NothingMuch/GO-Terms huggingface dataset:
One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state.
COPII vesicle coat
A clathrin coat found on a synaptic vesicle.
clathrin coat of synaptic vesicle
A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary.
bacteriocin immunity
Structural change in proteins which destroys the native, active configuration without rupture of peptide bonds.
protein denaturation
Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
pyridoxal phosphate binding
Binding to troponin C, the calcium-binding subunit of the troponin complex.
troponin C binding
Enables the transfer of nitric oxide, nitrogen monoxide, from one side of a membrane to the other.
nitric oxide transmembrane transporter activity
The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
nitric oxide transport
Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP.
deoxynucleotide transmembrane transporter activity
The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle.
skeletal muscle thin filament assembly
The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle.
skeletal muscle myosin thick filament assembly
Binding to cellulose.
cellulose binding
Binds to and stops, prevents or reduces the activity of guanylate cyclase.
guanylate cyclase inhibitor activity
Covalent attachment of a glycosyl residue to a lipid molecule.
lipid glycosylation
Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions.
LIM domain binding
The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers.
structural constituent of cutaneous appendage
A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits.
protein phosphatase 4 complex
Binds to and stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase.
transmembrane receptor protein tyrosine kinase inhibitor activity
Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase.
transmembrane receptor protein tyrosine kinase activator activity
The directed movement of a deoxynucleotide, a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of deoxyribose, into, out of or within a cell.
deoxynucleotide transport
The directed movement of chloride ions from one side of an epithelium to the other.
transepithelial chloride transport
The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
stabilization of membrane potential
Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.
cyclin binding
The action of a molecule that contributes to the structural integrity of tooth enamel.
structural constituent of tooth enamel
Binding to a syntaxin-3 SNAP receptor.
syntaxin-3 binding
Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate.
inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate.
inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity
The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals.
melanin-concentrating hormone activity
Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis.
molybdopterin synthase activity
Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues.
ICAM-3 receptor activity
Catalysis of the synthesis of free D-serine from L-serine.
serine racemase activity
The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects.
chorion-containing eggshell pattern formation
Binding to lactose, a disaccharide of glucose and galactose, the carbohydrate of milk.
lactose binding
A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence.
competence pheromone activity
The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form.
yeast-form cell wall
The cell wall surrounding a fungal hypha.
hyphal cell wall
Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae.
actin cap
Electron-dense region associated with a smooth muscle contractile fiber.
smooth muscle dense body
Catalysis of the reaction: 1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.
inositol-4,5-bisphosphate 5-phosphatase activity
Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.
ankyrin binding
Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.
spectrin binding
The action of a molecule that contributes to the structural integrity of chromatin.
structural constituent of chromatin
The process in which copies of the 2-micrometer plasmid, found in fungi such as Saccharomyces, are distributed to daughter cells upon cell division.
2-micrometer plasmid partitioning
Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.
Hsp70 protein binding
Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased.
acetylcholine receptor activator activity
Binds to and stops, prevents or reduces the activity of an acetylcholine receptor.
acetylcholine receptor inhibitor activity
Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue.
rRNA pseudouridylation guide activity
Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue.
tRNA pseudouridylation guide activity
Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue.
rRNA 2'-O-ribose methylation guide activity
Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule.
snRNA 2'-O-ribose methylation guide activity
Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue.
tRNA 2'-O-ribose methylation guide activity
Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule.
snRNA pseudouridylation guide activity
A process that occurs during the first cell cycle in an embryo, in which anterior cortical contractions culminate in a single partial constriction of the embryo called the pseudocleavage furrow. An example of this process is found in nematode worms.
first cell cycle pseudocleavage
The covalent attachment of an ADP-ribosyl group to a residue in double-stranded DNA.
DNA ADP-ribosylation
Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin disulfide is also known as oxidized thioredoxin.
arsenate reductase (thioredoxin) activity
Binding to a U1 small nuclear RNA (U1 snRNA).
U1 snRNA binding
Binding to a U2 small nuclear RNA (U2 snRNA).
U2 snRNA binding
Binding to a U4 small nuclear RNA (U4 snRNA).
U4 snRNA binding
Binding to a U4atac small nuclear RNA (U4atac snRNA).
U4atac snRNA binding
Binding to a U5 small nuclear RNA (U5 snRNA).
U5 snRNA binding
Binding to a U6atac small nuclear RNA (U6atac snRNA).
U6atac snRNA binding
Binding to a U11 small nuclear RNA (U11 snRNA).
U11 snRNA binding
Binding to a U12 small nuclear RNA (U12 snRNA).
U12 snRNA binding
The lipid bilayer surrounding a chitosome.
chitosome membrane
The lipid bilayer surrounding a dense granule of the type found in apicomplexan parasites.
merozoite dense granule membrane
The lipid bilayer surrounding a clathrin-coated phagocytic vesicle.
clathrin-coated phagocytic vesicle membrane
A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis.
Noc1p-Noc2p complex
A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis.
Noc2p-Noc3p complex
Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C.
glycine reductase complex
Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster.
germarium-derived female germ-line cyst encapsulation
Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster.
follicle cell of egg chamber stalk formation
The increase in volume of an oocyte during the growth phase of the egg chamber, once the egg chamber has left the germarium. An example of this process is found in Drosophila melanogaster.
oocyte growth in germarium-derived egg chamber
Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state.
GTP-dependent protein binding
Any chromosome other than a sex chromosome.
autosome
A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit.
RENT complex
Binding to beta-2-microglobulin.
beta-2-microglobulin binding
Binding to an endogenous cellular lipid antigen.
endogenous lipid antigen binding
Binding to an exogenous lipid antigen (examples include microbial lipids and glycolipids).
exogenous lipid antigen binding
Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+).
calcium-dependent ATPase activity
The post-translational removal of peptide sequences from within a protein sequence, by a process not involving inteins.
non-intein-mediated protein splicing
The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity.
olfactory placode formation
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a deep water stimulus, being immersed in standing deep water throughout the life cycle.
response to deep water
A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans.
Smc5-Smc6 complex
The acetylation of peptidyl-serine to form peptidyl-O-acetyl-L-serine.
peptidyl-serine O-acetylation
A protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity. Examples of this component are found in Bacterial species.
homotetrameric ADPG pyrophosphorylase complex
An ADPG pyrophosphorylase complex found in the amyloplast.
amyloplast ADPG pyrophosphorylase complex
An ADPG pyrophosphorylase complex found in the chloroplast.
chloroplast ADPG pyrophosphorylase complex
A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices span the plasma membrane and associate with hemidesmosomes and the basal lamina where they bind laminin.
collagen type XVII trimer
A collagen homotrimer of alpha1(XVIII) chains.
collagen type XVIII trimer
Binding to a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast.
chloroplast targeting sequence binding
Binding to a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum.
DDEL sequence binding
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. This reaction requires metal ions.
protein tyrosine phosphatase activity, metal-dependent
Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures.
establishment or maintenance of actin cytoskeleton polarity
The 'de novo' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule.
astral microtubule nucleation
Binding to Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus.
Tat protein binding
A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing.
RITS complex
The hydroxylation of peptidyl-arginine to form peptidyl-hydroxyarginine.
peptidyl-arginine hydroxylation
The transfer of electrons from NADH to the quinone pool that occurs during oxidative phosphorylation and results in the generation of a proton gradient, mediated by the enzyme known as NADH-quinone oxidoreductase.
plasma membrane electron transport, NADH to quinone
Binding to taurine.
taurine binding
Binding to a high molecular weight kininogen receptor.
high molecular weight kininogen receptor binding
A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins.
high molecular weight kininogen receptor complex
A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme.
axonemal heterotrimeric kinesin-II complex
A proteinaceous scaffold associated with fission yeast chromosomes during meiotic prophase. Linear elements consist of a protein complex, LinE, with four main structural components (Rec10, Rec25, Rec27, and Mug20 in S. pombe) associated with chromatin. The resulting structure is related to but not equivalent to the synaptonemal complex.
linear element
A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together.
actin tubule
Binding to troponin I, the inhibitory subunit of the troponin complex.
troponin I binding
Binding to troponin T, the tropomyosin-binding subunit of the troponin complex.
troponin T binding
The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells.
exocrine pancreas development
A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell's complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell.
macronucleus
A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell.
micronucleus
The process in which the anatomical structures of the hair follicle are generated and organized.
hair follicle morphogenesis
Catalysis of the reaction: cholesterol + H+ = + NADPH + O2 = 26-hydroxycholesterol + H2O + NADP+.
cholesterol 26-hydroxylase activity
A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins.
BLOC-1 complex
A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru.
BLOC-2 complex
A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins.
BLOC-3 complex
The lipid bilayer surrounding the platelet dense granule.
platelet dense granule membrane
The volume enclosed by the membrane of the platelet dense granule.
platelet dense granule lumen
The lipid bilayer surrounding the platelet dense tubular network.
platelet dense tubular network membrane
The volume enclosed by the membranes of the platelet dense tubular network.
platelet dense tubular network lumen
The regrowth of fin tissue following its loss or destruction.
fin regeneration
The regrowth of dendrites in response to their loss or damage.
dendrite regeneration
The controlled breakdown of a septin ring.
septin ring disassembly
Any process that modulates the rate, direction or extent of axon growth such that the correct diameter is attained and maintained.
regulation of axon diameter
The process in which a cell initiates conjugation with cellular fusion upon carbon starvation.
induction of conjugation upon carbon starvation
The formation and growth of otoliths throughout the life of the organism. Otoliths are the large extracellular ear-stones of the fish inner ear, produced by precipitation of specific crystal forms of calcium carbonate on organic matrices. The otolith enlarges throughout the life of the fish, as layers of calcium carbonate are added.
lifelong otolith mineralization
Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate).
phosphopantetheine binding
Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline.
phosphatidylcholine binding
A complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue.
endoplasmic reticulum palmitoyltransferase complex
Catalysis of the reaction: alpha-maltotetraose + phosphate = alpha-D-glucose 1-phosphate + alpha-maltotriose.
maltodextrin phosphorylase activity
Binding to a denatured protein.
denatured protein binding
An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit.
anaerobic ribonucleoside-triphosphate reductase complex
The area of a motile cell perpendicular to the direction of movement.
lateral part of motile cell
The portion of the plasma membrane surrounding a lamellipodium.
lamellipodium membrane
The portion of the plasma membrane surrounding a pseudopodium.
pseudopodium membrane
Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage.
alpha-1,2-galactosyltransferase activity
An intracellular signaling cassette in which a small monomeric GTPase of the Ran subfamily relays a signal.
Ran protein signal transduction
The removal of an amino group from the side chain of an N-terminal asparagine or glutamine residue of a protein.
N-terminal protein amino acid deamination, from side chain
A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus.
viral RNA-directed RNA polymerase complex
Any process that modulates the frequency, rate, or extent of the start of mating projection formation by unicellular fungi.
regulation of initiation of mating projection growth
Any process that modulates the frequency, rate, or extent of the end of mating projection formation by unicellular fungi.
regulation of termination of mating projection growth
A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13. The MPF complex phosphorylates and activates the anaphase promoting complex (APC).
MPF complex
The process of introducing one or more phosphate groups into an organic acid.
organic acid phosphorylation
A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits.
bursicon neuropeptide hormone complex
Binding to lipoic acid, 1,2-dithiolane-3-pentanoic acid.
lipoic acid binding
A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts.
invertasome
Binding to a hexon, the major protein component of the icosahedral capsid of an adenovirus.
hexon binding
Binding to titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.
titin binding