Lino ddagala erikozesebwa mu kujjanjaba akawuka ka HIV. Empeke za NNRTIs ziziiza (inhibit) ekirungo Reverse transcriptase (RT) ekiyamba akawuka okwekubisaamu oba okweyaluza (replication). Abanoonyereza ku ddagala ly’akawuka ekirungo kya RT kye kimu ku bye batunuulidde okugaziyirizaako.