Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC11320084
p < 0.05, ##p < 0.01, compared with si‐TNNT1 + LiCl group.
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PMC10158546
Differentiated cultures made from the neural progenitor cell lines overexpressed PrP within 3D spheroid-like structures of TUBB3 neurons and we observed evidence that PrP modulates formation of these structures, consistent with PrP’s role in neurogenesis.
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PMC11633763
Protein and mRNA levels of β‐catenin assessed by western blotting and qRT‐PCR in osteosarcoma cells transfected with shUSP22 or shNC. (
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PMC11774747
Median persistence of CD19.CAR-EBVST was improved significantly with vaccination directed with EBV antigens: 0 day (range: 0-28) without vaccination compared to 56 days (range: 0-221) with vaccination (P=0.06).
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PMC7189327
Fourthly, the relevant clinical characteristics are also required to be collected to assess BCC prognosis.
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PMC11770746
The mice were acclimatized for 3 days and given access to food and water ad libitum.
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PMC10443665
Pure deionized water (1000 mL) was added and the mixture was kept on a magnetic stirrer at room temperature and gently stirred overnight.
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PMC11754291
Regazzetti et al. observed that primary cultures of melanocytes were greatly stimulated by blue light (Regazzetti et al., 2018).
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PMC11470381
Note: Ideally, any point within each bisected ROI would enable Fiji to use the Wand tool and detect each bisected ROI.
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PMC11488203
Taxol treatment of the different MSC revealed an up-regulation of tetraspanins and a 2.2-fold to 5.4-fold increased expression of SDF-1 among others.
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PMC11599565
Panel D: stemness and neuronal signature in primary OC cells cultivated in 2D.
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PMC10538569
Immature DCs (iDCs) play a significant role in promoting the dissemination and amplification of HIV-1 infection.
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PMC9429973
Our validation tests confirmed this metabolic dependency, MYC OE cell lines failed to proliferate in the context of glutamine starvation and showed higher sensitivity to CB-839 and V-9302 inhibiting GLS1 and SLC1A5, respectively.
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PMC10936243
There are multiple measures which have been identified to help improve cat care management in practice and these mainly involve continuous education and an awareness of the importance of post-operative cat care among stakeholders (veterinarians, veterinary assistant/ nurse and clients) and the establishment of well-written guidelines such as SOP to follow in practice.
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PMC11711127
Such Treg synapses exhibit constitutive recruitment of CTLA-4, but not CD28, compared with other cell types (141), which in turn outcompetes CD28 binding from naive cells further limiting their activation (140).
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PMC8193046
Compound was reported before .
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PMC11770130
For the adipose tissues, a 2 mg eWAT sample was added to 200 µL of water and 500 µL of methanol, and homogenized using the same approach as in the hydrophilic metabolite extraction above.
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PMC2118063
AICDA transcripts are detected only in peripheral lymphoid tissues, where they are almost exclusively associated with GC (56).
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PMC11731614
Fraction 2/3 KDEVs had sizes within the range of small EVs of 59.2 ± 14.5nm (RD; Fig. 1C) and 70 ± 26.3nm (HFD; Supplemental Fig. 2B) by dynamic light scattering (DLS) and concentration peaks at 95 ± 6.1nm (RD; Fig. 1D) and 86 ± 8.7nm (HFD; Supplemental Fig. 2C) by nanoparticle tracking analysis (NTA).
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PMC11723210
Stages 1 through 3 involve the generation and fusion of phase data from two planes, which serve as the initial input for Stage 4.
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PMC9429973
Functionally, TAP followed by MS analysis of BCAT1 interacting proteins disclosed that BCAT1 may be implicated in non-metabolic processes such as DNA replication and repair and rRNA processing.
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PMC11656657
E The graph shows the modulation of the distribution of CD4 + and CD8 + subpopulations of CAR.GD2 T-cells before (day 0) and after RD tumor cell addition at day + 5, + 10, + 15 and + 20.
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PMC11747467
The membranes were subsequently incubated with the corresponding secondary antibodies.
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PMC10577955
Following a 24-hour incubation period, A549 cells were treated with IC50 of ALUP, BA, and LUP for 48 h before being rinsed three times with ice-cold PBS.
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PMC11434983
Survival fractions were calculated and plotted as a function of the radiation dose on a semi-log scale.
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PMC11528603
Differences were statistically significant if P < 0.05.
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PMC9429973
γ-secretase) and released to the plasma as soluble proteins and can be easily detected using readily available commercial enzyme-linked immunosorbent assays (ELISA).
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PMC3995603
flavonoids (isorhamnetin, quercetin, isoquercitrin, hyperoside, etc.),
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PMC9964654
Unloaded micelles were prepared using the same procedure, in the absence of the gold complex (Figure 2).
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PMC11740907
Moreover, the computational findings demonstrate a strong connection with the actual data, providing a plausible explanation for the notable chemopreventive efficacy of POM against HeLa cell lines.
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PMC9429973
The most frequent reason was joint bleeds(59.6%, N=28).
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PMC6684588
The robust activity of ACE-083 observed here depends on its ability to sequester and neutralize multiple TGFβ superfamily ligands acting as homeostatic inhibitors of muscle growth.
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PMC11767582
Triazole derivative 3a, with no substitution on the B-ring, was found to be non-cytotoxic in the concentration range tested for any cell line, as well as compounds mono-substituted at the ortho position with bromine (3b) or nitro groups (3c) (Table 3).
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PMC11697703
We found that GoF of either miR-193b or miR-365 results in a significant increase in neurite branching compared to scrambled controls, whereas either miR-193b or miR-365 LoF results in a significant decrease in neurite branching compared to scrambled controls (Figures 4B and 4C).
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PMC11720808
To establish 143B osteosarcoma cells stably overexpressing TLR4 (TLR4 OE), pLVX-TLR4-FLAG plasmids, psPAX2 packing vector, and pCMV-VSV-G envelope vector were transfected into HEK293T cells to obtain supernatant containing lentivirus.
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PMC9429973
Immunofluorescence experiments were performed to assess if SETD2 forced expression was able to restore DNA damage repair by using p-H2AX (S139), RAD51, MSH6 and THEX1 antibodies.
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PMC11783017
XPS spectrum of Mn@Lipo-IL11. (
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PMC11506827
no. 9542S), caspase-3 (cat.
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PMC6182045
Previous studies have indicated that binding of gp120s to different bNAbs varies considerably as a result of primary sequence, glycan occupancy, and higher order structure (26, 27).
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PMC11347429
Blue: not significant genes with an adjusted p-value < 0.05.
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PMC11754094
Read pairs in category (1) are considered wildtype.
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PMC8193046
Finally, the 846 compounds were screened for the extended positive hits.
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PMC11789597
B and C) A heatmap showing the normalized mean expression of the indicated markers in 15 FlowSOM clusters of (B) MM1S or (C) RPMI 8226 cells. (
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PMC6835428
IGROV1, characterized by few CNAs and many mutations not present in HGSOC, resembles the molecular features of the endometrioid carcinoma.
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PMC7053076
Amplification of cDNA was performed using Real-Time 2x-PCR SYBR Master Mix (A&A Biotechnology, Gdynia, Poland) and gene specific primers (RelA, RelB, NF-κB1, NF-κB2 and c-Rel) (Table 1) in Stratagene MX3005P QPCR System (Agilent Technologies, Inc. Santa Clara, CA, USA) according to the manufacturer’s protocol.
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PMC11665584
R code that was used to process, analyze, and present scRNA-Seq and Xenium data was deposited to GitHub repository overmillera/pitx1-2024-jci-insight (https://github.com/overmillera/pitx1-2024-jci-insight; commit ID ab0222476d335ddc7099c1e7f964521e8b94ed46).
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PMC11686380
Error bars indicate SD from 10 to 15 neurons; *p < 0.05 and ****p < 0.0001 by one-way ANOVA and Dunnett’s post hoc test (vs. control). (
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PMC11555465
The optical density (OD) was measured at 450 nm using a microplate reader (Multiskan GO; Thermo Fisher Scientific, Inc.).
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PMC9111184
These findings allow to suggest that herbal infusions containing these compounds might be used as cholesterol reducing agents and by the way avoiding the side effects of Ezetimibe.
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PMC11583010
Finally, this study illustrated that exatecan has a rather slow and long-lasting cytotoxic effect, as tumor regression was only observed later than 7 days after injection of ETx-22.
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PMC11092382
In addition, sophocarpine had no effect on the generation and trafficking of the hERG protein (Zhao et al., 2008).
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PMC11767817
The experiments were performed as three independent experiments.
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PMC8592717
The antioxidant potential of PCA and PAL by increasing the activity of endogenous antioxidant enzymes glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD) has been reported in recent studies.
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PMC7334607
Of importance, a cell line with the same genotype may have varying fitnesses (EC50s) under the selection pressure of different drugs.
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PMC11803149
On day 12 after the adoptive transfer of young or aged OT-I TCR-T cells into young recipient mice with B16-OVA tumors, we collected tumor-infiltrating lymphocytes and sorted OT-I TCR-T cells (CD3, CD8, ZombieNIR and GFP).
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PMC11001582
Brains and spinal cords were embedded in optimal cutting temperature (OCT) compound (Tissue Tek, Sakura), and 10-μm sections were cut with a cryostat (CM1860 UV, Leica Microsystem).
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PMC7504302
These genes were previously reported to be overexpressed in MPM .
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PMC10940855
Femurs were then washed three times with PBS under agitation and then incubated in 10 mL of 0.5 mol/L EDTA solution (pH 7.4) for 24 hours under constant agitation at 4°C.
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PMC9960565
Pt-NMR (86 MHz, D2O) [ppm]: δ = −2120.93 (PtO2).
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PMC10812665
As they were among the hits, they served as positive controls in the present mechanistic study.
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PMC7612475
Despite this, we observed that SF3B1 cells exhibited an inability to properly recruit Rad51 to sites of stalled/damaged replication forks.
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PMC11345828
Comparison of Cellular Activity and PK of 1,3,5-Trimethylpyrazole (18), 4,6-Dimethylpyrimidine (19), and 2,4,6-Trimethylpyrimidine (20) Compounds.
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PMC11787381
Kolliphor P407 (POE101-POP56-POE101 triblock copolymer) and Kolliphor P188 (POE75-POP30-POE75 triblock copolymer) were gifts from BASF (Levallois-Perret, France).
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PMC11796104
One study reported elevated levels of hsa-miR-93-5p in osteoporotic patients .
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PMC11698348
Furthermore, loss and gain of Elf5 functions result in depletion of trophoblast SCs, in vitro and in vivo .
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PMC3888431
The de novo assemblies were screened for all possible open reading frames (ORF) ≥200 nt.
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PMC10669128
Therefore, in vivo models can compensate for in vitro weaknesses.
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PMC11790971
For each cross-validation fold, balanced accuracies were calculated on test set cells from monoclonal wells, while impurity scores were calculated on test set cells from all wells.
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PMC9429973
Evaluating the elderly must be using objective tools to distinguish the category of patients unfit for an intensive treatment.
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PMC11697703
G, and K) Coronal sections of P14 brain electroporated at E15 with miR-193b (red) and miR-365 (green) in (G), and with miR-Scrambled control constructs (green) in (K), immunolabeled for MAPK8 (magenta). (
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PMC10873328
The univariate Cox regression analysis of 6 hypoxia-related genes. (
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PMC9429973
We identified the most prominent NFAT member and assessed its activation under BTZ treatment.
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PMC7053076
Data are expressed as mean ± SEM Statistical significance was assessed by test t. *p < 0.05, ** p < 0.01, *** p < 0.001 Real-time PCR analysis of c-Rel, RelA, RelB, NF-κB1 (p100/p50), and NF-κB2 (p100/p52) mRNA levels in HL-60 cells treated with U-332 (a) and BGD (b).
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PMC11680049
However, for cultures grown in light, the reaction to polyphenols was widespread and exhibited greater intensity, particularly regarding flavonoid compounds (Figure 8b–d).
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PMC9429973
CHIP is associated with accelerated epigenetic age (Robertson et al. Curr Biol 29, R786–R787, 2019; Nachun et al., Aging Cell, 20, e13366, 2021) and especially with intrinsic measures of epigenetic age, i.e. measures which reflect cell-type independent effects of aging on DNA methylation, as opposed to extrinsic measures that reflect age-related changes to the immune-cell composition of the peripheral blood.
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PMC11585587
MM.1 S, MM.1R and RPMI 8226 cells in the logarithmic growth phase were inoculated into 96-well cell culture plates at the same density.
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PMC10237474
Analytical SEC was performed using HPLC (Agilent 1200 series) on a Yarra 3 μm SEC-2000 LC 300x4.6 mm column (cat no. 00H-4512-E0, Phenomenex) with a flow rate of 0.35 mL/min and a run-time of 15 min in 50 mM Tris, 0.5 M arginine, 0.05% sodium azide, pH 7.0.
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PMC10890307
Although it is often assumed that tumor clones show a similar growth rate with little variations in nutrient consumption, the present study shows how growth-specific rate (µ), the specific rates of glucose, lactate, and glutamine consumption (qS), and the specific rates of lactate and glutamate production (qP) of 2D-cultured lung tumor cells are affected by changes in their environment.
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PMC9848491
The patients in the whole dataset were calculated based on the formula for each patient’s risk score, and the patients were divided into high-risk group and low-risk group by referring to the median risk score.
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PMC11126803
The latest research also found that certain LncRNA may have important roles in the drug resistance of RCC (34).
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PMC10898159
So deeply exploring the key gene expression and regulation process of ICC lineage-specific differentiation or the compelling molecules impact its physical function such as gut motility, may offer the possibility of novel promising targets.
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PMC11697189
Immune cells are one of the main components of tumor microenvironment.
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PMC11502443
This is consistent with lower accumulation of IP1 and phosphorylation of AKT, ERK1/2, and to a lesser extent, CREB.
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PMC11317131
Successful events require precise and directional recombination to generate the attL site.
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PMC9429973
CDK6 acts in a kinase-dependent and kinase-independent way to regulate haematopoiesis.
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PMC11092382
Furthermore, they identified that sophocarpine mitigated DSS-induced colitis inflammation and intestinal fibrosis by modulating the SIRT 1/NF-κB p65 signaling pathway, reversing the senescence-associated secretory phenotype (SASP) and fibroblast-into-myofibroblast transition (FMT) of fibroblasts, as well as maintaining intestinal mucosal homeostasis (Jiang et al., 2024).
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PMC11621493
Lipids were emulsified in 100 mM potassium phosphate buffer (pH 7.4) supplemented with 5% BSA (FA free).
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PMC11568601
Wight et Arn.,
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PMC6835428
The effects of DFP-10825 alone or in combination with PTX were tested in a xenograft orthotopic model of OC generated by SKOV3-luc implantation in the peritoneum.
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PMC9429973
T. A. Eyre, L. Hess, T. Sugihara, R. A. Walgren, P. B. Abada, H. Konig, J. Pagel, L. E. Roeker, A. Mato Oxford University Hospitals, NHS Foundation Trust, Oxford, United Kingdom; Eli Lilly and Company, Indianapolis; Syneos Health, Austin; Loxo Oncology, Stamford; Memorial Sloan Kettering Cancer Center, New York, United States of America Background: Covalent Bruton tyrosine kinase inhibitors (cBTKi) and B-cell lymphoma 2 inhibitors (BCL2i) have improved the outcomes for patients with CLL/SLL.
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PMC11547972
Potent synergism between amygdalin and triple drug combinations has also been reported .
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PMC11534035
Treatment with 1 μM and 2.5 μM of G36 showed a slight but non-significant increase in the average number of tumor spheres.
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PMC10818062
Last but not least, PE was also affected by PS inhibition.
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PMC11718274
Briefly, a 100 µL normal HSF and cancerous A-431 cells (100 ) cell suspension were separately cultured in 96-well plates and incubated for 24 h in complete media.
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PMC10978090
17 Here, we report two patients on ECMO with acute HIT who beneficiated from TPE before thoracic surgery.
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PMC10376064
APPPS1-21 mice have a combined APP (Swedish mutations) and PS1 (L166P mutation) transgene under the control of the Thy1-promoter, leading primarily to pathological Aβ production in the fronto-cortical neurons and the first cortical Aβ plaques at 45–50 days of age, which also occurs much later in other brain regions, but to a significantly lesser extent (e.g., hippocampus) .
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PMC10560648
The relative quantification of gene expression were calculated using 2 method.
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PMC9812014
MLVs are Gammaretroviruses that cause malignancy in their murine (mouse) hosts.
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PMC8348645
In linear mobile phase, 50% of acetonitrile and 50% of HPLC grade water was used.
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PMC10530622
Lithiasis has been related with the gut microbiota, mainly due to calcium and oxalate metabolisms.
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