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PMC11576293
For C19H19N2O2S (M + H) 339.11618; found 339.11696.
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PMC9429973
Patients with D-dimer levels ≥ 0.5 µg/mL fibrinogen equivalent units (FEU) were referred to whole-leg compression ultrasonography (CUS) to confirm/exclude the DVT diagnosis.
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PMC6892818
mCD40L caused rapid upregulation of TRAF1 in all RCC lines, in comparison to low basal expression.
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PMC11509224
It was found that (−)-agelamide D enhanced the radiation sensitivity of Hep3B cells, reducing their ability to form colonies and boosting the rate of apoptosis .
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PMC11472639
This is thought to be due in part to failure of antibody-dependent cellular cytotoxicity (ADCC) – a mechanism-of-action of daratumumab exerted by NK-cells and by monocytes (Nijhof et al., 2015).
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PMC6889484
To determine the infectivity of A3G(DK), A3dr(DK), 3Gdr(DK), and A3x3G(DK) viruses, normalized p24 CA amounts were used to transduce target 293T cells (4 × 10 cells per 6-well plate).
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PMC6934009
Moreover, the wogonin molecules have a flavonoid structure, which may bestow an anti-proliferative activity to it.
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PMC11794588
The antioxidant activity of β-amyrin was demonstrated in C. elegans by Rani et al., where it was shown to protect against oxidative stress.
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PMC11470999
Seven days post‐inoculation, the mice were randomly divided into three groups of six and treated according to the same regimen as in the subcutaneous tumor treatment experiment.
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PMC11365427
TIC chromatograms from UPLC/MS detection exhibited typical peak features.
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PMC11489175
Such hallmarks have increased with time, but already in 2000 a major contribution of signaling sustaining tumor cell survival was recognized 12.
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PMC11026382
c Correlation between experimentally measured and computationally inferred log10(kcat/Km) values for 38 mutants of DHFR.
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PMC10743717
it was again emphasized that “…generalized alcohol dehydrogenase activity, in addition to HADH activity, lead us to propose the new name Aβ-binding protein alcohol dehydrogenase or ABAD to better describe the unusual properties of the enzyme previously referred to as ERAB”.
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PMC11413393
n = 5 mice/ group (RCC243 PDX), n = 10 mice/group (RCC63 PDX).
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PMC10033453
BALB/c mice were inoculated subcutaneously with WEHI 164.
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PMC7039683
We also carried out unsupervised hierarchical clustering based on the frequency and combinations of motifs they contained (Figure 2—figure supplement 4A), but did not detect any striking patterns.
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PMC11792090
Mice blood was collected on Day 4, 8, 12, 16 and 28, and real-time quantitative PCR results demonstrated a significantly higher number of CD70 CAR copies in the SAP UCAR-T group ( Figure 6G ).
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PMC9429973
Burden of comorbidities was assessed using the Charlson-comorbidity-index (CCI).
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PMC11538390
Furthermore, the risk allele (G) of rs570516915 is linked (D′ = 1.0, r = 0.0034) to the non-risk allele (also G) of the previously described common CL/P risk variant rs642961 in the same enhancer, suggesting that the association signals are independent of one another.
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PMC6450504
Compared to control groups, 0.5%PEIPOS association increased 88% (Figure 3(a)).
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PMC11707832
Human MAN2B1 is characterised by 11 glycosylation sites, where eight of these sites align with the conserved positions identified in the bovine MAN2B1.
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PMC11761919
p < 0.01, ***p < 0.001.Fig 2 Internalization of PINs into Fiber2-expressing E. faecalis and Fiber2 protein expression in host bacteria. (
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PMC11271278
G. Enhancer distribution of MYC and the additional oncogenes harbored in the amplicon found in NCIH446 cells.
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PMC9352806
As expected, the activation of AMPK phosphorylation and LC3B expressions were observed in BMS treatment group, compared with the model group, imply that BMS could stimulate autophagy to respond the OA-induced fat accumulation.
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PMC8759873
VHL gene has the functions of regulating transcription, regulating cell cycle, and stabilizing cell growth-related genes.
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PMC9429973
In addition, del(17q) cases had a higher number (≥5) of copy number abnormalities (p<0.001).
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PMC9429973
Cell-free DNA concentration ranged from 0.45 ng/µl to 85.60 ng/µl (median conc, 0.67 ng/µl), which showed no apparent correlation with the serum level of LDH, sIL-2R, or imaging status.
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PMC9429973
Sufficient data for phenotype-genotype correlation testing were available for 56 patients (core group, N=35), and phenotypes were milder in the patients with SLC4A1 variants.
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PMC7762347
Namely, the toxin induces DNA single-strand breaks that are repaired after prolonged exposures and it does not induce micronuclei in HepG2 cells .
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PMC6160470
Next day, cells were treated with compounds alone or in combinations at indicated concentrations.
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PMC8751435
Thus, CME‐induced cell bubbling or cell lysis may exhibit indirect anticancer effect through pyroptosis‐involved immunity response.
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PMC11768281
Full-text screening of 67 articles resulted in the exclusion of 4 articles, leaving 63 studies in the final review.
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PMC9398137
On D1, all mice were stratified so that all cohorts contained mice with comparable calculated tumor volumes.
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PMC9429973
However, no information has been found on its association with CLL, which presents autoimmune complications in 25% of cases.
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PMC11583690
In contrast, MSN nanoparticles exhibited a higher but less stable zeta potential, beginning at −18.43 mV and decreasing to −10.91 mV over the same period.
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PMC11585994
Notably, nanoparticles conjugated with sgc8 demonstrated superior delivery efficiency.
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PMC11127909
Mitochondria, a kind of dynamic subcellular organelle, are a powerhouse of cell energy metabolism and a crucial regulator of cell death .
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PMC11394386
RNA binding protein immunoprecipitation (RIP) with specific antibodies to DNMT1 (abcam, Ab92314), β-catenin (abcam, ab22656) and HIF1α (Invitrogen, PA116601) was conducted using the Magna RIP RNA-binding protein immunoprecipitation kit (17–704, EMD Millipore, Burlington, MA, USA).
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PMC9429973
Methods: Patient was administered as a single intravenous dose at dose level 1 (2x10 cells/kg), dose level 2 (7x10 cells/kg) or dose level 3 (2x10 cells/kg).
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PMC11761919
All animal experiments were conducted at the Veterinary Hospital of Northeast Agricultural University, China, following the Ethics Committee for Animal Sciences Regulations at Northeast Agricultural University, Heilongjiang Province, China (NEAUEC20210332).
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PMC5874706
Using fluorescent techniques, the interactions of nanoparticles with cells can be revealed.
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PMC4360730
The derives_from relationship indicates that the child term succeeds parent term over some temporal divide, such that at least a significant biological portion is inherited (e.g. hepatoma cell lines—EFO:0005216 are cancerous hepatocyte cells—CL:0000182).
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PMC9596868
For quantification of γ-H2AX foci, random fields of cells from each slide were quantified manually and calculated using the formula: Percentage of total γ-H2AX positive cells = (No. of cells containing ≥5 foci/ total number of cells) x 100.
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PMC10890055
This was confirmed for hFOB 1.19 (Figure 4), where the toxic effect of ZnCl2 was lower in the case of rich DMEM/Ham’s F-12 compared to the minimal medium MEM.
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PMC11547917
The ABTS assay was chosen as a different method; to our knowledge this method was used for the first time in the literature to test Aristolochia sp. extracts or compounds for antioxidant activity.
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PMC10530622
These innovative therapies show significant promise in alleviating the burden of PH and may potentially decrease the need for more invasive procedures such as organ transplantation.
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PMC9429973
There were 7 patients with a 6-month FU after switching at which 6 of them had a LDH below 1.5 × ULN.
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PMC8623816
Finally, transcriptome technology was used to explore the molecular mechanism of the interaction between RsRV5 and R. solani AG-1 IA.
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PMC9429973
Among the 13 patients evaluable, the ORR is 62%(n=8).
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PMC11739504
Nuclei were stained with DAPI (blue).
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PMC9672323
Given that high lactate levels diminished antitumor T cell responses, this finding suggested that piroxicam might counteract lactate-induced immunosuppression by limiting tumor metabolism in the tumor microenvironment.
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PMC11258145
They offer a good means of investigating how substances present in the membrane environment can alter their mechanical properties.
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PMC9509578
Dearden et al. demonstrated that drug-functionalized gold nanorods (AuNRs) mediated P-gp trafficking in P-gp + J774.2 cells.
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PMC11541409
Providing evidence that the development of new TKIs to overcome primary and secondary mutants is possible.
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PMC11453018
The treatment reduced cell viability in a dose-dependent manner across all tested ES cell lines.
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PMC9739791
In addition, the role of FMNH as the active catalytic particle was confirmed by monitoring the evolution of UV-Vis spectra.
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PMC11252033
Fragments populating the hotspots identified within the NADPH (magenta) binding region are highlighted in yellow; fragments in cyan are found within an additional hotspot.
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PMC4270159
KHM-3S cellspEGFRpAKTpERKpMETControl1111Erlotinib alone0.0080.6090.181.098Erlotinib + HGF0.0141.3810.97911.66Erlotinib + HGF + Crizotinib0.0230.4170.0851.095• HGF activates pMET and pERK in the presence of Erlotinib.• Crizotinib blocks HGF-induced pMET and pERK activation. •
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PMC10955424
Multiple cell types, including immune cells, fibroblasts, adipocytes, and mesenchymal stem cells (MSC), constitute the cellular compartment of TME.
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PMC10055960
All reactions were carried out using standard Schlenk techniques under an inert (N2) atmosphere.
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PMC9429973
Aims: The aim of this trial was to determine the efficacy and safety of acalabrutinib in patients with treatment-naive (TN) or relapsed/refractory (R/R) WM.
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PMC6835428
A syngenic mouse model has been generated using murine ovarian surface epithelial cells from C57BL/6 mice, which have been subsequently transformed (ID8 cells) and eventually re-injected into C57BL/6 mice .
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PMC9784246
Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020 .
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PMC11310713
Unlike premenopausal women where endogenous hormones are active, the increased incidence of breast cancer in postmenopausal women undergoing exogenous hormone therapy (pharmaceutical HRT) suggests this difference clinically.
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PMC11248911
HNMR (DMSO-d6, δ ppm): 1.08–1.12 (t, 3H, CH3, 7.2 Hz), 2.23 (s, 3H, CH3), 3.31–3.37 (dd, 1H, pyrazoline, J = 8.32, 18.24 Hz), 3.43 (br m, 2H, CH2), 3.49–3.56 (dd, 1H, pyrazoline, J = 9.44, 18.24 Hz), 5.08–5.13 (dd, 1H, pyrazoline, J = 8.96, 11.52 Hz), 7.42–7.49 (m, 5H, Ar–H), 8.78 (s, 1H, NH, D2O exchangeable).
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PMC11413393
DNA was extracted using a QiaAMP DNA mini kit (Qiagen).
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PMC10823017
ICA-1 treatment also shows a reduced level of association between aPKC and c-Myc.
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PMC11593031
The heterochromatic nature of these regions originating from the centromere-proximal sub-band A1 of any mouse chromosome is depicted in Figure 5.
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PMC11765879
Next, membranes were probed with secondary antibodies, and the resulting protein bands on the blots were detected by ECL Western blotting substrate 46 (Thermo Fisher Scientific) using the Bio-Rad Chemidoc MP Imaging System.
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PMC9065483
B, C) 786-0 cells were simultaneously treated with varying concentrations of IMD-0354 or SC-514 (0–2000 nM) and vanadate (150 μM) (n = 2, mean ± SEM).
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PMC2614416
A child node that represents a more specific instance of a parent node is designated as 'is a' whereas 'part of' denote a child term node that is a constituent of the parent node term.
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PMC11679033
Considering this fact, results of our research document that human lymphocytes already after 24 h of exposure showed a very high sensitivity to the harmful effects of CIT at a concentration twice as low as that one previously described in the same experimental model.
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PMC11360263
If HCMV gene products are indeed responsible for causing DNA damage, impairing DNA repair mechanisms, and stimulating proliferation in stem cells, then HCMV could potentially trigger the onset of cancer.
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PMC3019555
The microtubule cytoskeleton is an extensive network of filaments that undergoes constant remodeling according to its role in diverse cellular functions, ranging from cell division to intracellular trafficking.
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PMC11055323
n = 5 condensates.
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PMC11596967
The measured doses were confirmed to be within 5% of the intended doses of 2, 4, 6, or 8 Gy.
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PMC10887351
In mice models with the Gαs subunit deleted (adipo-Gαs-KO knockout), it was observed the lipolysis of adipocytes through β3-AR stimulation of the cAMP-PKA pathway, which improved perilipin phosphorylation and triglyceride hydrolysis in response to β3-AR agonism and reduced the FFAs levels .
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PMC11774747
Preclinical studies show that CAR-VST efficiently lyse tumor cells expressing the targeted tumor antigen, underscoring specific MHC-independent killing.
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PMC10506676
The data were computed in Microsoft Excel after Ct normalization.
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PMC11806182
The role of miRNAs in immune modulation, hormonal signaling, and metabolic reprogramming offers new opportunities for therapeutic intervention.
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PMC9895440
Antibodies targeting CD14, CD11b, CD4 and CD19 were used to gate out potentially contaminating other immune cell populations.
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PMC11742431
The working proteins were incubated with 5637 cells, and indirect immunofluorescence and western‐blot results showed that KVN and K14N could effectively degrade the Survivin protein in the cytoplasm.
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PMC11626627
Increasing evidence suggests that ERβ plays a role in promoting the progression of ccRCC .
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PMC11755624
Since the discovery of PRINS and its potential involvement in psoriasis, numerous other lncRNA molecules were identified and investigated.
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PMC9429973
A. Koehler, M. Moise, T. Call, K. Rabe, S. Achenbach, D. Crusan, K. Bailey, T. Petterson, W. Ding, S. Kenderian, J. Leis, Y. Wang, E. Muchtar, P. Hampel, S. Schwager, S. Slager, N. Kay, A. Ashrani, S. Parikh Hematology; Biostatistics, Mayo Clinic, Rochester; Hematology, Mayo Clinic, Scottsdale, United States of America Background: Data on risk of VTE after MBL/CLL diagnosis is limited;it is unclear if MBL/CLL truly confers increased risk of VTE as seen in other malignancies.
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PMC9429973
Methods: Our study includes 111 MM patients (51 male) aged 19 to 65 (median age 53) who performed an auto-HSCT between 2018 and 2020.
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PMC8973085
calcd for C26H24FN3O3S: C, 65.39; H, 5.07; N, 8.80.
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PMC11507371
The most important stimuli include bacterial lipopolysaccharide, tumour necrosis factor (TNFα), interleukin (IL)-1β, as well as ribotoxic, genotoxic, oxidative, and shear stress .
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PMC8839885
Moreover, the combination with cobimetinib significantly reduced levels of cPARP as a result of exposure to RJY13 in the presence of fisetin, demonstrating that the activity of fisetin in restoring platinum drug sensitivity to OC cells is dependent on ERK1/2 activity (Figure 3D) .
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PMC11537649
Correlation between miR-152-3p and CDK6 was assessed by Pearson correlation coefficient test. (
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PMC11632064
It is likely that a wide variety of mechanisms may explain the involvement of mitochondrial proteins in resistance to PLK1 targeting.
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PMC10123657
Proteomic datasets have been submitted to the MassIVE repository (MSV000090911 and MSV000090943, https://massive.ucsd.edu/ProteoSAFe/static/massive.jsp, accessed on 15 December 2022).
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PMC10919056
Patients in high-RS subgroup presented with higher TMB than that in low-RS subgroup (Figure 8A).
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PMC11574029
For the subcutaneous xenograft model, 5 × 10 stably transfected cells (n = 6 per group) were injected subcutaneously into the abdominal region of 4–5-week-old female BALB/c nude mice.
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PMC11519583
g Fluorescence intensity of SPiDER-βGal in MPs treated with the indicated siRNAs was monitored by flow cytometric analysis.
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PMC11699178
The cells were cultured in RPMI1640 medium (Gibco, Cat.
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PMC9429973
Adding polatuzumab vedotin to R-GemOx (Pola-R-GemOx) may improve outcomes for patients with a continued unmet medical need.
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PMC11119602
The molecular complex was stabilised by hydrogen bonds, salt bridges, and non-bonded contacts (Figure 7).
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PMC11540664
However, a significant proportion of patients do not benefit from additional combination therapy, and the overall toxicity of combination regimens is high.
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PMC11206251
After being washed twice with PBS, 500 μL 1×Binding Buffer was added to re-suspend the cells, and 5 μL Annexin V-FITC staining solution and 10 μL propidium iodide (PI) staining solution were added at room temperature for 5 min, detected by flow cytometry (Becton Dickinson, Franklin Lakes, NJ, USA).
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