NothingMuch/GO-Terms huggingface dataset:
A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway.
VRK3/VHR/ERK complex
A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.
manchette
A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine.
homodimeric serine palmitoyltransferase complex
An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity.
5-lipoxygenase complex
A dimeric protein complex having creatine kinase activity.
cytosolic creatine kinase complex
An octomeric protein complex having creatine kinase activity.
mitochondrial creatine kinase complex
A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon.
translation reinitiation
The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation.
IRES-dependent translational initiation of linear mRNA
The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes.
hepatocyte cell migration
Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala).
Ser-tRNA(Ala) hydrolase activity
A homodimeric protein complex having xanthine dehydrogenase activity.
xanthine dehydrogenase complex
The somatic process that results in the generation of sequence diversity of the DSCAM-based immune receptors of insects.
somatic diversification of DSCAM-based immune receptors
The somatic process that results in the generation of sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish.
somatic diversification of variable lymphocyte receptors of jawless fish
The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation.
proteolysis by cytosolic proteases associated with antigen processing and presentation
Any process of the innate immune response that takes place in the mucosal tissues.
innate immune response in mucosa
The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal.
detection of oomycetes
The series of events in which an unfolded protein stimulus is received and converted into a molecular signal.
detection of unfolded protein
The series of events in which a misfolded protein stimulus is received and converted into a molecular signal.
detection of misfolded protein
Reactions triggered in response to the presence of a parasitic plant that act to protect an organism.
defense response to parasitic plant
The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal.
detection of parasitic plant
The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus.
mucosal lymphocyte homeostasis
The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell.
follicular dendritic cell differentiation
The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor.
natural killer cell progenitor differentiation
The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal.
detection of tumor cell
Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism.
defense response to tumor cell
An immune response taking place in the brain or nervous system.
immune response in brain or nervous system
An immune response taking place in the liver.
hepatic immune response
Tolerance induction taking place in the Peyer's patches.
tolerance induction in Peyer's patch
The movement of a Langerhans cell in response to an external stimulus.
Langerhans cell chemotaxis
The movement of a plasmacytoid dendritic cell in response to an external stimulus.
plasmacytoid dendritic cell chemotaxis
Tolerance induction taking place in the urogenital tract.
tolerance induction in urogenital tract
Tolerance induction to nonself antigens in the central lymphoid organs.
central tolerance induction to nonself antigen
Tolerance induction to nonself antigens in the periphery.
peripheral tolerance induction to nonself antigen
Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues.
peripheral tolerance induction to self antigen
The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.
peptide antigen assembly with MHC class Ib protein complex
The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family.
lipid antigen assembly with MHC class Ib protein complex
The directed movement of a lipid antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
lipid antigen transport
The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation.
proteasomal proteolysis associated with antigen processing and presentation
The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules.
peptide antigen assembly with MHC class I protein complex
The binding of a peptide to the antigen binding groove of an MHC class II protein complex.
peptide antigen assembly with MHC class II protein complex
Tolerance induction in the central lymphoid organs directed at self antigens.
central tolerance induction to self antigen
The regulated release of histamine by a platelet or group of platelets.
histamine secretion by platelet
The regulated release of histamine by a basophil or group of basophils.
histamine secretion by basophil
An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
type I hypersensitivity mediated by mast cells
An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.
type I hypersensitivity mediated by basophils
The process that results in the generation of sequence diversity of the FREP-based immune receptors of snails.
somatic diversification of FREP-based immune receptors
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.
thrombocyte differentiation
The movement of a basophil in response to an external stimulus.
basophil chemotaxis
Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis.
antigen processing and presentation following phagocytosis
Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis.
antigen processing and presentation following macropinocytosis
The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response.
innate immune response-inhibiting signal transduction
The chemical reactions and pathways involved in the biosynthesis of archaeosine, an archaea-specific modified base found at position 15 in the D-loop of certain archaeal tRNAs.
archaeosine-tRNA biosynthetic process
The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor.
trabecular meshwork development
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
response to ischemia
The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move.
tendon sheath development
The chemical reactions and pathways resulting in the formation of the peptide hormone bradykinin.
bradykinin biosynthetic process
The processes whereby a uridine residue in a tRNA is converted to 4-thiouridine. Typically 4-thiouridine is found at position 8, in many transfer RNAs.
tRNA 4-thiouridine biosynthesis
The process whereby a guanine residue in a transfer RNA is methylated twice at the N2 position.
tRNA m2,2-guanine biosynthesis
The process whereby a uridine in a transfer RNA is converted to dihydrouridine.
tRNA dihydrouridine synthesis
Catalysis of the reaction: an N-acyl-sphingoid base + CDP-ethanolamine = an N-acyl-sphingoid 1-phosphoethanolamine + CMP + H+.
ceramide phosphoethanolamine synthase activity
Catalysis of the reaction leukotriene C(4) + H2O= leukotriene D(4) + L-glutamate.
leukotriene-C(4) hydrolase
Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate.
5'-deoxynucleotidase activity
The flow of lymph through the body of an animal.
lymph circulation
The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris.
central nervous system control of baroreceptor feedback
The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal.
baroreceptor detection of increased arterial stretch
The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal.
baroreceptor detection of decreased arterial stretch
The process in which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.
circadian regulation of systemic arterial blood pressure by hormone
The process in which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen.
regulation of systemic arterial blood pressure by local renal renin-angiotensin
The process in which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus.
tubuloglomerular feedback
Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process whereby blood is filtered by the glomerulus into the renal tubule.
positive regulation of glomerular filtration
The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry.
detection of nodal flow
The establishment of the lateral mesoderm with respect to the left and right halves.
determination of left/right asymmetry in lateral mesoderm
The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation.
neural crest cell migration involved in heart formation
The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.
outflow tract septum morphogenesis
The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.
membranous septum morphogenesis
The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum.
muscular septum morphogenesis
Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold.
closure of embryonic heart tube
The process in which the anatomical structures of veins of the heart are generated and organized.
coronary vein morphogenesis
The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
aortic valve formation
The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
coronary sinus valve formation
The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
mitral valve formation
The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
pulmonary valve formation
The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
tricuspid valve formation
The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.
ventriculo bulbo valve formation
A transition where an endocardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the heart septum.
endocardial cushion to mesenchymal transition involved in heart chamber septation
A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the shaping of the coronary vasculature.
epithelial to mesenchymal transition involved in coronary vasculature morphogenesis
A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will give rise to the cardiac skeleton.
endocardial cushion to mesenchymal transition involved in cardiac skeleton development
The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts.
cardiac left atrium formation
The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts.
cardiac right atrium formation
The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts.
cardiac left ventricle formation
The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts.
cardiac right ventricle formation
The process in which the anatomical structures of cardiac left ventricular compact myocardium are generated and organized.
left ventricular compact myocardium morphogenesis
The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized.
left ventricular trabecular myocardium morphogenesis
The process in which the anatomical structures of the right ventricular compact myocardium are generated and organized.
right ventricular compact myocardium morphogenesis
The process in which the anatomical structures of the right ventricular myocardium are generated and organized.
right ventricular trabecular myocardium morphogenesis
The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart.
bulbus arteriosus formation
The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.
sinus venosus formation
The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk.
conus arteriosus formation
The morphogenic growth in which the chambers of the heart expand in size, contributing to their shaping.
cardiac chamber ballooning
The morphogenetic growth in which the left ventricle grows expanding its external boundary.
circumferential growth involved in left ventricle morphogenesis
The morphogenic growth in which the right ventricle grows along a radial axis.
radial growth involved in right ventricle morphogenesis
The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart.
post-embryonic cardiac muscle cell growth involved in heart morphogenesis
The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle.
heart capillary growth
Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.
positive regulation of cell proliferation involved in heart valve morphogenesis
Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.
negative regulation of cell proliferation involved in heart valve morphogenesis
The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of an endocardial precursor cell. A endocardial precursor cell is a cell that has been committed to a endocardial cell fate, but will undergo further cell divisions rather than terminally differentiate.
endocardial precursor cell differentiation
The orderly movement of a cardioblast toward the head and laterally to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
cardioblast anterior-lateral migration
The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart.
endocardial progenitor cell migration to the midline involved in heart field formation
The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.
cell migration involved in endocardial cushion formation
The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping.
endocardial cushion fusion
The progression of the ventricular septum intermedium over time, from its formation to the mature structure.
ventricular septum intermedium development
The developmental process in which a ventricular septum intermedium is generated and organized.
ventricular septum intermedium morphogenesis
The process in which anatomical structure of an atrial septum primum is generated and organized.
atrial septum primum morphogenesis
The process in which anatomical structure of an atrial septum secundum is generated and organized.
atrial septum secundum morphogenesis
The process in which anatomical structure of an atrial septum intermedium is generated and organized.
atrial septum intermedium morphogenesis
The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve.
heart valve cell differentiation
The morphogenetic process in which the aorta inserts between the atrioventricular valves, contributing to the shaping of the heart.
heart wedging
The morphogenetic process in which the myocardium bends along a linear axis and contributes to the process of heart jogging.
myocardial epithelial involution involved in heart jogging
The orderly movement of a cell of the myocardium from one site to another that will contribute to heart jogging.
cell migration involved in heart jogging
The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment.
cardioblast migration to the midline involved in heart rudiment formation
The inward folding of myocardial tissue derived from the right half of the heart rudiment that will form the future ventral part of the heart tube.
heart rudiment involution
The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.
pancreatic PP cell development
The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.
pancreatic A cell fate commitment
The commitment of a cell to a pancreatic D cell fate and its capacity to differentiate into a pancreatic D cell. A delta cell is a cell of the pancreas that produces somatostatin.
pancreatic D cell fate commitment
The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.
pancreatic PP cell fate commitment
Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
positive regulation of extracellular matrix constituent secretion
Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.
negative regulation of extracellular matrix constituent secretion