NothingMuch/GO-Terms huggingface dataset:
A wide pore channel activity that enables a direct cytoplasmic connection from a bundle of His cell to a Purkinje myocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction.
gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling
A wide pore channel activity that enables a direct cytoplasmic connection from a Purkinje myocyte to a ventricular cardiac muscle cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction.
gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling
Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells.
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
Binding to a protein or protein complex that results in the connection of a Purkinje myocyte with an ventricular cardiac muscle cell and contributes to the communication between the two cells.
cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization
A cardiac conduction process that modulates the frequency or rate of heart contraction.
regulation of heart rate by cardiac conduction
A cardiac conduction process that modulates the extent of heart contraction, changing the force with which blood is propelled.
regulation of the force of heart contraction by cardiac conduction
Catalysis of the reaction: di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose = alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP.
undecaprenyl-phosphate glucose phosphotransferase activity
The directed movement of L-aspartate out of the vacuole, across the vacuolar membrane.
L-aspartate transmembrane export from vacuole
The directed movement of L-glutamate out of the vacuole, across the vacuolar membrane.
L-glutamate transmembrane export from vacuole
A process in which a protein is transported to, or maintained in, a specific location the cell outer membrane.
protein localization to outer membrane
The directed movement of L-ornithine out of the vacuole, across the vacuolar membrane.
L-ornithine transmembrane export from vacuole
The directed movement of L-histidine out of the vacuole, across the vacuolar membrane.
L-histidine transmembrane export from vacuole
Binding to a endocytic signal sequence, a specific peptide sequence, of 4-6 amino acids with an essential tyrosine (Y), found on cytoplasmic tails of some cell surface membrane proteins, which directs internalization by clathrin-coated pits.
endocytic targeting sequence binding
A heteromeric complex consisting of Cbf1 and basic leucine zipper (bZIP) containing transcriptional activators, Met4 and Met28, that forms over the sequence TCACGTG in the upstream activating sequence (UAS) of genes involved in sulfur amino acid metabolism, resulting in their transcriptional activation.
Cbf1-Met4-Met28 complex
Catalysis of the reaction: UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+.
UDP-N-acetyl-D-mannosamine dehydrogenase activity
A heterodimeric complex consisting of Zn(2)Cys(6) containing transcription factors Pip2 and Oaf1. It binds to the oleate response element (ORE), found in the promoters of fatty acid-inducible genes in Saccharomyces where, in the presence of oleate this bound complex activates the transcription of genes encoding peroxisomal proteins.
Pip2-Oaf1 complex
Binding to a caspase family protein.
caspase binding
A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic tRNA transcription unit.
replication fork arrest at tRNA locus
The process whose specific outcome is the progression of the hypoblast over time, from its formation to the mature structure. The hypoblast is a tissue formed from the inner cell mass that lies beneath the epiblast.
hypoblast development
The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis.
primitive streak formation
The formation of anterior end of the flat, thickened layer of ectodermal cells known as the neural plate.
anterior neural plate formation
Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
positive regulation of neutrophil chemotaxis
Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
negative regulation of neutrophil chemotaxis
Any process that increases the frequency, rate, or extent of monocyte chemotaxis.
positive regulation of monocyte chemotaxis
Any process that decreases the frequency, rate, or extent of monocyte chemotaxis.
negative regulation of monocyte chemotaxis
Any process that increases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion.
positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
Any process that decreases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion.
negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
Any process that increases the frequency, rate, or extent of chaperone-mediated protein complex assembly. Chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex.
positive regulation of chaperone-mediated protein complex assembly
Any process that increases the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid.
positive regulation of tubulin deacetylation
Any process that activates or increases the frequency, rate or extent of deacetylase activity, the catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.
positive regulation of deacetylase activity
Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.
positive regulation of cell migration involved in sprouting angiogenesis
Any process that decreases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.
negative regulation of cell migration involved in sprouting angiogenesis
The radial pattern formation process that results in the formation of the different tissues of the root around its radial axis.
root radial pattern formation
The process whose specific outcome is the progression of the protoxylem over time, from its formation to the mature structure. The protoxylem comprises the first formed elements of the primary xylem.
protoxylem development
Any process that modulates the frequency, rate, or extent of metaxylem development. Metaxylem development is the process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed.
regulation of metaxylem development
Any process that starts the inactive process of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.
activation of microtubule nucleation
Any process that modulates the size of the thalamus. The thalamus is a part of the diencephalon that is composed of the dorsal thalamus and the ventral thalamus.
regulation of thalamus size
Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.
positive regulation of ribosome biogenesis
Any process that decreases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.
negative regulation of protein homodimerization activity
A process in which the extent of skeletal muscle tissue contraction is reduced. Muscle relaxation involves the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases.
relaxation of skeletal muscle
The process in which a smooth muscle cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
smooth muscle derived foam cell differentiation
Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.
positive regulation of extracellular matrix disassembly
Any process that increases the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip.
positive regulation of metanephric cap mesenchymal cell proliferation
The process in which the cochlea is generated and organized.
cochlea morphogenesis
The process whose specific outcome is the progression of a pancreatic E cell over time, from its formation to the mature structure.
pancreatic E cell development
The commitment of a cell to a pancreatic E cell fate and its capacity to differentiate into a pancreatic E cell.
pancreatic E cell fate commitment
Any process that increases the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle.
positive regulation of high-density lipoprotein particle assembly
Any process that modulates the frequency, rate or extent of COPII vesicle uncoating, the process in which COPII vesicle coat proteins are disassembled, and released.
regulation of COPII vesicle uncoating
The disassembly into constituent parts of the low-density lipoprotein particle in the lysosome that contributes to cholesterol transport.
low-density lipoprotein particle disassembly involved in cholesterol transport
The cholesterol metabolic process in which cholesterol esters are hydrolyzed into free fatty acids and cholesterol in the lysosome that contributes to intracellular cholesterol transport.
cholesterol ester hydrolysis involved in cholesterol transport
The polysaccharide-based coating on the inner side of a lysosomal membrane. It may be involved in protecting the membrane from digestion by lysosomal enzymes.
lysosomal glycocalyx
Any process that increases the extent of synaptic maturation as a result of the communication from a pre-synaptic cell to a post-synaptic cell across a synapse.
positive regulation of synapse maturation by synaptic transmission
The formation of daughter actin filament branches at an angle on the sides of preexisting mother filaments.
actin filament branching
The directed movement of substances from the Golgi to lysosomes.
Golgi to lysosome transport
The specification and formation of the polarity of an epithelial cell along the plane of the epithelial tissue.
establishment of epithelial cell planar polarity
The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that modulates the controlled release of a substance from a polarized epithelial cell.
regulation of secretion by asymmetric Golgi ribbon formation
Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division.
regulation of Golgi inheritance
Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube.
regulation of establishment of planar polarity involved in neural tube closure
Any process that increases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine.
positive regulation of pancreatic juice secretion
Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine.
negative regulation of pancreatic juice secretion
Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
positive regulation of branching involved in ureteric bud morphogenesis
Any process that decreases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.
negative regulation of branching involved in ureteric bud morphogenesis
Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
positive regulation of release of cytochrome c from mitochondria
Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
negative regulation of release of cytochrome c from mitochondria
Any process that decreases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid.
negative regulation of lipid kinase activity
The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from within the mitotic spindle.
mitotic spindle-templated microtubule nucleation
The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from the centrosome.
centrosome-templated microtubule nucleation
The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from chromatin.
chromatin-templated microtubule nucleation
The attachment of one cell to another cell via adhesion molecules that contributes to the establishment of planar cell polarity.
cell-cell adhesion involved in establishment of planar polarity
The process in which the population of cells that make up a wing epithelium undergo directed movement and contribute to imaginal disc-derived morphogenesis.
epithelium migration involved in imaginal disc-derived wing morphogenesis
The morphogenetic process in which the wing epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to imaginal disc-derived wing morphogenesis.
convergent extension involved in imaginal disc-derived wing morphogenesis
The process in which a cell elongates and contributes to imaginal disc-derived wing morphogenesis.
cell elongation involved in imaginal disc-derived wing morphogenesis
Any process that modulates the frequency, rate, or extent of the multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis.
regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis
Any process that modulates the frequency, rate, or extent of the nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway.
regulation of transcription-coupled nucleotide-excision repair
Any process that increases the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages.
positive regulation of immune complex clearance by monocytes and macrophages
Any process that starts the inactive process of a mitotic cell cycle spindle assembly checkpoint.
activation of mitotic cell cycle spindle assembly checkpoint
Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
positive regulation of fibroblast growth factor production
Any process that decreases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
negative regulation of fibroblast growth factor production
Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.
positive regulation of somatostatin secretion
Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.
negative regulation of somatostatin secretion
Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.
positive regulation of osteoclast proliferation
Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.
negative regulation of osteoclast proliferation
Any process that increases the rate, frequency or extent of chylomicron remnant clearance. Chylomicron clearance is the process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded.
positive regulation of chylomicron remnant clearance
Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.
positive regulation of locomotion involved in locomotory behavior
Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.
negative regulation of locomotion involved in locomotory behavior
Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.
regulation of olfactory learning
Any process that modulates the rate, frequency, or extent of stomatal closure. Stomatal closure is the process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange.
regulation of stomatal closure
Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
positive regulation of brown fat cell differentiation
Any process that increases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.
positive regulation of formin-nucleated actin cable assembly
Any process that decreases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.
negative regulation of formin-nucleated actin cable assembly
Any process that increases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell.
positive regulation of secretion of lysosomal enzymes