NothingMuch/GO-Terms huggingface dataset:
Any process that stops, prevents or reduces the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one).
negative regulation of mitotic spindle formation (spindle phase one)
Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic prophase (spindle phase one).
positive regulation of mitotic spindle formation (spindle phase one)
Any process that stops, prevents or reduces the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B (spindle phase three).
negative regulation of mitotic spindle elongation (spindle phase three)
Any process that activates or increases the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle during mitotic anaphase B (spindle phase three).
positive regulation of mitotic spindle elongation (spindle phase three)
A cytoplasmic vesicle which contains two urothelial plaques and can deliver these plaques to the apical plasma membrane of urothelial superficial (umbrella) cells. It can also be formed by endocytosis of apical plasma membrane during contractions of the urinary bladder.
fusiform vesicle
A narrow rim of non-thickened membrane in between urothelial plaques in apical plasma membrane.
hinge region between urothelial plaques of apical plasma membrane
Any process that stops, prevents or reduces the frequency, rate or extent of glutamatergic neuron differentiation.
negative regulation of glutamatergic neuron differentiation
Any process that activates or increases the frequency, rate or extent of glutamatergic neuron differentiation.
positive regulation of glutamatergic neuron differentiation
The transport of phospholipids between membranes in which a phospholipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane.
intermembrane phospholipid transfer
The transport of sterols between membranes in which a sterol molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs).
intermembrane sterol transfer
The transport of sphingolipids between membranes in which a sphingolipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. This process does not require metabolic energy and can be either spontaneous or mediated by lipid transfer proteins (LTPs).
intermembrane sphingolipid transfer
Binding to somatostatin, a polypeptide hormone involved in regulating pancreatic alpha and pancreatic beta cells and controlling growth hormone secretion as well as many other functions. Somatostatin is produced by several cell types including pancreatic delta cells. There are several different mature forms of somatostatin.
somatostatin binding
Any process that activates or increases the frequency of cilium beating involved in ciliary motility.
positive regulation of cilium beat frequency involved in ciliary motility
Any process that activates or increases the frequency, rate or extent of macrophage proliferation.
positive regulation of macrophage proliferation
Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage proliferation.
negative regulation of macrophage proliferation
The shaft comprises the majority of the length of the stereocilium. This region is notable for the extreme stability of actin filaments, which are highly crosslinked into a parallel bundle.
stereocilium shaft
The organization process that preserves a stereocilium in a stable functional or structural state.
stereocilium maintenance
Any process that activates or increases the frequency, rate or extent of protein localization to a medial cortical node.
positive regulation of protein localization to medial cortical node
Catalysis of the reaction: adenosine in U6 snRNA + S-adenosyl-L-methionine = H+ + N(6)-methyladenosine in U6 snRNA + S-adenosyl-L-homocysteine.
U6 snRNA (adenine-(43)-N(6))-methyltransferase activity
The posttranscriptional N6-methylation of an adenine residue in an snRNA molecule.
snRNA (adenine-N6)-methylation
Catalysis of the reaction: UDP-D-xylose + D-ribitol 5-phosphate-R = UDP + beta1,4-xylosyl-D-ribitol 5-phosphate-R.
ribitol beta-1,4-xylosyltransferase activity
Any process that decreases the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum.
negative regulation of gastric emptying
Any process that increases the frequency, rate or extent of any gastric emptying process, the process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum.
positive regulation of gastric emptying
A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the distal part of the pylorus between the pyloric antrum and the pyloric sphincter.
pyloric canal smooth muscle contraction
A process in which force is generated within gastric smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the narrowest part of the pylorus that separates the stomach from the duodenum.
pyloric sphincter smooth muscle contraction
Any process that increases the frequency, rate or extent of any stomach fundus smooth muscle contraction.
positive regulation of stomach fundus smooth muscle contraction
Any process that decreases the frequency, rate or extent of any stomach fundus smooth muscle contraction.
negative regulation of stomach fundus smooth muscle contraction
Any process that increases the frequency, rate or extent of any pyloric antrum smooth muscle contraction.
positive regulation of pyloric antrum smooth muscle contraction
Any process that decreases the frequency, rate or extent of any pyloric antrum smooth muscle contraction.
negative regulation of pyloric antrum smooth muscle contraction
Any process that activates or increases the frequency, rate or extent of endocardial cushion cell differentiation.
positive regulation of endocardial cushion cell differentiation
Any process that stops, prevents, or reduces the frequency, rate or extent of endocardial cushion cell differentiation.
negative regulation of endocardial cushion cell differentiation
A subcompartment of the rough endoplasmic reticulum consisting of lumenal expansion into a flattened, disc-shaped cavity.
rough endoplasmic reticulum cisterna
The assembly of a filopodium, a thin, stiff protrusion extended by the endothelial tip cell of a vascular sprout.
endothelial tip cell filopodium assembly
Catalysis of the reaction: Acetyl-CoA + -L-lysine = CoA + -N(6)-acetyl-L-lysine.
crotonyl-CoA hydratase activity
Any process that stops or reduces the rate of crotonylation of a lysine residue in a protein.
negative regulation of peptidyl-lysine crotonylation
A cellular structure that is the site of a developing centriole, which will become a microtubule organizing center. During the canonical pathway of centriole duplication that occurs during the cell division cycle, procentrioles grow at the proximal ends of both mother and daughter centrioles. In the newly divided cells, the original mother and daughter centrioles become mother centrioles while the procentrioles become the new daughter centrioles. Procentrioles can also arise from de novo pathways that occur in multiciliated cells. In ciliated epithelial cells, numerous procentrioles arise form electron dense material referred to as fibrous granules and deuterosomes. The pathway of procentriole formation in multiciliated protists appears to be similar to that in mammalian multiciliated epithelium. In sperm of primitive land plants, multiple procentrioles are formed from a blepharoplast giving rise to multicilated sperm cells.
procentriole
A protein complex that acts as a chaperone or scaffold for centriolar proteins during the maturation of the procentriole. Some of its members may become integrated into the growing centriole. Examples are the CPAP(CENPJ)-STIL complex, CEP192-PLK4 complex or CEP152-PLK4 complex in vertebrates.
procentriole replication complex
The rotor complex of the bacterial-type flagellum consists of a membrane-anchored ring and the motor switch complex, which participates in the conversion of proton/Na+ energy into the mechanical work of rotation and controls the direction of flagellar rotation.
bacterial-type flagellum rotor complex
The directed movement of UDP-glucose from cytosol to endoplasmic reticulum.
UDP-glucose transmembrane transport into endoplasmic reticulum
A heteroheptameric, nuclear protein complex composed of Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Lsm8, or orthologs thereof, that selectively binds to snRNAs, in particular U6 or U6atac snRNAs, and also to unspliced transcripts localized within the nucleus.
Lsm2-8 complex
The formation of mature glucagon by proteolysis of the precursor proglucagon.
glucagon processing
A mobile transmembrane junction at the tip of the flagellum of some kinetoplastid species linking the tip of a new growing flagellum to an older flagellum.
flagella connector
A protein complex responsible for the catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue.
PNGase complex
Any process that modulates the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity.
regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
Catalysis of the reaction: A -L-cysteine + O2 + 2 a thiol = a -3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O.
formylglycine-generating oxidase activity
Binding to an outer dynein arm in the presence of calcium.
calcium-dependent outer dynein arm binding
Binding to a carbohydrate in the presence of calcium.
calcium-dependent carbohydrate binding
Any process that stops, prevents or reduces the frequency, rate or extent of ERBB4 signaling pathway.
negative regulation of ERBB4 signaling pathway
The physiological and developmental changes that occur in a conidium or asexual spore following release from dormancy up to the earliest signs of development such as swelling of conidia, adhesion and nuclear decondensation followed by hyphal growth several hours later. In many genera of plant pathogenic fungi (e.g. Magnaporthe, Colletotrichum, Ustilago), swelling of the hyphal tips to form appressorium, metabolic activities including respiration, RNA and protein synthesis and trehalose breakdown and changes in cell wall composition can be detected in conidium germination.
conidium germination
The process of producing fruiting body precursors, called protoperithecia. Protoperitheicium is a spherical structure that is formed in the sexual phase of ascomycetous fungi such as Neurospora crassa and Sordaria macrospora. Protoperithecium is formed by the enveloping of ascogonia cells by sterile hyphae and it develops into perithecium.
protoperithecium formation
Any process that activates or increases the frequency, rate or extent of the torso signaling pathway.
positive regulation of torso signaling pathway
Any process that stops, prevents, or reduces the frequency, rate or extent of the torso signaling pathway.
negative regulation of torso signaling pathway
The disaggregation of an adherens junction into its constituent components. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
adherens junction disassembly
Any process that activates or increases the frequency, rate or extent of disaggregation of a focal adhesion into its constituent components.
positive regulation of focal adhesion disassembly
Any process that stops, prevents, or reduces the frequency, rate or extent of a focal adhesion into its constituent components.
negative regulation of focal adhesion disassembly
Any process that activates or increases the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.
positive regulation of bile acid secretion
Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue.
negative regulation of bile acid secretion
Any process that activates or increases the frequency, rate or extent of anther dehiscence.
positive regulation of anther dehiscence
Any process that stops, prevents, or reduces the frequency, rate or extent of anther dehiscence.
negative regulation of anther dehiscence
Any process that increases the size of an imaginal disc-derived wing.
positive regulation of imaginal disc-derived wing size
The outer segment of a vertebrate cone photoreceptor that contains membrane discs that are contiguous with the ciliary membrane and containing opsin photoreceptor proteins.
cone photoreceptor outer segment
Stack of disc membranes located inside a cone photoreceptor outer segment, and containing densely packed molecules of opsin photoreceptor proteins that traverse the lipid bilayer. Cone disc membranes arise as evaginations of the ciliary membrane during the development of the cone outer segment and remain contiguous with the ciliary membrane.
cone photoreceptor disc membrane
Stack of disc membranes located inside a rod photoreceptor outer segment, and containing densely packed molecules of rhodopsin photoreceptor proteins that traverse the lipid bilayer. It is thought that rod disc membranes arise as evaginations of the ciliary membrane near the base of the outer segment, which then become completely separated from the ciliary membrane, during the development of the rod outer segment.
rod photoreceptor disc membrane
The volume enclosed by the membrane of a rod photoreceptor cell disc membrane.
rod photoreceptor disc lumen
Catalysis of the reaction: methylcytosine + L-ascorbate + O2 = 5-glyceryl-methylcytosine + glyoxylate + CO2.
methylcytosine to 5-glyceryl-methylcytosine dioxygenase activity
The process of selecting and or marking the position where endocytosis will occur.
endocytosis, site selection
Cone telodendria are projections that originate from the cone pedicle and form gap junctions with other photoreceptors within the outer plexiform layer of the retina.
cone telodendria
Rod telodendria are projections that originate from the rod pedicle and form gap junctions with other photoreceptors within the outer plexiform layer of the retina.
rod telodendria
Fusion of the membrane of proacrosomal vesicle with the membrane of another proacrosomal vesicle to form the acrosome.
proacrosomal vesicle fusion
A quorum sensing process that is modulated by some interaction with a host cell or organism.
host interaction involved in quorum sensing
Any process involved in maintaining the planar beating pattern of ciliary movement pattern. Connection between the outer doublets and the central pair via the radial spokes constrains ciliary movement to the planar beating pattern. Cilia that lack this connection, such as those in the embryonic node or Kupfer's vesicle, display radial movement.
maintenance of ciliary planar beating movement pattern
Any process that modulates the frequency, rate or extent of blastocyst development.
regulation of blastocyst development
Binds to and increases the activity of a recombinase.
recombinase activator activity
The carbohydrate rich layer at the outermost periphery of a sperm cell.
sperm glycocalyx
The carbohydrate rich layer at the outermost periphery of a platelet.
platelet glycocalyx
The acetylation of peptidyl-threonine to form peptidyl-O-acetyl-L-threonine.
peptidyl-threonine O-acetylation
A rod-shaped protein complex containing Centrin4 protein that flanks the flagellum attachment zone (FAZ) filament and the quartet microtubules.
ciliary centrin arm
Any process that stops, prevents or reduces the frequency, rate or extent of selective degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein.
negative regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts
Any process that activates or increases the frequency, rate or extent of degradation of meiosis-specific nuclear transcribed transcripts during vegetative growth, by a mechanism that requires determinant of selective removal (DSR) sequences in the targeted mRNAs and involves a YTH family protein.
positive regulation of nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts
A lipid bilayer that surrounds an autolysosome, a single-membrane-bounded vesicle in which endogenous cellular material is degraded.
autolysosome membrane
The volume that is enclosed within the autolysosome single-membrane.
autolysosome lumen
Binding to a protein serine/threonine kinase.
protein serine/threonine kinase binding
Catalysis of the reaction: L-glutaminyl- + serotonin = 5-serotonyl-L-glutamyl- + NH4(+).
histone serotonyltransferase activity
Catalysis of the reaction: dopamine + L-glutaminyl- = 5-dopaminyl-L-glutamyl- + NH4(+).
histone dopaminyltransferase activity
Catalysis of the reaction: (R)-noradrenaline + L-glutaminyl- = 5-(R)-noradrenalinyl-L-glutamyl- + NH4(+).
peptide noradrenalinyltransferase activity
Catalysis of the reaction: histamine + L-glutaminyl- = 5-histaminyl-L-glutamyl-.
peptide histaminyltransferase activity
Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity detected by melanopsin-expressing eye cells.
visually-mediated background adaptation
Any process in which an organism changes its pigmentation (lightening in response to a brighter environment or darkening in response to a dimmer environment) in response to a change in light intensity detected by light sensitive cells in the integument.
integument-mediated background adaptation
An extended membranous thread which firmly connects the plasma membrane to the cell wall during plasmolysis such that the plasma membrane does not separate from the cell wall completely.
Hechtian strand
The morphological, biochemical and genetic changes that induce the differentiation of metacyclic parasites into amastigotes in some of the Trypanosomatidae species such as Leishmania parasites and Trypanosoma cruzi. This process occurs inside the cells of the mammalian hosts, particularly in macrophages and other phagocytic cells for Leishmania parasites.
amastigogenesis
Any process that stops, prevents, or reduces the frequency, rate or extent of oocyte karyosome formation, the chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome.
negative regulation of oocyte karyosome formation
Any process that activates or increases the frequency, rate or extent of oocyte karyosome formation, the chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome.
positive regulation of oocyte karyosome formation
The assembly and organization of the sperm mitochondrial sheath, the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum.
sperm mitochondrial sheath assembly
The use of external chemical cues called pheromones to send social and sexual information between members of the same species, leading to specific behavioral responses. Pheromones may be detected by two olfactory sensory circuits, the main olfactory pathway and the vomeronasal system.
olfactory sociosexual communication
The process in which one or more ubiquitin groups are added to a lipid.
lipid ubiquitination
The morphological, biochemical and genetic changes that induce the differentiation of bloodstream form trypomastigotes into procyclic trypomastigotes in some of the Trypanosomatidae species such as Trypanosoma brucei. This process occurs inside the midgut of the tsetse fly vectors in T. brucei.
procyclogenesis
Binding to a NuRD complex.
NuRD complex binding
A telopode is a plasma membrane bounded cell projection that is present on a telocyte and is tens to hundreds of microns long. Telopodes form a labyrinthine system communicating through gap junctions.
telopode
Catalytic activity that acts to transfer a methyl group to a DNA molecule, driven by ATP hydrolysis.
ATP-dependent DNA (cytosine-5-)-methyltransferase activity
The developmental process pertaining to the initial formation of an endothelial tube.
endothelial tube formation
The short portion of the radial spoke 1 (RS1) that is directly anchored to the A microtubule of an axonemal microtubule doublet.
radial spoke base 1
The short portion of the radial spoke 2 (RS2) that is directly anchored to the A microtubule of an axonemal microtubule doublet.
radial spoke base 2
The short portion of the radial spoke 3 (RS3 )that is directly anchored to the A microtubule of an axonemal microtubule doublet.
radial spoke base 3
The radial spoke neck is a complex that connects the spoke stalk to the head.
radial spoke neck
Catalysis of the reaction: L-methionyl- + NADPH + O2 + H+ = L-methionyl-(R)-S-oxide- + NADP+ + H2O.
F-actin monooxygenase activity
Catalysis of the reaction: an (omega-1)-ethyl medium-chain fatty acid + O2 + reduced  = an (omega-1)-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized
medium-chain fatty acid omega-1 hydroxylase activity
Catalysis of the reaction: L-lysyl79- + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl79- + S-adenosyl-L-homocysteine.
histone H3K79 monomethyltransferase activity
Catalysis of the reaction: L-lysyl79- + 2 S-adenosyl-L-methionine = 2H+ + N6,N6-methyl-L-lysyl79- + 2 S-adenosyl-L-homocysteine.
histone H3K79 dimethyltransferase activity
Catalysis of the reaction: (R)-glycerate + NADP+ = 3-hydroxypyruvate + NADPH + H+.
hydroxypyruvate reductase (NADPH) activity
Catalysis of the reaction: a 3'-hydro-2'-hydroxy-beta-oxodihydrochalcone + UDP-alpha-D-glucose = a 3'-(beta-D-glucopyranosyl)-2'-hydroxy-beta-oxodihydrochalcone + H+ + UDP.
2-hydroxyflavanone C-glucosyltransferase activity
Catalysis of the reaction: a diacylglycerol + H2O = a fatty acid + a monoacylglycerol + H+.
diacylglycerol lipase activity
Catalysis of the reaction: acetyl-CoA + N-terminal L-methionyl- = CoA + H+ + N-terminal N(alpha)-acetyl-L-methionyl-.
peptide-methionine-alpha-N-acetyltransferase activity
Catalysis of the reaction: acetyl-CoA + N-terminal L-methionyl- = CoA + H+ + N-terminal N(alpha)-acetyl-L-methionyl-. The N-terminus of both alpha- and beta-tubulin are acetylated.
tubulin N-terminal N-acetyltransferase activity
Catalysis of the reaction: a 1,2-saturated fatty acid + 2 Fe(II)- + 2 H+ + O2 = a (R)-2-hydroxy fatty acid + 2 Fe(III)- + H2O. Note that the substrate is a free fatty acid, not a fatty acyl chain within a sphingolipid.
free fatty acid 2-hydroxylase activity
Catalysis of the reaction: an N-(1,2 saturated acyl)-(4R)-hydroxysphinganine + 2 Fe(II)- + 2 H+ + O2 = an N-(2R-hydroxyacyl)-4R-hydroxysphinganine + 2 Fe(III)- + H2O.
4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase activity
Catalysis of the reaction: a short-chain 2,3-saturated fatty acyl-CoA + O2 = a short-chain (2E)-enoyl-CoA + H2O2.
short-chain fatty acyl-CoA oxidase activity
Catalysis of the reaction: a medium-chain 2,3-saturated fatty acyl-CoA + O2 = a medium-chain (2E)-enoyl-CoA + H2O2.
medium-chain fatty acyl-CoA oxidase activity