NothingMuch/GO-Terms huggingface dataset:
The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph.
lymph gland crystal cell differentiation
The symmetric outward movement of the syncytial nuclei from their positions in the ellipsoid toward the periphery of the embryo, during mitotic cycles 8 and 9. This movement results in the placement of nuclei in a uniform monolayer at the cortex of the developing embryo.
nuclear cortical migration
Formation and/or maintenance of a lineage boundary between anterior and posterior compartments of the leg disc that cells cannot cross, thus separating the populations of cells in each compartment.
leg disc anterior/posterior lineage restriction
The process in which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk.
spermathecum morphogenesis
Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells.
cell competition in a multicellular organism
The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium).
genital disc anterior/posterior pattern formation
Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two.
determination of genital disc primordium
Binding to the catalytic subunit of glutamate-cysteine ligase.
glutamate-cysteine ligase catalytic subunit binding
The directed movement of a germ cell from their site of production to the gonad, through the attraction of cells towards their target.
germ cell attraction
The directed movement of a germ cell from their site of production to the gonad, through the repulsion of cells away from a tissue.
germ cell repulsion
Combining with the neuropeptide proctolin, to initiate a change in cell activity.
proctolin receptor activity
Combining with the neuropeptide corazonin to initiate a change in cell activity.
corazonin receptor activity
Binding to dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine.
dopamine binding
Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
ionotropic glutamate receptor binding
The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals.
internal genitalia morphogenesis
The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals.
external genitalia morphogenesis
The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed.
genital disc sexually dimorphic development
Progression of the ring gland over time, from its formation to a mature structure. The ring gland is a neuroendocrine organ found in higher Dipterans, which is composed of the prothoracic gland, the corpus allatum, and the corpora cardiacum. The ring gland is the site of production and release of ecdysteroids and juvenile hormones.
ring gland development
Binding to a phthalate, any ester or salt of phthalic acid.
phthalate binding
Binding to ethanol, CH(3)-CH(2)-OH.
ethanol binding
Division of the brain into a series of semi-repetitive parts or segments.
brain segmentation
The specification of the characteristic structures of the intercalary segment of the anterior head, following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.
specification of segmental identity, intercalary segment
The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster.
chitin-based larval cuticle pattern formation
Allocation of embryonic cells to the wing disc founder populations, groups of cells that are committed to contribute to the formation of a wing imaginal disc.
determination of wing disc primordium
Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producing tubes with a cirumference of two cells.
regulation of Malpighian tubule diameter
Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods.
ecdysteroid 25-hydroxylase activity
The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment.
notum cell fate specification
The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a wing cell, if left in its normal environment.
wing cell fate specification
Formation of hardened covering (a scab) at a wound site. The scab has multiple functions including limiting blood loss, providing structural stability to the wound and guarding against infection.
scab formation
The orderly movement of a mesenchymal cell from one site to another that will contribute to the formation of a limb bud.
mesenchymal cell migration involved in limb bud formation
A ubiquitin ligase complex in which a cullin from the Cul8 subfamily and a RING domain protein form the catalytic core. In S. cerevisiae, Mms1p acts as the adaptor protein and substrate specificity is conferred by any of a number of different proteins.
Cul8-RING ubiquitin ligase complex
Binding to a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit.
chondroitin sulfate proteoglycan binding
Binding to chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc).
chondroitin sulfate binding
The directed movement of water (H2O) from one side of an epithelium to the other.
transepithelial water transport
Enables the transfer of carbon dioxide (CO2) from one side of a membrane to the other.
carbon dioxide transmembrane transporter activity
Catalysis of the reaction: L-ascorbate 6-phosphate + H2O = 3-keto-L-gulonate 6-phosphate.
L-ascorbate 6-phosphate lactonase activity
The establishment of the diencephalon with respect to the left and right halves.
determination of left/right asymmetry in diencephalon
Determination of the asymmetric location of the pancreas with respect to the left and right halves of the organism.
determination of pancreatic left/right asymmetry
Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.
positive regulation of vascular wound healing
Binding to a lipase.
lipase binding
Any process that modulates the frequency, rate or extent of angioblast cell migration involved in selective angioblast sprouting.
regulation of angioblast cell migration involved in selective angioblast sprouting
Binding to a chylomicron, a large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE.
chylomicron binding
The directed movement of angioblasts from the lateral mesoderm to the midline which occurs as part of the formation of the early midline vasculature.
angioblast cell migration from lateral mesoderm to midline
Any process that increases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response.
positive regulation of leukotriene production involved in inflammatory response
Any process that decreases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response.
negative regulation of leukotriene production involved in inflammatory response
The development of the portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter.
ureter part of ureteric bud development
Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity.
positive regulation of myosin light chain kinase activity
The removal of an alkyl group from one or more nucleotides within an DNA molecule.
DNA dealkylation
The removal of the methyl group from one or more nucleotides within an RNA molecule involving oxidation (i.e. electron loss) of one or more atoms.
oxidative RNA demethylation
The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles.
retrograde transport, plasma membrane to Golgi
Any process that increases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
positive regulation of SNARE complex disassembly
Any process that decreases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
negative regulation of SNARE complex disassembly
Any process that increases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
positive regulation of SNARE complex assembly
Any process that decreases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
negative regulation of SNARE complex assembly
A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide).
urease complex
The signaling process in which signaling from the receptor ROBO is brought to an end, rather than being reversibly modulated.
termination of Roundabout signal transduction
The dimethylation of the N-terminal serine of proteins to form the derivative N,N-dimethylserine.
N-terminal peptidyl-serine dimethylation
The trimethylation of the N-terminal serine of proteins to form the derivative N,N,N-trimethylserine.
N-terminal peptidyl-serine trimethylation
Catalysis of the methylthiolation (-SCH3 addition) of the beta-carbon of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid.
aspartic acid methylthiotransferase activity
The addition of a methylthioether group (-SCH3) to a nucleotide in a tRNA molecule.
tRNA methylthiolation
The removal of a branching point glutamate residue. A branching point glutamate connects a glutamate side chain to a gene-encoded glutamate residue.
protein branching point deglutamylation
The process in which a receptor is activated by another receptor. Receptor transactivation can occur through different mechanisms and includes cross-talk between signaling pathways where one receptor activates a receptor for a different ligand, and also activation of subunits within a receptor oligomer.
receptor transactivation
The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gallbladder to the common bile duct.
cystic duct development
A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules.
CD40 receptor complex
The specific movement from place to place of an organism in response to a novel environment.
locomotory exploration behavior
The process of removing one or more phosphate groups from a phosphorylated anandamide.
phosphoanandamide dephosphorylation
The directed movement of substances from endosomes to the melanosome, a specialised lysosome-related organelle.
endosome to melanosome transport
A complex that functions in transcription termination of RNA polymerase II transcribed non-coding RNAs. This complex interacts with the carboxy-terminal domain (CTD) of PolII and the terminator sequences in the nascent RNA transcript. In yeast this complex consists of Nrd1p, Nab3p, and Sen1p.
Nrd1 complex
Binding to an AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).
AP-1 adaptor complex binding
Binding to an AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B).
AP-3 adaptor complex binding
A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p.
Mon1-Ccz1 complex
The change in form (cell shape and size) that occurs when an anterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface.
anterior lateral line neuromast hair cell morphogenesis
The change in form (cell shape and size) that occurs when a posterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface.
posterior lateral line neuromast hair cell morphogenesis
A protein complex that binds macrophage migration inhibitory factor. Comprises CD74 and CD44 cell surface proteins.
macrophage migration inhibitory factor receptor complex
A protein complex comprising nitric oxide synthase 2 and CD74. This stable complex formation is thought to prevent CD74 degradation by caspases.
NOS2-CD74 complex
The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.
monocyte homeostasis
The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage.
common myeloid progenitor cell proliferation
The expansion of an activated CD4-positive, alpha-beta T cell population by cell division.
activated CD4-positive, alpha-beta T cell proliferation
The expansion of an activated CD8-positive, alpha-beta T cell population by cell division.
activated CD8-positive, alpha-beta T cell proliferation
The region of the myelin sheath furthest from the axon.
myelin sheath abaxonal region
The region of the myelin sheath nearest to the axon.
myelin sheath adaxonal region
Any process involved in sustaining the fidelity and copy number of DNA trinucleotide repeats. DNA trinucleotide repeats are naturally occurring runs of three base-pairs.
maintenance of DNA trinucleotide repeats
Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol), releasing phosphatidic acid (PA).
cardiolipin hydrolase activity
The binding of a mesangial cell to the extracellular matrix via adhesion molecules. A mesangial cell is a cell that encapsulates the capillaries and venules in the kidney.
mesangial cell-matrix adhesion
A developmental process, independent of morphogenetic (shape) change, that is required for the dorsal motor nucleus of the vagus nerve to attain its fully functional state.
dorsal motor nucleus of vagus nerve maturation
The orderly movement of a motor neuron precursor cell that contributes to formation of the dorsal motor nucleus of the vagus nerve.
motor neuron precursor migration involved in dorsal motor nucleus of vagus nerve formation
The process in which the anatomical structures of the pronephric glomerulus are generated and organized. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment.
pronephric glomerulus morphogenesis
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephric nephron tubule as it progresses from its formation to the mature state.
pronephric nephron tubule epithelial cell differentiation
A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut.
ureter maturation
Binds to and increases the activity of a deubiquitinase.
deubiquitinase activator activity
A protein complex that initiates the formation of double-strand breaks (DSBs) required for meiotic recombination. Consists of a protein that catalyses formation of the double-strand breaks (Spo11 in S. cerevisiae and Rec12 in S. pombe), and a number of accessory proteins.
meiotic recombination initiation complex
Any process where sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron, which contributes to decreasing the amount of sodium that is excreted in urine per unit time.
renal sodium ion absorption involved in negative regulation of renal sodium excretion
The process in which angiotensin decreases the amount of sodium that is excreted in urine over a unit of time.
negative regulation of renal sodium excretion by angiotensin
A gene conversion process in which a segment of about 50-200 base pairs is transferred from the donor to the acceptor.
short tract gene conversion
A gene conversion process in which a segment of more than 1000 base pairs is transferred from the donor to the acceptor.
long tract gene conversion
A membrane-bound structure present in the nucleus of a spermatozoon. There is variation in the number of endonuclear canals between sperm of different organisms, and some species lack these structures altogether. The endonuclear canal may provide a supporting role for the sperm nucleus, and originates during spermiogenesis from an invagination of the nuclear envelope.
endonuclear canal
The process in which the nephric duct grows along its axis. A nephric duct is a tube that drains a primitive kidney.
nephric duct elongation
A protein complex that consists of an alphav-beta3 integrin complex bound to insulin-like growth factor-1 (IGF-1) and type I insulin-like growth factor receptor (IGF1R). IGF1R is a heterotetramer that consists of two alpha-subunits and two beta-subunits.
alphav-beta3 integrin-IGF-1-IGF1R complex
The process, occurring in the embryo, by which the anatomical structures of a nail plate are generated and organized. The nail plate is the hard and translucent portion of the nail, composed of keratin, and serves to protect the tips of digits.
embryonic nail plate morphogenesis
The chemical reactions and pathways resulting in the formation of arabinan, a polysaccharide composed of arabinose residues.
arabinan biosynthetic process
Catalysis of the hydrolysis of terminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, exochitinases progressively cleave off two subunits from the reducing or non-reducing ends of the chitin chain.
exochitinase activity
The attachment of a developing otolith to the kinocilia of tether cells in the inner ear.
otolith tethering
The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.
ascending aorta morphogenesis
The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once.
descending aorta morphogenesis
The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.
dorsal aorta morphogenesis
The process in which the anatomical structures of the ventral aorta are generated and organized. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once.
ventral aorta morphogenesis
The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
perforin production