Yawancin mutanen garin Maiduguri dai manoma ne amma akwai 'yan kasuwa da dama da kuma ma aikatan gwamnati. Manyan masana'antun Maiduguri sun hada da Maiduguri Flour Mills, kamfin sarrafa Dalaram (wanda a halin yanzu ta dur'kushe), kamfanin Coca Cola, Borno Aluminium company, Kamfin Alewa ta Haske da kuma kamfanin sarrafa takalma ta Natel. Akwai bankuna da yawa a Maiduguri a kan titin Shehu Laminu Way. Yawancin bakuna suna da daukan ku'di da kanka wato ATM.