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BOX\t5.6\nPhysical\tActivity\tAssessment\tQuestionnaire\nTo\tbe\tconsidered\tphysically\n\tactive,\tyou\tmust\tget\tat\tleast:\n•\t\n30\tminutes\tof\tmoderate\tphysical\tactivity\ton\t5\tor\tmore\tdays\ta\tweek,\tOR\n•\t\n20\tminutes\tof\tvigorous\tphysical\tactivity\ton\t3\tor\tmore\tdays\ta\tweek\nHow\tphysically\tactive\tdo\tyou\tplan\tto\tbe\tover\tthe\tnext\t6\tmonths?\t\n(Choose\tthe\tbest\tanswer.) | [
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(Choose\tthe\tbest\tanswer.)\n____\tI\tam\tnot\tcurrently\tactive\tand\tdo\tnot\tplan\tto\tbecome\tphysically\tactive\tin\tthe\tnext\t6\nmonths.\n____\tI\tam\tthinking\tabout\tbecoming\n\tmore\tphysically\tactive.\n____\tI\tintend\tto\tbecome\tmore\tphysically\tactive\tin\tthe\tnext\t6\tmonths.\n____\tI\thave\tbeen\ttrying\tto\tget\tmore\tphysical\tactivity. | [
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____\tI\thave\tbeen\ttrying\tto\tget\tmore\tphysical\tactivity.\n____\tI\tam\tcurrently\tphysically\tactive\tand\thave\tbeen\tfor\tthe\tlast\t1-5\tmonths.\n____\tI\thave\tbeen\tregularly\tphysically\tactive\tfor\tthe\tpast\t6\tmonths\tor\tmore.\nCompared\twith\thow\tphysically\tactive\tyou\thave\tbeen\tover\tthe\tlast\t3\tmonths,\thow\twould\tyou\ndescribe\n\tthe\tlast\t7\tdays:\t\n(Check\tone) | [
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describe\n\tthe\tlast\t7\tdays:\t\n(Check\tone)\n______\tMore\tactive______\tLess\tactive______\tAbout\tthe\tsame\nRecall\tyour\tparticipation\tin\tactivities\tor\tin\tsedentary\tbehaviors,\tover\tthe\tpast\t24\thours:\n•\t\nReading,\twatching\tTV,\tor\tcomputer\ttime\t_____\tminutes/day\n•\t\nFast\twalking\t____\tminutes/day\n• | [
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•\t\nFast\twalking\t____\tminutes/day\n•\t\nPhysical\tactivity\t(swimming,\ttennis,\tracquetball,\tsimilar)\t______\tminutes/day\n•\t\nOther\tphysical\tactivity\t(describe\n\t_________________)\t_______\tminutes/day\nWhat\tare\tthe\t3\tmost\timportant\treasons\twhy\tyou\twould\tconsider\tincreasing\tyour\tphysical\nactivity?\n▫\tImprove\tmy\thealth\t▫\tControl\tmy\tweight\t▫\tLower\tmy\tstress | [
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activity?\n▫\tImprove\tmy\thealth\t▫\tControl\tmy\tweight\t▫\tLower\tmy\tstress\nMeasures\tof\tstrength\nWith\taging,\tthe\tbalanced\tcycle\tof\tmuscle\tsynthesis\tand\tdegradation\tshifts\ttoward\tmore\tbreakdown\nthan\tsynthesis\tof\tmuscle\ttissue\t(see\t\nChapter\t19\n).\tThe\tconsequence\n\tis\tatrophy\tof\tmuscle\tmass\tand | [
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Chapter\t19\n).\tThe\tconsequence\n\tis\tatrophy\tof\tmuscle\tmass\tand\nloss\tof\tstrength\tand\tpower.\tHandgrip\tdynamometry\tcan\tprovide\ta\tbaseline\tnutritional\tassessment\tof\nmuscle\tfunction\tby\tmeasuring\tgrip\tstrength\tand\tendurance\tand\tis\tuseful\tin\tserial\tmeasurements.\nMeasurements\tof\thandgrip\tdynamometry\tare\tcompared\twith\treference\tstandards\tprovided\tby\tthe | [
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] |
acknowledges\tthe\tweb-like\tinterconnectedness\tof\tinternal\nphysiologic\tfactors\tand\tidentifies\troot\tcauses\tof\tchronic\tdisease\tby\tintegrating\ttraditional\tdietetic\npractice\n\twith\tnutritional\tgenomics\t(see\t\nChapter\t6\n),\tthe\trestoration\tof\tgastrointestinal\tfunction,\tthe | [
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] |
quelling\tof\tchronic\tinflammation\t(see\t\nChapter\t7\n),\tand\tthe\tinterpretation\tof\tnutritional\tbiomarkers.\nThe\tfunctional\tnutrition\tpractitioner\torganizes\tthe\tdata\tcollected\tfrom\ta\tdetailed\tintake\tthat\tincludes\nexploration\tof\tcore\tareas\tof\timbalance:\tdietary,\thormonal,\toxidative\tstress,\tenvironmental\texposures, | [
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immune\tfunction,\tand\tpsychological\tand\tspiritual\thealth.\tThis\tleads\ta\tunique\tand\tpersonalized\nassessment\tof\tdisease\tfor\teach\tindividual\twithin\tthe\tframework\tof\tthe\tNCP\t(see\t\nTable\t5.10\n,\t\nFig.\t5.9\n,\nand\t\nChapter\t11\n).\nFIG.\t5.9\nFunctional\tMedicine\tMatrix\tModel.\nTABLE\t5.10\nSelected\tComponents\tof\tFunctional\tNutrition\tAssessment\nIngestion\nDigestion | [
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Ingestion\nDigestion\nUtilization—Cellular\tand\nMolecular\tFunctional\nRelationships\nFood,\tfiber,\twater,\tsupplements,\tmedication\nAdequate\tmicroflora\nAntioxidants:\twater-soluble\nvitamin\tC,\tphytonutrients\nIntake\tpatterns\taffected\tby\temotional\tor\ndisordered\teating\nAllergies\nMethylation\tand\tacetylation:\ndependence\ton\tadequate\tB\ncomplex\tvitamins\tand | [
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dependence\ton\tadequate\tB\ncomplex\tvitamins\tand\nminerals\nToxins\tentering\tthe\tbody\tvia\tfood,\tskin,\ninhalants,\twater,\tenvironment\t(including\npesticides\tand\tchemicals)\nGenetic\tenzyme\ndeficits\nOils\tand\tfatty\tacids:\nprostaglandin\tbalance,\tcell\nmembrane\tfunction,\tvitamin\nE\tfunction\nHydration\nProtein\tmetabolism:\tconnective\ntissue,\tenzymes,\timmune | [
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Hydration\nProtein\tmetabolism:\tconnective\ntissue,\tenzymes,\timmune\nfunction,\tetc.\nInfection/inflammatory\nresponse\nVitamin\tD\tin\tconcert\twith\nfunctional\tmetabolic\tpartner\nnutrients\tvitamins\tA\tand\tK\nLifestyle:\tsleep,\nexercise,\tstressors\nCLINICAL\tCASE\tSTUDY\nGia,\ta\t58-year-old\tF,\tis\tadmitted\tto\tCity\tHospital\tfollowing\ta\twork-related\taccident.\tShe\thas\ta | [
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expression\tgenome-wide\tassociation\tstudies\t(eGWAS)\nexon\ngene,\tgenetics\ngene\tvariant/genetic\n\tvariation\nGenetic\tInformation\tNondiscrimination\tAct\t(GINA)\ngenome,\tgenomics\ngenome-wide\tassociation\tstudy\t(GWAS)\ngenomic\timprinting\ngenotype\nheterozygous\nhistone\nhomozygous\nintervening\tsequences\nintron\nkaryotype\nligand\nmendelian\tinheritance | [
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is\tnot\tonly\tto\tmanage\tchronic\tdisease\tmore\neffectively\tbut\talso\tto\trestore\thealth\tand,\tultimately,\tto\tprevent\tchronic\tdisease\tfrom\tdeveloping.\tThe\ninteractions\tamong\tgenes,\tdiet\tand\tother\tlifestyle\tfactors,\tand\ttheir\tinfluence\ton\thealth\tand\tdisease\nare\tthe\tfocus\tof\tnutritional\tgenomics.\nGenetic\tand\tgenomic\tfundamentals\nGenetics | [
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Genetic\tand\tgenomic\tfundamentals\nGenetics\n\tis\tthe\tscience\tof\theredity.\tIt\tis\tthe\tstudy\tof\tindividual\tgenes\n\tand\ttheir\tvariations,\thow\tthey\ngive\trise\tto\tmeasurable\ttraits\tand\tthe\tmechanisms\tby\twhich\ttraits\t(genes)\tare\tinherited\tfrom\tone\ngeneration\tto\tthe\tnext.\t\nGenomics\n\tfocuses\ton\tthe\tfull\tset\tof\tan\torganism’s\tgenes,\tits\t\ngenome\n,\tand | [
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The\tHuman\tGenome\tProject\twas\ta\tmultinational\tcollaboration\tformed\tto\tidentify\teach\tof\tthe\napproximately\t3\tbillion\tnucleotide\tbuilding\tblocks\tof\tthe\thuman\tgenome.\tSee\t\nBox\t6.1\n\tfor\tbackground\ninformation\ton\tthe\timportance\tof\tthis\tproject\tto\tthe\tprogress\tof\tunderstanding\tthe\tinterconnections\namong\tgenes,\tenvironment,\tand\thealth.\nBOX\t6.1 | [
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among\tgenes,\tenvironment,\tand\thealth.\nBOX\t6.1\nThe\tHuman\tGenome\tProject\nThe\tHuman\tGenome\tProject\t(HGP)\thas\tbeen\tthe\timpetus\tfor\ta\tfundamental\tshift\tto\tintegrating\ngenetic\tprinciples\tinto\thealth\n\tcare.\tThis\tambitious\tproject\twas\ta\t$15\tbillion\tinternational\teffort | [
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care.\tThis\tambitious\tproject\twas\ta\t$15\tbillion\tinternational\teffort\nthat\tbegan\tin\t1990,\theadquartered\twithin\tthe\tU.S.\tby\tthe\tDepartment\tof\tEnergy\tand\tthe\tNational\nInstitutes\tof\tHealth.\tThe\tinitial\tgoal\twas\tto\tidentify\teach\tof\tthe\t3\tbillion\tnucleotides\tin\thuman | [
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disease,\tparticularly\tfor\tthe\tchronic\tdiseases\twhose\tprevalence\twas\n\tsignificant\tworldwide.\tA\nnumber\tof\tdisciplines\temerged\tcorresponding\tto\tthe\tvarious\tsteps\tin\tthe\tprocesses,\tfrom\nretrieving\tinformation\tto\ttranslating\tthat\tinformation\tinto\tproteins\tto\tregulating\tgene\texpression. | [
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This\tlatter\tprocess\tincludes\tepigenetics,\twhich\thas\tbeen\ta\tbit\tof\ta\t“missing\tlink”\tin\tunderstanding\nhow\tgenes\tgive\trise\tto\tchronic\tdiseases,\twhich\tis\tessential\tfor\tdeveloping\teffective\n\tclinical\napplications\tand\tfor\tdisease\tprevention.\tSee\t\nBox\t6.2\n\tfor\tinformation\tabout\tthe\tprimary\t“omic” | [
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Box\t6.2\n\tfor\tinformation\tabout\tthe\tprimary\t“omic”\ndisciplines\tthat\thave\temerged.\tEach\tof\tthese\tdisciplines\thas\tcontinued\tdeveloping\tas\ta\tprimary\nresearch\tfocus\tand\tis\tcontributing\tvaluable\tinsight\tinto\tthe\tgene/environment/health\tand\tdisease\nconnections.\nAnother\tmajor\taccomplishment\tof\tthe\tinitial\tHGP\twork\thas\tbeen\tthe\tadvances\tthat\thave\noccurred | [
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with\twhich\tthe\twork\tcan\tbe\tconducted\tand\tdecreased\tthe\tcost\tof\tsequencing.\tAdditionally,\tthe\ngenomes\tof\tnumerous\tother\torganisms\n\thave\tbeen\tsequenced.\tSome\tof\tthese\torganisms,\tsuch\tas\nthe\tlaboratory\tmouse,\thave\tserved\ta\tvaluable\trole\tas\tmodel\tsystems\tfor\tunderstanding\thuman | [
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processes.\tThe\tgenetics\tand\tenvironmental\tconditions\tof\tmodel\tsystems\tcan\tbe\tmanipulated\tand\nthe\tmolecular,\tbiochemical,\tand\tphysiologic\toutcomes\tstudied\tas\twell\tas\tthe\theritability\tof\tany\nchanges\tnoted.\tThe\tHGP\talso\temphasized\teducating\tgenetic\tscientists\n\tand\tclinicians,\tintegrating | [
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and\tclinicians,\tintegrating\nthe\tresults\tof\tgenetic\tresearch\tinto\tclinical\tpractice,\tand\tdeveloping\tsophisticated\tcomputer\ntechnology\t(bioinformatics)\tin\torder\tto\tmake\tsense\tof\tthe\tlarge\tvolume\tof\tdata\tthat\twould\tbe\ngenerated.\tAs\ta\tresult\tof\tthis\tcollaborative\teffort\ton\ta\tglobal\tscale,\tthe\tera\tof\tprecision\thealth, | [
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only\tdreamed\tabout\tin\t1990,\tis\tnow\ta\tviable\tgoal\tfor\thealth\tcare.\tFor\ta\thistory\n\tof\tthe\tHuman\nGenome\tProject,\tsee\tthe\tNational\tHuman\tGenome\tResearch\tInstitute’s\twebsite.\nBOX\t6.2\nGenomics\tand\tOther\t“Omic”\tDisciplines\nSeveral\tnew\tdisciplines,\ttechnologies,\tand\ttools\tapplicable\tto\thealth\tcare\thave\tdeveloped\tfrom\tthe | [
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Human\tGenome\tProject.\tThe\tmajor\tdisciplines\thave\tbeen\tgenomics,\tproteomics,\tmetabolomics,\nand\tmicrobiomics.\t\nGenomics\n\tis\tthe\tstudy\tof\torganisms\tand\ttheir\n\tgenetic\tmaterial\t(the\tgenome):\ncomposition,\torganization,\tand\tfunction.\nThe\tgenome\t(total\tDNA\tsequence)\tis\ttranscribed\tinto\tcoding\tand\tnoncoding\tRNA\ttranscripts.\nTranscriptomics | [
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Transcriptomics\n\tis\tthe\tstudy\tof\tthe\ttranscripts\tproduced:\tthe\ttypes\tof\ttranscripts\tgenome-wide\nand\tthe\tamount\tproduced.\tThe\tcoding\tRNA\tcontains\tinformation\tneeded\tto\tsynthesize\tproteins\nand\twas\toriginally\tthought\tto\tbe\tthe\tonly\tfunctional\n\ttype\tof\tRNA.\tTranscriptomics\tresearch\thas | [
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type\tof\tRNA.\tTranscriptomics\tresearch\thas\nrevealed\tthat\tthe\tmajority\tof\tthe\tgenome\tis\ttranscribed\tbut\tthat\tnoncoding\tRNA\tcomprises\tmost\nof\tthe\ttranscripts\tproduced.\tAlthough\ttheir\tphysiologic\troles\tare\tonly\tbeginning\tto\tbe\tunderstood,\nsome\tof\tthese\ttranscripts\tare\tbeing\tfound\tto\tbe\tassociated\twith\tdisease.\nProteomics | [
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biofluids,\ttissues,\tand\torgans.\nMicrobiomics\n\tconcerns\tthe\tmicrobial\tecology\tof\tbody\tcavities,\tsuch\tas\tthe\tdigestive\ttract\tand\nthe\toral\tcavity,\tanother\timportant\tbody\tcavity\tin\tnutrition\tpractice.\tBeneficial\tand\tpathogenic\nmicrobes\tcolonize\tthese\tcavities\tand\tinfluence\n\thealth.\tThe\tHuman\tMicrobiome\tProject\n(\nhttps://hmpdacc.org | [
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health.\tThe\tHuman\tMicrobiome\tProject\n(\nhttps://hmpdacc.org\n)\thas\tbeen\tinstrumental\tin\tidentifying\twhich\tmicrobes\tare\tpresent\tin\thealth | [
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predict\ta\tpatient’s\tresponse\tto\ta\tdrug.\tGenetic\tvariability\ncan\tlead\tto\tdiffering\tfunction\tin\tthese\tenzymes,\twhich\texplains\twhy\ta\tdrug\tmay\thave\tthe\tintended\neffects\tfor\tone\tperson,\tbe\tineffective\tfor\tanother,\tand\tbe\tharmful\tto\ta\tthird.\tIn\taddition\tto | [
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identifying\tindividuals\tfor\twhom\tthe\tdrug\ttherapy\twill\tbe\tbeneficial,\tit’s\tpossible\tto\tcalculate\tthe\nappropriate\tstarting\tdosage\tand\tminimize\tadverse\n\tevents.\tThe\tcommon\tblood-thinning\tmedication\nwarfarin\tprovides\tan\texample\tof\tpharmacogenomics\tand\tits\tclinical\tapplications\t(see\t\nBox\t6.14\n). | [
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Box\t6.14\n).\nMany\tgenetic\ttechnologies\tand\ttools\thave\tbeen\tdeveloped\tfor\tthe\tvarious\t“omics”\tdisciplines.\nBasic\tDNA\tsequencing\ttechnology\tapplied\tto\tmicrobiomics\thas\tsignificantly\tshortened\tthe\ttime\nneeded\tto\tidentify\tpathogenic\tmicroorganisms,\twhich\tallows\tantimicrobial\n\ttherapy\tto\tbe\tinitiated | [
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growth\tin\tthe\tfield\tof\tbioinformatics.\tThe\tability\tof\tsophisticated\tcomputers\tto\torganize,\n\tstore,\nand\tretrieve\tmassive\tamounts\tof\tdata\thas\tbeen\tintegral\tto\tthe\trapid\tadvances\tof\tthe\tgenomics\nera.\nBOX\t6.14\nApplication\tof\tPharmacogenomics:\tWarfarin\nOne\tof\tthe\tearliest\tclinical\tapplications\tof\tthe\t“omic”\tdisciplines\thas\tbeen\tin\tpharmacogenomics, | [
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it\tbecomes\tpossible\tto\tidentify\nindividuals\tfor\twhom\tthe\tdrug\ttherapy\twill\tbe\tbeneficial\tbut\talso\tto\tassist\twith\tcalculating\tthe\nappropriate\tdose\tfrom\tthe\toutset\tof\ttherapy.\tFor\tdrugs\twith\tnarrow\ttherapeutic\twindows\tof\nefficacy,\tprescribing\tthe\tcorrect\tdosage\tfrom\tthe\toutset\tof\ttherapy\timproves\tefficacy\tand\treduces | [
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the\tpotential\tfor\tadverse\tevents.\tSeveral\tdrugs\thave\tnow\tbeen\tassociated\twith\n\tgene\tvariants\tand\ngenetic\ttesting\tis\tavailable\tbefore\tbeginning\ttherapy.\nThe\tblood-thinning\tmedication\twarfarin\thas\ta\tnarrow\ttherapeutic\twindow\tand\tis\twidely\tused.\nAssociated\twith\tfrequent\tadverse\tevents,\twarfarin\twas\tone\tof\tthe\tearliest\tdrugs\tto\twhich | [
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pharmacogenomics\twas\tapplied.\tVariation\tin\tthe\t\nCYP2C9,\tVKORC1,\n\tor\t\nCYP4F2\n\tgenes\tinfluence\nits\tsafe\tuse.\tThe\tmost\trecent\tcomprehensive\ttrial\tto\n\ttest\tthe\tclinical\tutility\tof\twarfarin\npharmacogenetics\tis\tthe\tClarification\tof\tOptimal\tAnticoagulation\tThrough\tGenetics\t(COAG)\ttrial\n(\nGage\tet\tal,\t2017 | [
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(\nGage\tet\tal,\t2017\n).\tThe\tdata\tdemonstrated\tthat\tgenotype-guided\tdosing\tof\twarfarin\twas\tsuperior\nto\tstandard\tmanagement\tin\ttwo\tways:\t(1)\tefficacy,\tin\tincreasing\tthe\tamount\tof\tdrug\tin\tthe\ntherapeutic\trange\tover\tthe\tperiod\tof\tthe\ttrial\tand\t(2)\tsafety,\tfor\treducing\tadverse\n\tevents\tup\tto\t30\ndays\tfollowing\tthe\tend\tof\tthe\ttrial. | [
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events\tup\tto\t30\ndays\tfollowing\tthe\tend\tof\tthe\ttrial.\nAn\tinteresting\taspect\tof\tthis\ttrial\tpoints\tout\ta\tmajor\tlimitation\tof\tgenomics\tto\tdate:\tthe\tdatabase\nof\tgene\tvariants\thas\tbeen\tdeveloped\tprimarily\tfrom\tindividuals\tof\tEuropean\tdescent.\tGene\tpools\nvary\tamong\tdifferent\tancestral\tpopulations\tand,\tto\tbe\teffective,\trecommendations\tmust\tbe\tbased | [
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on\tthe\tgene\tvariants\tappropriate\tto\teach\tpopulation.\n\tThe\tCOAG\ttrial\tdid\tnot\ttest\tfor\tthe\nCYP2C9*8\n\tvariant\tthat\tis\tan\timportant\tpredictor\tof\twarfarin\tdose\tin\tAfrican\tAmericans\t(\nNagai\tet\nal,\t2015\n).\tThese\tindividuals\tspent\tless\ttime\twithin\tthe\ttherapeutic\twindow\tand\tdid\tnot\treceive\tthe | [
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full\teffect\tof\tthe\tdrug.\tBecause\tthe\tstudy\tpopulation\twas\t91%\twhite,\tthe\toverall\teffectiveness\tof\nthe\tdrug\tfor\tthe\tgenotyped\tarm\twas\tnot\taffected.\tHowever,\tgenotyping\n\tfor\twarfarin\twill\tlikely\tnot\nbe\trecommended\tfor\tAfrican\tAmericans\tuntil\tfurther\tresearch\tclarifies\tthe\tset\tof\tgene\tvariants | [
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] |
that\tbest\tprovides\tsafety\tand\tefficacy\tfor\tthis\tpopulation.\tThis\tlimitation\tin\tthe\tgene\tvariant\ndatabase\tis\twell\trecognized\tby\tresearchers\tand\ta\tglobal\teffort\tis\tunderway\tto\texpand\tthe\ndatabase.\tSee\t\nBox\t6.12\n\tfor\tadditional\tinformation.\tThis\tproject\tis\texpanding\tthe\tpopulations | [
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included\tand\thelping\tidentify\tcommon\tmutations\tassociated\twith\tspecific\tethnic\tgroups.\nAdditionally,\tvarious\tcountries\tare\testablishing\tdatabases\tthat\trepresent\ttheir\tspecific\npopulations.\nBOX\t6.12\nThe\t1000\tGenomes\tProject\nLike\tthe\tHuman\tGenome\tProject,\tthe\t1000\tGenomes\tProject\tis\ta\tsignificant\tstep\tforward\tin\tthe | [
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Native\tAmerican),\tEast\tAsian,\tEuropean,\tand\tSouth\tAsian.\nThe\tgoal\tof\tthe\tproject\twas\tto\tidentify\tgenetic\tvariations\tthat\toccurred\tin\t1%\tor\tgreater\tof\tthe\npopulations\tstudied.\tOver\t84.7\tmillion\tsingle\tnucleotide\tpolymorphisms\t(SNPs),\t3.6\tmillion\tshort | [
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projected\tto\tbe\tin\tthe\thuman\tgenome\tat\t1%\tor\tgreater\tin\tfrequency\thave\tbeen\tidentified.\tThis\nproject\tis\ta\tmajor\tstep\tforward\tfor\tpersonalized\thealth\tcare.\tFuture\tresearch\twill\tlikely\tfocus\ton\ndetecting\tstrong\tassociations\tbetween\tspecific\tgenetic\tregions\tand\tparticular\tdiseases\tand\tthen | [
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focusing\ton\tgenetic\tvariation\tis\trevolutionizing\tthe\tway\tclinicians\tthink\tabout\tthe\tclinical\taspects\nof\tmedicine,\tpharmacology,\tand\tnutrition.\tGiven\tthe\tmagnitude\tof\tvariation\tamong\tindividuals,\nclinical\tapproaches\twill\tincreasingly\taccommodate\tthe\tshift\tfrom\tone-size-fits-all\tto\tpersonalized\napproaches\t(\n1000\tGenomes\tProject\tConsortium,\t2015\n). | [
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approaches\t(\n1000\tGenomes\tProject\tConsortium,\t2015\n).\nThe\tbasic\tunit\tof\theredity\tis\tthe\t\ngene\n,\twhich\tis\tmade\tup\tof\t\nDNA\t(deoxyribonucleic\tacid)\n.\tThe\nnucleotide\tsequence\tof\ta\tgene\tencodes\tthe\tinstructions\tfor\tmaking\ta\tprotein\tor\ta\tpeptide\tcomponent\nof\ta\tprotein.\tChanges\tin\tthe\tnucleotide\tsequence\n\tof\tthe\tDNA\tare\ttranslated\tinto\tthe\tamino\tacid | [
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] |
of\tthe\tDNA\tare\ttranslated\tinto\tthe\tamino\tacid\nsequence\tof\tthe\tprotein\tand\tcan\tpotentially\tchange\tthe\tability\tof\tthat\tprotein\tto\tperform\tits\trole.\nThese\tchanges\tare\tpassed\tfrom\tparent\tto\tchild\tand\tare\tthe\tbasis\tfor\tinheritance\tof\ttraits.\tIn\thigher\norganisms\tthe\tDNA\tis\thoused\twithin\tthe\tnucleus\tof\tcells\t(\nFig.\t6.1\n).\tThe\tDNA\tmolecule\tis\ta\tdouble | [
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] |
Fig.\t6.1\n).\tThe\tDNA\tmolecule\tis\ta\tdouble\nhelix\tconsisting\tof\ttwo\tstrands\tof\t\nnucleotide\n\tsubunits\n\theld\ttogether\tby\thydrogen\tbonds.\tEach\nnucleotide\tcontains\tthe\tsugar\tdeoxyribose,\tthe\tmineral\tphosphorus,\tand\tone\tof\tfour\tnitrogen-\ncontaining\tbases:\tadenine\t(A),\tthymine\t(T),\tguanine\t(G),\tor\tcytosine\t(C).\tAny\tbase\tcan\tsit\tnext\tto\tone | [
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another,\tbut\tacross\tstrands\tof\tthe\thelix,\tthese\tbases\tpair\tspecifically:\tA\tpairs\twith\tT,\tG\tpairs\twith\tC\n(\nFig.\t6.2\n).\tThe\tnucleotides\tare\tarranged\tin\ta\tlinear\torder,\n\tand\tthis\torder\tdetermines\tthe\tparticular\ninformation\tencoded\tin\ta\tstretch\tof\tDNA\tthat\tresults\tin\tthe\tsynthesis\tof\ta\tprotein.\tThe\tnucleotide | [
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acid.\n\tSource:\t\n(From\tU.S.\tDepartment\tof\tEnergy,\tHuman\tGenome\tProgram:\t\nwww.ornl.gov/hgmis\n.) | [
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FIG.\t6.2\nDNA\t\nReplication\tPrior\tto\tCell\tDivision.\n\t\nEach\ttime\ta\tcell\tdivides\tinto\ttwo\tdaughter\tcells,\tits\tfull\ngenome\tis\tduplicated;\tfor\thumans\tand\tother\tcomplex\torganisms,\tthis\tduplication\toccurs\tin\tthe\tnucleus.\tDuring\ncell\tdivision\tthe\tdeoxyribonucleic\tacid\t(DNA)\tmolecule\tunwinds,\tand\tthe\tweak\tbonds\tbetween\tthe\tbase\tpairs | [
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break,\tallowing\tthe\tstrands\tto\tseparate.\tEach\tstrand\tdirects\tthe\tsynthesis\n\tof\ta\tcomplementary\tnew\tstrand,\nwith\tfree\tnucleotides\tmatching\tup\twith\ttheir\tcomplementary\tbases\ton\teach\tof\tthe\tseparated\tstrands.\tStrict\nbase-pairing\trules\tare\tadhered\tto\t(i.e.,\tadenine\tpairs\tonly\twith\tthymine\t[an\tA-T\tpair]\tand\tcytosine\twith\tguanine | [
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[a\tC-G\tpair]).\tEach\tdaughter\tcell\treceives\tone\told\tand\tone\tnew\tDNA\tstrand.\tThe\tcells’\tadherence\tto\tthese\nbase-pairing\trules\tensures\tthat\tthe\tnew\n\tstrand\tis\tan\texact\tcopy\tof\tthe\told\tone.\tThis\tminimizes\tthe\tincidence\tof\nerrors\t(mutations)\tthat\tmay\tgreatly\taffect\tthe\tresulting\torganism\tor\tits\toffspring.\n\tSource:\t\n(From\tU.S.\tDepartment\tof | [
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Source:\t\n(From\tU.S.\tDepartment\tof\nEnergy,\tHuman\tGenome\tProgram:\t\nwww.ornl.gov/hgmis\n.)\nTo\tbe\tuseful\tto\tthe\tcells,\tinformation\tin\tthe\tDNA\tfirst\tmust\tbe\tdecoded\tand\ttranslated\tinto\nproteins,\twhich\tperform\tthe\twork\tof\tthe\torganism’s\t“operating\n\tsystem.”\tA\tsequence\tof\tDNA | [
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system.”\tA\tsequence\tof\tDNA\nnucleotides\tthat\tencodes\tthe\tinformation\tfor\tsynthesizing\ta\tprotein\tis\tcalled\ta\tgene.\tHuman\tDNA\ncontains\tapproximately\t20,000\tgenes.\tEach\tgene\thas\ta\tlocation\tor\t“address”\tat\ta\tspecific\tsite\ton\ta\nparticular\tchromosome.\tLong\tstretches\tof\tnucleotides\toften\tare\tfound\tbetween\tgenes\talong\tthe | [
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