NothingMuch/GO-Terms huggingface dataset:
The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase.
negative regulation of protein kinase activity by regulation of protein phosphorylation
A dynamic, actin-rich projection extending from the surface of a migrating animal cell.
microspike
The modification of a protein amino acid by the addition of a malonyl (CO-CH2-CO) group.
protein malonylation
Combining with glucagon-like peptide 1 and transmitting the signal across the membrane by activating an associated G-protein.
glucagon-like peptide 1 receptor activity
The modification of a peptidyl-cystine residue in a protein by the addition of sulfur, to form peptidyl-cysteine persulfide.
peptidyl-cystine sulfhydration
Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs.
regulation of mitochondrial mRNA stability
Any process that modulates the propensity of mitochondrial rRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial rRNAs.
regulation of mitochondrial rRNA stability
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures of a host cell.
host cell periphery
Catalysis of the reaction: L-cystine + H2O = pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide.
L-cystine L-cysteine-lyase (deaminating)
The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.
dendritic cell proliferation
A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage.
chondrocyte activation
Binding to cellotriose.
cellotriose binding
Binding to a cellodextrin, a glucose polymer of 2 or more glucose monomers.
cellodextrin binding
Binding to cellobiose, a disaccharide that represents the basic repeating unit of cellulose.
cellobiose binding
Binding to a cellotetraose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose.
cellotetraose binding
Binding to a cellopentaose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose.
cellopentaose binding
Binding to laminaribiose, a disaccharide.
laminaribiose binding
Binding to pectin.
pectin binding
Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+.
17-beta-hydroxysteroid dehydrogenase (NAD+) activity
The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy.
doxorubicin metabolic process
Catalysis of the reaction: GTP + protein = diphosphate + guanylyl-protein; mediates the addition of an guanylyl (guanosine 5'-monophosphate; GMP group) to specific residues of target proteins.
protein guanylyltransferase activity
Catalysis of the reaction: CDP-choline + protein-serine = CMP + protein-serine-choline phosphate.
phosphocholine transferase activity
Catalysis of the reaction: protein-serine-choline phosphate + H2O = protein-serine + choline phosphate.
phosphocholine hydrolase activity
A protein complex that associates with mRNP particles and RNA polymerase II and is proposed to integrate transcript elongation with the regulation of alternative splicing. In humans it is composed of the proteins KIAA1967/DBC1 and ZNF326/ZIRD.
DBIRD complex
A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component.
nuclear pore nuclear basket
The attachment of a symbiont to a host epithelial cell via adhesion molecules, general stickiness etc., either directly or indirectly.
adhesion of symbiont to host epithelial cell
The attachment of a symbiont to a host endothelial cell via adhesion molecules, general stickiness etc., either directly or indirectly.
adhesion of symbiont to host endothelial cell
A cellular process of the specification, formation or maintenance of an alternative cell type, occurring as part of the process of phenotypic switching. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns.
establishment or maintenance of cell type involved in phenotypic switching
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ malonate(out) = sodium(in) + malonate(in).
sodium:malonate symporter activity
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ galactoside(out) = sodium(in) + galactoside(in).
sodium:galactoside symporter activity
A hexameric complex consisting of three polypeptides in an alpha2beta2gamma2 arrangement. Involved in the reduction of the coenzyme M-bound methyl group to methane, which is the final step in methanogenesis.
methyl coenzyme M reductase complex
A protein complex consisting of four polypeptides which also contains tungsten, a molybdopterin guanine dinucleotide, and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis.
formyl-methanofuran dehydrogenase (tungsten enzyme) complex
A protein complex consisting of three polypeptides which also contains molybdenum, a molybdopterin guanine dinucleotide and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis.
formyl-methanofuran dehydrogenase (molybdenum enzyme) complex
A protein complex which catalyzes the conversion of methanophenazine and hydrogen to form dihydromethanophenazine. This typically consists of three polypeptides.
methanophenazine reducing hydrogenase complex
A complex of two polypeptides which form a dodecamer (A6B6). Catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde. This reaction is involved in coenzyme M biosynthesis.
sulfopyruvate decarboxylase complex
Catalysis of the reaction: 7,8-dihydromethanopterin + NADPH = 5,6,7,8-tetrahydromethanopterin + NADP.
dihydromethanopterin reductase activity
Catalysis of the reaction: O-phospho-L-serine + sulfite + H+ = L-cysteate + phosphate.
cysteate synthase activity
Catalysis of the reaction: (2E,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate.
geranylfarnesyl diphosphate synthase activity
Catalysis of the reaction: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H+.
7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity
The tooth development process in which the teeth enter the mouth and become visible.
tooth eruption
Binds to and increases the activity of an exoribonuclease.
exoribonuclease activator activity
An E3 ubiquitin ligase complex localized to the ER and Golgi membrane. In fission yeast comprises Dsc1, 2, 3 and 4. Involved in the processes of fission yeast sre1 (human SREBP) transcriptional activator proteolytic cleavage, the multivesicular body (MVB) pathway, and a post-endoplasmic reticulum pathway for protein catabolism.
Dsc E3 ubiquitin ligase complex
A multisubunit complex involved in cytokinesis. In the yeast Saccharomyces cerevisiae this complex consists of Sho1p, Hof1p, Inn1p and Cyk3p proteins.
HICS complex
Catalysis of the reaction 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate.
8-oxo-dGDP phosphatase activity
Catalysis of the reaction 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate.
8-oxo-GDP phosphatase activity
Catalysis of the reaction: 8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate.
8-hydroxy-dADP phosphatase activity
Any process that reduces the size of an imaginal disc-derived wing.
negative regulation of imaginal disc-derived wing size
The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane.
protein import into peroxisome matrix, substrate release
Catalysis of the high-affinity transfer of nickel (Ni) cations from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.
high-affinity nickel cation transmembrane transporter activity
A subcomplex of the DNA polymerase III holoenzyme which is responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. The complex is homodimeric in prokaryotes, and homotrimeric in other species.
DNA polymerase III, beta sliding clamp processivity factor complex
The directed movement of substances, in membrane-bounded vesicles, from the trans-Golgi network to the recycling endosomes.
trans-Golgi network to recycling endosome transport
The glycolytic fermentation beginning with the anaerobic conversion of glucose to pyruvate by the glycolytic pathway, continuing with pyruvate:ferredoxin oxidoreductase (PFOR) activity. This pathway is found in strict anaerobes such as Clostridia species.
glycolytic fermentation via PFOR pathway
The glycolytic fermentation beginning with the anaerobic conversion of glucose to pyruvate by the glycolytic pathway, followed by pyruvate:formate lyase (PFL) activity. This pathway is found in facultative anaerobes such as E. coli.
glycolytic fermentation via PFL pathway
A dimer of Nsk1 (nucleolus spindle kinetochore 1) and the dynein light chain, Dlc1. The dimers form an oligomeric chain structure. Functions in the regulation of kinetochore-microtubule interactions and chromosome segregation.
Nsk1-Dlc1 complex
A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral genome replication.
negative regulation by host of viral genome replication
A process in which a host organism activates or increases the frequency, rate or extent of viral genome replication.
positive regulation by host of viral genome replication
Any viral process that modulates the frequency, rate or extent of protein transport in its host organism.
modulation by virus of host protein transport
A tetramer of retroviral integrase subunits tightly associated with a pair of viral DNA ends. Functions to insert viral DNA into a host cell chromosome.
retroviral intasome
The chemical reactions and pathways resulting in the formation of H2 (dihydrogen) which involve a nitrogenase activity as one of the steps. This process is observed in cyanobacteria.
hydrogen generation via nitrogenase
The membrane of a gut granule, a lysosome-related organelle contained within the intestinal cells of the nematode C. elegans.
gut granule membrane
The lumen of a gut granule, a lysosome-related organelle contained within the intestinal cells of the nematode C. elegans.
gut granule lumen
The cell cycle phase which begins at the end of meiosis I cytokinesis and ends when meiosis II prophase begins. During meiotic interphase II no DNA replication takes place, but the centrioles duplicate and spindle fibres emerge.
meiotic interphase II
Extension of the O-linked mannose residue of a mannoprotein by the stepwise addition of further mannose molecules.
chain elongation of O-linked mannose residue
A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur.
estrous cycle
A type of ovulation cycle where the endometrium is shed if pregnancy does not occur.
menstrual cycle
The process in which a protein is incorporated into a plasma membrane raft.
protein insertion into plasma membrane raft
The directed movement of a protein into a plasma membrane raft.
protein transport into plasma membrane raft
The directed movement of a protein out of a plasma membrane raft.
protein transport out of plasma membrane raft
Any process where an infecting virus activates or increases the frequency, rate or extent of its host's cell division.
positive regulation by virus of host cell division
The process in which a host organism decreases viral exo-alpha-sialidase activity, the catalysis of the hydrolysis of peptide bonds in a protein.
negative regulation by host of viral exo-alpha-sialidase activity
A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral glycoprotein metabolic process.
negative regulation by host of viral glycoprotein metabolic process
A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane.
lipoprotein localization to outer membrane
Correction of replication errors by DNA polymerase using a 3'-5' exonuclease activity.
DNA replication proofreading
The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar.
depurination
The disruption of the bond between the sugar in the backbone and the C or T base, causing the base to be removed and leaving a depyrimidinated sugar.
depyrimidination
Binding to DNA ends exposed by the creation of double-strand breaks (DSBs).
DNA end binding
The acquisition of peroxisomes by daughter cells from the mother cell after replication. In Saccharomyces cerevisiae, the number of peroxisomes cells is fairly constant; a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process. Efficient segregation of peroxisomes from mother to bud is dependent on the actin cytoskeleton, and active movement of peroxisomes along actin filaments is driven by the class V myosin motor protein, Myo2p.
peroxisome inheritance
Binding to a pre-mRNA branch point sequence, located upstream of the 3' splice site.
pre-mRNA branch point binding
Binding to a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination.
triplex DNA binding
A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement.
myosin I complex
A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle.
fusome
A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome.
spectrosome
The region that lies just beneath the plasma membrane on the basal edge of a cell.
basal cortex
Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
zonula adherens assembly
The maintenance of the apicobasal polarity of an epithelial cell.
maintenance of epithelial cell apical/basal polarity
Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells.
zonula adherens maintenance
Complex that possesses isocitrate dehydrogenase (NAD+) activity.
isocitrate dehydrogenase complex (NAD+)
A protein complex located in the cytosol containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors.
cytosolic electron transfer flavoprotein complex
A cytosolic complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
cytosol pyruvate dehydrogenase (lipoamide) phosphatase complex
A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR004224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)).
fumarate reductase complex
Binding to catenin complex alpha subunit.
alpha-catenin binding
A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly.
tubulin complex
The growth of colonies in filamentous chains of cells as a result of a pheromone stimulus.
invasive growth in response to pheromone
A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a rhabdomere membrane.
rhabdomere membrane biogenesis
The formation and development of the equator that forms the boundary between the photoreceptors in the dorsal sector of the eye and those in the ventral sector, dividing the eye into dorsal and ventral halves.
equator specification
Binding to uan nmethylated CpG motif. Unmethylated CpG dinucleotides are often associated with gene promoters.
unmethylated CpG binding
Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis.
trichothecene 3-O-acetyltransferase activity
The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium.
R8 cell development
The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
R8 cell fate specification
The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium.
R7 cell development
Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain.
omega-6 fatty acid desaturase activity
Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light.
photoreceptor cell maintenance
The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg.
sex comb development
Binding to a light chain of the dynein complex.
dynein light chain binding
Binding to a heavy chain of the dynein complex.
dynein heavy chain binding
Binding to an intermediate chain of the dynein complex.
dynein intermediate chain binding
Catalysis of the reaction: 2 2-oxoglutarate + gibberellin A12 (GA12) + H+ + 3 O2 = 3 CO2 + gibberellin A9 (GA9) + 2 H2O + 2 succinate. This reaction results in the oxidation of C-20 gibberellins to form the corresponding C-19 lactones, via a three-step oxidation at C-20 of the GA skeleton. Also converts GA53 to GA20. GA25 is also formed as a minor product.
gibberellin 20-oxidase activity
Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells.
syndecan binding
Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate.
dehydrodolichyl diphosphate synthase activity
Catalysis of the formation of phytyl group from the stepwise reduction of a geranylgeranyl group.
geranylgeranyl reductase activity
Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
negative regulation of cyclin-dependent protein serine/threonine kinase activity
Any process that increases cell volume.
positive regulation of cell volume
Any process that increases the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion.
pH elevation
Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells.
lateral inhibition
Catalysis of the reaction: ferulic acid + NADPH + H+ + O2 = 5-hydroxyferulic acid + H2O + NADP+.
ferulate 5-hydroxylase activity
The joining of the parts of the wing imaginal discs, giving rise to the adult thorax.
imaginal disc fusion, thorax closure
Catalysis of the reaction: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate; this reaction does not require the cofactor 2,3-bisphosphoglycerate.
2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion.
development of secondary male sexual characteristics
Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light.
retinal rod cell development
Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision.
retinal cone cell development
Catalysis of the deacetylation of xylans and xylo-oligosaccharides.
acetylxylan esterase activity
Catalysis of the reaction: 3-dehydroshikimate = 3,4-dihydroxybenzoate + H2O. 3,4-dihydroxybenzoate is also known as protocatechuate.
3-dehydroshikimate dehydratase activity
Catalysis of the reaction: versiconal = versicolorin B + H2O.
versicolorin B synthase activity
Catalysis of the removal of acetylesters (as acetate) from galacturonic acid residues in the backbone of rhamnogalacturonan.
rhamnogalacturonan acetylesterase activity
An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates.
intercellular canaliculus
Catalysis of the isomerization of poly-cis-carotenoids to all-trans-carotenoids.
carotenoid isomerase activity
The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo.
dorsal closure, amnioserosa morphology change
Maintenance of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis.
amnioserosa maintenance
The process in which the use of stored sperm from the first-mating male is inhibited by the seminal fluid of subsequently mating males.
sperm incapacitation
Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to a galactoside acceptor molecule, usually an N-glycan, to form an alpha(1,6)-fucosylated galactoside.
galactoside 6-L-fucosyltransferase activity
A stable empty viral capsid produced during the assembly of viruses.
viral procapsid
The process of organizing and assembling viral replication proteins in preparation for viral replication.
viral replication complex formation and maintenance
The process of restoring viral DNA after damage or errors in replication.
viral DNA repair
Binding to a virion, either by binding to components of the capsid or the viral envelope.
virion binding