NothingMuch/GO-Terms huggingface dataset:
Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum.
proepicardium development
The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart.
proepicardium cell migration involved in pericardium morphogenesis
The orderly movement of a cell that have undergone an epithelial to mesenchymal transition from the epicardium into the myocardium.
epicardium-derived cell migration to the myocardium
A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium.
epicardial cell to mesenchymal cell transition
The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell.
epicardium-derived cardiac endothelial cell differentiation
The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein.
pulmonary myocardium development
The directed, self-propelled movement of cilia of inner ear epithelial cells, resulting the aggregation of otolith seed particles.
cilium movement involved in otolith formation
The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron that is part of the brainstem.
noradrenergic neuron fate commitment involved in brainstem development
Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self-propelled movement of a mesendodermal cell.
lamellipodium assembly involved in mesendodermal cell migration
The binding of a cell to the extracellular matrix that contributes to the directed movement of a mesendodermal cell.
cell-matrix adhesion involved in mesendodermal cell migration
The attachment of mesendodermal cells to each other that contributes to the establishment of cell polarity that is part of the directed movement of the cells of the mesendoderm.
cell-cell adhesion involved in mesendodermal cell migration
Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating mesendodermal cell.
establishment or maintenance of cytoskeleton polarity involved in mesendodermal cell migration
The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite in a neuron of the amphid sensory organ.
cell adhesion involved in amphid sensory organ dendrite retrograde extension
The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite of a neuron in the amphid sensory organ.
neuron migration involved in amphid sensory organ dendrite retrograde extension
The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the amphid sensory organ.
glial cell differentiation involved in amphid sensory organ development
Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat.
regulation of COPII vesicle coating
The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.
optic vesicle formation
The developmental growth that results in the lengthening of the optic vesicle in the posterior direction.
optic vesicle elongation
The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle.
optic cup formation involved in camera-type eye development
A 90 degree-rotation of the optic cup resulting in its alignment with the anterior-posterior body axis.
anterior rotation of the optic cup
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye.
cell motility involved in camera-type eye morphogenesis
The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye.
establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate.
establishment of mitotic spindle orientation involved in growth plate cartilage chondrocyte division
The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone.
chondrocyte intercalation involved in growth plate cartilage morphogenesis
The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time.
cell growth involved in growth plate cartilage chondrocyte morphogenesis
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix and contributes to the shaping of the growth plate cartilage of an endochondral bone.
regulation of cell adhesion involved in growth plate cartilage morphogenesis
Any process that modulates the frequency, rate or extent of cell communication that contributes to the shaping of the growth plate cartilage.
regulation of cell communication involved in growth plate cartilage morphogenesis
Binding to DNA in a bent conformation.
bent DNA binding
Binding to double-stranded telomere-associated DNA.
double-stranded telomeric DNA binding
Binding to DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags.
left-handed Z-DNA binding
Binding to a P-element, a class of Drosophila transposon responsible for hybrid dysgenesis.
P-element binding
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
translation initiation factor activity
Functions in chain elongation during polypeptide synthesis at the ribosome.
translation elongation factor activity
Binding to an actin filament along its length.
actin lateral binding
Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R.
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate.
3-dehydroquinate synthase activity
Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer.
DNA primase activity
Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA.
DNA (6-4) photolyase activity
Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H+.
GMP synthase activity
Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor.
GPI-anchor transamidase activity
Catalysis of the reaction: H2O + 2 NAD+ + UDP-alpha-D-glucose = 3 H+ + 2 NADH + UDP-alpha-D-glucuronate.
UDP-glucose 6-dehydrogenase activity
Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.
3-chloroallyl aldehyde dehydrogenase activity
Catalysis of the reaction: a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 phosphate. This reaction consists of two distinct successive phosphate-releasing steps, with NDPs as intermediates. Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs).
apyrase activity
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP.
3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP.
3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
Catalysis of the cleavage of branch points in branched glycogen polymers.
glycogen debranching enzyme activity
Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3.
dihydropterin deaminase activity
Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide.
dihydropterin oxidase activity
Catalysis of the reaction: H2O + L-histidinol + 2 NAD+ = 3 H+ + L-histidine + 2 NADH.
histidinol dehydrogenase activity
Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+.
homoserine dehydrogenase activity
Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose.
poly(ADP-ribose) glycohydrolase activity
DNA dependent catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein.
DNA-dependent protein kinase activity
Catalysis of the reaction: ATP +  = ADP +  phosphate.
eukaryotic translation initiation factor 2alpha kinase activity
Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP.
ribosomal protein S6 kinase activity
Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.
non-membrane spanning protein tyrosine phosphatase activity
Catalysis of the hydroxylation of tyramine to form octopamine.
tyramine-beta hydroxylase activity
Binds to and stops, prevents or reduces the activity of dUTP pyrophosphatase.
dUTP pyrophosphatase inhibitor activity
Binds to and stops, prevents or reduces the activity of a cAMP-dependent protein kinase.
cAMP-dependent protein kinase inhibitor activity
Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate.
protein serine/threonine phosphatase inhibitor activity
Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane.
asialoglycoprotein receptor activity
Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
complement component C3b receptor activity
The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell and to initiate intracellular signaling. Cell adhesion receptors include integrins and cadherins.
cell adhesion receptor activity
Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
erythropoietin receptor activity
Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
growth hormone receptor activity
Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
oncostatin-M receptor activity
Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
prolactin receptor activity
An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms.
angiotensin type II receptor activity
Combining with bombesin to initiate a change in cell activity.
bombesin receptor activity
Combining with bradykinin to initiate a change in cell activity.
bradykinin receptor activity
Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
calcitonin receptor activity
Combining with galanin to initiate a change in cell activity.
galanin receptor activity
Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
glucagon receptor activity
Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
histamine receptor activity
Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist.
octopamine receptor activity
Combining with oxytocin to initiate a change in cell activity.
oxytocin receptor activity
Combining with parathyroid hormone to initiate a change in cell activity.
parathyroid hormone receptor activity
Combining with thyrotropin-releasing hormone to initiate a change in cell activity.
thyrotropin-releasing hormone receptor activity
Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates.
transferrin receptor activity
Combining with vasoactive intestinal polypeptide to initiate a change in cell activity.
vasoactive intestinal polypeptide receptor activity
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
transmembrane receptor protein tyrosine phosphatase activity
Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity.
laminin receptor activity
Combining with the extracellular matrix ligand tiggrin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
tiggrin receptor activity
The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way.
guanyl-nucleotide exchange factor adaptor activity
Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding.
Rab GDP-dissociation inhibitor activity
Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding.
Rho GDP-dissociation inhibitor activity
Binding to CD40, a receptor found on the surface of all B-lymphocytes.
CD40 receptor binding
Binding to a CD27, a receptor found on the surface of T cells and some B cells and NK cells.
CD27 receptor binding
The action of a molecule that contributes to the structural integrity of the lens of an eye.
structural constituent of eye lens
Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential.
A-type (transient outward) potassium channel activity
Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow.
delayed rectifier potassium channel activity
Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration.
open rectifier potassium channel activity
Enables the transfer of a GDP-fucose from one side of a membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate.
GDP-fucose transmembrane transporter activity
Enables the transfer of a GDP-mannose from one side of a membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate.
GDP-mannose transmembrane transporter activity
Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate.
UDP-galactose transmembrane transporter activity
Enables the transfer of a UDP-glucose from one side of a membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate.
UDP-glucose transmembrane transporter activity
Enables the transfer of a UDP-glucuronic acid from one side of a membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate.
UDP-glucuronic acid transmembrane transporter activity
Enables the transfer of a UDP-N-acetylglucosamine from one side of a membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.
UDP-N-acetylglucosamine transmembrane transporter activity
Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.
UDP-N-acetylgalactosamine transmembrane transporter activity
Enables the transfer of UDP-xylose from one side of a membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate.
UDP-xylose transmembrane transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out).
succinate:fumarate antiporter activity
Binding to an androgen, a male sex hormone.
androgen binding
Binding to a juvenile hormone, a sesquiterpenoid derivative that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis.
juvenile hormone binding
Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
calmodulin binding
Binding to a protein involved in modulating the reorganization of the cytoskeleton.
cytoskeletal regulatory protein binding
Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin.
profilin binding
Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle.
tropomyosin binding
Binding to GTP, guanosine triphosphate.
GTP binding
Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
calcium-dependent phospholipid binding
Binding to a phosphatidylinositol, a glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
1-phosphatidylinositol binding
Binding to a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process.
pheromone binding
A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes where it bridges between fibrils.
collagen type XV trimer
A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils.
collagen type I trimer
A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils.
collagen type II trimer
A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils.
collagen type III trimer
A collagen heterotrimer containing type IV alpha chains; 2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes.
collagen type IV trimer
A collagen heterotrimer containing type V alpha chains; 2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils.
collagen type V trimer
A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils.
collagen type VI trimer
A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue. It binds laminin.
collagen type VII trimer
A collagen heterotrimer containing type VIII alpha chains; alpha2(VIII) and alpha1(VIII)2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets.
collagen type VIII trimer
A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils.
collagen type XI trimer
A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils.
collagen type IX trimer
A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures.
collagen type XII trimer
A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures.
collagen type XIV trimer
A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils.
collagen type XVI trimer
A collagen homotrimer of alpha1(X) chains; type X collagen triple helices form hexagonal networks (sheets).
collagen type X trimer