NothingMuch/GO-Terms huggingface dataset:
Catalysis of the active transport of purine nucleotides across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.
purine nucleotide uniporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(in) + sulfate(out) = chloride(out) + sulfate(in).
sulfate:chloride antiporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: chloride(out) + oxalate(in) = chloride(in) + oxalate(out).
oxalate:chloride antiporter activity
Catalysis of the reaction: ATP + muramyl dipeptide = ADP + H+ + 6-O-phospho-muramyl dipeptide.
muramyl dipeptide kinase activity
The process of fusing together the edges of a craniofacial suture.
craniofacial suture closure
Any process that stops, prevents or reduces the frequency, rate or extent of cGAS/STING signaling pathway.
negative regulation of cGAS/STING signaling pathway
Binding to xanthine, a purine base.
xanthine binding
The mitotic cell cycle process in which the nuclear envelope, including nuclear pores, is equally distributed to the two daughter cells during the mitotic cell cycle.
mitotic nuclear envelope segregation
Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphoseryl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a serine in the active site.
serine-based site-specific recombinase activity
The aggregation, arrangement and bonding together of microfibril.
microfibril assembly
A protein complex composed of at least GAP45 (gliding-associated protein), GAP50 and myosin heavy and light chains. Anchored via GAP50 to the inner membrane complex of motile and invasive forms of apicomplexan parasites and regulates parasite gliding motility and invasion of host cells.
glideosome
The lipid bilayer surrounding a macropinosome.
macropinosome membrane
The process in which a cell becomes capable of differentiating autonomously into a plant endodermal cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.
plant endodermal cell fate specification
The process in which a relatively unspecialized cell acquires specialized features of a plant endodermal cell.
plant endodermal cell differentiation
A homeostatic process in which the drive for sleep increases sleep propensity with prolonged wakefulness.
sleep homeostasis
A homeostatic process by which the sensing of CO2 and/or H+ by the brain leads to appropriate altering in breathing to regulate blood gas and tissue pH.
respiratory chemosensitivity
A process of protein insertion of multi-pass membrane proteins into the endoplasmic reticulum (ER) membrane. Insertion of multi-pass membrane proteins is mediated by the multi-pass translocon complex and takes place following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex to promote insertion of subsequent transmembrane regions.
multi-pass transmembrane protein insertion into ER membrane
The regulated release of surfactant by a cell or tissue.
surfactant secretion
The regulation of double fertilization forming a zygote and endosperm process that ensures that only a single sperm cell fertilizes one egg cell and another single sperm cell fertilizes one central cell.
prevention of polyspermy during double fertilization
An inflammasome complex containing CASP4, known as caspase-11 (Casp11) in mouse, which assembles upon cytosolic lipopolysaccharide-binding and directly activates Gasdermin-D (GSDMD).
non-canonical inflammasome complex
Any process that stops, prevents or reduces the frequency, rate or extent of non-canonical inflammasome complex assembly.
negative regulation of non-canonical inflammasome complex assembly
Any process that stops, prevents, or reduces the frequency, rate or extent of lipid droplet fusion.
negative regulation of lipid droplet fusion
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + indole(in) = ADP + phosphate + indole(out).
ABC-type indole transporter activity
Enables the energy-independent facilitated diffusion of iodide through a transmembrane aqueous pore or channel.
iodide channel activity
A process in which a protein is transported to, or maintained in, a location within a polar microtubule.
protein localization to polar microtubule
The process of removing the majority of the cytoplasm and organelles from a spermatid as it develops into a mature flagellated sperm cell.
spermatid cytoplasm removal during spermiation of flagellated sperm
A protein adaptor that recognizes and binds an RNA molecule modified by N(7)-methylguanine (m7G), a modification present at internal sites of mRNAs and some non-coding RNAs.
internal N(7)-methylguanine-containing RNA reader activity
Catalysis of the reaction: a guanosine in mRNA + S-adenosyl-L-methionine = an N(7)-methylguanosine in mRNA + S-adenosyl-L-homocysteine.
internal mRNA (guanine-N7-)-methyltransferase activity
Formation of circular RNAs (circRNAs) by back-splicing circularization of pre-mRNAs in a spliceosome-dependent process.
spliceosome-depend formation of circular RNA
A protein-containing complex involved in hemoglobin degradation and detoxification of heme in the food vacuole during the asexual blood stage of a Plasmodium. It is composed of at least falcipains FP2A and/or FP2B, plasmepsins PMII, PMIII/HAP and PMIV, heme detoxifying protein HDP and falcilysin FLN.
hemozoin formation complex
The process whose specific outcome is the progression of insect pharynx over time, from its formation to the mature structure.
insect pharynx development
The process whose specific outcome is the progression of the nematode pharyngeal muscle over time, from its formation to the mature structure.
nematode pharyngeal muscle development
Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle, is driven by ATP hydrolysis.
reverse gyrase activity
A structural network of microtubule inner proteins (MIPs) located inside the lumen of the A tubule of the axonemal microtubule doublet that helps stabilize the A tubule.
axonemal A tubule inner sheath
A structural network of microtubule inner proteins (MIPs) located inside the lumen of the B tubule of the axonemal microtubule doublet that helps stabilize the B tubule.
axonemal B tubule inner sheath
The structure which joins the B10 protofilament of the B tubule to the A1 protofilament of the A tubule within an axonemal microtubule doublet.
axonemal microtubule doublet inner junction
The structure which joins the B1 protofilament of the B tubule to the A10 and A11 protofilaments of the A tubule within an axonemal microtubule doublet.
axonemal microtubule doublet outer junction
The 3 protofilaments A11, A12, and A13 of the A tubule along with associated inner sheath microtuble inner proteins (MIPs), either in the lumen of the A tubule or of the B tubule, which stabilize these three filiments within the axonemal doublet microtubule. The ribbon protofilaments separate the lumens of the A and B tubules.
axonemal microtubule doublet ribbon
Catalysis of the reaction: guanosine(7) in tRNA + S-adenosyl-L-methionine = H+ + N(2)-methylguanosine(7) in tRNA + S-adenosyl-L-homocysteine.
tRNA (guanine(7)-N2)-methyltransferase activity
A programmed cell death process that is induced by intracellular copper accumulation.
cuproptosis
Catalysis of the reaction: 2 3-acyl-sn-glycero-1-phospho-(1'-sn-glycerol) = 3-acyl-sn-glycero-1-phospho-(3'-acyl-1'-sn-glycerol) + sn-glycero-1-phospho-(1'-sn-glycerol).
bis(monoacylglycero)phosphate synthase activity
The process in which a relatively unspecialized cell acquires specialized features of an corneal epithelial cell, any of the cells making up an corneal epithelium.
corneal epithelial cell differentiation
The action of a molecule that contributes to the structural integrity of nuclear lamina.
structural constituent of nuclear lamina
Binds to and increases the activity of a guanyl nucleotide exchange factor.
guanyl nucleotide exchange factor activator activity
A process that rescues stalled ribosomes by removing the covalent cross-link between RNA and a protein.
protein-RNA covalent cross-linking repair
Catalysis of the cross-link between a protein and a DNA abasic site, forming a thiazolidine linkage between a DNA ring-opened abasic site and the alpha-amino and sulfhydryl substituents of cysteine residue of the protein.
protein-DNA covalent cross-linking activity
A protein complex that consists of RNA guanine-7 methyltransferase (RNMT) and RNA guanine-7 methyltransferase activating subunit (RAMAC) and is involved in mRNA cap methylation.
mRNA cap methyltransferase RNMT:RAMAC complex
A cell part that is composed of multifold plasma membrane of the epidermis where it is in direct contact with apical extracellular matrix. Meisosome, or multiple eisome is named because of its superficial similarity to yeast eisosome.
meisosome
A protein adaptor activity characterized by the capacity to selectively recognize and interact with RNA molecules in a sequence-specific manner. Entities possessing this activity typically exhibit discerning binding preferences for specific nucleotide sequences within RNA molecules, enabling the identification and engagement of distinct RNA motifs or structural elements. This function is integral to various biological processes, including RNA processing, transport, and regulatory mechanisms, contributing to the specificity and precision of cellular RNA-related activities.
protein-RNA sequence-specific adaptor activity
A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by endothelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
phospholipase C-activating endothelin receptor signaling pathway
Catalysis of the reaction: uridine(516) in 16S rRNA = pseudouridine(516) in 16S rRNA.
16S rRNA pseudouridine(516) synthase activity
Catalysis of the reaction: uridine(2457) in 23S rRNA = pseudouridine(2457) in 23S rRNA.
23S rRNA pseudouridine(2457) synthase activity
Catalysis of the reaction: uridine(2604) in 23S rRNA = pseudouridine(2604) in 23S rRNA.
23S rRNA pseudouridine(2604) synthase activity
Catalysis of the reaction: uridine(2605) in 23S rRNA = pseudouridine(2605) in 23S rRNA.
23S rRNA pseudouridine(2605) synthase activity
Catalysis of the reaction: uridine(1911/1915/1917) in 23S rRNA = pseudouridine(1911/1915/1917) in 23S rRNA.
23S rRNA pseudouridine(1911/1915/1917) synthase activity
Catalysis of the reaction: uridine(955/2504/2580) in 23S rRNA = pseudouridine(955/2504/2580) in 23S rRNA.
23S rRNA pseudouridine(955/2504/2580) synthase activity
Catalysis of the reaction: uridine(746) in 23S rRNA = pseudouridine(746) in 23S rRNA.
23S rRNA pseudouridine(746) synthase activity
Catalysis of the reaction: uridine(2819) in 21S rRNA = pseudouridine(2819) in 21S rRNA.
21S rRNA pseudouridine(2819) synthase activity
Any process that stops, prevents or reduces the frequency, rate or extent of GDF15-GFRAL signaling pathway.
negative regulation of GDF15-GFRAL signaling pathway
Catalysis of the reaction: uridine(55) in tRNA = pseudouridine(55) in tRNA.
tRNA pseudouridine(55) synthase activity
Catalysis of the reaction: uridine(65) in tRNA = pseudouridine(65) in tRNA.
tRNA pseudouridine(65) synthase activity
Catalysis of the reaction: uridine(13) in tRNA = pseudouridine(13) in tRNA.
tRNA pseudouridine(13) synthase activity
Catalysis of the reaction: uridine(32) in tRNA = pseudouridine(32) in tRNA.
tRNA pseudouridine(32) synthase activity
Catalysis of the reaction: uridine(31) in tRNA = pseudouridine(31) in tRNA.
tRNA pseudouridine(31) synthase activity
Catalysis of the reaction: uridine(27/28) in mitochondrial tRNA = pseudouridine(27/28) in mitochondrial tRNA.
mitochondrial tRNA pseudouridine(27/28) synthase activity
Catalysis of the reaction: uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA.
tRNA pseudouridine(38/39) synthase activity
The cellular process that results in the fusion of secretory granules with lysosomes to form crinosomes.
secretory granule-lysosome fusion
Any process that activates or increases the frequency, rate or extent of N-acetylmuramic acid catabolic process.
positive regulation of N-acetylmuramic acid catabolic process
Any process that activates or increases the frequency, rate or extent of nicotine catabolic process.
positive regulation of nicotine catabolic process
Any process that activates or increases the frequency, rate or extent of propanediol catabolic process.
positive regulation of propanediol catabolic process
The series of molecular signals initiated by the binding of the cell surface receptor CD27 to its physiological ligand CD70, and ending with the regulation of a downstream cellular process, e.g. transcription.
CD27 signaling pathway
Catalysis of the reaction: H+ + NADPH + S-nitrosoglutathione = NADP+ + S-(hydroxysulfenamide)glutathione.
S-nitrosoglutathione reductase (NADPH) activity
Any process that stops, prevents or reduces the frequency, rate or extent of chromatin looping.
negative regulation of chromatin loopin
Catalysis of the reaction: 2-oxoadipate + H+ + N(6)--L-lysyl- = CO2 + N(6)--L-lysyl-.
2-oxoadipate dehydrogenase activity
The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=9 symmetry. The T=9 capsid is composed of 12 pentameric and 80 hexameric capsomeres.
T=9 icosahedral viral capsid
The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=21 or pseudo T=21 symmetry.
T=21/pseudo21 icosahedral capsid
The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=27 or pseudo T=27 symmetry.
T=27/pseudo27 icosahedral capsid
The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=28 symmetry.
T=28 icosahedral capsid
The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=31 or pseudo T=31 symmetry.
T=31/pseudo31 icosahedral capsid
A cellular developmental process by which the outer layer of the cell (the cortex) rotates relative to the inner cytoplasm.
cortical rotation
The developmental process in which a somatic muscle attaches to the chitin-based cuticle. In insects, this may occur via a specialized epithelial cell adherence to the chitinous extracellular matrix and to muscle cells through their basement membrane.
somatic muscle attachment to chitin-based cuticle
The directed movement of magnesium ion from cytosol to endoplasmic reticulum.
magnesium ion transport from cytosol to endoplasmic reticulum
Any process that activates or increases the rate which autophagosomes fuse with a vacuole (yeast) or lysosome (e.g. mammals and insects).
positive regulation of autophagosome-lysosome fusion
Catalysis of the transport of a dipeptide across a membrane; transport is independent of the movement of any other molecular species.
dipeptide uniporter activity
A process in which iron is taken up from the contents of the intestine.
intestinal iron absorption
The chemical reactions and pathways resulting in the formation of piperine.
piperine biosynthetic process
The directed movement of substance through the space in between adjacent cells, rather than through the cells themselves.
paracellular transport
Binds to and increases the activity of the enzyme phospholipase C.
phospholipase C activator activity
Binds to and stops, prevents or reduces the activity of the enzyme phospholipase C.
phospholipase C inhibitor activity
The binding activity of a molecule that brings together the peroxisome and the mitochondrial outer membrane, establishing the localization of the peroxisome close to the mitochondrion.
peroxisome-mitochondrion membrane tether activity
Binds to and stops, prevents or reduces the activity of L-lactate dehydrogenase.
L-lactate dehydrogenase inhibitor activity
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a sensory hair cell stereocilium bundle.
stereocilium bundle organization
Catalysis of the reaction: ditrans,polycis-polyprenol + NAD(P) = ditrans,polycis-polyprenal+ NAD(P)H + H+.
polyprenol dehydrogenase activity
Catalysis of the reaction: ditrans,polycis-dolichal+ H+ + NAD(P)H = ditrans,polycis-dolichol+ NAD(P).
dolichal reductase activity
Catalysis of the reaction: ditrans,polycis-polyprenal+ H+ + NADPH = ditrans,polycis-dolichal+ NADP.
polyprenal reductase activity
Any process that activates or increases the frequency, rate or extent of 7-methylguanosine mRNA capping.
positive regulation of 7-methylguanosine mRNA capping
A membrane-bounded organelle found in a microsporidian spore,  that swells with water, and exerts pressure to rupture the polar cap and evert the polar tube through which the sporoplasm escapes to infect the host.
polaroplast
A structural component of the microsporidian spore's invasion apparatus that is located at the anterior end of the spore and serves to attach the polar tube to the inside of the spore wall.
polar tube anchoring disc
Any process that activates or increases the frequency, rate or extent of androgen receptor signaling.
positive regulation of androgen receptor signaling pathway
A protein-containing complex that contains the fragile X mental retardation protein (FMRP) and cytoplasmic FMRP Interacting protein 1 (CYIFIP1), and is capable of inhibiting translation initiation by binding to the eIF4F complex.
FMRP-CYFIP1 complex
Catalysis of the reaction: L-serine + succinyl-CoA = CoA + O-succinyl-L-serine.
L-serine O-succinyltransferase activity
Any of the lipid bilayers that surround an apicoplast and form the apicoplast envelope.
apicoplast membrane
Enables the transmembrane transfer of a cation by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
glycine-gated cation channel activity
A beta-arrestin-dependent signaling pathway initiated by a dopamine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.
beta-arrestin-dependent dopamine receptor signaling pathway
The binding activity of a molecule that brings together a plasma membrane with an endoplasmic reticulum membrane, via membrane lipid binding, to establish membrane contact sites and mediate exchange and communication.
endoplasmic reticulum-plasma membrane adaptor activity
Catalysis of the reaction: H2O + N6-lactoyl-L-lysyl- = (S)-lactate + L-lysyl-.
protein lysine delactylase activity
Any process that stops, prevents or reduces the frequency, rate or extent of transcription initiation-coupled chromatin remodeling.
negative regulation of transcription initiation-coupled chromatin remodeling
Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate.
negative regulation of acetyl-CoA biosynthetic process from pyruvate
Enables the transfer of ergothioneine from one side of a membrane to the other.
ergothioneine transmembrane transporter activity
Enables the transfer of heme B from one side of a membrane to the other.
heme B transmembrane transporter activity
Enables the transfer of lipoate from one side of a membrane to the other.
lipoate transmembrane transporter activity
Binds to and increases the activity of cyclic nucleotide phosphodiesterase.
cyclic nucleotide phosphodiesterase activator activity
The process in which lipoate is transported across a membrane.
lipoate transmembrane transport
The binding activity of a molecule that brings together a lipid droplet with an endoplasmic reticulum membrane, via membrane lipid binding, to establish membrane contact sites and mediate exchange and communication.
endoplasmic reticulum-lipid droplet tether activity
Binds to and increases the activity of mRNA phosphatase.
mRNA phosphatase activator activity
A molecule that recognizes stalled ribosomes and initiates a signaling response.
stalled ribosome sensor activity
Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl- + NAD+ = 2''-O-(2E)-but-2-enoyl-ADP-D-ribose + L-lysyl- + nicotinamide.
histone H3K18 decrotonylase activity
A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
channel complex
Combining with carbon dioxide to initiate a change in cell activity.
carbon dioxide receptor activity
The binding activity of a molecule that brings together an endosome and an ER membrane either via membrane lipid binding or by interacting with an endosome protein, to establish and facilitate organelle exchange.
endoplasmic reticulum-endosome tether activity
Enables the transmembrane transfer of an ion by a channel that opens when a specific odorant has been bound by the channel complex or one of its constituent parts.
ionotropic olfactory receptor activity
Enables the transmembrane transfer of an ion by a channel that opens when a specific bitter compound has been bound by the channel complex or one of its constituent parts.
ionotropic bitter taste receptor activity
Enables the transmembrane transfer of an ion by a channel that opens when a specific soluble sweet compound has been bound by the channel complex or one of its constituent parts.
ionotropic sweet taste receptor activity
The process in which isopentenyl pyrophosphate is transported across a membrane into the mitochondrion.
isopentenyl pyrophosphate import into mitochondrion
A ribonucleoprotein complex containing a box C/D type snoRNA and three (Archaea) or four (Eukaryotes) core proteins that is capable of methylation of target RNAs.
box C/D methylation guide RNP complex
A ribonucleoprotein complex containing a small CB-specific RNA (scaRNA), with a short sequence motif (GU/UG wobble stem) for CB localization that is capable of methylation of target RNAs.
box C/D methylation guide scaRNP complex
A ribonucleoprotein complex containing a box C/D type RNA that is involved in pre-rRNA cleavage.
box C/D pre-rRNA cleavage RNP complex
Directly binding to and delivering nickel ions to a target protein.
nickel chaperone activity
Binds to and stops, prevents or reduces the activity of a histone methyltransferase.
histone methyltransferase inhibitor activity
Catalysis of the reaction: S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) = S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out).
S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity
Any process by which dormant, translationally inactive mRNAs become activated, or mRNAs become stabilized, via the elongation of their poly(A) tails in the cytosol.
cytosolic mRNA polyadenylation
Catalysis of the movement of a lysophosphatidylserine from the exoplasmic to the cytosolic leaflet of a membrane, using energy from the hydrolysis of ATP.
lysophosphatidylserine flippase activity
The directed movement of nucleoside from outside of a cell, across the plasma membrane and into the cytosol.
nucleoside import across plasma membrane
Binds to and modulates the activity of a SUMO ligase.
SUMO ligase regulator activity
Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys11 residue of ubiquitin.
K11-linked deubiquitinase activity
A kinetochore subcomplex that binds to centromeric chromatin and forms part of the outer kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans and yeast respectively, it consists of KNL1/Spc105p and ZWINT/Kre28p.
Knl1/Spc105 complex