NothingMuch/GO-Terms huggingface dataset:
The series of molecular signals initiated by glutamate binding to an AMPA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription.
AMPA selective glutamate receptor signaling pathway
The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
extrinsic component of postsynaptic early endosome membrane
The component of the postsynaptic recycling endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
extrinsic component of postsynaptic recycling endosome membrane
The component of the presynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
extrinsic component of presynaptic endosome membrane
The circularization of a viral genome following infection of a host cell. This is common amongst bacterial viruses to protect the viral genome ends from nucleases, to convert the linear genome to an integrative precursor or to give rise to the replicative form of the genome. It can be mediated by covalent closure of the DNA sticky ends, recombinaison between redundant terminal sequences or via the binding of a protein at the viral DNA extremities.
viral genome circularization
The volume enclosed by a neuronal dense core vesicle membrane.
neuronal dense core vesicle lumen
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle.
neuronal dense core vesicle organization
The catabolic breakdown of the DNA of a host chromosome by a virus. This occurs during infection of bacteria by some phages. It frees up a large pool of nucleoside 5'-triphophates for use in viral DNA synthesis.
degradation of host chromosome by virus
The volume enclosed by the membranes of the perinuclear endoplasmic reticulum.
perinuclear endoplasmic reticulum lumen
The volume enclosed by the membranes of the cortical endoplasmic reticulum.
cortical endoplasmic reticulum lumen
The movement of a ceramide molecule from one leaflet of a membrane bilayer to the opposite leaflet.
ceramide translocation
The initial, indirect interaction between a transport vesicle membrane and the membrane of the Golgi. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion.
vesicle tethering to Golgi
Formation of a macromolecular complex during clathrin-dependent endocytosis that connects the assembling clathrin coat to the proteins and/or lipoproteins to be transported in an endocytic vesicle. This complex includes a receptor and an adaptor protein that links the receptor to the clathrin coat.
cargo loading involved in clathrin-dependent endocytosis
The initial, indirect interaction between a transport vesicle membrane and the membrane of the endoplasmic reticulum. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior fusion.
vesicle tethering to endoplasmic reticulum
The process whereby a filamentous phage particle is released from a bacterial host cell via a concerted mechanism of assembly and secretion. Neosynthesized virions are coordinately exported as they are assembled at the cell surface in a secretory process that leaves the host cell fully viable. Non-capsid proteins form structures that facilitate translocation through the inner membrane and outer membranes. A viral single-stranded DNA binding protein coats progeny viral DNA molecules to generate the intracellular precursor for assembly of phage particles as they are extruded through the membranes of the bacterial host. The structural proteins of the virus are anchored in the inner membrane before their incorporation into the phage particle. As assembly proceeds, the phage genome traverses the inner and outer membranes until the entire DNA molecule has been coated and extruded.
viral extrusion
A defense process that protects an organism from invading foreign RNA.
clearance of foreign intracellular RNA
A defense response of that serves to clear host cells of foreign DNA and RNA. It has three distinct stage: acquisition of foreign DNA by integration into CRISPR loci in the host chromosome, CRISPR RNA (crRNA) biogenesis, and target interference. CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeat, which describes the nature of the loci.
CRISPR-cas system
The process that results in the assembly of clathrin triskelia into a clathrin cage during endocytosis. Clathrin is recruited to the plasma membrane via interaction with scaffolding proteins that bridge between clathtin and cell surface receptors. Clathrin coat formation is concomittant with coated pit formation leading to endocytic vesicle formation.
clathrin coat assembly involved in endocytosis
The membrane scission process that is the final step in the formation of a clathrin-coated endocytic vesicle: separation from the plasma membrane.
vesicle scission involved in clathrin-mediated endocytosis
The initial, indirect interaction between a synaptic vesicle membrane and a the preseynaptic membrane active zone. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. This process is distinct from and prior to synaptic vesicle priming and fusion.
synaptic vesicle tethering involved in synaptic vesicle exocytosis
A microtubule bundle that undergoes changes in length, and in which microtubule sliding takes place.
dynamic microtubule bundle
DNA-binding activity that is dependent on binding to a histone.
histone-dependent DNA binding
A protein complex that is involved in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors.
BORC complex
An amorphous cytoskeletal structure consisting of aggregated actin filaments and associated proteins (including fibrin and capping protein) in which there is little or no actin filament turnover. In yeast (S. pombe and S. cerevisiae) these are found only in quiescent cells and are thought to serve as a reserve store of actin.
actin body
Modulation of synaptic transmission by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide.
retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission
A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
postsynaptic density, intracellular component
The giant, cup-shaped axon terminal of a vestibular afferent neuron, serving as a post-synaptic contact to a type I hair cell.
vestibular calyx terminal
Any G-protein gated potassium channel activity that is involved regulation of postsynaptic membrane potential.
G-protein gated potassium channel activity involved in regulation of postsynaptic membrane potential
The transport of a protein to the cortex of the cell tip, driven by polymerization of a microtubule to which the protein is attached.
microtubule polymerization based protein transport to cell tip cortex
The movement of a protein along a microtubule to the cell-tip, mediated by motor proteins.
protein transport along microtubule to cell tip
The process whose specific outcome is the progression of a fungal sorus over time, from its formation to the mature structure. A fungal sorus is a spore containing structure.
fungal sorus development
A protein kinase complex comprising a conserved PAK/GC/Ste20 family kinase, leucine rich repeat protein Sog2 family, which function as part of the cell shape network.
PAK family kinase-Sog2 complex
A rapid, force generating length change of an outer hair cell in response to electrical stimulation. This occurs naturally as during hearing where it serves a source of mechanical amplification.
cochlear outer hair cell electromotile response
Binding to an estrogen.
estrogen binding
Any process during chimeric sorocarp development that increases by which a cell increases the number of spore cells sharing its genotype at the expense of cells of other genotypes.
cheating during chimeric sorocarp development
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton.
presynaptic actin cytoskeleton organization
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan.
cellular response to protozoan
The actin cytoskeleton that is part of a presynapse.
presynaptic actin cytoskeleton
Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane.
regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane
The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
extrinsic component of postsynaptic density membrane
Any process that modulates the frequency, rate or extent of synaptic vesicle docking.
regulation of synaptic vesicle docking
Any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles.
regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane
A synapse that uses serotonin as a neurotransmitter.
serotonergic synapse
Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse.
regulation of recycling endosome localization within postsynapse
The intermediate filament cytoskeleton that is part of a postsynapse.
postsynaptic intermediate filament cytoskeleton
The membrane component of the postsynaptic specialization of a symmetric synapse. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
postsynaptic specialization membrane of symmetric synapse
A network of proteins adjacent to the postsynaptic membrane of a symmetric synapse. Its major components include that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. This structure is not as thick or electron dense as the postsynaptic density found in asymmetric synapses.
postsynaptic specialization of symmetric synapse, intracellular component
The intermediate filament cytoskeleton that is part of a presynapse.
presynaptic intermediate filament cytoskeleton
The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton.
structural constituent of postsynaptic intermediate filament cytoskeleton
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprised of intermediate filament and their associated proteins in the postsynaptic cytoskeleton.
postsynaptic intermediate filament cytoskeleton organization
The portion of the spectrin-associated cytoskeleton contained within the postsynapse.
postsynaptic spectrin-associated cytoskeleton
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of spectrin-associated cytoskeleton and associated proteins in the postsynapse.
postsynaptic spectrin-associated cytoskeleton organization
A synapse formed by a cerebellar Golgi cell synapsing on to a cerebellar granule cell.
cerebellar Golgi cell to granule cell synapse
A membrane microdomain that forms a necklace around the bulb (crater) of a caveola. Intramembrane particles are concentrated in this region and cytoskeletal components, including actin, are highly enriched in the area underlying it.
caveola neck
The directed movement of synaptic vesicles along actin filaments within a cell, powered by molecular motors.
synaptic vesicle transport along actin filament
The region of the cytosol consisting of all cytosol that is part of the presynapse.
presynaptic cytosol
The region of the cytosol consisting of all cytosol that is part of the postsynapse.
postsynaptic cytosol
The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission.
presynaptic process involved in chemical synaptic transmission
Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission.
protein catabolic process, modulating synaptic transmission
Cell-cell signaling between presynapse and postsynapse, via the release and reception of carbon monoxide molecules, that modulates the synaptic transmission properties of the synapse.
trans-synaptic signaling by carbon monoxide, modulating synaptic transmission
Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse.
trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
The process by which alignment between postsynaptic density and presynaptic active zone is maintained.
maintenance of alignment of postsynaptic density and presynaptic active zone
The binding of a synaptic membrane to the extracellular matrix via adhesion molecules.
synaptic membrane adhesion to extracellular matrix
A process which maintains the organization and the arrangement of proteins in the presynaptic density.
maintenance of postsynaptic density structure
Any process that modulates synaptic transmission via modification of the structure of the synapse.
modification of synaptic structure, modulating synaptic transmission
Any process that modulates synaptic transmission by regulating protein degradation at the synapse.
regulation of protein catabolic process at synapse, modulating synaptic transmission
Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse.
regulation of protein catabolic process at presynapse, modulating synaptic transmission
Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse.
regulation of protein catabolic process at postsynapse, modulating synaptic transmission
Any process that modulates synaptic transmission by regulating translation occurring at the presynapse.
regulation of translation at presynapse, modulating synaptic transmission
Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.
regulation of translation at postsynapse, modulating synaptic transmission
The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the presynaptic cytosol.
release of sequestered calcium ion into presynaptic cytosol
The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol.
release of sequestered calcium ion into postsynaptic cytosol
Any process that increases the concentration of calcium ions in the postsynaptic cytosol.
positive regulation of postsynaptic cytosolic calcium concentration
Fusion of an endocytosed synaptic vesicle with an endosome.
endocytosed synaptic vesicle to endosome fusion
Any process that regulates the frequency of action potentials in a spike train.
regulation of action potential firing rate
Binding to the side of a microtubule.
microtubule lateral binding
Any process that regulates the potential at which an axon potential is triggered.
regulation of action potential firing threshold
The process of directing proteins towards the cell-wall.
protein localization to cell wall
The component of the matrix side of the mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
extrinsic component of matrix side of mitochondrial inner membrane
The process during which neurotransmitter receptors in the postsynaptic specialization membrane are recycled via the endosome. This cycle includes release from anchoring (trapping), diffusion in the synaptic membrane to the postsynaptic endocytic region, endocytosis, transport to the endosome, recycling in the endosome, transport back the synaptic membrane and subsequent trapping in the postsynaptic specialization membrane.
postsynaptic neurotransmitter receptor cycle
The cytoplasmic component of the postsynaptic endocytic zone.
postsynaptic endocytic zone cytoplasmic component
Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission.
voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels
The directed flow of cytosol (the liquid component of the cytoplasm) and the organelles it contains.
cytoplasmic streaming
Vesicle-mediated transport of a neurotransmitter receptor vesicle from the plasma membrane to the endosome.
neurotransmitter receptor transport, plasma membrane to endosome
The induction of synaptic vesicle release by any process that leads to a rise in intracellular calcium ion concentration at the presynapse. This is the first step in synaptic transmission.
induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration
Any prostaglandin biosynthetic process process that positively_regulates fever generation.
positive regulation of fever generation by prostaglandin biosynthetic process
Any prostaglandin secretion process that positively_regulates fever generation.
positive regulation of fever generation by prostaglandin secretion
The lipid bilayer surrounding a ficolin-1-rich granule.
ficolin-1-rich granule membrane
The lipid bilayer surrounding the cytolytic granule.
cytolytic granule membrane
Binding to the FMN-binding domain of a protein.
FMN-binding domain binding
A ribonuclease complex that has 3-prime to 5-prime distributive hydrolytic exoribonuclease activity and in some taxa (e.g. yeast) endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
nucleolar exosome (RNase complex)
The modification of a tRNA anticodon loop by replacing guanine with queuonine. Reaction is tRNA guanine + queuine = tRNA queuine + guanine.
tRNA-guanine transglycosylation
Catalysis of the reaction: L-isoleucine + 2 O2 + 2 NADPH(4-) + 2 H+ = (E)-2-methylbutanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O.
isoleucine N-monooxygenase (oxime forming) activity
Catalysis of the reaction: L-valine + 2 O2 + 2 NADPH(4-) + 2 H+ = (E)-2-methylpropanal oxime + 2 NADP(3-) + carbon dioxide + 3 H2O.
valine N-monooxygenase (oxime forming) activity
Catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone = H+ + an N-acyl-L-homoserine.
acyl-L-homoserine-lactone lactonohydrolase activity
Catalysis of the reaction: H2O + a dipeptide with proline at the C-terminal = L-proline + a standard alpha amino acid.
proline dipeptidase activity
Catalysis of the reaction: ATP(4-) + beta-D-galactoside + H2O = ADP(3-) + hydrogenphosphate + beta-D-galactoside + H+.
beta-D-galactose-importing ATPase activity
Catalysis of the reaction: (R)-lactate + an ubiquinone = pyruvate + an ubiquinol.
D-lactate dehydrogenase (quinone) activity
Catalysis of the reaction: dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose + beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-ditrans,polycis-undecaprenol = H+ + alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc-undecaprenyl diphosphate + dTDP.
4-acetamido-4,6-dideoxy-D-galactose transferase activity
Catalysis of the reaction: a tetrahydrofolate + a  = an N5-methyl-tetrahydrofolate + a .
methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity
Catalysis of the reaction: H+ + 4-nitrotoluene + NADH + O2 = 4-nitrobenzyl alcohol + NAD+ + H2O.
4-nitrotoluene monooxygenase activity
Catalysis of the reaction: 4-nitrobenzyl alcohol + O2 = 4-nitrobenzaldehyde + hydrogen peroxide.
4-nitrobenzyl alcohol oxidase activity
Catalysis of the reaction: 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate = N--4-(beta-D-ribofuranosyl)aniline 5'-phosphate + diphosphoric acid.
7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase
Catalysis of the reaction: 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonic acid + H2O + NAD = 3-dehydroquinate + ammonium + NADH + H+.
dehydroquinate synthase activity
Catalysis of the reaction: isopentenyl phosphate(2-) + ATP(4-) = isopentenyl diphosphate(3-) + ADP(3-).
isopentenyl phosphate kinase activity
Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor = 3-chlorobenzoate-cis-4,5-diol + an oxidized electron acceptor.
3-chlorobenzoate-4,5-oxygenase activity
Catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor = 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor.
3-chlorobenzoate-3,4-oxygenase activity
Catalysis of the reaction: 3,4-dichlorobenzoate + O2 + a reduced electron acceptor = 3,4-dichlorobenzoate-cis-4,5-diol + an oxidized electron acceptor.
3,4-dichlorobenzoate-4,5-oxygenase activity
Catalysis of the reaction: indole-3-acetate + glycine + ATP(4-) = H+ + indole-3-acetyl-glycine + AMP(2-) + diphosphoric acid.
indole-3-acetyl-glycine synthetase activity
Catalysis of the reaction: indole-3-acetate + L-isoleucine + ATP(4-) = H+ + indole-3-acetyl-isoleucine + AMP(2-) + diphosphoric acid.
indole-3-acetyl-isoleucine synthetase activity
Catalysis of the reaction: indole-3-acetate + L-methionine + ATP(4-) = H+ + indole-3-acetyl-methionine + AMP(2-) + diphosphoric acid.
indole-3-acetyl-methionine synthetase activity
Catalysis of the reaction: 3-maleylpyruvate(2-) + H2O = H+ + maleate(2-) + pyruvate.
maleylpyruvate hydrolase activity
Catalysis of the reaction: 2-cis,6-cis-farnesyl diphosphate = (+)-alpha-santalene + diphosphoric acid.
alpha-santalene synthase activity
Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = gamma-curcumene + diphosphoric acid.
gamma-curcumene synthase activity
Catalysis of the reaction: (E)-3,7,11,15-tetramethylhexadec-2-en-1-yl diphosphate + 3 NADP = 2-trans,6-trans,10-trans-geranylgeranyl diphosphate + 3 NADPH + 3 H+.
geranylgeranyl diphosphate reductase activity