NothingMuch/GO-Terms huggingface dataset:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an irinotecan stimulus.
response to irinotecan
Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells.
hematopoietic stem cell homeostasis
The expansion of a memory T cell population by cell division.
memory T cell proliferation
One of three laminate structures that form the mitotic spindle pole body; the inner plaque is on the nuclear face of the spindle pole body.
central plaque of mitotic spindle pole body
Structure adjacent to the plaques of the mitotic spindle pole body.
half bridge of mitotic spindle pole body
One of three laminate structures that form the mitotic spindle pole body; the inner plaque is in the nucleus.
inner plaque of mitotic spindle pole body
Structure between the central and outer plaques of the mitotic spindle pole body.
intermediate layer of mitotic spindle pole body
Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A.
tRNA threonylcarbamoyladenosine dehydratase
The chemical reactions and pathways resulting in the formation of cyclic threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules.
cyclic threonylcarbamoyladenosine biosynthetic process
Any process in which a protein is transported to, or maintained to the old mitotic spindle pole body resulting in its being distributed asymmetrically.
asymmetric protein localization to old mitotic spindle pole body
Any process in which a protein is transported to, or maintained to the new mitotic spindle pole body resulting in its being distributed asymmetrically.
asymmetric protein localization to new mitotic spindle pole body
The series of molecular signals initiated by interleukin-34 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
interleukin-34-mediated signaling pathway
The expansion of a monocyte population by cell division.
monocyte proliferation
The expansion of a microglial cell population by cell division.
microglial cell proliferation
The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
macrophage homeostasis
The process in which a precursor cell type acquires the specialized features of a Langerhans cell.
Langerhans cell differentiation
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a hepatic stellate cell.
hepatic stellate cell differentiation
Catalysis of the reaction 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H+.
1,4-dihydroxy-2-naphthoyl-CoA thioesterase activity
The process whose specific outcome is the formation of the central canal of the spinal cord from its formation to the mature structure. The central canal is a spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord.
central canal development
The regulated release of dopamine by a cell in which the dopamine acts as a neurotransmitter.
dopamine secretion, neurotransmission
The regulated release of aspartate by a cell in which the aspartate acts as a neurotransmitter.
aspartate secretion, neurotransmission
The regulated release of gamma-aminobutyric acid by a cell, in which the gamma-aminobutyric acid acts as a neurotransmitter.
gamma-aminobutyric acid secretion, neurotransmission
The controlled release of histamine by a cell, in which the histamine acts as a neurotransmitter.
histamine secretion, neurotransmission
The controlled release of octopamine by a cell, in which the octopamine acts as a neurotransmitter.
octopamine secretion, neurotransmission
The process in which the anatomical structures of a rhabdomere are generated and organized. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments.
rhabdomere morphogenesis
The regulated release of a tyramine by a cell in which the tyramine acts as a neurotransmitter.
tyramine secretion, neurotransmission
Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UMP + (1,4)-alpha-D-glucosyl(n)-glucose-1-phosphate.
glycogen synthase activity, transferring glucose-1-phosphate
The process of introducing a phosphate group into dAMP, deoxyadenosine monophosphate, to produce dADP. Addition of two phosphate groups produces dATP.
dAMP phosphorylation
The process of introducing a phosphate group into CMP, cytidine monophosphate, to produce CDP. Addition of two phosphate groups produces CTP.
CMP phosphorylation
The process of introducing a phosphate group into dCMP, deoxycytidine monophosphate, to produce dCDP. Addition of two phosphate groups produces dCTP.
dCMP phosphorylation
A protein complex involved in regulation of mRNA processing and apoptosis. It binds to RNA in a sequence-independent manner and is recruited to the EJC prior to or during the splicing process. In humans the core proteins are RNPS1, SAP18 and ACIN1.
ASAP complex
A protein complex that catalyzes the reaction acyl-CoA + sphingosine = CoA + N-acylsphingosine. In S. cerevisiae it contains three subunits: lag1, lac1 and lip1.
acyl-CoA ceramide synthase complex
The orderly movement of a corneal epithelial cell from one site to another, often during the development of a multicellular organism.
corneal epithelial cell migration
The directed movement of a colon epithelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
colon epithelial cell chemotaxis
Any process that activates or increases the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor.
positive regulation of transcription by transcription factor localization
The movement of a population of phosphatidylserine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.
calcium activated phosphatidylserine scrambling
The movement of a population of phosphatidylcholine molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.
calcium activated phosphatidylcholine scrambling
The movement of a population of galactosylceramide molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet as a result of a calcium stimulus.
calcium activated galactosylceramide scrambling
A phospholipid scrambling process that results in the appearance of phosphatidylserine on the surface of osteoblasts, and contributes to bone mineralization.
phosphatidylserine exposure on osteoblast involved in bone mineralization
Catalysis of the reaction sulfoquinovose = 6-deoxy-6-sulfofructose.
sulfoquinovose isomerase activity
Catalysis of the reaction 6-deoxy-6-sulfofructose + ATP = 6-deoxy-6-sulfofructose-1-phosphate + ADP.
6-deoxy-6-sulfofructose kinase activity
Catalysis of the reaction 6-deoxy-6-sulfofructose-1-phosphate = 3-sulfolactaldehyde + dihydroxyacetone phosphate.
6-deoxy-6-sulfofructose-1-phosphate aldolase activity
Catalysis of the reaction 2,3-dihydroxypropane-1-sulfonate + NAD+ = 3-sulfolactaldehyde + NADH + H+.
3-sulfolactaldehyde reductase activity
Catalysis of the reaction ATP + molybdopterin = diphosphate + adenylyl-molybdopterin.
molybdopterin adenylyltransferase activity
Catalysis of the reaction adenylyl-molybdopterin + molybdate = molybdenum cofactor + AMP.
molybdopterin molybdotransferase activity
Catalysis of the reaction CTP + molybdenum cofactor = diphosphate + cytidylyl molybdenum cofactor.
molybdenum cofactor cytidylyltransferase activity
Catalysis of the reaction GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.
molybdenum cofactor guanylyltransferase activity
Catalysis of the reaction: -Gly-Gly-AMP + -S-sulfanyl-L-cysteine = AMP -Gly-NH-CH(2)-C(O)SH + cysteine desulfurase.
molybdopterin-synthase sulfurtransferase activity
Catalysis of the reaction: ATP -Gly-Gly = diphosphate -Gly-Gly-AMP.
molybdopterin-synthase adenylyltransferase activity
The propionylation of the N-terminal amino acid of proteins.
N-terminal protein amino acid propionylation
Catalysis of the reaction: beta-D-fructose-1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate.
fructose-1-phosphate aldolase activity
The chemical reactions and pathways in which galactose, the aldohexose galacto-hexose, is converted to glucose-1-phosphate.
galactose to glucose-1-phosphate metabolic process
The glycolytic process in which glycerol is catabolized to pyruvate generating ATP and NADH.
glycolytic process from glycerol
The chemical reactions and pathways resulting in the breakdown of mannose into pyruvate, occurring through a fructose-6-phosphate intermediate, with the concomitant production of ATP and NADH.
glycolytic process from mannose through fructose-6-phosphate
The glycolytic process that begins with the conversion of glucose to glucose-6-phosphate by glucokinase activity. Glycolytic processes are the chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP.
canonical glycolysis
The chemical reactions and pathways resulting in the breakdown of galactose into pyruvate, with the concomitant production of a small amount of ATP.
glycolytic process from galactose
The chemical reactions and pathways resulting in the breakdown of fructose that results in the formation of dihydroxyacetone phosphate and glyceraldehyde-3-phosphate.
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
The chemical reactions and pathways resulting in the breakdown of fructose into pyruvate through a fructose-1-phosphate intermediate, with the concomitant production of ATP and NADH.
glycolytic process through fructose-1-phosphate
Binds to and increases the activity of an RNA lariat debranching enzyme.
RNA lariat debranching enzyme activator activity
The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, in which the glucose is converted to glucose-6-phosphate intermediate coupled to transmembrane transport.
transport-coupled glycolytic process through glucose-6-phosphate
Any process that affects the structure and integrity of a protein complex by altering the likelihood of its assembly or disassembly.
regulation of protein complex stability
A cytokinesis that involves a set of conserved proteins including the Cdv proteins, and results in the formation of two similarly sized and shaped cells.
Cdv-dependent cytokinesis
Any process in which a protein is transported to, or maintained at, CENP-A containing chromatin.
protein localization to CENP-A containing chromatin
Any process that activates or increases the frequency, rate or extent of glutamate secretion in response to membrane depolarization, where glutamate acts as a neurotransmitter.
positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization
The process whose specific outcome is the replacement of an existing tooth with another tooth.
tooth replacement
A protein complex located at the mitochondrial ribosome tunnel exit that is involved in efficient translation and protein complex assembly.
Cbp3p-Cbp6 complex
Repair of the gaps in the DNA helix using a discontinuous template during double-strand break repair via nonhomologous end joining.
gap filling involved in double-strand break repair via nonhomologous end joining
Binding to a member of the importin-alpha family.
importin-alpha family protein binding
The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde.
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde
The Entner-Doudoroff pathway that proceeds through a D-gluconate intermediate and yields pyruvate and D-glyceraldehyde-3-phosphate.
Entner-Doudoroff pathway through gluconate to D-glyceraldehyde-3-phosphate
Catalysis of the reaction: diphthine methyl ester + H2O = diphthine + H+ + methanol.
diphthine methylesterase activity
An specialized occluding junction where three epithelial cells meet. It is composed of a branching network of sealing strands that run perpendicularly to the bicellular tight junction at the point of contact between three epithelial cells in an epithelial sheet.
tricellular tight junction
Any process that reduces or removes the toxicity of hydrogen peroxide in a cell. These include transport of hydrogen peroxide away from sensitive areas and to compartments or complexes whose purpose is sequestration.
cellular detoxification of hydrogen peroxide
Catalysis of the reaction: ATP + methylphosphonate = alpha-D-ribose 1-methylphosphonate 5-triphosphate + adenine.
alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
A catalytic protein complex that is capable of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity.
alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex
Catalysis of the reaction: H2O + N(6)-glutaryl-L-lysyl- + NAD+ = 2''-O-glutaryl-ADP-D-ribose + L-lysyl- + nicotinamide.
protein-glutaryllysine deglutarylase activity
The removal of a glutaryl group (CO-CH2-CH2-CH2-CO) from a residue in a peptide or protein.
protein deglutarylation
A spherical, bilayered proteolipid vesicle released from gram-negative bacterial outer membranes.
bacterial outer membrane vesicle
The chemical reactions and pathways resulting in the breakdown of sucrose, to yield fructose-6-phosphate through both glucose and fructose intermediates.
sucrose catabolic process to fructose-6-phosphate through glucose and fructose
The chemical reactions and pathways resulting in the breakdown of sucrose into pyruvate through both glucose and fructose intermediates, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
glycolytic process from sucrose through glucose and fructose
The single-organism macropinocytosis process that results in the uptake of an extracellular exosome.
extracellular exosome macropinocytosis
Catalysis of 5-taurinomethyluridine in tRNA + a -S-sulfanylcysteine + ATP + a reduced electron acceptor = a 5-taurinomethyl-2-thiouridine in tRNA + a -L-cysteine + AMP + an oxidized electron acceptor + diphosphate + H+.
tRNA-5-taurinomethyluridine 2-sulfurtransferase
Catalysis of the reaction: L-threonine + ATP + bicarbonate = L-threonylcarbamoyladenylate + diphosphate + H2O.
L-threonylcarbamoyladenylate synthase
Catalysis of the reaction: L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA.
N(6)-L-threonylcarbamoyladenine synthase activity
Catalysis of the reaction: N(6)-L-threonylcarbamoyladenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N(6)-L-threonylcarbamoyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine.
tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase
The step in the formation of the neural tube, where the paired anterior neural folds are brought together and fuse at the dorsal midline.
anterior neural tube closure
The directed movement of a processed miRNA from the nucleus to the cytoplasm.
miRNA export from nucleus
The chemical reactions and pathways resulting in the breakdown of glucose into pyruvate, with the concomitant production of a small amount of ATP and the utilization of ADP in the initial kinase reactions.
glucose catabolic process to pyruvate utilizing ADP
The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and 3-sulfolactaldehyde (SLA).
6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde
The chemical reactions and pathways resulting in the breakdown of 6-sulfoquinovose(1-) resulting in the formation of glycerone phosphate (DHAP) and 3-sulfopropanediol(1-).
6-sulfoquinovose(1-) catabolic process to 3-sulfopropanediol(1-)
The selective degradation of glycogen by macroautophagy.
glycophagy
The chemical reactions and pathways resulting in the breakdown of lipid droplets and hydrolysis of stored triglycerides occurring through the orchestrated activation of cytosolic lipases.
cytosolic lipolysis
The chemical reactions and pathways resulting in the formation of GDP-mannose from mannose.
GDP-mannose biosynthetic process from mannose
The chemical reactions and pathways resulting in the formation of GDP-mannose from fructose-6-phosphate.
GDP-mannose biosynthetic process from fructose-6-phosphate
Binding to C-rich, single-stranded, telomere-associated DNA.
C-rich strand telomeric DNA binding
The membrane invagination process by which an autophagosomal membrane surrounds an object that will be degraded by macroautophagy.
engulfment of target by autophagosome
A G protein-coupled receptor signaling pathway initiated by leukotriene binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
leukotriene signaling pathway
The autophagy process by which cytosolic proteins targeted for degradation are tagged with a chaperone and are directly transferred into and degraded in a late endosomal compartment.
late endosomal microautophagy
The protein lipidation process by which phosphatidylethanolamine is conjugated to a protein of the ATG8 family, leading to membrane insertion of the protein as a step in autophagosome assembly.
protein lipidation involved in autophagosome assembly
The targeting of a protein to the lysosome process in which an input protein binds to a chaperone and subsequently to a lysosomal receptor.
protein targeting to lysosome involved in chaperone-mediated autophagy
Any process in which an organism acquires a novel neuromuscular action or movement as the result of experience.
motor learning
Unwinding a DNA helix containing forked DNA, driven by ATP hydrolysis.
forked DNA-dependent helicase activity
Any process that increases the quantity of fibrinogen circulating in the bloodstream.
positive regulation of circulating fibrinogen levels
The directed movement of substances from late endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome.
late endosome to lysosome transport via multivesicular body sorting pathway
Catalysis of the reaction: Na+(in) + Mg2+(out) = Na+(out) + Mg2+(in).
magnesium:sodium antiporter activity
Catalysis of the reaction: N-ribosylnicotinate + ATP = ADP + 2 H+ + nicotinate mononucleotide.
ribosylnicotinate kinase activity
Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation.
translation elongation factor binding
Subunit of the MHC class I peptide loading complex (GO:0042824) (=PLC) involved in the assembly of the heavy-chain-beta2-microglobulin dimers of the MHC class I molecules that fold with eight to ten residue peptides in the endoplasmic reticulum. Required for the inhibition of the reduction of the disulfide bonds of the heavy chains and the assembly and stabilization of the PLC, suggesting it may play a structural rather than a catalytic role.
Tapasin-ERp57 complex
Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) from peptidoglycan.
peptidoglycan N-acetylglucosaminidase activity
A peptidoglycan endopeptidase activity that acts on a stem peptide of peptidoglycan.
peptidoglycan stem peptide endopeptidase activity
The initial attachment of a dense core granule membrane to the plasma membrane.
dense core granule docking
A mitotic cell cycle process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion.
membrane addition at site of mitotic cytokinesis
A gated channel activity that enables the transmembrane transfer of a chloride ion by a channel that opens in response to a change in pH.
pH-gated chloride channel activity
Catalysis of the reaction: GTP=(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
GTP 3',8'-cyclase activity
Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate.
cyclic pyranopterin monophosphate synthase activity
A supramolecular fiber formed from fibronectin molecules. The fibrils are 5 to 25nm in diameter and can form branched meshworks.
fibronectin fibril
The region that lies just beneath the plasma membrane in the part of a cell that is closest to the anterior as defined by the developing, or existing, anterior/posterior axis.
anterior cell cortex
The region that lies just beneath the plasma membrane in the part of a cell that is closest to the posterior as defined by the developing, or existing, anterior/posterior axis.
posterior cell cortex
The selective degradation of proteasomes by macroautophagy.
proteaphagy
The process of assisting in the folding of tRNAs into the correct tertiary structure.
tRNA folding
A ring-like structure observed at the base of the ciliary cap of insect spermatids. This structure may anchor the axoneme to the ciliary cap membrane and/or act as a diffusion barrier, proposed to be analogous to the annulus of mammalian sperm flagellum.
ring centriole
The F-actin-rich core of an adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell.
podosome core
The ring structure surrounding the podosome core, containing proteins such as vinculin and talin.
podosome ring
The concave part of the late spermatid head or spermatozoon head that forms the ventral portion of the head, particularly in some rodent species.
concave side of sperm head
A process in which a protein is transported to, or maintained in, a location within a tricellular tight junction.
protein localization to tricellular tight junction
The surface of a migrating cell that is in contact with the substratum or cell layer.
ventral surface of cell
Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a neuropeptide precursor. Processing leads to the attainment of the full functional capacity of the neuropeptide.
neuropeptide processing
A histone-variant containing protein complex which forms a centromere specific nucleosome-like structure, involved in centromeric chromatin organization.
CENP-T-W-S-X complex
The region of the neuronal cytoplasm located in dendritic spines.
dendritic spine cytoplasm
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholecystokinin stimulus.
cellular response to cholecystokinin
Binding to telomeric G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures in telomeres.
telomeric G-quadruplex DNA binding
That part of the lamellipodium which represents the distal part of the structure.
leading edge of lamellipodium
Any process that activates or increases the frequency, rate or extent of neuroblast migration.
positive regulation of neuroblast migration
Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration.
negative regulation of neuroblast migration
Catalysis of the transfer of tubulin dimers to the plus end of a microtubule. The reaction is reversible depending on the availability of dimers.
microtubule plus end polymerase