Moussab/ORKG-training-evaluation-set huggingface dataset:
Research field: Materials Chemistry
Title: Side-Chain Isomerization on an n-type Organic Semiconductor ITIC Acceptor Makes 11.77% High Efficiency Polymer Solar Cells
Abstract: Low bandgap n-type organic semiconductor (n-OS) ITIC has attracted great attention for the application as an acceptor with medium bandgap p-type conjugated polymer as donor in nonfullerene polymer solar cells (PSCs) because of its attractive photovoltaic performance. Here we report a modification on the molecular structure of ITIC by side-chain isomerization with meta-alkyl-phenyl substitution, m-ITIC, to further improve its photovoltaic performance. In a comparison with its isomeric counterpart ITIC with para-alkyl-phenyl substitution, m-ITIC shows a higher film absorption coefficient, a larger crystalline coherence, and higher electron mobility. These inherent advantages of m-ITIC resulted in a higher power conversion efficiency (PCE) of 11.77% for the nonfullerene PSCs with m-ITIC as acceptor and a medium bandgap polymer J61 as donor, which is significantly improved over that (10.57%) of the corresponding devices with ITIC as acceptor. To the best of our knowledge, the PCE of 11.77% is one of the highest values reported in the literature to date for nonfullerene PSCs. More importantly, the m-ITIC-based device shows less thickness-dependent photovoltaic behavior than ITIC-based devices in the active-layer thickness range of 80-360 nm, which is beneficial for large area device fabrication. These results indicate that m-ITIC is a promising low bandgap n-OS for the application as an acceptor in PSCs, and the side-chain isomerization could be an easy and convenient way to further improve the photovoltaic performance of the donor and acceptor materials for high efficiency PSCs.
Extracted statement — Acceptor: m-ITIC
Research field: Materials Chemistry
Title: Mapping Intracellular Temperature Using Green Fluorescent Protein
Abstract: Heat is of fundamental importance in many cellular processes such as cell metabolism, cell division and gene expression. (1-3) Accurate and noninvasive monitoring of temperature changes in individual cells could thus help clarify intricate cellular processes and develop new applications in biology and medicine. Here we report the use of green fluorescent proteins (GFP) as thermal nanoprobes suited for intracellular temperature mapping. Temperature probing is achieved by monitoring the fluorescence polarization anisotropy of GFP. The method is tested on GFP-transfected HeLa and U-87 MG cancer cell lines where we monitored the heat delivery by photothermal heating of gold nanorods surrounding the cells. A spatial resolution of 300 nm and a temperature accuracy of about 0.4 °C are achieved. Benefiting from its full compatibility with widely used GFP-transfected cells, this approach provides a noninvasive tool for fundamental and applied research in areas ranging from molecular biology to therapeutic and diagnostic studies.
Extracted statement — Material: Protein
Research field: Materials Chemistry
Title: N,S co-doped carbon dots as a stable bio-imaging probe for detection of intracellular temperature and tetracycline
Abstract: Stable bioimaging with nanomaterials in living cells has been a great challenge and of great importance for understanding intracellular events and elucidating various biological phenomena. Herein, we demonstrate that N,S co-doped carbon dots (N,S-CDs) produced by one-pot reflux treatment of C3N3S3 with ethane diamine at a relatively low temperature (80 °C) exhibit a high fluorescence quantum yield of about 30.4%, favorable biocompatibility, low-toxicity, strong resistance to photobleaching and good stability. The N,S-CDs as an effective temperature indicator exhibit good temperature-dependent fluorescence with a sensational linear response from 20 to 80 °C. In addition, the obtained N,S-CDs facilitate high selectivity detection of tetracycline (TC) with a detection limit as low as 3 × 10-10 M and a wide linear range from 1.39 × 10-5 to 1.39 × 10-9 M. More importantly, the N,S-CDs display an unambiguous bioimaging ability in the detection of intracellular temperature and TC with satisfactory results.
Extracted statement — Method of nanomaterial synthesis: Reflux
Research field: Mechanical Process Engineering
Title: Investigations on Tailored Forming of AISI 52100 as Rolling Bearing Raceway
Abstract: Hybrid cylindrical roller thrust bearing washers of type 81212 were manufactured by tailored forming. An AISI 1022M base material, featuring a sufficient strength for structural loads, was cladded with the bearing steel AISI 52100 by plasma transferred arc welding (PTA). Though AISI 52100 is generally regarded as non-weldable, it could be applied as a cladding material by adjusting PTA parameters. The cladded parts were investigated after each individual process step and subsequently tested under rolling contact load. Welding defects that could not be completely eliminated by the subsequent hot forming were characterized by means of scanning acoustic microscopy and micrographs. Below the surface, pores with a typical size of ten µm were found to a depth of about 0.45 mm. In the material transition zone and between individual weld seams, larger voids were observed. Grinding of the surface after heat treatment caused compressive residual stresses near the surface with a relatively small depth. Fatigue tests were carried out on an FE8 test rig. Eighty-two percent of the calculated rating life for conventional bearings was achieved. A high failure slope of the Weibull regression was determined. A relationship between the weld defects and the fatigue behavior is likely.
Extracted statement — has material: material
Research field: Mechanical Process Engineering
Title: Manufacturing and Evaluation of Multi-Material Axial-Bearing Washers by Tailored Forming
Abstract: <jats:p>Components subject to rolling contact fatigue, such as gears and rolling bearings, are among the fundamental machine elements in mechanical and vehicle engineering. Rolling bearings are generally not designed to be fatigue-resistant, as the necessary oversizing is not technically and economically marketable. In order to improve the load-bearing capacity, resource efficiency and application possibilities of rolling bearings and other possible multi-material solid components, a new process chain was developed at Leibniz University Hannover as a part of the Collaborative Research Centre 1153 “Tailored Forming”. Semi-finished products, already joined before the forming process, are used here to allow a further optimisation of joint quality by forming and finishing. In this paper, a plasma-powder-deposition welding process is presented, which enables precise material deposition and control of the welding depth. For this study, bearing washers (serving as rolling bearing raceways) of a cylindrical roller thrust bearing, similar to type 81212 with a multi-layer structure, were manufactured. A previously non-weldable high-performance material, steel AISI 5140, was used as the cladding layer. Depending on the degree of forming, grain-refinement within the welded material was achieved by thermo-mechanical treatment of the joining zone during the forming process. This grain-refinements lead to an improvement of the mechanical properties and thus, to a higher lifetime for washers of an axial cylindrical roller bearing, which were examined as an exemplary component on a fatigue test bench. To evaluate the bearing washers, the results of the bearing tests were compared with industrial bearings and deposition welded axial-bearing washers without subsequent forming. In addition, the bearing washers were analysed micro-tribologically and by scanning acoustic microscopy both after welding and after the forming process. Nano-scratch tests were carried out on the bearing washers to analyse the layer properties. Together with the results of additional microscopic images of the surface and cross-sections, the causes of failure due to fatigue and wear were identified.</jats:p>
Extracted statement — has material: material
Research field: Mechanical Process Engineering
Title: Tribological Study on Tailored-Formed Axial Bearing Washers
Abstract: To enhance tribological contacts under cyclic load, high performance materials are required. Utilizing the same high-strength material for the whole machine element is not resource-efficient. In order to manufacture machine elements with extended functionality and specific properties, a combination of different materials can be used in a single component for a more efficient material utilization. By combining different joining techniques with subsequent forming, multi-material or tailored components can be manufactured. To reduce material costs and energy consumption during the component service life, a less expensive lightweight material should be used for regions remote from the highly stressed zones. The scope is not only to obtain the desired shape and dimensions for the finishing process, but also to improve properties like the bond strength between different materials and the microscopic structure of the material. The multi-material approach can be applied to all components requiring different properties in separate component regions such as shafts, bearings or bushes. The current study exemplarily presents the process route for the production of an axial bearing washer by means of tailored forming technology. The bearing washers were chosen to fit axial roller bearings (type 81212). The manufacturing process starts with the laser wire cladding of a hard facing made of martensitic chromium silicon steel (1.4718) on a base substrate of S235 (1.0038) steel. Subsequently, the bearing washers are forged. After finishing, the surfaces of the bearing washers were tested in thrust bearings on an FE-8 test rig. The operational test of the bearings consists in a run-in phase at 250 rpm. A bearing failure is determined by a condition monitoring system. Before and after this, the bearings were inspected by optical and ultrasonic microscopy in order to examine whether the bond of the coat is resistant against rolling contact fatigue. The feasibility of the approach could be proven by endurance test. The joining zone was able to withstand the rolling contact stresses and the bearing failed due to material-induced fatigue with high cycle stability.
Extracted statement — has material: material
Research field: Mechanical Process Engineering
Title: Cross-wedge rolling of PTA-welded hybrid steel billets with rolling bearing steel and hard material coatings
Abstract: Within the Collaborative Research Centre 1153 “Tailored Forming“ a process chain for the manufacturing of hybrid high performance components is developed. Exemplary process steps consist of deposit welding of high performance steel on low-cost steel, pre-shaping by cross-wedge rolling and finishing by milling.Hard material coatings such as Stellite 6 or Delcrome 253 are used as wear or corrosion protection coatings in industrial applications. Scientists of the Institute of Material Science welded these hard material alloys onto a base material, in this case C22.8, to create a hybrid workpiece. Scientists of the Institut fur Integrierte Produktion Hannover have shown that these hybrid workpieces can be formed without defects (e.g. detachment of the coating) by cross-wedge rolling. After forming, the properties of the coatings are retained or in some cases even improved (e.g. the transition zone between base material and coating). By adjustments in the welding process, it was possible to apply the 100Cr6 rolling bearing steel, as of now declared as non-weldable, on the low-cost steel C22.8. 100Cr6 was formed afterwards in its hybrid bonding state with C22.8 by cross-wedge rolling, thus a component-integrated bearing seat was produced. Even after welding and forming, the rolling bearing steel coating could still be quench-hardened to a hardness of over 60 HRC. This paper shows the potential of forming hybrid billets to tailored parts. Since industrially available standard materials can be used for hard material coatings by this approach, even though they are not weldable by conventional methods, it is not necessary to use expensive, for welding designed materials to implement a hybrid component concept.Within the Collaborative Research Centre 1153 “Tailored Forming“ a process chain for the manufacturing of hybrid high performance components is developed. Exemplary process steps consist of deposit welding of high performance steel on low-cost steel, pre-shaping by cross-wedge rolling and finishing by milling.Hard material coatings such as Stellite 6 or Delcrome 253 are used as wear or corrosion protection coatings in industrial applications. Scientists of the Institute of Material Science welded these hard material alloys onto a base material, in this case C22.8, to create a hybrid workpiece. Scientists of the Institut fur Integrierte Produktion Hannover have shown that these hybrid workpieces can be formed without defects (e.g. detachment of the coating) by cross-wedge rolling. After forming, the properties of the coatings are retained or in some cases even improved (e.g. the transition zone between base material and coating). By adjustments in the welding process, it was possible to apply the 100Cr6 ro...
Extracted statement — has material: material
Research field: Mechanical Process Engineering
Title: Investigation of the material combination 20MnCr5 and X45CrSi9-3 in the Tailored Forming of shafts with bearing seats
Abstract: Abstract The Tailored Forming process chain is used to manufacture hybrid components and consists of a joining process or Additive Manufacturing for various materials (e.g. deposition welding), subsequent hot forming, machining and heat treatment. In this way, components can be produced with materials adapted to the load case. For this paper, hybrid shafts are produced by deposition welding of a cladding made of X45CrSi9-3 onto a workpiece made from 20MnCr5. The hybrid shafts are then formed by means of cross-wedge rolling. It is investigated, how the thickness of the cladding and the type of cooling after hot forming (in air or in water) affect the properties of the cladding. The hybrid shafts are formed without layer separation. However, slight core loosening occurres in the area of the bearing seat due to the Mannesmann effect. The microhardness of the cladding is only slightly effected by the cooling strategy, while the microhardness of the base material is significantly higher in water cooled shafts. The microstructure of the cladding after both cooling strategies consists mainly of martensite. In the base material, air cooling results in a mainly ferritic microstructure with grains of ferrite-pearlite. Quenching in water results in a microstructure containing mainly martensite.
Extracted statement — has material: material
Research field: Medical Informatics and Medical Bioinformatics
Title: 2010 i2b2/VA challenge on concepts, assertions, and relations in clinical text
Abstract: The 2010 i2b2/VA Workshop on Natural Language Processing Challenges for Clinical Records presented three tasks: a concept extraction task focused on the extraction of medical concepts from patient reports; an assertion classification task focused on assigning assertion types for medical problem concepts; and a relation classification task focused on assigning relation types that hold between medical problems, tests, and treatments. i2b2 and the VA provided an annotated reference standard corpus for the three tasks. Using this reference standard, 22 systems were developed for concept extraction, 21 for assertion classification, and 16 for relation classification. These systems showed that machine learning approaches could be augmented with rule-based systems to determine concepts, assertions, and relations. Depending on the task, the rule-based systems can either provide input for machine learning or post-process the output of machine learning. Ensembles of classifiers, information from unlabeled data, and external knowledge sources can help when the training data are inadequate.
Extracted statement — Concept types: Problem
Research field: Medical Informatics and Medical Bioinformatics
Title: 2010 i2b2/VA challenge on concepts, assertions, and relations in clinical text
Abstract: The 2010 i2b2/VA Workshop on Natural Language Processing Challenges for Clinical Records presented three tasks: a concept extraction task focused on the extraction of medical concepts from patient reports; an assertion classification task focused on assigning assertion types for medical problem concepts; and a relation classification task focused on assigning relation types that hold between medical problems, tests, and treatments. i2b2 and the VA provided an annotated reference standard corpus for the three tasks. Using this reference standard, 22 systems were developed for concept extraction, 21 for assertion classification, and 16 for relation classification. These systems showed that machine learning approaches could be augmented with rule-based systems to determine concepts, assertions, and relations. Depending on the task, the rule-based systems can either provide input for machine learning or post-process the output of machine learning. Ensembles of classifiers, information from unlabeled data, and external knowledge sources can help when the training data are inadequate.
Extracted statement — Concept types: Test
Research field: Medical Informatics and Medical Bioinformatics
Title: 2010 i2b2/VA challenge on concepts, assertions, and relations in clinical text
Abstract: The 2010 i2b2/VA Workshop on Natural Language Processing Challenges for Clinical Records presented three tasks: a concept extraction task focused on the extraction of medical concepts from patient reports; an assertion classification task focused on assigning assertion types for medical problem concepts; and a relation classification task focused on assigning relation types that hold between medical problems, tests, and treatments. i2b2 and the VA provided an annotated reference standard corpus for the three tasks. Using this reference standard, 22 systems were developed for concept extraction, 21 for assertion classification, and 16 for relation classification. These systems showed that machine learning approaches could be augmented with rule-based systems to determine concepts, assertions, and relations. Depending on the task, the rule-based systems can either provide input for machine learning or post-process the output of machine learning. Ensembles of classifiers, information from unlabeled data, and external knowledge sources can help when the training data are inadequate.
Extracted statement — Concept types: Treatment
Research field: Medicinal Chemistry and Pharmaceutics
Title: Cyclodextrins in acetazolamide eye drop formulations
Abstract: The interaction of acetazolamide with beta-cyclodextrin, (beta-CD), dimethyl-beta-cyclodextrin (DM-beta-CD) and trimethyl-beta-cyclodextrin (TM-beta-CD) was monitored spectrophotometrically. The results revealed formation of equimolar complexes. The apparent solubility of acetazolamide in water was found to increase linearly with increasing CD concentration. The effect of CDs on the permeation of acetazolamide through semi-permeable membranes and the topical delivery of acetazolamide was investigated. Maximum acetazolamide penetration was obtained when just enough CD was used to keep all acetazolamide in solution. For an acetazolamide concentration of 10 mg/ml, the optimum CD concentration appeared to be 3.5 mmol/l for beta-CD, 2.8 mmol/l for TM-beta-CD and 6.0 mmol/l for DM-beta-CD. The effect of CDs on the bioavailability of acetazolamide was assessed by measuring the intraocular pressure in rabbits. The results indicated that CDs have a significant influence on the biological performance of the drug leading to augmentation in its intensity of action and bioavailability as well as prolongation in its duration of action.
Extracted statement — Uses drug: Acetazolamide
Research field: Medicinal Chemistry and Pharmaceutics
Title: Topically effective ocular hypotensive acetazolamide and ethoxyzolamide formulations in rabbits
Abstract: Abstract— The effect of topically active 2‐hydroxypropyl‐β‐cyclodextrin (HP‐β‐CyD) eye‐drop formulations containing solutions of acetazolamide, ethoxyzolamide or timolol on the intra‐ocular pressure (IOP) was investigated in normotensive conscious rabbits. Both acetazolamide and ethoxyzolamide were active but their IOP‐lowering effect was less than that of timolol. The IOP‐lowering effects of acetazolamide and ethoxyzolamide and that of timolol appeared to be to some extent additive. Combination of acetazolamide and timolol or ethoxyzolamide and timolol in one HP‐β‐CyD formulation resulted in a significant increase in the duration of activity compared with HP‐β‐CyD formulations containing only acetazolamide, ethoxyzolamide or timolol. Also, it was possible to increase the IOP‐lowering effect of acetazolamide by formulating the drug as a suspension in an aqueous HP‐β‐CyD vehicle.
Extracted statement — Uses drug: Acetazolamide
Research field: Medicinal Chemistry and Pharmaceutics
Title: Multiplex Paper-Based Colorimetric DNA Sensor Using Pyrrolidinyl Peptide Nucleic Acid-Induced AgNPs Aggregation for Detecting MERS-CoV, MTB, and HPV Oligonucleotides
Abstract: The development of simple fluorescent and colorimetric assays that enable point-of-care DNA and RNA detection has been a topic of significant research because of the utility of such assays in resource limited settings. The most common motifs utilize hybridization to a complementary detection strand coupled with a sensitive reporter molecule. Here, a paper-based colorimetric assay for DNA detection based on pyrrolidinyl peptide nucleic acid (acpcPNA)-induced nanoparticle aggregation is reported as an alternative to traditional colorimetric approaches. PNA probes are an attractive alternative to DNA and RNA probes because they are chemically and biologically stable, easily synthesized, and hybridize efficiently with the complementary DNA strands. The acpcPNA probe contains a single positive charge from the lysine at C-terminus and causes aggregation of citrate anion-stabilized silver nanoparticles (AgNPs) in the absence of complementary DNA. In the presence of target DNA, formation of the anionic DNA-acpcPNA duplex results in dispersion of the AgNPs as a result of electrostatic repulsion, giving rise to a detectable color change. Factors affecting the sensitivity and selectivity of this assay were investigated, including ionic strength, AgNP concentration, PNA concentration, and DNA strand mismatches. The method was used for screening of synthetic Middle East respiratory syndrome coronavirus (MERS-CoV), Mycobacterium tuberculosis (MTB), and human papillomavirus (HPV) DNA based on a colorimetric paper-based analytical device developed using the aforementioned principle. The oligonucleotide targets were detected by measuring the color change of AgNPs, giving detection limits of 1.53 (MERS-CoV), 1.27 (MTB), and 1.03 nM (HPV). The acpcPNA probe exhibited high selectivity for the complementary oligonucleotides over single-base-mismatch, two-base-mismatch, and noncomplementary DNA targets. The proposed paper-based colorimetric DNA sensor has potential to be an alternative approach for simple, rapid, sensitive, and selective DNA detection.
Extracted statement — Type of nanoparticles: AgNPs