NothingMuch/GO-Terms huggingface dataset:
Binding to a gamma-tubulin complex.
gamma-tubulin complex binding
A complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins as part of the elongation of alpha 1,6-linked Man backbone. In S. cerevisiae, contains Mnn9p, Anp1p, Mnn10p, Mnn11p, and Hoc1p.
mannan polymerase II complex
A complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins as part of the priming and elongation of alpha 1,6-linked Man backbone. In S. cerevisiae, contains Mnn9p and Van1p.
mannan polymerase I complex
Any process that modulates the frequency, rate or extent of microlipophagy, the microautophagy-mediated direct internalization of lipid droplets into a lysosome-like vacuole during nutrient depletion.
regulation of microlipophagy
The organization of a polarized cell layer during morphogenesis in protozoa; an example is found during culmination in D. discoideum, involving alpha and beta catenins.
epithelium-like organization
Either of the regions of a mitotic nuclear bridge proximal to the main portion of each daughter nucleus. The nuclear envelope in the stalk regions is depleted of nuclear pore complexes.
mitotic nuclear bridge stalk
A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the mitotic nuclear bridge during closed mitosis.
mitotic nuclear bridge organization
A process that results in the assembly of a cytoplasmic viral factory consisting of a double-membrane bound vesicle.
double membrane vesicle viral factory assembly
The aggregation, arrangement and bonding together of a set of components to form the CMG complex, a protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. The process begins when additional proteins (e.g. Cdc45 and Sld3) join the loaded, inactive double MCM hexamer at replication origins, and ends when Mcm10 triggers the separation of the Mcm2-7 double hexamers, forming two active CMG complexes.
CMG complex assembly
A molecular function regulator that increases the activity of a transcription regulator via direct binding and/or post-translational modification.
transcription regulator activator activity
A process that prevents a zygote from fusing an additional cell.
negative regulation of conjugation with zygote
Any process that stops, prevents or reduces the frequency, rate or extent of melanotic encapsulation of foreign target.
negative regulation melanotic encapsulation of foreign target
Any process that increases the frequency, rate or extent of the synthesis of piRNA.
positive regulation of piRNA transcription
The acquisition of seed longevity is the ordered series of events during seed development, that prevent embryo deterioration and ROS damage and thus contribute to seed viability over time or in response to adverse environmental conditions. These events include protective (e.g. production of glassy cytoplasm ) and repair (e.g. oxidative stress responses) processes.
acquisition of seed longevity
Catalyzes the reaction: UDP-alpha-D-xylose + -3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine = UDP + -3-O-(alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine. The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)- beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF- like) domains.
xylosyl alpha-1,3-xylosyltransferase activity
Catalysis of the reaction: UDP-alpha-D-glucose + -L-serine = UDP + -3-O-(beta-D-glucosyl)-L-serine.
EGF-domain serine glucosyltransferase activity
Catalyses the reaction: UDP-alpha-D-xylose + -L-serine = UDP + -3-O-(beta-D-xylosyl)-L-serine.
EGF-domain serine xylosyltransferase activity
Catalyzes the reaction: UDP-alpha-D-xylose + -3-O-(beta-D-glucosyl)-L-serine = UDP + -3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine.
UDP-D-xylose:beta-D-glucoside alpha-1,3-D-xylosyltransferase activity
The removal of a mislocalized protein from the endoplasmic reticulum (ER) membrane.
extraction of mislocalized protein from ER membrane
The division of a vacuole within a cell to form two or more separate vacuoles.
vacuole fission
Oxidation of monodehydroascorbate outside of a membrane coupled to the reduction of L-ascorbate to monodehydro-L-ascorbate radical on the inner side of a membrane. Electrons get transferred across the membrane during the reaction.
transmembrane monodehydroascorbate reductase activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu+(in) = ADP + phosphate + Cu+(out).
P-type monovalent copper transporter activity
The process by which large macromolecular complexes are budded through the inner nuclear membrane, into the perinuclear space, thus acquiring a membrane envelope. The enveloped particle fuses with the outer nuclear membrane and is released into the cytoplasm.
nuclear envelope budding
Stops, prevents or reduces the activity of xyloglucan-specific endo-beta-1,4-glucanase.
xyloglucan-specific endo-beta-1,4-glucanase inhibitor activity
Binding to and carrying a lipoprotein between two different cellular locations by moving along with the target lipoprotein.
lipoprotein carrier activity
A nuclear membrane part at the midzone of the mitotic nuclear bridge. The midzone forms a bulge that is enriched in nuclear pores that lack baskets.
mitotic nuclear bridge midzone membrane domain
The chemical reactions and pathways resulting in the formation of the coenzyme mycofactocin, a variably glycosylated small molecule electron pair carrier derived from the C-terminal valine-tyrosine dipeptide of the ribosomally translated precursor peptide MftA.
mycofactocin biosynthetic process
A motor activity driven by an electrochemical proton gradient (proton-motive force). PMF-driven motors are used by bacterial flagella.
proton motive force-driven motor activity
Binding to a specific RNA molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.
RNA sequestering activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(in) = ADP + H+ + Mn2+(out) + phosphate.
P-type manganese transporter activity
Binds to and increases a DNA strand exchange activity.
DNA strand exchange activator activity
Binds to and stops, prevents or reduces a DNA strand exchange activity.
DNA strand exchange inhibitor activity
Lipid transfer complex that is responsible for the non-vesicular transport of phospholipids, such as phosphatidylserine, from the endoplasmic reticulum to the endosome. It resides in the endosomal (acceptor) membrane and binds to specific lipids on the donor membrane at the ER-endosome contact site.
ER-to-endosome phospholipid transfer complex
The protein catabolic pathway which selectively extracts ER-resident membrane proteins exported to the Golgi and endosomes for degradation by cytosolic proteasomes. It begins with phosphorylation of the ER-resident membrane protein, which triggers export of the protein from the ER to the Golgi and endosomes, followed by polyubiquitination by the Dsc E3 ubiquitin ligase complex and extraction of the ubiquitinated target, and ends with proteasomal degradation.
EGAD pathway
The series of molecular signals generated as a consequence of an opioid growth factor receptor binding to its physiological ligand, opioid growth factor (OGF, met-enkephalin). The OGF-OGFr complex leads to the increase in the synthesis of the selective cyclin-dependent kinase (CDK) inhibitor proteins, p12 (POLD4) and p16 (CDKN2A).
opioid growth factor receptor signaling pathway
Binds to and stops, prevents, or reduces the activity of an outwardly rectifying potassium channel.
outward rectifier potassium channel inhibitor activity
Binds to and stops, prevents, or reduces the activity of a small conductance calcium-activated potassium channel.
small conductance calcium-activated potassium channel inhibitor activity
Binds to and stops, prevents or reduces the activity of aldehyde dehydrogenase (NAD+).
aldehyde dehydrogenase (NAD+) inhibitor activity
The aggregation, arrangement and bonding together of a set of components to form a CARD8 inflammasome complex.
CARD8 inflammasome complex assembly
An inflammasome complex that consists of CARD8 and CASP1.
CARD8 inflammasome complex
The movement of a neutrophil away from the site of wound or infection following its initial migration to the site.
neutrophil dispersal
The process in which copper is transported from the cytosol into the mitochondrial matrix.
copper import into the mitochondrion
The spindle organization process in which the spindle is maintained at a constant length during meiotic metaphase.
meiotic spindle formation (spindle phase two)
Any process that stops, prevents or reduces the frequency, rate or extent of the process leading up to expression of the pre-B cell receptor on the surface of pre-B cells.
negative regulation of pre-B cell receptor expression
Any process that activates or increases the frequency, rate or extent of mitotic to meiotic cell cycle switching, the process in which a cell switches cell cycle mode from mitotic to meiotic division.
positive regulation of cell cycle switching, mitotic to meiotic cell cycle
The phosphorylation and dephosphorylation of creatine in a futile cycle, which dissipates the high energy charge of phosphocreatine as heat without performing any mechanical or chemical work. The futile creatine cycle takes place in thermogenic fat cells and is part of adaptive thermogenesis.
futile creatine cycle
Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.
ATP-dependent protein folding chaperone
Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis.
ATP-dependent FeS chaperone activity
Any process that activates or increases the frequency, rate or extent of production of oxytocin.
positive regulation of oxytocin production
Any process that stops, prevents, or reduces the rate of production of oxytocin.
negative regulation of oxytocin production
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na(in) = ADP + phosphate + Na(out).
ABC-type sodium transporter activity
A heteromultimeric complex capable of dihydropyrimidine dehydrogenase (NAD+); in E. coli, composed of PreA and PreT.
dihydropyrimidine dehydrogenase (NAD+) complex
Binding to an RNA or an RNA-containing complex to assist the folding process.
RNA folding chaperone
Catalysis of the reaction: an omega-methyl-very-long-chain fatty acid + O2 + reduced  = an omega-hydroxy-very-long-chain fatty acid + H+ + H2O + oxidized . A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons.
very long-chain fatty acid omega-hydroxylase activity
A protein-containing complex localization by which the complex is transported to, or maintained in, the centriolar satellite.
protein-containing complex localization to centriolar satellite
The C-terminal elongation of 60S-anchored stalled nascent polypeptide chains with untemplated alanine and threonine tails (CAT tails). CAT tails participate in the recognition of stalled nascent chains by the ribosome quality control system.
CAT tailing
A protein complex that assists early maturation of nascent 60S ribosomal subunits. The complex interacts with the large ribosomal subunit rRNA via one of the components (Urb2 in S. cerevisiae) and requires a RNA helicase (Dbp6 in S. cerevisiae).
large ribosomal subunit pre-assembly complex
A heterodimeric enzyme complex that catalyzes the ligation of serine to tRNA(Ser), forming L-seryl-tRNA(Ser).
serine-tRNA ligase complex
Entry of a symbiont into host plant tissue via the stromata, microscopic pores in the epidermis of the aerial parts of terrestrial plants. These pores are essential for photosynthesis, as they allow CO2 to diffuse into the plant. The host is defined as the larger of the organisms involved in a symbiotic interaction.
entry into host through the stromata
Heterochromatin that is located adjacent to the telomere, and characterized by methylated H3 histone at lysine 9 (H3K9me2/H3K9me3).
subtelomeric heterochromatin
Binds to and increases the activity of a tRNA ligase.
tRNA ligase activator activity
An inflammasome complex that consists of NLRP6, PYCARD/ASC and caspase-1 or caspase-4/caspase-11.
NLRP6 inflammasome complex
The aggregation, arrangement and bonding together of a set of components to form a NLRP6 inflammasome complex.
NLRP6 inflammasome complex assembly
Catalysis of the reaction: L-arginyl- + NAD+ = ADP-riboxanated L-argininyl- + H+ + NH4(+) + nicotinamide.
ADP-riboxanase activity
Any process that decreases the frequency, rate or extent of the synthesis of a lncRNA.
negative regulation of lncRNA transcription
The transcription of a small interfering RNA from an RNA template.
siRNA transcription
The chemical reactions and pathways resulting in the breakdown of small interfering RNA transcripts (siRNAs).
siRNA catabolic process
Any process that activates or increases the frequency, rate or extent of ascospore wall (1->3)-beta-D-glucan biosynthetic process.
positive regulation of regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process
Catalysis of the reaction: phlorizin + H2O = beta-D-glucose + phloretin.
phlorizin hydrolase activity
Catalysis of the reaction: UDP-glucose + (n) = UDP + a branched (n+1).
branched 1,3-beta-D-glucan synthase activity
Catalysis of the reaction: UDP-glucose + (n) = UDP + a linear (n+1).
linear 1,3-beta-D-glucan synthase activity
A process in intracellular membranes are reorganized by viral proteins that perturb membrane integrity and can cause an extensive rearrangement of cellular membranes, forming membranous webs, which are thought to be the site of replication or certain viruses, for example the HPV virus.
reorganization of cellular membranes to establish viral sites of replication
A process in which a virus triggers host intracellular membranes to be reorganized, forming membranous webs, which are thought to be the site of replication or certain viruses, for example the HPV virus.
reorganization of host cellular membranes to establish sites of replication
The action of a molecule that contributes to the structural integrity of the proteasome.
structural constituent of proteasome
An thiol-dependent isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated.
cysteine-type deNEDDylase activity
An metal-dependent isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated.
metal-dependent deNEDDylase activity
Catalysis of the reaction: a quinone + D-glucose = a quinol + D-glucono-1,5-lactone.
glucose dehydrogenase (FAD, quinone) activity
A programmed DNA elimination mechanism in which specific sequences, namely, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the genome. This process is known to occur in ciliates.
programmed DNA elimination by elimination of internal DNA segments
A translational repressor activity that binds to a single-stranded small regulatory RNA (either a miRNA or a siRNA) to guide it to its target mRNA.
small RNA binding translational repressor activity
An enzyme-substrate adaptor that bings together a protein ADP-ribosyl transferase and its substrate.
protein ADP-ribosyltransferase-substrate adaptor activity
Catalysis of the reaction: L-lysyl- + tetradecanoyl- = H+ + holo- + N(6)-tetradecanoyl-L-lysyl-.
ACP-dependent peptidyl-lysine N6-myristoyltransferase activity
Catalysis of the reaction: L-lysyl- + tetradecanoyl-CoA = CoA + H+ + N(6)-tetradecanoyl-L-lysyl-.
CoA-dependent peptidyl-lysine N6-myristoyltransferase activity
Catalysis of the reaction: hexadecanoyl- + L-lysyl- = H+ + holo- + N(6)-hexadecanoyl-L-lysyl-.
ACP-dependent peptidyl-lysine N6-palmitoyltransferase activity
Catalysis of the reaction: L-lysyl- + hexadecanoyl-CoA = CoA + H+ + N(6)-hexadecanoyl-L-lysyl-.
CoA-dependent peptidyl-lysine N6-palmitoyltransferase activity
Catalysis of the reaction: N6-tetradecanoyl-L-lysyl- + NAD+ + H2O = tetradecanoyl-ADP-D-ribose + L-lysyl- + nicotinamide.
NAD-dependent protein demyristoylase activity
Catalysis of the reaction: N6-octadecanoyl-L-lysyl- + NAD+ + H2O = octadecanoyl-ADP-D-ribose + L-lysyl- + nicotinamide.
NAD-dependent protein depalmitoylase activity
A protein-containing complex stabilizing activity that prevents dissociation of microtubules.
microtubule stabilizing activity
Catalysis of the active transport of a phosphate ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.
phosphate ion uniporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + H+(in) = glycine(in) + H+(out).
glycine:proton antiporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4-aminobutanoate(out) + H+(in) = 4-aminobutanoate(in) + H+(out).
gamma-aminobutyric acid:proton antiporter activity
Catalysis of the reaction: -C-terminal glycine + NAD+ = -C-terminal O-(ADP-D-ribosyl)-glycine + nicotinamide.
NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity
Catalysis of the reaction: L-cysteinyl- + NAD+ = H+ + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-.
NAD+-protein-cysteine ADP-ribosyltransferase activity
Catalysis of the reaction: L-lysyl- + NAD+ = H+ + N(6)-(ADP-D-ribosyl)-L-lysyl- + nicotinamide.
NAD+-protein-lysine ADP-ribosyltransferase activity
Catalysis of the reaction: L-aspartyl- + NAD+ = 4-O-(ADP-D-ribosyl)-L-aspartyl- + nicotinamide.
NAD+-protein-aspartate ADP-ribosyltransferase activity
Catalysis of the reaction: L-tyrosyl- + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-.
NAD+-protein-tyrosine ADP-ribosyltransferase activity
Catalysis of the reaction: L-histidyl- + NAD+ = H+ + Nt-(ADP-D-ribosyl)-L-histidyl- + nicotinamide.
NAD+-protein-histidine ADP-ribosyltransferase activity
Enables the transfer of UDP-beta-L-arabinofuranose from one side of a membrane to the other.
UDP-beta-L-arabinofuranose transporter activity
Enables the transfer of zinc from one side of a membrane to the other according to the reaction: H+(out) + Zn2+(in) = H+(in) + Zn2+(out).
zinc:proton antiporter activity
Binding to and delivering zinc ions to a target protein.
zinc chaperone activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-glutamine(out) + Na+(out) = H+(out) + L-glutamine(in) + Na+(in).
L-glutamine, sodium:proton antiporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-asparagine(out) + Na+(out) = H+(out) + L-asparagine(in) + Na+(in).
L-asparagine, sodium:proton antiporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(in) + L-histidine(out) + Na+(out) = H+(out) + L-histidine(in) + Na+(in).
L-histidine, sodium:proton antiporter activity
Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine (position 5).
RNA polymerase II C-terminal domain S5 O-GlcNAc transferase activity
Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + RNA polymerase II large subunit CTD heptapeptide repeat (YSPTSPS) = UDP + RNA polymerase II large subunit CTD heptapeptide repeat 3-O-(N-acetyl-D-glucosaminyl)-L-serine (position 7).
RNA polymerase II C-terminal domain S7 O-GlcNAc transferase activity
A process that activates or increases the frequency, rate or extent of the transition from the initiation to the elongation phases of transcription by RNA polymerase II.
positive regulation of promoter clearance from RNA polymerase II promoter
A process that stops, prevents or reduces the transition from the initiation to the elongation phases of transcription by RNA polymerase II.
negative regulation of promoter clearance from RNA polymerase II promoter
Binds to and stops, prevents or reduces the activity of RNA polymerase.
RNA polymerase inhibitor activity
Binds to and stops, prevents or reduces the activity of an RNA polymerase inhibitor.
repressor of RNA polymerase inhibitor activity
Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of the fungal metabolite terrein.
positive regulation terrein biosynthetic process
Any process that activates or increases the frequency, rate or extent of the controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
positive regulation of nucleosome disassembly
The disruption of nucleosomes during DNA replication to allow the replication machinery to access the DNA.
DNA replication-dependent chromatin disassembly
Combining with a mechanical force and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
mechanoreceptor activity
A chromatin remodeling process in which CENP-A is removed from euchromatin regions to prevent neocentromere formation.
CENP-A eviction from euchromatin
The process in which a plastid gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
plastid gene expression
A process which results in the assembly, arrangement of constituent parts, or disassembly of a cytoophidium. Cytoophidia are mesoscale, intracellular, filamentous structures that contain metabolic enzymes.
cytoophidium organization
Catalysis of the reaction: R-CH + a halogen + FADH2 + O2 = R-C-halogen + FAD + H2O.
flavin-dependent halogenase activity
A complex consisting of ADAM17 in complex with regulatory iRhoms and FERM domain containing proteins.
iRhom2/ADAM17 sheddase complex
The dissemination of mature viral particles from a host cell, caused by a virus hydrolyzing the peptidoglycan cell wall of the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls.
viral release via disruption of host peptidoglycan cell wall
The directed import of zinc(2+) from the cytosol, across an organelle membrane, into a zymogen granule.
zinc ion import into zymogen granule
The directed import of zinc(2+) from the cytosol, across an organelle membrane, into a lysosome.
zinc ion import into lysosome
The directed import of zinc(2+) from the cytosol, across an organelle membrane, into a mitochondrion.
zinc ion import into mitochondrion
Any process that stops, prevents or reduces the frequency, rate or extent of thermomorphogenesis.
negative regulation of thermomorphogenesis
Any process that increases the rate, frequency or extent of thermomorphogenesis.
positive regulation of thermomorphogenesis
The directed movement of L-kynurenine across a membrane.
L-kynurenine transmembrane transport
The directed movement of L-phenylalanine from outside of a cell, across the plasma membrane and into the cytosol.
L-phenylalanine import across plasma membrane
Enables the transfer of L-kynurenine from one side of a membrane to the other.
L-kynurenine transmembrane transporter activity
Enables the transfer of cyclic-di-GMP from one side of a membrane to the other.
cyclic-di-GMP transmembrane transporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-mannose(out) + Na+(out) = D-mannose(in) + Na+(in).
mannose:sodium symporter activity