NothingMuch/GO-Terms huggingface dataset:
A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; complex formation is implicated in activation of calcineurin by SOD1.
SOD1-calcineurin complex
A process that modulates the length of a microvillus on a follicle cell.
regulation of follicle cell microvillus length
A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p.
CURI complex
Binding to a purine deoxyribonucleoside, a compound consisting of a purine base linked to deoxyribose.
purine deoxyribonucleoside binding
Binding to a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose.
pyrimidine deoxyribonucleoside binding
Binding to a pyrimidine ribonucleoside, a compound consisting of a pyrimidine base linked to ribose.
pyrimidine ribonucleoside binding
Binding to a pyrimidine deoxyribonucleotide, any compound consisting of a pyrimidine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety.
pyrimidine deoxyribonucleotide binding
Binding to dAMP, deoxyadenosine monophosphate.
dAMP binding
Binding to dADP, deoxyadenosine diphosphate.
dADP binding
Binding to dATP, deoxyadenosine triphosphate.
dATP binding
Binding to dGMP, deoxyguanosine monophosphate.
dGMP binding
Binding to dGDP, deoxyguanosine diphosphate.
dGDP binding
Binding to dGTP, deoxyguanosine triphosphate.
dGTP binding
The lipid bilayer surrounding an aleurone grain.
aleurone grain membrane
A fibrous network that is part of the hyalin layer extracellular matrix. The apical lamina is thought to be principally composed of the glycoproteins fibropellins. This matrix has been found in echinoderms.
apical lamina of hyaline layer
The portion of the plasma membrane surrounding a growth cone.
growth cone membrane
The lipid bilayer surrounding a protein storage vacuole.
protein storage vacuole membrane
Binding to a protein or protein complex, in the presence of copper.
copper-dependent protein binding
Binding to lead (Pb) ions.
lead ion binding
Binding to a heterotrimeric G-protein.
heterotrimeric G-protein binding
The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye.
lacrimal gland development
The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a backup mechanism to ensure the segregation of homologs that have failed to cross over - either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) - but nevertheless segregate normally.
distributive segregation
Binding to calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid.
calcitonin binding
Catalysis of the reaction: 2 RSH + ROOH = RSSR + ROH + H2O. This reaction is the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol.
hydroperoxide reductase activity
Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion.
regulation of karyogamy
The modification of spermidine by addition of acetyl groups.
spermidine acetylation
The modification of spermine by addition of acetyl groups.
spermine acetylation
The modification of putrescine by addition of acetyl groups.
putrescine acetylation
A complex consisting of 4 protein subunits as a heterotetramer, that possesses sarcosine oxidase activity.
sarcosine oxidase complex
A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) in the ER membrane.
SREBP-SCAP-Insig complex
Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
negative regulation of translation in response to oxidative stress
Binds transmembrane domain-containing proteins and mediates their integration into a membrane.
membrane insertase activity
A change in the morphology or behavior of a keratinocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. Upon activation, keratinocytes become migratory and hyperproliferative, and produce growth factors and cytokines.
keratinocyte activation
An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluK1-3 (also called GluR5-7), GluK4 (KA1) and GluK5 (KA2) subunits.
kainate selective glutamate receptor complex
The disaggregation of a protein-carbohydrate complex into its constituent components.
protein-carbohydrate complex disassembly
A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus.
Bcl3-Bcl10 complex
A small, vestigial nucleus found in some plastids that derive from a eukaryotic endosymbiont. Observed in chlorarachniophytes and cryptomonads, which acquired their plastids from a green and red alga respectively.
nucleomorph
A permanent cup-shaped structure at the cell plasma membrane in secretory cells. Following a secretory stimulus, secretory vesicles transiently dock and fuse at the base of porosomes and release intravesicular contents dictated by the turgor pressure generated from the swelling of secretory vesicles.
porosome
The lipid bilayer surrounding a rhoptry.
rhoptry membrane
Catalysis of the reaction: 5-hydroxyvalerate + NAD+ = 5-oxovalerate + NADH.
5-hydroxyvalerate dehydrogenase activity
Enables the transmembrane transfer of an ion by a channel that opens when a soluble salty compound has been bound by the channel complex or one of its constituent parts.
ionotropic salty taste receptor activity
Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste.
sour taste receptor activity
Combining with soluble umami compounds to initiate a change in cell activity. These receptors are responsible for the sense of umami taste, the savory taste of meats and other foods that are rich in glutamates.
umami taste receptor activity
A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses.
Weibel-Palade body
The inner, i.e. lumen-facing, lipid bilayer of the amyloplast envelope; also faces the amyloplast stroma.
amyloplast inner membrane
The lipid bilayer surrounding an acidocalcisome.
acidocalcisome membrane
The lipid bilayer surrounding an attachment organelle. This is a region of the cell membrane facing the environment - in mycoplasma, part of the mycolate outer membrane.
attachment organelle membrane
The volume enclosed by a cyanelle thylakoid membrane.
cyanelle thylakoid lumen
The lipid bilayer membrane of any thylakoid within a cyanelle.
cyanelle thylakoid membrane
The lipid bilayer surrounding an esterosome. This membrane has characteristics of rough endoplasmic reticulum (RER) membranes.
esterosome membrane
Binding to an acetylcholine receptor.
acetylcholine receptor binding
Binding to a ubiquitin activating enzyme, any of the E1 proteins.
ubiquitin activating enzyme binding
Binding to a FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family.
FFAT motif binding
A large cytoskeletal structure located at the posterior end of the perinuclear theca of a mammalian sperm head. The nucleus is tightly associated with the calyx, which contains calicin and basic cylicin proteins.
cytoskeletal calyx
The directed movement of oligogalacturonides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
oligogalacturonide transport
The lipid bilayer surrounding a melanosome.
melanosome membrane
The lipid bilayer surrounding a microneme.
microneme membrane
Catalysis of the cyclization of double bonds in prosolanapyrone II to form (-)-solanapyrone A.
solanapyrone synthase activity
Catalysis of the reaction: a 2-pyrone + oxalacetate = macrophomate.
macrophomate synthase activity
A homohexameric protein complex that possesses DNA helicase activity; associates with DNA polymerase alpha-primase and translocates in the 5' to 3' direction.
DNA helicase A complex
Binding to urea, a water-soluble carboxamide with the structure H2N-CO-NH2.
urea binding
Binding to the D- or L-enantiomer of xylose.
xylose binding
The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
dsRNA transport
The directed movement of carbohydrates out of a cell or organelle.
carbohydrate export
Any process that modulates the frequency, rate or extent of beta-lactamase activity, the hydrolysis of a beta-lactam to yield a substituted beta-amino acid.
regulation of beta-lactamase activity
A multimeric protein complex that acts as an endosomal tethering complex (CORVET = class C core vacuole/endosome tethering) by cooperating with Rab GTPases to capture endosomal vesicles and trap them prior to the action of SNAREs; the complex is involved in endo-lysosomal biogenesis and required for transport between endosome and vacuole. The Saccharomyces cerevisiae complex contains Vps8p, Vps3p, Pep5p, Vps16p, Pep3p, and Vps33p.
CORVET complex
Binding to choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium.
choline binding
A protein complex that does not contain either a TATA-binding protein (TBP) or a TBP-like factor, but is composed of several TAFIIs and other proteins, including a histone acetyltransferase. This complex is able to nucleate transcription initiation by RNA polymerase II, can mediate transcriptional activation, and has histone acetyltransferase activity.
transcription factor TFTC complex
A microtubule located such that it threads through the conoid and projects through the polar ring.
intraconoid microtubule
A protein complex composed of the large and small ribosomal subunits, methionyl-initiatior tRNA, and the capped mRNA. The initiator tRNA is positioned at the ribosomal P site at the AUG codon corresponding to the beginning of the coding region.
eukaryotic 80S initiation complex
Binding to ectoine, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid.
ectoine binding
Binding to hydroxyectoine.
hydroxyectoine binding
Binding to the D- or L-enantiomer of rhamnose.
rhamnose binding
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a Leydig cell. A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis.
Leydig cell differentiation
The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-aspartate.
asparagine catabolic process via L-aspartate
The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxosuccinamate.
asparagine catabolic process via 2-oxosuccinamate
A cyclic series of interconversions involving chlorophyll a, chlorophyll b and several chlorophyllide intermediates.
chlorophyll cycle
A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).
chromatoid body
A ubiquitin ligase complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp6, Shf1, Brl2/Rfp1 and Brl1/Rfp2.
HULC complex
A cyclic series of interconversions involving S-methyl-L-methionine, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, L-homocysteine, and L-methionine. Converts the methionine group of adenosylmethionine back to free methionine, and may serve regulate the cellular adenosylmethionine level.
S-methylmethionine cycle
A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on odd-numbered carbons are degraded. In this pathway, a cis-3-enoyl-CoA is generated by the core beta-oxidation pathway, and then converted to a trans-2-enoyl-CoA, which can return to the core beta-oxidation pathway for complete degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
fatty acid beta-oxidation, unsaturated, odd number
A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to trans-2-enoyl-CoA by 2,4-dienoyl-CoA reductase and delta3-delta2-enoyl-CoA isomerase; trans-2-enoyl-CoA returns to the core beta-oxidation pathway for further degradation. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
fatty acid beta-oxidation, unsaturated, even number, reductase/isomerase pathway
A fatty acid beta-oxidation pathway by which fatty acids having cis-double bonds on even-numbered carbons are degraded. In this pathway, the intermediate 2,4-dienoyl-CoA is converted to cis-2-enoyl-CoA through one more cycle of the core beta-oxidation pathway. Cis-2-enoyl-CoA cannot be completely degraded via the core beta-oxidation pathway because hydratation of cis-2-enoyl-CoA yields D-3-hydroxyacyl-CoA, which is not a substrate for 3-hydroxylacyl-CoA dehydrogenase. Cis-2-enoyl-CoA must enter the so-called epimerase pathway, which involves converting D-3-hydroxyacyl-CoA to L-3-hydroxyacyl-CoA by 3-hydroxylacyl-CoA epimerase or by two stereo-specific enoyl-CoA hydratases. L-3-hydroxyacyl-CoA then returns to the core beta-oxidation pathway. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
fatty acid beta-oxidation, unsaturated, even number, epimerase pathway
A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes.
Slx1-Slx4 complex
Catalysis of the reaction: 7,8-dihydrofolate + NADP+ = folate + NADPH + H+.
folate reductase activity
Combining with lactoferrin and delivering lactoferrin into the cell via endocytosis. Lactoferrin is an iron-binding glycoprotein which binds ferric iron most efficiently at low pH.
lactoferrin receptor activity
Enables the transfer of lactoferrin from one side of a membrane to the other.
lactoferrin transmembrane transporter activity
The directed movement of lactoferrin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
lactoferrin transport
An activity that facilitates the formation of a complementary double-stranded RNA molecule.
RNA strand annealing activity
A heterodimeric protein complex formed of BRCA2 and MAGE-D1; may mediate the synergistic activities of the two proteins in regulating cell growth.
BRCA2-MAGE-D1 complex
A heterodimeric protein complex formed of superoxide dismutase 1 and Bcl-2. Complex formation is thought to link superoxide dismutase to an apoptotic pathway.
SOD1-Bcl-2 complex
The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the chloroplast thylakoid membrane.
chloroplast proton-transporting ATP synthase complex assembly
The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane.
mitochondrial proton-transporting ATP synthase complex assembly
The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the plasma membrane.
plasma membrane proton-transporting ATP synthase complex assembly
Any sac-like membranous structures (cisternae) in a chloroplast found in host cells, combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. The host is defined as the larger of the organisms involved in a symbiotic interaction.
host cell chloroplast thylakoid membrane
A membrane-bounded vesicle found near the apical, or pericanalicular, membrane of a hepatocyte; contains proteins involved in bile salt transport and other fluid and solute transport processes.
pericanalicular vesicle
A nuclear ubiquitin ligase complex that specifically targets SUMOylated proteins; the complex is formed of homodimers or heterodimers of RNF4 family ubiquitin ligases and is conserved in eukaryotes.
SUMO-targeted ubiquitin ligase complex
A region in the lower half of some cells formed from extensive infoldings of the basal plasma membrane; includes cytoplasm adjacent to the infolded membrane.
basal labyrinth
Catalysis of the reaction: 5-hydroxymethylfurfural + NAD(P)H + H+ = 2,5-bis-hydroxymethylfuran + NAD(P)+.
hydroxymethylfurfural reductase activity
Catalysis of the reaction: 5-hydroxymethylfurfural + NADH + H+ = 2,5-bis-hydroxymethylfuran + NAD+.
hydroxymethylfurfural reductase (NADH) activity
Catalysis of the reaction: 5-hydroxymethylfurfural + NADPH + H+ = 2,5-bis-hydroxymethylfuran + NADP+.
hydroxymethylfurfural reductase (NADPH) activity
The chemical reactions and pathways involving furaldehyde, a furan ring-containing aldehyde compound which can be formed from the thermal decomposition of biomass.
furaldehyde metabolic process
Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + 5beta-scymnol = 5beta-scymnol sulfate + adenosine 3',5'-diphosphate + H+.
scymnol sulfotransferase activity
Catalysis of the endonucleolytic cleavage of RNA, removing 3'-extranucleotides from tRNA precursor.
ribonuclease P4 activity
The volume enclosed by the membranes of an acidocalcisome.
acidocalcisome lumen
A protein complex that forms a coat structure on vesicles involved in exocytosis of proteins from the trans-Golgi network to the cell surface; in Saccharomyces, the complex contains Chs5p, Chs6p, and Chs6p paralogues.
exomer complex
Facilitates the displacement of one strand of an RNA-RNA duplex and its replacement with a different strand of higher complementarity.
RNA strand-exchange activity
The space enclosed by the double membrane of a cyanelle.
cyanelle stroma
A protein complex that contains the transcription factor Ste11 and the RNA binding protein Mei2; involved in regulation of conjugation in fission yeast.
Tor2-Mei2-Ste11 complex
Catalysis of the reaction: acetyl-CoA + aminoglycoside = CoA + 1-N-acetylaminoglycoside. This is acetylation of the 1-amino group of the central deoxystreptamine ring.
aminoglycoside 1-N-acetyltransferase activity
Catalysis of the reaction: squalene = tetrahymanol.
tetrahymanol cyclase activity
Catalysis of the reaction: oxidosqualene = marneral.
marneral synthase activity
Catalysis of the reaction: oxidosqualene + H2O = arabidiol ((13R,14R,17E)-malabarica-17,21-diene-3beta,14-diol).
arabidiol synthase activity
Catalysis of the reaction: oxidosqualene = cucurbitadienol.
cucurbitadienol synthase activity
The process in which the sister chromatids of a replicated chromosome become joined along the entire length of the chromosome during S phase during a meiotic cell cycle.
establishment of meiotic sister chromatid cohesion
A multiprotein complex that recognizes ERAD-luminal misfolded substrates and brings them to the ubiquitination/extraction machinery. In yeast, this complex consists of Yos9p, Kar2p and Hrd3p proteins.
luminal surveillance complex
Binding to apolipoprotein A-I.
apolipoprotein A-I binding
Combining with an apolipoprotein A-I receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
apolipoprotein A-I receptor activity
Binding to an apolipoprotein A-I receptor.
apolipoprotein A-I receptor binding
The translocation, or flipping, of glycolipid molecules from one monolayer of a membrane bilayer to the opposite monolayer.
glycolipid translocation
A protein-DNA complex formed by the association of a distinct set of general and specific transcription factors with a region of enhancer DNA. The cooperative assembly of an enhanceosome confers specificity of transcriptional regulation.
enhanceosome
GTP dependent catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate.
GTP-dependent protein kinase activity
Any process that stops, prevents, or decreases the frequency, rate or extent of macrophage fusion.
negative regulation of macrophage fusion
Any process that activates or increases the frequency, rate or extent of macrophage fusion.
positive regulation of macrophage fusion
The process of removing sections of a primary snoRNA transcript to remove sequences not present in the mature form of the snoRNA and joining the remaining sections to form the mature form of the snoRNA.
snoRNA splicing
Enables the transfer of nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, from one side of a membrane to the other.
nicotinamide riboside transmembrane transporter activity
The directed movement of a nicotinamide riboside, which is a pyridine-3-carboxamide covalently bonded to a ribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
nicotinamide riboside transport
A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p.
Atg12-Atg5-Atg16 complex
Catalysis of the reaction: ent-copalyl diphosphate = ent-isokaurene + diphosphate.
ent-isokaurene synthase activity
The process in which oidia, a type of asexual spore found in fungi, are formed. Oidia are borne a few at a time on very simple hyphae that protrude a short distance into the substrate, and are usually presumed not to constitute the main reproductive strategy of the fungus.
oidium formation