",
"uptake",
"of",
"this",
"trial",
".",
"We",
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"characteristics",
"of",
"women",
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"the",
"LIBER",
"trial",
"(",
"n",
"=",
"113",
")",
"to",
"those",
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"in",
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"ongoing",
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"GENEPSO",
"cohort",
"(",
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"=",
"1",
",",
"505",
")",
".",
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"was",
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"survey",
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"to",
"all",
"active",
"centres",
",",
"with",
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"to",
"the",
"20",
"(",
"85",
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")",
"centres",
".",
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"the",
"women",
"enrolled",
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"the",
"GENEPSO",
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"the",
"survey",
",",
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"-",
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"1",
"/",
"2",
"mutation",
"carriers",
"were",
"eligible",
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"the",
"trial",
".",
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"hundred",
"and",
"thirty",
"-",
"four",
"women",
"eligible",
"from",
"chart",
"review",
"have",
"been",
"informed",
"by",
"mail",
"about",
"the",
"prevention",
"trial",
"and",
"were",
"invited",
"to",
"an",
"oral",
"information",
"by",
"participating",
"centres",
".",
"Forty",
"-",
"four",
"percentage",
"of",
"them",
"came",
"to",
"the",
"dedicated",
"medical",
"visit",
".",
"Uptake",
"of",
"drug",
"prevention",
"trial",
"was",
"32",
"%",
"among",
"women",
"informed",
"orally",
"and",
"15",
"%",
"of",
"all",
"the",
"eligible",
"women",
".",
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"reasons",
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"refusal",
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":",
"potential",
"side",
"effects",
",",
"probability",
"to",
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"the",
"placebo",
"and",
"lack",
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"support",
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"their",
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".",
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",",
"we",
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"prior",
"prophylactic",
"oophorectomy",
"and",
"previous",
"unilateral",
"breast",
"cancer",
"were",
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"women",
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"(",
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"60",
"%",
"and",
"50",
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"39",
"%",
",",
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")",
".",
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"15",
"%",
"uptake",
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"all",
"eligible",
"subjects",
",",
"greater",
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"1",
"/",
"2",
"mutation",
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"improve",
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".",
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"breast",
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"prophylactic",
"oophorectomy",
"are",
"more",
"likely",
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",",
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"breast",
"cancer",
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"-",
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"questionnaire",
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"cancer",
"risk",
"-",
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"an",
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"tablet",
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"A",
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