The toun stairtit tae grow substantially wi the arrival o the railwey in 1888–1890 (the station at the junction o the line comin frae the port wi the Buenos Aires–Rosario railwey gae rise tae the toun o Empalme Villa Constitución). Villa Constitución became an important agricultural center, an then (syne the mid-20t hunderyear) hame for mony industrial enterprises.