NothingMuch/GO-Terms huggingface dataset:
Separation of a motor axon away from a bundle of axons known as a fascicle.
defasciculation of motor neuron axon
The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.
ventral cord development
The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure.
stomatogastric nervous system development
The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster.
tracheal outgrowth, open tracheal system
The process, occurring in the larva, by which the anatomical structures of the salivary gland are generated and organized.
larval salivary gland morphogenesis
The process in which the anatomical structures of the adult salivary gland are generated and organized.
adult salivary gland morphogenesis
The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments.
oenocyte development
The process in which the R1/R6 photoreceptors commit to their cell fate. R1 and R6 are paired photoreceptors which contribute the outer rhabdomeres.
R1/R6 cell fate commitment
The process in which the R2/R5 photoreceptors commit to their cell fate. R2 and R5 are paired photoreceptors which contribute the outer rhabdomeres.
R2/R5 cell fate commitment
The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres.
R3/R4 cell fate commitment
The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing.
wing disc proximal/distal pattern formation
The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg.
leg disc proximal/distal pattern formation
The negative regulation of the differentiation of polytenized larval hypodermal cells from abdominal histoblasts. The abdominal histoblasts remain a small cluster of diploid cells among the polytenized larval hypodermal cells.
maintenance of imaginal histoblast diploidy
The process in which the anatomical structures of the tergite are generated and organized. The tergite is the primary plate or sclerite forming the dorsal surface of any insect body segment.
tergite morphogenesis
The process in which the anatomical structures of the sternite are generated and organized. The sternite is the plate or sclerite on the underside of a body segment.
sternite morphogenesis
The process whose specific outcome is the progression of the anterior midgut over time, from its formation to the mature structure.
anterior midgut development
The process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure.
posterior midgut development
The process whose specific outcome is the progression of the digestive tract mesoderm over time, from its formation to the mature structure. The digestive tract mesoderm is portion of the middle layer of the three primary germ layers of the embryo which will go on to form part of the digestive tract of the organism.
digestive tract mesoderm development
The process whose specific outcome is the progression of the larval fat body over time, from its formation to the mature structure. The larval fat body consists of a bilaterally symmetrical monolayer of cells lying between the gut and the muscles of the body wall. As in other tissues of the larva, the cells of the fat body complete their divisions in the embryo and increase in size and ploidy during larval life.
larval fat body development
The process whose specific outcome is the progression of the adult fat body over time, from its formation to the mature structure. Larval fat body cells that remain at eclosion degenerate in the first 2 to 4 days of adult life, leaving behind the smaller cells of the adult fat body.
adult fat body development
The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism.
gonadal mesoderm development
The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper.
larval heart development
The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism.
mesoderm migration involved in gastrulation
The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
cardioblast cell fate determination
The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure.
larval visceral muscle development
The process whose specific outcome is the progression of the adult visceral muscle over time, from its formation to the mature structure.
adult visceral muscle development
The biological process in which a synapse between a motor neuron and a muscle is initially formed.
establishment of synaptic specificity at neuromuscular junction
The activation of recombination at a mating type locus, such that it is used in preference to the other donor locus for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae.
activation of recombination (HML)
The inactivation of recombination at sequences around a mating type donor locus, with the consequence that the other donor is the only one available for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae.
inactivation of recombination (HML)
The developmental process in which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it.
sex determination, establishment of X:A ratio
The developmental process in which an organism interprets its X to autosomal chromosomal complement.
sex determination, primary response to X:A ratio
The events determining the somatic sexual phenotype after the initial transmission of that phenotype to soma-specific information pathways.
somatic processes downstream of sex determination signal
The events determining the germ-line sexual phenotype after the initial transmission of that phenotype to germ-line-specific information pathways.
germ-line processes downstream of sex determination signal
The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis.
imaginal disc eversion
The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.
short-term memory
The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis.
anesthesia-resistant memory
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
long-term memory
The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes.
mating
Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the meristem.
homeostasis of number of meristem cells
The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
chemokine activity
Binding to a catenin beta subunit.
beta-catenin binding
The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis.
eclosion hormone activity
Combining with a diuretic hormone and transmitting the signal to initiate a change in cell activity.
diuretic hormone receptor activity
Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration.
calcium sensitive guanylate cyclase activator activity
Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.
chitin binding
The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn.
eclosion rhythm
Binds to and stops, prevents or reduces the activity of ornithine decarboxylase.
ornithine decarboxylase inhibitor activity
Complex that possesses guanylate cyclase activity and is not bound to a membrane.
guanylate cyclase complex, soluble
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
growth factor activity
Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins.
spectrin
Catalysis of the hydrolysis of the epoxide in a juvenile hormone to the corresponding diol.
juvenile hormone epoxide hydrolase activity
Binding to an unprocessed 5S ribosomal RNA transcript.
5S rRNA primary transcript binding
Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster.
oocyte microtubule cytoskeleton polarization
Binding to oxysterol, an oxidized form of cholesterol.
oxysterol binding
Binding to phenylalkylamine or one of its derivatives.
phenylalkylamine binding
The action of a molecule that contributes to the structural integrity of bone.
structural constituent of bone
Binding to a protein phosphatase 1.
protein phosphatase 1 binding
Binds to and increases the activity of a phosphotyrosine phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein.
protein tyrosine phosphatase activator activity
Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate.
glycogen phosphorylase activity
Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs.
tRNA guanylyltransferase activity
Receiving vitellogenin, and delivering vitellogenin into the cell via endocytosis.
vitellogenin receptor activity
Binding to a ferrous iron ion, Fe(II).
ferrous iron binding
Binding to a ferric iron ion, Fe(III).
ferric iron binding
Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine.
tyramine receptor activity
Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain.
dipeptidyl-peptidase activity
Catalysis of the release of an N-terminal tripeptide from a polypeptide.
tripeptidyl-peptidase activity
Catalysis of the release of C-terminal dipeptides from a polypeptide chain.
peptidyl-dipeptidase activity
The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system.
ecdysis-triggering hormone activity
Movement of the anterior ectoderm to the interior of the embryo.
head involution
Combining with allatostatin to initiate a change in cell activity.
allatostatin receptor activity
Binding to a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein.
poly-glutamine tract binding
The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way.
JAK pathway signal transduction adaptor activity
The action of a molecule that contributes to the structural integrity of a muscle fiber.
structural constituent of muscle
Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP).
7S RNA binding
The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster.
structural constituent of vitelline membrane
Binding to a methylated cytosine/guanine dinucleotide.
methyl-CpG binding
Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
protein tyrosine/threonine phosphatase activity
The pathways that regulate the duration of the adult phase of the life-cycle of an animal.
determination of adult lifespan
A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa).
katanin complex
Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate.
4-hydroxybutyrate CoA-transferase activity
Catalysis of the transfer of a CDP-alcohol group from one compound to another.
CDP-alcohol phosphotransferase activity
Catalysis of the reaction: N-terminal L-asparaginyl- + H+ + H2O = N-terminal L-aspartyl- + NH4+. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein.
protein-N-terminal asparagine amidohydrolase activity
Catalysis of the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide.
RNA lariat debranching enzyme activity
Binds to and stops, prevents or reduces the activity of a calcium-dependent protein kinase.
calcium-dependent protein kinase inhibitor activity
Binding to a phosphatidylethanolamine, a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
phosphatidylethanolamine binding
Binding to a selenium (Se) ion.
selenium binding
Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+.
3-hydroxyisobutyrate dehydrogenase activity
Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide.
gamma-glutamyl carboxylase activity
Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide.
translation activator activity
Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin.
melatonin receptor activity
Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity.
benzodiazepine receptor activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate.
sodium-dependent multivitamin transmembrane transporter activity
Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate.
JUN kinase phosphatase activity
The process in which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the compound eye morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium. An example of this process is found in Drosophila melanogaster.
mystery cell differentiation
The action characteristic of a diuretic hormone, a peptide hormone that, upon receptor binding, regulates water balance and fluid secretion.
diuretic hormone activity
Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine.
rRNA (uridine-2'-O-)-methyltransferase activity
Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system.
penicillin binding
Catalysis of the reaction: 2-methoxy-6-(all-trans-octaprenyl)phenol + H+ + NADPH + O2 = 2-methoxy-6-all-trans-octaprenyl-1,4-benzoquinol + H2O + NADP+.
2-octaprenyl-6-methoxyphenol hydroxylase activity
Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H+.
3,4-dihydroxy-2-butanone-4-phosphate synthase activity
Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O.
3-(3-hydroxyphenyl)propionate hydroxylase activity
Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+.
GDP-mannose mannosyl hydrolase activity
Catalysis of the reaction: N-ethylmaleimide + NADPH + 2 H+ = N-ethylsuccinimide + NADP+.
N-ethylmaleimide reductase activity
Catalysis of the reaction: Lipid A-core + colanic acid = MLPS.
O antigen ligase activity
Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP.
UDP-2,3-diacylglucosamine hydrolase activity
Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine.
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol.
alkyl hydroperoxide reductase activity
Catalysis of the reaction: D-carnitine = L-carnitine.
carnitine racemase activity
Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP.
cobalamin 5'-phosphate synthase activity
Catalysis of the reaction: 2 Cu2+ + NADH = 2 Cu+ + H+ + NAD+.
cupric reductase (NADH) activity
Catalysis of the reaction: L-glutamate = D-glutamate.
glutamate racemase activity
Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+.
mannitol-1-phosphate 5-dehydrogenase activity
Catalysis of the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine residue in an unmodified prolipoprotein.
phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity
Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate.
quinolinate synthetase A activity
Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group.
ribonuclease E activity
Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group.
ribonuclease G activity
Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster.
dosage compensation by hyperactivation of X chromosome
A pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it.
Entner-Doudoroff pathway through 6-phosphogluconate
A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage.
phage shock
A type of horizontal gene transfer in which genetic material is introduced into a cell mediated by a virus.
transduction
An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA.
exodeoxyribonuclease VII complex
A protein complex that possesses cytochrome o ubiquinol oxidase activity; consists of four polypeptide subunits and associated prosthetic groups.
cytochrome o ubiquinol oxidase complex
A protein complex that possesses phosphoribosylaminoimidazole carboxylase activity.
phosphoribosylaminoimidazole carboxylase complex
An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides.
alkyl hydroperoxide reductase complex
A protein complex that possesses D-amino-acid dehydrogenase activity.
D-amino-acid dehydrogenase complex
An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2).
formate dehydrogenase complex
An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe).
phenylalanine-tRNA ligase complex
An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu).
glutamate-tRNA ligase complex
Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A.
cysteine synthase complex
Enzyme complex consisting of four proteins: the two subunits of the hydroxylase component (hcaE and hcaF), a ferredoxin (hcaC) and a ferredoxin reductase (hcaD). Converts 3-phenylpropionic acid (PP) into cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol).
3-phenylpropionate dioxygenase complex
An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA.
exodeoxyribonuclease V complex