Isakhiwo esikhulu seZizwe eziManyeneyo sikwisixeko saseNewYork kwiZizwe zaseMelika eziManyeneyo, kodwa zona iZizwe eziManyeneyo nazo zinee-ofisi zazo ezibalulekileyo eGeneva (e-Switzerland), e-Nairobi (e-Kenya) nase-Vienna (e-Austria). Izizwe ezimanyeneyo zizama ukubanoxolo, kodwa ngamanye amaxesha xa ukuthetha kungasasebenzi, amazwe amanyeneyo, akafani namazwe namazwe obuhlobo, ayalwa nawo. ngeminyaka yoo-1950 amazwe amanyeneyo aanceda kwmfazwe eyayiphakathi kwamaKorea aseMzantsi namaKorea asemantla, kwaza ngeminyaka yoo-1990 amazwe amanyeneyo ancedisa ukunyanzela amajoni ase-Iraqi ukuba aphume e-Kuwait. Ngamanye amaxesha, iZizwe eziManyeneyo yakhe imikhozi 'yokugcina uxolo'. Abagcini xolo beZizwe eziManyeneyo bakhenketha kwiindawo ngeendawo ezineenkathazo ehlabathini bezama - ngamanye amaxesha bakwenze ngempumelelo oko, ngamanye a bangasebenzeli kugcina xolo. Namhlanje kukho abagcini-xolo bamazwe amanyeneyo abasebenza eAfghanistan, eCyprus, eHaiti, ei-Liberia nakwamanye amazwe aliqela. Ngenxa yothotho lweenjongo, olwezisombululo, kunye nemimiselo ethe yaphakanyiswa zizizwe ezingamalungu amazwe amanyeneyo, ihlabathi linengqokolela yemigqaliselo, amanyathelo, kunye nempumelelo ukuze kuphele kuncitshiswe namathuba okunwenwa kwentsholongwane ye-H.I.V. kuze kubheke phezulu ukufikelela kwehlabathi kwizinga lokukhusela, ukunyanga, ukunonophela, kunye neenkonzo zenkxaso.