NothingMuch/GO-Terms huggingface dataset:
Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+.
11-beta-hydroxysteroid dehydrogenase (NAD+) activity
Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein.
K63-linked polyubiquitin modification-dependent protein binding
A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites.
BRCA1-A complex
A protein complex that contains the BRCA1-BARD1 heterodimer, BACH1 and TopBP1, and binds to DNA during S phase at DNA damage sites.
BRCA1-B complex
A protein complex that contains the BRCA1-BARD1 heterodimer, CtIP and Mre11/Rad50/NBS1 (M/R/N) complex, and binds to DNA at DNA damage sites. BRCA1-C binding ta damaged DNA is required for DNA damage-induced Chk1 phosphorylation and the G2/M transition checkpoint.
BRCA1-C complex
Binding to oleic acid, the 18-carbon monounsaturated fatty acid (9Z)-octadec-9-enoic acid.
oleic acid binding
Binding to linoleic acid, the 18-carbon unsaturated fatty acid (9Z,12Z)-octadeca-9,12-dienoic acid.
linoleic acid binding
Binding to stearic acid, the 18-carbon saturated fatty acid octadecanoic acid.
stearic acid binding
A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively.
PeBoW complex
A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains.
BRISC complex
A protein complex that contains the cyclin-dependent protein kinase inhibitor p21WAF1/CIP1 bound to PCNA; formation of the complex inhibits DNA replication.
PCNA-p21 complex
The regulated release of proteins by a platelet or group of platelets.
protein secretion by platelet
A complex of DNA and protein located at the end of a linear chromosome that enables replication of the telomeric repeat sequences at the end of a linear chromosome.
telomere-telomerase complex
The directed movement of tungstate (WO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tungstate is a bivalent oxoanion of tungsten.
tungstate ion transport
A protein complex that contains the epidermal growth factor receptor (EGFR), Grb2, the adaptor protein SHC and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.
EGFR-Shc-Grb2-Sos complex
The release of intracellular molecules contained within the zymogen granule by fusion of the granule with the plasma membrane of the oocyte, requiring calcium ions.
zymogen granule exocytosis
Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation.
proteasome binding
The directed movement of ammonium ions from one side of an epithelium to the other.
transepithelial ammonium transport
An actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. In fungal cells, myosin motors transport cargo along actin cables toward sites of polarized cell growth; actin cables may play a similar role in pollen tube growth.
formin-nucleated actin cable
Differentiation of new neuromast sensory hair cells to replace those lost or destroyed by injury.
neuromast hair cell differentiation involved in neuromast regeneration
Differentiation of new inner ear sensory hair cells to replace those lost or destroyed by injury.
inner ear receptor cell differentiation involved in inner ear sensory epithelium regeneration
Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylcytosine.
rRNA (cytosine-2'-O-)-methyltransferase activity
A tRNA aminoacylation process in which asparaginyl-tRNAAsn is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating aspartyl-tRNA synthetase generates the misacylated L-aspartyl-tRNAAsn species, and in the second step it is amidated to the correctly charged L-asparaginyl-tRNAAsn by the heterotrimeric aspartyl-tRNAAsn amidotransferase.
asparaginyl-tRNAAsn biosynthesis via transamidation
A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase.
glutaminyl-tRNAGln biosynthesis via transamidation
A protein complex that is composed of AKTIP/FTS, FAM160A2/p107FHIP, and one or more members of the Hook family of proteins, HOOK1, HOOK2, and HOOK3. The complex is thought to promote vesicle trafficking and/or fusion, and associates with the homotypic vesicular sorting complex (the HOPS complex).
FHF complex
Binding to a type I activin receptor.
type I activin receptor binding
Binding to a type II activin receptor.
type II activin receptor binding
The inner of two mucus layers secreted by epithelial cells in the colon; the inner mucus layer is firmly attached to the epithelium, is densely packed with a compact stratified appearance and is devoid of bacteria.
inner mucus layer
The outer of two mucus layers secreted by epithelial cells in the colon; the outer mucus layer is loosely packed and can be colonized by bacteria.
outer mucus layer
The directed, sodium-dependent, movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
sodium-dependent organic cation transport
A cytoplasmic part that appears as an electron-dense sphere of around 1.5 micron diameter containing Yb protein found in somatic cells of ovary and testis. There are one to two Yb bodies per cell.
Yb body
An organelle envelope that surrounds the chromosomes and the central part of the spindle apparatus during mitosis and meiosis; observed in many invertebrates. The spindle envelope consists of membrane layers, called parafusorial membranes, derived from endoplasmic reticulum membrane; in male meiosis it forms during prometaphase and persists until early in the ensuing interphase.
spindle envelope
Binding to a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion.
C2H2 zinc finger domain binding
A protein complex that is formed by the association of the Notch ligand Delta1 with the gamma-secretase complex.
gamma-secretase-Delta1 complex
A protein complex that contains BRCA1 and Rad 51, and is involved in the control of recombination and of genome integrity.
BRCA1-Rad51 complex
A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.
MOZ/MORF histone acetyltransferase complex
Any process that stops, prevents, or reduces the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella.
negative regulation of cleistothecium development
Any process that activates or increases the frequency, rate or extent of cleistothecium development, a process that leads to the formation of a cleistothecium. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella.
positive regulation of cleistothecium development
Any process that stops, prevents, or reduces the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop.
negative regulation of conidiophore stalk development
Any process that activates or increases the frequency, rate or extent of conidiophore stalk development, a process that leads to the formation of a conidiophore stalk. The conidiophore stalk is part of a specialized hypha that extends aerially from the growth substrate and supports structures from which conidia, or asexual spores, develop.
positive regulation of conidiophore stalk development
Any process that stops, prevents, or reduces the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip.
negative regulation of metula development
Any process that activates or increases the frequency, rate or extent of metula development, a process that leads to the formation of metulae. Metulae are elongated mononucleate cells that bud from the surface of the conidiophore tip.
positive regulation of metula development
Any process that stops, prevents, or reduces the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip.
negative regulation of phialide development
Any process that activates or increases the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip.
positive regulation of phialide development
Any process that stops, prevents, or reduces the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body.
negative regulation of Hulle cell development
Any process that activates or increases the frequency, rate or extent of Hulle cell development, a process that leads to the formation of Hulle cells. Hulle cells are specialized multinucleate cells that originate from a nest-like aggregation of hyphae during sexual development and serve as nurse cells to the developing cleistothecium, or fruiting body.
positive regulation of Hulle cell development
The lipid bilayer surrounding a tertiary granule.
tertiary granule membrane
A tetrameric histone deacetylase complex that contains a Class II deacetylase catalytic subunit. In S. cerevisiae it is composed of two Hda1p subunits along with Hda2p and Hda3p.
HDA1 complex
A single cone-shaped specialization that forms an opening in the egg chorion that allows sperm entry into the egg prior to fertilization.
chrorion micropyle
A cytoplasmic protein complex that contains integrin, mobilferrin and a flavin monooxygenase, is capable of reducing Fe(III) to Fe(II) utilizing NADPH, and is involved in iron transport. Fe(II) is required in the cell as the substrate for ferrochelatase in the synthesis of heme.
paraferritin complex
The phosphatidylcholine biosynthetic process that begins with three consecutive N-methylation steps that are carried out on phospho-bases, phosphoethanolamine, phospho-N-methylethanolamine, and phospho-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine.
phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline
The phosphatidylcholine biosynthetic process that begins with an initial N-methylation with phospho-base phosphoethanolamine, followed by two downstream N-methylations on phosphatidyl-bases, phosphatidyl-N-methylethanolamine and phosphatidyl-N-dimethylethanolamine. The process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine.
phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via CDP-N-methylethanolamine
The phosphatidylcholine biosynthetic process that begins with two N-methylations with phospho-base phosphoethanolamine and phospho-N-methylethanolamine, followed by a downstream N-methylation on phosphatidyl-base phosphatidyl-N-dimethylethanolamine; the process ends with the conversion of a phosphatidyl-N-dimethylethanolamine to a phosphatidylcholine.
phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine
Enables the transfer of chromium (Cr) ions from one side of a membrane to the other.
chromium ion transmembrane transporter activity
The aggregation, arrangement and bonding together of a set of components to form an aggresome; requires the microtubule cytoskeleton and dynein.
aggresome assembly
The modification of an Hsp90 protein by removal of acetyl groups.
Hsp90 deacetylation
A protein complex that contains the transforming acidic coiled coil (TACC) protein and the TOG protein (Mia1p/Alp7p and Alp14, respectively, in fission yeast), and is involved in microtubule array remodeling as cells progress through the cell cycle. The TACC/TOG complex is conserved in eukaryotes, associates with microtubules, and shuttles between the nucleus and the cytoplasm during interphase.
TACC/TOG complex
Binding to the head/neck region of a myosin VI heavy chain.
myosin VI head/neck binding
Binding to a light chain of a myosin VI complex.
myosin VI light chain binding
A RNA polymerase I-specific transcription factor complex that is required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrn6p, Rrn7p, and Rrn11p.
RNA polymerase I core factor complex
Binding to a protein or protein complex in the presence of sterols.
sterol-dependent protein binding
A protein complex that functions downstream of the MRN complex to promote DNA repair and the G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and is composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80.
SOSS complex
A protein complex that binds to heme and to pri-miRNAs, and is required for the formation of a pre-microRNA (pre-miRNA), the initial step of microRNA (miRNA) biogenesis. The complex is composed of the double-stranded-RNA-specific RNase Drosha (also called RNASEN) and the RNA-binding protein DGCR8 (heme-free or heme-bound forms). Within the complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs RNASEN/Drosha to cleave the 3' and 5' strands of a stem-loop to release hairpin-shaped pre-miRNAs.
microprocessor complex
Binding to lipoteichoic acid.
lipoteichoic acid binding
The posttranscriptional addition of methyl groups to specific residues in a mitochondrial tRNA molecule.
mitochondrial tRNA methylation
The intramolecular conversion of uridine to pseudouridine in a mitochondrial tRNA molecule.
mitochondrial tRNA pseudouridine synthesis
A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Ckn1 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases.
Ddb1-Ckn1 complex
A heterodimeric nucleotide-excision repair complex that is involved in transcription-coupled repair. The subunits are known as Ddb1 and Wdr21 in S. pombe; Ddb1 contains a motif called the DDB-box that interacts with adaptor proteins for DDB1/cullin 4 ubiquitin ligases.
Ddb1-Wdr21 complex
Any process that modulates the activity of an ATP:ADP antiporter.
regulation of ATP:ADP antiporter activity
A translational elongation process in which transfer of a translating ribosome from one mRNA to another RNA template takes place. Trans-translation occurs during tmRNA release of stalled ribosomes.
trans-translation
The volume enclosed by the membrane of a Golgi-associated vesicle.
Golgi-associated vesicle lumen
The aggregation, arrangement and bonding together of a set of components to form an eisosome, a cell part that is composed of the eisosome membrane and eisosome filaments. The eisosome membrane, also called the MCC domain, is a furrow-like plasma membrane sub-domain with associated integral transmembrane proteins. The eisosome filaments form a scaffolding lattice on the cytoplasmic face of the membrane.
eisosome assembly
Binding to F420, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
coenzyme F420 binding
Binding to a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors.
POU domain binding
Cellular protein complex assembly that results in the formation of a voltage-gated calcium channel complex.
voltage-gated calcium channel complex assembly
A protein ubiquitination process in which ubiquitin monomers are attached to a protein, and then ubiquitin polymers are formed by linkages between lysine residues at position 11 of the ubiquitin monomers. K11-linked polyubiquitination targets the substrate protein for degradation. The anaphase-promoting complex promotes the degradation of mitotic regulators by assembling K11-linked polyubiquitin chains.
protein K11-linked ubiquitination
The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions but does not causes an increase in the endogenous mutation level. For S. cerevisiae, RAD30 encodes DNA polymerase eta, which incorporates two adenines. When incorporated across a thymine-thymine dimer, it does not increase the endogenous mutation level.
error-free translesion synthesis
The series of events in which a stimulus indicating oxidative stress is received and converted into a molecular signal.
detection of oxidative stress
The series of events involved in the perception of gravity in which a sensory mechanical stimulus is received and converted into a molecular signal.
detection of mechanical stimulus involved in sensory perception of gravity
A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4 and U6, a heptameric ring of Sm proteins associated with U4, the Lsm2-8 heptameric ring complex associated with U6, as well as several proteins that are unique to the U4 snRNP or U6 snRNPs, some of which remain associated with the U4/U6 snRNA both while the U4 snRNP is free or assembled into a series of spliceosomal complexes.
U4/U6 snRNP
A ribonucleoprotein complex that contains the extensively base paired small nuclear RNAs U4atac and U6atac, a heptameric ring of Sm proteins associated with U4atac, the Lsm2-8 heptameric ring complex associated with U6atac, as well as several proteins that are unique to the U4atac snRNP or U6atac snRNPs, some of which remain associated with the U4atac/U6atac snRNA both while the U4atac snRNP is free or assembled into a series of spliceosomal complexes.
U4atac/U6atac snRNP
A spliceosomal complex that forms during the addition of a specific spliced leader (SL) sequence to the 5'-end of a messenger RNA primary transcript, a process which occurs in a number of eukaryotic organisms, including trypanosomatid protozoans, euglenoids, nematodes, trematodes, and chordates.
trans spliceosomal complex
A ribonucleoprotein complex that contains spliced leader (SL) RNA and associated proteins.
SL snRNP
A nuclear tRNA surveillance pathway, dependent on the TRAMP exosome adaptor and the nuclear exosome.
TRAMP-dependent tRNA surveillance pathway
The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA) within the nucleus.
nuclear histone mRNA catabolic process
Binding to eukaryotic initiation factor eIF2, a protein complex involved in the initiation of ribosome-mediated translation.
eukaryotic initiation factor eIF2 binding
A protein complex that contains the eukaryotic translation initiation factor 2 complex (EIF2), CUG binding protein 1, and several endoplasmic reticulum proteins; the complex is involved in the regulation of translation.
CUGBP1-eIF2 complex
The enzymatic addition of a sequence of uridylyl residues at the 3' end of an RNA molecule.
RNA 3' uridylation
The process whose specific outcome is the progression of the superior temporal gyrus over time, from its formation to the mature structure. The superior temporal gyrus is a portion of the cerebral cortex that extends from the lateral sulcus to the superior temporal sulcus.
superior temporal gyrus development
The cleavage and rejoining of intermediates, mitotic recombination to produce two intact molecules in which genetic material has been exchanged.
resolution of mitotic recombination intermediates
Catalysis of the reaction: ATP + n + L-Asp = ADP + phosphate + n-L-Asp.
cyanophycin synthetase activity (L-aspartate-adding)
Catalysis of the reaction: ATP + n-L-Asp + L-arginine = ADP + phosphate + n+1.
cyanophycin synthetase activity (L-arginine-adding)
The aggregation, arrangement and bonding together of a set of components to form a GINS complex, a heterotetrameric protein complex that associates with DNA replication origins and replication forks.
GINS complex assembly
A DNA replication termination process that takes place at the RTS1 termination site in the mating type locus, in a specific direction required for subsequent imprinting and mating-type switching.
site-specific DNA replication termination at RTS1 barrier
Catalysis of the reaction: 7,8-dihydromonapterin + NADPH = tetrahydromonapterin + NADP+.
dihydromonapterin reductase activity
A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.2.
Kv4.2-KChIP1 channel complex
A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP2 associated with the channel via interaction with the Kv alpha subunit 4.2.
Kv4.2-KChIP2 channel complex
A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP3 associated with the channel via interaction with the Kv alpha subunit 4.2.
Kv4.2-KChIP3 channel complex
A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP4 associated with the channel via interaction with the Kv alpha subunit 4.2.
Kv4.2-KChIP4 channel complex
A voltage-gated potassium channel complex that contains the Kv channel interacting protein KChIP1 associated with the channel via interaction with the Kv alpha subunit 4.3.
Kv4.3-KChIP1 channel complex
A voltage-gated potassium channel complex that contains the Kv alpha subunits 4.2 and 4.3.
Kv4.2-Kv4.3 channel complex
A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53.
WASH complex
Binding to a conserved stem-loop structure found in histone pre-mRNAs.
histone pre-mRNA stem-loop binding
Binding to the downstream cleavage product (DCP) generated by histone pre-mRNA 3'-end processing.
histone pre-mRNA DCP binding
Binding to a U7 small nuclear RNA (U7 snRNA).
U7 snRNA binding
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus.
cellular response to 1-aminocyclopropane-1-carboxylic acid