NothingMuch/GO-Terms huggingface dataset:
Catalysis of the reaction: a long-chain 2,3-saturated fatty acyl-CoA + O2 = a long-chain (2E)-enoyl-CoA + H2O2.
long-chain fatty acyl-CoA oxidase activity
Catalysis of the reaction: choline = acetaldehyde + trimethylamine.
choline trimethylamine lyase activity
Catalysis of the reaction: an L-polyhomomethionine + 2 O2 + 2 reduced  = an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + 2 H(+) + 3 H2O + 2 oxidized .
homomethionine N-monooxygenase activity
Catalysis of the reaction: 3'-phosphoadenylyl sulfate + an aliphatic (Z)-desulfo-glucosinolate = a (Z)-omega-(methylsulfanyl)-N-sulfo-alkylhydroximate S-glucoside + adenosine 3',5'-bisphosphate + H+.
aliphatic desulfoglucosinolate sulfotransferase activity
Catalysis of the reactions: a 2-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O and a 3-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O.
2-(omega-methylthio)alkylmalate dehydratase activity
Catalysis of the reaction: (-)-secoisolariciresinol + 2 NAD+ = (-)-matairesinol + 2 H(+) + 2 NADH.
secoisolariciresinol dehydrogenase activity
A protein complex that regulates the TORC1 signaling pathway in response to nutrients. The KICSTOR complex is composed of KPTN, ITFG2, C12orf66 and SZT2.
KICSTOR complex
The directed movement of L-aspartate from outside of a cell, across the plasma membrane and into the cytosol.
L-aspartate import across plasma membrane
Enables the transfer of D-aspartate from one side of a membrane to the other.
D-aspartate transmembrane transporter activity
Any process that modulates the ability of the cytoplasmic translational apparatus to interpret the genetic code.
regulation of cytoplasmic translational fidelity
A protein complex that possesses DNA methyltransferase activity.
DNA methyltransferase complex
The process in which ADP is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial ADP transmembrane transport
The directed movement of an endosome towards the plus end of a microtubule, mediated by motor proteins. This process begins with the attachment of an endosome to a microtubule, and ends when the endosome reaches its final destination.
plus-end-directed endosome transport along mitotic spindle midzone microtubule
The formation of a transient pore in the plasma membrane and the attached contractile vacuolar membrane, to release water from the cell. This process does not involve fusion of the two membranes.
pore formation during contractile vacuole discharge
Binding to a protein upon glycosylation of the target protein.
glycosylation-dependent protein binding
The conversion of polycistronic RNA transcribed from a mitochondrial genome into mono- or bi-cistronic RNAs.
mitochondrial polycistronic RNA processing
The attachment of a mitochondrial membrane to a vacuolar membrane via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.
vacuole-mitochondria membrane tethering
The process in which the terminal anatomical structures of an axon are generated and organized into branches of specialised projections, or boutons. An axon is the long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminal branches.
axon arborization
The butyrylation of a lysine residue in a protein. Butyryl is the univalent radical C3H7COO- derived from butyric acid.
peptidyl-lysine butyrylation
Catalysis of the reaction: crotonyl-CoA + histone = CoA + crotonyl-histone.
histone crotonyltransferase activity
Catalysis of the reaction: butyryl-CoA + histone = CoA + butyryl-histone.
histone butyryltransferase activity
Any process that stops, prevents or reduces the frequency, rate or extent of lipoprotein transport.
negative regulation of lipoprotein transport
Any process that activates or increases the rate or extent of lipoprotein transport.
positive regulation of lipoprotein transport
Binding to a glycosylated region of a protein.
glycosylated region protein binding
Isoenergetic transfer of SUMO from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.
SUMO-ubiquitin ligase activity
Preferential binding of proteins on curved membranes. The binding to curved membranes by insertion (aka wedging) to curved membranes is mediated by both the hydrophobic and hydrophilic faces of the helix of membrane curvature sensing (MCS) proteins.
membrane curvature sensor activity
Enables the transfer of potassium ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
high-affinity potassium ion transmembrane transporter activity
Catalyzes the activation of choline trimethylamine-lyase by generation of an organic free radical on a glycine residue via a homolytic cleavage of S-adenosyl-L-methionine (SAM).
-activating enzyme activity
Any process carried out at the cellular level that reduces or removes the toxicity of a fluoride. These may include chemical modification or transport of fluoride away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
cellular detoxification of fluoride
The directed movement of fluoride ions from inside of a cell, across the plasma membrane and into the extracellular region.
fluoride export across plasma membrane
Any process that stops, prevents or reduces the frequency, rate or extent of Lewy body formation.
negative regulation of Lewy body formation
Any process that activates or increases the frequency, rate or extent of Lewy body formation.
positive regulation of Lewy body formation
The directed movement of thiamine from outside of a cell, across the plasma membrane and into the cytosol.
thiamine import across plasma membrane
Binding to an iron-sulfur cluster and delivering it to an acceptor molecule.
iron-sulfur cluster carrier activity
The process in which a guanine nucleotide is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial guanine nucleotide transmembrane transport
The process in which a potassium ion is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial potassium ion transmembrane transport
The directed movement of copper ions out of the vacuole across the vacuolar membrane.
copper ion export from vacuole
The directed movement of calcium cations into the vacuole across the vacuolar membrane.
calcium ion import into vacuole
The directed movement of zinc ions from inside the vacuole across the vacuolar membrane and into the cytosol.
zinc ion export from vacuole
The directed movement of an ammonium ion from outside of a cell, across the plasma membrane and into the cytosol.
ammonium import across plasma membrane
The directed movement of borate from inside of a cell, across the plasma membrane and into the extracellular region.
borate export across plasma membrane
Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process.
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
Any process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating adrenergic receptor signaling pathway involved in some heart process.
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
The directed movement of urea from outside of a cell, across the plasma membrane and into the cytosol.
urea import across plasma membrane
The directed movement of spermidine from outside of a cell, across the plasma membrane and into the cytosol.
spermidine import across plasma membrane
The directed movement of pyridoxal from outside of a cell, across the plasma membrane and into the cytosol.
pyridoxal import across plasma membrane
The directed movement of a dipeptide from outside of a cell, across the plasma membrane and into the cytosol.
dipeptide import across plasma membrane
Any process in which a protein is transported to the kinetochore along a microtubule.
protein transport along microtubule to kinetochore
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: folic acid(out) + H+(out) = folic acid(in) + H+(in). The main folic acid symporter is the Proton-Coupled Folate Transporter (PCFT/SLC46A1), which has similar affinity for transport of reduced folates (5-methyl THF, 5-formyl THF) and folic acid.
folic acid:proton symporter activity
Any process that stops, prevents or reduces the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol.
negative regulation of D-aspartate import across plasma membrane
Any process that activates or increases the frequency, rate or extent of the directed import of D-aspartate from the extracellular region across the plasma membrane and into the cytosol.
positive regulation of D-aspartate import across plasma membrane
A protein complex that regulates Arp2/3 complex-mediated actin nucleation.
SLAC complex
Catalysis of the transient cleavage and passage of individual RNA strands or double helices through one another, resulting a topological transformation in RNA.
RNA topoisomerase activity
The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons.
anterograde axonal transport of neurotransmitter receptor complex
A polyadenylation event (the enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule) that takes place at a postsynapse.
RNA polyadenylation at postsynapse
Translation that occurs at the presynapse, and that modulates chemical synaptic transmission.
translation at presynapse, modulating chemical synaptic transmission
Translation that occurs at the postsynapse.
translation at postsynapse
The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse.
protein catabolic process at presynapse
The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse.
protein catabolic process at postsynapse
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse.
regulation protein catabolic process at presynapse
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse.
regulation protein catabolic process at postsynapse
Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to phosphate starvation.
negative regulation of cellular response to phosphate starvation
Binding to a PRC1 complex.
PRC1 complex binding
Binding to a mitochondrial proton-transporting ATP synthase complex.
mitochondrial proton-transporting ATP synthase complex binding
Binding to a mRNA cap binding complex.
mRNA cap binding complex binding
Peroxisome-derived dense-core vesicle that seals septal pores upon hyphal lysis to prevent excessive cytoplasmic loss. It is specific to several genera of filamentous ascomycetes.
Woronin body
The directed movement of gluconate from outside of a cell, across the plasma membrane and into the cytosol.
gluconate import across plasma membrane
The process by which early and late endosomes undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane.
endosome fission
A SWI/SNF subcomplex that incorporates two mutually exclusive paralogs, GLTSCR1 (glioma tumor suppressor candidate region gene 1) or GLTSCR1L (GLTSCR1-like), BRD9 (bromodomain-containing 9) and the BAF subunits BAF155, BAF60, SS18, BAF53a, and BRG1/BRM.
GBAF complex
The removal of ADP-ribose from ADP-ribosylserine.
peptidyl-serine ADP-deribosylation
The removal of ADP-ribose from ADP-ribosylglutamate.
peptidyl-glutamate ADP-deribosylation
Catalysis of the reaction: (ADP-D-ribosyl)-L-seryl- + H2O = L-seryl- + ADP-ribose.
ADP-ribosylserine hydrolase activity
Catalysis of the reaction: (ADP-D-ribosyl)-L-glutamyl- + H2O = L-glutamyl- + ADP-ribose.
ADP-ribosylglutamate hydrolase activity
The process in which serine is transported from the cytosol into the mitochondrial matrix.
serine import into mitochondrion
The interactions (or cell to cell communication) that occur between the pollen grain (male gametophyte) and the stigmatic tissues of the female sporophyte after the pollen reaches the stigmatic papillae.
pollen-stigma interaction
The interactions (or cell to cell communication) that occur between the male gametophyte (pollen/pollen tube) and the stylar tissues of the female sporophyte.
pollen-style interaction
The activity of recognizing mature outer membrane lipoproteins in the inner membrane and releasing from the inner membrane so that they can be transported across the periplasmic space to their target location, the outer membrane. This function exists in diderm bacteria, mediated by the LolCDE complex.
lipoprotein releasing activity
Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
protein sequestering activity
Binding to a calcium ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
calcium ion sequestering activity
Binding to an iron ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
iron ion sequestering activity
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to the medial cortex.
negative regulation of protein localization to medial cortex
The movement of a lysophospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
lysophospholipid translocation
A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell through the outer membrane.
xenobiotic detoxification by transmembrane export across the cell outer membrane
The movement of an aminophospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
aminophospholipid translocation
The directed movement of heme from inside the vacuole across the vacuolar membrane and into the cytosol.
heme export from vacuole to cytoplasm
Enables the transfer of cyclic-GMP-AMP from one side of a membrane to the other.
cyclic-GMP-AMP transmembrane transporter activity
The directed movement of cyclic-GMP-AMP from outside of a cell, across the plasma membrane and into the cytosol.
cyclic-GMP-AMP transmembrane import across plasma membrane
A ribonucleoprotein granule located in the cytoplasm that is formed by the RNA-binding protein TIS11B and RNA molecules, enriched in membrane protein-encoding mRNAs with multiple AU-rich elements. TIS granules are reticular meshworks intertwined with the endoplasmic reticulum (ER).
TIS granule
A non-stoichiometric protein complex formed by several galectins crosslinking glycosylated ligands to form a dynamic lattice. The galectin lattice modulates receptor kinase signaling and the functionality of membrane receptors, by regulating the diffusion, compartmentalization and endocytosis of plasma membrane glycoproteins and glycolipids.
galectin lattice
An defense response against a bacteria mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.
antibacterial innate immune response
A defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.
antiviral innate immune response
Receiving a signal and transmitting it in a cell to initiate an innate immune response.
innate immune receptor activity
The chemical reactions and pathways resulting in the formation of psilocybin, a psychotropic tryptamine-derived natural product.
psilocybin biosynthetic process
Catalysis of the reaction: tryptamine + reduced acceptor + O2 = 4-hydroxytryptamine + acceptor + H2O.
tryptamine 4-monooxygenase activity
Catalysis of the reaction: 4-hydroxytryptamine + ATP = 4-hydoxytryptamine 4-phosphate + ADP + H+.
4-hydroxytryptamine kinase activity
The morphological, biochemical and genetic changes that induce the differentiation of non-pathogenic parasites into pathogenic metacyclic parasites in the Trypanosomatidae species. The pathogenic parasites are known as metacyclic trypomastigotes in Trypanosoma and metacyclic promastigotes in Leishmania.
metacyclogenesis
Catalysis of the reaction: (1'S)-averantin + NADP+ = norsolorinic acid + NADPH.
norsolorinic acid ketoreductase activity
Catalyzes the reaction: (1'S)-averantin +  + O2 = (1'S,5'S)-5'-hydroxyaverantin +  + H2O. Involved in aflatoxin biosynthesis.
averantin hydroxylase activity
Catalyzes the reaction: (1'S,5'S)-hydroxyaverantin + NAD+ = 5'-oxoaverantin + NADH.
5'-hydroxyaverantin dehydrogenase activity
Catalyzes the reactions: versiconal hemiacetal acetate + H2O = versiconal + acetate, as well as versiconol acetate + H2O = versiconol + acetate.
versiconal hemiacetal acetate esterase activity
Catalyzes the reaction: versicolorin B + NADPH + O2 = versicolorin A + NADP+ + 2 H2O. Uses heme-thiolate as a co-factor. Involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus.
versicolorin B desaturase activity
Catalyzes the reaction: 8-O-methylsterigmatocystin + 2  + 2 O2 = aflatoxin B + 2  + H2O + methanol + CO2. Produces both aflatoxin B(1) and aflatoxin B(2).
aflatoxin B synthase activity
A microtubule-based process in which chromosomes migrate as a result of rapid spindle pole body (SPB) and centrosome oscillations during mitotic interphase.
spindle pole body-led chromosome movement during mitotic interphase
The directed movement of L-alanine from inside of a cell, across the plasma membrane and into the extracellular region.
L-alanine export across the plasma membrane
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-alanine(in) = H+(in) + L-alanine(out).
L-alanine:proton antiporter activity
Any process that activates or increases the frequency, rate or extent of mRNA alternative polyadenylation.
positive regulation of mRNA alternative polyadenylation
The directed movement of galactose from outside of a cell, across the plasma membrane and into the cytosol.
galactose import across plasma membrane
Any process that activates or increases the frequency, rate or extent of a chromosome passenger complex localization to kinetochore.
positive regulation of chromosome passenger complex localization to kinetochore
Catalysis of the hydrolysis of phosphodiester bonds in 5'OH-RNA according to the reaction 5'OH-RNA + H20 = 5'OH-NpN (dinucleotide) + 5'P-RNA.
5'-hydroxyl dinucleotide hydrolase activity
Any process that increases the frequency, rate or extent of protein localization to a meiotic spindle pole body.
positive regulation of protein localization to meiotic spindle pole body
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to a meiotic spindle pole body.
negative regulation of protein localization to meiotic spindle pole body
The covalent attachment of a stearoyl group to an amino acid in a protein.
protein stearoylation
Catalysis of the transfer of a stearoyl (systematic name, octadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: octadecanoyl-CoA + L-cysteinyl- = CoA + S-octadecanoyl-L-cysteinyl-.
protein-cysteine S-stearoyltransferase activity
Catalysis of the transfer of an oleoyl (systematic name, (9Z)-octadecenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: (9Z)-octadecenoyl-CoA + L-cysteinyl- = CoA + S-(9Z-octadecenoyl)-L-cysteinyl-.
protein-cysteine S-oleoyltransferase activity
Catalysis of the transfer of an arachidonoyl (systematic name, (5Z,8Z,11Z,14Z)-eicosatetraenoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: in the reaction: (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + L-cysteinyl- = CoA + S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-cysteinyl-.
protein-cysteine S-arachidonoyltransferase activity
Binding to hydrogen peroxide (H2O2) and eliciting a change in the protein's activity in response to the intracellular level of that small molecule.
peroxide sensor activity
The process of targeting specific proteins to the Golgi apparatus. Usually requires an organelle-specific protein sequence motif or a protein modification (for example a palmitoylation).
protein targeting to Golgi apparatus
A secreted multiprotein complex composed of 4 proteins, regulating group size during aggregation in cooperative development. An example of this complex is found in Dictyostelium discoideum.
counting factor complex
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a Gram-positive bacterium.
response to Gram-positive bacterium
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a Gram-negative bacterium.
response to Gram-negative bacterium
The organization of chromatin into heterochromatin at the pericentric region of a chromosome.
pericentric heterochromatin organization
The directed movement of iron sulfur clusters from inside the mitochondrion into the cytosol by crossing the inner mitochondrial membrane.
iron-sulfur cluster export from the mitochondrion
The region directly beneath the plasma membrane at the cell tip at which no growth takes place.
cell cortex of non-growing cell tip
A biosynthetic process that results in the formation of ergothioneine from histidine via a set of steps including the hercynylcysteine sulfoxide synthase reaction, which converts N-alpha,N-alpha,N-alpha-trimethyl-L-histidine directly to hercynylcysteine sulfoxide.
ergothioneine biosynthesis from histidine via hercynylcysteine sulfoxide synthase
Binding to and responding, e.g. by conformational change, to changes in the cellular level of iron.
iron sensor activity
The directed movement of 5-aminolevulinic acid from outside of a cell, across the plasma membrane and into the cytosol.
5-aminolevulinic acid import across plasma membrane
Enables the transfer of 5-aminolevulinic acid from one side of a membrane to the other.
5-aminolevulinic acid transmembrane transporter activity
Binding to a zinc ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
zinc ion sequestering activity
Binding specifically to heme to deliver it to a transport vesicle.
heme receptor activity
A fatty acid beta-oxidation pathway acting on a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. The partway stars with the conversion of an acyl-CoA to a trans-2-enoyl-CoA, catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
very long-chain fatty acid beta-oxidation
A vesicular organelle that forms on retraction fibers behind migrating cells and mediates the release of cytoplasmic contents during cell migration.
migrasome