Moussab/ORKG-training-evaluation-set huggingface dataset:
Research field: Molecular and Cellular Neuroscience
Title: Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer’s disease related pathology
Abstract: Abstract Aldehyde dehydrogenase 2 deficiency (ALDH2*2) causes facial flushing in response to alcohol consumption in approximately 560 million East Asians. Recent meta-analysis demonstrated the potential link between ALDH2*2 mutation and Alzheimer’s Disease (AD). Other studies have linked chronic alcohol consumption as a risk factor for AD. In the present study, we show that fibroblasts of an AD patient that also has an ALDH2*2 mutation or overexpression of ALDH2*2 in fibroblasts derived from AD patients harboring ApoE ε4 allele exhibited increased aldehydic load, oxidative stress, and increased mitochondrial dysfunction relative to healthy subjects and exposure to ethanol exacerbated these dysfunctions. In an in vivo model, daily exposure of WT mice to ethanol for 11 weeks resulted in mitochondrial dysfunction, oxidative stress and increased aldehyde levels in their brains and these pathologies were greater in ALDH2*2/*2 (homozygous) mice. Following chronic ethanol exposure, the levels of the AD-associated protein, amyloid-β, and neuroinflammation were higher in the brains of the ALDH2*2/*2 mice relative to WT. Cultured primary cortical neurons of ALDH2*2/*2 mice showed increased sensitivity to ethanol and there was a greater activation of their primary astrocytes relative to the responses of neurons or astrocytes from the WT mice. Importantly, an activator of ALDH2 and ALDH2*2, Alda-1, blunted the ethanol-induced increases in Aβ, and the neuroinflammation in vitro and in vivo. These data indicate that impairment in the metabolism of aldehydes, and specifically ethanol-derived acetaldehyde, is a contributor to AD associated pathology and highlights the likely risk of alcohol consumption in the general population and especially in East Asians that carry ALDH2*2 mutation.
Extracted statement — keywords: Neuroinflammation
Research field: Multiagent Systems
Title: A Multi-Agent System for the management of E-Government Services
Abstract: This paper aims at studying the exploitation of intelligent agents for supporting citizens to access e-government services. To this purpose, it proposes a multi-agent system capable of suggesting to the users the most interesting services for them; specifically, these suggestions are computed by taking into account both their exigencies/preferences and the capabilities of the devices they are currently exploiting. The paper first describes the proposed system and, then, reports various experimental results. Finally, it presents a comparison between our system and other related ones already presented in the literature.
Extracted statement — has Target users: Citizens
Research field: Nanoscience and Nanotechnology
Title: Bioinspired Cocatalysts Decorated WO3 Nanotube Toward Unparalleled Hydrogen Sulfide Chemiresistor
Abstract: Herein, we incorporated dual biotemplates, i.e., cellulose nanocrystals (CNC) and apoferritin, into electrospinning solution to achieve three distinct benefits, i.e., (i) facile synthesis of a WO3 nanotube by utilizing the self-agglomerating nature of CNC in the core of as-spun nanofibers, (ii) effective sensitization by partial phase transition from WO3 to Na2W4O13 induced by interaction between sodium-doped CNC and WO3 during calcination, and (iii) uniform functionalization with monodispersive apoferritin-derived Pt catalytic nanoparticles (2.22 ± 0.42 nm). Interestingly, the sensitization effect of Na2W4O13 on WO3 resulted in highly selective H2S sensing characteristics against seven different interfering molecules. Furthermore, synergistic effects with a bioinspired Pt catalyst induced a remarkably enhanced H2S response ( Rair/ Rgas = 203.5), unparalleled selectivity ( Rair/ Rgas < 1.3 for the interfering molecules), and rapid response (<10 s)/recovery (<30 s) time at 1 ppm of H2S under 95% relative humidity level. This work paves the way for a new class of cosensitization routes to overcome critical shortcomings of SMO-based chemical sensors, thus providing a potential platform for diagnosis of halitosis.
Extracted statement — keywords:  apoferritin
Research field: Nanoscience and Nanotechnology
Title: Bioinspired Cocatalysts Decorated WO3 Nanotube Toward Unparalleled Hydrogen Sulfide Chemiresistor
Abstract: Herein, we incorporated dual biotemplates, i.e., cellulose nanocrystals (CNC) and apoferritin, into electrospinning solution to achieve three distinct benefits, i.e., (i) facile synthesis of a WO3 nanotube by utilizing the self-agglomerating nature of CNC in the core of as-spun nanofibers, (ii) effective sensitization by partial phase transition from WO3 to Na2W4O13 induced by interaction between sodium-doped CNC and WO3 during calcination, and (iii) uniform functionalization with monodispersive apoferritin-derived Pt catalytic nanoparticles (2.22 ± 0.42 nm). Interestingly, the sensitization effect of Na2W4O13 on WO3 resulted in highly selective H2S sensing characteristics against seven different interfering molecules. Furthermore, synergistic effects with a bioinspired Pt catalyst induced a remarkably enhanced H2S response ( Rair/ Rgas = 203.5), unparalleled selectivity ( Rair/ Rgas < 1.3 for the interfering molecules), and rapid response (<10 s)/recovery (<30 s) time at 1 ppm of H2S under 95% relative humidity level. This work paves the way for a new class of cosensitization routes to overcome critical shortcomings of SMO-based chemical sensors, thus providing a potential platform for diagnosis of halitosis.
Extracted statement — keywords: biotemplates
Research field: Nanoscience and Nanotechnology
Title: Fabrication of a SnO2 Nanowire Gas Sensor and Sensor Performance for Hydrogen
Abstract: SnO2 nanowire gas sensors have been fabricated on Cd−Au comb-shaped interdigitating electrodes using thermal evaporation of the mixed powders of SnO2 and active carbon. The self-assembly grown sensors have excellent performance in sensor response to hydrogen concentration in the range of 10 to 1000 ppm. This high response is attributed to the large portion of undercoordinated atoms on the surface of the SnO2 nanowires. The influence of the Debye length of the nanowires and the gap between electrodes in the gas sensor response is examined and discussed.
Extracted statement — keywords: Electrodes
Research field: Nanoscience and Nanotechnology
Title: Bioinspired Cocatalysts Decorated WO3 Nanotube Toward Unparalleled Hydrogen Sulfide Chemiresistor
Abstract: Herein, we incorporated dual biotemplates, i.e., cellulose nanocrystals (CNC) and apoferritin, into electrospinning solution to achieve three distinct benefits, i.e., (i) facile synthesis of a WO3 nanotube by utilizing the self-agglomerating nature of CNC in the core of as-spun nanofibers, (ii) effective sensitization by partial phase transition from WO3 to Na2W4O13 induced by interaction between sodium-doped CNC and WO3 during calcination, and (iii) uniform functionalization with monodispersive apoferritin-derived Pt catalytic nanoparticles (2.22 ± 0.42 nm). Interestingly, the sensitization effect of Na2W4O13 on WO3 resulted in highly selective H2S sensing characteristics against seven different interfering molecules. Furthermore, synergistic effects with a bioinspired Pt catalyst induced a remarkably enhanced H2S response ( Rair/ Rgas = 203.5), unparalleled selectivity ( Rair/ Rgas < 1.3 for the interfering molecules), and rapid response (<10 s)/recovery (<30 s) time at 1 ppm of H2S under 95% relative humidity level. This work paves the way for a new class of cosensitization routes to overcome critical shortcomings of SMO-based chemical sensors, thus providing a potential platform for diagnosis of halitosis.
Extracted statement — Method of nanomaterial synthesis: Electrospinning
Research field: Nanoscience and Nanotechnology
Title: ZnO/Cu Nanocomposite: A Platform for Direct Electrochemistry of Enzymes and Biosensing Applications
Abstract: Unique structured nanomaterials can facilitate the direct electron transfer between redox proteins and the electrodes. Here, in situ directed growth on an electrode of a ZnO/Cu nanocomposite was prepared by a simple corrosion approach, which enables robust mechanical adhesion and electrical contact between the nanostructured ZnO and the electrodes. This is great help to realize the direct electron transfer between the electrode surface and the redox protein. SEM images demonstrate that the morphology of the ZnO/Cu nanocomposite has a large specific surface area, which is favorable to immobilize the biomolecules and construct biosensors. Using glucose oxidase (GOx) as a model, this ZnO/Cu nanocomposite is employed for immobilization of GOx and the construction of the glucose biosensor. Direct electron transfer of GOx is achieved at ZnO/Cu nanocomposite with a high heterogeneous electron transfer rate constant of 0.67 ± 0.06 s(-1). Such ZnO/Cu nanocomposite provides a good matrix for direct electrochemistry of enzymes and mediator-free enzymatic biosensors.
Extracted statement — Type of Biosensor: Enzymes
Research field: Nanoscience and Nanotechnology
Title: Enzymatic glucose biosensor based on ZnO nanorod array grown by hydrothermal decomposition
Abstract: We report herein a glucose biosensor based on glucose oxidase (GOx) immobilized on ZnO nanorod array grown by hydrothermal decomposition. In a phosphate buffer solution with a pH value of 7.4, negatively charged GOx was immobilized on positively charged ZnO nanorods through electrostatic interaction. At an applied potential of +0.8V versus Ag∕AgCl reference electrode, ZnO nanorods based biosensor presented a high and reproducible sensitivity of 23.1μAcm−2mM−1 with a response time of less than 5s. The biosensor shows a linear range from 0.01to3.45mM and an experiment limit of detection of 0.01mM. An apparent Michaelis-Menten constant of 2.9mM shows a high affinity between glucose and GOx immobilized on ZnO nanorods.
Extracted statement — Type of Biosensor: Glucose
Research field: Nanoscience and Nanotechnology
Title: Zinc oxide nanocomb biosensor for glucose detection
Abstract: Single crystal zinc oxide nanocombs were synthesized in bulk quantity by vapor phase transport. A glucose biosensor was constructed using these nanocombs as supporting materials for glucose oxidase (GOx) loading. The zinc oxide nanocomb glucose biosensor showed a high sensitivity (15.33μA∕cm2mM) for glucose detection and high affinity of GOx to glucose (the apparent Michaelis-Menten constant KMapp=2.19mM). The detection limit measured was 0.02mM. These results demonstrate that zinc oxide nanostructures have potential applications in biosensors.
Extracted statement — Type of Biosensor: Glucose
Research field: Nanoscience and Nanotechnology
Title: ZnO Nanotube Arrays as Biosensors for Glucose
Abstract: Highly oriented single-crystal ZnO nanotube (ZNT) arrays were prepared by a two-step electrochemical/chemical process on indium-doped tin oxide (ITO) coated glass in an aqueous solution. The prepared ZNT arrays were further used as a working electrode to fabricate an enzyme-based glucose biosensor through immobilizing glucose oxidase in conjunction with a Nafion coating. The present ZNT arrays-based biosensor exhibits high sensitivity of 30.85 μA cm−2 mM−1 at an applied potential of +0.8 V vs. SCE, wide linear calibration ranges from 10 μM to 4.2 mM, and a low limit of detection (LOD) at 10 μM (measured) for sensing of glucose. The apparent Michaelis−Menten constant KMapp was calculated to be 2.59 mM, indicating a higher bioactivity for the biosensor.
Extracted statement — Type of Biosensor: Glucose
Research field: Nanoscience and Nanotechnology
Title: A novel amperometric biosensor based on ZnO nanoparticles-modified carbon paste electrode for determination of glucose in human serum
Abstract: Abstract Zinc oxide nanoparticles-(ZnONPs)modified carbon paste enzyme electrodes (ZnONPsMCPE) were developed for determination of glucose. The determination of glucose was carried out by oxidation of H2O2 at +0.4 V. ZnONPsMCPE provided biocompatible microenvironment for GOx and necessary pathway of electron transfer between GOx and electrode. The response of GOx/ZnONPsMCPE was proportional to glucose concentration and detection limit was 9.1 × 10–3 mM. Km and Imax, were calculated as 0.124 mM and 2.033 μA. The developed biosensor exhibits high analytical performance with wide linear range (9.1 × 10–3–14.5 mM), selectivity and reproducibility. Serum glucose results allow us to ascertain practical utility of GOx/ZnONPsMCPE biosensor.
Extracted statement — Type of Biosensor: Glucose
Research field: Nanoscience and Nanotechnology
Title: Electrically conductive thermoplastic elastomer nanocomposites at ultralow graphene loading levels for strain sensor applications
Abstract: An electrically conductive ultralow percolation threshold of 0.1 wt% graphene was observed in the thermoplastic polyurethane (TPU) nanocomposites. The homogeneously dispersed graphene effectively enhanced the mechanical properties of TPU significantly at a low graphene loading of 0.2 wt%. These nanocomposites were subjected to cyclic loading to investigate the influences of graphene loading, strain amplitude and strain rate on the strain sensing performances. The two dimensional graphene and the flexible TPU matrix were found to endow these nanocomposites with a wide range of strain sensitivity (gauge factor ranging from 0.78 for TPU with 0.6 wt% graphene at the strain rate of 0.1 min−1 to 17.7 for TPU with 0.2 wt% graphene at the strain rate of 0.3 min−1) and good sensing stability for different strain patterns. In addition, these nanocomposites demonstrated good recoverability and reproducibility after stabilization by cyclic loading. An analytical model based on tunneling theory was used to simulate the resistance response to strain under different strain rates. The change in the number of conductive pathways and tunneling distance under strain was responsible for the observed resistance-strain behaviors. This study provides guidelines for the fabrication of graphene based polymer strain sensors.
Extracted statement — keywords: Graphene
Research field: Nanoscience and Nanotechnology
Title: A highly stretchable and sensitive strain sensor based on graphene–elastomer composites with a novel double-interconnected network
Abstract: The construction of a continuous conductive network with a low percolation threshold plays a key role in fabricating a high performance strain sensor. Herein, a highly stretchable and sensitive strain sensor based on binary rubber blend/graphene was fabricated by a simple and effective assembly approach. A novel double-interconnected network composed of compactly continuous graphene conductive networks was designed and constructed using the composites, thereby resulting in an ultralow percolation threshold of 0.3 vol%, approximately 12-fold lower than that of the conventional graphene-based composites with a homogeneously dispersed morphology (4.0 vol%). Near the percolation threshold, the sensors could be stretched in excess of 100% applied strain, and exhibited a high stretchability, sensitivity (gauge factor ∼82.5) and good reproducibility (∼300 cycles) of up to 100% strain under cyclic tensile tests. The proposed strategy provides a novel effective approach for constructing a double-interconnected conductive network using polymer composites, and is very competitive for developing and designing high performance strain sensors.
Extracted statement — keywords: Graphene
Research field: Nanoscience and Nanotechnology
Title: Fabrication of a SnO2 Nanowire Gas Sensor and Sensor Performance for Hydrogen
Abstract: SnO2 nanowire gas sensors have been fabricated on Cd−Au comb-shaped interdigitating electrodes using thermal evaporation of the mixed powders of SnO2 and active carbon. The self-assembly grown sensors have excellent performance in sensor response to hydrogen concentration in the range of 10 to 1000 ppm. This high response is attributed to the large portion of undercoordinated atoms on the surface of the SnO2 nanowires. The influence of the Debye length of the nanowires and the gap between electrodes in the gas sensor response is examined and discussed.
Extracted statement — keywords: Hydrogen
Research field: Nanoscience and Nanotechnology
Title: Ni and NiO Nanoparticles Decorated Metal–Organic Framework Nanosheets: Facile Synthesis and High-Performance Nonenzymatic Glucose Detection in Human Serum
Abstract: Ni-MOF (metal-organic framework)/Ni/NiO/carbon frame nanocomposite was formed by combing Ni and NiO nanoparticles and a C frame with Ni-MOF using an efficient one-step calcination method. The morphology and structure of Ni-MOF/Ni/NiO/C nanocomposite were characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and energy disperse spectroscopy (EDS) mapping. Ni-MOF/Ni/NiO/C nanocomposites were immobilized onto glassy carbon electrodes (GCEs) with Nafion film to construct high-performance nonenzymatic glucose and H2O2 electrochemical sensors. Cyclic voltammetric (CV) study showed Ni-MOF/Ni/NiO/C nanocomposite displayed better electrocatalytic activity toward glucose oxidation as compared to Ni-MOF. Amperometric study indicated the glucose sensor displayed high performance, offering a low detection limit (0.8 μM), a high sensitivity of 367.45 mA M-1 cm-2, and a wide linear range (from 4 to 5664 μM). Importantly, good reproducibility, long-time stability, and excellent selectivity were obtained within the as-fabricated glucose sensor. Furthermore, the constructed high-performance sensor was utilized to monitor the glucose levels in human serum, and satisfactory results were obtained. It demonstrated the Ni-MOF/Ni/NiO/C nanocomposite can be used as a good electrochemical sensing material in practical biological applications.
Extracted statement — keywords: Metal-organic
Research field: Nanoscience and Nanotechnology
Title: A Highly Sensitive and Flexible Capacitive Pressure Sensor Based on a Porous Three-Dimensional PDMS/Microsphere Composite
Abstract: <jats:p>In recent times, polymer-based flexible pressure sensors have been attracting a lot of attention because of their various applications. A highly sensitive and flexible sensor is suggested, capable of being attached to the human body, based on a three-dimensional dielectric elastomeric structure of polydimethylsiloxane (PDMS) and microsphere composite. This sensor has maximal porosity due to macropores created by sacrificial layer grains and micropores generated by microspheres pre-mixed with PDMS, allowing it to operate at a wider pressure range (~150 kPa) while maintaining a sensitivity (of 0.124 kPa−1 in a range of 0~15 kPa) better than in previous studies. The maximized pores can cause deformation in the structure, allowing for the detection of small changes in pressure. In addition to exhibiting a fast rise time (~167 ms) and fall time (~117 ms), as well as excellent reproducibility, the fabricated pressure sensor exhibits reliability in its response to repeated mechanical stimuli (2.5 kPa, 1000 cycles). As an application, we develop a wearable device for monitoring repeated tiny motions, such as the pulse on the human neck and swallowing at the Adam’s apple. This sensory device is also used to detect movements in the index finger and to monitor an insole system in real-time.</jats:p>
Extracted statement — keywords: Microspheres
Research field: Nanoscience and Nanotechnology
Title: Electrically conductive thermoplastic elastomer nanocomposites at ultralow graphene loading levels for strain sensor applications
Abstract: An electrically conductive ultralow percolation threshold of 0.1 wt% graphene was observed in the thermoplastic polyurethane (TPU) nanocomposites. The homogeneously dispersed graphene effectively enhanced the mechanical properties of TPU significantly at a low graphene loading of 0.2 wt%. These nanocomposites were subjected to cyclic loading to investigate the influences of graphene loading, strain amplitude and strain rate on the strain sensing performances. The two dimensional graphene and the flexible TPU matrix were found to endow these nanocomposites with a wide range of strain sensitivity (gauge factor ranging from 0.78 for TPU with 0.6 wt% graphene at the strain rate of 0.1 min−1 to 17.7 for TPU with 0.2 wt% graphene at the strain rate of 0.3 min−1) and good sensing stability for different strain patterns. In addition, these nanocomposites demonstrated good recoverability and reproducibility after stabilization by cyclic loading. An analytical model based on tunneling theory was used to simulate the resistance response to strain under different strain rates. The change in the number of conductive pathways and tunneling distance under strain was responsible for the observed resistance-strain behaviors. This study provides guidelines for the fabrication of graphene based polymer strain sensors.
Extracted statement — keywords: Nanocomposites
Research field: Nanoscience and Nanotechnology
Title: Fabrication of a SnO2 Nanowire Gas Sensor and Sensor Performance for Hydrogen
Abstract: SnO2 nanowire gas sensors have been fabricated on Cd−Au comb-shaped interdigitating electrodes using thermal evaporation of the mixed powders of SnO2 and active carbon. The self-assembly grown sensors have excellent performance in sensor response to hydrogen concentration in the range of 10 to 1000 ppm. This high response is attributed to the large portion of undercoordinated atoms on the surface of the SnO2 nanowires. The influence of the Debye length of the nanowires and the gap between electrodes in the gas sensor response is examined and discussed.
Extracted statement — keywords: Nanowires
Research field: Nanoscience and Nanotechnology
Title: Fabrication of a SnO2 Nanowire Gas Sensor and Sensor Performance for Hydrogen
Abstract: SnO2 nanowire gas sensors have been fabricated on Cd−Au comb-shaped interdigitating electrodes using thermal evaporation of the mixed powders of SnO2 and active carbon. The self-assembly grown sensors have excellent performance in sensor response to hydrogen concentration in the range of 10 to 1000 ppm. This high response is attributed to the large portion of undercoordinated atoms on the surface of the SnO2 nanowires. The influence of the Debye length of the nanowires and the gap between electrodes in the gas sensor response is examined and discussed.
Extracted statement — keywords: Sensors
Research field: Nanoscience and Nanotechnology
Title: Structure and optical properties of TiO2 thin films deposited by ALD method
Abstract: <jats:title>Abstract</jats:title><jats:p>This paper presents the results of study on titanium dioxide thin films prepared by atomic layer deposition method on a silicon substrate. The changes of surface morphology have been observed in topographic images performed with the atomic force microscope (AFM) and scanning electron microscope (SEM). Obtained roughness parameters have been calculated with XEI Park Systems software. Qualitative studies of chemical composition were also performed using the energy dispersive spectrometer (EDS). The structure of titanium dioxide was investigated by X-ray crystallography. A variety of crystalline TiO<jats:sub>2</jats:sub>was also confirmed by using the Raman spectrometer. The optical reflection spectra have been measured with UV-Vis spectrophotometry.</jats:p>
Extracted statement — substrate: Silicon