NothingMuch/GO-Terms huggingface dataset:
The process in which a manganese ion is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial manganese ion transmembrane transport
The process in which S-adenosyl-L-methionine is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial S-adenosyl-L-methionine transmembrane transport
The process in which ATP is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial ATP transmembrane transport
The process in which thiamine pyrophosphate is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial thiamine pyrophosphate transmembrane transport
The process in which a phosphate ion is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial phosphate ion transmembrane transport
The process in which FAD is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial FAD transmembrane transport
The process in which NAD is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial NAD transmembrane transport
The process in which 2-oxoadipate is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial 2-oxoadipate transmembrane transport
The process in which 5'-adenylyl sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial 5'-adenylyl sulfate transmembrane transport
The process in which 3'-phospho-5'-adenylyl sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial 3'-phospho-5'-adenylyl sulfate transmembrane transport
The process in which oxaloacetate is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial oxaloacetate transmembrane transport
The process in which 2-isopropylmalate(2-) is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial isopropylmalate transmembrane transport
The process in which sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial sulfate transmembrane transport
The process in which malonate(1-) is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial malonate(1-) transmembrane transport
The process in which coenzyme A is transported across a mitochondrial membrane, into or out of the mitochondrion.
mitochondrial coenzyme A transmembrane transport
A protein kinase chaperone complex required for the proper folding, maturation and stabilization of target proteins (mostly signaling protein kinases, some steroid hormone receptors), usually during or immediately after completion of translation. The highly conserved, phosphorylated CDC37-Ser13 (vertebrates) or cdc37-Ser14 (yeast) is essential for complex assembly and target protein binding. CDC37-Ser13 (Ser14) is phosphorylated by Casein kinase II (CK2), which in turn is a target of CDC37 creating a positive feedback loop. Complex binding also prevents rapid ubiquitin-dependent proteosomal degradation of target proteins.
HSP90-CDC37 chaperone complex
A protein serine/threonine phosphatase complex that in S. pombe consists of the proteins Dis2, Ppn1, and Swd22.
DPS complex
Any of the meiotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell.
meiotic spindle astral microtubule
The removal of a methyl group from the C-terminal amino acid of a protein.
C-terminal protein demethylation
Any process that modulates the frequency, rate or extent of cytoplasmic translational termination.
regulation of cytoplasmic translational termination
Binds to and increases the activity of the enzyme phospholipase D.
phospholipase D activator activity
Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway.
ATF4-CREB1 transcription factor complex
Transcription factor complex consisting of ATF1 and ATF4 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT-3') of the GRP78 (HSPA5) promoter. Involved in the ER stress response pathway.
ATF1-ATF4 transcription factor complex
The directed movement of asparagine into the vacuole across the vacuolar membrane.
asparagine transmembrane import into vacuole
A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein.
protein K69-linked ufmylation
Combining with basic secretagogues to initiate pseudo-allergic reactions in mast cells.
mast cell secretagogue receptor activity
Catalysis of the hydrolysis of ester linkages within 3' overhang single-stranded deoxyribonucleic acid by creating internal breaks.
3' overhang single-stranded DNA endodeoxyribonuclease activity
Increases the activity of a single-stranded DNA endodeoxyribonuclease activator activity.
single-stranded DNA endodeoxyribonuclease activator activity
Catalysis of the hydrolysis of ester linkages within 5' overhang single-stranded deoxyribonucleic acid by creating internal breaks.
5' overhang single-stranded DNA endodeoxyribonuclease activity
The process by which the rods of the retina gradually become fully responsive to dim light when no longer exposed to bright light.
dark adaptation
Binding to an RNA molecule containing GU repeats.
GU repeat RNA binding
Generation of a 'twisting' activity resulting in the scission of a membrane, driven by GTP hydrolysis.
membrane scission GTPase motor activity
Binds to and modulates the activity of glutamate-cysteine ligase.
glutamate-cysteine ligase regulator activity
Binds to and modulates the activity of acetolactate synthase.
acetolactate synthase regulator activity
A LINC complex implicated in the connection of DNA double strand breaks to the cytoskeleton during DNA double-strand break repair.
Sad1-Kms1 LINC complex
Binds to and stops, prevents or reduces the activity of a guanyl nucleotide exchange factor.
guanyl nucleotide exchange factor inhibitor activity
Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress.
negative regulation of cytoplasmic translational initiation in response to stress
A type of punctate focus localized to the perinuclear region of germline cytoplasm in C. elegans. Mutator foci are required for RNA interference (RNAi) and serve as sites of small inhibitory RNA (siRNA) amplification. As such, proteins that localize to mutator foci include RNA-directed RNA polymerases (RdRPs) and beta-nucleotidyltransferases. Mutator foci are distinct from, but adjacent to or partially overlap, P granules.
mutator focus
Catalysis of the reaction: 1D-myo-inositol 2,4,5-trisphosphate + H2O = 1D-myo-inositol 2,4-bisphosphate + phosphate.
inositol-2,4,5-triphosphate 5-phosphatase activity
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion.
response to iron ion starvation
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus.
cellular response to granulocyte colony-stimulating factor
The binding activity of a molecule that attaches the spindle microtubules to the kinetochore.
microtubule site clamp
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus.
cellular response to prolactin
Catalysis of the reaction: 1D-myo-inositol 4,5,6-trisphosphate + H2O = 1D-myo-inositol 4,6-bisphosphate + phosphate.
inositol-4,5,6-triphosphate 5-phosphatase activity
Catalysis of the reaction: 1D-myo-inositol 1,2,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,4-trisphosphate + phosphate.
inositol-1,2,4,5-tetrakisphosphate 5-phosphatase activity
Catalysis of the reaction: 1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,6-trisphosphate + phosphate.
inositol-2,4,5,6-tetrakisphosphate 5-phosphatase activity
Catalysis of the reaction: 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,4,6-tetrakisphosphate + phosphate.
inositol-1,2,4,5,6-pentakisphosphate 5-phosphatase activity
A protein complex capable of stimulus-inducible nitric-oxide synthase activity. S-nitrosylates cysteine residues in target proteins, a principal mechanism of nitric oxide (NO)-mediated signal transduction. In mammals consists of NOS2, S100A8 and S100A9. S100A9 acts both as an adaptor linking NOS2 to its target and as a transnitrosylase that transfers the nitric oxide moiety from NOS2 to its target, via its own S-nitrosylated cysteine.
iNOS-S100A8/A9 complex
Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate.
dihydroorotate dehydrogenase (fumarate) activity
The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi medial cisterna. This can involve anterograde or retrograde transport vesicles.
vesicle fusion with Golgi medial cisterna membrane
The joining of the lipid bilayer membrane around a medial-Golgi-derived vesicle to the lipid bilayer membrane around the Golgi trans cisterna. Vesicles are involved in anterograde transport.
medial-Golgi-derived vesicle fusion with Golgi trans cisterna membrane
A process in which the DNA double-strand breaks are attached to the inner surface of the nuclear envelope proximal to the spindle pole body, or iMTOCs.
DNA double-strand break attachment to nuclear envelope
A protein-lipid-RNA complex containing separate high-density lipoprotein (HDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other.
HDL-containing protein-lipid-RNA complex
A protein-lipid-RNA complex containing separate low-density lipoprotein (LDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other.
LDL-containing protein-lipid-RNA complex
The removal of palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), from a lipoprotein.
protein depalmitoleylation
Catalysis of the transfer of a palmitoleoyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule.
palmitoleoyltransferase activity
Catalysis of a hydrolase reaction that removes a palmitoleyl moiety, a 16-carbon monounsaturated fatty acid (C16:1), from some substrate.
palmitoleyl hydrolase activity
The associative learning process by which an animal learns and remembers an association between a neutral, unchanging environment and a putatively rewarding, internal state produced by a xenobiotic or drug.
conditioned place preference
A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.
HFE-transferrin receptor complex
Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the two bridges which connect the central pair of single microtubules.
axonemal central bridge
Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the projections off of the central pair of single microtubules.
axonemal central pair projection
A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway.
Lsm1-7-Pat1 complex
A multimeric protein complex involved in tubulin alpha-beta-subunit folding assembly consisting of beta-tubulin-TFC-D, alpha-tubulin-TFC-E and TFC-C, through which tubulin subunit association and dimer release occur.
tubulin folding cofactor complex
A non-membrane-bounded organelle found within the chloroplasts of algae and hornworts; responsible for carbon dioxide fixation.
pyrenoid
Any process in which an astral microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end.
astral microtubule anchoring at mitotic spindle pole body
Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate.
pseudouridine 5'-phosphatase activity
A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein.
protein sialylation
A quatrefoil tethering complex required for endocytic recycling.
EARP complex
Increases the activity of the enzyme polynucleotide adenylyltransferase.
polynucleotide adenylyltransferase activator activity
The region of the cell cortex in a mitotically dividing cell that flanks the central spindle and corresponds to the site of actomyosin ring formation that results in cleavage furrow formation and ingression.
equatorial cell cortex
A thin sheetlike process extended by the leading edge of an axonal or dendritic growth cone; contains a dense meshwork of actin filaments.
growth cone lamellipodium
The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase involved in cytoplasmic translation.
cytoplasmic alanyl-tRNA aminoacylation
Binding to a member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors.
arrestin family protein binding
The process that results in the uptake of a prostaglandin receptor into an endocytic vesicle.
prostaglandin receptor internalization
The portion of an axon or dendrite that is close to the neuronal cell body.
proximal neuron projection
The leaflet of the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface surrounding a dendritic spine.
cytoplasmic side of dendritic spine plasma membrane
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus given while being held immobile.
response to immobilization stress combined with electrical stimulus
Cytoplasm situated near, or occurring around, a phagosome.
periphagosomal region of cytoplasm
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus.
cellular response to dsDNA
A protein repressing GLI's transcription factor activity when SMO signaling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins.
GLI-SUFU complex
The region of a cell situated by the cell sides which interface adjacent cells and near the base. Often used in reference to animal polarized epithelial cells.
basolateral part of cell
A specialized region of the axon terminus portion of a rod bipolar axon. A rod bipolar cell is a neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer.
rod bipolar cell terminal bouton
A specialized region of the axon terminus portion of a photoreceptor cell axon. A photoreceptor cell is a neuron specialized to detect and transduce light.
photoreceptor cell terminal bouton
The regrowth of a destroyed pancreas.
pancreas regeneration
The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.
mitochondrial tRNA wobble position uridine thiolation
A scaffolding structure present within the inner region of the ciliary transition zone. The central cylinder lies between the outer doublet and inner singlet microtubules.
central cylinder
Binding to an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins.
F-bar domain binding
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network membrane.
endoplasmic reticulum tubular network membrane organization
Any process in which a microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end.
microtubule anchoring at mitotic spindle pole body
A thin, stiff protrusion extended by the leading edge of an axonal or dendritic growth cone.
growth cone filopodium
Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif.
sequence-specific mRNA binding
Binding to an enzyme that catalyzes the removal of an amino group from a substrate, producing ammonia (NH3).
deaminase binding
The process in which a hepatocyte (specialized epithelial cell of the liver) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.
hepatocyte dedifferentiation
The directed slow movement of non-membranous molecules in nerve cell axons. It is comprised of a Slow Component a (SCa) and a Slow Component b (SCb) which differ in transport rates and protein composition.
slow axonal transport
Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the removal of clathrin from vesicle membranes, coupled to the hydrolysis of ATP.
clathrin-uncoating ATPase activity
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell.
response to odorant
A matrix composed of supramolecular assemblies of lysosomal enzymes and lipids which forms at a pH of 5.0 within the lysosome.
lysosomal matrix
Catalysis of 3' exonucleolytic cleavage of poly(U), to form poly(U)-N containing a 3' uridine cyclic phosphate (U>P).
poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends
Binding to a section of chromatin that is associated with gene promoter sequences of DNA.
promoter-specific chromatin binding
Binds to and stops, prevents or reduces the activity of ribonucleoside-diphosphate reductase.
ribonucleoside-diphosphate reductase inhibitor activity
Binding to methionine-initiator methionine tRNA.
methionyl-initiator methionine tRNA binding
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3).
cellular response to endothelin
A cyclin dependent kinase (CDK) complex that contains a kinase subunit and a regulatory cyclin subunit. An example of this complex in budding yeast S. cerevisiae consists of the Pho85 kinase and the Pho80 cyclin.
Pho85-Pho80 CDK-cyclin complex
A protein complex that resides in the inner nuclear membrane and anchors telomeres to the nuclear envelope. In fission yeast, it is composed of Bqt3 and Bqt4.
nuclear membrane complex Bqt3-Bqt4
A protein complex that is involved in the assembly of the V-ATPase complex. In the budding yeast Saccharomyces cerevisiae, this complex consists of Vma12p and Vma22p.
Vma12-Vma22 assembly complex
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus.
cellular response to gastrin
Any process that reduces or removes the toxicity of copper ions in a cell. These include transport of copper cations away from sensitive areas and to compartments or complexes whose purpose is sequestration.
cellular detoxification of copper ion
Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA.
rRNA cytidine N-acetyltransferase activity
Catalysis of the reaction: 2-polyprenyl-6-hydroxyphenol + S-adenosyl-L-methionine = 2-polyprenyl-6-methoxyphenol + S-adenosyl-L-homocysteine + H+.
2-polyprenyl-6-hydroxyphenol O-methyltransferase activity
Binding to a histone H4 in which the lysine residue at position 20 has been modified by trimethylation.
H4K20me3 modified histone binding
Binding to a netrin receptor.
netrin receptor binding
The cell cycle process in which chromosome arm chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
mitotic chromosome arm condensation
The cell pole distal from the most recent cell division.
old cell pole
The cell pole proximal to the most recent cell division.
new cell pole
A small, flexible, finger-like projection of cytoplasm containing an array of microtubles and located near the flagellar pores in some photosynthetic as well as nonphotosynthetic dinoflagellate species. Its functions are not fully understood, but it has been associated with feeding behavior (phagotrophy).
dinoflagellate peduncle
A cilium-like cell projection emanating from the inner segment and running alongside the outer segment of photoreceptors.
accessory outer segment
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension combined with low atmospheric pressure. Hypoxia is defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95% and hypobaric is defined as atmospheric pressure below 0.74 atm (greater than 2,500 m above sea level).
response to hypobaric hypoxia
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism.
response to psychosocial stress
The plasma membrane that is part of the head section of a sperm cell.
sperm head plasma membrane
The action of a molecule that contributes to the structural integrity of an ascospore wall.
structural constituent of ascospore wall
The outermost layers of the spore wall, as described in Schizosaccharomyces pombe.
Isp3 layer of spore wall
The cytoplasm of an ovum.
ooplasm
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination.
double-strand break repair involved in meiotic recombination
The process of secretion by a cell that results in the release of intracellular molecules contained within a lysosome by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels.
calcium ion regulated lysosome exocytosis
Catalyzes the hydrolysis of terminal non-reducing alpha-sulfoquinovoside residues in alpha-sulfoquinovosyl diacylglycerides and alpha-sulfoquinovosyl glycerol, generating alpha-sulfoquinovose.
sulfoquinovosidase activity
Binding to 5.8S ribosomal RNA, a eukaryotic ribosomal RNA which forms a complex with 28S RNA.
5.8S rRNA binding