Maiduguri tana da manyan titunan mota kamar su Sir Kashim Ibrahim Road, Shehu Laminu Way, Bama Road, Jos Road da Baga Road. Hanyoyin motan sun hada Maidguri da sauran Birane kamar Yola, Kano da Bauchi. Akwai kuma hanyoyi zuwa kasashen waje kamar Chadi, Nijar da Kamaru.