0
stringlengths
12
494
embeddings
sequencelengths
384
384
chromosome.\tSuch\tsequences\tare\tcalled\t\nintervening\tsequences\n\tand\tcompose\tthe\tmajority\n\tof\tthe\nDNA\tin\thumans.\tThese\tsequences\tdo\tnot\tcode\tfor\tproteins,\tbut\tthey\tare\tnot\t“junk\tDNA”\tas\toriginally\nthought.\tInstead,\tthey\tperform\tstructural\tand\tregulatory\tfunctions,\tsuch\tas\tcontrolling\twhen,\twhere,\nand\thow\tmuch\tof\ta\tprotein\tis\tproduced.
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and\thow\tmuch\tof\ta\tprotein\tis\tproduced.\nThe\tlarge\tamount\tof\tgenetic\tmaterial\tin\tthe\tnucleus\tis\tdistributed\tamong\tmultiple\t\nchromosomes\n,\nwhich\tare\tformed\tby\twrapping\tDNA\ttightly\taround\tspecific\n\tproteins\tcalled\t\nhistones\n.\tHuman\tbeings\nhave\t23\tpairs\tof\tchromosomes,\t22\t\nautosomes\n,\tand\t2\t\nsex\tchromosomes\n.\tOne\tcopy\tof\teach\tmember
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0.013854228891432285, 0.07752401381731033, -0.02530832402408123, 0.06693144887685776, 0.08913395553827286, -0.06655033677816391, -0.026951048523187637, 0.09568100422620773, -0.006732884794473648, -0.04349252209067345, -0.016704585403203964, 0.07927510142326355, -0.017701148986816406, -0.061206649988889694, -0.05687406659126282, 0.028680603951215744, 0.011337804608047009, 0.022013582289218903, -0.01819438301026821, -0.0033470934722572565, 0.05243527144193649, 0.08328192681074142, 0.09597145020961761, -0.02771584875881672 ]
autosomes\n,\tand\t2\t\nsex\tchromosomes\n.\tOne\tcopy\tof\teach\tmember\nof\ta\tpair\tcomes\tfrom\tthe\tmother\tand\tthe\tother\tfrom\tthe\tfather.\tFemales\thave\ttwo\tX\tchromosomes;\nmales\thave\tone\tX\tand\tone\tY\tchromosome.\tThe\tnucleus\tof\teach\thuman\tcell\tcontains\tall\t46\nchromosomes.\nGene\texpression:\tTranscription\tand\ttranslation\nTo\tinitiate\tthe\tprocess
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To\tinitiate\tthe\tprocess\n\tof\tdecoding\tthe\tDNA,\tthe\tcondensed\tchromosomes\thousing\tthe\tgenes\tfirst\nmust\topen\t(decondense)\tto\tallow\taccess\tto\tthe\tinformation\tin\tthe\tDNA\tnucleotide\tsequence.\tA\ncommon\tmechanism\temployed\tis\tthe\tcovalent\tattachment\tof\tacetyl\tgroups\tto\tthe\thistone\tproteins
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associated\twith\tthe\tchromosomes.\tThis\taction\trelaxes\tthe\tDNA\tand\tmakes\tit\taccessible\tto\tthe\nenzymes\tinvolved\tin\t\ntranscription\n\t(the\tdecoding\n\tprocess).\tInformation\tdecoding\tinvolves\ntranscription\tby\tribonucleic\tacid\t(RNA)\tpolymerase\tinto\tpre-messenger\tRNA\t(pre-mRNA)\tand
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subsequent\ttranslation\tof\tmRNA\tinto\tthe\tamino\tacid\tsequence\tof\tthe\tprotein\taccording\tto\ta\tuniversal\ngenetic\tcode.\tThe\tarchitecture\tof\ta\tgene\ttypically\tincludes\ta\tpromoter\tregion,\twhere\tthe\tRNA\npolymerase\tattaches\tand\ta\t\ncoding\tregion\n\t(also\tcalled\ta\t“structural\tregion”)\n\tthat\tcontains\tthe
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0.08527402579784393, -0.00710638053715229, -0.05960839241743088, 0.09945505112409592, 0.0418628491461277, -0.06649994105100632, -0.04006465896964073, 0.07464329898357391, 0.0008388467249460518, -0.07158426195383072, 0.005232548341155052, 0.0841033086180687, -0.026918217539787292, -0.0457560271024704, -0.06004137918353081, 0.044106267392635345, 0.09708161652088165, 0.046038560569286346, -0.034129418432712555, -0.023066934198141098, 0.06591369956731796, 0.0642494261264801, 0.11083821207284927, -0.04518619552254677 ]
coding\tregion\n\t(also\tcalled\ta\t“structural\tregion”)\n\tthat\tcontains\tthe\nencoded\tinformation\tfor\tsynthesizing\tthat\tgene’s\tprotein.\tWithin\tthe\tcoding\tregion\tare\tsequences\tof\nnucleotides\tcalled\t\nexons\n\tthat\tcorrespond\tto\tthe\torder\tof\tthe\tamino\tacids\tin\tthe\tgene’s\tprotein\nproduct.\tThe\tcoding\tregion\talso\tcontains\t\nintrons
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-0.09909909218549728, -0.03830626234412193, -0.052478861063718796, 0.00267866556532681, 0.07901161164045334, -0.0236972626298666, -0.041059110313653946, -0.05068400874733925, 0.027681544423103333, 0.005234960000962019, -0.02797210030257702, -0.07360690087080002, -0.05524026229977608, 0.007148121017962694, 0.017271140590310097, -0.04252975434064865, 0.06723697483539581, 0.005628117360174656, 0.07606642693281174, -0.05648384988307953, -0.08416222035884857, 0.03796694427728653, -0.0025623950641602278, -0.05719539523124695, 0.006232035346329212, 0.0662345439195633, -0.077949158847332, -0.0858192890882492, 0.05529199540615082, -0.04619849845767021, -0.028461618348956108, -0.03567708283662796, -0.027976838871836662, -0.015713118016719818, -0.004404907580465078, -0.021631089970469475, -0.018636910244822502, 0.036163706332445145, 0.030983062461018562, 0.0007115649059414864, 0.018136557191610336, 0.05511888489127159, -0.004276541527360678, 0.04804999753832817, -0.010087480768561363, 0.1190195307135582, 0.07281940430402756, 0.11295652389526367, 0.09532987326383591, -4.420458665777005e-8, 0.014879797585308552, -0.07425323128700256, 0.005637339316308498, -0.035962339490652084, 0.11591249704360962, 0.010339354164898396, 0.03644796460866928, -0.043664660304784775, -0.029091322794556618, -0.07230580598115921, 0.028249187394976616, 0.06965649127960205, -0.10698263347148895, -0.017722267657518387, 0.08836007863283157, 0.03507235646247864, -0.024599488824605942, 0.005969328805804253, -0.011383842676877975, -0.01399711798876524, 0.03149932622909546, 0.1240902841091156, -0.06601246446371078, -0.01769023761153221, -0.05901959910988808, 0.011587356217205524, -0.006653959862887859, 0.019949810579419136, -0.007910476066172123, 0.01554757822304964, 0.05713973194360733, -0.023909684270620346, -0.03252815827727318, -0.027705145999789238, -0.0077388896606862545, 0.02115771174430847, -0.046114616096019745, -0.08067640662193298, -0.017908601090312004, 0.04202432185411453, 0.08670265227556229, -0.00013814278645440936, -0.09361673891544342, 0.07232023775577545, 0.04741653800010681, -0.050589680671691895, 0.0009577074088156223, 0.0723487138748169, -0.018641190603375435, -0.03399517759680748, 0.023306794464588165, 0.05214539170265198, -0.03521104156970978, -0.06082974001765251, -0.06061302125453949, 0.017053768038749695, 0.05254290997982025, 0.031092660501599312, -0.022452885285019875, -0.025834577158093452, 0.016484549269080162, 0.08619401603937149, 0.11842288076877594, -0.03453285992145538 ]
product.\tThe\tcoding\tregion\talso\tcontains\t\nintrons\n\t(sequences\tthat\tare\tinterspersed\tbetween\texons\nand\tdo\tnot\tcode\tfor\tamino\tacids\tneeded\tfor\tsynthesizing\tproteins).\nUpstream\tfrom\tthe\tpromoter\n\tregion\tis\tthe\t\nregulatory\tregion\n\tthat\tcontrols\tthe\tability\tof\tthe
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0.0843721479177475, 0.006463865749537945, -0.08498097956180573, 0.07941354811191559, 0.02016415446996689, -0.04765307530760765, -0.03811727836728096, 0.029981112107634544, -0.006354167126119137, -0.029626881703734398, 0.02701425924897194, 0.06955472379922867, -0.00458823936060071, -0.08203399181365967, -0.0501442588865757, 0.02829674258828163, 0.06320027261972427, -0.004576278850436211, -0.016704780980944633, -0.004762633703649044, 0.019871467724442482, 0.04678503796458244, 0.13462291657924652, 0.005547267850488424 ]
region\tis\tthe\t\nregulatory\tregion\n\tthat\tcontrols\tthe\tability\tof\tthe\npolymerase\tto\tattach\tto\tthe\tpromoter,\tthereby\tinfluencing\twhether\ttranscription\toccurs.\tWithin\tthis\nregion\tare\t\nresponse\telements\n,\tDNA\tsequences\tthat\tserve\tas\tbinding\tsites\tfor\tregulatory\tproteins\nsuch\tas\t\ntranscription\tfactors\n\tand\ttheir\tbound\t\nligands
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0.02064661867916584, -0.07208596169948578, 0.036009956151247025, -0.061955131590366364, -0.010235173627734184, 0.005008141975849867, 0.041279248893260956, 0.02280866540968418, -0.027101656422019005, 0.05488380044698715, -0.00042012211633846164, -0.009630199521780014, -0.1310943067073822, -0.04689839109778404, -0.01231309212744236, 0.04100756347179413, 0.04982125386595726, -0.007359751500189304, 0.03254847973585129, -0.030404195189476013, -0.03923378884792328, -0.11106466501951218, 0.0403878316283226, 0.026429250836372375, 0.021759813651442528, -0.005345371086150408, 0.017976948991417885, 0.05159270390868187, 0.06393912434577942, 0.028497867286205292, -0.014604532159864902, -0.000770932121668011, 0.06989661604166031, -0.017068451270461082, 0.04126448184251785, 0.05590088665485382, 0.006165127269923687, -0.052559927105903625, -0.04086317867040634, 0.06723622232675552, 0.015204330906271935, 0.06909152865409851, 0.028046835213899612, -0.01893860474228859, -0.026658985763788223, -0.16158057749271393, -0.10048594325780869, -0.05132303759455681, 0.016804473474621773, 0.09349518269300461, 0.03070865198969841, -0.006025497801601887, -0.04063781350851059, 0.0063280221074819565, -0.037180837243795395, -0.018082642927765846, -0.04196719080209732, -0.03697691857814789, 0.0009137574234046042, 0.02276267297565937, -0.009687722660601139, 0.05663367733359337, -0.005854325834661722, 0.057888664305210114, -0.033079154789447784, -0.08109176158905029, -0.010169435292482376, 0.02724587544798851, -0.06782177090644836, 0.06419452279806137, 0.0038067451678216457, -0.0977502092719078, -0.11911392956972122, 0.041859615594148636, -0.04278901591897011, 0.040738485753536224, -0.034475527703762054, -0.055446919053792953, -0.010975657030940056, 0.007244488690048456, 0.03531710058450699, -0.0027980876620858908, -0.02352782152593136, 0.007002618163824081, -0.03327704593539238, -0.03414583578705788, 0.05964680388569832, 0.06944547593593597, 0.07631261646747589, -0.024799037724733353, 0.0844084620475769, -0.025294430553913116, 0.09716556966304779, 0.06519848853349686, -4.9812179270247725e-8, -0.05374709144234657, -0.019481640309095383, 0.029025260359048843, 0.0015300671802833676, 0.07192029058933258, -0.00010735828254837543, 0.07504023611545563, 0.021072324365377426, -0.01725347526371479, -0.06977969408035278, 0.06869838386774063, 0.045094989240169525, -0.0964241549372673, -0.006626757327467203, 0.11666275560855865, 0.03885349631309509, -0.055447377264499664, 0.023884857073426247, -0.014029336161911488, -0.011030102148652077, 0.003305446822196245, 0.09444646537303925, -0.08115527033805847, 0.032854244112968445, -0.05056736618280411, 0.017089566215872765, -0.04298403859138489, -0.011353126727044582, 0.009620977565646172, 0.03522402420639992, 0.056090086698532104, -0.019295185804367065, -0.05728244036436081, -0.03693290427327156, -0.0859467014670372, 0.05186174437403679, -0.022063162177801132, -0.07553555816411972, -0.020851455628871918, 0.10426094383001328, 0.07018031179904938, 0.01794724352657795, -0.03027655929327011, 0.04872064292430878, 0.05496802181005478, -0.04974370822310448, -0.013227622956037521, 0.05806509777903557, -0.013075584545731544, -0.06148064509034157, 0.013785894960165024, 0.1255325973033905, -0.027683235704898834, -0.010683102533221245, -0.03361067175865173, 0.0062634595669806, 0.07015194743871689, 0.05098799243569374, -0.023480631411075592, 0.021702595055103302, 0.027989881113171577, 0.08394001424312592, 0.08723749965429306, -0.07731708884239197 ]
protein\tproduct\tis\tneeded.\nOnce\ttranscribed,\tthe\tpre-mRNA\tmust\tbe\tprocessed\t(posttranscriptional\tprocessing)\tto\tform
[ -0.0019173950422555208, -0.08323676884174347, -0.025684459134936333, -0.06767628341913223, -0.04213176667690277, 0.03992607444524765, 0.07009588927030563, 0.047714222222566605, 0.0005510148475877941, -0.0023073856718838215, 0.04016922041773796, -0.03889128938317299, 0.002653747098520398, 0.06124724820256233, -0.04437587782740593, 0.01265010517090559, -0.017484989017248154, 0.014169811271131039, -0.04174981638789177, -0.09114421904087067, 0.08854236453771591, 0.0943661779165268, -0.0012800728436559439, 0.0283662136644125, 0.012764839455485344, -0.010094602592289448, -0.0328519307076931, -0.04425642639398575, 0.06011905521154404, -0.05090824514627457, -0.10036662966012955, -0.05346091464161873, 0.07081495225429535, 0.02714267559349537, 0.05872141197323799, 0.052547089755535126, -0.017268046736717224, -0.09909090399742126, 0.038503240793943405, -0.0010650717886164784, 0.08131293952465057, -0.08011756092309952, -0.06986569613218307, 0.02069243974983692, 0.0889991968870163, 0.004821298643946648, 0.018065791577100754, -0.007613237015902996, -0.05376496538519859, 0.03759663924574852, -0.07556461542844772, -0.05004429072141647, -0.08756055682897568, 0.06698813289403915, 0.02546493336558342, 0.03738580271601677, -0.022382095456123352, -0.0286547988653183, -0.008917686529457569, -0.0219850093126297, -0.04468657076358795, -0.01253566611558199, -0.02843521349132061, 0.06345054507255554, 0.10500695556402206, -0.007656135596334934, -0.019713930785655975, 0.038592636585235596, 0.012930481694638729, 0.051587678492069244, -0.031009770929813385, 0.017043257132172585, -0.09306670725345612, 0.08594253659248352, -0.001848459942266345, 0.0013610307360067964, 0.04127045348286629, 0.0019824872724711895, 0.02031259983778, -0.07759875804185867, -0.0433775819838047, 0.003311011241748929, 0.0317925326526165, 0.07822310924530029, -0.014553952030837536, 0.0395268015563488, 0.018571780994534492, 0.09051401168107986, -0.029610203579068184, 0.03267521783709526, -0.06329068541526794, 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0.010291140526533127, 0.016253594309091568, -0.06700132042169571, -0.03266587853431702, 0.010218687355518341, 0.13445203006267548, 0.04003189131617546, -0.01891663856804371, -0.015341096557676792, 0.0732574462890625, 0.01381706167012453, 0.026713907718658447, -0.005068213678896427, 0.16559937596321106, -0.009820697829127312, 0.017163636162877083, 0.048583388328552246, -0.030958516523241997, -0.05582141503691673, -0.09430538862943649, -0.07532446086406708, 0.00010509466665098444, -0.07482891529798508, -0.05149153247475624, -0.026643268764019012, 0.031216003000736237, 0.08445774018764496, -0.08980772644281387, 0.030618302524089813, -0.04124639555811882, 0.02466573379933834, -0.0035133794881403446, 0.02428439073264599, -0.05287756770849228, -0.06856594234704971, -0.06140667200088501, 0.07783590257167816, -0.0778113529086113, -0.03475988283753395, -0.0444534607231617, -0.024808989837765694, -0.012608801014721394, 0.07830699533224106, -0.03376355394721031, 0.11426938325166702, -0.11295121163129807, -0.040490247309207916, 0.001830968540161848, -0.06783037632703781, 0.06695573776960373, 0.033333174884319305, 0.10979319363832474, -0.0699741467833519, 0.028841055929660797, -0.008394510485231876, 0.03290680795907974, 0.020940128713846207, 0.012242276221513748, -0.1661793291568756, -0.11334612965583801, 0.03778486326336861, 0.08894366770982742, -0.0699557438492775, -0.010762706398963928, 0.0207529179751873, 0.005708298645913601, 0.009109887294471264, -0.022868920117616653, -0.06434881687164307, -0.026243451982736588, -0.01881205476820469, 0.09309043735265732, -0.06168299540877342, -0.03543578088283539, -0.10769421607255936, -0.0023021609522402287, -0.021869728341698647, -0.01149654109030962, 0.06624571233987808, -0.08608285337686539, 0.004159603733569384, -0.020814260467886925, 0.01460306067019701, 0.007611510809510946, -0.06638521701097488, 0.023761095479130745, -0.03833533078432083, -4.0841147972939085e-33, 0.0078065101988613605, -0.0044358219020068645, -0.014772661961615086, 0.030385935679078102, -0.06653166562318802, 0.008044201880693436, 0.06733523309230804, -0.08533493429422379, 0.05885586515069008, 0.021165238693356514, 0.03933321684598923, -0.03527088090777397, -0.041122548282146454, -0.08397344499826431, -0.05723365396261215, -0.0048825996927917, -0.02570810168981552, 0.06795662641525269, 0.0047533041797578335, 0.011271791532635689, -0.02385619655251503, 0.019511550664901733, -0.02811799757182598, 0.08663290739059448, 0.08369980752468109, 0.03691255673766136, -0.06320192664861679, 0.1089794710278511, 0.023897860199213028, 0.009503679350018501, 0.00655212439596653, -0.04033194109797478, 0.00811260286718607, 0.0193565022200346, -0.06472489982843399, 0.03961966559290886, 0.06613177806138992, 0.005321119911968708, 0.055926669389009476, -0.030918166041374207, 0.08399648219347, 0.07937057316303253, 0.03957752138376236, 0.027719564735889435, 0.03126987814903259, -0.009477379731833935, -0.06330832839012146, -0.05373740568757057, -0.01420932449400425, -0.017817825078964233, 0.08261433243751526, -0.011172669008374214, 0.00012006850010948256, 0.014237889088690281, -0.035637564957141876, -0.04900782182812691, 0.018004273995757103, -0.001869112253189087, -0.026606615632772446, -0.00712798535823822, -0.022359661757946014, -0.06180242449045181, 0.05397916957736015, 0.020836373791098595, 0.04275399446487427, -0.012743017636239529, -0.015164573676884174, -0.01699325069785118, 0.030779050663113594, -0.08023461699485779, 0.027367956936359406, 0.02843768335878849, 0.006670572329312563, -0.055721260607242584, 0.09247486293315887, -0.032620567828416824, -0.08353801816701889, -0.011613431386649609, -0.002802156610414386, -0.025716710835695267, -0.11640458554029465, 0.019872624427080154, -0.003582579782232642, -0.0035781681071966887, 0.011225472204387188, 0.02866221033036709, -0.004479608032852411, 0.03532791882753372, 0.07587172836065292, 0.029195228591561317, -0.017286498099565506, 0.06002264842391014, -0.05133149400353432, 0.0830802246928215, 0.0024780374951660633, -3.748205656961545e-8, 0.033681128174066544, -0.04138006269931793, 0.05913854017853737, -0.023887217044830322, 0.058853305876255035, 0.04463868960738182, -0.005024799145758152, 0.039733923971652985, 0.05591629073023796, -0.0389876626431942, 0.002249708864837885, 0.012483849190175533, -0.09352581948041916, -0.022446900606155396, 0.10646284371614456, -0.0023530242033302784, -0.0723428875207901, -0.0058440775610506535, 0.0019067756365984678, -0.07538776844739914, 0.025898266583681107, 0.016944119706749916, -0.0957702025771141, 0.07711944729089737, -0.039854347705841064, -0.06955254822969437, 0.02220074087381363, 0.05086958035826683, 0.011603347957134247, -0.003805134678259492, 0.01771281473338604, -0.01686062663793564, -0.00899047963321209, -0.0980842262506485, -0.02107871137559414, 0.023803947493433952, 0.08614879846572876, -0.055282603949308395, -0.034157536923885345, 0.07149417698383331, 0.0014363998780027032, 0.047679353505373, -0.061393242329359055, -0.002462621545419097, 0.04639710485935211, -0.00155655387789011, -0.017596138641238213, 0.034809671342372894, -0.038634292781353, -0.09242048859596252, 0.043964918702840805, 0.05137726292014122, -0.022619225084781647, 0.01001656986773014, -0.06192532181739807, 0.018286334350705147, 0.03197870030999184, -0.05734750255942345, 0.03219068795442581, -0.01602889783680439, 0.01616453379392624, 0.08626260608434677, 0.1287662237882614, -0.08658283948898315 ]
mature\t\nmessenger\tRNA\t(mRNA)\n\tfrom\twhich\tthe\n\tintrons\thave\tbeen\tremoved\tand\tthe\tnucleotide\nsequence\tof\tthe\tmRNA\tis\tready\tto\tbe\ttranslated\tinto\tthe\tamino\tacid\tsequence\tof\tthe\tencoded\nprotein.\tThe\tprotein\tsynthesis\tprocess\tis\tcalled\t\ntranslation\n.\tEach\tset\tof\tthree\tnucleotides\tmakes\tup\na\t\ncodon
[ -0.028483957052230835, -0.10969621688127518, 0.005660166032612324, -0.06031623110175133, -0.12755107879638672, -0.002090816618874669, 0.015122069977223873, 0.01374231930822134, -0.00993301160633564, 0.12398044019937515, 0.1217069998383522, -0.04276993125677109, -0.033801715821027756, 0.0432182177901268, -0.053182203322649, 0.0805000588297844, -0.09785959869623184, -0.006820064038038254, 0.014290888793766499, -0.06297136843204498, 0.04586354270577431, 0.1578124761581421, 0.060846857726573944, -0.026217469945549965, 0.0019353280076757073, 0.01581302471458912, -0.059696901589632034, -0.01431109756231308, 0.0068562645465135574, -0.03233758732676506, -0.10698776692152023, 0.0482812337577343, 0.06349916756153107, -0.003337570931762457, 0.04261321201920509, 0.006812524050474167, -0.042050234973430634, -0.005299095530062914, 0.11705231666564941, 0.041096050292253494, 0.050000037997961044, -0.03421967104077339, -0.021728143095970154, 0.04812418296933174, 0.060574211180210114, 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0.004774338565766811, -0.056107670068740845, 0.05873279273509979, 0.016787532716989517, -0.05522866174578667, -0.00019212905317544937, 0.09110724925994873, -0.03703121095895767, -0.07772218436002731, 0.0026716457214206457, 0.07883800566196442, -0.006956117693334818, -0.0776212140917778, -0.04874939098954201, 0.036375291645526886, 0.05734122917056084, 0.01397883240133524, -0.0247198436409235, 0.02871701680123806, 0.04477532207965851, 0.05978519842028618, 0.11333873867988586, -0.041366394609212875 ]
translation\n.\tEach\tset\tof\tthree\tnucleotides\tmakes\tup\na\t\ncodon\n,\twhich\tin\tturn\tspecifies\ta\tparticular\tamino\tacid\tand\tits\tposition\twithin\tthe\tprotein\t(\nFigs.\t6.3\nand\t\n6.4\n).\tFollowing\ttranslation,\tmost\tproteins\tneed\tfurther\n\tprocessing\t(\nposttranslational\nmodification\n)\tbefore\tthey\tare\tactive.\tThis\toccurs\twith\tproenzyme\tand\tprohormones\tthat\tmust\tbe
[ -0.01200702041387558, -0.0528547577559948, 0.04491226375102997, -0.08087524771690369, -0.09408652037382126, 0.007861766964197159, 0.032527074217796326, 0.033128149807453156, 0.003104701405391097, 0.09265489876270294, 0.13887478411197662, -0.022748293355107307, -0.013540852814912796, 0.052118249237537384, -0.04479793459177017, 0.02756255865097046, -0.06798270344734192, 0.060503799468278885, -0.027743156999349594, -0.05247386172413826, 0.06591733545064926, 0.10262133926153183, 0.026866821572184563, 0.02255093678832054, 0.04968320578336716, 0.014284425415098667, -0.05252904072403908, -0.04492947831749916, 0.030443787574768066, -0.06189625710248947, -0.13907890021800995, 0.031061096116900444, 0.012271814979612827, -0.004239031113684177, 0.07281461358070374, 0.05114702880382538, -0.036483753472566605, -0.014800012111663818, 0.08904741704463959, 0.04618704691529274, 0.001006911974400282, -0.06651473045349121, -0.03581118956208229, 0.019383803009986877, 0.10473628342151642, 0.014546814374625683, 0.0023511224426329136, -0.010256290435791016, -0.025233464315533638, -0.009718623012304306, -0.09621245414018631, -0.053797513246536255, -0.09623822569847107, 0.06814258545637131, -0.008853960782289505, -0.007390549872070551, 0.003209780901670456, -0.04684854671359062, -0.01835061050951481, -0.012194309383630753, 0.00660695880651474, 0.015466275624930859, -0.07111790776252747, 0.03821546211838722, 0.025276627391576767, 0.02826887182891369, 0.048671163618564606, 0.00030514568788930774, -0.024704502895474434, 0.11314640939235687, -0.013486374169588089, 0.006432674825191498, 0.004831370897591114, 0.11360180377960205, -0.042994990944862366, 0.012405969202518463, 0.07803168892860413, -0.023605722934007645, -0.027358653023838997, -0.07360482960939407, -0.06753496825695038, 0.08312895894050598, 0.04139570891857147, 0.008879219181835651, -0.031054256483912468, 0.026194743812084198, -0.005960933398455381, 0.0756029486656189, 0.025760188698768616, 0.054676614701747894, 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0.09281067550182343, -0.0632985383272171, 0.0006775917136110365, 0.0481792651116848, -0.07684767246246338, 0.0714678168296814, -0.04553910717368126, 0.053918298333883286, -0.03351502865552902, 0.029963340610265732, 0.013012686744332314, -0.027879592031240463, 0.0523783303797245, 0.0021613070275634527, -0.17562077939510345, -0.08397632092237473, 0.07788695394992828, 0.013493895530700684, -0.11990102380514145, -0.024306947365403175, -0.014872702769935131, 0.03725701570510864, 0.06831158697605133, -0.01881936937570572, 0.02126098982989788, -0.059688467532396317, -0.0010161575628444552, -0.021905187517404556, -0.0858650803565979, -0.02061319164931774, -0.05991360545158386, -0.026137810200452805, -0.015157802030444145, -0.00021426340390462428, 0.04973180219531059, -0.06869925558567047, 0.026600230485200882, 0.04238284006714821, -0.015722112730145454, 0.024455247446894646, -0.03694755584001541, -0.03237391263246536, -0.07489009946584702, -2.418470526247421e-33, -0.02721402607858181, 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0.07051894813776016, 0.004723211284726858, 0.1124223843216896, 0.06467384845018387, -4.932705266469384e-8, 0.012577870860695839, -0.011214413680136204, 0.014046352356672287, -0.020173436030745506, 0.07402104884386063, -0.020693156868219376, 0.0092323562130332, 0.0380844883620739, -0.016438351944088936, -0.03557654097676277, 0.0005223792977631092, 0.09821956604719162, -0.08283000439405441, -0.04459545761346817, 0.06960470229387283, 0.013713087886571884, 0.003012235276401043, 0.05419225990772247, -0.015846306458115578, -0.046742212027311325, -0.01814720220863819, 0.06905419379472733, -0.06176699697971344, 0.010660342872142792, -0.033892206847667694, 0.007991930469870567, -0.01204594224691391, 0.010456638410687447, 0.02220948413014412, -0.003047191770747304, 0.036824584007263184, -0.019109591841697693, -0.017676524817943573, -0.04155990108847618, -0.016498271375894547, 0.023344499990344048, -0.03700725734233856, -0.04629986360669136, 0.021146634593605995, 0.12486986070871353, 0.03409286215901375, -0.0055393013171851635, -0.05935927480459213, 0.06314461678266525, 0.027976876124739647, -0.06717795878648758, -0.05854456126689911, 0.08844513446092606, -0.03012685663998127, -0.08316917717456818, 0.01120495144277811, 0.0671980008482933, -0.05159527808427811, -0.04646238684654236, -0.04576601833105087, 0.028543971478939056, 0.11445393413305283, -0.03832733631134033, -0.003063778392970562, 0.013175969012081623, 0.0303350742906332, 0.07284677773714066, 0.10816679894924164, -0.04367448762059212 ]
enzymatically\tprocessed\tbefore\tbecoming\tactive\tor\tother\tproteins\tthat\tare\tphosphorylated\tor\nglycosylated\tprior\tto\tbeing\tfunctional.\nFIG.\t6.3\nDNA\tGenetic\t\nCode\tDictates\tAmino\tAcid\tIdentity\tand\tOrder.\n\t\nAll\tliving\torganisms\tare\tcomposed\nlargely\tof\tproteins.\tProteins\tare\tlarge,\tcomplex\tmolecules\tmade\tup\tof\tlong\tchains\tof\tsubunits\tcalled\tamino
[ -0.07792062312364578, -0.044383857399225235, 0.018081869930028915, -0.06776876747608185, -0.06985031813383102, -0.006624246947467327, 0.0173973198980093, 0.020002545788884163, -0.04835755005478859, 0.06841815263032913, 0.1646687239408493, -0.015850266441702843, -0.007524877320975065, 0.010368434712290764, -0.09239976853132248, 0.02153477445244789, -0.10229115933179855, 0.07019519805908203, -0.05413399636745453, -0.03226308524608612, 0.03502728044986725, 0.09194137901067734, 0.04949699342250824, -0.00031200857483781874, 0.0031486141961067915, -0.0449909083545208, -0.038898490369319916, -0.001693452475592494, 0.00981391966342926, -0.10522081702947617, -0.11395646631717682, 0.06346099078655243, -0.07441656291484833, -0.02761228196322918, 0.09013569355010986, 0.04081234335899353, -0.008602309972047806, 0.008368809707462788, 0.09320337325334549, -0.01426323689520359, 0.0688094049692154, -0.07059002667665482, -0.05520867556333542, 0.06006578728556633, 0.008251622319221497, 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0.006986592896282673, -0.038642991334199905, 0.0063694193959236145, -0.06254354119300842, -0.04403509572148323, 0.0001990362798096612, 0.023190876469016075, 0.0009082939359359443, 0.014057130552828312, -0.0635644942522049, -0.01898210309445858, -0.02964238077402115, 0.03178587555885315, -0.038374509662389755, -0.0344829335808754, -0.016561174765229225, -0.06761571764945984, -0.043548211455345154, 0.04526589810848236, 0.0170849971473217, -0.05458554998040199, 0.03474877029657364, 0.052143700420856476, -0.05538111552596092, -0.009747028350830078, -0.011949804611504078, -0.026176493614912033, 0.007299039512872696, 0.12367142736911774, 0.005427722353488207, 0.01673559471964836, 0.006597048137336969, 0.062408335506916046, 0.05217529460787773, -0.06586367636919022, -0.020394058898091316, -0.037133462727069855, 2.5964862887099942e-33, 0.05766740441322327, 0.03789366036653519, 0.035739827901124954, 0.11806201189756393, 0.011524397879838943, 0.010574745014309883, -0.013737725093960762, 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0.09236250072717667, -0.03582543507218361, -0.03773614391684532, 0.003292535897344351, -0.03423512354493141, 0.04847516864538193, 0.009230373427271843, 0.10407565534114838, 0.004767701029777527, 0.06331072002649307, -0.02057146094739437, -0.023367810994386673, 0.07495526969432831, 0.008376894518733025, -0.12139281630516052, -0.05345972254872322, -0.007288624532520771, 0.0395602248609066, -0.07034484297037125, -0.0626177191734314, 0.027537794783711433, 0.02990938164293766, 0.0768033117055893, 0.001131474389694631, -0.009324866347014904, -0.06680553406476974, -0.03738132864236832, -0.010001812130212784, -0.051315173506736755, -0.01621617004275322, -0.045640118420124054, -0.03083815984427929, -0.027523986995220184, -0.03998788818717003, 0.0045199766755104065, -0.017626067623496056, -0.011310416273772717, 0.00830797292292118, 0.07070242613554001, 0.017569206655025482, -0.04058985412120819, -0.07383010536432266, -0.11916966736316681, -4.3165283975507064e-33, 0.002761312760412693, -0.06470715999603271, 0.0282512828707695, 0.007599281147122383, -0.057740218937397, 0.012966381385922432, -0.011764519847929478, 0.012444742023944855, 0.057853177189826965, -0.05217479169368744, 0.08824662119150162, 0.0021817730739712715, -0.008212495595216751, -0.14436504244804382, -0.04336569458246231, -0.014109067618846893, -0.005592829082161188, 0.07986665517091751, 0.030511660501360893, 0.033526383340358734, -0.09424346685409546, 0.0294608473777771, -0.09512124955654144, 0.08680790662765503, 0.05056750774383545, 0.029175197705626488, 0.006001063156872988, 0.06298527866601944, 0.08199162036180496, 0.030743205919861794, 0.01813330315053463, -0.03091421350836754, -0.020423879846930504, 0.04259755089879036, -0.012342503294348717, 0.02041463926434517, 0.053372275084257126, 0.005301427096128464, 0.051331281661987305, 0.008038328029215336, 0.01563003472983837, 0.049658238887786865, -0.0028471772093325853, -0.019444312900304794, 0.028842156752943993, -0.015724029392004013, -0.09261858463287354, -0.043847281485795975, -0.007051348220556974, 0.02011793665587902, 0.12799040973186493, -0.0012872656807303429, -0.031077709048986435, -0.035167716443538666, 0.033711496740579605, -0.02376776747405529, -0.027518387883901596, -0.05695545673370361, -0.013545786030590534, 0.02182701788842678, -0.009612685069441795, -0.05590027570724487, 0.022948404774069786, -0.013083402067422867, 0.011528766714036465, 0.015020690858364105, -0.13479217886924744, -0.026989813894033432, -0.016551723703742027, -0.03934626281261444, -0.0026390738785266876, 0.02830885723233223, -0.04533430188894272, -0.10876792669296265, 0.09015060216188431, -0.030652539804577827, -0.004923858214169741, -0.04795872047543526, 0.021494045853614807, -0.03754899650812149, -0.014475046657025814, 0.0015644457889720798, 0.007163285743445158, 0.013619255274534225, 0.037136539816856384, -0.03203341364860535, 0.04633079841732979, 0.04143161326646805, 0.05543587729334831, -0.01692827232182026, 0.024579716846346855, 0.01985033228993416, -0.01851489767432213, 0.13235579431056976, 0.10963714122772217, -4.362425087833799e-8, 0.08284728229045868, -0.02472042292356491, 0.05242061987519264, -0.05988073721528053, 0.05627680942416191, 0.06844330579042435, 0.03478531166911125, 0.0652511939406395, 0.020487051457166672, -0.05424884706735611, 0.013064485974609852, 0.08469608426094055, -0.050258833914995193, 0.006445367354899645, 0.08626075834035873, 0.01757846213877201, -0.05702603608369827, 0.06361810117959976, -0.019548464566469193, -0.013722297735512257, -0.00043012830428779125, 0.07150733470916748, -0.06975219398736954, 0.04181431606411934, 0.01350781973451376, 0.00413948018103838, 0.03309352323412895, -0.02449977956712246, 0.006970688700675964, -0.0068313912488520145, 0.029738783836364746, -0.060500748455524445, -0.051534734666347504, -0.031640149652957916, -0.05637602508068085, 0.04773259907960892, -0.0445544570684433, -0.04813143238425255, 0.003800387028604746, 0.13039937615394592, -0.0035688402131199837, -0.010470599867403507, -0.1109810397028923, 0.037460166960954666, 0.036924175918102264, -0.04545418173074722, -0.04068507254123688, 0.10069061070680618, -0.07684603333473206, -0.04546228423714638, 0.023992111906409264, 0.07662352919578552, -0.0016546323895454407, -0.07220422476530075, -0.0761648640036583, 0.04529036581516266, 0.09617658704519272, 0.009398904629051685, -0.014501265250146389, -0.037358447909355164, 0.03614910691976547, 0.02181924879550934, 0.13183970749378204, -0.025172313675284386 ]
acids.\tTwenty\tdifferent\tkinds\tof\tamino\tacids\tare\tusually\tfound\tin\tproteins.\tWithin\tthe\tgene,\teach\tspecific\nsequence\tof\tthree\tdeoxyribonucleic\tacid\tbases\t(codons)\tdirects\tthe\tcells\tprotein-synthesizing\n\tmachinery\tto\nadd\tspecific\tamino\tacids.\tFor\texample,\tthe\tbase\tsequence\tATG\tcodes\tfor\tthe\tamino\tacid\tmethionine.
[ 0.0020839173812419176, -0.07232054322957993, 0.018741318956017494, -0.06608833372592926, -0.10329212248325348, 0.024819038808345795, 0.03716687113046646, 0.033847518265247345, 0.024750715121626854, 0.061866503208875656, 0.10159874707460403, -0.057208798825740814, 0.02641281671822071, 0.02663104236125946, -0.05140407755970955, 0.004796263296157122, -0.0715399980545044, 0.06119057163596153, -0.013337810523808002, -0.05856193229556084, 0.04177402704954147, 0.13029694557189941, 0.03892691805958748, 0.03030608780682087, -0.007527397479861975, 0.033513035625219345, -0.01679186150431633, 0.009291067719459534, 0.006662032566964626, -0.06568378955125809, -0.12169241905212402, 0.04830426350235939, 0.022761475294828415, -0.002306781942024827, 0.08489342033863068, 0.014559371396899223, -0.03643478825688362, -0.0015532096149399877, 0.10417206585407257, 0.04114648327231407, 0.01246521808207035, -0.04887210577726364, -0.019025012850761414, 0.035142313688993454, 0.04006827995181084, 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Because\tthree\tbases\tcode\tfor\tone\tamino\tacid,\tthe\tprotein\tcoded\tby\tan\taverage-sized\tgene\t(3000\tbp)\ncontains\t1000\tamino\tacids.\tThe\tgenetic\tcode\tis\tthus\ta\tseries\tof\tcodons\tthat\tspecify\twhich\tamino\tacids\tare\nrequired\tto\tmake\tup\tspecific\tproteins.\t\nA,\n\tadenine;\t\nbp,\n\tbase\tpairs;\t\nC,\n\tcytosine;\t\nG,\n\tguanine;\t\nT,\nthymine.\n\tSource:
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bp,\n\tbase\tpairs;\t\nC,\n\tcytosine;\t\nG,\n\tguanine;\t\nT,\nthymine.\n\tSource:\t\n(From\tU.S.\tDepartment\tof\tEnergy,\tHuman\tGenome\tProgram:\t\nwww.ornl.gov/hgmis\n.)\nFIG.\t6.4\nDNA\t\nSequence\tVariation\tin\tGenes\tCan\tChange\tthe\tProtein\tProduced.\n\t\nHuman\tbeings\tdiffer\tfrom
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Human\tbeings\tdiffer\tfrom\neach\tother\tin\tonly\tan\testimated\t0.1%\tof\tthe\ttotal\tsequence\tof\tnucleotides\tthat\tcompose\tdeoxyribonucleic\nacid.\tThese\tvariations\tin\tgenetic\tinformation\tare\tthought\tto\tbe\tthe\tbasis\tfor\tthe\tphysical\tand\tfunctional\ndifferences\tbetween\tindividuals.\tSome\tvariations\tin\ta\tperson’s\tgenetic\tcode\twill\thave\n\tno\teffect\ton\tthe\tprotein
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-0.011900053359568119, -0.021679574623703957, 0.008555339649319649, -0.07046724855899811, 0.04216742888092995, 0.053280483931303024, 0.03286830335855484, 0.002265702234581113, -0.0165680143982172, 0.05882049351930618, 0.03140402212738991, -0.0047506713308393955, -0.09943970292806625, -0.05848713219165802, -0.03707599639892578, -0.009880123659968376, 0.10435060411691666, 0.0024172954726964235, 0.03867344930768013, -0.030107827857136726, 0.021814502775669098, -0.12909835577011108, 0.05939740687608719, 0.0319090411067009, 0.041399843990802765, 0.018435638397932053, 0.020441485568881035, 0.032362233847379684, 0.035916127264499664, 0.033951535820961, -0.006651006639003754, -0.01463896781206131, 0.0008082028944045305, 0.055546753108501434, -0.0013502512592822313, 0.07853755354881287, 0.009442461654543877, -0.0232688058167696, -0.004213178995996714, 0.026762250810861588, 0.03962106257677078, 0.002630871254950762, -0.004099734593182802, 0.03642110526561737, 0.009980532340705395, -0.08554612100124359, -0.04236029088497162, -0.03135274723172188, 0.05345333740115166, 0.0978100374341011, -0.006538842339068651, -0.03962448611855507, -0.019387897104024887, 0.027576053515076637, -0.026077738031744957, 0.02852777950465679, -0.08045372366905212, -0.007004053331911564, 0.06708948314189911, -0.010872281156480312, -0.0336967408657074, 0.016131186857819557, 0.040099579840898514, 0.024513432756066322, -0.04180774465203285, -0.08754423260688782, 0.014101911336183548, 0.003343285759910941, -0.04832756519317627, -0.004377859178930521, -0.009536385536193848, -0.04574774578213692, -0.1190151795744896, 0.09335096925497055, -0.04732855036854744, -0.01727220229804516, -0.048312265425920486, 0.01692085713148117, -0.022945649921894073, -0.03164685145020485, -0.08173785358667374, 0.03351284936070442, 0.04344216361641884, 0.02887512370944023, -0.05279112234711647, 0.05488118156790733, 0.05478329956531525, 0.020380573347210884, 0.04772861301898956, 0.0023062347900122404, 0.026004347950220108, -0.028716424480080605, 0.06876447051763535, 0.07479334622621536, -4.558818744726523e-8, 0.03300164267420769, -0.04138766974210739, 0.05400506779551506, -0.025268057361245155, 0.06750007718801498, 0.03554662689566612, 0.019394833594560623, 0.041470687836408615, 0.0023346375674009323, -0.04296225309371948, 0.022536827251315117, 0.09821151942014694, -0.0740455612540245, -0.014399856328964233, 0.12492455542087555, 0.028773482888936996, 0.007559729274362326, 0.056090906262397766, -0.016642920672893524, -0.023391932249069214, -0.020831240341067314, 0.09286317229270935, -0.08577089011669159, -0.006993360351771116, -0.05809682980179787, 0.0387871079146862, 0.011538282036781311, 0.006456449162214994, -0.025223692879080772, -0.0194380022585392, 0.034916311502456665, -0.03545296937227249, -0.04733625426888466, -0.06533131003379822, 0.002555567305535078, 0.0640282854437828, -0.07072225213050842, -0.06495150178670883, 0.041440047323703766, 0.12117547541856766, 0.01205411832779646, 0.022813396528363228, -0.055998239666223526, 0.04851469397544861, 0.09915024042129517, -0.0721619501709938, -0.0305361095815897, 0.05937511473894119, -0.025421757251024246, -0.04702283442020416, -0.02202538214623928, 0.06935269385576248, -0.025396574288606644, -0.05490261688828468, -0.056061021983623505, 0.00009353897621622309, 0.09845627844333649, 0.047123752534389496, -0.0295510683208704, 0.02001187764108181, 0.10525870323181152, 0.07590768486261368, 0.07722525298595428, -0.03049485757946968 ]
no\teffect\ton\tthe\tprotein\nthat\tis\tproduced;\tothers\tcan\tlead\tto\tdisease\tor\tan\tincreased\tsusceptibility\tto\ta\tdisease.\n\tSource:\t\n(From\tU.S.\nDepartment\tof\tEnergy,\tHuman\tGenome\tProgram:\t\nwww.ornl.gov/hgmis\n.)\nInvestigation\tof\tthese\tdownstream\tsteps\tin\tthe\tgene\texpression\tprocess\thas\tcreated\tnew\tfields,\noften\tcalled\tthe\t“omics”\t(\nHasin\tet\tal,\t2017
[ -0.04264495149254799, -0.01690959930419922, 0.024479303508996964, -0.06002148985862732, -0.02675614133477211, -0.0087056839838624, 0.0926283672451973, -0.006704750936478376, 0.02479882910847664, 0.02280430682003498, 0.08335031569004059, 0.024724081158638, 0.08059000968933105, -0.008699641562998295, -0.0138432327657938, 0.05327384173870087, -0.030655235052108765, 0.025729065760970116, -0.03477896749973297, -0.06963125616312027, 0.0809098333120346, 0.08981161564588547, -0.007188733201473951, -0.028991542756557465, 0.01492355391383171, 0.07009673863649368, -0.07364724576473236, -0.027928519994020462, 0.02649264596402645, -0.06878453493118286, -0.09170687943696976, 0.01657778210937977, -0.02578638307750225, 0.006621215958148241, 0.07952674478292465, 0.0736505389213562, -0.020962756127119064, 0.02810771018266678, 0.002558425534516573, 0.02884218841791153, -0.02384258806705475, -0.09553022682666779, -0.09331364929676056, 0.028404103592038155, 0.028167251497507095, -0.006767782848328352, 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-0.05966692045331001, 0.04771527647972107, -0.09328707307577133, -0.012154800817370415, -0.024383261799812317, 0.07966621220111847, 0.007497706450521946, -0.08176743984222412, -0.0015268005663529038, 0.04460844770073891, -0.0011862904066219926, -0.03423964977264404, -0.01663403958082199, 0.12176144868135452, 0.0057595157995820045, 0.02388111688196659, -0.042842816561460495, 0.001369581208564341, -0.0026663271710276604, -0.029914606362581253, 0.028995642438530922, 0.025250041857361794, 0.05828385427594185, -0.08665536344051361, -0.01731056347489357, 0.005501095671206713, 0.02417159639298916, 0.02336294949054718, 0.017484460026025772, -0.02582043781876564, 0.046498045325279236, -0.034127864986658096, -0.08561911433935165, 0.002454250818118453, -0.0049833511002361774, 0.021731248125433922, 0.03764379024505615, 0.004330072086304426, -0.037294261157512665, -0.025238560512661934, -0.010552003048360348, -0.0400255061686039, 0.04601993039250374, -0.011559166945517063, 0.08340313285589218, -0.000138724222779274, -0.003697087289765477, 0.011812820099294186, -0.03744158521294594, 0.014931648969650269, 0.04011540859937668, 0.03338068723678589, -0.017718356102705002, 0.09372183680534363, 0.00038310690433718264, -0.0444004088640213, 0.04623933136463165, -0.008136543445289135, -0.04920826479792595, -0.04079313948750496, 0.06659245491027832, 0.014049340970814228, -0.08532989025115967, 0.026563461869955063, -0.020097646862268448, 0.06557675451040268, 0.004961109254509211, -0.014963424764573574, -0.010563462972640991, -0.05837932974100113, 0.04973805695772171, -0.03209136053919792, -0.05091875046491623, -0.03425922989845276, -0.01928546093404293, -0.0016126529080793262, 0.0005780989886261523, -0.032171331346035004, 0.019233712926506996, -0.07710372656583786, -0.021695254370570183, -0.02292277291417122, -0.022580407559871674, 0.056029822677373886, -0.006484008394181728, -0.04847217723727226, -0.11974275857210159, -3.3715055099124675e-33, -0.05495135113596916, -0.05552167445421219, -0.06183334439992905, 0.04061385244131088, -0.0652216374874115, -0.005361484829336405, 0.019274452701210976, 0.026255721226334572, 0.06173103302717209, -0.00017088833556044847, 0.08554311096668243, -0.022938450798392296, -0.04058869555592537, -0.1250818818807602, -0.006627887487411499, 0.008798602968454361, -0.02615888975560665, 0.1094123050570488, -0.07121806591749191, 0.03155609592795372, -0.08488607406616211, 0.0414535254240036, -0.13732212781906128, 0.05567658320069313, 0.0165077093988657, 0.035557299852371216, 0.00943689327687025, 0.022562168538570404, 0.04801405221223831, 0.07136277109384537, 0.032684992998838425, -0.001083988812752068, -0.07161802798509598, 0.06181132793426514, -0.026925384998321533, 0.03687112405896187, 0.08755499124526978, 0.033764343708753586, -0.021549738943576813, -0.05511065199971199, 0.04644143581390381, 0.027772510424256325, 0.06683579087257385, -0.0017504323041066527, -0.03674158826470375, -0.0060278670862317085, -0.13994096219539642, 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0.008519205264747143, 0.14320255815982819, 0.04703313484787941, -5.97258136281198e-8, -0.01056642085313797, -0.053776804357767105, 0.056344978511333466, 0.00982389785349369, 0.04208478704094887, -0.002854759804904461, 0.05106698349118233, 0.0026792765129357576, -0.042332880198955536, -0.05971105769276619, 0.0167183019220829, 0.0758923664689064, -0.16071869432926178, -0.07134705781936646, 0.09566747397184372, 0.03199044615030289, -0.012864232994616032, 0.057601701468229294, -0.027647076174616814, -0.05302605777978897, 0.01161616574972868, 0.1075957641005516, -0.04176701232790947, 0.04330229014158249, 0.006913428194820881, 0.0038643144071102142, 0.030369188636541367, 0.013193159364163876, 0.044405460357666016, -0.004512036684900522, 0.0103020453825593, -0.021985018625855446, -0.03190517798066139, -0.01713215559720993, -0.04491959512233734, 0.05955912172794342, 0.007525127846747637, -0.048832762986421585, -0.016200104728341103, 0.08453213423490524, 0.009592524729669094, 0.020954784005880356, -0.012485433369874954, 0.06923719495534897, 0.03902292624115944, -0.04417327418923378, -0.049702730029821396, 0.03890709578990936, -0.006279750727117062, -0.07262269407510757, 0.0005849266308359802, 0.10322540998458862, 0.02327777072787285, -0.008264632895588875, -0.07016799598932266, 0.022597933188080788, 0.0665397197008133, 0.0041673737578094006, 0.0002802647359203547, 0.01304646860808134, 0.05979907512664795, 0.06866511702537537, 0.14084716141223907, -0.014615618623793125 ]
often\tcalled\tthe\t“omics”\t(\nHasin\tet\tal,\t2017\n).\tThese\tdisciplines\tcorrelate\twith\tthe\tmajor\tsteps\tin\n\tthe\nprocess\tof\tgenetic\tinformation\tretrieval\tand\ttranslation:\ttranscriptomics,\tposttranscriptional\tand\nposttranslational\tprocessing,\tproteomics,\tmetabolomics,\tand\tepigenomics\t(see\t\nBox\t6.2\n).\nGenomic\tregulation\tof\tgene\texpression
[ -0.0292651429772377, -0.04590360447764397, -0.011206874623894691, -0.023623710498213768, -0.05423852428793907, -0.0002819766814354807, 0.042553387582302094, 0.039990298449993134, 0.04249614104628563, 0.04476822912693024, 0.06785231828689575, -0.003550079185515642, -0.006789369508624077, 0.03669862449169159, -0.03167746216058731, 0.037308380007743835, -0.08423954993486404, 0.06257378309965134, -0.01891603134572506, -0.06685899198055267, 0.038490016013383865, 0.112479567527771, 0.03257845714688301, -0.016095619648694992, 0.01720832847058773, 0.011466937139630318, -0.04235907271504402, -0.03426358103752136, 0.018157852813601494, -0.010293377563357353, -0.08293910324573517, 0.11550889164209366, -0.0026483661495149136, 0.027150815352797508, 0.0703955814242363, 0.05281054228544235, -0.042282912880182266, 0.025642242282629013, 0.04410336911678314, -0.0064633674919605255, -0.017323266714811325, -0.07804346084594727, -0.041673220694065094, 0.02156938798725605, 0.09972631931304932, 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In\thigher\torganisms\tsuch\tas\thuman\tbeings,\tthe\texpression\tof\tthe\tinformation\tencoded\twithin\tthe\ngenes\tis\tregulated\tat\tthe\tchromosome\tlevel\tand\tat\tthe\tDNA\tlevel.\tIn\tboth\n\tcases\tthe\tstrategy\tis\tthe\nsame:\tphysically\tblock\tor\tallow\taccess\tto\tthe\tgenes\tin\torder\tto\tprevent\tor\tallow\tthe\texpression\tof
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0.019713984802365303, -0.015503467060625553, 0.08162124454975128, 0.062399398535490036, -0.05163094773888588, 0.0426226407289505, 0.054677873849868774, -0.023394905030727386, -0.04582509025931358, 0.003086409531533718, 0.11511372029781342, 0.0073172529228031635, -0.03395863622426987, -0.040461216121912, 0.007377909496426582, 0.021225949749350548, 0.06250770390033722, -0.07630116492509842, 0.02694096788764, 0.06117699667811394, 0.017513370141386986, 0.09157313406467438, -0.03201387822628021 ]
genes.\tAs\tdescribed\tearlier,\tthe\tlarge\tamount\tof\tDNA\tin\tthe\tgenome\tis\tcondensed\tand\tnot\tavailable\nfor\ttranscription.\tThe\tregion\tof\tthe\tchromosome\tto\tbe\ttranscribed\tmust\tfirst\tbe\topened\t(relaxed)\nbefore\tRNA\tpolymerase\tcan\taccess\tthe\tpromoter\tof\tthe\tgene\tof\tinterest.\tThe\tattachment\n\tof\tacetyl\tor
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of\tacetyl\tor\nother\tchemical\tgroups\tto\tthe\thistone\tproteins\trelaxes\tthe\tchromosome\tand\tpermits\taccess\tto\tthe\nDNA.\tIn\tthe\tabsence\tof\tthe\tattachment\tof\tthese\tchemical\tgroups,\tthe\tchromosome\tstays\tcondensed,\nthe\tpromoter\tis\tnot\taccessible,\tand\tthe\tgene\tis\tnot\texpressed\t(\nFig.\t6.5\n).\nFIG.\t6.5
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Fig.\t6.5\n).\nFIG.\t6.5\nEpigenetic\tregulation\tof\tgene\texpression\tthrough\thistone\tmodification\tand\tDNA\nmethylation.\n\tSource:\t\n(Image\tcredit:\tDarryl\tLeja,\tNational\tHuman\tGenome\tResearch\tInstitute,\tNIH.)\nA\tsimilar\tprocess\tis\tused\tat\tthe\tDNA\tlevel\tfor\tpromoting\tor\tinhibiting\ttranscription\tonce\tthe
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chromosome\thas\trelaxed\texcept\tthat\tthe\tchemical\tgroup\tis\tfrequently\ta\tmethyl\tgroup.\tRecall\tthe\narchitecture\tof\ta\n\ttypical\tgene\tas\thaving\ta\tregulatory\tregion,\ta\tpromoter\tregion,\tand\ta\tcoding\tregion.\nWhen\tmethyl\tgroups\tare\tattached\tto\tthe\tDNA\tin\tthe\tpromoter\tregion,\tthe\tRNA\tpolymerase\tis
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physically\tblocked\tfrom\tattaching\tand\tinitiating\ttranscription.\tFor\ttranscription\tto\toccur\tin\thigher\norganisms,\tmethyl\tgroups\tmust\tbe\tremoved,\tand\tspecialized\tproteins\tcalled\ttranscription\tfactors\nmust\tbind\tto\tthe\tDNA\tin\tthe\tregulatory\n\tregion.\tTranscription\tfactors\thave\ta\tDNA\tbinding\tsite\tand\ta
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region.\tTranscription\tfactors\thave\ta\tDNA\tbinding\tsite\tand\ta\nligand\tbinding\tsite.\tThis\tlatter\tsite\tcan\tbind\ta\tsmall\tmolecular\tweight\t“sensor”\tmolecule\t(a\t\nligand\n)\nthat\tchanges\tthe\tconformation\tof\tthe\ttranscription\tfactor\tand\tchanges\tits\tability\tto\tbind\tto\tDNA.\tIn
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higher\torganisms\tbinding\tmay\tinvolve\tmultiple\ttranscription\tfactors,\teach\tbinding\tits\tspecific\tligand.\nDepending\ton\tthe\tgene,\tmultiple\n\ttranscription\tfactors\tmay\tconnect\twith\tDNA\tindividually\tor\tform\ta\ncomplex\tthat\tthen\tallows\tattachment\tto\tthe\tDNA.\tThe\texpression\tof\tsome\tgenes\tis\tactivated\tby\tthe\ncomplex\tand\tfor\tothers\ttranscription\tis\tsilenced.
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complex\tand\tfor\tothers\ttranscription\tis\tsilenced.\nFood\tplays\tkey\troles\tin\tthe\tregulation\tof\tgene\texpression.\tThe\tacetyl\tand\tmethyl\tgroups\toriginate\nfrom\tfood\tand\tmany\tof\tthe\tligands\tthat\tbind\tto\ttranscription\tfactors\tare\tderived\tfrom\n\tfood.\tFood\tis\nan\timportant\tsource\tof\tinformation\tfor\tall\torganisms\tto\t“sense”\tand\trespond\tto\ttheir\tenvironment.\tIn
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of\tthe\tnutrient\thistidine\tin\tthe\tgrowth\tmedium\tsilences\tthe\tgenes\tneeded\tfor\tits\tbiosynthesis.\n\tSince\nhistidine\tis\tan\tessential\tamino\tacid,\tthese\tgenes\tare\tnormally\texpressed\tconstitutively\t(always\t“on”).\nIn\tthis\tway\tthe\torganism\tconserves\tits\tenergy\tby\tsensing\tthe\tenvironment,\tdetecting\thistidine,
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silencing\tbiosynthesis,\tand\tmaking\tuse\tof\tthe\thistidine\tin\tthe\tenvironment.\nIn\tboth\tthe\tlactose\tand\thistidine\texamples,\tthere\tis\tcommunication\tbetween\tthe\tenvironment\tand\nthe\tDNA\tto\tsilence\tor\n\tactivate\tgenes,\tas\tappropriate\tto\tthe\thealth\tof\tthe\torganism.\tThe\tprocess\tof
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sensing\tand\tresponding\tto\tthe\texternal\tand\tinternal\tenvironments\tdiffers\tin\tcomplexity\tamong
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these\taspects\tcan\tbe\tinherited.\tThe\tprocess\tin\thigher\n\torganisms\tis\tcalled\t\nsignal\ttransduction\n\tand\nthere\tare\tmore\tsteps\tand\tmore\tplayers\tinvolved\tin\tthe\tprocess.\tFood\tcontains\tnumerous\tbioactive\nmolecules\tfrom\tplants\tand\tanimals\tthat\tplay\timportant\troles\tin\tregulating\tgene\texpression\tby
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serving\tas\t“sensors”\tof\tthe\texternal\tenvironment.\tAmong\tthese\tbioactives\tare\tfamiliar\tcompounds\nsuch\tas\tisoflavones\tfrom\tsoybeans,\tcurcumin\tfrom\tthe\tspice\tturmeric,\n\tglucosinolates\tfrom\ncruciferous\tvegetables,\tand\tepigallocatechin-3-gallate\tfrom\tgreen\ttea.\tFor\tadditional\tinformation\ton
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a\tsmall\tmolecular\tweight\tligand\tin\tanother\tregion.\tThe\tcomplex\tthen\tbinds\tto\tDNA\tand\tinfluences\ngene\texpression.\tIn\tthis\tway,\tfood-derived\tmolecules\t(often\treferred\tto\tas\t\nbioactive\tfood\ncomponents\n)\tand\tnonfood\tmolecules\tsuch\tas\ttoxic\tenvironmental\tchemicals\tcommunicate\twith\ngenes\tand\tinfluence\twhich\tones\tare\tswitched\ton\tor\n\toff,\tas\tneeded.
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genes\tand\tinfluence\twhich\tones\tare\tswitched\ton\tor\n\toff,\tas\tneeded.\nThese\tligands\tmay\tregulate\ttranscription\tof\tgenes\tneeded\tfor\ttheir\tmetabolism.\tAlternatively,\nthey\tmay\tcommunicate\ta\tbroader\tmessage,\tsuch\tas\tthe\tpresence\tof\tchronic\tinflammation\tand\tthe\nneed\tto\tdampen\tthe\texpression\tof\tgenes\tthat\tproduce\tproinflammatory\tcytokines.\tExamples\tof
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bioactive\tfood\tcomponents\tinclude\tthe\tomega-3\tfatty\tacids\tinvolved\tin\tsilencing\ttranscription\tof\nproinflammatory\n\tgenes,\tderivatives\tof\tvitamin\tA\tand\tvitamin\tD,\tand\tnumerous\tplant-derived\tsmall\nmolecular\tweight\tligands\t(phytonutrients).\tSee\t\nBox\t6.4\n\tfor\tfurther\tdiscussion\tof\tphytonutrients.
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Box\t6.4\n\tfor\tfurther\tdiscussion\tof\tphytonutrients.\nIn\thuman\tbeings\tthis\tprocess\tof\tsensing\tthe\tenvironment\tand\tcommunicating\twith\tDNA\tis\ta\nmore\tcomplex\tversion\tof\tthe\tability\tof\tlower\torganisms\tto\tsense\tnutrients\tin\tthe\tgrowth\tmedium\nand\tturn\ton\tor\toff\tthe\texpression\tof\n\tgenes\tneeded\tfor\tnutrient\tmetabolism.\tIn\thigher\torganisms
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genes\tneeded\tfor\tnutrient\tmetabolism.\tIn\thigher\torganisms\nthere\tare\tmore\tsteps\tand\tmore\tplayers\tinvolved\tin\tthe\tprocess\tbut\tthe\tbasic\ttheme\tis\tthe\tsame:\tto\nprotect\tthe\torganism\tby\tresponding\tappropriately\tto\tthe\tstate\tof\tthe\tever-changing\tenvironment.
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-0.1098274439573288, -0.032615967094898224, -0.02812492661178112, 0.04402900114655495, 0.10902795195579529, 0.028657883405685425, 0.011457163840532303, -0.04184180498123169, 0.07534706592559814, -0.03889777883887291, 0.0316508524119854, -0.07351818680763245, -0.05269790068268776, 0.023766595870256424, -0.0036217025481164455, -0.01661515235900879, 0.019923042505979538, 0.039450254291296005, 0.03141065686941147, -0.03748830780386925, -0.07446251064538956, -0.05298707261681557, 0.02607755735516548, -0.030993107706308365, 0.021517619490623474, -0.0017099149990826845, -0.0594988651573658, -0.14469845592975616, 0.059233974665403366, -0.013182738795876503, -0.01358485221862793, -0.005927564110606909, -0.03495090827345848, 0.003256293712183833, -0.034718193113803864, -0.05100567638874054, 0.051616303622722626, -0.04146881029009819, -0.013731228187680244, -0.041507117450237274, -0.019675828516483307, 0.10624364763498306, 0.10517663508653641, 0.024727966636419296, 0.0049881464801728725, 0.006637953221797943, -0.09179901331663132, 0.04400797188282013, 0.025729389861226082, -5.188068641359678e-8, 0.03644018992781639, 0.003932689782232046, 0.09261155128479004, 0.016880616545677185, 0.02080581896007061, 0.03019445762038231, 0.08211804181337357, 0.02408139407634735, 0.013726606033742428, 0.018090475350618362, 0.04172677919268608, 0.1265106499195099, -0.019012045115232468, 0.03545457124710083, 0.09076125919818878, 0.012068845331668854, -0.002700031967833638, 0.0644334927201271, -0.0035881251096725464, -0.042467352002859116, -0.007302781566977501, 0.04464759677648544, -0.03577233478426933, 0.0024371840991079807, -0.02320517972111702, -0.033947691321372986, -0.027545971795916557, -0.014079269021749496, 0.011701752431690693, 0.021362317726016045, 0.07377496361732483, -0.04501814767718315, -0.039747945964336395, -0.06569058448076248, -0.04455561190843582, 0.049743086099624634, 0.014079876244068146, -0.08194203674793243, 0.039800357073545456, 0.07548651099205017, 0.04183616489171982, 0.06054126098752022, -0.026959162205457687, 0.08883554488420486, 0.04393868148326874, -0.0721849575638771, 0.04724635183811188, 0.06870534271001816, -0.06475386023521423, -0.07569240778684616, -0.01110551506280899, 0.11714232712984085, -0.0010883525246754289, -0.04545881226658821, -0.04002046585083008, 0.020592065528035164, 0.06999646872282028, 0.07113469392061234, -0.026308968663215637, 0.007326815277338028, 0.06282947957515717, 0.06471668928861618, 0.09325531870126724, -0.02220454253256321 ]
If\tthe\tmolecule\tthat\ttriggers\tthe\tswitching\ton\t(or\toff)\tof\ta\tgene\tis\tfat-soluble\t(hydrophobic)\tand\tof\nsmall\tmolecular\tweight,\tit\ttypically\tcan\tpass\n\tthrough\tthe\tcellular\tand\tnuclear\tmembranes\tand\nbind\tto\tDNA\tthrough\tDNA-binding\ttranscription\tfactors.\tExamples\tinclude\tthe\tsteroid\thormones,
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vitamin\tA,\tvitamin\tD,\tand\tthyroid\thormones.\tIf\tthe\tmolecule\tis\tlarge\tor\twater-soluble\n(hydrophilic),\tit\twill\tnot\treadily\tpass\tthrough\tmembranes.\tInstead\tit\twill\tdock\twith\treceptors\ton\nthe\touter\tcell\tmembrane.\tDocking\tsets\toff\tthe\tprocess\tof\t\nsignal\ttransduction\n,\ta\tmultistep
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signal\ttransduction\n,\ta\tmultistep\ncascade\tthat\tamplifies\tthe\tinitial\tsignal\tand\tultimately\tresults\tin\tan\tactivator\tmolecule\tbinding\tto\na\ttranscription\tfactor\tthat\tin\tturn\tbinds\tto\tDNA\tand\tactivates\tor\tinhibits\texpression\tof\tthe\ttarget\ngene.\tNumerous\tfood-derived\tmolecules\tare\tinvolved\tin\tsignal\ttransduction.
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The\tnuclear\tfactor-κB\t(NF-κB)\tfamily\tof\ttranscription\tfactors\tprovides\tan\texample\tof\tsuch\ta\nsignal\ttransduction\n\tmodel\tof\tgene\tregulation\tin\thigher\torganisms.\tThese\ttranscription\tfactors\nregulate\tnumerous\tgenes\tinvolved\twith\tinflammation,\timmunity,\tcell\tproliferation\tand
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differentiation,\tand\tapoptosis\t(programmed\tcell\tdeath).\tThe\tNF-κB\tfactors\treside\tin\tthe\tcytoplasm\nand\tare\tkept\tinactive\tby\tthe\tbinding\tof\tinhibitors.\tWhen\ta\tsignal\tmolecule\tfrom\tthe\tenvironment\nconnects\tto\treceptors\ton\tthe\tcell\tsurface,\n\ta\tstepwise\tcascade\tis\tinitiated\tthat\tactivates\tthe\tNF-κB
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a\tstepwise\tcascade\tis\tinitiated\tthat\tactivates\tthe\tNF-κB\ntranscription\tfactors.\tThe\tactive\tfactors\tthen\ttranslocate\tto\tthe\tnucleus\tto\tbind\tto\tgenes\twhose\nexpression\tis\tunder\ttheir\tregulation.\nActivators\tof\tthis\tfamily\tof\ttranscription\tfactors\tare\tmolecules\tthat\tsound\tthe\talarm\tthat\tthe
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organism\tis\tunder\tattack,\tsuch\tas\ttissue\tnecrosis\tfactor\talpha\t(TNFα),\tinterleukin-1\t(IL-1),\tand\nreactive\toxygen\n\tspecies\t(free\tradicals).\tIn\tcontrast,\tseveral\tfood\tphytonutrients\thave\tbeen\tshown\nto\thelp\tmaintain\tthe\tinactive\tstate\tof\tNF-κB\tand\tprotect\tagainst\tinflammation.\tThese\tmolecules
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have\tbeen\tfound\tin\tthe\tcruciferous\tvegetables\t(indole-3-carbinol,\t3,3′-diindolylmethane),\tin\nsoybeans\t(genistein\tand\tother\tisoflavones),\tand\tin\tcurcumin,\tfrom\tthe\tspice\tturmeric.\nBOX\t6.4\nBioactive\tFood\tComponents:\n\t\nPhytonutrients\nFood\tcontains\tmany\tthousands\tof\tbiologically\tactive\tmolecules\t(referred\tto\tas\t“bioactive\tfood
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components”)\tthat\tare\tbeing\tinvestigated\tfor\ttheir\thealth\tbenefits.\tBioactives\tderived\tfrom\tplants\nare\tcalled\t“phytonutrients”\t(“phyto”\tin\tGreek\tmeaning\t“plants”).\tThe\toriginal\tterm\tfor\tthese\nbioactives\twas\t“phytochemicals”\tbut\twas\tchanged\tto\tphytonutrients\tbecause\texpressed\ndiscomfort
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discomfort\n\twith\tthe\tterm\t“chemicals.”\tAlthough\tnot\ttechnically\tnutrients,\tphytonutrients\tare\nemerging\tas\timportant\tmetabolic\tcomponents.\nFrom\ta\tdietary\tstandpoint,\tthe\tmost\tcommonly\tstudied\tphytonutrients\thave\tbeen\tthose\tfrom\nfruits,\tvegetables,\tlegumes,\tcereal\tgrains,\tnuts,\tseeds,\tteas,\tolive\toil,\twine,\therbs,\tspices,\tand\tdark\nchocolate\t(
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chocolate\t(\nUpadhyay\tand\tDixit,\t2015\n;\t\nAndreesu\tet\tal,\t2018\n).\tPhytonutrients\tregulate\n\tnumerous\ncellular\tand\tmolecular\tpathways,\tsuch\tas\tpreventing\tcell\tproliferation\tand\taggregation,\nprotecting\tagainst\tinflammation\tand\toxidative\tstress,\tpotentiating\tsignals\tfrom\tthe\tenvironment,
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and\tregulating\tgene\texpression\tin\tresponse\tto\tenvironmental\ttriggers.\tThe\tbenefits\tof\tthese\ncompounds\tare\tbeing\tinvestigated\tin\tmany\tprevalent\tchronic\tdisorders,\tsuch\tas\tcancer,\tvascular\ndisease\t(hypertension,\n\tdyslipidemia,\tsmooth\tmuscle\tproliferation\tleading\tto\tintimal\tthickening),
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diabetes\t(glucose\tintolerance,\tinsulin\tresistance),\tand\tneurodegeneration.\nPolyphenols\tare\tthe\tlargest\tcategory\tof\tphytonutrients\tand\tinclude\tsimple\tphenolic\tacids,\nstilbenes,\tcurcuminoids,\tchalcones,\tlignans,\tflavonoids,\tand\tisoflavones.\tCommon\tfood\tsources\tof\npolyphenols\tinclude\tgenistein\tand\tdaidzein\t(soy),\tresveratrol
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-0.021320847794413567, 0.0015134764835238457, -0.0612199567258358, 0.05923682451248169, 0.03301530331373215, -0.09281428903341293, 0.00405344320461154, 0.10188592970371246, 0.06062959134578705, -0.09331595152616501, -0.011726965196430683, 0.1060720682144165, -0.007857591845095158, -0.05678824335336685, -0.023052871227264404, 0.028921090066432953, 0.06776081770658493, 0.0067850928753614426, 0.0037636070046573877, -0.07976454496383667, 0.044233668595552444, 0.052108485251665115, 0.09961678087711334, 0.010291367769241333 ]
polyphenols\tinclude\tgenistein\tand\tdaidzein\t(soy),\tresveratrol\n\t(purple\tgrape\tskins,\tred\twine),\nquercetin\t(onions),\tcatechins\tand\tepicatechins\t(beans,\tgreen\ttea,\tblack\ttea,\tapricots,\tchocolate),\nproanthocyanidins\t(apples,\tcocoa,\tberries),\tand\tcurcumin\t(turmeric,\tmustard,\tcurries).\tCurcumin
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is\talso\tantiinflammatory\tand,\tas\tsuch,\tis\tpotentially\thelpful\tin\tvirtually\tall\tof\tthe\tchronic\tdisorders\nsince\tlow-grade\tchronic\tinflammation\tis\tan\tunderlying\tmechanism.\tGlucosinolates\n\tare\tsulfur-rich\ncompounds\tthat\toccur\tin\tcruciferous\tvegetables,\tsuch\tas\tbroccoli,\tcauliflower,\tBrussels\tsprouts,
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and\tkale.\tMetabolism\tof\tglucosinolates\tyields\tisothiocyanates\t(e.g.,\tsulforaphane)\tand\tindoles\n(e.g.,\tindole-3-carbinol),\twhich\thave\tbeen\tfound\tto\thave\tanticarcinogenic\tproperties\t(\nLampe\tand\nPeterson,\t2002\n;\t\nPeterson\tet\tal,\t2002\n).\tThe\tcruciferous\tvegetables\tand\ttheir\tglucosinolate\ncomponents
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).\tThe\tcruciferous\tvegetables\tand\ttheir\tglucosinolate\ncomponents\n\talso\tplay\tan\timportant\trole\tin\tbiotransformation,\twhich\tis\ta\tkey\tmechanism\tfor\nprotecting\tthe\tbody\tagainst\tcancer.\nOf\tthe\tpolyphenols,\tisoflavones,\tcurcumin,\tglucosinolates,\tresveratrol,\tand\tepigallocatechin-3-
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gallate\t(EGCG)\tfrom\tgreen\ttea\thave\tbeen\tof\tparticular\tinterest\tbecause\tthey\tare\tknown\tto\ninfluence\tgene\texpression\tthrough\tepigenetic\tmechanisms\t(\nVanden\tBerghe,\t2012\n).\tIsoflavones,\ncurcumin,\n\tand\tEGCG\tare\timportant\tinhibitors\tof\tthe\tproinflammatory\tNF-κB\tsignaling\tcascade.
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Resveratrol\tand\tcurcumin\tare\texamples\tof\tpolyphenols\tthat\tcan\tactivate\tSIRT1,\ta\thistone\ndeacetylase\tinvolved\tin\tinflammatory\tpathways,\tincluding\tNF-κB.\tThere\tare\tnumerous\tcell\nsignaling\tmechanisms\tinvolved\tin\tepigenetic\tregulation\tof\tgene\texpression;\tNF-κB\tis\tan\timportant\nexample\tbecause\tit\tregulates\tseveral\tproinflammatory
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example\tbecause\tit\tregulates\tseveral\tproinflammatory\n\tprocesses\tthat\tcontribute\tto\tchronic\ninflammation\tthat\tunderlies\tchronic\tdisorders.\tScientific\tresearch\tcontinues\tto\tsupport\tthe\nrecommendation\tfor\ta\tmostly\tplant-based\tdiet\tthat\tincludes\ta\twide\tvariety\tof\tfoods\tas\tessential\tto
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long-term\thealth.\tSeveral\toverviews\tof\tphytonutrients,\ttheir\thealth\tbenefits,\tand\ttheir\nmechanisms\tcan\tbe\tfound\tin\t\nRescigno\tet\tal,\t2018\n;\t\nLee\tet\tal,\t2018\n;\t\nRescigno\tet\tal,\t2017\n;\t\nUpadhyay\nand\tDixit,\t2015\n;\tand\t\nGupta\tand\tPrakash,\t2014\n.\nIn\taddition\tto\tthese\tmechanisms,\tnoncoding\tRNAs\tare\talso\tinvolved\tin\tregulating\tgene\texpression.
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0.0015153414569795132, -0.008790936321020126, -0.019935866817831993, 0.07879242300987244, 0.10300160199403763, -5.6885742338863565e-8, -0.007156228180974722, -0.0017158136470243335, -0.0057824114337563515, -0.009301514364778996, 0.04166597127914429, 0.0028106796089559793, 0.09327865391969681, 0.031629420816898346, 0.0107972277328372, -0.04023287445306778, 0.03402005136013031, 0.08041878044605255, -0.05860399827361107, -0.01524682343006134, 0.016857005655765533, -0.014438914135098457, -0.005335798487067223, 0.12009605020284653, -0.041367046535015106, -0.07476001232862473, 0.006047210190445185, 0.08475916087627411, -0.034444570541381836, -0.02113298326730728, -0.07145871967077255, -0.004403932951390743, -0.05962890386581421, 0.009092816151678562, -0.012221853248775005, -0.014803731814026833, -0.004722088575363159, -0.013861955143511295, -0.056739505380392075, -0.06734161078929901, -0.03857104480266571, 0.040224287658929825, -0.018004365265369415, -0.04357338324189186, 0.001507028704509139, 0.14978636801242828, 0.04044898971915245, 0.024689966812729836, 0.01564979739487171, 0.08491229265928268, 0.06513727456331253, -0.06762724369764328, -0.021066686138510704, 0.06637609004974365, 0.026499075815081596, -0.07894744724035263, -0.007823961786925793, 0.09812162816524506, 0.025473643094301224, -0.03969316929578781, -0.042318474501371384, 0.030922511592507362, 0.03699922934174538, 0.035938069224357605, -0.02287929877638817, 0.018524613231420517, 0.09499787539243698, 0.013468599878251553, 0.04953783378005028, 0.007782019674777985 ]
These\tRNAs\tare\tproduced\tduring\ttranscription\tbut\tare\tnot\tmRNA\tand\ttherefore\tdo\tnot\tdirect\tprotein\nsynthesis.\tThere\tare\tlong\tnoncoding\tRNAs\t(lncRNA)\tand\tshort\tnoncoding\tRNAs\t(sncRNA),\twhich\ninclude\tmicroRNAs\t(miRNA)\tand\tsmall\tnucleotide\tRNAs\n\t(snRNA).\tThe\tfinding\tthat\tthese\tRNAs\tare
[ -0.03269999846816063, -0.07113017141819, 0.0054059140384197235, -0.06412110477685928, -0.05554373562335968, 0.03782172501087189, -0.023378124460577965, 0.027807580307126045, -0.009315443225204945, 0.10631707310676575, 0.0784538984298706, -0.01229953020811081, -0.04474399611353874, 0.03211238980293274, -0.06399593502283096, 0.0660395398736, -0.11872761696577072, 0.0291011743247509, -0.01718844473361969, -0.00155759381595999, 0.044793423265218735, 0.13813500106334686, -0.012363283894956112, -0.015810495242476463, 0.03839720040559769, 0.0005381973460316658, 0.03325171023607254, -0.016118763014674187, 0.018051903694868088, -0.07348357886075974, -0.07541622966527939, 0.012733519077301025, 0.02682400494813919, -0.025881564244627953, 0.05015761777758598, 0.015367635525763035, -0.04641001299023628, 0.0011049724416807294, 0.10546322911977768, 0.05626910924911499, 0.04630086198449135, -0.044953301548957825, -0.03320937976241112, 0.04505451023578644, 0.06795193254947662, 0.01348443515598774, 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0.05652182549238205, 0.009063204750418663, -0.01837940886616707, -0.0372338593006134, -0.04639086499810219, 0.02921929955482483, -0.02811412326991558, 0.11218943446874619, -0.022024311125278473, 0.0575689971446991, -0.000826721137855202, 0.02396743930876255, 0.0027178952004760504, 0.030569951981306076, -0.20629799365997314, -0.06172831356525421, 0.04451862350106239, 0.03765127807855606, 0.010619736276566982, -0.019545691087841988, 0.06633922457695007, 0.00004596865619532764, 0.01288463082164526, -0.007386388722807169, -0.00846394058316946, -0.04530143737792969, -0.0466272197663784, 0.01296343095600605, -0.05264098197221756, -0.03884255141019821, -0.09042991697788239, -0.03856593370437622, -0.056263770908117294, -0.0368150919675827, 0.0095340795814991, -0.0965849980711937, -0.038117680698633194, 0.023974766954779625, 0.006423348095268011, 0.031264420598745346, -0.005141959059983492, -0.08732578903436661, -0.05222577229142189, -3.4841880310403074e-33, -0.003917895257472992, -0.021117648109793663, -0.018227463588118553, -0.061314214020967484, -0.06830212473869324, 0.014885648153722286, 0.03602113947272301, -0.05706346035003662, 0.012906590476632118, -0.05903880298137665, 0.07562674582004547, 0.0228138230741024, -0.047467902302742004, -0.12035846710205078, -0.03615308180451393, -0.006605240050703287, 0.047018863260746, 0.05266950652003288, 0.009361625649034977, -0.005881644785404205, -0.055924613028764725, 0.08223890513181686, -0.07682029157876968, 0.08064043521881104, 0.052031032741069794, 0.026819592341780663, 0.017783788964152336, 0.06332627683877945, 0.035030797123909, 0.07263105362653732, 0.039096899330616, -0.06178855895996094, -0.0052254521287977695, 0.07991177588701248, -0.059337783604860306, 0.008825116790831089, 0.06042049452662468, -0.013027548789978027, -0.006878681480884552, -0.04563556984066963, 0.021523956209421158, 0.015127737075090408, 0.03783392906188965, 0.021337568759918213, 0.03696294501423836, -0.004599303472787142, 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-0.003153936006128788, 0.015023401938378811, -0.05959440767765045, 0.04148298129439354, 0.025176413357257843, -0.04908205196261406, -0.032933782786130905, 0.10670305788516998, -0.027793316170573235, -0.06590930372476578, 0.034678924828767776, 0.03404873237013817, -0.0023806910030543804, -0.06486304849386215, -0.07874738425016403, 0.053867511451244354, 0.0003202032239641994, 0.021709619089961052, -0.01737629808485508, 0.014834419824182987, 0.04242806136608124, 0.04947299510240555, 0.08756507188081741, -0.022058699280023575 ]
(snRNA).\tThe\tfinding\tthat\tthese\tRNAs\tare\nnot\tsimply\textra\tnucleotides\tthat\twere\tremoved\tduring\tmaturation\tof\tpre-mRNA\tinto\tmRNA\tis\tfairly\nrecent.\tThe\troles\tof\tthese\tvarious\tRNAs\tare\tbeing\tinvestigated\tand\tinclude\tgene\tsilencing\tas\ta\tmajor\ntarget\t(\nMattick,\t2018\n).\tSeveral\tthousand\tearly-stage\tstudies\tin\tmouse\tmodels\tand\thuman\ttissues
[ -0.028800569474697113, -0.08427894860506058, 0.01402341853827238, -0.04940233752131462, -0.07547719776630402, 0.04386157542467117, 0.004279776010662317, 0.007226869463920593, -0.02942725084722042, 0.08311882615089417, 0.10486197471618652, -0.024602316319942474, -0.023190584033727646, 0.008391362614929676, -0.04480743035674095, 0.09745541960000992, -0.08468042314052582, 0.009039524011313915, -0.013020635582506657, -0.033412329852581024, 0.025761472061276436, 0.13502033054828644, 0.05575893819332123, -0.021090514957904816, 0.020583361387252808, 0.007793887052685022, -0.018466690555214882, 0.012133825570344925, 0.02285703644156456, -0.07716493308544159, -0.07704633474349976, 0.06138337031006813, 0.051184818148612976, 0.007624311838299036, 0.04725368693470955, 0.021464373916387558, -0.0716453343629837, 0.012151292525231838, 0.13680563867092133, 0.04896927624940872, 0.05241183191537857, -0.07614751160144806, -0.04700490087270737, 0.03229052573442459, 0.04484959691762924, 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have\tbeen\treported.\tBoth\tlong\tand\tshort\tRNAs\thave\tbeen\tlinked\n\tto\tvarious\tmetabolic\tdisorders:\ndiabetes,\tobesity,\tcardiovascular\tdisease,\tcardiometabolic\tsyndrome,\tneurologic\tdisorders,\nnonalcoholic\tfatty\tliver\tdisease,\tand\tvarious\tcancers.\nEpigenomics\tand\tgene\texpression
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Epigenomics\tand\tgene\texpression\nThe\tregulation\tof\tgene\texpression\toccurs\tat\ttwo\tlevels:\tgenomic\tand\tepigenomic.\t“Epi”\tin\tGreek\nmeans\t“above,”\tas\tin\t“above”\tthe\tgenetic\tcode.\tGenomic\tcontrol\ttakes\tplace\twithin\tthe\tregulatory\nregion\tof\tgenes,\tupstream\tfrom\tthe\tpromoters.\t\nEpigenetics\n\tand\t\nepigenomics\n\trelate\tto\tprocesses
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Epigenetics\n\tand\t\nepigenomics\n\trelate\tto\tprocesses\nthat\talter\tgene\texpression\tthrough\tmodification\tof\thistone\tproteins\tor\tDNA\twithout\tchanging\tthe\nsequence\tof\tthe\tDNA,\tthereby\tkeeping\tthe\tinformation\tin\tDNA\tintact.\tThis\tpoint\tis\timportant\tsince\nDNA\tencodes\tthe\tinformation\tfor\tmaking\tRNAs\tand\tproteins,\twhich\tare\tcritical\tfor\tthe\ttranslation\tof
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this\tinformation\n\tinto\tan\toperating\tsystem\tthat\tgenerates\thuman\tfunction.\t\nEpigenetics\n\tis\tconcerned\nwith\tthe\tprocesses\tinvolved\tin\tregulating\tgene\texpression,\thow\tgenes\tare\tturned\ton\tor\toff\tand\tthe\nmechanisms\tinvolved.\tThese\tprocesses\tare\tparticularly\tcritical\tduring\tthe\tvarious\tstages\tof\tnormal\nhuman\tgrowth\tand\tdevelopment.\t\nEpigenomics
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human\tgrowth\tand\tdevelopment.\t\nEpigenomics\n,\tin\tcontrast,\tis\tthe\tcollective\tset\tof\tepigenetic\ttags\tin\na\tgenome.\tAlthough\n\tthe\tDNA\tsequence\tis\tthe\tsame\tfrom\tcell\tto\tcell,\tthe\tpattern\tof\tgene\texpression\nis\tdifferent\tamong\tdifferent\tcell\ttypes\tand\tthese\tpatterns\tcan\tbe\tinherited.\tThe\tpattern\tof\nepigenetic\tmarks
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epigenetic\tmarks\n\t(or\t“tags”)\tthat\tare\tcharacteristic\tof\teach\tcell\ttype\tdetermines\tthe\tgene\nexpression\tpattern\t(i.e.,\twhich\tgenes\tare\tactive\tor\tsilent\tat\tany\tgiven\tpoint).\tEpigenetic\tmarks\nrepresent\tan\tadditional\tset\tof\tinstructions\n\tbeyond\tthe\tDNA\t\ngenetic\tcode\n\tthat\tgoverns\tthe\tprocess
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beyond\tthe\tDNA\t\ngenetic\tcode\n\tthat\tgoverns\tthe\tprocess\nof\tdecoding\tDNA\tinto\tRNA\tand\tprotein.\tEpigenomic\tresearch\tfocuses\ton\tunderstanding\twhich\nepigenetic\tmarks\tare\twithin\ta\tgenome,\thow\tchanges\tarise,\tthe\tinfluence\tof\tepigenetic\tpatterns\ton\nphysiologic\tfunction,\tand\thow\tthe\tmarks\tare\tinherited.
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0.03816916048526764, 0.04385533183813095, -0.047664858400821686, 0.0755341425538063, 0.05322270840406418, -0.0702567920088768, -0.026551568880677223, 0.08356796205043793, -0.022233299911022186, -0.06176740303635597, 0.029802868142724037, 0.1313590258359909, -0.011643998324871063, -0.01662098430097103, -0.02411051094532013, 0.0300372876226902, 0.055965449661016464, 0.05960257723927498, -0.04155275970697403, 0.006759207230061293, 0.0994720607995987, 0.05949527770280838, 0.09781903028488159, -0.03458041325211525 ]
physiologic\tfunction,\tand\thow\tthe\tmarks\tare\tinherited.\nEpigenetic\tgene\tregulation\tis\tachieved\tthrough\tthe\taddition\tor\tdeletion\tof\tchemical\tgroups\tto\nhistone\n\tproteins\tor\tmethyl\tgroups\tto\tDNA.\tTo\tdate,\tthe\tmore\tcommon\ttags\tare\tacetyl\tgroups\tadded\nto\thistone\tproteins\tand\tmethyl\tgroups\tto\tDNA\tbut\tphosphorylation,\tubiquitylation,\tand\tsumoylation
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experiences\tthat\tled\tto\tthe\tepigenetic\tpatterns\tin\tthe\tegg\tand\tsperm.\tResearch\tand\tadvances\tin\ntechnology\twill\tlikely\texpand\tthe\tlibrary\tof\tpotential\tepigenetic\ttags\tas\twell\tas\tour\tunderstanding\tof\nepigenetic\tinheritance.\nIdentical\t(monozygotic)\ttwins\tare\ta\tnatural\texample\tof\tthe\tinfluence\tof\tepigenetics\tin\thuman\nbeings.
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beings.\n\tThe\ttwins\tare\tnot\tidentical\tphenotypically\tdespite\thaving\tidentical\tgenotypes.\tEpigenetic\nregulation\tof\tgene\texpression\tcontributes\tto\tthis\tphenomenon,\twhich\tis\tcalled\tmonozygotic\ndiscordance\t(also\tepigenetic\tdrift).\tSee\t\nBox\t6.5\n\tfor\ta\tfurther\texploration\tof\tthe\trole\tof\tepigenetics\tin
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0.08575619012117386, 0.03574296459555626, -0.0584334172308445, 0.05522379279136658, 0.04781992733478546, -0.057336628437042236, 0.0024580988101661205, 0.057743191719055176, 0.001947332639247179, 0.003379487432539463, -0.01981649547815323, 0.1215905174612999, -0.014746933244168758, -0.08126897364854813, -0.03220828250050545, -0.010100988671183586, 0.003440981497988105, 0.07087008655071259, -0.013626599684357643, 0.005380359478294849, 0.11466232687234879, 0.04091692343354225, 0.0978177860379219, -0.017228303477168083 ]
the\tdifferences\tin\tanthropomorphic\tfeatures\tand\tdisease\tsusceptibility\tas\tmonozygotic\ttwins\tage.\nBOX\t6.5\nEpigenetics\n\t\nand\tIdentical\tTwins\nHave\tyou\tever\twondered\twhy\tmost\tidentical\ttwins\tand\tother\tmonozygotic\tmultiples\thave\nincreasingly\tobvious\tphenotypic\tdifferences\tas\tthey\tage\tin\tspite\tof\thaving\tthe\tsame\tDNA?
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0.022231267765164375, 0.0026055118069052696, 0.059402164071798325, 0.06340011209249496, -3.9407002105917854e-8, 0.029829252511262894, -0.009046108461916447, 0.02723056636750698, -0.021520063281059265, 0.014810781925916672, -0.005362388212233782, 0.05385768041014671, 0.017009709030389786, -0.03713281825184822, -0.058812953531742096, 0.026818811893463135, 0.0806451067328453, -0.07941465824842453, -0.0261981263756752, 0.1078624352812767, 0.009999524801969528, -0.012148692272603512, 0.054688744246959686, -0.010452806949615479, 0.006924821063876152, 0.0012058360734954476, 0.06022535264492035, -0.05679319053888321, -0.019736113026738167, -0.05959422513842583, 0.007682128343731165, -0.048581041395664215, -0.0335795059800148, -0.022969452664256096, 0.004240269307047129, 0.03811527043581009, -0.01175802480429411, -0.0405874028801918, -0.040920913219451904, -0.021034639328718185, 0.03227613866329193, -0.08678290247917175, -0.04286675527691841, -0.002655046060681343, 0.08011109381914139, 0.0508551150560379, 0.0059259491972625256, -0.03333469107747078, 0.060537878423929214, 0.1076044887304306, -0.04085259139537811, 0.016692649573087692, 0.062230952084064484, -0.010616942308843136, -0.038223523646593094, -0.027399325743317604, 0.09741738438606262, -0.029784120619297028, -0.02674710378050804, -0.04812680929899216, 0.03710165619850159, 0.03148922696709633, 0.05320669338107109, -0.056866079568862915, -0.00028400059090927243, 0.0954342782497406, 0.07133712619543076, 0.09667836129665375, -0.012516737915575504 ]
Commonly\tencountered\tdifferences\tinclude\tphysical\tfeatures,\tdisease\tsusceptibility,\tand\npersonality.\tTwins\treared\tapart\ttend\tto\texhibit\tgreater\tobservable\tdifferences.\tHowever,\tnot\tall\nmonozygotic\ttwins\n\texhibit\tthis\tpattern.\tThe\tbasis\tfor\tthese\tdifferences\tlies,\tat\tleast\tin\tpart,\twith
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different\tepigenetic\tsignatures,\twhich\tleads\tto\tdifferential\tregulation\tof\tgene\texpression\tand\tthe\nphenomenon\tof\t“monozygotic\tdiscordance,”\talso\tcalled\t“epigenetic\tdrift.”\tEarly\tinvestigations\tby\nFraga\tand\tcolleagues\t(\nFraga\tet\tal,\t2005\n;\t\nPoulsen\tet\tal,\t2007\n)\tfound\tthat\tmonozygotic\t(MZ)\ttwins\nwere\tidentical\tin\ttheir
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)\tfound\tthat\tmonozygotic\t(MZ)\ttwins\nwere\tidentical\tin\ttheir\n\tepigenetic\tpatterns\tearly\tin\tlife\tbut\tthat\tthe\tepigenetic\tpatterns\tof\tDNA\nmethylation\tand\thistone\tacetylation\tin\tolder\tMZ\ttwins\twas\tconsiderably\tdifferent.\tThese\tstudies\nwere\tsignificant\tin\texplaining\thow\tdifferent\tphenotypes\tcould\tarise\tfrom\tapparently\tidentical\ngenotypes.
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0.09318886697292328, 0.04543641209602356, 0.019344937056303024, -0.03687575086951256, 0.06338426470756531, 0.05286224186420441, -0.07444950193166733, 0.030219614505767822, 0.050241619348526, -0.0006402707658708096, -0.014529366046190262, 0.027241704985499382, 0.12260323762893677, -0.01768573746085167, -0.02280646190047264, -0.06708626449108124, 0.04477464780211449, 0.07531233876943588, 0.08831046521663666, -0.008341914042830467, 0.0010899767512455583, 0.09131819009780884, 0.05954346805810928, 0.08731166273355484, -0.021456604823470116 ]
genotypes.\nRecently\tthe\tsituation\thas\tgrown\teven\tmore\tcomplex.\tWaterland\tand\tcolleagues\tdiscovered\tthat\nthe\ttiming\tof\tthe\trestoration\n\tof\tthe\tepigenetic\tmarks\tin\tmonozygotic\ttwins\tdetermines\thow\tsimilar\nthe\tmarks\tare\tbetween\tthe\ttwins\t(\nVan\tBaak\tet\tal,\t2018\n).\tThese\tmarks\tare\terased\tduring
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Van\tBaak\tet\tal,\t2018\n).\tThese\tmarks\tare\terased\tduring\nfertilization\tand\trestored\tduring\tvery\tearly\tembryonic\tdevelopment.\tMonozygotic\tsiblings\tform\nwhen\tthe\tvery\tearly\tembryo\tsplits\tin\ttwo\tand\teach\tembryo\tdevelops\tinto\ta\tseparate\tindividual.\tIf\nthe\tepigenetic\tmarks\tare\treset\tbefore\tthe\tembryo\tsplits,\n\tthe\tepigenetic\tpattern\twill\tbe\tthe\tsame
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the\tepigenetic\tpattern\twill\tbe\tthe\tsame\nfor\tboth\ttwins,\tcalled\t“epigenetic\tsupersimilarity”.\tIf\tthe\tmarks\tare\treset\tafter\tthe\tembryo\tsplits,\nthere\twill\tbe\tdifferences\tin\tepigenetic\tpatterns\tbetween\tthe\ttwins.\tIn\tboth\tcases\tthe\tDNA\nsequence\tis\tidentical,\tbut\tthe\tepigenetic\tpattern\tis\tidentical\tor\tdifferent\tdepending\ton\tthe\ttiming
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of\tresetting\tthe\tepigenetic\tmarks.\nTwo\tfindings\tfrom\tthis\tstudy\n\tare\tintriguing\tand\tunder\tfurther\tstudy.\tOne\tis\tthe\tlink\tbetween\tthe\ngenes\tinvolved\tin\tepigenetic\tsupersimilarity\tand\tthe\tdevelopment\tof\tcancer.\tThe\tother\tis\ta\nrethinking\tof\tthe\tuse\tof\tmonozygotic\ttwins\tas\ta\tmodel\tsystem\tfor\testimating\tthe\trisk\tof\tdisease
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contributed\tby\tgenes\tvs.\tenvironment.\tThe\tlack\tof\tstratification\tof\tthe\ttwins\tin\tsuch\tstudies\tbased\non\ttheir\tepigenetic\tpattern\tat\tbirth\tmay\thave\n\tled\tto\tan\toverestimation\tof\tgenetic\tcontribution\tto\ndisease.\nEpigenetic\tmarks\tprovide\tthe\tinstructions\tfor\tthe\tdevelopment\tand\tdifferentiation\tof\teach\tcell\ttype
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0.040225524455308914, 0.0006096267607063055, 0.09137643873691559, 0.09561167657375336, -0.018519148230552673, -0.05782543867826462, 0.048366617411375046, 0.00926138088107109, -0.1054801270365715, -0.007607455365359783, 0.05473009869456291, -0.02444968745112419, -0.037760257720947266, -0.06120665371417999, -0.0044723255559802055, 0.09097116440534592, 0.05616619437932968, 0.03196219727396965, -0.0365617536008358, 0.06983663141727448, 0.13034233450889587, 0.08048023283481598, 0.0005787038244307041 ]
and\tfor\tdirecting\ttheir\taggregation\tinto\ttissues\tand\torgans.\tWith\tthe\texception\tof\tred\tblood\tcells,\nwhich\thave\tno\tnucleus,\teach\tof\tthe\tcells\tin\thigher\torganisms\tcontains\tthe\tfull\tset\tof\tDNA\tin\tthe\nnucleus.\tDuring\tdevelopment,\tthese\n\tcells\tdifferentiate\tinto\tthe\tvarious\ttypes\tof\tcells\tneeded\tto
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cells\tdifferentiate\tinto\tthe\tvarious\ttypes\tof\tcells\tneeded\tto\noperate\tthe\torganism,\tsuch\tas\teye\tcells,\tbone\tcells,\tliver\tcells,\theart\tcells,\tand\tso\ton.\tEach\tcell\ttype\nis\tspecialized\tfor\tparticular\ttasks,\twhich\trequires\tthat\tcertain\tof\tits\tgenes\tbe\ttranscribed\tand\tothers
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be\tsilenced.\tThe\timportance\tof\tnutrition\tduring\tthe\tprenatal\tand\tpostnatal\tdevelopmental\tperiods\ncannot\tbe\toveremphasized\tbecause\n\tthe\tdiet\tis\tthe\tsource\tnot\tonly\tof\tthe\tnutrients\tneeded\tfor\tgrowth\nbut\tfor\tthe\tepigenetic\tmarks\tthat\tdirect\tgrowth,\tdevelopment,\tand\tdifferentiation.\tResearch\tsuggests
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that\tmany\tother\tstressors\tin\taddition\tto\tfood\tinsufficiency\thave\tan\tepigenetic\teffect,\tsuch\tas\tpoverty,\nstress,\tand\ttoxic\texposure.\tA\tnew\tdiscipline,\tsocial\tepigenomics,\thas\tarisen\tthat\tfocuses\ton\tsocial\nexperiences\tthroughout\tthe\n\tlifespan\tand\tinvestigation\tof\tthe\tkey\tenvironmental\ttriggers\tand\ttheir\nepigenetic\teffects.\tSee\t\nBox\t6.6
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epigenetic\teffects.\tSee\t\nBox\t6.6\n\tfor\tadditional\tinformation.\nBOX\t6.6\nSocial\tEpigenomics\nSocial\tepigenomics\tis\tconcerned\twith\tthe\tnegative\tand\tpositive\tinfluences\tof\tsocial\texperiences\nthroughout\tthe\tlifespan.\tThese\texperiences\tdo\tnot\talter\tthe\tDNA\tsequence,\tonly\tthe\tepigenetic\nmarks\tattached\tto\tthe\tDNA\tand\thistone\tproteins.
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marks\tattached\tto\tthe\tDNA\tand\thistone\tproteins.\n\tThe\tepigenetic\tpattern\t(epigenome),\tin\tturn,\nalters\tgene\texpression.\tThis\tfeature\tis\timportant\tbecause\tgenes\tthat\tmight\tnormally\tprotect\nagainst\ta\tdisease\t(such\tas\tcancer\ttumor-suppressor\tgenes)\tmay\tbe\tturned\toff\tand\tgenes\tthat\npromote\tdisease\t(such\tas\tcancer\toncogenes)\tmay\tbe\tturned\ton.
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promote\tdisease\t(such\tas\tcancer\toncogenes)\tmay\tbe\tturned\ton.\nThe\tfocus\tof\tresearch\tin\tthis\tarea\tis\tto\tinvestigate\tthe\tkey\tenvironmental\tdrivers\tfor\taltering\tthe\nepigenetic\n\tpattern\tand\ttheir\tinfluences\ton\tfunction.\tNumerous\tfactors\tare\tbeing\tfound\tto\tcause\nchanges\tin\tthe\tepigenetic\tpattern,\tfrom\tfood\tto\tstress\tto\ttoxic\tchemicals\tto\taging.\tThe
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encouraging\taspect\tof\tthis\twork\tis\tthat\tthese\tinfluencers\ton\tepigenetic\tpatterns\tare\tpotentially\nmodifiable.\tResearch\tis\tidentifying\twhat\tthe\tenvironmental\ttriggers\tare\tand\tthe\tmechanisms\tby\nwhich\tthey\tinfluence\tgene\texpression.\nSince\t2008\tthe\tNational\tInstitutes\ton\tMinority\tHealth\tand\tHealth\tDisparities\thas\testablished\ta
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program\tfor\tfunding\tresearch\thighlighting\tsocial\tepigenomics,\tparticularly\tas\tit\tincludes\tthe\nhealth\tof\tminorities\tand\thealth\tdisparities\tin\tthe\tU.S.\tpopulation,\tespecially\tas\ta\tresult\tof\tracism\nand\tdiscrimination.\tThe\texpectation\tis\tthat,\tby\tidentifying\tepigenetic\tmodifications,\tit\tmay\tbe\npossible\tto
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possible\tto\n\tdetect\tdisease\tsusceptibilities\tearly\tand\ttailor\tinterventions\tthat\tcan\tprevent\tchronic\nconditions\tfrom\tmanifesting.\tSee\tthe\tNational\tInstitutes\tof\tHealth\twebsite\ton\tresearch\ton\tsocial\nepigenomics\tto\taddress\thealth\tdisparities\tfor\tinformation\ton\tthe\ttypes\tof\tresearch\tstudies\tthat\tare\nbeing\tconducted.
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Modes\tof\tinheritance\nThree\tprocesses\tinfluence\thow\ttraits\tare\ttransmitted\tfrom\tone\tgeneration\n\tto\tthe\tnext:\tmendelian\ninheritance,\tmitochondrial\tinheritance,\tand\tepigenetic\tinheritance.\nMendelian\tinheritance\nEach\tcell’s\tnucleus\tcontains\ta\tcomplete\tset\tof\tgenetic\tmaterial\t(genome),\tdivided\tamong\t22\tpairs\tof
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