Datasets:

Stardrums

/

pico-breast-cancer

like 2

[ "EduCan", "trial", ":", "study", "protocol", "for", "a", "randomised", "controlled", "trial", "on", "the", "effectiveness", "of", "pain", "neuroscience", "education", "after", "breast", "cancer", "surgery", "on", "pain", ",", "physical", ",", "emotional", "and", "work", "-", "related", "functioning", ".", "Over", "the", "past", "decades", ",", "awareness", "on", "the", "importance", "of", "educational", "interventions", "in", "cancer", "pain", "management", "has", "increased", ".", "However", ",", "education", "is", "often", "restricted", "to", "biomedical", "pain", "management", "instructions", ".", "A", "more", "modern", "educational", "approach", ",", "also", "known", "as", "pain", "neuroscience", "education", "(", "PNE", ")", ",", "explains", "pain", "from", "a", "biopsychosocial", "perspective", ".", "We", "hypothesise", "that", "this", "more", "comprehensive", "educational", "approach", "in", "the", "early", "treatment", "phase", "of", "breast", "cancer", "will", "lead", "to", "more", "beneficial", "effects", "for", "cancer", "pain", "management", ".", "Therefore", ",", "the", "aim", "of", "the", "present", "study", "is", "to", "investigate", "the", "effectiveness", "of", "this", "PNE", "intervention", ",", "in", "addition", "to", "best", "evidence", "physical", "therapy", "modalities", "for", "treatment", "and", "prevention", "of", "pain", ",", "physical", ",", "emotional", "and", "work", "-", "related", "functioning", "after", "breast", "cancer", "surgery", ",", "compared", "with", "a", "traditional", "biomedical", "educational", "intervention", ".", "A", "double", "-", "blinded", "randomised", "controlled", "trial", "has", "been", "started", "in", "November", "2017", "at", "the", "University", "Hospitals", "of", "Leuven", ".", "Immediately", "after", "breast", "cancer", "surgery", ",", "all", "participants", "(", "n=", "184", ")", "receive", "a", "12", "-week", "intensive", "standard", "physical", "therapy", "programme", ".", "They", "receive", "three", "additional", "refresher", "sessions", "at", "6", ",", "8", "and", "12", "months", "postsurgery", ".", "In", "addition", ",", "participants", "receive", "three", "educational", "sessions", "during", "the", "first", "-", "month", "postsurgery", "and", "three", "'", "booster", "sessions", "'", "at", "6", ",", "8", "and", "12", "months", "postsurgery", ".", "In", "the", "intervention", "group", ",", "the", "content", "of", "the", "education", "sessions", "is", "based", "on", "the", "modern", "PNE", "approach", ".", "Whereas", "in", "the", "control", "group", ",", "the", "education", "is", "based", "on", "the", "traditional", "biomedical", "approach", ".", "The", "primary", "outcome", "parameter", "is", "pain", "-", "related", "disability", "1", "year", "after", "surgery", ".", "Secondary", "outcomes", "related", "to", "other", "dimensions", "of", "pain", ",", "physical", ",", "emotional", "and", "work", "-", "related", "functioning", "at", "1", "-week", ",", "4", ",", "6", ",", "8", ",", "12", "and", "18", "months", "postsurgery", ".", "The", "study", "will", "be", "conducted", "in", "accordance", "with", "the", "Declaration", "of", "Helsinki", ".", "This", "protocol", "has", "been", "approved", "by", "the", "ethical", "committee", "of", "the", "University", "Hospitals", "of", "Leuven", ".", "Results", "will", "be", "disseminated", "via", "peer", "-", "reviewed", "scientific", "journals", "and", "presentations", "at", "congresses", ".", "NCT", "03351075", "." ]

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[ "Prospective", "randomized", "trial", "of", "paravertebral", "block", "for", "patients", "undergoing", "breast", "cancer", "surgery", ".", "The", "goal", "of", "the", "current", "study", "was", "to", "evaluate", "the", "effect", "of", "regional", "anesthesia", "using", "paravertebral", "block", "(", "PVB", ")", "on", "postoperative", "pain", "after", "breast", "surgery", ".", "Patients", "undergoing", "unilateral", "breast", "surgery", "without", "reconstruction", "were", "randomized", "to", "general", "anesthesia", "(", "GA", ")", "only", "or", "PVB", "with", "GA", "and", "pain", "scores", "assessed", ".", "Eighty", "patients", "were", "randomized", "(", "41", "to", "GA", "and", "39", "to", "PVB", "with", "GA", ")", ".", "Operative", "times", "were", "not", "significantly", "different", "between", "groups", ".", "Pain", "scores", "were", "lower", "after", "PVB", "compared", "to", "GA", "at", "1", "hour", "(", "1", "vs", "3", ",", "P", "=", ".", "006", ")", "and", "3", "hours", "(", "0", "vs", "2", ",", "P", "=", ".", "001", ")", "but", "not", "at", "later", "time", "points", ".", "The", "overall", "worst", "pain", "experienced", "was", "lower", "with", "PVB", "(", "3", "vs", "5", ",", "P", "=", ".", "02", ")", ".", "More", "patients", "were", "pain", "-", "free", "in", "the", "PVB", "group", "at", "1", "hour", "(", "44", "%", "vs", "17", "%", ",", "P", "=", ".", "014", ")", "and", "3", "hours", "(", "54", "%", "vs", "17", "%", ",", "P", "=", ".", "005", ")", "postoperatively", ".", "PVB", "significantly", "decreases", "postoperative", "pain", "up", "to", "3", "hours", "after", "breast", "cancer", "surgery", "." ]

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[ "Weight", "Lifting", "and", "Physical", "Function", "Among", "Survivors", "of", "Breast", "Cancer", ":", "A", "Post", "Hoc", "Analysis", "of", "a", "Randomized", "Controlled", "Trial", ".", "Survivors", "of", "breast", "cancer", "may", "experience", "deterioration", "of", "physical", "function", ".", "This", "is", "important", "because", "poor", "physical", "function", "may", "be", "associated", "with", "premature", "mortality", ",", "injurious", "falls", ",", "bone", "fracture", ",", "and", "disability", ".", "We", "conducted", "a", "post", "hoc", "analysis", "to", "explore", "the", "potential", "efficacy", "of", "slowly", "progressive", "weight", "lifting", "to", "reduce", "the", "incidence", "of", "physical", "function", "deterioration", "among", "survivors", "of", "breast", "cancer", ".", "Between", "October", "2005", "and", "August", "2008", ",", "we", "conducted", "a", "single", "-", "blind", ",", "12", "-month", ",", "randomized", "controlled", "trial", "of", "twice", "-", "per", "-", "week", "slowly", "progressive", "weight", "lifting", "or", "standard", "care", "among", "295", "survivors", "of", "nonmetastatic", "breast", "cancer", ".", "In", "this", "post", "hoc", "analysis", "of", "data", "from", "the", "Physical", "Activity", "and", "Lymphedema", "Trial", ",", "we", "examined", "incident", "deterioration", "of", "physical", "function", "after", "12", "months", ",", "defined", "as", "a", "≥", "10", "-point", "decrease", "in", "the", "physical", "function", "subscale", "of", "the", "Medical", "Outcomes", "Short", "-", "Form", "36", "-item", "questionnaire", ".", "The", "proportion", "of", "participants", "who", "experienced", "incident", "physical", "function", "deterioration", "after", "12", "months", "was", "16.3", "%", "(", "24", "/", "147", ")", "in", "the", "control", "group", "and", "8.1", "%", "(", "12", "/", "148", ")", "in", "the", "weight", "lifting", "group", "(", "relative", "risk", ",", "0.49", ";", "95", "%", "CI", ",", "0.25", "to", "0.96", ";", "P", "=", ".", "04", ")", ".", "No", "serious", "or", "unexpected", "adverse", "events", "occurred", "that", "were", "related", "to", "weight", "lifting", ".", "Slowly", "progressive", "weight", "lifting", "compared", "with", "standard", "care", "reduced", "the", "incidence", "of", "physical", "function", "deterioration", "among", "survivors", "of", "breast", "cancer", ".", "These", "data", "are", "hypothesis", "generating", ".", "Future", "studies", "should", "directly", "compare", "the", "efficacy", "of", "weight", "lifting", "with", "other", "modalities", "of", "exercise", ",", "such", "as", "brisk", "walking", ",", "to", "appropriately", "inform", "the", "development", "of", "a", "confirmatory", "study", "designed", "to", "preserve", "physical", "function", "among", "survivors", "of", "breast", "cancer", "." ]

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[ "A", "randomized", ",", "double", "-", "blind", ",", "placebo", "-", "controlled", "study", "evaluating", "the", "efficacy", "of", "combination", "olanzapine", ",", "ondansetron", "and", "dexamethasone", "for", "prevention", "of", "chemotherapy", "-", "induced", "nausea", "and", "vomiting", "in", "patients", "receiving", "doxorubicin", "plus", "cyclophosphamide", ".", "Since", "most", "of", "Thai", "cancer", "patients", "receiving", "high", "emetogenic", "chemotherapy", "do", "not", "have", "access", "to", "neurokinin-", "1", "(", "NK-", "1", ")", "receptor", "antagonists", "or", "palonosetron", "as", "recommended", "by", "international", "guidelines", "for", "chemotherapy", "-", "induced", "nausea", "and", "vomiting", "(", "CINV", ")", "prevention", ".", "We", "decided", "to", "evaluate", "the", "efficacy", "of", "olanzapine", "with", "the", "real", "-", "life", "practice", "antiemetic", "drugs", "ondansetron", "and", "dexamethasone", ",", "in", "prevention", "of", "CINV", "resulting", "from", "doxorubicin", "plus", "cyclophosphamide", "regimen", "in", "early", "-", "stage", "breast", "cancer", "patients", ".", "In", "this", "randomized", ",", "double", "-", "blind", ",", "placebo", "-", "controlled", "trial", ",", "we", "compared", "olanzapine", "with", "a", "placebo", "in", "combination", "with", "ondansetron", "and", "dexamethasone", "in", "early", "-", "stage", "breast", "cancer", "patients", "receiving", "doxorubicin", "60", "mg", "/", "m", "2", "plus", "cyclophosphamide", "600", "mg", "/", "m", "2", ".", "The", "intervention", "group", "received", "olanzapine", "10", "mg", "orally", "while", "the", "control", "group", "received", "a", "matching", "placebo", "daily", "on", "day", "1", "through", "day", "4", ".", "All", "patients", "received", "ondansetron", "8", "mg", "and", "dexamethasone", "20", "mg", "intravenously", "30", "minutes", "before", "chemotherapy", "administration", "and", "then", "dexamethasone", "10", "mg", "daily", "orally", "from", "day", "1", "through", "day", "4", ".", "The", "primary", "endpoint", "was", "no", "nausea", "rate", "in", "the", "early", "period", ".", "The", "secondary", "endpoints", "were", "no", "nausea", "rate", "in", "the", "delayed", "and", "overall", "periods", "and", "a", "complete", "response", "(", "no", "vomiting", "and", "no", "use", "of", "rescue", "drug", ")", ".", "Outcomes", "were", "determined", "by", "patients", "'", "self", "-", "reported", "daily", "records", "of", "episodes", "of", "vomiting", "or", "retching", ",", "use", "of", "rescue", "therapy", "and", "daily", "levels", "of", "nausea", "based", "on", "a", "visual", "-", "analogue", "scale", "from", "the", "first", "cycle", "of", "chemotherapy", ".", "A", "total", "of", "39", "female", "patients", "were", "randomized", "in", "a", "1", ":1", "ratio", "to", "receive", "olanzapine", "(", "20", "patients", ")", "or", "a", "matching", "placebo", "(", "19", "patients", ")", ".", "A", "significantly", "greater", "proportion", "of", "patients", "reported", "no", "nausea", "in", "the", "olanzapine", "group", "than", "in", "the", "placebo", "group", "in", "both", "the", "early", "period", "(", "0", "-", "24", "hours", "after", "chemotherapy", ")", "and", "the", "overall", "period", "(", "0", "-", "120", "hours", "after", "chemotherapy", ")", ".", "Patients", "who", "reported", "no", "nausea", "in", "the", "early", "period", "accounted", "for", "50", "%", "and", "10.5", "%", "in", "the", "olanzapine", "group", "and", "in", "the", "placebo", "group", "respectively", "(", "P=", "0.008", ")", ".", "In", "the", "overall", "period", ",", "30.0", "%", "and", "0", "%", "of", "patients", "reported", "no", "nausea", "in", "the", "olanzapine", "and", "placebo", "groups", "respectively", "(", "P=", "0.009", ")", ".", "In", "the", "early", "period", ",", "there", "was", "a", "significantly", "different", "complete", "response", "rate", "between", "two", "treatment", "groups", ";", "75.0", "%", "in", "the", "olanzapine", "group", "and", "36.8", "%", "in", "the", "placebo", "group", "(", "P=", "0.016", ")", ".", "Overall", "treatment", "-", "related", "adverse", "events", "were", "not", "significantly", "different", "between", "the", "two", "study", "groups", "except", "that", "somnolence", "was", "significantly", "more", "common", "in", "the", "olanzapine", "group", "than", "in", "the", "placebo", "group", ".", "Olanzapine", "10", "mg", "combined", "with", "ondansetron", "and", "dexamethasone", "was", "more", "effective", "than", "a", "placebo", "in", "preventing", "CINV", "resulting", "from", "doxorubicin", "plus", "cyclophosphamide", "in", "early", "-", "stage", "breast", "cancer", "patients", ",", "especially", "in", "the", "first", "24", "hours", "after", "chemotherapy", "administration", ".", "The", "short", "duration", "of", "olanzapine", "was", "safe", "and", "well", "tolerated", "." ]

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