NothingMuch/GO-Terms huggingface dataset:
The process whose specific outcome is the progression of the posterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter.
posterior lateral line neuromast cupula development
The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing posterior lateral line.
posterior lateral line neuromast deposition
The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast mantle cell. (N.B. This may be development of neuromast mantle cell type or a set of cells of neuromast mantle cell type. This will involve the change of a cell or set of cells from one cell identity to another). Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded.
posterior lateral line neuromast mantle cell differentiation
The process whose specific outcome is the progression of the electrosensory lateral line system over time, from its formation to the mature structure.
electrosensory lateral line system development
The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells.
posterior lateral line neuromast support cell differentiation
The process in which a relatively unspecialized cell acquires specialized features of a neuron of the posterior lateral line ganglion.
posterior lateral line ganglion neuron differentiation
The process whose specific outcome is the progression of an efferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the posterior lateral line nerve.
efferent axon development in posterior lateral line nerve
The movement of a glial cell along the axons in the posterior lateral line nerve.
glial cell migration in posterior lateral line nerve
The formation of compact myelin sheaths around the axons of the posterior lateral line nerve.
myelination of posterior lateral line nerve axons
The process whose specific outcome is the progression of an afferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the posterior lateral line nerve.
afferent axon development in posterior lateral line nerve
Generation of a long process from a neuron whose cell body resides in the peripheral nervous system. The axon carries action potential from the cell body towards target cells.
peripheral nervous system neuron axonogenesis
Catalysis of the reaction: L-arabinitol + NAD+ = L-xylulose + H+ + NADH.
L-arabinitol 4-dehydrogenase activity
Catalysis of the reaction: L-ornithine = D-ornithine.
ornithine racemase activity
Catalysis of the reaction: NAD+ + propane-1,2-diol 1-phosphate = H+ + hydroxyacetone phosphate + NADH.
propanediol-phosphate dehydrogenase activity
Catalysis of the reaction: S-succinylglutathione + H2O = glutathione + H+ + succinate.
S-succinylglutathione hydrolase activity
Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor.
uracil dehydrogenase activity
Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+.
calcium-dependent phospholipase C activity
Binding to a microfibril, any small fibril occurring in biological material.
microfibril binding
Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid.
acyloxyacyl hydrolase activity
Catalysis of the reaction: 7-deoxyloganin + O2 + reduced  = H+ + H2O + loganin + oxidized .
7-deoxyloganin 7-hydroxylase activity
Binding to an AF-2 protein domain, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation.
AF-2 domain binding
Binding to an AF-1 protein domain, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor.
AF-1 domain binding
Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.
WW domain binding
Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family.
CARD domain binding
Binding to an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing.
RS domain binding
The modification of peptidyl-selenocysteine.
peptidyl-selenocysteine modification
The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system that can be controlled at will.
voluntary musculoskeletal movement
Involuntary movement caused by the application of a stimulus to an organism and a subsequent movement. The signal processing of this movement takes place in the spinal cord.
musculoskeletal movement, spinal reflex action
The determination of the type or quality of a sensation. Sensory modalities include touch, thermal sensation, visual sensation, auditory sensation and pain.
determination of sensory modality
The determination of where on the body surface, within the body or in the environment a stimulus originates.
determination of stimulus location
The determination of the perceived strength of a sensory stimulus.
determination of stimulus intensity
Any process in which an emotional response is associated with a particular sensory stimulation.
determination of affect
The formation of an integrin-dependent strong adhesive bond between leukocytes and blood vessel endothelial cells which is dependent on prior activation of the leukocyte and leads to the firm attachment of the leukocyte to the endothelial surface, typically the third step in cellular extravasation.
leukocyte activation-dependent arrest
Any process that initiates the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical.
induction of negative chemotaxis
Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.
induction of positive chemotaxis
The carboxylation of the N-terminal amino acid of proteins.
N-terminal protein amino acid carboxylation
Binding to Hsp27 proteins, a lightweight heat shock protein.
Hsp27 protein binding
Binding to the plus end of a microtubule.
microtubule plus-end binding
Binding to the minus end of a microtubule.
microtubule minus-end binding
The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids.
chiasma assembly
Enables the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other.
tRNA transmembrane transporter activity
Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other.
DNA transmembrane transporter activity
Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
NF-kappaB binding
The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs constantly, regardless of environmental conditions or demands.
constitutive protein ectodomain proteolysis
The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine) or peptidyl-3'-(phospho-5'-adenosine)-L-histidine (otherwise known as pi-AMP-histidine, pros-AMP-histidine).
peptidyl-histidine adenylylation
The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine) or peptidyl-3'-(phospho-5'-uridine)-L-histidine (otherwise known as pi-UMP-histidine, pros-UMP-histidine).
peptidyl-histidine uridylylation
Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
ATPase binding
Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3.
hepoxilin A3 synthase activity
Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic.
alpha-keto amide reductase activity
Catalysis of the reaction: alpha-ketoester + H+ + NADPH = (R)-hydroxy ester + NADP+.
alpha-ketoester reductase (NADPH) activity
Binding to histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.
histamine binding
The modification of tRNA structure by addition of an acetyl group to tRNA. An acetyl group is CH3CO-, derived from acetic  acid.
tRNA acetylation
Binding to a BH1 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists.
BH1 domain binding
Binding to a BH2 protein domain, present in Bcl-2 family members. Proteins that act as inhibitors of apoptosis harbour at least three BH domains: BH1, BH2 and BH3; the BH1 and BH2 domains are found in all death antagonists of the Bcl-2 family but only in one class of death agonists.
BH2 domain binding
Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death.
BH3 domain binding
Binding to a BH4 protein domain, present in Bcl-2 family members. All anti-apoptotic proteins contain BH1 and BH2 domains; some also contain an additional N-terminal BH4 domain, which is almost never seen in pro-apoptotic proteins. Loss of the BH4 domain can diminish or abrogate anti-apoptotic function or even impart outright death-promoting properties to the protein.
BH4 domain binding
The series of events by which a glucocorticoid hormone stimulus is received by a cell and converted into a molecular signal. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
detection of glucocorticoid hormone stimulus
Enables the transfer of a glucosylglycerol from one side of a membrane to the other. A glucosylglycerol is an alpha-D-glucopyranosyl-alpha-(1,2)-glycerol.
glucosylglycerol transmembrane transporter activity
Enables the transfer of a mannosylglycerate from one side of a membrane to the other.
mannosylglycerate transmembrane transporter activity
Catalysis of the reaction: D-tyrosyl-tRNATyr + H2O = D-tyrosine + tRNATyr. Removal of a D-tyrosine from a charged tRNA(Tyr).
D-tyrosyl-tRNA(Tyr) deacylase activity
Any process that initiates the inactive process of bipolar cell growth, polarized growth from both ends of a cell.
activation of bipolar cell growth
Any process that stops the active process of bipolar cell growth, polarized growth from both ends of a cell.
termination of bipolar cell growth
Any process that stops the active process of bipolar cell growth, polarized growth from one end of a cell.
termination of monopolar cell growth
Any process that initiates the inactive process of monopolar cell growth, polarized growth from one end of a cell.
activation of monopolar cell growth
The process in which a cell switches from bipolar cell growth to monopolar cell growth.
cell growth mode switching, bipolar to monopolar
The chemical reactions and pathways resulting in the formation of leucoanthocyanidins, a class of colorless intermediates in the biosynthetic pathway of the pigmented flavonoids.
leucoanthocyanidin biosynthetic process
The chemical reactions and pathways resulting in the formation of phlobaphenes, red pigments with oligomeric or polymeric structure derived from the flavonoid intermediate flavan-4-ols.
phlobaphene biosynthetic process
The chemical reactions and pathways resulting in the formation of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages.
pullulan biosynthetic process
The chemical reactions and pathways resulting in the breakdown of pullulan, a neutral linear polysaccharide composed of repeating units of maltotriose joined by alpha-(1,6)-linkages.
pullulan catabolic process
The breakage of covalent bonds to detach lipid groups from a protein.
protein delipidation
Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpN = S-adenosyl-L-homocysteine + DNA containing 5-MeCpN.
DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates
Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing CpNpG = S-adenosyl-L-homocysteine + DNA containing 5-MeCpNpG.
DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates
Binding to xanthophylls, any of several neutral yellow to orange carotenoid pigments containing oxygen.
xanthophyll binding
Catalysis of the reaction: divinyl protochlorophyllide a + NADPH + H+ = monovinyl protochlorophyllide a + NADP+.
3,8-divinyl protochlorophyllide a 8-vinyl reductase activity
Catalysis of the cyclization of 3(S)-oxidosqualene to (3S,13S,14R)-malabarica-8,17,21-trien-3-ol (thalianol).
thalianol synthase activity
The cell cycle process in which the centromeres of sister chromatids are physically detached from each other during meiosis.
meiotic sister chromatid centromere separation
Binding to a misfolded protein.
misfolded protein binding
The killing by an organism of a cell in its symbiont organism by means of the rupture of cell membranes and the loss of cytoplasm. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.
cytolysis by host of symbiont cells
Binding to methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
methotrexate binding
The directed movement of pigment granules within a cell towards the cell periphery.
pigment granule dispersal
The directed movement of dispersed pigment granules towards the center of the cell.
pigment granule aggregation in cell center
The cell cycle process in which lateral elements are formed. Axial elements form a proteinaceous core between the two sister chromatids of each chromosome; the two axial elements then connect along their entire lengths by fine fibers known as transverse filaments, forming the lateral elements.
lateral element assembly
Catalysis of the reaction: 3'-phosphoadenylyl sulfate + cholesterol = adenosine 3',5'-bisphosphate + cholesterol sulfate + H+.
cholesterol sulfotransferase activity
The directed movement of methotrexate, 4-amino-10-methylformic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase.
methotrexate transport
Binding to a light intermediate chain of the dynein complex.
dynein light intermediate chain binding
Catalysis of the reaction: di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho--N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H+ + UDP.
UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity
Catalysis of the reaction: di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP.
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity
Catalysis of the transfer of a methyl group to the phosphorus atom of an acceptor molecule.
P-methyltransferase activity
The assembly by an organism of a cellular component or anatomical structure for the purpose of obtaining nutrients from a symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.
formation by host of specialized structure for nutrient acquisition from symbiont
The directed movement of a motile cell or organism towards a lower concentration of environmental oxygen.
negative aerotaxis
The directed movement of a motile cell or organism towards a higher concentration of environmental oxygen.
positive aerotaxis
Any process in which an organism modulates the frequency, rate or extent of its symbiont's transcription.
modulation by host of symbiont transcription
The accumulation and maintenance in cells or tissues of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
carbohydrate storage
Catalysis of the reaction: ent-kaur-16-ene + 3 O2 + 3 reduced  = ent-kaur-16-en-19-oate + 4 H+ + 4 H2O + 3 oxidized .
ent-kaurene oxidase activity
Catalysis of the reaction: GTP + L-glutamate + factor F420-0 = GDP + H+ + factor gamma-F420-1 + phosphate.
coenzyme F420-0:L-glutamate ligase activity
Catalysis of the reaction: GTP + L-glutamate + factor gamma-F420-1 = GDP + H+ + factor gamma-F420-2 + phosphate.
coenzyme F420-1:gamma-L-glutamate ligase activity
Catalysis of the reaction: H2O + thymine + acceptor = 5-methyl-barbiturate + donor-H2.
thymine dehydrogenase activity
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+.
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
Catalysis of the reaction: epoxyqueuosine in tRNA + reductant = queuosine in tRNA + oxidised reductant.
epoxyqueuosine reductase activity
Catalysis of the reaction: jasmonoyl-isoleucine + NADPH + H+ + O2 = 12-hydroxy-jasmonoyl-isoleucine + NADP+ + H2O.
jasmonoyl-isoleucine-12-hydroxylase activity
Catalysis of the reaction: mannosyl-inositol phosphorylceramide + H2O = C26-phytoceramide + mannosylphosphorylinositol.
mannosyl-inositol phosphorylceramide phospholipase activity
Catalysis of the reaction: mannosyl-diinositol phosphorylceramide + H2O = C26-phytoceramide + mannosyldiphosphorylinositol.
mannosyl-diinositol phosphorylceramide phospholipase activity
Catalysis of the reaction: fatty acid + O2 + 2 NADPH + H+ = fatty acid with in-chain hydroxy group + 2 NADP+ + H2O.
fatty acid in-chain hydroxylase activity
Catalysis of the reaction: 1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP.
inositol hexakisphosphate 1-kinase activity
Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 3-diphospho-1D-myo-inositol (1,2,4,5,6)pentakisphosphate.
inositol hexakisphosphate 3-kinase activity
Catalysis of the reaction: gellan = n beta-D-4-deoxy-delta4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp. This reaction is the eliminative cleavage of beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyluronate bonds of gellan backbone, releasing tetrasaccharides containing a 4-deoxy-4,5-unsaturated D-glucopyranosyluronic acid at the non-reducing end; in the product, the abbreviations are D-glucose (Glc), D-glucuronic acid (GlcA), and L-rhamnose (Rha).
gellan lyase activity
Catalysis of the cleavage of a carbon-oxygen bond in ulvan, a carbohydrate composed of a repeating structure of n. Continued digest of ulvan with an enzyme that can catalyze this reaction results in ulvanobiouronic acid A 3-sulfate n with 4-deoxy-L-threo-hex-4-enopyranosiduronic acid at the non-reducing end.
ulvan lyase activity
Catalysis of the cleavage of glycosidic bonds through a beta-elimination reaction on alginate, a linear polysaccharide consisting of guluronate (G) and mannuronate (M) as the monomer constituents. An oligoalginate is a linear polymer of two, three or four units of (1->4)-alpha-L-guluronic acid and beta-D-mannuronic acid, releasing monosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends.
exo-oligoalginate lyase activity
Catalysis of the reaction: glucosyl-N-acetylglucosamine + H2O = glucosamine + N-acetylglucosamine.
glucosyl-N-acetylglucosamine glucosaminidase activity
The pathway resulting in the breakdown of diacetylchitobiose into simpler products, including glucosamine and glucosamine. The catabolism proceeds by the deacetylation of diacetylchitobiose, producing acetate and GlcN-GlcNAc; the latter is cleaved to produce glucosamine (GlcN) and N-acetylglucosamine (GlcNAc). The N-acetylglucosamine (GlcNAc) is then deacetylated to produce glucosamine (GlcN) and acetate.
diacetylchitobiose catabolic process to glucosamine and acetate
The chemical reactions and pathways resulting in the breakdown of any chitobiose, a family of compounds derived from chitin and based on the structure of D-glucosaminyl-(1->4)-D-glucosamine.
chitobiose catabolic process
Catalysis of the reaction: pectin + H2O = pectate + acetate. This reaction is the hydrolysis of acetyl esters of pectin, producing pectate, partially esterified pectin.
pectin acetylesterase activity
Catalysis of the cleavage of a carbon-oxygen bond in acharan sulfate, a glycosaminoglycan with a uniformly repeating disaccharide structure of alpha-D-N-acetylglucosaminyl-2-O-sulfo-alpha-L-iduronic acid.
acharan sulfate lyase activity
Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site.
DNA-7-methyladenine glycosylase activity
Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site.
DNA-3-methylguanine glycosylase activity