NothingMuch/GO-Terms huggingface dataset:
Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate.
inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity
Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate.
inositol hexakisphosphate 2-phosphatase activity
Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate.
inositol-3,4-bisphosphate 4-phosphatase activity
Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate.
inositol-1,3,4-trisphosphate 1-phosphatase activity
Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate.
inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity
Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate.
inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity
Catalysis of the reaction: 1D-myo-inositol 3-phosphate + H2O = myo-inositol + phosphate.
inositol monophosphate 3-phosphatase activity
Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol pentakisphosphate = ADP + 5-triphospho-1D-myo-inositol pentakisphosphate.
inositol 5-diphosphate pentakisphosphate 5-kinase activity
Catalysis of the reaction: 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+.
inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity
Catalysis of the reaction: 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + H+.
inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
Catalysis of the reaction: 1,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + H+.
inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
Catalysis of the reaction: 3,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H+.
inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
Catalysis of the reaction: curcumin + NADPH + H+ = dihydrocurcumin + NADP+.
NADPH-dependent curcumin reductase activity
Catalysis of the reaction: protein-lysine + protein-lysine = protein N6-(lysyl)-L-lysine + protein. This reaction is the addition of lysine group from one protein to a lysine residue in a second protein, producing N6-(lysyl)-L-lysine.
protein-lysine lysyltransferase activity
Catalysis of the reaction: an aromatic (S)-hydroxynitrile = an aromatic aldehyde + cyanide.
aromatic (S)-hydroxynitrile lyase activity
Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(966) in 16S rRNA = N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine.
16S rRNA (guanine(966)-N(2))-methyltransferase activity
Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(2445) in 23S rRNA = N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine.
23S rRNA (guanine(2445)-N(2))-methyltransferase activity
Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine.
23S rRNA (guanine(1835)-N(2))-methyltransferase activity
Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)--beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.
dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity
The lipid bilayer surrounding a virion.
virion membrane
The lipid bilayer surrounding a recycling endosome.
recycling endosome membrane
A crystalline exocytotic organelle composed of small, acidic proteins existing primarily as disulphide-linked dimers. The trichocyst is an organelle that releases long filamentous proteins that capture predators in net-like structures, to slow them down when the cell is disturbed. The protein is nontoxic and shaped like a long, striated, fibrous shaft.
trichocyst
Flagellar filaments located in the periplasmic space; characterized in spirochetes, in which they are essential for shape and motility. Composed of a core surrounded by two sheath layers, the flagella rotate to allow migration of the cell through viscous media, which would not be possible using external flagella.
periplasmic flagellum
Catalysis of the reaction: 5-valerolactone + H2O = 5-hydroxyvalerate.
5-valerolactone hydrolase activity
Catalysis of the reaction: 5-oxovalerate + NADP+ + H2O = glutarate + NADPH + H+.
5-oxovalerate dehydrogenase activity
The process in which the antipodal cells undergo programmed cell death.
antipodal cell degeneration
The process in which the generative cell divides by mitosis to form two haploid cells. These will subsequently differentiate into sperm cells.
generative cell mitosis
A complex for the transport of metabolites out of the cell, consisting of 4 domains: two ATP-binding domains and two membrane spanning domains. In some cases, all 4 domains are contained on 1 polypeptide, while in others one ATP-binding domain and one membrane spanning domain are together on one polypeptide in what is called a half transporter. Two half-transporters come together to form a functional transporter. Transport of the substrate across the membrane is driven by the hydrolysis of ATP.
ATP-binding cassette (ABC) transporter complex, integrated substrate binding
A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP.
ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
The process resulting in the physical partitioning and separation of a neuroblast into two equi-potent daughter cells.
symmetric neuroblast division
Any process resulting in the physical partitioning and separation of a neuroblast into a neuroblast and a ganglion mother cell.
asymmetric neuroblast division resulting in ganglion mother cell formation
A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p.
Ski complex
Any process involved in the maintenance of an internal steady state of fatty acid within an organism or cell.
fatty acid homeostasis
Any process involved in the maintenance of an internal steady state of phospholipid within an organism or cell.
phospholipid homeostasis
Binding to adiponectin, a protein hormone produced by adipose tissue that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism.
adiponectin binding
Binds to and stops, prevents or reduces the activity of a ligase.
ligase inhibitor activity
The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex.
Golgi to secretory granule transport
The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis.
Golgi to transport vesicle transport
The infolding of the epithelial sheet into the embryo involved in deuterostomic gastrulation.
invagination involved in gastrulation with mouth forming second
The inturning of an epithelial sheet over the basal surface of an outer layer involved in deuterostomic gastrulation.
involution involved in gastrulation with mouth forming second
The migration of individual cells into the embryo involved in deuterostomic gastrulation.
ingression involved in gastrulation with mouth forming second
The splitting or migration of one epithelial sheet into two involved in the process of deuterostomic gastrulation.
delamination involved in gastrulation with mouth forming second
A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.
striated muscle dense body
The transmission of vibrations via ossicles to the inner ear.
vibrational conductance of sound to the inner ear
Binding to a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway.
C3HC4-type RING finger domain binding
A vestibular reflex by which a response to an angular acceleration stimulus begins with an afferent nerve impulse from a receptor in the semi-circular canal and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness.
angular vestibuloocular reflex
A vestibular reflex by which a response to a linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the otolith and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness.
linear vestibuloocular reflex
The process in which the cellular identity of Sertoli cells is acquired and determined.
Sertoli cell fate commitment
The multiplication or reproduction of Sertoli cells, resulting in the expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules.
Sertoli cell proliferation
The cell fate commitment of precursor cells that will become granulosa cells.
granulosa cell fate commitment
The process whose specific outcome is the progression of a granulosa cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a granulosa cell fate.
granulosa cell development
The process in which neuroepithelial cells of the neural tube give rise to Brgmann glial cells, specialized bipotential progenitors cells of the cerebellum. Differentiation includes the processes involved in commitment of a cell to a specific fate.
Bergmann glial cell differentiation
Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell.
regulation of synaptic activity
The directed migration of individual cells and small groups of cells toward the dorsal midline during gastrulation. This process does not require cell rearrangement.
dorsal convergence
The interdigitation of cells along the mediolateral axis during gastrulation.
mediolateral intercalation
The developmental process in which the structure of the notochord is destroyed in an embryo.
notochord regression
The assembly and arrangement of a vacuole within a cell of the notochord.
notochord cell vacuolation
Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons.
neurofilament cytoskeleton
Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury.
positive regulation of epithelial cell proliferation involved in wound healing
The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage.
embryonic retina morphogenesis in camera-type eye
The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the post-embryonic life stage.
post-embryonic retina morphogenesis in camera-type eye
The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure.
vagina development
The assembly, arrangement, or disassembly of cytoskeletal structures that is involved in the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
cytoskeletal rearrangement involved in phagocytosis, engulfment
The extracellular matrix part that is a regularly spaced indentation in the outer cortical layer of the cuticle. The pattern of annular furrows corresponds to sites of invaginations in hypodermal cell membranes that, in turn, correspond to submembranous regions where actin microfilament bundles assemble early in lethargus, the first phase of the molting cycle in which activity and feeding decline.
annular furrow extracellular matrix
Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell.
positive regulation of growth hormone secretion
Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell.
negative regulation of growth hormone secretion
A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother.
embryonic process involved in female pregnancy
A reproductive process occurring in the embryo that results in birth.
fetal process involved in parturition
The process whose specific outcome is the progression of the urinary bladder over time, from its formation to the mature structure. The urinary bladder is an elastic, muscular sac situated in the anterior part of the pelvic cavity in which urine collects before excretion.
urinary bladder development
The process controlling the timing and/or rate at which a relatively unspecialized cell in the subpallium acquires features of a neuron. The subpallium is the base region of the telencephalon.
regulation of timing of subpallium neuron differentiation
The biological process whose specific outcome is the progression of the olfactory pit from an initial condition to its mature state. This process begins with the formation of the olfactory pit, which is an indentation of the olfactory placode, and ends when the pits hollows out to form the nasopharynx.
olfactory pit development
The portion of the plasma membrane surrounding a stereocilium.
stereocilium membrane
Combining with the peptide apelin to initiate a change in cell activity.
apelin receptor activity
The opening and spreading out of the outer ear.
outer ear unfolding
Any process that increases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein.
positive regulation of protein desumoylation
Any process that decreases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein.
negative regulation of protein desumoylation
Any process that decreases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA.
negative regulation of antisense RNA transcription
Any process that increases the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA.
positive regulation of antisense RNA transcription
The estrous cycle phase which is a period of sexual quiescence and represents the phase of the mature corpus luteum.
diestrus
The estrous cycle phase in which there is heightened follicular activity.
proestrus
The estrous cycle phase in which there is subsiding follicular function.
metestrus
Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.
endocardium formation
The process in which a relatively unspecialized cell acquires the characteristics of a mature hemangioblast. Hemangioblasts are the proposed common precursor of blood and endothelial lineages.
hemangioblast cell differentiation
Any process that increases the process in which the developmental fate of a cell becomes restricted such that it will develop into a retinal rod cell. A retinal rod cell is one of the two photoreceptor subtypes in a camera-type eye.
positive regulation of retinal rod cell fate commitment
Binds to and increases the activity of a lipoprotein lipase, an enzyme that catalyzes of the hydrolysis of a lipid within a lipoprotein.
lipoprotein lipase activator activity
The negative regulation of cell adhesion process in which an oenocyte splits off of an existing epithelial sheet.
oenocyte delamination
The negative regulation of cell adhesion process in which a neuroblast splits off of a neurectodermal sheet.
neuroblast delamination
Signaling at short range between the head ectoderm and the optic vesicle that results in the head ectoderm forming a lens.
lens induction in camera-type eye
Binds to and stops, prevents or reduces the activity of lysozyme.
lysozyme inhibitor activity
The negative regulation of cell growth in response to increased cell density.
negative regulation of cell growth involved in contact inhibition
Any process that stops, prevents or reduces the rate or extent of cell proliferation in response to cell density.
negative regulation of cell proliferation involved in contact inhibition
Any process that decreases the rate frequency or extent of the covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein.
negative regulation of N-terminal protein palmitoylation
The cell migration process in which a follicle cell migrates as part of an epithelial sheet between the nurse cells and the oocyte. At the end of migration, they cover the anterior of the oocyte.
centripetally migrating follicle cell migration
The ovarian follicle cell migration process in which follicle cells migrate posteriorly to form a columnar epithelium over the oocyte.
main body follicle cell migration
The behavior in which an organism sheds tears, often accompanied by non-verbal vocalizations and in response to external or internal stimuli.
crying behavior
The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to limited nutrients in the environment.
maintenance of stationary phase in response to starvation
The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction in response to a build-up of toxins in the environment.
maintenance of stationary phase in response to toxin
Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary.
positive regulation of ovulation
Any process that stops, prevents, or reduces the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary.
negative regulation of ovulation
Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
positive regulation of oocyte development
Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
negative regulation of oocyte development
A homeostatic process involved in the maintenance of a compartment boundary. A compartment boundary is a lineage restriction boundary within a developing tissue which does not correspond to some morphological barrier.
compartment boundary maintenance
Any process that increases the rate, frequency or extent of the activity of a molecule that controls the survival, growth, differentiation and effector function of tissues and cells.
positive regulation of cytokine activity
Binds to and modulates the activity of GTP cyclohydrolase I. GTP cyclohydrolase I activity catalyzes the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.
GTP cyclohydrolase I regulator activity
Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
negative regulation of ryanodine-sensitive calcium-release channel activity
Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
positive regulation of ryanodine-sensitive calcium-release channel activity
The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head.
face morphogenesis
The membrane surrounding the inner segment of a vertebrate photoreceptor. The photoreceptor inner segment contains mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
photoreceptor inner segment membrane
Any process that decreases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism.
negative regulation of cell adhesion molecule production
Any process that increases the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism.
positive regulation of cell adhesion molecule production
Self-propelled movement of an organism from one location to another through the air that is part of the organism's response to external or internal stimuli resulting in flight.
flight involved in flight behavior
The process in which the coronal suture is generated and organized.
coronal suture morphogenesis
The process in which the lambdoid suture is generated and organized.
lambdoid suture morphogenesis
The process in which the sagittal suture is generated and organized.
sagittal suture morphogenesis
The process of causing a cell to become susceptible to T cell mediated cytotoxicity.
susceptibility to T cell mediated cytotoxicity
Any process that increases the rate, frequency or extent of mast cell differentiation, the process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation.
positive regulation of mast cell differentiation