NothingMuch/GO-Terms huggingface dataset:
An active host response phase of acute inflammation driven by specialized pro-resolving mediators (SPMs) and signaling pathways, enabling timely tissue regeneration and return of function.
resolution phase response
Catalysis of the reaction: O2 + progesterone + reduced  = 21-hydroxyprogesterone + H+ + H2O + oxidized .
progesterone 21-hydroxylase activity
Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD+ = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADH + H+.
methylenetetrahydrofolate reductase (NADH) activity
Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP+ = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H+.
methylenetetrahydrofolate reductase (NADPH) activity
Catalysis of the reaction: ammonium hydroxide + 3 NAD+ + H2O = nitrite + 3 NADH + 3 H+.
nitrite reductase NADH activity
Catalysis of the reaction: S-(hydroxymethyl)glutathione + NADP+ = S-formylglutathione + NADPH + H+.
S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity
Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD+ = S-formylglutathione + NADH + H+.
S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity
Catalysis of the reaction: H2O + L-phenylalanine + O2 = 3-phenylpyruvate + H2O2 + NH4(+).
L-phenylalaine oxidase activity
Catalysis of the reaction: H2O + N-acetyl-9-O-acetylneuraminate = acetate + H+ + N-acetylneuraminate.
sialate 9-O-acetylesterase activity
Catalysis of the reaction: H2O + N-acetyl-4-O-acetylneuraminate = acetate + H+ + N-acetylneuraminate.
sialate 4-O-acetylesterase activity
Catalysis of the endonucleolytic cleavage of double-stranded DNA near a double-strand/single-strand DNA junction.
ds/ssDNA junction-specific dsDNA endonuclease activity
Catalysis of the reaction: 5-(carboxymethyl)uridine34 in tRNA + S-adenosyl-L-methionine = 5-(2-methoxy-2-oxoethyl)uridine34 in tRNA + S-adenosyl-L-homocysteine.
tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity
Catalysis of the reaction: 1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + N-(30-hydroxytriacontanoyl)-sphing-4-enine = di-(9Z,12Z)-octadecadienoylglycerol + N--sphing-4-enine.
omega-hydroxyceramide transacylase activity
The chemical reactions and pathways resulting in the formation of omega-hydroxyceramide/acylceramide.
omega-hydroxyceramide biosynthetic process
Catalysis of the reaction glutarate + 2-oxoglutarate + O2 = (S)-2-hydroxyglutarate + succinate + CO2.
glutarate dioxygenase activity
Catalysis of the reaction: 2 Fe(3+) + 4 H2O + L-histidyl- + N(6)-(pyridoxal phosphate)-L-lysyl- = (2S)-2-amino-5-hydroxy-4-oxopentanoyl- + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H+ + L-lysyl-.
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP
Catalysis of the reaction: a 2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-2'-O-methyladenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+.
U2 snRNA 2'-O-methyladenosine m6 methyltransferase activity
Catalysis of the reaction: a adenosine in U2 snRNA + S-adenosyl-L-methionine = an N6-methyl-adenosine in U2 snRNA + S-adenosyl-L-homocysteine + H+.
U2 snRNA adenosine m6 methyltransferase activity
Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate.
octaprenyl pyrophosphate synthase activity
Catalysis of the reaction: 4-hydroxybenzoate + H+ + NADH + O2 = 3,4-dihydroxybenzoate + H2O + NAD+.
4-hydroxybenzoate 3-monooxygenase (NADH) activity
Catalysis of the reaction: dTDP-beta-L-rhamnose + L-arginyl- = dTDP + H+ + N(omega)-(L-rhamnosyl)-L-arginyl-.
protein-arginine rhamnosyltransferase activity
Catalysis of the reaction: L-arginyl- + UDP-N-acetyl-alpha-D-glucosamine = H+ + N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl- + UDP.
protein-arginine N-acetylglucosaminyltransferase activity
4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 H+ + O2 + 2 reduced - = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + H2O + 2 oxidized -.
4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity
Catalyzes the reaction: all-trans-beta-carotene = 9-cis-beta-carotene.
beta-carotene isomerase activity
Catalysis of the reaction: ATP + guanosine = ADP + GMP.
guanosine kinase activity
Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dGTP = a 2'-deoxyribonucleoside 5'-diphosphate + dGDP.
(deoxy)nucleoside phosphate kinase activity, dGTP as phosphate donor
Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + dTTP = a 2'-deoxyribonucleoside 5'-diphosphate + dTDP.
(deoxy)nucleoside phosphate kinase activity, dTTP as phosphate donor
Catalysis of the reaction: a 2'-deoxyribonucleoside 5'-phosphate + GTP = a 2'-deoxyribonucleoside 5'-diphosphate + GDP.
(deoxy)nucleoside phosphate kinase activity, GTP as phosphate donor
Catalysis of the reaction: L-histidyl- + S-adenosyl-L-methionine = N(pros)-methyl-L-histidyl- + S-adenosyl-L-homocysteine.
protein-L-histidine N-pros-methyltransferase activity
Catalysis of the reaction: O2 + primary fluorescent chlorophyll catabolite + reduced  = formate + 2 H+ + oxidized  + primary fluorescent dioxobilin-type chlorophyll catabolite.
fluorescent chlorophyll catabolite monooxygenase (deformylase) activity
Catalysis of the reaction: H2O + primary fluorescent dioxobilin-type chlorophyll catabolite = H+ + methanol + O13(4)-desmethyl pFCC.
primary fluorescent dioxobilin-type chlorophyll catabolite methylesterase activity
Catalysis of the reaction: 3-deoxyglucosone + H2O + NAD+ = 2-dehydro-3-deoxy-D-gluconate + 2 H+ + NADH.
3-deoxyglucosone dehydrogenase activity
Catalysis of the reaction: dNTP + H2O = 2'-deoxynucleoside + H+ + triphosphate.
deoxynucleoside triphosphate hydrolase activity
Catalysis of the reaction: 2-hydroxyphytanoyl-CoA = 2,6,10,14-tetramethylpentadecanal + formyl-CoA.
2-hydroxyphytanoyl-CoA lyase activity
Catalysis of the reaction: 2-hydroxy-ATP + H2O = 2-hydroxy-AMP + H+ + diphosphate.
2-hydroxy-ATP hydrolase activity
Catalysis of the reaction: 2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + H+ + diphosphate.
2-hydroxy-dATP hydrolase activity
Catalysis of the reaction: 8-oxo-(d)RTP + H20 = 8-oxo-(d)RMP + diphosphate + H+.
8-oxo-(d)RTP hydrolase activity
Any process which produces a dAMP from derivatives of it, without de novo synthesis.
dAMP salvage
Any process which produces a dGMP from derivatives of it, without de novo synthesis.
dGMP salvage
Any process which produces a dIMP from derivatives of it, without de novo synthesis.
dIMP salvage
Catalysis of the reaction: N1-methylpseudouridine in 18S rRNA + S-adenosyl-L-methionine = H+ + N1-methyl-N3-pseudouridine in 18S rRNA + S-methyl-5'-thioadenosine.
18S rRNA aminocarboxypropyltransferase activity
A protein complex required for the splicing of intron 4 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI4 (which derives from one of the products of the splicing), Leucyl-tRNA synthetase NAM2 and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autoctalyse a group I intron splicing.
bI4 intron splicing complex
Aprotein complex required for the splicing of intron 3 of the cytochrome b (COB) gene. In S. cerevisiae, the complex contains the maturase bI3 (which derives from one of the products of the splicing), the MRS1 cofactor and the intron 4 of the cytochrome b pre-mRNA. The two proteins stimulate the ribozyme activity of the pre-mRNA which autoctalyse a group I intron splicing.
bI3 intron splicing complex
Any process that stops, prevents or reduces the frequency, rate or extent of a palmitic acid catabolic process.
negative regulation of palmitic acid catabolic process
Any process that activates or increases the frequency, rate or extent of a palmitic acid catabolic process.
positive regulation of palmitic acid catabolic process
Any process that activates or increases the frequency, rate or extent of R7 cell fate commitment.
positive regulation of R7 cell fate commitment
Any process that stops, prevents or reduces the frequency, rate or extent of R7 cell fate commitment.
negative regulation of R7 cell fate commitment
A mechanism of homologous recombination and DNA repair in which transcript RNA is used as a template for DSB repair.
double-strand break repair via transcription-associated homologous recombination
Catalysis of the dephosphorylation of isoprenoid diphosphates.
isoprenoid diphosphate phosphatase activity
Catalysis of the reaction: 3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'-5')-adenosine + H+.
cyclic-di-AMP phosphodiesterase activity
Any process involved in forming the mature 5' end of a box C/D RNA molecule.
box C/D sno(s)RNA 5'-end processing
Catalysis of the reaction: 5'XMP + H20 = phosphate + xanthosine.
XMP 5'-nucleosidase activity
Catalysis of the reaction: mRNA-uracil + NAD(P)+ = mRNA-dihydrouridine + NAD(P)H+ + H+.
mRNA dihydrouridine synthase activity
GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelyl-D-alanine + H2O = GlcNAc-MurNAc-L-alanyl-gamma-D-glutamyl-meso-diaminopimelate + D-alanine.
muramoyltetrapeptide carboxypeptidase activity
Catalysis of the reaction: dopaminechrome = 5,6-dihydroxyindole.
dopaminechrome tautomerase activity
Catalysis of the reaction: (R)-N6-lipoyl-L-lysyl- + H2O + NAD+ = 2''-O-lipoyl-ADP-D-ribose + L-lysyl- + nicotinamide.
NAD-dependent protein lipoamidase activity
Catalysis of the reaction: H2O + N6-biotinyl-L-lysyl- + NAD+ = 2''-O-biotinyl-ADP-D-ribose + L-lysyl- + nicotinamide.
NAD-dependent protein biotinidase activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-glutamate(out) + H+(in) = L-glutamate(in) + H+(out).
L-glutamate:proton antiporter activity
Catalysis of the reaction: Zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal.
carotenoid isomerooxygenase activity
Any process that stops, prevents or reduces the frequency, rate or extent of the kainate selective glutamate receptor signaling pathway.
negative regulation of kainate selective glutamate receptor signaling pathway
Any process that activates or increases the frequency, rate or extent of the kainate selective glutamate receptor signaling pathway.
positive regulation of kainate selective glutamate receptor signaling pathway
Catalysis of the reaction:11-cis-retinol- + NAD+ = 11-cis-retinal- + NADH.
11-cis-retinol dehydrogenase
(S)-dihydroorotate + a quinone = orotate + a quinol.
dihydroorotate dehydrogenase (quinone) activity
Catalysis of the reaction N6-methyl-(d)ATP + H2O = N6-methyl-(d)AMP + diphosphate + H+.
N6-methyl-(d)ATP hydrolase activity
Catalysis of the reaction O6-methyl-dGTP + H2O = O6-methyl-dGMP + diphosphate + H+.
O6-methyl-dGTP hydrolase activity
The reactions involved in isomerization of all trans to all cis retnal.
retinal isomerization
Catalytic reaction: ATP + L-glutamate + L-glutamyl- = ADP + H+ + L-gamma-glutamyl-L-glutamyl- + phosphate.
protein-glutamic acid ligase activity, initiating
Catalytic reaction :(L-glutamyl)n-L-gamma-glutamyl-L-glutamyl- + ATP + L-glutamate = (L-glutamyl)n+1-L-gamma-glutamyl-L-glutamyl- + ADP + H+ + phosphate.
protein-glutamic acid ligase activity, elongating
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out).
L-lysine:L-arginine antiporter activity
A bacterial protein complex that neutralises its own toxin by complexing the toxin with the antitoxin. The antitoxin can be either a protein or an RNA. The neutralising toxin-antitoxin complex also acts as a transcriptional repressor of the toxin-antitoxin operon.
toxin-antitoxin complex
Any process that activates or increases the frequency, rate or extent of tRNA C5-cytosine methylation.
positive regulation of tRNA C5-cytosine methylation
The controlled release of proteins from a cell at the sides which interface adjacent cells and near the base.
basolateral protein secretion
Any process that increases the frequency, rate or extent of aggregation involved in sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.
positive regulation of aggregation involved in sorocarp development
Any process that decreases the frequency, rate or extent of aggregation involved in sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.
negative regulation of aggregation involved in sorocarp development
Any process that activates or increases the frequency, rate or extent of elastin catabolism, the chemical reactions and pathways resulting in the breakdown of elastin.
positive regulation of elastin catabolic process
A chromatin remodeling complex that positively regulates histone H3 acetylation, in particular H3K9, by recruiting histone acetyltransferases to rDNA gene regions. Located in the nucleolus where it assembles on RNA Polymerase I (Pol I) and possibly on RNA Polymerase III (Pol III) promoter and coding regions during early G1 phase and activates the post-initiation phases of Pol I transcription. May also activate RNA Polymerase II (Pol II) gene transcription. In mammals, B-WICH contains the WICH complex core of BAZ1B and SMARCA5, additional protein subunits and possibly rRNAs. Although it contains several catalytic subunits it is not clear which functions are carried out by the complex itself.
B-WICH complex
Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation.
negative regulation of cardiac muscle myoblast proliferation
Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation.
positive regulation of cardiac muscle myoblast proliferation
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA strand resection involved in replication fork processing.
negative regulation of DNA strand resection involved in replication fork processing
Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle.
positive regulation of G2/MI transition of meiotic cell cycle
The activity of binding selectively, and in a sequence-specific manner, a replication fork barrier found in rDNA spacers, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
rDNA spacer replication fork barrier binding, bending
Binding to the C2 domain of a protein, a protein structural domain involved in targeting proteins to cell membranes.
C2 domain binding
Any process that stops, prevents, or reduces the frequency, rate or extent of nematode male tail tip morphogenesis.
negative regulation of nematode male tail tip morphogenesis
Any process that activates or increases the frequency, rate or extent of nematode male tail tip morphogenesis.
positive regulation of nematode male tail tip morphogenesis
Any process that stops, prevents, or reduces the frequency, rate or extent of nematode pharynx morphogenesis.
negative regulation of nematode pharynx morphogenesis
Any process that activates or increases the frequency, rate or extent of nematode pharynx morphogenesis.
positive regulation of nematode pharynx morphogenesis
Any process that stops, prevents, or reduces the frequency, rate, or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division.
negative regulation of cell cycle switching, mitotic to meiotic cell cycle
Catalysis of the reaction: N-(4-oxoglutarate)-L-cysteinylglycine + H2O = 2-oxoglutarate + L-cysteinylglycine.
deaminated glutathione amidase activity
A cellular process that, through single- or multi-step enzymatic reactions, repairs toxic endogenous compounds, formed as by-products of primary metabolism, by converting them into useful metabolites.
toxic metabolite repair
Any process that stops, prevents or reduces the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments.
negative regulation of actin filament annealing
Any process that activates or increases the frequency, rate or extent of actin filament annealing, i.e. the end-to-end joining of existing actin filaments.
positive regulation of actin filament annealing
Any process that stops, prevents, or reduces the frequency, rate or extent of the angiotensin-activated signaling pathway.
negative regulation of angiotensin-activated signaling pathway
Any process that activates or increases the frequency, rate or extent of the angiotensin-activated signaling pathway.
positive regulation of angiotensin-activated signaling pathway
Catalysis of the reaction: glucosylglycerate + phosphate = glucose-1-phosphate + D-glycerate.
glucosylglycerate phosphorylase activity
The separation of a syncytial embryo into individual cells.
syncytial embryo cellularization
The base of the cellularization invagination or cleavage furrow most distal to the original multi-nucleate cell or syncytium plasma membrane.
cellularization cleavage furrow invagination front
Any process that activates or increases the frequency, rate or extent of apical constriction involved in ventral furrow formation.
positive regulation of apical constriction involved in ventral furrow formation
Any process that stops, prevents, or reduces the frequency, rate or extent of ferroptosis.
negative regulation of ferroptosis
Any process that activates or increases the frequency, rate or extent of placenta blood vessel development.
positive regulation of placenta blood vessel development
Any process that stops, prevents or reduces the frequency, rate or extent of placenta blood vessel development.
negative regulation of placenta blood vessel development
Any process that activates or increases the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly.
positive regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly
Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly.
negative regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons.
positive regulation of hippocampal neuron apoptotic process
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in hippocampal neurons.
negative regulation of hippocampal neuron apoptotic process
The area of a motile nucleus furthest from the direction of movement.
nucleus lagging edge
Any process that activates or increases the frequency, rate or extent of calcium import into the mitochondrion.
positive regulation of calcium import into the mitochondrion
Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import into the mitochondrion.
negative regulation of calcium import into the mitochondrion
The directed movement of L-valine into the vacuole across the vacuolar membrane.
L-valine transmembrane import into vacuole
The aggregation, arrangement and bonding together of a set of components to form the mRNA cleavage and polyadenylation specificity factor complex.
mRNA cleavage and polyadenylation specificity factor complex assembly
Any process that activates or increases the frequency, rate or extent of imaginal disc-derived wing vein specification.
positive regulation of imaginal disc-derived wing vein specification
Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc-derived wing vein specification.
negative regulation of imaginal disc-derived wing vein specification
Any process that increases the frequency, rate or extent of very-low-density lipoprotein particle clearance.
positive regulation of very-low-density lipoprotein particle clearance
Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at the nuclear side of the mitotic spindle pole body.
gamma-tubulin complex localization to nuclear side of mitotic spindle pole body
Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at the cytoplasmic side of the mitotic spindle pole body.
gamma-tubulin complex localization to cytoplasmic side of mitotic spindle pole body
Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration.
positive regulation of myotube cell migration
Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration.
negative regulation of myotube cell migration
The process of unloading sucrose that is produced in the source tissues, from the sieve tube or companion cell of the phloem into the sink tissues.
phloem sucrose unloading
Catalysis of the reaction: ribitol-5-phosphate + H20 = ribitol + phosphate.
ribitol-5-phosphatase activity
A biological process that results in the unequal transmission of alleles, haplotypes, or chromosomes from a parental genome to gametes. In the absence of meiotic drive, the two copies of each gene or chromosome in a diploid organism are transmitted to offspring with equal probability, whereas meiotic drive results in overrepresentation of the driving allele among the surviving products of meiosis.
meiotic drive
The series of molecular signals initiated by binding of the cysteine knot protein Norrin to a Frizzled 4 (Fzd4) family receptor on the surface of the target cell and ending with a change in cell state.
Norrin signaling pathway
Any process that activates or increases the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis.
positive regulation of imaginal disc-derived leg joint morphogenesis
Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis.
negative regulation of imaginal disc-derived leg joint morphogenesis
The process in which L-glutamate is transported from the cytosol into the mitochondrial matrix.
L-glutamate import into mitochondrion
The volume enclosed by the membrane of a magnetosome.
magnetosome lumen
The lipid bilayer surrounding a magnetosome.
magnetosome membrane
A process that contributes to the delivery of nickel ions to a target protein to facilitate its maturation.
protein maturation by nickel ion transfer
Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H+.
RNA NAD-cap (NMN-forming) hydrolase activity
Cleavage of the 5'-NAD-cap of an RNA. The NAD-cap is present at the 5'-end of some RNAs in both bacetria and eukaryotes. While it promotes RNA stability in bacteria, it promotes RNA decay in eukaryotes.
NAD-cap decapping
An extracellular complex that binds lipoprotein receptors VLDLR and APOER2, cadherin-related neuronal receptors (CNRs) or alpha3beta1 integrin and induces various downstream, reelin-dependent, phosphorylation cascades. It ultimately affects polarization, differentiation, neuronal migration and layer formation in the embryonic brain and neuron growth, maturation, and synaptic activity in the postnatal and adult brain.
reelin complex