NothingMuch/GO-Terms huggingface dataset:
The basement membrane constituent secretion in which there is a restriction or targeting of basement membrane proteins for controlled release on the basal side of polarized epithelium.
polarized secretion of basement membrane proteins in epithelium
The mitotic spindle organization process by which a mitotic spindle becomes asymmetric either in position or structure.
establishment of mitotic spindle asymmetry
Any process that increases the frequency, rate or extent of hepatic stellate cell migration.
positive regulation of hepatic stellate cell migration
Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell migration.
negative regulation of hepatic stellate cell migration
Any process that activates or increases the frequency, rate or extent of hepatic stellate cell contraction.
positive regulation of hepatic stellate cell contraction
Any process that modulates stops, prevents, or reduces the frequency, rate or extent of hepatic stellate cell contraction.
negative regulation of hepatic stellate cell contraction
Any process that increases the frequency, rate or extent of mini excitatory postsynaptic potential. Mini excitatory postsynaptic potential is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse.
positive regulation of mini excitatory postsynaptic potential
Any process that decreases the frequency, rate or extent of mini excitatory postsynaptic potential. Mini excitatory postsynaptic potential is a process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell, induced by the spontaneous release of a single vesicle of an excitatory neurotransmitter into the synapse.
negative regulation of mini excitatory postsynaptic potential
Any process that decreases the frequency, rate or extent of astrocyte activation.
negative regulation of astrocyte activation
Any process that increases the frequency, rate or extent of astrocyte activation.
positive regulation of astrocyte activation
Binding to and responding, e.g. by conformational change, to changes in the cellular level of calcium ions (Ca2+).
calcium ion sensor activity
Catalysis of the reaction: all-trans-retinol + 2 H+ + O2 + 2 reduced  = all-trans-3,4-didehydro retinol + 2 H2O + 2 oxidized .
all-trans retinol 3,4-desaturase activity
Catalysis of the reaction: all-trans-retinal + 2 H+ + O2 + 2 reduced  = all-trans-3,4-didehydro retinal + 2 H2O + 2 oxidized .
all-trans retinal 3,4-desaturase activity
Catalysis of the reaction: all-trans-retinoic acid + 2 H+ + O2 + 2 reduced  = all-trans-3,4-didehydro retinoic acid + 2 H2O + 2 oxidized .
all-trans retinoic acid 3,4-desaturase activity
Catalysis of the reaction: 11-cis-retinal + 2 H+ + O2 + 2 reduced  = 11-cis-3,4-didehydro-retinal + 2 H2O + 2 oxidized .
11-cis-retinal 3,4-desaturase activity
Any process that stops, prevents or reduces the frequency, rate or extent of AMPA glutamate receptor activity.
negative regulation of AMPA receptor activity
The process in which an autophagosome fuses with an endosome to create an intermediate autophagic organelle called amphisome.
autophagosome-endosome fusion
The process in which amphisomes fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole. Fusion provides an acidic environment and digestive function to the interior of the amphisome.
amphisome-lysosome fusion
Any process that increases the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.
positive regulation of growth plate cartilage chondrocyte proliferation
Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.
negative regulation of growth plate cartilage chondrocyte proliferation
The propionylation of peptidyl-lysine.
peptidyl-lysine propionylation
The protein transport macromolecular complex of the chloroplast membrane that interacts with the precursor proteins and contains components of both the outer membrane and inner membrane complexes containing at least Toc75, Toc159, Toc34 and Tic110.
TOC-TIC supercomplex I
Catalysis of the reaction: glutathione = 5-oxoproline + L-cysteinylglycine.
glutathione specific gamma-glutamylcyclotransferase activity
Catalysis of the reaction: epsilon-(L-gamma-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline.
gamma-glutamylaminecyclotransferase activity
Any process that increases the frequency, rate or extent of erythrocyte enucleation.
positive regulation of erythrocyte enucleation
Any process that decreases the frequency, rate or extent of erythrocyte enucleation.
negative regulation of erythrocyte enucleation
Any process that modulates the frequency, rate or extent of an adenine biosynthetic process.
regulation of adenine biosynthetic process
The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of double fertilization forming two zygotes.
fusion of sperm to egg plasma membrane involved in double fertilization forming two zygotes
Any process that increases the rate, frequency or extent of c-di-GMP signaling.
positive regulation of c-di-GMP signaling
Any process that decreases the rate, frequency or extent of c-di-GMP signaling.
negative regulation of c-di-GMP signaling
Any process that stops, prevents or reduces the frequency, rate or extent of K48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
negative regulation of protein K48-linked ubiquitination
Catalysis of the reaction: S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine in mRNA.
mRNA (adenine-N1-)-methyltransferase activity
A protein complex that is capable of contributing to protein localization by the NVT pathway. In fission yeast, the Nvt complex consists of Ape2, Lap2 and Nbr1.
NVT complex
Any process that modulates the frequency, or rate of heme oxygenase activity.
regulation of heme oxygenase activity
Any process that stops, prevents, or reduces the frequency, rate or extent of the dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli.
negative regulation of entry into reproductive diapause
Any process that activates or increases the rate or extent of the dormancy process that results in entry into reproductive diapause. Reproductive diapause is a form of diapause where the organism itself will remain fully active, including feeding and other routine activities, but the reproductive organs experience a tissue-specific reduction in metabolism, with characteristic triggering and releasing stimuli.
positive regulation of entry into reproductive diapause
The initial formation of the type asymmetry in an organism's body plan or part of an organism that established the pattern characteristic to its left side.
establishment of left sidedness
The organization process that preserves the left sidedness in an organism's body plan or part of an organism with respect to the left and right halves.
maintenance of left sidedness
The organization process that preserves the right sidedness in an organism's body plan or part of an organism with respect to the left and right halves.
maintenance of right sidedness
The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone.
replacement bone morphogenesis
The process in which bone which forms superficially in the organism are generated and organized.
dermal bone morphogenesis
The process in which bones are generated and organized as a result of the conversion of initial connective tissue surrounding cartilage into bone.
perichondral bone morphogenesis
The process whose specific outcome is the progression of mandibular joint condyle articular cartilage over time, from its formation to the mature structure.
mandibular condyle articular cartilage development
The process whose specific outcome is the progression of femoral head articular cartilage over time, from its formation to the mature structure.
femoral head articular cartilage development
The chromosome organization process in which meiotic chromosomes in the spem nucleus cluster together to form a compact spherical structure called the karyosome.
sperm karyosome formation
Catalysis of the reaction: octanoyl-CoA + H+ + malonyl- = 3-oxodecanoyl- + CO2 + CoA.
beta-ketodecanoyl- synthase activity
Any process that activates or increases the frequency, rate or extent of cardiac endothelial to mesenchymal trnasition.
positive regulation of cardiac endothelial to mesenchymal transition
Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac endothelial to mesenchymal transition.
negative regulation of cardiac endothelial to mesenchymal transition
Any process that decreases the frequency or rate of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity.
negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
The biological process whose specific outcome is the progression of the primitive palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure.
primitive palate development
Any process that stops or decreases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process
Any process that starts or increases the rate, frequency or extent of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.
positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process
Any process that starts or increases the rate, frequency or extent of stress-granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
positive regulation of stress granule assembly
Any process that stops or decreases the rate, frequency or extent of stress-granule assembly, the aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
negative regulation of stress granule assembly
A MAPK cascade containing at least the Kss1 MAP kinase. It starts with the activation of Ste20, a MAP4K, which activates Ste11, a MAP3K, which in turn activate Ste7, a MAP2K, which activates Kss1. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The filamentous growth MAPK cascade is activated as a result of partial nutrient deprivation and  results in filamentous growth.
filamentous growth MAPK cascade
Any process that activates or increases the frequency, rate or extent of a pheromone response MAPK cascade.
positive regulation of pheromone response MAPK cascade
An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.
fungal biofilm matrix
Any process that increases the rate or extent of meiotic sister chromatid arm separation, the cell cycle process in which sister chromatid arms are physically detached from each other during meiosis.
positive regulation of meiotic sister chromatid arm separation
Catalysis of the reaction: L-lysine + pyruvate= epsilon-amino-alpha-ketocaproic acid (KAC) + alanine.
L-lysine alpha-aminotransferase
Catalysis of the reaction: dehydropipecolic acid + NAD(P)H + H+ = L-pipecolic acid + NAD(P)+.
dehydropipecolic acid reductase
Catalysis of the reaction: L-pipecolic acid + NAD(P)H + O2 + H+ = N-hydroxypipecolic acid + NAD(P)+ + H2O.
pipecolic acid N-hydroxylase
A protein-containing complex that inhibits protein phosphatase activity by directly binding to a protein phosphatase.
protein phosphatase inhibitor complex
A phosphoric diester hydrolase activity that removes the ethanolamine phosphate from mannose 2 of a GPI anchor.
GPI-mannose ethanolamine phosphate phosphodiesterase activity
A protein-containing complex that functions to transport lipopolysaccharide from its site of synthesis at the cytoplasmic membrane across the periplasm to the outer membrane in an ATP-dependent manner.
lipopolysaccharide transport system
The sequence of events that initiates (or primes) the synthesis of semi-crystalline starch granules within photosynthetic chloroplasts or non-photosynthetic amyloplasts.
starch granule initiation
Enables the energy-independent facilitated diffusion of a fluoride ion through a transmembrane aqueous pore or channel.
fluoride channel activity
A regulation of the phtosynthetic light reaction in which the light harvesting antenna complexes transition between photosystems.
photosynthetic state transition
The process in which a relatively unspecialized cell acquires the specialized features of a compound eye pigment cell, a cell of the retina containing screening pigments that functions to screen photoreceptors from light leaking from adjacent ommatidia.
compound eye pigment cell differentiation
Enables the transport of L-aspartate and fumarate across a membrane according to the reaction L-aspartate (out) + fumarate (in) = L-aspartate (in) + fumarate (out).
L-aspartate:fumarate antiporter activity
Binding to a transcription factor TFIIH holo complex.
transcription factor TFIIH holo complex binding
Binding to a FACT complex.
FACT complex binding
Binding to a NuA4 histone acetyltransferase complex.
NuA4 histone acetyltransferase complex binding
Binding to a TAP complex.
TAP complex binding
Binding to an oligosaccharyltransferase complex.
oligosaccharyltransferase complex binding
Binding to a BBSome complex.
BBSome binding
Binding to a box C/D methylation guide snoRNP complex.
box C/D methylation guide snoRNP complex binding
Binding to a box H/ACA snoRNP complex.
box H/ACA snoRNP complex binding
Binding to a PSII associated light-harvesting complex II.
PSII associated light-harvesting complex II binding
Binding to a chloroplast photosystem I.
chloroplast photosystem I binding
Binding to a chloroplast photosystem II.
chloroplast photosystem II binding
Binding to a GARP complex.
GARP complex binding
Binding to a SAGA complex.
SAGA complex binding
A transcription factor complex composed of a homeodomain protein and the M-specific peptide Mi that acts at the regulatory region of genes required for the activation of meiosis.
Pi Mi complex
Binding to a histone H3 in which the lysine residue at position 9 has been modified by trimethylation.
H3K9me3 modified histone binding
An area where exine is reduced or absent, in the pollen wall.
pollen aperture
The cellular component assembly process of forming pollen apertures, areas where exine is reduced or absent, in the pollen cell wall.
pollen aperture formation
A protein complex essential for autophagy during nutrient deprivation, a catabolic process that sequesters undesired cellular material into autophagosomes for delivery to lysosomes for degradation. Contributes to nutrition homeostasis and damage control in eukaryotic cells. Functions at a late step of autophagosome formation for efficient completion of sequestration, probably through facilitating recruitment of ATG8-phosphatidylethanolamine (PE) to the preautophagosomal structure (PAS) and/or its protection from deconjugation by ATG4. Composed of ATG2 and ATG18 in Saccharomyces cerevisiae.
ATG2-ATG18 complex
Combining with a MHC class Ib protein complex to mediate signaling that activates a lymphocyte.
activating MHC class Ib receptor activity
Combining with a MHC class Ib molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte.
HLA-E specific inhibitory MHC class Ib receptor activity
Combining with a MHC class Ib molecule of the HLA-G subclass to mediate signaling that inhibits activation of a lymphocyte.
HLA-G specific inhibitory MHC class Ib receptor activity
Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi.
positive regulation of capsule polysaccharide biosynthetic process
Any process that increases the frequency, rate or extent of vein smooth muscle contraction.
positive regulation of vein smooth muscle contraction
Any process that decreases the frequency, rate or extent of vein smooth muscle contraction.
negative regulation of vein smooth muscle contraction
Any process that activates or increases the frequency, rate or extent of taurine biosynthesis.
positive regulation of taurine biosynthetic process
A cytosolic complex that functions as an substrate-specific adaptor, linking the cytosolic iron-sulfur protein assembly (CIA) targeting complex to apo-Rli1p, an ABC protein involved in ribosome recycling, facilitating Fe-S cluster insertion and the maturation of the Rli1p.
Yae1-Lto1 complex
The selective autophagy process in which a damaged lysosome is degraded by macroautophagy.
lysophagy
The attachment of an endoplasmic reticulum membrane to a peroxisome via molecular tethers that physically bridge the two membranes and attach them to each other.
endoplasmic reticulum-peroxisome tethering
The disaggregation of a kinetochore into its constituent components.
kinetochore disassembly
The cellular metabolic process in which organic chemical compounds are synthesized from carbon-containing molecules and nutrients using energy obtained from the oxidation of inorganic compounds or methane.
chemosynthesis
Division of a female germline stem cell to produce two germline stem cells of the same type as the parent.
female germline stem cell symmetric division
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to a non-growing cell tip.
negative regulation of protein localization to non-growing cell tip
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA recombinase complex disassembly, the disaggregation of a DNA recombinase complex into its constituent components.
negative regulation of DNA recombinase disassembly
A chloroplast-derived plastid in which the solid form of phenol is stored.
phenyloplast
A protein complex that associates with chromatin to form linear elements in fission yeast. In S. pombe, the LinE complex contains four main structural components (Rec10, Rec25, Rec27, and Mug20) and other associated proteins.
LinE complex
The aggregation, arrangement and bonding together of a set of components during meiotic prophase to form a LinE complex, the protein complex that associates with chromatin to form linear elements in fission yeast. In S. pombe, the LinE complex contains four main structural components (Rec10, Rec25, Rec27, and Mug20) and other associated proteins.
LinE complex assembly
Any process that modulates the rate, frequency or extent of linear element maturation.
regulation of linear element maturation
Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamine biosynthesis.
negative regulation of L-glutamine biosynthetic process
Any process that starts, increases the frequency, rate or extent of L-glutamine biosynthesis.
positive regulation of L-glutamine biosynthetic process
The process whose specific outcome is the progression of a light-responsive receptor in a camera-type eye over time, from its formation to the mature structure.
camera-type eye photoreceptor cell development
The chemical reactions and pathways resulting in the formation of L-beta-ethynylserine. L-beta-ethynylserine is an antibiotic produced by Streptomyces bacteria.
L-beta-ethynylserine biosynthetic process
The chemical reactions and pathways resulting in the formation of L-propargylglycine (Pra). L-propargylglycine is an antibiotic produced by Streptomyces bacteria.
L-propargylglycine biosynthetic process
Catalysis of the reaction: L-2-amino-4-chloropent-4-enoate = chloride + H+ + L-propargylglycine.
L-propargylglycine synthase activity
Catalysis of the reaction: ATP + L-glutamate + L-propargylglycine = ADP + H+ + L-gamma-glutamyl-L-propargylglycine + phosphate.
L-propargylglycine--L-glutamate ligase activity
Catalysis of the reaction: 4-chloro-L-lysine + AH2 + O2 = A + formaldehyde + H2O + L-2-amino-4-chloropent-4-enoate + NH4(+).
4-chloro-allylglycine synthase activity
Catalysis of the reaction: 2-oxoglutarate + chloride + H+ + L-lysine + O2 = 4-chloro-L-lysine + CO2 + H2O + succinate.
L-lysine 4-chlorinase activity
Catalysis of the reaction: 2-oxoglutarate + L-gamma-glutamyl-L-propargylglycine + O2 = CO2 + L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate.
L-gamma-glutamyl-L-propargylglycine hydroxylase activity
Catalysis of the reaction:(+)-amorpha-4,11-diene + 3 O2 + 3 reduced  = (+)-artemisinate + 4 H+ + 4 H2O + 3 oxidized .
amorpha-4,11-diene 12-monooxygenase activity
A protein-containing complex that is capable of catalase activity.
catalase complex
A protein-containing complex that serves as a channel for the secretion of curli. Curli are a fibers that serve as a major component of the extracellular matrix of pellicle biofilms.
curli secretion complex
A protein-containing complex that is capable of the ATP-dependent diffusion of a potassium ion across the mitochondrial inner membrane.
mitochondrial ATP-gated potassium channel complex
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(out) + proton(in) = chloride(in) + proton(out).
chloride:proton antiporter activity
A cellular anatomical entity which is a network of tubules and vessicles and is part of the contractile vacuole complex. It is involved in the discharge of water externally. One of its functions is osmoregulatory.
spongiome
Any process that increases the rate, frequency or extent of pseudohyphal septin ring formation.
positive regulation of pseudohyphal septin ring assembly
Any process that decreases the rate, frequency or extent of pseudohyphal septin ring assembly.
negative regulation of pseudohyphal septin ring assembly
Any process that stops, prevents, or reduces the frequency, rate, or extent of plus-end directed microtubule sliding.
negative regulation of plus-end directed microtubule sliding
The aggregation, arrangement and bonding together of a set of components to form the radial spoke, a protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules.
radial spoke assembly
Catalysis of the reaction: calcidiol + 2 H+ + O2 + 2 reduced  = (23S)-23,25-dihydroxycalciol + H2O + 2 oxidized .
25-hydroxycholecalciferol-23-hydroxylase activity
Catatlysis of the reaction: calcitriol + 2 H+ + O2 + 2 reduced  = 1alpha,23S,25-trihydroxycholecalciferol + H2O + 2 oxidized .
1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity