NothingMuch/GO-Terms huggingface dataset:
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-fructose(out) + Na+(out) = D-fructose(in) + Na+(in).
fructose:sodium symporter activity
Determination of the asymmetric location of the lungs with respect to the left and right halves of the organism.
determination of lung left/right asymmetry
Any process that stops, prevents or reduces the frequency, rate or extent of AIM2 inflammasome complex assembly.
negative regulation of AIM2 inflammasome complex assembly
Any process that activates or increases the frequency, rate or extent of AIM2 inflammasome complex assembly.
positive regulation of AIM2 inflammasome complex assembly
Any process carried out at the cellular level that reduces or removes the toxicity of a sulfide. These may include chemical modification or transport of sulfide away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
cellular detoxification of sulfide
Any process carried out at the cellular level that reduces or removes the toxicity of acetone. These may include chemical modification, for example to methylglyoxal.
cellular detoxification of acetone
A homeostatic process involved in the maintenance of a steady state level of nucleotides within a cell.
intracellular nucleotide homeostasis
A homeostatic process involved in the maintenance of a steady state level of nucleosides within a cell.
intracellular nucleoside homeostasis
Catalysis of the reaction: an omega-methyl-medium-chain fatty acid + O2 + reduced  = an omega-hydroxy-medium-chain fatty acid + H+ + H2O + oxidized . A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons.
medium-chain fatty acid omega-hydroxylase activity
A G protein-coupled receptor signaling pathway initiated by a chemorepellent binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. cytoskeleton reorganization.
G protein-coupled chemorepellent receptor signaling pathway
Catalysis of the reaction: 7-deoxyloganate + O2 + reduced  = H+ + H2O + loganate + oxidized .
7-deoxyloganate 7-hydroxylase activity
The process involved in converting precursor piRNAs into non-overlapping, contiguous primary piRNAs (approximately 24-30-nt piRNAs with a preference for a 5' uridine (U) via the endonucleolytic activity of cytosolic PIWI. This may include pre-piRNA maturation of 3' ends by trimming and 2'-O-methylation.
primary piRNA processing
Catalysis of the reaction: histone H4 L-lysine (position 16) + propionyl-CoA = CoA + H+ + histone H3 N6-propionyl-L-lysyl (position 16).
histone H4K16 propionyltransferase activity
The directed import of purine nucleotide from the cytosol, across the lysosomal membrane, into the lysosome.
purine nucleotide import into lysosome
A cellular process that results in the silencing of ribosomes in quiescent cells. Quiescence takes place when cells encounter unfavorable conditions and cease to grow in bacteria and yeast. It also takes place in some specialized cells in higher eukaryotes, such as eggs. Ribosomes in a hibernation state are kept silent via association with proteins with inhibitory and protective functions.
ribosome hibernation
Hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free thymine and leaving an apyrimidinic (AP) site.
G/T mismatch-specific thymine-DNA glycosylase activity
A symbiont process in which a molecule secreted by the symbiont reactivates the host cell cycle, resulting in DNA synthesis and host cell division, and contributing to vegetative tumor formation.
effector-mediated induction of cell cycle reactivation in host
The attachment of a symbiont to its host by binding to a carbohydrate on the host cell surface. The host is defined as the larger of the organisms involved in a symbiotic interaction.
adhesion of symbiont to host cell surface via host membrane carbohydrate
The attachment of a symbiont to its host by binding to a glycoprotein on the host cell surface. The host is defined as the larger of the organisms involved in a symbiotic interaction.
adhesion of symbiont to host cell surface via host glycoprotein
The attachment of a symbiont to its host by binding to cholesterol on the host cell surface. The host is defined as the larger of the organisms involved in a symbiotic interaction.
adhesion of symbiont to host cell surface via host membrane cholesterol
The process in which an organism effects a change that impairs the structure or function of the host actin cytoskeleton by depolymerizing the host filamentous actin. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated perturbation of host actin cytoskeleton via filamentous actin depolymerization
Binds to and increases the activity of a phosphatidylinositol 3-kinase (PI3K).
phosphatidylinositol 3-kinase activator activity
Binds to and decreases the activity of a phosphatidylinositol 3-kinase (PI3K).
phosphatidylinositol 3-kinase inhibitor activity
Catalysis of the reaction: a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP+ = a very-long-chain 3-oxoacyl-CoA + H+ + NADPH. This reaction is the second (reduction) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit.
very-long-chain 3-oxoacyl-CoA reductase activity
The establishment of epigenetic modifications (imprints) in a plant central cell, leading to an asymmetry between the two maternal alleles and the paternal allele, and differential expression of the corresponding alleles in the developing endosperm. This can happen through heterochromatin formation or differential chromatin loop formation.
epigenetic programming in the central cell
A process in which a symbiont subverts an interferon-mediated signal transduction pathway in the host organism by initiating, promoting, or enhancing its activation.
symbiont-mediated activation of host interferon signaling pathway
A process in which a symbiont interferes with, inhibits or disrupts the host reactive oxygen species (ROS)-mediated innate immune response by directly degrading host ROS. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated detoxification of host-generated reactive oxygen species
Any process that increases the rate, frequency or extent of nodal signaling pathway.
positive regulation of nodal signaling pathway
Catalysis of the reaction: 5-amino-6-(D-ribitylamino)uracil + L-tyrosine + S-adenosyl-L-methionine = 2-iminoacetate + 5'-deoxyadenosine + 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + H+ + L-methionine.
5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase activity
Binding to a DNA loop anchor, a region of chromosome that defines the ends of a DNA loop where two parts of same DNA strand are held in close physical proximity. For example, in animals, the anchors of DNA loops are convergently oriented CTCF binding sites during interphase.
DNA loop anchor binding
A DNA-binding transcription repressor activity regulated by binding to a ligand and that inhibits the transcription of specific genes and gene sets.
ligand-activated transcription repressor activity
A DNA-binding transcription activator activity regulated by binding to a ligand and that activates the transcription of specific genes and gene sets.
ligand-activated transcription activator activity
A process in which a symbiont initiates, promotes, or enhances a G protein-coupled receptor signal transduction pathway in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated activation of host G protein-coupled receptor signal transduction
Binds to and increases the activity of a methyltransferase.
tRNA methyltransferase activator activity
Any process that activates or increases the frequency, rate or extent of of cGAS/STING signaling pathway.
positive regulation of cGAS/STING signaling pathway
The process of bringing together chromosomes fragments resulting from DNA damage. Broken chromosome tethering during mitosis ensures clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss and enhancing genome integrity.
broken chromosome clustering
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway, planar cell polarity pathway.
negative regulation of Wnt signaling pathway, planar cell polarity pathway
Catalysis of the reaction: Fe(II)-heme b- + nitric oxide + O2 = Fe(III)-heme b- + nitrate.
nitric oxide dioxygenase activity, heme protein as donor
The disruption of the skin of another organism, leading to damage or temporary subversion of the skin.
dermonecrosis in another organism
Reactions triggered in response to the presence of a host that act to protect or prevent damage to the symbiont.
defense response to host
Catalysis of the reaction: 2--L-histidyl- + 4 S-adenosyl-L-methionine = diphthine methyl ester- + 3 H+ + 4 S-adenosyl-L-homocysteine.
diphthine methyl ester synthase activity
A process in which a symbiont interferes with, inhibits or disrupts a chemokine signaling pathway, a G protein-coupled receptor signal transduction pathway activated by a chemokine. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated suppression of host chemokine signal transduction pathway
The disruption of the host mucosa by a symbiont, leading to damage or temporary subversion of that tissue. The mucosa is a membrane that lines various cavities in the body of an organism and covers the surface of internal organs.
symbiont-mediated disruption of host mucosa
Catalysis of the reaction: a 2,3-saturated acyl- + NADP+ = a (2E)-enoyl- + H+ + NADPH.
enoyl- reductase (NADPH) activity
Any process that increases the rate, frequency or extent of nitric oxide-cGMP mediated signal transduction.
positive regulation of nitric oxide-cGMP mediated signal transduction
Any process that decreases the rate, frequency or extent of nitric oxide-cGMP mediated signal transduction.
negative regulation of nitric oxide-cGMP mediated signal transduction
A process in which a symbiont inhibits or disrupts the translation elongation of host mRNA into protein, for example by directly inhibiting elongation factors. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated suppression of host translation elongation
A process in which a symbiont inhibits or disrupts the normal execution of  host exocytosis. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated suppression of host exocytosis
A process in which a symbiont inhibits or disrupts the normal maturation of host phagosomes. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated suppression of host phagosome maturation
A process in which a symbiont inhibits or disrupts the normal acidification of host phagosomes. Mechanisms by which a symbiont prevents host phagosome acidification include the inhibitition of host V-ATPase, the proton pump that acidifies the phagosome, or disruption of the phagosome membrane by pore-forming toxin. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated suppression of host phagosome acidification
The process in which an organism effects a change that impairs the structure or function of host phagosomes.
symbiont-mediated disruption of host phagosome
The chemical reactions and pathways resulting in the breakdown of misfolded proteins in the mitochondrion, which are targeted for degradation.
mitochondrial protein quality control
Any process that activates or increases the frequency, rate or extent of positive regulation of 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway.
positive regulation of 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway
A protein-protein adaptor that acts as a platform for receptor clustering, often serving to amplify the sensitivity of a signaling response.
receptor clustering activity
A process by which a symbiont avoids the effects of recognition by a host  antimicrobial peptide by altering molecules on the symbiont surface. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated evasion of recognition by host antimicrobial peptide
A chromatin-protein adaptor activity that bridges dsDNA and chromatin proteins to bring regions of a chromosome in proximity. The DNA:DNA:RNA triple-helical structure is formed non-Watson-Crick base-pairing.
dsDNA-RNA triple helix-forming chromatin adaptor activity
A process in which a symbiont subverts an anti-inflammatory cytokine signaling pathway in the host organism by initiating, promoting, or enhancing its activation.
symbiont-mediated activation of host anti-inflammatory cytokine signaling
Any process that stops, prevents, or reduces the frequency, rate or extent of HRI-mediated signaling.
negative regulation of HRI-mediated signaling
A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at various positions of the ubiquitin monomers, forming branched linkages, such as K11/K48- or K11/K63-linked chains.
protein branched polyubiquitination
The chemical reactions and pathways resulting in the formation of GDP-mannose from glucose.
GDP-mannose biosynthetic process from glucose
Catalysis of the reaction: UTP + thiamine = UMP + thiamine diphosphate.
UTP thiamine diphosphokinase activity
A process in which a symbiont alters or subverts vacuole organization in its host organism to form a protected environment in which it can replicate. The host is defined as the larger of the organisms involved in a symbiotic interaction.
symbiont-mediated generation of symbiont replication vacuole
Catalysis of the reaction: N-acetyltaurine + H2O = acetate + taurine.
N-acetyltaurine hydrolase activity
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + NAD+ + H2O = histone H3 L-lysine (position 14) + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group attached to a lysine residue in H3K4 to NAD, producing nicotinamide.
histone H3K4 deacetylase activity, NAD-dependent
A dendrite emerging from the cell body (the soma) of a neuron.
primary dendrite
The part of the dendritic spine neck where the spine arises from the dendritic shaft.
dendritic spine origin
A protein complex required for the activation of urease. Activator subunits dissociate before urease has catalytic function.
urease activator complex
Clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds.
clathrin-dependent synaptic vesicle endocytosis
Any dendrite in a dendritic tree that emerges near the apical pole of a neuron, and which is farthest away from the neuronal cell body (the soma).
apical distal dendrite
The dendrite of the dendritic tree, which emerges near the apical pole of a neuron, and which is the closest to the cell body of the neuron (the soma).
apical proximal dendrite
Any dendrite in a dendritic tree that emerges near the basal pole of a neuron (e.g. in bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon), and which is farthest away from the neuronal cell body (the soma).
basal distal dendrite
Any dendrite in a dendritic tree that emerges near the basal pole of a neuron (e.g. in bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon), and which is the closest to the cell body of the neuron (the soma).
basal proximal dendrite
The process in which the anatomical structures of a dendritic tree are generated on the basal neuron side and organized into dendritic branches.
basal dendrite arborization
The process in which the anatomical structures of a dendritic tree are generated on the apical neuron side and organized into dendritic branches.
apical dendrite arborization
Any process that activates or increases the frequency, rate or extent of protein localization to lysosome.
positive regulation of protein localization to lysosome
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome.
negative regulation of protein localization to lysosome
Any process that modulates the frequency, rate or extent of trans-synaptic signaling by BDNF, modulating synaptic transmission.
regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission
Any process that modulates the frequency, rate or extent of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission.
regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
Any process that modulates the frequency, rate or extent of calcium-dependent activation of synaptic vesicle fusion.
regulation of calcium-dependent activation of synaptic vesicle fusion
Any process that modulates the frequency, rate or extent of postsynaptic dense core vesicle exocytosis.
regulation of postsynaptic dense core vesicle exocytosis
Any process that modulates the frequency, rate or extent of synaptic signaling by nitric oxide.
regulation of synaptic signaling by nitric oxide
The portion of the septin cytoskeleton contained within the postsynapse.
postsynaptic septin cytoskeleton
Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse.
regulation of postsynapse assembly
Any process that modulates the frequency, rate or extent of postsynaptic neurotransmitter receptor diffusion trapping.
regulation of postsynaptic neurotransmitter receptor diffusion trapping
Any process that stops, prevents or reduces the frequency, rate or extent of deacetylase activity.
negative regulation of deacetylase activity
Any process that modulates the frequency, rate or extent of tubulin deacetylase activity.
regulation of tubulin deacetylase activity
Any process that activates or increases the frequency, rate or extent of arginase activity.
positive regulation of arginase activity
Any process that activates or increases the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity.
positive regulation of protein-glutamine gamma-glutamyltransferase activity
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and a single dendrite.
multiple spine synapse organization, single dendrite
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse between a multiple synapse bouton and two or more dendritic spines protruding either from a single dendrite or from multiple dendrites.
multiple spine synapse organization, multiple dendrites
The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by transcytosis across the blood-brain barrier.
amyloid-beta clearance by transcytosis
Any process that modulates the frequency, rate or extent of microtubule anchoring at centrosome.
regulation of microtubule anchoring at centrosome
Any process that modulates the frequency, rate or extent of transepithelial transport.
regulation of transepithelial transport
Any process that activates or increases the frequency, rate or extent of phosphatidylethanolamine metabolic process.
positive regulation of phosphatidylethanolamine metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylethanolamine metabolic process.
negative regulation of phosphatidylethanolamine metabolic process
Cell-cell signaling that starts with the activation of extrasynaptic GABA receptors in neurons through binding of ambient gamma-aminobutyric acid present in the extracellular fluid.
extrasynaptic signaling via GABA
Binding to a protein upon mono-ADP-ribosylation of the target protein.
mono-ADP-D-ribose modification-dependent protein binding
Binding to a protein upon poly-ADP-ribosylation of the target protein.
poly-ADP-D-ribose modification-dependent protein binding
A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the correct folding of multipass membrane proteins in the ER membrane. In human, the substrate-binding Asterix (PAT10, WDR83OS) forms an obligate heterodimer with CCDC47.
PAT complex
The process in which glutathione is transported from the cytosol into the mitochondrial matrix.
glutathione import into mitochondrion
Catalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl- = 2-hydroxy-2-methylpropanoate + L-lysyl-.
protein de-2-hydroxyisobutyrylase activity
Catalysis of the reaction: H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl- + NAD+ = 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl- + nicotinamide.
NAD-dependent protein de-2-hydroxyisobutyrylase activity
An extracellular vesicle that is approximately four microns in diameter, released by budding out of cells into the extracellular space, and hypothesized to be a mechanism for disposal of unwanted cellular material including protein aggregates and damaged organelles.
exopher
Catalysis of the reaction: an unstable tRNA + 2 ATP + 4 CTP = a tRNA with a 3' CCACCA end + 6 diphosphate.
CCACCA tRNA nucleotidyltransferase activity
Any process that increases the rate, frequency, or extent of platelet rolling.
positive regulation of platelet rolling
Any process that decreases the rate, frequency, or extent of platelet rolling.
negative regulation of platelet rolling
Any process that activates or increases the frequency, rate or extent of ferroptosis.
positive regulation of ferroptosis
The multiplication or reproduction of Leydig cells, resulting in the expansion of a cell population. Leydig cells are interstitial cells located adjacent to the seminiferous tubules in the testis which produce testosterone.
Leydig cell proliferation
The multicellular organismal reproductive process that results in the movement of an egg from within an organism into the external environment.
egg deposition
The process in which a kidney cortex tubule cell (specialized epithelial cell of the kidney) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.
kidney cortex tubule cell dedifferentiation
Formation of pollen intine, the inner layer of the pollen wall. The reticulate pollen wall pattern consists of two layers, exine and intine.
pollen intine formation
Any process that activates or increases the frequency, rate or extent of Toll receptor ligand protein activation cascade.
positive regulation of Toll receptor ligand protein activation cascade
Any process that stops, prevents or reduces the frequency, rate or extent of Toll receptor ligand protein activation cascade.
negative regulation of Toll receptor ligand protein activation cascade
Any process that activates or increases the frequency, rate or extent of postsynaptic density assembly.
positive regulation of postsynaptic density assembly
Any process that decreases the rate, frequency, or extent of postsynaptic density assembly.
negative regulation of postsynaptic density assembly
Enables the transmembrane transfer of a chloride ion by a channel that opens when the biogenic amine serotonin has been bound by the channel complex or one of its constituent parts. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
serotonin-gated chloride channel activity
A migrasome-mediated selective removal of damaged mitochondria process that maintains mitochondrion homeostasis in migrating cells.
mitocytosis