The initial dounset on the shore o the Paraná wis cried Puerto de Piedras. The toun wis foondit bi the initiative o some businessmen frae nearbi Rosario, efter receivin authorization frae the govrenment o Santa Fe. The aurie wis strategically important acause it wis adequate for a port an next tae the Arroyo del Medio, which is the natural border wi the Buenos Aires Province. The residents o Puerto de Piedras attendit the foondation o the new toun, wi the presence o govrenor Juan Pablo López, on 14 Februar 1858. The name Villa Constitución wis gien tae the toun to honor the Assembly that haed promulgatit the Constitution o 1852.