Oyena nobangela uqhelekileyo lusuleleko lwamathumbungenxa nokuba yintsholongwane, ibacteria, inkcukuthu, okanye imeko eyaziwa i-gastroenteritis. Olu suleleleko ludla ngokufumaneka ekutyeni okanye amanzi asulelekilwe lilindle, okanye ngqo ukusuka komnye umntu owasulelekileyo. IKungohlulwa kube ziindidi ezintathu: ubude bexesha elifutshane besisu esihambisa amanzi, ubude bexesha elifutshane besisu segazi, kwaye ukuba siqhuba kude kube ziiveki ezingaphezu kwezimbini, isisu esihambisa oko. Ubude bexesha elifutshane besisu esihambisa amanzi kungenzeka ngenxa yolwasuleleko yi-cholera. Ukuba kukho negazi oko kwaziwa njenge dysentery. Inani lokungosuleleki lingakhokelele kwisisu eshambisayo kuquka: i-hyperthyroidism, ukungavumelani neswekile yobisi, isifo sokukrala kwamathumbu, inani lamayeza, kunye nesindrom yokutyabuka kwamathumbu phakathi kwezinye. Kwizehlo ezininzi iintsholongwange zelindle aziyomfuneko ukuqinisekisa oyena nobangela.